<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="https://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVH5</accession>
    <name>A0A317UVH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461573.1">
        <property type="nucleotide sequence ID" value="XM_025612983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVH5"/>
    <dbReference type="GeneID" id="37115126"/>
    <dbReference type="OrthoDB" id="5366485at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056539">
        <property type="entry name" value="NuiA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42093:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23151">
        <property type="entry name" value="NuiA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="266" mass="28932" checksum="D4A5D458CA65F7A6" modified="2018-10-10" version="1">MSAACLRRWPLSRPGHCVIDPIVPWASTSFSSSTFSTTHLSAAQLPLRIIQTHYSSHYHHLCPSQRRLPNKPSVLSSTTRPTTHITPPCPTLTTLTTRTMSSDDAYMSFLDKANADLSAGQSQPATTTSSSARTETIHTDVRIPTPLTSVNAFYISETDEPFEPVALKWDGAARGIWPDASHLSKLISPDKDLSAEIETLSPAMFDPRNHYAGVLKAVRASAGDEQGADIKVYRVEVGSSRVEYFVLGLDVAQGLLVGLRAKAIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZC7</accession>
    <name>A0A317UZC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_479219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461857.1">
        <property type="nucleotide sequence ID" value="XM_025608737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZC7"/>
    <dbReference type="GeneID" id="37110880"/>
    <dbReference type="OrthoDB" id="4482998at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016445723" evidence="1">
        <location>
            <begin position="17"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="80" mass="9062" checksum="9653977025B4A0FE" modified="2018-10-10" version="1">MKLSLIAVTLLGLAMATPAEQNTNDVGSTKATDGTLGVDYCGERCQYDWECRRGDRCHDCYRRSGERYGHCRRRRSDDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZL7</accession>
    <name>A0A317UZL7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_551405</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000050">
        <property type="protein sequence ID" value="PWY66809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461745.1">
        <property type="nucleotide sequence ID" value="XM_025613543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZL7"/>
    <dbReference type="STRING" id="1450535.A0A317UZL7"/>
    <dbReference type="GeneID" id="37115686"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07102">
        <property type="entry name" value="ALDH_EDX86601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY66809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="466" mass="50917" checksum="223B1D86FF4404E4" modified="2018-10-10" version="1">MSNKICTLSPSTNKVIFEHPGISLDEARQIAQASQDAFRTYKQTTLAQRKEIILKALDLIAANKETLAEELTTQMGRPIAFSAKEIETFRKRGDYLLDIAEDSLKSLPGAPENGFRRFLKKEPVGPTLIITAWNFPYLVTINALVPALLAGNTVLLRPSPQTPIFGERLLQYFTEAGLPPNVLQLVHCGSPEVLDQIVQLPQIQLISFTGSTAGGFRIREATARRIVPVNLELGGNDPAYVRPDADIPYVAAQLVDGAVFNSGQSCCAVERVYVHADVHDAFVEEVKKELATYKLGSPHDKSTTTGPVVSQAALKNIQSHITDAVSKGAINATPENASFVNPPAEGNYQPPTVLTNVTHEMVVMKEETFGPVMPIMKVSSDEEAITLMNDSDYGLTASIWTKDIKKGEELIDSLEAGTVYINRCDYPSPDLAWIGWKNSGLGCTLGPQGFDAFYKLKSFHIKEAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0Y9</accession>
    <name>A0A317V0Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hscarg dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_305553</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY67994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462043.1">
        <property type="nucleotide sequence ID" value="XM_025606780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0Y9"/>
    <dbReference type="STRING" id="1450535.A0A317V0Y9"/>
    <dbReference type="GeneID" id="37108923"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF11">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY67994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="310" mass="33796" checksum="AC87262710BED9E3" modified="2018-10-10" version="1">MSKILVVVGATGQQGGSIVDTVLADPELGQEYTIRGTTRDPSSSSAKALAAKGVEIVSADFSDPESLQRAFTGAHVVFGNTTTIYDGHTYEHEVNHGRALVDAAVAVGVPFYIYSSLPNISKNSNRALKWGGHFDGKEEVEQYIRSLPIRSAFIAPGSFMSNFHQTMTPRAMGDGTYALASFVTPETQLPLINTAGDTGKWVAAILADFAKYEGKVLCCATALYSFTEIAETMSRVSGKTVVYRQLPEEIWRGFLPPLMVDYIADMLKSFQDYGYYGEGTEEKVRWSAEQARGELTTLEGYLQAHSLSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V358</accession>
    <name>A0A317V358_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pali-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_540203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462188.1">
        <property type="nucleotide sequence ID" value="XM_025612862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V358"/>
    <dbReference type="STRING" id="1450535.A0A317V358"/>
    <dbReference type="GeneID" id="37115005"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="557"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="606"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY68525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="640" mass="67876" checksum="4759E30F90FB9CC8" modified="2018-10-10" version="1">MLLKPATPLTILLLIAFALLLISVISTPIVKSIALARHDNVDYGVFGYCKGDVCTSIHVGYADDDITSEDGTFSIAPSTRRSLSAILIVHPVAAFLTLICLCLAAAAHFHAPSHSPRYLLALLILLLPTLLVSLLAFLVDILLFVPHMAWAGWIVLVATILLVTCGVVTCAMRRTLVSRKARKKRINENAEMSGENYYNRQNAAAAAAGLNDPAPLSMDTKEPVVTGSPPSSETGPTFATFRTTTHDSDDDRTPLNSRNPQTEPPLPDNQYARVRADRMAYNSSPEEAGIPAGTHAPGPRMHPGQPDPRLRNQYSDGSMGSRRGPPPPGFARGRGGYPARGGYGRGAPYGGPGPRGPPPGMNGGPMGPMRGGHLGPMGRGYRGPPPGGYAPAPRPTPPPEDEYEYRHPSPVATRQPSPGPIGMAVSPDHASPIEQAIEMQPQPRRVGSADPEAHDVILQAQPHALSIDGYQEPISPSSLYSGSYAPARAGWAPEAPHVGHSPSPVHAYGGAPQHARTPSADYFEDADPRFATNESAVGKARLPAVLTPGAIGERKPMVDLAEGPSSPTTSEVSHFTSISERPINPRWRPPPMPAQRAQDVLLENNPDFDLRAGTGRGGAGGVGSRMPAVSIPRDAARYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7M1</accession>
    <name>A0A317V7M1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_304636</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462142.1">
        <property type="nucleotide sequence ID" value="XM_025606771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7M1"/>
    <dbReference type="STRING" id="1450535.A0A317V7M1"/>
    <dbReference type="GeneID" id="37108914"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="278"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY68120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="55020" checksum="3F9ED2F1FEAD13C2" modified="2018-10-10" version="1">MEFKTLEDGTTVESKQATASVEEQSLVKPQGLFARIRYYEELLDRKLGVESHSLDRVLPENRQPPNTLAMAFIWASATMNLSCFSTGFMGKEFGLSLGQTIPIMICATFLGACLTGWCATMGPGTGLRQVAISRYSFGFYPSSIIAALNVIEQLGWASVSCITGGQALRAVSDGHISMIVGVVIVACVSLCFSFFGLKAVMTIEQFIWMIAFVVFIIIYGESAHHANLSDPPTVSGMTRSGNVLSLISVIYGSSASWCSIVSDFYVHYPVNTSKVKVFIYTTLGISLPTCIGMLLGACIASALDENPEWAAAYDEGIGEILQTIIYPRGFSKFLLVLLVLCGIGMNCIAIYAGALSAQLFAKPFQKIPRIVWTLIVFACILVIGIAGRDHLLAVLDNFLSLLGYWNTSFFVILFTEHYFFRNGNLANYDLDAWNTPSKLPAGYAGLTAFLCGAAGWIVGMDETYYVGALARKIGTDGGDIANELALVFTSVSYIPLRMLELKYIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V817</accession>
    <name>A0A317V817_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TLC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_569769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462277.1">
        <property type="nucleotide sequence ID" value="XM_025614754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V817"/>
    <dbReference type="STRING" id="1450535.A0A317V817"/>
    <dbReference type="GeneID" id="37116897"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="156"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY68962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="451" mass="51165" checksum="881B73A0E2256D93" modified="2018-10-10" version="1">MSDSKSNVEDVGETAQEPSIPSTSPAHNESRTKPPPYSQGTTDRTTTEASVSPMNTGVLKWYARGVVDNQIGIFLHLVSVLVLTHLYVPTARPFTSRLLLLSHYNPDTQLYGISTDDFYLVGFYVFFLSGLRVFLMEHVLAPVGRQLGLSNGRDLKRFSEQGWLLSYFFVSWILGMYIYCTSECFLNMRQMFTDWPTRELPAITKAYILGQWAFWQQQVIAIHLEERRRDHWQMLAHHVIANALIFTSYVLHLTRVANLILVLMDVVDIVFCLAKCLKYLGYSTLCNITFGVFMITWFVARHVFYLMTMWSIWIDMAEVIPVGCYHGSQRDLKGPTPLPQHGWMHILDPFLNPAGTICFSRAIQGWFLGSLGFLQILTMVWFIMIIKVAIRVVKGDGATDIRSVHESENEEEQEEEGWVTAVVEEGVDEIVGGGGSYRGWRGGERAGHGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V849</accession>
    <name>A0A317V849_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Yippee family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_540022</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462372.1">
        <property type="nucleotide sequence ID" value="XM_025612825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V849"/>
    <dbReference type="STRING" id="1450535.A0A317V849"/>
    <dbReference type="GeneID" id="37114968"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="4">
        <location>
            <begin position="47"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY69167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="235" mass="25745" checksum="B3BE653302CB577D" modified="2018-10-10" version="1">MFAEFLLRPTVFRNMQPNMGTRASFSEIVSGSSLESHDTNYLNGHISRIRCSCCAADICLTSQIISKGFTGRHGRAFLVSGEPIISALAMKSSPTDSLPNTIIQKPVPRRLVTGAHTVGDISCALCGNVLGWKYVAAEEGSQRYKVGKFILETERIMTSSSWESPSYVDPAMLSVPLGSGESVFETSENGTEFDSQNEDECEDLFAGIWSPGLAKRRRNRKLPGRRPSLFGIKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBK0</accession>
    <name>A0A317VBK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cystathionine beta-synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_539847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462669.1">
        <property type="nucleotide sequence ID" value="XM_025612790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBK0"/>
    <dbReference type="GeneID" id="37114933"/>
    <dbReference type="OrthoDB" id="2536440at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY70378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19796" checksum="40927350A735CAE0" modified="2018-10-10" version="1">MASYMNASEALTQQQLAQNAEQPAAQSSWANKYRGATVEDLDPNPALSVSPHDPISTAMIAAYERDYTHLTVTSSTKRSLVGYLSIPRLKQLLKEGAVKESDPVSAAMQRFNRKRGTYQVITMETPLEELEQFFESETGPNGEPRAKQEFAVVTDVSRKFVLGVATKADLGEFVKRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VD58</accession>
    <name>A0A317VD58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_266701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462716.1">
        <property type="nucleotide sequence ID" value="XM_025606528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VD58"/>
    <dbReference type="STRING" id="1450535.A0A317VD58"/>
    <dbReference type="GeneID" id="37108671"/>
    <dbReference type="OrthoDB" id="4435015at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="181" mass="19974" checksum="C68B04B0C7105748" modified="2018-10-10" version="1">MSTEPLLPSYASATQHRYQSFRRRSAIVIPAVPPDPAVPVIQTLSALTFTGTTIVSTAWAYRSYAPPDLSPPVSAPLLPYFASLCLTISLSFWVGYLIFILYDEAGGPTMQRKIVVGVSAVGKLVLAGAHIGVWLGYKYLGLGPRQPNWGLMFLAAQAWWDLLLFVVYSCLRAKEEPRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VEJ2</accession>
    <name>A0A317VEJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter OPT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_268919</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462591.1">
        <property type="nucleotide sequence ID" value="XM_025606541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VEJ2"/>
    <dbReference type="GeneID" id="37108684"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="696"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="720"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY70300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="776" mass="89215" checksum="2CBFA7B35A75DAC2" modified="2018-10-10" version="1">MADEVTDSPPSTPVEVNEKKPDLHVQEKADIQDVEVAPGFVAEADFEGHYKDVPIGEGIVPDDNDEFIDPRLKDYPIPLVAKTVDLRNDPTEPILTFRFWTLSTFWVLVGCALSTFYYFKPYYNTITSYAVQLLSWGMGDAMAKYLPKRQFSFFGWKWTMNPGPWNAKEHALIVVAYWGSCYTAYGMGPLSAIELYYGEKLNAGWSMFFLLASQMIGYGFAGLFRDILVRPPQMYYPGVLPNVSLFNAMHKNPSVTKKALKYFAIVASVTFVYEWLPELIFPLLSSLPLICWFGHGNWKAFVLGSGTYGFGILDLSLDWNYITFLSPYYTPLWSSLNQGIFAMFCCWVLYPLIYFTNTMNAQNFAPMDTGTYTANGSTYDVTAIVGSNMELNRTALAEYGAPYWAPSYVFYWFWTFAALTASMAYAILWYGKSGWRDLKAAWQNKRSDYDDPYLKMMSFQKRVPHWWYLTLLVICAVIAIAQGYEGNMKLSWWGFVVICLFSFVFTWPNGILWAVANIQVGMGSFSDLLAGAMFPGKPTAVLSAYTYGYCVLEQNLNLISDYKFGFYMKIPEREMFWGQVWGTVLGPFINYGFMQLIIDRERPFLIGQRSSEAWDAVQTRVYYSNSIIWGILGPKEFFVDRYPWVYYSFVVGAGTVIVTWLVQKWKPKWDLERWFNPTLLFYGGYLFPYYPTTNFFMSFLACILFMGILPRYFPVWWRKYNYLTGVGLDCGTQLMTLVCIFVVNLPNLSFPAWWGNYPDVTDRCFPPSDLPANALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VF30</accession>
    <name>A0A317VF30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">mRNA cleavage and polyadenylation specificity factor complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_501006</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463269.1">
        <property type="nucleotide sequence ID" value="XM_025609421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VF30"/>
    <dbReference type="STRING" id="1450535.A0A317VF30"/>
    <dbReference type="GeneID" id="37111564"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="5">
        <location>
            <begin position="90"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="706"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY72495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="761" mass="84653" checksum="804069CFD1BB2040" modified="2018-10-10" version="1" fragment="single">MAQSTDLVDQIAQLNAARNLVLGDAAFYPQIVNGVLPLIGAHTRLELRQWGAEFLAETFASPALALSQKEQLAPKVLQTLREILELPEGDPLVLKHIVQNAASLYPLVFRHIINHPADATAWENMTAIKEDILRRWDSFPFPVKICCIKFVQRVVHVQTHGSIADPRRPEQNETSLAIVPRNHALLSLPNLEAEASGLLDRLLSVFQEDSSDPLLVNATLNCLAVLIRTRQSVGNKIINAIMNFFPARQVRPPITPSVRVGVKSMERTARAVLINIIKRNSSHPLVGKMQQYIERLMQSRIEMIDEASRKRGLPSEPTDGLDNIKRAKLDAETPALVKIPPLPPGPTSYAQLFTITEDKELRGFDVKQLPVDMLVKMVVPILARVDQSMMSQSIEGIRMRYQAIQKQQAAQLPAATAEAEDDDDYEPEYQPMDVAEPAAEQAEAVAAEVADLQPDLVSLGPFVLPQPPPLAEDEAADIGRSAVGRVFGMLASTGVAPNPAKGKSQQQPGFARLAGSTFDRDAWVTLLTRLATRAPAGLEAGGKSEKGKPTISDSIRETLYRYILEDFRGRVNVGIMWLNEEWYNDRIQMEFTAQQRSDEDDEATVPLHYDHWVLRLLDGFLPYLDSRDTKIFIRFLSEIPEVTIPITKRVASLAKDPERVNLCVQSLLYLIMFRPPAREMCLNALEDVYQAYEESRPAAGKILARWRPPKTEEQLPQDQPQPQDQQQPRLIASETNTPVPNGTEESVPTPPQPADATPAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VF81</accession>
    <name>A0A317VF81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_248510</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463072.1">
        <property type="nucleotide sequence ID" value="XM_025606424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VF81"/>
    <dbReference type="STRING" id="1450535.A0A317VF81"/>
    <dbReference type="GeneID" id="37108567"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY72119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="217" mass="24138" checksum="43674F3E6197C1A8" modified="2018-10-10" version="1" fragment="single">MASEDNILQTNALAVREYIHSQPQDALLNNPWAVYQALDLYSRTARLMNFKRAKLNIAQDALTTMETAPKIIIEFGTYIGCSAIAWAAILRDLHGPFAEGLHIYTFEVSETVAEVARDLIRVAGVEDIVHVLVGPASESLKQLVEEGKVKAKGVDMAFFDHWEKFYLSDLQLCEDLNLFREGSRVIADNTDIPGAPDYLEYVRAGGRGGEGSVRYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFQ2</accession>
    <name>A0A317VFQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ADP-ribosylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_589570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463478.1">
        <property type="nucleotide sequence ID" value="XM_025615954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFQ2"/>
    <dbReference type="STRING" id="1450535.A0A317VFQ2"/>
    <dbReference type="GeneID" id="37118097"/>
    <dbReference type="OrthoDB" id="5430812at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY73213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="594" mass="67641" checksum="ED99AFF948597DC5" modified="2018-10-10" version="1">MSELVRSLSFQGPQEYYSSFITRPHLQHAFRNIDEANNLKAYLALLKDAQTRSFVLDFGNDDAWCAVNLDQEDLALLLRKPKPRCFGTRWINIWAPEQQKELIKTITSHYGVSERLQGMMCTDPVERPSKSAAPAEPPRNNLRPRNTDRVRRSRPDDVEGNALRDLTNPEEIGAAASFRGLTFANVIDQIWHFCSVDYGPKYTCVGYNSLFVVPHLDMDNGKELPAGKRLWSWLILCDDGTVICMQENPFPGLSGPSEKVLQSVLNVVRRNMQLIFAGVSKQHFAASESDSLVTIRVRPFYEGGPDQVSIKQDDGPSLLFYYLFDDWVSSYALVAQREHKYGVSLNRLRQDMLSKPVVDLIHELHRLGRQLAVLKRLYQSYELIMMRILQRQRMLRDEARSNRPQWAIGQSFGENDGADAHHSTSRSSFSFPTIPDASVGVQLSPPAVARFERLLDRIKLYCLSEIDSCLTEKENLTFLNFNLIALKDSQAVEKLTRITILLAKVTILFLPVSLMTGYFSTELRNVKGEYTINQYWVSFGVIMFLSAVLLWIFGYASDTVEGKTIYQSLSRSFFRMSRDKVSHHRNEASGGASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFU7</accession>
    <name>A0A317VFU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_476191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463018.1">
        <property type="nucleotide sequence ID" value="XM_025608596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFU7"/>
    <dbReference type="STRING" id="1450535.A0A317VFU7"/>
    <dbReference type="GeneID" id="37110739"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF77">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY71782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="751" mass="84026" checksum="4D8FD41ED1BC6864" modified="2018-10-10" version="1">MPTKPRSHRSLRKHVTTACIPCRDGKVKCGGGTPTCRNCAIRGKTCRYRQGDDKRKVPVRQAVALLARRVDSLVHYIRGCELPVPTMGEEDHRILKNVLDALELQCEDVSYSEKSTSIEGNPKLPNSTIVPTTPISLNSGAHNSHPSEGESLGETAPNSVHPPEQSRPTWEDTVAQEIPGDGDWDSDDEVTDQLSCRLGRLQVTHDGQLRYFGSTSNLTLLDALVDVTPPVTIARDAPELLESAQLDHDIDEGFERHLLELFFTWQDPSLHIIDAESFWRARAQSQDESLATPYYSRALSDAMCALGAAYEPKYHPDFVTFPRSLAEYFGDRAKILVELELDTPSIATIQALVLLSTHEASCTRDTRGWLYSEGMAMRLTLDLGLHLEMAPYVEKGIIPHQDAEVRRMVFWGVYLNEQFWGFYLGRSAQSRMDIVTVQKPAARTLSLTCWKPYPAVGATLAHIPFSLLCREWLSLYEIMLPLTDVLYGCSEISVHVLQELAVVTVNKLGQWRIDLPEELTADEVSSLTTPLPHVLTLHMQYHQFMIHCHKPYISRRYIQPQPPQGPGSGHARKMCIDSAVAIVQLLLRYERAYGFEKSNIQMVSFVFSAALILIFNTVPTKPMSSDQQLVTHLSTCFRALDKMASCFENARRTSVFLGILRRQWQVRRRSRRAPGDPGREKGFSESSGWRRDDAAMSPTFDQGTVGGLGSGIDDLLWCYSALGDAHASTVDFMGPNLCNILLSEGIPRAFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGS6</accession>
    <name>A0A317VGS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">ABC multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_539013</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463400.1">
        <property type="nucleotide sequence ID" value="XM_025612610.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VGS6"/>
    <dbReference type="GeneID" id="37114753"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001601">
        <property type="entry name" value="ABC multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="755"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1180"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1211"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1255"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1293"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1328"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1446"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="147"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="841"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY73135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1483" mass="166224" checksum="5158C8826A2C24DB" modified="2018-10-10" version="1">MASDQRGLWPQDDDHLLRQSTPNTLVSQNEEDTATPSVDLIGPEERETLVRIATADSARRRSSVYTQHTATGKRDTLETIREDDPRLDPQTDKFDLGKWLAFRLREFQRDGSRTLRPGIVFKNLTITGTGAAVQFQDTVGSTLSAPFRIGDLLRNRHSPSKRILNEFNGLMKSGELLLVLGRPGAGCSTFLKSLCGQLDGLTVDENSVIHYNGIPQHQMIREFKGEVVYNQEVDKHFPHLTVGQTLEFAAAMRTPQHRIKDMSRDEYAQYLTKVVMAIFGLSHTYNTKVGNEFIRGVSGGERKRVSIAEMALAASPLAAWDNSTRGLDSATALKFVEALRLFADLTGSAHAIAIYQASQSIYDIFDKVTVFYEGRQIYFGPTSEAKTFFERQGWECPLRQTTGDFLTSVTNPQERQPRAGMEDRVPRTPDDFEAYWRKSPEYQKVLADIASYEKQYPLHEGKLTDTEFHERKRAAQANHTRSGSPFLLSIPMQVRLNTRRAYQRLWNDIQTAISNVSGQMIMALIIGSVYYNSPNDTASFTSKGAALFFAVLLNALGAMAEINLLYAQRPIVEKQASYAFYHPATEAIAGIVSDIPVKFALAVVFNIILYFLVNLRREPAQFFIYFLISFIIMFVMSAVFRTMAAITKTVSQAMTLGGVLILALVVYTGFMLPVPSMHPWLEWIHYINPIYYAFEILIANEFHGREFPCSSFIPSYADMDGSAFVCSASGSTAGSKFVSGDEYIALNFRYYYSHVWRNFGILIAFLIGFMAIYFFATEWNSSTTSTAEVLVFRRSQKRALDSNNPKPSDIENGVELGTVKPTATGERPENLTALAPQQDIFTWRDVSYDVDIKGETRRLLDHVSGWVRPGTLTALMGVSGAGKTTLLDVLAHRTSIGVITGDMFVNGRGLDASFQRKTGYVQQQDLHLETATVRESLQFSALLRQPATVSLKEKYDYVEEVISMLKMEDFAEAVVGVPGEGLNVEQRKLLTIGVELAAKPKLLLFLDEPTSGLDSQSSWAICAFLRRLADNGQAVLCTIHQPSAVLFQQFDRLLFLARGGKTVYFGPVGENSRTLLDYFETNGAPRTCGEAENPAEYMLEVINKGSNAHGQDWFDVWKQSNESQAVQAEIDRIHDQQQKKVPVENETEGSHAEFAMPFWFQLYQVTYRVFQQYWRLPSYVLAKWGLGVFGGLFIGFSFYHAKSSLQGLQTVIYSIFMLCSIFPSLVQQIMPLFITQRDLYEVRERPSKAYSWKAFVLANIIVEIPYQVILGIIVFACYYFPVVGIQGSAQQATVLILCIELFIYASTFAQMVIAAIPDTVTGSAVVTLLFAMSLTFCGIMQSPSALPGFWIFMYRASPFTYWASAMVSVQVHGRAVTCSDSEVSVLSPPSGQTCGQYLNQYAELTGGNLLNPNATADCKYCSVSTADEFITASGIEYNQHWRNFGIFWVYVVVQVAATAAIYYLFRVKNWKKDASKKKQETKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VI53</accession>
    <name>A0A317VI53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_539018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463404.1">
        <property type="nucleotide sequence ID" value="XM_025612612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VI53"/>
    <dbReference type="STRING" id="1450535.A0A317VI53"/>
    <dbReference type="GeneID" id="37114755"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="50"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY73139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="440" mass="48317" checksum="C35A440940F0E75D" modified="2018-10-10" version="1">MSGLARTANLLLRSSRASLLRPRGVNPIQHVFAKDKLAARGMATAFERTKPHVNIGTIGHVDHGKTTLTAAITKHQASKGLAQFLEYGAIDKAPEERKRGITISSAHIEYATDNRHYSHVDCPGHADYIKNMITGAANMDGAIIVVAASDGQMPQTREHLLLARQVGVQKIVVFVNKVDAIDDPEMLELVELEMRELLDTYGFEGEKTPIIFGSALCALEDRQADIGTQRIDSLLEAVDTWIPTPQRDLDKPFLMSIEEVFSIPGRGTVASGRVERGLLKKDSEVEIIGTSNEVIKTKVTDIETFKKSCDESRAGDNSGLLLRGVRREDLRRGMVIAAPGSAKANNKFMVSMYVLTEAEGGRRTGFGVQYRPQLFIRTADEAAEFSFPDEDQSRRIMPGDNVEVIVKTHRPVAAEAGQRFNIREGGRTVATGLVTRVLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJV2</accession>
    <name>A0A317VJV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_251939</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463133.1">
        <property type="nucleotide sequence ID" value="XM_025606436.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VJV2"/>
    <dbReference type="GeneID" id="37108579"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="354"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1312"/>
            <end position="1333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY72180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1369" mass="153057" checksum="7B0D79D77ED6CE5D" modified="2018-10-10" version="1">MLSRVALQKNAFARLRLAKGRSVLPSAASLRLHSNSSRPIALTNPSANITQERSRRPSFQSSRNLATAADQSAVDQGSYGSFEAPAYNPERYYDQQLSSFFSPLARDFDPSSLIIVNDALQTKPKVLRRVKGLGGDEDEMLANFDLSLRLHRYDRAAILLSRLRGCYPVASSKYLALHNRYLEGMVGQMILTRQHNLVLPMQKFFEVDLPASGVIPDATTYAIMIRMALRMFHGTKRDRAVRRYWDFAKKASLEEDVLAAPVLSELEIGELSEICSSDIQRVSMGSLEADKTLEGNRQSDTLDDVPDIKAVEQKGLGLSSLKESLSLFSNASRVSVPAEGEYSPEEAQELYNLSRQRQLEADSIQAALNRWRQENTDRKKAGLDTTGSEKRLGNIINQWHTDLVTRIDQELKLVEEAESKPPRNLEDTERCEYGVFLRCVDADKLAALTILSVLSSFGRGGMDSGLKLASLATSIGSELHDEFLAERTLQKEAAADAGRVRAVKQTLALRKQKDGRPRWHTIVRNLEKDDPTVAWSPRVKAKVGAALMSFLFEVAKAPVKIENPESKKTEMSMQPAFQHAYQITWGRRAGFIHLHPAIVKIVTKEPTSDLLGRHLPMLCKPRPWKGMNDGGYHVYKSHLIRTTPGETLQPAYVKAALENSGLEQVRHGLDILGTTGWVINEAVFNVMLEAWNSGEPVADLAPLEPDLPHPPKPTPEEGYEAEKKWDNDMREIENRRAGFHSQRCFQNFQMEVARAYKNDTFYLPHNLDFRGRAYPLPPYLNQMGADNARGLLLFSVAKPLGASGLRWLKVQIANLSGFDKASLSEREKFTMDHLDDVLDSANNGLHGKQWWLKADDPWQCLAACCELRNALQQADPTQYASRLPIHQDGSCNGLQHYAALGGDKIGAQQVNLEPSDRPSDVYTGVAEFVKEAVSREAAQGHSVAKFLDGKITRKVVKQTVMTNVYGVTFMGAMKQVRKQLIDHYPELSQDQKHQGAIYIARKVFEALGTMFNGAHDIQYWLGDCASRITQSLAPDQIEQIAKEAMTPESAKTMEDPTKKFRSTVIWTTPLGLPVVQPYRVRKARRIYTTLQDLSIVDGSSGDVVSKRKQLQAFPPNFIHSLDATHMMLSAIACHRAGLQFSAVHDSFWTHACDVDSMNELLREAFVRMHSDDVVKRLAAEFEVRYSQNLFLAKVEATSPLGQKVRALRKGSKVSQKATKVHEMLEEHKRQKLLRSDDPELQAQGRAMVTPGSIFEEFGSDEDLAIASSLGETAVGHVPEDLAAAERKISGMEADPTDPAIESLFQGFDNVLGAKADPHDDTPPEEPAPTKRKAKAKTYVHIWLPLRFRPVPTKGTWDVTRIRDSKYFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLY1</accession>
    <name>A0A317VLY1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_524293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463973.1">
        <property type="nucleotide sequence ID" value="XM_025610258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLY1"/>
    <dbReference type="STRING" id="1450535.A0A317VLY1"/>
    <dbReference type="GeneID" id="37112401"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="72"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY75346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="417" mass="48104" checksum="CE5782189134A97D" modified="2018-10-10" version="1">MASILRLPSRFSRAISPWRSWAHRHASPVRAFSQSNFPLLDPAEKLEEESLSWYSPRNFYPVKIGEVFQSRYQVVGKLGYGGYSTVWLCRDLQQHAYVTLKVFERNSAEGQRETEAYAHLNSLNIVDHAGAKLIRKALDTFIITSPDGNFGCLIHPPLGMRLYDFRTQLRAKVLPEKIVKLTLVHLLLALDYLHTEAGIVHTDIQEKNIMMAIEDPSILTDFEEQEKSHPSPRKILDDDRMIYASRKLKKTKQHGRPTLCDFGQARFGSHTYSDDIQPWVYRAPEVVLRLPWNEKVDVWNVGVLTWDLFQQSHLFYGRDLNRKPSDGHHLAEMVGIVGLPPREMIRGSEYAVEFFDGEGNWKADIKIPTESLEMLEGNLSGESQQLFLRFLRKMLTWKAEERASARELLDDPWLRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VN25</accession>
    <name>A0A317VN25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_606936</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463680.1">
        <property type="nucleotide sequence ID" value="XM_025616531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VN25"/>
    <dbReference type="GeneID" id="37118674"/>
    <dbReference type="OrthoDB" id="2117718at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY74487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="496" mass="55688" checksum="83B1B4758A5AAC05" modified="2018-10-10" version="1">MEESPIRLRCIGVIPSEGPAEITAPGAVSPEIRQRLQDSLVSSLLKSCPADLWPGTMYLSNCPFPMLVTRNHLASLASLNKVLVTAIDDIVTRWVDPSANFPARMPLHPVEERLLQWLDDAQHTGIIRPFRECRGSWRPDFLIEEQGGTEDRPEAFRICEINARFCWNGFMMNALGQDALVDTGISGHELVGATDSQSLFDGMHRLYNPRLPLHLLKDQEPGVDIHLYTHYARHLGQQVRFITPADLRLIPCNRSPGNKLCCLVHSRSPIKGDNFQNEAGEILEEVHQIQLELHHHELLDLGYEMLQEISLRCFNDMRTLLLVHDKRMLGVVLEEIDSFVARKVLTPQEASLLERGICETILPGSNQLAQLIERCRLQCGLKDEWLLKPARSGKGEGIVFGRDMTPESWISRLKELICPFMSAGGATYVIQKKVRQAKYDVLLKDATEVQQLPIVGTYHAINGEFLGIGTWRSSPGPVCTVSHGGTWMCSVMQAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNW3</accession>
    <name>A0A317VNW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_568723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463751.1">
        <property type="nucleotide sequence ID" value="XM_025614699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNW3"/>
    <dbReference type="STRING" id="1450535.A0A317VNW3"/>
    <dbReference type="GeneID" id="37116842"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF8">
        <property type="entry name" value="PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY74558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="521" mass="56603" checksum="7C7177A6382B6052" modified="2018-10-10" version="1">MSEASKDVFGQGTEEDLTLEHLGYQQEFKRSFGLLDMIGFSFSIVTCWSALSGVFIVGVDAGGPPVMLFGWIGVCVLTFAVAVSMAEWCSRWPVAGGQYSWVFLLAPPKIARQMSYITGWFMLMGILAMGSANNSFAANFILGQANLVYPEYVIERWHTVLVTYAVAIWTLMINIFMPHLLNRLSRAILLWNVCSFIIIVVVLLATKTDKQDAAFVFQDFQNTTGFGSAMATMVGILQSFFGMCCYDTPSHMTEEMTHASRDAPKAMIMSVGMGAVTGFVFLLTLCFCIGDITATANSSTGVPVIQIFYDSTQSKVGACFMASMMTVIMIVSGVSLVAEGSRALFAFARDRGMPRKIPIYAILFTVVVQMAFNSIYFGTVTGFNTVVSIATTGFYVSYGLVLLARLLGYFFGHDVAPVDSPYSLPLPISLSLHGLGFLFLFFAFITFNFPSDAPVTPDSMNYTSAAIGLVALLSIFTWFTTARKQFKGPADVQGLVLDGVEQPVVAGEASAGLSEKVNLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNY5</accession>
    <name>A0A317VNY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463771.1">
        <property type="nucleotide sequence ID" value="XM_025612553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNY5"/>
    <dbReference type="STRING" id="1450535.A0A317VNY5"/>
    <dbReference type="GeneID" id="37114696"/>
    <dbReference type="OrthoDB" id="5375886at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="73" mass="7686" checksum="896D1A3A4BB4C749" modified="2018-10-10" version="1">MSAPNAGRQSPSPERQTGAQQQDPPSQGKAQPQYAPPEDSVQDQASQTAGLSSNPKHPLEDIESEKFTKGGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPL0</accession>
    <name>A0A317VPL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_538832</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463542.1">
        <property type="nucleotide sequence ID" value="XM_025612572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPL0"/>
    <dbReference type="STRING" id="1450535.A0A317VPL0"/>
    <dbReference type="GeneID" id="37114715"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="5">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY73790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="111" mass="13012" checksum="5D083CD73AF392A8" modified="2018-10-10" version="1">MTYDPSVVSYRSLLEFFYRMHDATTLNRQGPDVGTQYRSVIFTHGDEQEKIAHDVTEKVSKEWFKQPVSTVVVPAGQWWDAEEYHQLYLNKNPEGYECPAHFVRNFPPLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPZ0</accession>
    <name>A0A317VPZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_499069</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464247.1">
        <property type="nucleotide sequence ID" value="XM_025609361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPZ0"/>
    <dbReference type="STRING" id="1450535.A0A317VPZ0"/>
    <dbReference type="GeneID" id="37111504"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY76434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="565" mass="61149" checksum="8D15B963619593E5" modified="2018-10-10" version="1">MAFAGQAPTIIVLKEGTDTSQGKGQIISNINACVAVQSTIKSTLGPYGGDLLLVDGNGKQTITNDGATVMKLLDIVHPAARILTDIARSQDAEVGDGTTSVVVLAGEILKEVRELVEQGVSAQTIVKGLRRGSAMAVNKIKEIAIDMIDAAGSEEKKVETLRRLAGTAMNSKLIKRNSDFFTKMVVDAVLSLDQDDLNEKLIGVKRVTGGGLQDSLFVNGVAFKKTFSYAGFEQQPKYFKDPKIVCLNVELELKSEKDNAEVRVEHVSEYQAIVDAEWQIIYNKLEAIYKTGAKVVLSKLPIGDLATQYFADRDIFCAGRVATDDMDRVCQATGAATQSTCSDIQERHLGTCGTFEERQIGGERFNLFSECPAAKTCTLVLRGGAEQFIAEVERSLHDAIMIVKRALRHTTIVAGGGATEMELSSFMHGFADRNVPHKQQAVVKAFAKALEVIPRQLCDNAGFDATDILNRLRVEHRKGNTWAGVDFDHEGVRDNMVAFVWEPSLVKVNAIQAAVEAACLILSVDETIKNEESAQAQAPTRGLPPGAAQRALGGGRGRGMPRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VS75</accession>
    <name>A0A317VS75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_538046</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464373.1">
        <property type="nucleotide sequence ID" value="XM_025612402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VS75"/>
    <dbReference type="STRING" id="1450535.A0A317VS75"/>
    <dbReference type="GeneID" id="37114545"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="50"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY77186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="372" mass="40284" checksum="CE7B7BBA5AF34773" modified="2018-10-10" version="1">MPLISTTEVSEDTRVLGYDPLLSPQFLQTEIPGQKHSLEVVRSGRNQAIEIIEQRDDRLLVMVGPCSIHDPATALEYAARLKELSDKLSSDICVIMRAYLEKPRTTVGWKGLINDPDIDESYNINKGLRVSRQLYSDLTGMGLPIASEMLDTISPQYLADLISLGAIGARTTESQLHRELASGLSFPIGYKNGTDGNLTVAIDAIGAAAHPHRFLGVTKQGLAAITKTSGNEHGFVILRGGSKGTNYDRESIKAARESLRGKKQREVVMVDCSHGNSNKNHRNQPLVAKEVADQLREGQDAIIGVMIESNINEGNQKVPAEGPSGLRKGVSITDACIDWETTVTVLEDLADAVRARRAAKIAQAKASNGASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTA6</accession>
    <name>A0A317VTA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_498419</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464342.1">
        <property type="nucleotide sequence ID" value="XM_025609346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTA6"/>
    <dbReference type="STRING" id="1450535.A0A317VTA6"/>
    <dbReference type="GeneID" id="37111489"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001380">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000841">
        <property type="entry name" value="Checkpoint kinase 2-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="182"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="273"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY77155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="649" mass="72772" checksum="D4F5C6EEBFF99C6E" modified="2018-10-10" version="1">MTPQNEKSSLKRGRAIADNDLQYLKKPRRSERINSRSISQALDSQSYLPTPLTQRESTATDSGKEATAPPNGSSQVLHRRTPSNSEPLHASSSPPGDTQALSQFVYPPRAFADEVEDEAAEGVWGYLIPLDDKVRHALVLRKRGSCEERTNTEPTTKARKGAPRKSKDSVHDQGHFQSPGGYLIGRHHECDLVINIPTVSNRHFLIFPETRKGDAVAILEDLSSNGTFVNDAIVGRNNHRELEDGDEVTILDEARFVFRYPRTRDTNRFLQQYRVLQQLGQGHFATVYLCIERATGTRYAVKVFERRSSDSQRSQTDILQQEIGLLMGVSHPNLLCLKDTFDESDGVYLVLELAPEGELFNLIVSKRKLPENETRHIFLQLLEGLKYLHDRGIVHRDIKPENILVTDKKLTVKLGDFGLAKIIGEDSFTTSLCGTPSYVAPEILEESRHRKYTKAVDVWSLGVVLYICLCGFPPFSDELFTPDRPYTLAQQIKHGHFDYPSPYWDAVGDLALDLIDRMLTTNVDDRITVDGCLEHPWVTGNYPTASDSTDGLTGALGKLDFSKRKLSRERTLLSNINNVLYSEHEQETGAPVKVFRGNDAGKRVHNYPASITQEREASPNENSAPKDFLNLGTRGDPILFDHKAANGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW13</accession>
    <name>A0A317VW13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulose-binding GDSL lipase/acylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_603493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464833.1">
        <property type="nucleotide sequence ID" value="XM_025616441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW13"/>
    <dbReference type="STRING" id="1450535.A0A317VW13"/>
    <dbReference type="GeneID" id="37118584"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016441935" evidence="2">
        <location>
            <begin position="22"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="302" mass="33033" checksum="A133D4A58C353AB3" modified="2018-10-10" version="1">MKLQPSWLLASTLSTAAIAAARPWTRADNTTSPIYFFTFGDSYSQTGFSTSSTQPSASNPMGNPDLGIGTTTNGPNWIGYLTTTQNASLVLSYNLAVGGATIDNSLVSAYAGDVSSQVKLFEDVYSTKPASTAPWTADNAVFGVWIGINDIGNAFYKTDAETYTPLLTTRLQALMQEVYDNGGRKFLFLNVPPTDRTPMFIDQGSETTAAVGAYLGVYNRNLKDMVERWGRERGDVITVFYDAWSFMTKVLDDPTAYGFPDATCINDDGTSCVWWNNYHPGMKYHALQAEDMKKFLGSLGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW69</accession>
    <name>A0A317VW69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_588272</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464862.1">
        <property type="nucleotide sequence ID" value="XM_025615873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW69"/>
    <dbReference type="GeneID" id="37118016"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="172" mass="18363" checksum="D039C33A1575D6F1" modified="2018-10-10" version="1">MTEYSAAFSATAESTSVSSEPKQPEAFMQDILGSDGSQQQQQHHLLHPDPKAQTASTLPIWFQAIKGTSAIHSGVMNLPMIISFVIASVSGGLWPHQVDRLPGDPGAGEQNIAKEVPSIDPETVVNVGVMALYHVVIVAYNRAMTHTFYVGVAMACLSVLGAVLEWVYISAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYM4</accession>
    <name>A0A317VYM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_165157</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464945.1">
        <property type="nucleotide sequence ID" value="XM_025605902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYM4"/>
    <dbReference type="STRING" id="1450535.A0A317VYM4"/>
    <dbReference type="GeneID" id="37108045"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000596">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="218"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="480"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="589"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY79373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="680" mass="73336" checksum="CBD8D0D1517B5D8A" modified="2018-10-10" version="1">MAAPTQLAYRTVKGIGILDAAPVYEPLSGFEKPEGNLRCSAYSPCGRYFAWASPEKVTIVDPSVGTIVSTITADNVFELGFSPLGTYLITWQRPTKDANGDTTKNLKVWQVVQSSSDSNGDANVVVGSFVQKSQTGWNLQYTSDERYCARVVTNEVQFYQSENLSQVWNKLRVEGVTDFAVAPGKNHSVAVFIPERKGQPAAVKVFLVPQFGSPVSQKTFFKGDKVQLKWNEQGTTLIVLAQTDVDRSGKSYYGETTLYLLSAGGGFDSRVDLDKEGPIHDVTWSPNSKEFGVVYGYMPAKTTIFNFRGVPKHTFALAPRNTILFSPHGRFVLVAGFGNLAGQMDIYDMDKNFHKIATVEASNASVCNWSPDGQYILTATTSPRLRVDNGVRIWHVSGALMYNEEMHELYDVAWRPQSLTQHPLGDPFNPLPTPHPSAAAYLSTKKAPVKPAGAYRPPGARGQLTPLAFKREDQGGAVFIRDGASGGATVHTTNGFGRTRRREVPGAEPAEEFLPPGAAPGGGVALPPGADQPEKLSKSAARNKKKREAKKQKDGEDEEASPNRRGDKGHHERNRSKGQNERKNGGQANGAAPSAKANANASNAAAAAAAAAAAAEAAADASGAPTAQDKKIRGLLKKIRAIDELKMRLAGGEKLEDTQMKKIQTEEAVRKELDGLGFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W018</accession>
    <name>A0A317W018_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_537792</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464901.1">
        <property type="nucleotide sequence ID" value="XM_025612352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W018"/>
    <dbReference type="STRING" id="1450535.A0A317W018"/>
    <dbReference type="GeneID" id="37114495"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF16">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY78592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="315" mass="33674" checksum="0E69212363A02844" modified="2018-10-10" version="1">MASAIGKEGVFQPPKAAQAQDKPGLEKKMAPASEATKLESSGTFVEYVGSGKLKDKKALITGGDSGIGRSVAVLMAREGADVTIVYLPEEEEDAQDTKKMVESEGRSCHLFGGNLANRETCRKAVEEHMSALVALISVCPGYFADNSRSYKKLNILVNNASKQYMCKDFAQIDLDNVVDSFESNIIQMFAITKFALPHLSKGDSIINTTSTVAFRGTSGMVDYSATKGAIVSFTRSLSAQLKPKGIRVNAVAPGPVYTPIQVDTREAEQMEDFGSGSSIGRPGQPSEVATSFIFLASADAALFYGQVLHCYPLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1C7</accession>
    <name>A0A317W1C7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_521446</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465305.1">
        <property type="nucleotide sequence ID" value="XM_025610148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1C7"/>
    <dbReference type="STRING" id="1450535.A0A317W1C7"/>
    <dbReference type="GeneID" id="37112291"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY80446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="347" mass="39857" checksum="C94FD161B8B63B52" modified="2018-10-10" version="1">MSATTTRADFEAIFPSLREDLLDYAKQYKLPQNAVEWFEKALNVNVPGGKLNRGLSVPDTGSALLKQPLTDEQFKHLSLLGWLTELLQAFFLVSDDIMDGSITRRGQPCWYRHTGVGLVAINDAFLLESGIYIILKKYFRSHPAYIDLVELFHETTFQTELGQLCDLITAPEDNVNLDNFSMEKYMFIVTYKTAYYSFYLPVAMALHYLQLATPENLRQAHEILIPLGQYFQVQDDYLDAYGDPAFIGKIGTDIQDNKCSWLVNQALQRCNAEQRKVLETAYGRKDSELEAQVKAIYKELDLEKVYKEYEEEVVGELRTKISNVNESEGLKKEVFEAFLAKIYKRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2H0</accession>
    <name>A0A317W2H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_471535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464950.1">
        <property type="nucleotide sequence ID" value="XM_025608384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2H0"/>
    <dbReference type="STRING" id="1450535.A0A317W2H0"/>
    <dbReference type="GeneID" id="37110527"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="427"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY79378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="497" mass="52693" checksum="D0E3F809E090732E" modified="2018-10-10" version="1" fragment="single">PNPSLPSYPSTSSKPPAVTFPSMPFQFRPVAQTPPASLTPDLDDTASSDDQSVSDPFHQPSYATDEADEDAEEDEQPDVDDLNPKRTYQVAQPPPGADDRSQPSIRTVPDPALSSRGPAPPAAVTAPVQRSIHNPPVDLEQVGPSRESAPVAGSTVSTRSFTSYGGTRTPDSSSTDVSRPSDLRPAPASRAGSGLPLSSDICSRPLASRPGNRDRIPPPPPKSHHGKRIALSPGIAPALTQTTPGKSTSRFSFHGSPSEPSYSRRPSQSGSDYFSAQPRDEPAPPQPAESLRRSQSQNKRPPTPPLSRRHSQMRRSKTTMSKVNPLRLSIHAAQESTAASSPPPSPGSWSLNPARTRESRTGSTPSEEPMDSATSSLRPEPSSATPAAATPLSPTELSPSTPAGTSTKRTSLYNPLPPPPPPRRSRGSSNHSNDSSGLSLRSGKPVDKIPTAAAPVPAEVEFIPHPSNANDILADLTRLQKEVDDLRGHYESRKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5M3</accession>
    <name>A0A317W5M3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_152620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465523.1">
        <property type="nucleotide sequence ID" value="XM_025605811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5M3"/>
    <dbReference type="GeneID" id="37107954"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016357141" evidence="1">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="144" mass="15890" checksum="7280DBA950A56188" modified="2018-10-10" version="1">MVASINPKQPCWLFHVLFSSMHLFQAVRVPPPIRQTVIQQGVAGIENQTPRIYAAGEEGRRDKSELEDGPVRWKCFLELTEWCGVDPNCTGSSGGQRVNLPFSPTPLSNQTDRSVLDLQLPQPYKTLKPGPDTKDSLVSVAGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W769</accession>
    <name>A0A317W769_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative isocitrate/isopropylmalate family dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_602261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465460.1">
        <property type="nucleotide sequence ID" value="XM_025616420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W769"/>
    <dbReference type="STRING" id="1450535.A0A317W769"/>
    <dbReference type="GeneID" id="37118563"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF2">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="2">
        <location>
            <begin position="10"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="364" mass="39423" checksum="56654339B8D1B6CC" modified="2018-10-10" version="1">MASNGVQKYKIASIGADGIGPEVVNATIHVLKAMQGILNTFELEFTELDWGTARYKKTGRYMPEDGLDILRKFDAGLFGAVGAPDVPDHISLWQLLLAIRGPMQLWANVRPVKNFPNVPSPLSGVKDGDIDWVLVRENSEGEYCGQGGRTHRGQPWEAATELSIFTRVGVERIMRFAFDVARSRPRKLLTVVTKSNAMRNGMVLWDEVALEVSKEYPDVKWDKVLVDAMTVRMVNNPKSLDTIVGTNLHMDIISDLAAALGGSIGIAPSSNLDPTRKNPSLFEPVHGSAFDITGKGIANPVATLWSASEMLLWLGEKTAADILLQATEQTCSLGICTPDLGGKASTVEVAEAVIAQIRKIAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9J4</accession>
    <name>A0A317W9J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466061.1">
        <property type="nucleotide sequence ID" value="XM_025612098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9J4"/>
    <dbReference type="GeneID" id="37114241"/>
    <dbReference type="OrthoDB" id="4158841at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="259" mass="28013" checksum="9320BBB5456D333D" modified="2018-10-10" version="1">MDPPLRMDPKMDPKMDTRKISAQRLPPPVLFQGPPSHNASNLSLPPPVSAVPTAGTSPRPPLQRNRSSRGLDAPGSLSPFLSRKQSKGEVDGSEAIWQEMQSALSEVELSAATGEHVFGERHSEALEDLRTKQLKLAQAWARSEAGDEVVEAKGAPVAKSNASLRPASRSTAGAGESGNAEDGASRNLDEETEKDILLARERREANDRYFDRVNNGVLDVVAKLEEVAQAMRAVERESKDIWSDTDSMSTTTQTTTDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9R6</accession>
    <name>A0A317W9R6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_520500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465786.1">
        <property type="nucleotide sequence ID" value="XM_025610113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9R6"/>
    <dbReference type="STRING" id="1450535.A0A317W9R6"/>
    <dbReference type="GeneID" id="37112256"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040586">
        <property type="entry name" value="FxSxx_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="266"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="631"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="799"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="882"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY81718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="945" mass="106269" checksum="76F49733BD40A7A5" modified="2018-10-10" version="1">MLPRIIPQSRIMVYNYDSRWHMDAPKTRLQLCGEELVHSVHRFRNGINRPIIFIGHSLGGNVIQHGLLFADNHDQFSYMPSVTVGLIFLGTPFRGSKMQSYANIAVQSLAMMASHGGIIQDLTYDNPALTDRLHAFCNLQRKERLPTCCFFKLRETSYGRKLGVPGWAKGMVVEETSACITGLKRFPLQSDHLALNKFQGPDDRSFLSVSDEIRGMVMNSTDLIQQRKLVLSQHHWMVPFGRNRDFTGRESVLEPLHTEISPFSDEDACQRTAIVGLGGIGKTQIALESAYRLRKYCSVFWVPAVDAMTFEKAYREIGEKLGIPGINNGKNDVKRLVKDALSRDSFGNWLLIIDNADDPDLLFGKAALSEYLPSSLKGSILFTTRTQQVVQRLDISPRNTINLGEMTKGESVELLKKLHASAHDDHESVESLLDLLVCLPLAIKQAAAYMGETGVSVAQYLQFCRSSDKAQARLISKDFGDQYRYTEIENPIATTWIISFRQIERDKPAAATYLEFICLLGEREIPLSLIPYEGDEMDVAEAVGILKAYALITEHEEPGLYDIHRLVRLAMRAWMDRKGTLEKYSIDLLQWISDIYPKPEYDNKHIWGRYLPHAESLFSSCPHGKHDEVHEQLLSKIGVCYASLGKYKEAETMLRRALQATEKGQGPEHPATLANLIRLGGSFFDQGRYQDAEIMHRRALQGSEKILGPVHPCTLSSMVCLGNDLERQGRYKEAETMHRRALRGEVKVYGLEHPGTFSTLNNLNNALLAQGQYKKAARTAQRVLQGTEKVLGPEHPSTLASIRNFGKILVQQDQYEKAEEMFRRAVQGGEKLFGPQHPKTLSFLHNLGVALGLQGQHKEAELIFRHVLRSTEVLQPNHPDILLTYDDLGVALLSLNQYEEAEQVLQQAVQSAEKALGPEHSYTLLAAENLKLALERQGKPTLGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCI8</accession>
    <name>A0A317WCI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mago nashi protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_469475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465862.1">
        <property type="nucleotide sequence ID" value="XM_025608289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WCI8"/>
    <dbReference type="STRING" id="1450535.A0A317WCI8"/>
    <dbReference type="GeneID" id="37110432"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18867" checksum="E768987DC8EF2E1D" modified="2018-10-10" version="1">MTTPGDPFYLRYYSGHSGRFGHEFLEFDFRTIGDGRSAAVRYANNSNYRNDSLIRKEMCVSASMIQEVKRIIKESEIMKEDDSKWPQKNKDGRQELEIRLGNEHISFETAKIGSLVDVTESADPEGLRVFYYLVQDLKALIFSLISLHFKVNPAHSLLWELRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDK3</accession>
    <name>A0A317WDK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_536618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465923.1">
        <property type="nucleotide sequence ID" value="XM_025612054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDK3"/>
    <dbReference type="STRING" id="1450535.A0A317WDK3"/>
    <dbReference type="GeneID" id="37114197"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="124" mass="14506" checksum="AA9C4C733A29B855" modified="2018-10-10" version="1">MSSKVKAGQLWGKSKDDLTKQLEELKTELSQLRVQKITGGASSKTLRIHDVRKSIARVLTVINANQRAQLRLFYKNKKYTPLDLRPKLTRALRRRLTKHEATLKTERKRKQEIHFPQRKYAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEM3</accession>
    <name>A0A317WEM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466644.1">
        <property type="nucleotide sequence ID" value="XM_025611987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEM3"/>
    <dbReference type="STRING" id="1450535.A0A317WEM3"/>
    <dbReference type="GeneID" id="37114130"/>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040841">
        <property type="entry name" value="Luciferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17648">
        <property type="entry name" value="Luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="141" mass="16005" checksum="CC20C3937124CEE3" modified="2018-10-10" version="1">MWYIQTLVTSFYALADRNPDIIKCAKSELELHADAIFLATESLINRNEKTRQLKGECVHIHRLKDYSLHMVLSPVDFFDAGWGQRHGFSGVKIPRPLTGGRQIDLPSEYLLIYAPRTKEEVTLVMGLISASLRYLTGAEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFE4</accession>
    <name>A0A317WFE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_536257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466590.1">
        <property type="nucleotide sequence ID" value="XM_025611971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFE4"/>
    <dbReference type="STRING" id="1450535.A0A317WFE4"/>
    <dbReference type="GeneID" id="37114114"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000149">
        <property type="entry name" value="MFS transporter, SP family, general alpha glucoside:H+ symporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF56">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="63"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY84665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="570" mass="63197" checksum="AA65A5B2F25FDA3B" modified="2018-10-10" version="1">MASSKAPDAIAPVEQPPSPAMERQDSTTSSSAKIIQNAKAATDKEQKMTLLQGIKLYPKAVAWSILISTCIVMEGYDISLVNNFYAFPQFNRKYGELSADGTYQVPARWQSGLSNGAYVGEIIGLFINGWASERIGYRYTIMACLVLITAWTAIFFTAPNVQTLLAAEILAGIPWGVFQTLTITYASEVCPVALRGYLTTYVNFCWGLGQLIGIGVIKGMINRDDQWAYRIPYGLQWMWPLPLFIGISLAPESPWWLVRKGKTQEAKKALLRLTSVNRETNFDADETISMMVHTTALEKKITKGASYLDCFKGSDLRRTEIVCMVWAIQNLSGNSFSNYSTYFLEEAGLSTDDSYAFAMGQYGINMLGVFGAWFLMSLGLGRRTLYLYGLCGLCVMLLIMGFLGLVPQEHKTQAALATGSMMIIWALFYQLTVGTVAYSLVAEISTRRLQIKTVVLGRNLYNIVAIICGVLTPYMLNPGAWDWGNYAGFFWGGICFLCIVYTFFRVPEPSGRSFAELDLLFERGVSARKFAQTQVDVFDETMEHGAVDHFQTEKTATADVAAVEKGPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WIV5</accession>
    <name>A0A317WIV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen2</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_535548</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466985.1">
        <property type="nucleotide sequence ID" value="XM_025611810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WIV5"/>
    <dbReference type="STRING" id="1450535.A0A317WIV5"/>
    <dbReference type="GeneID" id="37113953"/>
    <dbReference type="OrthoDB" id="10249562at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000007">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016589">
        <property type="entry name" value="tRNA_splic_SEN2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011789">
        <property type="entry name" value="tRNA_splic_SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="7">
        <location>
            <begin position="349"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR011789-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY86394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="485" mass="54700" checksum="F8354911E110E108" modified="2018-10-10" version="1">MASSNPIPSPAPEAAAPGKPESSQNHASPARRPRPSRPNYRLIHRFPFPVEVHPLPPLIPHNPLSLVSVLLSYLTYFISPPHQEVYSAYFDSATSSIHVTDPKAIKALWEMGFFGKGTLSRSEPSWLEREKKRRGLLGGMTSEEVTRQRRTERRELKLERARMEKLAIEERLKAEAAAREGGVMPTEQSPLSPTPNGVTEGTTPVTEKFSLRKAREARLLESQRAVSQDGSAHPLNSPGKRTPSGSKTVRFSPVVQAKEFVSDSAILSLPETSVDGREANEEPVLNNEEHLQLSTEEAFFLVYGLGVLRVLDDTRTDAIPTSSLLPLFCRNSYFPPRDPSADLTPDDPFMISYVVYHHFRSLGWVVRSGVKFGVDYILYNRGPVFSHAEFAVVVVPSYGHSYWSETAERRAHCEEKMARSWWWLHCVNRVQAQVKKSLVVCYVEVPPPTSYELDTPCEEDIGAMLGRYQVREMVIRRWVPNRTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ26</accession>
    <name>A0A317WJ26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ulp1 protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_535615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467047.1">
        <property type="nucleotide sequence ID" value="XM_025611831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ26"/>
    <dbReference type="STRING" id="1450535.A0A317WJ26"/>
    <dbReference type="GeneID" id="37113974"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="7">
        <location>
            <begin position="713"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="373"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="565"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="823"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="890"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1176"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="615"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1178"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY86456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1249" mass="139866" checksum="E962DA17EEC59A72" modified="2018-10-10" version="1">MSLFGKLSDIFTRRSPRRPVLSPQNTPHPVPPSDATSDHIQRTETSGAWNAGSPLESHSLHTSFEGTFPSTSASSNAEGLRHNCELRPVRPQYRQTVPRSESGMRRLTGETTHAKLRRTPESKDEARLFFSSKRKDPAGVPVVPGQARNNKPKSPYAPVDRISKARDSGPVRAQGKQRHSRDDQAENAAGYPRSERPSKRRRQGSLEGYLREKPRNFPDNDVAEHPAQEAHRIADHPSRMSPTLSQNAGKTKKQRNNRRGEVKEYRSVEKYIKLPRIQPSPKRGAPKPYAGASSDDDRDERFTENATKERRRISSLLSEMDSGHKPERPLKPEVLESVEIINPRSPVLAMDAKWSPTLPQKSFKTDIGRNITESRESPDELQGAVTVRPPTLSEGARAELERHIATTGRQPSSQDIQPTIFESSQSKNRGKRKNKRAQPSETISTQQSFGAAFVRFGPTEHHASSLCQPLEIDVDKVKHMIALARAADLVDGFEVPLSKVISIVRGDSTSNKVRLNLNLPAVGRLIDIDFVSMPEKEGFCSLLSSVTSIQERPSEWMNKAFNKAQREHKQFPNGTKRPCSESGPEHVPDKPAPSTKRVKLTDALRDKNGVAVGRQPSTSERANPSTEPSQPEKSPARVSKRAAEPSVEIPVKKFAPSMSTRAMSRRPTSDPTTVVCDDSDDSDDDLAEQPVPEVHAKKWHKPLVYPLIGKKKAEVDVYDLERLRENEFLNDNLIGFYIRFLQEHLDRTNKEVAKKVYFFNSFFHDTLMKVPRGKRGINYEGVQKWTRTVDIFSHDYVVVPINESAHWYVAIICNLPSLQGIAEESPTPGELTEGEKEPSAPPDSQVREIFETPEPETTSHKDDEDGKAIDSEFAREELARQSLASMRLFDESAKEKSNEGSGVDEEWPEVEENPISPPKGLSTERLDAKTASQLPEPSAKPRKQKIKRGPKYDAFQPIILTFDSLNVSRSPTISSLREYLCKEAKSKKGIDINKNLIKGMRAQDIPLQPNYSDCGLYLLAYLEKFVQDPDVFVRKILRREMDQVNDWPPLRSGLLRHRLRKFLDALWDEQEQLKSQKMSDHETMADKKPICYLLGGPTSANVKYEQESSGAMKLSENFVPDSNHERHMVTGVEVDLNRENPTQTELVGEMTGSQPHTAGTLKQSAERDVVLVPDSQPEIASSNANPQPSKSPRRAPETDLQPRIVIDIKDVAEGEGPDTVTVVPVETQVRETPPRSSAPVRGSVEKSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WK81</accession>
    <name>A0A317WK81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_597074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467066.1">
        <property type="nucleotide sequence ID" value="XM_025616264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WK81"/>
    <dbReference type="STRING" id="1450535.A0A317WK81"/>
    <dbReference type="GeneID" id="37118407"/>
    <dbReference type="OrthoDB" id="121380at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34315:SF4">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016414712" evidence="2">
        <location>
            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="3">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY86475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="375" mass="41301" checksum="294EE9592EC8068E" modified="2018-10-10" version="1">MKSLLLASVFFLASIIEAHPGPHSQPDPVHLARRGALAKRCSDSVGLMKRNRHAMRRRDLSPSDGTTAYTITADAPKYDFLKNDTCILTPETSPGPYIYPRSQTLRQNLVEDQPGVPFVIDIGLMDIHTCEPLTNALVDVWHCNASGSYSSFTGLNPDVTFPEQYFESTGEEINADNGMSDVSINEKRQFLATDDTTWLRGMWPTDENGATSFTSIFPGFYTNRAIHVHVQVHTDWSVTANGTIGAGKTVNTAQLFFNDDLAAEIMTVPPYASHTQIPRKPVAEDGVYYAEASTGAMAIMDTEPLDGQDYKNGVLGYVTLGVDTTAIHNGTTENPMSRDPSRSQHPSRSYFTKFHQQSKPTGLIIRQETSDYSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKV0</accession>
    <name>A0A317WKV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_493466</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466665.1">
        <property type="nucleotide sequence ID" value="XM_025609203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKV0"/>
    <dbReference type="STRING" id="1450535.A0A317WKV0"/>
    <dbReference type="GeneID" id="37111346"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY85648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="126" mass="14099" checksum="0167E5A980C2C498" modified="2018-10-10" version="1">MGKRKKSSRQPAQPKKKEPLPTTFACLFCNHENSIVVKLDKKLGLGNLSCKVCGQRFQTGINYLSAAVDVYSDWVDACDAVAKDTATKYEESDVRVRRSNDFTTSANTRDTGFEDTDRVDAYADDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WND2</accession>
    <name>A0A317WND2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_493736</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466767.1">
        <property type="nucleotide sequence ID" value="XM_025609208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WND2"/>
    <dbReference type="STRING" id="1450535.A0A317WND2"/>
    <dbReference type="GeneID" id="37111351"/>
    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02670">
        <property type="entry name" value="Peptidase_C19N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="110"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="552"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="672"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="723"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY85750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="762" mass="85048" checksum="B568AC30D0E08BBB" modified="2018-10-10" version="1">MSGIHRFLTRREKKNSKEESNLLSRPHFRGFFSSDKIPTGDTNEEEKKIKILEQRVAQLGITGLKHEHFSYALQSEHAQGDVDKAFDMLMILEDAIEGIIRGYTPTTKLLGAVNREGVTCYLDALLFAMFARLDCFEAILYKSFNDEPRRKLSILLRLWVNLLRSGRLITTDLTKHLQDALAECGWEDAAKLRQQDTSEAFTFITEKLELPLLTLKMDIYHTGKEDVSGDHKFINERLLEVAIPEPVDGQTVTLEDCLESYFNNRIEVKRYLERRYTVGSTKSIDSLAKGCTTHVEAIEVGSPLSPCSSQSPSPLEEITPVASLTGVVDSDPPPYRRSSIVQERFFPDDIKAKDGAIVSHRRGSYRKEVMMPAWQFFSLIPWYTDNTPTNDAQVAAHFSSKRPILGMCLKRYSMSPSGKAVRLDTFIDIPTEIGLPHFIQDDSMHEEGPIYGNFKLSLQAMVCHRGNSVDSGHYISIVRGTSAGAPPASSHGPDQEMASPDASRYWMRFDDLAKERVTLVDIEQAMKHESPYLLFYQILPINEDAAAANLFDKPPSSEMSADSRESEAGIAQRLHKPSVDEIGGDGAEGYASGRPSFEITGPDGADPAPMGQNSRKQSVAFSEVFDPGSMQSYPSTSPRLTPRDDDGRGSFSFSRRSSRGTRSTPGSRAGSQASESRISTTFSRFTGRLSRDRFTGDGLTEGDGDELTETELGLGEKFAPPSSERKGRSPRRTKDSERVRDKLKDKSREKIGRKLDRECVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNG4</accession>
    <name>A0A317WNG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_517631</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467069.1">
        <property type="nucleotide sequence ID" value="XM_025610003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNG4"/>
    <dbReference type="STRING" id="1450535.A0A317WNG4"/>
    <dbReference type="GeneID" id="37112146"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016193158" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY86478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="554" mass="60787" checksum="0E2CE6394B14CBD0" modified="2018-10-10" version="1">MISSVFLPVIAAALLPTSVVTRRTNTTTAPTVQVRNGTYAGLYNPTYDQDLFLGIPYAQPPTDELRFRPPQSLNTTWNDTRPATAYYNECIGYGSDDWPWTDVVSEDCLALSVIRPHGINSSANLPIVFWLHGGEFAEGGTRDARYNLSYIVQQSVEMQSPIIGVTVNYRLSGWGFLYSEEVAAEGSANLGLRDQRLALYWVQENIASFGGDPSRVTIWGQSAGANSVGLHMVAYNGQNDNIFWGGIAESGAVPSLAAYMSASDSQPYYDAVVNATNCTGASNTLTCLRQVPTATLSSIFNSSLVAGAGYHPVIDGTFLTTSGITNLFTGQFTKTPLLIGTNFDEGTKYAPHSCNTTDQFLSLVQSNGTNYTSALTIASLYPDDPAVGIPGTLHGRPPPSYGYQWKRVAAFLGDLLMHSPRRLTTQSLARWNVTSYVYHWNVMTLGPLDGAAHGYEIPFSFHNYDYLGDEQGNANVTWPQLSTMMSRMWVSFINHLDPNYNNVTNVHWPAYTLDHPRNMVFDVNVTGLAYVEPDTYRAEGIGYITSILQSAFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNW2</accession>
    <name>A0A317WNW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PIG-P-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_492121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467856.1">
        <property type="nucleotide sequence ID" value="XM_025609173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNW2"/>
    <dbReference type="STRING" id="1450535.A0A317WNW2"/>
    <dbReference type="GeneID" id="37111316"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="7">
        <location>
            <begin position="193"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="356" mass="39431" checksum="52DC21C0C4F6BBDF" modified="2018-10-10" version="1">MSRLGNGEGESPEYLRNDSESPSVLSSFEPEQPFPPLPDDLAATTQSLQTNDYVDEDDHEPTSPSHADIDAEDDADFQSQYSLEDQAFSDASSDSEEQSPEDGLSMHHSFRQSTSSLNGPNAFAPPFYNRPPTPLPPSPSLTSLLRPPFSTTTSRPTTPDSSDVETPNDTEAAVAKSARRATTVPRASPKVPTYEYYGFVLYLASSLAFLIYILWSYLPSPFLHQLGIYYYPNRWWSLAFPSWLVMSIIYIYVALASYNTGYLTLPMKSMENIVDEVANVAVIDGKGRRRPGGAAKMRPGATSYQIMGPQNRKVNWKEIWSEGTDAVLDVPVGGVCEVLYGQERDDELCEELSTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQ81</accession>
    <name>A0A317WQ81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_452045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468016.1">
        <property type="nucleotide sequence ID" value="XM_025607544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQ81"/>
    <dbReference type="STRING" id="1450535.A0A317WQ81"/>
    <dbReference type="GeneID" id="37109687"/>
    <dbReference type="OrthoDB" id="6224010at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY88654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15747" checksum="9FE8649047D79077" modified="2018-10-10" version="1" fragment="single">MSSQEPQQSQPPRKTYNLRNPLPLSAAQESEVKQLYYKRVRSLCAPEIKAFAECAVNRTVTATWVCREQRLAMNACMVAHAKPEEEDRAREEWFSTHEERRRAKEAEVARVEKRRVEVIKMMREDEERRKKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQA8</accession>
    <name>A0A317WQA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_584995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467971.1">
        <property type="nucleotide sequence ID" value="XM_025615668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQA8"/>
    <dbReference type="STRING" id="1450535.A0A317WQA8"/>
    <dbReference type="GeneID" id="37117811"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY88609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="285" mass="30377" checksum="8537BEFDD0E57913" modified="2018-10-10" version="1">MTAASSTWLITGASSGLGKSLVLEALKAGHRVIGTTRDITKAKTACPEFSAKGGIWMELDPAQKDAQDQFAKCAQEYDVDVLVNNAGYAFIGGVEDTSEIEVRDQMEVNFYGPLRAVRGCLPVMRAKGSGHIVLISSGAGFIARPGRGTYSASKFAIEAMHESLSHEVRTLGIKILIVEPGAFRTPFSSRILTPALFKDGFSEGYKGTAVEQMISGSRQITSISDFAKGDPDKAAQAIIQATATGYDFLRMPLGTDCVVALETKIGELQRDLEATRSIAASTDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQB8</accession>
    <name>A0A317WQB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription elongation factor Eaf N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_57286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467654.1">
        <property type="nucleotide sequence ID" value="XM_025614943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQB8"/>
    <dbReference type="STRING" id="1450535.A0A317WQB8"/>
    <dbReference type="GeneID" id="37117086"/>
    <dbReference type="OrthoDB" id="125903at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019194">
        <property type="entry name" value="Tscrpt_elong_fac_Eaf_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09816">
        <property type="entry name" value="EAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Eaf N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="437" mass="47323" checksum="808850CB064DA444" modified="2018-10-10" version="1">MAAPALSTGGLIDPTKQAEYPVVLGDRLTGKNGSAQSQLVNIQYNYKTKSATARQRITRSRQSRDRYNLTITDKAPNADNVLTYSYQGSVDPAQAVSDSGEHNLVLVFDAARKVFVLEPVATQLHFNLRSAPAKSQKQVLEQYEQLRTLQEEDHGSGDDRASDNASGNDDGPADDSNPYDYRHFLPKENADDDKSVSDKTPEHPSYTSRVDTPLMSATKPTPSPRPRPVSRPNPLHSKKKSDGARPPKPAAARPRPRSPARPAQKSDGRKTIVEEEPPTEPSKFSPSDTGLGAVSSQKAIPSPGSNIIIDGDLIIDMGSPPPSRPFSINPAHFSSNNTPADEDNNEDDEDIEDLRLPSPAGHGGAPVASGGVNLEPGAGEDEDELEDDDALAAEMEAAFEESAREEEEARSQQSYTHAPSHQYHMASEDESEVSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQS5</accession>
    <name>A0A317WQS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavoprotein oxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_50830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468118.1">
        <property type="nucleotide sequence ID" value="XM_025609657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQS5"/>
    <dbReference type="STRING" id="1450535.A0A317WQS5"/>
    <dbReference type="GeneID" id="37111800"/>
    <dbReference type="OrthoDB" id="5369448at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="75486" checksum="614262D01D8EE24A" modified="2018-10-10" version="1">MDDYSSDPELTGYADCTGEASGIRRGAAYESPPISPAFSKSGLQHRYELYDEIDPFNEDTQILAHDGGYSSSGSSIRQSGDIPGGDLDGDLDRMSSRASSRSSVSSIPTSVLTNMADGMKTVLHNDMLSHHWENHDSKVHSKLEGQVRSIPAIRHRETAFRKPSSVKAMQMHTEDEGDDDFLTPPKRRGQRLSDVSMRSAGSSPLRKTQFYSPTGSAGKPKVKKEYPLVLLHCNLLPPSLPVPGAMGYHNQKVLREVLPSEYWRRWKLLEEKVGSVMLRERGVLISHPEDMYDLLEERLLESLDLQRPRLDHGHFLGQDENDSERDDQSVKESATDEEEGEDCPDCGGRVVRHSNAGRKWEIKVFAANGLMRAGAWAAAWREMEKVDVEVGLWLPSEIRRELERRLLEEEICQFENRLQVPHSQEPAHAMATEVRQHSLPAPTTPPAIEEHNRFVHEQAAMPSPPVTKKVAAQEQRMPEYRSVPRSSEDIDLQTLLVNYIRVLASDRRNVAIAVLSFLVVFCAIHATPQSTQSALRPFPQDILEPVSVSSSAVSLMQPSSTNWGRPTSCALPSVETSRTDVMPSFSSRISSSSGDAISSSVTTLSSSVVAAEDILGPVLDDPPNLQAEPEAGSSLENPLATLKPEPELSTVRLKDPGAPIVDFSMNLVTLTPPMSPLVEEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WS84</accession>
    <name>A0A317WS84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_595260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468257.1">
        <property type="nucleotide sequence ID" value="XM_025616219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WS84"/>
    <dbReference type="STRING" id="1450535.A0A317WS84"/>
    <dbReference type="GeneID" id="37118362"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF87">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016418044" evidence="1">
        <location>
            <begin position="18"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="101"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="369" mass="39378" checksum="CA74A83980B4A4FD" modified="2018-10-10" version="1">MHCSLWLALTFSLGAFARPRGVSPGCAEVAIPIPVAVPRYIINATVQTDWDAVALTLNLTRRDSGTVTDPLPVAGSTTAAVANNFTVAATLCQGPPGAPVLVLTHGIIESKLYWRPNFTDADAYSFVDAALKAGYSVLSYDRIGVGASSKVNSLFDAQFQVETAVLNSLTEYARQATKASRVALVGHSYGAYLTAASASQMAVDAVVLTGFSGTFTYFGPFLAGAGLRVARHHNPARWGMLDSGYLTSSDLFAETYVYFAEPYFEHRVAEWAFTTESEPFAVGELPSLLETTIEYGNITAPVLVLQGQFDVSACGGNCVGLLNSTKALFTAAKTVETVDNLPAGHNLNLHKVAPQAFDRIFRFLRAQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSG0</accession>
    <name>A0A317WSG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_623974</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467591.1">
        <property type="nucleotide sequence ID" value="XM_025617187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSG0"/>
    <dbReference type="STRING" id="1450535.A0A317WSG0"/>
    <dbReference type="GeneID" id="37119330"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="9"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY87808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="245" mass="27715" checksum="926464131894B373" modified="2018-10-10" version="1">MGVPENKYSVILPTYNERKNLPIIVWLLERTFRENNLNWEIIIVDDGSPDGTLEIAQQLRTHYGADHILLHPRAGKLGLGTAYVHGLQYTTGNFVIIMDADFSHHPKFIPQMIRIQAESDADIVTGTRYASLDGVKGGVYGWDLFRKFTSRTANLIADVMLMPGVSDLTGSFRLYKKSVLEKVIMSTQSKGYSFQMEMMVRAKAMGYRVRECPITFVDRLYGESKLGGSEIVEYLKGVVNLWLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSW7</accession>
    <name>A0A317WSW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_584715</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468367.1">
        <property type="nucleotide sequence ID" value="XM_025615647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSW7"/>
    <dbReference type="STRING" id="1450535.A0A317WSW7"/>
    <dbReference type="GeneID" id="37117790"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF6">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY89456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="261" mass="29341" checksum="57C439C2A4A882CF" modified="2018-10-10" version="1">MSFYKPEEKIFHNDGREQALLEYIQSHPSYDEMHGNPERILAAIDEFGREKDFLMNVGQSKGAIVVKMITDRNPRIMVELGGYVGYSAILFGNALRKAGGQKFISLEVSPVFADISDTLIRLAGLEDIVEIIVGPCRESLRALREVYPNRRLDMIFFDHRKVQYVNDLKLCEELRLVAPGTTVLADNVISPGNPAYLEYVRFSTKKKAEHARLQSSEGDQLEDLSTGDPFLVYDTLTVRGLEVTGVPDAVEVSYCLGFDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTD8</accession>
    <name>A0A317WTD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_43548</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468584.1">
        <property type="nucleotide sequence ID" value="XM_025607492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTD8"/>
    <dbReference type="STRING" id="1450535.A0A317WTD8"/>
    <dbReference type="GeneID" id="37109635"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF161">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY89673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="351" mass="39303" checksum="E2322DC9808686F7" modified="2018-10-10" version="1">MAVEYYNVFEFPIVRDQLIANTVLVALSTLAIGLRFFSRRIRQSKIWWDDACIVMSMLHTYGMLAMQYHYARVGMRHHYTDIPPENTILIFKMLVVYQIVYYNAMVFAKFSYLFFYLRIFVTRGFRIAARVCMGCAGAYWLGSTLQVFLICQPFAKNWDATLPGHCASMNVAFSTIGAFNLVTDVSIMALPVHHIWKLQMSTATKMALYGIFGVGSFISAITIIRIHVLTTVDFTDLPYSMIWAAFWSVTEPALAITNACVPMMRPVFKAAFPGVFSSAKAAYTSQTGAQSGASGSAFKRMRDTESEIPLTHLVPTKTGSRGVEYEPSLTERSHDGGSTHVPTSVIGEDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUB0</accession>
    <name>A0A317WUB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_464511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468244.1">
        <property type="nucleotide sequence ID" value="XM_025608068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUB0"/>
    <dbReference type="GeneID" id="37110211"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34882" checksum="5F2CA9A5610804E7" modified="2018-10-10" version="1">MPFEKPAFDDLPLDKTGPPGNAWGLFGPNDQCGMLNLLTSERTSAAAREIIDGVRISTDWALDRITTPAFDRAPFAQTISNKAPASVNDDILQFNTQTSSQWDGLRHYGYQKEQLYFNGRTLDDLLTSKVNGIHAWVENGGIVGRGVLLDYAAWAEANNVPLQAFTPQSITVAVLDEIAKAQGTELKPGDILLIRSGWGRGYAQLSQEEITALANAPLPPAIGLESSEATLRWLWHKEFAAAAGDMPSLEAWPCQDTKYWLHEWLLAGWGLPIGEMFDLEQLSEECRKRQRWSFFFSSVPLKVPGGVASPPNGVAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUY6</accession>
    <name>A0A317WUY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO94DRAFT_46783</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468020.1">
        <property type="nucleotide sequence ID" value="XM_025608224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUY6"/>
    <dbReference type="STRING" id="1450535.A0A317WUY6"/>
    <dbReference type="GeneID" id="37110367"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="18">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="19">
        <location>
            <begin position="142"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PWY88658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="292" mass="33765" checksum="C91CB48B884A1775" modified="2018-10-10" version="1">MANSKYEYVKSFEQPDVLLPNTWIVVRIDGRGFHKLSANYGFIKPNDRRALDLMNAAAVAVMKDLPDLCIAYGVSDEYSFAFHPSCQLFERRSAKLVTTIVSTFTAYYTYLWGSYFPDTPLQAPGLPSFDGRAVMYPNSRIFRDYMSWRQVDCHINNLYNTTFWTMVQKGGMDNRDAEQELKGTVSADKNEILFKRFGINYNNEEEIYKKGSVIYRQYQLEDVKVKSDSGIQEETSPLQEATPSKTQQDKLRKLRNKAQVVVDHVDIIKDEFWERRPWILSGKPGKLPVESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVG5</accession>
    <name>A0A317WVG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cholinesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_463345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468727.1">
        <property type="nucleotide sequence ID" value="XM_025608020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVG5"/>
    <dbReference type="STRING" id="1450535.A0A317WVG5"/>
    <dbReference type="GeneID" id="37110163"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="513" mass="56179" checksum="A250D5EDB53AD594" modified="2018-10-10" version="1">MLGLLRPRLTLTDDSLTNDSLTIQTANGAITGHVSTSHTEVLEFLGIPFAQPPIGDLRWEAPQKYHANNSYLANTFVTDAILCSDCPYARISLYTYPGETEQFPRIMKAFVASEGNNSQSEDCLTLNIWTRLPLQILKPVYVHFYGGRYTSGTANTPFYLGAGLASTQDIIVVTVNYRMNVFGFPGIPSLSTSNLGLLDQRAAIEWLRDNIEAFGGDANRIVISGQSCGGAMVDYWAYAWPDDPIVAGLISHSGTALSFGGNTLDLSARNWANITVQLGCHTAPDVLACMKRQSVSALLIAAGKIPTFSTGTVGRTLPAFEATIDNVTIFSDYETLSSKGRFARVPYLLGHNDNEAGFYKTAVYMQGKNLTAEQWQTFNENTFTCPTDFQAAHRVRFGVPAWRFRYFADWNNTRLYPTSGAYHGVDLNMIYGNSELFTGLPASAGQDQLTSRMQAAWAAFVIDPTAGLSKVGWPVFDLNNNTLICLGYNNQPGVALVNPSLYNRACTHLSNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW07</accession>
    <name>A0A317WW07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_623342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468972.1">
        <property type="nucleotide sequence ID" value="XM_025617144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW07"/>
    <dbReference type="STRING" id="1450535.A0A317WW07"/>
    <dbReference type="GeneID" id="37119287"/>
    <dbReference type="OrthoDB" id="5304511at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="52602" checksum="6755D813B27DA720" modified="2018-10-10" version="1">MRKIVSKLKRSLRLSRTEPVDPTNGSRRPRPSSVSDTAPGQSVLTGPPRDVPLETLPPEIRYLIMSMLELRGLQALVHASPVYHRQYLADRWRLLPRCLDVTLQSVAVEACFAYRSGMAEFSETRNPEAVIELLDLYQERRALFKASAWSQDLTADEALGMVTFHLSIVEPLVRRYAVWALGNLAQEPEVRQCDASLSKTEELRLLRSMYRFQLCCNLFGVGCHGTPFSPRSEFDSVSILKVFLSIFEPWEVEEIVCIYAFAKAKYNQIFDDIRWDVHEENPKFDGQRPPTPDGAFDLDNSWIRHSLLYGTISRGLRLLHTVFCNIRDHEHLVSTMQDRISWPAGSFLEHEALGQSAQTIRRRQHPSPRDSKEERRDPLPFQGDRVDDVYPPLAWTLMWRGTYSNLFGYYMEDPIRSWGYVMWDAARLEQSGAKKVLKRQWTAEWRGDDPRDQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWH1</accession>
    <name>A0A317WWH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_574595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468573.1">
        <property type="nucleotide sequence ID" value="XM_025615026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWH1"/>
    <dbReference type="STRING" id="1450535.A0A317WWH1"/>
    <dbReference type="GeneID" id="37117169"/>
    <dbReference type="OrthoDB" id="1641903at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042907">
        <property type="term" value="F:xanthine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006042">
        <property type="entry name" value="Xan_ur_permease"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00801">
        <property type="entry name" value="ncs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42810:SF2">
        <property type="entry name" value="PURINE PERMEASE C1399.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01116">
        <property type="entry name" value="XANTH_URACIL_PERMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY89662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="564" mass="60260" checksum="7463BCED1247F6DF" modified="2018-10-10" version="1">METKAIPVSTIEDETSSPTAREVVELSRWSYWKRYLTSWDGWIGEYDYMYLITPNVYPLNKRYKDTEPPFYGLNDEVPILLTIILGLQHALTMIGSVVSPPLALASGAFYLDSMQSQYLVSAAFITTGVATALQVTRVHIFKSPLYIGTGLLSVVAPTFDVIAVAMNYADTRYKNGSCPTDGNGSRLPCPEAWGAALGTTLCTVWIQILMSLVPPKALNRIFPKVVTGSLLLLVGVYLISSGMENWGGSSNCDGGTGYYALCPNIDAPKPLPWGDPKLIGLGFSVFVTIIFVEIIGSPLMKSASVILGLAVGCAISGATGYWSREEIDAAPVGTFLWVHTFPLSVDGALVLPLLIMFVCEAVSCMPDILATAEISRVDIEGREFHSRIQGGILCDGLGSLVSALGTSLPMVSQAGNNGVISMTGCASRRAGWCASAILLLMGIFGKFGAVFGSMPPSVLGGMQVFLYSTIVVAGVRVLGLVNFTRRNRFILTASLGIGFMDIVSPSWFSSVLAYSGSNVHLQGFEQGINLIVETPFIIAAVVGVVLNLALKDEVARIETNAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWN4</accession>
    <name>A0A317WWN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_41988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468508.1">
        <property type="nucleotide sequence ID" value="XM_025607397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWN4"/>
    <dbReference type="GeneID" id="37109540"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="168" mass="18843" checksum="781D8275C79596A8" modified="2018-10-10" version="1">MPMRIHCNSEEKQVTQDQVILILEIDWVLSRKTTDGSRSNTRSCKASFRPPSTGLQYHSEQSRQSHHLPAASLVSLAHDGSRRLLGNIPGATPKSHLPVHGYSRLNPGHWMKERSCASWMGKLSLSGKVCMSHMAAGFYARLFRINTVSVTAKRYFLQHTHLAFACKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWU8</accession>
    <name>A0A317WWU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_584909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468578.1">
        <property type="nucleotide sequence ID" value="XM_025615662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWU8"/>
    <dbReference type="GeneID" id="37117805"/>
    <dbReference type="OrthoDB" id="4355739at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY89667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="201" mass="22582" checksum="BFBD09004E9EF697" modified="2018-10-10" version="1">MPKFYFLSSDFDQNPELAITAKLGSLIIKTAGEEDHAYQIDELETLEFRPDSQFITRSVDASRQAQERLDNARQEDKAIFMVTGLKVATGFRLWAKVDSSTHPRITLPYLIWGRDVTSNLEISKTTGWTTQYGPVKNKVIFAMRVVKITRGDDGSYVSNDEDGGQFAKDSKQKGAAAGLEVAQVDEGMRDREFGAYSLWLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYB4</accession>
    <name>A0A317WYB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_533494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469091.1">
        <property type="nucleotide sequence ID" value="XM_025611346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYB4"/>
    <dbReference type="STRING" id="1450535.A0A317WYB4"/>
    <dbReference type="GeneID" id="37113489"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="127"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="238" mass="26959" checksum="5A7C9127D506C708" modified="2018-10-10" version="1">MGNIRQTRKKRSSLPTVKAKRTGLLKSGKKKINVLGNAIIAENWDRKLTLTQNYRRLGLVHRLNAPSGGSQKRATDDGVEGEPEDSLYIKSSAEALAKQTATSDIKVERDPETGKILRVIRSDDEVEVAGRKHKRSNPLNDPLNDLSDNEREAAQSRQKNTGTSIVQQLERQADQEGVAVRAKKPRHQSKREEEWILRLVERHGENYVAMARDRKLNPMQQSVGDLKRRIGKWQKSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYE1</accession>
    <name>A0A317WYE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxyphosphonoenolpyruvate mutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_574128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468730.1">
        <property type="nucleotide sequence ID" value="XM_025615004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYE1"/>
    <dbReference type="STRING" id="1450535.A0A317WYE1"/>
    <dbReference type="GeneID" id="37117147"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY90352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="300" mass="31434" checksum="052927B28C3FF76A" modified="2018-10-10" version="1">MVASPAVARLRQLLADESKIIVCPGVYDGFTARIALAEGFDALYMTGAGTTASRLGQPDLGVVTLNEMRGNAEMIAGLDPAVPLIADADTGFGGSLMVHRTVTEYIRAGVAALHLEDQPTSKRCGHLSNKQLVPEAEYLDRIRAAINARARSGGDIVLIARTDALQSLGYEAAVSRLKGAIALGADVAFLEGVASAEQARQVCEELKPTPVLFNAVPGGVSPDLSVQEAQELGFRLIIYPGLALGAVYQAVREAAQKLKETGTQAVRAGQGPRDIFNVLGLQEAVALDLAAGGRLYDKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ57</accession>
    <name>A0A317WZ57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_565182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469000.1">
        <property type="nucleotide sequence ID" value="XM_025614479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ57"/>
    <dbReference type="GeneID" id="37116622"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="76"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY90622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="400" mass="43750" checksum="89611064B25E915B" modified="2018-10-10" version="1">MGSLRLNIPSSSPALTFVRNRQRKSLYAGLASILLLVVWGTLLIISDAPYGGLGHGIGSSDRLGLAAIQNQTLGFEKIFCINLPSRTDKRDAIVLASSITQFRVDWIDGVSSEDMSPKAYPPRFDEPDRPRMLPGEIGSWRAHVNAIQRIISDRISTALILEDDVDWDITLKSQLHEFALGALALQTQSRPTHSPYGQTWDLLWLGHCGTKCQKSTPFYILPNDPTSVPVYALPPYWAGPAIHPLVDNIKHNRIICKSTMGVCSTAYAVTFTAAQKILAAVSVAPSEESMPAGEGIVFDVVLGRLCESGYLRCIAAYPSLMGNWKGEGLPSKGSDIQYRYDGPKEGRVYEGASFQGVVFSVMGNLGRLVAGEGVGRALVRDVMWEEVRVDWKGEMVLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZV3</accession>
    <name>A0A317WZV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_463346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468636.1">
        <property type="nucleotide sequence ID" value="XM_025608021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZV3"/>
    <dbReference type="GeneID" id="37110164"/>
    <dbReference type="OrthoDB" id="3880384at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY90258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="164" mass="19242" checksum="641708B43A3389CD" modified="2018-10-10" version="1">MAPNLFLCLRKVFCPTYWFQRGERIQGSIHKEEHWDSPVPGIYKYIPGRGWHLVYKDGNDADEKVPVPLVYCRILHRYVFEHEMEDRCRWHSVETSEGAKPEKFLFFLLDDGFTWVAGWDAKGKFIAGPYQKWHYDAEVGTMRRVLFPESSNVSRASVLPNKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X302</accession>
    <name>A0A317X302_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_488534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469605.1">
        <property type="nucleotide sequence ID" value="XM_025609068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X302"/>
    <dbReference type="STRING" id="1450535.A0A317X302"/>
    <dbReference type="GeneID" id="37111211"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="707"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="768"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="707"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="777"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY91877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="979" mass="108757" checksum="E5E0C55D04F6E34B" modified="2018-10-10" version="1">MAQHHAASKKRRREPFNVDTKLVEIYEDLASEKDDIRLKAAQLLVSQFTPDKNPADDQIKKVLQRLFRGLCSSRKAARIGFSIALTEVISQVFGSPRDSSELSISTVMNIWESQTNATGGESGQEQRDHHFGRLFGAEAIIKSSILFKAGVPFNEWTKLLDLVFELAKKKPWLREECGWIIYRCIFELAAQKAEAKFVESALDRLCSNELARTPEGVAIWLAAKDLFPDVQFPGKVWKHDDPLDVRERNQLAKVMKESSTAESESEGGKAKSSGVWNSKLHFAWDTVISRLGDAPVKETSKSKSSGRLSFVDFWTEVVDNGLFSSSSSEERKYWGFLLFNKVINESPLKLASLVFTKNLVRCLMNQLAVEDRYLHRMAVKAAKAIQTRVSKEPAFAAASVHGLMGPSGSVSFDQATKTKTVEKIVVEANLDALKQIVPLFVSLLASPGTTDSKAAASSRQVLAGLLLSIVRARASASEAEEGMQKVLEQILFAFVRLAYFKHNEGDENQSAVPPLTEQTQELFRSRINSCINSLIATEKYAGVPYAVVRKIRDAVESEEHGKFIINMDDAIQESVKGAFKSLKKLSNMEKGDKASIDAFKLLYSLTILQVYNGDADAASMLEELDFCYTKIFGDKKSKKEETSDASDALVEILLSFASKQSQLFRRMSEQVFGAFADSITENGLESLTSILEAKESLAGQQEMFDQQDDEGDEDMMDVDEEDSDVEVVEAAGSGDESDDDEAEEESDDDANDEEEALFEAKLAEALGTHRADKDLNEDSEGSDADMNDDEMEEIDTQLVKVFKARRDALGQKKDKKDAKENMVNFKNRVLDLLEIYVKKCHSKLLALDLLLPLLRLTRRSTVKQISNKASGVLREYTKHCKGTALPSLESTEPVWDLLKSIHTEATHSGPPAHASGCSQASLLVVKTLAAHDKQTIAGAVDVYAETRKAQLLSKKCHVQPSFFTDWNNWCVSSSKQMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X327</accession>
    <name>A0A317X327_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 8">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_487512</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 8"/>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469795.1">
        <property type="nucleotide sequence ID" value="XM_025609041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X327"/>
    <dbReference type="STRING" id="1450535.A0A317X327"/>
    <dbReference type="GeneID" id="37111184"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000005">
        <property type="entry name" value="Arabinan endo-1,5-alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016315433" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="10">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="320" mass="34387" checksum="3DB552EA29F527BE" modified="2018-10-10" version="1">MRFALAALAALPGLALAYSNPESCSGVCIVSDPGLMRRVSDGKYFRFSTGGEITFATSDSLFGPWTGVGSVLPDGSSIDLSGNTDLWAPDLHYIEGTYYCFYAVSTFGSQSSAIGLATSATMELDSWTDHGSIGVKSSSGKLYNAIDPNLIKADGTFYMNFGSFYDDIYQVEMNSAGTKSAGSAAYNLAFNATSTHSEEGSYMYQYGDYYYLFFSSGACCGYDTDRPAAGEEYKIMVCRSTKATGNFVDKDGVACTESGGSPVLESHGTVYGPGGQGVYDDPEYGTILYYHYINTEIGYADSDKQFGWNVISWSDGWPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3Q2</accession>
    <name>A0A317X3Q2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_513883</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NADP(+) = (2R)-3-phospho-glyceroyl phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; Calvin cycle.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469326.1">
        <property type="nucleotide sequence ID" value="XM_025609858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3Q2"/>
    <dbReference type="STRING" id="1450535.A0A317X3Q2"/>
    <dbReference type="GeneID" id="37112001"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000002">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF134">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="12">
        <location>
            <begin position="19"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="232"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="10">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY91598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="359" mass="39009" checksum="E946B1C11580020C" modified="2018-10-10" version="1">MAPSTNDSPVGITTSPFTCKVGINGFGRIGRNVLRASLLRSDIQVVAINHTCLTVDDLNYLIRYDSSMGALDETTSIQIISDNLITINDTPITLTSERDLENLKWDTLGVEYVLECTGKFTKQNLAMDHIVYGQAKRVLISAPSSDSPTFVYGVNSDVYRPTDDNRIISNASCTTNCVTPVLKVLNENFGIVQGFLTTVHAATRSQQVLDGYSQKNRRLGRGVFNNIIPTTTGAAKAIASVLPELSGKVTGVSIRVPTPNVSMIDLTISTEKPTSISEIISAFRIASKSSMAGVLRVTDEELVSTDYNGSPYSAIIDAPACAELNSQFFKIMAWYDNEWGYSNRLLDLAVHVHAVQNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3T0</accession>
    <name>A0A317X3T0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="12">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_532993</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470030.1">
        <property type="nucleotide sequence ID" value="XM_025611248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3T0"/>
    <dbReference type="STRING" id="1450535.A0A317X3T0"/>
    <dbReference type="GeneID" id="37113391"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="120"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="362"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="592"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="600"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY93269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="632" mass="71185" checksum="7BB5ECABA520826A" modified="2018-10-10" version="1">MPVSKAKSSPSVKRRDRLTLAKLASYDDVATDALVDRAYFWTNTRKNRTKYNPARGIKDDEVASILLHDVIVGKDAARAETKLLNMPGLKKYLAKLPTDREKDWFRRHLRKYIQMYLPDSPFEVTTTNRYMVTEHEAAICARKFIKQGQEIKYLSGTLVPMTREEEQDLDLKRKDFSIVMSSRRKTPSFFLGPARFANHDCNANGRLVTRGMEGMQVVAIRNIHIGEEITVSYGDDYFGIDNCECLCLTCERAVRNGWAPQLDSDEESPASTPALTDEAALSPQKRKYAPDSDSESSPASTPRKRTKFTRQNSKLRSEVVFSDITPSIESVTEQPAAAEFCPPALSVPHATVAETVNDHVIDNKSDINADSTVQSTTATDPESPGSLEADDSHRSSTSTAATSVCDNTVQIKVEEAPEASVRASTLAVEGHLDLSVTGPAERERRILGADNDALSDLSDSLELDEKLGTVVKKSRKSRSKEVVPSVEVEPPRARVPGDYTKTSRLLAQAYDRWVDCRTCTVWFVQQDSYLTRRECPRCERHSKLYGFQWPKTDREGPMDDEERVMDHRMVHRFLYPEEEALVSRKDRGVSFGITPTPELSEPRAETEETDAGEDRRNTRASRRRTRSLRMTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X422</accession>
    <name>A0A317X422_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_512044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469856.1">
        <property type="nucleotide sequence ID" value="XM_025609793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X422"/>
    <dbReference type="STRING" id="1450535.A0A317X422"/>
    <dbReference type="GeneID" id="37111936"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016427488" evidence="1">
        <location>
            <begin position="22"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="404"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="749"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="849" mass="91447" checksum="0BB126C5608E8DD8" modified="2018-10-10" version="1">MSARQLAIFTCSSLLLSLTGASDITVLPTKYKADSSFANYTSHGNAACFTLDQNRPLITLDYGTEVGGFPFFDVESLSSAVQIEAKYTETEPGLEAPFGDGPWTFTNGLSNTFRVETFNVTSTGKVESFFIQGGLRWQNLLLLTEGSVRICQAGIRSGNDRTPVNELPGFFESSNNLYNEIWALGPRTVQQACIASNTAPSTWEVTSDGVYLRGQQPAQSVIGASFANYTMDFHTKIVRGGTGWKVAAGVGGFGPYFVLASEYPSGSTFVNINRTIVPPNTLAVGYGWNLVNQTSLTTGKVNHYPLPFDIKEGHWYGISTTINATGYGVTVNGTDIFVAFNDLQIVSGSTGSSGSLTGGTWGFGPYQDQIALVKDVEVHAQNGTLIYNNPMTSSSVLEEFGVMTSNHSICLDGAKRDRLVWSGDFVHTYRVIQSSTGRSDFVTGSLKYWLDRQALDSSEYRGYFSMSPAMGQSAKYVNTYDSFGLLDYQLFFLDAFAGYYRNSGDNNFVLQHWKQIKKGVEAVLSLIDEQSGLAVATDIGAFFSGSSNGTAVSALLAHTLSRVAEIASVVDETDVASRWTRSADSIKDAIRDQLWNSHLGAYAADLSDLTEQSITGTAWAILSGVSNSTQAESSIATLSSLRLGIGYKTSTSVSNASTTDLAPFLSGFLLEAILQASRNSPSASQARVTAISVLLDQLWAAMVTQDEYYTGGAWEYVYPDGRPGLDLYTSHAHPWAAAPTYVLTEYVLGIQATSAGFSEWAFRPAILDVNVSWARGRVPTPNGPIRASWQLGHNDTVQLNVCGPNNTTGIVSLPFAVESYTVNGETTAGDNFGVRVSGGSCADVQIVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4C1</accession>
    <name>A0A317X4C1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDSL lipase/acylhydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_544235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469956.1">
        <property type="nucleotide sequence ID" value="XM_025613171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4C1"/>
    <dbReference type="STRING" id="1450535.A0A317X4C1"/>
    <dbReference type="GeneID" id="37115314"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="262" mass="29421" checksum="05159DAD518C83B1" modified="2018-10-10" version="1">MSNTAPPADDEAVYKPYDQFLLFGDSITEYSSGQDMGFGFHPALQNAYSRRLDVVNRGLAGYNSLHAIKVFPRCFPPTEQANVRLMHQTIWFGANDASLPSFEQHVPIETYKANLKRIIQHPLTVAQKPRIMIITPPPINEYQLAGFDAMKGNPHPTRTAAHTKQYVEAAREVAAEFGLPVADVWSAFMSSVGWKEGQPLVGSRDLPYDDKFATLFTDGLHLAANGYRIVFEEVIKTIRENWPDQLPENLPYVFPAWSLAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4R6</accession>
    <name>A0A317X4R6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ornithine decarboxylase</fullName>
            <ecNumber evidence="10">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_347222</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="10"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470360.1">
        <property type="nucleotide sequence ID" value="XM_025607081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4R6"/>
    <dbReference type="STRING" id="1450535.A0A317X4R6"/>
    <dbReference type="GeneID" id="37109224"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6 15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="17">
        <location>
            <begin position="77"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="18">
        <location>
            <begin position="83"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="15">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY93599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="452" mass="50070" checksum="17A854FA4987ECD8" modified="2018-10-10" version="1">MVMAPTACVPAEVCTPKFYSEKHDYNLNWDHGQFSNNGGDDISQSRLAAKELVLDILKKRAAEVNVDCCAPGAEDPFYVADMGEIYRQHLRWKMNLSRVRPFYAVKCNPDPEILRLMAKLGNGFDCASKAEIDLALETGIDPSRIIYAQPCKTKSYLRYAAQVGVKQMTFDNADELYKIKANYPEAELYLRILTDDSNSMCQFSMKFGASMDVARQLLELAYQLELKVVGVSFHVGSGAEDPKAFLKAVQDARLVFDQAAEIGHELHTLDVGGGFSQDTFEKFACVLSEALDTYFPPNIRVIAEPGRYYVASAFTLAANVIARRDVRDPEDPTNDAYMLYLNDGVYGNFSNIIFDHQHPVAQVLTCASAANSPYAATSGGITYSIWGPTCDGIDVISKRIQLPALLAVGDWLYFEEMGAYTKCSATRFNGFSDNHEVIYISSEAGASALLEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X573</accession>
    <name>A0A317X573_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_622103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470507.1">
        <property type="nucleotide sequence ID" value="XM_025617043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X573"/>
    <dbReference type="GeneID" id="37119186"/>
    <dbReference type="OrthoDB" id="5304367at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="77" mass="8190" checksum="C18DD333083FCC6C" modified="2018-10-10" version="1">MAGKTLGRSSGSLNAPIAAFTMALLLGSYCISSIHTARREAQSASSTTTTPRAKRTESQSSWVQQALEESREEKGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5A0</accession>
    <name>A0A317X5A0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Intermembrane space AAA protease IAP-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_341152</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470142.1">
        <property type="nucleotide sequence ID" value="XM_025607036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5A0"/>
    <dbReference type="STRING" id="1450535.A0A317X5A0"/>
    <dbReference type="GeneID" id="37109179"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="347"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="743"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="767"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY93381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="784" mass="85455" checksum="9B9EEF7649741A1B" modified="2018-10-10" version="1">MSKLLNAPRNNVEYTRPGYAAPPPSQRAVAEATSTGVSAVSLPEYLSSVSSEALKASIFGKPVQSGWARSLFNEPTMWTTPSLATRHLASPTARSYSTLSMSLNRLRFAPKVEGLSRLQQQRFLFGGPSQNLLAQKEKTANNNASSANAQNAFYQALLRANLPAIVVERYRSGHFATNATTDEIYMKALQRVGGADPAVAVSASGQAVSPERLQAIGQAVATQFHGGQFGSSTQYGSAVKQTGTGGKEDPLHVVVEESTGSAVFRWVKFLFYFAFFAYLSLVMITILVETTGALKNIRGPQNSEAQPQQQTVRFSDVHGCDEAKEELQELVEFLTNPDRFSSLGGKLPKGVLLVGPPGTGKTLLARAVAGEAGVPFFYMSGSEFDEVYVGVGAKRVRELFTQARSKSPAIIFIDELDAIGAKRNERDAAYVKQTLNQLLTELDGFSQSSGVIIIAATNYPQLLDKALTRPGRFDRKVTVGLPDVRGRMDILRHHMKEVQISMDVDVGVIARGTPGFSGADLENLVNQAAIYASRNKSTKVGPKDFDWAKDKIMMGAEARSRIIQDKDKLLTAYHEAGHALVAYFSPSSTPLYKITIVPRGMALGVTHFLPEMDMVSRNYTEYLSDIDVSMGGKAAEELVFGPDKVTSGISADIQQATETAFTLITRFGYSKKLGNVDLSTNYDSLSSETKQEIESEVRRLVEEGRVRATNILTEKRDELETLTKALIEYETLTKEEMEKVLRGEKLDKLEPVPPAAPPPLKLPEALQTTRLTPPSVSSGRSVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X656</accession>
    <name>A0A317X656_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_511434</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470422.1">
        <property type="nucleotide sequence ID" value="XM_025609769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X656"/>
    <dbReference type="STRING" id="1450535.A0A317X656"/>
    <dbReference type="GeneID" id="37111912"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="203" mass="22689" checksum="0A002B6936C06254" modified="2018-10-10" version="1">MEVLLGITGKDFVILAASKAAMRGPTILKAEDDKTKQLNKHSLMAFSGEAGDTVQFAEYIQANIQLYTMRNDTELGPNAVASFVRGEMARSLRSRNPYTVNLLLGGVDPITEKPHLYWIDYLASLAPVPYAAHGYAQYYCLSTLDKHHHPDITLEEGMKLLEMCTDELKRRLPIDYKGVLVKVVTKDGVQEVEFDNNRIVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6T0</accession>
    <name>A0A317X6T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF788 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_532983</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470018.1">
        <property type="nucleotide sequence ID" value="XM_025611243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6T0"/>
    <dbReference type="STRING" id="1450535.A0A317X6T0"/>
    <dbReference type="GeneID" id="37113386"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="173" mass="19201" checksum="5C8078E5EF4ADBBA" modified="2018-10-10" version="1">MAQKAAKTLAARNASLLLRTHVISAALHALFLVLHWLFNRPRSLTPYLVLACPTLLIEFYLDRLGRPSYATPDGSLRSPGEDLGAAGLTEYMWDVLYWTWGCIGAVCVFGDRAWWLWTVVPVYSVWLAYSTFTGMKNGLAGMGGGGGGQEQVATESKRQKKMEKRGGQRAQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6U3</accession>
    <name>A0A317X6U3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_327024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471050.1">
        <property type="nucleotide sequence ID" value="XM_025606948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6U3"/>
    <dbReference type="STRING" id="1450535.A0A317X6U3"/>
    <dbReference type="GeneID" id="37109091"/>
    <dbReference type="OrthoDB" id="5378435at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="396" mass="43426" checksum="035530AF4FA0C4F3" modified="2018-10-10" version="1">MADCWQPQPAFANPSWVQGNQSCWRTSTFRDLIQAFPRPKHTGRVTKPRSAGNSPSSAGRRRTATIPYSSPMYQGYQAPVNPALVASALARTSRTRPTSWHPALESVNYSTAQYLPATTALDNFAALGVCPQPLPTASATYEDTSMLPSYAPLDMGLHALPGGQQQMPLQQSSFLQMNESQSELVSWDTNGSTLPTMAEPMSDCWSFDMSSMHNNIPSTYVTASGYESAPSSGYLTGPSTPDFLPIQRPDDDLNSQIGSLSEKPKAEDELVGMGLYSNPEASLETSLLGLSGKGLKLEETFTPSSDNEAEDRDDNDNEDDDDDQSEEDEVDHNGPDSNQKQPEQKTFQQPVKAPGSMMQRSFFFEDDELEQHAVVEPQPFVNMASQPCMSYGYGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6W7</accession>
    <name>A0A317X6W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_554806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470058.1">
        <property type="nucleotide sequence ID" value="XM_025613742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6W7"/>
    <dbReference type="STRING" id="1450535.A0A317X6W7"/>
    <dbReference type="GeneID" id="37115885"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016366485" evidence="7">
        <location>
            <begin position="25"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="27"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="152"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="152"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY93297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="421" mass="47743" checksum="EE88134DB56AB7BF" modified="2018-10-10" version="1">MFSTMRTICFFFVLTLCLVQLVLAAEDYYKILEVDKSASEKDIKRAYRNLSKKYHPDKNPGDESAQKKFVEIAEAYDVLSTPSTRKIYDQYGHEGVEQHRQGGSAGRQAHDPFDLFSRFFGGGGHFGHAPGHRRGPDMELRVGLPLKDFYTGREFSFTVEKQQICDACEGTGSADREVVTCDKCAGRGMVIQKHQLAPGMFQQVQMHCDKCGGQGKMIKKPCPICHGHRVVRNEVETSATVEPGMDKGMRIVFENEADESPDYIAGDLVLILEEKEPEMGTTDEYRNDGAFFRRKGKDLFWKEALSLREAWMGEWTRNITHLDGHVVHLGRKRGEVVQPLSVETVQGEGMPYYSDGHLHDHEEDEEPGNLYVEYTVILPDQMESGMEKDFLGLWEKWRKKNGVDLAHDSGRPMPAPVKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6X1</accession>
    <name>A0A317X6X1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_485439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470672.1">
        <property type="nucleotide sequence ID" value="XM_025608980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6X1"/>
    <dbReference type="STRING" id="1450535.A0A317X6X1"/>
    <dbReference type="GeneID" id="37111123"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="183"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="738"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="780"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="822"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="864"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="906"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="948"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY93911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1085" mass="120699" checksum="1215457DAB9D67B2" modified="2018-10-10" version="1">MDGLSSAASVIAVIQLTGSLVELCGGYIKQVKHARDEILTLQRAIVGLQGTLQDLQNLVQTNNGNTLPTSSRLVGNITDCLSDLRGLETRLDPGKRKKLMRKVGWRALKWPLKRTEVEEVIQNLERYKTSFLLSLQVDQSSLMVGRAQDMDFEKLEGVMEAAFESFSDRDEVQCLQGTRTVLLQQIMDWALLPSRKSIFWLKGMAGTGKSTISRTVAESLKNINHLGASFFFKRGEGDRGNAKKFFPTLIRQLMLRIPGLRSGVQMVLHDNPDIASKSLREQFEKLLLQPLVTLDQLGRQPQTAVIVIDALDECEHDQDIRAIIRLLPSLQKANGVSIRIFVTSRPELPIHLGFSEITGHEYQDLALHEIPEEVTALDIHLFLQDRFVKIKRDKNISEDWPGDEVIQKLVEMSAPLFISAATVCRYIESSKMEPKLRLAELLKDQAKYVSRMDKTYLPILTRLLDDQESDEFEEQQLLQEFQAIVGVIILLAVPLSINALSLFLGIGADQISNRLDTFRSVLSIPSSRDQPVRILHLSFRDFLVQSRTKFLVGAPKKHKDIAKCCLKTMQSHLQKDICNLESPGTRRADINPQDIRQYLPPELQYSCRYWIHHLNESQVSSSEIEDVRVFLQKHFLHWVEAMCLLGLISEVVGMLDLLHTDILGNNDSLLADFLHDAKRFVLKNCQVADEAPLQIYCAGLVFAPQTALIRSDFSEDLPSWICQLPKVNEKWGAELQTLEGHSDSVWSVAFSPDGRLLASSSIDKTVRLWDPVTGVLQQTLEGHSDSVRSVAFSPDGRLLASGSIDKTVRLWDPVTGVLQQTLEGHSDSVRSVAFSPDGRLLASGSGDKTVRLWDPVTGILQQTLEGHSSWVRSVAFSPDGRLLASGSGDKTVRLWDPVTGVLQQTLEGHSDLVWSVAFSPDGRLLASGSIDKTVRLWDSVTGVLQQTLEDHSSWVQSVAFSPNGRLLASGSSDKTVRLWDPATGSLQQTLIIKGTVTELQFSQDGSYISTNLGSLNIQSRCGHNLSSSPKVHSDILINGPDWISVNGREVLWLPPEARPSCSAIKANTLALGHASGRVSFIGFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7A2</accession>
    <name>A0A317X7A2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sterol-binding-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_531470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471257.1">
        <property type="nucleotide sequence ID" value="XM_025610903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7A2"/>
    <dbReference type="STRING" id="1450535.A0A317X7A2"/>
    <dbReference type="GeneID" id="37113046"/>
    <dbReference type="OrthoDB" id="10265837at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1050.10:FF:000001">
        <property type="entry name" value="Putative Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003033">
        <property type="entry name" value="SCP2_sterol-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094:SF25">
        <property type="entry name" value="SCP2 STEROL-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10094">
        <property type="entry name" value="STEROL CARRIER PROTEIN 2 SCP-2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02036">
        <property type="entry name" value="SCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="127" mass="13525" checksum="41D28BBEC617FBB3" modified="2018-10-10" version="1">MSLKNDAFPSSAAFDAINATLQADATERKDAIDKAKAVIAFNIKNAQNKEESWYLDLKEKGVVGQGAPPGKADVTLSLSDADFSALVSGKANAQRLFMGGKLKIKGNIMKATKMEPVLKKAQAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7K0</accession>
    <name>A0A317X7K0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_278648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471345.1">
        <property type="nucleotide sequence ID" value="XM_025606611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7K0"/>
    <dbReference type="STRING" id="1450535.A0A317X7K0"/>
    <dbReference type="GeneID" id="37108754"/>
    <dbReference type="OrthoDB" id="4509259at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="352" mass="36145" checksum="D4A208052B9D2964" modified="2018-10-10" version="1">MPKMEDEQAPAIEKDATADKVEVPSGTTVQPQVVPGLGADASDEVTKDLEVPGLASADNDANKVAGATSSTAPQSTEAATEKVVEVPSTTREAKAAETSAADTTAAAPEEVSAKPQTAEAIAPSGALTSDVAESTSDVKQTTDEVTQAESATATKAPTAAADSKPVAVVPTSLTSPSATDKDANKTVEKSAVNPASEVEQPVKATEDKLQPAKEQAPEKRQSVVPSTITDTKPQETEPQATPAVSEAPKEEGAAVKKAEEAKPSETKPSEPQSEGPSVARTAEESKPEAAQAGQQAAKPEEGKTAVEQAKDTAKGEANKAQETAKSEVSSKAEKRKSGLFAWIKRKVKGDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7U0</accession>
    <name>A0A317X7U0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_622184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469719.1">
        <property type="nucleotide sequence ID" value="XM_025617052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7U0"/>
    <dbReference type="GeneID" id="37119195"/>
    <dbReference type="OrthoDB" id="2935237at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY92958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="187" mass="21825" checksum="C0E9A44D5692570E" modified="2018-10-10" version="1">MTDPLPSILTQESWFWDPFHSNEIKFHPDGTGDLLCRYETQTWIMAQFTWTLSQQTTNTSTTQLTLPTTFPITLTLTKCLIPGSHIPPHIRINEALLTDEAFRPKTYTVRLDKGTFITQHDVTYATRKYDAARYFHRLVFDKSPYPPPEEWKEMSASLEAFRVWEWTEFCSRKVDRQLGVVGEMWGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8H6</accession>
    <name>A0A317X8H6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_315576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470723.1">
        <property type="nucleotide sequence ID" value="XM_025606854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8H6"/>
    <dbReference type="GeneID" id="37108997"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="55"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="343" mass="37172" checksum="6E4B4AC55E182243" modified="2018-10-10" version="1">MSNSALIFKQIPTGYFVPGQDVTVEPVSYDGNAPAPENGIFVQSVYASFDPYLRGRMRPAHIKSYSPAFALDAPIENAVIAKVLRSNVAAYKEGDLIIGYLPIQQYISVSAEQLVRVRALANPLGIEDVRVFLGALGMPGLTAYSSLYEIGKPKKGETIFVSAASGAVGQLVGQLAKHEGLKVIGSVGSDEKLEFITKELGFDGGFNYKTEKPGDALARLAPQGIDIYYENVGGEHLEAALNAMNDFGRIVVCGMISQYNGSGYPIKNITYVLTKRLDMRGFIVGDKGMGDKYTQEHQERVQKLIKEGSFKSLIHETEGIENAPEGLLGIFHGKNLGKAVLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8R5</accession>
    <name>A0A317X8R5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SWIB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_530848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471710.1">
        <property type="nucleotide sequence ID" value="XM_025610767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8R5"/>
    <dbReference type="STRING" id="1450535.A0A317X8R5"/>
    <dbReference type="GeneID" id="37112910"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="5"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="203"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="284" mass="31764" checksum="76711F3370779F8C" modified="2018-10-10" version="1">MSLSPDAHDRYIPIIDSILAKSDLTTISIKRIRKGLEDEIGYDLTPQKVAIRQLITERFDIVAYRGGEEATPETTATTSTTNGHGQDHDSVTPVEPLSPAQSSMSQKRQADSEEHSDTSNKTPPAKKQKPDNDIDADAQFAARLQAEENMRARQTRGASTRRSQPVKKKQPTKAKTSKKVKAEDDSDLESGSESGKKVNRSGGFHKPLTLSPALSALLDGEVTLSRPQTVKRLWQYIHEHDLQDPSDRRQIRCDDAMRAVFKQDRIHMFTMTKILSQNLYSPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X959</accession>
    <name>A0A317X959_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_288175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471636.1">
        <property type="nucleotide sequence ID" value="XM_025606684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X959"/>
    <dbReference type="STRING" id="1450535.A0A317X959"/>
    <dbReference type="GeneID" id="37108827"/>
    <dbReference type="OrthoDB" id="26242at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="80"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="560"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1039" mass="115436" checksum="18AB325C0272C844" modified="2018-10-10" version="1">MADVDVASYYNLPSAFPEEWPAELDESDHSEDEVLERRGSRSERSRYFALERSNSTRKGVTLGSFKGSNGRENLVKMDEPDPLGSGDSVLKILKTRGLSLDEESRLRNRFLLSSTSFSPALFLSQVHSDASIRSLLDGLNILSQSIDQKSASLKVLVEANFERFVRAKATIDSVYTEMRNQGKKEEFLSPQANRRSVGHFRNLSGSKHSISTSAIADAGPGKNALTKESEYGMKGIRVPLLEASVKAEELWGPALGGREREQVLKSVVDTMEKHRDIYEIGGLLSKSIKQRDFDSVFEQYGRARALSKTARDIADTATNQRRPLTDEEAHVILAMGRMWMDVDSQIQTFKRDLWRRLSDAPTTSTTVTATGPVEEHMELIGALLEIGVENNPIWVWLLSRYDFLKKKITAFCERCKTEIEILRRRLASGEKPTPQAVASYLWLAPRDGSLDTQTLRDTDQVIELWECISTYLSRLLSSQGGLLGEVFDFWEVAQSFIDGSRQKLLPAGFEGESRKHHRLSSSNARDLQKGAIELVNLIRESVLSLFADAPVDDVSLLTSPISTASPSSPGSRGVTPTESRFKLDPKNMPFPTPKRGEHWEDYAFWPPFSNSLSGVHYLGQCLVLIGTAASEMAALEPVLNSPNTHDLLKSLVSVARERSVRVACAAWGKDAEICKMLEDWTRDPEKRDLTKMPGLFVAFENAIISGMQKILYISEAMARSGSVDVVTQPPAKLLQMVRTQFVSSVYKALSGLVENAEHPTSSEDEDEWITAGSIVTRSQFDTSPSLLIADAVDARNRNVRILLTLSNIKAFQADLVPQLVANFENSFSVRLTEEAKTVRDVLNQIDDRLFQSYTKPTISALNSTIANSITAPEWEPTTARPDQVRPYVYTTMLDLVLVHTEITTTIPSTLSTTATRSPSAAQSPLLSVVLTYLLTQVSTSLLAAFSSRSSYTLAALMQATLDTEFIAQTMSQFSTDEASAIQSQIYVELDRRTTHEARARLQSELGEMRGILKRLREKTKGEFACFRKPRSGAGHKPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9I8</accession>
    <name>A0A317X9I8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_621946</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470329.1">
        <property type="nucleotide sequence ID" value="XM_025617032.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37119175"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="306"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="898"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="819"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1299" mass="146659" checksum="58EF6FBD66FD030C" modified="2018-10-10" version="1">MAFDTHSLANSLPFGRTITRELTGAVEGTVNEALRLTNVTLNAPDEHKVHAFLISLLKCTTLPEFVDDINDPSDALTEANRAGDNVDWAAIPSDGLTRPLRMFDIDTQNMVDTTQLTSADQYCVLSHSWKGAEINYTYFTSATKENDAIASLAVLDGEEGEQQQQEIADVGLLERRCFADLVAAIERLGGQELAEEHLADHLRKKTQQRKFTEAMNEEEKTRRDFKTKEQQQEHAERILRGMGCDPEKSDLSQWSTKAKAAWHNADKTRDEKLRQGTPSLSGNRSIFYARETLLECLQRRKSLRKLKQAIKHTKYLFEERPFLPAEGKRYVWLDTCCINKADGDELSKSLALMGEWYTNADFCLVHLDESFSDQEWRDELIAHGRGKSVTEIPEVIEPESKTKDKANQINSKEDKLIPAKLIRHFWDIIKADIPWATRGWTLQELVLSKMTFYVNPDWELLDRGIDQLGSYYYVTPFMEHYLNNITPVSPDFATEFYRLWHCNGDDEDNGEVVDDEDGDVRTAADNARDTVKFRKLAAALESVGFTVPKFLSSQSATAQIEWAVDTCATKLCSDNPDINSIEEVMQLLEDPKEHREKGSGNGFNESSDEDPRINGLYRPFLRLLLEKLRDSALTAIRQDLVTISKFGKISELHDWTLGAGPANFSAFSVLTTSASRNTTVATDKAYCLMGILNVKFPAFPAEGLSKALSRLFDEVVIASSDVSVFNWSGKYYGSTIQGRSLYPSRIEAYQDRANSGNATNDVNKKLLDIFSAKQNETMKVAWEVESLLIQMLKLVKPLNHENVPQKLLNDLDGVIETLKTKSLNNLEEDRKTLRDLKKQISECSDLFEQESSKAEATPDSSRSNHVEDAEKGSTFFMPSVSIPTLEIKSPLHIPRTFSRPWGEKKPPMAVLPTPPEEPDRVTEIFTNLAKSMEKGFEALRGFPSQDDDEEDEERDAAAFLDPDAQHDDAPLDVIDRRTRCNNPIVVSSSGISGTFDVQRVVVTMIDPEALRAQIRRAVSGQKIEGWCRVSTGFAYTLVNFSCDRDMLQQQLDMTEVNEKCLLSVSEATTPGPEGSTSMFARQRLRKMIDMVQEPNLHAVAGEWVLARFSDVPTADWFLSRLELGAGRGFYARRIATDAFTFANAIPEQGLNDYWHQFMTDKKEIACKALHNYLQGKRIRRNTGDFFHNLQSNAEVPIIDSLTLIIEKMAEGVVWVGDFALRAVADHMRHHITRSAMERIPPKVQAAVQDLNARKGLFPTIDDRRNRAFKNPYNAILISTLKDARSRNMVYSVSVKICHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9M4</accession>
    <name>A0A317X9M4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Immune-responsive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_531208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472047.1">
        <property type="nucleotide sequence ID" value="XM_025610850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9M4"/>
    <dbReference type="STRING" id="1450535.A0A317X9M4"/>
    <dbReference type="GeneID" id="37112993"/>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="17"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="289"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="481" mass="52581" checksum="306D9BBCAF41C2A7" modified="2018-10-10" version="1">MTAHTAPATSATSATRTLATWLEDLSPATIPEEIRTRAKYLMLDGLGCALLGSRLPWSVKAHDTITAIEGTGKCTVIGWNETLPPNAAALLNSTFLQGFDLDDVHIEAPIHASSVILPAVLAAAQQEHPTQRITGPDFLTAMVAGYEVGPRVGYALGGSHMLTIGWHSGAIFGPAASAAAVSKLLGLPADQIEDALGMACTQACGLMSAQFESMVKRMQHGFAARSGVLASYLARQGFMGIKEIFDRSYGGFLQMFTLGAEKEPRYFPEEVCKNLGETWQMEKIRQKPYALMAGTHCTVDCIRELQRLYPERMAKWDTMVRIEAEMARAAMKKGGWAPQKPATVTAAQMCVPYAVALQVVDGEIVPGQFAPGKLNREELWEVIGKVECREVDEFDYSWAQRVRITFEDGEVVETMLKAPRGVNPELSNEEVVEKWRAVTRGVIGEERQREIEAVVLNMEEVDDVVGRLGELLGPETVNVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAT2</accession>
    <name>A0A317XAT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="12">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_281168</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471438.1">
        <property type="nucleotide sequence ID" value="XM_025606626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAT2"/>
    <dbReference type="STRING" id="1450535.A0A317XAT2"/>
    <dbReference type="GeneID" id="37108769"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17941">
        <property type="entry name" value="DEADc_DDX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="79"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="279"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="495"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="671"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="48"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="671"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY94677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="807" mass="91096" checksum="B23C317CA460423D" modified="2018-10-10" version="1">MAPINGSRNGKPSKAPQRAGNLKRKRVQDDLSTLVQKVEELDVKEAVKQFSDLPLSESTASGLSSSHYKTLTDIQSRAISHALKGRDILGAAKTGSGKTLAFLIPILENLYRKQWSEHDGLGALVLSPTRELAIQIFEVLRKIGRYHTFSAGLVIGGKSLREEQDRLGRMNILVCTPGRMLQHLDQTSFFETNNLQMLVLDEADRILDMGFQKTVDAIIGHLPQERQTLLFSATQTKKVSDLARLSLQDPQYVAVHESASSATPSKLQQHYVVTPLAQKLDVLWSFIRSNLKSKTIVFLSSGKQVRFVYESFRHMQPGIPLMHLHGRQKQGGRLDITTKFSQAQHAVLFATDVAARGLDFPAVDWVIQLDCPEDADTYIHRVGRTARYERDGRAVLFLDPSEEKGMLKRLEQKKVQVERINIKANKQQSVKDQLQNMCFKDPELKYLGQKAFISYAKSVYVQKDKEIFNIKELKLDDFAASLGLPGAPRIKFIKGDDTKERKNASRATAHASSDDESDEEGGEKKAKKEEPQVRTKYDRMFERRNQDVLADHYHKLINDDGTMVESIQATEDADEDDDFLSVKRRYEAGDKDLDVGGSSSEDEDEGKKDGSKKTKVVQLDGKEALVIDSKRREKLLKSKKKLLKFKGKGTKLVYDDEGNAHEIYEMEDEEQFKAKGDAKEQQARFLAEETERTRQADVEDKEVAKQKKREKKEKRKARERELLAMEEEGGDLVQLPSYQDEDRDMDGGFSASEAEEEAPRPNKKARVSFADKSSEEEPRPKKAKKSQAPEQIQTLEDLESLAAGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAZ6</accession>
    <name>A0A317XAZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_136101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472537.1">
        <property type="nucleotide sequence ID" value="XM_025605695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAZ6"/>
    <dbReference type="GeneID" id="37107838"/>
    <dbReference type="OrthoDB" id="4349176at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="274" mass="30618" checksum="E81E0FEB68EAB940" modified="2018-10-10" version="1">MDLSSLEGPPIPDPRFTVPSRRSNVPSIQLDMSTPLSPVSPLTPPPYDLPPRPSSTDTFFRPRPQYTYRSLEPQPEPTRSQRCHSLLPPTPTGEHVNQQQPTPNPTLNLPPPPPSSSFSLHPWSPRSRSVSDTTPHQSPSPMLSTTTTTTVTTTQAVTTTTTTQGNRLIWLESEKLWFLKPLPSESSPFLTEDHGAGTRPTPNTRYTPYSPSAVRTDYRFASTTDTYDIPPPYERHIYDRPLPPLPTEDRQTGELYGSRWTAVARRRANRSALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB01</accession>
    <name>A0A317XB01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Secretory pathway Sec39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_507019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472534.1">
        <property type="nucleotide sequence ID" value="XM_025609597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB01"/>
    <dbReference type="GeneID" id="37111740"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013244">
        <property type="entry name" value="Sec39_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787:SF3">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40787">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08314">
        <property type="entry name" value="Sec39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016285149" evidence="6">
        <location>
            <begin position="28"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Sec39" evidence="7">
        <location>
            <begin position="13"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="874"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="888"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY95773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="938" mass="103668" checksum="A17549AA3B9B2BC5" modified="2018-10-10" version="1">MAVLQGLSGAHAILLATHLCATGDVVALPLLQAQFPAHLPLERLLRIILTFLPESADPSTYTPVLQALVDGRQLETDGDGINNAFVKDLPEPIVRKRVREIRLLPLQHPDDQDTQDPADLLTQFLIHRAHRIDSETALQPLVLDLLLPFYHRSEALRTWLISSLLPLLRLNYEYYPSQDETFSLDILESMDNSIAVNVLLSMTGATKSNMDLVRNLRGLVGAWMHGSNRSKRRRLNEAAQENSITLPQDEAQSKTTAGIGWQQVNEWLLARSLVDHESAVNAFVNWDGPEDVDLGGYAEENKGLSHDELQDLRTRYGQTGLAVVYANADPSSPALEGSIRVLARIAELLKLEENLFLSPDISELPKVKFDPEPMSSTSRVSFLQNALLVASNPLTRPSASSISFLSAICLSLRILNELGHPTPCKTAANICLLNNEETQLHELRSVITSVVRQAKAGRDWSKTRQQLLWLRDWQGDHTEDSADDHVRHGLFWRVPRNIVEAEILKALLEVREYNLAVNIYMGSGSTLSSTLVEEAVKEAIFTAYDNASNGNRSRGGMKRAYDILQAFQPHFPDSASFKQIRALISATHALSFYSLTLQHGVPFQPVSIRVHPDPLSLIEKVLDQNPKSYTKLDDLLAIGRNLVSAGVSSRLTDEHDSPFLPPPSQEDATITAERRIMSLAISSALSCHDFGTAYSYILTRLTPPSLLPTSSPLTNPTPPKDDITWRAVYNAGRYRAPATTATPSNQTQISHLSQRMELLSLALVLAPSPEPLPEILGAWRRCDEELAALRARESEEEDLWDAKADNLTSTTLPGGFGPTDSERDAFETQQHQARRARAHASQNRLNHEEAPMGLFEVARGAALALQKNAFPLRSAPTTTKTIPDDHSVPSSHMRSDSALSDDQNGEGRVRKRDVVSNMVTDGLVSGLGWVLGAQPVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB22</accession>
    <name>A0A317XB22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_571240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472450.1">
        <property type="nucleotide sequence ID" value="XM_025614863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB22"/>
    <dbReference type="GeneID" id="37117006"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="175" mass="18825" checksum="0E9F5BE8D55738EB" modified="2018-10-10" version="1">MQPYPLITCGMGVNYTRLGYPGIRQHDKNSVSGPSGEDAVDGDVLQYLLWGTTTKYDLEGLQKKTGQLSAGVQLAVPDRGEDLPLSSRPVHTPEASRGFEALCQRQRQAETVQGNPSHESCPWQGYPGSTGGYFVLSDGVPPKASLPRLHGNHRGGVSRTSHPGWLIFPSSSSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBJ1</accession>
    <name>A0A317XBJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_459022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470681.1">
        <property type="nucleotide sequence ID" value="XM_025607821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBJ1"/>
    <dbReference type="STRING" id="1450535.A0A317XBJ1"/>
    <dbReference type="GeneID" id="37109964"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000024">
        <property type="entry name" value="MIP aquaporin (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="36147" checksum="D20FD242D7CB67BD" modified="2018-10-10" version="1">MKPQEWFRKRSANGQTVPMYNSSHSQLPMLHLPDTVRNNFIAVVGEFVGTFLFLFFSFAGTQVSNTPKPAEGADPNTQNLLYSALCFGFSLMVNVWAFYRVTGGLFNPSVTLALCLVGGLTPLRGVLVFAAQIVAGIASAGVVSALFPGALNVGTRLGGGASISQGLFIEVFLTAQLVFIIIMLAVVKHKSTFLAPVGIGLVFFVTEMVGDYYTGGSLNPARSLGPDVINRSFPGYHWIYWVGPLLGSLLACGFFSFLKMFQYTTVNPGQDFNEWEAKMGPGSWNDSTHRPSYYSDATTVDRAQSPTAGRRNHTPSSSQPQNNVPNIPHGAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBV2</accession>
    <name>A0A317XBV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_220381</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471923.1">
        <property type="nucleotide sequence ID" value="XM_025606217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBV2"/>
    <dbReference type="STRING" id="1450535.A0A317XBV2"/>
    <dbReference type="GeneID" id="37108360"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="145"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="365"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY95162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="415" mass="46078" checksum="7752F2E0CCB53BD0" modified="2018-10-10" version="1">MPADYSSTARALSVSTSSPEPLSPSEDDAYPPWSRRAPGRRNSASLSGGRTATLRDQLIDRGTQMLHRIREAWRKMNFWQRVGAVAAILLANLLGIGFLVFTGKVFIWIQPVAAQWEKSSLAYFVLWLCVFFVSFPPLVGWSTFGTVAGYLFGVWKGWLLYASATVLGSTCSFIVSRTILSKFVRRLTERDTRFAALSLTLKYDGLKLLCMIRLCPLPYSVCNGAVSTFPTVSPLMYGLATALISPKLLVPAFIGNRLRVLSENNEEMSAGSKAVNICSIIVSISIGIFTGLYIYRRTLARAKELEAKEREDIRHSLQADHAARRPHGAFSEDPDVDIAATTLARDEEAQIGFTDLDDDHVDLAIDDESGSETSPHRTKATPYRDEFTDNDSDIFRDGDGASEEMYTLHTHMRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC01</accession>
    <name>A0A317XC01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mannosyl phosphorylinositol ceramide synthase SUR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_572094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471249.1">
        <property type="nucleotide sequence ID" value="XM_025614904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC01"/>
    <dbReference type="STRING" id="1450535.A0A317XC01"/>
    <dbReference type="GeneID" id="37117047"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="368" mass="40683" checksum="6EA9A2292CADBA90" modified="2018-10-10" version="1">MAASTALKNVGSCIQHQAARCQASLPVVSLAPRLQSVVTKARRGPFVCCFGFYVLFICVSSLLSLLQFSSALHAKTLTPDVIWADSSPVAASQVPATEMQWAPPPSGLVLEPSNATAIPKIIHRMWRGLASDVPEEWKNATHSCQEQNPTYQQYIWTDNTARQFIGAHFAWFLPTYNEHLLSMQRVDAFRYFVLWYYGGIYLDPDVGCRQPMDPLLRDTEALLPRSWPYGVSNDLVASTANHPFIIKVALSIHDHQWSFVPAYVMAFISAGSMLVSRVLAMWLRSIKGNPGISIVPPTLFDSTEDAFFMRFEGLLPRGDEVAVSEQVFGNWLGWCGAGIALIVMATVIFGVQTTPPTTRRDSTASVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDN7</accession>
    <name>A0A317XDN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_529832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473206.1">
        <property type="nucleotide sequence ID" value="XM_025610536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDN7"/>
    <dbReference type="GeneID" id="37112679"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="178" mass="19878" checksum="3000C3297F37320E" modified="2018-10-10" version="1">MTKLWAWRTIIAGGHGGQLEDTAWPDFLQTLACCFTTPVPTRGEVSLPRTFWDVPPPANSLALGRVTCPPARYRPCQFKEYGAVPEGVERFFPRCTLTLTWKCIPSLALIGLRNPWWLDTILLDMSADRQIAPNLVATMFIPCTYTQIELYGVQQGFVGFDRSPGISDTVGPAWISTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDV3</accession>
    <name>A0A317XDV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_580555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473485.1">
        <property type="nucleotide sequence ID" value="XM_025615334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDV3"/>
    <dbReference type="STRING" id="1450535.A0A317XDV3"/>
    <dbReference type="GeneID" id="37117477"/>
    <dbReference type="OrthoDB" id="4088837at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="49"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY96724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="574" mass="61670" checksum="BD6F7103AD4B1270" modified="2018-10-10" version="1">MVSSKETPTAHVAVQGPQGPGAPPELDSPGVKRIEVLSSYLWNIDRVFLFSGIFLVAYVYGLDGQVRGTYQPYATASYGSHSLLSSIDILRAVIAAAAQPTAAKVADVFGRVELILVSIVFYTIGTIVEASSNTVEQFAAGAVLYQIGYTAIILLVEVLVADITSLRSRLLFSYIPALPFLVNTWISGNVTGAVLGTTTWRWGVGMFAIIYPICTIPLLVTLCIVHRRAKSSGALDDIRSSFRTLGAYRLAKELFWYLDVIGIVLLIAFLALILVPFTIAGGLASQWKTAKIIAPLVVGLCCIPVWVIWEKTCKHPMVPFKLLKDRAVWGALGIALMLNTAWVLQGEYLYTVLIVSFDESITSATRIRSLYSFASVITGFLLGFVVFKVRRLKPFIVGGTLLFMVAFGILIYYRGGPTSSSHSGIIGGQVLLGIAGGLFPYPAQASIQAATKHEHLAVVTGLFLACYNVGSALGGSISGAIWTQVLPGELNSRLGNATLAAQAYADPFTFSATYPMGTPDRDAVVAAYKSTQRLLCITGICLTVPLVAFSLCTRNMVLTKEQSFTNAEEDSDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XG56</accession>
    <name>A0A317XG56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_541034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472949.1">
        <property type="nucleotide sequence ID" value="XM_025613028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XG56"/>
    <dbReference type="STRING" id="1450535.A0A317XG56"/>
    <dbReference type="GeneID" id="37115171"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="10"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="431" mass="48471" checksum="71DD981B71845DAC" modified="2018-10-10" version="1">MALSASSREHWLDGLRGIAAAIVAWFHFTVGEMEPPYRSFWTIPAEDNRRWFQLPPFRLLFAGQAMVLLFFVISGYAVSISIIRLREESQAQFYRKLTSSVLRRGFRLYIPVLFLCLVSHAALYTGLIDWTPGNPKEGCPGAEPWSALGPHVSCLTMTFLTTLDLTGPFYVTGYNFHLWTISYEFRCSLGIYLVILGLASVKAKVRLVAVACLGAVFMWFGSPILSAFLAGLIFAEVDVAQQDDLSPPTVGKRYRGLAKCTSLLPGLLFGIGIFLLCLPQDSSFPADFWFQSQLALPFYVDPEIRIRGWHAMGAILVVGTLRHLPLVRAPLESNVAQFLGTISFSIYLLHPLFIMVIRNRILEGVCRHLWGTDFWQTRQDESAWHVLFLAWVVAGAIMGPLLVWASSYMARSVDRRSVAWSYQVEKILCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGD2</accession>
    <name>A0A317XGD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin AspB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_541152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473079.1">
        <property type="nucleotide sequence ID" value="XM_025613035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGD2"/>
    <dbReference type="STRING" id="1450535.A0A317XGD2"/>
    <dbReference type="GeneID" id="37115178"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="148"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="493"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY96318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="524" mass="59074" checksum="A0E922DAEBF89265" modified="2018-10-10" version="1">MARSRNRSADGRSQGDSEALALSPQKGSERVKRHSYSPVLDRLSSESERQDPEPDADAASDNVATPPPAPVANGTPVSASPPSSKPSSPFVERSNPMGAGNAQTVSSKDPKAVAQAATDMKNVVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLVNTLFNASLYPPKERTGPSHDIIPKTVSIQSISSDIEENGVRLRLTVVDTPGFGDFVNNDDSWRPIVENIEQRYDAYLEAENKVNRTNIVDNRIHACVYFIQPTGHSLKPLDIEVMRRLHTKVNLIPVIAKADTLTDEEIAAFKQRILADIQHHSIQIFEGPRYELDDEETIAENQEIMSKVPFAVVGANAEVTTPDGRKVRGRSYPWGIIEVDNEEHCDFVKLRQMLIRTHMEELKEHTNNSLYENYRSDKLTQMGVAQDPSVFKEVNPAVKQEEERALHEQKLAKMEAEMKMVFQQKVAEKESKLKQSEDELYARHREMKDQLERQRLELEEKKTRLETGRPIEEKGKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGU8</accession>
    <name>A0A317XGU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PTH11-like integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_552196</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473369.1">
        <property type="nucleotide sequence ID" value="XM_025613585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGU8"/>
    <dbReference type="STRING" id="1450535.A0A317XGU8"/>
    <dbReference type="GeneID" id="37115728"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="42"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="372" mass="41282" checksum="B1D2809CF3884D81" modified="2018-10-10" version="1">MLDEIVGSILLPRGINDDAARGQRALVVTAVLTGFSILIVAMRMYARVGLMKLIGREDYMILISLVLACTYLGLVAAEVHFGLGKHSADLSTHVLKAQLKRLWAAIPFYNASLIFTKFSILFQYLRIFPDRRFRLACYVALGIVATYGTWAVISGFLNCVPVAKFWNSDVPGYCLNFEAVWFFNASMNIATDTTLLIMPMPLLSQLQLPRMQKLALMGVFAIGGLVVITSILRLSSLRSVAQSKDTSYSNVGAAYWTAAECNVAIICACLPFLRPLVSRIFPRFLSTNSYTRNPTMSASRMTAARMTARSHRQKVELYSQDRDYGMYTIDVKSGEANHDGTLAGIEVTTTTMIQESSRNCKSTSQRRLVVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UTN8</accession>
    <name>A0A317UTN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_480438</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000068">
        <property type="protein sequence ID" value="PWY64729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461314.1">
        <property type="nucleotide sequence ID" value="XM_025608794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UTN8"/>
    <dbReference type="GeneID" id="37110937"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF156">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY64729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="560" mass="60674" checksum="E9C9AD4CD86E9CA7" modified="2018-10-10" version="1">MGHILAVVPHEPHPEPISEKPNIDTDTDGTEIPAASADDVEPAPKKSLAFKLSFIGLAAGLFVFQMDATALGIAIPTIAEDLEGQSLESFWASMSYTLCGLVMQPVWASISNAFGRKPPFYVSMGFFFVGSIIFAIAKNMNTLIAGRVLQGFGGGGIDVLAEVILADMTTLQERSKYLGLMAIPTSIGIIIGPCVGALFSTYASWRWIGWINLPILGIGTPLVFFFLKLRPIPLDAGLSQNLNRLDWIGMMLLVIGVTIFVLPLSWAGSLFPWASWQTLLPFFLGIAVLVIFAFYEAKPATPIVPHRLFHSKTANMTLAGAFIHGVILITLLQYLPLLYQAVQLKTPIISAVSLLPTVITSVIVTAVSMMLVPWFGGYVWILRLAWAITALGAGLLALFHVGSAPSLRFGLPIIWGVGVSLLRLSILPMQASVKHVDDTGLVIGPFLTIRMFGGLVGLTIASSIFNTVFASSLRSSNVQLTGPLEPLREVSNAVAFIDKLRSLDVPRESLDQVLEVYLKCFQTIFYTMTGFSGLGLVASIFVEEIDLKGRSQGKQRFEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UW60</accession>
    <name>A0A317UW60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_480242</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000060">
        <property type="protein sequence ID" value="PWY65268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461393.1">
        <property type="nucleotide sequence ID" value="XM_025608784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UW60"/>
    <dbReference type="STRING" id="1450535.A0A317UW60"/>
    <dbReference type="GeneID" id="37110927"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY65268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="332" mass="36011" checksum="BC89F935240354B1" modified="2018-10-10" version="1">MSIPQTMKAVQVEKLGGPEVLEFKPDHPVPTPKEGQLLVKNNISGINYIDTYFRTGLYASAKPEILGREGAGTVAALGAGPNPYNFQVGDRVAWLSTGGYAEYTAVPMAKTVKIPEGITDEDLMASFLSGLTVITLAKETYAVQKDEWVLLHAAAGGAGTLMTQVLKSIGAKVIGTAGGPEKCELARSLGADVVIDYRSEEGKDWVKKVKEITDGRGVDVVFDSVGQDTWEGSLECVKRKGTIVWFGNASGPVPPLPLQKLAPKCVKVARPQLFGYIETREEFEYYVNELFSLLLSNKLKAKIHKVYPLEEVAQAHTDLESRKTTGKSLLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWU0</accession>
    <name>A0A317UWU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_479725</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the YPI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461610.1">
        <property type="nucleotide sequence ID" value="XM_025608758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UWU0"/>
    <dbReference type="STRING" id="1450535.A0A317UWU0"/>
    <dbReference type="GeneID" id="37110901"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY66155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="172" mass="18794" checksum="E135AFEA81C04755" modified="2018-10-10" version="1">MSRTRQVPSEAASSSQIQSTEEHPNNPSAVLVSATLRLRAGDGPAASTFNQDESTSRHIRWSEDVIDNEGMGKKSSKVCCIYHKNRSIGDSSSESESSDSSAPDSDTDSDSESGYHRRSGQRRPSNQNDNHITCDQRASPGGERPAHRHAKKAKRKPSPNAYEKMPKTAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXW5</accession>
    <name>A0A317UXW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome regulatory subunit S5A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_540823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000058">
        <property type="protein sequence ID" value="PWY65352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461418.1">
        <property type="nucleotide sequence ID" value="XM_025612996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXW5"/>
    <dbReference type="STRING" id="1450535.A0A317UXW5"/>
    <dbReference type="GeneID" id="37115139"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3990:FF:000001">
        <property type="entry name" value="26S proteasome regulatory subunit S5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000128">
        <property type="entry name" value="26S proteasome regulatory subunit S5A (AFU_orthologue AFUA_2G15070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="6"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="189"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY65352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="276" mass="29807" checksum="3DC511C492547E5A" modified="2018-10-10" version="1">MSLEATMIVVDNSESSRNGDYTSTRWQAQIDAVSVIHTTKMRVHPQSAVGLMSMGGKGPEVLSTFTTDFGGILAGLHRTKIHGTAHLSSSIQVAGLALKHRSEKSQKQRIIVFSCSPIEEDEKSLVKLAKKMKKNNVSIDVIAFGDLESDQTKKLEAFVENVKGGEGSNLAIIPPGPNLLSEELQLTPILGGDGADAEGAGPEGGDGSFGFEDAAENDPELAFALRLSLEEEKNRQEKEKRDREEQERKANLENIPEEGSSGSKDKKEDGDKMDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYV9</accession>
    <name>A0A317UYV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_504690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000056">
        <property type="protein sequence ID" value="PWY65682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461509.1">
        <property type="nucleotide sequence ID" value="XM_025609517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYV9"/>
    <dbReference type="GeneID" id="37111660"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY65682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="38677" checksum="627F4838742D01F2" modified="2018-10-10" version="1">MARTKQTARKSTPGCAPHRQQRTVHQYPDHTGKVYTVVDGPVTGCTSTTPAIRKLSIHLYSLSPLSPSPETVGRDLLSSDGIQGWGNARNHWPRVDVYPPMGSIEACIEHHRREKVFRAERKREMVREVADSAAKAFAKDCGDDEVRDEEEAVQEAIAMLRGKEPLPHIVPTWCCAVRFWGPYDYRTRYRSFILVVPEGCSTWEDIKKMGLWVVNFDLDWGPTMDTEMEDWEPEWDEGALIVEKTGWVWVEKRPAFKTSLYHVWSDLTSSLWDCTYRIRVCDRCEDQVPHEDCEGEMDEHYFDEDGQCVACRRATEYRRRSKRIAKRKVDSMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZQ2</accession>
    <name>A0A317UZQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_540653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461632.1">
        <property type="nucleotide sequence ID" value="XM_025612962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZQ2"/>
    <dbReference type="STRING" id="1450535.A0A317UZQ2"/>
    <dbReference type="GeneID" id="37115105"/>
    <dbReference type="OrthoDB" id="3891049at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY66368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="137" mass="15286" checksum="8A68146905B7A15F" modified="2018-10-10" version="1">MVTVVLTDVSFMTNTPVITDQAEEQDVYEGYSNFVQSLLELMDAFSTSATLLESIDAVTKYKVPSEVRVLESAVDAYFYNIIGLFPANSSYNAQANNQKAQVDTHCFQAIWAFDLDEGNQSRSDASLHSRWLRRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V012</accession>
    <name>A0A317V012_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_561443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461612.1">
        <property type="nucleotide sequence ID" value="XM_025614217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V012"/>
    <dbReference type="GeneID" id="37116360"/>
    <dbReference type="OrthoDB" id="4381212at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13085" checksum="01FB3F9F92A0D369" modified="2018-10-10" version="1">MANNWRKRKALELLPPPPCRASLAGRQSKPLNQGESSPPQGGVSPERAIAPTHASSNFMLDQPDTVCPGCGSQPVSSRCPWPIARQLRVLSSQLAAASFCYEVRHPINGLNFRVHPSHYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V014</accession>
    <name>A0A317V014_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NACHT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_613675</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461686.1">
        <property type="nucleotide sequence ID" value="XM_025616706.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317V014"/>
    <dbReference type="GeneID" id="37118849"/>
    <dbReference type="OrthoDB" id="2546325at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF9">
        <property type="entry name" value="NACHT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G01760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="299"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1913"/>
            <end position="1936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1914"/>
            <end position="1930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY66488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2021" mass="227038" checksum="043C81F8FDF4C6C1" modified="2018-10-10" version="1">MATSFQPNVHYTFGTPLSPTSLFGPRRASDILEQENYTNTVFQAGTSRRGSRKLSGGNTSLADVVNSLARRSSDAMMTSKITDADYASLLEWIRSDRMHKLPPEGSSYDKALVWAALFVERLHSFDSAIEQFAGDSHMAAQLAYVHCASLLEHGEQNAPALQDLFGFFYRCSVGLGNLLDRVELFTVSQDIKDQLVLALADLVTLVVGVASHFHRSLLTSESVSIDICSTFPGPIDSFRGRCEHVSELMWRHQLMREGLNGDKVTEIKTIRDWLEPEDPVLANITETTAHFAQEREESTCLWATQYLTRFLKGQQQILSFVGKPGSGKSILSTVINDLLQHPIGGVTYKSIFAPINTRIPANTTPRAIAKTILSQLFSKRIGNVRLYQILADAYSRSQTTIEEEDYDDVLWTALGSALKASLQGAKQLVLVVDGVDEASCGETVLLKRLHNAAQNATNVKLIIFGSHKQTSSASHTAVNITPELVFDDIAAVSRKILQQSPAFTSMSGEDQEINVTRITEASHGSFLWAKLATKRVREEHPSNAEGLAKSIESVAKAGYSITDLVSHALRAKLSEDGKKIITWLATAVRPLTQQELTALVSIDLEKSSITEREVDLPHVLKPVASLVFFQNNLVFLRHGQFRTAILDIFAKDKFLPAIKNRNSDLTQRLLLYTKHSVTESHDPSLTPLDESVVDTHLDKHPLLDFALRYWVNHAKIAFGCTTDQEIVTAAKELQSVIPTSPTVPLLEMAVWEAKSTPALKSLHEIQTRLYRQILTTNHPTTLQTILCQALFYRRIHDSLPAQISQIFYDAAQISKDVLSDRHLITMQMTKFFLEITADQTSDSKTDIMVKRVEMLELLVECYKVHYGATSTTVTSTLSQLVEHYHSIKEEHKAQQITTLLQGSTTEGHHQRSGSRQMDESLLVHLRGRQDTEGGTALALDGVEADELITWSVDFESLFSKAEKAVAAGHMKEAESAYVELWQQASKEYRLRENEAASILEGFWEEYEQSTSTSQAVLSQFLEVAKVMKSVGMSVLALNVFKHCCQHSSHESSTYKEAEQHIKSTSREVLRMASSSTSAVTESTLQEIVYESSSTDQESISATKNLVEIYLAQHRWHDATRTLKQVLRGVWPALFAPSLDDVVLPSTNVEYAVELAERLSNCYRSRRHHIKEEDIRGRLYRAVRRDRPAGDKLLSRVTLSVLRLYERTSQTDKAITVHQDILNAYTKRFGSDHPTVLKELWTLAELTRPRPVAVDYYRQIVHILNKDSETCHPDAFEPLLIVATELLNQARYPDALKPCRVLFNTMQNPKISQKLQDQAFVQTIYERYVHCLRMVHSDTASIHDVTVQYRKSCISLFGANATVTIQATKILANICQESKRYEAEAIQLYEELLRTKSTEVEIDHQDIRATLDAIYEEQNVSVTSSKFEAMSTQEAQKWVSIRTKRLSSIRTTQGWAHEEALSQMEEIVSLYSKRGETHTAASMLQEATTQILSTETSSTRLTAAAKSIASSYIATGQVEKAKSLSQEIYRQLVTKDTSNVSSYGFNITTNQRQSLAFLAQLEYSLRSREDSTVTLNEIYSALTTEYLYFEQFRTEMSSKTSSLQKVTISVARLHGFLLARGRQSAATRVLEQFTNYFLATEGAGLKVNSHQAKVFTETILDYFSTHKSQDLIRSVAIASYNRTTQLLASNNYQSACDLALTAFKYIWAHTGYSSEATLKLVFKLGLVIAGRDLKARPAASIRKEMLRVSATIMHDTLDYFKKHNIDLSQLDLVNLNSLIGILDEQHDYQTLAWVLTSLWTSRDAYELSQPQYTYTLALGRMLVITRYLIGEYTSAIRLAEDIVYNCARVHGPRHPSTVEMTVLLSQMYTSVAQGYQNQKDRRELAYRYYKKAAGLHENALRFFIDPTSVSSTEMESGTISGLSSPSSSPGEATEEEGKYVRQHLHLLKLAVERLGDWPKEYSEYERLNTDLFRTFSNDLKGVEGIEKWNLKRFGSGKAEASDDLISEANQGVGFYERLAIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V042</accession>
    <name>A0A317V042_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_590886</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461972.1">
        <property type="nucleotide sequence ID" value="XM_025616069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V042"/>
    <dbReference type="STRING" id="1450535.A0A317V042"/>
    <dbReference type="GeneID" id="37118212"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="58"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY67623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="514" mass="55985" checksum="9F1A1B3C01E9BEE4" modified="2018-10-10" version="1">MSHDIKDKGPQETVHTIELGSLGGNASSASLQPLSRASSTPPPEPPYTVLTERQKIMTITIAAIVGFLAPVSANIYYPAIDQLAHDLHVSVSQINLTITTFMIFQGVAPLVTGSISDVYGRRPTMLVCLITYLGVNIGLALQDNYIALIVLRTFQSCGSSAISVVGMAVTADVVTRGERGKYMIYSSLGITMGPALGPIIGGVLAQFMNWESIFWFLAIFAGAMIILILLCFPETCRQVVGNGSIPAPRWNRPLIPIIKPSQLDGDETARNALAGAPKVKRPTPWDSVQIALEKETGALIAFTSLLYCGYFAVLSSLSSQLSEKYNYNSLQVGLCYIPYGIGSLSSRWTIGRFVDWNFRRLGKQRGLEVVNNRQVNLIDFPVERARLQITLPMVYLACIFIVGYGWVMNYNVNVAGPLIMLFFTAHTIAGATSTLITLLMDCHVQRAATVTASNTMFRCFLGAGAVAAAVPIINAIGMGWMGTLIAVMWLASSLLLWWVMLQGHDYRKKKAARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V1T0</accession>
    <name>A0A317V1T0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_540712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461605.1">
        <property type="nucleotide sequence ID" value="XM_025612975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V1T0"/>
    <dbReference type="GeneID" id="37115118"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY66150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="75" mass="8557" checksum="54EE51379F34CC9F" modified="2018-10-10" version="1">MRELIRGNCIVGLELMLTDWCVSEGRSKFEIRGSRLTIYTKRTFLERNSLGLRSAFWELSCLKSSQLGGRSLGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2L8</accession>
    <name>A0A317V2L8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ER-golgi SNARE complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_590662</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462197.1">
        <property type="nucleotide sequence ID" value="XM_025616049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2L8"/>
    <dbReference type="STRING" id="1450535.A0A317V2L8"/>
    <dbReference type="GeneID" id="37118192"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="251"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY68534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="343" mass="37616" checksum="7EF6D6379136E98C" modified="2018-10-10" version="1">MAGPSIQDRTGEFHAILGQAQKRIASNKAGAQRQALLSDAQRKQANGSADGQGGKRRSEFARRAVEIGRGITATTAKLQRLAELAKRKTLFDDRPVEISELTFVIKQDLASLNQQIASLQALTLSQHPKSNRPKADQEGEHNDNVVVMLQGKLADVGANFKDVLEVRTKNIQASRSRTENFVSSVSSKTQSALDTQRSDSPLYNTSGRRTPQPGGAADLLTLEPSNPSPLGRPSIHSDQQLLVMEEAQTSNAYIQGRGEAIDAIERTISELGGIFGQLAQMVSEQSEMIQRIDANTEDVVDNVQGAHRELLKYWTRVSGNRWLIAKMFGVLMIFFLLWVLISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5S8</accession>
    <name>A0A317V5S8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_550809</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462471.1">
        <property type="nucleotide sequence ID" value="XM_025613508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5S8"/>
    <dbReference type="STRING" id="1450535.A0A317V5S8"/>
    <dbReference type="GeneID" id="37115651"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF17">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY69643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="506" mass="55708" checksum="D35E44BE64C7BC1F" modified="2018-10-10" version="1">MVATDSGRSTKSRGCFQCSKRRIICDLGEPVCLKCQKKGIDCSGLGRFRFTACVATRGKLKGCTIPVVDANPDTAYKLLSDVPSSIRWRHDRNKVAKKQKPGDGGRVGIGTGKVGRLEPNAPALSDARVLANSGQRTLDMDTHGAVDGFIVETDLENAKALSTTVTNGDTGLILAQQGYRHTTQDHGQQFLHGKFSLRRWIAPIDHKTRQSFDYFAKYVAPVMVVLDISNGYRDLILPMAFEDELLQQAVSVVAAQHLRPRQPSSQATTESNRSAIISRLRSASQLGSPDLVFNQSTWATLIVLLVGETVTGSSEYSHLLQTLLTLASNMRAVENSELNEFLTKQTDMFAFLGQPLLNEDLGAEQLRNPIDPGVWMASGVHTDFHHDRTLSLVKQGFAMGAQIYLQRATTNQSSWDALEGLRQLLCQVNPTEPGAHGFVWSCFIAAADSVDPAHRSFFTNYLKGIHSRTLFDNIPKALAVLPAIWEQQCSRKWTEDLPSLSPILIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6U7</accession>
    <name>A0A317V6U7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_590563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462296.1">
        <property type="nucleotide sequence ID" value="XM_025616039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6U7"/>
    <dbReference type="GeneID" id="37118182"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="101" mass="11200" checksum="B840A7CD6CC3CB23" modified="2018-10-10" version="1">MPLKSTFTISPVPATQEASRHLNSIERSAIHQSNDTSFVRLMWNNSPPDENEDAEFMLQTGLLGQFSQVELDPDPDPLEDPDRCHEHTGLRALGIDAEDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDW5</accession>
    <name>A0A317VDW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sterigmatocystin 8-O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_569057</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463260.1">
        <property type="nucleotide sequence ID" value="XM_025614717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDW5"/>
    <dbReference type="GeneID" id="37116860"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="55"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="208"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY72486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="357" mass="39454" checksum="AC978DBC37CF81BA" modified="2018-10-10" version="1">MSLESQITALTSAVQSNRESLDDAIRFKAIKAAQGLLAALGSPAETVIQDVVMNSVLLMALRMGVQLGAFTAIRDNQGHATTTQQIANKSGASVALVDQIMRLLTASGYVLEEDVQTYKPSPLTMVMAEPTFEATTRACFDIGNFYTPFQLAMNTELSYFEWLGHNPELARDFQQWMTLKQQATPNWVDWFDIRGSILDGFNSSADSVLLVDVGGGEGHYLHALNEKLPSLPGRLVLQDLPHVVSSIENPPKGTELMSHDFFTSQPVKDEQARKILTHIVTAMEPGYSRLIINDYIIPDRNCDFPTACMSIMMMVQVGAFEWSEKQWRELLNSVGLKDLIFHQPPGSGEGIIEAIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFJ6</accession>
    <name>A0A317VFJ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_525150</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463428.1">
        <property type="nucleotide sequence ID" value="XM_025610299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFJ6"/>
    <dbReference type="STRING" id="1450535.A0A317VFJ6"/>
    <dbReference type="GeneID" id="37112442"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="237"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="802"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="894"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="894"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY73163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="919" mass="101632" checksum="44CFC48BD9B1865A" modified="2018-10-10" version="1">MSGRILSHRLVPLLRTGLLARHVHNAAARTGGLLRSDGSAALRGRAWPIGANAIHNNVPAVRAISFTRILPKLALKLVKLPAMFGGAMVAGLAYFQYQATQAGNYALDVFKRAGETASDAASSLFQEIQGIADQTQRGWEKTKEAVEVPEWLQNILRLNEDSRSENGGPGGDEPPKQSRLGAATAGAATVGAFGYEPSDEEDTRSERKIAEDDQMMLLTRKMIEIRNILQSVGQSNTLTLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGSNMVTRRPIELTLVNTPNAHAEYGEFPALGLGKITDFSQIQRTLTDLNLAVPERDCVSDDPIQLSIYSPNVPDLSLIDLPGYIQVAGHDQPPELKQKISDLCDKYIQAPNVILAISAADVDLANSTALRASRRVDPRGERTIGVITKMDLVDPERGNDILSDKKYPLRLGYVGVVSRIPQTTALFSRGSGNVTGAILKNEHAYFSAHPSEFGSQSGVSVGVSTLRTKLMHVLEQTMASSLAGTRDAISQELEEATYEFKVQYNDRPLSAESYLAESLDSFKHSFKAFAESFGRPQVREMLKNELDQRVMDILAQRYWNKPIDDLSAPLPELDPLSDLAKADPESLYWHRKLDASTSSLTKLGIGRLATTVVANAIQAHVDRLIANSTFATHPYAQKQIVDACNSILNDRFFSTSDQVENCIKPFKFEIEVEDPEWTKGRENVSKTLKDELKACEAAFKRLEDSVGRRKLKDVMSFVDKARKGEVFLEGDGAGGAGGFSSALIARGRESVFLRDRADLIKMRLLAVRSKQCSAKKNKYYCPEVFLDVVADKLTSTAVLFLNVELLSEFYYNFPRELDMRLGRHLSDAEVERFAREDPRIRNHLDVIKKKELLELALQKIESIRQLDGRGKNRNPDRPVGSREQRNRGWNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGB0</accession>
    <name>A0A317VGB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_539317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463144.1">
        <property type="nucleotide sequence ID" value="XM_025612682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGB0"/>
    <dbReference type="STRING" id="1450535.A0A317VGB0"/>
    <dbReference type="GeneID" id="37114825"/>
    <dbReference type="OrthoDB" id="5374569at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="277" mass="30082" checksum="609CE155D632D085" modified="2018-10-10" version="1">MMVEDEFYAVAQTFTQHLHYAEYLRRKKEAKLQNATAIQNIARPTDGVTPTSEEVRKKAAAAELSAQQKAGLQKLGNRPAVDSEEETEGPEEDRIWAGTSLHDLMISPRKVRSLVGMQGIKSSTRAAAGMQAAGTSRGSGDSVTDGAAREAEDDLLGETTGEDDDLDARTRTPTRPSRTQPRSTSSLRSSSLHRATGEGGMRSVQSMSGRYSTPTATKSRKRLLFDDFDGLPEPHQSPIELQGQKSSSSLGGRPPNPRGVDPKAKKSRLNEVPTFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHQ0</accession>
    <name>A0A317VHQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_608093</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463322.1">
        <property type="nucleotide sequence ID" value="XM_025616552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHQ0"/>
    <dbReference type="STRING" id="1450535.A0A317VHQ0"/>
    <dbReference type="GeneID" id="37118695"/>
    <dbReference type="OrthoDB" id="2283631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="90"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY72548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="856" mass="96423" checksum="EE0B8B2629791712" modified="2018-10-10" version="1">MQGFSFAPPTGPPREGQKNYVFVDEHNRHKRLKVMRACNGCRKRKIKCDAATTNTWPCSACTRLKLVCVPPTIGHDGEYSAAESVEANTSDALNASTAPEPALSSYTSQSFRDGGQPAIGNMHPYNDGMGMYPQFAHSTSSQPNVYDMRSSQVSVPHQYQQPPMFPGDQTQSLGTAESDLYGEHDQSTAENLSEVLGELRIDETGIAPYIRQQRRERAEPEIPTQDEIDEKLPPLSTGAGSTIRIPPELMPSDDEVMNYFKIYFDDIHPYVPVIHRSHLYYQWQHERSSISPLLLESLFACAGRLSDDPAQGAQWLALANRHESSFMDEPRLSTIQALLLLLKARESRPKKGYYYRSWQTVKTIISMAKDLDIHEHNNLHTEDKPCDLNPVECLVQTRVWQALLVVEVMIGAPQGRSDYGVDPETVNMSPTLYIRGLDQFELDRSRQYAYFVRNARHIRIIADIYHKIKKQKDWGANPKFVEKNPLFTDWLQSLPSDLQVNYPPDGSPPWIPSHFVGNMHSHCHLGIILLHRPQLIASKSFAAGGGWKMHMALCYSSAKYLCRLQEAILNRFGLCGLLFMQRGINFTIYTILTCTMLHLVAITSPDPNFHTDAREYFTRHMRILERCSSAWPMPELQAQIDSLRFAFSADVNRPFELKPTFPYGSPSESYHPSPPLDSHYGPQINQVSSVQSRVGYTAYPVTPPISAGTEDSKSDSSQLQPLGLIPSHSMSTHAINTPLVDENSWDPTRIINQWDMAFSIGTPTVTTNSPPMALSNTQAVQPSLPEHFPVPYEQQSKVASVAPTPVPHAQFTGQQVLFTARDWQQSVASVYDPNGLKRRWNYSVDMGTENTSKRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIN0</accession>
    <name>A0A317VIN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_474964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463537.1">
        <property type="nucleotide sequence ID" value="XM_025608542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIN0"/>
    <dbReference type="STRING" id="1450535.A0A317VIN0"/>
    <dbReference type="GeneID" id="37110685"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000467">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000174">
        <property type="entry name" value="Cyclic nucleotide-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="64"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="266"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="11">
        <location>
            <begin position="540"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="487"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY73785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="924" mass="102044" checksum="4C7F28FA4E8D41DC" modified="2018-10-10" version="1">MRRHGRTSGGSTKAVHPISDTASLLHSFDSLTNPNRPVRPSPLTSSNIQALPLDLVDRLRSFPLFQSTPESFLIDVGQHLRPQLHAPNDYILTEGDEAKAIYWLVRGAVSVTSRDGESIYAELEPGAFFGEIGVLMDRPRTATIIARTRCLLVVLTKEDFRSILPRFPDVERAIRDEAQERLMILEKKKKETSAPPVDLVSPARKGSKRLRDACSGDLSLVDQDGRSLKSVNKKRKSPSPGLADGSSSALANGLVNVRLLLKELPLFAGLPPDILHFLGLNAQPRSYPPFTDIIKQDSQGREIYFIVRGEVEVLSERTQMQHAHSLPNTIEHPSFEVKARLKQGQYFGEVVSLSLAPRRTATVRSISAVECLMISGEVLVEFWERCPPKVRGQVERTAKERLQSASDGDVVMSEAGSAEQPASELSVDDNFKIRAARRQSMPLLTLTETELDSTPKVNGVDEPSVLRPSDPDPFLSVGLDKVRLRSRRSSVAPLTPEEVAGEQQRSSPPSEPRSTSSSFLTLPGAGEFSAPSEILREPRRDNHGLLPDRVLLVIFQHLELHDLLRLRAVSMHWSEILSKSTELLHDLNLSSYNRCVTDDVLVKIICPFVGSRPRYIDISNCFHITDEGFSKLVTTCGRNVVGWKMKSVWDVTASAILDMASKANGLQEVDLSNCRKVGDTLLARIVGWVAPGQHKSNDETGKTSKASMKPTRQTAAGTVFGCPELKKLTLSYCKHVTDRSMHHIASHAASRIEQMDLTRCTTITDHGFQYWGNAQFTNLRKLCLADCTYLTDNAIVHLTNAAKQLQELDLSFCCALSDTATEVLALQCSQLTYLNMSFCGSAISDPSLRSIGLHLLHLNRLSVRGCVRVTGAGVEAVADGCNQLMSFDVSQCKNLHPWLEAGGPRKYGKRISFETVALNGRVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIV2</accession>
    <name>A0A317VIV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_475391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463392.1">
        <property type="nucleotide sequence ID" value="XM_025608565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIV2"/>
    <dbReference type="STRING" id="1450535.A0A317VIV2"/>
    <dbReference type="GeneID" id="37110708"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000115">
        <property type="entry name" value="Cytochrome P450 monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF228">
        <property type="entry name" value="P450 MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G03930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY73127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="496" mass="56757" checksum="F914ADAFC49AD5BA" modified="2018-10-10" version="1">MSLSILPVSLLCFLLYKYLLHPYFLSPLASIPNAHPTSPITSRWITAKRTSTQEVHTIYAAHRRLGPIIRLGPNELSINSLFGLRIIYTGAFEKHSFYSDAFINFHTPNLVGMLPNKQHAHQKRMLSSIYAKSYLQNSSDLRVFSTHILRNRLFPILNNLAHTKGTVNVLPLFQAVGMDFTSAFLFGLRNSTRYVLNLGEWKDWLAEYERFKHQSREERYRGFIENWCLGLCEKMQNLARKEDQQVPATEAVVFTRLKTELEKSPDDRPLDLAIASELLDHLVAGHETSGITFTYIMWEMSKRPELQARLREEVRSLSGSLKYAERNEELPRLSDIDGLPLLDAIVRETLRLHAPAPAQLPRVTPPEGTWLHGYRIPGGVQVSSSAYSLHRIEEVFPSPEEWIPSRWMDVEDGKIHDMRRLFWAFGSGGRMCLGSNFALLEIKMVMAAVYANYTTKVVDDEGIEQNLEFIALPRGRKLVVRFVPVEGQPVEDIHTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKL8</accession>
    <name>A0A317VKL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_539158</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="14"/>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463254.1">
        <property type="nucleotide sequence ID" value="XM_025612640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKL8"/>
    <dbReference type="STRING" id="1450535.A0A317VKL8"/>
    <dbReference type="GeneID" id="37114783"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23285">
        <property type="entry name" value="beta-trefoil_MIR_PMT4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000044">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF51">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 14 17" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 14 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="635"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="324"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="394"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY72480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="776" mass="88424" checksum="9A1AE62894574218" modified="2018-10-10" version="1">MPRSPSPSLRKRGGKKESTPVPQDNLSSPLSSKASAPRSEWDYRLAITVLTVLAFITRFYKISFPNEVVFDEVHFGKFASYYLQRTYFFDVHPPFGKLLFAFMGWLVGYDGHFLFDNIGDSYIENKVPYVALRAMPATLGALTVPVVFLIMWESGYSLPACVLSAGLVLFDNAHVGEDRLILLDASLVLSMALSVLCYVRFYKLRHEPFGRKWWKWLLLTGVSLSCVISTKYVGVFTFVTIGSAVMVDLWNLLDIRRPGGVLSMVQWGQHFAARSFALIVVPFFFYLFWFQVHFAILTRSGPGDDFMTPEFQETLSDNVLSAESIGIEYFDTITMKHKDTKVFLHSHWEKYPLRYDDGRISSQGQQVTGYPYNDTNNQWQIIPTVPLDVTETGGHKVRNGDIIQLRHTGTDTILLTHDVASPYFPTNQEFTTVPLEIANGDRHNDTLFEIKIENGKPRQEFRTLSSHFKLLHVPTRVAMWTHTTPLPDWAFKQAEINGNKNILQTSNLWFAETIESLEEDSPRLIKEEREVKHLPFFRKYLELQRAMFFHNNALTSSHPYASEPFQWPFLLRGVSFWTKNDTREQIYFLGNPVGWWIASSLLAVFAGVIGADQLSLRRGVDAVEEIWGHGARSRLYNSTGFLFLCWAAHYFPFWLMGRQRFLHHYLPAHLASALVTGALIEFIFNLEPISVVQRISGEDDPSGKAKATARIGRFVSAKERMGTKSLVAGWIATLVILSGTIYGFWFFAPLTYGTPGLDVPGILARKWLGYDLHFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLJ8</accession>
    <name>A0A317VLJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Geranylgeranyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_559517</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463843.1">
        <property type="nucleotide sequence ID" value="XM_025614073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLJ8"/>
    <dbReference type="STRING" id="1450535.A0A317VLJ8"/>
    <dbReference type="GeneID" id="37116216"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00867">
        <property type="entry name" value="Trans_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY75216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="725" mass="81297" checksum="403E52D410278DC0" modified="2018-10-10" version="1">MFKQYSHILSHKRRRSRGSTINQVLSAAQSEPASETPTANEPVEVWGYSQPLPEDDEHLKECFTTLTPRIHKYDHVAQRGSDRFVQDLTAALNSDEPQTSYLSSPVGNYASFLYPECLPERLETVAYLTELGSLHDGKAPAEKPDEPVESPRVEARKKLLEKAMSELSEKDKDGHEIIDCYRSNWLVTPEVPTAENCANLDDYVARRRLNAGIDVYWTLMGFAHGTRLGKEDQAVVRDALDAAERTMFFTNDYYSWPKEKRISKKRPVANVILFLMEHQNMSEDDAKAKAKQLIIDNEHEFVRRREALYQANSDLAPQLRKWMEVLGSSLAGIHYWCKNAPRYAIPDTVEESEEEEEATEEDGSDEEESSSEDDTEDDDDDEEEEEEEEEEAEEVQQPESEEAVEVAVWTPLAPEEESPEVQLDTSALLAPTSYARTIAVSTLQTDLLTALNAWLQVPNRPLSFIKQVITELQDSTLMLADVQDQAVLRDARTPAHLVYGPAQCMNSAAYMFVRAAKILTSLNCPGMLDGLLQELEAHFVGQSWELNWRFSTHCPGESEYLAMVDQKAGSSFRLLTRLMQAASMGGSTLDFEPFAKVLGRLSQIRHEYLGLLDSSARSFGEDLDQGKVTYPIVRACNMDPAGRAIIFGIFRQKQAGAVLPIESKRQIVSLVQQTGALQATYDLIRQLGREALNALSELETAAEEVNPALRAVVKSLGEVPAPDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLS0</accession>
    <name>A0A317VLS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_578011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463941.1">
        <property type="nucleotide sequence ID" value="XM_025615200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLS0"/>
    <dbReference type="STRING" id="1450535.A0A317VLS0"/>
    <dbReference type="GeneID" id="37117343"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY75314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="242" mass="27588" checksum="B7A6E03B801F93A3" modified="2018-10-10" version="1">MSDTRTAIPRSVEEWQLQWLPTAKVNLENLSSWRRYCTSFTTQIPERTFALARHYQLQVSRVEQEDFSGGGVLFTPKIHNTRSRGQAPQLPIPPPDFTKTPPSKPDSEFETPKFDNDPDSVSRMSSPRSSQIGDIKAIIEVKPVLRQKKEAQIRIQESHQIVASLLADYKSPIIQRRAKPQEIYISLAKYDDDYIAYLQTGGIDNNPFLVMHQFGPWDTNNPRAMAELGPIPLALTLKAQHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQQ1</accession>
    <name>A0A317VQQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UbiA prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_605564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463865.1">
        <property type="nucleotide sequence ID" value="XM_025616495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQQ1"/>
    <dbReference type="STRING" id="1450535.A0A317VQQ1"/>
    <dbReference type="GeneID" id="37118638"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY75238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="36527" checksum="237D06E0FC097D42" modified="2018-10-10" version="1" fragment="single">IKTQAMALTSLLISEIVTTYLLLRSNLGAGVYLYLSAASIRLLPPPQPSPSLFPILRTFTKVLLVSLSHQYCWDIVNQVTSIDEDRINKPQRPIPAGRLTVNAAKWRWLISWTVSPVLIYTTLNSQALTIFLLSEVLIALCYVWPRFDHWSLRNVFPALWTFLTFRLLNSVICEMYPQLSTRINLDIILSLWILVTIHIQEFHDIDGDRKMQRRTLPVVLSDATSMKRLRRATATLIAAGGVGLFIWGWVKCRMGVGLLLTGVFHLLGALAVGVRCVYATSAEMDERTYKVYYILTMYWLVYFLSLVNMSVVTDGVVEGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSW2</accession>
    <name>A0A317VSW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_201120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464214.1">
        <property type="nucleotide sequence ID" value="XM_025606099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSW2"/>
    <dbReference type="GeneID" id="37108242"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="93" mass="10427" checksum="A90D2B686515BDE1" modified="2018-10-10" version="1">MTASIAADLTTLSTPSPYRYHYAPHANIPRRQTLPHNPSPRPSSQDKIQKETRVTHLSHAMPCHAMPTTNPSHPWIFNQLLPDCVTFLSCLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTS6</accession>
    <name>A0A317VTS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCNGP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_523284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464165.1">
        <property type="nucleotide sequence ID" value="XM_025610209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTS6"/>
    <dbReference type="STRING" id="1450535.A0A317VTS6"/>
    <dbReference type="GeneID" id="37112352"/>
    <dbReference type="OrthoDB" id="1714508at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012479">
        <property type="entry name" value="SAP30BP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464:SF0">
        <property type="entry name" value="SAP30-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13464">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR PROTEIN HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07818">
        <property type="entry name" value="HCNGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25561" checksum="FD746417B49978AF" modified="2018-10-10" version="1">MLGLAAYDSSSDDEVENKSPSIQPKKGDSQHSQPLQVIKDTVGTVDENTLPEKTPVTESYRPVLGPTHEQDPHHHPTEASQNLSANRTLIHDLTLPPIPNLDIPLSPSGSPNPAANAKFAHFLSLKKQGMHFNDKLAGSTSLKNPSLLNKMMDHAGIDDQAQYHASLPPEVWNANDLPSWGFKDELLKAQREIQNKAEERKLAGQRDAINFVAATPRESTRTGSVSSSRTKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VU42</accession>
    <name>A0A317VU42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_559226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464191.1">
        <property type="nucleotide sequence ID" value="XM_025614054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VU42"/>
    <dbReference type="STRING" id="1450535.A0A317VU42"/>
    <dbReference type="GeneID" id="37116197"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="69"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY76378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="574" mass="63782" checksum="C8631E28F4BF4894" modified="2018-10-10" version="1">MGLGVLDTTRAYVPGTSNILERDHSNDEPAVYSNLKYDRSGSVPILLVPQPSDDPNDPLNWPLRKRDATLLVLSFVAVLCATTSSLMAANTVTIALYYGKSFTSVALLTGYHLCGVGVAGILIVPTARVWGKRHLFLLSNALMVVSCAWAGASKHNYQSLLWARIFQGVALAPFEALLNACVGDLFYVHERGKRMALSNVALFGAAFLTPVLAGKITHSLGWEWTFYLVAIFTAAALPLTFFFVPETAFKRADHLQSDLENANDHQAVSRPAPQVQLNNLMALETTSGSGDQKQYAPSVNDHHRPTSPKELPREIETKKLTKVPYLETLKPFNGRKTDESFFKLLLRPFPLFFHPAIFWACLIQGVIIGWTVFIGVVLAAIFLGPPLWFNEVQTGYLYTGAFIGSILGLVLSGLLSDSMNRIMIKLNRGKYEPEFRILLVIFQLVFSGAGLYGFGIIAQDVARYGWLVTDVFFALVIIGMVMGAVASALYIIDAHREIAIESFTCMLVFKNMFSFVLTFFAYDWLVAHGVRPAFLAISSIQMGICALSIPMYILGKWNRSFFYRYDLLKILHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VU94</accession>
    <name>A0A317VU94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">YT521-B-like splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_472989</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464346.1">
        <property type="nucleotide sequence ID" value="XM_025608458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VU94"/>
    <dbReference type="STRING" id="1450535.A0A317VU94"/>
    <dbReference type="GeneID" id="37110601"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057720">
        <property type="entry name" value="RRM_YTH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25701">
        <property type="entry name" value="RRM_YTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="291"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="4">
        <location>
            <begin position="412"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY77159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="68031" checksum="6F042444910225D7" modified="2018-10-10" version="1">MTYPNDNASSDSTQEKSNETEKQKSHRTVAPPPQLVCSVSTTSREVPGQDNVQNYLKTQAHMTHTAQGAAPSSFNMQDMRSALPGYQSHSIIYEQHHIQQPFVHTAHPHGVIYAMPPLPSFHGATIGANMTYNTHFNQVYPSYLQRQHENLLLPHGATGYQSLVPHSPSHLNVHIPGQASGYGPNYYSQTAYTGTLGHGPGPPTTSSSAQVQSRVDFQNMQGPPIKIASRLGKETSQRRLDMEYDVSKTIVDGSTPMRPIPIQTSPADSTSHSPVSSAPRGSPRKPKQSGHALWVGNLPPGTNVVDLKDYFSQGATKELESVFLISKSNCAFINYRTETACSAALSRFNDSRFHGARLVCRLRQGTVSPGSNPDSIGSPTPTLCHDGDAKLSNTEVERAGAESRPSRTRVPSRYFIVKSLTVDDLELSRQSNIWATQTHNEEQLNQAYENADDVYLIFSANKSGEYYGYARMMSPIQDDETLTLEMPPRLDNPDPEALDVTPTPATSTAPDGRIINDSARGTIFWEAASSEDESGMGKEKATPERVEEPTNIGTQLIGKPFRIRWLSATRVPFHRTRGLRNPWNSNREVKIARDGTEIEPEVGWKLLQLFHSQFQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUL3</accession>
    <name>A0A317VUL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_523156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464476.1">
        <property type="nucleotide sequence ID" value="XM_025610205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUL3"/>
    <dbReference type="STRING" id="1450535.A0A317VUL3"/>
    <dbReference type="GeneID" id="37112348"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY77289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="324" mass="35658" checksum="4D629E533AC9A19B" modified="2018-10-10" version="1">MSAYNFQTLAEDVALDCQAVIANKTVLVTGVSPGGLGAEFAKVIALHRPSLIILANRDPLKAQQTAKEILVIAPDVPTRLLKLDLASQTQVRNAAQEVLAYDEHIDVLVNNAGVMASPFSLSEDSVESQFATNHVGHFLFTNLIMSKLVRSGKSSRVVNVSSNGHQLGPVRFHDWNFDDGKNYDAWLAYGQTKSANMLFSVSLAQKLGSKGLTAVSLHPGTIQTHLGGGRWDELYESLIKWFTLLGYFRGGQNEILWKTLSQGVATHVFAAFHPSLTASENNGSYVQDCTVSKPEHVRSWARDPIEAEQLWKLTEEIMGEKFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYC7</accession>
    <name>A0A317VYC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sucrose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_471727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464948.1">
        <property type="nucleotide sequence ID" value="XM_025608394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYC7"/>
    <dbReference type="GeneID" id="37110537"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY79376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="59991" checksum="18461184914D7713" modified="2018-10-10" version="1">MTERGNEAEPLIRHGRTGADLNILAGQRNTNETSRSSGYLFILTLAMGGLQIVYSIQHSSGSPYLLSLGMSKALLAFVWIAGPLTGTLVQPYIGIRSDNCRISWGKRKPFMVFGGALLAICLLALAWVREIVGSIIGLLGIDAQTAGAKTAVIIAATLLMYCQDFSINTVQAATRAFIVDNAPAHQQETANAWASRHVSAGNILGFIIGGMDLPRALPFLWNTQFKAISVIASVFLAITLSISCSYIEEKDPRAEPLTYAGLGLISLLQSIKASVHGLPLRIRKVYIIQAAAWFGWFSFLFYATTYIGQLYVNPIFDMHRDLSDDEVNKVWEEATRIGTLALLVNALVSFAASVILPLLVVPSERQMAAQESTGSSRSHLKLRIPGFTLRRAWLLSHFLFSICMLSTFVISSPGQASVMTGAIGITWAVTAWAPYALISSEIAQEDPGRPTQNYRGRFSEAEGSSILPYSEGADESRDAGNEGANQAGVVLGLHNVAISFPQIVSSAVGSLIFKALQKPRGEPWDTSTGWVMRLGGCAAVLAGFLTMGLEEKAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYM9</accession>
    <name>A0A317VYM9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_588331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464540.1">
        <property type="nucleotide sequence ID" value="XM_025615879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYM9"/>
    <dbReference type="GeneID" id="37118022"/>
    <dbReference type="OrthoDB" id="3527137at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="11"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14968" checksum="612EC14FBA55B283" modified="2018-10-10" version="1">MRLKVVDQECYNTGVKQINKRVEIVTVDLTINDLMNMIVDNGYDKYTYVDDGYPQNARYWFITVLEYLLWSGKIQDGGFEAINALRSVWKSQNDEIAAVQIAEPLQGIFYARDINRTLQMSGSAHPGGGNVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYX0</accession>
    <name>A0A317VYX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF1716 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_537903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464630.1">
        <property type="nucleotide sequence ID" value="XM_025612375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYX0"/>
    <dbReference type="STRING" id="1450535.A0A317VYX0"/>
    <dbReference type="GeneID" id="37114518"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000354">
        <property type="entry name" value="DUF1716 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="88"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY78118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="586" mass="66129" checksum="360FDB2736CE4146" modified="2018-10-10" version="1">MTSIDELFKKLSSAASAKRKFDSARDPNELYKAAKLDAEDDVKSKGKTPMVQDEGEEDDGYAGPELPPDFDAEDIPDDEEGRFFGGGMERQTAQAMQYIDQNEEADAAPEKFDVAWLRRFALNFEKKISKNAELRGKFENDPQKFMTSEADLDTEIKSLSILSEHSELYSEFAKLGCVGSLMSLLSHENADIAIDAIQIIGELTDEDVEADQDQWDSLVNAMLDADLIELLAQNLTRLDEASEVDRAGVYYALNVLENLASQSSVAERIGHDPNVLLWLISRIQKKERPVSQNQQYSAEILAILLQSTPKNREKFVSQDGIEVLLQLLSAYRKRDPEKDSDEEEYVENLFGCLNCLVNEDFGKQKFLEAEGVELAQIMLKEGKFSKQRALRLLDYVLGGIAGAPACERFVEAACLSTVFGMFKKKQDNQTTEHLLGIFASLLRLLPGGSAPRIRTLAKFMEKDYEKIEKLIKLRRECASRLSPIEQTIEKERKSFTEEEQEIMESEWLSRRLDAGLFSLQLVDVILAWLVAEDDGAKQKIVALLSDRDEDLSLVRNTLQEQVEGLSEDEPSEKDSKEMLNTLLQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W011</accession>
    <name>A0A317W011_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Anucleate primary sterigmata</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_626262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464917.1">
        <property type="nucleotide sequence ID" value="XM_025617346.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W011"/>
    <dbReference type="GeneID" id="37119489"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="529"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1362"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1518"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="424"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="811"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1229"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1409"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1569"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="686"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="431"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="599"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1234"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1421"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1432"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1473"/>
            <end position="1493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY79345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1622" mass="181445" checksum="49FAF3D989E8C6D8" modified="2018-10-10" version="1">MSTASLQPASSSPSPDSPNAADHAQPVRSSSTYSTTPNTPPDEGLPTLADVFRHPVSLMVEVDARGGSPSMMETSGRGGGINHHIHREPAHAQPYDSAVDTSLLLSGDYDYQERVDDQTFIREKEMRRRLMDMESSFLPEPSTIEAAAANRTLGADDTYLLGLPGDTAPIPARIEHTQISFVAPDDSSHDITAAGDGVPIPQTPTQGPRQDAAVDLDATPAASLERPGDHTTLLEAMPSSPSAAAAARSISRNQSRSSQHAHHTSQITLSESFDRSPIPDADFSLQSTHHKVRSMSRSLSPGAPRLFQDNGANDIEGASRTSSRRSNRPKYLTSRQSAHRLSYSSVTSAGTEVTNSDATLGADYALQSGGAAPGNPSTAHAGQRNTLARSVSLGSMASGISGYSDENIFERKNPSVATEGGLQTLDEEEGPSQSRPGSSYQWQQPQQQPEQLPQQQSIPDDVSGPMTPRAKPQDHSFPTDTAIAERVKDVQVPSTFMKQFREDYGGRGLSPDKRTSATPAFAKSGRTMTLKEQSSTIDRLSKENFDLKMRIHFLNEALNRRSEEGIKEMISENVELKSDKLKLQKDSQSLKRKIRDLEKQLKDQQSDKESMLNHDPEGSDEEDRDPAQDEEILFLRERVETYELEIERLRSESIARESEKRRLAEMVKSLSDGRPMGSDVGAREERDMWKDMLEAETAAREQAEEENKRLREEALRLKSEMSFPVVAARVGQRDRIGSMASYSVASEREFPRDPHTVSSSSSTLVMELELLKQENAELRKEVSAQTSMLTSRNREKERLYQEIEELKLGQRRDGNRSVAGDSIFDRSASRAHGRPSSRASDGTGHSPSDDAEREDLETRVGQLRDQVSALKLENQAIREQMDDTVRDYEALDKAYQADVDQAEEEMQNLQQERDQALQMADERDEAFQDLRAEAQEELDALGDELDQKVEECQRLGEELRVQDENLRALQAEMRSASEGIIRLEEDAQNNLQRYKAVQQELEDCNREMESLEKGLYEANTKVQRLTVQIESSQNEIAFLREEQDGDKIKIGDLESELKTYRMSLQSERDKARDLEERLAEERHQREVVGSKEKQEVQRIVNELNREASTAKEEARKLKKNLSAQEIEAATWKERLMDLENNLRETLGDLTGSRSSLISNIMKLQKELESTALELESTRSKLDDKESILRNRDALLESHGLESRKLAELLERERHARRADKQSFEQALKSHHQASRTITQNNSRISELESARNQDRKRFTTLEQQFRDQLSERNVMLLNIWKRLSAMCGPDWAHSNSLINGNLPSQEVIGNILFWPGFSRNLLLAVKTVESVISGFKSRIKGVERDLTKQYQMLEHTFSLRVKKLDRLEESMMSMRAQQHSRNQSGMSPEMAKLRGENRLLKAELNLLQSHSRSRGPPPTSAAAAAVAAGIASNSPRSPTRTLSLDPGAEAEPASLIRHHSAIEKPTPPRGLTRSATTGIPQPSHVSSTTSTMTLADGPGAMVQASRSRHMSADPSNEKWIQRLHELEKRLKAEREARLLDRSGARRRLEERDAENQRLRAQLERQRMCKELSAGTSTDDEIRGAGQGRLEGSDPGTSDGYDRRRDEELSSSEGEGIYVDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W0X5</accession>
    <name>A0A317W0X5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_521132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465155.1">
        <property type="nucleotide sequence ID" value="XM_025610135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W0X5"/>
    <dbReference type="GeneID" id="37112278"/>
    <dbReference type="OrthoDB" id="2159131at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039875">
        <property type="entry name" value="LENG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER LRC MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22093:SF0">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="35"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="298" mass="34296" checksum="B8E52F35ACFF5AD6" modified="2018-10-10" version="1" fragment="single">MTLPSSTCYPGSLTCLVLPGNLLFKMPLHLLGKKSWNVYNTGNIERVRRDEAQAKAREEEEERRMQEVDADRRIQILRGERPSTPPPPPSAPSASQPDRKAYTDDTGRSRKRRRLAGENDTDRDIRVARENAQSALVRREQQAPARSSDAPLHDSTGHIDLFPSEAKHKPVEKNAEAEKEAAEKRRGYEDQYTMRFSNAAGYRQPVGQAPWYSSSQREGIDLESALSKDVWGNEDPLRREREKARMNVNDPLAAMRKGVRQLKAVEQERKRWNDERNRELEALKMTEKRRSSHRSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1J9</accession>
    <name>A0A317W1J9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_567803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465053.1">
        <property type="nucleotide sequence ID" value="XM_025614650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1J9"/>
    <dbReference type="STRING" id="1450535.A0A317W1J9"/>
    <dbReference type="GeneID" id="37116793"/>
    <dbReference type="OrthoDB" id="5332870at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF48">
        <property type="entry name" value="TRANS-GOLGI NETWORK-LOCALIZED SYP41-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="882"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="580"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="897"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="980"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY79481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1049" mass="117071" checksum="893E1B03A59B9525" modified="2018-10-10" version="1">MADQQSIRLGREVERLVTAPYAPSLQVLQGLVETTTSNSIQLWAFHKPCQIGALVDVLVDGLSRSRFALPLLRTFVLIPAVRNVLLERYPCLLDQLLQTAIEDNRFEYASVCTAILSSPLPPDFLIPACLAPFMEKSIRAMGESPCAESILPLNQICNGIRNSPGILLEIPSETMSSLQVELTKTLRNLSDHMGNILCLATFARMASLQDLNAEEGCVRFVPSWLQNVNHFFGPKRGLKTLDLVFLRVILACSDSCNDLTVDQAAESIRLAIEICDRVEQGQRECWITANSSKIAKLREKVTRNGIDRSVQLLGVTFLASLVPDIALSPEIARVALEGLLSEDSTFVLQVLPSDYVPRLVGASVSCLGQSAIRNMLEYIVSTLTKENLTSSQSPSHVQVAKCLVAGLCNAALESFPSMIVEPLDQCKQFMGQIMNSFPRQPSCSQCNGSQMCEASLSQLENELIYDFYSFYIHASLLRNTAHKSSPEIDSLQMFMARYKQLLPAPKCSFSEIEPVRTVKTLPSPDAREGSQGLGSRSDWRSVITETLMLNARMSNDNLLHKIGEVCYDLEQRCDNVEVPLRAVEQERDAAMLETQQVKNQNSTLGSQLQQASDTITALQLDISRLETHAEAAFIRAEELSATLDAARKDLEIQKRESQDMVASEREMARTRELDLVASITERDDQLEALQEEITDQKAETMNVQKALDEIAREKSSLLEQNASLSQDVMGVEEKLKHCQILLTRKDEDTQKLLSDKDDKEREVEALRIKLDEEVSKSNGLASALEKAEEDLQQERETVKDYRTRLSVATAKYAKQTEEISSLQMTMQAAASDAAKDLQTKEKRIHQLEKKVQQLRDERAAKAREFSEAQQHIGRLMNVMGFRAEPDSSRPPSKPSRTRPCQTTTTQQTQPAGDEFQTQPENQVRDSFGTNLSPPGSRSPKRSRERAFPGADSSSQQMMTDKRSRDSTPRPRRTPLEDTDQNSQPYSQRGTASPRSEGGASAKDRASGSLEENQLRQIDLDMDLEFSKNFLFTSTSLSPPNDHMPFSEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W247</accession>
    <name>A0A317W247_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase substrate phosphoprotein PP28 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_537352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464914.1">
        <property type="nucleotide sequence ID" value="XM_025612247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W247"/>
    <dbReference type="GeneID" id="37114390"/>
    <dbReference type="OrthoDB" id="21120at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019380">
        <property type="entry name" value="Casein_kinase_sb_PP28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039876">
        <property type="entry name" value="HAP28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22055">
        <property type="entry name" value="28 KDA HEAT- AND ACID-STABLE PHOSPHOPROTEIN PDGF-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10252">
        <property type="entry name" value="PP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Casein kinase substrate phosphoprotein PP28" evidence="2">
        <location>
            <begin position="94"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY79342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="209" mass="22932" checksum="2CF41708518E3FEA" modified="2018-10-10" version="1">MPSSSQEDASSESESDESSDEERPGPSAVSPPTVATEMTREERRAAAKAKKQAAQARRLQTAAQPGDLPPSDSEGSDKEDENDDNEEDEDLPANPNHTTKSRSQLSGTTDDAAQPEGGDLSQLSRREREAIEAQQARERYMKLHAEGKTDEARADLARLALVRERREADRLRKEAEKEEKAELAKQRAAELQVKLQAAKGKKKGGAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2E6</accession>
    <name>A0A317W2E6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_164760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464930.1">
        <property type="nucleotide sequence ID" value="XM_025605896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2E6"/>
    <dbReference type="GeneID" id="37108039"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY79358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="145" mass="17059" checksum="FB8BDF8848585AE0" modified="2018-10-10" version="1">MQTSVIRDFVRVFAPATDRKRETGGASRGVEHHRTMARPIPLPFNVMSYIEGDEQRRKPSKKKGRKRKMEMTKRKKKRKQERKRKKKGTREEKEKKRQRKNRTAQQAIASNAWNPYLTTIRDGTRRGICPGDTRPQQARKGAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2H1</accession>
    <name>A0A317W2H1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glycosyltransferase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_470555</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MNN1/MNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465376.1">
        <property type="nucleotide sequence ID" value="XM_025608342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2H1"/>
    <dbReference type="STRING" id="1450535.A0A317W2H1"/>
    <dbReference type="GeneID" id="37110485"/>
    <dbReference type="OrthoDB" id="430354at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000033">
        <property type="term" value="F:alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022751">
        <property type="entry name" value="Alpha_mannosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31392:SF1">
        <property type="entry name" value="ALPHA-1,3-MANNOSYLTRANSFERASE MNN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11051">
        <property type="entry name" value="Mannosyl_trans3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY80774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="56942" checksum="0648641AA094BB73" modified="2018-10-10" version="1">MAWDESRQLLSKNMNQFAAIRSQRSIRILIAAVGVIFILSIFWLLPSASTTKVLGFGQGHKTDSQPTAKTITTDNALITDLSHYFADYPIQKPFKERYGELGRRNRVLRDWLIQADTSSDPTKALLLNAVEEVAISQYPFLQNPQQPKSHHPLGDLRSSFDPNSAGIVIPTSDKTLRYAAHLIGSLRSVLNSTLPIQVVYAGDDDLSPTNRNHLSSLAASGPPITFLDILTIFDDTTLKLQTGGWAIKAFAALGSTFEKVILADADAVFLQPPEVLLHQEAFLHKGALLFHDRLLWKHAFEGRHEWWRDQIRRPSDEMNASLVWTEDYAEEADSGLVVLDKSRHDTLMGLLHICWQNSYEVREETTYKITYGDKESWWFGLELAGAQYEFSKHYGGIVGWENVDEQGRRGVCSFVIAHVDSKNRLLWYNGSLLKNKGQSGMENEYQVPDKWMIDAEWVKGARKQDHSCMVEGEVRSLTPEEMGVLERSIALAKMVDALVRPVEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2I5</accession>
    <name>A0A317W2I5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_537512</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465054.1">
        <property type="nucleotide sequence ID" value="XM_025612288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2I5"/>
    <dbReference type="STRING" id="1450535.A0A317W2I5"/>
    <dbReference type="GeneID" id="37114431"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="148"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY79482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="576" mass="63309" checksum="6BAEE3C0E376DF04" modified="2018-10-10" version="1">MRSLISVPRGFPAHPRALHCRPRVIAQRQFFPLRRAVRWNSSKKENRDNGSEGHRNNAHTEFSGNSSGSWTSGGTLIASALAAGVGYAYAVTSRPSQPQNLKEPQYGSAKDFEKAIAELRATLGDDTISTDEDDLQQHGFSEWSSVNADRLPVAIAYPTKTDDVAQIAKICHKYKMPMVPYSGGSSLEANFSAPYGGLTIDFAMMNKILELHESDLDVVVQPSIQWMDLNEKIKDSGLFFPVDPGPSAMIGGMIGTNCSGTNAVRYGTMKDWVINLTVVLADGRIIKTRRRPRKTSAGYNLTGMFVGSEGTLGLVTEATLKLTPIPEQTRVGVVTFPTIRDAASTAMQLVRKGIQVQCMEILDEVQMDVINRAGGTGRTWKTLPTLFFKFSGTKAGVADSINLTKTLAKGNHASSFEFARDEREAHDLWSARKQSLWSMLALRERGAEVWSTDVSVPISRLPDIIEISKKELDGLGIFASILGHIGDGNFHASILYDRTNPEERERVEKVVYDMVDRALEMEGSCTGEHGVGLGKKSSLKKELGPDTIGIMRSIKKSLDPHWLLNPGKIFDYENEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4C9</accession>
    <name>A0A317W4C9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative short chain oxidoreductase/dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_537345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465330.1">
        <property type="nucleotide sequence ID" value="XM_025612245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4C9"/>
    <dbReference type="STRING" id="1450535.A0A317W4C9"/>
    <dbReference type="GeneID" id="37114388"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY80471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="285" mass="30183" checksum="1597937E532F73F5" modified="2018-10-10" version="1">MSQTWLITGASSGLGTASPSPPSKPATKSSHSPQPHHRRLSNPQIAQLGGIWIPLDVTHPDTATHVSDAITHQAGGVIDVVVNNAGYSLLGSIEDMSEAEIQTQFSTNVFGPVRVLKGALPFMRKKRAGTVVNISSSAGVDGAPACAMYAGSKFAVEGMSESLSKELQPFGIRVVLVEPGYFRTKFFAAFVAPEAGLTEDYIGTPVEAALKLIKAKDGSQKGDPVKAAQRILEVVTGTGMGTDTEGFLRVPLGQDCYNRFQAKCDTLQANLVRMKEIAYSTGFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4E7</accession>
    <name>A0A317W4E7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_496446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465497.1">
        <property type="nucleotide sequence ID" value="XM_025609292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4E7"/>
    <dbReference type="STRING" id="1450535.A0A317W4E7"/>
    <dbReference type="GeneID" id="37111435"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016238223" evidence="3">
        <location>
            <begin position="22"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="123"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY80895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="568" mass="62824" checksum="6FCBB93F3DCFBFCC" modified="2018-10-10" version="1">MFLHGLLLWTSLVSLLALGNAAVPIYRRCTSCRCFPGEACWPSLAEWASFNKSLDGRLIPTVPLGKPCHAPFYREDECDYLRDQWTEPEIHYESSSSIMAPWFANGSCDPFHPIAQPCLMGNYIAYAVNVSRPTHISQALAFATKHNLRVVVRNTGHDYNGKSTGAGALGIWTHHLKDIDIRDYHDAHYTGKAIKLGAGVQGMEAYEAADAHGFQVVGGECPTVGIAGGYSQGGGHSALASRYGLAADQVLEWEVIDGKGNFITATRDNKYRDLYWALSGGGGGTYGVVWSMTSKLHTSTPTSGLNLTFTNANISQDTFYEAVALYHSILPSIVDVGAMSIWFFTNTSFYISPLTGPGIPVQELEALVQPFRDGLEKMGIAYTFYSAQFPTYLSEFDGMMPDIPVGEAQYGGWLIPRSVVQNNNTALTQAYRQITEDGATFIGVGLNVSKALVGDVYNAVLPAWRDALIDTTLTTPWKWDDRQAMLVEQYKMTYEYLPLLERLAPNSGAYMNEGDFRQPNFQRAFYGVNYPRLRQIKAKYDPNDIFYAQTAVGSDEWTVFADGRLCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4F6</accession>
    <name>A0A317W4F6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_558270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465471.1">
        <property type="nucleotide sequence ID" value="XM_025613997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4F6"/>
    <dbReference type="STRING" id="1450535.A0A317W4F6"/>
    <dbReference type="GeneID" id="37116140"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF2">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016194003" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY80869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="558" mass="61280" checksum="1E722201F5C84907" modified="2018-10-10" version="1">MGLKFGLAVGASLLTVASAQFKCSLPAGDICAYENATTYQAVNAPNCTTRGLQAFVNRLPGLNGSALTVPYAFYIDSNATLEEFTDYVGASAFTTNIPAVCAFRVNGTNADGASWGLGALLPTHFNGSMMMAAPDSGLSWGVASAGLKYAFATFATNSGHDEPDYVPGWETPEGLIDWSHRALHLSTLTAKAIVKAWYNVEPTYSYITGCGEGGRQIMKSIQTYPDDYDGAMAGAPTWWMTHQAFYSVKQETLGAPGSKSSIPESLYSVIGEEVLRQCDPQDGLTDSIISRPQGCFFNAEALACNSTHTTDCLTPPQLDTVQKIYSDWVTFDQDLIYPRAWYGSEPTWNSTFGRSSGSWYIENVLGFKNFTAQDLTYELIAEADARDSVHANADEFDLSPFFNRGGKFFHWHGMSDSFVSPGASVYYHNQATYAALEKGIDIDQHYQLYLIPGLEHCTGTPDCMAALWYLAGPYQAGNFFNFTPANVVDNYVHDSFLTLISWVEGSHAPSYMVTTDFKDNVDPTTLLDNRKICPYPRQANWTQTGVSTHEDYWDCIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5A4</accession>
    <name>A0A317W5A4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_148628</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465812.1">
        <property type="nucleotide sequence ID" value="XM_025605787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5A4"/>
    <dbReference type="STRING" id="1450535.A0A317W5A4"/>
    <dbReference type="GeneID" id="37107930"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="217"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY81744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="653" mass="72072" checksum="CCF224EFF547C04D" modified="2018-10-10" version="1">MGDHTPGGTGTTTTRIRAEEANTSGDDRTTQPPIEPGEAESAMGIARKICELGSQHLDEQTTSAIPGYSATNSAPLVQESVADHRRPISSIFGQPFPSIDLVYTLLDEYFDAVHWFSLVVHEPKFRRRLHSIADGCAHPAQRPFLLLLAVMLGMAAWYRSRRSGPDAAQDWGQWSSNLLKLAESNLMDMMDQPSVLAAQTCILIGSHNLYHGRPNLSFTLLGATIKMAHAIGLHREPPQGDVDEIEERKRVWWTIYTWDRFASITYGTPLGINDKDCNLSMPADVFEDPSFGAPRPDHREPICYSPYQRELNRLYLIASPALETIFGSRTSQTSQELVGDTFVTLVKQATENLQVWRRSLPTHLVLDLRYDFQMDGRQSSKAHALQALALQLTYDNILIVLHRPLIARQVDHLSTNKLSPGGSEVDPTAFLSPPLSSETPSRSPFEATLVKAQTASSEFWMKAAVRTSRVTEQPVLAQLATDSHLVAFLAISLFNAAIVLAVMALSDPLSDTAQEVKRTMTRILRLQDLLGKRSALSKQSTHVLKKVITMLLRRESAAMLAPLTGTAAFIDYDSNKQAPPETYPMSVEDTLRLPLDAPLDLSEPVSDSQGGSDVIRTHRLNDSLTSVQYCKHLFPGGLAGQLIATDSSNGSWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5D0</accession>
    <name>A0A317W5D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_520745</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465403.1">
        <property type="nucleotide sequence ID" value="XM_025610125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5D0"/>
    <dbReference type="STRING" id="1450535.A0A317W5D0"/>
    <dbReference type="GeneID" id="37112268"/>
    <dbReference type="OrthoDB" id="9985472at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY80801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14170" checksum="E145B922C6A2E8CF" modified="2018-10-10" version="1">MSYTGHCICKNIQVSLAQQPASSLRCHCRNCARSGGGSSLNYVLDSDEVTLSDPHSLLKSFDDTDTLSGNVVLRQFCSQCGSPFATKSPQFPGKTHLKASLFDVIARPEMEVFTDRRQGWVGEVEGARQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6M7</accession>
    <name>A0A317W6M7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_520915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465519.1">
        <property type="nucleotide sequence ID" value="XM_025610131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6M7"/>
    <dbReference type="GeneID" id="37112274"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF39">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY80917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="573" mass="62102" checksum="E51277FCDCC50B3C" modified="2018-10-10" version="1">MRTDEHNPLNRRHSSTLHYQTFDTPPPKSRGRPNSGQSGSSGDDSQYQPTDSHHGPGHGSPLPKKQMAVLAMISLCEQTAFNSVSPYLPDMASSFPEVEPNMVGVYVGAIATSFAIAQLVTNYFWGWLSDRVGRKPVILLGTILTAACFVAFGFCTTLYQAIVVQALMGAVNGNQGLVSTCLGEITDRSNQSKAFTYLPVLYGIGGITGPLLGGLLIFEQNPFNKSQRNPYPYLAPNLLSAGILVMDFVLSIFFLEESLEDADTIPNFKQRVRAIFAWLWEWTSSAKSASRMKPPHATHYRHLRTQSDESQDHDSELDSASEVSETRPAHHESLTRSEIFNRDTVLLLLTYLIFALCNVSFNSLFPIFSQAPPPQGRGLTPSEIGLAQGFSGFVTIIFQICIFGRLRDKMGNRWSYRAGLFGFVLSFILMPFVGYKSDGTGSGVSGKTALVAFELCFALLVKTVASVGGLTSALLLITNSAPDHAVLGSLNGLAQTLSAAGRAVGPFLSGSLFSLASRLKHKGEAMPFGVFAAVSFVGFILSFGIRGRSLEADDWESDSDDSDKSDDDEPSGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W886</accession>
    <name>A0A317W886_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_157352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465209.1">
        <property type="nucleotide sequence ID" value="XM_025605846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W886"/>
    <dbReference type="STRING" id="1450535.A0A317W886"/>
    <dbReference type="GeneID" id="37107989"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23837">
        <property type="entry name" value="UBCc_UBE2O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000094">
        <property type="entry name" value="Probable ubiquitin-conjugating enzyme E2 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF15">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="748"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="633"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="642"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY80350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112345" checksum="2F3E154144281271" modified="2018-10-10" version="1">MPTDLIYQPPKGYVFVGFSEFAEGYALIHEDDLELIDRPVEIGETVKRHPDDTMAGMVINASATCTLEPIASRTYDPSIGYFDSLEFTESSRGYGNEAPRPPLLHDVPISELVNHEEFSEGDYIIHRQKFGIIRHVERDAILRVSNMPVWILNPDVLEVPVTFDDKGLIWMPKDQPSREINAINADMRFLEYDYVYPGQCVVTPRTNMRKMNGDSLIGMDVDPHGYVLATPATEYQVEWLCMNVFSLGMPYTGDRMELLRASALNGNAMKCDFGKVPTGGAVKSDVWLKVGDRARFRDPAGAAQKFPSFQPIPLDESFGYDLNMFRIISTKTEVTVQWQDGSITTGNSRSLRRFYGFDDEIGPGNIVALKDGLEEIQRPPLDNMPSFSKRLPGHKRETMRARTVGVVQTVDSRERVATVRWYKDPDVELLHGGQILRPCSSLGELGDTISQVSRYELDMFAGLGRLPGDIVLLAPDTIHESSLQVHDMEGSGMSGPCNFSYTSSLSFFQMYTYLEAMRMEMLDSEWFKKTTRIDTTPLPSRYSLHQWALNASFHTDFIGQIVSIDTTGAITVRMAGSTNCRDVRVPFERIMMVIDEGEANPATFPSPAELSQLEAASLFDLPEDMQLTTTYEYEGGERLDDGGEDQWMTDDTDDTDDSNVQSADLPGQDHIAPDVAEIRLPENTNDEMGGDDIDQEMKDVTDDTDPMAHAADKQPTLSTSPPGFVVLEGLPPRDHHFISEEATDNSGLRIKRIRNEFGILSKSLPPGIFVRTWESRMDLLRVLIIGPEGTPYEYVPIVIDMHFSNDFPNQPPAAFFHSWTNGQGRINPNLYEDGKICLSILGTWPTRNPEENWSPTKSTVLQILVSIMGLVLVKDPFYNEAGYEALAAEGDRRVESTQYTEKTFLMTRKFIKHVLEHPVAGMEDVVAWNYLPNPADPGNGNRPIVLRRAIEAALAMIEHYNSSTSGDAGSASAFVSRLSLGAVVMLRKHVTDLEKIEATAIGSGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8P0</accession>
    <name>A0A317W8P0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_536867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465680.1">
        <property type="nucleotide sequence ID" value="XM_025612135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8P0"/>
    <dbReference type="STRING" id="1450535.A0A317W8P0"/>
    <dbReference type="GeneID" id="37114278"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF72">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY81612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="681" mass="77693" checksum="87FE16688E1F0441" modified="2018-10-10" version="1">MPDEPRIWQHSRLVDEAEVKKSGCFTTLPVRVSLYDDVADNTAKHGNRVWHWFVGDGLDTATSETSSPVGNLCSFFYPECAPGRVEVMAHIHELLFIQRDILDDGGCKDEDSTAAKDKKSPSGATGATRIEQRLSIYFLRAVQIDHSAGTDILETYKRSWRPDADAQCPSGIDDFNNLFLMRRSKARFNLYYFLLAFSQEFRLSALDWATMNDLLHLFELIMLHTGDLHAWEKDKQSGSGWARALNFIPFYMRTEKLTEDQAMEKMRRTILDYEKRFITAREQLYNRGSLSFHLRRWAEVCGAAIAGYHYWCANCPRFNRIDGRFDASDSQSAVVETPSSNETESLVQGETVLPYLHARPNADSEPADNPPRNGNLLDDSALQGPVNYIQSLSSKKTLTKLMEAFNIWLHIPEEQLSILSQVVEDLHNASLILDDIQDESELRRGNAATHLIYGAPQSINSATYMITRVSQLLHTSQNASLPIYFEELENLFIGQSWDLHWKFHKKCPSENEYFEMVDRKTGALFLMLLRLMQASSPISTSFDITHFCQLMGRWYQVRDDYMNLQSADYSNLKGFCEDLDEGKFSYPVIRCCNTNDSARDIILGAFQTHRGTSEKLARATKLQILRLIDSTGALDHTWKMVRDLHREIDAEIDVLEKKLGENQMLRAMIKALGKVPAPDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WA58</accession>
    <name>A0A317WA58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAB1 binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_469681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466038.1">
        <property type="nucleotide sequence ID" value="XM_025608298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WA58"/>
    <dbReference type="STRING" id="1450535.A0A317WA58"/>
    <dbReference type="GeneID" id="37110441"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025852">
        <property type="entry name" value="SM_dom_ATX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14438">
        <property type="entry name" value="SM-ATX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="265"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="620"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="928"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1061" mass="113834" checksum="AB222A2F4D1AC4A3" modified="2018-10-10" version="1">MASTVNSMPAANNASGNAANAQNPGARPSLRSSANPKASEGGRRQSGSPLEGGQRRSNSQKAWSHGTNPITQRVSYAQQNGNMSHKQSASPRATSKESNTPDNHAHDRLVFLLTSFIGLNATITTRNGEKFTGIFSSSSLEPSDSSFVLKMVQRPPKSDQNKANGASEASSPFMGSAPDHSMSFDVKDVVDISVPNVTTADVTAKSSNGTPVGFRTDTDISGNLAIRERTLKRWEPAADTDVDLSLETTNNQTGWDQFEANARLFGATSSYDENIYTTRIDRSDPTYKQKEADAARIAREIEGTTADNAHVREERGLVSMDDVDEEAKYSGVRRDEKDFPPLVSGQPNKYTPPARRQNAAQSAAMATGATASAIKQAPAAPKEAAAAGPPKENGQVQAQTAPTSVATSSSADAEQKPALSKTPTGATGSAPGNATSNVEAEVLDSFRQFAHSEKAKLQERRRNQATYDRTIKLNELMRFSKSFKLATPVPKDLVPILAKDPHKQEEIIQRAQQHAEEKIVPKASASTEQKPAARVSGASRQESGTVLPATQSDRSNYPRGRQMFPPTGPHAGPGGRLPQQAVHQGRQATGMLGHRLADNIQQRKGAAVGAVPAPLPIHDVRIPPAGPAGDQPAVTSPNKSQTPTSALSTKFNVRALEFKPNPAASTFTPGASSTSSPFTRGRSVSRATSPSLFFGAKKPRPISERPSLNNQFNPIKRMKKEGTEQGDKGYTFNGGIPPAYKTPPTWDVSAGNEEKDYLQMFKSPASVPAISPQSRSASNPQLPHPPQMPFQFPQTTPGIPPTTGPPHGPHLHPQQHHSSGPPHFDDPHRMQMSASTSQMFPSPRLQHGYPSPMAPHAQLAFGQGMPQFFVNQGAPQPAHMRHYPGGPQFVNPQTAMGAPMMVQQPSSGPYMGVPQGVAPYTPQMQMYSPNPSHAYPQHVPPPQPHSGYPSPSRGAPMMMHQNSQPGQPPQPVMFMSPGQHGQPVYPAQQPAHMPPVRGNYPQQQPHFQSSPHQVHHYPPHQHRTPSSGYNQMPQIPPQMAAQPAAAGASGPQPQEAADEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCQ7</accession>
    <name>A0A317WCQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_468940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466163.1">
        <property type="nucleotide sequence ID" value="XM_025608280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WCQ7"/>
    <dbReference type="STRING" id="1450535.A0A317WCQ7"/>
    <dbReference type="GeneID" id="37110423"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29863" checksum="223D50A1D7B3677C" modified="2018-10-10" version="1">MTAKPSEDQGSKDHDKIERRKRQNRINQRTYHDGHDVSAAKPHASLDRFSDKPLVHPRTDSLDIIACYLAPRGACERAVAFRKYAFQSYITGSPKTDHLLTLTKINVHRALVENMAALGMDMNWMNADAVSPFCTSQPWPPTSNTIIPAHLRPTDIQCTVPHHPWLDFFPHPRMRDQLIAAGDGFDDEQLCTDIMGFWSDEKDSPGLVIWGNPWEVGNWELSEGFLRKWGWAVRGCTELIRSTNYWRAMRGEKRLSMHALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD88</accession>
    <name>A0A317WD88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_599396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466363.1">
        <property type="nucleotide sequence ID" value="XM_025616317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD88"/>
    <dbReference type="STRING" id="1450535.A0A317WD88"/>
    <dbReference type="GeneID" id="37118460"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF1">
        <property type="entry name" value="AMINE OXIDASE [FLAVIN-CONTAINING] B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="48"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="67"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY83895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="493" mass="54410" checksum="FE19271B60CA3976" modified="2018-10-10" version="1">MTSRDGYHWTPEVGLTHGVPSLGVISPPTNIKNTDGPWDVIVIGGGYCGLTATRDLTVAGFKTLLLEARDRIGGRSWSSNIDGYPYEVYSPPIPTYQPNPNLIPTPDGRHLGPLTPSALNHFQLRTSPNTSTPTSTYMTHEAEDELLRTALHKLTNVDGANGRIILPFPHDMFHVPEFQKYDNMSYADRINQIQDDLTPNERASLEAFILLCSGGKLENSSFGEFLHWWGISGYTYQGCMDCLISYKFRDGQSNFARQFWNEAISTGRLGYVFDCPVARVSDSDDGVRVTARDGRVYAAKRVICTIPLNVLSGVQFSPPLSETRALAARNGHVNMCTKVHAEVDNKAMRSWTGITYPLNKLCYAIGDGTTPAGNTHLVCFGTDANPIQPEEDVRETLRAVGELAPGEFGVKRLVFHNWVKDEFAKGAWFFSRPGMLGDCLEGLRERSGGVVFANSDWALGWRSFIDGAIEEGTRAARVVVEELRPGRGVRACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDI9</accession>
    <name>A0A317WDI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_566612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466399.1">
        <property type="nucleotide sequence ID" value="XM_025614571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDI9"/>
    <dbReference type="STRING" id="1450535.A0A317WDI9"/>
    <dbReference type="GeneID" id="37116714"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY84474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="201" mass="21250" checksum="9747FD573C3CD064" modified="2018-10-10" version="1">MPPKAPKGEYIETDTGNKISRRSLIHGTQHIILGGKTVIQADAVIRGDLYRSSSSSTPTDPQQAAAATPNSPSVAITVGRYSYISRQAILRPPSRLHRGVYSFYPLKIGDHVFVGERAVVEAATVGNHVHIGKDAVVGSMAILKDFAYVLDGAVVAPGMVVPSWCVVGGAPARIVGEVGEGYGVEGAEGGMARERYRLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDQ3</accession>
    <name>A0A317WDQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_105708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466521.1">
        <property type="nucleotide sequence ID" value="XM_025605483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDQ3"/>
    <dbReference type="GeneID" id="37107626"/>
    <dbReference type="OrthoDB" id="5394254at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY84596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="344" mass="37273" checksum="4AE16935AB18FABD" modified="2018-10-10" version="1">MSPRKKEVLSAVTTTADSSADTAEKSTRKLRQKTRVERIHPAVRFSLAVFSSLALSSTLFTLTTGITLGELGSVSKHLETWWEVGGLMVWKAVEVGLAWILGFDGRDVLSFIFLTHLPTYSLLSTFYGLRPTTTLTSYFITLASTTIPFVLLRSPTPIHSQTTTIPNRSILQDRPTTIYTTIGATAIFTVTLYLSYATTWLPTKLVTHFQDLPDISTVHAGPAGLPVLFLTLLPAGLAARDFLFASSTGASPSKDTKKNASPEGEYLACTVYRKTWGALTKKTQVLISRTGLLASMLFVNTVIQVAGTVNRVDVEGAMAWGTVWSVAALVTGAMFGWIEAVDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDR3</accession>
    <name>A0A317WDR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_547194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466531.1">
        <property type="nucleotide sequence ID" value="XM_025613318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDR3"/>
    <dbReference type="GeneID" id="37115461"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16462" checksum="6AA9E9AC2E7E0191" modified="2018-10-10" version="1">MKESAARPEEKASRRSAIAIPRTMSLLVSSYHLQPRPRGWRGMTMAATKERGRHDTSTPSKQVKLHSLGADGAPVHPSALLSFPLEDNNKEEEEGEPPITGNLPSRLGRREARRPGNWCPLSSEWTVASSHTPTRDGNTKRCGSWKVAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE15</accession>
    <name>A0A317WE15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytosolic regulator pianissimo</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_625149</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466548.1">
        <property type="nucleotide sequence ID" value="XM_025617259.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WE15"/>
    <dbReference type="GeneID" id="37119402"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11627">
        <property type="entry name" value="HR1_Ste20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000009">
        <property type="entry name" value="Cytosolic regulator Pianissimo, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="3">
        <location>
            <begin position="114"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="5">
        <location>
            <begin position="247"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="4">
        <location>
            <begin position="691"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY84623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1313" mass="146253" checksum="733F42458F4961C9" modified="2018-10-10" version="1">MASGHNSAFSATSVQPRALGDGRSYNSLDDGPADGSWAEAASRTGRNARSESGGSATIGLRGGSLAPSSGAPGSFSSELKSMKTSRSTTPRPDGGLARRPSSFLEHDDLSGTEERQAVIRDKIAKEMKIKTGTENMLEALLAKNPKHTKEQRLRVESELSSSNRKLAELQHELEEEMLRAQAPSTPPRSRLSSLFQSGSMRSPTRNNVTLDDHQVQEGEAEMESPTYVLAETLQALEIEGMSPDYYVERANSLVELFKRHPTLKYDLEWSVFGLRVQIMLLSDSKEAVAAGYRLTRYAIADRKSLQIIRSLHTDELVILSLVKESKASIEREQALKFVRAFLDVKDGVREISRAVVRTIVSIAEHYEDRLRNISIMTLAEILVKDPALIAYSGGFATLHDALAEGTFGASESLIASFLHVLDTPHSRKHLRGGCELEAVLAPFTDSLSDSVRNGRLKSSARAISAMLKTWPGLIVLARNGAKPLQSLLDSLHYPDPQARDLIMELLFDALRIKPPSWSSSFLAGRRLTTYGRVANLRAETDPKQARGFFDDDGNRFDLTAHFSTLILATLVDAGLSKALSDLIEDETDLSLRRKATLLLTEVLKLAHHSLPQHISAKLQVLPHLLPAAIQFDVENHDVSTSTIYQIESINRTLARSVGGVSNGAGRYNVDVDISASLLSGDQGKEKMNPAMDETQFRNAILETHVLNTVNYLKWKWDLIHRIVEGPLTNPKRLEEAIKGSKFMKRLMGFYRPFKYRFSMLPNTKPNQRYVRTGCALMRTLVQLPEGTKYLAENKFLRQVAECLAQVDRMSGLTSSSPLFSREQMANTSSGGYFALLGVLSGDSNGLAMMERWHMLNMFYHIIELRDRDDLIQTLLGNMDYAQESHLRVILSKALTTGSKEIRIFATKLLRKYAVGNVPLSSQSPTGSADWVVKLLVTQLYDPDVSVCQVAVKILEEACNQRHYLEFVVKCRPSLDHLGEIGAPLLLRFLSTSVGYHYLDGLDYITQEMDDWFLGRNDAYVGLVEAALSRAYVDQPRRSSFVPEDLVDLQDIGLVPPHFYRELARTAEGCKLLEQSGHFNEFAWTIRDFQLDEEDTEALLKVKGCLWAVGNVGSMELGAPFLEPDIVQHIVKIAESAEVLTMRGTAFFVLGLISRSRHGLKVLRDFGWDSALDHKGNSLGLSLPTDFNKLFLVDFPSHSRNPESKRTSQEKFKGAAMDPDPANQKILKLIVDMGNTVLSKRAAADLHSMKSKQPDRFHQPHLFRKTLSILESHHFRLPARRFALDLFDKSVMRRIVLEDDSDSDSEASSSQVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH30</accession>
    <name>A0A317WH30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_493824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466803.1">
        <property type="nucleotide sequence ID" value="XM_025609210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH30"/>
    <dbReference type="STRING" id="1450535.A0A317WH30"/>
    <dbReference type="GeneID" id="37111353"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY85786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="462" mass="50710" checksum="AEBD5D81449540B0" modified="2018-10-10" version="1">MASKSAATNTMLPPAKPITPFWRTELDQLDDVRTTPDLPPQSDIVIIGAGYSGVTLAYYLLKQLADQGDKTTTVTLLEARQICSGATGRNGGHLRPDIYGHIPTYITRYGLDAGVEIADFEYAHIQALKDLLREENIDCDLNITRNMNAYLDDVSAENARKAYEMLLARGVELAKDLHYTSQRDAEGVSGIKGAKACISYTSGTLWPYKFILGLLNKIIHSTQLNVQTHTPVTSITTEGETHTIHTPRGSLRAGKIAYATNAYTAGLLPEYSDNIVPCRGICCHITVPEGKTAPFLPYSYAIGYGSEVVNGGSYLITRPDGSIIVGGAQYTFKRDLAQWYGVVDDTTLIESAKNYYDGYMQRTFRGWEDSGAYVKEIWTGVMGYSYDSHPHIGQVPNKPGQYICAGFNGHGMPVILLSAKELAGMIQTGKSFEETRMPRMFKTSEERIEKARTGPKGGDILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHB0</accession>
    <name>A0A317WHB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_518414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466881.1">
        <property type="nucleotide sequence ID" value="XM_025610033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHB0"/>
    <dbReference type="STRING" id="1450535.A0A317WHB0"/>
    <dbReference type="GeneID" id="37112176"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF24">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="143"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY85864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="403" mass="45118" checksum="E66573CD092756FA" modified="2018-10-10" version="1">MSDLRMHPAPFQYSAEQWARYCLENGTSGSYPSNRVDNPKMHPDNLYGPVEEWTRYCIDNGIRLPIPSFPENAILPDERIQQDINKAWEKSSRQTLEADGLEYRVDISQCAIQREGDPDDKFTIRAYRPKNTKYHGVPLPLYVHFHGGGFLAGNLDTEDATCVRMVAQLEEADCPVIVISVGYRVTSEAPHPAAYQDAWDAYEYLERNTDIMFGGDVTHVIVGGVDAGAALALHLAVFSNLVFDEGMQRGLTIIGLMLCSPRLPYMDAEGMGISGEQGIDAPIWPQALHLMFCRKLAIYDVQSPEYVLNSLTKYEGLPKTGVLITGQSLLRDQGLKLRDRLEACGVPVQCRIYPGLPHDFRRINELPTCVKWDEDIVEGIRWFLGLGPGWDSPARGRDPYPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHX4</accession>
    <name>A0A317WHX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_557645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466268.1">
        <property type="nucleotide sequence ID" value="XM_025613940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHX4"/>
    <dbReference type="STRING" id="1450535.A0A317WHX4"/>
    <dbReference type="GeneID" id="37116083"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="331" mass="36573" checksum="1684302EE633ECB3" modified="2018-10-10" version="1">MVMLRLTVEQYRKLPVLVDEKTCIGKTFIITGGNSGLGLETARHLVAASAECVVLAVRNLQAGEAAKNDIEKTTGRRGVVQVRHIDMSTYASVQSFVKRITDELDRIDGFICNAGLMIDAWSQCEGMETSMFVNVINTVFLGALMMPKLKECAERFNIKPTLVFIVSVLGYTAKSELEKSRNNVIFDGLNDQKRANMDSRYALTKLVAECAARQLAAQCPVERTGVVITMVAPGLCTTGLGRDARTFTKVMHEAVRAMMARTAEEGSRTILHGLVVGEQGHGKLLSGCKIKEYWVPTWLTNEEGQTLQRRIWDELVSRLELVQPGCISQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJY3</accession>
    <name>A0A317WJY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1665 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_535535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466966.1">
        <property type="nucleotide sequence ID" value="XM_025611806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJY3"/>
    <dbReference type="STRING" id="1450535.A0A317WJY3"/>
    <dbReference type="GeneID" id="37113949"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="154"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY86375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="289" mass="32030" checksum="2E1D3927038E735D" modified="2018-10-10" version="1">MPPHMKKRKVLESLQAGPKKKFRKQRTYHSSSEESEDDEPTDFKAVNLADSDDEEVQVKKLKKQTKSIGASTKTKVEKKEESSDNEEADDDDDEDVEVESDLKGSDVSDDEDGADSDTSMPTTTGRRAVSKRNDPSAFSTSIAKILSTKLPTSVRDDPVLSRSKDAAQKSTDIAEEKLDRQARAKMRAEKKEELDRGRIRDVMGLQRGQAGAVAEEEKRLRKIAQRGVVKLFNAVRAAQVRGEEAAKAERKKGTIGISEREKAVNEVSKQGFLDLISGKKGKPLKIEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLS3</accession>
    <name>A0A317WLS3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_75803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467551.1">
        <property type="nucleotide sequence ID" value="XM_025617649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLS3"/>
    <dbReference type="STRING" id="1450535.A0A317WLS3"/>
    <dbReference type="GeneID" id="37119792"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF15">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD16-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY87343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="347" mass="39123" checksum="A00A76A5B3AFA996" modified="2018-10-10" version="1">MASNEMEYVRLGNSGLKISKVILGTMSYGTKQWQDWVLDEEDALPLIEHAYKRGINTWDTADVYSHGRSEEIVGKALKKFSIPRNRVVILTKCFFGVDDQGGFPSIAASGRNEGEFVNRVGLSRKHIFDAVDASVARLGTYIDVLQIHRLDRDTPREEIMRALNDVIESGKVRYIGASSMAAWEFQTLQNIAARNGWHQFICMQNYHNLIAREEEREMIPYCLDTGVGLIPWSPMARGVLARPWGSRSTVRESTDGALKLLIRSRETESDKAIVDRVEEVAKKKGASMAQVAIAWSMSHPNENPILGLNSKERIDEAVASIKVKLTDEEIKYLEEPYIPKTHSALER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMM5</accession>
    <name>A0A317WMM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GET complex, subunit GET2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_535445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467533.1">
        <property type="nucleotide sequence ID" value="XM_025611785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMM5"/>
    <dbReference type="STRING" id="1450535.A0A317WMM5"/>
    <dbReference type="GeneID" id="37113928"/>
    <dbReference type="OrthoDB" id="5393181at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY87325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30533" checksum="84D7072FF2E87092" modified="2018-10-10" version="1" fragment="single">MSSPAEESPAQRAARLRRERREAKIKGDGAARLDKITSLSGRTPASLREETSPSPSPTPQPPVTASPAPEPRATTAPAPQPVFPDQQQSPESLQAQQELFRALLRQSAPPQGTTEGQEVAGEEDPTMKLLSSLMNGETNLNENALPGGQSPADLLTGLGVPPFVASMLGEATRQKTDAEKREIFVWKVLHVVFSVLIGIYLLVLIGSSVATYGSQPPPPATARNPFVFFTTGEVVLSVARIMMRGGKGGLGMWLQLAKDISRDGSLVLFLFGMANWWHREWMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMT4</accession>
    <name>A0A317WMT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative choline dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_597318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467183.1">
        <property type="nucleotide sequence ID" value="XM_025616270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMT4"/>
    <dbReference type="STRING" id="1450535.A0A317WMT4"/>
    <dbReference type="GeneID" id="37118413"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016299846" evidence="4">
        <location>
            <begin position="21"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="592"/>
            <end position="593"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY86592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="611" mass="65866" checksum="754DAC19B2781008" modified="2018-10-10" version="1">MTAFKFLAALAAFGLRVASAVPHNLSSVTFDYIVVGAGSAGLTVASRLSEDPSVSVAIVEAGTWSELVTGNQSQIPGHDFYYNGKSPSDTNPKVEWGFVTTPQAGVNGQSIHYSRGKSLGGCTNLNYMGYTQATEGSLQLWADTVGDASYAYNASSYYYRKSLNFTPANTQLRLANATTEAPNSISTGGPLHITFPSWAQSFSTWISIAMNAMGIRSTEPFTNGHLNGSSWVALTIDPTTGHRASAATTFLARAANRLNLHIFDLSLAERILFDPHRVARAVKITSLTNTTQPTNITTTLHARREIILSAGAFQSPQLLLVSGVGPASLLKQHNIPLVADRPGVGQNMSDHPFFGIAYRVNVETSSALQYGDANALATAEFNANGTGPLASPGGDFAGYEKLPAPLRTSFSNTTRADLSRLPSDWPEVQYLTLPDFVGDFESRTASAPTDGYQYATLLATLIAPSSRGNVSISSSRMSDPPLINPNWLTTEQDVEMVVAAFKRLRQILEAPVMKNVTIGEEYYPGSEVSTDEEIFAQIQKSFNTMYHASTSCRMGRKEDPWAVVDNRARVFGVEGLRVVDASAFPFLPPGLPQATIYMLAEKIADDIKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WR58</accession>
    <name>A0A317WR58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_491532</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468268.1">
        <property type="nucleotide sequence ID" value="XM_025609157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WR58"/>
    <dbReference type="STRING" id="1450535.A0A317WR58"/>
    <dbReference type="GeneID" id="37111300"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000489">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="35"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY88906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="528" mass="56779" checksum="A00C735BF8670F61" modified="2018-10-10" version="1" fragment="single">MMDSRKSISMDRVEEAPLETENHQFYPVGPRLIMVTISLMLAVFCVALDNTILSVAIPKITDDFKALNDIGWYASSYLLTTCAFQLLYGKLYTLFNIKAVFLVALFIFELGSLICGVSPTSTTLIVGRAIAGLGSAGIFNGALVTIAHTVALEKRPLFFGMIGGMYGIASVAGPLMGGAFTDHVNWRWCFYINLPIGGVTAVGLIFLLRLPTRQNVRPQGFWNIVAGLDPIGTALFVPAIICILLALQWGGVDYAWSNGRIIALFVLFAILLISFVVVQLMMNEKATVPRRIASQRTIAFASLFALCIGGSFFIMIYYIPIWFQAIRAADAVRSGIDSLPMILANVVGIVLSGALTTSTGYFTHWFFLSSIIMSIGAGLLTLLTVDASQAKWAGFLFLYGIGVGFGFQQGGIAAQAVLPLSDVSIGTATIMFIQMLGGSLFVSVAQNIFTKHLVANLAALHIPGLDPATVASAGATSFRAVVSEEYLPQVLVAYNSALIKIFQLSMILSCLSILGAVGIEWKNVKGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRW7</accession>
    <name>A0A317WRW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclophilin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_624180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467835.1">
        <property type="nucleotide sequence ID" value="XM_025617201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRW7"/>
    <dbReference type="STRING" id="1450535.A0A317WRW7"/>
    <dbReference type="GeneID" id="37119344"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="222"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="530" mass="57874" checksum="8B0049E79A934968" modified="2018-10-10" version="1">MSTHYNTEPTATASATLHTTLGPLHIALFANQTPLTCRNFLQHISDNYYTGTIFHRIIPNFILQGGDPTGTGSGGTSIYEDPLFEYDATARDPNEKVVLRDELHSRLRFNRRGLVGMAKSEDGTYGSQFFITLGDVSRELNGQCTLFGRIEGESIYNVLKIAEGEVVEGTERPVYPIRTGKKKGKKGGKTLLSFGDDEEGEEMPVRAAKPKYNAALVTDTGAGIGNGVGDDAPVEKKPKKKEVRKTSPPRRRSPTPPPVVDRPKSPDPAMQLPLPDPESPERPPSPQPTQKSRLDRTNAEIESLKASMRRTVATETETGGKKSALKAMIPQTAIRGRKRPAPGTSASSSATNGITGFSSSSSDNAALKMFNAFKAKLEGADANPAPKPTTTTTTTKETPQREDDNEDEESQLCDLHFIANCQSCKSWSDNTADTAGEGPADDTDLGWLTHQLHFGKDTLGKDLKWKKEHPDDLDSLMVIDPREKEREIVASGSGSGSGSGSGKRRGLERDRERDRKRGRVGDLEWERSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT36</accession>
    <name>A0A317WT36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TNT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_463798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468410.1">
        <property type="nucleotide sequence ID" value="XM_025608037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT36"/>
    <dbReference type="GeneID" id="37110180"/>
    <dbReference type="OrthoDB" id="2923349at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050135">
        <property type="term" value="F:NADP+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053024">
        <property type="entry name" value="Fungal_surface_NADase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025331">
        <property type="entry name" value="TNT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42059:SF1">
        <property type="entry name" value="TNT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14021">
        <property type="entry name" value="TNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNT" evidence="1">
        <location>
            <begin position="96"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="201" mass="22548" checksum="8B37DA01DBD814B0" modified="2018-10-10" version="1" fragment="single">YPSTCTDPCLGIIPPNNTSLYCDYCICNNALLGQVNFNATGNWTELFEDYVPLDSQCPKDWLCTWANWTQTGFNSTVLYPPNDGFKGCPKAGSPGVGSYVDRFGSEYGSYLAPAGVPFAERSIPPGNLNKYNGSTQYNYWRFEVIWEFDALEGDILPWFGQPGVGNSGLCREGCVRWWIMGRWCSGRRRLIMVLNRMLGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTA5</accession>
    <name>A0A317WTA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_584878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468545.1">
        <property type="nucleotide sequence ID" value="XM_025615658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTA5"/>
    <dbReference type="GeneID" id="37117801"/>
    <dbReference type="OrthoDB" id="4387832at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="73" mass="8099" checksum="CBC61E9F58E79F0A" modified="2018-10-10" version="1">MATSEKEKLGFTVEVEQAEGPPDQRTSPKAQDLVEEVPDMQDSPSLIETIGYLLSIQDGYGPPDSTWDVDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTU6</accession>
    <name>A0A317WTU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_534496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467969.1">
        <property type="nucleotide sequence ID" value="XM_025611567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTU6"/>
    <dbReference type="GeneID" id="37113710"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021706">
        <property type="entry name" value="DUF2990"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11693">
        <property type="entry name" value="DUF2990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016307333" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="26991" checksum="ECC2D07465677A59" modified="2018-10-10" version="1">MRASLFLLGCLTASSVAAPTLMDDVYDYSTDLATFLGKVSTYIEDAEDLFTNANSCDTSKISLPSYASSLPSPSGLDPIYVAVGRGTQNYTCATSTSDSTPQAIGAVARLYNATCIAANYPDILELLPGIVYKEQLPSNEEDPLPPANLQLLGHHFFRDTTTPVFNLDTTPSRQYGIAISKKQSALDAPSTAIQGTNGAVQWLYLTTIDGTVGDYKAVYRVDTVAGAAPKTCQGMQSVFTVQYSANYYFYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WU83</accession>
    <name>A0A317WU83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_515973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467583.1">
        <property type="nucleotide sequence ID" value="XM_025609944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WU83"/>
    <dbReference type="STRING" id="1450535.A0A317WU83"/>
    <dbReference type="GeneID" id="37112087"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY87800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="282" mass="30479" checksum="C8AA527F35A7622E" modified="2018-10-10" version="1">MSSNKTALITGCTEGGIGAALALAFLERGFHVFATARNPIKAESMKRDNLEILPLDVTSPDSIADCVKSVRSITGGRLDVLVNNAGVMLVAPMLDVSIPEAKEVYDVNVWGTLAVTQGFVPLLVETSGMVVNITSIAATLYVAWQGTYHSSKAAQLSMSEVLRIELEPLGVRVHSVLLGEVESNIYSNGPALEIPASSYYQQVRESIFDGAAGKFIIKTESAEVCARHVVSDVLNGQSGQIWRGGLAGIVKWANRLLPGWLFERYLNAHRGIYSFHPHRKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWQ8</accession>
    <name>A0A317WWQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_462973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468709.1">
        <property type="nucleotide sequence ID" value="XM_025607997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWQ8"/>
    <dbReference type="STRING" id="1450535.A0A317WWQ8"/>
    <dbReference type="GeneID" id="37110140"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016389878" description="Phosphoglycerate mutase family protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18956" checksum="F96B4C62E7BC9914" modified="2018-10-10" version="1">MYSKLSISFGLLATAALALADSTVYLIRHGEKPSDGATGLSSVGSERAQCLKTVFGPDSDYNIGYIIAEQPKSDGKRDRPYETVLPLAEELGLTIDTSCTKADAKCVKKLVKHYSGSGNILICWEHGELTSIVEELGDDNAPTYPSDRFDLIWTDPSPYTDITDITSEDCPGLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WX16</accession>
    <name>A0A317WX16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_545191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468819.1">
        <property type="nucleotide sequence ID" value="XM_025613221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WX16"/>
    <dbReference type="STRING" id="1450535.A0A317WX16"/>
    <dbReference type="GeneID" id="37115364"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY90441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="932" mass="101309" checksum="8EAFE32BE46272FD" modified="2018-10-10" version="1">MAYPQHPAQRAPPVRNYAPRPPARGGGYQGPPQNGHYDYGYDNQHYGYGDAAQDARHGYPGDSAVPRSYGPPRGAPRPPHGGYGPPKEDRGYAYRGRPPPQGYDGRRGYGDRPPPMQDRMRPPARGPHSPDKMAFDNPFPSFPVKDPCGPRGIESGMAAMNLNGGPVPPSQVPDRPHTSHGRRQPRPGSPGRGRGNHPTPPVRSASTGRPRAGSSDRYDRSYTDPSGPPPVPHVNRSATMPVNPAVPPAPSKPLYPGQSTYQDLNSPPQHGQHEHFDTEAWLDSYYNSVHAGDHDMPNFDAMPDPAKGGVIDESLPGLEQPKARAPIESPPSSRGGYTAFNPHGAGDPYPQSPTDTRAAPVPNQFANAGFQFDLPSEGLPGHPGQQQDNAGYAYHANPYEDPYHQGQGSWGATMPQYPESYSGYSVPENYSAPANYPAPANFPVPENYPVPESYPAPESYSAPENPARGNGPPRPYRANQPAPVHEQAQPPSQPESLDAQNNPDALPHHPVPFRPGHDQGSKPAPVRQYDNVSTSASPPAAPQAVPADPAPSGPVTQQELQRLQQLAKSRPSDNKTQLLFAQKLVEASTVLVDASRMDPKTKAKAREKYIMDGNKIVKKLASSGYADAQFFLADCYGQGQMGLNVDPKEAFSLYHSAAKQGHAQSAYRVAVCCEIGQEEGGGTKRDPFKAVQWYKRAASLGDPPAMYKMGMILFKGLLGQSKNPREGISWLKRAADRADVENPHALHELALMYANAGSNDVVIQDEAYASQLFHQAAELGYKFSQYRLGTAYEHGLMGCPVDPRQSIIWYTHAAAQGEHQSELALSGWYLTGAEGILQQSDTEAYLWARKAATAGLAKAEYAMGYFTEVGIGVAANLDDAKRWYWRAAAQQFPKARERLEELKQGGARMQKTRLSRSAVNQQKQNEGDCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYB6</accession>
    <name>A0A317WYB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_21077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468635.1">
        <property type="nucleotide sequence ID" value="XM_025606155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYB6"/>
    <dbReference type="GeneID" id="37108298"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY90257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="165" mass="19413" checksum="FE878CD81709AAC6" modified="2018-10-10" version="1">MKDFWTTQCRERLKTSEMKNGDQERSLADGEDIKKKEELRVATAGYKSTCILNKQAIEPESKRGRRGRCQATINNRRLCPQVPQKRNRIRRDCLRWDCVVVRGKARARCTTRCNDAVCASVYVDVPGDSLGPRRRTRWFCFSFFREAGRKQKIWIETGFNDWSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYG7</accession>
    <name>A0A317WYG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">A-pheromone receptor PreA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_564800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469172.1">
        <property type="nucleotide sequence ID" value="XM_025614449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYG7"/>
    <dbReference type="STRING" id="1450535.A0A317WYG7"/>
    <dbReference type="GeneID" id="37116592"/>
    <dbReference type="OrthoDB" id="2874149at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY91444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="433" mass="48766" checksum="B7E86F2A7113B034" modified="2018-10-10" version="1">MAPTAAPLYPEAILVPVLSFISMLLSIVPLVLHWKNRNFAASSLICWYLVLNLFNIINALIWPTDDDCDVEAKIMIGSYIVIPGTLVCIFRNLAHVLDTSLMVLLFCVIAPVIAMLTHYIYQRGRYFLFAIAGCFNSYDQSWVTLALAWIWPLIICLIAAYYCVLVLHRLAKYRSQFGDILQSANSNLTKPRFMRLFLPAFVMLWAILPVQTYVVSTNIIRTQPWHPYSWSTVHSQEWDKVIKVPTGGHVFYDRWIPVASGYVFCIFFGSGRDASKMYCTILGFLGFGYFFTSLQSSTANGSYATGSTGSRAKLLFHKTWTTTTRTHVNSSVDAARSAHVYRDIEKGATSRAKQSKLASWYRRPWFSQSRHPSSSQERMVALHHMPEPTTTVSTNAWAGVSQSRGSSDIGTTPLAGDHIRVKQVISQESEVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYQ2</accession>
    <name>A0A317WYQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Chitin synthase</fullName>
            <ecNumber evidence="2 9">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_533886</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 9"/>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468775.1">
        <property type="nucleotide sequence ID" value="XM_025611417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYQ2"/>
    <dbReference type="STRING" id="1450535.A0A317WYQ2"/>
    <dbReference type="GeneID" id="37113560"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF39">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="680"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="857"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="11">
        <location>
            <begin position="120"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY90397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="889" mass="100213" checksum="A0F8F4F2C3B5F5C2" modified="2018-10-10" version="1">MGTPNYSAHSPRESESSYFSHASPSQAHPPYHADEPEHDEQEQSLLQRNTSSHYGTPFDDPAVSTDSLRRYTLHDSGPSVFAAPPYQESEGASDIYNARSNGDKASREGSRAGALRRYGTRKINLVQGSVLSVDYPVPSAIQNAIQPQYRDAEEAFSEEFTHMRYTAATCDPDDFTLRNGYNLRPAIYNRHTELLIAITYYNEDKVLTARTLHGVMQNIRDIVNLKKSEFWNKGGPAWQKIVVCLVFDGIEPCDKNTLDVLATIGIYQDGVMKKDVDGRETVAHVFEYTTQLSVTPTQQLIRPQGTETTNLPPVQMIFCLKQKNSKKINSHRWLFNAFGRILNPEVVILLDAGTKPGHKSLLALWEAFYNDKTLGGACGEIHAMLGQGWRKVLNPLVAAQNFEYKISNILDKPLESAFGYVSVLPGAFSAYRYRAIMGRPLEQYFHGDHTLSKRLGKKGIDGMNIFKKNMFLAEDRILCFELVAKAGFKWHLSYVKASKGETDVPEGAAEFISQRRRWLNGSFAAGLYSIMHFGRIYRSGHSIIRMFFLHIQMIYNVCQLIMTWFSLASYWLTSSVIMDLVGTPSKSNKEKGWPFGNEASPIVNNFVKYGYVWVLVLQFMMALGNRPKGVKIPYLLSYLYFSLVQLYVLILSFYLVVGAFNGGMMDFNFDESVGTFLASFFSSSGGGIVLIALVSTYGIYIIASVLYMDPWHILTSSWAYFLGMTTSINILMVYAFCNWHDVSWGTKGSDKAEALPSAQTKKDDDNKQNFIEEIDKPQADIDSQFEATVKRALTPWIEPEEEGGKSLDDAYRNFRTVLVCLWVFSNLLVTLLITATGVDKMCLTNTSTTRTSWYFEVILWITAGLSLFRFIGSLYFLGRSGILCCVSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYX1</accession>
    <name>A0A317WYX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_533955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468845.1">
        <property type="nucleotide sequence ID" value="XM_025611436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYX1"/>
    <dbReference type="GeneID" id="37113579"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY90467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="214" mass="23326" checksum="C0504D02242688E2" modified="2018-10-10" version="1">MRFLCLHGAGTNAEIFEIQSGGISYDLAKKGHTFKYYNGCMEGEVEPQLKGLFPGPFYNHYPRDQAPGENLATAMKHVYQIIERDGPFDAVMGFSQGAALACAMVAHHAKTHQEPLFKLAVFICGALPYDSTGNEVIAVPPPGGEYPVQIPTTNIVGKQDELYSSSMHLYGVCDPAKSKFYDHGSRHLVPFDVENTEAMVAAIEASVQRALTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYY5</accession>
    <name>A0A317WYY5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_555415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469332.1">
        <property type="nucleotide sequence ID" value="XM_025613794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYY5"/>
    <dbReference type="STRING" id="1450535.A0A317WYY5"/>
    <dbReference type="GeneID" id="37115937"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="336"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="971" mass="109357" checksum="2B4049212E641F42" modified="2018-10-10" version="1">MKLTHKDYKVAWICALPLEMAAAKAMLDEVHDSLSQPATDYNAYTLGTIACLPAAATVLSHMLPTFPCLRFALMVGIGGGVPSKDADIRLGDVVVSLPSAMYPGVIQYDYGKTLHDRQFHQTGSLNKPPQFLLTAISQIRSNGMIRNMKLIDAISDILERHGDMQQNFSRPSDDWLFAPSYSHSTSNSDCLACDQSQLVERAPRPTEEPDIHYGLIASGNQVMKDAKTRDSIAQPFGILCFEMEAAGIMDQLPCLVIRGICDYCDSHKHKQWQGYAALVAAAYARTVLLQVPLHDRNTDEVRHSGHWMVPFDQNARFMGREDIIVRLDQWLTQRNRPSKLAIHGLGGVGKTQIALEVAYRMRDTYPNLSIFWIPCTSYESVEQAYMNVAQKFGMSGMKPEEVKEGIRNYLSQDSAGEWLLIFDNADDLDMWMNDSDTGPALKKFIPRSQQGHILFTTRNRALALKLASNLIPILEPDQDTSLSMLGSLIDSDLLVEKDAAIRLLEQLAYLPLAITQAASYIQENEISIPKYLQLLEGNESETIELLSEDFEDEGRYDTIQNPPVSENEGIKAIGLLKAYSFVSEQSEGVFLALHRLNNDMFRMQFSNVFPTDDHFNRTLWREYLPHVLALIDEDDFLEKQHEIGNCLFQDGRHKEAERLALQVLHINQWVLGPEHLETLRSGRLTEAEGLEVQSLKTRRGILGSKHPETLRSMDTLALIYCNQGRLRDAEELGVQVLEARGEILGFKHHETLRTMASLAVTYWNQGRLVEAEELGIQALEGCRDILGFKHPDTLFSMANLSVTYWNQGRLTEAEELGVQVLEARREILGSNHPETLRSMANLAVTYWDQGRLTEAEELRVQVLELRKQILGLYHPETLRTMANVAVLELRKRIIGPEHPETLASMNNLAIILHYLGKTSDALAMMEQCVHLRNKVLGHQHPHTIFSTQTLNDWIAASNALLNLPLSAADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ65</accession>
    <name>A0A317WZ65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Putative ABC multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_616888</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469402.1">
        <property type="nucleotide sequence ID" value="XM_025616810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ65"/>
    <dbReference type="STRING" id="1450535.A0A317WZ65"/>
    <dbReference type="GeneID" id="37118953"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001530">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000913">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="660"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="704"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="783"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="809"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="886"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="923"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="19"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="347"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="15">
        <location>
            <begin position="666"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="14">
        <location>
            <begin position="989"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="619"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY91674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1241" mass="135959" checksum="99212FDD6372771D" modified="2018-10-10" version="1">MSQRILSYGARNGGIVAIVLGLVCAMGSGVALPLMNIVFGKLVGGFNEYFIPGTNVSEQTFKATSLTRPVSLYIVYLFIGKFVLTYISMICFRIVSLHASALLRLEYAQALFAQPVSRLDEMPVGSITNAITGLSNTIQQSVSDRLAVLFQAVALLIAAYAIAFRYSWALTLVVSASILFVIVGYSLTVPFLIKAQQSMDQADGQHASVAAEALGSIRTVLSLGAEAPLASKYIEWTQEAQRRGLRMSAVAGVHIALLFFALYSSFALAFWYGLKLYRDGHISNINTVITVFFSVLIVVGVLGNIASPLMIISKAVSASGAFFGMIDSERPTPGGLRDADVSCQSDITMDNVTFAYPTRPHSKALDGFSARFQGGKTTALVGASGSGKSTVVALLERWYHLQDNDGNIAVGEHSIRDLDVKWWRSHIGLVQQEPFLFNDSIFNNVAYGLIGSPWEDQSDAIKLDLVVQACKEAYADDFIQRLPLGYTTTVGESGITLSGGQRQRLAIARSIVKKPPILILDEATSSIDVRGEKLVQTALDQVATGRTTIMIAHRLSTVRRADHIMVMQHGTVIEEGSHEHLIARGGVYHGLVYAQRLEPLSEVSENKVEGEILSSKEDPQANHYPVADPDDPTSGEDAPSRSISFFKSFRIIFREQSHHWILYVCILVGALGAGSGFALQSWLVAKLVQVFQFSGQKLADAANFWSLMFFILALAMAVCYYALGTASNSISMFVASTYRQDYFLNLLRKPVSYFDLQPNSSGSLVSRLATDPKQLQDLFGPTGVFPLISVFNVTGCVTISFVFGWKLAAVTFFAAMPFLFLAAFMRIRYEIMFENMNAEVYANSSKLVMESMKGFRTVTSLTMEDTIIRKYSTLLREQRQKAMRKAWVGTLVFAFSDSVELCAMALTFWYGGQLLASREYDTVAFFVVYIAIIQGGQSAGQFFSFGPNIAQAKASANRILKERDTPEVITKDPGAETLPATDRRYTADVEFQGVSFQYPARSTPTFEGLDLSIPSGSFVAFVGASGCGKSTIISLLERFYEPTGGFILFGGRDIRSIELPSYRRALSLVAQEPQLFGGTIRDNLLLGLETTDEGVSDAMEQACKDAEIHDFITSLPMGYSTELGVNAQSALSGGQKQRLCIARALLRKPRLLLLDEATSSLDSHSEKVVQDAMERLAAKRDMTIIAVAHRLATIQKADVIFVFGEGSDGRGSRILEKGNHHDLLRRKGMYWQMCQAQALDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZT6</accession>
    <name>A0A317WZT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_533344</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469634.1">
        <property type="nucleotide sequence ID" value="XM_025611310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZT6"/>
    <dbReference type="STRING" id="1450535.A0A317WZT6"/>
    <dbReference type="GeneID" id="37113453"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000053">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="14"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="288"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY91906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="460" mass="51579" checksum="7374C60DCA75552C" modified="2018-10-10" version="1">MPVTDFKHADPYSYQTGFDSYHETEAIKGALPVGQNSPQKAPYGLYTEKLSGTAFTAPRHENRQTWVYRILPAAAHENFVAEDGDSYHTHMTTETQKLHHIPNQLRWDPFDLDETVDWVHGLHLVAGSGDPTLKHGLGILLYAAGKDMGKEAFYSADGDFLIVPQHGVLDIQTELGRLLVRPNEICVIPRGVRYRVTLPAGPVRGYICELYQGHYQLPELGPIGSNCLANIRDFQTPVASFDDEEEPSEYRLYSKFNNTLFSARQRHTPFDIVAWHGNYYPYKYDLGRFNTIGSISYDHPDPSIFTVLTGPSDHTGTAIADFVIFPPRWLVAEKTFRPPWYHRNTMSEFMGLICGGYDAKTGGGFQPAGASLHNVMSAHGPDKNAFEGASNAELKPQKVGEGSMAFMFESCLMVGVSEWGLKTCKKVQGEYNAHSWQPLQRHFKNPNKSVDVDTMCQDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZZ6</accession>
    <name>A0A317WZZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyanate hydratase</fullName>
            <shortName evidence="5">Cyanase</shortName>
            <ecNumber evidence="5">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cyn1</name>
        <name evidence="7" type="ORF">BO94DRAFT_564981</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZZ6"/>
    <dbReference type="STRING" id="1450535.A0A317WZZ6"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY90298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17994" checksum="9179F71A4D624A84" modified="2018-10-10" version="1">MSLATLDVTQHPYLPSASETLFHAKATKKLSFEQIAQHIGRNEVAAAAIFYGQAKASPEDIEKLASLLDIPHDLLEEKLSGFPDRGRTVEMPPKEPLIYRLYEIVQNYGYAYKAVLNEKFGDGIMSAISFSTKVEKETDQDGNNWAVITLRGKWLPFSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3J9</accession>
    <name>A0A317X3J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FTP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_583376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469897.1">
        <property type="nucleotide sequence ID" value="XM_025615556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3J9"/>
    <dbReference type="GeneID" id="37117699"/>
    <dbReference type="OrthoDB" id="5334969at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="749" mass="83468" checksum="F735ABA207E76F14" modified="2018-10-10" version="1">MLFDKIPEVEVVRTQNGALRSLDHAQQPWPPTSRDQIVEGPSNPRSAAEQYLQQVAGNYKVTPGLNSLTDSGFDLQFEQEKTRFKSTAVIYRKTFNQWPLWDAQLSVTVREGDNRVTNSSSTLHTDASGPELPGDDAKFLNRAVKEEDISLSLGVPVCKDCIGFTEEHEKNEQRILVYRYSAKGRQEQAGDSPPILAFPEVPKKIQDGHYYVVREALFSFPISGYGSLNWRAFFEVETGSMIYLQALTAGLTGWVFSRDPVTKLGHRAPMPAGSVADLNMLRDRVLLPETVTSSPQVLKGRFAVVKDTSLSIRLPPTTTTGDFNGSVDSDIFAAANAYYHITKLFRLLGELGFSVKDFFNETQFPVPVDHRGFDDQVNAQAPRNATGTGSGGFIFGRADSNSQVGMAADFRIAGHEFGHGLLWDAIHWPGFGFAHSPGDSLAAIYSDPGSDAQDRFDTFPWNTLVRRRHDRRVTDGWAWDGPQYRQDNLAYYRREQVLSTALFRIYRAIGGDAIGDIHRQNWASRYTLYLILGGIATITTRMPMPYQYVSAMIAADDGVGLYHPPNIPDPGVMTEGPPPAVDVYIDDGRDGEYDYTLLSDNTPGIWNWQRADNGLVNQISIPGATNYCYVAVRNHGTRPAHNVKVTLYQSNRPAPTLWKAHFDELSTAQLDNPLTGNKQQQHIFGPFPWVPTKNPFFDRHYILAAVRADGDLPNTDPNTGLDCATGPTEIDNLVPFDNNWQFVTLTTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4U0</accession>
    <name>A0A317X4U0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_459374</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470380.1">
        <property type="nucleotide sequence ID" value="XM_025607837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4U0"/>
    <dbReference type="STRING" id="1450535.A0A317X4U0"/>
    <dbReference type="GeneID" id="37109980"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF4">
        <property type="entry name" value="DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="12">
        <location>
            <begin position="7"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY93619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="429" mass="45045" checksum="50AA4226738EFC00" modified="2018-10-10" version="1" fragment="single">PTYKTPWNPTPLVESTTLSRAAGCRIFLKLENIQPSGSFKSRAMGNQILSHLRKPENFHKPVHFYASSGGNAGLAAVCAARTLGYPCTVVVPVSTKPLMVQKLRNAGAADVIQYGETFSEAGQYMKDVVMSGGSGDGGEESEDVVKIALHPFDNEPIWAGNSTIVDELVEQIPPAVGEEEEETHAGRALPVDAIVCSVGGGGLLNGLVMGIERYRDAADADAKPVHIVAVETKGTDSLATALEKKELVSLPKITSQATSLGAIRVSERTFRYAVEPPPGVKVHSAVFSDAEAARGVLRLVDDERLLVELACGVCVEAAVGGSGASRSSGLVSAGQKRKRGVEVEYVGKDEGYGDDRLSAGENEDDSPAPSVSSSSSSSPGGLQSKLKQLVPGLTADSRVVIIVCGGSNVTIDMAAEWRKMLAEGWATLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X533</accession>
    <name>A0A317X533_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Aspartic protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_350156</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470475.1">
        <property type="nucleotide sequence ID" value="XM_025607096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X533"/>
    <dbReference type="STRING" id="1450535.A0A317X533"/>
    <dbReference type="GeneID" id="37109239"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000085">
        <property type="entry name" value="Aspartic-type endopeptidase (CtsD), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000060">
        <property type="entry name" value="Aspartic-type endopeptidase ctsD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF75">
        <property type="entry name" value="ENDOPEPTIDASE (CTSD), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016447594" evidence="16">
        <location>
            <begin position="20"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="17">
        <location>
            <begin position="106"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="410"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="412"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY93714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="478" mass="50387" checksum="025352B9B1081D21" modified="2018-10-10" version="1">MHLSQRLVTAACLCASATAFIPYTIKVDASTSDSARDTLSRRFLPLPKPGDALTDDSVSSSNDESLTLNIKRIPVRRGNDFNIVVADTPSWPNTAALDQDGNDLSYFSVVNIGSENQALYMLLDTGGSDTWVFSSNCTSTACTMHNAFGANSSSTLEMTSDEWSVGYGTGSVSGLLGTDNLTIANTTVRMTFGLASNASDDFESYPMDGILGLGRTNESSYDNPTFMDAVSTSNLFKSNIVGFALSRSPAKDGTVSFGTADKDKYAGDITYTDTVGSGSYWRIPVDDAYVDGTSCDFSNKSAIIDTGTSYAMLPSGDAQTLHSLIPGSNTSGNYFIIPCNTTAKLQVAFSGVNYTISPKDYVGSTSGSGCVSKIVSYDLFGDDIWLLGDVFLKNVYAVFDFDEERVGFAERSSNTSSSSNSTSSSTSSASGSTATGSSTTTGSASSSTSSDTKSGGMAIAPPQYYFSALVIALYLLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5M8</accession>
    <name>A0A317X5M8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_583011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470396.1">
        <property type="nucleotide sequence ID" value="XM_025615523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5M8"/>
    <dbReference type="GeneID" id="37117666"/>
    <dbReference type="OrthoDB" id="5100247at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17319" checksum="D1DE80E86BE1D5E3" modified="2018-10-10" version="1">MSTISADDNPPKSPEPLFLDYPVAHVLNKSSRRAWVEPWASRYCAAVSDKRYGDAIWARYNMDGRTVDGEYKSLSMIGDGSVKEVSVPVYEMIMDDARGYAKSSPDCYREALLLYNTTSRSDSRRDIIEGLNQIDTGSSLVTWAFSSLRGVFGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X625</accession>
    <name>A0A317X625_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multidrug resistance-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_487615</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469853.1">
        <property type="nucleotide sequence ID" value="XM_025609045.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X625"/>
    <dbReference type="GeneID" id="37111188"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF404">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="486"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="925"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1028"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1112"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="275"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="608"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="890"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1208"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="831"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="848"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY93092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1439" mass="159112" checksum="7C998ED864127A48" modified="2018-10-10" version="1">MANPVCVATSDNQFGPRVDPNCRSFDFTLLFEDAFFSIIPAALFILLLPARLRVLRKAPVKVTTYRLAVYKTICLVTLFALQIVYTVYHLCTPALHTRLATTSDILTIIATAAATFLSLIEDQCSIEPSDILVIYFSALTLLDIPRLRTVWLIPGVDICRGLWTTIYVLTVVALFLESMRKLRILRTLYQNVTMEQVIGFWGRSFFVWVTPLFRVGFSDILSVEDLPEADEDLRGDAARRKLNGAWEKSKGKRRLLKAVFRAYLWSALSGIVPRIVLSAFTFCQPFLITSAVDYFEKDSTAEIKQYGQALVGAFLLVYLGIAISTAVYWRQVYRLMTTVRAGLISMIYQQTTNLSGNDVKDTAALTLMGTDVERIGNSLRLLHETWASIVEVGVALYLLERQIFLVCLVPAAITVACILGTHPISSRSGSAQKAWVEKVQTRVAVTSAMLGDMKAVKMLGLADVLFDLVTKLRKAELEASSRFRKLFIFMVVLSNIPLDFAPYATFAVYAIISVVRNDRSLLASQAFTSLSLISLLTSPLVTFVRAVPQLAQCGGSFERIEAYLEREPAAKGHQTESLISLTLPDLENEDVELTKRATGQSADSLVSFTGVDIAWTHTTELVFRNLHLDIKPGITMIIGPVGSGKSVLIESILGETIIKNGTTNAPLSNIAYCPQKPWIVNNTFRHNITGGTEFDSKWYGFCVSASGLEDDLASIPGGDLHMAGSDGVSLSGGQKQRVALARALYSRHPIILLDDVFSGLDSKSISHIFSTLFAKDGFLREAGRSVILATHTQSLLPYADEIIALDKGTVAARGSYQDVLARTPEIAANSLTKPKNQEQVSEDDVQSKPKTAQVTAVENSPTAKPDLSRRDGTWDVYRYYAKSAGLRVTFGFIACSLVSTFLKNFSTLWIEWWSESNARDPNGQVGFYLGLYTVFAVLNASGLAVACYLLFMKAINGTALGLHTDLLASTLNAPFSFFQTTDTGTLTNRFSQDMDLIDMTLPICLINSFGNGSSTIIKLIILCAVGKYMAATFPILIATFILIQSYYLRTSRQVRLLDIEAKSPLYTHFTETIRGISTIRALSWQSVFQTDFEHKLNQSQRPYYMLFCIQQWLNLVLNLVVTAMAVILLAITTSMKDKFSAGAIGVALNMVLSFNQEIVRTVQSWTQLETSIGAVARVQKFQEETPSERSGLSMPIPPVYEWPVEGKIVYEDLTAGYTNTPTPTLNNISLTIPPGETLAICGPSGSGKTSLIMSLLGMIDIHEGRVTIDGRDLTSFDPRDIRSRVTVIPQDPFFMPGTVRFNLDPHGNASDEVIESALRKVGLVAGLDSELKADDWSGGERQLLALARALVNPSRVLVLDEAMSSVDGETERLMQEVIEREFAGRTTVIAVMHRLRYVERYDRVVLLKRGEVVECDTPSRLLGRESEFRRLCSSLDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6E6</accession>
    <name>A0A317X6E6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_543405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470914.1">
        <property type="nucleotide sequence ID" value="XM_025613136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6E6"/>
    <dbReference type="STRING" id="1450535.A0A317X6E6"/>
    <dbReference type="GeneID" id="37115279"/>
    <dbReference type="OrthoDB" id="8596411at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="146"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="515" mass="59030" checksum="6366FAA2139719FA" modified="2018-10-10" version="1">MTTNPGSLSQLGWSSEFLDLVRDLTCEQSMTTENHRASYPWIYDWPPSLATVIHDLLDPQSELAANQPRLHEILVRRYSASMKARQEDREVSKCSHLFTNGEHRTDSYEYQYHIHAHGSTVADHDGNLAAAITYYANLCPDIKDNFVIRGILGIGSYGAVFLAHKSEDKSNKLYAIKVEPLTTINASVNPVPYYGNPPSLAPLYYPEDLRLRYIPIEAFILLLVNGFDRFLKLDSVYSHQNFSAMVMEAQIDQEAQSRPYDPSGSIHDWLKEAKNQAVCNGAKLINRKQTSLNEIQACKVASHLFEAIAYLHDMGICNTDLSHGNYLVDEQLNTRMIDLGLLHFGVNDQDFSMHKTAYIPSYERSMTPELAIELTKSHWLRKFENQVEASVDIPHDVRQLTCWQLATIIYELLHGFAPWEEKEWDELIGGITEYMAHGIDYRRLGKVRERRGRIINEDLPISENLSQDCVDALRMMFVKNPEERPSIEMMATFPWFGQWTSHSPEEFQRPPFPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7C5</accession>
    <name>A0A317X7C5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_484628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471277.1">
        <property type="nucleotide sequence ID" value="XM_025608965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7C5"/>
    <dbReference type="GeneID" id="37111108"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF64">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="406" mass="44437" checksum="53B86BFA17CA47D6" modified="2018-10-10" version="1">MGWVHNLTHPDPHSHIARVIAVCLVFSISAVIAVGLRLYIRLHTKRALWLDDYAVACSAVLGLGYAGISVAQTRYGLGLDAAYFPDANVVMFSKIQYAGGPTYILAILCFKVSLLTSYLRVGGFVAAYRWVIIVVVVAVVCNQVVFTLLLTLACNPVAKQWDTNLPGKCIDTVASYYALAGTSLGFDMLIIALPLPVLWSLQLHHSQKVALIGLFALGFFITIIQIIRIFTIKNLKTYTDSQPIVLWSSVEIGLGVIIACIPTYGPYFHAFASTLTSSYTSRRRKRHPSQSQTLDPTRSYGMSGVRRTQRNQSRMLPSETDDQAEFLELGEVNAGRNRPWDNAAAVTTTIGHGDGDEEGSSLGSGRRSGSGRGSGEGGRNRMEEERKDGDGPLQIQRVVELEVRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7M0</accession>
    <name>A0A317X7M0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_563207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471377.1">
        <property type="nucleotide sequence ID" value="XM_025614345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7M0"/>
    <dbReference type="STRING" id="1450535.A0A317X7M0"/>
    <dbReference type="GeneID" id="37116488"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057503">
        <property type="entry name" value="PH_RdRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF17">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25358">
        <property type="entry name" value="PH_fung_RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RdRP-like PH" evidence="3">
        <location>
            <begin position="128"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="2">
        <location>
            <begin position="424"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1217" mass="138601" checksum="FEB3BFE43E5C9E72" modified="2018-10-10" version="1">MEVFMHNVPRQLTDEGLKRQLEPLLKQLGIVDFFCDKPKKKNFGFLTFRHREDGVRFLLFHGQEEIPGTLNTRGKPRFKSKLQIMGTDVFCAPSKNPPNKFALQSLQHAADQRANDTLHKYEKDDRVSFRVLGFSCGYYKFVGDELGYIPEVQWSDTGIMKFKRRFIMVKLKTNYNIRIPLNTVIELIWSRDGSLTLTLSTVPYFFIEEGSMETIVMQMLELDVRGLNRYLPTSSRSRMCSLGEAHTGAVGQCLVYQFRVPPIHLMTAIQDLKEWEMSIVQYDIIVPHLTIMEPFETQMKTLKSELAIYTRQSSLPFGILFQLQALAYNAYLLPHTVSSLAKELIRAYKEDISAGRRPISVLAMKKLLDMIDWPSPHSNPTDFEPTSLLAMLKQNNKEIIQDLAVSGESLGPTDNLTPIHKVMVTPTRVTLHGPELEPWNRILRRFPNHHDYFIRVQFCDEDGQDLYFNSQVSYDDVFSRFKAVLTRGIQIAGRTYSFLGWSHSSLRSHAVWFSSPFVDEDGRFQTHFSIIKALGDFSKIQSPARCAARIGQAFTDTPFAVSLSDYHIEVLEMADVTSKDKSRVFSDGVGTLSWDVAEFIWSNIPVKKGYPTCFQIRLGGAKGMLAVDSRLSGPRINIRPSMIKFNGEMKDLEVCDMASKPVRLVLNRQMIKILEDMGTADDWFFGLQNAAVAHLRQVTASAHNTEVFIKKQAVGDSIGLFRIYRQCHLLQLDYKKEPFLRSLVEAVVLKELRLLKHKARIPVSEGITLFGIMDETGFLEADQVYVTYNPVKGRHAPPPKAGKLLVTRSPALHDGDIQYAYNVIPPAEHPLSELTNCIVFSSKGDRDIPSQLSGGDLDGDIFNIIWDAGAHPIRTFAPADYPRVSPVDIGRPVQRDDMAQFFVDFMKTDHLGMIAMRHMVLADQEDGGTSHPNCRKLAQLHSTAVDFSKTGIPVQISEIPRGSNFRPDFMAPGPLAHIHSKSEIELDQYVFQAAYDEDDPEPSRKYYRSERILGKLYRAIDERKIWNEDVHSNVSADEDEFWNEFLWSTYERCNSIGPISWERWLDEARRVRLVWLRYEEAVFSARNNYSDHPINPISELEVFIGSVLNKGGVQTRRQRDQSTKLADEFDRISTWIVNQMRGSSTAGPTTKPSDPLDPLEFCFACIHAGGETDQGSTRRRRDEYGELKSFRIVASCALLFELDQFEKGKKQPLGSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7Q0</accession>
    <name>A0A317X7Q0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_572788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471076.1">
        <property type="nucleotide sequence ID" value="XM_025614936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7Q0"/>
    <dbReference type="GeneID" id="37117079"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="134" mass="14158" checksum="FF0218C5063112E5" modified="2018-10-10" version="1">MTHSASSPPSSPSLIPNYSVKYSLYGVSISLPNQPNPTQPLTGSASGSGDGDGAAIPNQPSQPSQSQSNPSPQIVPICLCIMTTCSTCTWYMVHGTWDTDLPYPVGCTNDKSARVNNPYHTPIPTQPNPIITNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8Y9</accession>
    <name>A0A317X8Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_512537</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470129.1">
        <property type="nucleotide sequence ID" value="XM_025609815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8Y9"/>
    <dbReference type="STRING" id="1450535.A0A317X8Y9"/>
    <dbReference type="GeneID" id="37111958"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000006">
        <property type="entry name" value="Gamma-glutamyl phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00077451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY93368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="455" mass="48624" checksum="56535339935BEAF5" modified="2018-10-10" version="1">MSLTQSSALDIASTASLAARRLAILSNIERNEALTALYQGLLTNKDAILTANARDVASASRAAEKGDLNSSVLKRLDLSRPGKYDDMLQGILGVRELKDPIGTVTLRTLLDDGLTLERVTCPIGVLLIIFEARPEVIANIAALSIKSGNAAILKGGKESTESFVAISTVISEAISNTRVPKSSIQLVQTRDAISSLLAQDSLIDLVIPRGSNDLVRYVKDNTKIPVLGHADGICSAYIHHDADLETSVRVIVDSKTDYPAACNSLETLLVHETVLRTILPAVGNALVAKGVMLRCDESSKSALKDTLGAAQMDSIVDAVDSDYNTEFLDLILAVKTIPASASGLDVDAAIAHINTHSSKHTDIILTKTRSTAEYFMNSIDSAGVFWNASTRFADGMRYGFGTEVGISTNKIHSRGPVGLDGLTIYKFLIRGDGHRAGDYVEGEGGKQWKHKALPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9B9</accession>
    <name>A0A317X9B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endo-1,3(4)-beta-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_572702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470968.1">
        <property type="nucleotide sequence ID" value="XM_025614934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9B9"/>
    <dbReference type="STRING" id="1450535.A0A317X9B9"/>
    <dbReference type="GeneID" id="37117077"/>
    <dbReference type="OrthoDB" id="4388755at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF4">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016338849" evidence="2">
        <location>
            <begin position="22"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="410" mass="45841" checksum="D20CBACC3BE89988" modified="2018-10-10" version="1">MKLVFHFLLPSLSLLATTTTALSIPQPPTTQPTNNKSTNNPHSLCDCYLTTGPDPGYFTHYKFWDFRNVTLPQGIETTQTNPANPHDSSNLQTYPLSKSPFNRDWHAQTWKRGATPISPVPMVNTDRNVFLLKDPSSSSSNPRSSSLVLRTTRFADHASTAEVEGLFGYIYHCSLRLRLRMMSRDAIVRQAAVPNTDIATTAAEARNSVPRGSCAGIFTYRSAVCESDIEILTSEDPHTVHYANQPDYDPISDTLIPGASSIVNLSTPWTSWATHRLDWLPNLSAWYADGLLQSNSTYSIPNRPSIVAMNLWSNGGNWSGDMRIGDSVYMGIEWIELVYNVTKADQDLPIKDHPGHRDHYRRPLDHTSMGDDNLARHSAAEVPRAHIEPRTGKKSGGCQRPCWIDQWQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA76</accession>
    <name>A0A317XA76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome biogenesis protein Kri1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_619895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472225.1">
        <property type="nucleotide sequence ID" value="XM_025616897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA76"/>
    <dbReference type="STRING" id="1450535.A0A317XA76"/>
    <dbReference type="GeneID" id="37119040"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="483"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="545"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="616" mass="70568" checksum="1B269B39AB7E4706" modified="2018-10-10" version="1">MEPPSKRSRKLLDDDSSSDSGDESGGVPITNEDITFKINEDYARRFEYNKKREEKQQLESKFGKSSVLGKRRDRDGEDESGNSEDDSSDEEEDEDGELATTALDAEIMATLKAIRSKDPRVYDTNTTFYTPLDEEATAESSGKKEKPMTLRDYHRENLLSGANLADEETTEAPRTYAQEQEELKNAVVREMNAATAGKDASDDEDDDDDDFLVAKSKPEPIPAPKTDVNVDVENADKDPETFLSNFLSARAWIPAGRSELQPFESDDEEEDQRADAFEEAYNFRFEDPSKINATLITHSRDTTNKQSVRREDKSSRKKRRDAEQQQKDEEKKQRDTEKNRLRKLKMEELQERVSQIKEVAGIRASEMTDEDWAGFLDAAWDDKDWEKEMQRRFGEDYYAEDDKAGSGDESGHKKKRPKKPTWDDDIDIKDLVPDFDDEEKPVLGGSDVEMEDGDEEASGSNKKSKAQERRDQKREARKDRLRIEEALDRNLDLDISLLPGATRKNATGFRYRETSPQSFGLTARDILMADDTHLNQFAGLKKLASFRDPEKKNRDQKRLGKKARLRQWRKDTFGDEEGPKIPEQGPSAPTPKEDADNVDIRDGEPKKKRRKRSKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAG1</accession>
    <name>A0A317XAG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HIT finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_580761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472334.1">
        <property type="nucleotide sequence ID" value="XM_025615349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAG1"/>
    <dbReference type="STRING" id="1450535.A0A317XAG1"/>
    <dbReference type="GeneID" id="37117492"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000005">
        <property type="entry name" value="Putative HIT finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="5"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="189" mass="20972" checksum="7FC085FAE6352D20" modified="2018-10-10" version="1">MPGTCEVCVSEPSKYRCPTCGLMSCSLACTQSHKIYCAPKAPSPKPSDQTGDAQPPSGEANGNATSEVASKAQNGLDLRSLRTSTELKDLLDRFPSLREELYKIYKETTEEAWPETQNHGGRARPWGRGRPPQRNRGPWTREKGFNRGVGRVRKLRERCEEGLETGKKAEGFVRFMALITGNEIPQEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAH9</accession>
    <name>A0A317XAH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_455177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472354.1">
        <property type="nucleotide sequence ID" value="XM_025607640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAH9"/>
    <dbReference type="STRING" id="1450535.A0A317XAH9"/>
    <dbReference type="GeneID" id="37109783"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="56"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="273" mass="30446" checksum="EEC40014F60CE961" modified="2018-10-10" version="1">MLSTRRSQSHHPDSFSSRYRAGKSKARSRDQSVASRRLHRRHSPDTPPDGSSSNQGVITLTIGPTKRLFAAHKDILCVSPYFAALCNRPSDSSSASSSSSPNPIDLPDEQPEIFSCVLEYLYRGDYYPRLRHDKTNNTWDLETSAANNTTTSTNRDTDPGATIFVPAAGAEILRDTAVYCAAQKYSLEILKRLALKKQGLHSNIPCHTILTSARYAYAHTPDNESKLRAHYLALIIRSRGTFKRSGTMQMEMEQGGKLFFDLFVAMCNHMVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB86</accession>
    <name>A0A317XB86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase/ reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_458326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470989.1">
        <property type="nucleotide sequence ID" value="XM_025607786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB86"/>
    <dbReference type="STRING" id="1450535.A0A317XB86"/>
    <dbReference type="GeneID" id="37109929"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF124">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="247" mass="26748" checksum="1A89E74672C49AD4" modified="2018-10-10" version="1" fragment="single">GIGRTTAFTLAQNGIDALSLFDLDPALLQLTKDQLQASRPHVLVETTAGDVSKEACVEEAVRRTVDRFGRIDISVHCAGIIGSMVPTHELTVQDWQKVIDINQTGVLLCEKVVIRHMLTQESRGFRVGRGTIVNVASMFGVVVPTGGSGLMAYTAAKHAVVAISKLDAKAYIQHEIRINAVCPGYTDTRMTRTWYEGGHLDQELEHRAVIGRQAQPEEIGDVILFLASPMSSYMVGSALVVDGGYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBQ3</accession>
    <name>A0A317XBQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Polyadenylate-binding protein</fullName>
            <shortName evidence="14">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_454458</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472302.1">
        <property type="nucleotide sequence ID" value="XM_025607610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBQ3"/>
    <dbReference type="STRING" id="1450535.A0A317XBQ3"/>
    <dbReference type="GeneID" id="37109753"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000355">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000384">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 13 14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="51"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="139"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="232"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="335"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="17">
        <location>
            <begin position="654"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="369"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="381"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY95541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="727" mass="78395" checksum="2EE13B8EAB93CD91" modified="2018-10-10" version="1">MSADAATTPAVENVNGAAEASPAAAAPSGTPEVTAVENSAPAPSANQPHSASLYVGELDPSVTEAMLYELFSSIGQVASIRVCRDAVTRRSLGYAYVNYNNTADGERALEDLNYTLIKGKPCRIMWSQRDPALRKTGQGNVFIKNLDSAIDNKALHDTFAAFGNILSCKVAQDEFGNSKGYGFVHYETAEAANNAIKHVNGMLLNDKKVFVGHHISKKDRQSKFEEMKANFTNVYIKNLDPEIEDDEFRKMFEVFGEITSATLSRDQEGKSRGFGFVNFSTHESAQAAVDEMNDKEIRTQKLYVGRAQKKHEREEELRKQYEAARLEKASKYQGVNLYVKNLTDDIDDEKLRELFGPYGTITSAKVMRDTNVERASSPDSAGKEKEANKENDKETVEAEKAEEKASESSEEKDKEGKKSEKKPFGKSKGFGFVCFSSPDEASKAVTEMNQRMVNSKPLYVALAQRKDVRRSQLEASIQARNTIRQQQAAAAAGMPQPYMQPAVFYGPGQQGFIPAGGQRGMAFPPQPGMVMGIPGGRPGQYPGPFPGQQGGRGMAPNQQIPPNFAQGIPMGMQGPGGIPNGMGYPGAMAQVQFGRGAGGRGQVPGMPMGQGMRGGPGYGQGRGGVPVQQGNVRPGQGGRGQNAAQPAGREEAAAGGLNAQTLAAVPPAQQKQMLGEALYPKIQAQQPELAGKITGMLLEMENTELLSLRKMPFAPRSTRPLASTMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBZ7</accession>
    <name>A0A317XBZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_581477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471898.1">
        <property type="nucleotide sequence ID" value="XM_025615412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBZ7"/>
    <dbReference type="GeneID" id="37117555"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Leucine-rich repeat" evidence="1">
        <location>
            <begin position="155"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="422" mass="48293" checksum="46AFF7E1C2D92B2C" modified="2018-10-10" version="1">MHLPILRLVMVSHRGSMPWGFFGVVPGSEAGAFCDIVETEKRRTHLEVEQSQKCPYDEKFYQSDSEEDIGDFASIHDMVTEICDTDQDKDWWSLHLQNSCGWAWLAVLLTRLTHLQSLSISHIKEGFLLDVLVKAAKRQHPFDKSTPFPFFRDVELTCPLENEMIWSDHAMPFFYLPAVRKVNALKVYEGSPGSYTKPDFADHRRSECPVTEINLIHTIACDDINDWIAACSKLEHFHLEFGMINSIKHTEGYNPLTAQAFRRSLLSAKYTPKSLRLEFRVSYKTYSKHHAEQSKMNLPFGSFKEFHVLENLFMRHANLIRSPNTGPMKEYSPDHELLIQILPRSLKSLEIVDIMDNTFPALVWDLVKLVTRREDMPQLRSIVLHVNDGDSAINKGLIGVIECACQSTEVCLTIKGSAPINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC07</accession>
    <name>A0A317XC07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynactin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_531055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471908.1">
        <property type="nucleotide sequence ID" value="XM_025610814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC07"/>
    <dbReference type="STRING" id="1450535.A0A317XC07"/>
    <dbReference type="GeneID" id="37112957"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="479" mass="51667" checksum="D1FCED1E2D8C5B26" modified="2018-10-10" version="1">MSFNRKYAGLPDLDLAPDIYETPDLTDEASTLPTTTIRTASNADDDAGSNSDIDREGINADEARAHFLGATVDARDVNFSDSIAMKRKAYKNKNRRRRRQENGLEDPEDFSDGEDESLERKLARLRREVEELKDEMAARQSETEITEAPADGKEAVGDGVLELSRALDNLYTSRSDTGSHSAAAMLSQRITTKPTPEASATIPSNQDAESTQPDTTASPSTGVLAHAAAFDGRLALIEAAMGLSNSSNPFVSDGISEPALQPVLPALDHLTSRLSTLMNILVGPNPVSAVPTMGSAPPSTTVTTPQLETLSSRVRKLTADTEALASARKRAVDAAKAAQNARIASAAIEPSDMSVSSSSATEVDPAATQRDEQATKIQALYATIPTIQSLHPILPSVLERLRSLRVIHAGAAQASESLDTLEKRQADMAREIEQWREGLRVVEEKMNQGETAMKNNIELVEPWVRDLEDRLDRLEGTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC23</accession>
    <name>A0A317XC23_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stress response RCI peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_532047</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470851.1">
        <property type="nucleotide sequence ID" value="XM_025611038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC23"/>
    <dbReference type="STRING" id="1450535.A0A317XC23"/>
    <dbReference type="GeneID" id="37113181"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="155" mass="17059" checksum="C53E0BBBD1223D69" modified="2018-10-10" version="1">MCGSDIFLAILAVFFPPVSVWIKVGICTADSIINLALCCLGYVPGLLHAWYIILKYPEPDYDDPSYEPLPGDAENGRVTYYYVSNQPIQHPSQRGYGTVPSQQPQAPKTQSQNRQPAPNQPHEQAQASSSSQDQADSRPPPTYAEAVKGDHKVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCC5</accession>
    <name>A0A317XCC5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_531260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472103.1">
        <property type="nucleotide sequence ID" value="XM_025610858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCC5"/>
    <dbReference type="STRING" id="1450535.A0A317XCC5"/>
    <dbReference type="GeneID" id="37113001"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="517" mass="57687" checksum="65C76E00117DF3DE" modified="2018-10-10" version="1">MTTLIPREPYSQEELERLYPQDLKLQLVQVFLRHGERTPVSSRFQNAGLAPYWPYCNVARQMIQMASSNKDITSWNGFQWRRKTEAFGDKDQSVVAVGAGGDIEGICQHGELTDKGRETTFALGQRLRHLYVDQLGFMPKIKADTEDMYLRATPIPRALESLQQAFWGMYPASARTQDFPPPVIVARSVSEETLFPNEGNCRRFRQLARLFAKRAGERWDNTEQMDYINKRLSKWMPESSPRIAVNGHPQLCGIMDTINATDAHGPATKLPSEFYDRKVREYIDKISVDEWFAGYTESNEYRKLGIGALLGDVVDRMVSTAVDGGWRSETSASGSSPNNGKAIKFAMSGCHDTTLAAILSSTGAFDGIWPPFTSSVAIELFSKAEQAQAQAPAPTSEATPKNSGLFSFLTGSSPTTNNTPQPSETARVPLSSFPESSKQSLRTHYVRIRYNDRPVRIPGCAAKAENHLPGDESFCTLEAFKEIVDKFTPKNWRQECLQNIGEGLYGKDDSEKSTAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCN2</accession>
    <name>A0A317XCN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_453622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473137.1">
        <property type="nucleotide sequence ID" value="XM_025607575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCN2"/>
    <dbReference type="STRING" id="1450535.A0A317XCN2"/>
    <dbReference type="GeneID" id="37109718"/>
    <dbReference type="OrthoDB" id="4153866at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF5">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016334752" description="Altered inheritance of mitochondria protein 6" evidence="2">
        <location>
            <begin position="24"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34205" checksum="B9D4F7D9EBD0BFA0" modified="2018-10-10" version="1">MVLAPSLVAASAFLLGVPRLAAAGATELQSVLKNTHGGNEYGYPTDFTRGIMPIPVHSHNDYWRDIPFYTGISKGCISTEADVWLYNDTLYVGHDESSLTESRTLESLYINPMLDVLKRQNPTSRFVTSPTNNGVFDTSTAQTLYFFIDVKTSGPETFAAVIKALEPLRERGYLTSLKNNNTLTTGPITVIGTGNTPLAMVGPVADRDYFFDAPLGALSESRYQDIDQYISPIASTNFGAVVGMIEGGEVSGEQRDVLRKVINIAAQRGIGARFWGTPYWPIRVRDSVWRTLVDEGVALLNADDLDAVTKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEK1</accession>
    <name>A0A317XEK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7 11">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_563005</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 10 11">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7 11"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472139.1">
        <property type="nucleotide sequence ID" value="XM_025614325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEK1"/>
    <dbReference type="STRING" id="1450535.A0A317XEK1"/>
    <dbReference type="GeneID" id="37116468"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000009">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017390">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038120">
        <property type="entry name" value="Ubiquitinyl_hydrolase_UCH37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 10" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="12">
        <location>
            <begin position="6"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 10">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 10">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="9 10">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038120-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY95378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="320" mass="35477" checksum="F724B8C317D9150A" modified="2018-10-10" version="1">MADGGGWSTIESDEGVFTSLIENLGVKDVQFEELISLDADIIRSLSPVYGVIFLFKWLRETTTTTQPTSTSTPPSGTYDLNPPQTLFFANQTIQNACGTQAILSVILNNDSTSPTPPNPPIPLGPALTTFKDFTTGFPPDLLGEALSNSEPIRTAHNAFARSSPFADETIRQNQDDEGGDVYHFIAYTPVAGKLYELDGLQPHPISHGECGREEFPEKVIEVLRERIARYPEGETRFNLMAVVRDLRVGAREIGDGEALEREERKRRAWAWENTLRRSNFVGFIGEVLKGVVGGFEEWVERAKGETRKNLLRRGGNTDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEN5</accession>
    <name>A0A317XEN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_507997</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the THOC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471831.1">
        <property type="nucleotide sequence ID" value="XM_025609645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEN5"/>
    <dbReference type="STRING" id="1450535.A0A317XEN5"/>
    <dbReference type="GeneID" id="37111788"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000870">
        <property type="entry name" value="WD repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001043">
        <property type="entry name" value="WD repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="76"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY95070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="375" mass="39638" checksum="896150F14165B132" modified="2018-10-10" version="1">MAPPRRNLLPKDRFAHAFGGLKTQNYHDPASRGPGSHTIRTIAWNPTGQLVATGSADRTLRIWNPERSQVKYSTELRGHTAGIEKVVFNPVRDSELASCSTDGTVRLWDVRSKTCVSRLDVGGEAFTLSWSADGSVMVVGRKDDTLIPISVESPSTPTILSDGTTTTTSITQQKPTLTPSSTTYKALEPHPQPIQTNATTFSHHVSTPSSPDLHLFATTGEGTVKLISYPSFDVLHTLHAHTSACLSISLAPTGRYLAVGGSDALISLWDTTDWICKRTVSSNNGGAVRGVSWSFDGRFICGACDESGCGGNGLEIFHAETGESVYTVPTGGNVNSGIPAVAWHPSRYWLAYSTSADGSGPGGLKIVGAAGGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGW8</accession>
    <name>A0A317XGW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA (cytosine-5)-methyltransferase 1 replication foci domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_552221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473399.1">
        <property type="nucleotide sequence ID" value="XM_025613588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGW8"/>
    <dbReference type="STRING" id="1450535.A0A317XGW8"/>
    <dbReference type="GeneID" id="37115731"/>
    <dbReference type="OrthoDB" id="5382953at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="65958" checksum="95564C012157615A" modified="2018-10-10" version="1">MTSREDSVLAARDSSLFDENDWEEFSLSEVRVLVPGKSRYANLLTASPDNPVQVTGCLDEVEEEQESLVLDPEYLSKRIVLDNVTHFAYGQHNDGEVGFWVAGRAGWFSISPAKGYKPMFNDVVEAIDLLYFLADRHQSKRKRRNWNPSVEYLCEEYVSHTHGICEDADDSAEVFYKHHHFLLSRMLKGEENPQWTSTNIFEHLCEKFSDDYEQIKAQYEGVKEVESEEEAEAQEEEEAEEKEEETSHESDQTGLSKGQADAIYQVILDLKEAGYLAKRQLTLELLTSTLVDRFEIDSAEYAHDLVASRADAILELMDEAKTYNFDWSRKVVYRELKAAGRKSRVQQVTLTPLRPRPSENDGSSGEESEHEDHPRLLRRRVRKSVLRPKSSVATKQTGKRTRSAAADMDDDSDENADAMDEFETPSKVRGHDLVRDPLSTRAKRRTRSILSESVSTYQKTPLQETLQSRNTSVSVADHDTNADASELEIPHGDGVLPDTWVCQVRGCEKVIHKSNSKRGKEMIQDHSLAHADDTKAKIDLVFAEQKLNIGLPVDNLLTRIREMGAFDAELPVDAANGTNGIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UW16</accession>
    <name>A0A317UW16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_570370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000057">
        <property type="protein sequence ID" value="PWY65646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461482.1">
        <property type="nucleotide sequence ID" value="XM_025614804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UW16"/>
    <dbReference type="STRING" id="1450535.A0A317UW16"/>
    <dbReference type="GeneID" id="37116947"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY65646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="330" mass="36405" checksum="16E9B3FA28DD6B5A" modified="2018-10-10" version="1">MSFLSPAVVHEWTQTAVASLPPPAQQALLHPLVPKAIGAVLALTALRQTNRVLNTLSLNNLGSRTWNNNRELVLVTGGCSGIGKQIMTELSSQGARVIILDIQEPSFKLPPNVTFYKADITSSTALHPVAEQIRSEHGHPTVLVNNAGVGHDGTILEEPEAKIRQTFEVNTISHFITVREFLPAMIERNHGHVVTVASMASFVALGEMIDYCCSKASALAFHEGLGQELKYWFKTTGVKTSVVHPFWVRTPMIQQLTDAGNEFKQPVLTVERVGNAIAKQILSGKSGQVILPERYWVASLVRAFPTWMQERVRALASADLLHLREWQQKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UW35</accession>
    <name>A0A317UW35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_504733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000057">
        <property type="protein sequence ID" value="PWY65629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461465.1">
        <property type="nucleotide sequence ID" value="XM_025609518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UW35"/>
    <dbReference type="STRING" id="1450535.A0A317UW35"/>
    <dbReference type="GeneID" id="37111661"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY65629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="653" mass="74327" checksum="77682ECDF4DE463F" modified="2018-10-10" version="1" fragment="single">MAAPIDRQEIDRVLRLKRNQREARACYPCRQRKVKCDNTVPCRTCRRRGHPQICVYDQDLSGSKPARNAGQQRRSTAPHDLTRTPEGPDLEPQIQPSVRSQSETQSQPRQYYAPRIPSSDGPDNDLVYSGDNSVVSILRHQTQDTNGSMAREVGSVLGLQNTYGSYPFMEFRTPQDRWKELVRILPQRAELLKFFHFYRISAYPFNPIIIDIERFEQDVCSYLNSLAAGELQDTAQISERWATDRSVGLISLLLATLASGAHYSDLDYIQRSELCQDFARRSFQALRLANFLFRPTMDIIQALLIVGNTLQNSGQSDAAWALLGTTVRLAQTLGLHTEKSVAHLPDHLKSKARRLWFTVVWQDCLLCLCYDRPRVVSITGWAPDYSILSRSDLSYTEAMYFLCRIALGMITTDGLEIQQSAQQLDILTTIDSLYQHTQPHLRDRQDCKTLHHNLEHMALKMHVSLAISVLTRPALKRTAVRDSSYDILRTRAKMSLIDASRAFLDFQALSVVPLRSWSMVHTVLSSTLLLCIWEETRNDAECRDLQQKVIEVFSAAGSGTVENSTSENRQWLSERHIRALITLRNAVRTAVDREKEDGNVGTERVEQLESFVPAYGMPNGFPDDFGQDFSPTTYLDSIMNVPLFDLSKELDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXK5</accession>
    <name>A0A317UXK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_528599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461673.1">
        <property type="nucleotide sequence ID" value="XM_025610429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXK5"/>
    <dbReference type="STRING" id="1450535.A0A317UXK5"/>
    <dbReference type="GeneID" id="37112572"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_6G13830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY66475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="263" mass="28029" checksum="763E4C2887004BCC" modified="2018-10-10" version="1">MVLFKPNDAPVQKLFDLTGKVVAITGGGRGIGLTVATAYAEAGAQVAILYRTTTTAPKTAEDLAAKYNTVCRAYQADVTIPTQISAAIDTVVLDFGKLDVIVANAGICSEHAGEQYTPHEFQEIMDVNVNGAFYTAQAAARVFKKQGFGNVVFTASVSATLVNTPQRQAAYNASKAGVLQLAKSLAVEWVDFCRVNCVSPGYVQTQMMQYASSEMQGKWLGQVPAKRFASPYELKGVYLFCASDASSYMTGSNLVVDGGFTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYA4</accession>
    <name>A0A317UYA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_422707</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000065">
        <property type="protein sequence ID" value="PWY64970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461345.1">
        <property type="nucleotide sequence ID" value="XM_025607417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYA4"/>
    <dbReference type="STRING" id="1450535.A0A317UYA4"/>
    <dbReference type="GeneID" id="37109560"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY64970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="148" mass="17017" checksum="0C78C89F5AD68A65" modified="2018-10-10" version="1" fragment="single">VSTQPYVFEYDGSFQDEQSPDTDENWTRLFPQRKGFFQHPTLAKQRSAFAVFHQLHCLNSIRQGYWALYDIAATDRNFPGDENLPEMSSPHHVRHCLELLRLALMCQPDLTVELKNETLGGVTGFGTEHQCKSWADLSGFMAEWESYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZ70</accession>
    <name>A0A317UZ70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_503967</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461797.1">
        <property type="nucleotide sequence ID" value="XM_025609495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZ70"/>
    <dbReference type="STRING" id="1450535.A0A317UZ70"/>
    <dbReference type="GeneID" id="37111638"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY67075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="493" mass="53463" checksum="44E60C0695EFD093" modified="2018-10-10" version="1">MAAQADLEKAALPATVQSSPELDNAPQPHDANIVDYDGPDDPESPFNWPRWKKGRQLVLMAFNTFITPLASSMFAPGVEGVMKAFHSSSTMLASFIVSVYVLGYVIGPFLIAPLSEIYGRVPLYHVCNVLFLIFTIACAVAQSMPQLIVFRLLAGTAGVCPLTIGSGTVADMVPKEKRAGIMAIWAMGPILGPVVGPVAGGFLAEDEGWRWVFWVLAIATGLMTILCMIWYRETYAPVILERKAARLRKETGNPDLRSVHDHGKQTSEVLLSALARPIKLLVKSPIVLLMVLFAATTYGYLYLMFTTITSIFEDVYGFSTGLAGLAYLGFGIGCLIGLVVTGAVSNRIAKSHSAKGCFTPESRLPPMIFGCWAIPIGLFWYGWAAEAQTHWIVPILGTGVFAIGLMTVFMSASTYLVDSYLRYAASVTAANTGLRSLFGALLPLAGPSMYDALGLGWGNSLLAFIALAMCSCPLFFWRYGARIRTHPRFQVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZU3</accession>
    <name>A0A317UZU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Rad4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_540729</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461552.1">
        <property type="nucleotide sequence ID" value="XM_025612978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZU3"/>
    <dbReference type="STRING" id="1450535.A0A317UZU3"/>
    <dbReference type="GeneID" id="37115121"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="517"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="576"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="646"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="761"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="913"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY66042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="922" mass="103518" checksum="B60AAF124A49DCEE" modified="2018-10-10" version="1">MPPFVPRKRLSSEDPPAAKRHHATPSIAAVVPDTDSESSLSDIPEETPLVQDGSDEESSGSDEVDWEDAIETNPPSATPMTPSILTRDQHQDLELTLDKNEIHLSDLLEGKKGPSKIERQIRIQTHCLHVQFLLHHNAIRNAWVNDTQVHETLLRKLLPAIHQEVKKWRIASGLEVPEQPPVKKSKKGKGKQRRQSDRDWAEGSSRMEPGKPDMSGGDPIILLLKVLAAYWKSQFKITAPGLRKQGYRPMAQLEAQITSLHKDNHDPGKHGEKIADIEEFRHAAENMQGSRDVGAQLFTALLRALNIEARLVASLQPLGFGWTKAETYTSKPRADTEPSIENAETETAVDLESDSSEEDTKPTRSKNSKGYDKDLPFPIYWTEVASPVTHQIIPVDPLVLRNPVATTPDLQAAFEPRGAKAERAKQVICYIIAYSADKTAKDVTTRYLRRRTWPGKTKGYRMPVEKIPVPGRKGKFYEIDWFRVIFRVYQRAPPQRTAVDDIEDAKDLLPNQPERKPAKGDTLQSLRASTEFVLERFLRREEALKPGARHVRTFATGKGAKAKEEKVFRRKDVLKCQSAESWHKEGRRIKTGEIPLKHVPIRAVTLLRKREVDEFERENGQKPKQGLYAKHQTEYIIPPPIRDGIIPKNDYGNIDCFVPSMVPRGAAHIPWPGTVRVCKKLGIDYAEAVTGFEFGSKMAVPVIQGVVVAMENEDLVKDAWRADDAEKRKREQRKAEARILQTWRKFLFGLRIAQRVREEYGSEEHEHDVHNPFTNRRDQLSASRSAPRPEDHDSDPAHQGGGFLLPGEDEHPVDHGGGFLLPGEDNDPADQGGGFLLPGDDGDDDGGLIVDHHEHQQPQHRQPNSPQIQTVHAEVDDSHDDPISLSSDSEALSSPIEIPGSEGSEPEYVPPTTRRRTRRGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V1Q3</accession>
    <name>A0A317V1Q3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461928.1">
        <property type="nucleotide sequence ID" value="XM_025612905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V1Q3"/>
    <dbReference type="STRING" id="1450535.A0A317V1Q3"/>
    <dbReference type="GeneID" id="37115048"/>
    <dbReference type="OrthoDB" id="5355007at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="212" mass="22825" checksum="856DB5F3893F0A8C" modified="2018-10-10" version="1">MPSSSSPSHPTTTTPHPEALESDLLHHLTSTPVLEDLHSTLLSSLQRLGWTERIRKLAQELLRGGRCERFDEVFEAVIASAEGRRHPILIEANKAKQSANANTNTNTNTSNSQTTNGINDDDGIENFETYDVRIPQAVVDQGVRAIKEVLRDVVVTDDGGDILGDVENGHIKEEGGGSGGGATEKVKGTKNGDTASPVKKVEKKPKTGKQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4E3</accession>
    <name>A0A317V4E3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 15">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 15">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_540004</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 15">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 15"/>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462359.1">
        <property type="nucleotide sequence ID" value="XM_025612820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4E3"/>
    <dbReference type="STRING" id="1450535.A0A317V4E3"/>
    <dbReference type="GeneID" id="37114963"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14291">
        <property type="entry name" value="UBA1_NUB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000144">
        <property type="entry name" value="Ubiquitinyl hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF10">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 15" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="151"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="302"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="582"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="644"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="730"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY69154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="776" mass="86643" checksum="5CD5200CED4C9B83" modified="2018-10-10" version="1">MACSHVSSQELREPTTSQVVYREDCTQCFDSIDEDHGLNVCLTCFNGGCAGDRNHALLHFERLGHPLALNIKRSRKEVQRDEPPHKISKLAVAAETDEDRYLTKTHVICYSCCQDGVDASSGKLPAVIDGVMKAMTFSKREEVKAWEQEFIPCEHTLGLVQRESRQIESKDLVQCSMCNLKENLWLCLECGNLGCGRSQFGGVGGNSHALAHSDMESHHAAVKLGSITADGSADIYCYRCNEERTDPNLATHLANWGINLAGREKTEKSLMEMQVEQNMKWEFSMTSEDGHEFTPVFGPGLTGLTNLGNSCYLSSVIQCLFDLPEFQRRYYHPDEKPPLSEKPAEDLETQLRKVADGILSGRYSRPDSNVKASPDSAEVPHQRGLAPAMFKHLVGRNHEEFSTMRQQDAFEFMLHLFKQIGLSKHPEGLDNPIASFRFSIQQRLQCLQCRKVRYKIDEQDNISIPVPARRISADDTSSTNNFESVTLLECLDAFTADEVVELSCPSCGGTDGFKKHYSFKTLPQDLVINARRFELINWVPTKLDIPVEVDEGPIDLGPYLSPGPEKDEELLPDIEAPESLFKPNETAMQQLLAMGFPQPRSERALYMTGNSDPEAAMNWLFAHMEDPEVDEPLDMVQANSPGDQQDPAKVAQLAEMGINEVHAKRALAATGGDVNRAIDWVFTHPEDSMEIRADTHGTGGACMLGFDTIPARYQLRSIVCHKGSSVHAGHYVAVVRKALPGRSGSSWVMFNDEKAVQVDDIQEMKKFAYVYIFTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5N3</accession>
    <name>A0A317V5N3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_569663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462431.1">
        <property type="nucleotide sequence ID" value="XM_025614748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5N3"/>
    <dbReference type="STRING" id="1450535.A0A317V5N3"/>
    <dbReference type="GeneID" id="37116891"/>
    <dbReference type="OrthoDB" id="3549294at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY69603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="493" mass="55504" checksum="09F1954A30BC4D0A" modified="2018-10-10" version="1">MKDAVPSAEEGRTVYEKGFRIWQSLYMRAMERSDLPQTCFQIQPALQHQPYFPDDLNLKLAYKKLWASGTSIWEGSSENCTIPPLQRHVQIGVSADIPTPLIVSTNPDRSHQQWFNTDENHLTVLIFAWSHILSARWAELMPEAILTYTDSKACNSDKAENKILSCNRCMVSDTAISAATAFGFLSDYCSLHKIVDQGYAALSAVLLLPQLPGRGKGIEDHHLDKLLTLSCTGGAIHSLLASVFYEPGIACNVASPWLQSIFAVVNSVDDDRILIHMLMSRVPHLAFFWLGGAILGSHKQVLRDGQFGFIPTDIDVAAWSGTMQSFMQEPIHPATNSSILRSDKCRILYLIQEDRHTRWPICPWMPFGATALENTEIDVRLHANCTGHGLRYAGWKWTCQNGRVVEPIMPNITINYDALNPGEECESKNETRCMFGWLRREGYPPQEKRIHEWIELNGLDGRLSPDKDSGEGHKASRTDVEDWIDHIVCDDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6H3</accession>
    <name>A0A317V6H3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_477670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6H3"/>
    <dbReference type="OrthoDB" id="3868412at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15838" checksum="43C69EBE4C176918" modified="2018-10-10" version="1" fragment="single">FLVLSTTYDHRVWRTGLPVRSAVLKPHAGRLVVGWVTTSESLLLYVFVPSFLFLFSISPIISFFHYLFVFKLIHVMTVWLHLYARLNRFCVWWDGASWFQNATQYKVCITHHISIIQLSSRIEHPIDHYHGYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6X7</accession>
    <name>A0A317V6X7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_628603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462326.1">
        <property type="nucleotide sequence ID" value="XM_025617493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6X7"/>
    <dbReference type="STRING" id="1450535.A0A317V6X7"/>
    <dbReference type="GeneID" id="37119636"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000255">
        <property type="entry name" value="Alpha/beta hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="28"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="301" mass="33118" checksum="565673856B3FE914" modified="2018-10-10" version="1">MADITITEGEFKLPDGTVLYQKTWSPATPKAKLAHFHGFSDHINNYNDFFSLLARHGILCSGIDGRGWGRSAPKKSDRGNTGPTSLTLADMAAFIESQKTDVFPELPLFVSDHSMGGGLVATFASTPKYQPLVSSLRGILCLAPLMGLTPEQTPSSVTVFLGRLAGKVLPRFQLVEKMRVETLVRDPEVQRSLKEDPLNHATGTLEMFANMLDRMIALDEGKLVLVDGVQSVFLAHGTGDNCTSYDASKRWFEKQTTRVPETEKLHKSYDGWSHLLHSDLPENVPVYADDIATWILGRSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V728</accession>
    <name>A0A317V728_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_539893</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462523.1">
        <property type="nucleotide sequence ID" value="XM_025612797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V728"/>
    <dbReference type="STRING" id="1450535.A0A317V728"/>
    <dbReference type="GeneID" id="37114940"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY69825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="92" mass="10290" checksum="843293FCCEEB452B" modified="2018-10-10" version="1">MTRAQQTLSVLLLVSSLYLVLYLGLVPLNETVQTEIIPVLPFYALICFGCYLLGRLGLAILTFNDVPEAHEELQKEIEQAKAELRKANVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7B4</accession>
    <name>A0A317V7B4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_478663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY68030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462079.1">
        <property type="nucleotide sequence ID" value="XM_025608700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7B4"/>
    <dbReference type="STRING" id="1450535.A0A317V7B4"/>
    <dbReference type="GeneID" id="37110843"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY68030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="56286" checksum="C192BC1A235BE7AA" modified="2018-10-10" version="1" fragment="single">RVRKIKCDETPGACVRCTSTGRRCDYDLNRLPVIARGRARPIWPQKCPRMLPVQPGASTDERRCFEIFTAHTVPMMVCWFDSEVWQQIVLQMSHAEPAVYHTVVALSALHEDGEVTGRPPSKLDLTNRHHRFALEQYGKAISLLRRRLTSQDPQVRELALMCCINFICFELFRQNYGNAFIHLQNGAKVLDYHLNTSRTLLGANRSSTVRLHRARCVSRTEMALTKVFVHLDAHSAQFGQEGPLLNLPLGVDGNNVRIRSVLDAKQQLDPILSNILRFRRSCEPLLRGARNGEMDMVTAIAEQAQIRGWMMAHMAAFDHFMRDQVISTLSRKERRGVDVMRMQQVALLNILDTSLVTSEMIYDGYLGEFQTITRLAEGIIASFYAEHGRRRTTVAIDMGVIPSLFWVCLKCRHRATRQRALALLELWPHREGAYDGRVMVTLAREHIAMEDQVQAVQGEWVVIPEWARVGSVDRVESADDDAEDCNNGPSEAFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V938</accession>
    <name>A0A317V938_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_539743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462778.1">
        <property type="nucleotide sequence ID" value="XM_025612765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V938"/>
    <dbReference type="STRING" id="1450535.A0A317V938"/>
    <dbReference type="GeneID" id="37114908"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="37"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="462" mass="53570" checksum="6E1DE2432FF5117C" modified="2018-10-10" version="1">MQGRRQVVPKRVIFVGTDHSDQLQLQESAHITQPFDYITLSHCWGKPTDEEMEQFRTTRRNYQERLEGFSYHSLPKVFQDAITVTRELNKQYLWIDALCIIQGDQKDWEEEGARMDKVFASAYCTIASSSASGWNDGFLNRTQDLCQSEVVNSDQKIVDDFCKLVDEGQLHTRAWVLQERALSRRTIYFTAQQTYWECGEGVRCENFSTLECPITRLYLLDPRFPERLVFAGYKSAALFLQELITDYSRRDLTFPKKDKVVAFSGIAERIKEALATEVRYGVFRCFLPRLLLWKRAGMENDRIYYDDDRVPSWSWMLYNGKIDFLTQSDLQVPRNQSLSFDNSERGINIEVRQFEGCYTRERDGEHIIFTKTKKVEVTTEVEATKEVEVGILHFDMGSAAEVESRNCVVIAMCQDDDKDDPNKDYYILAVQRTSGEEEYERLGVGRVRACYVSKGSTSGKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VAK0</accession>
    <name>A0A317VAK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Calcium binding modulator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_539859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462680.1">
        <property type="nucleotide sequence ID" value="XM_025612793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VAK0"/>
    <dbReference type="STRING" id="1450535.A0A317VAK0"/>
    <dbReference type="GeneID" id="37114936"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048306">
        <property type="term" value="F:calcium-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051426">
        <property type="entry name" value="Peflin/Sorcin_CaBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212:SF3">
        <property type="entry name" value="GH27120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46212">
        <property type="entry name" value="PEFLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY70389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="322" mass="36005" checksum="A0C74ACCF066D2A8" modified="2018-10-10" version="1">MAYNQSYNPDALPAHAEPEQVAQMIGAMQSSSGHQQKPRPPPHSTSSGIPPRVPVSGAGNLSPHPQRYGAPGQRPPMEVAHGKQSPTNVPPASQHRPHPLHPSPPPQNYGFGPPPTQPVRNRPPVARPPNSPHHAAMAVPDDDPQQLFPLFRAANTSHSGSLTELELGSALVNGDFTSFHPNTVKMMIRMFDRNNSGTISFDEFVALWRYLAAWRELFDRFDQDRSGRISLHEFENALVAFGYRLSQPFVMVLFRTFENKGRQMNGHAYGPAKQGMSFDLFVQACISLRRMTDVFKRYDDDRDGYITVSFEEFLTEILQLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCA0</accession>
    <name>A0A317VCA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_261145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462794.1">
        <property type="nucleotide sequence ID" value="XM_025606495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCA0"/>
    <dbReference type="STRING" id="1450535.A0A317VCA0"/>
    <dbReference type="GeneID" id="37108638"/>
    <dbReference type="OrthoDB" id="18110at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524:SF1">
        <property type="entry name" value="MRH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23524">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY71039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="547" mass="57421" checksum="065DD49B9ECE27EF" modified="2018-10-10" version="1">MASPRTLFTASRLQTWTYLLGVCPFSIAFLVFINSSISFVVTELIGLRDGEGDAVGTLGFADELLALIACPLWGVLSDRIGVRHVCTTGYAIVALALILFVQAKNVYPQLLLGRLLFSLGGAAVSTMVTAVLPAVAGSHSAQHKPASESQKNTASSSRLAGFVGMCAGCGALVSLVVFLPLPARFQQWGLSPAEAIQRSYYLVAAVSLVISAVCFFGLRNLPGEEGKSWSSLWSARRRGAPDGGDSCPYAHKFQLPYLEQLGTAFALGFQNSDIFLGYLGGFVARASSVGISLFIPLAVNHYYRQSGLCGSQDGEAASAGDIKKSCHRAYVLASILTGVSQLVALIAAPAFGYLSDRSRRRHVPLLAACLVGLVGYTTFALLPSPEFNGDHGSPGVFVVMGLVGVSQIGAIVCSLSVLSSGILSMSDASSMEDQFWSEQSDPSEDEEEDCPVTAAEEDEDRPLMAHRMGRKGRHLAHLKGSIAGVYSLYGGAGILILTKLGGLLFDVLSSGAPFYIMAGFNGALLLAGLVSGFIGHSRPAAPAGYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCM2</accession>
    <name>A0A317VCM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_477068</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462711.1">
        <property type="nucleotide sequence ID" value="XM_025608626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCM2"/>
    <dbReference type="GeneID" id="37110769"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="691"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY70817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="785" mass="88984" checksum="1F70A75D866DC378" modified="2018-10-10" version="1">MESKSASVSPELEIPTSYDEKKSSQDSPMEPQMLEKGQTVHIGEDSEDFDSDVVVSTAQDLVTHIIKVEDDPSLNPWSFRMVFLGAGLSIFGGVLQEIFYFKPQTIYVSQVFLTVIAYVLGEAMAYFIPRRGYIGRLLNPGPFNAKEHAAISLMSSAATQSALATEALSAQQLFYGGYPNHAAAVFIVLSSQLIGFGIAGLLRDVIVRPTKMIWPMTLPITSLLESLHKDKTEAKARMKIFYIFFFILFFWTIIPEYIFPILEGFSIFCLADQHSLVFTNLFGGASGNEGLGFLSLSFDWNYIASLGSPLWYPLYAMTNNFIGYLFCIILFMAIYYGNIWRSQDFPFLSQLLYYGDSNSTYYHQYNQTLILNSEFIVDPTALKEQGLPWLTGTYVVYLITSNMGLTATITHMLLWDLDDIKVGWAWAAPSKLKKFLKPETYKFWANQETPEERLARRVNDDTLDPHYRLMLRNLYQDTPLWWWGAVLIASFAVGLGCLYAMKSTLPWWGFIVGNIITLVFMLFFGAQYGLTGFQFNVQPICQMLAGYMFPGKPLANLYFTCFTYNSLQQGQVLAKDLRLAQQVHLSPQCTFFVQVVGCIIGALFNYVMMLIIVRNQSEVLISIDGTNIWSGANVQITWSIANDMFSIGGRYQWVTISYLVGFIVPVPFWLANRFYPHPIFSYLNTSIILWYMGWLFVGINASILSYFLLGFAAQFWLRRYHPQMFNKYNYIVSAALDGGTQICVFILTFAVFGGSGTEHPFPTWAGNPNTDIHNLDYCKVNPATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCS6</accession>
    <name>A0A317VCS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_267582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462771.1">
        <property type="nucleotide sequence ID" value="XM_025606536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCS6"/>
    <dbReference type="STRING" id="1450535.A0A317VCS6"/>
    <dbReference type="GeneID" id="37108679"/>
    <dbReference type="OrthoDB" id="4368687at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="92" mass="10444" checksum="B0EB6C06973176BB" modified="2018-10-10" version="1">MTEAFGWVSDVCIFAISRTYATNKQLLEKAPSRANRWSWRESSRFAPDKLELFNFKNPNAPRLTIIFPTKPRQSQTVHGGSQTNRGAMIASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNU1</accession>
    <name>A0A317VNU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464010.1">
        <property type="nucleotide sequence ID" value="XM_025612489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNU1"/>
    <dbReference type="STRING" id="1450535.A0A317VNU1"/>
    <dbReference type="GeneID" id="37114632"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="99"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="598" mass="67163" checksum="13FF22B9F72D786D" modified="2018-10-10" version="1">MQSIRGRLLGRPLGAALSRRCNTPDPLLAASLISGNSNINETKGIADSKHGLGALNRTTSSRWLWNEQQQLASRSVKFDLTALLQLAAAATASRSCTQVSKISDGQYNKVYQLTMDDGREFIAKFPNPNAGRPHLTTASEVATMDFLGNALNIPVPRVYAWSSRASQSPLGAEYILMEKLPGVVLTDVWHTMKGKQKVKILDQIVDIERRLARTRFTKFGSLYYRDDLPNSPDPKRTLYHDLMGNQVGTKTFAMGPTNHPSFFDFGRGQLTIDRGPWSTLTDYMTAIVQREIESAKSGFRYPLMPEGLFYGPRQYQPTLSKKLSALENYLKVAPDVLPEDKTTHVSVLWHDGLHSQNIFVDSEDPSRIVGIIGWQSVSACPLFMQAGRPAFLDYNGPTPKDLGKVPLPPNFDSMHPDEQRKAKALRLAQTLHNIYLDRCLQQNKPAFEAIQGQNTLQHQVSVAPGLVSMDYEPLLNSLLRDVEKEWAHIDAVGNNDIPRGTPFPLRFSDEEIQEQERDGELWAQGVELMDAFVGDTGCFKHWDGRVSDADYERSRKELDEGVERFLDREARNEEERMEWLKSLVFVDQGNSQGEGDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNY0</accession>
    <name>A0A317VNY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF500-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_538468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464071.1">
        <property type="nucleotide sequence ID" value="XM_025612496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNY0"/>
    <dbReference type="STRING" id="1450535.A0A317VNY0"/>
    <dbReference type="GeneID" id="37114639"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11524">
        <property type="entry name" value="SYLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF8">
        <property type="entry name" value="DUF500 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="162"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY76074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="431" mass="46750" checksum="1839200D53FE76C1" modified="2018-10-10" version="1">MSQQPPTTAGSSMWGKTKTYGKMGFDKAWGALDKLGGPVNRLSNKLGSEAFWPMTLDKESEKVARILRSFCKDGVYVDETATEAPPPPDEKNGAKPKIDKPRGQQKVLKKIPSDVIRQAKGLVIFTAMRTGLWFSGAGGSGILISRIPETGEWSAPSGILLHTAGLGFLVGADIYDCVMVINTYEALEAFTKIRVTLGSEVTVAAGPVGMGGVLESEVHKRRAPIWSYVKSRGFYAGVQIDGSIVIERTDENERFYGRKIPAKEIIAGQARTNNPSVRMLTHTIHSAQGDANFDQAPAGVQMPTGPSPSDYAPEDLQHTPMVQTGAAPPEGAQYQQHQQYPPLGGHYQQFQQYSPAPSAQPQQYQQYNPGPAGQPQEYHQGQGVQSQPPQHNPAAAGQYQQPQQYPAPGGQHPQSQQYDQGSGAADSYYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VP65</accession>
    <name>A0A317VP65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_589005</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464150.1">
        <property type="nucleotide sequence ID" value="XM_025615922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VP65"/>
    <dbReference type="STRING" id="1450535.A0A317VP65"/>
    <dbReference type="GeneID" id="37118065"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY76153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="476" mass="53905" checksum="D0361C1FD6B52A13" modified="2018-10-10" version="1">MTEAEEGTTKVSMPYRAVQVCSTCKLRKKRCDKTLPICGYCGKRNLLCRYEDFPQPKGESDAVAAMLMQMVSLLGPSGSMSTSHRIWYQVQRIIQFASLSLQEIGRCYFNNFHKWLPLISYQVYEEEVTAYNWMSCPPAADFSILTLAMCLITLQPNRETPITPQGLYGTVKVLFAETQAMMCAPDRLLQASLLIAAYEYANGRPEAAHITMGTSSRIAFGIGLHNTDFEQPFSVGDRVRIEERRRCNLWWGGIILERLIICEIKDKEQTPITEYPPPEFPLPTDLDCDGMDSPDADQIAQISSFGRQAQAVFLLDQVLAARRLPLTDKCKMLELRRLDRHLQDFLSMLMSTTTAKIGHDCGPIAPAVRALSLIHQEILDYSPDTVDMRCLHYSQSALEMITNVVVDVARHHKEQIACENARVDLLPLSCSYTLHLAMKNTRDCLGISCPHRHPSDLESLDQLDRVFSNRWKAKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSG7</accession>
    <name>A0A317VSG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_196827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464511.1">
        <property type="nucleotide sequence ID" value="XM_025606077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSG7"/>
    <dbReference type="GeneID" id="37108220"/>
    <dbReference type="OrthoDB" id="5416097at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="17"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY77324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="272" mass="31031" checksum="42A1A5900FF4D2BE" modified="2018-10-10" version="1">MRSFSAVKHCRLRDRMCVVTKDREENCDVAHLFPVYMQESESPVTKTFWEGLERFWTNDQVLRWKSALSDETGGTERLENLVCFAPTVHRYHSRGYFALEFLAKDPGNTWLRLKLVWLQPQKPFGHFPLERVPELPEDLNLPALGFGLMDIKTQRPIFSGHIIELKTPDPIKLPLPDTRILELQWLMNLVTPISGAAEPEELDEDTDNDNRTRSDPSKFPVSSSSIMNESISSPTTSLSGPTNDHPKTPTTMTTNVEDSETLIDQEEDTFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW92</accession>
    <name>A0A317VW92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_549076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464449.1">
        <property type="nucleotide sequence ID" value="XM_025613427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW92"/>
    <dbReference type="GeneID" id="37115570"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY77262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="215" mass="24344" checksum="8F9FEAF03F3D6710" modified="2018-10-10" version="1">MALIGNSFRPYLYKRSPCSGNILLWSEIEDDSPLPRRKFDPPDPESIVRHRTQCAINRNSSSIFRTVKVVRLVKACRDGLLSLLLPVHRTLMYEATILWLVLASRGKCNNSSPVSSWLLGVFWVRWKGVSKDDSRSYEGASDSTRETHGTSRSLQEMGALCAEAFHDHPIEALFEHSRHGRYRSPHDEADIVGSYLSMKLRVVLSNIMATVISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYM7</accession>
    <name>A0A317VYM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_537846</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464579.1">
        <property type="nucleotide sequence ID" value="XM_025612364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYM7"/>
    <dbReference type="STRING" id="1450535.A0A317VYM7"/>
    <dbReference type="GeneID" id="37114507"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="8">
        <location>
            <begin position="24"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="201" mass="22088" checksum="A9680EA2C4A0DD05" modified="2018-10-10" version="1">MEQIYLHSLPVKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAVVVIGDSEGHIGLGIKTSKEVATAIRAAIIIAKLSVLPVRRGYWGTNLGEPHSLPVKQSAKCGSVSVRLIPAPRGTGLVASPAVKRLLQLAGVQDAYTCSSGSTKTLENTLKATFLAVVNTYGFLTPNLWKETKLIRSPLEEFGDVLRQGKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W068</accession>
    <name>A0A317W068_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_182725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464877.1">
        <property type="nucleotide sequence ID" value="XM_025605983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W068"/>
    <dbReference type="GeneID" id="37108126"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="244" mass="28110" checksum="FECDCC30FE90A245" modified="2018-10-10" version="1">MAPIRRYLRISSHTILECRIYLDNPSDVRWLLNTRGADPILPRIFAAIRPLVHPKLREENERLLFGKKTKGRVVKDVVSEEDFEVALFLRESRTRHSLLTREKVFGDADGEGRRAGGEGEILIESDDEDHGVGVQMQDIPHASDMDQDKRVGTKRQQAVDDSPERQRVSKRRKDEEFLPQVAEEDKKMRFRTNYEGFNIYGWVLCLLVTRKGDRTGTKAPAEPGRQVLMEEWISTQAQGDLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W0T3</accession>
    <name>A0A317W0T3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7709 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_537142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465123.1">
        <property type="nucleotide sequence ID" value="XM_025612199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W0T3"/>
    <dbReference type="STRING" id="1450535.A0A317W0T3"/>
    <dbReference type="GeneID" id="37114342"/>
    <dbReference type="OrthoDB" id="2359405at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056126">
        <property type="entry name" value="DUF7709"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24813">
        <property type="entry name" value="DUF7709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7709" evidence="1">
        <location>
            <begin position="7"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="108" mass="11863" checksum="4BCA23B7D0003E8C" modified="2018-10-10" version="1">MTSPTADLVALNSSTLGTAMPEVTLPDGSKVQTGTVGALLINIRVYNEAHANGNRDKMETLRTALRTAIPLLQKVGMFDLFPPEEWIQGDNEGRKLVGRIYQEFFELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2M2</accession>
    <name>A0A317W2M2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chromosome segregation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_626471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464739.1">
        <property type="nucleotide sequence ID" value="XM_025617359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2M2"/>
    <dbReference type="STRING" id="1450535.A0A317W2M2"/>
    <dbReference type="GeneID" id="37119502"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000790">
        <property type="entry name" value="Chromosome segregation protein (SepB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="11"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="417"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="726"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY78430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="840" mass="93998" checksum="226BB98F92D1B831" modified="2018-10-10" version="1">MASEAMRPRGRPAHTPGTTVLAYTPDGRRVITGGSNSAIRIYTVGQDGEPKTIDEGVDGHLGIGATNESFIMGAEDGTVWQYEIESGRMEKLLVRCALPVRDIAVSTDGEWAAVASDELTVKIVNIEDMTKVKYLRDQAKGTKHVTFDPSGRYVTVSCTDGMLYIYSILSDEPELVRKLDGVIRRLEPEDEATSRIAWHPDGTAFACAEATRDIAVFSVGEWKKEKVFSGGHNGDVTAISWSPNGALLATAGADGQVLLWETKTQKVLERYDFANVINLAWHPTNNSLSFTTSDGELFIYDGIVSRDHQPLLQKPLQAAPIFSGPLTEISDNVRRPLANRPKESIERRERARTPDSLDDVLNYDVGMEDFVDDDDGAGYAEGVNGLGKRAGSHLDDIDGHADKRLLTSFAKPKVHAPLQPGSTPWRGNRRYLCLNLTGCVWTVDQETHNTVTVEFYDRELHRDFHFTDPYLYDRACLNEHGTLFSNNPTDDSPATIFYRPHETWTTRADWRTQLPKGEFIRALALSDSYIVAVTTKDYVRVYTLFGTPFKVYRQKSPAVTCAAWRDYIMTVGNGPLGSDGRTATLRYTVENVKRDEVCQNEDVVAIPEGAELQSVFFSDAGDPCIYDSEGVLLVLQHWRNNGQARWVPLLDTKQLERLASGRKEETYWPVAVAQDKFHCIILKGGDKYPYFPRPLLSEFDFRIPISDMPGKGPEEEEEEEGREGARFEEAFVRGSIMLSLFEDLLSSTNATTGQRAELARKELEVDKTLLQLLAVECREGEERGMKALELVQMMRDRNGKMVEAAVKIAERYGRGVLEDKIRDLAERRYMGADDDDDELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5V9</accession>
    <name>A0A317W5V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_536935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465791.1">
        <property type="nucleotide sequence ID" value="XM_025612152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5V9"/>
    <dbReference type="STRING" id="1450535.A0A317W5V9"/>
    <dbReference type="GeneID" id="37114295"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY81723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="170" mass="19281" checksum="25445D9DA1C608F7" modified="2018-10-10" version="1">MTNPTSPPGRLLRLTIQIYRNQASTNSEEREKFAREYLSKVAVVVAKHGIEKYQQVYTPPAFREALEESSRRNKRGWVIDDHDLTVEFYFRNFLAMNNVRNDPEFAALQASEGPYVNLIHTVATLGWVEQYVDGGKVVNIGPDGRSMYPSWAELGDVQSMFPPKVAEGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6E7</accession>
    <name>A0A317W6E7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_151764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465484.1">
        <property type="nucleotide sequence ID" value="XM_025605803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6E7"/>
    <dbReference type="STRING" id="1450535.A0A317W6E7"/>
    <dbReference type="GeneID" id="37107946"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY80882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="537" mass="61358" checksum="568C43D8084EE52C" modified="2018-10-10" version="1">MTHLSATVPTKQRKRAYGKRSRTGCRSCRARRVKCDETPGACQNCTSSGWACGGYDSHRLPPAARGKVMPQVTDGFRWAMTSDERRCFSYFQHHTIPTLLEMFDSPLWRKLVLQMSYSEPAVYHAAVALSAVHEDAEGHGFPLPGQARQGTWQQFALDQSLRSFGILNRRHSSQDPKLREVMLLCCLLYVFLELLSGHHENACRHLRSGLQILKEARAHRQLIGASESPVETCLVAAFAELDIQSPFVGAQGMVLCLDDEVDQYSWLASFPFGFHSIFDAQRAFAPFMYGAYGFVAQCWPLTEEQVMANYDALQSEQRQLLSHLIRFADLCEPLYASYLQLSRKEQRGVDIIHAHQRHMVLEVSTCLLPRHSPVRDCFTPHYRAHLGDLKSIIRKAPECPSLSLFPSLLPCLYAIVLSCHDYDVCLEATEELHRWIHCEGMFNSAWLALQAIEHVRLDFLEEELSLGSSSPDTFATVMNEERSHLWSRIEDMRWRITRGRPGYLDEVLQASEYMRTWVCVRALQMRKARLNELLSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W927</accession>
    <name>A0A317W927_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_567349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465820.1">
        <property type="nucleotide sequence ID" value="XM_025614624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W927"/>
    <dbReference type="STRING" id="1450535.A0A317W927"/>
    <dbReference type="GeneID" id="37116767"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF122">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY81752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="269" mass="28880" checksum="B663F9DD856FFE21" modified="2018-10-10" version="1">MLRLDGKIALITGLGQTTDEGWGIGAAIAMKLAQQGAIIFGGNRSLSSAERTKSRIEAEGGVCHVQQTDVTDSASVKALVDSCMQHHGRIDILINNVGKSEPGCPAQMSEETWDQQVDLNLKSVYLSSHFVLPIMEKQETGGTVINVSSIAGLRYIGKPQVAYSTTKAAIMQFTKSTAVIYAGKGVRLNTVVPGLIFTPYTRELAKRYAPGGDEEAYMKMRDDQVPMGRMGDAWDVANATLFLASDEARYITGQMLVVDGGITSSTGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W940</accession>
    <name>A0A317W940_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear localization protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_557799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465911.1">
        <property type="nucleotide sequence ID" value="XM_025613958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W940"/>
    <dbReference type="STRING" id="1450535.A0A317W940"/>
    <dbReference type="GeneID" id="37116101"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="441"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY83126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="76534" checksum="C01D13BF6E4BF9B3" modified="2018-10-10" version="1">MYSTSQSSVPAPMNGIGGELVDGSGTINPAALNNAPLYGGIATPTSIAPRGVKRSRTPDQRGNARADGDHDDADEQGRRKRGRPPKTPRPSTTNTSDQTPSSNIHLHTPRLQTQPLPSPATVNVSPPQASPPDKTTPTKSTLVKALPTVRDHTTDQLNEEGDEYIPKEFDEAGEKKVDAMGYLQGGREYKCRTFRVPLRGTKLFMLATECARVLGYRDSYLLFNKNRSLHKIIATQIEKDDLIQQDILPYSYRSRQIAIVTAKSMFRQFGSRVIVNGRRVRDDYWESKARKQGFTEEDLAGEKRPGGSKARDAAAAEAAGAASFLPALAHGDVIYSNALEAVPNSLPLGPPSSVSLAPPLPMIHMATTTDDPRLREYNSMPRPRQELTGQPYQDRSQPSSAAEILNQASHTADFNKILTSQRSYRQKGLEEFYAKQREIPVSAAQSQPGQLDSTPSVSQPLQSPQIPPTGMMNSAQSQQAMLPHQAPIMPGQSGFQPPAAHQQPPVAPSPVRGVPPVRPELMHQRSNPALAAGTPQPPGPYGYPPQSQQMWGQPPPQPQPSPLSAAGPQGVGMPQFAPQLHAQQSPSPLAHSMPQQQHSQSPRNQPRPSAPPMPQPFPMHPQQAPQQQPMATMGYPGVTAAPYPAVPAARGMYPSTQGPGGQQFMAGTPQQPGMAMGMSAGGAMPGWPPAGPMQPGHPQPGQSGTPLGWSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W969</accession>
    <name>A0A317W969_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cystathionine beta-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_557821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465941.1">
        <property type="nucleotide sequence ID" value="XM_025613960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W969"/>
    <dbReference type="STRING" id="1450535.A0A317W969"/>
    <dbReference type="GeneID" id="37116103"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="385" mass="42069" checksum="B78A0F44DDB78198" modified="2018-10-10" version="1">MAAAETLAEALPTMALATKSIHADDCFSAHRAIAPAMHVAVTYRYARSPNNLIPLENKDPNAPFDSHVYARYDAPNSSRFETVLQQHLGGGILTYATGLAAFHAIMVLLNPKRVFLADGYHGVHAIIEVMNKLTGVQKLTLDQLDEHLRPGDIIHIETPLNPTGEARDLAYYSAKAHAAGAYLTVDSTLAPPPLQDPLHFGADVVLHSGTKYIGGHSDMMCGILVVHPDRVAQGWLDTLYSERMVLGSVMGSLEGWLGLRSLRTLELRVKRQSSTAEKLVAWLDAELQSSESAVGRVISHVRHASLQKEDAAWLQKQMPGGYGPRLPSKMVIFQHATSLGDVESLIEWRAMSDSRCDPCLLRVSCGLEDVEDLKGDVRRACEALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WB78</accession>
    <name>A0A317WB78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_468829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466214.1">
        <property type="nucleotide sequence ID" value="XM_025608274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WB78"/>
    <dbReference type="STRING" id="1450535.A0A317WB78"/>
    <dbReference type="GeneID" id="37110417"/>
    <dbReference type="OrthoDB" id="540873at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000001">
        <property type="entry name" value="50S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000009">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_uL6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 10" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="83"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="9">
        <location>
            <begin position="156"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY83746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="253" mass="27854" checksum="B37CAB240102AA22" modified="2018-10-10" version="1">MSCSLTQSCFRQLARSPLRQGPLPVFLAPAFSHPLRTQPFSTTSPAQSRVGGAAISVPPEVSLKFIDLPQPKTKAKSIDFPNRAIEVKGPLGEMSLNIPSYVKVDYDEAVRKATFAVEDTEITHQRAMWGTMRALLQNHILGVSEGHICVLSFVGVGYRATIESTATTVEPEYPGQQFVSLKVGYSHPIELGIPKGVKASTPQPTRILLESVDKQVVTKFAAEIRAWRKPEPYKGKGIFVNGETIRLKDKKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBL8</accession>
    <name>A0A317WBL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_519439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466302.1">
        <property type="nucleotide sequence ID" value="XM_025610072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBL8"/>
    <dbReference type="GeneID" id="37112215"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="29"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="527" mass="57364" checksum="18564543D1C270FE" modified="2018-10-10" version="1">MAASGAKVPQVSPVETPEEYIQGPRLYAIIVLLCLSLFLTNLEIPIVSTALVSITEELQGMDKVYWITTAYMLGYVGLLIISAKFSDIFGRKSSLLVFLSIFVVFSGATGGSQTMEQLIIFRSFQGVGGAGTYSLCTVILLELIPPAKYAKYTSWISVIYAFSLLLGPLLGGAISESSSWRWIFLLNVPPAGLGIALLALALPNRFPHHNSPRQARETFSLWASLSQTIRRVDILGSTMLLVATILLVTALEEGNQQYAWRSAFTIVLLTVSGATWILFLLWERRVTLGSRAIEPVFPWRFAGRNSVCLGAVWFSTMFQLPQRFQIVNQLSPFQAAIRFIPYTVAAPLGSVLGPTIGKVFRVPLLYLVLVASLIQVASYVLLGTLPDSLSITAAQYGYQVLAGFGCGVNITLLILMTPFTIEKRDNAVGMGAIAQFRVMGGCIGIAILTAVANGYIHSHLQHALAADQWQTISHSAALIWTLSPAAQTLVRVTYSASYNLQMQILAGFAGGQVLASLLMWQKKQIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBS7</accession>
    <name>A0A317WBS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_599437</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466372.1">
        <property type="nucleotide sequence ID" value="XM_025616322.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WBS7"/>
    <dbReference type="GeneID" id="37118465"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="9"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="942"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2236"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3332"/>
            <end position="3414"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="942"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1092"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2197"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2326"/>
            <end position="2363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="2329"/>
            <end position="2338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="974"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY83904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="3773" mass="415010" checksum="20C11156220692C1" modified="2018-10-10" version="1">MNALTDYQTEPIAIVGSSCRFPGGASSPSKLWDLLQDPYDLLREIPPSRFNPKGFYHPNGEYHGSTNVMQSYLLEEDPCLFDHRFFNIHPKEAESMDPQQRLLLETVYEGIEAAGYSMQRLKASSTAVFVGQMTADYHDVLLRDVDSTPQYLATGTSRSIMANRVSYFFDWRGPSVTIDTACSSSLVALHQAVQSLRSGESSLAVAAGVNLILGPELYIFESKLHMLSPTGRSRMWDAQADGYARGEGVASVILKPLRQAIADHDRIECIIRETGVNQDGRTPGITMPNAAAQTQLIRSTYERCGLDCTKPEGRCQYFEAHGTGTLAGDPVEAKAIRDVFFPVDTAGASEQEESLYVGSVKTVIGHLEGTAGLAGILKASLALRHGVIPANMHFQRLNPAIEPYYQHLVVPTENQAWPAVPGGGPRRASVNSFGFGGTNAHAILESWEEPDPQLRATPTACGPLTVSAHSERALEVAVSSLAQTLQRQTLEDFSDLLWTLQTRRTEFPYKASFSGSSPDQLVQRLLDTGPGAIRAISVTDQRPVRILGIFTGQGAQWPAMGASLYARSRQFQECIQALDASLACLPDSPDWTLASQLQPTADPSRVHEAAISQPLCTALQIGLVDLLQSSGITFGAVLGHSSGEIAAAYAAGRLTADDAIRIAYYRGVHAHLACGPDGQAGRMMAVGMNLSDAQSFCQNEPLQGRISVAASNSRSSVTLSGDADAIDVAKHLLDDEKQFARVLKVNTAYHSHHMERCATPYLESLRRCNIQVKPGREECHWFSSVHGRDGRSIDDSDNLWGPYWVNNMVQTVLFSQALERAITEEHCFDLVLELGPHPALKGPATETIKTLTGVDLPYTGLLKRGDDDFLIFSDALGFIWKHFLSTRPVVDFAGFRAACVGREAPVPSVSRDLPSYAWDHQQPLWKESWKSREYRTRARPIHELLGTVRTHGDRQEMRWRHVMRLQEMDWLRGHEFQGQVLFPAAGYVSMAYEACMHLAGESSVQLVELMDLRIQRAITLEEDSSGVDVSFVIRRVARSDHSLTAEYTCYSCGVDGSVTEAEKTNFSGRAIITLGSPNPASLPPRCPPQLPLTSLKPARLYASLQDIGLRYSGLFLVDSVRRRLNVATVTMPRQQASPWRVHPATLDAAFHGLFAAFCAPGDSRLWTYYLPTSIERVVIGTPCERVSRHESSGLLVADCHLRSASAKIICGDVDIFCEADDHPEIQVQAITCSSFANVSPQDDRLLFSHTVWQPDISTAVLSVGHTEASPREHALVDLCERASYFYLRQLRQTIAPEEIPAMEWQFRCLMDWTRDHLLPMVESGRHSRVRPEWASDTRADIMAWTRTHPGQIDLEIIVAVGEALPAIVRGKVPILQVMMENDMLNRLYKFGLGFDLANERLRTMVSQISHRYPRLHALEIGAGTGGATVNVLQGLSSQFLSYTYTDISPGFFEKAQSMFHEHRGKMRFKTLDIERDPEPQGFPPHSFDVVIASNVLHATKSLADTMRHCRQLLKPGGYLLLLEITSNTLRPQFVMSGLPGWWLGRADGRPCHPTITEAQWNVLLEESGFSGIDTVCRDFDDPDKYMCSVMSTQAVDHRISALRLPLAYPDTIPRIGHLLVVGGQGTLELTRIVQRLRGILRPFAEHITAVAELNTVSASNVPPDSAVLCLAELDQPTFRDMTEARFQGMQTLFVQAKYLLVGTLVASNRAVLTLSGSNRSRLRVPKADVFPLGGPSPDDGMLQYLMRQLLAEVILEGESSTDGTIWVHGADDYLAPVLEATARTRGIPVFMSTLSPDVAQQTYIHPYSTERDIGRIKPTRIQTLVHLDSKRYPALDVHLRRVAHNDGAKVREIPVYRNNTPLAIPMDWVTLRAFASQFCQSPDLKLDVPAIGFPGPVPVPTLVQDAGEWAGLQVIDWTGPSTLPVPVQPLDARGLFADNKTYFLVGLTGELGLSLCHWMAQHGARYLAIASRNPQVDSMEISSLERAGVQVRVFSLDITDKASLRGVYEDIRATMPPIAGVANAAMVLRDRSFDNMTWTDFEVVLRPKVQGSQNLDELFSDTPLDFFVLFSSLACVIGNRGQANYGAANMFMATLAAQRRNRGLAASILDIGMLLGVGYVARTGEQYETQLKRYRYMSLSEPDFHHMFAEAVRAGHPDSDHPPGLITGLERTNLSREEATAPWHRNPRFAHYTYDDAEESRNGQGGPAGESRAQSSSAQSLRTQLALDVDHDQALGILEAGFSRKLQLILQVSDDSIDRVRPLMDLGIDSLVAVEIRSWFLKELAVDIPVLRVLGGASLSDLCKDVLAKLPDWNQAQAALSPAHALSAGSGTASNSDAIETPAETDSETSRDDEPGASPYERTGELTHAQARLYFPSVFLQDKSTYNVVFAGTLHGALEIDRLKAALHLVSHTHETLRTSFYIAPGKGTATQRVNLKSGIVLKQKHISDTSELDAELKALRGHEFDLEQGQLMKVVVLTSPDSVHRILFGYHHIALDGVSWLLFLQNLHQAYTARNLPSAPQQVIDMAVKQRNERVPARLGSELRYWADRYAGCLLEPVPLFPGARVSSRQILTAYDTETFDIRLDHQLAQVVRTRSSQLQMTSFHFYLAVLAVLVTQTLAVDDFSIGIMDANRVDPLDLQTLGFVLNLLPIRFQPEPHQPFTTLVRQTRDQVLGALANSRVPFDLLLEHLQVPRSAQHSPLFQVALNYRMGDSYHTPLGEGYIEWTRALGSGNPYDLTVDVTETPEDVTLVSFTTHRYLYGPRETRQLMQSYQALLEQLVADPSIPISQPSVTIDPPRAVHQGPPLAVAWPETLAHRIEDIWTTHAESTAIIDGSGGVLTYKQMARRVMQICHAFEELAIPHNSYVAMLMHPGPDVVCTLLAIMRLGHIYVPLDLRNPPERLRAIVSDCQPAVIIVDAAAEQARHLASSNIPVVDVTQFQTAGLGDTSIPNRAVGSQPAFALYTSGSTGQPKGALLTHAGFVNQIAAITSLYDVHREVVLQQSSLGFDMSLEQMFIALANGGTVVTVPQEARGDPAQLAKLMLTHSVTYTEFVPSEYLALLNYAAATLRRCVSWRLAFSGGEKISPQLRRAFRRLELPDLQLINVYGPTEITLSCSRGLVSYSTDGEDETSVGQILPKYTVSILDASLQPVPPGSPGEICIGGIGVAVGYLNKPGETARRFVPDPLDSLMTVYRTGDQGRMAEDGTLHFLGRLDGDSQIKIRGIRIELEDIAQTILAQASTTLLDAAVSVQGTAQALVAFVVFVPDFAPSDRTAYLEELRQRLPLPSYMRPACLVPVDDLPRNPNGKRDRRAIDQLPIPIGWSPTPDSGLTILDETEQQVKRAWEEVLPPSSTAHASLTIGLDTDFFQAGGNSLLLLRLQAVLATTFGTSLGLPELFQASTLRGMAQRLASSSTVTSTSLIDWDRELNSLCDGLPSTVSAYQPTSRDDQLIVILTGATGFLGRHLLQQLVDHPRVHRVHCIAVRKHDTRQSLSVRSPKIIIHPGDLQDRDLGLAATTQRTLANTAHLIIHNGADVSFLKTYTTLRPANVLSVRSLVELALPRTIPIHFISTASIAHFVPHNDLDTPLAETSVSEYPPPADSPDGYAASKWVSESFLERVCQDRGLPVCIHRPTSLVGVGAPATDLMANLVHYSGLLKAVPALDGETVGGALDLVPVGDVAGEIVQMAVELELGSEAVSTVRFVHHCSEVKIPPFRLREYLEEVHGGVVFETRPLEVWIELARAQGLLPLVADYLDSMLGRGQRVMLPVVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WC80</accession>
    <name>A0A317WC80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_601809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465808.1">
        <property type="nucleotide sequence ID" value="XM_025616399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WC80"/>
    <dbReference type="STRING" id="1450535.A0A317WC80"/>
    <dbReference type="GeneID" id="37118542"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="542" mass="63622" checksum="C668C37D271A3E56" modified="2018-10-10" version="1">MDLKSEYTSICSLPNELLDLITSHLPNRDIKSLRLSCRGLSNVLPRLKRVFLSASPRNIEIFRNIADHEIHRHGVEEIIWDDALLRMGYLSEEERDNEDLGWEFEFDRDDARNPDLCPLWFAKACRENLEMLHDRKGLDVDRPDHIARALQVVASLKPLQVHWTKYRRLFDEQRRVFTTNADMDALRYGLEQFPSLKRITITPAAHGWLFNPLYETPMIRSFSEGFNYPIPRGWPRRRDWRDRNRASMGKEKQWRGCQAVMNLLAQVKEHHVTELVITDHELERGLDCNMFKVPWEEYGDLVSILKRPGFSRLDLALAAAKMDEADIVVQSMSDWPSFHNGNLRYALAQATDLEHIHLSACYIDMKRGQKNFRSMRRGMSLNAIFPVQQWPKLRHFGISNFVVTTDDVISFLKKLPETIRSVELKFLYFLDEGGSWPNLLRRIRDEVGWRARAVTTRPKLVLALEGKTSEWPARSIWIDEEVNEFLYKDGVDPFRRLMTIPKNGVGVERDLFEPEYERPYTTDVKTLERLGIVKEPKEVWFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WC84</accession>
    <name>A0A317WC84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_599265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466307.1">
        <property type="nucleotide sequence ID" value="XM_025616307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WC84"/>
    <dbReference type="STRING" id="1450535.A0A317WC84"/>
    <dbReference type="GeneID" id="37118450"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="125"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY83839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="412" mass="46825" checksum="A75DB2F9B6663639" modified="2018-10-10" version="1">MRNDITAYHKPKLARRPIFLSSYATSDLQLVENLCQSGYSITRQASVGQIASMHGVLFFVVKELIVMNAQLCQSFDLFIHLAHCEQIFIAAIETYDVLVVPSFENILALTMGMLKAQGEAKPSLFWTLVSAAATQCQSLGYHRETTYENIVSRKADNIRRLFWTVYIFDKYMSLLLGHVSNFESLKIDARHPAVPTDPALRPWDETFLMGIKMAELQDRIFTCLYSPATSIKVPCERARFISDLASAMEQWQFELKQINSEGVDNPQVLNMSRGNWDISFYSTLTLLFHASSTTETGIQISSQCFNAARNSLLAHLDCFPQYQKSKLLSDGEYFNWILLFSSFTPFLIIFLHAISTKDTASVTLLTQVLATFENFRQAYQSSERLYEICATFTQIADKLVHSQRSSIGIYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD24</accession>
    <name>A0A317WD24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nonribosomal siderophore peptide synthase Sid2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_625396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466293.1">
        <property type="nucleotide sequence ID" value="XM_025617276.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WD24"/>
    <dbReference type="GeneID" id="37119419"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904091">
        <property type="term" value="F:non-ribosomal peptide synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000034">
        <property type="entry name" value="Nonribosomal peptide synthase sidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056896">
        <property type="entry name" value="SIDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF3">
        <property type="entry name" value="SIDEROPHORE SYNTHETASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24895">
        <property type="entry name" value="SIDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="744"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1532"/>
            <end position="1608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2140" mass="235345" checksum="2B1915B0B27EF10A" modified="2018-10-10" version="1">MGNTQTQNQRGQDSLDMADVRSFEAAGLAAATASGMKEELLLVSWLIVLLRTREDGQATYEWSYKGQNTVNKCVSTEMMTDLRSTVGQTAEAIARNIAPLQETATSALVLSTGAISQSSEEPKDEGTLHLETQYNDGRLEIRPVWQSETMLPYTATRHINSLIDTVQIVLSNPDASIEDCLRPTTSDLTDLWSWNHELPPSYDFGMHKEISRQARKTPGKVAIDSWDGSLTYGEIERYSTFVATTLKEMGAEPQDFIPVCFEKSRWTIVAVLAVMKAGCTFAMMDPTLPLARLQNMATQINARIMVSSSMQRELSKEIIPGGKFFVVEEDAFTDVPQLEDLPTLPTVPASTIMYLIFTSGSTGTPKGVKVSHGSYTSSAFPRAKAVGYNEESRVLDFASYAFDVSIDSMLLTLGNNGCLCIPSDEDRLNDINGVIRNMRVNYAGITPSVARILESDVISSLSALGLGGEAASARDVNLWGQDTRIIIGYGPCECTIGCTVNSSAATGRDYISIGPGNGAVIWIVNPNDHEELMPVGAVGELLVEGPIVGQGYLNDPEKTAAAFIEDPKWLVAGHKDYAGRRGRLYKTGDLGKYDPDGSAGILFAGRKDTQVKLRGQRVELGEIESQLKARLPSEATVIAEVIVPQGSGNQATLVAFISSQATKGVDTTELSSVELPEELSKTLSEADAEVKKVLPRYMVPTAYIPVSHIPVLISGKTDRRRLRQFGTSVDLRELDQGAASTAGRELTDLEQRLRQAWSQTLKLEAEKIRPDDNFFALGGDSLAAMRLASVCRAQGLDLSVANTFGHPTLSAMASVVLICDVETQTETPAFSLISQAAESACQEAAQVYGFDQAAIEDIYPCTPTQESLFTFSLKSVKAYVAQRLACIPADVDLDAWKHAWEEVVAAIPILRTRVAQLQEPGLQQVVLKDSISWKHSTDLAQYLEEDRNEKMNLGERLARYAIIDHPADGKRYMVWTVHHVLYDGWSEPIILKKVSEVLQNQKPEVQAQMRDFVKYVRDTDEAAMEEFWRRELKGAVGPQFPRLPSRDYLPIPDGMIERQIPLETSAGSPFTMATLIRAAWALVASQYTGNDDVVFGETLTGRDISLAGVESIVGPLIATVPIRIHINRASTVESYLQTVQQGILSRTPYQHMGMQNIRKVSHDAQHACEAPTGLVVQPEPEYVGSELGFELGDVVREALHFNPYPLMLGCGIRKGGFRICASFDSALVEVSQMERILAQIEAACTQLSKNLSRSIDEISCLPAAELNQIWKWNQTPPLSLDVTSKRLRAEESIKEGSAYPQAVVPWVCDARNPSLLSPIGCVGELWLEGAILTGETVQSPAWLVAGSSEHAGRAGRVQATGDLVQLREDNSLIFVGRKENVMSVQGHAVNIAEVEAQFTRNLPSTVRAAAAVSQPSDAEPELVVFIEEPPSNQDSLELMPTEHEVRCNIDSQTFEATIRATIAVDLAVALKKLDKFIHDSLPSYMAPFAYIVVDRIPNHNALNQLASSIHRDLLVQLRDASKQALAKASAQTNLTPSEAILRSAWAAILKLNPEQIDVDDNFFRLGGDSVLAMKLVSSLRAQGHGLTVADIFQRMRLGDAAKVLRVNVISKEEKAQPYRAFSTLGQIDNIEAFLSEKIRPKLANPQWSIRDVLPVTDSQALDVRATVQPPRTSIQYTMLYMDKDIDRVRLLRACHELVQAHDILRTVFIPQESSFSQVVIDKLEAPVAMHQAITSNLEEEVASICKTHTESAFQLGSPFTQFLHVEDPTTSQSCLIIGLSHAQYDGVSLPLLLRDLEILYIGTSAIPTPNPFSAYISHTLSPAPQTKALTYWRTLLQDSTLTTFAGSAIQPGDKSIFHTKPISTPFPFNLEEITTATLLTSAWALLLARRLHTDDITFGAVTSGRTLSSLPDVDSIMGPCYQLTPTRVRFQPTWHAMDLLRYVQNQSAESAEYDFLGFDKIAAACGWEGYFDSVVHHQDWHDFDTMPFAGGECKVDILNPDGDAAYPMKVVSFVKEGVMHVGVVGSERDVSFVDETLDQLAKVVEALSSFPGLVMQTPEINFFHSVDARFGKSRCIILPLDMRSTVKLDLVIHTCQTRHVFVAVLLYIELRRRAETDTCYPPSNSGQKAILFPVIDFEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDI3</accession>
    <name>A0A317WDI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear pore assembly and biogenesis-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_495287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465903.1">
        <property type="nucleotide sequence ID" value="XM_025609256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDI3"/>
    <dbReference type="GeneID" id="37111399"/>
    <dbReference type="OrthoDB" id="3559694at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="18338" checksum="83998179F44DA770" modified="2018-10-10" version="1" fragment="single">MDFLPESLLSLVQQHPTLQTLTSTPITSHLATLHSTYFTPYISNLRTTYLDPYLIHPLATLLTSSMPDLVSVIILALVLLISLKILDYARRLVMFWVNLAMRLLWWALVLAVMWYVYSVGIEKTGRDVGWFVGVAGGFVDGFRDGVEGGRAVTGTAMAGGYVTGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WIF6</accession>
    <name>A0A317WIF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_535963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466842.1">
        <property type="nucleotide sequence ID" value="XM_025611907.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WIF6"/>
    <dbReference type="GeneID" id="37114050"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="9">
        <location>
            <begin position="134"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="8">
        <location>
            <begin position="872"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="7">
        <location>
            <begin position="1242"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1141"/>
            <end position="1220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1562"/>
            <end position="2415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1297"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1578"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1600"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1637"/>
            <end position="1653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1673"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1730"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1745"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1793"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1851"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1893"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1915"/>
            <end position="1930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="2015"/>
            <end position="2025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2028"/>
            <end position="2041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2073"/>
            <end position="2087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2125"/>
            <end position="2136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2144"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2222"/>
            <end position="2306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="2330"/>
            <end position="2339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2343"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="2394"/>
            <end position="2403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY85825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2415" mass="268570" checksum="AFDCEFAEFB14468F" modified="2018-10-10" version="1">MAQHNYGPQSRDYSDTRGRLRRAPSRGGRNNMGRRPSTEGQNAPNGRRDNAMSPPSTTPAKDVQDPSQANGVPPTANQQKPPSSPLPSPASSLPQSHIQPSPAPTPTPAPAPPAPMSAPQPPTGPPQPYDYEHVTQNATEEWAATGKKAIVENGIQARDAQDASALASIYQELIRSALHGRLSPEEAGVTVKEIIGEDVAADDVDMDTEGSSSGLLDTRSLFLDTLSIMTDSDTSNTALRPLVFSTGINPALMRLQLDTQLLQALGLVRETFTRMGIRKQTNLLYRQSNYNLLREESEGYSKLLTELFTTSNNEPPSSEVVEDTFERVKAMIGAFDMDVGRVLDVTLDVFAAVLVKQYRFFVKLLRASSWWPKEDVFRTVDVGNRDSGLPNWALPGSTGWVTTDEERIEAMKANEQRDHEFWNRVRDIGTRAFFEIGRRPVSKEELQRILPESNSLSEEEKEMRKWIEETGTLPPKGSRVAAQLLGFKLRFYSSRARAKSDVLPDNLIYLAALLIKVGFISLRDLYPHLWRPDDSMDALKEEKMKEKAERERAARPGGGVNALMMAGALSDDTLPIPRMRESETRSATPGKDQETDKSTGPKTEEDELPEPSDQKVMLLKSLLAIGALPESLFILSKFPWLMEAYPELPEFIHRILHHCLNKVYASLRPLPSIDELKEQKQILNHDQAGVPKGQIRLTQAPPRRVLRWAQLDKEDTNDGTDYRFYWDDWADNIPICQTVDDVFALCSSFLNLSGHKIGQDPSLLAKLARIGKDSMSRDHSPENRARWQDLCKRLLVPSISLTKANPGVVNEIFDLISFFSREVRYNMYAEWNSGQTSRLPDIKSAFEQAKAETKDILKRLSKTNIRPMARALAKIAYANPGVVITVAINQIESYENLIEVVVECARYFTYLGYDILTWVMISSLGQKGRSRVQEGGLLTSRWLNALATFAGRTFKRYSVMDPTPVLQYVVEQLRQNNSTDLIILEQMISSMAGIITDNNFNEAQIQAMAGGELLQSQTILQLLDKRHESKTTSRRLIKSLTVSKLAGQLLIAIAQERWTCIYKETEGASELKLLGNIFDEIHRILVQYLDLLRSNLSVEDFDSFVPDLATLIREFGIQPEVAFWIRRPSVAKKIADMERTIQDEDSSTTTVTVAPTRDSEDASPSKPEADKMEMSEDGEAVVAENQQSENAMDIDQGKPENADDPSSEKATTGPAPTEGLALNPVMQDLQDQVKDVLGSETWGVVGAHFYVTFWQLSLYDVHIPQKAYEDEIDRQKRKVIAISNDRSDISMAGTQRKEREKRQLTQLQDRILEENKAHLKAYGQTRAKLQKEKDRWFAGMRGNYDSLNVALLEQCFLPRLLFSPIDAFYCFKMLKFLHTTGAPNFRTVGLLDQLFKEHRLVALIFQCTSREADNFGRFLKEVIRDLGRWHADKAVYEKEAYGTKRDLPGFAKNVDPEGKPTTFLEYEDFRRLLYKWHRLLVLALKSCLDGGEYMHIRNAISVLKAVVQHYPAVNWMGYKLLTSMTNLSQNDERDDVKIPAASLIGDLNRREKSWGLPQEFRFEQGTGRGNQTAAAAKSSTPRPQSSTPTPLNAGAAEFKPTSTSESQGASKSESGPTKAEVEDGEIEDARMTDVPMVDRTAPTPAVTTDAVTPQRDSEPQATEATPLTAREPTSSDKDVTTVRGAHLEGDLPPRPVAPASPAGSHLVSKGLDVGRPANVPKRPETERAPSGTQNPRSQGQGLHRFPRDDKLPARPDLLEDRRDRLQDYPRGGRFGGDHDYPRQFDAAMGDGRNYGRLDREYASRPPMEEAFRGPHRDGRPPRDGDWPDRSGRLRPDAREGLANVRPGPPTHPDRAGMIDDHPEGYRRGDAGRQERDDRRTLAPRALSPPRIDPQGRPERFSAEDRRSGNFSHTHPRNEDMPTGPRSERFGRPSMDGAESRDPVTGIDMNHGRLRQPEPPSDVPSGPRGRNIVGRGGRNAAGLPHPQAPPANGPMAVPERQPPTGPGRQGLRNAPDPSPTTGPPSPGAEKLDTSGIHPDRLKVLQQQPQDKAYSGSPRSQHASPSAAIVPPSGPRSGLGPPAGPSSMPRGPPSGPGFGGERGRGDKRFAGINNMLQQSGGPPDRGPGPAIRGRGANRQAAAMNAPSPQSARSQTPVAQEDGGRAGSSTQGRPDLMAGRSSGAAYSEDDSHPRNRLGSGRETAEDAGSTETRRTQRFSSGTTYPHDRDRERERERDRERRGGEEETSRSSSRREEHRERTRDYERERSRRSDVAAGANREERYESREASRRGPGAREDNRRRRDRDEGADLTPSNQEHEGRLRPPSSLGGQAPPPPPPPPAAGTEEERRWGGGRDLRDRDRDRTRDRPRDRDYHREGGSGGPHRKRHRPGDEGGHGDGSGRGGMRMGSENKRPRRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WK93</accession>
    <name>A0A317WK93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_84017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467076.1">
        <property type="nucleotide sequence ID" value="XM_025617700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WK93"/>
    <dbReference type="STRING" id="1450535.A0A317WK93"/>
    <dbReference type="GeneID" id="37119843"/>
    <dbReference type="OrthoDB" id="4064873at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009410">
        <property type="term" value="P:response to xenobiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052478">
        <property type="entry name" value="Metabolite_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31779:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY86485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="560" mass="62258" checksum="F2137AAD82B44896" modified="2018-10-10" version="1">MSSTPGRSTRSPLGSTRRRTKNACETCKVRKRKCDGHEPCTFCLRYEFECSYGAQPRKKRSSSSTTRPSVRLRERPSSPGLGTRADVNQQQMEANSGTAFPHLLGKSLNPQNPPKVYGFSWNLGLRDEPAQNFTNIASLISKEEMEDLVGHYLERIHPMYAVLNPDILQKKVASRWGDSATLDSYDPVLCGVAALGSLYSGHQGHRNEGALVQCAKEILETTCIMNKPLLHHATAWLLRTIYLRSTNCPHASWMASCSTMHIIEAAGAHQDPGMVSLVYSDTADVGVDEESQRRLFWVATVLNAWISYEYGRSRVILRGVSCKPPLPQAGDFTADLISLFQISERLDPEQTNRPSDLEDILARVERLRFTHDALILSQSNLALTIYRRLRVAASSISNDVIGRIIRLGTEGIAAAVRMAEKRCPWWHVANVPFQFLCILLAIDSRESLSHVGHAMRSFKTIGMHFSTPTVYTAIDTIDSLIKLSQRKKEREISLLKDSVQDQNAAPAEQSATSAQAYGTPWLGEIADANALGNSDWDWDAFLNAEIPLFDDAGYGGQRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WP80</accession>
    <name>A0A317WP80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DDT domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_66321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467260.1">
        <property type="nucleotide sequence ID" value="XM_025617585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WP80"/>
    <dbReference type="STRING" id="1450535.A0A317WP80"/>
    <dbReference type="GeneID" id="37119728"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50827">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="7">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="DDT" evidence="6">
        <location>
            <begin position="388"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="456"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="679"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="955"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="684"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="971"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY87052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="998" mass="115601" checksum="010D98E5BFD9B56F" modified="2018-10-10" version="1">MVLFKRKPVQYLPRPAIEDDSSEVWVIPETNEVFINYEPYLQRMDFYKQRRFICEITGHSGLTFFEALRSEMEESREVNSAFPDALKEPILRRIQFSTVSRVDNLVDEVFEEFKQDFYPGEPVLILLDDNTRLHGIIRDKVNFPDQLNPDGSLNRPAYSTYLVKVTDRPNEEALLDQEHITRDRKTFTKQMLRAFIKNNVTRESWNGAPWLVKPSIAEEYRIPTEVPKHLQYGAKVAEKKAMKKADQEGFFGFFASQQLPELKPAVKGQKVKPSQQDLARNKEAQFLEYQRSLNGNPTFVVANKPTNGVIRSTKTQETDKKTPPVPTVVVKAEPPKAPTPLPIKYPIEDLDIAPDLEKKKQRPALKFLTVDETDGPEDVDLLHDDIEIESVGRLLETWNTLNVYCEVFQLDSFTFDDFFQSMRFSSEDVDCELFVEVHCAVLKKLVNAEKDENGAIQISLPELPDEEDDESEGEGEEEEEATPEPVVTRMTTRSSLAKAEAENLRAQADRERSSSVEVKVHRAAEMFVEYGWIDRLRKRDFRNGGWEMVMIGLLHQLSARARMEKACNDILKHLAPLDAEPTQETAQAQYSTLDVNLRIQALQIICMLSLETKAVRNYLEECSNQMTEFRKEKIEYQKARKAGLEELRRLHQERKALQPEPEKSPSPAPELEALEDSKMTGVDGDSDQAMDSDDEAVPQRTLRGGLDRALERKRKQEEERERKEQLAKQPKGSKQFQRVLKKIDDQKANIKKLEDKIDVVDNDLREADCPRTRCLGKDRFCNRYWWFERNAMPYGGMPNSSTAEANYANGRLWVQGPDEMERVGFIDVPDEPRKLYQKAFQTTPAERKKAEEGHTRLTTATEWGYYDSPDAIETLLDWLDSRGHRESKLRKELLQQRDNIAKYMNYRKEYLEQTSDRAESEEIPSKRVMTRNKTYVDDNKHRCMRWRNTTALSDNGHLHVDASRPTKRARRVTDEPKEIKATNRQGKPLTRQGTRYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQ32</accession>
    <name>A0A317WQ32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine-phosphotransfer domain, HPT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_72221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467445.1">
        <property type="nucleotide sequence ID" value="XM_025617624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQ32"/>
    <dbReference type="STRING" id="1450535.A0A317WQ32"/>
    <dbReference type="GeneID" id="37119767"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.160:FF:000007">
        <property type="entry name" value="Multistep phosphorelay regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="65"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY87237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="179" mass="19755" checksum="D12540483CD3FAA3" modified="2018-10-10" version="1">MAPTTTTKTVEEPVRVAVPSADAKVDADVPKPKETKPIPSTLAEMSESIDQTTFEQILEMDDEGDNDFSKGIVYGFFDQAESTFEKMEKALKEEELNELSSLGHYLKGSSATLGLIKVKDACEKIQHYGAGKDETGSTDEPDKKTSLSRIEKTLTQVKVDYKEVEAFLRKYYGEPASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQ87</accession>
    <name>A0A317WQ87_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cysteine-rich transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_45091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CYSTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467955.1">
        <property type="nucleotide sequence ID" value="XM_025607539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQ87"/>
    <dbReference type="STRING" id="1450535.A0A317WQ87"/>
    <dbReference type="GeneID" id="37109682"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028144">
        <property type="entry name" value="CYSTM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12734">
        <property type="entry name" value="CYSTM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cysteine-rich transmembrane" evidence="5">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY88593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="111" mass="11920" checksum="77DE42BEDBB41821" modified="2018-10-10" version="1">MSYKPENPPPSYPPPTHDGGPYPGASQDYYNQGYNQGYNQGYPPQNYGPPPQQQGYYGAPPPQGQPMYYPPPQQQPQGYYAGQDRGGSSGGGMCAGIMAALACCCCLDILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQZ8</accession>
    <name>A0A317WQZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhamnogalacturonan acetylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_424793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467181.1">
        <property type="nucleotide sequence ID" value="XM_025607432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQZ8"/>
    <dbReference type="STRING" id="1450535.A0A317WQZ8"/>
    <dbReference type="GeneID" id="37109575"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY86590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="230" mass="24275" checksum="EFBEDB1A0B57734D" modified="2018-10-10" version="1" fragment="single">ATTIYLAGDSTMATGGGGSGTDGWGNYIAPYLTNTTSNPTTLSNQAVAGRSARSYTREGRFTTIASTLQPNDWVIIEFGHNDGGTLSSTSDNGRTDCSGNGTEICYSVYDGVNETILTFPAYLENAANLFLDKGANVIISSQTPDNPWETGSFVYDPTRFVAYAQLAAERTGVAYVDHGGYVAAVFEELGESVVDGYYPVDHTHTSVAGAEVVAEAFLRGVVCAGLGWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSJ9</accession>
    <name>A0A317WSJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 phenylacetate 2-hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_535121</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467910.1">
        <property type="nucleotide sequence ID" value="XM_025611705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSJ9"/>
    <dbReference type="STRING" id="1450535.A0A317WSJ9"/>
    <dbReference type="GeneID" id="37113848"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11066">
        <property type="entry name" value="CYP_PhacA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0349">Heme</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY88127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="516" mass="58331" checksum="09C4542ADE790DB7" modified="2018-10-10" version="1">MAFQTVLLAAVAVVYFIIRYLNRTDVPKIKGIPEIPGVPLFGNLLQLGERHAVVARKWAKQFGPVFQVRMGNKRVVFANSFDSVRQLWIKDQSALISRPTFHTFHSVVSTSQGFTIGTSPWDESCKRRRKAAATALNRPAVQSYMPIIDLECTASIKELFKDSQNGSVDINPKAYFQRFALNTSLTLNYGFRIEGNVDDQLLHEIVNVERGVANFRSTSNNWQDYIPLLRILPKQNREAGEFRVRRDNYLSFLLDILKERIAKGTDKPCITGNILKDPEAKLNEAEIKSICVTMVSAGLDTVPGNLVMGIAYLASEDGQRIQQKAYDEIMKVYPDGDAWEKCLVEEKVPYVSALVRETLRFWTVIPICLPRESTKDIEYNGATIPTGTTFFMNAWAADYDEDHFQLPDKFIPERYLDIGEGSGTPHYGYGAGSRMCAGSHLANRELFTAYVRLITAFTMHPSRDEADRPILDAIHCNEIATGLTTEPKPFKVGFKPRDPVSLQRWIEESDERTKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTQ8</accession>
    <name>A0A317WTQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 10">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_490446</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 10"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468386.1">
        <property type="nucleotide sequence ID" value="XM_025609122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTQ8"/>
    <dbReference type="STRING" id="1450535.A0A317WTQ8"/>
    <dbReference type="GeneID" id="37111265"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="11">
        <location>
            <begin position="338"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY89475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="421" mass="47443" checksum="A7DE500103803778" modified="2018-10-10" version="1">MASSDPSIRWKHLYRVLTKSGPFSDEDWVPGQETISALESSKVLVIGAGGLGCEILKNLALSGFKDIHVIDMDTIDISNLNRQFLFRQSDIGKPKAEVAAAFVERRVKGVKITPYVGKIQDKDEDYYMQFKIVVCGLDSIEARRWINSTLVGMVDFEDPESLKPLIDGGTEGFKGQARVILPTLSSCIECQLDMHAPRPAVPLCTIATIPRQPQHCIEWAHQIAWQEKRKDEPFDTDDMEHIGWVYNTALERAKQFNIPGVTFQMTQGVVKNIIPAIASTNAVIAAATTSEALKIATSCNPYLENYMMYAGEEGVYTYTFEAEKKPDCPVCGNLARKLTVDPNMTLEEFIETLGERPEAQLKKPSMRTEEKTLYQRFPPQLEEQTRHNLKLKLKELIENGQEIAVSDPAYTIDFRFRLAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WU73</accession>
    <name>A0A317WU73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_595153</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468204.1">
        <property type="nucleotide sequence ID" value="XM_025616216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WU73"/>
    <dbReference type="STRING" id="1450535.A0A317WU73"/>
    <dbReference type="GeneID" id="37118359"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY88842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="507" mass="56411" checksum="37EE9C422BF9D44B" modified="2018-10-10" version="1">MRLWKHDFRGRALIIAITMASCQAFLLLGFDQGVMSGIVGADNRFARDFNNPDAAMQGNITGLYDIGCVVGSIICYFIGEKMGRRTMLMTGGFIMVIGSIILSSSYTLAQLLVGRIITGLGNGMNSSTAPVYQSECSPAAYRGALLTLQGTVTILGVVIAYWMDYGTSFTDSSYEWRLPLAFQAVFAVCLIFQVVGLPETPRWLVQHDRHEEARAVVAAIEDTTIDDARVTKTILDIQFVLEEEQKDGPFRFKELFTWGEVQNLRRLLITITIELGQQFTGSNMINYYGPVMFQETMNMSRNLSLILGGAMQCTYLVGSAIPVFLMDRYGRRTLLMVCSAGLCLCFVMVAILLSLDREDCAYGATAFIFIFQIFYGVGWLPVPWFYPAELNTTRVRTRMQAIASGWNWMAVFAVVKITPIAFDNIGWRTFIIFAVLNAVFIPMVYFFYPETKGLELEDIPLLFHKGGITGGVFTSKGGRTVTPGQHALQAHVDQKVEGTVHQVEDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVU5</accession>
    <name>A0A317WVU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Altered inheritance of mitochondria protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_34959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468333.1">
        <property type="nucleotide sequence ID" value="XM_025607094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVU5"/>
    <dbReference type="STRING" id="1450535.A0A317WVU5"/>
    <dbReference type="GeneID" id="37109237"/>
    <dbReference type="OrthoDB" id="4499526at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY89422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="436" mass="49455" checksum="EBCA5A0AFC9E44D2" modified="2018-10-10" version="1">MAAATHPNFRDRSITQPLLEADEYDEYSWVLLEDHPLRSPPAECCPGIVWVIHRCCAAVSKRWSDRALSLICLFLMFLVAIQFLSLLPYGVSYIFLREQYKQQTGFVHWPVEFNNQPAACISYNPRAHSSAIQYSVAAGCTGIKADIWLQDDDLLVGPSTSSLKKESTLRSVYLEPLLDQLDARNTDEAQSDHGTMSAWTGLFEWNPMQQATLFLEIRSSTQDVWPRLFSELALLSERGYLTHRNGTLVVPGPITIVLTGRDHVNIYDTHLVDHKNLVDYLFFDERLIVDAEGSAATPASTEDQQDHFEQSSRISIPDLDIPPLGRAIQLYSASVNFSTAIGSPHRGRFSPRQIDLIKSQVRAAHQRGLLARYEGIPCYSEGMRRIIWRILVNEGADFIEVDWTGCASRGWRRFFSIGARDWSGNQSRHLLWPWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW10</accession>
    <name>A0A317WW10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_593418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468927.1">
        <property type="nucleotide sequence ID" value="XM_025616181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW10"/>
    <dbReference type="GeneID" id="37118324"/>
    <dbReference type="OrthoDB" id="10608711at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY90549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="610" mass="66981" checksum="2E6E379ED19B85E7" modified="2018-10-10" version="1">MTYSRFVNYKGNLFGIDDFHLNKSFRLEVDLDWSKTVLPYLNIKDQDTRGRQKYVILRGSIFISCALICIASQFCLRQRDMVEDVPNQDHWVILISLMSVTCQGWPISLRIQRNIIKDQSLADVLHTKHPTPKTSDRGIRCIPERATIEPGTNPESEPKLGIDHVTITPKATHLRAHAVARVYTRRKAQDAAREKERDNLVKDLTSIDVHGRKVASSYSEFVAMLESNAKSNVIPKQIALQMLTTLSDSIISICKATHNVSTFIHFASGTVGGDSDSYASETKDPATYSRVTPGETKSVSSQSRAPSTVTDAFKAMSPAEIRRTRQRAKTPAPPETPPLKPTGAAATSEMPAPATPTPVKAGSLRAQRLASQSKTPAASIAAALVSTSLKLSDVEASAFTIIAEYMSTEREDAESSSFAEQLMASIKYKKAKGSATTDAIKAVRSNMGKDKAHNAERDTGNPCKISSEEPVVAVPNERVEWDTDTAHSLHVAFAPVSDNTSDFTRNNLRNKIPRRYFDVKMTFAWQGVESVFLRADDGIIPYVFPPAKAKKTAGQATSYGKSYVYAAAVKVSGPVPRPKLSAIGTYLSAFEKDESATNSQPGTFIERYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW27</accession>
    <name>A0A317WW27_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_584775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468433.1">
        <property type="nucleotide sequence ID" value="XM_025615653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW27"/>
    <dbReference type="STRING" id="1450535.A0A317WW27"/>
    <dbReference type="GeneID" id="37117796"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="124"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="235" mass="26079" checksum="E207D79DE1888BC0" modified="2018-10-10" version="1">MDLPESVPPGMLLREVADKLDKDYNHLRIRLSGNGASLEEVLTATLDCVHTVPEHISLPTTKPTFGAKLCASLDAIISLLEAIHSTLCAVLLLGNLIKSVTNPSYEPTSSELRHLLEEIHSEDSKEIIIFEDAIGRKHSLQFNCCRTWIGMEKFIRQAFLQSDVIETHVAKGYYDLMGSNGDIILPQDWESVVEPGWVITMYLRPISEVSELSEAVPSKQSPKVKPLTLESSPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY48</accession>
    <name>A0A317WY48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRAP deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_21217</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468640.1">
        <property type="nucleotide sequence ID" value="XM_025606162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY48"/>
    <dbReference type="STRING" id="1450535.A0A317WY48"/>
    <dbReference type="GeneID" id="37108305"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02557">
        <property type="entry name" value="PseudoU_synth_ScRIB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="4">
        <location>
            <begin position="133"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY90262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="521" mass="57833" checksum="CE1D4493AC784205" modified="2018-10-10" version="1">MSVVPVDTTLQVPPPDPVQEPPKVAVTPCDPWPANYYFEGGLRRVKPYHYTYNTYCKERWRGRELVDIFLSEFRDRPAEYYRKALADGLVAVNGKPAGPHTVVKNGEIISHTLHRHEPPVTGKDIGIIHEDDDLIVIDKPAGVPVHSAGRYHYNSVLEIMRSQRFREWVPRPCNRLDRLTSGVMFLGNTPKAAENMTKKLKARTLQKEYVARVKGKFPDGVIVCDQPIMSVSPKVGLNRVRATGKEAKTKFRRLAYIPPQAPEPQTVDADGRPATPPPIYSNESEGYSIVHCLPLTGRTHQIRVHLQFLGHPISNDPIYSNRKVFGPDLGKNETTDERDSELIDRLCNIGKTEVPDTVSYRTHLTAAPLVPPGTDSSVVEQIMSREHEAAVERYHKRKGEMLSGDRCSVCDTELYTDPRPEDLGIFLHAAAYSDKEDGWKYTSKMPSWGLPPDGVEGPREMPDWVFGPEEDEIVIGYGVVPDLGDGSEPNIPALVQGVGLVDISSGRKADAEAAEAAAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY51</accession>
    <name>A0A317WY51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO94DRAFT_533467</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Associates with the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469062.1">
        <property type="nucleotide sequence ID" value="XM_025611340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY51"/>
    <dbReference type="STRING" id="1450535.A0A317WY51"/>
    <dbReference type="GeneID" id="37113483"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="21">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="19">
        <location>
            <begin position="115"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="20">
        <location>
            <begin position="316"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PWY91334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="490" mass="53765" checksum="FB751881BA56B26E" modified="2018-10-10" version="1">MASEQPAGGSLADRISKPEDSLPTDAPEQTPEQTPEQVVGNDQIDGAPAELGGSDLQEPEYTVEVKLSDLQADPNNPLFSVKNFEDLGLDPRILQGLSAMNFRKPSKIQERALPLLLGNPPKNLVGQSQSGTGKTAAFVLNVLSRLDLSSEQAQKTPQALILAPTRELARQIVGVIQVMGQFLDGLAIGTAVPADSNARHAKLECSVVVGTPGTVMDLIKKRIMIAAKLRVLVLDEADNMLDQQGLGDQCIRVKSLLPKDIQVVLFSATFPTHVHEYASKFAPQANELTLQHEELTVEGIKQLYLDCSDGEDKYQTLVQLYGLLTVGSSIIFVRTRKSAEEIERRMVAEGHTVASLSGGVEGSQRDSVIDKFRAGQAKVLITTNVLARGIDVSTVSMVINYDIPEIHQPGAPQRQADYQTYLHRIGRTGRFGRVGVSISFVSNREEWEMLNQIQKYFNTSIQRIDTKDWDEVEDVIKKTIKSSRAQIGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYU3</accession>
    <name>A0A317WYU3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein Ral2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_555387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469292.1">
        <property type="nucleotide sequence ID" value="XM_025613791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYU3"/>
    <dbReference type="STRING" id="1450535.A0A317WYU3"/>
    <dbReference type="GeneID" id="37115934"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="827" mass="88993" checksum="287D85563C890BE9" modified="2018-10-10" version="1">MMSRSQSSLDPSATGAQPGLQPPSSNSGPINLSGLVCNVRRTTGREPHPLVGATTTILGDKLYVFGGRVLSKSRPQLTSDIYELDLIRPTGDVPRPRYFHSLVCYGGMSPALNVAKESATNGSGGQEAQPEVVVMSDIHIFDVPSRTWTRVPASDSPQGRYAHCATILPSSAHFTSATAPLSAIHHNPASSNPHQGSIGVDIDGFGGAEMVVVGGQDSSNHYIEQISVFNLRSLKWTSTSHLGRSCGAYRSVVAPLVGMNVSDIGSAADNQEEQEPVEESQVEGCPMLVYSNYNFLDVKLELQVRLPDGRLIEKPMQSQASPPGLRFPNGGVINGHFVVSGTYLTSSKQEYALWALDLRTLTWGRIDAGGSVFGHGSWNRGILWSRRNTFVILGHRKRSLVEDYNHRRINFSHVCMVELEAFGLYNNACRTTPTSGYISYSAPSVPASMQPRLTKLTSGGRPFSSASDELGSLAQSLPEMADMELQAVGGERIPVNSRILTRRWGPYFIQLLRESCDGGIGETVTLRPAVAMYPSRNSSITITPSIGQNSNYSTSSTLVSNHSATSKSLLANLEIPSAHSLSPTSRPRVLYLPHTFLTLQVLVYYFYTSSLPPAGSPLCTPQILCSLLQLARPYQVDGTGFTSGPGGTLEALNGAHASHESSSGTGTTTSQSHLTSDSSDTEHGTSAVSVASSASGVMGSRGIPLRINTNIFSRRQRSTAGLDRERERDRDREDAMSNASTSTSASTNTSFDHSDTEMGGDPTRPSHHRRNTDAELRPEREIWTGDLSSVIGLQKRGLRGLMEGRRLRERNTKPANGADHGALAPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ25</accession>
    <name>A0A317WZ25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_513932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469357.1">
        <property type="nucleotide sequence ID" value="XM_025609863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ25"/>
    <dbReference type="GeneID" id="37112006"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="261"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY91629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="651" mass="72154" checksum="198CA00F472178C7" modified="2018-10-10" version="1">MSKGGGGSVFSNIGSSTEAQTGFNQGLTSVADETHIHLHTPSNHLTAHGNLQSKSRENKNLLTAMGITPNRSISPSESQNEFFGDSSVASLLRQINVSVTSKPASAATPSSPRMAEKSDSAVNPYDLPSRQIADYLLECYFDKFHTLYPFIHRPSFLRAYHNLWEPKAVTDVESLTRIGFGLSDPGVQSSTFLCALNIILALGCQFSQLNHATREATSEEFFQRSQKYLSIVTMDKGDLALVQTLLLTATYLQGGESPSKCWNIIGLACRVAQGVGMHSLKADRNRSSAEIQMRRRVWHGCVMFDLASSMMLGRPPMTYSSPVPLPEALDDEYLHSPQLPRNHGVSRAEFYIQTLQLHTILRKILLEVYEPLENSSPPYPLDYLKTDNYHAQTLMKLDAELLAFKSQIPTALQWNKQSASDQFRRESSLLRARFLHLRTLLLRPTLVNFCREGRMPNTLDHPSTGEQHTALESKISLDFSLSCSTYCVETAIELSHLMNEISRTELASVWWYSIFYTFTAGVVLILAQTSSALEPNFTKQRLHDAWQSCTDCLETMGSYSSTAHVYADCLRKTLSQSLHEGSGNVSSTQDVTSRPGTADLGPPDCFVADPVVDHLPFGTESSNGTWGGNDLAGSLLEMMWDDSWLTAPTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X003</accession>
    <name>A0A317X003_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plasma membrane antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_384415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469671.1">
        <property type="nucleotide sequence ID" value="XM_025607282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X003"/>
    <dbReference type="STRING" id="1450535.A0A317X003"/>
    <dbReference type="GeneID" id="37109425"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF5">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="7">
        <location>
            <begin position="28"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY91943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="564" mass="62520" checksum="222EE0154393B004" modified="2018-10-10" version="1">MLHPFLDVSNFNLVLSVTGLYILLFGFISLKIKQRWYLGEALPAFIIGISFGPIGAKFLNVSQWGGNDDDETSEIAYGLTRLVIGIQLVKVGYELPKKYLRQRLVEMIICLLPLMTISWLATTACVKLMIPRISFLAALIISACVTCTDPVLSQAIAKGPFADNYVRRPLREFISAEAGGNDGFGFPLLLLGVSLLRYAEAPANTLSLEEFDLERGIPDVLGTTGVGRFGGGAGIALKHWAIEGVLYMILVGAAYGAVVGFTCQKLLNKASERRWIDNESFTLAPVAIGLLIVGTCGCFGSDETLACFIAGCVLNWNGLYHEEMQARHDSFNSTIETLLNFSAFMFLGATMPWKSFQRPYDTGITLWRLFGLGFMILAFRRIPSILLGYRFMPKVCSNWKEALFLGHFGPIGAGAVSYVEYTRRLFPPPGQSDREINNMTAAMVPVVYWLVLFSIVAHGLSVPALNLLYQVFNVPRIYDHPVSVVLLSENEPLPNNSTIDPQRHSMIINNRFSRPSESDGEEESKEDTETMLRSREDSPAGRSMERLSIQSGRSDRTVNMRNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0A8</accession>
    <name>A0A317X0A8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_555414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469329.1">
        <property type="nucleotide sequence ID" value="XM_025613793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0A8"/>
    <dbReference type="STRING" id="1450535.A0A317X0A8"/>
    <dbReference type="GeneID" id="37115936"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="281" mass="32046" checksum="F530EE5BC0FA5A8F" modified="2018-10-10" version="1">MSLVPGFLLRGARSNYRILRTMTGDNTHISTIFKAAVVPHENARQLPDAPNWAIIKVADAKSMKCMTREQQVYHFPGVASAECFRKMYDVIDDNVRYQPDQDTDALIMSFLRATLTSCVVLESHQHVNTEFKPSNILISNLNTDSIITKVDDLGLVVPSNSFRECQPFAMRAPEVYLGAPCTEPSQVWAIAAMILEWVKPDWDLPRPEDVDDPIFKEQVAPDLGTISPFDKETRKVEMPQELRDLLRYMMVLHPEKRPSAMHVLASKEFRDFERFVGSWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0D4</accession>
    <name>A0A317X0D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_533920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468816.1">
        <property type="nucleotide sequence ID" value="XM_025611425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0D4"/>
    <dbReference type="STRING" id="1450535.A0A317X0D4"/>
    <dbReference type="GeneID" id="37113568"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY90438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="176" mass="19379" checksum="5E8C43837ED1E8CA" modified="2018-10-10" version="1">MSSSRIGLRFFQNSRAAFRNAYGPFRRPGGQGFRFQSSDAAAAEQQSTFQRLWNSPVGVKTVHFWAPVMKWALVIAGISDLSRPAEKLSLTQNGALMATGVIWTRWCMIITPKNYLLAAVNFFLGCVGVVQVGRIFNYRRSLDGSSTEAVKDMEHEVADQAKAVATQAEAAIKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0H0</accession>
    <name>A0A317X0H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_375991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469389.1">
        <property type="nucleotide sequence ID" value="XM_025607231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0H0"/>
    <dbReference type="GeneID" id="37109374"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19364" checksum="82B4DF25D18D1A7F" modified="2018-10-10" version="1">MQEIDWRANLKNVHCRERWTMLIHIPTLRGFLDTTHGNYRCCREAGDIDRWWPLGTQLDCPWHWGWRSTRGPVRLLAEDITMTHRWTWKFPIGRSAPLSRGWDAAPGESPHESLRLDASRRVEIRSTGHNPSSLCPSAVCLCTAIGHIDSVDGCSLWPCRMRPSPSGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0R9</accession>
    <name>A0A317X0R9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_29979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468936.1">
        <property type="nucleotide sequence ID" value="XM_025606728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0R9"/>
    <dbReference type="STRING" id="1450535.A0A317X0R9"/>
    <dbReference type="GeneID" id="37108871"/>
    <dbReference type="OrthoDB" id="4150019at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48192">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48192:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY90558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="367" mass="39558" checksum="86866C136DD5EAB7" modified="2018-10-10" version="1">MPAVVEDIIPTNNSEGTVMEPSTADKKRNKLGYHRTSVACVHCRRRKIRCLVANDDPQGRCENCIRLRKECQFFPVDQQPPIEKKSRPSSRLETASTDPSTASSSPPNVTGVEQTEPFYPYQPMPLGSNPDVGAFNAATFSGNPMAPFPPDRNVGAEFVPPPSIDPSVPWDEYTTISDPQLLATMSAGKAMMNMPTNVWGPTPNPMAPMPTTAPLPGTPTVPSQSQGLTQAPTYAMQPDGTVWQVPTQRSMTFSAQPAEMAMAYANQGPFMQPSPAELKRRMTSPAQSFPGTPINPQSPPAADLQAVSVSYPGQPAAMGFNNWQDMNSMSPMGMVQYPMYTNDPAQQAGFGSPPPMGHPGHGHSPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X398</accession>
    <name>A0A317X398_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_532868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469860.1">
        <property type="nucleotide sequence ID" value="XM_025611211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X398"/>
    <dbReference type="STRING" id="1450535.A0A317X398"/>
    <dbReference type="GeneID" id="37113354"/>
    <dbReference type="OrthoDB" id="5952526at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="367" mass="41239" checksum="CBB9A32B61990220" modified="2018-10-10" version="1">MATSLSNGCGHCGQTKNLRRCSGCQLMFYCSKDHQKAQHSAHKTACHAVSRARVFHNRAAAPIIHTCGGPVTLTSIPQVVRDNREVFQGWMHDYLFSKYLLTEVMDKINTRHAVQERLDLLLSLVHVFRADEVGTRWKIPALLIRLKRDQESYDFMKWFCLAKKPDPIDEMNPALPFLDLKNADALENVTPFITDWEVTPLVERVHTMLALTLLKVRLVLDLRMVETVGTAIGGAILPEILIHIQAHVVESSVISKDRALLARWDHAATITELEKQIRVLMETVQRFNQHLWSTLADGQSPMAIVYTSGSPEEAASIVTQCHAAWSESPGAIAFIKERLADVEGVKGEREDPTIRIVQVDQAFSSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3P3</accession>
    <name>A0A317X3P3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-s/LopB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_532980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470015.1">
        <property type="nucleotide sequence ID" value="XM_025611241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3P3"/>
    <dbReference type="STRING" id="1450535.A0A317X3P3"/>
    <dbReference type="GeneID" id="37113384"/>
    <dbReference type="OrthoDB" id="5418235at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="260"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="777"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1228"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1268" mass="140941" checksum="131A884A229D1526" modified="2018-10-10" version="1">MSVLRHHGSAYLQRRLTKMYTDTKTSCESVTTASIAVDDPELVTLHRSFKTQRDRLLAWGLDWSDASAAQPNDIDESITQAGYSDVVASVMSSIQVLLNEAERIQHGGSDLPPKGAGADSPKGGLSNLPVKSHWTSEEISRSKTLLSDLESCIDTLYDLSRSRRNMSASMTAGGQSATKGRSQPGATTDYSILDSKAYHAASFDSPLAPSPTRNAAAFSQARSEKMPFGKISLTVDNYAIDRSALQLSGSSHDNNPPPYEQVAASINSRAIGRMRTSASPFLHGSKDSVATILVDYTPMVLEASGAATTPEKKRLDHVQQTLEQLVQNARVSHLGLLKLLGYYIDMPNSRYAFVYQMPVDYFPFLRNPSDLLNGLKPKPLVSLFQAGDDYHIPNLETRFRLAYDLLMAVLQLRSQNLVHGNINSSNVLIFPGLTNSNSDEVGLTENLRRPYLTSFAQFSGNGPSPEPLSSSMYRHPDDKRSMDDDAAWAYDLYSLGLVLLEIGLWNPISRIWKMKYNNSMFKQRIENVYLQKLGPKCGSAYLHVVQLCLDAPNFHLSTQPFDDLNLRVPQAFHYPVLDLSAPDSIFSFSMNFLYTMCKIVWSCCRIDMFSAPGAEELDDCLPLALVPGLEPAPMKEAPREYKPAMEPIVPFQEPIATLPTPEMKMLRDKIIVEERRVRKRTCKKLSGLEIPNDHLNKWNFQMLPRLRKLLQKILKDSSESCSVTLMMTGDTVDNARTTVCVTCASAKKVRAALKKYFPLESEDWDLLVLRGDVQRSKVPRKKRRRPAMTGPDNAGAPAFVQHDPNPCYQERPICGASIGAFMNEEHLPPVSYGGAILVDGMPYGMTVHHMLESPSDQEDADDQDTSGPLRSAANWPQDTPAPQNLEYMYSWSDEGPLDPASDLEFEVSEDEDGDDISLSPSLDGTFEDSYLSDGYSSDEDGPNADAAYEDEDAASIGDTPGIDPGDDPLLYVTQPAIDDVDENFFPCPEDRDDEHLASHSFGYVHASSGVRRWTRKGIRHEIDWALIKINDERIDGRNIVYDRTAVTRRDPYRQRRGEQARMPQPETIYLTNICRLEDLGGLQVHCCGRTSGLQTGQISKAMTLVKLHGRQTFSTSFCVDGNFGVPGDSGAWVFEKSSGRVCGHVLAWSDKTRTAYIAPMEILLEDIARSLNANYIGLPGSPDESSSRAYSMHPRPAPSMMDPHYQNPSYHTPRPLRGQLPVDINHLRIDDSNMGPVNTSRGLREVSTPYRGMPPILTHPRSLERQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X402</accession>
    <name>A0A317X402_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_533031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470064.1">
        <property type="nucleotide sequence ID" value="XM_025611255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X402"/>
    <dbReference type="STRING" id="1450535.A0A317X402"/>
    <dbReference type="GeneID" id="37113398"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="78" mass="8710" checksum="E063E4BE4E40DE02" modified="2018-10-10" version="1">MLIKVRTLTGKEIELDIEPDYKVSRIKERVEEKEGIPPVQQRLIFGGKQMADDKTASEYNLEGGATLHLVLALRGGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4C6</accession>
    <name>A0A317X4C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_615778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469802.1">
        <property type="nucleotide sequence ID" value="XM_025616771.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X4C6"/>
    <dbReference type="GeneID" id="37118914"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="13"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="909"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2417"/>
            <end position="2491"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="909"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="941"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2499" mass="272647" checksum="BEF5B24806584A6D" modified="2018-10-10" version="1">MTSSPSFNDMDLVEPIAIVGLSLRFPDGANDLDRFWELITDARTVARDFPSDRINVNGAYWPKTTSPVKGGHFLAEDITAFDAPFFSVSAVEAASMDPQQQLLLETSYVALENAGIPMQQVAGSKTSVYIGCFTNDYRTLYHKDLRDSAPYAATGTTTTINANRVSWFYNMTGASVNIDTACSSSLVALDLACRGLRAGQAEMSLVGGTNLLLAPDLFHILSGMNMLSPDSRCHSFDARANGYGRGEGVGMLVLKRLSKAVQDGDTIRAVIRATATNQNGYTAGITQPSKGLQEALVNDCYSEAGLDKARTLYIEAHGTGTPAGDPIEAEALGASFRASRLPGERLYVGSVKANIGHLEGSSGIAGVIKSIGILERGLIPAVADLQTVNPMIDEEQLRIQFPRSAISWPRPGLRRISVNSFGFGGSNAHTVLDDAYHFLQEHGLDGVAYVPRTETPGESSRTPGLVPVPDKAGISRTIASLTEYFDSLETPPSTEFCDSLAYTLAQRRKLKALVSSPVQSGQAPELAFIFTGQGAQWSQIGVELCAYANFRHSLGEADSYLQSLGCEWRLLEELSRPAESSRIDEPRISQVLCTAIQVALVNLLLSFNIRPKVVIGHSSGEIAAAYCCGAISARSAWKIAFLRGSLVSTLREETAVPGAMLAAGLSPSDAASYLAQSDPFLQSLSIACFNSPDNVTISGDEVAIDALKTKLDAVGIFARKLRTGVAYHSSHMYPVAEAYTDAIGDIEPGIDSLAAVVMISTVSGQRASPDILRQGSYWASNLVSPVRFLQGFQSILNKRVAKKMDGSHRSLMDIDTCLEIGPHSALRGPIKGILAAKERTMTYLSPLQRKRSGLETMLESVGQLWCLDQDTTTLVSLADLPPYAWDHSRSYFHESRVTKNYRLREKPRSDLLGEPAVDWNPLEARWGNFIKLSEHPWIEDHRINGTILFPAAGMMAMAVEAVKLTTAGERSIAGYELRDISLTAALSVPDRERGIETQFFLRRQPGGAGRDATWSDFQLCALVEDEWEEVCSGSIRVDYGVSETGVGSARVASDRVHAMQEQYSRIHNKADSSLDIETFYKQLRQCGLDFGPTFRTLIEAQWLDKECSATVADPARAKSTAIPAKIRRVWLASSGLGWQATDVLHAVSTVVAEDRRGCEVRSHALSTDGAHVLAELKGIRLTVVNDALDMADRDVAERDRMWNLVWRPDIDLLTRPEVDQWCAETLRPDGEPTDFYRDLSFLHYASLKQTVIDVAIGNLSPQPPHLQEYVRWAQGQVEHIESGQLPHWQSTWESLARDVEYRRAVEDRLEQTNAEGKAHVVVARHLEQILRGDMDPLELLFGSPILDDLYAELSNDNNSFDQLDRYLRLYSHKYPNSRYLEIGAGTGGTTAPVLRSLVGEGDPEITGALYQDFTYTDISEAFFDSAKARFAKYPDLAFQRLDVEQPLADQGYTLGSYDVIVAANVLHATSDLMATLQNVERLLKPGGKLILFEFTNPDLGRSGFIMGLLPGWWLSTESYRTRGPCVSPSTWSTVLEEAGFTGIEHEFRDYNSDGCHELSMLISIKKPSTSPLQQLLPSTVNIVTGTSTSEAGYANALERQLREKGIASRLVSMDQIQSASLGADALTIVTSDWDLNRPFLQDLSAKDFGALQHLVGQSRNLVWLTPTVDDGSAAPEYNMITGLARVCHAEVEGQRFMRVGTEPGAEPTPSQVHGLLGAIQQMLAGTPDTYEMEFEQRGGLFHINRLQLDAICQEEVHQIQNPRTPRDLAWQDAPPLKLVTDTPGLLESLTFVEDEEHSSPLAEDEVEIEFRAVGLNFKDCLIALGRVPADTLGNECSGVVVRVGSACQDRFQIGDRVCMSTVEAFKTYARSKAQCVCPLPDSISFTEGAAIPTQFVTAWTSLVEIGRLARRERVLIHAGTGGTGQAAVQISQYLGAEVFVTVGSEAKKQVLMTMYNIPEDHIFYSRDTSFATGIKNITQGRGVHVVLNSLSGDSLLASWDCLTPYGRFVEIGKKDILDNARLPMLHFNMGVSFSAFDGSIWMVERPDQAERGIRTIMELFQKGIFHVARLLQVCPVSDVHCAFATLADGKTSGKTVVEITPTAVVPTIITRKPTYVFPTDATYVLAGGFGGIGRSIARWMADRGARNLLILSRSGPKTPEATSLVDELRSTGINIQAPACDITNADALQLVLDECLQTMPPIRGCIQASMVLQDTLHSTMTHTQWTAAVNPKVTGSRNLDALLPGGMDFFILLASVSGIAGQRGQSNYAAGNTYQDSLARHRITRGEPATSIDLGAMVDNGFLAQNQSIRDRLLGGGSMVPITRAQFLSLLDYHCDPANKPTLTTCQTIFGINSPQAMHARGLDEPSWMQRPMFGFLHRVPATTGHQTSADAAGGNRARDFRAEFAQAKTLDEGALIVATGLIAKLVRSLSGLEEEDVEVSKPVVSCGVDSLLAVEIRSWFAKVFQADIPTFEILGGLSFERLGRLVATRSGLGRGWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4T4</accession>
    <name>A0A317X4T4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_397334</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469298.1">
        <property type="nucleotide sequence ID" value="XM_025607369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4T4"/>
    <dbReference type="STRING" id="1450535.A0A317X4T4"/>
    <dbReference type="GeneID" id="37109512"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000005">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000067">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="13"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY91570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="358" mass="40526" checksum="116A04D5FBA1EB63" modified="2018-10-10" version="1">MAPSDPASRAEPPTDRNVKHVVLGDLLFPTWYQSIYPEDLVSKDTDRLYVCRWCFRYSCDSHAYAQHTRLCQHRTTPPGTKVYDHGGYSVWELDGECHKLYAQNLSLFAKLFLDHKSVFFDVVSFLYYLLVFTDPKDPDNYYVLGFFSKEKLSWDANNLACILVFPPYQRKQLGKLLMGVSYKISSWERDSGLIGGPERPLSEMGRRSYTRFWEERIARYLLLQVGKTGEAEAPGSVPLKPKSPKNSKRKQTHELMTVQDIGLATGMLTEDVITALKGLGVVEPVTPAMRRKTRDSAGETGSGEETATVRIRKSKILEWAESHHMALQDPVRNEGFLGKWAPSASVEESDVDSDSEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4X5</accession>
    <name>A0A317X4X5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_462423</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469338.1">
        <property type="nucleotide sequence ID" value="XM_025607974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4X5"/>
    <dbReference type="STRING" id="1450535.A0A317X4X5"/>
    <dbReference type="GeneID" id="37110117"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="386" mass="43878" checksum="5091E4C0B2EB08AF" modified="2018-10-10" version="1">MKSPRYTISRQKACTQCSNAKVKCDRRTGNGRCMRCAQRGLPCSYLNADAPDKSPSRSHTDRIEPRPSNDAITTNTSSPGCQDRIDFSNLDLLCPINADDIRNRWIQAYTPVPGQTIKQYPTSVSAFIYQILKSYAAVGVHGRDTLPFIHPKQLITQPAGSPLTTCLSLVRMCSNALPGSADAAANILHREMYNLYELRERYNDEALFAAFQAYLIYAMVLFFRLNQACNDHFRTIMTNLQDLACASSRGGLICAADQRRARPRWEEWIVAEAKRRTLYVMYLFDSILSTQEGLPTFIGTELSGLPAPANRLLWQAGTRYDWEREYNIHMAEWMEGSLTIDELWPTPDDISETGLGRLRDRVDRWLENLDEYGTMLYAIMRCTHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5I7</accession>
    <name>A0A317X5I7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_487395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470600.1">
        <property type="nucleotide sequence ID" value="XM_025609032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5I7"/>
    <dbReference type="GeneID" id="37111175"/>
    <dbReference type="OrthoDB" id="2344991at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638:SF1">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="151" mass="15721" checksum="78147C393125E0A3" modified="2018-10-10" version="1" fragment="single">MTTLNYLPSVKPSSIAVGAIFTHTASLGILAPVFGDTYHRAQAANSKEEFLKSKEAAGAVAAWGSSLIGSSVQTYGVAALINATGTLSYKGAAYLGSLIFMASTAPGVVSQVFAEKRPLDTVAVGALSRLFETVGLSLFLTWWGTRTNPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5P6</accession>
    <name>A0A317X5P6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_533315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469598.1">
        <property type="nucleotide sequence ID" value="XM_025611305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5P6"/>
    <dbReference type="STRING" id="1450535.A0A317X5P6"/>
    <dbReference type="GeneID" id="37113448"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="481" mass="54819" checksum="2E47556C0538B775" modified="2018-10-10" version="1">MVLLNRDSQHPLKGLQPPVVHIPREVRRSEHVNEVYSQVLDEYGPVVIVPRHGRNEYVIDHRYAHQVLTDTQNFTFEKAAFEFLHLGFIALFDNGVFVRDVDNLIEHNVQPRMNAIIERILPVFEACFDRMASEVPSPVEDKSPVEFQDIFSRLQHAIAHAMVIMILGPAHSSPVTAGHFAAVAVAMAHMTGMHENTHEWAWFPSLWVLLNGLRAVLFTIVPQFFFAIVPTLWKTRHEHLSNGLSARHGEYIPLFDLLLVKNYHQRSGLCALAGFGWSVVLCVGMIFASIHQTVVAGTWILITLVQKQDGYLPAIREEWETVINANEPLSVKKLTQLTLLDSFMREVFRTKGDTWGPVRQTTRPVQVGPYTLPKDAVCMVLISRAHQHQDNYGSDGRIFDGFQWEKKAKPAVQSSPEFLAFGLGRWACPGRQLAVHEIKIMLYLFFSRFDVRVKEGSFRVVNWINTTSVPPEVTLLVRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X632</accession>
    <name>A0A317X632_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_317348</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470794.1">
        <property type="nucleotide sequence ID" value="XM_025606876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X632"/>
    <dbReference type="STRING" id="1450535.A0A317X632"/>
    <dbReference type="GeneID" id="37109019"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF37">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="394"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY94033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="457" mass="49772" checksum="CC7ED65B53EF16DB" modified="2018-10-10" version="1">MRLFRDFLHGGLFLNTILFSQLSRAIDLDISSTSSLKDAASQSAYGSMTWYHGNETGQIPGAFPTKWWEGSALFMSLLLYWYYTGDSTYNAEVRQGMQWQAGDCDYMPNNYSSYLGNDDQMFWGLAAMTAAEIEFADSSSGYSWLALAQGVYNTQIDRWDTKTCGGGLRWQIWPYEAGYDMKNSISNGGLFQLAARLARYTSNDTYADWAETIFDWAASTPLLNNQTWNVADSTDVDNGCTTQGNNQWSYNYGTFLMGAAYMYNYTGKAKWKTAVDGLLNVTLDTFFPASYGGNIMSEVLCEPAEVCNDNEILFKGLVTGWLGFVALVVPSTYDTILPKLQGSAVAAAASCTGMNNNTCGVRWYPKKWDGWNGMEEEIAVTNVLSSALVNTKKTAPVTSSTGGNSTSDPNAGTGDNTGSDSDSLSAITTGDKAGASILTIAFVGMWGGMIAWMVIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X654</accession>
    <name>A0A317X654_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_532032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470835.1">
        <property type="nucleotide sequence ID" value="XM_025611033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X654"/>
    <dbReference type="STRING" id="1450535.A0A317X654"/>
    <dbReference type="GeneID" id="37113176"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="118" mass="13838" checksum="3BB08697BEF5EE2E" modified="2018-10-10" version="1">MTDLSKTAIILVDPYNDFLHPDGKLTSKLKDLEEKQTVKHMTELVAMARLHHIPIFYGLHQQWTPNSFHDWRHMTPNNVKQKHIRFFEEGTFGSRIYEGLEPDPTNGDVVVSRHWNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6A2</accession>
    <name>A0A317X6A2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative UV radiation resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_321941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470905.1">
        <property type="nucleotide sequence ID" value="XM_025606907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6A2"/>
    <dbReference type="STRING" id="1450535.A0A317X6A2"/>
    <dbReference type="GeneID" id="37109050"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000323">
        <property type="term" value="C:lytic vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035493">
        <property type="term" value="P:SNARE complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15157:SF5">
        <property type="entry name" value="UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="616" mass="68316" checksum="229F060CDDB3454F" modified="2018-10-10" version="1">MALSATAWGVWDIDDNASRRERPGLFLPNRKLRHLQGISVRNLVVSPPSRPRGKTIDDEDVPNSLHTPLKSLAEDTPRSLHQSRSFTDLKSSAAGEGRPKREQPPPLRQWHRRNTLPWNAPDPRARQVKLEEITSSRMADTWFSIHCDEVDEPVYVSEVVDHATNPSFRAFDLNICGPLVSRMNQITVKIWARTAAMEEYLLLVELQLCLQSLQYLGKSLDNFHQPLPPNSILFHFADGVYTNLTDIPPVVTPLPTRHPRSADGATVPTSSYDALMRLANLDECIQDALTTRDKLESEISSILEQNQRALATTSGASRARDKLALTKHAVATERKQFRTAAKRKEELIASIRARREAMDLGRQTQAKARSHLPDAQVKLGSSVKLLEQNTDEGKGQIRRIAEDLLAIYPIEPIPDKPLAFTIAGLALPNSNFTDVDRDAVAAALGFTAHLVYLLSFYLSIPLPYPINPNLSNTLIQDPVSASLPQRTYPLYPVNVQYRFEYGVFLLNKDIEFLLNKQGLRVLDIRHTLPNLKYLLYVLTAGTSEIPSRKAGGIRGLLPGRLTPSLSRRGSEASSTNGEVVLARKVLGPVSKANGEMTPDKGKRAMSSIADAASSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6Z7</accession>
    <name>A0A317X6Z7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_553826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470712.1">
        <property type="nucleotide sequence ID" value="XM_025613678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6Z7"/>
    <dbReference type="STRING" id="1450535.A0A317X6Z7"/>
    <dbReference type="GeneID" id="37115821"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="66"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY93951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="434" mass="49850" checksum="3B7E707F1A6B5FA5" modified="2018-10-10" version="1">MPGSMAKLPFRPQLRTFSLLYKPRTTFRGVSLELPSDTPIEEEVIPGYDPRSYFPVEPGYVFNQRFEALSKLGWGSGSTVWLVRDLHRWRFQSERYLTLKVGNCDFKDKEAASHEARIEDHIAHANPHHDGCNYVRTWTERFEEQSAHGTHIFLAYEPMREPLGLFQNRCRNQRLPLGLLKGYVKLLLKGLDYLHSECNVIHTDLKVDNMLVTFENSSVLQDFVQAQPSNPMPRKVKNRRTIYLSHNDFGPLRSFYILPKITDFGLAHHQGTSSVLNRHPIQPDEYRAPEVILGAGWTYSADIWNLGLLSPAAHLAEMIALLGPPPAELKRRERDGLNWNWAPAVHNDEGKLCSTASDWFGGPFFDENGEFMHNHLIPHTLKIEDTVKALDGEQKDQFLSFARKMLQWLPDDRKTAKGLIEDPWLSDDSIRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7Z8</accession>
    <name>A0A317X7Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_610283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471507.1">
        <property type="nucleotide sequence ID" value="XM_025616605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7Z8"/>
    <dbReference type="GeneID" id="37118748"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF3">
        <property type="entry name" value="BETA-LACTAMASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G07500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="24"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="417" mass="46672" checksum="38E19D18CA77D3BC" modified="2018-10-10" version="1">MAKLQPTAVPRLKAQIDAVTGTPDGIPGVAFAAVNKSGDVIFEHASGKLGFGRPEPMELDSIFWLASCTKLITGIACMQLVEKGVLNLDDVELVERLSPELKAVQVLQDDGTLVPKEREITIRMLLTHTAGFGYSFMNKKLLNSYGARGLDEFTGSYYEILSQPLIHQPGERFEYGINIDWVGLLIERATNTSLNDYFQENIFTPLTIKEINMFPTPAMLSRLCFMNKRTPDGKLSLNEQGHITRNQFLAQTPSERKQLFNHGGHGLFGRPSEYIHILSTLLNDGTHPKTGNKILEKHTVDEMFTNQIPQFPDFGRCAINPPRLDLSNPTSDFYPEPNNPPQGWGLTFFLHVQDSHTHSKGAAWAPGLPNVYWWCDRQRGIGGMIAAQILPWLDKEVLGFWVGLEEAINGAIEEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X800</accession>
    <name>A0A317X800_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_583050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470438.1">
        <property type="nucleotide sequence ID" value="XM_025615527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X800"/>
    <dbReference type="GeneID" id="37117670"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19503" checksum="7C0DF87E4F6E3E5E" modified="2018-10-10" version="1">MRASPDMRERYSASRIIPECHLRKPKAQLEARTGDTANALYIHIKSTGYHRLLRLGDLDRTPNLDSIAPILAFFICVILRASTRISSVEKKQTCTWSITSSSGKRGGSHLRFGQLPTLIGSWAASCISHQPVTPMGSIADQLQVRIGSIVPRSLKRAAQSLDWAREGAEYLCSNGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8G4</accession>
    <name>A0A317X8G4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_276553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471252.1">
        <property type="nucleotide sequence ID" value="XM_025606597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8G4"/>
    <dbReference type="GeneID" id="37108740"/>
    <dbReference type="OrthoDB" id="4186330at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="321" mass="35482" checksum="A6DA4D606AFC9CDC" modified="2018-10-10" version="1">MFEDFSFSSPSSTRPSRLALEGDDRLMVDSDSALISPMSSRCPSPRSQRFPRSAPRSRSSYLRSAQPPTSVPLSAYDHKRLSISTLTRKLHEHTLQNQNGIQPDEGRFDRPASPTPSDLGISSKFPGYVLTPPDTDHDDESLTSGSLSPQSYSPFLSPTSAPADFPADNMDLSAAPGLGGPDAWSVRAQRQQISRLQCNQTDVESIRRAFVSDDEVMRSAMCRDSICEDDCHPSSLPPQSSPRRRALTLSRNRFRNQSSDTSALEPRTRRKSSVSALSSHRIEKSYHCSTRDMHKKGEQGLRRKSLVSAALASMVEQAPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8I8</accession>
    <name>A0A317X8I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_562643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471674.1">
        <property type="nucleotide sequence ID" value="XM_025614304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8I8"/>
    <dbReference type="STRING" id="1450535.A0A317X8I8"/>
    <dbReference type="GeneID" id="37116447"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000318">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="513" mass="56667" checksum="857996BBF223ABF7" modified="2018-10-10" version="1">MEMHPSRTGVDAQTPSKEDVDFVESTETGIPSTYADIVASRLSKAHRDYLMERHGTLELDPIPSMDPADPYNWPSWKKVANLLLVAFHACMGTFAAAGIIPAYETIATDFGVTVNDASYLTSIQIAILGIAPVFWKPLSNRWGRRPVFLLSLICSLICNVGCAESTSYASTAVCRALQAFFISPASAIGSAVVMETTFKKDRARYMGVWTLLISLGIPSGPFIFGFVTYRLGYQWIYWILAIINGVQFVLYLFLGPETRYIGGDQDPDQPAWVREYAQLRRIDPTPLSFKEFFRPLGMVTHPCVAIPTAAYAMVFCLGNVMTTVEVPNLLQSKFDLNAEQLGLQFIGPIIGSVMGEQLGGVLSDRWMNMRAKRIQRKPEPEFRLWLSYIGFTLCIVGLIVFLVCTQNSKEGHWNVTPIVGIAICAGGNQIVTTVLITYAVDCYHKEAGSVGVYITLVRQLWGFLGPFWFPSMFESVGVAASAGVCAGLIAGASIIPILILHWQGRTWRPPIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8T1</accession>
    <name>A0A317X8T1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_582400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470748.1">
        <property type="nucleotide sequence ID" value="XM_025615476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8T1"/>
    <dbReference type="GeneID" id="37117619"/>
    <dbReference type="OrthoDB" id="4521923at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="728" mass="79627" checksum="2AD75854598E2E60" modified="2018-10-10" version="1">MSPSGTQISLDDLSHRSSRPRPSQEDNRQLLPSSASSTSSRRGSSDSTSRASNAGLQPDASNNGDHSDSDSGVTAESHDDSESDDSIPLRTTEKRKWRWKHLVMDSGTDEPYQLHDDSATLTRLVFLRLVAVTIIIGAIVLGARGQSFDLASHTVENGIVVDQDAQLAIIGLANTILQFLTQEALLHISATLITKWMTGKGEKGASSVDFDLLDEFKKPWTAASKLKERCKIGTRKSRAWLQFIGALVVGISILLLGAAMNTIAIPKSRWWPDTRFEAPQPPDDRFYFVNQTSRVASVSRMPLWGQAWEMIREGGTASWEMAHTLAAYRSLNALSKLYDTFNNEAGWQSIGDNDAPTFSAIEVTNASTPSIRSMAMHGDLAIAMYNQQKAQNSHSWARDSTGWYARLFMPGILLDTSCIPNNDTLATGSWTATTSSTNSTITVTIGPATNTSTSTGTFNGAICYINVYQAQVALQQWFYSGTGNYDYSINNYGADMYPEISYLDPPSTTETLAISTETTSWFEAIIPNLQAFSTNKEVLNLTSLAVLLADDLVSFNRGYSQLDGLAAVISTIFTDMVTSFDWTYAVSSGNTTMQGPIRWQIYGSGPRLPWEWVIAIVLGVGIGVQVYDLVLLGWWRGLAKGPWLSLDGMLVAANKAPMMKVLQNGKGGGYVSDEARQARFFVRQLASDLEGQREGDAVLVSGEELQEEEGMYVELQPGKAYREQATAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9N1</accession>
    <name>A0A317X9N1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_508280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471970.1">
        <property type="nucleotide sequence ID" value="XM_025609656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9N1"/>
    <dbReference type="STRING" id="1450535.A0A317X9N1"/>
    <dbReference type="GeneID" id="37111799"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="618" mass="69655" checksum="B44472CED453D6F8" modified="2018-10-10" version="1">MTVPDASEVTLPLYRPAKPVPFELAQHAAIFFEERLYTQALDFLLNILTSGTVASAPAFTPPVQQLAVAATLLVHPSTTTRAKTTEEEEAPQAALRLLRLTNTLVGPIASKLGVAFTFNHFDAPRHTRRRPAEEVPVPTGLSSEDTKPLNLDLSQKHSIWSSAEDFWHVVGWAFNCSVHHRQRWARWQVWLEIMCDVLESDWNERLRQQSEVKPSDTTTTTTKTAPTASPTKTRSKKKHNPKGQDEDHSRQILKDSLIFRYISGASATYGRNRRIVRSIFADGGSTSRNEFREVFHNELKHAKTDTNNSKKRSAQVNIDEEEFGDYLTDDDEIEEDDNNEDEEATDPDLNLTTSTKRRQPKRPRRAPRTKPRKPVALGPGINTPPGPYGGSAPSTGIIVPIEELPTKHIPYMHGDVGFFGGMRSLSLRQRLLYLLSTVSESLPDDFASLEDLYHLFAENIRHLPLPIFQAFVSPSTLPYFSPAAKTTLCEFLLFRMRETAAPDTDEEYLNQDKLERCFLPYMASTASISDNAKMSIALESLIILLADSDMLRITPELRDAVLEGNHRRITRARGEARRGGQEALQWADDIERTWLLESGERLLLLVDEILCGKKAYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9Q1</accession>
    <name>A0A317X9Q1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PfkB family kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_530828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471692.1">
        <property type="nucleotide sequence ID" value="XM_025610762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9Q1"/>
    <dbReference type="STRING" id="1450535.A0A317X9Q1"/>
    <dbReference type="GeneID" id="37112905"/>
    <dbReference type="OrthoDB" id="204058at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004454">
        <property type="term" value="F:ketohexokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01939">
        <property type="entry name" value="Ketohexokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000072">
        <property type="entry name" value="AT09463p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052562">
        <property type="entry name" value="Ketohexokinase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034093">
        <property type="entry name" value="KHK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774:SF3">
        <property type="entry name" value="KETOHEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42774">
        <property type="entry name" value="PHOSPHOTRANSFERASE SYSTEM TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="314" mass="34588" checksum="04BAC59A624C6EDB" modified="2018-10-10" version="1">MSLVAIGALYVDTILTTPHYPGEDDKLRASKISRRRGGNCPNTLEVLQQLITHDSSTAGVALDLVSILPAESSTASQQIQLAFKPHVSLSHCIYRDGFEEPASSYIIKSESSGSRTIVNYNELPEMTVEEFTQIADRLHKASWFHFEGRIPLVTLSCIHYIRQQYPLAKISVEVEKPGREGLQELAEEADVVFYSKSWAQGNGYQTAEECVEKQSIVTRKASLLCCTWGQSGAVAFDIKTRSLIHRPAYSAADFQVVDPIGAGDTFISGMLYALLCRGDDWDLSQKLGFANRLAGMKVSQEGFSGLARALESFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9U3</accession>
    <name>A0A317X9U3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_273453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471173.1">
        <property type="nucleotide sequence ID" value="XM_025606579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9U3"/>
    <dbReference type="STRING" id="1450535.A0A317X9U3"/>
    <dbReference type="GeneID" id="37108722"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="496"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="507"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="548" mass="61678" checksum="A220305E80A9039A" modified="2018-10-10" version="1">MAEIAALTFSSPTDFYEIMDMLDKRLNDKGKNWRHVLKSLKVLDYCLHEGSELVVTWARKNVYIIKTLREFQYVDEDGRDVGQNVRVAAKELTSLILDEDRLRSERSDRKLWKSRVSGLDDQGHGHESPRRERRERRRPANDDEDAEYRLAIEASKYEAEEERKRRAKEASGAEDDEDLARAIKLSKEEEELRKRELEESNAQSLFDDAPAQVTQAQPTGYNQGYQQQSAVDWFGNPINPQQPLTTGYLNSQYAQPTGFQGQMTGMPNGYTNGFQGQPSAFDPNPYGQSQNNFLQPQATLQPQHTAFNANNPWGTDVFPQQQQQQQQHQQHQQHQQHQQPQPQSQQHQENFLSAGTNNPWAANTPADALKPMPTGSNNPFAARTQFQHQPQPKPAMTGPPSLNALAEERVTTQFNPIANYQTAPQSLAPPQQSFGPPKSASPQMQDPHRAHLNALLASGEGQDTFGNVGDLRIPSQHTAPGTFVNSAGQGLDRLRATRTGNNPFYSQQPQQQQQFVPQQTGFTQPANNPWGGQQTYHQPQQGGSLIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9W1</accession>
    <name>A0A317X9W1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gaa1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_457506</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471193.1">
        <property type="nucleotide sequence ID" value="XM_025607750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9W1"/>
    <dbReference type="STRING" id="1450535.A0A317X9W1"/>
    <dbReference type="GeneID" id="37109893"/>
    <dbReference type="OrthoDB" id="445301at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000121">
        <property type="entry name" value="GPI transamidase component (GAA1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007246">
        <property type="entry name" value="Gaa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13304:SF0">
        <property type="entry name" value="GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04114">
        <property type="entry name" value="Gaa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="747"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="831"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="7">
        <location>
            <begin position="64"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="676"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="676"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="904" mass="100525" checksum="32E73329FA85409A" modified="2018-10-10" version="1">MATPAALPPLPFNPSRVRSYVLRLPLFTRLVLLAILVFWLLELQTVWSVVQWGSVIPEEIGFGSMYRLNTYPFIHLGFFHTFLNVLALTPLLERFEAEHGTLTAVALFIGPLSTLPAGAYILVEKFLLHRNTAIVGSSIWVFLLLGSEAIRTFKSNPYFSFSLGTTKIPTWTSPLFACALVSILVPNTSFLGHLCAILVGYLLGLGFLKIFVPPEKVLRWIEGKLNLLGRLPHYVSVDQKTYGRYGVLPTTTTGGERGTPMSFLGSSQRLGPTTIAVIRKLRSNPNFLFVHLPHILSFICIVSGVVWLLLLPLNDYSRQTYISENALLPGQVHAYFSGSEQHIFRGYKKELEGILAGQTEDGQEGWNDKFTPAVSDKIQSILKATGLKVATQNYEYTSSGIKHQGQNVYSIIQAPRGDATEAIVLVAAWKTVDDELNLNGVTLALTLARYFKRWSLWSKDIIFLFPPDSKAGTQAWIDAYHDMQPAFVQPLPLKSGALQGGLVIEYPFDHRFESLHILYDGVNGQLPNLDLFNTAVSITGGQMGIGTNLQEMWDHDDSYEMRLETIMRGMVKQGFGYATGPHSSFMPYHIDAIMLQTKGDGWQDEMALGRTVESLCRSLNNLLEHLHQSFFFYLLMQTNRFVSIGTYLPSAMLIAGNFTIMAIALWLRTGYYPGRQQSPQASKSTKEQAATATENRDDKQSPAQTDASNIIERQLALPLTLVVGLHLLGLIPLYIFNNISHQYYPTATYTSILANIILPLLLAAILSHGLNPKPQQYLLIKSFSLLMLGLFLSTLATLNFSLSFMIGLLCAPLTFVNRINPHTTSRPVRYILAMLGLGLLNVLSPSVLLLAACSYFGVDVETVLTQAAFGWDVWGVWTQVVVWCVWWPAWVSGCALVGFSLFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAD4</accession>
    <name>A0A317XAD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Small ribosomal subunit protein uS7m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_571126</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472307.1">
        <property type="nucleotide sequence ID" value="XM_025614855.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XAD4"/>
    <dbReference type="GeneID" id="37116998"/>
    <dbReference type="OrthoDB" id="10260443at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14868">
        <property type="entry name" value="uS7_Mitochondria_Fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000006">
        <property type="entry name" value="37S ribosomal protein S7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047988">
        <property type="entry name" value="Ribosomal_uS7m_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="940"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="974"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1027"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1117"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1156"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1198"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1223"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1251"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1290"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1335"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1389"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="15">
        <location>
            <begin position="541"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="461"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="651"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY95546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1422" mass="156604" checksum="22134BA2D44ADFD3" modified="2018-10-10" version="1">MPPRLNLFTARAVPVLRQACPSPANNSAASRRSFATILNANRPCAASTGHGLKSGLSASMRVQRRCNSSDGKDRAKGPTEDPLPHVSEEAAEVSKIMDKKCDGTPASPELEQGTPVSEILQRDKEAQKHAPKVMQDQMARPSGTRSFSTSARRLQPEVEGNNFDKASAAMVASMLSEVNQQAAELHPGLKFPAPQSIPRTENFRKRYETIVEQFTKLLMKDGKLSKAQKNMAFILDHLRTAPPPQYNPKRRLLPGPPGPQLPLNPVLYLGLIVDSVAPLLKLRNQKGIVGGGVSVQVPAPLALRQRRRTAIKWIIDASEKRKDSQFAQRVANELFAVAEGRSGVWDKREQVHKLGVAGRSNIALVHCLVLELRLIFMVDLQLSPTTTTTTTLLYKWMQFGSYGRISIAPPPLSLPRSSLPSFLSDTVSSNAGGRTWARIASARGAFTDDNDVTPRGQTIELVDYPDSPATPSHQSHAPDPRTTAHTQLTDRPSEDCPQRRTDDKEGGIQPTLRKKPVRIKYWIEALRRHSHRHNASGSDKMKFSHSLQFNAVPDWSAYYLAYSNLKKLIYSLEQEVHRSTGQEHVDVESAPLLDGGNLNTDAIFRRALDAELEKICSFYQAKEAEILAEVEDVVKDAEEYANRADSINVDPMSESMIKARTTSSHSRQRPGSFFRQSHERRHSTFSETLADEEDDDDDLDSDDEPASLSNQNRSQSHGAESSNPDGCRTDDMRDSGLWAADSRLLGYGGPSAHRGGAQDERFSDPTVVDLYNAGLSLKKRAVAAYVSVCGLKSYIQLNKTGFSKALKKYDKILDRNLRREYVNSVVSPAYPFTDSTMGLVDDNINKVEEVYANIVTTGNISLAKRELRLHLREHVVWERNTVWREMIGIERKAQAANVGIRRTLLGGDEDPSRARRQGDEQEAMPKVLRTPFGAVQIPQWLFSLSFGTLVFILLVFGILLSAPIMEKPEQQNCLAMLVFVSLLWATEVIPLFVTSLLIPFLVVMLRIMLSEAKPHERLGAKDATSAAFSAMWTPVIMLLLGGFTIAAALSKYDIARRMAMFVLSKAGSNPNVLLLTNMFVSMFLSMWISNVASPVLCYSIIQPLLRNLAPDSSFAKSLVLGIALAANVGGAASPIASPQNIIALQNMYPSISWGTWFFISLPVCILSILLIWVLLVVTFKPGRETAVAIRPLKDKFTGVQWFISIVTLFTIALWCGSHQLEHIFGDMGVIAIIPMVLFFGTGILNKEDFNNFLWTIIILAAGGLCLGKAVTSSGLLHTLASGIRERVEHLSLYGVLLVFCSLILVVATFISHTVAALIMLPLVRQIGISMADPHPNLLVMASALMCSVAMALPTSGFPNMTAIMTEVPQTGQRYLQVRHFFTRGIPASLMSFVVVVTVGYGLMYIAGLFAISELAISGFAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAI1</accession>
    <name>A0A317XAI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_131191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472357.1">
        <property type="nucleotide sequence ID" value="XM_025605645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAI1"/>
    <dbReference type="STRING" id="1450535.A0A317XAI1"/>
    <dbReference type="GeneID" id="37107788"/>
    <dbReference type="OrthoDB" id="19806at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="49"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="511"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="801"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="857" mass="95049" checksum="4DFE3B8AB9B90F96" modified="2018-10-10" version="1">MPPPATQTGGQAAPPTIHPREPARPFNTKNPPSTNPSGSECPSPHHGHQKLVFTDPVALRYLEEDSEAVVLHRRLSLVGYEVFIVEQWACTRIHPTFIITTYTGDLSHKVVVGVLSVPTDESKWSPRMKMYFSAVTQCQARKMETPLGTLMVTDLNVFPLALTLIPVPDGDVLKHKEDFVVNENLKRLGCSGRSGLKLQPPSPATEAKFHHLYRTSEKVPLYSAVMELVKQCQIALMMFGKLAPEYVDGLLCDVTEAAINDWWTDTGMDLFNIEPSDNMIGPISVAGLLGTLMGARNRLHAFGAPVGKDAFDFSNLERGIGSFQKSQKLKRTRRLDRQTLDRLHRATAKAANAEGWTEAVKSTMAELSGHGGEMVMGMVRGREKGGIADIETLDIDNFAHLVTGERAKWLWRGKPRKGGIGDNYAGGAPAADMVFTTDDQGGYFWTSRRRPSHEDLATDRILQSSDRSWRPAESAASLDDKDQNLGRLVRQGVSGKVSDARAGFGRFKDAVGLRSHPHKQSRDGIDLAGDSSHLPPIDSDTELSQSKKSEGGAPTEPDSVHDNEAPAPADDAQVEPPPRTILPQSPNSRAPAITVETVPSTADSESSRKVSVARAEDEGPDLERWRTLSTDVSADREQTSEVGIMLLRRPQSCAELSPERDSRRLDNYWPRHLSFSTVEEVVLGWEGLGGEAFKETPDTLLEEAIIQEDILASDARIFSSRIQELSEYTVPWVEQQVASVDDLSRCLHESHEKVNAAYLERLATFQQVRGRSSDLLTEEHTQLTDYMRRVELMGAKLDYELHVLDSRVEDVETNLDEFERHVNAIETRVKLLIRGEQEKQSNSWFSWFGRITGLSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAR0</accession>
    <name>A0A317XAR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_530210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472246.1">
        <property type="nucleotide sequence ID" value="XM_025610634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAR0"/>
    <dbReference type="GeneID" id="37112777"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="99" mass="10817" checksum="7A08B60597D21FE2" modified="2018-10-10" version="1">MGLHRIQWLDILNIAILSGTQRPTPLQAPTPERPEPDVSPKITTRLLAPWQATPPHPSYLRSPSLSGPRPECLSNISAMEERSKRTSNGLNARASQSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAV9</accession>
    <name>A0A317XAV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_552509</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472400.1">
        <property type="nucleotide sequence ID" value="XM_025613604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAV9"/>
    <dbReference type="STRING" id="1450535.A0A317XAV9"/>
    <dbReference type="GeneID" id="37115747"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY95639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="312" mass="33208" checksum="D23D412A20E4B0C1" modified="2018-10-10" version="1">MGGKSATKAAYFDKLKALLDEYKTVFIVGVDNVSSQQMHEIRLSLRGEGVVLMGKNTMVRRAIKGFVTDNPEYERLLPFVKGNVGFIFTNGDLKATKEKILANRVAAPARAGAVAPGDVWIPAGNTGMEPGKTSFFQALGVPTKIARGTIEITTDLKLVEAGSKVGPSEATLLNMLNISPFTYGMSIAQVYDQGQCFGADVLDIEESQLLEAFTSAISTITTISLAVGYPTLPSVMHSLINGYKKVLAVAVETEYSWPEIEELKDRIANPDAYASAAPAAAAAAPAAGAPAAEEKEEEAEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB93</accession>
    <name>A0A317XB93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_621312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471628.1">
        <property type="nucleotide sequence ID" value="XM_025616994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB93"/>
    <dbReference type="GeneID" id="37119137"/>
    <dbReference type="OrthoDB" id="4526540at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="82" mass="9389" checksum="12407407E8870C19" modified="2018-10-10" version="1">MSQNTNHEGVFERLFGHHPHHHQNESQDETNQGTEGQCSNQQKSTGTQPSHHGEESEMDKLKDYVHEDEELEKEGQTYGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBA9</accession>
    <name>A0A317XBA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_456032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472162.1">
        <property type="nucleotide sequence ID" value="XM_025607686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBA9"/>
    <dbReference type="STRING" id="1450535.A0A317XBA9"/>
    <dbReference type="GeneID" id="37109829"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16555" checksum="F6D437526369AE9F" modified="2018-10-10" version="1" fragment="single">PPAPKSCTCGTNTTTALSLNCKYDSLAAAWLPPHCRDDALTAEFDRSGPGPNGTWTYYADDHHTIPMSVEEVAMLANNQSARVKMTREWHVVHCLFYWRKMVRIRDRVVGGEEVLLEPSFDNEEHVRHCVGVVLGESWGTEARVALVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBY8</accession>
    <name>A0A317XBY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Patatin-like phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_601186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472790.1">
        <property type="nucleotide sequence ID" value="XM_025616369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBY8"/>
    <dbReference type="STRING" id="1450535.A0A317XBY8"/>
    <dbReference type="GeneID" id="37118512"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07199">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF8">
        <property type="entry name" value="PNPLA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="484"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="5">
        <location>
            <begin position="488"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="5">
        <location>
            <begin position="721"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY96029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115096" checksum="94E5A67127F051BE" modified="2018-10-10" version="1">MRRTEDIGWLDVGLAEDGRFIIHDHNRLTQTLGMLPNPDSQIPSLCLFLGAVSKDKALQQIFPQNNIRRHKSGSVIGLRYDITSLDSPTPILFADGDPQLNPIPGKRPELGVSYPVIWDAATAKAVLHVLWCRLMFIFADVVCIFADDFASFSELVEFLIECLVGPSASSLPSAVRPRLVVVLASGLDVSKETMLTEQLYGQNGRTSSRSLGGAFSSINMIRLGDTCLSERVRHERLRALVQGQLADMQLVRHDHRAQFTALHLDGLFQSALRHIATHVDHPFNFIRATRETRKIPPNIIDHLAHYCEIGQSAGYTYDELAPTIASTLLMDFYIPGAVVYEPRSVFRTLYRTSVLRGICAFMHGALKVATDDLLGLIECNMVYLFDKLEREAIDSATLRKQELLSYRGRLCRLRSTRICLYCLLHTAQHSLSCGHTICDICAQVFGRPATDADYQFTITECLYCLYKSPLVVDVLPPTMNPTILAIDGGGVRGVIPLEFLILVQEKLGPSCSIHELIDLGIGTSSVGGLSILGLLKMGWDVQTCSTVFESLARRIFQSRRSSSLSQSLRSNSGGRYLISCFHKWLLWLLYDGCYDSHVFDSALKEAFGEQTRLFDSRAHISSRQSSSGTRLGVVAASIAKNTRSFIFGNFNTPEIVKDGCIKCTQLPCNCEPSNIEARDLNIIRPAQADLEPSIWEAARATAAAPFFFPPAYIRGIGSFQDGGLTDNFAADIARRLCRQIWPSRKQPARLLSLGTGRMSQTSDKSPQFRHVFRDGFLRRGFDAWMSSMDTEPKWQAMISHLDPIQREAYTRFNVQLQDIPDSIDNIDTMDEYRNLVILQPGSARLAKDIAIGWLVARFYFVLDLMPETTTAPFWCHGTIRCKGNATHIVAALQSLWSQRVDFTTDTDALGRFNGLEDICSACMRYRKPVSVLVHHLEETVNIHLRAGTQRHWRINGFPECMQSFIAKQELRTVFGRTAHDCPTAAACSECDSYEISLRGKRRKRDSELSHSGQRNKRVCVDVGQFRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCK6</accession>
    <name>A0A317XCK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_591836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473010.1">
        <property type="nucleotide sequence ID" value="XM_025616133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCK6"/>
    <dbReference type="GeneID" id="37118276"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="125" mass="13451" checksum="8D6FE3C33ED2663E" modified="2018-10-10" version="1">MPGHVITGDMVGGKIFTGDKVMGNIVKKKSQKKTKKGREERRRDGMVEDTTENSPPPPYTPASTDQGNDKAPNEDENNSPTSPHVHAMADLGNENPVNESTISANASAGDQANDHASERDPAKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCM3</accession>
    <name>A0A317XCM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_541191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
            <location evidence="5">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473127.1">
        <property type="nucleotide sequence ID" value="XM_025613036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCM3"/>
    <dbReference type="STRING" id="1450535.A0A317XCM3"/>
    <dbReference type="GeneID" id="37115179"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0134">Cell wall</keyword>
    <keyword evidence="4 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016193600" description="Hydrophobin" evidence="5">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY96366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="163" mass="16227" checksum="DDFC6066435D6CCB" modified="2018-10-10" version="1">MKFSITAAVLAFAATVVALPGTPSAANGNGIANGNGNKGNSDVRFPVPDDITVEQAEAKCGDQAQLSCCNKATYAGDTTDVDSGILAGTLGNLLGSGSGSEGLGLFQECSKLPIEVPIIGVAVQDIVNQQCKQNIACCQSSPSSADGDLIGVGLPCIALGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDK0</accession>
    <name>A0A317XDK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NCT transcriptional regulatory complex subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Negative cofactor 2 B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_530073</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B. The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Forms the NCT transcriptional regulatory complex with nctA and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473457.1">
        <property type="nucleotide sequence ID" value="XM_025610603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDK0"/>
    <dbReference type="STRING" id="1450535.A0A317XDK0"/>
    <dbReference type="GeneID" id="37112746"/>
    <dbReference type="OrthoDB" id="601405at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22905">
        <property type="entry name" value="HFD_Dr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000019">
        <property type="entry name" value="Negative cofactor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042225">
        <property type="entry name" value="Ncb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46138:SF1">
        <property type="entry name" value="PROTEIN DR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="9">
        <location>
            <begin position="13"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00053814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00065193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY96696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16176" checksum="4D4EADF09DF4AABE" modified="2018-10-10" version="1">MSDREFMSNDDLSLPKATVQKIITEILPPSSGQTFSKDARDLLMECCVEFITLISSEANDISEKEAKKTIACEHVERALRDLGFGDYIPDVLAIAEEHKEQLKNREKKQSKMEQSGLSEEELLRQQQELFRSATEKYHAAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDW0</accession>
    <name>A0A317XDW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_481773</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473495.1">
        <property type="nucleotide sequence ID" value="XM_025608868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDW0"/>
    <dbReference type="GeneID" id="37111011"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="129" mass="15056" checksum="249346B660C495CD" modified="2018-10-10" version="1">MSPPQRLIRFDTYVKRHPSLSAEEFHEIWTNEHAQLLKKWLERHGVYRYTLFHTPPAMASEYLGGGDQGLEFDGHAEVLLESWDILARLRADPYYQEVVEPSENKLIDKGSVKRRVGYEEIWVTEGKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE75</accession>
    <name>A0A317XE75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_530666</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472688.1">
        <property type="nucleotide sequence ID" value="XM_025610722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE75"/>
    <dbReference type="STRING" id="1450535.A0A317XE75"/>
    <dbReference type="GeneID" id="37112865"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY95927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="411" mass="46184" checksum="748D94C08DDA4AD4" modified="2018-10-10" version="1">MTTRYRVEYALKSHRRDQLIEWIKGLLAVPFVLHSQPTAVYQEHSENLIAVAADTHQRYAEIFRDVEMLIRDHISHEQKAAPGNSKLKLLVPSVGTFFTPLFLVDAFRYQDRQRFISRRRFVAPSFNDVRLILNSAQLLGLARSTGVDLVTFDGDVTLYDDGACLTPDNPVISRMIRLLLQGRKIGIVTAAGYTEAERYYERLKGLLDAMHESVALTDEQRAGLVVMGGESNFLFRYDGASPHRLTYVPREEWMLEEMSTWADGDITELLDIAESSLRACATNLNLPVAVLRKDRAVGVYPLERSKISREQLEETVLVVQNTVERSAVGARLPFCAFNGGNDVFVDIGDKAWGVRACQRYFGGIERERTLHVGDQFLSAGANDFKARLASTTAWIASPAETVQLLDELQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEX7</accession>
    <name>A0A317XEX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_529646</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473018.1">
        <property type="nucleotide sequence ID" value="XM_025610491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEX7"/>
    <dbReference type="STRING" id="1450535.A0A317XEX7"/>
    <dbReference type="GeneID" id="37112634"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000048">
        <property type="entry name" value="Proteasome subunit alpha type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY96257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="279" mass="30219" checksum="0E22E823D42411CE" modified="2018-10-10" version="1">MADRYSFSLTTFSPSGKLVQIEYALNAVNQGVTALGIKATNGIVLATEKKSSSPLIDPPSLSKISLITPDIGMVYAGMGPDYRVLVDRARKVSHTGYKRIYNEYPPTRILVQDVARVVQEATQSGGVRPYGVSLLIAGWDEGVEPESGEAQRGDDEDEPKKATGKTGGILKGGPSLYQVDPSGSYYPWKATAIGKHATSAKTFLEKRYTEGLELEDAIHIALLTLKETIEGEMNGDTIEIGIVGPPADHLLGYEGVEGSRGPRFRKLSKEEIEDYLTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF05</accession>
    <name>A0A317XF05_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Urease</fullName>
            <ecNumber evidence="2 9">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_506671</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="11">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472349.1">
        <property type="nucleotide sequence ID" value="XM_025609581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF05"/>
    <dbReference type="STRING" id="1450535.A0A317XF05"/>
    <dbReference type="GeneID" id="37111724"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000024">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029754">
        <property type="entry name" value="Urease_Ni-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01120">
        <property type="entry name" value="UREASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="14">
        <location>
            <begin position="401"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12 13">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="544"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="632"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="10">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY95588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="837" mass="90842" checksum="114C331D01F5D918" modified="2018-10-10" version="1">MHLIPKELDKLVISQLGFLAQRRLARGIRLNHAEATALISSNLQELIRDGQYSVADLMSIGKTMLGRRHVLPSVVSTLVELQVEGTFTTGTYLVTVHNPISSDDGDLEKALYGSFLPIPPADAFPDPDPADYEPEKMPGAILPVRNERITLNEGRKRIKLKVMSRGDRPIQVGSHYHFIETNPQLHFDRLRSYGYRLDIPAGTSVRFEPGDTKMVTLVEIGGNKIIRGGNCIASGKVDLARAEEIMLRLQVQNFAHVPEPTADSALVVTPFSMEREVYARMFGPTTGDLVRLGLTNLWVRVEKDYTSYGDECTFGGGKTIRDGMGQSSEQSTNDSLDTVVTNALIIDWTGIFKADIGIKDGIIVGIGKAGNPDIMDNVTPGMVIGSSTDVIAGENKIITAGGFDTHIHFICPQQVDEALASGITTFLGGGTGPSTGSNATTCTPGPVHMRQMIQACDRLPINVGITGKGNDCGGVSIEEQIYAGAAGLKLHEDWGSTPAAIDSCLDMCDKFDVQCMIHTDTLNESGFVEQTIESFKNRTIHTYHTEGAGGGHAPDIISVVEHPNVLPSSTNPTRPFTLNTLDEHLDMLMVCHHLSKNIAEDVAFAESRIRAETIAAEDVLHDLGAISMMSSDSQAMGRCGEVILRTWNTAHKNKEQRGPLPEDEGTGADNFRVKRYVSKYTINPAIAQGMSHMIGSIEVGKIADLVLWSPSSFGVKPAQVVKSGMIAVSKMGDPNASIPTVEPVIMRPQFGALVPFTSIMFVSQASLDAGVVQTYNLQKRIEAVKNCRNIGKADMKFNDIMPKMKVDPESYRVEADGVLCEAEPAGTLPLTQDYFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF09</accession>
    <name>A0A317XF09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_592027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473133.1">
        <property type="nucleotide sequence ID" value="XM_025616136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF09"/>
    <dbReference type="STRING" id="1450535.A0A317XF09"/>
    <dbReference type="GeneID" id="37118279"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="211" mass="24588" checksum="776850AD8645D047" modified="2018-10-10" version="1">MNPDSESEVYEQLELPDAESEDQHLIRTGFGEIPESKSRLHRRSLKVPIKLVSATITVLLALALLALVYTQWPPSPWKDCGNSPEEARRRGCNFDIMSFSWVLEPCDDTELTEEFLGLEDWQWFTEFNGTETVPKDVVGAGELDLWVSWKYHIIHCTYMWRKMHRAMERGRPMDSHLRSYNHTVHCSQMLLYNCVADMVTTRAYVRYPRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFN2</accession>
    <name>A0A317XFN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_580493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473423.1">
        <property type="nucleotide sequence ID" value="XM_025615331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFN2"/>
    <dbReference type="STRING" id="1450535.A0A317XFN2"/>
    <dbReference type="GeneID" id="37117474"/>
    <dbReference type="OrthoDB" id="2326446at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="54"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="176" mass="20446" checksum="0890BCC13AB907C5" modified="2018-10-10" version="1">MTTTKITQCHLTPINLHEQNQYTTLHHQRILCGWDSSISDLDGWKQKQVEGLKGFFWIMIPTEDKETLINAGHISLDAYTDPADPDLARSDKSLLTIQNFFILPEYQSRGLGRQVMEVVEGMARREPHGDAHCQAITLTSLSKRYWYEEKHIRDRFGPGGPPYCNQEWYERLGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGQ6</accession>
    <name>A0A317XGQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_580020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472911.1">
        <property type="nucleotide sequence ID" value="XM_025615299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGQ6"/>
    <dbReference type="GeneID" id="37117442"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="154" mass="17035" checksum="E06D95AC18628F20" modified="2018-10-10" version="1">MEMPRPPDEAGFDKIGCGRTTGADEPAGEADQDDRGPVGHQCLASHWWAAVSALSRAELIQTIIAIVIQSKALEDRPALVLSVRPTVGTEHAPLEWSLASRWCFVLISREYRSRSVFILLKEYNASPVKNLPRQLDRAASPASLHPTDCQYRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XH61</accession>
    <name>A0A317XH61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asteroid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_454102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473569.1">
        <property type="nucleotide sequence ID" value="XM_025607596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XH61"/>
    <dbReference type="STRING" id="1450535.A0A317XH61"/>
    <dbReference type="GeneID" id="37109739"/>
    <dbReference type="OrthoDB" id="5297549at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18675">
        <property type="entry name" value="PIN_SpAst1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039436">
        <property type="entry name" value="Asteroid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12813">
        <property type="entry name" value="XPG_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asteroid" evidence="2">
        <location>
            <begin position="161"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="627" mass="71378" checksum="68296573C276CFB9" modified="2018-10-10" version="1">MGIPFLTRHLYPFAESVVLGENQETPHSQVKSARAVVIDGPSLVYHVSMRLLSRSDHSLQYPDSQPTCDQISCGVMIYLLQLTILGVKIHNICFDGALPAQKRHTRFVRLEKSRRKLELLRSKPLCGFQRSGSPLNIRTINPEIVFQKRTLPAKYYNIPESPFIVPAVFEDLKYRWCRKNIASVVKDVPGLNVASLDDLPWADISVMVPGEADMYCAHLARLTGSAILTNDSDLLLHDLGTFGSVVLLDSVDLFSLPQGPQIRALRLCPALVAHRLGMPNLLPLAYEIKNHPDTGINQLIQRSKCIDESPEYMSGYHLFAEEYKSNPSFDQEVACQSYPQCFDPRVSELFSLYGVWSAQTFQGHPYMYLVVLNEDPTRQCAWVQGKIYRNMGYSALNISYPINERYTFIDEYVRRGGRITTDRISMGDKGWLLMEIQSLCCTLNTVHHHLGIAMASPVYWRMFALFIIYDGQTRLAVPSREHLLRFLTLGYMGKKLEWTDIHLLAQMQSVLYSLRILKQLLGFAGYTDEHTLQTRAILDTLPPLYILMRSIREMSEEFHTECSVSELVNRLLQLMEQTSYNADISTCGTDSHQYANDSAMSTAKINDFRPSLPRKNPSNIYELLSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XH62</accession>
    <name>A0A317XH62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_580278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473191.1">
        <property type="nucleotide sequence ID" value="XM_025615315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XH62"/>
    <dbReference type="STRING" id="1450535.A0A317XH62"/>
    <dbReference type="GeneID" id="37117458"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="94" mass="10690" checksum="B4637F9A830454FB" modified="2018-10-10" version="1">MVQRRSPRECLSEPYVDELPMRCQQLRKGFGECKRGLIDMRKRFRGNQPISVSKTESANSGPSQQLYAGKPAFETVKEISGDEVQMDPEKTRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UQ98</accession>
    <name>A0A317UQ98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_480617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000105">
        <property type="protein sequence ID" value="PWY63871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UQ98"/>
    <dbReference type="OrthoDB" id="4377744at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY63871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="55" mass="6607" checksum="7051D559153E63F6" modified="2018-10-10" version="1" fragment="single">RRKGPAGPVLAVRRTGQPDPRFNYELFNCNNFNIRYWSWNYRGCWHQTCPPIVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVE2</accession>
    <name>A0A317UVE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MAPEG family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_629312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000064">
        <property type="protein sequence ID" value="PWY65008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461359.1">
        <property type="nucleotide sequence ID" value="XM_025617548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVE2"/>
    <dbReference type="GeneID" id="37119691"/>
    <dbReference type="OrthoDB" id="2122304at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371">
        <property type="entry name" value="INNER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35371:SF2">
        <property type="entry name" value="MAPEG FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY65008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18235" checksum="7F457CB990F7B861" modified="2018-10-10" version="1">MSSILSTLGLQATPDQQVANHAVAYLIWNWFFAHGVLSTRPAKRLLRLDHNVAPRDDLTTYGEAAVQAGKITRRQLNRLKRQEAAHSNAMEGFPLFVAAILVALHTDLPNETINGIGAWYTLSRVAFGLAYVFIESEGWSFLRSVLWWSGNVSCITALVAGGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVK6</accession>
    <name>A0A317UVK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_374370</name>
        <name evidence="2" type="ORF">BO94DRAFT_480549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000078">
        <property type="protein sequence ID" value="PWY64493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFK01000078">
        <property type="protein sequence ID" value="PWY64502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVK6"/>
    <dbReference type="OrthoDB" id="4384442at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33626:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33626">
        <property type="entry name" value="ZGC:158463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY64493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY64502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="113" mass="12587" checksum="5662683018DADA94" modified="2018-10-10" version="1">MEVRGNNRSVMPLDVLGRTRATLTGPASTSPWPRGLGNLVKPCRAGDRALQLLLFNEECLVGTSHQLVPITSLPFVHTARRYYRLNGSVRPSDWLRRVGNDPPEPESWSNPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZ66</accession>
    <name>A0A317UZ66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-haloalkanoic acid dehalogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_479516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461689.1">
        <property type="nucleotide sequence ID" value="XM_025608747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZ66"/>
    <dbReference type="STRING" id="1450535.A0A317UZ66"/>
    <dbReference type="GeneID" id="37110890"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051540">
        <property type="entry name" value="S-2-haloacid_dehalogenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01493">
        <property type="entry name" value="HAD-SF-IA-v2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316:SF9">
        <property type="entry name" value="ACID DEHALOGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43316">
        <property type="entry name" value="HYDROLASE, HALOACID DELAHOGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="236" mass="26710" checksum="E767971ADA395E1C" modified="2018-10-10" version="1">MSQLSEYRLLSFDVYGTLVDWEGGILAAFQPTLDKTNAQFSREHLLTVYHKLEREQQEKTPDMPYSQLLATIHPMWAERLGLAAPTAAESLEFGESVGNWPAFPDTVDALKRLSQHYKLVVLSNVDRTSFAKTNAGSLQGFPFDLIITAQDIGSYKPDLRNFEYMLKTVKNTFGIEPAQVLQTAQSQFHDHHPARKVGLKSVWIERPGATMGNLAETIYDWRFDTLGEMADALERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V016</accession>
    <name>A0A317V016_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1715 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_332751</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461577.1">
        <property type="nucleotide sequence ID" value="XM_025606990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V016"/>
    <dbReference type="STRING" id="1450535.A0A317V016"/>
    <dbReference type="GeneID" id="37109133"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY66122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="198" mass="21547" checksum="70E482AD417362E8" modified="2018-10-10" version="1">MECNLLESLLDLEEDFYKEGYDLGVADGAQAGYTEGSVFAVEKGFEKFVELGRFYGKALVWAQRLADYQPSNNSDPAGLDKRVPSSSLASDKPDGSSLMDPAICQEMSRFSSNSRLAKNIDTLLELVDPASLPMVNTEEAVNDVDERMKGAAIKAKLIQRALGEREDNSDIHPDAKEPPTSGDGTGSIEDISSLNIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V422</accession>
    <name>A0A317V422_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_527557</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462339.1">
        <property type="nucleotide sequence ID" value="XM_025610391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V422"/>
    <dbReference type="STRING" id="1450535.A0A317V422"/>
    <dbReference type="GeneID" id="37112534"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF1">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY69024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="276" mass="29904" checksum="D646E0631B2A1BC7" modified="2018-10-10" version="1">MSMSTTDSATVREGFPRPFPNTPTNVLAQLRLSGKVVIITGAADGIGYAVAEAMAEANANIAMWYNSNDIAVEKAQTLAITHGVQTTAYKVDVSNPDVVQKAIQDVVKDFGKIDVFVANAGMAISKPILEQTLEEYRKQMSVNVDGVLYCAKYVGEVFQRQGFGNLIITSSMSGHIVNVPVDQPVYNASKAFVTHFGKSLAREWREFARVNIVSPGFFETKMGASPQAINEAYRMSALGRQGHVKEIKGLYLYLASDASTFMTGSDVLIDGGYVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4F7</accession>
    <name>A0A317V4F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_579315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462192.1">
        <property type="nucleotide sequence ID" value="XM_025615262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4F7"/>
    <dbReference type="GeneID" id="37117405"/>
    <dbReference type="OrthoDB" id="2279190at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="196" mass="21456" checksum="15FA276A5064D66F" modified="2018-10-10" version="1">MGDKSPEDITSEPPETPSIPTESLPSPATKPPKLCKRRKSRKHSNASIGTVDPPQEGQEEQKETPPEQTAPPAEETQPSEESPPKPPAEPEPTPQNDNKNTPQEKPQDPKPNMSTETTDDVTSLTKDVGEKAAPAKETIREITTGGMDMKIDDEDLNWKSSDKEGSLQIRIRLNLRAKVQLNLDARVKGEVVIGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6L5</accession>
    <name>A0A317V6L5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462155.1">
        <property type="nucleotide sequence ID" value="XM_025612855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6L5"/>
    <dbReference type="GeneID" id="37114998"/>
    <dbReference type="OrthoDB" id="4338083at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016414676" evidence="1">
        <location>
            <begin position="20"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="63" mass="6817" checksum="A1DD64E3A013687E" modified="2018-10-10" version="1" fragment="single">MHLSIPTLLLLPLIPGALTASLDILRPRKWDLRLFTPGCNPNTTSFELSVFHTQGVTVTAAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V868</accession>
    <name>A0A317V868_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_502946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462392.1">
        <property type="nucleotide sequence ID" value="XM_025609463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V868"/>
    <dbReference type="STRING" id="1450535.A0A317V868"/>
    <dbReference type="GeneID" id="37111606"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016195119" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="24"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY69187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="505" mass="56412" checksum="561A8446C6D9B02A" modified="2018-10-10" version="1">MRPFTALTALCGLFLSSTSLANAESTAPSSRVALPREFKAPQVFKNVNLVRNTNLEKGYLRETVNVVVENVDKQPQSDYYLSFPSNLYDKVGALEVRDKSAPEQGRFDVEATEFDSNSDFQYFVVHFPQPLAPSSQITLGISYSALNSLSPRPATINQNDRQYLAHSFSAYAPSAYTTVAQKTKLKFPSTNVPDYTTTDLTSGTDPERQGTSYTYGPYDTANVAPGTTYPISVRYEFTKPVLTASLLERDLEVSHWGGNLATEERYWLRNNGSQLTNNFNRVEWTLSTYQQLPSSAIRELKYPLKPGSVDPYFTDDIGNVSTSRYRPGKVPNREGSLELRPRYPIFGGWNYSFRIGWNNELSAFLRRAVTGADSYVLKVPFIEGPKVSEGIQYEKVVVRVVLPEGARNVHYELIEKASSNGLPSASQIESQLSSHKTFMDTLGRTALTLTVEDLTDEARDSQLVITYDYSLWDGLRKPVTITAGLFTVFVAAWAIGNIDVSIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8A1</accession>
    <name>A0A317V8A1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_539834</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462657.1">
        <property type="nucleotide sequence ID" value="XM_025612786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8A1"/>
    <dbReference type="STRING" id="1450535.A0A317V8A1"/>
    <dbReference type="GeneID" id="37114929"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY70366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="500" mass="54176" checksum="DBFA57E3E1DF1E7B" modified="2018-10-10" version="1">MTSKIAQNLKQPALDFLSFVNASPTPFHAVQSAKDLLAKAGFQEIKEKDSWSSTCRPGGKYYLTRNQSTIVAFAVGKKWKPGNPISMIGAHTDSPVLRVKPVSNKRGEGYVQVGVETYGGGIWHTWFDRDLGVAGRAMVRNGDGSIVQKLIKIDRPILRIPTLAIHLDRQETFAFNKETQLFPIAGLVAAELNRTGASDEAGDKAVTNGVNGEEKADFSPLKAITERHHPYLVELIATEAGVKPLDVLDFEMILFDTQKSNLGGLLEEFIFSPRLDNLNSSFCATVGLIDSVADASALDEEPAIRLIALFDHEEIGSRTAQGADSNILPSVIRRLSVLPSTAGGDSDIATAYEQTLSTSFLVSADMAHGVHPNYTAKYENDHRPQINKGPVIKINANARYATNSPGIVLLQEVARKASEDVGEGVPLQLFVVRNDSSCGSTIGPMLSAALGARTLDLGNPQLSMHSIRETGGTYDVAHSIRLFTGFFKHYANLSKTIFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VAJ1</accession>
    <name>A0A317VAJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_569526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462602.1">
        <property type="nucleotide sequence ID" value="XM_025614743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VAJ1"/>
    <dbReference type="STRING" id="1450535.A0A317VAJ1"/>
    <dbReference type="GeneID" id="37116886"/>
    <dbReference type="OrthoDB" id="5280464at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY70311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="374" mass="42934" checksum="1E03A8CEB959383E" modified="2018-10-10" version="1">MPSITSLPTECLWTCKHLHSIYVSNKYSVLGKIGPRDIPAFDDAVIAVRATRIVLESFDKCHFPPDPFPFDCLSLEAQTPSLDDIRLRENFRRAMYRSFLMGAVLCRAYQEPLSPLKEDDDRPQDFLKDAKLRIDDPDAWLITRDEMAYLLKYPSEHHSCEPALLSMYPEDATPRDLDLHHARVLYAEIVQCLLMTMAFLNPNANTQFFEDASHDTRELDRKVTIIPLGSFYPERISMPNNPHKAHKTLLVKQPVPHPQKTGTAWHPSSSCLWAILNNMHAFSGQPNTYGESYPTPPPPLQIFQYIFRTHMGLRFIDFAFEEDGIDSTHRLFVHHPSISRIFVDGWPEEVPIMFDTLGAEEGHYVTSYVPDPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCZ8</accession>
    <name>A0A317VCZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_267579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462772.1">
        <property type="nucleotide sequence ID" value="XM_025606535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCZ8"/>
    <dbReference type="GeneID" id="37108678"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="82" mass="9030" checksum="0EB0432E3F65368C" modified="2018-10-10" version="1">MGRQADWTPDLVQYLHPDPISPIANQNPSATVFPAAATPKVYNLQGRRRRAEMSSVDSHPTDIRNSGLPDITPEQQPLSPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VF66</accession>
    <name>A0A317VF66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_539552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462996.1">
        <property type="nucleotide sequence ID" value="XM_025612724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VF66"/>
    <dbReference type="GeneID" id="37114867"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY71598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13712" checksum="B64A5BF73D6753A5" modified="2018-10-10" version="1">MLDPLMVDDRRHGLSNQRYPELLLSVDPSLDVWDSFWVPRPIAVIGDSSTGLRARGGHSEADYHGPHPYSPNHREGRLWLSLSHCFRSPSHSLSSPEERRPAIRLAVSVHYYRMLAKPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFA0</accession>
    <name>A0A317VFA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_608352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463003.1">
        <property type="nucleotide sequence ID" value="XM_025616554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFA0"/>
    <dbReference type="STRING" id="1450535.A0A317VFA0"/>
    <dbReference type="GeneID" id="37118697"/>
    <dbReference type="OrthoDB" id="4646997at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY71767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="66" mass="7827" checksum="1C80D88EF4DF942F" modified="2018-10-10" version="1">MVRENLGWTTQHPYLALLKAKRAFRFMYTDKRTGRPMPRVSNKTLAQYLSKALVAWKTNRESLKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFG0</accession>
    <name>A0A317VFG0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_607606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463388.1">
        <property type="nucleotide sequence ID" value="XM_025616541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFG0"/>
    <dbReference type="STRING" id="1450535.A0A317VFG0"/>
    <dbReference type="GeneID" id="37118684"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY73123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="529" mass="59738" checksum="6AB32E40BEDC89EE" modified="2018-10-10" version="1">MPRVAPEDRKRVYYPKTRTGCLTCKSVPQRRIKCGEERPACLRCTSTGRQCDGYRDPASHPSPSNVSARPLLARPLSTYHSLACDQERRSFQFFLEKTVPQLAGDFECAFWGRLLLQSVHHEPVIRHATVALGSLHEHFNCDAAPFRLGTDSPHTSFALRQYLRAMRCLMPTPSHSQPLDIYLISCILFACFEAMRDYYGPAITHITSGLNILSEIRNPSSTSTPLCIGRTPYVPIDILCGLFTRLQGQVIVTVHRIGAARCNLWPELVINLDQPIVFQSLADARETLEIYTYYYRQRSTELLYQTHPTDTTTTINPAITLRDTSLILLSHWSTALDTFLQQHTTILTPRERRAASVLQLRKIDCFVALDILQAAGEAEAGHHVQWDKYCPFFEQMVALGESIIPPPSSATKKTFSLDLSIIAAIFNVAVRCRDPVIRRRAVSVLRASAIQEGVWNSVVVAAIADKWIEIEEEGLGEVRCCADVPDEARLADFMPVFDVERPRAEVYFSWGEEKGRARGRGVRREVFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGQ7</accession>
    <name>A0A317VGQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_240254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463380.1">
        <property type="nucleotide sequence ID" value="XM_025606367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGQ7"/>
    <dbReference type="GeneID" id="37108510"/>
    <dbReference type="OrthoDB" id="4158114at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY73115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16450" checksum="C41212184C78B860" modified="2018-10-10" version="1">MSSPHTARSILDAFYAAERIYMSAPPDQRDFSGVAATIAPSCRLEQTPALPYAGTYFGPEGMQSWGEQMADYFSVVDVQNPEIFERDGSNRIVVLSTIHLRVRKTGEDLYYPFCQAVTVDLQLGQITEMRPFYWDVAGVNEALQGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHN0</accession>
    <name>A0A317VHN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_475176</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463575.1">
        <property type="nucleotide sequence ID" value="XM_025608550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHN0"/>
    <dbReference type="STRING" id="1450535.A0A317VHN0"/>
    <dbReference type="GeneID" id="37110693"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001369">
        <property type="entry name" value="F-box domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000675">
        <property type="entry name" value="F-box domain protein (AFU_orthologue AFUA_2G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="173"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY73823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="730" mass="80918" checksum="2E98E4A7D4948F4A" modified="2018-10-10" version="1">MSTAYPDEIRASPEAASPVSPASSTGQIPLEQPPKLKGRHKLLQSLQRISSSPSLTRRGRSHSTGYRRDGKASLSCVSLSQSAYTPCLGNGSTSQLYGGLNARPITPGSSFPADHDGNARIRLVGSDSPNATHPRTVPLPTDLRPGSRGAMLGMDAVDEAATARSTPKPKRVFDFWGNMPDELKMRIFQYLTPKEIVRCSAVSKTWNKMCYDGQLWTEVDTTDYYREIPSDGLVKLITAGGPFVRDLNLRGCIQLKDKWQTEGDRITDLCRNLVNFSLEGCRIDRSSIHYFLLRNPRLQYINLSGLSSVSNSAMKIIAQSCPQLEILNVSWCTGIDTSGLKKIVKACEKLKDLRASEIRGFDDVDFAVNVYERNTLERLIMSRTELTDECLKALMHGVDPEMDLLEERPIVPPRRLKHLDIHQCPELTDDGVKSLAHNVPDLQGLQLSQCSELTDESVMAVIRTTPHLTHLDLEDMERLSNNTLIELAKSPCAARLEHLNISYCEAIGDIGTLQIMKNCPSLRSVEMDNTRVSDLTLMEASFRVRRRGYDENLPRIGLRLVVFDCANVTWAGVKEVLSSNAYLPRATRKSMQAVSVVTHTVDPSQSTTVIASSITPPPPPPVYPNEIIHLKCFYGWQMTVDEHNKRVLRGDLVAASRLDRKWAEYMMATEEAGAPGAGVRRRRRRAREAERIYNDDDEDAAYGVGVIPTLGAGRRRHTEGGGGTGGCSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VI70</accession>
    <name>A0A317VI70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_241654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463424.1">
        <property type="nucleotide sequence ID" value="XM_025606372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VI70"/>
    <dbReference type="GeneID" id="37108515"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16212" checksum="D9829E4BD38D83E9" modified="2018-10-10" version="1">MPQEGVKKKSPKKQARFGVNRRLTQTERCFATSRSRILGWGSIFSCPSKSYAQSQLQSVVRPVEFSLGRSKTTLSLISFFFFSLCLLSGFGSFLSLGDDRRRKEEHVHRGAARAKASRQVATISRPTRWKGSPRSAIQGVGQMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJR0</accession>
    <name>A0A317VJR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463766.1">
        <property type="nucleotide sequence ID" value="XM_025612552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJR0"/>
    <dbReference type="GeneID" id="37114695"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="65" mass="7375" checksum="3263066F3A2178EB" modified="2018-10-10" version="1">MQRGALAKESFILLGWKDWQVDWTGGMAAGSLLCFALFFFSSHRSKMKKKKKKKMMMIMAVGVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VK62</accession>
    <name>A0A317VK62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RAVE subunit 2/Rogdi</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_627561</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463621.1">
        <property type="nucleotide sequence ID" value="XM_025617431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VK62"/>
    <dbReference type="STRING" id="1450535.A0A317VK62"/>
    <dbReference type="GeneID" id="37119574"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028241">
        <property type="entry name" value="RAVE2/Rogdi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618">
        <property type="entry name" value="LEUCINE ZIPPER CONTAINING TRANSCRIPTION FACTOR LZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13618:SF1">
        <property type="entry name" value="PROTEIN ROGDI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10259">
        <property type="entry name" value="Rogdi_lz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY73869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="34725" checksum="11162928EAF55996" modified="2018-10-10" version="1">MATWAYPPLPQERLEQEVDSALANELEWLLRSLQDSLASLREGLHECEALLAPKEPGSTLVLSSLRSENVKGYVTRVGTKIVKGDIQLRLSSLASRGSATTRLCLSNAPATPELVLSQLVTVKNLVNQSLDIVDVSTWTGDPLNASFIFSQLHLLRETISEARQMLKGENDKVRGKWWETSAQEEMFDPPLPPYLSFHLSIADSALVLHLRTLESNTPTHTPTAFAADISLTGFNLRDRLFGTRHRPHDEAGDVFTWKGDEVKVKEKIRVESQDPSLMAVMAKLSALEHEVMKWISALKVLMGNEDTDSESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKQ6</accession>
    <name>A0A317VKQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_232481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463509.1">
        <property type="nucleotide sequence ID" value="XM_025606309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKQ6"/>
    <dbReference type="GeneID" id="37108452"/>
    <dbReference type="OrthoDB" id="4422094at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="395" mass="46115" checksum="EA7ECF9CCAA02CC8" modified="2018-10-10" version="1">MPPQRRNPCHRYGLRSKGPVDREVFQVLDTLKAVRPSKVRPVKRPKAIIHRFTTRIKLNFVTLRNELLIREEDSTDSSSTSDPDSACDSEMEVNETKTFTTREYPRNCRRLNMPIRWLAVNVATQEKVPLDAIFDAKYMPLDDDAEFQDRVGQWQDLDAWMDGFMFDSLTSLFNLSSSDNEISFQEDCYLPLIKASLGKCDDGIFFRHCIRRQGFNDTSGRQCFGFPLAVCVYKYRLGQRGIAQSEITPLLLQVNLGYEYNSHREQYPAYILSQRGRNFRFVKATMTRQEVERLRDKETLSGKIQVQRTRAFNIRDRSGRREFVRTMIGLLRSFEDRPEAEYPMYTSQWFFREKEKEGGGERGEGEGEEEGGEEGERGGERRGYLYRIIASLWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKT7</accession>
    <name>A0A317VKT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable lysosomal cobalamin transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_608073</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family. LMBRD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463314.1">
        <property type="nucleotide sequence ID" value="XM_025616551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKT7"/>
    <dbReference type="STRING" id="1450535.A0A317VKT7"/>
    <dbReference type="GeneID" id="37118694"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072665">
        <property type="term" value="P:protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050854">
        <property type="entry name" value="LMBD1_LysCbl_Transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130:SF2">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORT ESCORT PROTEIN LMBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16130">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="374"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY72540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="562" mass="63255" checksum="E768F5C7E669958F" modified="2018-10-10" version="1">MAPLQTSLIWAVYAIVVAVLVTIASVFIYTYQTPRDRSSAVTFTCIIAITSLLATVLLLPVDVALISSTTFPALGQRKAWATQEEVDKIVSLLTVVYYLLYSLDAFLCLLAIPFVYFWYEEYDEAAIEAGEQSAPKRLWAAFKYTLSFIAIVIVLFIVGFLVPVPTAKDSKDPGYLRKLLAENRGERVLTFTLGLLITLGLFLYVLYTSTGLALLPMRMIRVAPSISDWKATTAAQLESNQERQRQLEGRCRGDPGLLSSNERRELDTLIRDERTLIRRQRLAQETHGEVKSRLMRTWLVVTAFFRPFKLLGGIALLLIALMIWISMLLTAIDKANNSLCKQRCGYVLGHISGFNPLNWAFVQSAKVFPVDYVIFAILVLLLFGSSVVGISTIGIRFLWVRIFRIRQGHTSPQALLLTTAMLILAILALDYSIPMFIAPQYATFGPQTFCDRSPSPLGKQLDCLNNRHLVKPCSDSTNNVAAKQVCTSSVTSRFLNRVTISYPFFGMVFFWSQFVFLVIYLLIFITSLVRHPKLDQRLLDQEAEEAEEERLLANSGRYVDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLW5</accession>
    <name>A0A317VLW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_524869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463614.1">
        <property type="nucleotide sequence ID" value="XM_025610289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLW5"/>
    <dbReference type="STRING" id="1450535.A0A317VLW5"/>
    <dbReference type="GeneID" id="37112432"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY73862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="197" mass="22417" checksum="C6F877DF76784AB0" modified="2018-10-10" version="1">MADKKPSSVAAPTNPRGIPAAPFVDNVADYVSSREEVEPTLRSFQEMISKYQFMEVNTQRRGAGLRDKIPDIKKTLEMVRFLNMRRENNSDPLETNFELNDTLYARASVSPADTEEVYLWLGANVMLAYPIEEAETMLQDKLSAAEKSLSNCEEDLEFLREQITTLEVATARVYNWDVVQRRKEKAEGKGEEEDKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VP32</accession>
    <name>A0A317VP32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_538509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464131.1">
        <property type="nucleotide sequence ID" value="XM_025612505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VP32"/>
    <dbReference type="STRING" id="1450535.A0A317VP32"/>
    <dbReference type="GeneID" id="37114648"/>
    <dbReference type="OrthoDB" id="5207033at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY76134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="348" mass="40511" checksum="341F8092AF3F8906" modified="2018-10-10" version="1">MLPRRSKSIVNEASFAKPGSLNSQQFRPLFPEAFWPVICTDINGSFFCDDVLDENDNLVKHVSWSCFKIKFVDDPHLYQWVQPAIFMTWYPDALKQVVFIIDHPLPPSELLQVLPTKQATGNPYVWHAIFAGTMMGLYDKSFWGLRNLVRKTEKARDNPNDLHPEFFPHLHDIARHVFHSNETLDIAEHTLQSLVNEYVRSRELYSSIPKGEWLQNERQLLFRAKQLHSLKTRSRSLAERLHNEINLGFNLVSQRFGSDAKSDNAMMKTVAIVSMVYLPGTFVSGLFGTNFFNYSDGKEVMTESFWIYWVITIPLTLLTMLIWACWHYYPRKKSNLDPNSKRTETFEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPV4</accession>
    <name>A0A317VPV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polynucleotide kinase 3'-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464206.1">
        <property type="nucleotide sequence ID" value="XM_025612456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPV4"/>
    <dbReference type="STRING" id="1450535.A0A317VPV4"/>
    <dbReference type="GeneID" id="37114599"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002548">
        <property type="entry name" value="DNA kinase/phosphatase Pnk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="436" mass="49021" checksum="7422F0C607F78356" modified="2018-10-10" version="1">MAGAGGTKRTASPTRAISPPPLKRKIESTVTKKAVSSFFTPVSQKKPEQITWRVINNSAVIGKYISEPGHKQRTEKPRIAAFDLDSTLVSTASGNTFPRNSSDWKWWHATVPSKLKELNENGYYVVVVTNQKKISLKKDLKGGQSDSKSLTNFKERVMAVMMQLDIPLSVYAATEDDGYRKPRTGLWNEMLDDYDFDVAGVNLPGSIFVGDAAGRPNDHSHVDRGFSINIKVPFKTPEEFFLNAEPEPTVEPFDPSMYLQAESSDDVTPPFSRQSPLELVVFSGSPGAGKSSFYWDYLEPLKYERVNQDLLKTRPKCIKVAKEHLAAGRSVVVDNTNADPETRAHWVEVAKEFHVPIRCIYFTASPALCRHNNAVRAANQTLNPESRTLLPGIAFGDFLRRFKEPSIDEGFKDIIRVEFQFRGDQEAKRLWGQYWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPX0</accession>
    <name>A0A317VPX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF647 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_473439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464209.1">
        <property type="nucleotide sequence ID" value="XM_025608476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPX0"/>
    <dbReference type="GeneID" id="37110619"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006968">
        <property type="entry name" value="RUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770:SF31">
        <property type="entry name" value="RUS FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12770">
        <property type="entry name" value="RUS1 FAMILY PROTEIN C16ORF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="7">
        <location>
            <begin position="64"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY76396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="506" mass="54956" checksum="24BFA4C0D98CDEEF" modified="2018-10-10" version="1">MALNRDSAAITLTEVDEVNHPTATYIYSEPAAGPAHLTHEKKHGERWGRVDVAHAPSSASASWSSKALLDFLVDVFLPAGYPHSVTDDYAPYQFFDSLQAFSSSIAGLLSSRAVLQGVGVGNADASPTSALLLHILQDTSGRIATILFAHRVGTALEPECKMYRLAADVFNDLAMILDCLSPMIPAGAPRVIILSTAGVLRALCGVAGGSSKASLSAHFSRWGNLAEVNAKDSSQETIISLIGMLVGSLVVSRVTSFAATWISLLMLLALHLSLNYAAVRSVQMTSLNRQRANIVLSTILNSDSELTHLTHPEPTEQYSPSPWKTLTPAQVASQEKIFETDGILRWFLTTKTTPTPSSQTLGYCRIGISLQQFIASSSFSISTSTESLQTPIPMPHLISLFSEEHYILYLTNRKLRTWHANILLKNTSTAQSQLKAWAHALVAARDLSKSSSDEFDVEGIINVLERTLDFLNDDGRFGRYVTALTEKGWDLSVAALETRSGRRIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPY0</accession>
    <name>A0A317VPY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar membrane PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_568363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464237.1">
        <property type="nucleotide sequence ID" value="XM_025614672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPY0"/>
    <dbReference type="STRING" id="1450535.A0A317VPY0"/>
    <dbReference type="GeneID" id="37116815"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY76424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="314" mass="33973" checksum="127F91CEB48DE7E6" modified="2018-10-10" version="1">MSTLWSAASSNADTVPLTTREAASGLLGSISLTCWIFLLVPQLIENYRNGNAEAISLLFLFVWFIGDITNLIGGAWAGLVPVIVAIAVYFCIADGVLIGQCLYYKARNARRSSSGTISRRRSSVADAPDPTTPLLGRRFSDVGRRAGADADADEDDMLAKIVEENDVGRKAWVRNFSSVLGICVIGMAGWTMAWRTGVWKPAPVEEVDGGVDMAPGAMVLGYISAVCYLGARLPQIYKNYCDKSCEGLSLLFFILSLLGNLTYGAGIICHSTEKNYIVTNVPWLIGSLGTMVEDVTIFVQFRLYATRDTVTPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQM1</accession>
    <name>A0A317VQM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_210104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463835.1">
        <property type="nucleotide sequence ID" value="XM_025606152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQM1"/>
    <dbReference type="STRING" id="1450535.A0A317VQM1"/>
    <dbReference type="GeneID" id="37108295"/>
    <dbReference type="OrthoDB" id="10018600at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016430752" evidence="1">
        <location>
            <begin position="19"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY75208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="451" mass="47267" checksum="92E281638F425061" modified="2018-10-10" version="1">MLPLLLFLSAFGAATVTIHDPGDFADLVAGAADDALTADWDYTPTTYQVDAITGAYEYSSTTENLSHEIIAVSANDTSVLVITESSEVNVSYSTIIKHGYSSDLYQASFFGSNAAINVANESVAYFDHVNVTVHNGAAKVYSYGNNTYVSISDSTLYSSGPVSHGLYAAGYGTVVGRNLEHYSGAYRSSSFAGDSPRGYVYVYDSVAHTAGIGSAIIYGQGTVYAENIIGYAEKAPIAFLDTAQIDIHDSDLTAGLLAGAVIFSSGTRGSGSEINFTNTRLTVLPDTAAALWFGNVIASSHIASTTINTTSGILVIANHSQVTQDFSYFADSTAAAEATITVSESDMTGDLVAYNGSSISWSLTEYSSLTGTAYSGYGTSFFAVSLDATSTWILTNDTVVNNLMDSDTTLSNVNSAGYPLYYDSSASSNGWLNGTTKKITGGGYVKPATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTC5</accession>
    <name>A0A317VTC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_538032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464362.1">
        <property type="nucleotide sequence ID" value="XM_025612399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTC5"/>
    <dbReference type="STRING" id="1450535.A0A317VTC5"/>
    <dbReference type="GeneID" id="37114542"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03440">
        <property type="entry name" value="hot_dog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF3">
        <property type="entry name" value="THIOESTERASE-LIKE SUPERFAMILY-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="161"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY77175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="34835" checksum="ADDB075D01CE59EB" modified="2018-10-10" version="1">MTERSYLDPLALIKYPTVPHGGYTTSIIYRLVLVHFAQTHPTLYNEPATPISMQLAFLRRTATGPAVLMIQDTKLGKRTSTVHVTLLQPLERKKPTPPSPGEEELEVKVAGYITVSPAHAEVGFSAVTGWNLSPPPPRGSKPDGAVDLLALAATGRDGAWKRLNAPFLSFRRATKQTEFFGPELGSAPGRMVAEQWARFRPEGDVTARWTNEALVYLTDMFPTALAGFDEAAAEASGRRGQAQHWYPTVTLNIDLKRRLPAEGVEWLYSRVHSKLVQDGRTDLDVTLVNERGEVVALSTQVGLVVSASRNLGTRQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VU10</accession>
    <name>A0A317VU10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="14">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_605127</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="14"/>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464330.1">
        <property type="nucleotide sequence ID" value="XM_025616469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VU10"/>
    <dbReference type="STRING" id="1450535.A0A317VU10"/>
    <dbReference type="GeneID" id="37118612"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016281446" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY76517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="431" mass="46645" checksum="A05E47456457DAD8" modified="2018-10-10" version="1">MQLLASLSILLGLLAVSHAGNVEKNNNVCTVKANGGQQDDVPNLLEAFEQCGNGGTIIFPEDQTYWIATRLHPTLNDVAIEWRGKWTFSDNLTYWRNNSYPVAFQNHHAGFIISGHNISVNGYGTGGIDGNGNAWYNAEKGDTQPGRPMPFVWWNVSEVVVDSFYVKDPPLWSVNIMNGTNMRFNNIYCNATAVNAPWGDNWVQNTDGFGRASIILHTDTMDAVNIQLTNFVYQGGDDCIAIKPRSYNIDIQNVTCVGGNGIAIGSLGQYLEDSSVANIRVDKVKIVRYNEDMHNSAYLKTWVGALVPQSSYESGGVPRGNGWGSIRNVLFSNFDVHGANAGPSISQDSGDNGSYAGTSKMSISNVAFVNFTGWVDTSKSVVSTVSCSEVHPCYNIDFDNVVLYPGKNATTPGTGSCKYTADGGVHGLSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWP2</accession>
    <name>A0A317VWP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="3 16">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO94DRAFT_588666</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. Binds RNAs which might negatively affect its histone methyltransferase activity. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. COMPASS recognizes ubiquitinated H2B on one face of the nucleosome which stimulates the methylation of H3 on the opposing face.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the COMPASS (Set1C) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Set1C/COMPASS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="3 16"/>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464153.1">
        <property type="nucleotide sequence ID" value="XM_025615898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWP2"/>
    <dbReference type="STRING" id="1450535.A0A317VWP2"/>
    <dbReference type="GeneID" id="37118041"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20072">
        <property type="entry name" value="SET_SET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017111">
        <property type="entry name" value="Set1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024636">
        <property type="entry name" value="SET_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11767">
        <property type="entry name" value="SET_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037104">
        <property type="entry name" value="Histone_H3-K4_mtfrase_Set1_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51572">
        <property type="entry name" value="SAM_MT43_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 16 20" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 16 20" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="1097"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="1223"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="139"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="509"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="598"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="676"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="509"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="608"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="622"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="688"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="746"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="786"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PWY76340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1239" mass="139192" checksum="05CD8808CD1B7D73" modified="2018-10-10" version="1">MSRSSAGFADFFPTAPSVLQKKRKSTRERHRSGAHTDRENSDEGPTLLSEPKAIHDSTPRLYAEDGKIASAVNGDGPSSSASVSVSASRSSTHNQSTAYGNEAHLDTLTPLTNAESSPTQKLSPSHARAINGINESSRISKTEEIKPAMTPLQTPPTPRSQSRPAGNVRGWKLTYDPDSEKRMSSKEKRRKARYADIVSNGQDDRPADPRLKIPNYSRGAGCKQKTKYRPAPYSLKHWGYDASTTIGPGPPVQIVVTGFDPLTPIAPINALFSSFGDIAEINNRTDPITGRFLGVCSVKYKDSASFRGGGPVLAASAARRAYYECKKEQRIGTRRIRVELDRDGIVSEKIVIRTIDSQRMGDKNNFLVAEELKADIPTKNNEPPPTAPKGPSGRSLLRPAATVPEGPRASFLRPAAPSLVEEIPILSQIKRDPYIFIAHCYVPVLSTTVPHLKKRLKLFDWKDIRCDKTGYYIVFENSRRGEEETERCYKMCHMKPLFTYIMNMESQPYGNPNYERSPSPQRLQAEQRERAEKNRLKREAELDVEEEKRQRAIDLDPCKEVMAIIIRDLRDKLLEDVKSRIAAPALYDYLDPDRHATKRKKLGIPDPEGAKRPMFRIDVDSSAGTPDSRSDLSTGRNPLSSSGLNILALPRIRKAHRLDRTNTAFLDERRKQPLRRKEVRPLYHRLQQLHDVDDSDDEQRTPFTRDTEDLDSRAPSRLSSETSDSEEDVDTFTSETLDLSVAGRQIDSDRSRDIENSKNDISPGSPNEAQQHVTRDLSPLSRKRKRDDERARARKRQKEDVGFFDGDDAGPEENQVVRRSSPGPGSILDDVSAADDPSVTITDPAGSQCHILVDGQKDDAVALMRSWSSNVEFEGIGKDHRHLISSVGNFEHGKQRDGPRTEIEWRVSNDEPRSTVEDDESIVLDLDGWQNLIKDEEDLCFLRDVLGEVSRSNVGNLSAWAWRQKEIKALNRPEESGPVHEETSIPGYYVSNITGAARTEGRKRILESEKSKYLPHRIKVQRAREEREARAKSDPHAVAAEAARIAAAKTISKSTSRSTRVNNRRLIADINAQKQALPTPSGDGDVLRFNQLKKRKKPVRFARSAIHNWGLYAEENISANDMIIEYVGEKVRQQVADMRERRYLKSGIGSSYLFRIDENTVIDATKRGGIARFINHSCTPNCTAKIIKVDGSKRIVIYALRDIERDEELTYDYKFEREWDSDDRIPCLCGSTGCKGFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYI5</accession>
    <name>A0A317VYI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_626333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464996.1">
        <property type="nucleotide sequence ID" value="XM_025617351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYI5"/>
    <dbReference type="STRING" id="1450535.A0A317VYI5"/>
    <dbReference type="GeneID" id="37119494"/>
    <dbReference type="OrthoDB" id="10011777at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40624:SF1">
        <property type="entry name" value="BIOSYNTHESIS MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12025)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY79424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="108" mass="11931" checksum="AC765A4230B6A29C" modified="2018-10-10" version="1">MASSEVNIVALVYPQPDKVEELSALLANLTQQVQANEPDTLVYYSFTNKEKTVISVIERYRDQAAFEKHGQSAYFKEFVEKGKGLMAKPFELVVGGGVLEGSTSVVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W285</accession>
    <name>A0A317W285_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_166239</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464954.1">
        <property type="nucleotide sequence ID" value="XM_025605905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W285"/>
    <dbReference type="GeneID" id="37108048"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY79382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="205" mass="23229" checksum="1CEDD8A5B4CE2766" modified="2018-10-10" version="1">MRVGYVVLFCFTSVRSSSSSSILYKSCIQMWNLLSILLAFSYFEHYGPSHCWSALGRNIECIVSCRVPWIRLDFGCPSRRMIIIPFVGSRNAYTAILSQIIPTSDDLLRTAQYLNRGGYIAGRSRPLYDNETRLDPLAALVFCSIFPIGYNPPIATSSIAIHHLPGFSPFHHLRQASRPYQQHPRPSPDPGKFETTRLPGLMFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4Z4</accession>
    <name>A0A317W4Z4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_558064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465702.1">
        <property type="nucleotide sequence ID" value="XM_025613979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4Z4"/>
    <dbReference type="STRING" id="1450535.A0A317W4Z4"/>
    <dbReference type="GeneID" id="37116122"/>
    <dbReference type="OrthoDB" id="406765at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053191">
        <property type="entry name" value="DcsG_Biosynth_Enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39217">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39217:SF1">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY81634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35624" checksum="9CD04E10F784D563" modified="2018-10-10" version="1">MRPVIETPRILFLTTQQPHTIRAEWPYYQNYDLPLLLKDKGALVAVKSWMDEDILTALNQYDTVTFLWCNEYYKHPKAFFAFLDKVDKLVKTSPYTPHVAPPRIINDTKLEGFVIPKTRLVDPQRYTVAELQQLVQNFHPSGSVVLKPSMSASSTLTRRIADTSALSADDMTFLGLCTGGGLQSSLLIQEFESAISTGEYSFVFVGPHLTHVMVKSPQRGDFRVQDEYGGSAKLTDLLGIKLETIQVVQAVFESLQRRFTSKDAEEIGCGEIGYVRIDGLITDDRPFVLMEIEAIEPHLWLETGKGVSRMLSLLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W502</accession>
    <name>A0A317W502_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_536928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465774.1">
        <property type="nucleotide sequence ID" value="XM_025612151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W502"/>
    <dbReference type="GeneID" id="37114294"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY81706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="364" mass="42466" checksum="D7E50B3FE06B4862" modified="2018-10-10" version="1">MTFFNKPTQAPNPPNPQTKWKLYQKKLKSLRTTLFHRTPPKPNPIDRSPFPFLRLPPEIRTQIYHLLLTVPDDGALWLRYSLPRQKWWDATPFCQSPGPRTPRPRVTLGLLLTCHTIREEALPILFRINKVWLDAPPGKCLEFLTSLPPTVSGGIREMKLWIDAYLNCGRATGNLPSFSPEVKEEHRLRVEDELLTPWGELFSWMQGNLRMLKTLHVWFGPGRSWHAGNLGAISLEWQGFYRRGWLEKIWEMRQVEWVLIEAQLEWCEQMEERDRESLRDLMGDVQLVKGFEEVSLEWSHFFFLSSACEQFPETSLCISLRRGEGLGLGELPEYKPIYTLNDMICPRICGFAEPQPPRSPNNCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W817</accession>
    <name>A0A317W817_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DIL and ankyrin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_471173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465149.1">
        <property type="nucleotide sequence ID" value="XM_025608369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W817"/>
    <dbReference type="STRING" id="1450535.A0A317W817"/>
    <dbReference type="GeneID" id="37110512"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="232"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="425"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="734"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="754"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY80290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="851" mass="95344" checksum="BC3E2FC837B483BC" modified="2018-10-10" version="1">MDASGSPRGASDELDRSDPELPDRSARKSMHAGLPDDLPKSLDDRRSVPVIQPEMEMYDAWQGQSQFLTTPVAAKPLSFSLALDDHSHDEEHNLQAHYGRGLAAAADDDNESTTTARLEDSDARLMEMLAAQAAHREVDSLGANEEAIATDEKLSDPEKKDILQRSLNMAASNGDVERVRKLLQGKAREYVDVNMPDEEGTVPLIYASCFGHQDVVSALLDAGAHIDQQDRNQWSALMWAMTNRHKTIAKILLDHGASPDIKSSSGGTAFDFAQPGSEISEYLHENGYHFGPSAIEDDFYDSGFGHGRFEEEIAENEMKRRMMMEESAINLEVDLSSLGLDEKFDSLDEDELEEEQQEFVWDRCLNDQMFVFQESELERILNIIITNMTPQRSPSQKPVPANLLFLSARYAHYHASPELLAKLLVSATDKINDVVERHQWDMTILAFWMSNATLLLHYLKKDGGLVEATVEFQLHLAELINEIFILIIRDAERRMNKVLDAAMLDHETIPGLEDVHFQNEWKLFRSKSKAKAPEPAEKRFRPPSPRRRAQVSPRNITSLLSSTLFVLDLYDVHSVITTQIISQLLYWLGAETFNRIMSTKRYLARTKAMQIRMNVSTLEDWARNNNRQPEHYENGSTSSTGESTMEAARRHLAPVIQLLQWLQCFSSLGDDFESLVTTLLQLQQLTPAQLLHAVKSYRPEVGEKGLTKPAMKFLIDLQRDPELLFREQAKLQAAKQKATAQEAGPTDGRPQTPPASIASEAAASPEASTRASVASPGSSVTSPRPGPSAWMDERSNNVFLDPSLTLPFSLPTSTDMLISYGAGWGGTNRERARKYIPTVPPEVLSRFDRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBJ5</accession>
    <name>A0A317WBJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_536510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466344.1">
        <property type="nucleotide sequence ID" value="XM_025612033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBJ5"/>
    <dbReference type="STRING" id="1450535.A0A317WBJ5"/>
    <dbReference type="GeneID" id="37114176"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000033">
        <property type="entry name" value="MBL fold metallo-hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="3">
        <location>
            <begin position="113"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY83876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="414" mass="46247" checksum="D407516376684A8B" modified="2018-10-10" version="1">MFVCPRTGGKLPPSISSLVQLPAATSPSYPRQVATLQRHYRALSNQARCQGAINHPKCSAKTLTPSNASTPRIPHRPISSSTPTNGPNQEVWRVESTSPTEPTIDAIFETNTGTWQYLISDPATSSAVIIDPVLDFDRTTQTVSTRSADSLLRMVRDRGYKIEMILETHVHADHLTSAAYLQQHLAQSQGFKPPIGIGKRIEKVQTLFGHRYAVPMGEYTAVFDKLFDDDETFKIGNLTAMAVHLPGHTPDHLGYRIGGMYSLPHPFITHIILLVNDIENIFCGDSIFHADIGTARCDFPGGSARDLFRSGRKLLSFPGHFKIWTGHDYPPADREQPRPWMSVQEHRQQNKHLKDGTTEEQYVSLREARDAQMQAPKLLHQSLQINIRAGQLPTPTEAGHRMVHVPMKFEGGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WC76</accession>
    <name>A0A317WC76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_519434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466297.1">
        <property type="nucleotide sequence ID" value="XM_025610070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WC76"/>
    <dbReference type="STRING" id="1450535.A0A317WC76"/>
    <dbReference type="GeneID" id="37112213"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="346" mass="37554" checksum="C8A484436303911B" modified="2018-10-10" version="1">MSIPQTYRAFRRSADGSSLELVQEELPSLLHPEQVLIRIHAVSLNYRDIAMMTGNYAAVKDKGIPASDCAAEVIAMGSNVLTFNVGDRVAPIFDLSNVTGTEEEAAMRLGGDVDGVLREFAVFDQRELVRLPDHLSWEEAACITCAGTTAWTALNMPRTNGTALLQGTGGVSMFAILICLAAGIHPIIMSSSDDKLSIVCSLGKAGAVDTINYRIHPQWDQEVLRLTNGRGVDVVIENVGQTTLSRSLSSLAKRGTVSLVGFLGGHSVDQYPNTMTPLLAKQATMRGHIVGSKIDQQNLCDFLTEKNIRLDPIIDKTSFSFEESQAAFDYLYAAKHMGKIVIKISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDI7</accession>
    <name>A0A317WDI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_557356</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466461.1">
        <property type="nucleotide sequence ID" value="XM_025613922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDI7"/>
    <dbReference type="STRING" id="1450535.A0A317WDI7"/>
    <dbReference type="GeneID" id="37116065"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY84536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="527" mass="58750" checksum="9DBEE42C2CDC0210" modified="2018-10-10" version="1">MPRVGPACLTCRQKCRKCDRARPDCQRCRSKGLVCGGYPEQFRFCGIASRGKWKGARIPVSSRSSTRTRTGISDAAPETHTSPTQEVTVTACFPSKGDQAPAAITLGSSKSPAQEAPVPGSFHEKHSRPLPELPDDITTLLNSPDTAKLLGHYDEIICPHQIAEVGDDPENPYRAYILPLARKKIGLLYAVLGLAASHLGRMIGDEFLHEATAVEYRMKAIRALSEEIRKSQRTSLLEDEQDTVLAIIQVLLLHDISESGVSSHGIHITGAMSVCKQLLIAEGLHRRRQRAMFFLGNLAWLDIIRAFAGSERMCFSQDIRELVAFASDKKFELVNGCPREVFLVIGGALEKAKEYTLGWLTWDEYQIALLLARHKLYSWNPQGRDYPSPDPLWLAIAEAHQFASILRILWLLDPSKPASSPDIQECVKRILDATALISPDCSLLELLVLPVFMAGADCLSRHSQYYVLTRLHEIERRSEFRNPVPADLLRKVWDARAAQAPDDSANISWTTFTHCPGLARQHDYLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDP3</accession>
    <name>A0A317WDP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_586900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466319.1">
        <property type="nucleotide sequence ID" value="XM_025615788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDP3"/>
    <dbReference type="GeneID" id="37117931"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="106" mass="11838" checksum="90C0129E71C47BC6" modified="2018-10-10" version="1">MHLNTDQKWTLATIAGSLVGIILLALAGLVIYNAMLSLLLKYRNPHIKPFKPNSPEEMRAALEMVRPSGQDAAEAGLSRMVRKLSMIQRVKRLMGWNKGDTDEYAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEL4</accession>
    <name>A0A317WEL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_536024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466390.1">
        <property type="nucleotide sequence ID" value="XM_025611920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEL4"/>
    <dbReference type="STRING" id="1450535.A0A317WEL4"/>
    <dbReference type="GeneID" id="37114063"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="243"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="715"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="941"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="747"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="803"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY84465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1055" mass="114977" checksum="63620795C8BA3633" modified="2018-10-10" version="1">MASAPSPAHADNANEDDPSAASDSFFYAHEDHDASSGHDPLEKDDGLADTKPAKDPLPMQKRRRVTRACDECRRKKIKCDGKQPCTHCTVYSYECTYDQPSNRRRNPAPQYVEALENRLHKAEALLRVVLPDLNLDDPQFDVHATEQMLAAIKREKQQQQQQQQQQTAAASLPATNDRRRSSVAIAGPADPSADGNGGDESLLESMVDNSGYLDLDDQGHWDYHGHSSGMTFIRRLRKQLGASDIQPPSIRSRPVSQSKFDSPKSVSESPQDASLPPTHDLPPRDVARRLCHNAFDDGCSLMRFVHEPSFYAMFDRIYDTPPDQFTNEENSFLPLLYIVIAVGCLFSDGGMGALDVSGYEGAIGQGFQYFKAGQQLLEITDCRDLISLQAICFMVLFLQASAKLSTCYSYVGIALRSSLRLGLHRKVTAHFTPLEQELRKRIFWVVRKMDVYVSTMLGLPLILSDDDIDQEYPASVDSEFITKDGILPMPADHIPLMAGANAHTRLSSIILKVVKYIYPVKHAQHRAGSDQRYVVSHSKIREIERDLQAWMEELPAALRPGTEVSPQLERIRQLLRISYAHVQVMLYRPFLHYVSSGSQARGVDRRSYACAAACVSVSRNIVHITTGMHKRGLLNGSFWFTMYTTYFAILSLLFFVLENPDSPTAKDGVLKDAMEGKTTLAGLAKKSMAADRCSQSLICLFKNLPELLKNRQSATATRANLKRPAPSGGGRSTAAKIPATGMPPPQRASTFPNQLLHRSTKSETSNTLKSLDDSATSRNATTNLRHSQPPTWFPSTPEPPADTVSTPSETATTNASARASPVSASLPAGDSSAASTFNAQAFANTCNFPDLMPIMFPSDDPFAYPTQPMSTLENDHFQDATGAPVTGQFAPGMVSTADTNGLSALAASTPTVDGFGNFPLFAGGTRSGLGPSISNRLANQQQMNTSRLQSPGSHASTPGTNGEVVNSPDLVSLPNQNFMWQGYNFQPPNFTAEAAVPATASNLGQFGLGMDDSNPGGLGMGLDLGLPLDDIFGNGDACRPGALGDDWTQWMNVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEV8</accession>
    <name>A0A317WEV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_586819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466235.1">
        <property type="nucleotide sequence ID" value="XM_025615780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEV8"/>
    <dbReference type="STRING" id="1450535.A0A317WEV8"/>
    <dbReference type="GeneID" id="37117923"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="119"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="477" mass="53470" checksum="7CADE70210E560C9" modified="2018-10-10" version="1">MKACTGEELHLDRYHNAQVPWWQHPPPADPTLQGVSPSNLNLPEPAFLSEELKHYQSSTFGLFFPVLDSFLLESTVKAAYYQESSAASPGISSAKACIFAFLALAPTVVHGSKLDHLKSSLEYACEAYRLLPEVLKEPVSLDGLQPLLLLCLCSQGLTGDSLTIDHLLSTASRFIYHFKANISPRIVWEHPTALDYHARHLFWIAYICDKGFSLVTGLAPVLEDAQCDLTLTVMPEELGQLEGQFHLHGDPYPGSYVDMYARLAFIQSRICRDLYTPSALRKPDAELLRTIRDLDDSIEEWKDSIPVNNRPSLITTAPQDSDMRFSVFHLQYHHCMIMIHQASSRCASWEQNQETRGTSSSLAISVAASRSFLRGFLYSQLELGSQNLLFTLSYFLQASINLFCKILSRPLDTANQEDLQTIGMISQLIAQHHRDCDPTCYTAKIKFAGRVISELERLARCAIDKAGREQDQAMGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WF26</accession>
    <name>A0A317WF26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_576250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466305.1">
        <property type="nucleotide sequence ID" value="XM_025615126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WF26"/>
    <dbReference type="GeneID" id="37117269"/>
    <dbReference type="OrthoDB" id="4207132at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="267" mass="30785" checksum="5E7EA2D204B29661" modified="2018-10-10" version="1">MYSRWFARSEIEPGTIIQLKRHQWVILQTINEHESQTSPEDLVYNPGPSSTCTLLRCQRVGPYCPVQGYMRIYKQIPIAGTEVEPARTRAQQAGFCCPRELEALRVLTKKQKTSPITPRLLDTKEDKQDDTGVVPGGFVTWIVWEVVPGVRLGDPCGAPEFWAMDSSERNAMREKFKEGIMKLYRWGYYPLHGNGRNLVWHADTSTLSLTDLNHNYMYFVGFLLAGRFKGNPVWSPGIWAAWDLARPPEGCHYYLPRWDKSTEGWEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WF97</accession>
    <name>A0A317WF97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466380.1">
        <property type="nucleotide sequence ID" value="XM_025612035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WF97"/>
    <dbReference type="STRING" id="1450535.A0A317WF97"/>
    <dbReference type="GeneID" id="37114178"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="577" mass="63334" checksum="0C7701EEF3F342C1" modified="2018-10-10" version="1">MTSHETTPSTDIYGPGTYVDKTFLPAPQDARRIFEYIAKSTPGFTQNQDLWNTVDFQGSSLPIIPGPFKAPLIAAALHAMCGVVAHEIIQDRDGTAASTQQVNINVDHAAIWLGTIFAASIEGKDMSELVRTRQLPTLFKRDFEGDFMSSPMRQRTTALYKTKTPGVWYQLHGSLNAAPVLQALGIDPNYPAKNSDEAYEHIARHVEQWAADELEMLNIKNGFCGSICFTPQGWDETSMGKRLAAHPLVGYSRQRHAIPTPPVPLPKVQNDRRPLAGIKVVELVRIIAGPVIGNTLAAMGADVIRVGCSRLTDLNVLQLTLNAGKRTIDLDLTKEEDKSRLRDLISGADVFIQGFRPNAIARKGFGVNDLLEMAGTRGKGIVYVEENCYGPDGPYHERPGWQQIGDAASGSSYVMGRSLGFNDGTSILPPLPISDMTTGLVGALGALMALRDRARHGDSYRVTSSLVKADAIALEPEIGLYSPEVVEKSKQVFQWGYIGPSLFVTEILLVVMDGWKRVFPQYFGGGDESLLMSFEEGPWGKMEILRPVVRLGDDDVTPRWLTPAVPNCYHGRSIDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHH0</accession>
    <name>A0A317WHH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamylcyclotransferase AIG2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_468536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466118.1">
        <property type="nucleotide sequence ID" value="XM_025608253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHH0"/>
    <dbReference type="GeneID" id="37110396"/>
    <dbReference type="OrthoDB" id="3262926at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18574" checksum="219D595B1681F5E8" modified="2018-10-10" version="1" fragment="single">DKNSIFLVKLEGPLSSPTKIKALTGFLTTPILKEGEGIRDTSPSNFCLITGKMKLAILSALEGTFFSPTFIRVNLSPKHLSDYSIAPTLGNEIDPTLPQNRATDADELFLPRQDQFPVWYFFYGNLAVSEILAARLGLQDMPILSRALVKGGVLRTWGGGKYKALVDGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHN0</accession>
    <name>A0A317WHN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_519199</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466168.1">
        <property type="nucleotide sequence ID" value="XM_025610060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHN0"/>
    <dbReference type="STRING" id="1450535.A0A317WHN0"/>
    <dbReference type="GeneID" id="37112203"/>
    <dbReference type="OrthoDB" id="10000533at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF4">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="3"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="307" mass="34157" checksum="07191DDE7E38AF4F" modified="2018-10-10" version="1">MVKVAIAGGTGGVGRTILEVLNASSDHQAYVLSRQPSSSTPNTLTVDYTNVPGLISTLETNQIHTVISAFAVAGDSLATSQLNLIEAAIQSKTVQRFIPSGYAIPYPEESLKVLPQLKDYFKAIEVLRASRLEWTIFVNGIFLDYFGSPALRSYLNPNVFVLDLVNHVAAIPGDGNVPVTFTYTFDLARFVVAALDLLDWPEESRVVGDELTWNEFVGLAEGILGTKFTIYHDSIEKLQRFEITELPGHRALYKAFPQKAFQWFMAIFELFTADGSSQIAMEGALNERFPDIQPLTVREVLERYWQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WI44</accession>
    <name>A0A317WI44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_566970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466348.1">
        <property type="nucleotide sequence ID" value="XM_025614598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WI44"/>
    <dbReference type="STRING" id="1450535.A0A317WI44"/>
    <dbReference type="GeneID" id="37116741"/>
    <dbReference type="OrthoDB" id="4431514at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="458" mass="52087" checksum="F6951A22AA749149" modified="2018-10-10" version="1">MLDRLPDTVLLQCLHREVHLHSGAIPMFGKTIRPPSIISIIENTCRNADIASATQVLVVDDWLVGNRRRESFTTDPVTLKTLLQTAKLSPDQESWWREALDACHQDAWIALLLLQLPNLRKLEIRNMEPGSPYLQSILTRLTDPNDPLTGLTQLSELKVSPAMFGHDFFLSSFIPFAQLPAIQKFHIGGAIDSYPPPPPALFKAASESIRRRAQANGTNTSMGWGISPAQAQYLENISRSSTLAPSVLFPALTAAKPSLQSLWMTTTHRIRHSPRDIFTQDLPGIPIGNLHDLPSLRALRMRVENILSITHASDRTLTNTKDKLWDILPHTLESLFLEDCDRALFPEIINQLQRMLHSREEAQRQELHQETTLFPYLKTVVLQQPREEADRTRFEFPPNMKSISREMMEDVARHRMAENDLQPEVWKGLMEVKEKFGALGVEVRVVDKMRTDGEFLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WIM7</accession>
    <name>A0A317WIM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_517308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466907.1">
        <property type="nucleotide sequence ID" value="XM_025609986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WIM7"/>
    <dbReference type="STRING" id="1450535.A0A317WIM7"/>
    <dbReference type="GeneID" id="37112129"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY86316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="108" mass="12498" checksum="E0E3F2EB97BD31DB" modified="2018-10-10" version="1">MAAPYSRLLDLAKVQCRIFSLNFNPERLRLGNKILRQRLRGPALAAWYPRKTISFKDLQETCSRSGLTTFDEYEDDREEAIQIAKLRGKGRPKKKRTAAESRSAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ61</accession>
    <name>A0A317WJ61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_466575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467077.1">
        <property type="nucleotide sequence ID" value="XM_025608169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ61"/>
    <dbReference type="STRING" id="1450535.A0A317WJ61"/>
    <dbReference type="GeneID" id="37110312"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016238234" evidence="2">
        <location>
            <begin position="21"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="36"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY86486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="507" mass="55309" checksum="A1D7C1E539EDDBE1" modified="2018-10-10" version="1">MRRNVILVACLAALSSVSDAFWRLPCRGRSGVARIDPLMAPGKPSDHVHVVHGSGGFSMSATEMSLKKANCTSCGVTQDQSAYWVPALYFMHENGDAELVNEVGGMLAYYFLNGENVTAFPENFRMIAGDPFLRNFPWPVPDPPKSEWSGNQSSQSALRQKALGFNCLNYNQAAEPSLGRHFLPNKTFLDEHCTDGVRFELMFPSCWNGKDVDSKDHRSHMAYPSLVMDGDCPEGFETRLVSLFYETIWDTYAFKDKQGTFVLANGDPTGYGYHGDFIFGWQTGVLQRAVSECTNLSGRVEDCPIFDLQSEAEQGQCSFAVPDELKDENVYLHKGGLPNHVAIQSGPAYASPVKYTGLSHHTSPAVSEPSVSIGVSINVGDVHVGVTATALSTFSTLTSPTATLFSTSTTSSAPTTSWTPDPTTVYVEGVFTQKIVYVQQEFIVLTDETGAPVQTETGALETVSTSTSTINKVMSTIVTTPTESPVQHDGHSHHVHRRHGHGHAHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ97</accession>
    <name>A0A317WJ97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_535599</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467034.1">
        <property type="nucleotide sequence ID" value="XM_025611825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ97"/>
    <dbReference type="STRING" id="1450535.A0A317WJ97"/>
    <dbReference type="GeneID" id="37113968"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="339"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="555"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY86443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="818" mass="92431" checksum="98404166A694C50D" modified="2018-10-10" version="1">MPIKRKATDSGRSSRASKRPTPVPDIGSSDEYSDYEDEIKDDNLKDVLEKFSLESFSNQKSAVPRQDPNFGYKDFSSLSLKPDHANRPLWIDPLKGTITLESFSPLAPQAQDFLTTIAEPLSRPTHLHEYRLTGNSLYAAVSVGLQPQDIINFLDRLSKTPLPDAIKSFIIDFTKSYGKIKVVLKHNRFFVESTDPAMLQMLLQDEVIGSQRLKGAEGIIQQAAPKMGGLVIPGTRDAAGVKQASEQKPAEDAAGEARKEDDILLAIRDDDDDDEQAQVHSFEIPNEAVEPVKARCQAMGCPALEEYDFRNDEINPTLDIDLKPAARIRSYQEKSLSKMFGNGRAKSGIIVLPCGAGKTLVGITAACTIKKGTIVLCTSSMSVVQWRNEFLRWSNIDPGDIAVFTSDNKEKFRRSTGIIVSTYSMVSQTRARSHDAQKMMDWIQSREWGLMILDEVHVVPASMFRKVTSAIACQSKLGLTATLLREDDKIKDLNFLIGPKLYEANWMELAEQGHIAKVQCAEVWCPMTTEFYSEYMREKSRKAALLYIMNPRKFQACQFLIDYHEKRGDKVIVFSDNVYALERYALKLNKAYIYGGTPQNERMRILENFQHNEQVNTIFLSKIGDTSLDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTDEMFYSSKRQAFLVDQGYAFKVITHLQGIENLNGLAYASPHERRELLQEVMLQNETSAEVEHVTDDLFSGRSGGQARKGGVKRSAATLSGLAGGEDMAYIEYNRSRNKQLKDKAGHHPLFRKLERERLKRKKELEDFMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKF7</accession>
    <name>A0A317WKF7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="7">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25 26">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="30" type="ORF">BO94DRAFT_575611</name>
    </gene>
    <organism evidence="30 31">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30 31">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Chromosome</location>
            <location evidence="4">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="30">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467136.1">
        <property type="nucleotide sequence ID" value="XM_025615083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKF7"/>
    <dbReference type="STRING" id="1450535.A0A317WKF7"/>
    <dbReference type="GeneID" id="37117226"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000603">
        <property type="entry name" value="EKC/KEOPS complex subunit bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000845">
        <property type="entry name" value="Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="22" id="KW-0010">Activator</keyword>
    <keyword evidence="19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 30" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="20" id="KW-0779">Telomere</keyword>
    <keyword evidence="23" id="KW-0804">Transcription</keyword>
    <keyword evidence="21" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="29">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="PWY86545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="271" mass="29449" checksum="084BA40D11867862" modified="2018-10-10" version="1">MTLITQGAEAHLYKTTFLTPHHPAALKIRPSKPYRHPILDRRLTRQRVLQEARCLARLVREGVNVPAVLGVDWDVNSSSNISYTGDGNGEGNKGAGVGAAWLLMEWIPGDVIRVVIQKWEGVLNRTQGEDAEAGEEKEVGDLLRRVGGAVGALHKAGVVHGDLTTSNLILRPKGASLEEIGGKGEGEGGKPNMDGDIVLIDFGLASQSIQDEDRAVDLYVLERAFGSTHPRTEPLFGEVLEGYRGSYRGAGSVLKRLEDVRMRGRKRSMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKY2</accession>
    <name>A0A317WKY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Citrate exporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_467356</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transmembrane transporter that exports citrate across the cell membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>citrate(in) = citrate(out)</text>
            <dbReference type="Rhea" id="RHEA:33183"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466734.1">
        <property type="nucleotide sequence ID" value="XM_025608201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKY2"/>
    <dbReference type="STRING" id="1450535.A0A317WKY2"/>
    <dbReference type="GeneID" id="37110344"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="59"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY85717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="523" mass="56918" checksum="C641A31B6D3ADB2C" modified="2018-10-10" version="1">MSSNMSSRTDIEKVPEPQVTPKDHDSERDSISPEPSMLESQPSEKPPHHIFTRSRKLQMVGIVSLAAIFSPLSSNIYFPALDDVSQSLHISMSLATLTITVYMIVQGLAPSFWGSLSDATGRRPVFIGTFIVYLIANIALGESQNYGELMAFRALQAAGSAATISIGAGVIGDITTSEERGSLVGIFGGVRMLGQGIGPVFGGIFTQYFGYRSIFWFLTAFGGVSLLSIMVLLPETLRPIAGNGTVKLTGMHKPIIYSITGQKGVIEGAQPDARKGKVTWRAVFAPLTFLIEKDVFITLFFGSVVYTVWSMVTSSTTDLFSEVYGLSSLQIGLTFLGNGFGCMSGSYLVGYLMDYNHRLTEREYCEQHGYPAGTRVNLKSHSDFPIEVARMRNTWWVIAIFVVATALYGVSLRTHLAVPIILQYFIAFCSTGLFTINSALVIDLYPGASASATAVNNLMRCLLGAGGVAVVQLIIDALTAEYTFILLAGITLAMTPLLYIEDRWGPSWRHARERRLKAKANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN33</accession>
    <name>A0A317WN33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_55329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467602.1">
        <property type="nucleotide sequence ID" value="XM_025613646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN33"/>
    <dbReference type="GeneID" id="37115789"/>
    <dbReference type="OrthoDB" id="10403699at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="112" mass="12161" checksum="B57CE1D592EDCDEA" modified="2018-10-10" version="1">MSISLPGPGAPVELKKPAPQSQMRLSFPDQLRPGVSYTELARSGGLAQMEFEIDVLTGRLTMVDGGGHCIPATSLPDWRHRIRLEADTGNSGHPMTSLTDRFLPEPSDTSQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPG4</accession>
    <name>A0A317WPG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_585719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467360.1">
        <property type="nucleotide sequence ID" value="XM_025615712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPG4"/>
    <dbReference type="STRING" id="1450535.A0A317WPG4"/>
    <dbReference type="GeneID" id="37117855"/>
    <dbReference type="OrthoDB" id="5344482at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="36350" checksum="BE55B18DFBCCE03B" modified="2018-10-10" version="1">MSHSLPTPFTPNSDFAALDAHRFPTGTISITALARFEFEAGKANDGTKILMIEWEDDDLARSSFPGGSWHVAWEGKMAVLPADEKTSNNTRRMYFLLPPYITIPPTVTLSYEPPAHAPESAKNPEPLQLNPLPAIFPPELGADGRSAGKKGVLHTIWAKKRLQVLEKEIHDECLHNAEGIALHMVLQEKEWIETNFGVSLSPDGARVVGQSHPDPHYPMGPATPVSPSSGGKLGEKLRGLKLQTSERELSPTTGHHLLSPQSPDVAVSSFNSFHTMRATHTPTPVPDTVRTVVHYPPESVQAQQNVEHHTGFASLGQCAQATATATATSYLPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQU5</accession>
    <name>A0A317WQU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_52217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468165.1">
        <property type="nucleotide sequence ID" value="XM_025610170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQU5"/>
    <dbReference type="STRING" id="1450535.A0A317WQU5"/>
    <dbReference type="GeneID" id="37112313"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006222">
        <property type="term" value="P:UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278">
        <property type="entry name" value="OROTATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19278:SF9">
        <property type="entry name" value="URIDINE 5'-MONOPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY88803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="451" mass="48956" checksum="37309437F5D73FCF" modified="2018-10-10" version="1">MDTSSSLDCPSFPGNRIVSYLQTLAKSKSELPYGLPVCVSPSHTITTTDSLLNLASLVGPHISILQVHADIIDDWSEDTVRQLSTLARKHGFLIWESGRILNATVDVVGRQKTESREARNGAVDLIRKKYTRGVVKPASWAGISTAWASGAAVYNQEADILIPTLKAAAREAVADTVQTIRTEITANSFANENSVDDQDSTQPQHLTEYAVDHSGLGLPPRKASTISLTQTITQHTEDSSDYPLESPQFERHGFEFGTLSPSTIPEDLPPPPLLARGLVLCLPSRTDTSFTPDYRQSCIAAARANQDFVVGFLSGEPWHLTSQRTDIFETGLPSYGDEQQQLSPYSSDDDEALPHFALFSPIAQRHDGMGGQLLEGGDGDEEVMEEDETTSSALPETSIPIESLNPLAAKLFHVAGKAFKLREASTQENGVAKPEPTKSCQILHIPIVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRK2</accession>
    <name>A0A317WRK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_534937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467715.1">
        <property type="nucleotide sequence ID" value="XM_025611659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRK2"/>
    <dbReference type="STRING" id="1450535.A0A317WRK2"/>
    <dbReference type="GeneID" id="37113802"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY87932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="122" mass="13829" checksum="022986E69F7967D0" modified="2018-10-10" version="1">MADAQKQMQALTDEFQALQTELDGLVDARQKLESQQQENLGVQKEFDSLDDEANIYKLIGPVLLKQDKNEALMAVKGRLEFIEKEIKRIEGHIQENQDKADNKRSEIVQFQTQLQQAAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSG7</accession>
    <name>A0A317WSG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_585050</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468033.1">
        <property type="nucleotide sequence ID" value="XM_025615670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSG7"/>
    <dbReference type="STRING" id="1450535.A0A317WSG7"/>
    <dbReference type="GeneID" id="37117813"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY88671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="521" mass="59043" checksum="484A779DD02CDF43" modified="2018-10-10" version="1">MNQTYCILSALFLYALYTICLAIYRLYLHPLAKFPGPKKAALTKWYEAYYDLIKSPGGQYMHEINRMHDVYGPIVRINPDEIHIRDSMYVNTLYCNSVGGKRNKYPPAAHMTGTPEGIFGTVNHEIHRKRRSAISPLFSKSTVTAVEYRIQQKVRILCDTLRSQIVHHGWAELRLNFLAYATDTVCEHSFTNLHLDLLTSDRRARQWRDSIHAIAILTPWIKQFPWVLPVALNLPLSPLYALVPVVARVVELRRAMDKHASEAVRDFFESAQEPQESKAQGLFNSILSSTAIAPSDKHPLRIAQDGFVIIVAAGETTARMLTTAAFHILENKSTILPRLRQELESAMPVPGAAAELAKLEKLPWLSSIIKESLRLTGLVTSRLPLVSPDQPMTYRDWLIPARTPVSMTLRDVLLDPKIFDDPYEFRPQRWLDLTSDMEHAYVAFGRGSRMCVGMNFALAELYQCIAYLFRNMDLELYETLRERDIDIVRDCFIGEVSPSSVGVRVTLATPSHTAAPETGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSI6</accession>
    <name>A0A317WSI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rxt3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_545418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468334.1">
        <property type="nucleotide sequence ID" value="XM_025613235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSI6"/>
    <dbReference type="STRING" id="1450535.A0A317WSI6"/>
    <dbReference type="GeneID" id="37115378"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="917"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1049" mass="112654" checksum="B9BFB50B2A247E01" modified="2018-10-10" version="1">MPRSGVTPTYSYPTPSSAPASVPSVSYAHENTYASFRTDSNGYHIASANHGSLKEQNLPGSNLDHDSRQGPNPNPNYLNKQDRRMVYREAPLSPFACDMNPPPSHDQGRRRSLGSSGSPAFPGVQEQQPAAPPLGTRRMPPPSPPQHYPSRNQPGNAPSLSTPFLSREPPSNPAHHRPGSSMSISSMLGSDADRPGRDVGSSSIFSRLPVSSAPYGNAHPPSAPGAMSPPTAPARPSPLEYPSFRRSQTPEKPFAKNQPSRPYRSGSGGVPQTIADQAKFGGLSRVPPSSQYPDKPNSTHPSPQIASAEAPYNEPRRLSFSGPVPRPSSQPQHLEPPARTTGYSPLSRPVAVAGVGDGPFAATHQRAASYMGHEPQHTRYGGLYADRHAEEQAHRDRERAIAHEAESKAASHPPSRYGPPYGDRETAAHRPQGASAWDVGRSQPPSPETKRFPVPEPGSGFGFGAIQSYTKSLAVTLRSSPPSQPPPPSHDQPPYLSKLQTETRGFPATSSSVGPPSLIHSASSDDQRRKGSDELLAHRNLLGVGLDSKRGGRASPLPQAVQGAQAQILGPAGDSGIKNELGRVFSGIGSGVGGVTATAGGSGPSTPMAPSPFKRDSAPGRSANGETTVDDIRISRPTSANGKRQRKSRDEDSRAESEAASLGAARGRRNRHLHHHHHQYVSPGYNSLHAFHADVPSHHHHRHKPEEEAAAAAAAAAALGSSRPLSSVNFFHRTATPGEGTPSATGSALGHHHHHHHHHHHHAPRPAAAGGSAPAVTPMREPRTVVTIEPLLATVAHLPRHHLGSTLYAPRIGVPTEKATLESAKFGYTTTPLPLPRFEGKENCTFTIRVPRFRIDTGHREEICARRALWGTGVYTDDSDPVAAAIHSGFIRGAWGEDVDVDLLDLEIKDAYQHAPKTAQDVGAEDGERPRVPPIPPTDKDLHITLLILPRLEHYDSSVLFGLKSRAWEGSHDGMSFKVQRVEWVDEGVGRGEERSGEARRKRLRNLMQTGRICTGPGVVKLEQLRNGVQIPRRKQLESQEQPSPMPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSJ3</accession>
    <name>A0A317WSJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sure-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_516043</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467621.1">
        <property type="nucleotide sequence ID" value="XM_025609949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSJ3"/>
    <dbReference type="STRING" id="1450535.A0A317WSJ3"/>
    <dbReference type="GeneID" id="37112092"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="771" mass="86561" checksum="0607D336777CAF9A" modified="2018-10-10" version="1">MHILVVNDDGPPSNQSSPYIHSLVQSLQSAGHTVSVVLPHQQRSWIGKAHLIGAAVRPTYFRPGTLHKDDGTTHEFPHGMNEGDDENYDGDEWILVDSTPASCVQIGLYHYFQDRGPVDLVVSGPNYGRNTTALFAMSSGTIGGAMEAAVCGKHAIALSYAFSSRDHDPIVIAEASRHSVRLIEYLHNNWVDGVDLYSVNVPLEPGVSESKVLYTNMLDNRWSSGSCFRAVDASSSTSTPGEHEHDVRHQAVDGAAPVKRSRIPHKHFEWSPNFTDVYRSVEESAPGNDGWTVKEGMTSVTPLKANFMHTPGIQGEITLLCIARVAVLPSDCLLLVCLSISCRPDNNTEPTFYTLVDSDDSYVQSLMKRALQRRLGNGQCRAISSLSDLPSRTTPVFQYREYERLEFEHIMVHSSTSLANAYIIRKALIRKHYLSNTVTNWVTKHPESVLAKHFKFAFDFELDYAEFLDDALLEAYELRDSLDKNETRPDEEKEWWILKPGMSDRGQGIRLFNSEDGLREIFEEWEVDDSDDESGSERPEPENDDPEDNGVVTSQLRHFIAQPYIDPPLLIPSSHNRKFHIRTYVLAVGSLKVYVFKEMLALFAAKPYCPPYEDEDEVKDLARHLTNTCFQEGGSSNKDSVRRFWQLEDYVPGLTCSWKQNVFDQICAVTGEIFEAAARGMMVHFQTLPNAFELFGVDFLVDKSGNAWLLELNAYPDFAQTGEDLKEEVVGRLFEETVDVAVKPFFGLGDAETKGTEMLKLVADLDLGRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSN8</accession>
    <name>A0A317WSN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_71480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467428.1">
        <property type="nucleotide sequence ID" value="XM_025617618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSN8"/>
    <dbReference type="GeneID" id="37119761"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="282" mass="30550" checksum="0E570CDC72975731" modified="2018-10-10" version="1">MEMTAAMDAAESIVLLPAAVSSDPVRWARFPSIQVRGHSSWADTPTAQKDGLMSFLDITSRLLECSGWFEGWRFQPFIARISWRHCQTPEPWGGASTVSVTVSPTRSTAGPVTLCSFFCRHLPLRKRNRSSPSLPLGLAGIPVGSLDRSSQFLGYLPTPSEASKPPTLSRHDSANCQEGSRVPEQVPLPSIPALCLSLYCGHWTLDGLPSDPTDSSVPTQATESSPIQAGFKVIDTVPTLPSLKTRALTTNCCRSSSRIHSHFTPSHPPTTLLIIRFMAAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSQ6</accession>
    <name>A0A317WSQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_466337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467458.1">
        <property type="nucleotide sequence ID" value="XM_025608155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSQ6"/>
    <dbReference type="STRING" id="1450535.A0A317WSQ6"/>
    <dbReference type="GeneID" id="37110298"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016397527" description="peptidyl-tRNA hydrolase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY87250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="464" mass="50711" checksum="CB61042821D008D4" modified="2018-10-10" version="1">MRFIQVVALLPALAVAQEQVPLADRVQGWFNKAKSYLPTATPVVPAAVVEKVVEKAVKIQEKTVTPFNVTNWQSFLEPSSEAQDWLVYVTGGNKTCFGRCDQADKSFNESVLLFSADPTSPNLGKLDCESNQVLCSAWGAGTPSVWYFQVPQAQLGEERPPTALHTVYLNTTTVTPETIYKVHSEKVYETTPAYEGALHPTDGWLAQNGLLLPLGYVIYGFSAIPSWLFMILISFFSRTFIVVSGCGDPDIYRSSQYPLKMADFDRTPPSTAAYVVATAILAGITGYFIGQGSSLGLFSTKEKEGWPNSYNVKVHRDSSDEYESEEEEDSEDEGDGTELGNFDESAEEVKLVLVVRTDLGMTKGKIAAQCSHATLACYKYLVAYTPSSGMLRRWESQGQAKIALQIKSEEEMEELQAKAMSLGLCARVITDAGRTQIASGSRTVLGVLGPKSVVDSVTGHLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WST0</accession>
    <name>A0A317WST0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_584679</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468327.1">
        <property type="nucleotide sequence ID" value="XM_025615642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WST0"/>
    <dbReference type="STRING" id="1450535.A0A317WST0"/>
    <dbReference type="GeneID" id="37117785"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY89416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="48929" checksum="21DC629B621739E5" modified="2018-10-10" version="1">MSSSETTPLLHERGSSPAPRTDYRTLSLVVGAVIFLAKFADELLKAPMLDALELAVCQRSSPTTPCDGTSVGPVVASLRGMAGMLDALPGLTVGYVYGSLSRNWGKRTVLLLATLGMALEVAWFVLVCAQPSIFPPSAVLGGFAFLFIGGGPQVFNALLLTILAEVVPNTEQTAFFWRAGAAGLVATFIAPPASGAMMSALPAVVVCGVGVAIFSLLFPLILCLPGTTAAATQVERVAAGEHAQPPKSILQSIRSGWKENTSLISGLLSHGGIIRSAAFADLVSTLAPNIMVILLQHMSNRFGWSHAEGTLIYSIKGGISLFLFTVGLPWIHRYLTHRLRLSSPWPDLWMSRALIIFLLGGSFLIGVAQTATWAITGLALFSCGTGISMSLKSASVIGLPKDQVARLYTGLAAVETLGAILGSPLLSWVYAASLHAHNPAFEGAPFLLSSLAYSAAAIAIWTVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTF3</accession>
    <name>A0A317WTF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial division protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable E3 ubiquitin ligase complex SCF subunit sconB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfur controller B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sulfur metabolite repression control protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_33404</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SCF(sconB) E3 ubiquitin ligase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468286.1">
        <property type="nucleotide sequence ID" value="XM_025607002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTF3"/>
    <dbReference type="STRING" id="1450535.A0A317WTF3"/>
    <dbReference type="GeneID" id="37109145"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="15">
        <location>
            <begin position="138"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="332"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="372"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="413"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="453"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="493"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="533"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="607"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="623"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY89375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="666" mass="73412" checksum="D110FC775DA882C3" modified="2018-10-10" version="1">MSTHNPAGNGMSPRSLPEQLATAPSRSSAARDSVASLSSTHSRSLSSSTKAGTPIPPSLLPSAPASPPTPAPSPTPHQRPPTWQTVEEEDDAFLLNARIHFTSLSNARKLKFLEGILGLCDSQHLSFVSSYVSPRLRKDPFQVFPNELCLRVLSFIDDPKTLARASQVSRRWRELLNDDITWKNLCEKHSYASRRMSEDDRDFVDPFHGQPLHAVSSTQSLSGLQRRPNVSSLQSRDGLAEVSRSLSGDWLSMSGYPSRKRRVRPLSYRLHFKQKYMVESAWNKGGRFNQRHITPDQGVVTSLHLTPKYIVVALDNAKIHVYDTNGDNQRTLQGHVMGVWAMVPWDDILVSGGCDREVRVWNMATGAGIYLLRGHTSTVRCLKMSDKNTAISGSRDTTLRIWDLATGTCKNVLVGHQASVRCLAIHGDLVVSGSYDTTARIWSISEGRCLRTLSGHFSQIYAIAFDGRRIATGSLDTSVRIWDPHSGQCHAILQGHTSLVGQLQMRGDTLVTGGSDGSVRVWSLTKMAPIHRLAAHDNSVTSLQFDSSRIVSGGSDGRVKVWSLQTGQLLRELSTPAEAVWRVAFEDEKAVIMASRQGRTVMEVWTFSPPPEEDGDDTVIVESASSTPGLHPTNNDNRHRERFSDPPPSLPLSNDDDQAMLDAPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVF5</accession>
    <name>A0A317WVF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_555522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468717.1">
        <property type="nucleotide sequence ID" value="XM_025613805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVF5"/>
    <dbReference type="GeneID" id="37115948"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016366483" evidence="7">
        <location>
            <begin position="33"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY90339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="468" mass="50561" checksum="1DD3AD60F2BB2C8A" modified="2018-10-10" version="1">MPLLGPSKLPDRSSRWRLLALICFVVLVQDFAEYIARAPQIEIWIEIVARKLCPGVQDGSGCMDLVQSEVALLEGWKDTLEQVPGILFAVPYGVLADRIGRRPVLLLCAVGFTLSDVWVKIVCWFSDQLPLRLIWLAPIAEVVGGGTQVATSIMFVMLADLFNDEDQTTAFLYVSATALLSEILATPLGTLLMTRNVWLPYILSSVGTAGGGLFLLLLPETLPQAPPSSPSGTSREEEADKGNIPDRVRAGVDELRRSTAVIRRHRSVQLFLFVFFAAYLGRQVMKVLLLFAANRFHWTIAQASFLISVRGFTNLLLLIVILPGLSRWLLRRWNMTPLSKDTSLALTSSACLCVGCLLIAVSVHPVGAVLGLVVFALGSAMHLLARRIITSLVDAHHLGTLYTAIAVMQGIGVVVAGPTMAMAYGWGLAQGGVWTGAPFLLVAGLFGAAGMAILLGSWEEGRGDLESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW58</accession>
    <name>A0A317WW58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_545347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469004.1">
        <property type="nucleotide sequence ID" value="XM_025613232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW58"/>
    <dbReference type="STRING" id="1450535.A0A317WW58"/>
    <dbReference type="GeneID" id="37115375"/>
    <dbReference type="OrthoDB" id="4869816at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY90626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="254" mass="29201" checksum="429C87B019386785" modified="2018-10-10" version="1">MTYTPPGWTEDRLRVATVDDLRQIPEDRLHKIDDEILENVEARKIVCEAQHNEYYRLERERRGLPPAPPKPLFEESVDAVVQVVERAGFDDFGFIVFRADYSDEKYWDKWQELFLKRLDDSLAQASGGRRIEDKLFTPIFDDRDSINASLERIQEAYNSYDENEGVPPGLGTGMCLVVDKNAMESLLNPVAGEDPWVIAMDLSFDHSREVPEGEYPGYFRVAVDSVIPEFYPFVSIMTPPELWASANPIWVSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW83</accession>
    <name>A0A317WW83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_555506</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468693.1">
        <property type="nucleotide sequence ID" value="XM_025613802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW83"/>
    <dbReference type="STRING" id="1450535.A0A317WW83"/>
    <dbReference type="GeneID" id="37115945"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="159"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY90315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="312" mass="35195" checksum="D40AA5424442CBD2" modified="2018-10-10" version="1">MPPPNSQPGEFDEIPIIDLSTLRSPLLKERQQLAKDIFNACTQVGFFYIKNHGIAEDLISSLHAMAHRFFRLSEKQKLDYYIGKSNKYRGFMPLYSEQPTGTDLDSTPKPDPTSPGAFSESFDIGYETAADPLKSPHDALPPDTYALELPEDFFDPMVKYPGATSRMLHYPPQPVANEVRIGLGEHTDYECFTILSQDQVPALQVLNARQEWILAPPISGTLVVNISDCLSIWTNKRFKSTIHRVTNLTGQERYTIPFFFGVNYETTVSVLPNCISEDRPACRQSFKAGQWVRHQLTTAYVGYGPEPPVEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WX53</accession>
    <name>A0A317WX53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">INO80 complex subunit F domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_514632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468289.1">
        <property type="nucleotide sequence ID" value="XM_025609897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WX53"/>
    <dbReference type="STRING" id="1450535.A0A317WX53"/>
    <dbReference type="GeneID" id="37112040"/>
    <dbReference type="OrthoDB" id="10070927at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056513">
        <property type="entry name" value="INO80F"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24245">
        <property type="entry name" value="INO80F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit F" evidence="4">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY89378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="257" mass="28095" checksum="C53E85F4CFBB8AF3" modified="2018-10-10" version="1">MDDTATTRQPSTTSNPPSVENAYKRKCLALKKRLNEIEEENELMRVRNRRGWQYIQKMRLESCILLERLAKVTGMTEEAQAGVNPELRARAAAMMTNISSLTGGNAEGKNGGSVPLYLDDETEGSSDEQPPTPQERPLRVKRSRKSNLPNDAGLEDEPANNNTGNKDKESNKDVTESGAAGGASSSSLPRLAPAPSQEEMTSSFRIQTGRNGSAHDKDSSDRGSNNPESAEQRGDAVEDETTPMDMDAKEPKEEREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYR0</accession>
    <name>A0A317WYR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_555330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469231.1">
        <property type="nucleotide sequence ID" value="XM_025613785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYR0"/>
    <dbReference type="STRING" id="1450535.A0A317WYR0"/>
    <dbReference type="GeneID" id="37115928"/>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="86" mass="8133" checksum="D153C43D679D9B41" modified="2018-10-10" version="1">MPSSQDSGVTGAAKFVTSTLGNTVGGVSRTVGGVTGAAGRGVGDTITGATGSAGKPVGDALGSVGTGVEDGARRIARGIEDAGQWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYT4</accession>
    <name>A0A317WYT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CwfJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_533700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469282.1">
        <property type="nucleotide sequence ID" value="XM_025611378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYT4"/>
    <dbReference type="STRING" id="1450535.A0A317WYT4"/>
    <dbReference type="GeneID" id="37113521"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="302"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="486"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY91554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="547" mass="60497" checksum="4E39A33DBE3D5751" modified="2018-10-10" version="1">MASKIVVLGDIHGELRDVFTKLAKLHAKQNFSLAIVVGDVFGDGTTEQEQEQVTALLQGELAVPLPTYFTLGRRPLPARVVEAIESKDEVCSNLYFLGRRATLKTSEGVRLVALGGQLESAGQSSDKFQPAYTESDARALYGAHQADILITHQWPKDIRAGSNAPLPDHASPPAEVQCVADLCSTLKPRYHLCSSSAGFFWEREPFFHLPTEDNPDAKPLTRFISLASYSKTTKTKWMYAFTLDPQAAPALTIPAGATAIPFAPIASKRKPLQSQKDSYRRFAVDDEDHRPRKRARAPPPGPDQCFFCLSNPNIATHLITSIGDESYLTTAKGPLPTSKTFPALDFPGHMLIIPFTHTPTLNSITDDAARQATYAEMQRYRTSLHSMLQQRANNALGSVTWEVSRGNGIHVHWQFLPVPSSLINRSLVDAGFRVEAENLKYPKFELASASTTDPSTEPGDFFRVWIWAPSDKNGGSGEDAGSEKTLLLPLGPEFRFDLQFGRRVMAKLMGLEKRINWKDDVQSQEAEEADAVAFKEAFKEFDFTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ01</accession>
    <name>A0A317WZ01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_574427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468361.1">
        <property type="nucleotide sequence ID" value="XM_025615019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ01"/>
    <dbReference type="STRING" id="1450535.A0A317WZ01"/>
    <dbReference type="GeneID" id="37117162"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF315">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE MDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="16"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY89450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="476" mass="53384" checksum="68998DBB3081FF6B" modified="2018-10-10" version="1">MTVTTDCPKRYPATDISVLIVGAGVAGLMAALECWRNGHNIRIIERSPEQVTTGDSFTIGPSAIRTLNHWPKMVEENEKVAHNPTISFHSLDGTRVTAPKHLDYKQGQDSKNVPGQVHRHWRPQFHAMLLKQLSAIGVDVEYGHRAVKYFEDGPTGRGGIVLENGDRMDADIVIAADGVGSRSTRVTMGREIKARPSGEAMYRTAFPVEIAMADPVVRERFPMVEGDEGSIELWVGEQVRFFIGRTADTISWILSHKDYANATESWSHNSNPEDVLKITATIPDWPEAADRLIQLTPKNRLLHFRVMWRDPQPSWVSPAGRIVQIGDAAHTYVPASGNGATQGIEDAVSLATCLRMAGKTDEIPWALRIHNRLRFVRVSCLQKLGLINQKGYSQALSKGDHTPKGIQYLTAEWIWGHNPETYAEEHYNKVLDHLQQGTRFQDTNIPPGHVYRDWTIDEILSQLERGEEIELNGDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZJ7</accession>
    <name>A0A317WZJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_564532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469534.1">
        <property type="nucleotide sequence ID" value="XM_025614429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZJ7"/>
    <dbReference type="GeneID" id="37116572"/>
    <dbReference type="OrthoDB" id="3259529at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="288" mass="33103" checksum="219166148DA01989" modified="2018-10-10" version="1">MSWLKHHPLSSLGTASQDRLDSDNKTNDSGDCSDTESTYSNECASNHEYGMDDTLAVTQVLEQHSIPCCLVGIAALVFYGAGRVRDDWKICVSTELVGQAAELLQSEPYATQYRLVKPWPYYSPCSLIHTYHRFKSRGINHYFFLVPLINMHIDCDPSNFTRSPRGLPYLKLDVFIQSYLDTCNMLQLCDVIDSTNVSEKWGENNLNLEDTNDVEWAKEKNKRGEEFGGEWANSLFAWEGRRNKREMWLSLVRTKEDRLDWTKPKDVFITQHRVIGAPDPWTELSDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZT9</accession>
    <name>A0A317WZT9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Maleylacetoacetate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_533342</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Zeta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469632.1">
        <property type="nucleotide sequence ID" value="XM_025611309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZT9"/>
    <dbReference type="STRING" id="1450535.A0A317WZT9"/>
    <dbReference type="GeneID" id="37113452"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03191">
        <property type="entry name" value="GST_C_Zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000010">
        <property type="entry name" value="Maleylacetoacetate isomerase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005955">
        <property type="entry name" value="GST_Zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034330">
        <property type="entry name" value="GST_Zeta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01262">
        <property type="entry name" value="maiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="125"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY91904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="257" mass="28665" checksum="665C0A32FC3F103C" modified="2018-10-10" version="1">MYLSSTTTTNLNTNLTSTSNPKMTTPLTLHTYFRSSCSARLRIALNLKSLPYESIPINLLKDEQHSTPNTTLNPSASVPTLIHHHDNQNQPSFKTPTIVPQSLAALEYLEEVYPEAHPLLPPLTCPETRATVRTLANIIACDVQPVTNLRILKRVAPLGMDRTTWSKELVEEGFRAYEEIAAKSAGVYSVGDRITLADVCLLPAVWGAERVGVEMGEFPTIERVRGNLERVEEVRRAHWRCQGDTPGEFRVGFEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0L7</accession>
    <name>A0A317X0L7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_27741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468896.1">
        <property type="nucleotide sequence ID" value="XM_025606602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0L7"/>
    <dbReference type="STRING" id="1450535.A0A317X0L7"/>
    <dbReference type="GeneID" id="37108745"/>
    <dbReference type="OrthoDB" id="5401558at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="125"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY90518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="307" mass="33089" checksum="351040E68ECE2B80" modified="2018-10-10" version="1">MAAMHPHVQAPQDPYRLPPPPGSYRPGDVYAQPPPPPQVVYQAAAPRQRTAIACRYCRRRKIRCSGFESSQDGRCSNCIRFNQECMFTPVSSQAQAFVPAHAAYPHLRNAQNQGRAGAPGVMLYGAHGQPLPPQQQPEGTLPPPQGMYQHPYGNAPPPLANGAPDHRPIGRRGSGSGFEYPDPTNLAPVTPATSASGYQTYSATSPYYPPPQHDRRPSPQSTYPYDGRHSSSPHSSPYPPMHSNQGAMTPPPTSTPGGSSRSGLNVRDMLNPGEQGQGQGQGQNQGQGRSSTDSDMLNALNRRVLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X114</accession>
    <name>A0A317X114_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_583791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469599.1">
        <property type="nucleotide sequence ID" value="XM_025615581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X114"/>
    <dbReference type="STRING" id="1450535.A0A317X114"/>
    <dbReference type="GeneID" id="37117724"/>
    <dbReference type="OrthoDB" id="3938867at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="560" mass="63936" checksum="2A89B5F6C262EE86" modified="2018-10-10" version="1">MGTRGLEIVRFNRRYYIRYNQYDSYYEGLGAQIVASIPTDPEEYQTEYAAIESALEAHVYEIRDGIEPNYSLFSEFEELPSELPRLDSHDAEYIYIINLDREVLTMNYSIHWKLGNIPRQDNLWIRAIANSIYMYKPTISLDVCPEECMGSLALELPKPKGVIEFGCRYVTPKTNITDAPKAFLTRVLAKVLVQYKEEIIRFGREWSADSFPFRELAFALVSIASGQSKFHSIPAQLCNPWTCAAWNCNLNHIGQSPGLLDKEWAGDSAPLLEFGSSSHRPGEPPGTSPTETIYWLEDVLVSLTLVIDDRAIMKAVDWGIKQGRTSFQIVVLSLFEVVFAEVSPEDGGDFFIKLSEAVNLSPLHANYCVSTHPRTRPEVKSGMKARHHRGELLMKSNCTGTIRRLRTQFPGLAALVNFFEVAANRRAASKSRGTLPLVIYSRILDFLDYDTWKTCLFVPTIRSCCLRKYRLDDRVSIVAGPFVRLKQNFHKDRLMSFNFESIQTGKILPMVEFPRSFQMQEYNWMPMIGRDRTAVMLDVAIQFQPAEDMPVEADSDDEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1C6</accession>
    <name>A0A317X1C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_584025</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469130.1">
        <property type="nucleotide sequence ID" value="XM_025615599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1C6"/>
    <dbReference type="STRING" id="1450535.A0A317X1C6"/>
    <dbReference type="GeneID" id="37117742"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080042">
        <property type="term" value="F:ADP-glucose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080041">
        <property type="term" value="F:ADP-ribose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000068">
        <property type="entry name" value="NUDIX family hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="106"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="284" mass="31371" checksum="0577074161120AA1" modified="2018-10-10" version="1">MSISTFTIPRDLDHDVSSPLHISCAAELSREDLLRFPAFRVWLTTLQRSLSRQQHPSHEFSKDPYVLRKIDIQAVDYFGGGRLGFLKLKAEVSNGNGETLPGSVFLRGGSVGMLLILQPDDVPHSAEEEKRAILTIQPRIPAGSLAFPEIPAGMLDDSGSFAGGAAKEIQEETGLKIPQEELLDMTSLALRSVAEPDDGETLQKAMYPSAGGSDEFIPLFLCQKRMPRKEIDNLQGRLTGLRQHGEKITLKVVPLRDLWKEGLRDGKTLAAWALYRGLKEEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2Y9</accession>
    <name>A0A317X2Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_461072</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469750.1">
        <property type="nucleotide sequence ID" value="XM_025607912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2Y9"/>
    <dbReference type="STRING" id="1450535.A0A317X2Y9"/>
    <dbReference type="GeneID" id="37110055"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="177"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY92989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="333" mass="37536" checksum="AF0912A1EF1BE050" modified="2018-10-10" version="1">MSLAPPVIDFTPFHAGSNQDRQRLVEEIRSACEELGFFQLRNHGISPDLQTDILEQSRDFFSLPVEIKEKYDRDNDGFNRGYERLRAQNFEKRAHGDLKEGFFLGRHLPLDDPDVQAGKFGQGPNKYPAEVTDPLRFRDTVDRYYGAVLNLAVNLMTVIAEMVGLDPEALDRFCDRPIATLRLLHYPPQPPDASELERGIGAHSDFGAITILLQDSIGGLQVWDRASNGWVDVVPVPGAVVVNTGNLMMRWTNDRYISNLHRVINRSGLDRYSIPFFFDGNADFLVECLESCRGPGQKAKYGPITVNDWMVGRYADTFGDDEKEGAKDPVDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4H3</accession>
    <name>A0A317X4H3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ZIP metal ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_364038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470006.1">
        <property type="nucleotide sequence ID" value="XM_025607188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4H3"/>
    <dbReference type="STRING" id="1450535.A0A317X4H3"/>
    <dbReference type="GeneID" id="37109331"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="470" mass="50051" checksum="50DEEED5ACA21A32" modified="2018-10-10" version="1">MAASNDLRGWVMSAVSGVACVLGSSVICADLILRRFSRRKSFQIVHNNAFLSASLSLSAGVMLFTSLYSMLPTSHRYLIRAGLSPSLAAYMLIGLFLAGVVVIRLASALLHRYIPSHVVDCAHTHEPHAGSDHEHGGKPDGHLHAHDSNHMSERTPLLTRSYKSSPATVTLPTSEDPSASMREESLRIRLTRRLSRLVVGVKPHCDENGPCFGFSQACGHECTKTLEGSEISVADDGTVRPPLPHPHSISGQIDSARPEDLEAGLPSSQCISHEASSSSSRTGLLDDHDAVSEDGTKLGNPQHHHHVPQNAFLSIGLQTSIAIALHKLPEGFITYATNHASPTLGLTVFLALFIHNISEGFAMALPLYLALHSRGWAMFWSSLLGGISQPAGAALAALWIWGARRANGDEATGPSWGVYGGMFAATAGVMVSVALQLFSEGLTLTHHRGMCTGFAIGGMVLMGLSFALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4X4</accession>
    <name>A0A317X4X4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470012.1">
        <property type="nucleotide sequence ID" value="XM_025611239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4X4"/>
    <dbReference type="GeneID" id="37113382"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="106" mass="12199" checksum="2ABF3FE5F35857C1" modified="2018-10-10" version="1">MCKTRKRKIRNKTKPNNTTHTLTHPHTHNLYHLPKPNPRTQPSTTGPKRKYQPAPEPKLKPHIDPSMLLTCIYPDTNPAGMRRNHASRWFGVQWSNAPAPDPRAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5G1</accession>
    <name>A0A317X5G1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_532747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470564.1">
        <property type="nucleotide sequence ID" value="XM_025611186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5G1"/>
    <dbReference type="STRING" id="1450535.A0A317X5G1"/>
    <dbReference type="GeneID" id="37113329"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12677">
        <property type="entry name" value="RRM4_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000704">
        <property type="entry name" value="Ribosome biogenesis (Nop4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000822">
        <property type="entry name" value="Ribosome biogenesis (Nop4), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034809">
        <property type="entry name" value="Nop4_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="156"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="314"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="499"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="645"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="738" mass="83591" checksum="D7BBE1D8C857B530" modified="2018-10-10" version="1">MAESKGSSPEATEARVNPIVEAAMESQNNKSTQEAPASNQPRRELFIRSLPASATTERLTEHFSQSYVIKHAIVVTDPETKLSKGYGFVTFADVEDAKAALEEFNGSVFEGKTIRVEYAQPRQRVVDENLRRSKPSAEALELKKQREDQRAATQPPKLIVRNLPWSIKEPDDLAVLFRSFGKVKFATLPKRGDKLAGFGFVVLRGKKNAEKALQAVNGKEIDGRTLAVDWAVEKNVWEDLQKGEEDQEQKEEEGSEDVDMADGNEEAEEAGSDEDLSAEGDDIEGDSDSDEDEDAEEDEDEEDEESKEDERDASTVFIRNLPFTCDDDMLYEHFTQFGPLRYARIVVDRETERPRGTGFACFWKSEDAASCVRDAPKQQENPAADKDKAKKVSTTYKHSVLQNENSDPSGRYTLEGRVLQVARAVSKTRAVQLEEEGVSRRLVRDTDKRRLYLLNEGTIPQNSPLYKKLSPSEIKMREDSFKQRQSFIKKNPTLHLSLTRLSIRNIPRHVTTKDLKQLARQAIVGFAEDVKKGLRQPLSKEELDRASEEMKEAEKLRKKKGVGVVRQAKIVFETRDGHKVGEESAAGRSRGYGFIEYYTHRHALMGLRWLNCHAVEVPANGSEEVKDKKKRLVVEFAIENAQVVKRRSEQHAKARTFKKGDQQGEEKSDKDGSKDKRFSKGFSKGPSKEPFKGQKRKRPDNNDKDAGGEDDEEQNKVAKRNRIIAKKRMQRRTRKGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5V9</accession>
    <name>A0A317X5V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_621458</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470755.1">
        <property type="nucleotide sequence ID" value="XM_025616999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5V9"/>
    <dbReference type="STRING" id="1450535.A0A317X5V9"/>
    <dbReference type="GeneID" id="37119142"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY93994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="77" mass="8828" checksum="4DB7F1F54F34FED6" modified="2018-10-10" version="1">MESPHEHQQALLLSRIIGNIEKLNESIMVMNRSLQEVNIQNMNVELVAQMFKNYQSNVLFHLEATENLKDPSTSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5Z3</accession>
    <name>A0A317X5Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_563554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470797.1">
        <property type="nucleotide sequence ID" value="XM_025614365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5Z3"/>
    <dbReference type="STRING" id="1450535.A0A317X5Z3"/>
    <dbReference type="GeneID" id="37116508"/>
    <dbReference type="OrthoDB" id="5333823at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="647" mass="73161" checksum="DAB2538AF34815DD" modified="2018-10-10" version="1">MGTGRNRRAPIPPLRCPPPFSPEVSSAHSRFQVSPPRSLLSRRSYPGGEQSIRFVASEGAPTQSSVPQRLSNMSSETGQMRRCGHSEAHPVCMRCQRSQNHCKYGPRFQWQDGLRAAGKCRGRTGIGSRKSSLQCKQSEEDSLSRSTRAEQKDRPDNDGESALILTPPSSHSPLRAATSNYVSNPTENSYRGRYYYWKESKAQSPGTSLQVLPWSIGVPDVDNVCLSFYESVMCNVAVTVDDEYTNPLRNTVMRMIFRSELTYYSVLMASAQYLRSFESRFDLLEMQVRQKVLGGLRRALTKSCLALEDVLLPTIFLCSSAVCVFMVKISHSCDATWVRHLTCFQLVIKQKIRGHTPTYVPQFFLSYFSAHLVLAKSLFPIDKALADVDVWGDPSSPVYAKGAPWTSSQVLSKVMRPETLHEINMWNGMSNQMLLLINDILSLKNDVQALQEQDTLLEGKRTAIEAKIITLHSSLRTTTHLLPESLRQFHDSAEGLHRCRLLEYTSEAYRLAACLLLSEASTPAFLGYTSSLELGFDSMRKQRHIDSTLSLIESIVYSLDYLPISWPLWALFIASCCCTSELEKTRALALFHAAQGKAPYENTIRAQTVVSLLWQRRELHEERERKRNGRFEWESVMEFLGWQTSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6C5</accession>
    <name>A0A317X6C5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane bound cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_582300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470636.1">
        <property type="nucleotide sequence ID" value="XM_025615468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6C5"/>
    <dbReference type="STRING" id="1450535.A0A317X6C5"/>
    <dbReference type="GeneID" id="37117611"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000016">
        <property type="entry name" value="Membrane bound cation transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="674"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="135"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="610"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="337"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="413"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="529"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="767" mass="82539" checksum="E88FE0383257178C" modified="2018-10-10" version="1">MEHGFRSVTENSAQRDMMTKGHLMFCLDRIHSWAKAHASTLSPQSQGPNQANESSEDASAQDGQVKEAIRDPASPESEKDAKEAPNRGLLVRMKDGTIRFTGHTKRALCHSWVNVLLVFVPVGIAAEAAGLNPGLIFAMNAIAIIPLAGLLSHATECVASRLGDTVGALINVTFGNAVELIILYHVSYCHAGTLLINTKHTGGSSIALVKNEIRIVQASLLGSILANLLLILGMAFLLGGLRFQEQASLLTVTQMSACLLSLSVMSLLLPTAFHASWSDETDADKYTLKVSRGTSVVLLLVYILYIVFQLKSHAYLYASIPQQIIDEESHPGILAEFMNSSSDSSSSSDESVDTTTSWSTAKRIKRAMKYRRHRKSSTSSRGTVSPQSFRKKSLADVPPTAVIDENAGSAADLSVTHQDGSGSFVIDFGDDTRYDADHEPQPRDFGTHNGAKASKEDRKAKRRERRKQEKRVEKEKGTTSVTNTTLTGRPSMKTHKSEPTVDRGQPPLPVEEAIEPAKRRSAFRPTMPSLLTNTVFSTTTPSNAAVPASPSNPYGLRRTHSLPSFTNRPPPPGSAVQFARGASRMPTGVTHTTAEVAPEQPEPEMSRTAAVVMLLVSTGLVAVCAEFLVDAIPTMVESSSVSEAFIGLIILPIVGNAAEHVTAVSVATKNKMDLAIGVSVGSSIQIAIFVTPLVVILGWCMDKDMSLYFTLFETICLFVTAFVVNFLVLDGRSNYLEGSLLIAAYVIISVAAFYYPDSGQSSTTAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6I0</accession>
    <name>A0A317X6I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FHA domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_322932</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470930.1">
        <property type="nucleotide sequence ID" value="XM_025606911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6I0"/>
    <dbReference type="STRING" id="1450535.A0A317X6I0"/>
    <dbReference type="GeneID" id="37109054"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000030">
        <property type="entry name" value="FHA domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="228"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="368"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="430"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="492"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="120"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="62225" checksum="738CA7E8872F9418" modified="2018-10-10" version="1">MSASVSASASSNLPSDVRSGPLRRLSQLRAYTQQHFSSSQPSSSSSSSGTRLSRRHTLSSRVSWFSPTSTGADSSQLSPVGSRTSGPCPESEPPSTLARYSSVLFPSYRGLEIDLRPSRQAETPSSSSNETSGIQTQGTMARPRGSSQALDARPDLEGSSQSASANLHAGALDSSDPVMSENPSSSSPRPKQKATIRFFPHQDSHQSSRPSLPFIPVSRTLPSDNCIIRVGRYSERDGLPVANPTDPSDAPVGFKSKVVSRKHCEFLYLNGQWHIKDVGSSSGTFLNHMRLSQPNMPSRLYTVKDGDIVQLGIDFRGGEEMIFRCVRIRIECNRSWQQQPNEFNKNTESLIKNLGKGDTADYSGCRECSICLGSVLRPYQCLFMAACAHVWHYKCVSRLIHTPDYPMFQCPNCRAYTDLSAEVDDTNDFDEEEAKQATPEDKRDSSDGSRSGTTSPQLEAEPVHTGDEPRQGSLPIEAGLAANIESMHLQEMDASEAARRPPPPTSNNDTVSSSVGNDVPGWQSLSQSPNALPTRQSLLRADTPVRSESSEDNPLTPLNDSGPLALDGRAAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6J9</accession>
    <name>A0A317X6J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Multicopper oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_554010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470960.1">
        <property type="nucleotide sequence ID" value="XM_025613688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6J9"/>
    <dbReference type="STRING" id="1450535.A0A317X6J9"/>
    <dbReference type="GeneID" id="37115831"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000071">
        <property type="entry name" value="Conidial pigment biosynthesis oxidase Abr1/brown 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000086">
        <property type="entry name" value="Multicopper oxidase abr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016364031" description="Multicopper oxidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="28"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="151"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="373"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY94199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="60680" checksum="A269AD397D976F6C" modified="2018-10-10" version="1">MIRTLLTLGLYGVVQQALGKNVYLDWNITWVIAAPDGYARPVIGINGQWPCPQIDVDVGDNLIVDVYNGLGNQSTGIHWHGLHQNYNGYMDGVPGVTQCELQPQQRMRYTVPMNQTGTYWYHSHEPGQYPDGLRGPIIVHDTVPAPFHYDEEMTITLSDWYHVQMPLLVEDFVVPGDHAPYGGQEPLPDSVLFNDMHNTRIKVKPSTTYLIHVVCMGNWAGHALVIDDHDMTIVRADGIEVEPHFLPPQYLRMTVGQRVDLLLTTKNDTSKNYAIWDGLDIDEMFVQESRSMPEGYNPNGTAWLMYNEDMPFPPAPEIHINNASLDFLDDVTLIPRDHLPLIDPIQHQFILDVYSTTVDGKPAYSINNMTYSAPDVPTLYTAMNADSEECMEPSLYGDVNPFVVNYGDVVEIVLNNHHDNLHPWHLHGHDFQVVQRTYPYGGYFNGYGNVSATPMRRDTIMVEPEGHFTAFLPADDDPISRVWMFHCHVEWHVEVRLMAIIIEAPDQLQNMTVPDDHLAICGNSQPSHWAPLPGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7G2</accession>
    <name>A0A317X7G2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_563169</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471317.1">
        <property type="nucleotide sequence ID" value="XM_025614339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7G2"/>
    <dbReference type="STRING" id="1450535.A0A317X7G2"/>
    <dbReference type="GeneID" id="37116482"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016379128" description="Phosphatidate phosphatase APP1 catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="3">
        <location>
            <begin position="279"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="500" mass="54588" checksum="537B5B348087221D" modified="2018-10-10" version="1">MRVSTSARQTLVQAALLSIVSAVPAPTAFVNDVAPPEPVITPSPVQNYPSRVAGRNILSDVDSDIHSVLSGLGSDLPSWVASGVPNYFQGFPTGDAVVSSLGLNSAELAALPTNVLNIDPYANWTSSGWNVRFHGNVYKQPNTSVSDLNKLANVFLGNTSISDLSQSEQDQARNLTAEILVVQQPHVPVNTIHLEPAPSQGSSGQPGGGGASNTTGGTQDLTLPYNTTVEGDFDTFVPIALNNLTAGNETSAIQRLNTYVEGATIGNSTAYLVPPTGLTIISDIDDILRVTKIYEPEQGLLNSFARPFRPWENMPDIYRNWSISVPNLHFHYLTTTPEQVTRNYMQFIYDTYPGGSFDTRPLNFSDVSATLSIRKYLLTKIFETFPQRKFILIADTSNSDIMRDYPEMATDFPGQVQCIWLRNTSATDSGDRFPYDTSGFKNLNQSNYMFFLHAEDLMNLDIANGECYNTSIPQNLTFGYQGLPLGLGDGTTAYKFGYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7Q2</accession>
    <name>A0A317X7Q2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GXWXG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_280619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471407.1">
        <property type="nucleotide sequence ID" value="XM_025606622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7Q2"/>
    <dbReference type="STRING" id="1450535.A0A317X7Q2"/>
    <dbReference type="GeneID" id="37108765"/>
    <dbReference type="OrthoDB" id="2213372at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.580">
        <property type="entry name" value="GXWXG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025951">
        <property type="entry name" value="GXWXG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14231">
        <property type="entry name" value="GXWXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXWXG" evidence="1">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="134" mass="14934" checksum="749467BF74FDBB41" modified="2018-10-10" version="1">MTRTPADEYVLLTNKDARLDPSEVDDIYSQLQPADPASLEGEWDMHVIDTGHPAQALAEDILPLMNTMDPDAGTGKIHEMKFHGAAGSLLVPEDQGMKQRFRYVDESTIAATNDYRPHYGDSGVLHFYLTRAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7Y5</accession>
    <name>A0A317X7Y5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_351324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470513.1">
        <property type="nucleotide sequence ID" value="XM_025607104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7Y5"/>
    <dbReference type="GeneID" id="37109247"/>
    <dbReference type="OrthoDB" id="3946700at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="431" mass="47006" checksum="AF21905C2694E6DC" modified="2018-10-10" version="1">MGIPLFCEASSTDASKNNPAKDSCAVARSAIRRQPTVRRASRYGSALRSATLRSPFPRPLVDEIEREASGLQRHVRSPLSNSSTADDPFDLTSGILDPGRRESGQRLLNDALRHGRPGQRLRIPRSSALPDLYRPSPGDDANNRSDLVHPPFTPRFAPAIAYHRTASPQMRADGARLSPFIRPDGFGGDISVAAAFPSLRRVGERSITEASRPNRESAVDGLGDRQRSLSPDDDHANDAWETLLTTITPDTNLPSADSSFTSASASGTNASTIGTARSSATSLQSMTNPLDSGAGTVQMVLDPYAEFLHPCDYPSSSDSDSDSESGISQQSLFRRYRRIRQMESLRRAQHLQSTMSNHPPIPTISFAFSDSSSTDPDLQQMQAILDRLARREDIPDEWWAAAGLSRTLGRRLGIPDDSNDTDSVDGRLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8F8</accession>
    <name>A0A317X8F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_484547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471242.1">
        <property type="nucleotide sequence ID" value="XM_025608962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8F8"/>
    <dbReference type="STRING" id="1450535.A0A317X8F8"/>
    <dbReference type="GeneID" id="37111105"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="10">
        <location>
            <begin position="237"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY94481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="565" mass="63663" checksum="F613A72F6E37B0F0" modified="2018-10-10" version="1">METNDIEWEAEEGIPHADDPFIQQYLRGRNSLILEEQKQRHDFNLSKALPPLAARACKIVSKIRDRELHQLYSPGSDERNAQLSMGMPIHPGVMSLDWNEVEKTDLWKIVKHMPKGSLLHAPFHAAIKPDFLNELAFSTPGICVYATRPLISQGDLNEAPFFFQYSSASTKDTEARPTIWSASYKLSSLIPISKAASSFPSGGETGFRTWLQSRFHSVAGCSDHHSRAMPLVNSLLSYEPILRACLYHVFSHLVGDGIRYAEFRTTFNFPYRKEGKDIPEDDYSEWCHVFQEELAKFQKTDEGRKLYGARIIWTSLRSLPKREIVESMKNCILAKYDYPDTICGFDIIGDKSNEKPLTDLVPILFWFRKECSAEGLEIPFFFHAGESLKTGGQADQGLFDAILLGSRRICQGLSLCQHPLAIEMVKEKKILIECSPISDEMLGLTDSIQTHPLPALLSRGVPVCLGASALGLSGGRTTGLTRQFWRAVQGLDSMGLTGLAMMVENSIRWSCYQDQPTAEWLSDLREGILGEGTRASRLQEWYADFESFCQWVTVEFAEAEVDEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9C7</accession>
    <name>A0A317X9C7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_531085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471937.1">
        <property type="nucleotide sequence ID" value="XM_025610823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9C7"/>
    <dbReference type="STRING" id="1450535.A0A317X9C7"/>
    <dbReference type="GeneID" id="37112966"/>
    <dbReference type="OrthoDB" id="10061782at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="1">
        <location>
            <begin position="52"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="224" mass="25347" checksum="262CBF2F11D4FA76" modified="2018-10-10" version="1">MWPFNEANYPAFFLFVYDAWVLHTVTPLVWRCSTKEVLLPLYQRNVDRHHCDIGCGSGYYLVHNTYTPESTITLLDIEPAPLSSTTTRLHQSHPTLPVHAHQHDILSPSPIPPPPPPSSLYDSISLTYLLHTLPASTATKASVFEKLKPAIAPSGVIFGATILGRGAWHSFLGRGFLRWLNWKWLDNYDDRPEVFVDALRENFKDVKCEIVGSVLIFEAREPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA25</accession>
    <name>A0A317XA25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MED5</name>
        <name evidence="11" type="ORF">BO94DRAFT_487230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA25"/>
    <dbReference type="STRING" id="1450535.A0A317XA25"/>
    <dbReference type="OrthoDB" id="5322661at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 10" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1020" mass="111985" checksum="A481C26760344948" modified="2018-10-10" version="1">MTSSEQWGTFLRQCLLHRIDATEFKSLTRLLLQRSPITEAPLLNVLLETRLATGIKWDPLLPLYIDCLCKMGVVQTSTVLNSLLKYSSIHDKPPTPGSEMAQSRQKRKCYTLMTDIRVVQDAMLSVSTGSAPKTFLEAIGIFNSIVDWVQAVVAWHNSHMDASHQTGGLMSSPDAVSLFESLGILLAALSGTAKGLQVLSADSHEALKIKLGQALSAYLPLCVEVSLPLRNRLDGLQKEFNLFGEPPSKALDVSMMENVNVNALQFEDSVMDGPMINSRAGLYVYINAMLVGRPLVDDSMLLNFLSNRYGGHYQVLIEEIITAAFDVLSNASYRSESSRSMFLLRSFLVNKLPAFIAAMLAASMVSLPMELCISHALSRLDPNTFPSFSQMFAMQGNTVLSDVRQEFLFACASHKLIPESSIERLLGENPMQTLPVGGPYHKDELVSQINTNPERAEQLINEIESMEGNAGAIVGAITDVMHHLCNQKETMTLKNICNSLSRRTQALDVILLFRSTKQILQPLCALLDAWHWDEDQGESQPVYDEFGSILLLVLTFKFRYDLRPHDMGIGGNNSFVLRLLENGFCSQKLDDLSEKQNKNLGAWINALFMAEGISEETMSTCSPQEFYLLVSTLFNQSLGACEAGKLEFDTLKGGFEYLLEPFLLPSLILALNWLGNHIWETESDPSIPLKTLQSLVNPSSISGEAKEIHRTVLNITARSLEEQLKGIRSRQPEDIKPILDALEPCLSFQRSGSCHRSELEPWTSHTPGGLLASIRSTFQSLLLWSTSPGMSMAPQTYTHRQLLAGIQIQGSARVLTTIIDELKLQTETGNGDVALDVAATIICAPLAESFAVDQNNHSHHPIDPSKEPLSRCPILTLRGALFIQHEHVPKISEKDPLRAEVIVRLYRRVNALMTPPSQVPNLDMNNIIQTMQLGVGGPGQMDLEQSGPGGHDDNINQMLDNAAAAAAAGMDGSQSMGGMGNMGLESTGGGLDTSIDDVLNAADMAVGNPEFLDLDMEGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA98</accession>
    <name>A0A317XA98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_553316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472190.1">
        <property type="nucleotide sequence ID" value="XM_025613650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA98"/>
    <dbReference type="STRING" id="1450535.A0A317XA98"/>
    <dbReference type="GeneID" id="37115793"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00775">
        <property type="entry name" value="UPF0311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020915">
        <property type="entry name" value="UPF0311"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37315:SF1">
        <property type="entry name" value="UPF0311 PROTEIN BLR7842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17760" checksum="E8FE357145E09BEB" modified="2018-10-10" version="1">METLLPPPNLVHLFTLTCTVSPPLEIGPGPYGRRRCIPITSGTVRGKYLSGEIVPGGADFMLVEENQTTHVNTNYVIKSHDGAYIYVRTEGTRSGPPDVLRALMESPDAVDPDQYWFHLHIKLETGHEKYRWMNNRVVVGRATRAKGEVAYDAYFLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAQ2</accession>
    <name>A0A317XAQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_542923</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471408.1">
        <property type="nucleotide sequence ID" value="XM_025613116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAQ2"/>
    <dbReference type="GeneID" id="37115259"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="252" mass="27833" checksum="BA34A7C421498799" modified="2018-10-10" version="1">MNLYSIPTTDGIWCGTTAAGIVKPVRFLLSFVIVVQAEVAGGAPPLQLPQNPQWHWPSTILLIGALKVLGRPLARPSVANFLAYYLSTEYRMICLTSFGCNFPHPKDTQSGLYWTARAGRDIGGSPGCLIQSIADIYQTARCKLFNPVAPPRCLCISQLPTSTNPQRFISHQDENMQHVEDTFQALILDVEIVHNSFPRLLTVYRQPLTSPQQSALTGLIHSPVVIKGASLLNSSQTFLPYFLWIDGITLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC96</accession>
    <name>A0A317XC96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_505189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472900.1">
        <property type="nucleotide sequence ID" value="XM_025609530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC96"/>
    <dbReference type="STRING" id="1450535.A0A317XC96"/>
    <dbReference type="GeneID" id="37111673"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF78">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="478" mass="54263" checksum="905C5DD986E8DC08" modified="2018-10-10" version="1">MLDGALLAGLFGNIVLYRLFFHRLRNVPGPVGARISRFYAAYQTFKHAQMHRHVQSLHQKYGDVVRIGPREVSICRPSAIRAIYGPPTRLAKGPWYDQVTHDNTKKTVFGIRDIKLHGQRRRVWDQGVKAINQYQIPLLEKSKLLMTKIREQQGRPMDITNWMTCLAFDVMGKVVLGTELGMLQTGQKTAELRQMDDSSRYATMAGTMPWLAPLLLQIPGLATVLNPFRHFCHTVLDEKRKTRTKGSEPTDVISWLIQANETGDPSAPPTDMALKDDAWVVIVAGSDTTATAMTNTIYYLATHPAVQTKLRQELDVLFPHGLTDWSYESVKDLKYLTYVINETLRLKPSAPDGLARVTPPQGLQVDELQIPGDVVVSVPTFTIQRDERYFDQADQFKPERWESIGNSANVPWIPFSRGVFDCVGKGIAWMEMRMALSMIVLEYDIDLADETQEFDGKELDNFLLELPALWATFRPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCC6</accession>
    <name>A0A317XCC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_620739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472028.1">
        <property type="nucleotide sequence ID" value="XM_025616953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCC6"/>
    <dbReference type="GeneID" id="37119096"/>
    <dbReference type="OrthoDB" id="4493161at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="340" mass="39191" checksum="E0A886888EE1AD83" modified="2018-10-10" version="1">MDSTAAYVNGDDEAIPLVKIEGPPEYQEHMKQLLADSKIRRSYDDEIHILSNDHSTPSYSSDKSEMIAALLHQVKEQAAQYLHRPINITAYSLPRGLDTVSWNHLCDSVFETNVTSMDYRLYRSDYLDAVRDAYRLDTCAGFSLPESCDLYLKSHSIFFIDIGREGLVNLWVGYVDEYVVRIYDGQHVVTAYEYDESEEKSGLYRFQQILWAFIEDNFTYDMTESFGAVVLSGEAPQEEMHAMKQAIYLALPEEWRPLLRAVIDPSYVAAIGIARRIEKHIDRPCFREEDLLKSYMIDPPDYDMIVEMLDYTEYMEGANDYYLPGDEEYPFTSTGGCELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCI8</accession>
    <name>A0A317XCI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_561834</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473087.1">
        <property type="nucleotide sequence ID" value="XM_025614246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCI8"/>
    <dbReference type="STRING" id="1450535.A0A317XCI8"/>
    <dbReference type="GeneID" id="37116389"/>
    <dbReference type="OrthoDB" id="26203at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053247">
        <property type="entry name" value="GPCR_GPR1/git3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058:SF1">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 2 PROFILE 2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42058">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="59"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="493" mass="54819" checksum="3B2612C00E99CA54" modified="2018-10-10" version="1">MANHTLSGYCPTPFLQESLFSSTGGFIDGRFCEELTTEHGKVSCCLPCPMAEWVYGDDLTSQTKVASWLGVATLPLCIFLLISFAVLPAKWTHRHYLSICFTLGICCMELAFIIPLGVNPEQCHDPITPNDMHTDLSCAFTGSLLLFGGWVSVVFSFIRTLAFHLQVCWEIVLGTKFMWGALILGWGIPIVGLTEMLILTGVSYRFGIVCHINVHDSNKDYWAPVLGFAAAALILQFVTMLYCVYVYVKSVYDQGTSTTSSGLPSYSTSVRTLTARQAYRRIRRVFELQWRGVTLVLVIVTNVIFFSVVFIRMDNHLTATAANLDRGAPWLACLVLTQGDKSQCFSEASNLLPNKATLLAVLILLATVGFWNFVLYARPSIFLGWADLFKSQVREPHEFVSADARRTPDPRTYEMISGSSLPPYKTPEAVVRSPSPVRMKSPDGAQHYGRQARYTRPSMSFSSPRPPSSLQGHERDWDPEATFAPSHSQKGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD81</accession>
    <name>A0A317XD81_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_454021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473046.1">
        <property type="nucleotide sequence ID" value="XM_025607590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD81"/>
    <dbReference type="STRING" id="1450535.A0A317XD81"/>
    <dbReference type="GeneID" id="37109733"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000190">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000276">
        <property type="entry name" value="Sugar transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="38"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="481" mass="52557" checksum="1D5BDE6B9A207C99" modified="2018-10-10" version="1">MGLGKYLLTRVPTLVPPMNPAPNPFTALSLLSRKQWLFFGVAFFGWTWDAFDFFTVSLTTTQLAKTFDKTVTDITWGITLVLMLRSVGAITFGIAADRWGRKWPFIVNNLLFIVLELGTGFCQTYRQFLGCRALFGIAMGGLYGNAAATALEDCPMEARGLVSGLLQQGYAFGYLLATAFARGLVDTTPHGWRPLYWFGACPPVLIIIYRLCLPETDAFLERQATRENFHGGVTATFMSEGKTAIKRHWLLLVYLVLLMAGFNFMSHGSQDLYPTMLENQFNFSANAVTVTQVVANLGALSGGTLCGWASQIFGRRFSIIVMAVIGGALLYPYTFVTSTNVMAAAFFEQFCVQGAWGVIPIHLMELSPGSIRTFAVGTAYQLGNLVSSASSTIESTIGERFPLPPTDEGTKRYQYGKVICIFMGCVYGYTILVTLLGPERLGRQFDVAHDADMAAVAAHRGTVADGAESDPEKGTARTLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDA6</accession>
    <name>A0A317XDA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_453140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473367.1">
        <property type="nucleotide sequence ID" value="XM_025607553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDA6"/>
    <dbReference type="GeneID" id="37109696"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY96606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="433" mass="48019" checksum="A8CBB34020834B4C" modified="2018-10-10" version="1">MKYKSPQVEEYPDTPDAPKRKLDQRDSETATGEGSLEAENEQPPSKASKSSGKAAAEEDDVIQENDEEFEDEELEDDIEEEEGDEGLPEDEDAEGEEDYEGEEKEEDASSKPKLEKVVDEFGRTPLHGTAIAEGHLESSPETLLAMAIDAMLKSRPISHDLSERAVKKVIEVGYHDIQKLGESSWEERTMVLKDGGYNRYREQGATNLGDLAELITEKYDGDLNNLLKKAHNDRDETRQLIKEIKGLGDLGADLFFNNVQSVWPSMAPFMDGRSLQTADKAGISTDLDAIYADLGHDSTRMSRLANGFRIVNIAVGVLMVLGGIAQFFPASMSTIIVGVYVIIFGTIVGGLEFLPNVPDYVYRYASFLFSFLGRGAFYIFVGSIMLHDHWFRYIAGSIIGFIGLGYLALEFIPSIEPPSNMREADQSWGAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDM4</accession>
    <name>A0A317XDM4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glial factor naturation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_529995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473374.1">
        <property type="nucleotide sequence ID" value="XM_025610578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDM4"/>
    <dbReference type="STRING" id="1450535.A0A317XDM4"/>
    <dbReference type="GeneID" id="37112721"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11283">
        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000048">
        <property type="entry name" value="Putative gmf family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY96613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="141" mass="16253" checksum="ACFFF233E1ECACCB" modified="2018-10-10" version="1">MSESRLYSFSPETKEKLRKFRLGTSRAKDPQAIIYVIDNKSQEIRPEDGEVYTKMVDLADELPESSPRFILLSYPLTLASGRLTVPYVLLYYLPENCNPSMRMMYAGAVELMRNTAEVNRVIEVYEEDDIISIESKLQSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE78</accession>
    <name>A0A317XE78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_620372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472823.1">
        <property type="nucleotide sequence ID" value="XM_025616927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE78"/>
    <dbReference type="STRING" id="1450535.A0A317XE78"/>
    <dbReference type="GeneID" id="37119070"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20681" checksum="0E23CFC30A21307C" modified="2018-10-10" version="1">MKVVFQYLQTKQVQGVHVMIGALMETLFSPFFGMYDSTTVSLSYWGTGDEVWESTTYGNAADFVASVALDPTAVGSWVIGSVKQIAQIYEDVYGERPILTKLGSLDDLDGLIQERRQKDPPNVMSYLVLSYNYYCMNGQTAVLPETEKPALFEIRRESFEVFFRQQKKESIPTAIARVGTSLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XET1</accession>
    <name>A0A317XET1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_6131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473083.1">
        <property type="nucleotide sequence ID" value="XM_025616695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XET1"/>
    <dbReference type="GeneID" id="37118838"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="88" mass="9430" checksum="EF09A9AD0FD96BB6" modified="2018-10-10" version="1">MVKVWPSLALSFSRLFSRTAVPLQPPSSFLVPGLCSPFVSPDSSLSALVLGPSRFLGRFRASLSLADLDLLTSLSLPLPSRVLLSAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UUH0</accession>
    <name>A0A317UUH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_570447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000064">
        <property type="protein sequence ID" value="PWY65019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461370.1">
        <property type="nucleotide sequence ID" value="XM_025614811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UUH0"/>
    <dbReference type="STRING" id="1450535.A0A317UUH0"/>
    <dbReference type="GeneID" id="37116954"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000014">
        <property type="entry name" value="Translation machinery-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="8">
        <location>
            <begin position="102"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY65019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="196" mass="21591" checksum="A7D7C069518CD8BA" modified="2018-10-10" version="1">MAEVVQPVSAESQAKHVLYCGVCTLPPEYCEFGGTAKKCEDWLKDSHPDMYQQLYSEEALSTNLATLSVSARERAAKDAAKKEAKAAAAEARDAERKAVSKVQIKRVERNKRKHVTVVTGLDIYGLENKKVAKDLGKKFATGSSMTRSAGGTEEITVQGDVSEEIKEWLLEAYGKEIPEANIELIEDKKKKKAAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWS9</accession>
    <name>A0A317UWS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_528595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461672.1">
        <property type="nucleotide sequence ID" value="XM_025610428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UWS9"/>
    <dbReference type="STRING" id="1450535.A0A317UWS9"/>
    <dbReference type="GeneID" id="37112571"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="57"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY66474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="361" mass="40975" checksum="EC8CA110C66D5B7A" modified="2018-10-10" version="1">MSTPQLTRTTLRKTLSSLLHQPSTCTITRPLTTHARAPTTYTLNTGAQIPALGFGTFQDPNSQESTVSLALQRGMRLIDTARVYNVEKQVGQGIKKSGIPREDIFLGTKLWCNDYHPEDVERAVDDSLRDLDTPYVDLLLMHYPCTFKRGEERFPRDGQGRMIHGETTFVDTWRAMERVVKRTGKVRAIGVSNFSKAEVEMLIRESDTVPAVHQMEVHPYLQQKGFNEWLHGQGIHVVQFSPLGNMNDFYRQTGWSKEIAHMMRVIDQPVLKEIGEKYGKSPVQVALAWGINSGRSVIPKSVIDWQIEENLAADFELMPEDMARIATLDAKARFNDPSLDYEWRLYGDLEGIDGTVRGRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0N6</accession>
    <name>A0A317V0N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_479529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461626.1">
        <property type="nucleotide sequence ID" value="XM_025608748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0N6"/>
    <dbReference type="STRING" id="1450535.A0A317V0N6"/>
    <dbReference type="GeneID" id="37110891"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF6">
        <property type="entry name" value="OXIDASE USTYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23313" checksum="C3D5BFF1DA67BD00" modified="2018-10-10" version="1" fragment="single">AGLTRTVPLAWGPNDALNDTEQDALWDATSYDLGNIALSDDFARAVGLPRAQRFPWDNDKGIYLINGYHNLHCVKTLRTALVEFRDARPQSSPWAHVQHCLLVLRDEIMCDADDTPRYTGFQPNQKSGLGQVRMCRDFRQLERWALEQTACWRHIGEIREEGFRELDRYRFCPEGSPYKEMSETMWLKGDWWRKYKDGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2N2</accession>
    <name>A0A317V2N2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_527679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462196.1">
        <property type="nucleotide sequence ID" value="XM_025610396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2N2"/>
    <dbReference type="STRING" id="1450535.A0A317V2N2"/>
    <dbReference type="GeneID" id="37112539"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496">
        <property type="entry name" value="FERREDOXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21496:SF0">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="57"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY68533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="168" mass="18781" checksum="6F4427EFE19E45C0" modified="2018-10-10" version="1">MFPFFSRQSTSKKGWVRIGLLSDFPDVESKPDGTCRVTPSCKAFTIPNTTTTTTTPPEPITADIDIPGDMKDQVLVFRYKGKVHAVDHQCPHSSFPLSQGNLFDIEDFGVVLSAGITCPKHDWSFDLFSGQGDRGNYKLKIWEVDVREGSGEAEGDKEVWVRRKQRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VB88</accession>
    <name>A0A317VB88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_590492</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462395.1">
        <property type="nucleotide sequence ID" value="XM_025616031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VB88"/>
    <dbReference type="STRING" id="1450535.A0A317VB88"/>
    <dbReference type="GeneID" id="37118174"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000017">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="210"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="238"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY69190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="539" mass="59719" checksum="A5944F5948D4CF02" modified="2018-10-10" version="1">MADQEVPHATFDTILILDFGSQYTHLLTRRLREINVYSEMLPCTQKVADLPFKPKGIILSGGPYSVYEDGAPHVDPAVFDLGVPILGICYGLQEIAYRLSKDNVSAGTAREYGHADLHAKKLDDQGHVDKLFAGLEGQIKVWMSHGDKLVKLPEGFHTIATTSNSEYAGIAHMSKPLYGVQFHPEVTHTPLGATILKNFAVDICDAQQNWTMSRFVDQEISRIRKLVGETDHVLGAVSGGVDSTVAAKLMKEAIGDRFHAVLVNNGCMRLNECDIVEETLNKHLGINLTVVDASKRFLDGLKGVTEPEKKRKFIGNTFIDVFEEEALKIEAKAEHEGAKIKWFLQGTLYPDVIESISFKGPSATIKTHHNVGGLPQRMIDGQGMKLIEPLRELFKDEVRALGRQLGIAHELVMRHPFPGPGIAIRVLGEVTPERVEIARKADHIFISMIREAGLYDQIAQAYAALDPSKAVGVMGDKRVYAEIIILRAVETTDFMTARAFPFDNEFLSRCSTRIINEVHGVSRVLYDISSKPPATIEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCR1</accession>
    <name>A0A317VCR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_569142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463106.1">
        <property type="nucleotide sequence ID" value="XM_025614722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCR1"/>
    <dbReference type="STRING" id="1450535.A0A317VCR1"/>
    <dbReference type="GeneID" id="37116865"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY72153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="449" mass="51696" checksum="3D5350FA6DFEC665" modified="2018-10-10" version="1">MTTLPLLRGNNVSLDDALADDDNILHRLDYPRKQKDFWSHLISLKAEIEIRYNVCIPICINPPSENHVLVRIPLPYKIGEEIKPGNVDEKLRCEAATYIWIRQNCPNVPIPSLHGFAFPDGQTFVEPACVSLFSRLRWRINWVVRSWLGFPTSCPYVGLQRLGALRTGSMIIGYIKSGRMLSDSWGLHLQDTIRRKTLFNDLANIILSLNRTQLPRIGSLTVSNDGIISLTNRPLTLRLQTFENEGIPTIPYNSTYQSPNAIHDVKDGQERLAALTMMRGLLHQFISRQYRHGPFVLTLTDLHPSNIFVDEDWHITSLIDLEWACAFPVELQAPPYWLTGRPIDDIERGEDLETFEKVVIEFMEALDEQEKVSQRSNVSHAQIVRSCWDRGSFCPKGLLRVFNEHIQSRFSEEHCTQSIFDRTVTDSLIEKKLKEEESYKDGLRKRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFN1</accession>
    <name>A0A317VFN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_589817</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463192.1">
        <property type="nucleotide sequence ID" value="XM_025615970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFN1"/>
    <dbReference type="STRING" id="1450535.A0A317VFN1"/>
    <dbReference type="GeneID" id="37118113"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="125"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="7">
        <location>
            <begin position="336"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY72239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="550" mass="60376" checksum="CB57EFB1FFD6DACD" modified="2018-10-10" version="1">MAERYIPEHRRTQFKARNQFRPDELRRRREEQQVEIRKQKREENLAKRRGIQTRDGGIGVGGGVAAAESDDEASAIESELSVELPEMVKGVFSDQIDQQIQATTKFRKLLSKERNPPIERVIETGVVSRFVEFLRSPHTLVQFEAAWALTNIASGSAQQTQVVIEAGAVPIFVELLSSPEPDVREQAVWALGNIAGDSPQCRDFVLNAGALRPLLNLINDGRKLSMLRNATWTLSNFCRGKTPQPDWNNIAPALPVLAKLIYMLDDEVLIDACWAISYLSDGANDKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDVQTQVIINCGALPALLALLSSTKDGIRKEACWTISNITAGNSSQIQAVVDAGIIPPLINLLANGDFKTRKEACWAISNATSGGLQKPEQIRYLVSQGCIKPLCDLLACPDNKIIQVALDGLENILKVGDMDKEAAQSGEARVNRYALFIEEAGGMEKIHDCQNNANEEIYMKAYNIIEKYFSDEDEAGDIDEVAPQQTQTGFALGTTQQQGGFNFANGGDSMDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGU7</accession>
    <name>A0A317VGU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_539288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463115.1">
        <property type="nucleotide sequence ID" value="XM_025612675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGU7"/>
    <dbReference type="STRING" id="1450535.A0A317VGU7"/>
    <dbReference type="GeneID" id="37114818"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY72162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="266" mass="28369" checksum="EB2CAC38821FD681" modified="2018-10-10" version="1">MPIPVPSASSLHDLFSLKGKVVVVTGASGPRGMGIEAARGCAEMGANVALTYSSRPEGGEKNAAEIAETYGVKAKAYKCNVGDWNSVKKLVDDVLAEFGQIDAFIANAGKTANSGILDGSVEDWEEVIQTDLTGTFHCAKAVGPHFKQRGKGSFIITSSMSGHIANFPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSISPGYIDTGLSDFVDKKVQDLWMSMIPMGRNGDAKELKGAYVYLASDASTYTTGHDLVIDGGYTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHJ2</accession>
    <name>A0A317VHJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">SLX4</name>
        <name evidence="11" type="ORF">BO94DRAFT_538825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="9">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SLX4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHJ2"/>
    <dbReference type="STRING" id="1450535.A0A317VHJ2"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22999">
        <property type="entry name" value="SAP_SLX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="13"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="248"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="473"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="593"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="723"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="514"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="628"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="731"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY73783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="848" mass="92266" checksum="898FA9C08F04FF70" modified="2018-10-10" version="1">MAITTEVLILSSSPEHNPVRTPAPPAYNPEKLFGLSPIDTSTTPLQSPSELFQPPTHSRFFKIKKQVDGPYQKKVNKTPNTSTNDESAVLAIDGEPVAEKPKRRGRPRKELTKAPGESEPIVAGKKKDASKKSTTGAPKKRETTTKRSTPANRTISGRIAKAGSSQPKGAKEQDNCPSTPRASSAPKATEALEWDDDGLQLEQAMARRLDWTPTQNKTKQIIELDGRPGSDDNGSGFGNLLSEYGFNGATAPASDYVASEDGGPTKRRRIELVDPGVYPAPKQSAINIDGKNNTGNEPHNPTSAAQKKPKKRATKFTTLTARVTAKYLNESAESSDIVDEGTTTVEGNSTTKPRGSRSKKKGQQSSKSRGPEFVVLSPEEAAKSLEDQELIFGTCSQLEREDSPITIRELQAAIHESEQSMMSEVNGRPYQGLSKGTSSAVSRFTGSGNLWSVASRDVDGSLMQVEVVDLLDSPDRSDPVALGEHLSKDRTDTATECNGSPSNPIQKDIGEPEATSTVCDEPSTLPTQPTQTGNKSTENTTSQAPKPRPRMPQYSDFTDAQLSKQIAKYGFKPIKGRKRMIELLQKCWEAKNGISSQPNDENPQQHPPADKVSEAVPSPSKPNHRTTGKNTARKTNTNSRGKAQSRTPSTITEDAPSAMAVNSKKTTSLPPSTSLSNTPKPKPTQTPSKTPKYSFADVEEIEDSEDEAVPSPSRLQNRLLQHTTTIPKPSLPTSHLPSSPSRLTSRTNSTHITTTSTENNPLPNLSDQITKAIRAQPRLTAPRPGPTWHEKILMYDPIPLEEFTTWLNTEGLSLINEDREVGAGFVRRWCESKGICCCYRPKKKDDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHZ2</accession>
    <name>A0A317VHZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_246042</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463276.1">
        <property type="nucleotide sequence ID" value="XM_025606408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHZ2"/>
    <dbReference type="STRING" id="1450535.A0A317VHZ2"/>
    <dbReference type="GeneID" id="37108551"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016277812" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY72502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="229" mass="22863" checksum="52E3536409108812" modified="2018-10-10" version="1">MRSMFYFALSALATLATAAQNPFNVPDGGYEFEAGSPTTLIWDPTTSGSVTLRLQWGAVFTTTTGDLIAGSIDNSGNYTWTPSASLASRSDYTVEIIDDDDTSIVNYTPRFSIAGTTGSVTTSVASSTTTSAASSTSSSSGQSTTISATTLSTATSSTSSSTSSASSSTTDSASTASASSSKTASSSSSLTASSSSSSATTTTLSTNAGMVNRVSIGMMALVLGAVALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJY4</accession>
    <name>A0A317VJY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_538761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463789.1">
        <property type="nucleotide sequence ID" value="XM_025612554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJY4"/>
    <dbReference type="STRING" id="1450535.A0A317VJY4"/>
    <dbReference type="GeneID" id="37114697"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="7"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY74596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="274" mass="29771" checksum="39C167D847F910EE" modified="2018-10-10" version="1">MQVLLLGGHGKVALHLTPLLLARSWNVTSVIRNAEHENEIVALGKGTRGKLNVLLSSLDDVKSDADAKKILDSVSPDYVVWSAGAGGKGGPERTFAIDERAAKHFLSASFAHPTVTKFLLVSWLGSRRVQPTWIADDEWSGLQNVFYNVLPAYAKAKLEADEYMTALAAQRKKLVAAGAARPLQAINLRPGTLTDTSATRKVDLGKTKKGMGKVTREDVAIVADQLLARDDTDGWYDLLEGEEPVDQAVERVAREKIDAVDGENVEGMVKRFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKM7</accession>
    <name>A0A317VKM7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BO94DRAFT_569061</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463264.1">
        <property type="nucleotide sequence ID" value="XM_025614718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKM7"/>
    <dbReference type="STRING" id="1450535.A0A317VKM7"/>
    <dbReference type="GeneID" id="37116861"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="22">
        <location>
            <begin position="22"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="23">
        <location>
            <begin position="537"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="719"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PWY72490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="742" mass="83225" checksum="70FF75A2101FE6A5" modified="2018-10-10" version="1">MAESPLDVLLKGNSGRTTRGLLRFIILATIAAAAVSSRLFSVIRFESIIHEFDPWFNFRATKYLVQHGFESFWDWFDDRTWHPLGRVTGGTLYPGLMVTSGVIYHVLRFLTIPVDIRNICVLLAPGFSGLTALAMYFLTCEMATSPSAGLLAAAFMGIVPGYISRSVAGSYDNEAIAIFLLVFTFFLWIKAVKNGSIMWGALAALFYGYMVSAWGGYVFITNLIPLHVFVLLCMGRYSSRIYISYTTWYALGTLASMQIPFVGFLPIRNSDHMSALGVFGLIQLVAFADFVRGFIPGKHFQRLLTTMIIVVFGVAFIGLVVLTVSGVIAPWSGRFYSLWDTGYAKIHIPIIASVSEHQPTAWPAFFFDLNFLIWLFPAGVYMCFRDLKDEHVFVIIYSVLASYFAGVMVRLMLTLTPIVCVAAALALSTILDTYVFATNGPNPRAKANEDTSSEGLRSARKPDVGITSYLSKAVVTSSVVVYLLLFVAHCTWVTSNAYSSPSVVLASRMPDGSQHIIDDYREAYYWLRQNTAHNAKIMSWWDYGYQIGGMADRPTLVDNNTWNNTHIATVGKAMSSREEVSYPILRQHDVDYVLVVFGGLLGYSGDDINKFLWMVRIAEGIWPDEVKERDFFTARGEYRVDDGATPTMRNSLMYKMSYYNFNSLFQPGQAVDRVRGSRLPAEGPQLSTLEEAFTSENWIIRIYKVKDLDNLGRDHNTAVAFDKGNKRKRATKRKGPRVLRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLM6</accession>
    <name>A0A317VLM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Farnesyl pyrophosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_524160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463900.1">
        <property type="nucleotide sequence ID" value="XM_025610247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLM6"/>
    <dbReference type="STRING" id="1450535.A0A317VLM6"/>
    <dbReference type="GeneID" id="37112390"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY75273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="354" mass="39722" checksum="AE4463B59AC5C358" modified="2018-10-10" version="1">MDINPDRFESIFPTVLEDALSYAKSIHTPPEALSWLRKNITHNTTSGKHLRGLLIPNTYARTLSRPLTSPEYTLAAKLGWLVEFLQASFLVPDDIEDHDTFRRGKPSWHAIPGVGLKAINDAALLQSIVYSLLKRYLKGKSGWYVDVVELFQEVVFRTELGQMVDLVSVTSRSSRGRDGKGGVHGLTKGKCETIARMKTAYYSVYAPVAVGLYLGGVATGENLERMRGIAVRLGMYYQVQDDYLDSFGERGRLGKEVGRDIKDGKCSWLIVEALKMVDAGQRAVLEEWYGQGEGEGVERVQGVFREVGMERAFREFEEGVIGEVRRDVEGIDESSGLRKGIFVDIIDIMYRRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VML6</accession>
    <name>A0A317VML6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_499895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463664.1">
        <property type="nucleotide sequence ID" value="XM_025609398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VML6"/>
    <dbReference type="STRING" id="1450535.A0A317VML6"/>
    <dbReference type="GeneID" id="37111541"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="24"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY74471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="541" mass="60975" checksum="8A17C98FAF3D7C4C" modified="2018-10-10" version="1" fragment="single">MRLLYADGPGIRLTEFADVPTTDYAILSHTWEQEEVTFQDMISNNATAKQGFLKIKGCCETASEQGIKYSWVDTCCIDKASSAELSEAINSMYRWYQEAQICYVYLADVNSKSDIIRSKWFTRGWTLQELIAPRNIEFLNKCWKKLGTKETLQDLLTKITRIPPGVLSGEEDIENVSVAQRMSWAAPRVTTRVEDRAYSLLGIFGINMPLIYGEGKRSFARLQEEILKVVDDQSIFAWRSDDENHGGLLATSPDAFRESAGIISTNLFSSSAGPLTQSSKGIHLELRLIATDHPGQGLAILNCVDQARESHPLAIHLKDWLMTMEQFERVQCSELEYVNLRELKHSQYPLRRICIKQRRHVTPKQHRPSKDISVLNTTSHWLNSIHNLVLNSADENRKILGSLAASGDVELLWRLLTQSDFDPERKNNRGRTLLSEAVEYGHLPIIKLLLARSGVQLDSNDESHRMPLSHTASAGHVPIIELLLETSKVSIESRDKEGFTPLAWAVKDNQSEAVQLLLEKGAYIDSKDDGNQTPLASAIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNZ2</accession>
    <name>A0A317VNZ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_559613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463946.1">
        <property type="nucleotide sequence ID" value="XM_025614084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNZ2"/>
    <dbReference type="STRING" id="1450535.A0A317VNZ2"/>
    <dbReference type="GeneID" id="37116227"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="114"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY75319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="647" mass="73508" checksum="18E3950761D5EEAB" modified="2018-10-10" version="1">MSTAKKTHTTPADQEKLQAIVAVKGVKNELKKLFRESPTVGLDEKTRRELEGDGDLPPLPFPITSPELRGPSEKITAAIIGAGAAGLFTGMIFDYLRRKAALDVSYEIIEAARENRVGGRLYTHHFGSADRLDYYDVGAMRFPDNPVMSRVFKLFNRLRMERTEDIAAAQNGMLIPYYMQNDAGDEPWRFNSITEWGNLQGIQVQARHAGPFNLNTDGKIDVRLLNFTPDVVMNEAIHNIREALKREDDQGWQLLMHYDSMSTRDFLRRVYQSHVRRLDIPPPPYNFETIEWMETFNGGTSWYDQAHSETVLESLDFHYDDNTSWWCVRGSSQIIAKRMQEALEISPRWTLNTSIQKIKKQKETKTYSGVFSSVPLGCPQRMETKDANLNYGTKQAIRSLGYGESANVGMTFERAWWIHDLGEHNITMGGLGHSDLMIRTCVYPSYNYNLGRNEPAALLCSYTWQQDAQRISSLIHGDKAKEEDLKEQIVRDLACLHSTTPDSEENLYNLIKRLYVDHHAFDWGHDPNAMGSFAFFRPQQFSSMWPHIIQPSGDLVIIGEAASPRHAWVVGALDSAVHGVHDWLVANQNAIPHASEAISVLRTEEAGEDNPFVGLPSFMSSNLAEWHAQRTSPESFSRNQIKHILLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VP40</accession>
    <name>A0A317VP40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464120.1">
        <property type="nucleotide sequence ID" value="XM_025612503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VP40"/>
    <dbReference type="STRING" id="1450535.A0A317VP40"/>
    <dbReference type="GeneID" id="37114646"/>
    <dbReference type="OrthoDB" id="3660930at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016264858" evidence="1">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="84" mass="9292" checksum="4160A03BDBF6DD89" modified="2018-10-10" version="1">MKVLPYLLVGAYATTALAIVYPNAEAEAQAEAECGSLGLMRVDPADLPEGVTLADVRKCREHPLGYLSTPGAFDYRRYLPRWMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPK5</accession>
    <name>A0A317VPK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_209709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463828.1">
        <property type="nucleotide sequence ID" value="XM_025606149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPK5"/>
    <dbReference type="STRING" id="1450535.A0A317VPK5"/>
    <dbReference type="GeneID" id="37108292"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY75201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16297" checksum="9613AB31FDA3EBC9" modified="2018-10-10" version="1">MGKTNWLMRPKFCAVVQKWRRDSLASVVDHSVNDPFRSRAISAKFITQLFHVRQARQLLEGTGTQLQTFIGLLHGSDHTAVSVLQAQLALVDTAQELDMIINLGTLLSRNIAYVELDILHSGQLRGHGRGWHRGFGRVMLLFPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPL4</accession>
    <name>A0A317VPL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_577946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463838.1">
        <property type="nucleotide sequence ID" value="XM_025615195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPL4"/>
    <dbReference type="STRING" id="1450535.A0A317VPL4"/>
    <dbReference type="GeneID" id="37117338"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY75211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="531" mass="58467" checksum="7172BD2FDD376474" modified="2018-10-10" version="1">MADKKIDIDYLEHVEQVLVDETGRIQRLPVPSDDPNDPLNLALWEKTGIVVCCCWFSIMSLSVIGGLGSVLDVFFQMYGAEGHSTNQVVWLSTFPSLFVGIGNYIILPLALICGRRPVMLIANTVLLGSLVGCALSQNWEQHFGLRILLGFATGATESLLPLILAEVTFIHQRGTIYGIYWATQNIVTSLLTLASSYEVAALGWRWFYWVFVITVAVGLVVVLFSCFETRFQRRAVIIDDHVVVTDQYGVTRVLNAEETQEYLSREDHPGPNFGEETPPKKSYRQMLSLWPGLSPRPLRTILLTWWQMLETFSSPGIIYATLLSAVILGGSVGVSLTYNTVLQYNYGWDAASIGLINLGGVFGGLGGMLYAGIFGDRFIVWMAQRSEGVHKPEHHLLLLIGPGLLAVASLILYGFTADGNATWGGPFMGWTLYQVSFVSTLIRTTSFATEAWEKNPGPALVTVVGTKNLIGFGVSYGLNPMVAKYSYPAAMGILAGVVGGVLLLGIPVYFLNPMWRRYISQQRTRGVEQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPW0</accession>
    <name>A0A317VPW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit J</fullName>
            <shortName evidence="5">eIF3j</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 30 kDa subunit homolog</fullName>
            <shortName evidence="5">eIF-3 30 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">HCR1</name>
        <name evidence="7" type="ORF">BO94DRAFT_538253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit J family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPW0"/>
    <dbReference type="STRING" id="1450535.A0A317VPW0"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.60:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03009">
        <property type="entry name" value="eIF3j"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY76386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="269" mass="30102" checksum="459A4C6569401376" modified="2018-10-10" version="1">MAPSKWDEEEEESVSPPPIAPRRKFDDEEEEEDVLDSWDAAEDSEVEREKAAKAAEAKAKAEAEAAANKKSKAQRIQEHKATRKAQADADSDEDSDEDEAERRARLRKTEKDSDLKHAEDLFGDIDMNRMRNRTAAPKAVVISDSADPTQAIDLSAMPLFKPATKDQFTRVTTTLIPLLTTQSKKPQFALWAQEFVKQLVKDLPSGDVKKIASSLTTLSNEKMKEERAADKGNKKTKAAKTKVSLVTSRENRIETNSYDDDGLDDDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQH5</accession>
    <name>A0A317VQH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_605706</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463924.1">
        <property type="nucleotide sequence ID" value="XM_025616505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQH5"/>
    <dbReference type="STRING" id="1450535.A0A317VQH5"/>
    <dbReference type="GeneID" id="37118648"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AUSG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY75297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="516" mass="58453" checksum="4D7C85E4C8E6F936" modified="2018-10-10" version="1">MDTSHRFYSDGNVGGVILGIIVITFLVLRIRERLWNPSKMPVFNDRKWFEFGYGNAKNRYVADPEGLIRHGLKHGGDAFYLYTDANFCLILSPKYADMIRNDDRLDLGEFLADDFHLGIPGFEPFSNIALSSKIIQTTVKTKLARQTANLVTPLSKEASIALHNNWGEETAEWHQAKLKRSISNFVGQLSSRGFLGDEDLCRDSAWLDLAFDLLEESFIAAHILRLWPTPLRRLARWLIPSYRKAMVLLQEATKYIQPLLDRKNGSASVKGGSLEKDGSLTTALDWLEDASKGSAENMTSLLFTLSLAALDTSTDLLSKVMCDLSEHPNLVDDLRREIIEVLGKEKMTRSSLQRLFLLDSVMKESQRIRPLGLVGMLRRAKEKVVLPDGLIIPKATPVMVSTLHMMDSTVWADGDKYDGYRFFNLRKEANDSLSSRYQFTTTSPDHLGFGHGRQACPGRHYAATFGKIILCHIIMKYDFNVLLPEEGVIELRGHNMLPSPKIKINIRRRKEEISFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQP4</accession>
    <name>A0A317VQP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_605540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463839.1">
        <property type="nucleotide sequence ID" value="XM_025616494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQP4"/>
    <dbReference type="STRING" id="1450535.A0A317VQP4"/>
    <dbReference type="GeneID" id="37118637"/>
    <dbReference type="OrthoDB" id="2998174at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY75212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="295" mass="34154" checksum="F9F3B6E161AA0471" modified="2018-10-10" version="1">MDKILYGTLCQQLLDKLSYDKNHVPFRPFSQDLPRPSWSTPAEWNAAIMVSKLFYFYIDEFTQQKILLFVAHFWRHDRGDPTSVSAAKTFVPTLLSSTDQLPQVQQDYISLLHSLSHDYNAFDIGRIFKSVVDFMSGVIAEAEFLPRISQSPPSDGQFLRRMTGMGDAFAHLCFPRALNIPPEDYILLIPELDNFMDHVNDVLSFYKESIVGEEAENHILRHARLNGVSVQESVEHFMMLAEQSAGNIRRLAACTPELQRVMELFLQGYIRFNTECPRYRLKECMQGIEYRWWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQZ2</accession>
    <name>A0A317VQZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_589115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463939.1">
        <property type="nucleotide sequence ID" value="XM_025615928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQZ2"/>
    <dbReference type="STRING" id="1450535.A0A317VQZ2"/>
    <dbReference type="GeneID" id="37118071"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY75312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="369" mass="39902" checksum="D3A55CCAC080E733" modified="2018-10-10" version="1">MPEMMKQWYVQGTNGAESLHLREVPIPVPGDYEVLVKFHAASLNYRDIMITTGTYVWSVRDGIVPGYLHPPLPTNPLTHQQPLTHLHPSSDAAGTIHTTGPKVTRFKPGTRVSPIFHLTHLYGPFHETNFSSSLGAKHDGIFQEYAIYNEQSCVEIPSHLTFREAATLPCAGVTAWNALYGGPRALKPGETVLTQGTGGVSIFAAQFAKIGGAEVISTTSSGEKAERLKGEIGADYVINYVEDEGWGGTAKGLSRRGRGADFVVEIGGAKTMGESVKAVAIDGQIAVIGRRAGNGFSGDGEGSHTTSVSTIRRVLVGSRQLHEEMNLAIEVNGLRPVVDERVFGLGELKEAFRYFETGRHFGKVVVDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VS59</accession>
    <name>A0A317VS59_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_538086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464411.1">
        <property type="nucleotide sequence ID" value="XM_025612417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VS59"/>
    <dbReference type="STRING" id="1450535.A0A317VS59"/>
    <dbReference type="GeneID" id="37114560"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY77224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="501" mass="54649" checksum="2B91C27234BB9709" modified="2018-10-10" version="1">MVSSFCWSCLTRLPPAPRAILPPTLTAQRVASFHTSTALFSSPIRKKKGEVAPAKFRQAKSAKMKKKKPVERTRPPAVGERKALKKRIVLSNPNALEVEGMQDLSAENMVDARLRGSILSLPVPMLDQLRAVQAFKPKQGWSIFRRPGTVVRRETLELGRLIDGISGEGENKGRVVRKIVTGVRGSGKTVHLLQAMSMAFTKNWVVITVPEAQDLVIANTAYAPLSDENPDVYVQNDATAALLSRTVTANQKVLSTLSVSQTHPALKSAVKPGMTLEDLAKLGIQDPAAAWNVFQALWTELTATAPAPGFEESFKSRPPMLVTLDNLAHWMKDSKYNSIDCKPIHAHDLVFVQHFLSLLKPNANKPTLPNGGLILYATSASNGPTIYGVTVALKQLAAREAGVKPSSPEYPQADPYLNADKRVLAVFEDIKSTAPKEGALELQTMGGLTREEAQGFMEYFAHSGLLRENITDEWVGEKWSLAGGGVIGELEKLGRRLRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSH3</accession>
    <name>A0A317VSH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_604550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464473.1">
        <property type="nucleotide sequence ID" value="XM_025616462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSH3"/>
    <dbReference type="STRING" id="1450535.A0A317VSH3"/>
    <dbReference type="GeneID" id="37118605"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY77286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="266" mass="29303" checksum="568D586529F32DA0" modified="2018-10-10" version="1" fragment="single">FPPPHIHHPQATHPHTHTAILLHGRGSNGPEFAEELFSSSTSKGQNLPSHLPSFRWVFPTSKDRWNSRFEEDICAWFDAYSLTDITEHQDTQVPGIRESVTYILGILEEEIKLLDGKSTNVYLGGISQGMATALWSWFCARDRLGGVVGFCGWMPFAERFGDEDGDGGLDGGRRVAAFCEGVVWGEVQGGWEGRRVLDSPVLLGHGVDDPMVSVELGRQVVGILKRSGIKVQWVEYVGAEGDGHWIKEPEGFDAILRFLESGSGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUB1</accession>
    <name>A0A317VUB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_473567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464251.1">
        <property type="nucleotide sequence ID" value="XM_025608481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUB1"/>
    <dbReference type="STRING" id="1450535.A0A317VUB1"/>
    <dbReference type="GeneID" id="37110624"/>
    <dbReference type="OrthoDB" id="5397087at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="410" mass="44622" checksum="88C07BD512CF88C6" modified="2018-10-10" version="1">MGSPVIDVDVCPNPRTKEENQERAFIAASRRKDRSLDARVESANRASSLHKQRTGKALLISRDIVEREAMYEEVDDRYQEKINRMLHAQSMQLQSEFNRNLMAAFAVNRPGALHQRRATSSHLNPRASLNGIRKMSLDLSGLRASVSEGMHTGPMTSPLGAHQTSYVLSPTYDGSSQSPSYPSVVPATSGQLPSYLTQTAGGPTWPAQLGGPQPMRSPWTAGFTSPPQQVPTTMGEMGPMPVRQFRDRLGSAPVIPVHTIPSPSLATPTAPSNGATVPPTTASRTAHPMYQHTRVRSEPSQAMRSQSLAHLSQHNSPHGLPLETEPIPTPDLCPTPSTPHSPTSTGQNPGLWGLELNKDEGMGYGQEHHIDPDFEDFSRFAFGLGSGSQLPESETAFDEFFTMEDFPVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWA7</accession>
    <name>A0A317VWA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_196203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464469.1">
        <property type="nucleotide sequence ID" value="XM_025606068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWA7"/>
    <dbReference type="GeneID" id="37108211"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY77282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="156" mass="17506" checksum="F63F92FEFE18EF03" modified="2018-10-10" version="1">MVYAVVTNLNLDMDMGNLIGWSQLPTRPQECDGLREVFTIQGCSTTRAKDYLISFDATAPGLPNYDGGMYLVNSGCRQDRCLRIRQSISVLFMLLPLGSSVDKDRSGCWLERHTGACGIRGQPVCDKVIVEAVYLPRFLYGWPERTDRPDQPLADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWI5</accession>
    <name>A0A317VWI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464455.1">
        <property type="nucleotide sequence ID" value="XM_025612425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWI5"/>
    <dbReference type="GeneID" id="37114568"/>
    <dbReference type="OrthoDB" id="4223701at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY77268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14959" checksum="44C01B7B689AB92D" modified="2018-10-10" version="1" fragment="single">MPTPTVTYTSLSTTTKTYFHSIDTHDLSTTISLFSPTATFTITTSRTTFTRQSEIHSMLSDFISRSKTMEHRVLNMVVDERERKVATQQRYTGEMKDGDILDMINCNFFEFDEEGRIVEVRVWMDGVGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXQ0</accession>
    <name>A0A317VXQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_472396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464623.1">
        <property type="nucleotide sequence ID" value="XM_025608428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXQ0"/>
    <dbReference type="STRING" id="1450535.A0A317VXQ0"/>
    <dbReference type="GeneID" id="37110571"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="STI1" evidence="5">
        <location>
            <begin position="56"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY78111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="108" mass="12225" checksum="207ABF2276A619C6" modified="2018-10-10" version="1">MKEYNKALDACTEAAEHDDGTHAREIEQQQQKCLDAQFSARAGETEQQTMERIQNDPEIMSILQDPVMQSILQQAKSDPAALQEHMKNSQVRMKIQKLMAAGVIRLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VY48</accession>
    <name>A0A317VY48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small nucleolar ribonucleo protein complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_626582</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464868.1">
        <property type="nucleotide sequence ID" value="XM_025617366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VY48"/>
    <dbReference type="STRING" id="1450535.A0A317VY48"/>
    <dbReference type="GeneID" id="37119509"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000518">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000935">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001420">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="957" mass="106548" checksum="EB716DF019069D52" modified="2018-10-10" version="1">MDIHRCRFVPYNPQAINALSFSHPPSAELAGRGVPTLRLAIGRANGDIEIWNPLRGAWFQETVLRGGKDRSIEGLVWTLDPPESSHDGSKLPGRLRLFSIGYSTAVTEWDFEQGRPLRHSSGNYGEIWCLAAQPRWQATRGKDGKLLPPAEGEFTGQHLAAGCADGSIVILSTADNDLKFLRIMRPSTKRSRVLSVTFQNRNTLVAGYADSSIRLYDIRSGQLLRTMSLGKGPGGGTKELLVWSVKCLPDGTIVSGDSAGEIRFWDAKNYALIQRLQGHVADTLDIAVSANGDTVVSGGADQRTVVYRKKDGEKGDKKARWAEVMHRRYHTHDVKTFAVYETRDISIVVSGGPDAAPVVLPLREFGKEHHRKLSSLPQIPQLASSPSSRLVMSFWDREVSIWRLHRGPTSHENSDGQRHRLVGKVLIQGEENITSAMLSADGKILVVATISTIKLFSVRRRKGDEKGTLRIQKLDVPKALAEDGARVVTVAPNGQWVCVVRPNSAMYLARIKPASTAQEKPHILSQLVKLNRATRHTRFEKASHGTLGDYERTVRCAVFSDDSKVLASGDLSGCVDTWSLQKAEDTPKKRNSAAGSDDESSDDEDQPVIEGERWHHAAEESPIPRLKSGVVLLSFRPPNPAKTKLLTSGVAKDEHRLMALTSEHQLVEFDAVEGKLSDWSRRNPKAFLPAEFRGVKDRAMGCVWDLSAARERLWLYGTSWLWMFDLNQDFPSPEELDASADNHEDLNASTQISKKANQKRKRDPFEEEDNGRKKPNSGAGDRMSLAQSDIFFGSKMRKIVGPDESQAEWVSLDKERSRGGDDEEAYDYDEAYTANNDVALARLRRERQFIETSTPLKRVSFGGKQDKLLSMTPGGGGGDFDTPSQKQLVQQGDHKSSQPPRRWWHTYKYRDLLGIVPLGSSDPDADTDNDNHFLEVAVIERPMWDVDLPGRYVRDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYP5</accession>
    <name>A0A317VYP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_471586</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464965.1">
        <property type="nucleotide sequence ID" value="XM_025608389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYP5"/>
    <dbReference type="STRING" id="1450535.A0A317VYP5"/>
    <dbReference type="GeneID" id="37110532"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="391"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="792"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY79393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1105" mass="121563" checksum="9FA6BDE44ACB3E1D" modified="2018-10-10" version="1">MPAERRSLRSNSKSDTSSSANGEKARSTSQNSSSNKDKPAPTRAAANKAKAASTTKAASSNSTANSGMGEQRDQPRANGSDPTENGVNGSEDVEMGEDTAGGPTSSFNTSQDRKGDEKMTVVVPPTKGSRLSGEKGTDQEGDVAMEGAEGEDTEPEVDPKVKAIQDIKTNFTLLERAVTHFDPRFTLRVLRSISSMRKHITGDVLAEVIEETYSATIVTASFLLNALDQAGALGSGRASAKMEIESEKTKSSPKEILPEVDIYLSILVQIYLYDRKEIQLGAKFSTNLIERLRTLNRRTLDSLAARVYFYYSLFYEQIAPLPPSPAATVTKIRQSLLAALRTAVLRKDVDTQATVMTLLLRNYLSTSHISQADLLISHNKFPPSASNNQIARYLYYLGRIRAIQLQYTDAHGHLIGATRKSPSSHSARGFYQASHKLLVVVELLMGDIPDRSIFRQPALERAMHPYFLLVQAVSVGDLDGFLNIVNTHSATFRKDGTYTLILRLRQNVIKTGIRMMSLSYSRISLRDICLRLGLDSEESAEYIVAKAIRDGVIEASLDHERGFMKSKEVGDIYATREPGEVFHERIRACLSLHDESVKAMRFPMNQHRLELKSAQEARERERELAKEIQEGDMDDEDAGGDFDAIYSLLRTSLPIMRARTVPASGLVLSSRVTPSTIVCWQCLRNDLLSSQLQLQTRKYHPTKRKDISPLGAAVSAAQTIFKGLPKAPPGISVDPLRMVGKELKFLTKNLRQLLGSGHPTLDKVAKYYTRSEGKHMRPLLVLLMSQATALCPRKPDTDNNSATVNDPISDPSILVDTNPDLSSLSSTSADAPYDFAGDKDILPTQRRLAEITELIHTASLLHDDVIDNAVTRRSFTSANLQFGNKMAVLAGDFMLGRASVALARLRDPEVIELMSTVITNLVEGEFMQLKNTAADEKNPVFTDDTLSYYLQKTYLKTGSLISKSCRSTAVLGHSVPEVVEAAYQYGRNLGLAFQLVDDMLDYTVSEAELGKPAGADLELGLATAPLLFAWKEYPELGPLVGRKFSQAGDVQKAREFVIKADGVEQTRILAQDYADKAIAAISDFPDSEAKAGLAQMCEKTMKRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZZ9</accession>
    <name>A0A317VZZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_537696</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464817.1">
        <property type="nucleotide sequence ID" value="XM_025612328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZZ9"/>
    <dbReference type="GeneID" id="37114471"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="60"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY78508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="551" mass="59114" checksum="F3E06210F1CF5098" modified="2018-10-10" version="1">MSPERNPTETSPLLGPQSNGSTTGAIPNIGRQDVESGEQTPLAQDQTKDVPEAGKGLRYIIPAISLGVFLSAADQTIIMASYGQIGSDLEALNLTSWIATSYFLTLTSFQPLYGKLSDIFGRKACLLFAYAIFGVGCLFCGVVQNIDQLIAARVFQGIGGGGMTTVVSILMSDIVPLRDRGVWQGIINIIYATGAGIGAPLGGILADFIGWRWAFIAQVPLCILAFIAVFFLLDVPAQEDSHWKDKLRRIDFPGAIVLVGAVFGFLLGLDRGSNVSWTIPITIVSLSVSTALFALFIVVEVFYAAEPFAPGHIIFNRAFFSAYACNFFSFGGWLAALFYIPLYFQAVDGVSATVAGLRLLPSIITGVSGSLFAGYVMKWTGKFYWLTVLAYAGLTVGLTTIFLASGGVTENTTLLVLGMMACAFGNGIGVTSTLISLISNATPEDQAVVTACSYLFRSLGSVIGLSLSSTVVQQLLRDRLAYALRDSKDIDQIVDGVRQSLDFIKTLDPAVGKIVRSCYGWATNKGFSFMIGIVFCAFLSSFFIKEKKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1J4</accession>
    <name>A0A317W1J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_603850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464552.1">
        <property type="nucleotide sequence ID" value="XM_025616449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1J4"/>
    <dbReference type="STRING" id="1450535.A0A317W1J4"/>
    <dbReference type="GeneID" id="37118592"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF81">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY78040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="521" mass="58205" checksum="1D4C45978C44B586" modified="2018-10-10" version="1">MGAILDSKSQDPEKTIPVTTKVDDVDVGQISQLDEAEVFLHEHGVSNDQLQEMLDDPVRMTKLRRRIDMILLPLMCGTYCLQYIDKQALSYSAVFDLFTDAHIDSNQYSWLASIFYFGYLFWEYPASYIAQRLPIGTVVSSFVIAWGAILMITASCNNFNGLAICRFLLGCFESPITPCFMMIVGMWYVRQEQPFRAGIFYCCNGVGSMVGGLLTYGIGQLDTFPVWRAVFLICGGATIFWGILMMLFLPNSILSSKRFTVEEKILLIGRGKQNQTGILNRSIKWYQIREAFIDPQVWLLFLFTLLNETINGGVANFGKLIIKGLVSSSLLTTVLGIPQGAFQVVFILTGTYLSSRYKNIRTFIMALYLIPTVIGVCLLWKLPRTNRYGVLFGYYIVGSYVTSLVLSLQMPSSNMGGYTKRVTATAFVFLAYCIGNIIGPHAFLSSEAPVYETGCKLILGCAICQIVCAGALRVLLVRRNRVWDEVAALPGEDAGVGEGEGEGEVMADLTDFENRRFRYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2N6</accession>
    <name>A0A317W2N6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_173629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465079.1">
        <property type="nucleotide sequence ID" value="XM_025605932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2N6"/>
    <dbReference type="GeneID" id="37108075"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY79507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="153" mass="16989" checksum="460E2C13278CD7B2" modified="2018-10-10" version="1">MRSDSMKFFEEARRALLARKKVPHGEVADGDPLPVRLPSFPLSSRWARTICFSSFSVAFLYLRTQPASQHAPSWEVRVIGRHDRTIWMPDPSRSPAGLRERRGGTEKLVKLGWAFSAGLRLPVASQSSTRPSIASLALIGPGTKSRIPPSPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2P5</accession>
    <name>A0A317W2P5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_587592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465448.1">
        <property type="nucleotide sequence ID" value="XM_025615836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2P5"/>
    <dbReference type="STRING" id="1450535.A0A317W2P5"/>
    <dbReference type="GeneID" id="37117979"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="255" mass="28588" checksum="0BD1FF7EF4B3D811" modified="2018-10-10" version="1">MEQPPSSQYSSHLVQQILNEIAQRVLTIRDHTELVFKDINPVNGLILCRRFVENANVERIHTQNPSLHGIQQQWGKNSNIDWVCDGRMTRDEGYRMMGIGVGTRFEGFTGYILSSDQPDLYVAGYWESIPSIVVEAGWSGSGDRLQAAKDLWLRGTSEVQVVVLLIWSKTLNNKVEGIAEVWSRAGEGGLAARRLAIFPEQNPLPYDDRIEFTKGQLIGLNTPISEPNTVLSLEMSQLRTLAEFVITLEFGMSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W350</accession>
    <name>A0A317W350_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thymidylate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_161487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465294.1">
        <property type="nucleotide sequence ID" value="XM_025605869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W350"/>
    <dbReference type="STRING" id="1450535.A0A317W350"/>
    <dbReference type="GeneID" id="37108012"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39059" checksum="8D8949220FD400B6" modified="2018-10-10" version="1">MAALTMTPATIRQPFASLDAPRMRSLLKNKMNLKNKQDGAMLLAKKQSLSDMDSENIDPTTLKHSTKRKRGAEDDGLEPAKEPCKPFKSSRMVPTTVESIGVTPRKPTTPTKPALSTPKSAPILRPAGRSPPPKSCKSFSRRSTIAKGRLESASRKTVHRPFSLATALSGSKSKRHSTPKAPASWSFDIHVDNEQDEMTNLMQHSTCVLDISDQEGKLETSGRGKENVPPAELGIELPRSRQRESPAAAARKSVMLEESREPLGDLVPADYYGEDCHAFSYAIVYDEEAEENAKAPVSSLPRPSPTSNRSKLSTVSSISALVEATTPAKSILEQNAEPSEAEIEIWESASAAEEAANAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6G1</accession>
    <name>A0A317W6G1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_537025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465439.1">
        <property type="nucleotide sequence ID" value="XM_025612175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6G1"/>
    <dbReference type="STRING" id="1450535.A0A317W6G1"/>
    <dbReference type="GeneID" id="37114318"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="84645" checksum="1485A7633ED80EE9" modified="2018-10-10" version="1">MENSSPPDYQALYLRAEEERQREAELRKQAEERERQAEERERQAEERQRQAEQERDQEREQTRRTTFAELIRYCHNYTSLCLRVESPSRSTTGTIPAPKGKRCPLQLLPWTECTAIQQEIYHSVCTYLAPPGQPAAQVFPSRTVLKGFGEEFKKRAMSSEQDLQSYERFGVENHVRDIIAELCRIRAAREEFQLGHGIQFDNHANALDAVDADQSKTDKSANSRPDQYCIHRVDSDKNTTIMTVEYKPPHKLSVENLRAGLRPMQFWDEVVRPDSVPTEGPEKLRYNAAWLTGSAVVQEYHVMLQEGLEYSYLTNGFALVLLRVPYDNPETLYYHLCEPNMEVNLDDELSYLQQPLTAVARVLCLCLMSFRSQYRDQEWRNATKKLPKWKTSFDHTRSQIPESELQQNPPDSQYTVSEYTSSESTTSEYIPSSSPAPSPAGTRRIPTRSRASCASPNLTSRHDSDSDADQAPGGRKRGFSQVASSSSSPSPQRSAHLAGDQYTPIGSQGQQHTAQFCTQKCLRSLQRGGQLDVNCPNIMLHRQGGDSSQHPINAKTLIKQLKQQLDENIDRDCTPMGGCGASGVPFKVTCTAYGYTMVGKGTTPRRWEEVKREEVVYRVLDQAQASAVPVFLGAIDLAKSYFVHGAGEICHMLIMAWGGEPIHKIERDTTITREIARSEKEICSLGVSHQDLRSDNILWNAELGRALIIDFHCSKLNHRPMKRRVKSPGRHPCRELHKRKRLCIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W7M0</accession>
    <name>A0A317W7M0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_536913</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465739.1">
        <property type="nucleotide sequence ID" value="XM_025612145.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W7M0"/>
    <dbReference type="GeneID" id="37114288"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001465">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="526"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1128"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1152"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1194"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1237"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1263"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1392"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="100"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="785"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="753"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY81671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1421" mass="157993" checksum="4AD80AB9B8C92298" modified="2018-10-10" version="1">MEEDKEKVSYSLGVPESRDDSDSTATVLEEDPTITSRNPGVSLADGWALMPQVKQQNERDMQSGFKRKELGVTWQNLSVEVVSAEAAVNENFLSQFNIPQHVKESRNKPPLRSILQNSHGCVKPGEMLLVLGRPGSGCTTLLKMLSNRRLGYKSIEGEVRYGSLTSDEAAQYRGQIVMNTEEEVFFPTLTVGQTMDFATRLKVPFNLPNGVESPEAYRQEAKDFLLQSMGISHTNDTKVGNEYVRGVSGGERKRVSIIECLATRGSVFCWDNSTRGLDASTALEWTKAIRAMTDVLGLSSIVTLYQAGNGIYDLFDKVLVLDEGKEIYYGPMTEARPFMEELGFVCREGSNVADYLTGITVPTERKIRAGYENRFPRNADMILAEYVKSPIYTRMTSEYDYPNTDLARERTSEFKESVAQEKNKQLPNSSPLTVDFISQVKTCIIRQYQIIWGDKATFFIKQVATLVQALIAGSLFYAAPNNSGGLFVKSGALFFSLLYNSLLAMSEVTDSFSGRPVLIKHKSFAYFHPAAFCIAQITADIPVLLFQVSVFSLVVYFMVGLTMNAATFFTYWIIVFTATMTMTALFRAVGALFSTFDGASKVSGFLISALIMYTGYMIKKPQMHPWFGWIYWINPMAYGFDALLSNEFHGKIIPCVGTNLIPSGEGYNGNGHQSCAGVGGAIPGSTYVTGDQYLASLSYSHTHVWRNFGILWAWWVLFAGATIFATSRWKSPGETGSSLLIPRERVDAHRQIARPDEESQVNEKANKKPHDESTQDASDLDKQLVRNTSVFTWKGLTYTVKTPTGDRVLLDNVYGWVKPGMLGALMGSSGAGKTTLLDVLAQRKTEGTIQGSVLVDGRPLPVSFQRSAGYCEQLDVHEAFATVREALEFSAMLRQPRHVPPEEKLKYVDTIIELLELHDIADTLIGRVGSGLSVEQRKRVTIGVELVSKPSILIFLDEPTSGLDGQSAYNTVRFLRKLADVGQAVLVTIHQPSAQLFAEFDTLLLLAKGGKMVYFGDIGDNGQTVKDYFARYGAPCPAGTNPAEHMIDVVSGALSQGRDWNDVWKNSPEHTNALKNLDDIVSDAASKPPGTVDDGNEFAMPLWKQILIVTKRSCVAVYRNTDYVNNKLALHVGSAIFNGFSFWMIGDSVGALQLRLFTIFNFIFVAPGVINQLQPLFLERRDIYDAREKKSKMYSWIAFVTGLIVSEIPYLCMCAVLYFVCWYYTVGFPSDSNKSGAVFFVMLMYEFVYTGIGQFVSAYAPNAIFASLINPVIIGTLASFCGVLVPYAQIQEFWRYWIYYLDPFNYLIGSLLVFTTFDAPVKCKKSEFAVFSPPNGSTCQQYLADYMSGMGARMNLINPDATSDCHVCEYSQGSDYLYSINLKDYYYGWRDAAIVALFAISSYALVYGLMKLRTKASKQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8Y3</accession>
    <name>A0A317W8Y3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative ribosomal RNA processing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_625470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465859.1">
        <property type="nucleotide sequence ID" value="XM_025617288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8Y3"/>
    <dbReference type="STRING" id="1450535.A0A317W8Y3"/>
    <dbReference type="GeneID" id="37119431"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY83074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="315" mass="36245" checksum="2BB28C8604BCD5BC" modified="2018-10-10" version="1">MSDITKTPFVRDLASSDKKLRDKATDSLTLFLRSKTDLTLIELLKLWKGLFFCFYHSDRPLTQQALARTLSYSLVPTLPRSTLHRFLRAFWITIGRDFHSLDRLRLDKYLHLIRCYVGVAFEVFLKPTASASAATANGKRKREDTSSSSKKRNNNKKNKKQSRQEEEEETSRAENAANGEKWAALESYITILEEGPLCPVNFDPDQPAANEKEDYIPMPHGPDGLRYHVMDIWVDELEKVLEFEGEEGARKPKGEVPMELLLRPIEKLKADSPYKPVRTRAAESLDDDRLVEWGFKTRKVESDDEESDEEWGGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDC1</accession>
    <name>A0A317WDC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465987.1">
        <property type="nucleotide sequence ID" value="XM_025612071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDC1"/>
    <dbReference type="STRING" id="1450535.A0A317WDC1"/>
    <dbReference type="GeneID" id="37114214"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="212" mass="24629" checksum="176FFE8C604C0A04" modified="2018-10-10" version="1">MYRDQDTLYIVMKYIPAMSLGTAWPSITEANKSSIVEQLRCIFDQMRALPSPGFYGSVNRGPVPHRYFFSGERDPAVTGPFQTEEEFGKAITLRSQTMWIESNIHSFFSDYLARHLPSALRNHPPMFTHGDLYRENVLVRKTVDSVTNEEAYEVAALVDWEAAGWYPSYWEYAHIFPLLQWTDDWPAYVEKILDPLPMEGVIMRLVFNDLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDR7</accession>
    <name>A0A317WDR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NEFA-interacting nuclear protein NIP30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_599746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465993.1">
        <property type="nucleotide sequence ID" value="XM_025616332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDR7"/>
    <dbReference type="STRING" id="1450535.A0A317WDR7"/>
    <dbReference type="GeneID" id="37118475"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="240" mass="27053" checksum="DB9FC6794E1F2C50" modified="2018-10-10" version="1">MSSGFVSAGTDQEPVQRDDEWHRVQQELEEERRRKAELGRQEDGKSLYEVLQQNKMAKQEAFEEKMKLKNQFRSLDEDEVDFLDSIMESTRAKEAAVKKETAEQLEVFRRHREEVEKVLLEDTAADVTPAAEGEDWKIPARKRRREKSKDLLIPGKKRKSLGGDLTPDQIADKDSNSNGQKSKSESTQKKPEEPKQPANLPVAEKPINPPQTSPDQPASKPAAKPASLSLGLADYGSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDS2</accession>
    <name>A0A317WDS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_547204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466541.1">
        <property type="nucleotide sequence ID" value="XM_025613320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDS2"/>
    <dbReference type="GeneID" id="37115463"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY84616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="127" mass="13703" checksum="F758DB2369E9AF20" modified="2018-10-10" version="1">MNMTSIEDLSNHGRAGWGKVKIMPGRHAAGALDVFGVADNWCAGPENLSYRQDQLSLAVLASSSSIWGGFQVQSPNSNVPFLLSHCLLLFTSSSWDLSSEEVPVISSRLLVMAFEDHAILLLSGNAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFS0</accession>
    <name>A0A317WFS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_599327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466336.1">
        <property type="nucleotide sequence ID" value="XM_025616313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFS0"/>
    <dbReference type="STRING" id="1450535.A0A317WFS0"/>
    <dbReference type="GeneID" id="37118456"/>
    <dbReference type="OrthoDB" id="5280547at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY83868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="506" mass="57010" checksum="F571F1895A54E72D" modified="2018-10-10" version="1">MTFCGRPSKACLSCRQRRIKCNRAVPVCRQCQRAGKQCTGYRDEPPLLFRDENVRTVRRALRAKECSDRRNTAQLIHLNGNPENDIQHTPGVVPPSQHLTVPMDEQGLRIFFCHFATPHGVTGSKEPPRSHPFLLRIMEDGFSRQAAVAIGLAAASNSGNGPALLKFARQKYGRTLQELRQTVQAATMTKDLDYILLIILMLALFEFVDCDASSITAWAVHADGATAVLQRFSARGGFSVDYRAQLQYYFSMFIKYFFIGGSPPVDWARSSTWHMPILPTEGQPAVTLMGILMQLAQLYLTLLHGMNMPVEEVARTALAIASELAAWKATLPVTWSYELRYSTDMSHTFHGLYHIYHDAWASRVTNNYRYARLLVNDIILTYTDRNAGGYEQVSIQNQATTTITQMATEICIAASSQVYHEIYQPEIDNLSPPPASNGVFMVLFLLNVAAWGTGVPDVLFEWVIDTLRTIGHIKGIRHALYLIPKLQKIREQRKLGLRPLLFQMFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WGD5</accession>
    <name>A0A317WGD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_495536</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466025.1">
        <property type="nucleotide sequence ID" value="XM_025609266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WGD5"/>
    <dbReference type="STRING" id="1450535.A0A317WGD5"/>
    <dbReference type="GeneID" id="37111409"/>
    <dbReference type="OrthoDB" id="10029320at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11051">
        <property type="entry name" value="CYP59-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF222">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016336665" evidence="5">
        <location>
            <begin position="23"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY83240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="562" mass="63505" checksum="60820932ACE2AC34" modified="2018-10-10" version="1">MFTQAILFILLSLLLSYLLNRAQHLRFKQYGNWPQLTPSFIWGHMKVINEFIVRGERKRHIDIVFREIQGYLDNPPLVLYDLRPLQYPLCVVGNHEVAEQVSRSTKSFPYGMGKSPWMRALEPLLGPYSIITSEGEQWKALRKRFNPGFAPQHLLTLLPCILDKTMRFTEILDGYARSGEEFSLNDRCIGLVFDIIGAVIMDKDFHAQHDVSKQDELVRLYRELTATYRSGSSVQYVSLNPRVIRQRRALTRRIDGLVIDHVKIKFAELKAQSNEKPSRSVLALSLQDINILNDRVLQETCHQLKSFLFAGHDTSSILLEWAFYELSRTPRALDTLRRELDNIFGPDSSPAVVQEKLLAPGGDGLLKRMSYTSAVIKEILRLYPPSGSARYMPPGTGFNVQLPDGKTLCLDGVIIYNCTTLVQRDEAVYGPTKDEFLPERWLGYIDTGLGLPMDNLDDTGNGPVAADRVPATAWRPFERGPRSCIGQELANLEARVILACTARRFDFMKVGLGAVARDSTGAFILDAKGQYEVESELFNTMQVTAKPVDGTMMKVRVAELSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WGZ9</accession>
    <name>A0A317WGZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Adenosine kinase</fullName>
            <shortName evidence="12">AK</shortName>
            <ecNumber evidence="4 12">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_624875</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 12"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466761.1">
        <property type="nucleotide sequence ID" value="XM_025617247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WGZ9"/>
    <dbReference type="STRING" id="1450535.A0A317WGZ9"/>
    <dbReference type="GeneID" id="37119390"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1110.10:FF:000001">
        <property type="entry name" value="Adenosine kinase a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="13">
        <location>
            <begin position="28"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY85744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="353" mass="38345" checksum="4A8CFF6D61CF63C8" modified="2018-10-10" version="1">MAAPQGYPLLCLENPLLDIQAVGDAALLQKYGLKDNDAILAEEKHMDLYGELFQKQDVKLIAGGAAQNTARGAQYILPDNSVLYIGCVGRDKEAEILKEACAKAGVHTEYRIDDAQPTGKCGVIITGHNRSMCTHLAAANEYKIDHLKQPHIWSLVEKAQFYYVGGFHLTVCVPAIEALGQEAAAKNKVFMLNLSAPFIAQFFKEQLDTVLPYTDYTFCNETEARAFSESHSWGTDDVVEIAKKLAQLPKKNTSRPRVAIVTQGTLPTVAAIGKPSGEVEVKEFPVREIPKSSINDTNGAGDAFCGGFCGGIVQGKSLEESIDMGQWLASLSIQELGASFPFPKQAYSPTNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH07</accession>
    <name>A0A317WH07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_101704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466442.1">
        <property type="nucleotide sequence ID" value="XM_025605458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH07"/>
    <dbReference type="GeneID" id="37107601"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="152" mass="17131" checksum="66F44C38C2A445C9" modified="2018-10-10" version="1">MIPADYSRYCKLRGILNFFLIMVRGSLTLLLGSRWKRRLLFGLATLPSRSSCMLTCSLLCRCWKVKSNGLLAVSAVVDFRLSLLLCLLQGLYLISGWLAISSVLFPVCSPRLRQQALRTRYDERCLPFAPVGHDVTGLLILLHISATITSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHH9</accession>
    <name>A0A317WHH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_453014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466850.1">
        <property type="nucleotide sequence ID" value="XM_025607548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHH9"/>
    <dbReference type="STRING" id="1450535.A0A317WHH9"/>
    <dbReference type="GeneID" id="37109691"/>
    <dbReference type="OrthoDB" id="4483697at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY85833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="89" mass="10020" checksum="3C4C2DE6F988670A" modified="2018-10-10" version="1" fragment="single">SISTRGRQHIKAACDECRRRKLRCDGQQPLCGGCQDSGSICEITQRGTRGPRKGYIKALKNRVVDLEAMLESRIDPQQQQHSTETSDFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WIW5</accession>
    <name>A0A317WIW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_466806</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466995.1">
        <property type="nucleotide sequence ID" value="XM_025608180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WIW5"/>
    <dbReference type="STRING" id="1450535.A0A317WIW5"/>
    <dbReference type="GeneID" id="37110323"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1360.10:FF:000018">
        <property type="entry name" value="Type II DNA topoisomerase VI subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="12">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="13">
        <location>
            <begin position="202"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY86404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="387" mass="43380" checksum="94B8B4F393D23DA8" modified="2018-10-10" version="1">MESSGNDDNDNRPRENVSASSQTPVQRYIQKTLSVVLDELSSSDGRPSITLKQRNRKPAFLFVNPQTMALETRETQMHTTYTWPGSDANEAWRFTVAFRVLTAIAEAVQAGLVVSKRDIYYSDPPCFGSQKVVDALVDDFAHTMEVDRAALYVEAAAKGLVGGYYQLSMRNHEVLDARFSNQDALIPRVQDINKIDITAVDWVLILEKEAVYRRLASSNYHIISAAGKGILVTGKGYPDLNTRAFIRKLFDCRNQSTQRPRFYALVDSDPDGMAIMATYKYGSVAFAHENRNLNIPGLHWLGLRTSDVISGADPHGDDALIHLTERDRKKAIAMLGKNPIWAADGPEPEWRAELQQMLMLNVKAETEILYDRDGGLVGWLDQRLVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJA1</accession>
    <name>A0A317WJA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Elongator complex protein 3</fullName>
            <ecNumber evidence="17">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO94DRAFT_493655</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17 18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17 18">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="17"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466738.1">
        <property type="nucleotide sequence ID" value="XM_025609206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJA1"/>
    <dbReference type="STRING" id="1450535.A0A317WJA1"/>
    <dbReference type="GeneID" id="37111349"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15 17" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12 18" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 17 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 17" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="21">
        <location>
            <begin position="101"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="20">
        <location>
            <begin position="415"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PWY85721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="575" mass="65010" checksum="FA87EFE4E282BAA1" modified="2018-10-10" version="1">MATVTMTMPPPPKSKKNAKLPPENERFMRACSDIANALIQEYEAQRDPKKPKRDINLNKLRGQVAKKHALATQPPLTAIIAAVPEHYKKYILPKLIAKPIRTSSGIAVVAVMSKPHRCPHIAYTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPFEQARGRVDQIKSLGHSVDKVEYIIMGGTFMSLPEDYRESFVAQLHNALSGYQTDNVDEAVQAGEMSNVKCVGITIETRPDYCLDQHLSSMLRYGCTRLEIGVQSLYEDVARDTNRGHTVAAVAETFKLAKDAGFKVVSHMMPDLPNVGMERDLFQFQEYFENPAFRTDGLKIYPTLVIRGTGLYELWRTGRYKNYTPNALIDLVARILALVPPWTRIYRVQRDIPMPLVTSGVENGNLRELALARMKDFGTTCRDVRTREVGINEVKNKIRPSQVELIRRDYTANGGWETFLAYEDPKQDILIGLLRLRKCSPTHTFRPEFTGQQTSIVRELHVYGSAVPLHGRDPRKFQHRGFGTLLMEEAERIAREEHGSQKISVISGVGVRSYYARLGYTLDGPYMSKMLDPIEDEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJT4</accession>
    <name>A0A317WJT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_87246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467180.1">
        <property type="nucleotide sequence ID" value="XM_025617721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJT4"/>
    <dbReference type="STRING" id="1450535.A0A317WJT4"/>
    <dbReference type="GeneID" id="37119864"/>
    <dbReference type="OrthoDB" id="2431938at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY86589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="441" mass="49024" checksum="BBAD7B947748C4CF" modified="2018-10-10" version="1">MSPTPFKVIVVGGGPVGLTAAHALSHAGIDFVVLERRDSVVLDQGASLVLGPPTLRVLHQLGLLDPLMAVGGEINTNVSLTHQGHEFRDSDCFRIIRKNHGSAPVAFHRAHLIQTLYDKLPEKAKSQYLVNKKVSDIESHDTGVRVTCADGTAYDGSMVIGADGVHSKTRQVMRRLALAADPTRTWDAENPFTAEYKCMWCSFPRRTETGESTETQNIDKSVMYLSGRERGWIFLYERLPQPTTERINYTPEDIEAMAARFAEYPITETLRVKDVYAERFTAGMANLEEGILEHWGWGRMALVGDACHKYTPNAGLGLNNGIQDVVVLCNGLHKALQSATGEQLDTTTLGRVFDEYQTERAEPILRDAKRSAQVTRLHAWASTFYYIMARYILSWGWIEGLLLNYQAAPKIKQGAVLKYISATEPFTGLVKWDHPLDGSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKK8</accession>
    <name>A0A317WKK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_536329</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466655.1">
        <property type="nucleotide sequence ID" value="XM_025611991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKK8"/>
    <dbReference type="STRING" id="1450535.A0A317WKK8"/>
    <dbReference type="GeneID" id="37114134"/>
    <dbReference type="OrthoDB" id="30840at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004059">
        <property type="term" value="F:aralkylamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000141">
        <property type="entry name" value="Acetyltransferase, GNAT family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051635">
        <property type="entry name" value="SNAT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10908:SF0">
        <property type="entry name" value="SEROTONIN N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="148"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY84730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="287" mass="32426" checksum="171873D83BF5995E" modified="2018-10-10" version="1">MSDQTTHHYQEPIDGLKPLSNADGFSLPATASDLSRRAELSYADGQPLGDADIEDDDDDEEEEVEEEYVAVDHDDINEYPYWFRRPPVHHRTKLDELHPFVQVLTESNVEDCVTVEQAFPEHERCSREKFRYRLSRCPELCLGLFTLPILREGEPKPRPTLVGHVIATRTSSPVVTDKSMELPAKWQTERMTIENGETVGHDEYGSTIAIHSLAVLPEHQGKQVGSTLMKSYIQRIKDAQIADRISIIAHGPLVAFYESFGFENRGPSKCQFGGGGWVDLVFELSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL39</accession>
    <name>A0A317WL39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_67254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467311.1">
        <property type="nucleotide sequence ID" value="XM_025617596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL39"/>
    <dbReference type="STRING" id="1450535.A0A317WL39"/>
    <dbReference type="GeneID" id="37119739"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32821" checksum="DFE6BD914DE12FA5" modified="2018-10-10" version="1">MEYDFPIHQTLPFGMYQNRLTGFLTADVMAAAGSAALVTPAVMILDRLVVEKSSHNQPMFPAFRRHLWVSITQPATFLTSRPSLLVWSLYTATFAAANATETVLEQVYPHVDQAMAGTAKFLSTFVVNSSVGIWKDVKFAQLFGHKATPATPPQTPTASPAPSQSKILRVSRSIPFATYSAFLIRDALTIFGSFSLPAMVSASIPDSVASNEYLKVLMAQLAIPASIQLISTPIHLLGLDLYNRPMKLSASDRFGRVSRDWIGASLTRMCRIIPAFGIGGFANSESRAFFHEQLRRCEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL72</accession>
    <name>A0A317WL72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_565978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467277.1">
        <property type="nucleotide sequence ID" value="XM_025614526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL72"/>
    <dbReference type="GeneID" id="37116669"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013:SF7">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="2">
        <location>
            <begin position="21"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="308" mass="34709" checksum="E5FF97DBF6852DDB" modified="2018-10-10" version="1">MPIKRDNPTGRLLPDIYKDSHQVHIFTAFAAIACYNAVELMILCLSAFKRRGSTYFWSLLIASISILPQCIGYVLPFSRPEISPYGSATLILVGWCGMITGHSLVLWSRLHLVLQDPRVLRYLLRLIILDDILLQIPITVLLYGTVSSQWELFNNGYNIMERIQLVGFCLQEALLSGIYVWEAAKLLQLRPEGRHRRILAQLMLINITILMLDFAVVAIQYAGYYAVQVMFKPVAYSIKLKLEYAILGRLVKVVKAANAQHPSTTQGFDMHFDMLPSADGVRQTEGGPVDGHRAGVHSQKWYVRSSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLD1</accession>
    <name>A0A317WLD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_596658</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467514.1">
        <property type="nucleotide sequence ID" value="XM_025616259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLD1"/>
    <dbReference type="STRING" id="1450535.A0A317WLD1"/>
    <dbReference type="GeneID" id="37118402"/>
    <dbReference type="OrthoDB" id="5599552at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="15"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY87306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="435" mass="47863" checksum="255F91C6F31A13A6" modified="2018-10-10" version="1">MSASTFPDASLARDSQSSDFDLIVRQQPNRARVAGGKEKERKPVDPPPIVQIRVREEGTYLAQHYLQSPYYFMCCSLYDASEDNPVQVAPSTALTGTLVSSLHRLKDVDNSDGGFFVWGDLSVKIEGDFRLKFTLFEMRKDIVTHLKSTITERFTVYPPKSFPGMAESTFLSRSFADQGVKLRIRKEPRTLIKRPVPRPEEYPQPIPRSPDRSSIQMPSNAFSGYPPTSRDYAYYGQAHTSKRPRMSSIDLGTRGMYDTDGRMRQMDAYPQTAIYNQAGGYPTPIMQGYPTGHTAVPDYAMSYGIPSSTQVPQMQDPGAHGRSSQQASMQSLGMVNAAPGTPTADSTGAMMPQGYARSQYQTGTGSTILPPLQRNRNYTQGTNGAGTRGYFDQTSQAATPVLPSQPIATNDVDRYGSTPGQAAYEHPVSANGTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WM29</accession>
    <name>A0A317WM29_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_466993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466973.1">
        <property type="nucleotide sequence ID" value="XM_025608188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WM29"/>
    <dbReference type="STRING" id="1450535.A0A317WM29"/>
    <dbReference type="GeneID" id="37110331"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016394253" evidence="1">
        <location>
            <begin position="19"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="435" mass="48159" checksum="C721F0C7E2633798" modified="2018-10-10" version="1">MFINYLIPFMLVAPPVIARTGPQAVFAHFIVGNAAAMTPEQWESDIRDAQEAHIDGFALNIAPQDSYTDDVLDKAYTAAETVGNFTLFLSFDYGSGGPWPADRVISTINAYRNRSAQYNYHGKPLVSTFVGAGSADDWPYIKQFADCFFMPSWSDLGPAGTQAYLDTIDGAFSWDAWPVGAQGKNVTSDREWMHALSGKPYMMPVSPWFYVNLPQWNKNWLWRGDDLWHTRWEQVMNLQPAFVQIISWNDYGEAHYIGPIYDAGMPDGSSSYVLDHPHDAWRALLPHYIAAYRGTNTTDPSQSNGDLPVADKIVYWYRENPSHAGSANGTTGNNPAMGQEEMMPGQIAQDRVFVSATVEDASEIFVQIGYSPPTVLQASGPGINHFSVPFNGQTGPVRIVMMRNHREVAAAVGPAITEECKDGNVNWNAYVGSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNA7</accession>
    <name>A0A317WNA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_72969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467459.1">
        <property type="nucleotide sequence ID" value="XM_025617627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNA7"/>
    <dbReference type="GeneID" id="37119770"/>
    <dbReference type="OrthoDB" id="4084551at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="279" mass="31366" checksum="BC9C4662105CABFA" modified="2018-10-10" version="1">MRMIRIFTPCGPPTVTTWNNESPDHTTTSNLRSYTPTVPPGDFPVCTDPRGPFRPFCLPEDGANVTVGGTYYITWDADFYPLNATITIELRYPHSTKGDSAFTSDKTDNSYGYTHIHMHQAWLQGKQRNPLTLYIIELDAVSDKRASARQGPTVFLHPKPVEHRIPPPRTPFNKLALYIGLPVSLSVVILVVAGLYFGMRESRRIDLGNIMGPGYGIRKSKVQRLGRSRGELGGSSLERYSDDMDWDISVAQPDRQDGLERSLSFAFKRDSSKLKSWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNP6</accession>
    <name>A0A317WNP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1909-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_585551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467877.1">
        <property type="nucleotide sequence ID" value="XM_025615698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNP6"/>
    <dbReference type="GeneID" id="37117841"/>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY88094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="78" mass="8531" checksum="95C7477EA75F760E" modified="2018-10-10" version="1">MGNGAKAATKRERNAKDTKTAGKSQLKSNEAAKDIICQVCRSTFLKTTRGPALTEHAANKHNKTLQDCFPNFVDVPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRD6</accession>
    <name>A0A317WRD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_56269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467635.1">
        <property type="nucleotide sequence ID" value="XM_025614309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRD6"/>
    <dbReference type="GeneID" id="37116452"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016430783" evidence="2">
        <location>
            <begin position="27"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14743" checksum="E6CA300D831CDD5C" modified="2018-10-10" version="1">MHKRYGRVPVLCTIRILLVFLMTGSCSNIHGYVECLSYLIDVWEIVILVIILYTDLSTSWALRQYCSMLTCSAMIHGTLDESKIRYGSEREIGHGDDGSLVDLTRYGGQGYPIQWHPSLSYSSPAPRVGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRF8</accession>
    <name>A0A317WRF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_45083</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467957.1">
        <property type="nucleotide sequence ID" value="XM_025607538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRF8"/>
    <dbReference type="GeneID" id="37109681"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY88595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="171" mass="19712" checksum="BFB98349DECA901C" modified="2018-10-10" version="1">MEKERKPTHLSNAYYQSLRSLCSEYHHPLVAQEKVPNASICFFSLFFFFPLETMEYFLLPCITSFQAKLPLRNSIVCRLLKVLNANPSTSAGWHEANLRPRSKNPWSTTSNHLHQTDKDFSIGNSIYQTGHGCKRPFSKNNVGGSDESFFHENSNLVLFGIFYRKPMTIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRH8</accession>
    <name>A0A317WRH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_534904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467685.1">
        <property type="nucleotide sequence ID" value="XM_025611650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRH8"/>
    <dbReference type="GeneID" id="37113793"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016355158" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10422" checksum="99F9E9C8AD61611F" modified="2018-10-10" version="1">MIEHTYLLLFSAALSESQVPASGSKTWMEINKENIPRGIPSALGTGWPVGNQSLEGAYLAQQLYLLSLECNVLDNLMACENQSGDPAHPPGNVERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSY1</accession>
    <name>A0A317WSY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_535457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467548.1">
        <property type="nucleotide sequence ID" value="XM_025611788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSY1"/>
    <dbReference type="GeneID" id="37113931"/>
    <dbReference type="OrthoDB" id="5312133at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055:SF1">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016397429" evidence="2">
        <location>
            <begin position="29"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="589" mass="65879" checksum="4AA8A7E7855D283B" modified="2018-10-10" version="1">MIPHRSTALITIIVFVALVLVIFSSSPASDPSSGEEVSGPAKYVPKLPSFSDLHLPSFHPTVHTPPEPQPNSTSGESKWFSDWSWINPFSSSITLDESRTVLPPLRHRPFIYTYYEPNKGNDREEDNADAQLLLAWRRAWFAQGFRPVILGPGEAMNNQLYELVQPMNLKPELEAELFRWLAWGHMGDGMLADWHCFPMARYDDALLTYLRRGTDPALITRFDRIGNALFAGEKSRINDAIKKAIKKVNDKSTSMVELIPADFFTVEDSNALALYDSAAITSFYSAVAEKIVSSPTAGRLALAELINAHLHNTLQNAFPAGIAVLKPFPEHTTALVEPALRLAKALVQCPSSPVPRSCPPNLQKCHPCDAEKPMQISQPATYRNTTQVFTIGTLPHPFTLISLQQDSTEVTTRHIRRETDRDVWLAEVTKEHLGTEIGGSPRAVVFKRAVADDAVVGTSLWMTVETLPPQAGQSLPSELLDEFEWQFGFHIPRDGKVDAKNEGETKESVQQANPNEQGVEKEYNILKQAREFLKGKGTNRVGITDVAEAWNLADTEVWRFVRAYRARSVVERTKWEEEERDFVGAKPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUW7</accession>
    <name>A0A317WUW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_46477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468000.1">
        <property type="nucleotide sequence ID" value="XM_025608085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUW7"/>
    <dbReference type="STRING" id="1450535.A0A317WUW7"/>
    <dbReference type="GeneID" id="37110228"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="37975" checksum="7C4D592760B96C69" modified="2018-10-10" version="1">MEMELDMAPTPSQSIHIEPDPNSDDSLWITSELRDPDTDSLQSLTSSVLAYEYRNGRRYAVYGSGRYVLPNDESECDRIDLLQHIFGMLFGGRLVFAPIPSPQRILDVGTGTGTWAIDVATMYPRAQVTGTDMSAHQPSWVPPNLSFIIDDAELEWSYSSQFDLIHMQGLNGAIRDWPRLFKQAYDHLAPGGYLEVKDTDFKATCDDNTIPTTSSLRTWENECVRACTLLDQTLTAPAHVRRWMEAAGFLDVEERLFRLPVNSWPKDPELKEIGRFQNFQYMQALSPYALGLLVEVLGWAREETEVLLAGVRENLRDRRLHGYHIVRVVTGRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVM4</accession>
    <name>A0A317WVM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_555577</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468794.1">
        <property type="nucleotide sequence ID" value="XM_025613812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVM4"/>
    <dbReference type="STRING" id="1450535.A0A317WVM4"/>
    <dbReference type="GeneID" id="37115955"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY90416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="391" mass="44351" checksum="5668DD61F673E27E" modified="2018-10-10" version="1">MRASTQTRGRRSHQKSRHGCQQCKLRKVKCGEEKPSCINCRRHGVTCSFAQSPSCHDRSPSCNQVPTPQDNTRTIVSGSPGSDGQSQAAVAPDLAIADLELLHHFTTSTAYTFSHHPVLQSFWRVEVPQIGFTAPYTLQAILALSALHLATLRPERSQSYIAQANIHHEAALKLATPEMANITPENSAPLFLFSALSTFIWCAKPLKLGNFLFWENHEIASWLVLIRGTGTILDFADEALKNGPLASMFSARARNRISEPVPQHQVLENLRNLVMADVQEEHTANICNIVIDEMNRPFILCLERNLRLETADVFIWLLRVPHEFLLLLKDYQPLAMVIVGYFCVVLHQLEWMWCMRGWSTHLLSQIYNQLSPAYRAWIRWPIEQIGFLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVY2</accession>
    <name>A0A317WVY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_28485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468914.1">
        <property type="nucleotide sequence ID" value="XM_025606656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVY2"/>
    <dbReference type="GeneID" id="37108799"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="96" mass="10857" checksum="05BB5298B1551B25" modified="2018-10-10" version="1">MHLRHSKPCNTLGEPTEWPVQQKGWKLRSARLPAGPASERRPFRGSRRPAAPRAACPFHPLLFCHCRYTIDTYTTLSSVYLVLAHASTRSVGVVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYI5</accession>
    <name>A0A317WYI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_394158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469194.1">
        <property type="nucleotide sequence ID" value="XM_025607344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYI5"/>
    <dbReference type="STRING" id="1450535.A0A317WYI5"/>
    <dbReference type="GeneID" id="37109487"/>
    <dbReference type="OrthoDB" id="4471151at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="159" mass="18345" checksum="A4F18E695EA52B76" modified="2018-10-10" version="1">MHPAPQGHGIQDFWVYRICLASRSTLDCMLQIVMDCFASLMPCWIKQCLGSIRSDIQKEQVIFFADAERGPNNLMITFLRDRFYDRFTWTEFKSLGPPAMAAVVRAGWRCVALDQIAESIRAGRFDEKELGKLLNEARERRKRVSIRKPSDPVSVFEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ50</accession>
    <name>A0A317WZ50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_533749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469351.1">
        <property type="nucleotide sequence ID" value="XM_025611390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ50"/>
    <dbReference type="STRING" id="1450535.A0A317WZ50"/>
    <dbReference type="GeneID" id="37113533"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="527"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY91623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="577" mass="65370" checksum="B9D8004D5258A0F2" modified="2018-10-10" version="1" fragment="single">MAKYWDDLAIAKSLMDLSAEGERLKGKRNSPETQPNDKKPDPNKAIRTHEILSELHWSLDHIAFANMGGFALEYTPEPDTAPNIDSPGATSGESGSSSTGNPLGSIVKSCLSAFKDILSWLKPKEVSWDYLPSKYDRDHKLWYLNADDIIKLCDLKGVGAKKDRGEQHDEKDEEKKGEERKDEQTTQQRNLETIMHKLQIEPAEIADRSKSDILMRVIAVGQIIWVIIQVIARAVRHLAVTQLEVAVVAFALCAIMMYWLNRHKPKGVSLPVLIPCDSPDPDIKEILKKELSETSPTPQQNPPQIPRRDGLPWSARFRRIFLQFFGQDGRIRSKPIRNGFTISDADAGRSDFRSQFADVSLIVGGVVFGGVHLVAWRFAFPTHIEQILWWAAAAWCAFFFPFVAVQFFYVDTIHRRLFAPVLRILFRVLDKLGLEDLPLAFVPKTLREKKELELRPRYFRKKNPPRDAETGTPEGSDAADSKRVEAGVQNLVPESSKHDISAASPETANQASSQDTKKDWKGEIDLLIEWFFFCWTMFLLAVYVVARLFIIVEMFRALAYLPPDAYYGTWGSNLPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0Q8</accession>
    <name>A0A317X0Q8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_382123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469603.1">
        <property type="nucleotide sequence ID" value="XM_025607271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0Q8"/>
    <dbReference type="STRING" id="1450535.A0A317X0Q8"/>
    <dbReference type="GeneID" id="37109414"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30375" checksum="7F6138C5AA3FB04E" modified="2018-10-10" version="1">MRVITITSSFRVTIWDVDSWNSLQSAVLPIPQNRRYEIWPATMSPETGMVAFVFTVPTGQKRSIELWDIRSGNHIRTIDSDVDIFKCYISPHGRLVVSGCGRGHGRTGEIWDINTGTLVAEIRGGFVSEISPSGELIATASGGSITLLHTKTRKKMGEIEMRKLKMDGATLSNLTFSRDEQWLCTEKGLVRVASITDPNLGPMGKEITLKEGRECLLEGGKELILLPRGNRPFGLECADPSVAPYHSVALHYPGGSATTIEFDSSEHRTVRDTSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1F1</accession>
    <name>A0A317X1F1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_23549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468748.1">
        <property type="nucleotide sequence ID" value="XM_025606322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1F1"/>
    <dbReference type="STRING" id="1450535.A0A317X1F1"/>
    <dbReference type="GeneID" id="37108465"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016444006" evidence="1">
        <location>
            <begin position="26"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="3">
        <location>
            <begin position="144"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY90370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="377" mass="40053" checksum="33EC842BF653A900" modified="2018-10-10" version="1">MPATPIRTALIGLSASAITSWAADAHLPAIQSPSGQALMQITALCNSSVAAAETAIRTYHLGPATVKAYGNPDDLAADPTVDLVICTTRVDKHYPTVLASLRAGKSVYIEWPITSTVAEVDKLLSVARASGATVAVGLQARFAPPIIKIKEILRSGRLGRLLSTEVRGYGGTGARDVLPTGLKYFAQKEVGGNPITIGFGHMIDYVQSVVGDVIPGTDQVHTQIQRPEVRILDPQTGTFVDTIQTDVPDLLSLHGTLAESPYTVPGASLLACFARSQPYPGDPLLSWTLNCESGSIRLTAPAGISLHGPSTISVHHHASDTVEEIEWTWSKEQSEVPAKARSVQRSLINFAVGNPEGYVSLEDAAGRARQIARWLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X362</accession>
    <name>A0A317X362_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_583239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469757.1">
        <property type="nucleotide sequence ID" value="XM_025615545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X362"/>
    <dbReference type="STRING" id="1450535.A0A317X362"/>
    <dbReference type="GeneID" id="37117688"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031359">
        <property type="entry name" value="NACHT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17100">
        <property type="entry name" value="NACHT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NWD NACHT-NTPase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="315"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="819"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="861"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY92996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="949" mass="107311" checksum="97202D047AABAF5D" modified="2018-10-10" version="1">MRLTGLWDEAYAELEKEHPKLVHFYETDLLAGASDQSEVDLDRQKQLATLVQSKLKTIEAHVGLSLGGSQIVVRDQARKVARMIVGVKDFISAAVSAEPHASLAWAGVLVLIPILLNLITQHDDAAQGVEYISDLLIRPAIELKELCASIRGKTIRLYSEILQYEIRLAKQYSHGASFHALRDFAVADNWKEMLTSVKTLEQSIKTDLETLGDDTAKRIDTTVAEMMVNLKQTRDDLQDLKQAQILQSLPLLRGLVPIPSRTNTNPDAWKGHSSGSSNKFKLGAMSLPKSPSSAFKEWLAQANRPFLEHCIILGGSFFFNHAEYDRNNAKMFFTTLARHLKDSVPDTRMAISEVISRNPGIATESLSNQWKYLILQPLLRLESNLPSPRTLVFVIDALDECKDRNDLETIVQLLSQFTKLKKLRIRVFITSRPEIDIRRAFQQVPKGTLRDEILSKVITMEAENKFKDYITRLLEYELSQVSTKHCLGEHWPGNDKIATLVRKSDGLFIYAATVCRFLGGNNLTKSRVKTRLDMILEDEYAKNSPQKSLDDVYRRILEVSVIGDADEVEERDILGSFRRVVGSIVVLFDPLSTGTLGDLLSIQKSDIEETLEGLYSVVTVPKTGDMPIQLVHLSFPNFFLGDNRCADTRFHIDESEAHRLLFGHCVKAMSNTLKRDICSLRKPGIFKRRMKHLLKVKSDVGFDETEAFLNAHLTHWLEAMSLIGLMREAVSLVIELFEHVSVPQKRVHTELYGFLYDARRFVLNFRAVIEEAPLQVYCSALYFAPEDSIIRSKFWYETPIWIHQFPTMEKEWSSLLQVLEGHRQRVQIVEFPPNDRFIASASDDRTIKIWDSATGAVLQTFEGYREPVICVAFSSTSKLLASGGQDGAVVIWDISLGSLLRTFERKGPITAVTFSTDDKMGAFASDKGIFTWDLREAVVVFALRARKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X449</accession>
    <name>A0A317X449_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannose-1-phosphate guanyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_532319</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="EC" id="2.7.7.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470140.1">
        <property type="nucleotide sequence ID" value="XM_025611097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X449"/>
    <dbReference type="STRING" id="1450535.A0A317X449"/>
    <dbReference type="GeneID" id="37113240"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071554">
        <property type="term" value="P:cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05824">
        <property type="entry name" value="LbH_M1P_guanylylT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000017">
        <property type="entry name" value="Mannose-1-phosphate guanyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="16">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="17">
        <location>
            <begin position="256"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY93379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="364" mass="40146" checksum="C39A556740B28D8D" modified="2018-10-10" version="1">MKALILVGGFGTRLRPLTLTLPKPLVEFANRPMILHQVESLAAAGVTDIVLAVNYRPDVMVSTLKKYEEIYNVRIEFSVESEPLGTAGPLKLAEKILGKDDTPFFVLNSDIICDYPFKELAEFHKSHGSEGTIVVTKVDEPSKYGVVVHKPNHPSRIDRFVEKPVEFVGNRINAGIYILNPSVLNRIELRPTSIEQETFPAICKDGQLHSFDLEGFWMDVGQPKDFLSGTCLYLTSLAKRNSKLLAPNSEPYVYGGNVMVDPSAKIGKNCRIGPNVVIGPNVVVGDGVRLQRCVLMENSKVKDHAWVKSTIVGWNSSVGRWARLENVTVLGDDVTIADEVYVNGGSILPHKSIKQNVDVPAIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X455</accession>
    <name>A0A317X455_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_582798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470175.1">
        <property type="nucleotide sequence ID" value="XM_025615501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X455"/>
    <dbReference type="STRING" id="1450535.A0A317X455"/>
    <dbReference type="GeneID" id="37117644"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="230" mass="26345" checksum="2902C2DF74FE3D52" modified="2018-10-10" version="1">MATPNLPPERKILSKLIDVHGYSHYRLQIDTVIKYLSLKCGTFDEPTLGELKVGFFCFCLPRVEPDETWHEYNIPWLDLTHVEKLSENTFEVTYLPKPTAKPRRAIAKFYPFGRDENLYRQIQLYEELQGTGIAPEYLGNIIEGARVIGFHLEKVEGREASVEDLPARRAVLQRFHKKLDRAHGDVHRRHSIVQKKGVKLISFGKSECCDGAKDQRALEVSSLEGLLAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4D9</accession>
    <name>A0A317X4D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_344485</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470255.1">
        <property type="nucleotide sequence ID" value="XM_025607063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4D9"/>
    <dbReference type="STRING" id="1450535.A0A317X4D9"/>
    <dbReference type="GeneID" id="37109206"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000245">
        <property type="entry name" value="Short chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="289" mass="31190" checksum="8836E298A649813E" modified="2018-10-10" version="1">MSVSFDTTDIAPAPVPVVQDGPCLGSKSRMPEFSLAGKVVCVSGAARGLGLTQAEALLEAGAKVYALDRLEEPSPEFYVIQQRALEELGTELHYRRIDVRDTELLNTAIEAIADTEGRLDGLVAAAGIQQETPALEYTAQDSNTMFEVNVTGVFMTAQAVAKQMIRFGDGGSIALIASMSGTVANRGLICPAYNASKAAVLQLGRNLAMEWGQYNIRVNTISPGYIVTAMVEKLFVQYPERRDEWPKQNMLGRLSTPNEYRGAAVFLLSDASSFMTGSDLRMDGGHAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4H8</accession>
    <name>A0A317X4H8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_583782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469586.1">
        <property type="nucleotide sequence ID" value="XM_025615580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4H8"/>
    <dbReference type="GeneID" id="37117723"/>
    <dbReference type="OrthoDB" id="4509505at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="58" mass="6661" checksum="A3FE731F5123CB32" modified="2018-10-10" version="1">MPLRSPVCDLHSACIAVKVARLFKQQQFLKDRGEWILNHDLSVLEQLDEKDPLSAEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5A4</accession>
    <name>A0A317X5A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469458.1">
        <property type="nucleotide sequence ID" value="XM_025611284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5A4"/>
    <dbReference type="STRING" id="1450535.A0A317X5A4"/>
    <dbReference type="GeneID" id="37113427"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30602" checksum="16ADB4BD0AE1EFA0" modified="2018-10-10" version="1">MANDAKQNADNAANSDAEEGEDVFHDARFPAEEETRLLEESQTIKAEANKLFTASCYDQAISCYDRALASCPNYLDYEVAVLRSNMAACYLKLEDWKASVDAATACINRLDKVIPPSTGAYADDAKGKQQEPSAEDAVIEITGDDEEAEEELKRLQKLDDRKRDVMRIRAKALMRRARAKMQLNGWGNLQGAEEDYKELAGMDNLPPDDRRVVQKALRELPAKINQAREKEMGEMMGKLKDLGNGILKPFGLSTDNFNFVQDPKTGGYSMNFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5F6</accession>
    <name>A0A317X5F6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MSF1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_354919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470597.1">
        <property type="nucleotide sequence ID" value="XM_025607125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5F6"/>
    <dbReference type="STRING" id="1450535.A0A317X5F6"/>
    <dbReference type="GeneID" id="37109268"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="190" mass="21481" checksum="BA51A264E3C76BAA" modified="2018-10-10" version="1">MRVFSSTCTFDYSWEEVSAANWRKYCPWNDKSTHVVAVDTLSRAVDATTGILRTERLITCNQSVPQWVLSLFGGSPTSHVYEVSYVDPSSKKVTMCSTNLTWSNVLNVRETVVYQPSLSNPSSTTEFNQEAKITALCGGWQKIKNKVEEASVERFSQNAKKGREGFEAVLEMSRRVFSEQRELDSNKLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5I3</accession>
    <name>A0A317X5I3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_612428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470635.1">
        <property type="nucleotide sequence ID" value="XM_025616677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5I3"/>
    <dbReference type="STRING" id="1450535.A0A317X5I3"/>
    <dbReference type="GeneID" id="37118820"/>
    <dbReference type="OrthoDB" id="2274698at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018823">
        <property type="entry name" value="ArAE_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994">
        <property type="entry name" value="ARAE_2_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37994:SF4">
        <property type="entry name" value="ER TRANSPORTER 6TM N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10337">
        <property type="entry name" value="ArAE_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="607"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="746"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Putative ER transporter 6TM N-terminal" evidence="6">
        <location>
            <begin position="31"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="629"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114373" checksum="2C4D2D5C0DEEF5C7" modified="2018-10-10" version="1">MHLAPPRGSGKSKMARLLSVFNPLTWRQRLDLDAQSFLIMLKGALPPTIVIAIYQSSAIADITSTIGYLSALISVLSQALTPRAKFMRIIFFDLLSTCVSASLCCLAVFCAVWAREHNIPADASESVRDGFSSDACAVSAVWLIFMIWIANTIRAWRPMELQDPMVAFSIFPCVTITRGGTFTTLSEGLSFISRLLKGFMLGFAIATGVSLLILPITSRGHVFDDIKAYVAQIDTVLQSQIGFVKGTSEVWTGSPGLLERSRTARSMRDMGNNPSSDLESKQKRLTASITKLNALHGKLQSDLLYSTDEIAWGKLSADDLTRVGNLLRSILLPLSGMAMLPEVLDMIVKNEGTRHNNLGSRDNDEEESVKQSELQKFAQTLHDRLAESSQLVTVGLHYVLLAFELVKRKTLEKQYLGHSDEEAAGELLTPLQPNFALQFEREMRKYFSHRKDLTKSLASLEAFSVSEKSNDPTSQTDTRAVTTDPDAKQEFFLILYMGHLQDTLLMATLDLIQFADGKIEDGTMKRSKLILPKLNTIRRWLSLDSTKDSKTAPDRRQSSHVDPSVFAQTEANNFPDPEHLPPANWFEKGSLALRYLSHFIRSEQSVFGFRVAAAAFSVGILAFLRQTQEFFIHQRCIWAMIVIVIGMNPTSGQTMFGFVARIVATAVSLVLSLIVWYIVDGRTPGVIVFLYLANVFEYYFYVKVSQYFGASVIAIVTLNVIVRKLGVEVATSNGQPYYPIYLFGPYKLAAVAAGCAISFFWVVFPYPITAKSTLRKSIGRGLFVLAKFYSCMHTTIELWLTGELGVAEDVSSASYTLERSRHKVFKEEMILLNSLRMHSHFSTFEPPIGGKFPKSTYDQIISQIQRMLTSMALMAQTTQNLDALSTSDSSSQDQPESNDDKWVSRLAAIALQSPGFKSHKITSLLCHLSASVLNSQPLPPYLSTGDTFPLARELQRIDEEMLSIRHVQDPAFSAFVCLEVLRSVVSFTLDNLLRNVKSLVGELSFDFHIQHAAESQRLMSEANTQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5Z8</accession>
    <name>A0A317X5Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_564665</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469708.1">
        <property type="nucleotide sequence ID" value="XM_025614444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5Z8"/>
    <dbReference type="STRING" id="1450535.A0A317X5Z8"/>
    <dbReference type="GeneID" id="37116587"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="483"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY91980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="539" mass="60679" checksum="237E66C20D5FC232" modified="2018-10-10" version="1">MAVIPWNLIHLAIAGYTYFRSTFTVFAILSAITILLRLFYRVALYPVYFTPLKQIPTPSSRSWLTGNHPTFVPEDQFERMRQWNNEVPNDGLIRFYMAGNIERMVVTSPKALSELLVQKAYEFEKPPLVRRSLGRITGEHGVLLVEGAEHKRQRKLLMPAFSYRHIKNLYPIFWSKGIEMVKLIEEDLRRRGNPSDNVIRVATWSGRATLDIIGLAGMNRDFDSLRDPNNELAKHYHKINSVPPTPLEKGIFLIGLIFNSAHLVHKLPFKRNRYIASSSAYIRNVALQMIRDARGSINGEKTHKTTDAVDIISVALSSDGFTDEELLDQMMTFLAAGHETTSSALQWCIYALSKHPDVQTRLREEIRANLPSISIDNPDPISATTIDSLPYLNAVCNEVFRFYPSVPITIRIANRDTSLAGHPIQKGMSIHIVPAMINHDKTLWGPDADQFNPDRWLGPGRANTGGATSNYSFLTFLHGPRSCIGQGFAKAELACLLAAFVGKFQFELEDPNAKLLLREAATVSPKDGVRARITPLEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X647</accession>
    <name>A0A317X647_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BRO1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_532727</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470546.1">
        <property type="nucleotide sequence ID" value="XM_025611183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X647"/>
    <dbReference type="STRING" id="1450535.A0A317X647"/>
    <dbReference type="GeneID" id="37113326"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09236">
        <property type="entry name" value="V_AnPalA_UmRIM20_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="4"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="745"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="823" mass="92294" checksum="B6B9CE8D4212EA64" modified="2018-10-10" version="1">MASNILQIPFRRSHSISLSNAITQYISSKYDQRPDMFAEDLLIIDHLRTEAINVQEPHISGISRLVTYAAQLKWLGGKFPVDVGVEFPWYPAFGFNTSRPISQNNLRFELANVIFNLAALYSQLAFSVNRTTSDGLKQACNYFCQAAGVLRHLRSDILPDLRTSPPEDMDDMTLQSLEQLLLAQAQECFWQKAVKDGLKDASIARLAAKVSDFYADAGDYAVKSNAISPEWIHHMTAKHHHFAAAAQYRQSLDCLEKRKYGEEVARLRDSEACVNEALKESRWINRTVLGDLQGLKTRVTEDLKRAEKDNDIIYLNPVPPKSELKLIDRASMVAAKAPSQVTDAISLLGENGALGQPLFSKLVPYAVHIAASIYSDRRDRLINETIIGELETMTDKLRDLLSSLNLPGSLQALEKPLGLPPTLVSHAEELRQQDGLNRLRKSLEDTATVKGNDHAVYSEGVELLAAERAEDNASRRKYGTDRWSRQSSEEAAQKLYTTSREIEGYFTSAQSSDNLVEQKLKDSEAVFRVLTGTNRDLEMYVPSSRWAALPPEVEREVSRLRGCMSEVSRLESRRKRQAQALKDKARTDDISQALIKETARLEREFPMQAIQASQFEDLFEEQLHLYDSDLEMVAREQQDQDEIATRVREANRAFTRAHTGDASTKERERALQELENGYLKYKEILSNIEVGRKFYNDLAKIVGRFRDDSKAFVHKRRMEASQLEGDISSAAAMATLNISQPLRQQPSYTAPAPVPVPAPVPAPAPQPLARAEPMTPRPQPMAAPQPTRANARPAMTPGIWSPEMGIRFGGGGQWDPSKGVKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6L6</accession>
    <name>A0A317X6L6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_459717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470562.1">
        <property type="nucleotide sequence ID" value="XM_025607851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6L6"/>
    <dbReference type="STRING" id="1450535.A0A317X6L6"/>
    <dbReference type="GeneID" id="37109994"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="648" mass="73062" checksum="2274D03BEF6E478F" modified="2018-10-10" version="1">MGEEGSPNPGTSVEADFKFQNVNPGGPLGPPHAGPISNDHAGDRSASSKNRSSRPAQQSGSRNFEFVLVTDNESRRQVRRHAMRQYMHQRRLDSIARLGTARVPVGGWTSRSLSDSQASETSPVEEIQDEPATKSEKGSPSSEEDRPIPEKPKGPSRLLIPKLHKVKREEASSSPAPHKPKPKALDLQSTPGEGPVRDPFSCYPIPVSHTDHELIQHFVVTYPSMMYKFANSIANNPMMEIFRQFALHDGLPFQAMLAIASKHRAGVEGKTESVQSLTHKMRALRLMNERIQMDSTGQYDGTIYAVATMAVIEKWSKDASIERMHFRGLASMIRSRGGMQGMRFSSPFLEKVLYWVDFSCASKAIVSTSLPWTGSILETPPLEFVDPTVHLAVLHDSATAEDSESLCELFRACEDFLRFFRRLRELERLALDAHCTLVPNTTPRRAKYFSPGTPLYTILTMLPDYDHGIRDIRFIDEYTCMACLFFLAMALYDCYLNSTCLDSYLDWLSKEIKKINPFTNPSITSVLWLFLNNGGFPPNDPGDTGSRCWIVSRMVRIAKRLEWKRHGTIWDRLRQVLIDFIVTQQECALGSHHIDSDALAAREQKRLRDQDSPDYFWNEAQMREDILNLTLSSVTTPSVGDMNMPVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6R1</accession>
    <name>A0A317X6R1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_458656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471075.1">
        <property type="nucleotide sequence ID" value="XM_025607809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6R1"/>
    <dbReference type="STRING" id="1450535.A0A317X6R1"/>
    <dbReference type="GeneID" id="37109952"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF317">
        <property type="entry name" value="ADENYLATE-FORMING ENZYME AFEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="47"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="7">
        <location>
            <begin position="480"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="601" mass="65495" checksum="5DF4319EF0E4DF16" modified="2018-10-10" version="1">MGLWDSCPSVVGNQHHNITTTTTTTSNPNGTYTDLLTFAFRGPVSYDPERPLFIDAENPSRSFNARQFETLVRTLIAGLKAHHVQRGDCVLVHLGNSIIYPALFFSIIGAGGVFMGSNARSQPQELEHILQLAEPKLIITSRDALPTVLSVSADRGILPSQVCLLDESAGDHIAQHLLAGPLAYAAAGAPYLPSSGDGSFINFAHLLAYGENDWVAFNDEHIAKSTPAAMFSTSGTGGLPKAAFMSHHAMVSHHLSINYDVPYEVTRLMSLPMFHMFGALWTHLFPIRYGQPLFVLSRFELTQFVAAVYQYRITETYMVPAMIHTFNRSALPIADYLASLRYVGVAGAPIDAAAMQRFGELLPLDASASQLWGMTEVGVVFQNRYGEQANAGSIGRLLSGYEARLVGQDGNLVLEENRPGELYVRGGGLLSGYKGQSDAKDGQGWFRTGDVAYVSGGVYYIYGRTKELIKVRGWQVAPAEVEAVLLKHPEIEDAAVIGVTSGDGSTELPRAFVVRAKDLTTSRLTSEDVYMFARGQLASYKALDGGVIFVEEIPRTASGKIQRFKLAQMNTYREIVSSLLARFKGTSLQTVGIMHKGRITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X704</accession>
    <name>A0A317X704_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fructose-bisphosphate aldolase</fullName>
            <shortName evidence="3">FBP aldolase</shortName>
            <ecNumber evidence="3">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_320102</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2 3">Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class II fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470876.1">
        <property type="nucleotide sequence ID" value="XM_025606896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X704"/>
    <dbReference type="STRING" id="1450535.A0A317X704"/>
    <dbReference type="GeneID" id="37109039"/>
    <dbReference type="OrthoDB" id="2558351at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00947">
        <property type="entry name" value="TBP_aldolase_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050246">
        <property type="entry name" value="Class_II_FBP_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30304:SF0">
        <property type="entry name" value="D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE SUBUNIT GATY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001359">
        <property type="entry name" value="F_bP_aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001359-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="286" mass="31349" checksum="E2628C7CC9A1E27D" modified="2018-10-10" version="1">MPLQTNRAIPILNHAYENKYGVPAMCCYNLEGILATVRAAEKLRSPAMILLFPWAIHYASGILVHAAAEAARNASVPITVHLDHAQTPEIIRQAANITPGFDSIMIDMSHYEKAENLALTRELVLYCNERGIATEAEPGRIEGGEDGIEDTVDLEGVLTTPEESEEFVDTGIDWLAPAFGNVHGSYGPRGVRLEYERLEGIRERVGGRVRLVLHGADPFDREIFGRCIEAGVSKVNINKVLNNEWVRVVTEGKGKGMTGLIEEATERMQIAVEGCIDLLGSGGRYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X726</accession>
    <name>A0A317X726_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_512511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470118.1">
        <property type="nucleotide sequence ID" value="XM_025609813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X726"/>
    <dbReference type="STRING" id="1450535.A0A317X726"/>
    <dbReference type="GeneID" id="37111956"/>
    <dbReference type="OrthoDB" id="5423493at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="501" mass="54810" checksum="BF832DAA34634062" modified="2018-10-10" version="1">MPRPPTKRNRLTSKAPLAVEQIHQQGLERHGITSTDNPKSPTDTNQDIGGSYQRVSSAQVSDIRRQLKNQTPMARAQDHAIESSPMGERGATGSRPFTRARGYSSTISVVGRKGDTASKVPGTPAFENSMLSNFRRRPRQPSILQMMQADDGSSDLDDDVFLGSLSPEDESTPLNLSRGRPLLVRQAASPSPSLPTSSGGASRKRKLSTEELQVPRSDPEVMEHCPATSPTSHHWQNGPDVFVDYLQALNSPSAFSQTLAPPMSSSPPLSPIHTASMPEMAQPKRKDKPAELATSKKMNLPTATLQDKLLPRRNRPQRKHFGLNDSEAPKDFSDGDRSATGHDDDDDDDELYYLPFKRPPRAQRKQANKNNPAKSTMTALAMQDTADSVGGQTMDGQNSPMQPVVTARQPQQYVNGDKKKMTSGPASLQTMNLDREVQPVDTSPLSSPLSSPPDSEASATESTPVSTLDSHFLSEELRLQAKKFADIDKWQLDFEDVVPDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7B9</accession>
    <name>A0A317X7B9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_614567</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470208.1">
        <property type="nucleotide sequence ID" value="XM_025616744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7B9"/>
    <dbReference type="STRING" id="1450535.A0A317X7B9"/>
    <dbReference type="GeneID" id="37118887"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="12"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="113"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY93447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="418" mass="46317" checksum="DBEFDAB2AFC16B49" modified="2018-10-10" version="1">MTVKESPFTIDNLPYGVISTAETPTPRCATALEEDAIDLSALERDGYFKSIPGFKGEVFSMPTLNKFASLPKETHIQTRAALLDLLSDNDIRKNYAIPLLEVQNHLPMETKNFSDFYCSLEHTRNCSELLSLNLPPSWFSIPSVYNGRQSSLRISGTPIRRPWGVTLDPNRPNDPPAFRPSSRFDFELEMGVYLSRPHPPGEILSISDAKDHIFGLVILNDWSARDIQSFEMAPLGPFHSKGSGTSISPWIIPIEALEGSLCNARPQDPAPLRHLAWKGEEGEATFDIELTARVIRKGKSYTITETNLKELYWTPFQQITHLCSAGEGLSTGDIFGTGTITSDRINDQGEQIGVACLLERGLKRNVLSEASRDGLQFLEDGDEVVMEGWCVNHLTGGKFGFGECRAMILPALADGAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7H5</accession>
    <name>A0A317X7H5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_609942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471315.1">
        <property type="nucleotide sequence ID" value="XM_025616592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7H5"/>
    <dbReference type="STRING" id="1450535.A0A317X7H5"/>
    <dbReference type="GeneID" id="37118735"/>
    <dbReference type="OrthoDB" id="3649348at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="165" mass="17323" checksum="5E027B586CB6828B" modified="2018-10-10" version="1">MSTPTPVILCGAMREVAALIRTLLLPEYNVVYAGHNLSAAEREVPLILSGSPPPPSKLHTQIGSNDFTDPPRAVITGGGYNEERFQALYQACTAAKNGVPPVPFFRTDNGLTDRLAATGEGPAHASAEYPAAVTRRLKEKLREAGVGEGEGRGGCFGFEGGGVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8A3</accession>
    <name>A0A317X8A3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_457162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471584.1">
        <property type="nucleotide sequence ID" value="XM_025607732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8A3"/>
    <dbReference type="STRING" id="1450535.A0A317X8A3"/>
    <dbReference type="GeneID" id="37109875"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="263" mass="28894" checksum="758A8244ED2BE647" modified="2018-10-10" version="1">MTQDTTNPSSTGTAPNRIQYLETTDAYNKWAKVYDTDNNFLQALDTLEMQTLLPHFLHLLGNTFGPDPTKLIDLGCGTGRNTLLLARLASPETEIVGLDASSGMLDVARETIEGNSRVSLEIFDLLQESMDVPVGSTRAAGIISTLVLEHVPPRRFFEAAEKMLRPGGCLLVTNMHSDMGAISQAGFVDVETGVKIRPVSYKHEIGDVVAVAEEVGFRVEWLDGEGVRERMVDERLAGVLGPRAKKWIGVVVWFGVCFRKVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8D6</accession>
    <name>A0A317X8D6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_531805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471624.1">
        <property type="nucleotide sequence ID" value="XM_025610980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8D6"/>
    <dbReference type="STRING" id="1450535.A0A317X8D6"/>
    <dbReference type="GeneID" id="37113123"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="238"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="299" mass="34389" checksum="76425B4FA318D5F0" modified="2018-10-10" version="1" fragment="single">PFHKLVKNSAYYSRYQTKYRRRREGKTDYYARKRLITQAKNKYNAPKYRLVVRFTNRDIITQIVYSEISGDKVFASAYSHELKRYGITNGLTNWAAAYATGLLLARRTLKKLGLDEQFPGVEEADGEYTLTEAAETDDGSRRPFKAFLDVGLARTSTGARVFGAMKGASDGGIFVPHSESRFPGFDIEAEELDAETLRNYIFGGHVAEYMEGLADDDEERFRGQFHKYTEAGVEAGDIEELYTEAHKAIREDPFKKDEDEGEKKTKEEWKAESKKFRPARLTREQRKERVEQKIRELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8Y6</accession>
    <name>A0A317X8Y6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_582156</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471526.1">
        <property type="nucleotide sequence ID" value="XM_025615460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8Y6"/>
    <dbReference type="STRING" id="1450535.A0A317X8Y6"/>
    <dbReference type="GeneID" id="37117603"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 12 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY94765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="462" mass="51089" checksum="25FF118BA26FEC2D" modified="2018-10-10" version="1">MSWLTRTPIYHPYQSLISIFVLWKAFLLLLAILTPGPGYDTSTTLAQWYRDSSDIKGLFPTFLRQVSTRLTRWDAIYFTEAARRGHVFEQEWAFSYVFSKFINLLAAASERTGAFPYEFKESALGVAVAHVAHATSAAVLHGLACTIFPGIQGRKLAFIAACLHILSPAGLFLSAPNAESTHSLLSFTGALLFARSLSVSGISTSIQDGLLVLAGIMYGLSTAARGNGLLNGVILLEEAFRVLYSIAQDFSFAKFRRLAAVGLAGICAGLGFILPQYIAYQQFCANRTLTDEWPSREWCYRAIPSIYSFVQEHYWDNGFLRYWNLSNLPLFALASPVLAILVYSSVWALNVESGLKIPSTTPQDFPTGQLTGRLLRSLAIPQIILAVVLFFCNHVQIIIRLSSGYPVWYIWVATLILDCYPAYPSARKKHLEGRGCGQAIVQYMVIYAAVQGVLFASFLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9H5</accession>
    <name>A0A317X9H5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Yos1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_531057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471910.1">
        <property type="nucleotide sequence ID" value="XM_025610816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9H5"/>
    <dbReference type="STRING" id="1450535.A0A317X9H5"/>
    <dbReference type="GeneID" id="37112959"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="86" mass="9502" checksum="61C05C8A3C6730D1" modified="2018-10-10" version="1">MFFFGLGKLVYVIILLINSLAVLSEDRFLARIGWGRTQGDPAFGATYDTTSVKAKTINLIASVRTVMRIPLIVINTIVIVYELILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAF1</accession>
    <name>A0A317XAF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_531908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470679.1">
        <property type="nucleotide sequence ID" value="XM_025611004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAF1"/>
    <dbReference type="STRING" id="1450535.A0A317XAF1"/>
    <dbReference type="GeneID" id="37113147"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="55953" checksum="14EED40446F18CE4" modified="2018-10-10" version="1">MCSSTGRICDGYQQTIDRRTRASRLRLLSTSPSSVSDTSSTVSMPSLASDLILHTNQIDLTRQERWYLDFFRRSTAFQCSGYFDDDFWLRLVHQVTEAEPAVRHAAIALSALHCNFERTSTGQGTVDSRLPLQQCVKAISSLRQQLAGGGLPSRINMEITLVTCVLFVSFMFLQGDTHSACCHLRGGLKLLKEWKGTDLAGYSTTGAVLMKVFARLQLQWSTFADDVFIETENDRFDVPYMEINDLSLEEPTDNLEKAGNLLVSLGRLVLAPRPSGVTPPGYCTVLDTKRMVILNKLQHWTAELDTSITSRGSTLLLRDNTVLTVLKLWSEIIYIMAATENRLGGSETRFDAFHINFGRAVALAKILLLATPDQSVMPSFSIGMGIIPPLFFCAFKCRDWYIRRESLQLLRSCQRQEGLWTTPGAVLVLERIIEIESKELMPGDLVPESRRIDSIHVNILPDDNKIGLWYRRSGMSLHNGRVDATSGVWEKALLDYQVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAU5</accession>
    <name>A0A317XAU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_133962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472464.1">
        <property type="nucleotide sequence ID" value="XM_025605673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAU5"/>
    <dbReference type="GeneID" id="37107816"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="121" mass="14169" checksum="0618AD13C3ED2DB4" modified="2018-10-10" version="1">MVVLTLVAHKQKRRISPEQEKKTKNKKRRGERERERKQEKGQARETRTIARPEDQIRSDQTSKTRPDQTRQHQPNNSCLLLLYLFSIYLSTTLPVVLLSKSTARILHPALFQPGRWIGLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAX3</accession>
    <name>A0A317XAX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_563279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471478.1">
        <property type="nucleotide sequence ID" value="XM_025614351.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37116494"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF9">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016381040" evidence="4">
        <location>
            <begin position="33"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="586"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="888"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="917"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="943"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="976"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1029"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1137"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1181"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1228"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1259"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1334"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="844"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="554"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="561"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="708"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="806"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1372" mass="150972" checksum="54F12530697BE883" modified="2018-10-10" version="1">MVVYTRISGGSAPSLIIACVALFCACLQTVVAEIDSVFKSRPDLYPPVFTLEHRVPDKLSPGYIFVGPYEASNSGPYIYDDEGNLVWSGWGNSGPGNAHGMHVCKYKGKDHLCFFQGVQQNGYCRGHGVIMDDHYRIVRTVVPGGGMASSDMHEFMPINDGKTALMTVYQQRQFDMSPWNVKSGMGWVMESVFQEVDVETNEVLFEWKSLDHVDPSDGYTWPSHTDTSGTGLDPRSPWDYFHINSVDKNEDGDYLISSRHTCAIYKISGKDGSIIWRLHGARPTFKNINFSFSQQHDARWLSENSTHTLLSLYNNGFNGFNRTHEYSSGMLILIDHRDNTATQLHDYVPPGKNMISSSQGNMQVLENNNVFIGWGNNAYVSEHDEEGNVLLWGYLDKDRIMNYRAQKFEWEGNPTDVPALWTYSQSIDTFSPTTFYVSWNGATRVKFWRFYGATNSTGPFMLVKQVEKRGFETSYSAPYFYQWTYVEAVDVEGKVLGKSRTMFTFIPSVELQSHCGRESCENAPAYGLPGEQGAGPAIPPAGINTVPWIDPGHPEAHFDWGQTGSGSEQGESGSGTLRTAYNNVGWIAPAFGFVVAVVAIYTILRVYRRQHQFSRVKERGSSESLDRAEGSKPWQGSSDQSTESYSVLCTLIHPRRTNAASPMPAPKSGSKGTAGRPSLPSLSLSSSTNNPSSSSAIDTPAATPNPLSATSASFAQSSSKSRNARHTRATSWTSAHDQSGLPSPADFSLSTSQQRRRRESNISLADVSEGSSGRYDDDDDDYSRDNMAVRNTSFDWGPGHARSRSHSYSQPQMSLLQPQELADSSAPRPRPAPVTWMSLPRKGQLALLGLCRVFDFLQIASLQAYMFYQLKSFDENLSDADVSTQAGILQGAFTAAQFATAIPWGRVADAEWGGRKFVLLVGLLGTSLSCLGVAFSTSFAQAVFWRSFGGAINGTVGIIRTMIAENVKEKKYHSRAFLILPIGFNIAALFGPVMGGMLADPVKAYPRLFGPDSSFGGADGVQWLVRYPYALPMLANTIFLSFAAACVAIGLEETLEACKGKPGLGVFSMRILARGIRAVVPSSSPLYHRLPFADYDEEGPLLNRRDIAESYEMEEKATKSTRQSRTLPFRRIWTKNVLCTLLAQAFFDFQMGAFNNLWLLFLSTPRYDANDPASPIQRLPFIFTGGLGMLPQSVGFATAILGVIGMLLQFTIYPSINGRLGTAKSYQYFLTLFPLAYAFAPYIALAPSSAPPPGQANGGWVWFSIIVVLFLQVTARTFTLPTSIILLNNCSPHPSVLGTIHGIGQSVSSAFRTIGPIFSGSWYGYGLEMGMVGFAWWLIALVSVFGCVAAIFVYEGSGHEVFLPGEEEELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB18</accession>
    <name>A0A317XB18_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kif17 kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_449152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470471.1">
        <property type="nucleotide sequence ID" value="XM_025607532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB18"/>
    <dbReference type="STRING" id="1450535.A0A317XB18"/>
    <dbReference type="GeneID" id="37109675"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="218" mass="24145" checksum="7041D46D2867F23F" modified="2018-10-10" version="1" fragment="single">SLASVYNLASALIDLGKFEEAEALHRQALRRKLKELGQDHPSTLTALSDLAGLLQVLGKAGEAELLYRQVIEGRQKILPAGHLNTLESFDGLESALRELGKLEEPEELGRLTLECKVKELGQNHMSTLATLNDLASMLQDLGRLEEAESSYRQALDGREKALAFHHPDTLTSLDGLASVMRDLGRLREAEALYREAIKRTEKGLGWEHPSRLTLCNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBD4</accession>
    <name>A0A317XBD4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_530448</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472466.1">
        <property type="nucleotide sequence ID" value="XM_025610673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBD4"/>
    <dbReference type="STRING" id="1450535.A0A317XBD4"/>
    <dbReference type="GeneID" id="37112816"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="12">
        <location>
            <begin position="68"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY95705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="195" mass="20554" checksum="195BACEBA921E4B8" modified="2018-10-10" version="1">MTKETTPPPTTTDNITTTTHEPPSLPASPLAKRTKPNTTTTEQPIPNMGSNGTPLPPLQVKKLTPTGRAPTRGSAFAAGYDMYSSKETVVPAKGKVLVDTGIAIAVPEGTYGRIAPRSGLASKHFIDTGAGVIDADYRGEVKVLLFNFSDVDFTIKEGDRVAQLVLERIYTPEVVVVEELAESVRGAGGFGSTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBX8</accession>
    <name>A0A317XBX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Phosphoribosylaminoimidazole carboxylase</fullName>
            <ecNumber evidence="4 11">4.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_483652</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2</text>
            <dbReference type="Rhea" id="RHEA:10792"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.21" evidence="4 11"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471878.1">
        <property type="nucleotide sequence ID" value="XM_025608931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBX8"/>
    <dbReference type="STRING" id="1450535.A0A317XBX8"/>
    <dbReference type="GeneID" id="37111074"/>
    <dbReference type="OrthoDB" id="15425at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00130"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000013">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000030">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000016">
        <property type="entry name" value="phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000037">
        <property type="entry name" value="Phosphoribosylaminoimidazole carboxylase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016301">
        <property type="entry name" value="Ade2_fungi/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054350">
        <property type="entry name" value="PurT/PurK_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004679">
        <property type="entry name" value="PRK06019.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609:SF5">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11609">
        <property type="entry name" value="PURINE BIOSYNTHESIS PROTEIN 6/7, PUR6/7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22660">
        <property type="entry name" value="RS_preATP-grasp-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001340">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52255">
        <property type="entry name" value="N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="14">
        <location>
            <begin position="108"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY95117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="572" mass="62408" checksum="6F3F5DB5D7FBA369" modified="2018-10-10" version="1">MWNSRKVGILGGGQLGRMMVESANRLNIQCNVLDAENSPAKQISAHDDHVTGSFKEREAVRELAKSCDVVTAEIEHVDTYALEEISSQVRIEPSWQAIRTIQNKFNQKEHLRNYGIPMADHRELVENTPEELAKVGEQLGYPMMLKSKTMAYDGRGNFCVQMKDDIPEALEALKDRPLYAEKWAYFKMELAVMVVKTKDEVLSYPTVETLQEDSICKLVYAPARNVSDAINRKAQELARKAVAAFEGKGVFGVEMFLLDDDSLILCEIASRIHNSGHYTIEGCAMSQFEAHLRAILDLPIPAQSLEIRQPSIMLNIIGGSAPDTHLKAAESALSIPNASIHLYSKGAAKPGRKMGHITVTAATMHEAETHIQPLIDVVDEIRSQRSDVKTKPQKSGPSKPAPSVAVIMGSDSDLKTLVPGLKLLRDYFGIEPAVEITSAHRTPTYMADYSASAAARGIKVIIAAAGGAAHLPGMSAAHTALPVIGVPVKGSSLDGVDSLYSIVQMPRGVPVATVGINNSINAALLAARIIGSFDPAIQRKVEAYAESARAENMELKGTKLRELGWEKYFEQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC63</accession>
    <name>A0A317XC63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_551900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472947.1">
        <property type="nucleotide sequence ID" value="XM_025613561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC63"/>
    <dbReference type="STRING" id="1450535.A0A317XC63"/>
    <dbReference type="GeneID" id="37115704"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF8">
        <property type="entry name" value="S-TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="92"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="238" mass="26286" checksum="E5D498CC25FF047A" modified="2018-10-10" version="1">MSTPKIILYTNRVCPWAHRAHIVLQELGLPFEEVTIDLDTPREPWYLEVNPRGLVPSLSYNNEIITESGIVAQFLADTHPSHLVPPSNTPEGALQRARIAFFVDTYSSKVSPHYNTALRGATVEERKAAGEALVAAVKKEIEPLLYPGLEGKTHGPFFGGSDKLTLVEVLLGSFLIRLHAFAKEEYDLIDSGLSASLAEVKNFSRWAEATREHPSVKTIFPEQAAVAKTKSKLASVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCA7</accession>
    <name>A0A317XCA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_135216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472502.1">
        <property type="nucleotide sequence ID" value="XM_025605687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCA7"/>
    <dbReference type="GeneID" id="37107830"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="100" mass="11003" checksum="7CDFB345D8DF668D" modified="2018-10-10" version="1">MQGQPGSTPHGNLYPLACCRGARRSPGRRRAKMGYVSLQHGWLTVPKQGRGVSSVEGWLIDRILAALEVFLLLVYSVNPLGFLFILVRLASTPQLLTQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD83</accession>
    <name>A0A317XD83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_506611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472318.1">
        <property type="nucleotide sequence ID" value="XM_025609579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD83"/>
    <dbReference type="STRING" id="1450535.A0A317XD83"/>
    <dbReference type="GeneID" id="37111722"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000115">
        <property type="entry name" value="Cytochrome P450 monooxygenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="528" mass="59845" checksum="3302FE67817DBE32" modified="2018-10-10" version="1">MAISTITATATGLFILLLAYKIVIYPVFISPLSKIPNAHWSAPISPVWIIWKRYMAQNNRTIQAAHEQLGPIIRLAPSEVSVNCVDGGIKSIYTGGFEKHEWYPRVFGSFGTVSMFTMTNNKAHSNRKRMLSNIYSKSFLQSSPHIHLISETIMLDRLLPIIQEAASSGSPIDMHDLNQGLTMDFVSAYLYGLANGSNFLQDESFRRRMLRLYQSRKPFEFYHQEVPNLLSWTKHLGLRLIPKWCDEANEILDAWGLNFCDRADQCLSSTKPGIEPTVYKHLKQSISKQLPLKEQNTASYTKLIEKQRLDIACELYDHLTAGHETSAVALTYLFWELSKHPDLQKSLREELLTLEPKILYPRSSSSRELPTPKSIDSLPLLEAIVTETLRLHAPIPGIQPRVTPSPGCNLVGYSDIPGNTRVSAQAYSLHRNAEVFPEPETWQPKRWLKDSNTPSELEERRRWFWAFGSGGRMCVGSNLALQEMKLAVAAIYTNYTTTIIDDEDIEAIDAYTVKPRGEKLVLKFESVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE38</accession>
    <name>A0A317XE38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_10494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473202.1">
        <property type="nucleotide sequence ID" value="XM_025605477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE38"/>
    <dbReference type="STRING" id="1450535.A0A317XE38"/>
    <dbReference type="GeneID" id="37107620"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF45">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="11"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY96441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="506" mass="55614" checksum="5EDD5852880DAECE" modified="2018-10-10" version="1">MQGQALRYAQILLVACPSFILFGYNQSGVGGLDDFPSWVKVFPEIDTIHTTGAQKSHNATVQGAVVASYTIGALFGSLICMIVGDMLGRRRTIFCGAVIALIGQALECTAYSLAQFVVGRVVLGWGVGMLSATVPVWQSECAPAAQRGRNVVLTGMFIAFGFALTQWVNFGFYQIENSPASWRGSLAIPALFSFIIMGSIFFLPESPRWLVMKNRSDLAQSTLASLRGQGMDSLEVVGELRAYEISLEESSNHTLRLADIFTMGEEKLLYRFILCITLQFFQQMTGGTLISVYIPLIFQTDLGLGASLSKILAACALTWKFLCCFVGFAIIDRMGRRTAFMVSGGGMAMCMLALAVSNSFTNNHTASIISALFIFIYNFFLPIGFLGANFLYPAEVAPARLRVAMQAISIANQWLWMFVVAMITPVAIDDIGYRYYIVYAVIGGIIPPIIYLFYPETKGRSLEEVDEIFRDAPSIFAAVSMSKHLPVGDRILERVMEEKATVEEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEM2</accession>
    <name>A0A317XEM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium and cobalt transport protein and translocase of inner mitochondrial membrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_530032</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473412.1">
        <property type="nucleotide sequence ID" value="XM_025610588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEM2"/>
    <dbReference type="STRING" id="1450535.A0A317XEM2"/>
    <dbReference type="GeneID" id="37112731"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY96651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="364" mass="40799" checksum="3C0CF32C94B8BB08" modified="2018-10-10" version="1">MPSGETPRFSHFSCRTQKVVTSSTWDGLLLNQSAQSSDTKGSENDTWWIDICDATEEEVATVCQALSFHPLTAEDIATRESREKIEAFRNYYLISFQTLLSSNDNDSSRITKSSSSIPGSTGFYILVFKNATVTFSPSGRGHISHVRDRIRRTQDTQMVSSDWICYALIDDIIDSFEPYMRAAEREADAIEDQVFIVRVDDVKSLIPQVDSLRKNITQLTRCLSGKYDVLNGFVKRCQAKNRNPMFPDGDLIVYLGDVQDHLVTTLTSLSHFDEIVGRSQSNFLAQLSVNNIRLSFDINAVLSKVTVLATIFVPLNMVTGLFGMNVQVPGQDDTHNLAWFFSIVGCMLAFVSVACWVAKRLQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF00</accession>
    <name>A0A317XF00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_619448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473058.1">
        <property type="nucleotide sequence ID" value="XM_025616861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF00"/>
    <dbReference type="GeneID" id="37119004"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="113" mass="13180" checksum="3CF1EFDA4F6A0A64" modified="2018-10-10" version="1">MPFESQQEEQQQQQEQQQMVAGPGPEKIPQEEEAAKKQKKQEVMVRFFKAEDRYKESLVELEEAIEARNEAIEAMNRQEEVMAPVDEALRGLEEDIAAIRAEFWELTYGYSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XG01</accession>
    <name>A0A317XG01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_453268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473548.1">
        <property type="nucleotide sequence ID" value="XM_025607556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XG01"/>
    <dbReference type="STRING" id="1450535.A0A317XG01"/>
    <dbReference type="GeneID" id="37109699"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY96787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="504" mass="53836" checksum="BA4240A7F153D423" modified="2018-10-10" version="1">MSLLREAERCFANQGSYAALNALIATLHQSGQWLERVRDADARRTRGAPKSKVDGRLIAFKDNICTRDLPTTCASNALDKFISPFNATVVQQLEDAGAIVAGKANLDEFGMGSHSVHSNFGPVRSLRRNHDAESLSAGGSSGGSAVAVATAQCYASLGTDTGGSVRLPAAYTGTVGFKPSYGLISRWGVIAYANSLDTVGIMGSDVSTVRSVFDIVNQHDPRDPTNLSPPTRSRIDSHLSMLTLASRRTSSLKIGVPLEYNLSELTPSALRAWSRSLAYLRQQGHTLHTVSLPTTKLALSAYYVLAPAEASSNLAKYDGVRYGNRPEGPDNTTSTEGYLYANTRGEGFGSEVKRRILLGAFSLSADAMDNYFIQAQRIRRLVQHDFNTVFRACQPLDSPDLGTKLDSEEAGVDVLVCPTAPSPPPRISSLMGHGTVTSSLEAYMNDVFTVPASLAGLPAISVPVTTDDAQNPENSDLAGIQVIGQYGDDGLVLKVAELLEGKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXA8</accession>
    <name>A0A317UXA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flavin prenyltransferase PAD1, mitochondrial</fullName>
            <ecNumber evidence="6">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">PAD1</name>
        <name evidence="9" type="ORF">BO94DRAFT_338682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Oligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000057">
        <property type="protein sequence ID" value="PWY65628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXA8"/>
    <dbReference type="STRING" id="1450535.A0A317UXA8"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1950:FF:000001">
        <property type="entry name" value="Flavin prenyltransferase UbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004685">
        <property type="entry name" value="PRK06029.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="8">
        <location>
            <begin position="42"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY65628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="227" mass="25002" checksum="A14F34BF2F84061A" modified="2018-10-10" version="1">MFNSLLSGTATPNSGRASPLASEMTNEHDQVAVARPAPRRRRIVVAMTGATGALLGIKVLIALRRLNVETHLVLSKWAEATIKYETDYHPSNVRALADHVHNINDMAAPVSSGSFRADGMIVVPCSMKTLAAIHSGFCDDLISRTADVMLKERRRLVLVARETPLSEIHLRNMLEVTRAGAVIFPPVPAFYIKAAGIEELIDQSVGRMLDLFDLDTGDFERWNGWEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXQ0</accession>
    <name>A0A317UXQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_540863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000059">
        <property type="protein sequence ID" value="PWY65282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461407.1">
        <property type="nucleotide sequence ID" value="XM_025613006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXQ0"/>
    <dbReference type="STRING" id="1450535.A0A317UXQ0"/>
    <dbReference type="GeneID" id="37115149"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="239"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY65282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="697" mass="78826" checksum="66B227BA4E3E63D6" modified="2018-10-10" version="1">METSVSELVERLGSDEDAVRKMAVFKLQGSIGDPSFADIFIAEGGLAKLRYLTIHASGNTLAYSLTSFARLLEVDKGWDLVDQEVVERVVELIVTHPLVNILRGAMSILVSTVSHPYTGNHLSQDGNFGFRALKPAIAIYPQFLEMLVNRLSSADHALCANALQLINSLMRDSITNELDTEWPKFIQKLQDLGVIRAVYSLMQGTALQDHMHPLIEFQSLTKVLIKKWKEISLDSERPEHRRALKGIYLASSHERSQDKGVENSDDVRHTKRHNPEKWRRLGFETESPSTQFEDTGFLGMMDLADYVRNHQDEFQKMLLEQSTKPTQQRCPIARASLSVTLILYQHFEVDKSEMDDAKGYLLLESRSNLDMLFEPLLLHWTRLHVAGLHAFFRLWKATGAEVEDYGKLVELVRILIESVVGGAPRTKDVQEVEEELANFEYGRLRELQMELLELTYEDAWGQHLRQMREELYHEALQFVKEQRIRCLLQGAWFPNESPHSSEAVNEKFSWRYTQLSHNRRFLHFGDFSAVEENCPELDALPEKIDLSLVSSVVSNVGASSKDHTVSSAKDMAHAISFTKITVHGYPSPAPTNGDTRKNNGHRRTSSKSAHGESVLLSLCPPSPSVASEWLDGLLMLLNQQPITAETNKLLDSVSNYGLKIRLLNVRFDDVAFAGDAPQVPSRDGLDDNYYYDVFGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYG3</accession>
    <name>A0A317UYG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_528486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000050">
        <property type="protein sequence ID" value="PWY66795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461731.1">
        <property type="nucleotide sequence ID" value="XM_025610423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYG3"/>
    <dbReference type="STRING" id="1450535.A0A317UYG3"/>
    <dbReference type="GeneID" id="37112566"/>
    <dbReference type="OrthoDB" id="2796951at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016407461" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="379"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY66795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="485" mass="50954" checksum="F061A2C1FA5DEC2A" modified="2018-10-10" version="1">MAGIRLNALIVPALLLVAGSVVNGLSFEIPSSAPANASGQLDATPVGLSFEFFAFPEYFQQLPLTNSCLGQLHDAAGAYSPIRIGGTTQDRATYNASLLSAVSYSVDSPDDAPETLTFGDSFMDIAAAYEGTVTLGLNRRLDNVSNTIAAAKIAKSRIANLYAIELGNEPNFFTSSDPIADGHAWTAAADAASQVSWQASVSAGLDDETSFAQAGVFFGLGSFDVSNLAEKEEDTDSTQYVRSFCHHYYPQSASTADLDGLMSHTEIVEGLAEFQAQVVTAQDLNKDFVFGETNSATGGGGGISPTFGAGLWILDYVMQATILGVKQLFFHQGTIGNCPYCWWDESVNAPFYGAYTAALALSGASKIAELDTGDGRFAAYVFYDSDDQPIRVLLYNSEYYTSGTRSSVNVTLSSIPSTSSSVSAIRLTGDAATTIVGEGAITIAGQTFANGTCELQGTKDTEKIGTTAGVATFAVQASEALLIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYM2</accession>
    <name>A0A317UYM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_629143</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461548.1">
        <property type="nucleotide sequence ID" value="XM_025617538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYM2"/>
    <dbReference type="STRING" id="1450535.A0A317UYM2"/>
    <dbReference type="GeneID" id="37119681"/>
    <dbReference type="OrthoDB" id="5403280at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF52">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="47"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY66038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="494" mass="54213" checksum="20704A302D41B384" modified="2018-10-10" version="1">MDELETIKPPIPTEAPSNNPDILTVTWDGSNDPQDPFNWPLNKKWRATALGLTASFICSMNGTIITVAHQAISDEFHISDTTFPNSYWPTTSWGIGAALCPLFLFPIMEDFGIRPVLLSTYFLFICLLIPIGLAQNFTTLITVRFFSGGCVPLISDAVASIISNVFHGDQARSTPISLYVTTYLVSTSIGPVIGSSILQYLSWRWIAYLESIWTAILFPILLIALPETRESAILLTKAKLLRHEGKQAYTASELNQTPLLQTITTSIQRPLYMLFTEPVVFIAALWAAFSLGTIYLFTQSVEQVYTTLYNWTTIQTGYIQIAIVIGELLGCVLSIIVTNHFSSTPTPHNKQPNPETKLYPSIIGGFFGVTAGMFVYGWTSYPTIHWIAPTIGLGMVGFGTTAVIIGNANYLIDAYSKYAASALGAVGLVENISIAFLPLAATAMYSGLGFQWASSLLGFVSLGLVAMPFVVMRWEVEIRARSLFMKEAVIDRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V061</accession>
    <name>A0A317V061_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative NRPS-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_307454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461992.1">
        <property type="nucleotide sequence ID" value="XM_025606803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V061"/>
    <dbReference type="STRING" id="1450535.A0A317V061"/>
    <dbReference type="GeneID" id="37108946"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="521"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY67643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112575" checksum="1E330D05D91E620C" modified="2018-10-10" version="1">MEKILINHARDAPDAVAVIDQGRSLTYAELFSESNHLSERLKAEIDPGSTIGILLGPGVKQVVAQFAVRLADCVCVPIEPSVPKRRLTDILQDAQVKHIIMEDGQLELPDSNRFDFDIGQSQLGTKFQNPPVDITSEHSHILFTSGSTGRPKPVQIRADGILHLATETPATPLSCDDRVASFNNPGFDLSLFEIWVTLIARATIVIVPRRIATDPGAMPSFLQENEVTVLIITAALFNIMASDQGAFHTLKHVLTAGDVANVRAMREVLEHAPPAHLWNTYGPTECTTLATMLEVTLEETKRDRIGIGGPVGQMEVFLIDHNENPIHQSGQPGEICISGPQQTRGYLNRPAENKKCFLCKPRKELVPGKNEMRNHETVRLYRTGDIGEWRPGSGNLDFVGRSDTQVKHKGFRVELGEVERVLHSCEAIRGAVVIQQPPQSDEGMPVLICFVHLKPSSQFGPENILDFARDRLPSYMVPEAVEIVAEFPLTPHGKVDRKALLETRLKRLDHKASDDGPNGTSHVQEQRAMIHDFCKEILGVADIHDHDDFFQRGATSLQAAALLALIQDQLGCSVSMEDLYCHSTVSDLVHLVGQVASPTDAPDHTRQWMEDINQVDQIEVMPHWESASEGKVFLTGATGFVGAHLLHHLLNRPMVKQVACLCRPRAHPSAADRIQKALERYDLWKSCQDKKHKLFMIEGDLTQDQLGLGPDRYDWLANWTSIIFHLGAKVDFCQSYREHYASNVVGTCNILQLAAAGRRKGLQYLSSIDAWGPTGFVLGTKELYEDGPLEPHAQALRYDLGYAQSQWVAEGMVRRMRARGLPIVIHRPGFIIGHGGTGESNPDDFVSRLIVGCIQLGVFPRLDQRLEYVTVDYVIAAVMHIAASPQCLGHSYSLLSPDQRQSATLQDTCRIINEAGYRVRLIDYKDWVQEVAAKQQRDGPLAPLQPMFRERVLGDLTRWEASQRSPRYRCDKTVQALQDRPDIRYQPFDAAMLQRFIAFWNRKGFYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0F4</accession>
    <name>A0A317V0F4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_614146</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000056">
        <property type="protein sequence ID" value="PWY65660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461487.1">
        <property type="nucleotide sequence ID" value="XM_025616723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0F4"/>
    <dbReference type="STRING" id="1450535.A0A317V0F4"/>
    <dbReference type="GeneID" id="37118866"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF189">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016308773" evidence="7">
        <location>
            <begin position="19"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY65660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="622" mass="68513" checksum="AAB550B1F7013F14" modified="2018-10-10" version="1">MTALKVISAALLSGLVLAQYPPTPEGLTTINSEILPGVTITYKEVPASICDSASASYAGYVNFPQNAMKDAIQDFPVHLFFWYFESYSDPKTSPLSIWLQGGPGGSSMFGAFTENGPCNVAEDSQTTRPNEYAWTKYANMLYIDQPVQTGFSYDILTNGTLDLVSGNIIPDCSTQGPLNKVGTFSSQTLTYTANTTANAARHLWNFAQVWLQEFDVYKSKSQNDRVSLWTESYGGRYGPGFAAYFHQQNENLNSRRDTFKPINLDTLGVINGCIDLLTQETSDPEYAYNKNTFGITAINESQYDAAIEAYSRPGGCEEQIQNCLQLAKEKDPDMYGNATTVNEACFDTSTYCQAEVEAAYIFTSKRGFYDISHCNLDPFPPNYFIGYLADDKIQQALGVPVNFTLLSNTVGKAFNETGDYPRRDRLGYLADIAYLLESGAQVALLYGDRDFACNWVGGEQASLDVQYKSSLAFQSAGYANITSSSAVWGQVRQYGSFSFSRIYQSGHMVPSYQPEAALEIFRRVMDGKDIETGQFDVTTSYSTNGTAESTHTDKVPDAPEPTCYLWSLSGTCAKNQIDAVADRTAKIENYVITDPEQPSDACPYTPTPGNSLVLNFGRSLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0P9</accession>
    <name>A0A317V0P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS drug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_570239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461636.1">
        <property type="nucleotide sequence ID" value="XM_025614787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0P9"/>
    <dbReference type="GeneID" id="37116930"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY66372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="573" mass="61034" checksum="15E294B36A06E839" modified="2018-10-10" version="1">MAVIAEQEAPPGSYQEIGGEYNLSEHAKHAESKDAPADTAENDFPADHQSKQRIAVVMTALSLCVFLAALDITIVSTALPEMVAHFKASDSAYTWIASSYLLANASCVPLWGRISDIWGRKPILMTVVVLFLGGSLICGVAINTAMVIAGRAIQGIGSGGITVLANICVSDMFNVRRRSAYLGIFGATWAIAGAIGPIIGGAFTTYATWRWCFYINLPIGGLAFFGLLFFLQLDTAPLTPLKTGLLSLDWIGLALIVGATLMLLFGLELGGSLHPWSSATIICLLIFGALTAGIFLVYEHRFAHIPIIPTTLFSNSYNLIILLINFCHSTVFLGACFYLPVYFQNILLASSLLSGVYLLPLVLALAVSSGLAGFVMRTTGRSREAIILGMFLTTLGYGLLIDLPATTSWPRIILFQVVAGLGIGPNFQATLIALQANTTPAEMNRGTGTFSFVRQLAAAVSVVVGSVLYARAADGQRSVMAAVLGDTVAQEIVEASTAAAAIVETLPVGEKRVVVFNALTAALRWVWVLYTGVAGVGFLISLCLRDLRLGDAHQRPKKEMDEGLKMEGGSMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V1D5</accession>
    <name>A0A317V1D5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KH domain RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_303838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462115.1">
        <property type="nucleotide sequence ID" value="XM_025606766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V1D5"/>
    <dbReference type="STRING" id="1450535.A0A317V1D5"/>
    <dbReference type="GeneID" id="37108909"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="106"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="189"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="393"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY68093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="469" mass="48853" checksum="4FD42E566020307D" modified="2018-10-10" version="1">MSASPSALQSTKRPLEDPSSPSGPNDQPEAKRPALDKVVKGDESEAYADVKTDAPAATADGQGDTVVPDAPSSKGVHVETQPIQSTASHGESANQSDQHRPQDESSWIHIRAVISSQEAATVIGKGGENVSQIRRLSGAKCTVSDYSRGAVERILTVSGPQDAAAKAFGLIIRTLNNEPLDAPSTAQSKTYPLRLLIPHILIGSIIGKGGSRIREIQEASGARLNASDACLPLSTERSLVILGVADAVHIATYYVAVTLVEQLTERFGGPAASAYATRSGGPAGAVPGGMQVVPYVPQPAGGQYGHPDTFKRHHPHPNRGAAGGYGVPYLQGGPAAPTPVAQPSMHYGTTPHTPYAGAGPHQPAPYGAPQAAAAQARGGPTPAAPVGGVMPGQPLTQQIYIPNDMVGAIIGKGGAKINEIRHLSGSVIKINEPQENSNERLVTITGTQECNQMALYMLYSRLESEKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V1V9</accession>
    <name>A0A317V1V9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminomethyltransferase folate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_307226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461978.1">
        <property type="nucleotide sequence ID" value="XM_025606799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V1V9"/>
    <dbReference type="STRING" id="1450535.A0A317V1V9"/>
    <dbReference type="GeneID" id="37108942"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032503">
        <property type="entry name" value="FAO_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16350">
        <property type="entry name" value="FAO_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase central" evidence="6">
        <location>
            <begin position="381"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="4">
        <location>
            <begin position="438"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="5">
        <location>
            <begin position="747"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="827"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY67629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="850" mass="93009" checksum="5571EDB787B98FBA" modified="2018-10-10" version="1">MAQAQRVVIIGAGIVGTNLADELVARGWRDIVVVEQGPLHLPGGSTSHAPGLVFQTNASKTLTRFARYTVEKLRSLEEDGMSCFNSVGGLEVATTPARLDELKRKHGYATSWGIEARLLTVEECLERYPLLNKDLVLGGLHTPTDGLALAARATQLLIARTQKAGVRYLDSTPVTAIEQTGSRVTGVTTPSGTIPADIVISCAGFWGVEVGAMAGVAIPLLPLAHQYAKTTAVPALAGRDTNELPNGMNASLPILRYQDQDLYYREHGDQIGIGYYGHRPMPVVAASLGQTPKHVDENQMPSRLPFTSEDFATAWTMSQDLLPALRESQVKDGFNGIFSFTPDGGPLVGQAPNLDGFYVAEAVWVTHSAGVARAMAEVLTDGASTIDLAECELSRFEEVQLTRAYVSETSQQNFVEIYDILHPLQPRESPRQLRVSPFYSQQQQLGAYFLELSGWERPYWYEANAELLQSLPAEWQPASRDAWSSRYYSPVSAVEAWKTRNAVAMYDLTSFHRVHVSGPGALPLLQRLTTGDVTAPPGAITYALILNDQGKICSDIFIARLEKDIFQIGTNSATDVAYLVKEARHQGQHIPSQWVQVSDVTGSTCCIGLWGPRARDVIRAVTTDDFSSAALPYMSVKRATIAGIPTTALRKSYVGELGWEIQTSAESGHLLWDALWQAGRPHGLVAAGRSALNALRLEKGYRTWGSDMTTEHDPYEAGVDNAVRADKQEDYIGKTALEARSRQKPVRRLRCLTVDDGHSMVLGKEPVYHNGRPSGYVTSAAFSYKARKPAAYAWLPGWVQEGEAVVIEYFGKPIKATVTAEPLYDPRGSRLHREGPSVSSELERPPKQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5F7</accession>
    <name>A0A317V5F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_527660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462184.1">
        <property type="nucleotide sequence ID" value="XM_025610395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5F7"/>
    <dbReference type="STRING" id="1450535.A0A317V5F7"/>
    <dbReference type="GeneID" id="37112538"/>
    <dbReference type="OrthoDB" id="3057599at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="672"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="709"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY68521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="824" mass="92238" checksum="BCD7818114691969" modified="2018-10-10" version="1">MLAPGSGNVSLRTVSSSRPQLMHSQSQQSVAASDDYYSFSSPSSSARSRASGSRITVARYATPNSHPPTRTPSPSVSRTHLAPPPGARSEHSLSAPSESRNFATPASRTIRTVDERDTEPSHMSDTTSRREPSDSYAGRPTTPGLDDSPYIHFAISQLTRDEEVAGPRRRSSVTSNDNPLEPLLWDEGLGCFIRSPGPSTTPVRPPQQSSDSIGRAAQSSVDPESFVAVEPPEDSLLYPPLDYVPVVLRTWALAAIILCCLLMIAGISFCNVWSQRHPGLWDYTGLGGSHYFVMQFLPQILGMIITIWTFVIQAALYRTMPFAIMASERPFGYVLQNLPILSQNFLIPDFSHFRHGEAIVGFSLFTMWLSNVITLPLLSCLFQAKWYSIDGEGTWRWASVLEVGWTLVAIYALLAIGLILLMFRFVRTWSGLMWDPVSLADLISIIQRSNILHDFEQSETLPDVGESLDPRLLRLGYWKLSSRAETFYGIGEVDAPVRTPSLHRKEKNLQMQSHGLSRVSFDLEQHDLTEKEEYYQHLYSPAIRYRWVPWFLRDGFVILWTVIVGALFIAFVLVSFIHDAIKGGFPPRLPTLPSTGAFSSSNFCYSFVPALIGNIFFLAWQPIDVYFRALQPFATLSSPNGARAEHSLLLSYPSYYPFQVTILALLNKHYKVAWISFMSTISAAIPILAGGVFIALYHPSDDAIRISALMPAFYTMVAFCALYMLSFLCIWPRRCRRLPHEVNTLADQMSFLYQSPLLADKILREPRSKADLVTRLVVAPPGDREHSMYGFGIYVGRDGKEHLGIDRFDRPGRADMLITTGCMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6Z6</accession>
    <name>A0A317V6Z6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_300289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462346.1">
        <property type="nucleotide sequence ID" value="XM_025606739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6Z6"/>
    <dbReference type="GeneID" id="37108882"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="1">
        <location>
            <begin position="302"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY69031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="718" mass="81255" checksum="53F1E2BCED85CAF7" modified="2018-10-10" version="1">MFRWYKRAGKCYAYLNDVSPSADREQLYVNMKRSRWFERGWTLQELIAPSDVMFLAKNWTEIGCRKSLSALISEITLIDESVLQGDSHLQRFSIAKKMSWASGRVTTKREDIAYCLMGIFDVSMPLLYGEGDKAFIRLQEEIMKDSDDQTLFAWENSAVSMDHPSGLLARSPMDFRNSGNIIPFKFSKATMPFSVTNRGIRLDLPLLRAPDVDVQEADTWTPGVDILALECRDASNSFFPKPVGVKLRQKPGGHSQFLRVHPSLERNIHLSQLYYTRSTTIYAEKTMTREYVELPRMRRQNRNLILCLDGDNSQNFKTGTRSNIQLIHELVGDTDDLQNCYYGEVGGSGSEHVQLCVMRAYQVSYISPLIAATFPARLTPFIKWLARKYSDKYDIFIFGFASGAFAAQVLAQIVDNVGIFQVSYVSNHPERIWDIYEDWYRAVIGGEGGDEWEYEDTASSLLRINKMRTKYSELTDRVTFLGLFDTAMATSDLGVRLTFHTSWGRHRNLPSEISHPALIVRHAVALDERRIALHPILVGEPMFEGIQDVEQLWFSGSHADIGGIAYSANNLPVAGEKGGNLSLIPLVWMICEAAKAGLTFDQGALRQLFGGNPQKTIKAALDNDGDHIIYSVVPSDRLRETWYRIATVANKHQEDQSLLSSMSEFAMSPLPYLKVYLQAFAMEGWPPCFTGELSLPVVPCIAQFFTGWTNTRTIVRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V825</accession>
    <name>A0A317V825_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_478167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462287.1">
        <property type="nucleotide sequence ID" value="XM_025608680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V825"/>
    <dbReference type="STRING" id="1450535.A0A317V825"/>
    <dbReference type="GeneID" id="37110823"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF7">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY68972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="586" mass="64781" checksum="87FB4B2585A1AB63" modified="2018-10-10" version="1">MDKGKSTWQKAAEAKRQAILEAIPPKWRVQHLTPPNDVTGTYIQRFLNPREIEITEADAVSITTQTNSRKWTAVEVTEAFCHRAAIAHQLVNCLHEIFFEDALKVAKELDDHLAATGKPKGPLHGLPVSLKDQFHVKGVDTTMGYVGWIGTFQGRKDDSRARVVESELVRELRNLGAVLFCKTSAPLTLMSGETANNIIEYTYNPNNRLLSSGGSSGGEGALLALRGSPAGFGTDIGGSIRIPAAFNGVFGLRPSAGRMPYEGAANSIDGQNTILSVIGPMATSVESLRLLFKAVLSQKPWLHDPLALPLPWRNDIDMKTQKLIEASARDPSLLAFGIMPHDGVVHPHPPVEEAMTFIKDILQDMGHRVIDWTPELCKEGQIIADKAYSMDSGEDLLSHIALSGEALPLQSFIGKSKHFNAGEVAELNVQKREYMKKYMDYWNRTNDMTATRRPVDAIICPTAPYAAVIPGKFCHSGYTTFINTLDYTTVVIPITFADKEVHTAEDPPQFFNQLDQKVYSEYNAEIYHGAPVGIQIVGKRYEEEKILALAEYITRCVKMYSDEDLEGSNSGCHGIDSSLLSRQRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8G6</accession>
    <name>A0A317V8G6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="5">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_527249</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Endo-1,4-mannanase, a crucial enzyme for depolymerization of seed galactomannans and wood galactoglucomannans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462497.1">
        <property type="nucleotide sequence ID" value="XM_025610378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8G6"/>
    <dbReference type="STRING" id="1450535.A0A317V8G6"/>
    <dbReference type="GeneID" id="37112521"/>
    <dbReference type="OrthoDB" id="406631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000076">
        <property type="entry name" value="Mannan endo-1,4-beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016337993" description="mannan endo-1,4-beta-mannosidase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="12">
        <location>
            <begin position="34"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY69669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="378" mass="41182" checksum="5D7F4AB43CEC9390" modified="2018-10-10" version="1">MKLSNSLLGLTSLALANLATALPKTTPLPRSTSSFSSTSGLQFTIDGETGYFAGTNTYWIGFLTDDSDVDLVMSDLKSSGLKILRVWGFNDVTTKPSDGTVWYQLHENGQSTINTGADGLQRLDYVVSSAEQHDIKLIINFVNYWTDYGGMSAYVSAYGGSTETDFYTSTEMQAAYQTYIKTVVSRYSNSSAVFAWELANEPRCQGCDTSVLYDWIESTSKYIKSVDSEHLVCIGDEGFGLDTGSDGSYPYTYGEGLNFTKNLGIETIDFATLHLYPDSWGTSDDWGNGWISAHGAACEAVGKPCLLEEYGVTSNHCSVEKPWQETALNTTGVSADLFWQYGDELSTGESPDDGNTIYYGTSDYTCLVTDHVAAINSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8M8</accession>
    <name>A0A317V8M8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Small nucleolar ribonucleo protein complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_540084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462407.1">
        <property type="nucleotide sequence ID" value="XM_025612834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8M8"/>
    <dbReference type="STRING" id="1450535.A0A317V8M8"/>
    <dbReference type="GeneID" id="37114977"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000549">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="574"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="198"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY69202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="602" mass="66476" checksum="46D7E2F5A1F5D700" modified="2018-10-10" version="1">MPKAGVKQKTRQTVKTAARSPFEPGQPIRNDDIEMDDETSSDESDVPEKDDAERKLEAMLFGDDEGFLGALKNQNERSLALADNSDEESAEDGDENEDEERDLAELDDADLFFLDSGAGPVSTELTEAPAMPSDGEGSDEEVGMPALWHDSDDERISISLASHQRLRKLRVAESEDVISGKEYIRRLRRQFVQLNPTPDWADVEKNQQKNDSNAENMDTDDEESSSTQPLAKLLQSATDLVKLEDKTAPGSRRKLRQEVVDIQRLKDVGKDQPSSVDSLMFHPHYPLLLSSGPAATLFLHHISPSSPAPNPLLTSFHIRNTPIHSSAFHLPTGSRIFASGRRRYFHIWDLETGKVDKVNGTADRKEEQKSMERFKLSPCGRYVGLVGSSRKGGGLINVLDSGTAQWIAQVRVDGRGGVADFAWWSDGEGMTVASKNGEVSEWDGRLNRVVARWMDAGAVGTTVLSLGGRSGRTQLGGDRWVAIGSSSGVVNVYDRREWAAAYAADPNQAIPRNPEPVRALDQLTTPISHVVFAPDGQFFVMASRWKRDALRMVHLPTCTVYRNWPTSNTPLGRISSVAISPNSEHLAVGNEQGRIRLWEIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBN5</accession>
    <name>A0A317VBN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_628344</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462653.1">
        <property type="nucleotide sequence ID" value="XM_025617478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBN5"/>
    <dbReference type="STRING" id="1450535.A0A317VBN5"/>
    <dbReference type="GeneID" id="37119621"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="548"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="199"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="415"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="732"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="868"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1059"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY70362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1262" mass="144225" checksum="3FC97E66E0F8CC8D" modified="2018-10-10" version="1">MGKLIRLELYNFKSYKGHHVLLFGDAYFTSIIGPNGSGKSNSMDAISFVLGIKSSHLRSTNLRDLVYRGRVLRTSKVDASGNAIETEANGDDQVEDGIDGEQSQDPSGSNDPRTAWVMAVYEDDAGEEQQWRRSITSAGVSEYRINNRIVTAQQYNEALESENILIKARNFLVFQGDVEAIASQSPKDLTRLIEQISGSLEYKAEYERLKAEAEEAAEQQTVQLNRRRGINSEIKQYQEQKREAENYARKAEERDQAIITHILWKLFHFQRLIDASSADIQKYQDELKEYRRGVEKYEKNVEDAKKDHARVGRDVAKAEKNIVAKEKEIEESTNALVPVDEKVDITKKKVERFSSRIAEITKEREGQAANAKQLEKDLKVVEKAQAQWEAEWQKTMSKQGGQLSEADLQDYKRLKEEVNKRSSAEQLNLDNLRRQRKTEAEAYNSLKSKFEGTEWQLKTLESETQTLAERKSSITDTVKTTSKEIERKKKELNALTSERLRVSQMRTELEEKLQVVLKKLLEADDGKKQSERELRAKELISTLKRIFPGVKGRVSDLCKPKQKKFADAVSTVLGRHFDAIVVDNEKTAKECIQHLRDQRAGQATFIPLETIQVKAFNSNLKGLHRGMRPAIETVDYDESVSRAISYACGNAIVCDDLATAKYLCYERNVDAKAVTLDGIVIHKGGLMTGGRGPQQNSKRWEDSEVENLYKLKDKLLADLGNLPKGHRRGTEEETLQGELVGLEQRLAYAREELKALERNLESKRSELDFVKRQLEEIRPKYVERQEVLEELDQTIATSQETVSSVEDEVYRKFCKRLGYSNIREYEVQQGSLQEEAAQKKLEFTTQKSRIENQLSFEKQRLQTTADRVAGLQAQHQRDEELIEELEAEQETIRNQLDEFNAELDILREKLEKQKEAYAHSAENLAQHRRELQKRSREVEGTIKNVNALEAEIQRNSSSRYALLRRCKLEDIDIPLTEDSESLDQLPIDELVQAADPDAMDVDEDANSGGGEAFIVQDYGIEVDFDSLGDTLKKDDDKAEDELLETVRSLNSDLDKMTPNTRAMERLESVENKLKATEKDFEESRKHARKTKEDYEEAMRKRSDLFNKAFTHISEQIGPIYRELTKSTNYPLGGQAYLDIEDSDEPYLDGIKYHAMPPLKRFRDMEHLSGGEKTMAALALLFAIHSYQPSPFFVLDEVDAALDNTNVARIANYIHDHAAPGMQFIVISLKNGLFQNSEALVGIYRDQVENSSKSLTLDLRKYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDY4</accession>
    <name>A0A317VDY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine gamma-lyase</fullName>
            <ecNumber evidence="4">4.4.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Gamma-cystathionase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_525434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463280.1">
        <property type="nucleotide sequence ID" value="XM_025610308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDY4"/>
    <dbReference type="STRING" id="1450535.A0A317VDY4"/>
    <dbReference type="GeneID" id="37112451"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004123">
        <property type="term" value="F:cystathionine gamma-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000043">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000008">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF15">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY72506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="412" mass="43700" checksum="5B9C178E69B03414" modified="2018-10-10" version="1">MVGHSEFPSQNGASAPQDRRFGTLAVHAGAPHDPTTGAVIAPISLSTTFAQTTVGNPVGLYEYTRSSNPNRDHFEQAIAALEHAKYALAFSSGSATTAVILQSLAAGSHIVSVSDVYGGTHRYFTKVASAHGVHVTFSPCIELDVEELIRPNETKLVWIESPSNPTLGLVDIEKIAAVAHRHGILVVVDNTFLSPYVQNPLDHGADIVVHSVTKYINGHSDVLMGVAAFNSDSLKERLGFLQNAIGAVPSPFDCWLAHRGLKTLHLRAREATTNATAVAKALEASPHVISVNYPGIDSHPHRAIAIKQHRQGMGGGMLSFRIKGGQEAAHLFCKYTKVFTLAESLGGVESLCEVPSSMTHAGIPKDQREAAGVFDDLVRMSCGVEDAEDLLADTLQALEKAVAATKVGNGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VH58</accession>
    <name>A0A317VH58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_539174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463275.1">
        <property type="nucleotide sequence ID" value="XM_025612645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VH58"/>
    <dbReference type="STRING" id="1450535.A0A317VH58"/>
    <dbReference type="GeneID" id="37114788"/>
    <dbReference type="OrthoDB" id="3724345at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="entry name" value="dinb family like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018531">
        <property type="entry name" value="DUF1993"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922">
        <property type="entry name" value="BLL2446 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36922:SF1">
        <property type="entry name" value="DUF1993 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09351">
        <property type="entry name" value="DUF1993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="DinB/YfiT-like putative metalloenzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY72501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="168" mass="18885" checksum="ED3BFAA94DDDADC9" modified="2018-10-10" version="1">MGYTFYDGTIAVIQSILNSLSHILRQAEKHPDATSLLEARLYEDMYPLTDQIRLATQFSENVAAKLTGRDPVDFEGKPTTYAECYERIDTVLEVLGKADKDVVNQQCDIVGPSKVSREMTMEVSGAVYAHTMAMPNIYFHLTTAYDILRKEGVPLGKRDYYAGFFPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHA6</accession>
    <name>A0A317VHA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_232084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463498.1">
        <property type="nucleotide sequence ID" value="XM_025606303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHA6"/>
    <dbReference type="STRING" id="1450535.A0A317VHA6"/>
    <dbReference type="GeneID" id="37108446"/>
    <dbReference type="OrthoDB" id="4510945at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="452" mass="45224" checksum="6EA1C5820A7628B0" modified="2018-10-10" version="1">MTSPEHHASSLEAYIIPSPGCLQILLPLPLHAPSPSTICSLFQTTPTSTMFFTTSILAAALASYALAFPLDNAPNPTPVPALPPAPTIAPDQPPNPTAAAPGIGATVTITVSLPCFGATATLNPTLGLGARETEAAAGSASGSGSSISVLPSCVASQGPGSKPPSPTTTPCVSPSVIDPDNNNDNGNGDDNGDDDDTDADDVSVSSKLLLPPSSGVPTLPKPIQSKIVTTSTTSPTKVQTASISSSPSLPVTLTPSASTSPSPTPKVSFSSSAFDDDQDDDQTKTASASDSDIATATSTQTKDPAVPVLLPSSTFKTLASSEPAATTTTSTSTTSTTTPISSPTTKSKDLTITTPDSAVTTTTTSSSITSSTSSSTTSAPTTKSPITTPTPTKSLPTSTSTSTPTTKVPTSTATTTTAKSSPTPTTKSLTERKEDPNMPIKVPTVTPIPGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VL38</accession>
    <name>A0A317VL38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_578233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463599.1">
        <property type="nucleotide sequence ID" value="XM_025615205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VL38"/>
    <dbReference type="STRING" id="1450535.A0A317VL38"/>
    <dbReference type="GeneID" id="37117348"/>
    <dbReference type="OrthoDB" id="4358152at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY73847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="44208" checksum="2C0E610BB34CB744" modified="2018-10-10" version="1">MDYFSALPLELNVLILENVDDWVSLEHLIQTCPTVAALFEPGHDDPNTAANPMALDIVKCVLANDPIMSHKLDRLFWLCANLRHSPTYIKNDTIARFVSNDNEDRTESYECTMTRTELREMIRVAANIRRLACACLTSFVRCLQDNQPRCSSRDMRIETQPTRHHLLLLHADPPSWIEEYRVYRALWRLQLHTDLIGAGVWPPDDSGHLMDQFMSAWSCSKEVTAGREMRSVSECLVKLYGKSRTDIPCSKNQGSSELITCMPDTFVADVNLWVWSLPAQPNDLTQFWGPGPGRGGRCNIVHWFSQLRERFHISEFYLENDTVVDLALWAMGMWIWSDQRLREARLWRTEVDPAEGWVGVIGGWKTGVKNKSWSQRGSNPRPLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLV5</accession>
    <name>A0A317VLV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463604.1">
        <property type="nucleotide sequence ID" value="XM_025612582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLV5"/>
    <dbReference type="STRING" id="1450535.A0A317VLV5"/>
    <dbReference type="GeneID" id="37114725"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="68033" checksum="F848D5A61D130C77" modified="2018-10-10" version="1">MPELPPLAPVPPPEVQSTVLPAEWELYIDAWILLLGVRIEAPDSQFMQYASGDESAVAFLASFYLQSAKSGSSGVHAGPKARTLRKLCFLLTRRFLLEASPAPLELLEWNVLANMCCCYPSSSALKRLLSDAWNKHQDAITASLEKTKAKIIRELTLLHPSKSTAVLSDVRLLTILASALPGCGQVLMAGSDFLDTFSDAYQAHKREDFRSVLVANVYVGLASLLKGAKPNLSSLLDQLFSLKSSAGIGTSTTKKEPTLLSDVICSTDLLVRLDRYLSAHPQKRGQDLVSSLRTYQEESKLFHRRHQKQKRRVDKGKGRATDLPPAEDLHIHRMSLITQVQDLFPDLGSAYITPLTDPHSLHLGRANADLTADAVLADRTNHTANKAAIMSALAAFDSDEDERDDTYDIADVGGTIDATDDTDPRTSSTTTDPNETEMTLYRAYKYNPALFARDSTTRRSQPRASLKRETGMTDEAIEGWAVMLTRDPKRLSKLEDKMSLSAGGPDGTLNQQDLPPTAYRKPGPDDSQSDTEDQHPSSRGRGGGRGRGRGGRRGGGGGRGGGNPSAGSSGHQQNGNPAVARQRKEENKASRANHNRRQQRAKKVARAGACTGFTISHEKVGDSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTM7</accession>
    <name>A0A317VTM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_474450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463917.1">
        <property type="nucleotide sequence ID" value="XM_025608513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTM7"/>
    <dbReference type="STRING" id="1450535.A0A317VTM7"/>
    <dbReference type="GeneID" id="37110656"/>
    <dbReference type="OrthoDB" id="4227485at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022198">
        <property type="entry name" value="DUF3723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12520">
        <property type="entry name" value="DUF3723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY75290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="147" mass="17352" checksum="E9A925C1E38EEA9B" modified="2018-10-10" version="1" fragment="single">IQQALFTEEEVRLATEQHSKYLKTTKVNIYQIHFNPPLPRELNPKNIDQFYKIFHKNQYHHLNIDNHILVIISQQDLTNTLQKTNILLLTNNPQPCPQLGLGIGQLQALHGRHHVQARANVLPPTNHWWTVNLYKNSMYYTFYFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUJ6</accession>
    <name>A0A317VUJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Family A G protein-coupled receptor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_588368</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464576.1">
        <property type="nucleotide sequence ID" value="XM_025615882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUJ6"/>
    <dbReference type="STRING" id="1450535.A0A317VUJ6"/>
    <dbReference type="GeneID" id="37118025"/>
    <dbReference type="OrthoDB" id="10261467at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY78064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="305" mass="33507" checksum="CF228551CAF25EB5" modified="2018-10-10" version="1">MIESFVRETQSFPWPEPTPTSSVAPIPTVVPGSDPIFQMLHDTGKRTLWVVTVLMGLSSLVFYVLGARVPLSKRVFHVLVSLASTISFIVYLALATGEGMDWKLDVVKEHNKHVPNTTQDYYRQILWLRYILWFLTEPLGLISLSLLSGLPGAHLLIAIAADYVMLGSGILGTYAGHTSRRWVWFTISAIGYLTTVYHISVHGSRAASNKDVQTKRFFGTLSGVMLFVKVLYPVALAAGALALKINVDVETILFAIYDIFSQGILGYWLILAHDGAPGITLNVDGFWSHGLGNEGAIRISEEDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUN9</accession>
    <name>A0A317VUN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_185855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464598.1">
        <property type="nucleotide sequence ID" value="XM_025606009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUN9"/>
    <dbReference type="STRING" id="1450535.A0A317VUN9"/>
    <dbReference type="GeneID" id="37108152"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="655" mass="72125" checksum="05914E03CD6B1775" modified="2018-10-10" version="1">MSSTKAVTAGRKKDAIHFVNARPASETERIKIQRLVRAHVGKWISDQTKDRSSGADSPESSQSPSTPDPSSRSPPQPPAPPGIGHHLLTPPNCSPSPAALTPPAFPLTAPSRNSPETSARHSSSISPPPHDYGLSDRLPAAEGWAGEPHLHFDPDEMELSPATSWQLQQQNLEGSPCDQSEATTRTTSPESLSPPDRSSATPPEIIETFGCAAVDPFHMNPMDMARTEVAATEEYCLYVLWPGLTPVSPGQEARPASCNWLPLALEDRTLFTAFVFGSLSHKRLRWVNGWISRDSFQPEEQRILQYCEMETIKNVTREVSNPNRAVCDAVILSVVCMAHNVAEDHGRGVHLTPPFDAPLPRLQWLDIYGALPPNLVHIKGLVQMVRLRGGIQNLTLPGLAATLSFSDIVTCSTFLMPPVFPFMPLHRERLGLSLQKMLGFAPVDIERRYAPLRDIGLTSDLVEVIYAMYIYTKIVEEHLKAHLVNPDYSLISDQRNLTHYTLLSLPAASQLDGFAAYQPHEIIYEACRIAALIFGVGVVFPLPAQSTPLAQLAKLIQNVLQISDLASTWNHPQARIALFWVLMLGGIAADDQPERSWFVHVLSQAAASHGIGSWSDARKLLGLMLWYDRACDRAGSDLWAEVKQSLIKMEELSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVR6</accession>
    <name>A0A317VVR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretion related GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_497541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464702.1">
        <property type="nucleotide sequence ID" value="XM_025609323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVR6"/>
    <dbReference type="STRING" id="1450535.A0A317VVR6"/>
    <dbReference type="GeneID" id="37111466"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="282" mass="30446" checksum="9EFA4A08AD03E226" modified="2018-10-10" version="1">MSQPWDYIAKLVCIGDSGTGKSSLTIRLCEGRFSSSHDVTIGVEFGSRIVPVGPPASRGLGGEFDSSTRNRTPSVPSSSSLPATATSSEPVASGLPSPPRRAQEVQKRMKLSLWDTAGQETYKSITRSYFRGASGALLVFDITRPSTFISCTQWLQDLRQIAEDGIVVILVGNKSDLAGDERSHQRRVTRQEAEEWCRLNNITRYVETSAKSGENVERAFLEVAEMIYRNIEAGRYDLCDRRSGVKGYGATGGSNPGIPKTVTLGLDDAMRKGGNGLAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWF9</accession>
    <name>A0A317VWF9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_588417</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464627.1">
        <property type="nucleotide sequence ID" value="XM_025615885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWF9"/>
    <dbReference type="STRING" id="1450535.A0A317VWF9"/>
    <dbReference type="GeneID" id="37118028"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01401">
        <property type="entry name" value="PncB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000014">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.140.10:FF:000015">
        <property type="entry name" value="Nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="182"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="342"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY78115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="489" mass="54786" checksum="B329431B48A1DE98" modified="2018-10-10" version="1">MAQTDAAPLPEGIFSLLDTDLYKLTMQCAVLKYFPDVYVTYGFTNRTPHMKLTRGAYKWLLAQMDALANIRITNEEIDFLKQRCPYFNHAYLNYLTSFKLNPSEQIEIHFTPEQDTGSDDDMGSVDYVIKGLWVETILYEIPLLALTSQAYFMFSDKDWDYSNQEDKAFRKGCALLEHGCIFSEFGSRRRRDYHTHDLVMKGLYQAAEEGKKQGWKGQFTGSSNVHFAMKYGVAPVGTVAHEWYMTIAAITDDYENANEIALRYWLGCFGEGVLGIALTDTFGTPAFLDAFRKPIPAFTSAGVGAVATTASGPSTMTSSTVQSEAETKPPIAAPLHDAQGEHSTKTYAQVYAGVRQDSGDPTYFVKMVRDFYDREGVKDPKTIVFSDSLDIEHCLEYKVIAEEAGFNPVFGVGTFFTNDFTNKSNGEKSKPLNIVIKIATANGRPAVKLSDNMGKNTGDKETVQSVKKKLGYVENQWEEGDESNRWARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXR6</accession>
    <name>A0A317VXR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative cell polarity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_183225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464894.1">
        <property type="nucleotide sequence ID" value="XM_025605990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXR6"/>
    <dbReference type="STRING" id="1450535.A0A317VXR6"/>
    <dbReference type="GeneID" id="37108133"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="129"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="736"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="358"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="163"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY78585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="919" mass="102104" checksum="A6B56748DC1B30B4" modified="2018-10-10" version="1">MNAHSGTMSPVSVDGSDWSGINQYQKSDPPFSPTFSTRSNLATPPTSGVPSGSSGAGLPTGAAGPVSDSGNPSPPSSVAARSSDGTLGDQRSKRQKRIEEVLGQHYVALRRFLHASYRDDKGNNKSNKARDKLLRLSSTQFHELSTDVYDELLRRQQAMPSSNRPPRPDVPPFLPPRKDFHEKRNQARQKLASLQHQRFRDLATDVYTELERRFPHFPSRESRRLSPAPSYRGRPSNGYPPNGYPPTPGGPRSQSRGPPSRMGYHPSGGSPASPMYPPRQGSLGGPPPGMNGDGGPMAKSFHSNTIVPNKSTMVEDDDDAAGTEDDYDARSDAFALDAVLQSRRGTGATLADADRKALAETQSQVSVLQDKVNKLEDLLKSKDEEISKYQEDQNKVEALEELVKSKEEELLKYQEDQDKSEVSSAERQEWEALKSDLESKISQAEDLNSSLQHELDKVRADHEAVEMDLRNQLGEVSRQSTGDPELEARFAELEIKHQALQTELQEQQQVTEEVRHEAAGFLREMRALSEQSQSRWEHEEQLTTEVHKLEDQVKQWKTRYEKAKAQLQHLRTSSIGTAEIRPDTFSISKDREFFHEDGLVKDVHVAKFQVAIDELLHIARNDDYHIVTRQINAVVIAVRHVLHDVQECQDPSDGLSALRTKAISKLSATANNLITAAKNFVSSNGLSPVSLLDAAASHLSTAVIELIRLVKIRSTPAEDPHDDDDDAQFTQMKSPDYFSVAPSQSRHSRNDSVYSAMSPPPDAPNGVPAAMQSYPSQSETHELQEMKLYVEDQTNGLVQSIQALIDSIRADRGLTTINTHVSAICSVVTNVTSSTQHFVKRPESNPALRQRIDPIIEMLEYHKHRLMGAAAEGDTSNSPEQLRDVTNKLPPIAFEIPRVTKELAHQLNPANFEEDDDFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYI7</accession>
    <name>A0A317VYI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_603770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464539.1">
        <property type="nucleotide sequence ID" value="XM_025616447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYI7"/>
    <dbReference type="STRING" id="1450535.A0A317VYI7"/>
    <dbReference type="GeneID" id="37118590"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF13">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="476" mass="51707" checksum="321BA63BD2719332" modified="2018-10-10" version="1">MSLTSCSPAAIQTPSLFGTVILTLSASWVTNYILNVPAEFNYNHGDIDVRNTQFCNITITYTHPAYNDQITVETWLPPRTQWNGRLQATGGGGWQAGRFVLSEFFMTGAIGEGYAVTTTDAGLGDGEGPSSWALQSPGNIDYVAFNKLGSRSLNDQAIIGKSLVRSFYGRAPDYSYWSGCSQGGRQGLILAQRYPTAYDGIAASAPAQSWTKFVSALYYRLLMRQWHGVSPLACELNFLTAEAIAACDAKDGIADGLISNVSACDYSPYTSVNKTFVCNAPNKTMTLSGADISQFGLVPGVNSSQSDIWFNLFVAKNASFDTFQMSPEVYQEFFHLATQEYADTINAADPDLTAFRNAGGKLLTYHGMADPSIPTKGTGFYYQSVQDRFPDAQDFYRYFESPGLGHGSGGLGGQPTTIFDALRQWVENGTAPDTLPVEYAGREGGHGVMHRILCPYRAQAKYMGGDISSAESFRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZ29</accession>
    <name>A0A317VZ29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein PXR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PinX1-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein pxr1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_538000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in rRNA-processing at A0, A1 and A2 sites and negatively regulates telomerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464337.1">
        <property type="nucleotide sequence ID" value="XM_025612393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZ29"/>
    <dbReference type="STRING" id="1450535.A0A317VZ29"/>
    <dbReference type="GeneID" id="37114536"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF31">
        <property type="entry name" value="PROTEIN PXR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="11">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="207"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY77150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="297" mass="32851" checksum="F71061936F1D1C7D" modified="2018-10-10" version="1">MGLAAPRKKIKISHDPNNTNWSRSTSGFGHKILSSQGWTPGSFLGARNAAHAEMFTAASATHIKVVLKDDTLGLGARPKRDPLDEPTGLDAFKGLLGRLNGKSDADLQIEQQKRDNAKLARYAASKWQTVTFISGGLLAQEKIEALATEDLQSNPKDEQEIKTSVSVFGDGKGQMSTDGSPTDGSQDYDKERDQPDGNIKRKKSKSKSKDRQEKKDKKRKQVEVPEPVRSEDKNTRSSERADTPSTNGHKEPLPAAKVLSKERRPMGRHVFRGRHIAQKKKALLDEKSLNEIFMVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZV5</accession>
    <name>A0A317VZV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_178287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464777.1">
        <property type="nucleotide sequence ID" value="XM_025605957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZV5"/>
    <dbReference type="GeneID" id="37108100"/>
    <dbReference type="OrthoDB" id="10467520at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="110" mass="12295" checksum="6AF8242AF24931A4" modified="2018-10-10" version="1">MVQGTGRNWVFAYTVRSSVLHIPIGRKWGEPPPAPRFLHITYFWTLLRTFPPSANAMVGHAVIIMTCLQWRAFLGEGNTTKYCQGNKGRAAPLSVSWTDHLFRFSGGGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W0U0</accession>
    <name>A0A317W0U0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Synaptic vesicle transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_626408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465081.1">
        <property type="nucleotide sequence ID" value="XM_025617355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W0U0"/>
    <dbReference type="STRING" id="1450535.A0A317W0U0"/>
    <dbReference type="GeneID" id="37119498"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF152">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY79509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="494" mass="53018" checksum="BCF4891FEBF74631" modified="2018-10-10" version="1">MKGPMPAMAPDLESQPAPEAATAPASEKTLPTSEKTSGKSSAITNGYDLPFWRKSIILFIVSWMTLAVTFNSTSLLPATPEIATQFDTTEEILNVTNAGVLLAMGFSSLIWGPMGQLIGRRMAYNIAILVLCGCSAGTAAATNMQMFTAFRILGGLTGTSFMVMGQTILADIFEPVVRGTAVGFFMTGTVTGPAIGPCIGGIIVTWASWRNIFWVQVAMTGFGLILSFLFVPEIPSADTKITSTATEKPYSRTTKTLHIISAFNPTRIFRLWVYPNIFLADLTCGLLSTFQYGLLTSARSIFNPRFHLTTALVSGLFFLSPGAGFLVGSILGGRLSDRMVKKWIVKRNGVRLPQDRLNSGLITLFLVLPAAALIYGWTLQEGVGGMVVPIIAAFFGGVGLMGTFNGLNTYAAEALPHRRSEVISGKYIIQYLFSAGSSAAVDPLIGAIGVGWTFTICVFFSLIGGVLVVIITRKGLDMQRWVERKFGLVGKGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1K3</accession>
    <name>A0A317W1K3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_548850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464562.1">
        <property type="nucleotide sequence ID" value="XM_025613421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1K3"/>
    <dbReference type="GeneID" id="37115564"/>
    <dbReference type="OrthoDB" id="4506340at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="192" mass="22807" checksum="527846FD0A975963" modified="2018-10-10" version="1">MSSTDEPAPNVQELQSLINGRLQAQGYEERIVTDEIRTYWVGPRNEIVKLQRILAVIPTDEEKSTLRKILSAWMNDQRENKPQYDPFRGFLQDGYRVQFFVERRREEGAPVEADCLEDLRLDPNNPAKLEYDTRDKDDKKIIERWLKQEARRNPPSNADRTFTDNAKYNEIFDIHFLRYFDLQIRNGLVWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1R0</accession>
    <name>A0A317W1R0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cora-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_626205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465272.1">
        <property type="nucleotide sequence ID" value="XM_025617344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1R0"/>
    <dbReference type="STRING" id="1450535.A0A317W1R0"/>
    <dbReference type="GeneID" id="37119487"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY80413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55580" checksum="E9DB1B4376238116" modified="2018-10-10" version="1">MSSYRSYVAKQSRRYPSSLQPLCYFLDDPLVDQNVCRMGVLEFTPDTPAPAYRDLDHQGLYSILSDDTTTKSSFPYGRIVIIEDLSREIVEMLGSLLHIDPLFFASHIGHNGPSGDSTIASALRSRKQPFITNHYYRAVTLHGLQEGCSSQYSRETNVNREVMLLPPTQDGTCNALIQHNCSIFVQQNRNDGWLGLILVDPSIHNNHLILRQTSNSKHLPYTPTCHLFQGGYEDFLDSNSPANEWDSYYPPRHGLFEDQIYYWQTECPTSFKLANPPTISLAYYPIQIILSEWTNTLTALDQHIQHHETTISSLPNQPLHPDQSNPNPNLHALMTLHRRLQTFTTHISQTHHFLQHQEKTLFDLLHSYETIATALAQLSSTLSNTLIPTAASLTQLVEIKRTESQTFRVNQLTYLAFGFVPLSFVTSLYGMSDEFAPGGKNFWQWFVVAIPLSVFCLWCMESSTRPDGWLRRMQGRRLRIELLGGVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2Q1</accession>
    <name>A0A317W2Q1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1295-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_536976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465355.1">
        <property type="nucleotide sequence ID" value="XM_025612164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2Q1"/>
    <dbReference type="GeneID" id="37114307"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="347" mass="39139" checksum="4D940ECAD13D271C" modified="2018-10-10" version="1">MNLSSSSPYGDIAHPHPRHFHHPHPHAPLHTTDIGLFKSTLLPSFTLHTTLDLAAFIASKATDRAEIKDWCWPSSQVLNAWWSAIGHQVLYHNISPQTAWSSLSWTEKVLLSAVTLWGTRLFTRVASRTITRGKDDPRYDQLKKEDPQGFWTSALLKQYLPEAAFLTLISLPFTVPFRLTSSTLALDSDVLATVRAFGVALFGAGFALEVLADAQLEKHREERTDLCRTGVWSIVRHPNYLGDTLVHISFAVLNMANNFNPIVLLGPLTNYIFLRFVGGDKQNEASQETRYRAEDPHKYEQLQAWRREKNSFWPGFTEVVNPWTWAVVGAGVVGVVVEEGIRGWISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4L8</accession>
    <name>A0A317W4L8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_144889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465592.1">
        <property type="nucleotide sequence ID" value="XM_025605753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4L8"/>
    <dbReference type="STRING" id="1450535.A0A317W4L8"/>
    <dbReference type="GeneID" id="37107896"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="388" mass="43852" checksum="9F2FE8E31AD55353" modified="2018-10-10" version="1">MPPRPVDAPISQFTGLGIMLPRQKSGPPQYLALRALWKCNKRTLFQPSDWRIQGVAKARKSLKGLAHWEKFLHAVPLVFSEADILPVTSDLGDLKLIWYYGQLIRSAPAQDRPDNEDNVRFTPISKRTKFQEKQVAKQGSVLDTPTPLPKEIAITNLLGHFSLDENPTSDPKETPSTDFYPDSPEDDLRRDPTYEDGSDDFPPVSDENLVNTYLLGLASLVTMSSEGVQAHWSQQRKAYKVRSKGAKLYEARTDGHLFLTEGKQTKAIVEVKAMARDDLPTVRMQETAEIAAWIHECPDEILKDTPKDKVFRRLLFSENRHEIYLIIAEYSANYVDQLTNPNHASKSKSFLTMNEYGPWDIGVRDDVEDIASVMLAVTLQFSKGLPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5B5</accession>
    <name>A0A317W5B5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_547816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465601.1">
        <property type="nucleotide sequence ID" value="XM_025613357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5B5"/>
    <dbReference type="GeneID" id="37115500"/>
    <dbReference type="OrthoDB" id="4508807at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY81533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="178" mass="20562" checksum="865B8FE154DC9E1E" modified="2018-10-10" version="1">MELVFDDVNIRDYRDVHLKDALAHVLNIGRTLAQCSKMGSVLMDSWAQTQLVRLDVLFRCLDTTQFHFWVEDGFQADVSHVEHLLECIAEFAQDCLDAGRLGSHPCTRHLGTDGGVARTEAQGEREQIVNEWDWEFEGEDVSLVQRKVPRLETQMVKLEQAIIALALKVHCMRTRWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5H9</accession>
    <name>A0A317W5H9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_587756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465157.1">
        <property type="nucleotide sequence ID" value="XM_025615849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5H9"/>
    <dbReference type="GeneID" id="37117992"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="251" mass="27977" checksum="152A8A56F5631A04" modified="2018-10-10" version="1">MSACTISPKQILKRELSQREYELLQEWAPETLKDYTLPKPNPPMNRLPQYQTVPSQLQGPSPRRSKVRSSSVYEEWKSQASHGRTVNETPTMAVSKENQSDATVSPTNARVNSNQPGSPSSPASPASPATSAGAKLCPQEPVKIVTSNNHYAKPTVSTSNRSMTSPVSKMASKAGEHSNKTKGLENRQRPRQDIIVYTAPNGCKVRRDVLSKWSLGIKTSNKLTIYFRPNFVEDPWKGLKPVLTISHKHWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W758</accession>
    <name>A0A317W758_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_602226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465450.1">
        <property type="nucleotide sequence ID" value="XM_025616415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W758"/>
    <dbReference type="STRING" id="1450535.A0A317W758"/>
    <dbReference type="GeneID" id="37118558"/>
    <dbReference type="OrthoDB" id="5396831at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="338" mass="38685" checksum="6E800EE78AEDED75" modified="2018-10-10" version="1">MLTPLYPPQDLWPGGIPTQIHLDNGPGLDYEEMAEASKGWCLFVQVSTPNCPCSSRNIQFWLRIVQSYYSRAPLPPSALHYPPSLLHRSRSRPKNFICFAPVNRDKDHAKNYTHLTKLLILLYIHENWAPSHPFSYDPSAPHPSIPAQYPDLARYPSSENFISLYYLETADFRYLSVTRTGTVFLAAIGQIYTVIDQDTLKTGRLALFSFQSNGQVKSSTRLRPWHMGAEMSTHHMLGWPLERLIDEHSYYHLGCDPLNMDLPIVDIVNSSTQRGELHVPYSREHWALELELFAPGYLELEARGLEVEYELTSLSDEMDSYNHRVPPQKGPYRPGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W7C2</accession>
    <name>A0A317W7C2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_152281</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465510.1">
        <property type="nucleotide sequence ID" value="XM_025605808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W7C2"/>
    <dbReference type="STRING" id="1450535.A0A317W7C2"/>
    <dbReference type="GeneID" id="37107951"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="12">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY80908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="581" mass="63766" checksum="7C1B9BECE363230D" modified="2018-10-10" version="1">MCGIIALIQANPSSSAAIDLHEALYLLQHRGQDAAGIATCATGGRIYQLKSNGMAAKVFNDGARVADLPGSMGIGHLRYPTAGSSANAEAQPFYVNSPYGICLAHNGNLINAPELKRYLDLEAHRHINTDSDSELMLNIWADELSETKKARVNTEDLFASLSRMYERCQGGWACAAMLAGFGLLGFRDSYGIRPLVLGSRASLDGEGTDYMMASESVALHQLGFSNIRDIQPGEAVIIEKGCEPVFRQVAPKMAYAPDIFEYVYFARPDSVIDGISVYRSRQRMGDRLAARVLDVLGPEVVKDIDVVIPIPETSTTSAAAVARYLDKPYCQGFVKNRYVFRTFIMPEQKTRQKGVRRKLNAMQAEFKDRNVLLVDDSIVRGTTSREIVTMAREAGAKKVYFASCSPEITHAHIYGIDLASPTELVAHNRSVEDIAKHIGADSVIYQTLDDLKGACAEIAQENGLSEPRDFEIGVFCGNYVTPVAEGYFDHLEKLRGEGRKIKALDRAKEAVTHGFASEKDFRMAANGVKLDDKGNIIPAQDPSESEVPQVSVCTTRKHTEEEPPKVKDRMDISIHNIADHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WAA0</accession>
    <name>A0A317WAA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leo1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_587195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466088.1">
        <property type="nucleotide sequence ID" value="XM_025615807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WAA0"/>
    <dbReference type="STRING" id="1450535.A0A317WAA0"/>
    <dbReference type="GeneID" id="37117950"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146">
        <property type="entry name" value="LEO1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23146:SF0">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN LEO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="56390" checksum="04B111B95CFD93F6" modified="2018-10-10" version="1">MATDSGASFFVRPGMQQHWSTGAEMQELRASSNDLHRLNCAHPVRAPSPSNPMSSSDEDIVRRPGRGTGAAQPGSPSASEHSEVPARSQSPIGSDAGNVNGYDDADLFGSDASDGGFGDDNDRPQRRLDDEELDSGDDVDRNDRVGEPMDYEGGADYEETVNIMDLGLSRAPEPVTSNGEVYTIPVPHFLSIETEEFNPETYVAPPFATAATSLCWRHDPEDESLLQSNARIIRWEDGSMTLQLASAPKEQYRISTKPLAPLSKSGEYDTKLDSHVYLGAAAEASSVFRLTSHLTHGLTVYPTTMETDDAVQRLQESLAAATRGAKKTLDGSAPVIEVKEDPELAKRQAEMAEREKLKAARRRQQLQDRELDRGRRHGFPHRTGGAGLTVGGLEDDDGLLTTRAKKPRKPNRRGEIYTDDEEEYDRRGRTREDEYDEDDGFLVGSDEEPEIVDDDDEEDVLEDDDMDAEGDEEDIPPARPRQKRASPEAERGTPPTRKKNRYIVDDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBT2</accession>
    <name>A0A317WBT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_115500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466281.1">
        <property type="nucleotide sequence ID" value="XM_025605533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBT2"/>
    <dbReference type="GeneID" id="37107676"/>
    <dbReference type="OrthoDB" id="5425637at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016359933" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY83813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19054" checksum="52339D4FC4AA223B" modified="2018-10-10" version="1">MYSTYLFLLTVVTLSSPAVAQGILSSVDSQDGSGESESSLTHSVSSKGMIILCTIVAVVVLIGGMFWRGDTSKYMNKLNNPALTTPPSLVVFTAVFITAKKRRLKTREAVSFTDSTDGPLSVTHTTGRGQPISESTKGGAIQPDLEKNARVRQDRSHRDSDTKQRGWGSYFSFGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD19</accession>
    <name>A0A317WD19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_536346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466119.1">
        <property type="nucleotide sequence ID" value="XM_025611997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD19"/>
    <dbReference type="STRING" id="1450535.A0A317WD19"/>
    <dbReference type="GeneID" id="37114140"/>
    <dbReference type="OrthoDB" id="7862313at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="10">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="386"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="8">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="651"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY83651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1094" mass="121565" checksum="094996267564DFE2" modified="2018-10-10" version="1">MDQQRFLQQLQIVLNPAQGNVKEATGVLQREFYKSPESLVLLIQIATGHEDPNLRQLAAVESRTLVVKHWVSVQAGQKPQIRQELLRAAVGESSSLVRHSVARVISAIAKIDLNDGEWADLPNFLLRAASTGNKEERAVSIYILLTILETLGDGFEEKFDELFQLFSKTISDPESEEVRMNTLMALSKLAMYLDSEENMAPVKAFQNLIPSMVAVLKDVITREQDDGIMQGFEVFQTLLGCDPALLTVHLKDLVIFMNELGGNVEQEEDVRTQAISFLMQCVQYRKLKIQGMRIGEQLTRTALQVVTELDDASPTDDDITPARSALGLLDILAQSLPPSQVVVPLLQALGQYFNNSNPDYRRAGILALGMCVEGAPDFISTQMHEIFPMVLQLLADSEPKVRQASLHAVARLADDLAEDLSQEHKRLMPLLFQNLASAMQEYKGEEDGPTVDIMKAGISAIDAVVDGLDEKDVAPYQGELVPILHNLFKHPDFRIKGLAAGALGSLASSAGDSFLPFFDESMHLLQEYATVKDSEEELDLRASVTDAMGEMAAAAGPERYQPYVEPLMRATEEALHLGHSRLKESTYIFWGAMSKVYVELFAPFLDGVVKGLFACIEQDETDLDVSLGEAAKDLIGQEVTIGGKKVRVADADEDDEPVGEDGDIEDVDLDDEDGWDDITATTPLSLEKEIAVEVIGDLVTHTKSAYLPFFEKTIEMVLPLAEHPYEGVRKSTISTLHRSYAMLYSIAEESGQMGKWQPGLPLQVQPAKEVQKFGEILMTATVKMWTEEDDRATVADINRNMAENLRYCGPSLISNETTLHNVIQMITDIITKKHPCQLEFGPEEETAEAGEETSEFDWVVVDTGLDVVSGMAAALGPSFAELWKVFEKTVLRYAGSTEALERATAVGVLAECINGMGPAVTQYTPTFMKLLLHRLGDEDSQTRSNAAYAIGRLVEHSDAKDLIVKEFPTILSRLEQCLHMNVSRLQDNATGCLSRMILRHRENVPIKDVLPVLLTILPLKNDFEENDPLYHMICQLYKWEDPTVRELTPQLLPIFQAVLSDEDQLEEERRAELIDLVKWLNQMQPGAAPWAEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD63</accession>
    <name>A0A317WD63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_547355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466159.1">
        <property type="nucleotide sequence ID" value="XM_025613329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD63"/>
    <dbReference type="STRING" id="1450535.A0A317WD63"/>
    <dbReference type="GeneID" id="37115472"/>
    <dbReference type="OrthoDB" id="4369561at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="284" mass="30793" checksum="F9D464B6682F2772" modified="2018-10-10" version="1">MRNLCTVDMRVILDQIEFYHGPSLQRPSTSAKKVSTGHATAHAPRTFHRYSPTGSGFCQRPCEASLGQAPPLTGTTHEWNMFDIAIDNVYGSTWPQITKGIEPAATTNMPTARDMLLDGRSSTLADSVSLRHSTRVTCPAGADYLDRIPPDMRENDLAEMETSRLSCVPCVTAPVPAPEQANTAFSNIFAVGDSQQRSVKRKLSITGSSHSDSMHHWGDEKDTEPSQTAELGGIPCYRENDAPKRAKDSNTAENKSASSGPPTVRSTPEYSGARMALSSDKPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDF0</accession>
    <name>A0A317WDF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_117633</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465853.1">
        <property type="nucleotide sequence ID" value="XM_025605548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDF0"/>
    <dbReference type="STRING" id="1450535.A0A317WDF0"/>
    <dbReference type="GeneID" id="37107691"/>
    <dbReference type="OrthoDB" id="1928777at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12121">
        <property type="entry name" value="MARK_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14077">
        <property type="entry name" value="STKc_Kin1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000333">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001772">
        <property type="entry name" value="KA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02149">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50032">
        <property type="entry name" value="KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="191"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="KA1" evidence="16">
        <location>
            <begin position="1026"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="584"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="959"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="798"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="818"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="833"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY83068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119476" checksum="855C1D06E8C97AB1" modified="2018-10-10" version="1">MSTAAPPTASPSVVRSQSTSSRPSSYRPPSSDLPHRTRSVAVRPATASQPSPQHHHHHHHHSQNRYSHSYSKSQSYDRRPPSNQAVFDNIARRDYEASRGAQPVPSRRDSSRERSQERPSTSYRTEQPSNKHHRNLSVQGHQRDSIDMATAGPVIAEGVAGHSQAAAPHLHPANSVQAKRRTMITTPSGQWALGKTLGAGSMGKVKVGKNMETGEQVAVKIVPRQSTEEHRSSREAERADRSKEIRTAREAAIVSLVNHPYICGMRDVVRTNYHWYMLFELVNGGQMLDYIISHGKLKEKQARKFARQIASALDYCHRNSIVHRDLKIENILISKTGDIKIIDFGLSNLFSPRSLLKTFCGSLYFAAPELLQARQYTGPEVDVWSFGIVLYVLVCGKVPFDDQSMPKLHAKIKQGVFEYPPGLTTECRHIISRMLVTDPKQRASLSEIMNHPWMNKGFNGSPDNYLPYREPIQLPLDPEVIEKMTGFDFGPPDYISAQLTKIVESEDYQHAVKAMAREQLPPSHTEKKRGVFDFYKRRNSASRDTLSTPSAEAVQLGNDPVNAYSPLLSVYYLVKEKLDRERVETNPGALGVPHATGDSMLQMPDLPAPEAAHTNQYHVPGEKDTGRRSRPRARTHGDDDIADGIKNLHLGPQTGHSPAPPASQPETPVKKESTAAGILRRFSTRRTKERSRDPERGRIGSPHTPSLNVQPPADSASPLSRGFSVKRTRRADPSPTAVHSGSSQPQHQDLLKAPGSTEPASRSNKFLERSASVNSADYRARRARRQEAEAAAQPPPTSGSDYANVQKDSTPGKEAKLTRTQTHTARTMSLGHARRESIQARRARRDATREANVPEETDADITGAGTALESANEGEDLSKPVYLKGLFSVSTTSSKPLPVIRADIIRVLKQLSVDYVEIKGGFSCRHAPSIDLDKVVDVGPPSPDRQGHMSGHRRRISFGGFLNHEDRDDSRHHTPRPQRRTRAAPDQSFVTNSEGSDEDDGSRDHRDNLMVGERVMGETTTRVQSDTGENLVLRFEILIVKVPLFSLHGIQFKKVAGGMWQYREMAKKILDALRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDH1</accession>
    <name>A0A317WDH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_536742</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466057.1">
        <property type="nucleotide sequence ID" value="XM_025612095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDH1"/>
    <dbReference type="STRING" id="1450535.A0A317WDH1"/>
    <dbReference type="GeneID" id="37114238"/>
    <dbReference type="OrthoDB" id="7403325at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004760">
        <property type="term" value="F:L-serine-pyruvate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019265">
        <property type="term" value="P:glycine biosynthetic process, by transamination of glyoxylate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000049">
        <property type="entry name" value="Alanine-glyoxylate aminotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000027">
        <property type="entry name" value="Serine--pyruvate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152:SF24">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21152">
        <property type="entry name" value="AMINOTRANSFERASE CLASS V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="11">
        <location>
            <begin position="27"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY83272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="386" mass="41728" checksum="B3A7E223F8411BE9" modified="2018-10-10" version="1">MSSQAPHPTLLIPGPIEFDDAVLQSMAHYAESHVAPGFVKTFGETLSLVRKLFQSTNPAAQPFVISGSGTLGWDIVASNLIEKGENALVLHTGYFADSFATCLETYGANATQLKAPIGERPSFEEIEQALKEKPYKLITITHVDTSTGVLSDIKRVAEIVRRVSPETLVVVDGVCSVGCEEVAFDEWDLDVVLTASQKAIGCPPGLSILMLSGRAIDTFKSRKTPPSSYYSSIANWLPIMQNYENFKPSYFATPPTQLVHALHTTLSQITARPMAERFAVHAHASERVKAAVAELGLEQVASKRENQAHAMTAIWLPEGLAPPDVLPGLLKRGVIFAAGLHKQVATKYIRFGHMGVSVTDPNRSDIDKAIAALKEAVSEAKQAKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEY4</accession>
    <name>A0A317WEY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_625107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466500.1">
        <property type="nucleotide sequence ID" value="XM_025617256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEY4"/>
    <dbReference type="STRING" id="1450535.A0A317WEY4"/>
    <dbReference type="GeneID" id="37119399"/>
    <dbReference type="OrthoDB" id="5345625at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="406" mass="45070" checksum="E23B673992DD4110" modified="2018-10-10" version="1">MSSIMAASHPSPVKDGRRILGEKPANACLSPAHHRHASVSPLKRPFLEAPSSPKKLLRSPLFAGQKRSIDQVDTNEPPSSTQPSAQAPSRPDASQNVQDDNLPQQDSQIQQQSHATESETTLLDSDKQQHHHHHEPQPTQQQPQPQQEDTHFVSPPPATTTTHPIPNDPETRKRFIKEKATLLRTRLQTAMRNIHDPQLDRRLSDLEAHSRKYPRLSLPQEQRSTIQSTPTQSSSSSNPCLTTPRVHTAPQLPPSSALHASGLSSPPLSAGTTTTPAAPHVEDQDLEGDEKEEGEEENDPMKTPTQKSHRRMDMYTQTQTSPMQLSSPPATVSRRRITTAITEEFLRADDEQEDVMREVGEAGEDMEQSHPEERQRRLSQKGDAVDGLLKLMNTGDQSEGLEVWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFF5</accession>
    <name>A0A317WFF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydroorotate dehydrogenase (quinone), mitochondrial</fullName>
            <ecNumber evidence="5">1.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_536267</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-dihydroorotate + a quinone = orotate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:30187"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.2" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466600.1">
        <property type="nucleotide sequence ID" value="XM_025611975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFF5"/>
    <dbReference type="STRING" id="1450535.A0A317WFF5"/>
    <dbReference type="GeneID" id="37114118"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00946"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106430">
        <property type="term" value="F:dihydroorotate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04738">
        <property type="entry name" value="DHOD_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000242">
        <property type="entry name" value="Dihydroorotate reductase PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005719">
        <property type="entry name" value="Dihydroorotate_DH_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF4">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="13">
        <location>
            <begin position="153"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="13">
        <location>
            <begin position="483"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY84675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="533" mass="57239" checksum="B8CC4025A04D4797" modified="2018-10-10" version="1">MATHAVALAWRSAGRRAPALPSLRATQRTSILHRESLLRQVRYSSDAASQTKEAAKETTAQVTETVKETPKKAGRKLKRTILGTSLALTLLVSYIYGTDTRASVHRYGVVPLVRLLYPDAEDAHHFGVDILKTLYKYGLNPRERGDPDGDGSLVTEVFGYTLSNPMGISGGLDKHAEIPDPLFEIGPAIVEVGGTTPLPQEGNPRPRVFRLPSQNAMINRYGLNSKGADHMAAILEQRVRDFAYANGFGEHDLAEQRVLNGEAGVPPGSLREGKLLAVQVAKNKATPDSDIEAIKRDYVYCVDRLAKYADILVVNVSSPNTPGLRDLQAAAPLTAILKAVVGAAKSVDRKTKPFVMVKVSPDEDSDEQVSGICDAVWGSGVDGVIVGNTTNRRPDPLPKGFTLPSKEQTALKETGGYSGPQLFDRTVSLVSRYRSLLDATAPTTSKVIEAQEASATATKAEPDMENLPPVEAPSASEVLPRKVIFASGGITNGQQAKAVLNAGASVAMMYTAITYGGMGTVTRVKDELRKEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH41</accession>
    <name>A0A317WH41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_557097</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FYV10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466690.1">
        <property type="nucleotide sequence ID" value="XM_025613915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH41"/>
    <dbReference type="STRING" id="1450535.A0A317WH41"/>
    <dbReference type="GeneID" id="37116058"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="12">
        <location>
            <begin position="164"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="13">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="329"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY85673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="406" mass="46600" checksum="639C6F61138F31D5" modified="2018-10-10" version="1">MAAELTSTRLNAENHLLLDQPLLRLPHELARRNFKSVQRLVEREREYVIPVLKETANASMSNNQTPERALAALDAMVSRMQGLKRKMEILHQEEKKIQEQSRKRIHHLERLHQIPSLADVKYDHWARVRLDRLIVDHMLRSGYTESAQQLAHEKDIEDLVDLNVFVQCQRIAESLRYGETKDALQWCGENKAALKKSQYNLEFELRLQQYIEMVRTEHKEKLVDAMVHAKKYLAPYIETQSMEIHRAAGLLAFPPDTKAEPYKSIYALERWTYLADLFVRTHHELLSLSSRPLLHIALSAGLSALKTPSCHSAYTSSSSNSLSTTTSVCPICSTELNELARNMPYAHHTKSYVESDPIVLPNGRIYGQQRLLEMSKKVGCVEAGKVKDPTTGEVFNESDMKKVYIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH46</accession>
    <name>A0A317WH46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_597897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466823.1">
        <property type="nucleotide sequence ID" value="XM_025616278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH46"/>
    <dbReference type="GeneID" id="37118421"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY85806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14308" checksum="7D4C1C8BEDFBF539" modified="2018-10-10" version="1">MGNISIKKYHQLDPIKNSLPNLLYVSSGIIAVILTPYHHLTPHPNPTRRTKHFHSQLDLHYHHPPPHQHHPPCPLPPATPNAPPGPPSLTTKPTSSSTTCSSTDSRPEAWSSTGAPTKVTPSGSHSCLAFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ69</accession>
    <name>A0A317WJ69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DUF1212-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_467054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467095.1">
        <property type="nucleotide sequence ID" value="XM_025608195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ69"/>
    <dbReference type="GeneID" id="37110338"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="608"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="644"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="712"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="767"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="835"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="420"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="693"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY86504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="870" mass="93892" checksum="A5A464C1AB16731A" modified="2018-10-10" version="1">MAGGYFDLPISSSSRRSSLTDLSGGPSRSSPGPRVLSPLPTPNENPQERSLEPSGAQGRLRNAAIPRSTNRVKFTVSEAGLGATTAGSTSETRFDGRGSSLPQRPLPTASSIPSTVKASPDPQSVPLIDISPSTPVGVTGLTIHPAARSTGSPGDDDEVSNEKGRAIHSAQERAQRLASLLHRSSKSPKTSPWSSRPSSIASTPSEVVLPSEDGDEIPMISLSEKHFDDLSDDDEVGPLNGRQSIRTSQAHQLVRQMTRNDFSFLTRIQVPSAGLRSGQVTPLEERDPDAYVERPAHYRGGILSSLLKLYDQPGSNYSRGRHGSLRRSSTGEFSSRGLSPDPTWKSQRPRKWYEKSPNQSSTSLAGSTAKNSASSPIAMLKRSRSSGAIPSVPKRMGKPQLEDEIRITIQIAELLSRQGYLIRLCRALMKYGAPTHRLEEYMKMTARVLEVDGQFLYIPGCMIISFDDASTHTTEVRLVRSHQGVDLGRLSDVHLIYKEVIHGVIGVEEAIQRLDEIVKQKNKYPVPVVILIYGCASACVGPFAFNARPIDMPVAFLLGCLLGILQLVLSPRSNLYANVFEISAAVLTSFLARAFGSIRYGDGRLFCFSALAQSSIALILPGYMVLCASLELQSRSIVAGSVRMVYAIIYSLFLGFGITIGTAVYGLLDSDASSDYTCPASPITNEYLQHFPFAILFTFCLAVINQAKWRQMPMMLMIAFAGYVTNYFGTKRFYSSTQVSNALGAFVIGVMGNLYSRLRHGFAAAAMLPAIFVLVPSGLAASGSLISGIAAAEQITTTPSPFSVVSNGTQGFVDAARNMSSPNFDREFHGVVLDIGYGMVQVAVGFTVGLFLAALVVYPLGKKRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLD8</accession>
    <name>A0A317WLD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_586106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467112.1">
        <property type="nucleotide sequence ID" value="XM_025615735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLD8"/>
    <dbReference type="GeneID" id="37117878"/>
    <dbReference type="OrthoDB" id="4157208at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="126" mass="13009" checksum="5D4B14F1C64F54C2" modified="2018-10-10" version="1">MDGSSRTLSPFDPPQPTTQVSPGYSVQPQNPLGLAAAAAAAAVNSQTAMQLQSQPATATATEQQHPTDLSQSAAAAVAQDTYPHQISESGGPTATAPFLRDFSLVAEAAKRAQMSVMVRDLESVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLE8</accession>
    <name>A0A317WLE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_624349</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467367.1">
        <property type="nucleotide sequence ID" value="XM_025617212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLE8"/>
    <dbReference type="STRING" id="1450535.A0A317WLE8"/>
    <dbReference type="GeneID" id="37119355"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="141"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY87159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="363" mass="41435" checksum="FC83017B5B86F489" modified="2018-10-10" version="1">MFRPPIVRAFSRVSPRPATTSSSSRIASRILTPVQAFRRFQCRPFSRSARKNGWESNKYKRPEDWTHISNLFNLKNLIYPVTAVLAFYFYNLETDEVTGRTRFIWIPRWMENQLVDNEYRRLLHGFAGNGLLPDNHPLTMEVQEILDRLVAHAPVHDADWKVHIVHDLTVQNAFVLPNGKVFVFSGMLIPLDDADGLAGVLGHEIGHVLARHLAEHLSSRPFIALAQSLFVNTFGRLGFFVSDAINTFDEVRNTRSVEAEADNIGLMLIAKACYNPRAAVNFWERCSKNVKNLPPPELLLSHPLPFERMQALSERLYRAEALYEDSGCHLLRGYISGFGDAADHYAHWDTDKYDPKLRGNGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNE9</accession>
    <name>A0A317WNE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4-aminobutyrate aminotransferase</fullName>
            <ecNumber evidence="3">2.6.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GABA aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-amino-N-butyrate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_535912</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23352"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="2.6.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.19" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466787.1">
        <property type="nucleotide sequence ID" value="XM_025611895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNE9"/>
    <dbReference type="STRING" id="1450535.A0A317WNE9"/>
    <dbReference type="GeneID" id="37114038"/>
    <dbReference type="OrthoDB" id="10260828at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034386">
        <property type="term" value="F:4-aminobutyrate:2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000029">
        <property type="entry name" value="4-aminobutyrate aminotransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004631">
        <property type="entry name" value="4NH2But_aminotransferase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00699">
        <property type="entry name" value="GABAtrns_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206:SF1">
        <property type="entry name" value="4-AMINOBUTYRATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43206">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY85770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="498" mass="55482" checksum="5D6A78E7BC9D487A" modified="2018-10-10" version="1">MAALFRSSLKLRPATRLSAVRTLTTTPHLRAAEKPFFPDEPTAPKLATAIPGPNNKAAAEKLDKVFDVRSLNMLTDYTKSTGNYIADLDGNVLLDVYAQIASIPVGYNNPHLRKVAESPEMITSLINRPALGNFPSHDWADILNTGILKAAPKGLNQVFTAMAGSDANETAYKAAFMYYRQRERGGPETEFTEEELETTMKNQSPGSPQLSIMSFKSAFHGRLFGSLSTTRSKPIHKLDIPAFDWPQAPFPALKYPLEEHAQENAQEEQRCLQETERLIKEWHNPVAAVIVEPIQSEGGDNHASPAFFRGLREITKRNDVLFIVDEVQTGVGATGKFWAHDHWNLETPPDMVTFSKKAQTAGYYYGNPALRPNKPYRQFNTWMGDPARALIFRGIIEEVERLNLVENTAATGDYLFAGLERLAKQYPEHLQNLRGKGQGTFIAWDTPKRDEFVAKAKGVGVNIGGSGVSAVRLRPMLVFQKHHADILLESVEKIIKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQX6</accession>
    <name>A0A317WQX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_52697</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468178.1">
        <property type="nucleotide sequence ID" value="XM_025610370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQX6"/>
    <dbReference type="STRING" id="1450535.A0A317WQX6"/>
    <dbReference type="GeneID" id="37112513"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="589" mass="67791" checksum="56723D540A6DA2B6" modified="2018-10-10" version="1">MQPRQYRRRHACARCIQLKVKCVPVRDTRSCERCTRLSHACIFPESPRPSSNRKSRIDVLQEQVDKLVAELEATKQDSDKHAPCQPSKNQTYIVANHQYLEGTPGKKSSFGADTDQDFISRGLFTLLECEELLAKFRTHKMPQFPFVIVPTQLGVPTLRQEFPFLLLCIITASLEHKPSLQHHMEHEVRKVIATRLIINMERNMDLLLGLLIHIAWYHYHWRTYHTQVYMLLQMAIMVVVALGLDKDGNFRTQTIPFDKRGVDQTEGHGDHWTPAGQRALLGCYYLCLKSSLFRRQFIMRHTEWIERCTKMLAERTEYPTDLFLRTYIDVRSLAQISQSLFEGRTPSSVQGMDWQQLFGLTEVREKRTEELLRQYNLWDNWALRMELSAIPVLVLGHALGRHKDVFHLHSTRELSYLTSSAYNTVNIFLTIPSTGFVHLPASSYNTLRYSLMVLSKLSLLSETQLEISQIRKDNMREIGLALIRKLGDISQDEDVWANCNKVVGSMLLWLENNSSQGHLTQVPRSQGINSGPYPHLELLLAPQFGPSAFPGDVRDDWNAGIWEQMLEELTWLGPSAEVRLCTGPSLSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRE0</accession>
    <name>A0A317WRE0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_515324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467937.1">
        <property type="nucleotide sequence ID" value="XM_025609917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRE0"/>
    <dbReference type="STRING" id="1450535.A0A317WRE0"/>
    <dbReference type="GeneID" id="37112060"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="361" mass="41410" checksum="DBA0706A7BA499E3" modified="2018-10-10" version="1">MAEPSPSRMHARVSKPVFLGLLWTFTWTAFLFILFRIAVRYGSFRRLYLDDFFVLLAWVMMLTSAIIWQIEGQVLYDVYGMDAGKQPYTPDVIHKFVNFLRFVGPLSIIFYSSLWCVKFSFLAFFSRLGSKIKSHRIWWSVVLFVTVALWMVSVTDIDFRCSFGSPEFLFTQCPNLYHIHFQYRVLWTNCAGDVLTDLLILSIPVFLLWNTRITFRKKVILLSVFSVTVIVMVVSIIRMAVNPSLDTPFDISWSYVWSFVEMGTAIISSCMGSFRQLFVTSQNQHLFRKAASQKPQHPLLNSVRNLYTRTQSGPGVEGDVESQKGAVGANLVPLNAVHVRSDFDVESAPASLTPSRERVWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSN9</accession>
    <name>A0A317WSN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_574771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468113.1">
        <property type="nucleotide sequence ID" value="XM_025615037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSN9"/>
    <dbReference type="STRING" id="1450535.A0A317WSN9"/>
    <dbReference type="GeneID" id="37117180"/>
    <dbReference type="OrthoDB" id="550577at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11318">
        <property type="entry name" value="AmyAc_bac_fung_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000024">
        <property type="entry name" value="Cytoplasmic alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013776">
        <property type="entry name" value="A-amylase_thermo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015237">
        <property type="entry name" value="Alpha-amylase_C_pro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006968">
        <property type="entry name" value="PRK09441.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006969">
        <property type="entry name" value="PRK09441.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43447">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09154">
        <property type="entry name" value="Alpha-amy_C_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001021">
        <property type="entry name" value="Alph-amls_thrmst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="7">
        <location>
            <begin position="41"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="537" mass="61386" checksum="5257B8864A4C0462" modified="2018-10-10" version="1">MPSLLSWCQPGKRKEKRLWKEIEEEAEHLDQHPSWDAPDNSLMLQAFEWHVPADQGHWRRLQHALPGFKAIGVDNIWIPPASKGMEPCGNGYDSYDLYDLGEFEQKGSCATKWGTKEELQSLAARAQDLGIGIYCDAVLNHKAGADYTERFPAVKVDPQERNTEISSPEEIEGWVGFNFPGRGDRYSSMKYNCQHFSGVDWDQIRQRKGVYKIEGHNWAKDVASENGNYDYLMFADLDYSNAEVRNDVLNWGEWINTQLPLSGMRLDAVKHYSVGFQKEFIDRLRATVGPDYFIVGEYWRYEARPLLDYLKQMDYKLSLFDSALVRRLSMISQVEGADLRNIFNNTLVQLRPKNAVTFVANHDTQPGQALATPVASRFKPLAYALILLGDKGQPCVFYGDLYGLQTDVKDPMTPSCKGKLPKLTQARKLYAYGLQRDYFDKANCIGFVRYGNRRHPSGLVCIMSNAGPSRKRMYVGRRHATEQWTDILQWCPQTVVIDKKGYGEFPVSAMSVSVWVNSSAAGRDSLQYQFDNDIYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT37</accession>
    <name>A0A317WT37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_64289</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467871.1">
        <property type="nucleotide sequence ID" value="XM_025617567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT37"/>
    <dbReference type="STRING" id="1450535.A0A317WT37"/>
    <dbReference type="GeneID" id="37119710"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="691" mass="77509" checksum="F22334E74B790AC6" modified="2018-10-10" version="1">MPPRKLRKGTHSCWECRRRKVRCQFSSPSAAICTPCSIRGSPCRSQDLVDSPPPQRERTHAQRLDRLEELMQRLVERILPDGDVAERRPGEGWFDAASSIFSTSGTRDAFRVAQNVDTPGIDETPVGLLLGPGSDTSSALTPELGGSYSSLGSGIAGINRVSQRLHALFPSQEDMKLITESSPGTIFLAALFSSDSDGISAIYNSTEDIATIPQISSQPTMLAKRLLQLAICMQQLSPSFDTRRLGLKVPVATIMVHIDSTISNLVISNDDYMANVDGLQCIILHGFWHMNAGNLRKAWLTFRRASSLAQLIGIGPGSNDSNARKTKENLTPFHNKIWYLLAAFDRHLSLFLGLRIDMRDVSFASEEWTKYDSPEEKLEKLHTVIAARIADRNHTTNEGYAIMQAIDYDLDMGAKRMGQMWWSHSSPVCETPEQNWQHRRRLMIQINHFGLLVMLHLLYLLRDPTEHRYTHSRMTCIRSGREILTRFISLREDVESIFSCRHIDYAASIAAITLLLSYLVQGAIPVSDSQRENDRIVIGQVKDRMEQVVLLNDDKFLQESSHIISQLLPVLDTDSTNKMTLSAEDNLGETVQLNIPYLGLVSICLKPKQRAKPTSSVERSDQQSRSASLSHEQHANDWNIHEFIHVEEAFDGHLPTLTAEASDWPFQGIDTNFWSLLQGGIVDSDGFNPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WU67</accession>
    <name>A0A317WU67_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_534131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468282.1">
        <property type="nucleotide sequence ID" value="XM_025611472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WU67"/>
    <dbReference type="STRING" id="1450535.A0A317WU67"/>
    <dbReference type="GeneID" id="37113615"/>
    <dbReference type="OrthoDB" id="4225201at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="240" mass="27103" checksum="CA2B5E467424A31C" modified="2018-10-10" version="1">MARCGDLPSQLLPEKKNVSAISHSTLKVRWLAALIKKLSALTMRDYFINLAVLACIIVTFALAYKICSKTMRCQRCRVDRAAQREERQARRAYKAAARRHKWRQWWEGKICHKSETMPMTPLAYDLPDRDLEQGLQSDAESYVIEPVNLQTEIQDFRQALEYVGDLFRESVTHPYENKVGEKTRLYKMESAGSDTAASSTVGLATIMSTGSSSLKSLDCKSSVTLDTLDSMESPPPSYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WV26</accession>
    <name>A0A317WV26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="12" type="ORF">BO94DRAFT_47633</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WV26"/>
    <dbReference type="STRING" id="1450535.A0A317WV26"/>
    <dbReference type="OrthoDB" id="3356905at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SMP-LTD" evidence="11">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY88688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="437" mass="47559" checksum="0DB4AB010206E592" modified="2018-10-10" version="1">MSIEVDWGAATSGPDGEALAERIRSFIHDKFQQVALPRFIRSVQVHSFDFGTIPPELEIKDLCEPFADFYEEDEDDDEASDISEGLVSGHGAQWHGSHSELDESPFRDENAMHQPLRDPFTEGFQPSALRSPIAFGDHLNPHFLPRAGTPGIPGGTSTLGYHLMSLGGLSGTQTPLAAVAGGSPFASGWNDSGMMGPGNRGCPPPPIFNAHQSRPEADIDSSNPTSRPSTSSTLPSHPSGSNKNTGDGAGSADHGSHPEEHGHMDDPSEEPLRFPRMRERRPEDFQVLCHAKYAGDVRLSLTAEILLDYPMPSFVGLPLKLNVTGITFDGVAVVAYIRKRVHFCFLSSEDADALIGSDQQDVGGQTDYSRPGGDATVSAKRQGGLLQEIRVESEIGRKEDGKQVLKNVGKVERFVLAQVRRIFEEELVYPSFWTFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWL8</accession>
    <name>A0A317WWL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_489640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468669.1">
        <property type="nucleotide sequence ID" value="XM_025609095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWL8"/>
    <dbReference type="STRING" id="1450535.A0A317WWL8"/>
    <dbReference type="GeneID" id="37111238"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF43">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016403528" description="3-phytase" evidence="5">
        <location>
            <begin position="21"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY90291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="577" mass="65232" checksum="D3A4CE5249F93288" modified="2018-10-10" version="1">MTTTIGWFGLSLLAASCVVAHDQYVMGVAPTTTTEPDWFKTRPQSFQGYTATGAAPFLAQTNPAPFGDAATYTVNDPLETSQPIHGAKNRNFFHHMGNLSPYYPRADGFGVDEYARPKGSNITQMHLLHRHGSRYPSKEETDRLANWAKNIADAIAHGAVFKDELSFLHDWSYTLGAAILTTRGRQDLFDSGVLNFFNYGHLYTEGTKIVARTTTQDRMLKSAENFLSGFFHLDWDQHVNLLAMIEEKNYNTSLQAINACPNAINMSFGDYVDTPLKKWKSHYLSHRTKRLNNISHKRTWTINDSFNAQALCAYETVALGYSPFCDLFSFTEWEGFSYAFDITFAGYSGFQCPIGRASGITWVEEFLARVENREFSTPGSSTSANLTLNTNPVTFPTNQTLYFDFAHDNILTSVLTAFGFRQFADLPLPDFLTTNPSSQSQSQSQSQSEPQFRPPPDRSFQTSKLIPFAARLNIEIIDAPHKITRNRTHTNQDPYLKDTPETRYIHFLVNQRTVPLHKSFPEDCPYRSDGWCELEAFLEVQRQSLDKAKYDYSCIGDWKLGDFGEVQDGVPLDSWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWX3</accession>
    <name>A0A317WWX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-glucose 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_533888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468779.1">
        <property type="nucleotide sequence ID" value="XM_025611418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWX3"/>
    <dbReference type="STRING" id="1450535.A0A317WWX3"/>
    <dbReference type="GeneID" id="37113561"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005996">
        <property type="term" value="P:monosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000418">
        <property type="entry name" value="UDP-glucose 4-epimerase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF3">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY90401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="428" mass="46619" checksum="59B65F67A3A5D069" modified="2018-10-10" version="1">MSSSIFCPSEGDSPVPTPLFSAPATPDTERDEYFDEPSLSLASQNPQYILVTGGLGYIGSHTSLELLKAGYNVIVVDDLSNSFRHVFDRILLAAKLHFDRAGGRCPRAELNCIDFRDIPAMTALLASHTAVEGHRSNITGVIHFAAYKEVNDSLRNPLKYYQNNLSGLVDLITLLDEHNIKTFIFSSSANVYGTLAQDHGSLREEHCVHRRETYLDPTTGEEISTEQGCTGITNPYGRTKFFGEAILSDVAASDPSWTIIGLRYFNPIGCDPSGLLGEDPRGVPSNLVPVVVQVLTGQLTELAVYGTDWATADGTAIRDFIHVSDVARGHTAALAAALTRQVRTNFRAFNLGTGSGHSVAEVVSAMEGVVGKEIPKRVAERRPGDVESCVAVAERAGRELGWMAERSLVDACRDLWNYLRMGEMEEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WX51</accession>
    <name>A0A317WX51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_463340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468983.1">
        <property type="nucleotide sequence ID" value="XM_025608019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WX51"/>
    <dbReference type="GeneID" id="37110162"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23340" checksum="2CADD202B69CF823" modified="2018-10-10" version="1" fragment="single">NPLFHPTITTTRSPLSECDYNTHKSNSTYFTDIDISHASLRARLFGSCVSLRPISASSIVMILGGVQCVFRREIKPYQAYELHSRVLSWDGKWVYLVSYFVDCGTPANGDGDGNGDGDGKRGVFAACVSRYVFKQGRRTYPPERMLRDCGLLEKRAVSPVMEEVGVGVGGDVDVGGGGGGGGLMEEIEERRARDLEKAQLKVGWDAVFEAFEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WX63</accession>
    <name>A0A317WX63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Stress activated MAP kinase interacting protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_33753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468299.1">
        <property type="nucleotide sequence ID" value="XM_025607012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WX63"/>
    <dbReference type="STRING" id="1450535.A0A317WX63"/>
    <dbReference type="GeneID" id="37109155"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000263">
        <property type="entry name" value="Stress activated MAP kinase interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056385">
        <property type="entry name" value="UBL_AVO1/Sin1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23164">
        <property type="entry name" value="UBL_AVO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="371"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="AVO1/Sin1 ubiquitin-like" evidence="5">
        <location>
            <begin position="610"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="732"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="532"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY89388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="92039" checksum="AEAECD6C432E585B" modified="2018-10-10" version="1">MSLLHNEDFTIWQLRTSYLSTIKDGIGDRLINVNNTVLNTPGFRAAGWSSASTNPNTQSAAAHIKRTYSPPIPTTTAVASEYYQLGVARDASDAQRLGLGDDADDDEGGMVTGKTNTELIGRRNRGKRVHRRERQQHDHQKHREAEEDDSSDLSDESDDDGDSARSAANQIKFMKMPIRTRAGSSPIRSSDRQESPQVMVTSPSHPTIGTHYRTGSLGTAVSSINERPRRDTTTTVSSDISSDNDLDASAFKRRQIQFSGHDQVIEPTRKRHGPPGPRDLEELNEQAEDSGAESVGSALSSEFDATAGSASLLAGVGITGSLDSSSPIALMHKLQNGTSSQTASPRKPKVPAPELQDLPPPRPISTVQPVSLLSKALNARKKAPTNPAEKFAVLSGKGLNDVLNIKLYLPFSADPDEPLDLPITRESKLAEQPAPVTVVEAIGLALWRYTEEGREPAVERSKLTVNMWTLRMVEDGEVEYDFPALGRTSPIADFTSNNNRAAGRRTRGKQYDEFALVEASKAEFEDNERLFPMFSLAPPPDDSGEAATTTTAPTSQPVPPNKAPRQNPILGQPFSSALNDNTLTPADRPAVPTSHATPRLGVSKTLKIRFINVEASTQVTTLNTSTDSYIAEILDSVCKRWGLDKGNYLLKVMGSNTIAPLDRTVEALGNITELDLVRRRFGPQSLTGSPGSSSPNAPLLIDSNSAPSKKGKKSGQRMLHPLTQKQDLTGGYYRRYYVWRKQSMSFTASNHRILTFDNDYMHIMPADTGKTASDTKTRSISFSDVVGCKVSRRHPKNFRVVVLRGNEANEQKRYDFEARNALEAVEIVDEIKKNMAHYRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYB8</accession>
    <name>A0A317WYB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyubiquitin binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_533536</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469122.1">
        <property type="nucleotide sequence ID" value="XM_025611350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYB8"/>
    <dbReference type="STRING" id="1450535.A0A317WYB8"/>
    <dbReference type="GeneID" id="37113493"/>
    <dbReference type="OrthoDB" id="10265988at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.870:FF:000003">
        <property type="entry name" value="Polyubiquitin binding (Doa1 Ufd3) protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000377">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000236">
        <property type="entry name" value="Polyubiquitin binding protein (Doa1/Ufd3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="232"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="7">
        <location>
            <begin position="371"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="8">
        <location>
            <begin position="499"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="783" mass="84355" checksum="DB934E4654DCA64F" modified="2018-10-10" version="1">MPEFKISASLEGHGDDVRAVAFPNANVIFSASRDATVRLWKLVSTPPPTYDYTITSHGSAFINALAYYPPTPQFPDGLVLSGGQDTIIEARQPGKAADDNADAMLLGHTHNVCALDVSHEGGWVVSGSWDSTARLWRVGKWESDVVFEGHQGSVWTVLAYDKDTIITGCADKHIRIFNTSGTLLKTIKDSQDVVRALCKVPASNPTGAHFASASNDGVIRLFTIQGQLVGEIHGHESFIYSLATLPSGELVSSGEDRTVRIWEGTQCVQTITHPAISVWSVAVCKDNGDIVTGASDRITRVFSRSQERMASAEVVQQFEKTVKESAIPEQQVGNINKDKLPGPEFLRQKSGTKDGQVQMIREADGSVTAHTWSAASREWIAVGTVVDSAASSGRKTEYLGQDYDYVFDVDVEDGKPPLKLPFNVSQNPYEAATKFIQDNELSMNYLDQVAQFIVQNTQGATLGQPSQDQTPAGADPWGQERRYRPGDVQSPPVPEARPKILPQKSYLSIKSANLKVIAKKLQELNEHVISSGSKDLSLSPSELETVATLCGQLESSNIEQSPAVEAGVVLLYKVATVWPAASRLPGLDLLRLSAAATPVTATADYGGKDLISGIQSSGVFDPPLNVNNAMLSIRMLANLFETDAGRDLAMSRFDQVLSGVKSALTNSGATPNRNLTIAVNTLYINFAVYLTSGGREFIPESSERALVLLGELTAMIIGEKDSEAVYRGLVALGTLVKGLGEEVRTAAKEVYDVGDVLKNISSSGLGKEPRTKGIMGEIRESLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYC5</accession>
    <name>A0A317WYC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_462830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469144.1">
        <property type="nucleotide sequence ID" value="XM_025607990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYC5"/>
    <dbReference type="STRING" id="1450535.A0A317WYC5"/>
    <dbReference type="GeneID" id="37110133"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="236"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="484"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="556" mass="61746" checksum="2010858F231E5595" modified="2018-10-10" version="1">MKRKHSGPDDQVPISTPKRQRAAAANGTVNGHTEGEQSPETTPSKRVKSTPQKPAAETPAALKASGLRTPTHKGKAKALFSTPTKKTAVASPTKARADRSAKKKSARLLLEQNDEDVWDGADRLAEEILEDDNEVQKQASTTKKGVLESIEEEPGQPATSDGAAPTPKRRAGRPKGAKNKRSPTPEGELPAHERYFFQNRAGPPRTSNNNLGKMTLLTHEEYFEKMSQYVDPYKQEKSFLLDLHCRSFPQWDFEFDQGFNICLYGYGSKRRLLQEFADWLYHRHSSASRSVVVINGHTPNISIRSIFATIVTAVLGADIPSKMGSQPQEVLELLQSVLKTRASQKPITVLINSIDAPSLRRAANQALLARLAATPKIHLLATADTPNLLLMWDLSLRDQFNFVFHDCTTFSPFDTEFDVVEEVSTLLGRKGHRVGGKEGVEFVLKSLPENARNLYRLLLTELLSMADEGHLSDDDGDGGQAADNNREETGIEFRLLYQKAAEEFIASSEMMFRTLLKEFHDHQMITSRMDTSGMEILGVPLARDEMEGVLEDLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZX3</accession>
    <name>A0A317WZX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Siderophore biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_397389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lysine N-acyltransferase MbtK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469303.1">
        <property type="nucleotide sequence ID" value="XM_025607372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZX3"/>
    <dbReference type="STRING" id="1450535.A0A317WZX3"/>
    <dbReference type="GeneID" id="37109515"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000104">
        <property type="entry name" value="Aerobactin siderophore biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31438:SF1">
        <property type="entry name" value="LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13523">
        <property type="entry name" value="Acetyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyltransferase MbtK/IucB-like conserved" evidence="3">
        <location>
            <begin position="344"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="514" mass="58174" checksum="013FA4D4E560BA47" modified="2018-10-10" version="1">MRNHMCHLPNGQSLTVSPVFGGFTFKSNDVNPTHSIVPPGWNIVLSTNRPDTDVESHDGDQGRARDDEHRARVTRFTTPTLRDDFLYISYIVDPPSSDYKPVSSPTRQIAMMLWVTLWWYFHEPPPDSRLQTDASANTPAAGQPKGDWRVYIKREGFFKGRTLLQKLERMGLIASEDSSVGAEPYDPQAWANMFISQRSFWQIDPRLFVFTLSPQSIPQAVSGSPFIQRVASPSRDSFNLSHTAGQEIAHYIPNEGPFASTSHLPTYFPPPPTQYTFTNGVRHPIRPKPPHQGDVFYIRYIPSVQQYLSFRVPYLPSAHRVPASGPGTPTPGHTPNLSTSSLDQPLSAGPSDLDLLHKWMNDPRVNASWGEAGPIEHQEKFLRTNLNSKHSFPVIGCWDGKPFGYFELYWVKEDRLGPLIGGADNYDRGIHLLIGEQEFRGPHRVPIWLSALVHYCWLADSRTQTVMLEPRVDNVKLITYLQESGFYKEGEVTFPHKQSALMKTKRDAWESPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0C5</accession>
    <name>A0A317X0C5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenol monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_533906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468806.1">
        <property type="nucleotide sequence ID" value="XM_025611423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0C5"/>
    <dbReference type="STRING" id="1450535.A0A317X0C5"/>
    <dbReference type="GeneID" id="37113566"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="40"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="475"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY90428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="73563" checksum="A08FC3C21BAD37D1" modified="2018-10-10" version="1">MPVFTECAASTRELRVLPSFAPPLPRFTPDFPHDGHSERYEVVIVGAGPAGLMLNLLLARYGLTDESLLCVDAKPETLKSGQADGLQPRTLEVLKSLGLVDEILSDGCHMEEVAFWNPSPNPDEVIERTAIVPDVAVPARFRHEITIHQGRIERILETDLLRYSKRGVQRNTRLLKVTIDEDGDAEFPVVAEIETDGQQRTVRSKHLVGADGAHSVVRRDMGLNLVGESLDHIWGVVDLVIDTDFPDIRRRCAIHSPAGSVMVIPRERIATGDYLTRLYVQVPEEATPDDNHKPANGTTLKDARARRGQVTLDGIFQHAAEAFKPYYIRPKEAGVVDWWAAYQIGQRVSNKFTVKDSKGINRVFIVGDACHTHSPKAGQGMNVSMMDSYNLAWKLVYAIHGLTADSSSGKPDAVLDTYHTERHTIAQELIEFDRAFSSMFSGKIGGAENGVGSLTHEQFLEVFSTGNGFTSGCGIEYPDNPTVQKTLSQDKKNPVEGNDYLSGILRPGRRLLNVQYRRHADGNRRHLHDDFLSTGRFRILCLTSADLLDPKGVSARTLRTLGSFVLPRFPSVIEQVVIHPRLPRDFTWRDIPAELKKHSEMSFYSGYEMDDVYKIYGVDIAQGALAVVRPDGYVGTVAALDDVKRVEEYLERCLRTVQTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1E3</accession>
    <name>A0A317X1E3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M protein repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_544753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469095.1">
        <property type="nucleotide sequence ID" value="XM_025613195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1E3"/>
    <dbReference type="STRING" id="1450535.A0A317X1E3"/>
    <dbReference type="GeneID" id="37115338"/>
    <dbReference type="OrthoDB" id="5413982at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1480.30">
        <property type="entry name" value="Designed four-helix bundle protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313:SF0">
        <property type="entry name" value="TESTIS-EXPRESSED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23313">
        <property type="entry name" value="TSEC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="693" mass="75988" checksum="05B6580FF8BBCD3A" modified="2018-10-10" version="1">MADDEERIKAEKLAAAKKRVAQLQKQKKKANKKVASVDISKDGAAESSEPVKDVVATPSPISTPPPVVEGEGESPVADAPAPVVEEEAKVEETGTGTGSDEKVEKSEEKTGAAEDKKEAEAETGTESPAEVEPMPDAPTSPGPEAEVQPAVIGRSAHGRQPSLSIQSKMRSSSFRKGSVSQGSVSPSPGAMLKSPSLPPLSADGESVQEVYRKQSTRIEELEKDNKRLEKELEETTGRWKKTDEQLEDLREASVDVAELKDKLQKAEERVAEIDELKAEIASLQRQNSHLQTRTHRSNASVSVPAPSESPPADLVQQLESKSATIEAMELEISNLRAQLSSSSAHEAQIAALEEKLSGSESALEKAQNELADTKSALTRASEKAVKEGVDKTSTETLIKNLQREIDELKQEKTGADKKTETLEKKLEAMGNLHKESEARHQTRLRETEKIEKEAAVLKKRLADVENENLRLKEEQEALRKRQSGDGGADDDALDELEDEERSRLHRRIRDLEGEVFDLRRGVWQERREELAGDHQLHSPFPPDHPASTAASAANTFDDVDLIGGTPDHSRRRSMANNKNQHSSFSTVLSSGIAAFTGGNTFYGNRARAASNQQHHPPAARGSLELLSEENFDDEFDEAEFARAQAEEEARKRVEWVREIKGKLKDWHGWRLDLVDSRAGAEGAGVGMGEIFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1Y8</accession>
    <name>A0A317X1Y8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_533711</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469295.1">
        <property type="nucleotide sequence ID" value="XM_025611380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1Y8"/>
    <dbReference type="STRING" id="1450535.A0A317X1Y8"/>
    <dbReference type="GeneID" id="37113523"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="17">
        <location>
            <begin position="519"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="527"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY91567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116288" checksum="EA7B9CD2B550A0B1" modified="2018-10-10" version="1">MLRSSLGVGRGRIPALQKPGRLLRSDSVLLRWSPIRRSASTVTSLDNFPEIGEGIHGFTVQEKQHVPELHLTAVRLKHDKTDADYIHVAREDKNNVFGIGFKTNPPDATGVPHILEHTTLCGSEKYPIRDPFFKMLPRSLSNFMNAFTSADHTTYPFATTNQQDFQNLLSVYLDATFHPLLKEEDFRQEGWRLGPEDPRAILAREEQSQGEQRPEDILFKGVVYNEMKGQISDANYLYYIKYKESIFPALNNSGGDPQYITDLTHKQLVDFSKRNYHPSNAKIFTYGDMPLSAHLEQIGGVLDGFQKGEADTAVKLPVDLTQGPQSVTVSGPIDTFASEDKQHKTSTSWYMGDSADVVETFSAGILSSLLLDGYGSPLYRALIESGLGSSFTPNTGLDSSGRVPVFSAGVTGVSEEEAPKVKEAIQKVFEGCLSTGFSDEKVRGFLHQLELALRHKTANFGIGVMEKTISSWFNGSNPMKELAWNEVIDEFKRRYEKGGYLESLMQKYLMNDNCMTFTMVGSPTFNKGLDEQELVRKEQKLNQLIEQHGSLEKAIAKLTEEELQLLKIQEEAQNADLGCLPSLQVADISREKERKPVRESKVDDVDVVWREAPTNGLTYFQALNAFEDLPDDLRLLMPLFNDCIMRLGTASKSMEQWEDLIKLKTGGISTSSFHTSSPTQLGKFAEGLQFSGFALDQNIPEMLEILTTLITETDFTSPSAPAMIQELLRLTTNGALDAVAGSGHRYALNAAAAGLSRSLWVQEQQSGLAQLQATANLLRDAETSPERLAELIEKLRLIQSFATSKSSGLRVRMVCEQNSAKQNESVLQKWLAGLPQIRSPTSTPSSTAIGLGANKAFYDMPYKVYYSGLAMQTVPFTNPSNATLSVLSQLLTHNYLHPEIREKGGAYGASAMNGPVKGMFAFTSYRDPNPINTLKVFQNSGVFARDRAWSERELNEAKLGIFQGLDAPMSIDEEGARYFMSGVTHEMDQRWREQVLDVTAKDVNEAAEAFLVQGSQRSVCLLGEKKDWVESEGWDMRKLSMNVSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X489</accession>
    <name>A0A317X489_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_510914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470180.1">
        <property type="nucleotide sequence ID" value="XM_025609747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X489"/>
    <dbReference type="STRING" id="1450535.A0A317X489"/>
    <dbReference type="GeneID" id="37111890"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="607" mass="65646" checksum="C1B6B3195805BF53" modified="2018-10-10" version="1">MSNSTTRPVPGTHHLIYLLLIIPTGLSITVLLSDSRRWTLTGDLYTFINTYRTSVQTAIQILATLLGTIQLVTICRLINNATRILFTRPTHHTTLNHLALWSSLSTPTTNFSLPLPQILLTLILANLSAVLSALWTGALTPTSATTTTNTTIHIPSYANRSFIKEYPSQIDNTGPSLRTTHGYFTYSVGVGLLTSLVSSASSASPLTGTLRNRTHSKLDSTGYTYTGRSYGVGAPVGLTDSSVSLYPWASNYTYRERGYDAQISCIYNASSLFILQDTYYNALFDARGPLPDSNSSSGEYSVYTGWSTDTIVALGVASDPIAYTKSRYVAAAAGESYLALNASQCVVTFIPTWFQVSVAVKDKEIYVSRINSSSLDPSEKQDEIDIDPTNRTIHVAMRQLELISNDLTSFYRSTLGDAFNTSIADYTTNVNSSSISNTTAALTGIKNAYISLVDDILESYAAAQLVVGNFTAPATATVTIDALRLGSRVYIVAVFVVSLVVVGVVGVEAARTRGWRGLPGFDFLDGRMLVLGAANGGRGIAERAAERGWRSTGGIGVRLVGVGRQGWALVWGERLDKSRRKGEKEKLGHAQGRGRRGSQETLVDGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4I3</accession>
    <name>A0A317X4I3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_486600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470237.1">
        <property type="nucleotide sequence ID" value="XM_025609011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4I3"/>
    <dbReference type="STRING" id="1450535.A0A317X4I3"/>
    <dbReference type="GeneID" id="37111154"/>
    <dbReference type="OrthoDB" id="5223508at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="287" mass="33405" checksum="261D272A8686E531" modified="2018-10-10" version="1">MSLFRNCRTATVQLRGFASSSSLRVGPESPNFIDVPRTIQPDLPPKPRVKGTLPVPRELFPVRRKDKPTEEYIADATPLPTKEISLDPKDPNADYIEWKKIMAEMRRRNLREGLLELHARKQRTDKTMMKRSLEKQKRRERIFRQPEREDVRLTRTSVIQDMLPKHTPMLPDPDREARLAQSQERVEHRQAMKELERQEHLQALYMNARNFITTEAQLLAEIEEVFPDGANSAWRSDHQDGNNIWNLGVPPTVHSIVNDSNKSETGRWYVSQERLNQIAEQLTGGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4J6</accession>
    <name>A0A317X4J6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_616177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470026.1">
        <property type="nucleotide sequence ID" value="XM_025616799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4J6"/>
    <dbReference type="STRING" id="1450535.A0A317X4J6"/>
    <dbReference type="GeneID" id="37118942"/>
    <dbReference type="OrthoDB" id="4192850at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="222" mass="25776" checksum="7435524C6EC231DD" modified="2018-10-10" version="1">MSTLATMPLTRQNRALFADYGVDERALVIPENLKPIMPAGIQDEMMKCLHEAIAVLQARELYRPRFEQKYAERFDHLCSAGGEIYKQHMESVRAIQHCVPPRKIPKNMVHLTPFGHDYGVFVYRENMALKYVELGKLPKYNDAVDRVEAIMKDELVGDACMASLSWWRSVFLGEMRKLIHGRERMYMPTQEATVKEFCELIRERVEDGDQVAERFEREAGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X581</accession>
    <name>A0A317X581_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_622112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470517.1">
        <property type="nucleotide sequence ID" value="XM_025617045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X581"/>
    <dbReference type="GeneID" id="37119188"/>
    <dbReference type="OrthoDB" id="4432475at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="80" mass="9022" checksum="6BD6C0E54B2F2E4D" modified="2018-10-10" version="1">MDAIRQNIESAKAKGKEYYDSMMGEQSNTSSGSTNYTDQAKDYYNKMMGQGSEYTDQAKDKANDLMDQSKNYVPESKGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5A2</accession>
    <name>A0A317X5A2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">3-methyladenine DNA glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_351064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470504.1">
        <property type="nucleotide sequence ID" value="XM_025607103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5A2"/>
    <dbReference type="STRING" id="1450535.A0A317X5A2"/>
    <dbReference type="GeneID" id="37109246"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="202"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="383" mass="41488" checksum="84B9EA9135655748" modified="2018-10-10" version="1">MMTLRRSARLSAVSNTPIPVLQPAIPIKRANRPASTNGVSKARKPTARGKKALNLKSNPKLEPPPLADTTKAPSSAAATTKTPSTNIWDPSPTDNSISRPHSTPPPLDRPVEPHRTNATLLTPHGSSLVAYPPGTEDASPSKTGRPRPIATTGTLLEKAIAHLIATDPRLDPVIKEHPCPLFTPEGLAEQIDPFQSLVSSIIGQQVSGAAAKSIKDKFVALFHTDSDGAREKFPTPEEIIKMDITTLRTAGLSQRKAEYIHGLSEKFASGELSARMLLNASDEELVEKLTAVRGLGKWSVEMFACFALKRIDVFSTGDLGVQRGCAVFIGKDVSKLKGKGGGKFKYMAEKDMLELAAKFAPYRSLFMWYMWRVTDVNITVMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X687</accession>
    <name>A0A317X687_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_532080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470875.1">
        <property type="nucleotide sequence ID" value="XM_025611047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X687"/>
    <dbReference type="GeneID" id="37113190"/>
    <dbReference type="OrthoDB" id="4961018at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58100">
        <property type="entry name" value="Bacterial hemolysins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="412" mass="45999" checksum="E0DA2775930AF42B" modified="2018-10-10" version="1">MATIASEPIDPPSLNPKSSSPTYDEVAAKVERLVGSDPTPRKYVDVVEHLTAEEVDILMTGVDKIKPIADEEEAAAYTTGAAKTLVSDECIEYLRLASNAAVDAANEIERVFVDLQLKIAQIDIIHHSGFQDELIEHERLYRRILAESRDLATDLAVHGDRFDLLIIEFCRDLTIPIDVRKTIINGFISDMEKAQKDAREVEDRFDELRISFTSFVAKFSSWAKERETELNEEMKQVLEELEDLNEQLQSHVNGLLLTAGVVGVSTVVFGLAFAFGPIGFFIGIGGWIATGVAGAAATAALLVKKTRVERQIRDKEAQRDRLEQELEDIQQARTRLVDLGHHRLDLFRDNVNVLRSIWTTVAVDARIIARWLEGSLDMVIWPPAMESSLVEGNSVYKTMAGYLKDYARGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6F6</accession>
    <name>A0A317X6F6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_324695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470967.1">
        <property type="nucleotide sequence ID" value="XM_025606924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6F6"/>
    <dbReference type="STRING" id="1450535.A0A317X6F6"/>
    <dbReference type="GeneID" id="37109067"/>
    <dbReference type="OrthoDB" id="4833301at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="499" mass="55923" checksum="DC9BE2AD932E2F65" modified="2018-10-10" version="1">MTTTLERSLSRTSSMSIPVSSPRLSLIHESTPPALTDPTLSHIHDRLTLLDSRLLELRSSVLTKDGYVDRRNREDEHIRREFEANRSVSNRIDLNVVALKTDFDQLKSGISQLKSSIGQNGNETVFLRSDVDRLSKNVDQIQSDIEHLQTDVCGCRVEISKLHATISQLRTDLITLQHETSRHLTSVFNRFSLIEARMKHSERVRFNSLAHTTHAPITPVPVVEDAGSLQWPEYFPRTVWRFWCLKKRSRINRLVQLAEFYQLGGYEYWGRMHQEQSLFASDSDSSDSSDYPSNLSRAEAVRLYPEAAHQALAATLGLVYYKIRNEVGEAPNAAIPRPPKRQQEEVVSATSSTKGKPVKMARPPTMSPTTLKRLVTGPSLESKSLTSEESDKLGWNAHSDMSDDTMSKLRGIVSDEVGTLLRALERGRIRLKSNRSERTNLSPTESKASSRNGKAIEGDEPTLPNTIATEIVPISSSNAEKMEDHELPDTASDATSPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6U5</accession>
    <name>A0A317X6U5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">BO94DRAFT_563804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6U5"/>
    <dbReference type="STRING" id="1450535.A0A317X6U5"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="750" mass="83365" checksum="E9EC6403B6B91811" modified="2018-10-10" version="1">MSAVMALNVHRVLNLTVFTLFSVVLFFCIVLTPADAIYQCYVTQRLTNIFIITGGYVVTFILAALIYTTRIYTNRTVLSGIPKAWIPVEKQDVGKSVRRLVKEGLAHSAIIAYQARPRDIATEGHDFSDYESLLVDHDSPPWGQVEHPGWSSPSCPDLPDLPYRTVVQELPHLIEAKAVSLAPPDPIFTATRRALHTPFPDTEESIPDTRVVEVLRRPISMGLRGYLQHLTALNVIDPPEIGMEFVALYERARFSSRELHEAEFRTLMHVFAELLRGMKVLDPRVLDEMWGESSRADSESLIGPSDEEGETDTVDSFEGSEAMSRGRSNSLRPSNASTWDGRSAKQGRWSPVWSRRPEPQRTLVPPRTPSMRSLRRVQSIVSGSSGGSVIRLVETRRRSFFTPTPSATPQDSPKGSPKADEVVEEFKQASSADTLFPKTDPSVDGEECLHDCASCTVKYPAKFDVDQEDNMYGNINGWSTHVLVATGKTDWVRDVADEEGSVMEAIEKGGLVPGNGKLKLSASNMPVPDEYHYHESGKQPTTVLVLPSFTIVDHVTPALAPDLIKYFVNRSPTTTTPLGAVVESMEETENAEQQPPSSEDIQSLTTLKSRPCPHSAVILLCSHRTRDARCGQSAPLLRKEFERHLRHLGLYRDLDDERPGGVGIYFINHVGGHKYAANVIVYRRRDFDWHKTAGEAETSGEGAAQGIWLARVKPQDCENIIRYTVLQGKVVKPGEQLRGGFDRATGLTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X720</accession>
    <name>A0A317X720_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_510303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470896.1">
        <property type="nucleotide sequence ID" value="XM_025609729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X720"/>
    <dbReference type="STRING" id="1450535.A0A317X720"/>
    <dbReference type="GeneID" id="37111872"/>
    <dbReference type="OrthoDB" id="4475255at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="48"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="316" mass="34432" checksum="9B25AF43715FCF42" modified="2018-10-10" version="1">MSTQETAKTLYLEANGTNYTYRIIGNRSDDSSPPLLMLNHVRSTIDTWDPFVINNLTATGRQVITYDYAGLGHSNGTIAPSIRAFALNLLAFLSVLLPTMHTPHVDVLGFSMGGYIAQQLALDSPDVVRKLVLAGTGPSLGPDLERPMTEVQSTVFNPTPGIPTIEAFFPSFTTGDEGAAWFNRSTTSRTDMAGQNGEPDIALFTTGDDLVNLTQAYLTWDADPVPYALLQTIQKDALVTNGDNDLIVPTKNSYVLARQLPRANFVMFPSSGHGHLFQYARYYTKLVGEFLDGMLPTAPFSSGNAPAFGTYGRYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7R0</accession>
    <name>A0A317X7R0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protein DskB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_531518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471330.1">
        <property type="nucleotide sequence ID" value="XM_025610916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7R0"/>
    <dbReference type="STRING" id="1450535.A0A317X7R0"/>
    <dbReference type="GeneID" id="37113059"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000220">
        <property type="entry name" value="Ubiquitin-like protein DskB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="416"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="47835" checksum="73EAAC45FFB994E3" modified="2018-10-10" version="1">MADDTATAEDAPITFTVKSSNDVKFTLTLPLSTPVSDLKEKLASSEYADTPAERQRLIYSGRVLKDNETLATYKIKDGHTIHLVKSAASNQRPGGAAPATSTAPAGSAANPPAAGVPTNLAAGTGNNPLAGLTGARYAGFAQLPGAGMFGPDGGMGPPPDTESMLNMLENPQFQSTLNEALQNPAMIDMMIQQNPMLRDMGPGVRQMMQSPEFRRMLTDPNSVRQMVQMQRAMGGGGLGGSAFPAPGVTNTTPEENRNTQNNNGTTPAPGAAFNPFMPAGLGAGNPFAALFGGNPMMGNPVGATSTAGGDQPNTTQRAAGTTTGEDNAAGQGQNQPGFQNPFSFFNPALFGGQGGQAGGNPFDPQHNPLLRDPALLQQVMQSLGAGPGEGGAAGTNPLAALLGGGFGTPPPQDNRPPEERYAEQLRQLNDMGFFEFERNIEALRRSGGSVQGAVEYLLSHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8H4</accession>
    <name>A0A317X8H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_582311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470648.1">
        <property type="nucleotide sequence ID" value="XM_025615470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8H4"/>
    <dbReference type="GeneID" id="37117613"/>
    <dbReference type="OrthoDB" id="4510589at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050534">
        <property type="entry name" value="Coronavir_polyprotein_1ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN SMUBP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43788">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="5">
        <location>
            <begin position="102"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="409" mass="45948" checksum="5D60CBA0E59C6858" modified="2018-10-10" version="1">MFAFAKVVAHVVQQANLLVCTNNTAGSPIVASNFGRNAKSIILIRDEVPKEVELNSWIPIACLRSGAKVIGMVISGDLEQPQPTVLSAQDDPVYNGFALQLQLSFFRRATKMNHPVTKLTEQRRFRDAFVGWLNKRIYNSMMKSHVSTQGLTIDPRWDAMVRDLYDLNYPLDTGNIVLSIEGSEAFVDPHSKSRLNHNILYAVISLILCCMESTAYLPTEITVICLYKAQKVLYLQALHKLIQANVLRFDALPCIETADSIQGKENRVIIVDWVVSSASKKSDLGFTIDDSRGNVAQSRMREVMVNIVPSTIGSDALSTNDQERNGPRRDLKKKKLPYLCEYVQYAAAHRMIIEVSKDRVYDHLHPEVRCFDAEELEEPKNGSVSGVPIDLDSLHEVFDREQTVPVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X904</accession>
    <name>A0A317X904_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_581426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471844.1">
        <property type="nucleotide sequence ID" value="XM_025615404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X904"/>
    <dbReference type="GeneID" id="37117547"/>
    <dbReference type="OrthoDB" id="10459897at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="110" mass="12234" checksum="E47E6FB1BC23ABDA" modified="2018-10-10" version="1">MQKDMTRVGFEPTPSNDDQEAVKLNIKVDLNLTPWTNSAILPSDVEEARYFAIIKNSAICKAKPPMTEPYLYSCTVTNGIIRAPPASTGRHRTASVHREPRQFQASESGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X972</accession>
    <name>A0A317X972_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gem-associated protein 5 TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_543446</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470963.1">
        <property type="nucleotide sequence ID" value="XM_025613138.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X972"/>
    <dbReference type="GeneID" id="37115281"/>
    <dbReference type="OrthoDB" id="7326421at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000577">
        <property type="entry name" value="WD domain G-beta repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034605">
        <property type="entry name" value="PGC-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056421">
        <property type="entry name" value="TPR_GEMI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528:SF11">
        <property type="entry name" value="FI18188P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15528">
        <property type="entry name" value="PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1 PGC-1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23774">
        <property type="entry name" value="TPR_GEMI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Gem-associated protein 5 TPR" evidence="8">
        <location>
            <begin position="530"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="348"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="816"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="932"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1391"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1458"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="844"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="932"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="955"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="982"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1028"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1085"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1136"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1155"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1176"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1201"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1326"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1420"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1475"/>
            <end position="1485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1584" mass="172513" checksum="7B65B92CB54A9994" modified="2018-10-10" version="1">MVEIPWNRNPVSDSRPSRMKPVAPPIPPPPPPPQVSNARLEPCASTASLFLYAQGSVVVCLHHDTLALERRFENHQADVEFIYVDNVSERGAGRLVVSYDVSQTAIVWDLFTGSVLARFASFEQLKVAAWMRNGNVVFGNEKGDVIIFEPSTSEHVSCRTIFDPITALAPATDCRTYAIGYQNGSIMLATLHPTFSILHTMTTSRGPSAIMSLAWHASSSKQKSDMLATLSANGDLRVWSVAKPPGKETPRVIRVLKRSDGSPASEPKWMAWSKNGRIVQFLEGETWAWDVRTKHVTYEPIPTIDNPRGFANYGPTATLFTLGPQYTVQQYDVDSPAMVANVQHVPAGSLPAPMEQPKLRTLQDPPTMRESGAMSNPRRTPFDMNGIETVRQQRADVGSPIPRSHANSVTNSVSSKASSNNYRMPFSPPSRSGQTTTSFSLTSASGRETPQASGASYAYASSVSMSSTKSSRAGSRLRNEVQLSPADKPADLFPFTRARLNDVPYGHHQPLDESCLTPDDLRRQMLSVVFGHDGDIEGLIRDELSNHPPASQSGILLAQWIGESDTDNMTSLISSGAASTTDWMLLAFSQMSGESQSNKIGQALVQKLLEIGDLHTAATILLGLGDRNDAIEVYVSQNYYMEAILMTCLVMPTDWQRQSYLVRRWGEHVVSHSQQQLAIRCFMCTGVEPSEPWTSPAAQQATSFSEVMTKRSPMTSPEPPYPNPASLMVPGSQPKPAANGRPLAKTPALKLITSFDSQPNNRFRFPGLKSDDRTPTNAPGVTPIAESAVIESALSPGGFGSYKLNNIQSINNAMNTRTTTPAFNRKRLPSIGETPIDVHPPTFPSQSVHPPTFASNPVMDYGSTSENDEGQPPPEQDGNEADDEQLGLLSSARYEPDEYKPSPQTAVQATADKFATIKGLPSPAAGVFEALMERSDSRNGTRDRKPDGLQLNLDHGNSSQTDLQVQSDMAASFRSPASTLNSFSSARSPSVSGRSIDPYISSLGEANYHAKKYQAPRANGRGRRNTDDSVSQTSARRYHSRNASQETRGRHERRYIPPAKRSPSSPVPMSPEELAQINANAAKKPTSRTRSASRVRKPRSRNSSERRQNRSASRNTATHLGTDKNGAITRGRSMDRQGSSTRSPSSPLPGSNADDALRLVASDRERLRIRQRSGSRRPEKGSGAKAEVYSESKWTRARSRSRQDAEPRASAEDATDVIISSNVHDGIYLTGYPSARNMPAETPREVPAAGVPQLSLAEKKRKELAAAELEARRLSLARNPSAPNIPFPGELQPSRTPLESPPFSVHSFAPRTPGRNRAATNTTKASPEYPSSSDSNSSRSGVPLGLPATPKAMRHPKYNGYEETAPVPPVPDSTLLSDAKYQGDAERIGRSMSVPVPESHQPGAVPTDLPMHPRFNPHLPRSRSTSRTRNRAHRDSGGYSYGGSPVTVSIEETIENAMGGQQADPPILPELQHLNPPPPPPPPTAPLASPRESSGTIDIAIDNEDFGRLLPRAMTAAPAFNMEGHPGLEHRRMSLEHRRGRSVNESLSSKIRNLARMGSTKSTDSWVASDITLPYETVIVDGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9A9</accession>
    <name>A0A317X9A9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_219764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471907.1">
        <property type="nucleotide sequence ID" value="XM_025606213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9A9"/>
    <dbReference type="GeneID" id="37108356"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="222" mass="25104" checksum="F3CC4A512DDFF8DE" modified="2018-10-10" version="1">MAAPADITLKNLNGEWTMDKTLSNPTEPILELQGMGWLTRKALSVATVTLSIHEYPDAAEPSIMHIDIDQTITGGIKGTTERRISDSKPREHQDHIFGHVRGQSQFFRGSKGEDGKARPYLEFNTKSDEPLVFKFLRGEVLADGSECEGFIVEDMGEEFGEGEGIWFQSFVENLDSGWTAEQIWGFEMIDGKRYYTRRVAVVKGKTYKLARFVYAFIKPRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9F8</accession>
    <name>A0A317X9F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_531119</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the wetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471967.1">
        <property type="nucleotide sequence ID" value="XM_025610830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9F8"/>
    <dbReference type="STRING" id="1450535.A0A317X9F8"/>
    <dbReference type="GeneID" id="37112973"/>
    <dbReference type="OrthoDB" id="2575228at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
        <property type="entry name" value="DEVELOPMENTAL REGULATORY PROTEIN WETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="230"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="378"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="504"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="266"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="555" mass="60094" checksum="F70DC1B7B2596BA5" modified="2018-10-10" version="1">MFAHQFDHSLNDLDLFNQYVNMDNSSVDGNKDVSFPGDLDQIFQLESLSSDCGEHSPAIPTSTQPHQAAHAWSKDFWCLAHDPDSSTGHPHFSLQDTVHPSAVSELAVNFEAPPTACAPETRRSPTTPPATPSRKAQSAGITPKAIRRHREPNDRRGPLQKQSFSPGIPRSSQIQRNRMAYPEAWAQRFNNFSFRNSDERLPLSPPPSDILVQQENMAADTAHLNRTEALSKPSAEMPPHYDTGIFNPSPAISMPSPSTATLAGQPPRYLSQSSSSGLPTSSPPSADEIFSSPHSSGPQSMSSWHSDSLASSGLPYSTPDLNGHDTQAWWSPITSRVPQRQPSYQQMVASPAAQRPIQNPATQNDMLQGGLMIQLDPSSFDLSNTHSSFPSSGLASAPNGHDSRPYTHSTAAPVDSSSFVTPQIPPTHSRPPSLSPGSGASPKNGTIMHNGSRRTINRQNLNRKLSNSMNMPKPVKGLHTTSPKGGNKSVTVSFVNFTPNDHQKILTGVAPSGSSKTKARREQEARDRRRKLSEAALQAVRKAGGDVEALEAIFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9H7</accession>
    <name>A0A317X9H7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_543096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471602.1">
        <property type="nucleotide sequence ID" value="XM_025613121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9H7"/>
    <dbReference type="STRING" id="1450535.A0A317X9H7"/>
    <dbReference type="GeneID" id="37115264"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="88"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="297" mass="33241" checksum="D7863591F0DABB1F" modified="2018-10-10" version="1">MLRRQARERRDYLYRRALTLRDASIAEKRAQLKASLASGKPVDPSVADDKALREDFKYDESITPADKQNKDEVDLDDEYALTSGIADPRPIVTTSRSPSVRLGTFAKEIRLLLPTSIRLNRGNLVLPDLISSANAAALTDMILLHEHRGTPTAMTISHLPHGPTASFSLHNVVLRADIPDAARGTVSESYPHLVFEGFTTRLGLRVVQILKHLFPPRETGKVGNRVVSFVNKEDSIEVRHHVFVKTGYRDVELAEVGPRMTMRLFEIRGGTLEKGSSGDVEWALTQYTRTSKKKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9U9</accession>
    <name>A0A317X9U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_456160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471752.1">
        <property type="nucleotide sequence ID" value="XM_025607688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9U9"/>
    <dbReference type="STRING" id="1450535.A0A317X9U9"/>
    <dbReference type="GeneID" id="37109831"/>
    <dbReference type="OrthoDB" id="3598281at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056024">
        <property type="entry name" value="DUF7605"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36681:SF3">
        <property type="entry name" value="NUCLEAR GTPASE, GERMINAL CENTER-ASSOCIATED, TANDEM DUPLICATE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24564">
        <property type="entry name" value="DUF7605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="3">
        <location>
            <begin position="236"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7605" evidence="4">
        <location>
            <begin position="711"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="511"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY94991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="976" mass="109032" checksum="DBCC2759F924F825" modified="2018-10-10" version="1">MTDAADNPSTTPTRSTKAVSSSADKDHPLPSVEFTLSCNPSSSDCMTPNSSADGSKGSRSSTTPTTFIFGNLHLSENISSPTQAPLINQPNIMQNGRTTYRDLHNVTPSPAGPASMRPSQQRPHTPSSPLGTVHYQFKNLNLEDGGGDVSDSNRSSIDVPEDDEATFNIRQEALPPAPIYDIRLQNVLRQVRGELTSLTQVMSRNVLVQVPDSALSKLYAQTLEASKFAYPATRTVGFIGDSGAGKSSLINSLLDQEGLARSSGDGAACTTVVTEFRSVNDTFPENYTVVASFMDYDEIRELLEELLSSVRKYYTEAFREVRTSEEQEAIKVAAQRAWDTLKSLFPHQRDFDLEFLLKEGDNAVDSIMTTLLQWAMAGLDHRPGGRDNLQHTIVAHHADQCMEHLDRLMANPEDDKPAFWPFVKLIRVYLRSPVLRTGLVLADLPGIYRITPVPLDQLTTLLRVSASDRKVPSSQLRRGVYCEYYYALYNRSDVNSQETARTAPAADAARIKDMDNKIRGLERMIAQTRSRRRQSRGGKMQSLAAEEIDLRDQKDALELQLKSFLVTRRNTSVTKSLLDAWGDRARIFCVSNKLYSDYRENDPQVHDYLSLSGVRELRQYCQSVPADAQFRATVAYLQNELPALLGSISQWGLAGSSTMTVARAEVLRDVLAKAEGTLKRSTILDGSQVHSLQRSVKKQFSDAITQHIRRSQHDWGNQAVEASLEWATWHHMTYAAFCRNYGTHQTAKQPYRCWNKEILGPGIDQLSLAWRSMLDWLEEHSQNLEDELTDVFQGVRGSIPEQCDLAPEALQNLLLNLRMRQTCIVDAVHDSKESIINVAKKIMDDTIGGHASSYIAGIMRPVYNRCMQEYGTGSDSRRKQTMHRNLKSPDIFINFARNIAADFNTTIDETFNQLDQKLYNEIANITRDLGAAVTVEGEVSEAGQHPANAEQIKRDVEACQRILGDAKKVVLELRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9V5</accession>
    <name>A0A317X9V5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sorting nexin-4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Autophagy-related protein 24</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_531064</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), and autophagy of large cargos including mitophagy, pexophagy and glycophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471916.1">
        <property type="nucleotide sequence ID" value="XM_025610818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9V5"/>
    <dbReference type="STRING" id="1450535.A0A317X9V5"/>
    <dbReference type="GeneID" id="37112961"/>
    <dbReference type="OrthoDB" id="205639at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07628">
        <property type="entry name" value="BAR_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06863">
        <property type="entry name" value="PX_Atg24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000035">
        <property type="entry name" value="Sorting nexin-4 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000042">
        <property type="entry name" value="Vacuolar targeting protein Atg24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45949:SF2">
        <property type="entry name" value="SORTING NEXIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="16">
        <location>
            <begin position="71"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY95155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="493" mass="56688" checksum="883674718A338372" modified="2018-10-10" version="1">MDQHDDFDSVSWRHEPDSDVSRPTTSGTDTEESPAYSHDINGKRRMSSAQENPQAGPLADAVDLAGIGDGVLECLVDSPLKENDGTKDAYISYLVTTTTDFKSFQKPEFTVRRRFTDFYFLYKTLYREYPACAVPPLPDKHKMEYVRGDRFGPEFTTRRAWSLHRFLKRLTLHPVLRRAPLLAIFLESPDWNAHMRLRTTRNSNSSSDGSGVPGIFDNFTDTFVNAFTKVHKPDRRFIEVREKADKLDEDLNHVEKIVARVARRESDLEADYNDLATQFRKLVPLEPEVEVPLQVFAASVEETGRGLKTLKDHTDQSYLGSLRDMEAYIISLKSLLKTREQKQLDFEALVDYRNKAVAERDSLASNPSSYYASNPLTSSPASFIRSKMEDMRGVDHEQSRRERVRKLELRIDELTREVESAKTTSEMFDEEVVREVADFERIKAVEFRDTLGALSEKHIEFYQGVLNTWERFVAEMEGDLEEDHGEQGPEESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAG8</accession>
    <name>A0A317XAG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_542902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471383.1">
        <property type="nucleotide sequence ID" value="XM_025613115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAG8"/>
    <dbReference type="STRING" id="1450535.A0A317XAG8"/>
    <dbReference type="GeneID" id="37115258"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="103"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="345" mass="38807" checksum="3EC7E9659704795B" modified="2018-10-10" version="1">MGEEDTSTSTVGRWLSQRDILAGEDSEWEQFYRRHRNIVPHLTGSIDQFRQTMHQAKMRAQQHGRPVVHGLDVRDYTAISATDVEVPLRVYKSLSPKADGAVMIYFHGGGWAMGDLDGEDNICRLLCIESSLHIVSVDYRLAPENPYPAAILDSITALHWVSDNDRTHGFDGDKIYVGGTSAGANLMVKAVVLRHLSPEIGIPIQGQLLRSPVLCSSDVHHHKMGLKSMDRYVDTPILNRQSMEQFFHWYQPGNPEHPTVSPLLSTELDRTPPSFLLICGHDPLRDEALAYADELERCRVPLRVAVYPGMPHAFWIFPELSTTKAATQDLIDGVRWLLAHSRRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAL9</accession>
    <name>A0A317XAL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_132067</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472395.1">
        <property type="nucleotide sequence ID" value="XM_025605651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAL9"/>
    <dbReference type="STRING" id="1450535.A0A317XAL9"/>
    <dbReference type="GeneID" id="37107794"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="542"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="252"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="343"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="391"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="512"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="287"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="396"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY95634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="613" mass="65762" checksum="89DF2303F84BB846" modified="2018-10-10" version="1">MASHIIGNRNSTPEASKSSLRPPSSSRNLGTHQLRASADMSGFPSPLSSRSIRPSSEVYFNQQSQANNAEDPLDRAAQQWLADIDQYETTLEEMAAATLDQDFKDELSAIEQWFRVLSEAERTAALYALLQQTTQVQIRFFIQVLQQMAKSHPMSGLLSPANFGEKDAMSNRLNDAMSKLNVDSSRSSLGRPPPSPGAKRNSGLDSSTINAMFPDAAAAIAKKKAEFTQQTGNAPPSNRNSAVFDRTSFVAPTISAPDSNTDSLGQPPVSPWAQRGSEPQPPIARPKSSSGHQPMGQFSQTPSSLRSPLPTQTATIPAPEIDAPLLSPYNVGNASWASMTNTPMTATFGQQPQQPQQNSQADMVANATAMKLAALSTVNNRIALDDARKYRRARSNDGQGKNSANASHAMAQGGLASPGLPGHNHHLVAGQLLNTQQLAALQAQQHAAMAGRRSRPTSPGIAMQGGGLGPMGFTSPQNNGFLAAYDPNNPLMGNGLSALGIGQFGLGGPEGYLSDHSEVARGRSPRGRRGSSKPPEDPTDPTLLKDIPSWLRSLRLHKYTENLKDLKWTELVELNDKALEERGVNALGARNKMLKVFEQVREAKADGKLDNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC68</accession>
    <name>A0A317XC68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_531120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471968.1">
        <property type="nucleotide sequence ID" value="XM_025610831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC68"/>
    <dbReference type="STRING" id="1450535.A0A317XC68"/>
    <dbReference type="GeneID" id="37112974"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="174" mass="20131" checksum="510E6BFE7F39D8B1" modified="2018-10-10" version="1">MSPINSLWFKWKSLRLPWRRSFLVGTDLSGNTFWEFKDKLNAGRFRRIVRTDPKTHYSDVQVSPQWHQWLRYVRAEPPSLEEQQQDIIRQVQMKELARLADERWASKPSYLDMPISQQQQQPLPATNTSDATVTQAKSPQKAPAAKQDPWAKAAAGNPGDNWQPDSWSPTSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC85</accession>
    <name>A0A317XC85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ISWI chromatin-remodeling complex ATPase ISW2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_531144</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471988.1">
        <property type="nucleotide sequence ID" value="XM_025610835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC85"/>
    <dbReference type="STRING" id="1450535.A0A317XC85"/>
    <dbReference type="GeneID" id="37112978"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031010">
        <property type="term" value="C:ISWI-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17997">
        <property type="entry name" value="DEXHc_SMARCA1_SMARCA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000036">
        <property type="entry name" value="Chromatin remodelling complex ATPase chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000022">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase CHR11 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1190:FF:000005">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000234">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.30:FF:000003">
        <property type="entry name" value="ISWI chromatin-remodeling complex ATPase ISW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1190">
        <property type="entry name" value="iswi atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.30">
        <property type="entry name" value="ISWI, HAND domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044754">
        <property type="entry name" value="Isw1/2_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015194">
        <property type="entry name" value="ISWI_HAND-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09110">
        <property type="entry name" value="HAND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="208"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="504"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="13">
        <location>
            <begin position="870"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1047"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1047"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1064"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1096"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY95227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1122" mass="128067" checksum="CBDD06AD18E9E05E" modified="2018-10-10" version="1">MAPSLAPTPGSPSQADTPMTDANLEPVTSVPVDSADAPMTGYQDTPDYTDSDTNPNTTASSVAGDAVPLDGRRRRSEAFHMRKSILGKKHGRLDESKEDDSIRRFRYLLGLTDLFRHFIETNPNPRIKEIMAEIDRQNAEEEAKAKKGTARSGGAGGDRRRRTEQEEDAELLKDERSGGETGTVFRDSPPFVKGEMRDYQIAGLNWLVSLHENGISGILADEMGLGKTLQTISFLGYLRHVCDITGPHLIAVPKSTLDNWKREFGKWTPEVNVLVLQGDKEQRHKLINERLLDENFDVCITSYEMVLREKSHLKKFAWEYIIIDEAHRIKNEESSLAQIIRVFHSRNRLLITGTPLQNNLHELWALLNFLLPDVFGDSEAFDQWFSGQDADQDTVVQQLHRVLRPFLLRRVKSDVEKSLLPKKEVNLYVPMSEMQIKWYQKILEKDIDAVNGAAGKRESKTRLLNIVMQLRKCCNHPYLFEGAEPGPPYTTDEHLVYNAGKMVILDKLLSRMQKQGSRVLIFSQMSRVLDILEDYCVFREYNYCRIDGTTAHEDRIAAIDDYNKPGSEKFVFLLTTRAGGLGINLTTADIVVLYDSDWNPQADLQAMDRAHRIGQTKQVVVFRFVTEDAIEEKVLERAAQKLRLDQLVIQQGRAQQQTKNAASKEELLGMIQHGAANVFNTKGNGGSLSTEHQITDDDIDSILRKGEERTAELNKKYEKLGIDDLQKFSSESAYEWNGKDFTDRKKDIGINWINPAKRERKEQFYSIDKYYRQALATGGRTADPKPKVPRAPKQIAVHDWQFFPPGLQELQEKETAYFHKEIGYKVPLPDGPEEELSEREAERDLEQQEIDNAVPLTEEEQAEKARMSEEGFSTWNRRDFQQFVNGSAKFGRTDYDGIATEVDSKEPDEIEEYAQVFWERYTEIQDYPKYLRVIEQGEEKVRKMNHQRKMLRKKMEMYRVPLQQVKINYTVSTTNKKVYTEEEDRFLLVMLDKYGVDGEGLYEKIRDEIRDSPLFRFDWFFLSRTPVEIGRRCTTLLNTVAKEFEADDGKTNGESGKGRGRDRDDDEAEDDDGPPAKKKTKGGAVNKQVKAVKGGSKATSTSTSRAASVSSNAAPKSRSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCL8</accession>
    <name>A0A317XCL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Increased rDNA silencing protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_455147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472632.1">
        <property type="nucleotide sequence ID" value="XM_025607638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCL8"/>
    <dbReference type="STRING" id="1450535.A0A317XCL8"/>
    <dbReference type="GeneID" id="37109781"/>
    <dbReference type="OrthoDB" id="10045710at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="2">
        <location>
            <begin position="386"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="504" mass="55212" checksum="B7C94F951D8D639D" modified="2018-10-10" version="1">MGPVGVSHHSPKLVPLRNMKSPELPESGSVKDMIGRFSDYPPPPSLKNASGNVSQSVGVIRSRTPQQIAAQLAAGRSTPGENTATNMGVSKMQGSKRTPSKRSEDNERPPLLAPKPVWATAASTASFDNILQSESELPLSDKSTQRKPVAQISPIDAARLAAKMKPRPPPVPRKPPAVASGPTSAPDNVHSKGSENHEQILRSHSSLHLKETTPAETPPVLPPRRGGSSVPRKDPTNHRLLLETNNGSRTRPSTPGTASLYTASLSNSTTSLLDSSSGLDEGAFSDAIVASSLASVRASQESKVPPPPPPQRRARSRSLKHFPHTTKQEHSNSPSPSTHLRQTLRDPSRIVEDEGYQRHKHLIRKHPHKHHEGERRRWRSEVTEKERKRYEGVWAANKGLLLPPEQQRPPEAYPPEASEMVVNLVAADIWSRSRLPQHVLAQIYDLVDGQRIGLLTREEFVVGMWLIDQQLKGHKLPPRIPNSVWASVKRISGVHIHGLPPAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCN6</accession>
    <name>A0A317XCN6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_531633</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OST4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471459.1">
        <property type="nucleotide sequence ID" value="XM_025610943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCN6"/>
    <dbReference type="GeneID" id="37113086"/>
    <dbReference type="OrthoDB" id="2124077at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018943">
        <property type="entry name" value="Oligosaccaryltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051307">
        <property type="entry name" value="OST4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036330">
        <property type="entry name" value="Ost4p_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48164:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10215">
        <property type="entry name" value="Ost4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103464">
        <property type="entry name" value="Oligosaccharyltransferase subunit ost4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY94698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="72" mass="7505" checksum="FA520A82C333B683" modified="2018-10-10" version="1">MITDEELHRLAVFLGSCAMMMIVLYHFLEVNAKEDGEDLKDTNKQSTGASAGSTPAAVTAGTSSATGGGKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD00</accession>
    <name>A0A317XD00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_455116</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472772.1">
        <property type="nucleotide sequence ID" value="XM_025607635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD00"/>
    <dbReference type="STRING" id="1450535.A0A317XD00"/>
    <dbReference type="GeneID" id="37109778"/>
    <dbReference type="OrthoDB" id="4482343at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29583" checksum="F499F5FA4CFB6C52" modified="2018-10-10" version="1" fragment="single">IVENILRNMETDTPGQSIFMNNYDNVTHLLQELNQWKQDSSIITQAGRVLDLRTGFGLWAMYFADNNPDCEVFGVDFVYMQPSSVPPNCEFHIIDLTRSNWWEMYTDISLVHINDLGGDISLLRCLLAGAFKCSMPCGVVELHGITFDLYNQKSWLYGFYKSLRAAYWKDGRRLDLPNRIPLMVEYSSDLQKRFLKTWFDGLEALALDLMTKHLGWTHETILLKCALARGELLKGTHGYLTIWNVYGSRPNINLQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDD8</accession>
    <name>A0A317XDD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_529732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473106.1">
        <property type="nucleotide sequence ID" value="XM_025610512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDD8"/>
    <dbReference type="GeneID" id="37112655"/>
    <dbReference type="OrthoDB" id="4540540at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY96345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="423" mass="45528" checksum="70B7DA8B6B55295C" modified="2018-10-10" version="1">MGMSQWELGLAWLAGPLAGTFVQPLVGILKDRYGHCQRLVTGGIICLIIALLALGWAPDLVHLGKRGPVLGKAVAITAIVALNIAIQPVQLGLRTLIIETCSPDQQTLASAWAARMTGAGNIIAQFAGSVDTRKLSLVLTGSQFKNLCLITAFSLMLTIFVLAFILRDESPISKVTVCSRPLHVSMDALRSAWKTLPQGVIGVWKVQFFSWMGWFPFLFYAATYIESHLGEISEQTREATRDIRVESLHFGPQAMLINACVSFFASLLMPAVWDYHQRSRKIDARSTLMSVWMVSQVLFGGCMIGLFLASTTATATALMGILGICWACTGWIPYALISTTISQRIAGTHSSEIATTGAPRPGLVMSLHNVSIAGPQIPAALVASLILYAVPESSSPLAYVLLVGGFSGLIGAWMILGIDSMEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDU8</accession>
    <name>A0A317XDU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_17855</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473470.1">
        <property type="nucleotide sequence ID" value="XM_025605965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDU8"/>
    <dbReference type="GeneID" id="37108108"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17476">
        <property type="entry name" value="MFS_Amf1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="32"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="503" mass="53986" checksum="EB2C5267F786BC4E" modified="2018-10-10" version="1">MAKEEEKHDASTELKDPTQQGPPKSLGKEIAFIGVVCAAQFMTQAGLSLAIAPLHIISDSFGASPKDLTWASAAYSLTVGTFILVAGRLGDVYGHRLLFIIGFSWFGLWSLLAGFSVWSNLAFFNCCRAFQGIGPAFLLPNAVAILGRTYPPGPRKDMVFSLFGATAPGGYTVGATFSSLLAQRVWWPWGYWIMGIACFIFAGLGTLIIPPTPREKSQDDGISVFARLDVMGAATGIAALVLIKFAWNQGPVVGWNVPYTYALLIVGVLMLVGFLIIERKVPCPLLPKSFFKSEVAWVLGCIAAGWSSFGILVYYYYQFLEVIDGNSPLLTTAKWSGASASGACAAVVTGFLLGRVPPSIIIFIAMLAFMVGQVLLATIPVNQIYWSQAFLVMLITPWGMDMSFPSGTVIMSNAMPREHQGVAGSLVNTVVSYSISLGLGFAGTVESYVNDGGRNTLKGYRGASYMGVGLAGLGVLLATCFMLVTRFRRGNCVQKRCQPKQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE67</accession>
    <name>A0A317XE67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_12467</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473232.1">
        <property type="nucleotide sequence ID" value="XM_025605595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE67"/>
    <dbReference type="STRING" id="1450535.A0A317XE67"/>
    <dbReference type="GeneID" id="37107738"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.360:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="12">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="11">
        <location>
            <begin position="166"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY96471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="258" mass="29049" checksum="AFD88BD845B288D5" modified="2018-10-10" version="1">MLPSQLNGSPKRANPFSRASPSPTPSPQTRTVRPKSAVVTSSHKFEEARGQFRNSISQSPSSLVVRTTNRQRSGSIRNDVASGTFAPDFIKSEELRRGADQIRGQEGDNDFSGNKYVWLRDPEKAFVRGLVLEEQEGGRLLVQTDDGEQREVDADQVDKVNPAKFDKADDMAELTHLNEASVVHNLHTRYQADLIYTYSGLFLVTVNPYCPLPIYSNEYVKMYKGRNRDENRPHIFAMADEAFRNLVEEGENQSILVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF86</accession>
    <name>A0A317XF86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_12491</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473233.1">
        <property type="nucleotide sequence ID" value="XM_025605597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF86"/>
    <dbReference type="STRING" id="1450535.A0A317XF86"/>
    <dbReference type="GeneID" id="37107740"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY96472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="251" mass="28803" checksum="8C56E8E45FC848FF" modified="2018-10-10" version="1">MARNSEKAQSMLFRFRAQQAADLGIIDIGRTRRPKAITSVDSIPMCEKWRGQVLKEISRKVSRIQELSLSDYQIRDLNDEINKLMKEKWTWEMQIRNLGGPNYMRGSGRVFDDDGREIPGGGKGYRYFGRARELPGVKEMFEAAARRGRPAEEDDEEGMKGRGGEIATKKVDANYFGYGLDEEDGTLLAYEKQKEKEAVERLRRKGDDAEDGWEPLPGDAGDGVEWRLPSLDEVQEELVDRRRRRLLDKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFX8</accession>
    <name>A0A317XFX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Spindle pole body interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_506908</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472471.1">
        <property type="nucleotide sequence ID" value="XM_025609591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFX8"/>
    <dbReference type="STRING" id="1450535.A0A317XFX8"/>
    <dbReference type="GeneID" id="37111734"/>
    <dbReference type="OrthoDB" id="66409at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052809">
        <property type="entry name" value="Actin_polarity_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012860">
        <property type="entry name" value="Afi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28245:SF1">
        <property type="entry name" value="ARF3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07792">
        <property type="entry name" value="Afi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08616">
        <property type="entry name" value="SPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="84"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="789" mass="87587" checksum="2D20826C4981C72D" modified="2018-10-10" version="1">MSISLPYRPPDDTALSLAATTSPSKSNGLPRLSPSPSIIHRRTPSSSGNSARRRSLGNGAAAMYPKPRRCKSQYPRDSSERHVEYILVASFHIDRGPIMEHQYPAAISGDESMLAELMLPDQTHVRSQDWTIFFLHKDTNADADDDDDTSSTGKKKKKKKKPRATDVESGDGDSEDAGGSTEEESSDEEEGGEGPPLMYVLNLVNTKQDNTVKRGAVVKAMAICTRHSFLHIYKPLLLLALEDYFKNPYPETLASLYNAVNSMDLSLLPRLSLLERLILQASNSKDMFIEKFEQMIHQRQVEEGGPFDDECPPSPRRPAPPRHTLPRDTHEFESKIVYNDIPIPVKVPTVIWPEIVGDFSLIKLIQVFAGPHAASPQPFPIHSHLTTSGPFTHPIIVLINAMLTQKRVIFLGHNRPSGEVAEAVLAACALASGGILRGFTRHAFPYTDLTKIDDLLRVPGFIAGVTNPTFANHPEWWDVLCDLPTGRMKISSHIEPAPVTEGLLYFQQQTAMNHHPPANANADPSGDNVFMEEVQRSITNRYGENAIRAKCRAYITKFARVAAAFEETVYGASNLYVIGPNEELSPESPSGLQADPLDPTTLRGHGYVWPDEGAKQRELMASVSRIEGWRTTRSYYSFIQDIAAMYYPSRPIQKPDLAHHHDRLRALRLPPADAGAIYIAFAHAVKDYAGICQLLTVTPENQAGLFYLSMGLFHPHQPVREATVELLERIAAHPAGRHFWAQLNRFAKLAFFRIKRERDAQSPASGMATESFGPQSLVGVAMGDTFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGE6</accession>
    <name>A0A317XGE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quinate utilization oxidoreductase QutH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_562535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472711.1">
        <property type="nucleotide sequence ID" value="XM_025614294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGE6"/>
    <dbReference type="STRING" id="1450535.A0A317XGE6"/>
    <dbReference type="GeneID" id="37116437"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF1">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="136"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="365" mass="39500" checksum="76D9673D0784B74C" modified="2018-10-10" version="1">MPLNIIIIGYGLIGPRHAKSVLQHPSTTLLALIDPSPTALTTASSLQTLSFPSLSALLSTPNIPHPDAAIICTPNHTHVPIALACLNANIHILLEKPISDGISTAVPLLRAVQGYPELKVLIGHHRRFNPYVVKMKEVVEEGLLGRVIAVTGMWTICKPDGYFAAPSEWRKEGGRGGVLGINFIHDVDLLHFLFGPVGRVYAERTIPQRSLDDPSHTAEEGAAITLRFVSGVVGTFVVCDATPAPWSFEVGTGENPLIPRVGSEDGHGFGGGFYRVVGTRGALSVPDLKRWSYDGGERGWGRKGVPFDLQLGHFVDLIEGREERVRCDVVEGLRALVVVDAVKRALEGECVVDVEDVRDVLEKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGY3</accession>
    <name>A0A317XGY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_5226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473051.1">
        <property type="nucleotide sequence ID" value="XM_025610190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGY3"/>
    <dbReference type="GeneID" id="37112333"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016292422" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8245" checksum="79159E7156ED8001" modified="2018-10-10" version="1">MPSWFCLSHLFASVSSSDSSHALRVSGDGSITGLSYTFTSLSCIDAINTPVADRTYGHQYSGAYLIFAFLLFAPDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UQR8</accession>
    <name>A0A317UQR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_591527</name>
        <name evidence="2" type="ORF">BO94DRAFT_591560</name>
        <name evidence="1" type="ORF">BO94DRAFT_591571</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000112">
        <property type="protein sequence ID" value="PWY63699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFK01000106">
        <property type="protein sequence ID" value="PWY63863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFK01000078">
        <property type="protein sequence ID" value="PWY64508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461303.1">
        <property type="nucleotide sequence ID" value="XM_025616116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UQR8"/>
    <dbReference type="GeneID" id="37118259"/>
    <dbReference type="OrthoDB" id="4510178at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY63699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY63863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY64508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="112" mass="11639" checksum="71E396620EDAD4B5" modified="2018-10-10" version="1">MHLSRLATALREKPLGAGWRIAMSPRAGMNPLQTTEVTKRVVAGRLEGASGWGTGAEPGSLLLLFTNTTRQFADIHGGGSVTAVPRVSSSLPLLLPGLPFHAATEGRGQLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317USZ7</accession>
    <name>A0A317USZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_357160</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000068">
        <property type="protein sequence ID" value="PWY64735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461320.1">
        <property type="nucleotide sequence ID" value="XM_025607143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317USZ7"/>
    <dbReference type="STRING" id="1450535.A0A317USZ7"/>
    <dbReference type="GeneID" id="37109286"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="9"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="364"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY64735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="597" mass="66644" checksum="6E0DE9AE6FF4A970" modified="2018-10-10" version="1">MEDDMSGHYQMLEELGSGSFGTVYKAIEKTTGEIVAVKHIDLESSEDDIQEIQQEISVLATCASPFVTQYKASFLRGHKLWIVMEYLGGGSCLDLLKPGVFNEAHVAIICQQLLLGLDYLHSEGKIHRDIKAANVLLSHAGKVKLADFGVAAQLINIKSQRNTFVGTPFWMAPEVIQQAGYDYKADIWSLGITAIEMINGEPPHASTHPMKVLFLIPKEPAPHLHGDEYSNTFKDFIAQCLTKDPERRPSAKDLLRHKFIRNAGKTEALQELIHRKQDWNAGRGVTRKIKYYAESLNTIRNLDDDDGWVFDTVKAPTMAIREEQDDLENEPEAEDWVFDETSEMMDDLHVSSPPMPPKHAVNTAVRRTPAPEHSPSLRRAKRRSSGVKQPLGVDMSFGNSPSTVRQFRRVSDKLPGDASYPSPYSFGMDENSSPKTLFSEPNSKEAQLGRRAYSKAVGLACQEVLGTTGDDEKREAISRLAEAWSDLEMIDPEGLYHIVKSMTERLQGDPKLAGLVPPAPPADSPQRPRLVLAQNNPHLKSHRRRQSAAVAEPNNLQPAQLANLPGQQVPGMEHTKQLSDVLYQRWSEGLRNRWPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UV80</accession>
    <name>A0A317UV80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_337350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000055">
        <property type="protein sequence ID" value="PWY65953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461532.1">
        <property type="nucleotide sequence ID" value="XM_025607011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UV80"/>
    <dbReference type="STRING" id="1450535.A0A317UV80"/>
    <dbReference type="GeneID" id="37109154"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000014">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="174"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="319"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="465"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="623"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="819"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="977"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY65953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1110" mass="124159" checksum="99EB7F7BFCCC1696" modified="2018-10-10" version="1">MSTHTAKRRRLSPSPDNSSRTQISHGNGQDDKDVFKNSRKTNSSTPRIIERGNNDRSAELALASGFYKSSLFKLQLDELLNELRPNYDKQVSRLQETLQKLKTVIESLPERPPRSALEAEKELRGAHGITVPFPEPRPGKETKYTVSYSRPTNINVVGSVSLRTGAKSANPLTVDLVVTMPNTLFQEKDYVNYRYFHKRAYYIARLAAGINGAEGLNFNVKFGLQDGDSLRPVILLEPKGTDKKETAPAKFQIRIITAIEDTLFPISRTLPARNNIRQGSTDTPASEESTPFYNASLRSEATVALYHKYLYNAARNCESFRDACVLGRTWLRQRGLGSSLYCGGFGGFEWTVLMSLLFEGGGPNGKPVLLKSYSSYQLFKATLQFLAGRDLTNPLLFSATDVLFNGGVPVLYDGKRGLNVLYKVAHWSYAFLRREANITVKMLNESRDDNFDKVFIVKVNESLLKFDRIVKLPSPDSANILQTIHNQAAIYDVLAKALGDRADLIHIYRGSAEPWPVEAKPSRKPENKGVFVGLLLNTENAARAVDHGPSAEQKEAAVSFRSFWGEKAELRRFKDGSIRESLVWTDEESSPSIVYQILAYILRRHFNYTEDDVDFIGDEYDQKLRDGGDDVFSYSSPSFSLITDAFNSVQKSIQDMDGVPLTVKQLAPASPSLRYTALRLQGSTKLPCNPADIVLQFESSARWPDDLKAIQMTKVAFLVKIGDCLKSSGVASICRVGLENESSGILNNAFLDITHTSGIVFRLRIHHDREQLLLERQLKDKGASPLAKQQVAYALSAYKRLFIQTPRLTQAIRTLCTRFPLLSPTIRLAKHWFNCHLLAGHVNQELIELLVVRVFTQPYPWDPPSSVMAGFLRTLHLLSRWDWQQEALMVDFGELDKSAMEAIQTRFSAWRSIDPAMNTVALFVASDIDLDGVTWTQHEMPPKVVAARMCTLATAAMKLLREKGHDLAISDLFHTSLAPYDFIINLRPELLHERSALSARFKNLDGRRTAQAAKPAIVKSFARDLQACYSPNMLLFHGDEGCSVIAGIWNPQILIPKSWTLKLAYSTCPAASKAADEVTMNCQAVLSEISRLSADLVDSIEVHTRVASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZC3</accession>
    <name>A0A317UZC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_540869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000059">
        <property type="protein sequence ID" value="PWY65290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461415.1">
        <property type="nucleotide sequence ID" value="XM_025613008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZC3"/>
    <dbReference type="STRING" id="1450535.A0A317UZC3"/>
    <dbReference type="GeneID" id="37115151"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY65290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="112" mass="13435" checksum="29783731A89A805C" modified="2018-10-10" version="1">MSSAPSVSAPVKGMRKNGKNWHDSKKPFRPTAGMTSYAKRLETRKHQEAVKEHEKELKEEKEAERKAHIQRIKDRRAAKEEKERYEKMAEKMHRKRVERLKRREKRNKLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0R3</accession>
    <name>A0A317V0R3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ribosomal protein S4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_579548</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461903.1">
        <property type="nucleotide sequence ID" value="XM_025615277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0R3"/>
    <dbReference type="STRING" id="1450535.A0A317V0R3"/>
    <dbReference type="GeneID" id="37117420"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="6"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY67259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="192" mass="22104" checksum="2495CBDCFC8B1B62" modified="2018-10-10" version="1">MAPAPRVYSKTYKVPRRPFESARLDSELKVVGEYGLRNKREVWRVQLTLSKIRRAARELLTLDEKDPKRLFEGNALIRRLVRIGVLDESRMKLDYVLALRVEDFLERRLQTCVYKLGLAKSIHHARVLIKQRHIRVGKQIVNVPSYMVRLDSQKHIDFALTSPYGGGRPGRVQRKKAAAAAGGDEEAEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V1T8</accession>
    <name>A0A317V1T8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_306916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461958.1">
        <property type="nucleotide sequence ID" value="XM_025606794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V1T8"/>
    <dbReference type="GeneID" id="37108937"/>
    <dbReference type="OrthoDB" id="5418574at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY67609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="172" mass="19551" checksum="6B2735472C4A55F8" modified="2018-10-10" version="1">MSLITDDLLLKLWEKAQEQSSDARASAKLWNHLWGKHFFSETNWVLSQKTVENGDRQRVDITIERMGEDGNLTVVVFHEANALEAVPKEVQKAEGRVYDACMRYLGENPGLQFAYAFTSSGSKGKAWRCVRGGDRLLLLFEDHSQYVEVHSQEGEIIKRAAQEMRLPIATLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2D0</accession>
    <name>A0A317V2D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_579703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461624.1">
        <property type="nucleotide sequence ID" value="XM_025615288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2D0"/>
    <dbReference type="STRING" id="1450535.A0A317V2D0"/>
    <dbReference type="GeneID" id="37117431"/>
    <dbReference type="OrthoDB" id="5393606at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF157">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="46"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY66360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="375" mass="41028" checksum="FDD81401DACECD0A" modified="2018-10-10" version="1">MIVTIEHHLGLSDNVHQRAIHFLRSPSAVLAAAIALPCVGTFSVCVRLALRWKMERSIGVDDWLILAALVFVIGMGAVQIYGVVEDALGYPTPPFASEEAELTELSSAQRIVELVDWITWVLMTPANGLIKLSSLFLYRRIFAVGHERVFGMVSWALIGLCALWTLAFFFATIFGCGRHLAYPWGPLGEIGSCNTNARLEAMMITDLITDVLVWVLPVPMVWRTQMKFERKVAATSVLLLATISLAAAVVRLIVQGQISNGGYAAHTDVDQTLTILLYWSMIESGLALIASCLPTMRLQTAWKKACSAFVQRPEMTLPSSHDMTPAEGSGRKGRMSISLGSTLVQQKSHSSQFVPLIEVGRFKGHGSDEEAGRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V630</accession>
    <name>A0A317V630_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxylesterase, type B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_628840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461969.1">
        <property type="nucleotide sequence ID" value="XM_025617512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V630"/>
    <dbReference type="STRING" id="1450535.A0A317V630"/>
    <dbReference type="GeneID" id="37119655"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016423317" evidence="1">
        <location>
            <begin position="20"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="43"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY67620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="526" mass="58171" checksum="9808022AFDE9CB28" modified="2018-10-10" version="1">MKLLWGLGSLFSCTTIALAKVDPPYYANLTWQPARSLSNWSNLTVETQTGTFIGMLNDTYPNVRQFLRIPYAKPPVGDLRWLPPQRPEKSRRKYDSTRYGPACPQYVSGESSMWNEYAPPNLLVSLGEDLNQGAVAWSSSEDCLSLAVWTPSYASHTSKLPVALFVTGGGGITGGIEIPSQLPSPWVSRSQEHIVVTINYRANIFGNPKSRALNDTSLTLLDVRAAAEWVHENIEAFGGDSQNIMLWGQSQGAALTHLYTLAFPDDPLAVKFGVISQPPSVTIDLSTTDDVYQDFDIVAKALGCNYGDDADAELECMRQVSWVQIEEYINRYSGSPSIAFSNYIPDEKYIFANESQRYAEGKVARGPAIRSDAAREMASDNTTSVMIAEGEWDCRAAQDSVLRRSLGLDTYRYFWGGNFSNISPVDWLGAFHWSDLLLIFGTYREDVGEVSQLEVKTSEAMQDHLLAFLKDPSTVNVTVGWPAFDADSPGGGKILEFGKETPVRMVTGDWLDGGCYNSSIPFRIWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V646</accession>
    <name>A0A317V646_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">C-4 methylsterol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_628375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462502.1">
        <property type="nucleotide sequence ID" value="XM_025617479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V646"/>
    <dbReference type="STRING" id="1450535.A0A317V646"/>
    <dbReference type="GeneID" id="37119622"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="5">
        <location>
            <begin position="90"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY69804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="249" mass="29347" checksum="9286D8519894338B" modified="2018-10-10" version="1">MSFMMHEIVYFGRSLPWIFIDSLGLFKTYKIQSSKVPSVREQWDCAKFVLLSHFTVELPQIWLFHPMAQFFGLSTSVPFPSLWTMAYQIAIFFVLEDTWHYFSHRALHWGPLYKAIHKIHHQYSAPFGMAAEYASPIEVMILGFGTVGCPILWCAVTGDLHIFTMYIWIVLRLFQAIDAHSGYEFPWSLHHFLPFWAGADHHDLHHEKFVGNYSSSFRWWDYVLDTEYSPEAIKRRRENKAVRGMKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V844</accession>
    <name>A0A317V844_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_502868</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462362.1">
        <property type="nucleotide sequence ID" value="XM_025609461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V844"/>
    <dbReference type="STRING" id="1450535.A0A317V844"/>
    <dbReference type="GeneID" id="37111604"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="15"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY69157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="336" mass="36254" checksum="6AF2A9AEC34E8BD8" modified="2018-10-10" version="1">MPSMMKAIGVEGGKGSADALFVDQIPTPRPGAGQALVKIKAFGLNRMDLLQREGKYPLPPQAPSTMGVEFSGVIAEIGTNTWNGLRTGDSVFGLAYGGAYAEYIVVSTNMLIHKPSELTWEEAAGIPETWITASQALYLIGEYTAGKSVLWHAGASSVSIAGVQLAKVDNASAVYVTAGSQEKIEFCVGELGATAGYNYRSQDWASEILKATNGRGVDIIVDFVGAAHFQGNLDVAAQDAHIVQLGQMSGSILPANSDISGILRKRLRFEGSTLRSRDEEYQGRLRDLLVDHALPKFIDRTFKVFIEKVFPFEEIADAHRLLESNKTKGKIICTIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V924</accession>
    <name>A0A317V924_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_478338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462223.1">
        <property type="nucleotide sequence ID" value="XM_025608684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V924"/>
    <dbReference type="STRING" id="1450535.A0A317V924"/>
    <dbReference type="GeneID" id="37110827"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052926">
        <property type="entry name" value="Metallo-beta-lactamase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13754:SF13">
        <property type="entry name" value="METALLO-BETA-LACTAMASE SUPERFAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G07630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="71"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="341" mass="37412" checksum="86F0DFE1F6B742F8" modified="2018-10-10" version="1">MSPLTEIDSLTATIIIDNDLDPMSPIPPDTVEVTGLMRTLATCSPHEVHDRGDVHKELRMEDICCAAHGLSILVTATKDGKQHTILFDAGPEGQAWERNAKRLGLGLADVERVMLSHWHRDHSGGLTRAIEMITAAKTATGCSDNSTIVDLHPDRPEYRGMAIGSEIISLQADPTVQEIERAGGEVTMEKDGHTVLDDFFYISGEIPRRTSYETGLKGGIRFDKDEADWFSDERIADERFLMCNLRGKGIVMFTACSHAGVVNCARHAVELLDVPLHAIVGGFHLATSEVSQMESTVRDLKKLDPAVVLPGHCTGWRAKFAIERQMPGAMVPCSVGMRIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V943</accession>
    <name>A0A317V943_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_609313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462787.1">
        <property type="nucleotide sequence ID" value="XM_025616578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V943"/>
    <dbReference type="GeneID" id="37118721"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY70893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="190" mass="21413" checksum="3D7B8BDC09DCA1E5" modified="2018-10-10" version="1">MSLLLACRRSPWNNRVPIRQQSPSPYHQRRMRRLVDLGVSVKHTRDEDVVGDSDQIPIEDELAMTFKPQEPHYLQRNWKCFDAAILVVGVNVSPRLIPSVEERSRIAGNSRFARQGSPALVEESRPQCHQIPIPLGNWRAARDAGCLHPSSPLLPARGSSTSPHGVSAEHRKTTTRARIQFLKSRHIATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V993</accession>
    <name>A0A317V993_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462233.1">
        <property type="nucleotide sequence ID" value="XM_025612873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V993"/>
    <dbReference type="GeneID" id="37115016"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="615" mass="69829" checksum="EEBA9FAE70E42DD2" modified="2018-10-10" version="1">MAARSALARFPLAKSIAKCFPGHLKRRNTRKPDIVSEELCDHTLQRLSPFLLRNRPLDILDLWPGAGLWSSKLNRLLQPRNHVLLEPELELFRPLLDPLAQSHPSYKLLSMDIFPINDWKTVLTEHFPEQGPDNCSHTGVLPQNDTLLVLANMPSTTSDKDHFTAGRWLQMFMETCMQQTGLHSYGSVRLLATLPSNEAQAVLPRYVVDRRRVALWTENVALHAFEVAAPPDEKFWVNHKGFNVATKNAARVAERTAEMNISTPPGREVAPLLPAPESPDPGRKPVPYTPRIRTALHDRFWDDIQALEKIPRSSPEYADAKKKRNRAQTRLNRDNRQSYFLQQMVDQSREIDAQYDALSRAAADPNTDSSELEPILDKITALRTAITDETQENYHDHLRQFPHIYDSYRASLRGYGNFDDALLAWDRRPFEPLQIQPGEFYPQGIDRTIIYFEANPNSPAIQKIHTLAPSERSDAMRLFENLTLSLGRGREALSAAEVFQLIFPGRCTNDIVKSIPSLAEYATKTPKPDFDTLPKTVHGEGDAPDPTISFQENLDYDLSDVRVHILSTSTIWDICIEYQRSGVPLSSVQLNRVFGGTLTSYKMGVHREPGKKRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9X4</accession>
    <name>A0A317V9X4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_550506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462889.1">
        <property type="nucleotide sequence ID" value="XM_025613496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9X4"/>
    <dbReference type="STRING" id="1450535.A0A317V9X4"/>
    <dbReference type="GeneID" id="37115639"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY71134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="313" mass="34860" checksum="BB0EED21070831DD" modified="2018-10-10" version="1">MTTWSPTQYLKFASERNTPAQDLLTHIPIQSPTRIVDLGCGPGNSTALLAARYNTPSTTSITGIDSSPDMINKANTTTTADNISFAVGAVESYTPDAPVDLYFSNAVLQWLPKGERLQVIKKLVKGQKAGGVFAFQMPDTLGEPSHVIMREVAERGPWAEKLRGVGREEVESLEEIYDVLVDGTDGVEVDVKVWRTVYYHALDGHGEIVEWVRGTGLRPYLERLGEEEQRGFLEVYEGELRERGVERSGCWDWIVYVKLGLWSMRVESSYSEKNMVMNILQGCRDAGMQNSGSSEISKYRDISPSSLGLFTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBQ0</accession>
    <name>A0A317VBQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_560483</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462703.1">
        <property type="nucleotide sequence ID" value="XM_025614156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBQ0"/>
    <dbReference type="STRING" id="1450535.A0A317VBQ0"/>
    <dbReference type="GeneID" id="37116299"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY70809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="230" mass="26192" checksum="3D964C530AF8E042" modified="2018-10-10" version="1">MSLQVPIRRLDEDWTGITDPALRKKLQNKLNQRALRPRQSPPTTLQDAVAMMTRFSAAARERYYAADPCLDQLFTLSKFNVLRAFVDNMASLGLSIEAMGDDVISPFSTDMPSNHNKEIVPASLFPTTTQCSIPHHPWLDCFPVPRMRDNLVKAAESFNDCELCTDIMDPTNGDIGIMVWGDPWLPQNWEVSQLFVQKWSWVIRGCPEVLVHSNYWRARRGLKKLTVSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFP7</accession>
    <name>A0A317VFP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_627988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463044.1">
        <property type="nucleotide sequence ID" value="XM_025617453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFP7"/>
    <dbReference type="STRING" id="1450535.A0A317VFP7"/>
    <dbReference type="GeneID" id="37119596"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000193">
        <property type="entry name" value="Ab-hydrolase associated lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="217"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY71808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="760" mass="84401" checksum="11B18C12A380BCBD" modified="2018-10-10" version="1">MFISDCDPDEGLSSSVARGPDPRVFDKPPYFDTTIQVGSIGQPPAIDSGGLSLQKGYELQDLGPVGEDQGNASTVTEPLLREEGPVSWNNQQGTSTDAAHPLFPPLPSYGPPSLISSVQCIIIRCVSFVLSLVFLSTVILGALVHTASASVSQLRHKIGGQASPTPRKFDAEERSRRVERNQAFRRWSYRQEKEVDEEGLDECPPLEGGKDPIVCDVAYYARRVGLDVETFKVQTEDGFVLTLWHVYNPQEYTPLPPKARRPRGPHVFTGQKSPETFRFPRKYPVLLMHGLLQSAGAFCANDDDSLAFFLCKSGYDVWLGNNRCGMVPEHTMLSQSDPRMWTWNIQQMGVLDLPALVSRVLFETGFEKLGLVCHSQGSAETFIALAKDQRPELGEWISVFCALAPAVYAGPLVERVYFRFMRIIPPIVFRAFFGIHAFIPFMMTVHRRLHPRIYGTLGYYVFSFLFGWKDARWDRGLRDRMFQFAPVYVSAEAMRWWLGGECFASQKCILATREVTLAEAEEDHRVERGHESALRSDTAWYGPQAPPVALWIAGSDGLVDGQRLLHRLQNGREPHVQVVHAKVIEDYEHLDVLWAMDAIDQVGQEVRQVLWQTMPQEARTFNPDNDIPDLTGQVFLITGGTAGLGARTTLRLAQHHANKIYITGRNAPAADALIASIGNTSNTTTSITFLPCDFTSLASVHSAAQTFLSRESRLDVLICNAGVMATPPELTMDGTTGVFALSEDSDSYVVGVADASILWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGC7</accession>
    <name>A0A317VGC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_475954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463140.1">
        <property type="nucleotide sequence ID" value="XM_025608583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGC7"/>
    <dbReference type="GeneID" id="37110726"/>
    <dbReference type="OrthoDB" id="4312109at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="46222" checksum="F6596B2FB9C745C2" modified="2018-10-10" version="1">MLVNKRGISPRRDTALNIRADSDDEYTHLDQNANEDEAWPYIMEANYNKGDLHIQYSTDQGDFQNHLLPSEDGSGDDEQDGSWPSNFTDDDNYSQNLEDLPSSTPKQFQTHFRDTIKAGKLGAGLKDVGRAESLEPFLAYFDGKMDKRQITSTLFQVGQYLRDNRPNEAESYVQKALNLADKLGERPLIARCQYWQGRVKYAQGHYDEAHQWFSECQLWITEYPEANTMAHYMQVCKPELSEEQRRHICQETRKHGRRARTESTVSVTLATQNSKQSWEDSLHLLSAENIPKSVHRRKMATPKSHLDRLPRDTGGFMLSGRQKLFSFEIYPIGMASRYRSTKLFPEQPYEIIVPQYRWDDFIEHHKDKSVTMSYLEREQRRYQTKRQEKIYRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VH16</accession>
    <name>A0A317VH16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA-3'-phosphate cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_244913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463235.1">
        <property type="nucleotide sequence ID" value="XM_025606395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VH16"/>
    <dbReference type="STRING" id="1450535.A0A317VH16"/>
    <dbReference type="GeneID" id="37108538"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="207"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY72461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="405" mass="42367" checksum="9044551EAD23385C" modified="2018-10-10" version="1">MASTSQPPLRFTSHKNFVYRLVFATLTGRTIQISQIRPSSPTNPGLAPHEISFLRLLESITNGSQMEISYTGTILVYKPGLITGSAAGTAASTGGVVRHELPAGCNRGVSYYLLPLCLLAPFSKAPIKVLFTGPGVITSSTPTGDMSVDSVRTAILPLYNQFGIFNNIELRILRRSNPGPNGRGGGGEVQLVFGHQLRLPKTLHLMNAGRIKKVRGVAYAVGVSASNNARMIETARGILNPLVPDTYVFSDVSSAPLVPAPEKSNPSGKKKIGLGFGLSLVAESSTGCLFSADVASPPAGGEAPEDIGKQCAYQLLEAISKGGCVAPAAVPTMLGLMTMGSEDVGRIQVGRDVIADESTIQLARDLTKFGAPGWGLRDASGENENGDVIISVVGRGIGNVGRKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHN1</accession>
    <name>A0A317VHN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_589676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463302.1">
        <property type="nucleotide sequence ID" value="XM_025615962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHN1"/>
    <dbReference type="STRING" id="1450535.A0A317VHN1"/>
    <dbReference type="GeneID" id="37118105"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY72528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="178" mass="20377" checksum="168C9EB5D2B6DD00" modified="2018-10-10" version="1">MCGDNVEGPYYQFGSRGMYDIRHPYKQTGDFVWPNFIEDLEEILRLPVHVSRIYGNADYICNWVGGQAISLAVNYTHAVQFRTAAYRPMTVDGLEYGETQEYGNFSFTRVYQAGHEVPYYRPIAALQLFNRSTAPYSGGILQRVQPRFGPDIAPARPRGLHTRSHLCHYSLGLSEIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIB8</accession>
    <name>A0A317VIB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_607754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463464.1">
        <property type="nucleotide sequence ID" value="XM_025616546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIB8"/>
    <dbReference type="GeneID" id="37118689"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="2">
        <location>
            <begin position="65"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY73199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="243" mass="26505" checksum="FE5D27FE088AB5EA" modified="2018-10-10" version="1">MSSGPNPQPPKTSPPTGASSLAVSPHPNPHPHSPLYPTTTPLTPKTVGIAISAILCCFCQWPFKQLDQNQAGIIIQHGHIHEVENKNLYFINPLTEKFISVDLSVKTREISQKSFDTPTGSVRIAPVISFRVANPSRFLSLFAKVQDAEEFVTTLTLSFIGVYLAISSHGNEGAVEKLRRDLFFITCTKNPKDRARADGNPENGKEVIPPDEAPSSSSSAGSPSTSNHMDDYPRCLEENEIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIC8</accession>
    <name>A0A317VIC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-containing monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_475237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463474.1">
        <property type="nucleotide sequence ID" value="XM_025608553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIC8"/>
    <dbReference type="STRING" id="1450535.A0A317VIC8"/>
    <dbReference type="GeneID" id="37110696"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF24">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="618" mass="69136" checksum="DC68C8B6300A9F16" modified="2018-10-10" version="1">MSLAQNHYVIQLPKTPVTIGPLDARAIAQRWITDLEALTAGNYSRLASLFHDDSWWRDMLALVWDLRTIQGREKIQAFLAANQPGAGISALRLQHEGKYQPSMESPAEGLSWINSMFFFETRVGRGSGVLHLTQNDAGEWKGYSMYTSLQELKSFEEPLGARRVDDTIESMPGGLNQGNWIERRQRLIEFNDEEPTALIVGAGQAGLNMGARLQSLGVSHLIVDRNERIGDNWRKRYRTLVTHDPAEFTHMAYLPFPKNWPQYTPKDKLGDWFEAYASIMELNVWLKTSIKSADYDDAQKQWTVTVVRGDGERTLHPRHLIWCTGHSGEPLVPSFRGQSEFKGTVYHGSQHDDASRQNVTGKRVVVVGTGNSGHDIAQNFYENGAQVTMLQRRGTYVITVEKGVIMMHEGQHEENGPPTEEADLIHECLPYPVQFALSVHFTKRVALAEQDLLAGLERAGFALDFGIDGAGISRAYMTRGGGYYIDVGCSPLIASGKIQVKRSPDGISHFTESGLVLKDGSTLPADIVVLATGYDNMRTTVRKVLGDRVADRCRDVWDLDEEGEINAMWRPSGHPGFWYMGGNLALCRIYSKFLALQIKAIESRLVDADDQTQVQPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIV7</accession>
    <name>A0A317VIV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">UDP-glucose:glyco protein glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_538924</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463627.1">
        <property type="nucleotide sequence ID" value="XM_025612587.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VIV7"/>
    <dbReference type="GeneID" id="37114730"/>
    <dbReference type="OrthoDB" id="27683at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003980">
        <property type="term" value="F:UDP-glucose:glycoprotein glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06432">
        <property type="entry name" value="GT8_HUGT1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000065">
        <property type="entry name" value="UDP-glucose:glycoprotein glucosyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040497">
        <property type="entry name" value="Glyco_transf_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009448">
        <property type="entry name" value="UDP-g_GGtrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040693">
        <property type="entry name" value="UGGT_TRXL_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040694">
        <property type="entry name" value="UGGT_TRXL_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040692">
        <property type="entry name" value="UGGT_TRXL_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040525">
        <property type="entry name" value="UGGT_TRXL_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226">
        <property type="entry name" value="UDP-GLUCOSE GLYCOPROTEIN:GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11226:SF0">
        <property type="entry name" value="UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18404">
        <property type="entry name" value="Glyco_transf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18400">
        <property type="entry name" value="Thioredoxin_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18401">
        <property type="entry name" value="Thioredoxin_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18402">
        <property type="entry name" value="Thioredoxin_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18403">
        <property type="entry name" value="Thioredoxin_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06427">
        <property type="entry name" value="UDP-g_GGTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="10">
        <location>
            <begin position="7"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="11">
        <location>
            <begin position="143"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="UGGT thioredoxin-like" evidence="12">
        <location>
            <begin position="278"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose:glycoprotein glucosyltransferase thioredoxin-like" evidence="13">
        <location>
            <begin position="534"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Glucosyltransferase 24 catalytic" evidence="14">
        <location>
            <begin position="1054"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1323"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF18402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY73875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1362" mass="153684" checksum="34E34BE3D4A1928C" modified="2018-10-10" version="1">MAAQDAACPVWVHSEGKQYCSSAMERAQQDVSGSDDPRELPFDRVFGDPSLPPAILYADVASPMFKEFHQSLSALAKEGQMSYRVRYRPPQHWSSRPLFVSGYGLELALKRTDYIVIDDRAAEERGPDGVESKKPGDAEDDLNDLRPLSSSEVSRLGLNTASYVMDSDDPFDTLVKLSQDFPKYSARVAAHNISTELLQDIRSSRLRMLPPGLNALWINGVQIEPRQVDAFTLLDHLRRERKLIEKFRNLGLSAKEAVELLAHPSLGESLARDGPQRYNYRDDIEGGGVIMWLNDLEKDARYESWSSELAGFMQRTYPGQLPAVRRDANNIVYPVDLTNSEDADIVVKTIQVFVKNKIPVRFGLIPVTFSDGAIAQLKVAHYLQETFGLASFMNYLEVSASKNKLASPDKACFQAATKDRDARAEKQPLSLEEILKNDSSDVTVAKTTAYLNRLGMKHEASHAFVNGIPVTRNANWAQEMSSRISRDTQLIQQRIADGEVDEDTWLPELFLSQAFDRRNPAFIPEDPKEIRAVDLVKIADSHRDLFGQIPRIASDQDDALESAHVIVIGNFDDEPGYELLSAALESRKAHGGIEALFLHNPKPETPAMARSSAVYRSLNGGKGTDVTHILEAITSSDSPSDEEARNVAQFWEAQQSVVEEFGLAPGMRALVINGRVIGPIAEDTELTSEDFDQLLTYERHKRITPVAKAVKALEFGEKLSDPLAFAKLTSLTTLSTISDVPEGIFESTSDIRLFLYNRWNNLRSAITVSTSEDPAITIVASIDPTSEVAQRWLPILKVLSELASVRVRLVLNPREEIKELPTKRFYRYVLNSQPSFNDDGSVSRPTASFSGVPVEALLTLGMDVPSSWLVAPKDSIYDLDNIKLSSVKEGTDVDAIYALEHILIEGHSRDMTVKSPPKGVQLLLGTENNPHFSDTIVMANLGYFQFKAQPGLWNINLKPGRSEQIFTLDSVGGLGYNPQPGDENNEVALLSFQGRTLFPRVSRKKGYETEDVLETGPKPGSAMDYMSKGFNFASDILSSVGVNTKGTSGKQADINIFSVASGHLYERMLNIMMVSVMRNTKHSVKFWFIEQFLSPSFKSLLPHLAQEYKFSYEMVTYKWPHWLRAQQEKQREIWGYKILFLDVLFPLDLDKVIFVDADQIVRTDMYDLVSLDLEGAPYGFTPMCDSRHEMEGFRFWKQGYWKNFLRGQPYHISALYVVDLNRFRALAAGDRLRGQYQMLSADPESLSNLDQDLPNHMQHYIPIKSLPQEWLWCETWCSDESQSQARTIDLCNNPMTKEPKLDRARRQVPEWTEYDDEIAALSKRVALQQQQQQQQQEEEEERQRQSYPDDEEDEETWNKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJH3</accession>
    <name>A0A317VJH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_589166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463676.1">
        <property type="nucleotide sequence ID" value="XM_025615931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJH3"/>
    <dbReference type="GeneID" id="37118074"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="39"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY74483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="519" mass="55885" checksum="65976E4FC3D4A867" modified="2018-10-10" version="1">MAGEDGGPIRVRYGAPAPDEMEPPALAMTPLKLKLMAVGYDTLWLSLFLSALETTIVGTSLLRIGEDLNDTSNTEWVVVVYLLTYDAFLLVSTNLGDVFGLKLILLIANSIFMIASITCAVAQTLPQLIVFRAFQGMGGSGIYSVSFLLSSVYAIANLLGPILGGAITDHTTWRWVFWINVPGAAITIVILIFTVPQMQINMGGNILNALKRADIVGCTLSVIWFIPLFFALQEAGSLYPWDSAPIIATLVLRLVLLFMFALYETRLMRCSVYEPTFPVRYLVDGVVSTIMLSMFSSGVLFYVAIIEIPQRFQIVNGLSAERSGILLLPMTIVTPFSATAAGIIAGKKPRLCEYLTLGGTALALVNGSATYQSQHPSPQYGYQVILSLVLGLIMPSVFMILRMTISQAQLASAIGANNMVRTLGGCIGLAICSSVSRSELDAGLGTFLSEAQIKALSQSTASLSLLPGAEEQRVRSVYGGSFNEEIPGLDCLWWSWSARISWAYCGEMASGEGEAGIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLT8</accession>
    <name>A0A317VLT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phytanoyl-CoA dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_228515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463722.1">
        <property type="nucleotide sequence ID" value="XM_025606288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLT8"/>
    <dbReference type="STRING" id="1450535.A0A317VLT8"/>
    <dbReference type="GeneID" id="37108431"/>
    <dbReference type="OrthoDB" id="187894at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF8">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="405" mass="45408" checksum="A4684E4B5F6AA668" modified="2018-10-10" version="1">MGSNGHNSAMYNRLFHIDSIHVDDFKRVCSQTTNPGSYPLAATVEKNIPIYDATTFDPLNLETTPALQSEWHHILESGPGIFVLKGMYHPSRYADTLAATNTAFQHIIDKERQSLLGPKGDHFAASGKNDRIWNSFSKHAFVDSSSFIHYYSNPWLRTVSESWLGPAYRVTAQVNIVKPGGAAQESHRDYHLGFQELDRCAAFPRSIQLASQYLTLQGAVAHSDMPVESGPTRFLPFSQTYEPGYLAWRRDEFRAFFKEQYVALPLELGDGVFFNPAVFHAAGANGMDESTDFQRKANLLQIGCALGKTMEHIDAVPVVEKCWDEVREIYQRDGLSAELEAWVAAVADGYPFPSNLDRRPPAPSGMAPESEQEMVLRGLQEGWNREKIGEELRGLQREGRGHQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLV9</accession>
    <name>A0A317VLV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_474496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463742.1">
        <property type="nucleotide sequence ID" value="XM_025608515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLV9"/>
    <dbReference type="GeneID" id="37110658"/>
    <dbReference type="OrthoDB" id="4434800at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY74549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="202" mass="23409" checksum="D6A4B0A704C539D3" modified="2018-10-10" version="1">MPPAIPGRENTTRNITHQTYLISHVWFYIPPGTEDPHVRVWPQYHHGLWVQKSALGTGDLHHVIGSISDIEGMKYECKTYTQNIISEPTFCNQIIIGYLTPAVYDDLKETFSKCPRPTLQKFWNHSTGTTEPADMSSAPIEFYTERQLVNFRFPALTTGKEFVEEQLLRKAWELIVPFDVVDMNPSGLFPQDQWIPQEQWWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNZ0</accession>
    <name>A0A317VNZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_577875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464081.1">
        <property type="nucleotide sequence ID" value="XM_025615191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNZ0"/>
    <dbReference type="STRING" id="1450535.A0A317VNZ0"/>
    <dbReference type="GeneID" id="37117334"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF4">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="226"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="632"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY76084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="804" mass="87853" checksum="6871C3068A5CCA31" modified="2018-10-10" version="1">MSRFSLQGRTALVTGGARGCGLAFARGLAQAGADVAIFDVIAPEEGFHSIEKEYGVRTAYYKVDVSSPESLAAGFSSFQTDFSNALDICVPCAGINRHQTFLDFKFEDHHDLLKINVLGLFHTAQLAARQMIANQTQHGSIVLVASMASHIAVKSQLCSAYCGSKGAVRAMCPAIAKEMAEYPNNMEIPSSHIPISTSIHTQSKSYTMAPSATNEGLGFPTTIPTTTVVVVGAGPSGLMLASNLLRYGTPVILLDDRPSRTTTGKADGLQPKTIETLKQLRLADELLRNGAKVYDISFWDSTPTHPLRRSGRQLHYPDHLVGASDPYILLAHQGMLEDVLIGDIEARGGRVQRSSAFVGVKKIPSGEGKGDKLEVVYEDVSTRTEKIIHAGYLVGCDGARSKVRDFIPDAKLEGEMTNASWGVLDGVIDTDFPDLWSKVAVRSHTAGSILWIPRERGMTRLYVELSSTDGEKVDRAKATTEYVIARAREAMSPFRLEWKSIEWFGNYVVGQRVARNFSDPDNQIFIAGDAGHCHSALAAQGANTSMHDSFNLAWKLNLVSRGLAHPSLLSSYGDERRKIANDLISFDAEHVAAFEKGEAALARNFDENIRFISGVGAEYTPGLLTRGKVTGGGGVKPGSLMPPANVTRYIDANPVDVQLDVPMLGQFRVYLFTPDVSTGGEFLDGFCEGISTSLEKIGKKAETSYIDRPRGYAERDEYVQPGRYTIVSQLVTYGLVTKSTKKEFELGDLPEVLQRSRWTVYLDDVDEKGCTMKWMGEMEGGRWAWWLFDRMGMWGRLPGGGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VR84</accession>
    <name>A0A317VR84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein arginine N-methyltransferase PRMT1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_538351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464288.1">
        <property type="nucleotide sequence ID" value="XM_025612473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VR84"/>
    <dbReference type="STRING" id="1450535.A0A317VR84"/>
    <dbReference type="GeneID" id="37114616"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="71"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="173"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY76475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="352" mass="39963" checksum="9213C2201AC93861" modified="2018-10-10" version="1">MSGEGQQSAESAAMTSSSADRMVGMDHAEVRYFTRYDHHSIHEEMLKDDVRTRSYRDSIYQNRHIFKDKVVLDVGCGTGILSMFAAKAGAKHVMGVDMSSIIEKARQIVAANGLSDKITLLQGKMEEVVLPYPKVDIIISEWMGYFLLYESMLDTVLYARDRYLVPGGKIFPDKATMYLAAIEDGEYKDDKIGFWDNVYGFDYSPMKEIALTEPLVDTVEMKALVTDPCPIITLDLYTVTTADLVFKVPFTLPAKRSDFIHAVIAWFDIEFGACHKPITFSTGPHAKYTHWKQTVFYLRDVLTVEEEEVVSGVLENKPNDKNKRDLDITISYKFETTDQNRASEGSCFYRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VS79</accession>
    <name>A0A317VS79_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_588579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464431.1">
        <property type="nucleotide sequence ID" value="XM_025615890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VS79"/>
    <dbReference type="GeneID" id="37118033"/>
    <dbReference type="OrthoDB" id="4221626at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY77244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="312" mass="34741" checksum="1423DE99E5DA517B" modified="2018-10-10" version="1">MARLCLPGLPFRKAPLVDRFKTQRAFLSFPVAPVARFVFRRNYEVPSRSFLPVSIPRTGVRSFANMRIGSRLPVPVRTPTPLTVSPVPAATGAGRSLKGSLSRLEERRAARQARSRPWVSPKSQSQQKSPEGPLSMLHPSPPTHPSHSFCPGSHRPDVRSSKAQRAIRRIDEVLAKSALASAGAGGRKTKSLKSVRFGETTAVPVSRWIDRRENVFPAPLAAMGYLQGWKVTPLSKPDEDGETEKYTTYWGSDSYIMLTSSHSASQPCDRYGCAWNRLARIADMRPTWGPATVFMAYNQLREQIRQRGGYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTW2</accession>
    <name>A0A317VTW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_204682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464280.1">
        <property type="nucleotide sequence ID" value="XM_025606110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTW2"/>
    <dbReference type="GeneID" id="37108253"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="77" mass="9486" checksum="CCBF7DBC75A5CB95" modified="2018-10-10" version="1">MIPDGLRDYQKREFERFQYLVCFFFLYLFITTTLPYKVHTIIPLSSSFHFNSYFTHSILINPEKEYRMGFVHLFFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUD2</accession>
    <name>A0A317VUD2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_588776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464271.1">
        <property type="nucleotide sequence ID" value="XM_025615904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUD2"/>
    <dbReference type="STRING" id="1450535.A0A317VUD2"/>
    <dbReference type="GeneID" id="37118047"/>
    <dbReference type="OrthoDB" id="10676575at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="269" mass="27728" checksum="C5BFD004175BBD2B" modified="2018-10-10" version="1">MEGKSTLATVKATGSVEAIAPSSQTPTPTSHKPSPFIGVTVAETTSSSGIADASTTSAPTPVVVLVTPEGSTTLVGTSYLAPDPDTISTSTPTTTPESEETSTIHATSTSVKTVYVTIANKPTTTSTTTSFAQDSTSTINTPEPAPASTTQTEAAVTYTPTSTSIVTSTIIVKLTPTPTEQPSTSSTEADEETTTPTTAEPKTATISYSSTTETGDILRIVPVTPTGHGYITITETETKMETKTVTETETETKTVTEKTTETVTVSEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVY0</accession>
    <name>A0A317VVY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aldoxime dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_537680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464803.1">
        <property type="nucleotide sequence ID" value="XM_025612324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVY0"/>
    <dbReference type="STRING" id="1450535.A0A317VVY0"/>
    <dbReference type="GeneID" id="37114467"/>
    <dbReference type="OrthoDB" id="3465714at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025702">
        <property type="entry name" value="OXD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13816">
        <property type="entry name" value="Dehydratase_hem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY78494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37595" checksum="5506E038EADEB12B" modified="2018-10-10" version="1">MFLASLPPNTPFTLTIIGTQPHTPAALITTLNELLTTAQTDSLLTHTETLTQHSPTSNSTSTIHLTYWPTTSYQTWSTSPAVTTFFSTLPDTAGIYREALTIHPDRIQGASNHNTPSGCMHMGKIELHPNLSGYWGCYPDRIAEKNITCPFSTDHITTTTTNDPSPSSSPENTSKIIPGKKTLTTIPNNLCFVIEGQDHTAASETEKSYWTENFDSLAQEWVSQALDAGVKKGVLSSRACYNPSASSSSSSSSTTPQRNTYPLTLTRDIQLLYFLDLDHMENLGRTNVAHVKLRKSFMEAYGPGGVMFPGGLKLWVETAVLRDGDFEAEYVGCLEGTGLMGLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWD3</accession>
    <name>A0A317VWD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_604649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464514.1">
        <property type="nucleotide sequence ID" value="XM_025616464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWD3"/>
    <dbReference type="STRING" id="1450535.A0A317VWD3"/>
    <dbReference type="GeneID" id="37118607"/>
    <dbReference type="OrthoDB" id="2400485at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34213:SF2">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2 (NTF2) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY77327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="189" mass="21380" checksum="15344DCEED4FBEB6" modified="2018-10-10" version="1" fragment="single">PAPTQRTNEPHPSLPQNPDTNTIDYTPDPSHSLPISPSRHEIQQHIISLYCGSASEDDMRVYSEKAIYDDPFSYCDTRYKIAGQWYGIPKLFAKSETLATEVTASTEHELVWKQRQRYTCRGVRAAKMEDSLVSLRLEDVGEGDGGGEKVVYHKDMWSEKDYDHEGFGAWMKKVNGDKLTGITQPPDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWX3</accession>
    <name>A0A317VWX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.131</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 11</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glycolipid 2-alpha-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_538297</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464233.1">
        <property type="nucleotide sequence ID" value="XM_025612461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWX3"/>
    <dbReference type="STRING" id="1450535.A0A317VWX3"/>
    <dbReference type="GeneID" id="37114604"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000168">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Alg11), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="16">
        <location>
            <begin position="161"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY76420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="366" mass="40853" checksum="F6984EA28CF3616A" modified="2018-10-10" version="1">MYPYMTLLGQSLGSLIVAYDAFNLLVPDVFVDTMGYAFTLAFSKLLFPSVPTAAYVHYPTISTDMLQSLDDQTGLQGVNSGAGKGFKGQVKRKYWIAFAKLYGWVGGHVDVVMCNSSWTSAHIRTIWGPARQTNTYKDPTVIFPPTAVSELESTITVTPETENTRQPLILYIAQFRPEKNHPLLLRSFARFLQERRKRQGETSDPETEPKLVLIGSVRHASPDETHIYNLRLLAHELRIRDHTTFLCDASWPTVLDHLATASIGVNAMWNEHFGICVVEYQAAGLISVVHDSGGPREDIVIDLGDGATGFRASTEEEFAAAFEAALALPAEEKVAMRLRARKSALRFTEEEFSLKWIGEIEKLVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXE5</accession>
    <name>A0A317VXE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_183977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464523.1">
        <property type="nucleotide sequence ID" value="XM_025605994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXE5"/>
    <dbReference type="STRING" id="1450535.A0A317VXE5"/>
    <dbReference type="GeneID" id="37108137"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="90"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="249" mass="27739" checksum="73D9DFB743D5A25E" modified="2018-10-10" version="1">MSESSFQDIENWLDQLSGASEAPTPPLTLPRPLSTISGYRQKRRVSMASARDSSPSKRPRIADDRTITSEISLRSTTTTSRQSRIRAFDPFSADEIPKTAFSDSSTLSDVDLDELWSELKTICFDARQCDIYGKDENAWCLDVVQPILISSIKGCQLLQLISSQQIGPSILPRSKNALSKINKKADYTLSFTCRDTSVRYFYDRISLGGHGYQLSQTTDAFTKRVLLFSGMEVKSDEGSKKEALAELAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYU5</accession>
    <name>A0A317VYU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_537467</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465015.1">
        <property type="nucleotide sequence ID" value="XM_025612276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYU5"/>
    <dbReference type="STRING" id="1450535.A0A317VYU5"/>
    <dbReference type="GeneID" id="37114419"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="614"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="656"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="718"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="340"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="415"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="484"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="799"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="863"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="799"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="822"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="863"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="915"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY79443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="940" mass="105510" checksum="5972E45BD26D7B95" modified="2018-10-10" version="1">MAPKSKDTLAVTPPPKSSSRSPSRSPGPKNRKKAGAQSSSYKSDGVADNNIFHLPTSDYRTLALVTIVAAVVRLFRIYQPSSVVFDEVHFGGFATKYIKGRFFMDVHPPLAKLLITLAGWLAGFDGDFDFKDIGKDYLEPGVPYVAMRMLPAILGVLTIPLMFLTLKASGCRTLTAVLGAGVVIFENGLITQSRLILLDSPLVFFTALTALSFTCFTNQQELGPLHAFRGPWWFWLAATGLCLGATLSVKWVGLFTVAWVGSLTVLQLWVLLGDPKNVTPRLWFKHFFARVFCLIVIPLSFYCAMFGIHFLCLVNPGDGDGFMSSEFQATLNSKGMQDVPADVAFGSRVSIRHLNTQGGYLHSHNHMYPTGSKQQQITLYPHKDENNVFVLENQTQPLGPYGSVEGPLAWDNLTAEHIEDGAVIRLNHFITRRRIHSHDERPPVTDVDWQFEVSAYGYDGFPGDANDLFRVEIVKSLSEGEEAKKRLRTIQTKFRLVHVMTGCVLFSHKVKLPEWGFDQQEVTCARQATLPNSIWYIESNSHPMLAENAEKVNYRNPGFFGKFWELQKVMWITNAGLTESHAWDSRPPSWPTLLRGINFWGKDHRQVYLLGNPFIWWSSTVAIGVYILFKGLSVLRWQRSCGDYNNVNFKRFDYEVGTSVLGWAFHYFPFYLMARQLFLHHYFPALYFAIIALCQEFDFLANRIQSLGLPSRPVIGKILAGIFLAISIFTFTLYSPLIYGNPWTQEACNQVKLLDSWDFDCNTFYTSLDQYVTQIVDTHAAIPTTEASVPQAPPVVVEQPPQQQAPQQNQAILPQEPEEPAVTERARHSSKARVEYRDQDGNVLDEEFVAALKKEGKVQFETRHETKTRLENGHIVDMVDGQLAPPHPDVEGQNPETVGRQPPVPAEDRPASVVGQGSSHEQQSSPDPKPASEVNEATQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYU7</accession>
    <name>A0A317VYU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_187660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464649.1">
        <property type="nucleotide sequence ID" value="XM_025606021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYU7"/>
    <dbReference type="GeneID" id="37108164"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="77" mass="7916" checksum="334F976B00614310" modified="2018-10-10" version="1">MKPPHGASTSPSIPFFPPPSSSLPSPLLPLSSSPSPSPSPPSLSPPPPLSSYPHHRSMSPAPHTSCLPQPCQTFASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2N7</accession>
    <name>A0A317W2N7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_558164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465335.1">
        <property type="nucleotide sequence ID" value="XM_025613986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2N7"/>
    <dbReference type="STRING" id="1450535.A0A317W2N7"/>
    <dbReference type="GeneID" id="37116129"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="162"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY80733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="522" mass="59122" checksum="12FD74F6ECC0E419" modified="2018-10-10" version="1">MPQARLSTTSSSIGMPMEGIVVHPPSSNQLHSLTEILGHTRFRDLIDGISCLTQSRLHGKGPYFEHVHPLYPFLDRSAFENKAFDTQVEDHLSNAPFSALYFTVLALGCLYVEGGSFDPGKGTAWKLFQHALGLFPEILQPPETLVNVQGIFAMNFSCIQISKTLTTEAARMVQCLGYSAAYTPGEDEKACHRVFWVIYWQERVECFFCSRAPIIADYDIGCPVPETPAATIGDLDWLMTTARLGRLISRMYECLFSVSAVRANLSTRIAAMNTISAELEQWKESLPKHFQLSQPFRPSHFKKPYAVNMAIQLRLIYYSLSISICRLRIHVSPNERNQGINLQLMEAARTIIYLSRYIDHEPHVPTWTLGIVPISALFIIFEFIIHNPRHAETSLNLAYLDMAVGYFSRWEVESKGTLPFSYVSEFAHIARQFVQDVQNRQDVVARRPEQTTIPWTEEPSRDSLAGQIPLHNPMDVLENGINATDMEFDELFYPSDPLQPIMGTSNPSASDFSALFDFSYWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2U5</accession>
    <name>A0A317W2U5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_520762</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465415.1">
        <property type="nucleotide sequence ID" value="XM_025610127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2U5"/>
    <dbReference type="STRING" id="1450535.A0A317W2U5"/>
    <dbReference type="GeneID" id="37112270"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019825">
        <property type="entry name" value="Lectin_legB_Mn/Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00307">
        <property type="entry name" value="LECTIN_LEGUME_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY80813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="627" mass="70957" checksum="34C6F7B7EFF42824" modified="2018-10-10" version="1">MAPTRGYAERQPASHTPLRRQRLKITTACQACRLGKVKCDGDRPACSRCLRKRTTCTYSRSPVYAGQVQHEAAVDTHTPVPVSPPTSRAHSLDRQASVKPVGLEHLNETQEVGPDQGHVYTAHGQFAGDVAAAIDARTGMIPATTSNLVPFVDAPLFGELDLEPNPFTNGCALPPRQYADNLVNIYWQHIDPVEPVLCQERFFHSYEKAYSGSDSPQQANEDVRLSILYTVFALAVQRQESTPQQQRNEEGNGYFQHAWGLVRPETILWSPGSIELVQCLMLMNRYLHCTNNQQKTWITAGLAMRIAQNMCSDSDKELKERVWASCIGMDRCVSWSLGRTSAPLIPLPNRFDTKMLGFQPGSKHSEHLRLAFELHEIGNHIQLAETQTRNSLAARLGLPRLYQQDEYHTVAVQLDTCLNRWEQSLPIDLQLQTLRTLTDRKSRAEGYLLHLRLLHTRIYLHRPMLARHYTVKSHPAPVCTTPPSLSDRLLQDSATICIETARSITSLILETHDPNEPIGLLPWWYRIYYLHIAGTIFLAAMFGSDLFTTAVSQSWDQVMFALRAHEHLSTYVQQCVWTFESLSRRVLDADVPSQKGIAGSFFDDIFQEVGFDFDNYLFGGQDTFHTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4K4</accession>
    <name>A0A317W4K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_536805</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465582.1">
        <property type="nucleotide sequence ID" value="XM_025612115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4K4"/>
    <dbReference type="STRING" id="1450535.A0A317W4K4"/>
    <dbReference type="GeneID" id="37114258"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016190556" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="45"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY81514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="552" mass="61691" checksum="D27F986F6FD2DDB6" modified="2018-10-10" version="1">MRVILGFALASLYLSATIKAHSVYLPLVDLGYAIHRATGYNAAGDYYNFSNIRYASPPTGDNRFRIPLPPSTDRAVVQDGMGGRICPQASPIWQTAIARDFVDDYLKGIPFNKSTDVLDYPYHPEPRDPRETEDCLFLDILVPARIMLRASDPVRGPRVPVIVWFHGGGFTTGDKSQFPGASGLIQRSMGFGDGVVFVSINYRLGAFGWLSGPGLRESGNANAGLVDQRMALRWVQEYIHFFGGDANRVTVMGESAGAGSIMHHITAFRHEEALFQRAILQSPAFIPVPDFEQQDLAFHQFLDILNVSSLDQTRKLPSQTLVAANAYQVARYSVYGSNLYGPTVDGTVISALPGELILQTEYEWYMKIMLGRNANEGLRTTTPDAIHEDVYRRYLRQTFPQIQPGTIDYLLQQLYPPVFNGSRGYHDAVGRASSIMADYGYQCNNYYLNQVYKGETYAYLFDVSPGLHEDDVQYTFYDGDSSKQVNATVAYVLQDYITSFAMGGAPRSKIGPEFTPYGPNRTMMDLGGTGIKQIRDPTDRGRCDWWQLGFYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W792</accession>
    <name>A0A317W792_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_520577</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465823.1">
        <property type="nucleotide sequence ID" value="XM_025610116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W792"/>
    <dbReference type="STRING" id="1450535.A0A317W792"/>
    <dbReference type="GeneID" id="37112259"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Stress-response A/B barrel" evidence="9">
        <location>
            <begin position="3"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY81755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="849" mass="95719" checksum="5FA259D763E382F4" modified="2018-10-10" version="1">MTLVHIVLFKFRPEVTEEHKQRFVTELKKLKALPCVKSGRLLVGGPSVTDPIDRSKGFQIALVSYHENIAALTEYQASQEHHHVTSTYMFPYKEDLVRFDFEVDEEDEYMCEFPVLGSRGVSVRAEIPASIFSPSSNPFPTQRTPKQSRQSAPMILLVDITWQSPHKIVIQHPLSQCDGNEPSCSSCLKAGAHCVNDGRQEVPRRYISNMENRIRWLESIVKENCAHIDLGREGQIDPSEETVQNDIMDTSTQYHLGDLTAADSQQIIPGEPRFDEQRQSGIVENAPNALPEHQGLDQARAASNQHQQAHEIGLVSLSSGGGPRYIGPSSGYFFANRIFSSAGRRRKSRGAKRATADSAHLSAELLNSLTLLPARKESAIELSTKYFRTVHLTYPFLHEPTHMSVIDRVYASQEANPLDLFQVYMVLSIAALALSRECKVHLPVEGYYASAMKYVEHVCTDGSMTALQCVLLLMVYALHNPSSDVNIWNLNYQCLASVIDLGLQRDVRASSSLRISVFEQEMRTRVFWVVYTFDRAICTMMGRPIGIRDEACEMRFPLDIPDYNLVNPDISQHAPESRSHMANAIHLFKLAKVNSEIKYVMHSIQRDVPAYAYPPVRDIFAWQQDIVNYLHDWLSEIPQPTGNTEDTMSKVCKIKYHETMILLLRPSPAIPSPADEILDLCFHQAVDLLQGFGELYKVGSLLYSRLLVHSVFLGALVLLYCIWKLPRTTAKVRVDELVSNLTVAQNILSSIGEHWTEATRARDCIDELSSVTIQRLLNHHPGQSHAISEGNEGSNEIPMTLVASEENLQNVDSYQFNLFDDLLQGDFQSWSGMSDIDGLMWEIFNNSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8B1</accession>
    <name>A0A317W8B1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_537248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465239.1">
        <property type="nucleotide sequence ID" value="XM_025612226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8B1"/>
    <dbReference type="STRING" id="1450535.A0A317W8B1"/>
    <dbReference type="GeneID" id="37114369"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="285"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="443"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY80380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="583" mass="63701" checksum="2AF6E199F6A845C0" modified="2018-10-10" version="1">MTLFILTETSAGYALLKAKDKKLLKRDDLATEASTAEGVSNLLKLKSFQKFDSAATALEEVASLVEGKVTPRLASLLDEVKDEKKVSLAVSDPKLGNAIGKLPGLSIELVADSSTTDVYRAIREHLPTLIPGLLPQDMSTMSLGLSHSLARHKLKFSPDKIDTMIVQAIGLLDDLDKELNNYAMRVKEWYGWHFPELAKILNDNIAYARLVLKMGMRTNWETADLAEILPEEIEGSVKAAADRSMGTEISQEDLEHIQALAEQVVGFAEYRQQLAGYLTARMNAIAPNLTALVGDLVGARLIAHAGSLTNLSKSPASTIQILGAEKALFRALKTKHDTPKYGLIYHASLIGQATGKNKGKMARVLAAKASLGLRVDALAEWDDDATEEDKAALGTEARYNLERKLAAMEGKPLKPRGVAIGPGGAAQPSKFELNEARNYNADADAVTGDEPVSAKKSKSKKLVEEVQDEEMADADSDAEDDSDSDEETDKKHKSKKSKDSDLEKMAEKAGLSVKRYQRKLERGEIQFDAEGNPTSVSKKDIKKAKKESKKSAKGEEKKRKRSDDGEEVDNAEKKKKKKKKGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9T6</accession>
    <name>A0A317W9T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_148532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465806.1">
        <property type="nucleotide sequence ID" value="XM_025605785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9T6"/>
    <dbReference type="GeneID" id="37107928"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="33"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY81738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="543" mass="58273" checksum="8490D7450D0CC29B" modified="2018-10-10" version="1">MDSPLHPHSEKTHHGANTTDDVRTITGFRWFLICAALYLSALIYGLDTTIAADVQGAVIGTFSDVSQMAWIGAGFPLGSVAVILPYGFLYTTMNMKWLYIAGIVLFQAGSTLCGAAPTMSTLIVGRVIAGAGGTGIYLGGLNHFSAMTTRHERGTYLTGTGFVWGVGAILGPVVGGGFSDSSATWRWGFYLNLVIGAITAPVYLFYLPAIHPGAGQSLRNCLLHLDYIGFILSAGMWVTFTLVFISAGGIWTWDSGATIALIIIFAVLFILYALQQYFCIFTTASTRSFPGHLLRSRTQILLYITTTCANTAMFFTAFYIPIYFQFTRNDTSLMAAVRLLPYLLVTITTNLAIGFLLPKIKYYMPLCLISGVLLTLSSALFVSYLSPTTPAGQIYGFTILMAVGTGITMQLGYAVASLKVPAGDVFSAINLQNVAQIGSTVICLVIASQVFQSTAVQNLNSVLKGQGFSEIEIHNAVAGAQSTLFQSLSGELREKAIRSITDAMARAFIIPLVAGAVGVVSSLGMKRERLFEDEEREVICVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WAA1</accession>
    <name>A0A317WAA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_557808</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465924.1">
        <property type="nucleotide sequence ID" value="XM_025613959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WAA1"/>
    <dbReference type="STRING" id="1450535.A0A317WAA1"/>
    <dbReference type="GeneID" id="37116102"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="47"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY83139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="227" mass="25552" checksum="27983C36F4A80F5A" modified="2018-10-10" version="1">MATSTGTGWAQLRQQARSLETQTENLFHTYSQYASITKLPPTPSEEEQRIESQLQDLLERRDTLISQLSRLLDSEATLTSSALKQNNLSRHREVLHDHRRELQRLKSAISESRDRANLLSNVRSDIDAYRASNPAQAEADYMLEERGRIDESHNMMDGVLSQAYAINENFGLQRETLASINRKIVGAASSVPGMNALIGKIGSKRRRDALILGAFIGVCFLVLVWVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD10</accession>
    <name>A0A317WD10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_625381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466273.1">
        <property type="nucleotide sequence ID" value="XM_025617274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD10"/>
    <dbReference type="STRING" id="1450535.A0A317WD10"/>
    <dbReference type="GeneID" id="37119417"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27119" checksum="2B286319AC690BF1" modified="2018-10-10" version="1">MKTYNPSGITLDFEPSHVHFIEPLKSSETSEIFHISYDGQSYFLKVFHMDDDPGFSPDGRDLSRYRCESQAYLALSRHGTCDMGIVPQFYGVLENLDPSVFEPNLEAFNEDKVHPCAIILEYLHDASVFTSEPRSVELRQYAKDALNQIHQAGVIHNDPHPTRNLVVASGGRVVWVDFDTSIVFSGARRGELDFNEEACDELKYFESCARRFPVKGTPLQGNKMPMPQSHLSSSTVALIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD69</accession>
    <name>A0A317WD69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_468679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466169.1">
        <property type="nucleotide sequence ID" value="XM_025608271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD69"/>
    <dbReference type="STRING" id="1450535.A0A317WD69"/>
    <dbReference type="GeneID" id="37110414"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="670"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="675"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY83701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="765" mass="85827" checksum="B61BB0AD7E7A5CC2" modified="2018-10-10" version="1">MASALATPVDSSRSPAMATDSHRRSTSTDGSTPAKRLRRASDSPAKHPNAPRQKITRACDHCKEKKTRCTGTLPCVRCTRLALPCEYNAAYSRGLPPDPLPALSSMADNCDCAPPAKKATAADRDLGRRQSLSARQSPRAVASTRLQPQFRNEFSQRNSPDPAVTDLEGNYLGPASGVSFLNRVWRRLHQDEVHAIPDRPENEPSPKNTSVFMFGDKPYSDYREVVFTLPPFNIAQELVDIYFDFSMVTYRFLHQGSAEEWLRQVYANNISSANLPTGPLVVRTAIILMIFAVSTLYEEQRPSNQVDGWCRSEQWYAASKYMTSLESGPPRLETVQARLGQCLYLLSTSRANECWYSFGTALQLVTALGLHRKFPGKLPKGGNTYLERELRKRILWSAYMLDRYLSVMFGRPRLLHDEDIDQDLPDEVNDEDMLQDDPAQRTGSADCMMVASILHFKLGRILGDISRQLYTVNPSSRSPPLETAARLTSELEQWKSAAPPLFNSVRATSLIPPLCRQSQVLQLAYSHAVIHATRSFLLNDFSDLRRRPQVPHPVVSSHVRKCVQAAQEVMELVDGLAKQSVLIQSFWFTHYVCFCAITVVYIYTIQQHRASDLETSSPGSEDVDRLSSLFRLAETCQQHLAEATRKNCPSRRYSIILEELRKEVHRQIGPHSGCIDNSSQQVRARSSTNQEPAVEQQITPSHMYPQIPLDSPFNYSDGLQATDLQTFGPDGDIGLIDNLEGSVWWTQLDCWAFTNLPGDPSTLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHF5</accession>
    <name>A0A317WHF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Pectinesterase</fullName>
            <ecNumber evidence="5 13">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_624994</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="5 13"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466893.1">
        <property type="nucleotide sequence ID" value="XM_025617254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHF5"/>
    <dbReference type="STRING" id="1450535.A0A317WHF5"/>
    <dbReference type="GeneID" id="37119397"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018040">
        <property type="entry name" value="Pectinesterase_Tyr_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00800">
        <property type="entry name" value="PECTINESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="10 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016190885" description="Pectinesterase" evidence="13">
        <location>
            <begin position="18"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="14">
        <location>
            <begin position="28"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY85876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="331" mass="35499" checksum="CE2877C291D1A456" modified="2018-10-10" version="1">MVKSVLSSIIFATTALAASRMTAPSGAIVVAKSGGDYSTVSDAVAALSTTSTETQTIFIEEGSYDEQVYVPALKGKLIIYGQTEDTTTYTENLVNLTHAIALADVSDDDETATFRNYAAGSAVYNLNIANTCGQACHQALAVSAYGSEQGYYGCQMTGYQDTLLAQTGYQVYAGSLIQGAVDFIFGQHARAWFHDCDIRVVEGPTSASITANGRSSESDTSYYVIHKSTVAAADGNDVPSGTYYLGRPWSQYARVLFQKTSMTDVINSLGWTEWSTSEPNTENVTFQEYGNTGAGAKGTRASFSEKIDEPVSISTILGSDWEDWVDTSYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WI82</accession>
    <name>A0A317WI82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_599444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466388.1">
        <property type="nucleotide sequence ID" value="XM_025616325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WI82"/>
    <dbReference type="STRING" id="1450535.A0A317WI82"/>
    <dbReference type="GeneID" id="37118468"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY83920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="540" mass="58924" checksum="A5C53DCEFB6C36A8" modified="2018-10-10" version="1">MADGFPTQSQIELCSPRGNDFPGTSTETLLTRDALELARVGKKEVMKRRFRLASTVGFASSLMITWEAMMMSVINDSSGGPPGLIYGYIGVWIAFLSIFVSMGELASMIPSAGGQYHWTSILAPASSKRFLSHITGSITIIAWETVAVGNYVISASVLQGTVELGRPQYDPKGWHVTFITWGILLVSLLVVTYLGVVLPAIEIFILVIHIFGFFAVLFSLIALGPQSDAQSVFSMLVDLGNWHDITLSSFVGLQGTAVAFVGMDGAIHMAEEVENSSIVVPQSMLLAIVINGALGFAMLITILLKSGDIQALLDSDTKYPFMFVLENSTQSKTAAIILSSMLAILTACAGLSTLASGSRMLWSFSREKGVPGWNWIRQVHPRTTLPNHSIFIIVIATALISLINVGSNYILNITLSLIMQAFFASYMIPLSLLLYRRMQGHIADPKEANADSPDKPYIWGPFRVKGWLGIANNIFSIVCLVIMFLFGCWPLQNHPSPREVNYSIALTGGATVLAVVYYLGWARRVYRGPVVEVRVYASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMX5</accession>
    <name>A0A317WMX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_585299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467597.1">
        <property type="nucleotide sequence ID" value="XM_025615686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMX5"/>
    <dbReference type="GeneID" id="37117829"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="71" mass="7253" checksum="CAFECEF304DEF298" modified="2018-10-10" version="1">MSPGQSRSEVINARGVTVDVDVLPTVSGATTRKRVSAALDDDDLQVLARFFHASVAGTGSIGASQPPLTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNJ5</accession>
    <name>A0A317WNJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467218.1">
        <property type="nucleotide sequence ID" value="XM_025611859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNJ5"/>
    <dbReference type="STRING" id="1450535.A0A317WNJ5"/>
    <dbReference type="GeneID" id="37114002"/>
    <dbReference type="OrthoDB" id="4509994at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="154" mass="18004" checksum="B01E45F68AC64DBB" modified="2018-10-10" version="1">MARESGQTPAPASNRRLSAMVPGEPDWKDRFNQPEFDSRYKRDPKQTFDILLQIFNNLETERGNLLDVQDRQSQEIAIFTDPNKARNARRQYSGLRMRVGEKFYAFISNFRYLAVEAGISEDIWKEDLYNKIPPKRRRQLCTVSTTRSIPLTAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQ35</accession>
    <name>A0A317WQ35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_546280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467236.1">
        <property type="nucleotide sequence ID" value="XM_025613285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQ35"/>
    <dbReference type="STRING" id="1450535.A0A317WQ35"/>
    <dbReference type="GeneID" id="37115428"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF3">
        <property type="entry name" value="FUCOSE-SPECIFIC LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="28278" checksum="58C151A231F5C14E" modified="2018-10-10" version="1">MPPSSSSFTALNLPSTFSLPQCMEYFTLTAGPNTDLWRKPPNRDTATAPIVFTSLRSAFVVAEVTVTADWEMEWDQGGLVIFAGAAPQSFSSDSVPLTSGTRPGRHGYPQTARPCKWVKAGMEFSSGTMNASSVSATADGADWCLSPLSIPDRGPSAMHSLRIKLERIGHSLWIWYQVPSAVPYAMTPGAVSSTWKKLREVTWFFYGVEDKFVHVGVYASRPHSLPRSGTMWEMVNGRGMGGTASSGDGLVVEFEDLEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQW1</accession>
    <name>A0A317WQW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_74481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467516.1">
        <property type="nucleotide sequence ID" value="XM_025617641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQW1"/>
    <dbReference type="GeneID" id="37119784"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="174" mass="18605" checksum="0D1022271FBE1D4C" modified="2018-10-10" version="1">MEPAMQVIRPVSRRHAGSPALDLAPVKTSMLVGARLRSCIPVKVLDLLDRTVSLSQNCLRLSPPSLLASTIRLSQALSLCLGRQVSITSSSNIIRRQHHHHHHTPHHSTSTPHHTPSSSSSTITTTTTSQGHDEPLTDLLCHPLLVPCFLTKGGSKVEATAGGVQGPQGPLNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQW7</accession>
    <name>A0A317WQW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_574895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468266.1">
        <property type="nucleotide sequence ID" value="XM_025615050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQW7"/>
    <dbReference type="GeneID" id="37117193"/>
    <dbReference type="OrthoDB" id="4435532at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016340573" evidence="1">
        <location>
            <begin position="18"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="118" mass="13342" checksum="29D63A4E2CA10975" modified="2018-10-10" version="1">MNFLLLLFLGLLQLVSAARSGTYNAGWAVGDTTWKQTDSVFERETGIAKYRLFQADGWIYKYQLDIEVSQVQGPIGGTYVFYDSTGDEYNLMVFIAGFHTIDFNSDDPYIQMVKVVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT90</accession>
    <name>A0A317WT90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_534321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468460.1">
        <property type="nucleotide sequence ID" value="XM_025611517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT90"/>
    <dbReference type="GeneID" id="37113660"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY89549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="56" mass="6795" checksum="709417202130DB79" modified="2018-10-10" version="1">MRACFRFFSSPFGSFLFLLFVDSFGFLNRMHHLYCGSWRHWQVVGRKQLQPLYFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTD5</accession>
    <name>A0A317WTD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_594522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468575.1">
        <property type="nucleotide sequence ID" value="XM_025616202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTD5"/>
    <dbReference type="STRING" id="1450535.A0A317WTD5"/>
    <dbReference type="GeneID" id="37118345"/>
    <dbReference type="OrthoDB" id="4455582at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY89664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="363" mass="42932" checksum="8510B6F667E4D1B9" modified="2018-10-10" version="1">MVSAADESRVLSLSDLPVEIRVQILGHLECLEELENAIRSSEVFRVAYESCSHMVLTLMLENALHFDLFPLAILHWELSQTRWWNQDHSENWLNVRFDAMKTPNFIWTATMEQNLDMLRFLKHVQYFAQEFIDWALRRFHENFGGVETPASRSEYDRVMRGLYLQSIIIQATVSRGWDHSSTTTEETKQSAWKKFVSSFQPWEIEQLRCMAQWVSGIIPLPLICYSCVQGRWLEKDLPKEQGKELLTHHGLALLRGVESIDNRTDHYKIYIIRDFFEDLREYSEKLYRVVFDLLKDKPYIEAAEPRFKSDNPGPKQLWAWVRADPQFDVCRLKDKIGYPQYGSLIWDEERVKRSRLMKTSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WU31</accession>
    <name>A0A317WU31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_515781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468154.1">
        <property type="nucleotide sequence ID" value="XM_025609933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WU31"/>
    <dbReference type="STRING" id="1450535.A0A317WU31"/>
    <dbReference type="GeneID" id="37112076"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY88792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14781" checksum="458C8A0756725A1F" modified="2018-10-10" version="1">MVKTSVLNDALNAINNAEKSGRRQVMIRPSSKVIIKFLSVMQKHGYIGEFEEVDDHRSGKIVIQLNGRLNKTGVINPRYPVQLRDLEKWATQLLPSRQFGYVVLTTSAGIMDHEEARRKHVAGKLLGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVE9</accession>
    <name>A0A317WVE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_584348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468714.1">
        <property type="nucleotide sequence ID" value="XM_025615618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVE9"/>
    <dbReference type="GeneID" id="37117761"/>
    <dbReference type="OrthoDB" id="2841294at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016356980" evidence="1">
        <location>
            <begin position="18"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="139" mass="14724" checksum="4492E060EF77E49F" modified="2018-10-10" version="1">MRTILAIATTFVASALAQNVDIALPAAGQTVKAGQQLTVQIQRPTPPTNVEEMSIAIGLQSCASSTCYPASEVMGVVLYNGPFKPVYHEYYLPQYQNFTVTIPEGTAAGAATLGVAHATLIGALYEPYFQTLSQNITIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWE9</accession>
    <name>A0A317WWE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_38474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468418.1">
        <property type="nucleotide sequence ID" value="XM_025607283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWE9"/>
    <dbReference type="STRING" id="1450535.A0A317WWE9"/>
    <dbReference type="GeneID" id="37109426"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="272"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="570"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="657"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="764"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="941"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="765"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="988"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY89507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1006" mass="111440" checksum="F2D4C1327EE97700" modified="2018-10-10" version="1">MHKISNFTGQARHGWERMTPTFGMSRPHTDMASHSLRRPHGAPPMTPPTGIDPTVNLSFNVPFSSTLAGPDVDDVLHASPAALQRWTFPEGTPEGTPVHQLPVHVNNVEALRRLCRQITESSNGRVEAAVTSSEPKSVPSLQRRPQGLATNVCITGDGETVRKMRARVLNETPILLRCATVDVDMHLILDGSTKNIRQTVLDHLDTLAAYTGTDIFLLSPKIRDTDSAVVSSYGYASDNGLDQRFRLSIYGDMESAEHAKTRVLIMIDQILKRHVDAMKLEVTMHTLVCGRTRKNIKLIEAATGTALYFPPPFPRIFGYTPPGANRRSEDEVYITGDTQEQIARAKQKLRELVMGVKIYVKDVIVNSNKIDNILLDRLDKVRKVMELNGSYILFPQLGTQRGLVRIQGTEVLHVERTVREIMALAGQFYSASWWIIMPDPSQGGFRAPSPADVRTMLSDICSNSGAEVSFDNLTFTINGSDDAVKAAMMVINQIPFVQRSQYQMRVKIELANEHKEFVSGKKNGKINKIMGQSNVQIIFDGFNEYNFYIDVCGNQYESTKNGLDLVEQEMPASISFHVPDQYHKRIIGIGGQHIQRIMKKYSVFVKFSNAMDRGGMGKEDDDIKVDNVICRTPARNAQSLDLVKQEIMDMVEKVDAEYVSERVVINRLYHRELLARMTEIDELEKKWNCKIEFPSTELASDVVTISGPEYQVPQAVDALLGMVPESHELLFQSSAELREYFKSAEFHDDVCAKLKDQYEVDTTVDTSSDLPASSSDSGSSSPVFGPEDRAVLGYTRNNAGGLKDAIDFLISRLVAHGLDATTVKGAIPRPKSDSFEESLPFFDSKLLQHAPAPIVTDSPTRPSFSDETNERGSIFERLRKPGSISSFSSFIGRKNHSASPGSFFKHASSNASKASLVSMESRDSGYRNPWNDSGVNLAEDDVPVLGSSHSHSSSNGWPARFDTKFPFGTAPGDMTPKHDPRASFDSGRPSTSNSTSGYPAPIGPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWG1</accession>
    <name>A0A317WWG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_464392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468012.1">
        <property type="nucleotide sequence ID" value="XM_025608061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWG1"/>
    <dbReference type="STRING" id="1450535.A0A317WWG1"/>
    <dbReference type="GeneID" id="37110204"/>
    <dbReference type="OrthoDB" id="4158189at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY88650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="144" mass="15263" checksum="422221415FAAF029" modified="2018-10-10" version="1">MCGPSRPSSGNLIAVIFPYSSSSTSSASSLSSSSSSLDKTKALFRIASPQTLTLFRGSKGVNVRIEYYGDLTAPITSPPLYDFRVPFPGIQTGGKGEGNEEVEVILPERLELGVSERGIVGRLVRVSLFGDGEVDMGRGIVGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWU2</accession>
    <name>A0A317WWU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FMN-dependent alpha-hydroxy acid dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_623273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468883.1">
        <property type="nucleotide sequence ID" value="XM_025617138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWU2"/>
    <dbReference type="STRING" id="1450535.A0A317WWU2"/>
    <dbReference type="GeneID" id="37119281"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03332">
        <property type="entry name" value="LMO_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000132">
        <property type="entry name" value="FMN dependent dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037350">
        <property type="entry name" value="LMO_FMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF86">
        <property type="entry name" value="DEPENDENT DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="321"/>
            <end position="325"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="344"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY90505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="403" mass="43969" checksum="4B1469A54245AECB" modified="2018-10-10" version="1">MSGNYGDYQSEIYGRGAMTGILPSVTTDPRLLEEQAEKALGARSFNYVAGGAGEKATMDSNRLAFRQWKLIPRMLKQMNDQNISVTLFGQDYPTPLLMAPVGVQSIFHDDKETGLAEACGNMGIPYILSTASSSSIEEVAQANRDGKRWFQLYWPQDDEITLSLLKRAKDNGFSVLVVTLDTWSLAWRPADLDNGYVPFIQGVGNKLGFTDPVFRAKHEKASGSKVEEDIVSASRSWISQIFFGQPHVWEQISFLRKNWDGPLVLKGIQHVDDAKLALEAGCDGIVVSNHGGRQVDGAIGSLEVLPEIVDAVGDKLTVLFDSGVRTGVDVIKALCLGAKGVLVGRPVIYGLAIGGKHGAEAVMKGLLADLWQSMKLSGMRTVTECNREMIRKVVYPGDGKAMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WXJ0</accession>
    <name>A0A317WXJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_514548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468989.1">
        <property type="nucleotide sequence ID" value="XM_025609893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WXJ0"/>
    <dbReference type="STRING" id="1450535.A0A317WXJ0"/>
    <dbReference type="GeneID" id="37112036"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="57"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY90611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="521" mass="56272" checksum="C991C69DBE012C0B" modified="2018-10-10" version="1">MNHGDKSRRDSRSSRSSRAGTVSRELDGSDRDESSPRSQSAPTITHLFINNSRVMSRSQNWTNVLDPVSQRLLCRVPGSTLQEVQRAVEVAQDAQPGWAGMGFQIRREHLLRLVDVLRQMSPEIVTCLSREVGKTLADADAEVFRGLDCIHAACSIGPEMAGMFLGGDATLLQTFYEPVGVCVSITPFSFPFMIPLWSLPYALITGNTVILKPSEKTPTTSSLLAAAFLKTGFPPGVFNILHGGPSTVQMLVSQPSVQAVSFVGSESAAGQVHDLARAAGKRIQAECGGKNHGVVLEDANMMPTLFAIAGSAFGAAGQRCMALSVAVFVGTTREWIPKLVELAQSMVVGCGGNQESKMGPLIDAAAKTHVSGMIQRAIEERATVLLDGRDIEVPGYPDGNFMGPTILTEVETYMECYQAEIFGPVLICMEVDTLEEAIDLINQNKYGNGCSIFTTSGKHANTFQRCVNVGQIGVNIPLIAPYGTAVRTSNKDSFLGDRHTPGKTYWPFFTTTKTVSSRWDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WXN9</accession>
    <name>A0A317WXN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_40522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468459.1">
        <property type="nucleotide sequence ID" value="XM_025607386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WXN9"/>
    <dbReference type="GeneID" id="37109529"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="173" mass="19396" checksum="FCA74838276E100B" modified="2018-10-10" version="1">MVKRVKKIMEKMGGLDATIVWQRQCRERSGNKEREGRGATMEGRRKGAGGESETDGVASWPGIVAQQVTAARRYRQVLGNRENRRKKNPETTNKSTARCRKSQKKRQGRRRSYVIAGCGGPKRFVVRLASIAMESRLAFPPWPKSPSLGGDDEARLVYSINGRHGRTILVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYJ4</accession>
    <name>A0A317WYJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pyruvate carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_555305</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469204.1">
        <property type="nucleotide sequence ID" value="XM_025613784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYJ4"/>
    <dbReference type="STRING" id="1450535.A0A317WYJ4"/>
    <dbReference type="GeneID" id="37115927"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007:SF1">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="7"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="125"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="564"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY91476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="70782" checksum="BF2735D22F2AE63C" modified="2018-10-10" version="1">MKSSSKPFRRLLVANRGEIAVRIIQAARELSPPLEVFAIYTDDDRSHCEIGHPDRALLIPSVATYLDISFLVRLSQEHAIDAVHPGYGFLSESADFSAHMQNAGIAVVGPGREALARTSNKLQAKQLAIECDVPVLPAMAQPTADIAMVQAFAKQVQYPVIVKAVDGGGGRGIRLVRQDDQLERAVRGAANESPSQTVFAEKAAVTGFRHIEVQILGDGADVCHLWERDCSIQRRFQKVVEQAPSLINNRILVQQVVDAALRMAKTIRYRSLGTVEFLVNEQQGEFYFLEINPRLQVEHTITEAITGVDLVQAQLRLAQGYTLAQLGIPAAQSATPRLHSIQLRLCAEDPRNQFALSIGKVSELVVPGGHGVRLDTHVGTTATGPVVVGAQLDNLLAKIIVTASTREGAVLKARRVLADTRVTGVRTNLELLRGIVSHEDFVAGSIDTQWLETSLEQVLQRGAVRIQQPTQGPRPSTLPSIPSSTLLFRRGDAWSISLAPVDSPEQSQPHQHHLQLTRVLRNDFPTSLAAEIKYQTPTFSTVYRLQLAATSTAASALLSSSHRRGDLSNPQHIVLPLSGKLTEVLVSAGDTVAENQVIAFVKQMKMEVEVRSPRAGRAQWVYEMDDEEEDVAEGMLLVELTDGLQGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYR5</accession>
    <name>A0A317WYR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_396630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469264.1">
        <property type="nucleotide sequence ID" value="XM_025607363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYR5"/>
    <dbReference type="STRING" id="1450535.A0A317WYR5"/>
    <dbReference type="GeneID" id="37109506"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000882">
        <property type="entry name" value="Translation initiation regulator (Gcn20)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="199"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="531"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY91536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="751" mass="83068" checksum="4756AF649B105388" modified="2018-10-10" version="1">METELQAQIPGLDRVISQYSVGYLTHASKAYVEDANAPSPLAEAADLVTELLVSASGDFTPENEKAIRNLVEKFISSLSASDGVDAERRQMPFAAKRLDQAINVGSQRNMSSTLGLAGGNVDLESANARKVESRVDRKKLEKAERKIRAKQEKKQMKTVQYESSRLLNQPDSTMSYEEFFMAVNPLQLGSDSQSKSKDIKVDSIDISVGGLRILTDASLSLAYGRRYGLVGQNGIGKSTLLRALSRREVAIPSHISILHVEQEITGDDTPALQAVLDADVWRKRLLADLEKISKQLAEIEAERSSMADTSKDAARLDHEREGLDITLNDIHAKLAEMESDKAESRAASILAGLGFSAERQQFATKTFSGGWRMRLALARALFCEPDLLLLDEPSNMLDVPSITFLSNYLQTYPSTILVVSHDRAFLNEVATDIMHQHSERLDYYKGANFDSFYATKEERKKNAKREYEKQMAERAHLQAFIDKFRYNAAKSSEAQSRIKKLERMPVLEAPESDYVVHFKFPDVEKLSPPIVQMTDIAFGYTPDKPLLRNVDLDVQLDSRIGIVGPNGAGKTTVLKLLTGQLQPTAGLLSQHARLRVGYFAQHHVDALDLTTSAVSFMAKTYPGKTDEEYRRHLGAFGITGMTGLQRMELLSGGQKSRVAFACLSLTNPHILVLDEPSNHLDIEGMDALSEALQNFEGGVVMVSHDVTMLQNVCRSLWVCDKGTVHKFDGTVNAYKKLISSQANEAGVAAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ43</accession>
    <name>A0A317WZ43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_623062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469374.1">
        <property type="nucleotide sequence ID" value="XM_025617123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ43"/>
    <dbReference type="STRING" id="1450535.A0A317WZ43"/>
    <dbReference type="GeneID" id="37119266"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="34558" checksum="88780C15B8683FDC" modified="2018-10-10" version="1" fragment="single">MTSPANHLPAHVPLTHMPQQGNLWSAEDDWTGVTDRHRRRQLQNRLNQRTYRMKRKAAANTRLAIEPSTATTPSMSTDVVQRAAYPLSHAADTEDNDLDCRLTPPGAAQYRRQFEAIAHQSFLLGSPQLEHLITLRRLNVHRAINENIRAIGMTPEWTKPDEAISIFNLPLPLPGNYDEERIPASLRPTVIQRLVPHHPWLDFFPFPRMRDLMILAGDSLDEDDLCRDLMAFWDTHNTGATLLVWGESWDPQNWEATEEFVRKWHWLLAGSPELLASTNFWRAKRGDRPLSWRSLLRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZE0</accession>
    <name>A0A317WZE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_462797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469079.1">
        <property type="nucleotide sequence ID" value="XM_025607989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZE0"/>
    <dbReference type="STRING" id="1450535.A0A317WZE0"/>
    <dbReference type="GeneID" id="37110132"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="682"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="192"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY91351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="730" mass="78681" checksum="A751A771E2CC3CCE" modified="2018-10-10" version="1" fragment="single">ISLHGAGTNSRIFEIQTAAIRYELGDNHTYDFVEGTIPSKMYPGVDVVAWKDEPMYAYFDERHPESGFAAYHYLEEYLHDEGPYDGVIAFSQAGTMILTYLIHLAKQDPRDEMPFKFAIILSITHPPLDYQALQNGRVMAIDLEAAADIIPIPTAHIWGSRDEAANRVATTNTVCKADVRWVYVHSRGHEVPGAGIALSLFLATAEITIISTSLVTINEHLEGGEQSTWIITSYLLTFTGFLATWAKCSDAFGLKSALLSSLLLFIAFSGGCGAAQSIDQLIICRAFQGIGGSGVFSLGLFSLVRIVPPEKYDTASAVGSGVLTLALILGSLIGGGISSSGAWRWIFLFNVPAGGLAWILLCLLVPRNFARRVTTRRSDGLVRHAQSQLREFITHADSVGCLLLLAFSMLLVAALEEANVRYAWSSGIIIGFLAGSGVLLAAFLGWEWTLSTRKHMRMEPMLPWQLFKSRVVLGIVMSVTISLTYSASATSGFFLTGPAVTILYIELPQRFQAVNNFTAIEAGVRVLAFGAGSPVGAICCTILAGRLATPFVYLTLAGSVLQIVGAFLLSSVPATVDAWPGEYGYMALTGLGTGISIAALYMCLPIVVSESEQAIAMGLTLQARMLGASLGVAIVNSILVNYVKAHLPPTEAAADPSHLSGLPMDIQDTVRTEYATGYNHQMYTVGACGVAQLFAVVLMWKKDQVRFVRQVKVNRALGHETELDPGSLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZL7</accession>
    <name>A0A317WZL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_380329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469537.1">
        <property type="nucleotide sequence ID" value="XM_025607258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZL7"/>
    <dbReference type="STRING" id="1450535.A0A317WZL7"/>
    <dbReference type="GeneID" id="37109401"/>
    <dbReference type="OrthoDB" id="5988157at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69360">
        <property type="entry name" value="Cell wall binding repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="190" mass="22604" checksum="54FEE5DECC2FD3CC" modified="2018-10-10" version="1">MLLQDLTRKNFHLLGLLDRMMLPGLAVDRSGQKRQKWTEVDRSGQKQQEWTEVDRSGQKRQKWTEVDRSGRSGQKWTEVDRSGQKWTEVDRSGQKWTEVDRSGQKWTEVDRSGQKWTEVDRSGQKWTEVDRSGQKWTEVDRSGQKWTEVDRSGQKWTEVDRSGQKWRVDRSGQKWTEAEMCTEVDRSRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0E5</accession>
    <name>A0A317X0E5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_489862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468826.1">
        <property type="nucleotide sequence ID" value="XM_025609103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0E5"/>
    <dbReference type="STRING" id="1450535.A0A317X0E5"/>
    <dbReference type="GeneID" id="37111246"/>
    <dbReference type="OrthoDB" id="5130616at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22159">
        <property type="entry name" value="F-box_AtTIR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="438" mass="50473" checksum="BF49B5D584317434" modified="2018-10-10" version="1">MNRLPDEILLLIVDNIYLHRDKRNFLLVCRRWRSVLYKSVNRNVWINGGCIRPLVLAIHDNPALGSAIQSLRLHWWSSYTRKAENHDITPVIPLVAQISQSEEETKEWEEALKEGNQDAWLGLLLLSLENLIELDMHYTWNPIFLRRVISRAAMREYPLDTKPVLQRLEAFYVDASDDNKAYFPSVEFLPFFRLPSMRTVSLDSVVESLHREIDHPAFKASRGTSPIVSLAFDRHSNGSKGMAEFITSCANLEQFEYSHSNQAIWGEQYISFRPRAFYTALCSQKHSLQVIHLDDTDELTGAESDEEDPNDLPDNWLGSFADFNKLWDLQVSVANLLNFHKSDQVPRVSSLKEILPRSLKRLHLGRFQISQLDLVRSNLLEVVACREEFPHLEQLELETGFKQLIQQESGPPLTIKQALAPLIDACEDVGIKMTIVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0Q1</accession>
    <name>A0A317X0Q1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Zinc finger protein ZPR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_378784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a protein folding chaperone for elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469479.1">
        <property type="nucleotide sequence ID" value="XM_025607244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0Q1"/>
    <dbReference type="STRING" id="1450535.A0A317X0Q1"/>
    <dbReference type="GeneID" id="37109387"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000002">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000004">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="35"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="10">
        <location>
            <begin position="250"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY91751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="470" mass="52518" checksum="0CE20A9A3F404CFE" modified="2018-10-10" version="1">MSAEGDNTTQAESQFQKPGDLVERNEDTGVMQVESMCMNCHDNGVTRLLLLRVPFFRDIILESFECEHCHFKNNSIKSAGQIQEKGAKYTLDVENETDMQRQVIRSDTSTFKVETLGIEMPKGDGQLTTVEGVIQTIYESLSSEQPLRKEQAPELHNALVPIIDKLQKIMDRDGYPFTISLDDPTGNSWIAPTTQDSGNKYKRRDYPRTHEQNEELGIAGDPNAVQNEGVAEAEPEDDEIVSGKVYSLPAECPGCSKDCFVNMKKVDIPYFKEVFVWATACEHCGYRTSEVKTGGEVPEKGKRITLSIENEVDLSRDILKSDTCALHSEELEVTVQPGTLGGRFTTVEGLLTEIRDQLHGQIFDVDDTTGAGGDSMASSDKEKWERFFKRLDAAISGEMKFVITLEDPMANSYVQDLCAPAADPQIKTEEYTRTDEEEEELGLKDMKVEGYEEDEKKDDKPAEGAAEQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1U7</accession>
    <name>A0A317X1U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine-specific metallo-endopeptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_573948</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469255.1">
        <property type="nucleotide sequence ID" value="XM_025614996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1U7"/>
    <dbReference type="GeneID" id="37117139"/>
    <dbReference type="OrthoDB" id="4453622at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="38631" checksum="C048E977F2D9D337" modified="2018-10-10" version="1">MWLLRQLLSPALVLVGHGALTLAATALPMAKLFDVVTDSSLNGNCAAYSTATLDQLASDALKLAEAGSKACDSYVAADPAMVRLFDAFFQGTDATAVAGMKLWYDYVSNWLQNGGVLSGRTKLPLLFCGDHSIRQTMSSPLRDDDGNTHQNAQKTGDTLIVQDSYMKDWWKQVAVAQQVVLTAVYPYWDPQQLVYFFDQKKGSSVTDYQCADDSLGYTIAQGRGSVTLCTSSFSAGGNLGSVAPSPIPAKDFVNGNPPSNQAAQPIDDIMPGAATLFHELLHLFSENKFVPSTGEEYNAWRIMGKMVRDDNTYFTGDNSVDNAESYTFVAGAAYYTQNMPSNGKVVEYYTGYCSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3W7</accession>
    <name>A0A317X3W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor hoxa13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_532982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470017.1">
        <property type="nucleotide sequence ID" value="XM_025611242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3W7"/>
    <dbReference type="STRING" id="1450535.A0A317X3W7"/>
    <dbReference type="GeneID" id="37113385"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="857" mass="94067" checksum="9A13DE684D90ABC3" modified="2018-10-10" version="1">MAIPDNSNAPEGSDRAVESRSSGLKSSRRGTFRWTVGLLVRLCIWYALITPFLRCPSQLSDLTDTSPRVCKPYLVARSYIEPHVTPYYNAYGAPYVETARPYVLVLNEKVYAPTSRVFKRGYERYGAPALDRAHLYGQQQWEINVVPHLQSATDSVNGLYQSQIQPHVKRVEAALSPSLQRVNGAVKSAYGDYLLPFGAKYRPFIGKIYTSGQDMLTTTVLPYAQNSWSTAIYFIHSSLWPRVTGLYWENVEPQLIKIGERLASYREVKRLRQAVEEVETVSEQPSSSPSSPKATEAKDLTSSSTTEEIIMQQTLSPTEQAAKARDSIESDLRTWQQKFAVAAEKGLEDLEERLQEIVDMFMASETRTQGESLTTALEAVVDNEMIALKHHINNLAESLPVEDAPQEEEAAKDELLGNVKEAAVSIRDRAHALREWRGSFERELTYRVSRAINSTLDVLDSVRDLGLQEVGMRWAWMDGVTYKDWARYHALKAQFEDWKDEFLDFGLQHVKLEEARAAADEILSHGMEIAEAAAKELGRLRNVGNWKITAREVSDNFDTRSDLPPPRPKPIPAPEETVGGDAATDGVADNELPENEPTFVFDSTSQIENNGVDGDDESMAGDEEHASPQPGGERSPGYTPTTLGSDSENDIAVTHNTDDTSDLKKTPWGVAAADVTDQNMPDTHRTPGHVPSESDNLGVSGHDLSSEQEAVASLISGLLVGKDAAYAEDIMNKLHSIYGIPRPTPEASVVSDRVPREDSIDADASSASIPVSEDQFSPSLHETDGADDALGTAGFVPSVADDEQSPNSGIDVEVDSAMDSAESHSATLGSTTSSLVSEAAETVFPESTQPVEDNAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X437</accession>
    <name>A0A317X437_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_533451</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469048.1">
        <property type="nucleotide sequence ID" value="XM_025611336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X437"/>
    <dbReference type="STRING" id="1450535.A0A317X437"/>
    <dbReference type="GeneID" id="37113479"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000008">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="15"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY91320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="88" mass="10258" checksum="51AF5EAB18680769" modified="2018-10-10" version="1">MEGLNASEQRELANRMERKQMKEFMSMYSKLVQRCFDDCINDFTTKSLINREEGCVLRCVDKYMKATGRLNERFQEQNAAMMGGGMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4H9</accession>
    <name>A0A317X4H9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_532476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470295.1">
        <property type="nucleotide sequence ID" value="XM_025611128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4H9"/>
    <dbReference type="STRING" id="1450535.A0A317X4H9"/>
    <dbReference type="GeneID" id="37113271"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000227">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032005">
        <property type="entry name" value="TyrRSs_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16714">
        <property type="entry name" value="TyrRSs_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosyl-tRNA synthetase C-terminal" evidence="10">
        <location>
            <begin position="486"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="615" mass="68936" checksum="F721BE1210FB3B72" modified="2018-10-10" version="1">MRFLSGALPRAARLHTPIILSSRQTPCGARNYARTAEVLRMNQSLSNGTRPTIRYPIFSVGSEQNRWISQNYLRKQKEAKEEWAEFAREIKEGKRKNFAQHLDERGLLHDVVGERKVLDRLFTHKRVGMYAGVDPTAPSLHVGHMLPFMVLAWGYVWGLPVTFLLGGATARFGDPTGRLNSREQVHSSVRKANMASMHMQLKKLGNSVFMYGKRHGYDLERARRALVNNNTWWNSLPLVDVFRDLGVHTRLGPMLGRDTVKNRLTKGDGMSFAEFAYPLMQAWDWWTLFQKGVQVQVGGSDQYGNILFGMDAVKSISKNNVDPLHKSDLDDVLDRPIGITTPLLTAPSGEKFGKSAGNAIWLDKDMTSTFELYQFFVRTPDDTVERYLKMFTFLPIPEIAKIMEEQNKDPSKRVAQHALAAEFVELIHGKVEADAVALQHRQLFRPRSSTAEPSPLPLKPSSPGNAQSPTAGFDNPQSGNAYAPQTNFANMPKTHVTLPHSLVYNQPMHKVLWSAGLVTSKSEGHRVIVNRGAYVGSRPGDSGPMSDDLAFTPVRTWPVEKTETFILGGNTLFLKLGKWKFKIVKIISDEKFRAAGLTAPGWEEKTTRSNKGGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4W0</accession>
    <name>A0A317X4W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_615050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470400.1">
        <property type="nucleotide sequence ID" value="XM_025616751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4W0"/>
    <dbReference type="STRING" id="1450535.A0A317X4W0"/>
    <dbReference type="GeneID" id="37118894"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="453" mass="51306" checksum="F5D7619072F082FB" modified="2018-10-10" version="1">MVELWSWALGNAPSTVGYRSFFEPRWLLGFRFTRGGQEMLRQGYQQASCRRRRQAPPKALFNKGLGSYTGLSIILESRLHIQVIQQRLTPTLATVMGEVKDELEYAFHSGDLPDCLDTWVSVDIHTTLARLISLLSSRVFGGTELSRDEEWLSTSTQYPKNAFATAMALRMVPVVLRPFIAVLLPHYWHTQSNLASAKRIIGAIVRRRRTAGAEHEGAYKKPNDLLQWMMDAADERDGRPDKLGHRLLFVSDASIMTTSLLITHCIYDLCAHPQYLVPLREEILAVLREGGDFQKTMLHKMRKLDSCLKESQRLNPPFLMTFDRILREPITLSDGKRLPVGAHVAIATDAMLHDAHYLPSGGADPDSFDPFRYARAREDPGKPENAQRYQLATTEVTSLPFGHGKHACPGRFFASSQAKLVLCHLLLRYDFCLPEGKTRPKNLLFFGECRTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X538</accession>
    <name>A0A317X538_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cell pattern formation-associated protein STUA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 10">Cell pattern formation-associated protein stuA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Stunted protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_461050</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470082.1">
        <property type="nucleotide sequence ID" value="XM_025607908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X538"/>
    <dbReference type="STRING" id="1450535.A0A317X538"/>
    <dbReference type="GeneID" id="37110051"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000003">
        <property type="entry name" value="Ascospore maturation 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="12">
        <location>
            <begin position="337"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="451"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="561"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="625"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="680"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="767"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="681"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="767"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00073215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY93321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="856" mass="91038" checksum="43DAF9A1A93C78DC" modified="2018-10-10" version="1" fragment="single">IGLPSWSVGASDLICSGLARVELFLNGCSTLQNWTTKNKKRHLLSHGTPDTFLSPSSDRSRSSHFSKPLPPPTEKLELPSISQVHTRGPVDIPWYNHHAAERPLLSGDKLPALSLPTATQAISGQSYRTSYEDASALGSNNTSARTSLSGAAPVVSEARSPPPSSADLAAGGQGRLSLDSSAPQDYTLQQTPVSDSYYQSQTPIGSMNQTQPYIDVHSSHISSAQPYASHAATAGGIAHYPQYHQQPPVLQPASTTYGPTTSYSQYAYPSGVTSSQAGPQPPTTSMSGGVPAQLLPLPAVTNHAAAPPGYGNTTGTPLQGFIYDMTGQVAPPGAKPRVTATLWEDEGSLCYQVEAKGVCVARREDNHMINGTKLLNVAGMTRGRRDGILKSEKIRHVVKIGPMHLKGVWIPFERALEFANKEKITDLLYPLFVHNIGGLLYHPTNQSRTNMVVQESQQRRLEGPQAARASQGPQPQTLHHHHSLQTTVPSHMPQPHAMASQAGARPGLDRAHTFPTPPASASSLIPITNPGNSYDWNNQGMNSGVPNSQPLSIDTALSNARSMPTTPATTPPGTNLQGMQSFQGQSGYESKQYYSAAPPSHPHYASQQPLTQAGMASYGQTIPSHPYIKNEMGPPSSRTPGGQPETEAPEVKQERYAHSNGHVGSNGAESVAEHEPEYVQHDSSGYNTNRGSYTYTTNTSVGSLTGDHSQLTPEITGSPTQQNGSGRMTPRTSGGPPPPWASGYNTPPRPAAASSLYNIVSDTRGTSGNGTAADNYSVTSNSAPGYSTGMNGSLGSTKRMREDDDVDRIPRPDSRGTEYDSKRRKTLSETSVGGPVGGVPLGLQPMKAGGVMARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X593</accession>
    <name>A0A317X593_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_351973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470527.1">
        <property type="nucleotide sequence ID" value="XM_025607109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X593"/>
    <dbReference type="GeneID" id="37109252"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="149" mass="17199" checksum="76BDCAA756B456FD" modified="2018-10-10" version="1">MVKPRLRPDLSLSVEDQNEPPKWRPRGRYLGDQCPHKHNESRHRLFTFPDLGRIMAPSVILPMNLLPTSQELNPWALIGAQHLVILGFSLGPQMITRAAPMPIQLCYARINEQTLFYSKKFVSTKCETKRLMGTWVQGSVHFRRPTDHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5E8</accession>
    <name>A0A317X5E8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_532495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470316.1">
        <property type="nucleotide sequence ID" value="XM_025611130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5E8"/>
    <dbReference type="GeneID" id="37113273"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="54" mass="6168" checksum="1F222952D356ABAE" modified="2018-10-10" version="1">MLTFEAPGQSIVPRRMLWSPQRYAKPFARRFINSWLSGWLFNGVVNSSGNLVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5G5</accession>
    <name>A0A317X5G5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UbiA prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_420547</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470615.1">
        <property type="nucleotide sequence ID" value="XM_025607401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5G5"/>
    <dbReference type="STRING" id="1450535.A0A317X5G5"/>
    <dbReference type="GeneID" id="37109544"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF39">
        <property type="entry name" value="POLYPRENYL TRANSFERASE AUSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="273" mass="29461" checksum="DC70439D823AE290" modified="2018-10-10" version="1" fragment="single">PSSLSEESEYTPPQTGLLSTLPSSWVPYAELIRIDKPHGIYLVWVPHIVGLAYASAIGPSPAPLHTLYTRALRLMLWAALCRSAGCVWNDTVDQDFDRKTARCRNRPIARGAVTTSQAHIYAAVLFSLALLSLKGISSHAMTVAGIVALLSLVYPFCKRFTSFPQVVLGCSLGLTVVLSAWTLDVDVLAGRNRIPTMCLMLAIVLLIVFYDVVYATQDTADDVKSGVKGMAVLFRNHLLVLLWGLVCGIAGVLSVLGVLVGMGLQYLVFSVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X774</accession>
    <name>A0A317X774_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_275145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471205.1">
        <property type="nucleotide sequence ID" value="XM_025606587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X774"/>
    <dbReference type="GeneID" id="37108730"/>
    <dbReference type="OrthoDB" id="5285218at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="75" mass="8652" checksum="4AE4F36127F9B548" modified="2018-10-10" version="1">MGFIEKLQAKIELYRLEQRYARRKHRSTFSGVTYVDGEYVYVNGSNSSSGTVSKHSTGSYWKPPTWGLSGDSRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7S6</accession>
    <name>A0A317X7S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking PGA2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_531600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471425.1">
        <property type="nucleotide sequence ID" value="XM_025610936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7S6"/>
    <dbReference type="STRING" id="1450535.A0A317X7S6"/>
    <dbReference type="GeneID" id="37113079"/>
    <dbReference type="OrthoDB" id="4227028at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011431">
        <property type="entry name" value="Trafficking_Pga2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28199:SF1">
        <property type="entry name" value="PROCESSING OF GAS1 AND ALP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07543">
        <property type="entry name" value="PGA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21260" checksum="0A480A83F15AAA08" modified="2018-10-10" version="1">MATRDPGEVAADALNDFFSQIYSFCETIFTRFFGNLYASFADVSINRWTKVICSVIGYLLLRPYIEGFFKKMHDRERRKIKEKEEAKKNEKKAKVSANTLRGGGGGGRVLGEVENTDDEIEDGEDFATASGVPEWGKNARKRQKKYLKSLEKEAASRTHNLSEDQLMELLDWSDSEDEKRADKKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X857</accession>
    <name>A0A317X857_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase 19.3 kDa subunit mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_487404</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470603.1">
        <property type="nucleotide sequence ID" value="XM_025609033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X857"/>
    <dbReference type="STRING" id="1450535.A0A317X857"/>
    <dbReference type="GeneID" id="37111176"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="107"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="232" mass="26061" checksum="A36AFE5AD6DB5DAD" modified="2018-10-10" version="1">MLPLTGRAIPGAIPSAFHVRPYLTPRRFRIQPVSFLSTSSVKSATAIEQRGQSGHALTASGKVRKEVPLPSQEKKEGAMQYVLTTLDQVANWARQSSLWPMTFGLACCAVEMMHLSTPRYDQDRLGIIFRASPRQSDVMIVAGTLTNKMAPALRQVYDQMPDPRWVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDVYVPGCPPTSEALMYGIFQLQKKMRHTRITRMWYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8M2</accession>
    <name>A0A317X8M2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_531577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471396.1">
        <property type="nucleotide sequence ID" value="XM_025610933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8M2"/>
    <dbReference type="STRING" id="1450535.A0A317X8M2"/>
    <dbReference type="GeneID" id="37113076"/>
    <dbReference type="OrthoDB" id="5327951at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016378163" evidence="2">
        <location>
            <begin position="27"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="526" mass="60621" checksum="2780BE2FCE19E42D" modified="2018-10-10" version="1">MYLPALSQSLLVLALALLIPLWPTSTLPLLNILKSFTSKPTMAGISETQKAQLQEVADLMLEIYQTLARMRYLDPRGIQIGPHNITELRPLYEQHGLDPSIIYLYSILPYVDTAAAGNEDFYNGGEFTDFRTEDDVEQGRDPFYAGPTDEDFDDEDGPYIRPWVTPLSRLGNHQSVIVYDARKHRIWIIDQEGWCSTDPALEDVEEETPKSKNRSNFDHIPSRPAGDVLRDIIRWYRELKELPGGGEHSGGEWDHEDLDLKGLYRKHGWPDNFDGDAFQVDKARAYCADRVKYGAEEPLRAVERFKNWKEWSGNTIQDRRKAIAAAKSPDEEWVTRLELWDAERSYRRHTEELKKAEQEASRLCPDGVCLKLEDIPLLELDSVRQEYEYKQREAEDERKWMEETPESNPEDAERFQNSFYLAEKEAAIYRKAWEAAKADAERLCPGRTLNVTGPETSEQERTMAEVQRMEDHAMSVQLELAALREWASQIPDDATTAKDKANSKIQTYQQWWDDGQARIATLKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8U5</accession>
    <name>A0A317X8U5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_531983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470778.1">
        <property type="nucleotide sequence ID" value="XM_025611021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8U5"/>
    <dbReference type="STRING" id="1450535.A0A317X8U5"/>
    <dbReference type="GeneID" id="37113164"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="39847" checksum="4D1CE4668CC9838D" modified="2018-10-10" version="1">MNSLPTFIKSIQQQKYHALNPKTSKSTYIFLNLQDNTLNDIDKSYNSNTQITVNPNHPHYTLGTLSTLPLEIIHLTLLHLDIKSPITFQTLNKHARRTAHSLPQYKRILTHTPALIRATLNIQTAQYFTLQDLHNQLTTTKCDSCGDFAAYIYLLTCRRVCFLCFTQKTAYLPLSQEDVIRKFGLQSTHLAGLPHMKSFPGCYSPRGLERRRRKTLYDYSARRKTGIRVHGTVKAMEKFSAEVLSEKLKTYFLCINHKMRVTRPICRDSFDDRSSNPKRFMGIIRVPCFRIEFKPGGSLEWGFHCLACKSLHCDRPLHWGRMFTTESFRAHLAECGAVVKGRYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8Z0</accession>
    <name>A0A317X8Z0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arrestin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_553919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470838.1">
        <property type="nucleotide sequence ID" value="XM_025613681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8Z0"/>
    <dbReference type="STRING" id="1450535.A0A317X8Z0"/>
    <dbReference type="GeneID" id="37115824"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="5">
        <location>
            <begin position="148"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="430" mass="47636" checksum="E662B418EBD98AEF" modified="2018-10-10" version="1">MLRQSLKNAKKATQRLYTRDDPSDLSLELSITEPAVFVPTYTDKPAVLRGTCQLKVKGNLAVKRLTVNFRGTSRVTWPHGLHDTQTVTDSTLTLLSPQASDAALPSYPGSLCDETQTSSLGKRWRLWNAVTSTLCSNGSYGKVSGPKYQRLSAGTHTYDFEMVLHSHLPESVQIRQSQVRYQVRACVECPGFLRRSVARNKAVTTVHCPAEDNVEDAEPVYIARAWKGLLQCGILVSRRGAPLGDRLPVSVSLTELAKAEFRGLRVFLSENVQYHQRDGLACCPGPFRRVLLYEKVEGSVSTPSLHRAGNADDERPESEAKDDGGMEKMIGDPEIPSGRVPDEEETTLDLTLQLPGCHLHSVPDGTQSMHYDTRYKNVRVSHWLEFVFVVCPKESLGSSNDRIVQKMAKVPLALRSCYAQYASASLPAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9F5</accession>
    <name>A0A317X9F5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_553075</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471890.1">
        <property type="nucleotide sequence ID" value="XM_025613634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9F5"/>
    <dbReference type="STRING" id="1450535.A0A317X9F5"/>
    <dbReference type="GeneID" id="37115777"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052128">
        <property type="entry name" value="Oxidoreductase_NAD-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46505:SF1">
        <property type="entry name" value="OXIDOREDUCTASE NAD-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="4">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="342" mass="38417" checksum="5F6ADA71CA84E96C" modified="2018-10-10" version="1">MSSPTSRKGSQPHQLRTAAEPRQNRLYNVRLSHIEQVNPSVRLLQLTIPPEIQNEDEDQDQDLDQTIILNHHPQPLTFLPGQWLDVHIPSISNAGGFSITSTPADAQILPSLEPPITAVDESDNPPIDPHGRPPYLELAVRHAPLNPASAWLWRPAHEILGTELSVRVGGSFVWPPSGVDLTRIRNVVFIAGGVGINPLISMLSHLNNGDDEATALQHPNLNIRFLYSTKLPREEGNRGRRSLEQVLFLSRLRQIIASQSQFRRLRIELDLFVTDLEQGEGEALLVGEREDLTLHARRINQRDLEKAISGSDGKVKVEETVCYVCGPPGMTDELRVYYEKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9I1</accession>
    <name>A0A317X9I1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gamma subunit of 5'-AMP-activated protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_554069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471038.1">
        <property type="nucleotide sequence ID" value="XM_025613696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9I1"/>
    <dbReference type="STRING" id="1450535.A0A317X9I1"/>
    <dbReference type="GeneID" id="37115839"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="233"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="307"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="378"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="441" mass="48686" checksum="A72E12E64928D830" modified="2018-10-10" version="1">MEEAPQREAPTGRMSPSGLPPSTDDTTTTTTTTTSTTSTTTTTTTATTTTTAVASPPSTPTLIDSAQFHIHSPSSTGFFLSSNPSLVPDRRPARGHEGAFVHPASFLRPRGLSHPMPPAQPERAIDREERRALRAIRNFLKVRTSYDVLPLSFRLIIFDTSLSVKESLNILIQNGIVSAPLWDSKSSTFAGLLTTSDYINVIQYYFQNPAALNQIDQFRLDSLREVEKALGVAPPETISIDPERPLYEACRRMLESRARRIPLVTHDSQTDRALVLSVVTQYRILKFVAVNVSDTQKLRKPLGELLLGSYHNLATASMDTPVIDVIHILVERSISSVPILNSEGVVYNVFEAVDVITLIKGGVYDDLSLTVGEALKKRSPDFPGIYTCSLNDGLDTIFDTIRKSRVHRLVVVDDNFRLKGVLTLSDILQYILLEGETDEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9P0</accession>
    <name>A0A317X9P0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_508375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472015.1">
        <property type="nucleotide sequence ID" value="XM_025609659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9P0"/>
    <dbReference type="STRING" id="1450535.A0A317X9P0"/>
    <dbReference type="GeneID" id="37111802"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF24">
        <property type="entry name" value="NUCLEOTIDE-DISULPHIDE OXIDOREDUCTASE AMID-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="14"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="419" mass="46533" checksum="B15B16F14DA876FB" modified="2018-10-10" version="1">MPSVTSVSSLSRQFRVLVVGGSYGGLSAALTLLDLSHGRVARFNHTPDAQPPQKQIPIQITVVDERDGFYHLIGSPRALSCEKYASKSWTKFEDIPALNSPSIRFLRGSVNSVDCQSKVARILDAHTKETRKEKYDFLIASSGLRRVFPTVPQSLRREEFLEEAKKHTDEVRNSQDGIVVIGGGAVGIEMATELRMLHPDKKITLIHSRDRVLSAEPLPAEFQDRVGSLLREAGVKVVFRQRVVDITAIETEGGRRIWKLELADRRNIYAGHVMNAVSKSVSTSTYLPKEALTEDGYVKIRASTQFPQNVPNADHHFAVGDMASWSGIKRCGAAMHMGYHAGNNVHQLMLSEISKTKPEYISLQEVPPVMALAMGKTAVTYTPAQGTKDGEDVHDVMFGEDMGYSICWNYMRMSEPYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBH1</accession>
    <name>A0A317XBH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_215190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471718.1">
        <property type="nucleotide sequence ID" value="XM_025606183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBH1"/>
    <dbReference type="GeneID" id="37108326"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="50073" checksum="9E67785399846845" modified="2018-10-10" version="1">MALYHYNRKQRLLLSSFAILFFTLFVFCHFRSARDPGSWFFQPNEGYRPGYSLHRIQESSEWLSAFNHSGAGSHHSVPVVNPPREKTACVGIVTVKRPLQQDLDTTVASILDTLSPEQRSALTVQVLFALSNPSDHPDYNQTWVSNIVDHVLTYDDVDAPGYIIRNLEKKNNIKKKSLIDYRLGLQACYDMTDAPWIIMLEDDVVAQRNWYEHTMRSVQQVEDWRRQDAIKDWLYLRLFYTEKFLGWNSEHWPIYLSWSVLIVSLCATAGIYTRRTIRSTQGVLTNSFLLVVCFVCVPLLIGLFFLAGRVTWYPMQDGVHVMNAHGCCSQALLFNRENVPELLKYFEHMEDVVPTKAVDSVIELQAERYDLDRLAVSPSQMQHVGAVSYKEKKKTWKWEGPYRVKGAHGVWSMGFEQAYGMQSDRWFDFGDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBL2</accession>
    <name>A0A317XBL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_128039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472262.1">
        <property type="nucleotide sequence ID" value="XM_025605622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBL2"/>
    <dbReference type="GeneID" id="37107765"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="193" mass="21476" checksum="1D88EDB17BA43A0C" modified="2018-10-10" version="1">MAWRTGTDQPCQPWRWPYSADPGGWPGRLCVSALQPSCSFPWMFYYVRRVLSIYRVSTQYQVDTILGMCVSPTLETTRRPSSTLRTRSEANSMTKIARLVPTRVSPRTPTFVLGSHLRCVQSGWSAALGPRHSLVVACPLHPWAQYPPHFTRSPSKPSLVSGDSWPPAAVITPGTDDEAGSQALFWSSPLHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBS5</accession>
    <name>A0A317XBS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_552809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472730.1">
        <property type="nucleotide sequence ID" value="XM_025613622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBS5"/>
    <dbReference type="GeneID" id="37115765"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="37"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="456" mass="50188" checksum="5BDD5B6D4322987E" modified="2018-10-10" version="1">MGWVHHASPELEAVSQYRLILGVCLSLTLLMIITVCLRLAIRFQARRLEASDYVMLVTMWFSIIYSSLCIAQTRYGLGLPLKLRPKADLPNYTKLNYAGRPFYQLGIAGFKASLCLNYLRLLSGTSKTYYRILIYVVIAISTLGHFAGTLVLIFDCHPINRAWDLTISGSCLPAGPTFYGLAIFSIICDIVIICLPIPLLLQLNIKPAQKAGIVCLFLLGLFTTICSILRLTQIYRVAYGDGNSSLLVLWGTIEFNVGNIVTCVPFLAPLLKGAVRDFRSYSGPKGYNGRSYALQSWSRDPRSQLKSTTSAAPQPKRTPSEELILDSGDPEEGGIHMTVELHVSTEKRPTEDHDQGSAGSRASEANEPLASNGIFPAIKLSSIQKESCAFRETLKWSTRKDIPGGRPGWCVPRAYGWSTRTKAEGGPRPRPNSPSALKSLLGLTLSHTSWGRVTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC31</accession>
    <name>A0A317XC31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_483761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471928.1">
        <property type="nucleotide sequence ID" value="XM_025608934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC31"/>
    <dbReference type="STRING" id="1450535.A0A317XC31"/>
    <dbReference type="GeneID" id="37111077"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016248789" evidence="5">
        <location>
            <begin position="17"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="525" mass="57333" checksum="EF8050385D6E6317" modified="2018-10-10" version="1">MIAAALLLAVAVPVLAGPNTDAVSVCQHLHTVYPQYTVWDPTGTYATETFWNQSYYTNTVKEYWNGVNADNRPACAFFPANAEQVSVAVQQLNKYPTAPFALKSGGHNFNAGFSSTNGGVLLSFNENLSSTTRNPDGQTFDVGPGARWGDVYTVAEKTNQVVVGGRLANIGVAGYTLGGGLSYYSAQYGLACDNVVNFEVVLANGTIVNANTTSHPDLFWALRGGGNRYGIVTKFTIQGHPLGTNGQIWGGMRFYSADKRQQIFEALSNFTRDYPDAKAAVIPTFDFGLPGALVSNPTLFFFYDGSKPPANAFVGLDKIESLFSTTKAQSYTELTNEAGGAKIYGINAAARVNTFPNMPPAQMSQLLETHWTTYQSMIKNDSSRNLDIQIGTFTPQPLSVRIARASTERGGNALGLDPNNGDRFWFENDLIWINPVCNDACPEYLRQVADTTLESFEKTLKGTKPTNWKSGDVDWVSVNPLFMNDAADYQDVYASYGSANQARLENIAKAYDPSRFMFRQGGWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCH3</accession>
    <name>A0A317XCH3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_456421</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472058.1">
        <property type="nucleotide sequence ID" value="XM_025607700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCH3"/>
    <dbReference type="STRING" id="1450535.A0A317XCH3"/>
    <dbReference type="GeneID" id="37109843"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="306"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="79"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="177"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY95297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="670" mass="75140" checksum="BACE541BB65037AB" modified="2018-10-10" version="1">MSTPSTATATHPHQQHYGYPHHQPYQPNASFPTTSAAGTTRLVTSSYPYAVPAPTPTLPFTQSPKIMPTAPTPTTTTISTTTTMPPTHNAVGAGSTAQTSRRRKPNWGEFYKNGIPKEVIVIDDTPPPDQSKGPSRSLATASTATATNGTVPQPAGKRRRTGIDTAYDLGYYDRPSFSINPQQYGEESSAASLSTDRTTSLHTTAPTSLSQGSSGASNGIIYEDANVGQKRKRVTTRKSARDEQKRKELENAGDAFLSYIPPPKPPIKAKDVPVPVIRDYAGRGEKFDDDDGHYIVNPNTPLTDRYSIVKLLGQGTFGKVVEAFDKQRKTRCAVKIIRSIQKYRDASRIELRVLSTLASNDKQNRNKCIHLRDCFDYRNHICIVTDLLGQSVFDFLKGNGFVPFPSSQIQNFARQLFTSVAFLHDLNLIHTDLKPENILLVNNAYQTFTYNRTIPSSSHAISRSARQRRVLLDSEIRLIDFGSATFDDEYHSSVVSTRHYRAPEIILNLGWSFPCDIWSIGCILVEFFTGDALFQTHDNLEHLAMMEAVIGDRIDTRLVRQVMQGGRGTGQNQAAKYFNRNRLEYPNEQTTRASRKYVRAMKQLPEFIPTNTKFHKLFLNLLQQIFVYDPKNRITAKEALKHPWFKESLVDDGTEALRIGEQLQRNNQRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDC9</accession>
    <name>A0A317XDC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_6645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473096.1">
        <property type="nucleotide sequence ID" value="XM_025617587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDC9"/>
    <dbReference type="STRING" id="1450535.A0A317XDC9"/>
    <dbReference type="GeneID" id="37119730"/>
    <dbReference type="OrthoDB" id="5357531at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="121" mass="13302" checksum="11DA6924091ABE8E" modified="2018-10-10" version="1">MYARTAKPKLSLSISAAQNASRQPLSLKSPSSVPRTPISPASPGAKRFSSFQVPSYSYTSACSSKGILKKHSAGAASHAEKRIQFKGTPTVHCVTPIENPEEYYGTYTKLSRDERRWIVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDG7</accession>
    <name>A0A317XDG7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_619758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473427.1">
        <property type="nucleotide sequence ID" value="XM_025616884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDG7"/>
    <dbReference type="GeneID" id="37119027"/>
    <dbReference type="OrthoDB" id="444540at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="83" mass="9081" checksum="A8EDB3ADB2BFA252" modified="2018-10-10" version="1">MSAADSKGTQGFYDELKALFQQADKSGEGKLALPEFTSAVKGSSSGSQLSDAQLEAMFSFYDEEKTGFVSFESVWKKMNSMMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDV9</accession>
    <name>A0A317XDV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A to I editase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_507068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472558.1">
        <property type="nucleotide sequence ID" value="XM_025609600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDV9"/>
    <dbReference type="STRING" id="1450535.A0A317XDV9"/>
    <dbReference type="GeneID" id="37111743"/>
    <dbReference type="OrthoDB" id="10268011at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043829">
        <property type="term" value="F:tRNA-specific adenosine-37 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002466">
        <property type="entry name" value="A_deamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042935">
        <property type="entry name" value="Tad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47803:SF1">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02137">
        <property type="entry name" value="A_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00552">
        <property type="entry name" value="ADEAMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50141">
        <property type="entry name" value="A_DEAMIN_EDITASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A to I editase" evidence="2">
        <location>
            <begin position="74"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="531" mass="56914" checksum="8D5E911F8D7BDB61" modified="2018-10-10" version="1">MAPSNPQQEEESLTSLGERIARLVHAHFDRLPPRSKPILRDDGTREWMPMCGVVVVREGGGLSDGEEEELTCVAVTSGAKCLPSSQLPNCTGLVLHDWHAEILALRAFNHWLLSEVRSILTSPSSSSSSSGPSSESKSTPSKFIQRRTTTSNTENGNMIPFELNPTLKIYLYCTTAPCGDASMELTMAAQDDPTPWEILPSSSSTTPTETKELDLLTGRGHFSRLGIVRRKPARADAPSTLSKSCSDKLALRQVSSLISAEMGLLVNVTPNVYLAGVVMPASEVSAVGCERAFGSSGRMAPLIHSRSQSQYQGEGGDRYHYHPFSILPVEDKIVNGLWQYGKPTSRTDRCKPGTISAVWTAAPSLLSSSSSGGGGDGIGDVYAAQNGAKQLPKLYGSQTGLYETIINGMKQGFKASAPVGKGASALSRARMWGGLRDLALSVSLLGSCEGSGDGDETGEVEEWVNQVNKVAAASSYAEFKRAMLGTPAGRARQRAISEAKKVLVPWVPNEGDDEWGLDVLTIDNKGKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDW7</accession>
    <name>A0A317XDW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_530538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472568.1">
        <property type="nucleotide sequence ID" value="XM_025610694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDW7"/>
    <dbReference type="STRING" id="1450535.A0A317XDW7"/>
    <dbReference type="GeneID" id="37112837"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF43">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41847" checksum="B855077BD56395F9" modified="2018-10-10" version="1">MSELYCPLPPRDQDILRFRSQYGANLGSVFVLGPQLSNSIPREDPAGSSELQFLKKSIASNGLEETRRKWETHWLSALSDDDLIWLKDVAKCRTLRLPLSFYSLGPLFCLGTAFEGEPSQVYHSCWNIVKHLIEKCRYHGIGILIDFHTSSSGINLCANAENRTVARDCVAFLAQEVTFHGMSGVVGLSISSGCESASDMCECYDEVLKIARAIDQSLLIYIDDGQEKSKQQVFGGCKSAIPQFRADFLNGTVQMPSCLTIPQAHVREKTKQATAEQSHFREKASSQTTSSWSPHQRQSFTHGWDLGYSDALRFFGAAIQGILPPRDGADKISALEPWIGQRKRDIQPAQLDEDPSAWEDGLRRGIDDFYKFVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE57</accession>
    <name>A0A317XE57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_530647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472668.1">
        <property type="nucleotide sequence ID" value="XM_025610717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE57"/>
    <dbReference type="STRING" id="1450535.A0A317XE57"/>
    <dbReference type="GeneID" id="37112860"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="339" mass="38410" checksum="4D2CB86865F3A28A" modified="2018-10-10" version="1">MSSSNPTEGQSPAVEHVEVDPEDDVPNEVEDGGYSTDIESYTTSLSASVFDYKWINGRRFHAYREGSYKFPNDEREQDRLDMIHYVFKTAMDGKLFLAPVNVEQPLQVLDLGTGTGIWALEVGDQYPDIKSILGNDLSPIQPTMVPPNVSFEVDDIESEWPPRQPFDLIHGRYLCGSIQDWPKLFKQAYEQTRIGGWIEFQDFHLITYSQDGTLTPDNKIYKWFEYLREACDIMGRPATVGAKLPEYAAAAGFSNIHHRIYPLPLGSWPKEQRLKEAGALNILQFLEGIEACSVATFTHVLGWSLEAVEVFLAEVRADALKKGAHLMQDFHVVYAQRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEA8</accession>
    <name>A0A317XEA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 12">Catalase</fullName>
            <ecNumber evidence="3 10 12">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_562059</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 12"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473426.1">
        <property type="nucleotide sequence ID" value="XM_025614265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEA8"/>
    <dbReference type="STRING" id="1450535.A0A317XEA8"/>
    <dbReference type="GeneID" id="37116408"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000043">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1370.20:FF:000001">
        <property type="entry name" value="Catalase HPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF3">
        <property type="entry name" value="CATALASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 12" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016430802" description="Catalase" evidence="14">
        <location>
            <begin position="17"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="59"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY96665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="730" mass="80501" checksum="D8A46808E0535174" modified="2018-10-10" version="1">MRQFWLLPAVAGLAGAQCPYLSGEMSFTEEADNPTDTIKVVEQAIDNTLYVNDTDSYMTTDFGTPISDQTSLKAGARGPTLLEDFIFRQKLQRFDHERVPERVVHARGAGAYGTFKSYADWSNVTAADFLSAGDKETPMFCRFSTVVGFRGSVDTARDVHGHACRFYTDEGNYDIVGINMAPFFIQDAIQFPDLVHAIKPMPNNEIPQAATAHTSAWDFFSQQSSALHTALWLMSGNGIPRSFRHMNGYGVHSFRFVAANGTSKVVRYRWKSLQGVASLVWDEAQAAAGKNSDYHRQDLYNAIANGRYPRYELGAQIMDESDMLRFGFDLLDPTKIVPEEVVPYTPLGVMELNANPTNYFAEVEQVGFQPGHVVPGIDFTDDPLLQGRLFSYLDTQINRHGGPNFEQIPVNRPRKPVHNNNRDGFGQQQIPTNNWAYTPNSMSNGYPMQANQTHGHGFFTAPYRYASGHLVREVSPTFNDHWSQPAMFWNSLVPAEQQFLVNAIVFENSKVASPHVRQNVVTQLNRVNNNLAKRVARGLGLDEPTPDPTYYTTNKTSNVGTFGKPLLSVEGLQVGFLASNSHPESIKQGQALAAQFAAAGVDLNIVTEAYADGVNATYSISDSIAFDALVIADGVQSIFATPSWSNQANATSSLSALYPPGRPFQILVDSFRYGKPVAALGSGSQALMNAGISLTRPGVYTGSNDTSEIAKEVIKGLYTFRFLDRFVLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF49</accession>
    <name>A0A317XF49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HRQ family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_9337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473183.1">
        <property type="nucleotide sequence ID" value="XM_025617746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF49"/>
    <dbReference type="STRING" id="1450535.A0A317XF49"/>
    <dbReference type="GeneID" id="37119889"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="486" mass="55762" checksum="E758C6B88BA1F1AC" modified="2018-10-10" version="1">MDVLIHQGNLWLVGLAMVALGGFYFVTGKLQGSAILSRVCSHWGSKGGWQSWTAEKKSSPGPSSPATYVDILPPQRRHVLASFKIGVPYEEVDEKDVVEYALPMTSNYQTCTDKRYTPTGFSAAEVRALGDFPDYAELSGVPLPEPYHEFDIGKALARPYRPFRWSYHQTMSLTKLETDWWIELENTYRERIAQRKELYAKHGSSVLGYLPGSELACKELMEMVLQFICARYPQYFVIEDNRILHNKILGTKQDLKSKHPLDILIDNVPEDFGIMLRDEKTGFYFLRAGVICSSLGWNVGTKIGLQLHEIHETIPDYKEKMQFSMDRFFTKMPVDKPIQRGSWGLEVGQPLYMPKGDPHETLRLSQDPNLQLEDCNLRVDWQTLRRLPLSAAVVFNFKALFTPVTEFRDEPGVPALTAKVLKEGKKNLMDYKGTWHVEHVVIPNLEKWAAEQEESGLVPKDWQVATLDDSPWFKGWQEKWHRQQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF66</accession>
    <name>A0A317XF66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_571222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472429.1">
        <property type="nucleotide sequence ID" value="XM_025614861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF66"/>
    <dbReference type="STRING" id="1450535.A0A317XF66"/>
    <dbReference type="GeneID" id="37117004"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF35">
        <property type="entry name" value="PROTEIN O-GLUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="5">
        <location>
            <begin position="689"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY95668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="995" mass="112272" checksum="3675DB6525CDD7F7" modified="2018-10-10" version="1">MVHFSAETGLKASVGVFLLSCTFLSTSYNTTFAFDHPLNSAALACFLAGTSLLILSRFIHRIPKIPSSAPKYSAIPLTERDPPLEEPFSPVSLSSNSSLTLTRPRNSARWIKRGLLSVLGGLRIALYRDITANIECAPDGYAYSIPFFVALYDYWRNQRSRPTPIWTTLEDPQNAHLRAIVTFVSRVHSFLFRSRWRYVIPAFFLLTSGYITTTFGDGMQSTYICPITSGQSARLHAFKVLAVIFDSLILIGAAELASEGVRSGDNRRKHSLVSWAYSLLGVAVFYTIIVIALTASSYDENGFPSAQYLHSAVGQGVLVTCVIVSASQLIPYYGISGLAVLAGFISLYFTWASTLFNGQHPFPLILASRAFAALFFSFLGGLSFLYARTASEEEPQFLYRFNIAMRLIFALLSAIGLILVAQQHSAAHLHPIDLLVYEGRQHHDQWFARANSSQGLADAVMKYRAQYNQHPPPNFDKWYEYAVSRSSLVIDEFDQIYTDLLPFRALPPAQIRELTQKLATNPYNEIGAISIRNGKARVQEGIKPTHAWMVISAAKMIEKFSEYLPDMDLAFNLNDEPRVSVPWEKISVLRHQAKSSGVPPEDSIQTGWSADRGDQWGPIEPADQTKETLFVDNSFKNIFDRYVGSICPPSSTARSQRIWDRRHLCLSCIRPHSLGGFPSDWTAATDICHQPDLTSLHGFLLSPASFKVAQDLTPVFSQSTIAGFNDIIFPSPWNYVDKIEYKPSPENPDANYTEKTNTLFWIGSTSEGTSQHGEWKGMPRQRLAHLVNNNTFNKVSVFLPTNETDTYHYEILDGRVPSDTLHLDTTVNVIDPIVRCRQKDCDDQRKELSPGSRVDFQSHWQHRYLFDSDGAGFSGRFLPFMQSHSLPFKTGLFRQWFDSRITPWLHFVPIDLRLHGLWSTLAYFAGVDSTVSVDGVSRRVTIPPHDIEGEWIAEEGRQWAQQALRKEDMEIYFFRLLLEWGRLTDDQRDLLGYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGS0</accession>
    <name>A0A317XGS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_591731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472941.1">
        <property type="nucleotide sequence ID" value="XM_025616128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGS0"/>
    <dbReference type="STRING" id="1450535.A0A317XGS0"/>
    <dbReference type="GeneID" id="37118271"/>
    <dbReference type="OrthoDB" id="2107166at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LysM" evidence="1">
        <location>
            <begin position="47"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="206" mass="23014" checksum="CB635E7A445CE7F5" modified="2018-10-10" version="1" fragment="single">SPLIHFSLSQSQDHVFPHHLLSLSRYPHHHHINIPNLHPTTLHTTIGLHTVTPNDTIASISNLHSRGICDIARLNRMADATLPLLTGEKLLIPPETCTPDNSTCLILPNPSGTYADCVSGGPHAYYTLEGDTIRYIALKLNITVAALSATAQGVSPTQMPLCKWVIFSKSRSVVPVGARLSRCCLRTARIRIWRRRWERPWDRLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UQK7</accession>
    <name>A0A317UQK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_540947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000081">
        <property type="protein sequence ID" value="PWY64283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461271.1">
        <property type="nucleotide sequence ID" value="XM_025613023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UQK7"/>
    <dbReference type="STRING" id="1450535.A0A317UQK7"/>
    <dbReference type="GeneID" id="37115166"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="4"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY64283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="269" mass="29427" checksum="6A7DE2DB37C36497" modified="2018-10-10" version="1">MSGYDRALSVFSPDGHVFQVEYAMEAVKRGTCAVGVKGKDVVVIGCEKRSALKLQDTRITPSKIAVVDNHAVLAFAGLNADARILIDKARLEAQSHRLTVEDPVTIEYITKYIAGVQQRYTQSGGVRPFGISTLVVGFDPNDKTPRLYQTEPSGIYSAWKANAIGRSSKTVREFLERNHQADMDREQTIQLTIKSLLEVVQTGAKNIEVAIMSPGQTIEMLPDDQIESYVKNIETEKQEEAAKKKTGRGGTTTAAILTRPGGGEGESRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UW26</accession>
    <name>A0A317UW26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_561520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000057">
        <property type="protein sequence ID" value="PWY65619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461455.1">
        <property type="nucleotide sequence ID" value="XM_025614224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UW26"/>
    <dbReference type="STRING" id="1450535.A0A317UW26"/>
    <dbReference type="GeneID" id="37116367"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY65619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="546" mass="60871" checksum="CEA6F0E69A95D03B" modified="2018-10-10" version="1">MTDPRIVIGLDFGTTYSGVAWALSDSPNETEVITSWPGSGNKTTPKVPSTMTVKCGGRLQWGYQTSFFGNHIRGVKLLLDKSQDPEYVASLESAGFIKKNWRSPVTYAGRYLEQLVLHTKNVLQKRFGPAVQSMEMQYVLTVPAIWSDKAKDATMRAALKAGIPHQDISLVSEPEAAALHCMTVIRPNTIRDGDVVVVCDAGGGTVDLISYCVKTVSPLCLEELVEGTGGICGSMMLDVGFTKFLDSLIDKKKVPDKAREMALRFWQDNIKPNFASDPNFLEETHFVPLPGVKDNSKIGLRDGFLQMDGTQVKAIFDPIVDQVQDLIEGQAARAKESGKSVKTILLVGGFGASDYLYQCVQKAHSGIIVMQPPNSGAVRHGTEGNKVGKRIARRHYGVRFRTDHKKTLKKYPKSAHKWCDLTERWYVHHMTEWYIHKGAEILENTPVRFHFCRTIPCDGTPVFEDKLYVCGDNVAPKRLNERVFSVCTLKSDLRAIPTRLFKEKSNSKGMQYYCIEHDLVMTPRSGSIDFELQFNGASYGHVEATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXJ7</accession>
    <name>A0A317UXJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_479746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461569.1">
        <property type="nucleotide sequence ID" value="XM_025608760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXJ7"/>
    <dbReference type="GeneID" id="37110903"/>
    <dbReference type="OrthoDB" id="10313608at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="49" mass="5050" checksum="AAE01589279F78DF" modified="2018-10-10" version="1" fragment="single">GFNERFSGDGVEPPRNRAVFDEDASAGARKAAPGMGGCVPSVRRAANNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYV7</accession>
    <name>A0A317UYV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Annexin ANXC4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_308421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461897.1">
        <property type="nucleotide sequence ID" value="XM_025606808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYV7"/>
    <dbReference type="STRING" id="1450535.A0A317UYV7"/>
    <dbReference type="GeneID" id="37108951"/>
    <dbReference type="OrthoDB" id="2134400at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF107">
        <property type="entry name" value="ANNEXIN ANXC4 (AFU_ORTHOLOGUE AFUA_3G07020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="880" mass="97712" checksum="C942D386021E9122" modified="2018-10-10" version="1">MSLHVGDPRSRGRSKSPSGHIRERSKSRDPRLPTGQDTHRYLASEFVDGKRHSRSRSRGASPGGPNPPGSRYGPTGPEFQSDGRAPYLRVQQGRDYYYQSDSGDSKGARRDNKQYPPPPHRRSVHYDSYSDHSYSDSDEDGLAYGDLPGEPVRSFYGITGTSRPQSAGRDGAMMSGALNGDASYSNKSSRPNGPSKEEITDNHPGYARPEPFQYTHVQPGSSQYSGHPASSTVPSNWEPIPECEKPGFVPPTSQGQSQTMPGAFPLPTTSHPDVPATTAAAAFSSTRYVTPEGLQNPYASWNSRPLSMPGSNVYTPVTSTHQRTASSDAAVKAPYAAPPPYQYAHIDPNLKFTSKSAGETPAKPLSYSAAPQYSTKTGASQAKEPQYVGIKHSANPQFSKTSSTRPDSGPQYVEIMPGNRATSRPHSHSVSSANNLSVARPDPTHRPASPMLEPYKGTYQTISPMPSPIVVVPKLDEDISDIEPLGDESDGGLREHRRKKFRDGKDRKGLTTDHVKRESSRVRYEQRGSTGSESLVVISPSSSRKRVSFYDAGQDAMALQEALSHTLHTDNKALIRVLPHLTGEEVLELRKEYKKHVKLHGKGVNIAKHIRLKLGNGAFGKVCYATALGRWESEAFWANCYYQSSTSRRELLIESLFGRTNSEIREIKECFRDSRYQNSLEKCMKAELKADKFRLAVLIALEERRQSERDIIDMNLVDHDVEELHRALITPHGGETAMICIIVRRSDSHLREVLRAYKKMYGHNFVTAMMGKSQNLVGETLAHILNGAINRPMRDALLLHQALRESRTGKERSELLISRLVRLHWEPRHLERVKSDFRRRYGQRLEDAIAEEVLTSSGGSEWGEFCIELARGSKVLASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZJ5</accession>
    <name>A0A317UZJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_339271</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000058">
        <property type="protein sequence ID" value="PWY65360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461426.1">
        <property type="nucleotide sequence ID" value="XM_025607023.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317UZJ5"/>
    <dbReference type="GeneID" id="37109166"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000664">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000377">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000119">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000139">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="742"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1178"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="1543"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="133"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="503"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="702"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="927"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="997"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1257"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1309"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1682"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1732"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1944"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2019"/>
            <end position="2047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="154"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="930"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="953"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1265"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1310"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1350"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1360"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1402"/>
            <end position="1419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1465"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1688"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1736"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1797"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1818"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1867"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1897"/>
            <end position="1907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1949"/>
            <end position="1959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY65360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2047" mass="223882" checksum="759381FF5A146F85" modified="2018-10-10" version="1">MAGNGTDDIQYLAPPAVTALRQEARSVDPRFSPSRSSSVDNIREEREDLKEAAEQTLNVIVDLDLDGRVKWVSPSWKQVVGTSPESIEGQMISEIVVGNKNVFHDAIESMKEDDSRSRFIRFAVQMGPESVLKYSPEPRPAAETEAETTGTAEVAKHQEDLPEKEKENRHHDILHLEGQGIMVFDRTADGVGHTMWMLRPFTEPREVTIDLPPLLVESLGVGAEVLANYLTTLAEAAASEPDPSKHPAPNPVLCRICERQITPWWFEKHSDLCLQEHRAEMDVQIAQENLNEHRHAIVKVLDALEARQSRPLVLGDTNPPPSPQPEYKGLPIGPSPAASAPSSGSVSSSNSAPGTPPRSRDHSASGIGHARARSFAVRRPLARVVELILDLCDTASEINMPVIRETRAESGDDFRTLSPQSESRISQVIQWQSPSSNTLEQEQGIAALCTDTEQVAKAKVDAVIRHRRIVEYAERIRIEYTILVEECITAALSKAERIAAGQLSDSTASDDDALPEPEPPVVANSPIIHGKRESVPPPPMSALTMSMRNSPDRFHSNHSSEGKSSVAVSTGSNSPMECPTPRSHKSIAGVLGTSQPSRRGISMLDFDAGDNSDSSAPSSAFPGAVRTDSPSSDRSLDRKRRSLVLPGLSSSPRRQHSPARISGPHSPLRMPRARLSSGADSLPSPIVSPSSNAIELAQLHYPHHRRQSSATSSDLVKPPVSPHLSSASQPQPRPAPPSIKDFEIIKPISKGAFGSVYLAKKKVTSEYFAIKVLKKADMVAKNQVTNVKAERAIMMWQGESDFVAKLYWTFSSKDYLYLVMEYLNGGDCASLVKILGGLPEDWAKKYIAEVVLGVEHLHGRGIVHRDLKPDNLLIDQTGHLKLTDFGLSRMGLVGRQKRVLKSMNEPAPDLLKQGSFPRATSIASSRSASFDFQGSGSPGSTPLITPDVAGSIPQPSYFNLNQSGLSRQTSRRASGYRSDSGASESLNAMFRTLGLHEGGEASGTMPVPVPSSGHHLPEEESQSEAGESPHLYPLQPTLSNSFSYSTPPQQSMMPPLMALFDPDDHNRRFVGTPDYLAPETINGVGQDEMSDWWSLGCIMFEFLFGYPPFNAATPDEVFDNILHRRINWPDEPEELASPEAIDLMNKLMAMHPRERIGANVDERYPNGGAEIRSHPWFSDVNWDTLLEDKAQFVPNIENPEDTEYFDARGATLQAFTEELEDASPPPQPLTVGAYPQDRPHDALFKVRSQVNSMKRPLMPLHIPPHVRESRSRRLSEPAMADDFGSFSFKNLPMLEKANKDVIQKLRQEAMQAQQRHVPPGSQQPGHAQGQDPAPSQPAPSLEGSPLPMSLQRTLSQTKGSNRPSSPSSMSQANSSPSRPSQPSSPLLVQFSTGQNHERRKTSGSSSNNSQSTGNTQPTSIDTGRMASLKFGSASSSPIKPTRATAHSPDKTPSGPRHGSAPASRARSQTIGSQDGDLSSSLAKESYVAGHYKRRSQLFDISPSSSDNEDPRTKALLKVQRRRQSSRRLSQINFPEGPFFRPLDVLICEDHPVSRIVMERLFEKLRCRTITAVNGTEAMRYALSEVQFDIIMTEFKLPQVTGADVARMVRETRSANRHTPIIAVTGYLKDLPETHHFDALIEKPPTLTKFTEALCKFCQWKPPPKDYNPSQPFPVPPTIRQAPVQVEHSPSSTTSSSFALVPSSSYRGSSREDSIVSSYFGDMESIKPEEGPVIVSHHNDEPEPDRGGLGISEDATPAQEPADGGSTFASDAVPFPSLLHATSAPATLHQPLTPRKQRSSEAIRAKRESLERKRYECAESGDDEDEELGNSPTRTSSPRQRSRRPGSKLGIEMMRTNSRGSVVSGSEELLKRERESLERRSSGGSDRVSDGGEERPGSRSPLSPSLRSRFGDLNIPEEAIAGSVEGYSPKHSPTLELGLNSDFPAIFSERPSSPNFTETSAAPGMEASTQTPKLGHITPPIVFSRDGDVDPAGQDPDSCIKMPGDDFISEFGAEADIDQYLDADATPRPLHTPSPNPYLDAFPSPSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0K3</accession>
    <name>A0A317V0K3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Utp8 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_528053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461934.1">
        <property type="nucleotide sequence ID" value="XM_025610407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0K3"/>
    <dbReference type="STRING" id="1450535.A0A317V0K3"/>
    <dbReference type="GeneID" id="37112550"/>
    <dbReference type="OrthoDB" id="5330858at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018843">
        <property type="entry name" value="Utp8_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10395">
        <property type="entry name" value="Utp8_b_propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Utp8 beta-propeller" evidence="2">
        <location>
            <begin position="26"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY67585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="912" mass="98952" checksum="AD6B472EC3E9AF66" modified="2018-10-10" version="1">MDLQPPSVLAHLPRPLHASTGKTHLGEVHSLADSKKRKRHEVVVAVDGEAVNIYNIQTPKLVTSYAVPPQSSFSCQPCSVRRKIPNKSVVRRQTYVAVKQQIKSFVEENGGNVASAPSIASSSYSVKDSESPAVFVGIVPTESQGDEEEESFDVLAVHQDGRVRRLSSDLKTQHWSLRHSEVAKTNATHEIRSCFLVEFEDAKKSLFKRRQDLAALAFSNLTESGVDEPSVLLLVSHPTGSEQTKLSDVKVQMFSVPANASQGHDESQKMRHLLTVNMPDVEGQEAIESRGSQWYFHAGSAGLNLSFGRGYINFDLSQYTPTVTSKFILENEEFSSVMRISPQSVIGAGKSMIAVYDTQYKSVQRSIAVGDVPASASSGVKARTTFVSYYAKLGVAIATKDNTLLAFDLSPSHNAAGTSLKRSRDGLLIDAIGRGIGSSATQWDPATKKHRTEHTAALGLTSPEQVERWNQLTAELRQCAASKNTDGFDRAVQAYFGSKGLPSPDTYVNPETTVFLLSLIFSLKDDAESHDQLSASSAFRVSVDLWPQQTCQWLIQIGHMSVNNVEIALRRSFKPRILPSLPTGSFVQGLTDSDPSLQRLIDVLQGRVLFSTDELAYILKFLINTARARSISLDEEVPKALTNGEDQDTNTTQALTISTPAEASLANIFLALNTTLQKIHLHPLPAITSSIRSALSRTEIISMVHHLRLSLATGGYTSRFTESPPIPVPAEQTNPPLSLSTIIDLLNASVDAIGPSGWISATAGLDDSPARDQELIADMKSEISAALAGVEEATYLKGILNEYLRYATSASRSAPTAVTIDSGSDTPASAMVRCEKLNGADLMVFGATENDEGFEGDASGKLLPLSLKADSNDVSKTKVKLSTGEVKTRSSREIGYLRRKAAGKYSFERLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2G1</accession>
    <name>A0A317V2G1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_590917</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461862.1">
        <property type="nucleotide sequence ID" value="XM_025616071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2G1"/>
    <dbReference type="STRING" id="1450535.A0A317V2G1"/>
    <dbReference type="GeneID" id="37118214"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="175"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY67218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="687" mass="76276" checksum="4134247C8BEC3026" modified="2018-10-10" version="1">MAFQGSKLRREMRQLYAWAFSCTSTLFPALARASTDPSSNDLTVFFHNNGNWSTHGTRPSALFVNVPVSYSQAVSICEAYNETLLGCEDFDDHTYELSYQQYLGVIDQNQTFWSSCSSSCPVDWQGTVSKPSSTSAFVCTNSAPFVSVVDTDSSKFPTVSVESNGTVFEGLRDHMAFRFIGIPFAKPPTGALRFRYAEDWSASYVDATRYSAGCLQYGWFDGNAYGLNPWGNSEDCLYLNVYSSSLPAANSSAPLKPVMLWYHGGGQTTGTGTDSTFDGASLVSRSDVVLVVPNYRLNIFGYLTTGDDIIPGNYALTDKLSALRWVQKHISDFGGDPNNVTIFGQSAGGGSVIDVLTSPYGEGLFNGVILQSAGRGHDTAPDVAAATNVPVLNKYCNNTGYERLQCLQELPAETLLNLTYSELTSWKTIVDQIYVPDISWAQLAKGQPYISRNIKYLSGHMPEEAQSLLETVLNPNVTSWKENLEILLNNSQITPKQAEAIVTSGQWQIEGYSSNYTSDLAKTFSDVYNASINVATDAQSVLLMSNGSMLYIGGYALSYYDYYDLCTFPVGRPETPYYRCYSSDLYEVFGTYYLFDQPIRVDEDVYYTNAVQDMWASFARTGNPNVNQEYLKTRGYNSTLEFFENWSWPEYTTYSPEIANLQYPPLAQSMLPDLAHCKVLLPYTTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3B1</accession>
    <name>A0A317V3B1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_540249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462238.1">
        <property type="nucleotide sequence ID" value="XM_025612875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3B1"/>
    <dbReference type="GeneID" id="37115018"/>
    <dbReference type="OrthoDB" id="509124at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY68575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="24927" checksum="C996E107433964C8" modified="2018-10-10" version="1">MATGSPSSKASLAANPTPNIAAADAVLHIEGIALIDAPLRDVWDTLLDTSTWPSWNKFAPAVTIRQQPDSDAMQVVSPVLQEGTKLTFHVNMNPASSQPQPRQDVPLIVTEWHPPTSDKKLGRIVWVMDATVQGRIMASLLNAERVHELSEVEIQDADGQMRRMTEVRTWEAQIGTLAYVVRWMYKARLAECFDLWVQNLKEYVELGRLVPHLESYIFNIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4K8</accession>
    <name>A0A317V4K8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_590700</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462242.1">
        <property type="nucleotide sequence ID" value="XM_025616051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4K8"/>
    <dbReference type="STRING" id="1450535.A0A317V4K8"/>
    <dbReference type="GeneID" id="37118194"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="17">
        <location>
            <begin position="91"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="176"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="390"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY68579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="491" mass="55011" checksum="F516A434477ECAA9" modified="2018-10-10" version="1">MSTVRFSSALARRTPLTAPLSSSARRFLSSSSSISSSSSSVSTRSPRSLTSASSLLSTRPASARWTGLSSLNLTQSRTMATEIPKIKVKNPVVELDGDEMTRIIWQEIREKLILPYLDIDLKYYDLGLEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKQMWLSPNGTIRNILNGTVFREPIIIPRIPRLVPGWNKPIVIGRHAFGDQYRAKDRVIPGPGKLQLVYTPEGGQPETIDVYDFQGGGVAQTQYNTDESIRGFAHASFQMALLKSLPLYMSTKNTILKKYDGRFKDIFQEIYETTYQKDFEAKNIWYEHRLIDDMVAQMIKSEGGFVMALKNYDGDVQSDIVAQGFGSLGLMTSTLATPSGDAFESEAAHGTVTRHYREHQKGRETSTNPIASIFAWTRGLIQRGKLDETPEVVSFAEELERACIDVVNEEGIMTKDLALACGRKDREAWVTTREYMAAVERRLKSNLKARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6A5</accession>
    <name>A0A317V6A5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_477640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462572.1">
        <property type="nucleotide sequence ID" value="XM_025608649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6A5"/>
    <dbReference type="GeneID" id="37110792"/>
    <dbReference type="OrthoDB" id="4497058at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="468" mass="54450" checksum="FBEF497FB659DA23" modified="2018-10-10" version="1">MIPEIPDEPEPAPEPAPVDKVIEIEVHGIKAKFHLNRSDEELIPTRHLAKADHTRIVQRPVWAFRKEDDARLKNLKKWSKVDIAFRGVFQTLKKGPQFEKGLFEDENGSAAICPPRTNFKKVCKRQAQVIYALLDELMYKLAISRESEDDRKWFYLRPRFMDCRAEYWTGYRHKYKDGPFSASWITLDHFPDIGVARCVVPVSTTTEENQPLQAALAGKLQLIMGQLLINILRLHPPGDQIPDQEVFLIGLHGCKLYLLRAIFPGAKTSKLWCGRHNPTVFHEEQKRSIASTVSKRFYSRDNMARFMEQLNWLHLARSLSEEDPDPHVFQVLGSQEYDLWTKDGFRAARRLLAGLNMYLMSAQSKVGVLQEIFALFPYDESAEVEVDDGEAVVQSVQKEQNEVLEEEKRLEEEERAKKEEELRHVRTTEAIRSTDRDRIAGFRDIRRPWWDWVWEDKRDEGRSGRARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6G5</accession>
    <name>A0A317V6G5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_590409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462453.1">
        <property type="nucleotide sequence ID" value="XM_025616024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6G5"/>
    <dbReference type="GeneID" id="37118167"/>
    <dbReference type="OrthoDB" id="5368615at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY69625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="187" mass="20527" checksum="53FD61BE1FDB9BB6" modified="2018-10-10" version="1">MSQQQSLLVSYKREYPTRVIIVPMNAVQSADLNQMVAIGTRDLGGCSTVVIASKTGAILAHLPPRPSMDLSDPFTGDSNVRRLMTQVVDLYHAHRDKYFATITDTVIVCAFHEGEIALQDQVQIMTTKLQGLGPEIYTYQVPVQHGIPGRGTVAVVGSQGFVTLGLPDRPRPLILVEDMVYVPRHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7C5</accession>
    <name>A0A317V7C5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_579172</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462376.1">
        <property type="nucleotide sequence ID" value="XM_025615251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7C5"/>
    <dbReference type="STRING" id="1450535.A0A317V7C5"/>
    <dbReference type="GeneID" id="37117394"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="382"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="224"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY69171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="617" mass="67324" checksum="9C1838FC40AEE45D" modified="2018-10-10" version="1">MPYCNNAQEDQVASTCSPPQFPGDDTRPTSRKELVGWYSYGWAAEVFAVCAMGSFLPITLEQMARERGVLLSDKTTPCSATWSALQSTSVSEPQDQLSYVTAYMKSGVPKSSQCIVHILGVEVNTASFAMYTFSVSVLVQAILIISMSGAADHGSYRKLLLVTFALIGSVSTMLFLAVVPRLYILGGLFAIIANTCFGASFVLLNSFLPLLVRHHPLLVREHSDEDPLARTNDNHSPTADVPSHNEDSETTALLQPEQSHHGSSPDDATQLFVQRTSQELKLSTKLSSNGIGIGYIGAVILQAICILVVIETHQTTFSLRLVLFLIGLWWFIFTVPAAIWLSPRPGPPLPQRKKRGTWVSYMAYAWESLGRTAMRTRRLRDIMLFLAAWFLLSDGIATVSGTAVLFAKTQLDMQPAALGLINVIAMIAGVLGAFSWSLVSRIFNLHASQTIIACIVLFELVPLYGLLGFIPAIKRLGYLGLQQPWEMYPLGVVYGLVMGGLSSYCRSFFGELIPPGYEAAFYALYAITDKGSSVFGPAIVGIVTDRYGEIRPAFVFLAVLILLPLPLMLLVDVERGKRDALSLAKELGGKQSLEVAPDYGTVSNCLSRGEDILAQIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V878</accession>
    <name>A0A317V878_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_297752</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462402.1">
        <property type="nucleotide sequence ID" value="XM_025606720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V878"/>
    <dbReference type="STRING" id="1450535.A0A317V878"/>
    <dbReference type="GeneID" id="37108863"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="52"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="508"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY69197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="558" mass="61063" checksum="4CB6946D02381896" modified="2018-10-10" version="1">MADKVGVYIPQYASYNWTGAPSDYEALTTNEIGGNSRTENLNKWFQSGDQAYIIVASAMVMVMVPGLAFLYSGLARRKSALSMIWACMASFSVVTFQWYFWGYSLAFSPTATNGYIGNLRNFGLMKTLADPSPGSPLIPNLLYAFYQMQFCGVTAAIIMGAVAERGRMLPAMVFVFIWATIVYCPLACWAWNVNGWAYKYGVLDYAGGGPVEIGSGLSALAYSMVLGRRQERMMLNFRPHNVSLILLGTVFLWFGWLGFNGGSAFGANLRATMACWNSNLTGAFAGITWVLLDWRLARKWSMVGWCSGTISGLVAATPASGFIPPWASVILGVVTGIVCNYSTKVKYWIRIDDSMDVFAEHGVAGIVGLFFNALFADDAIVGLDGVNTGSKSGGWLIHNYKQLYIQIAYIVATCAYAFTMSAIIAYAINAIPGLKLRASEEAELLGMDDDQLGEFAYDYVEVRRDYLAWTPQQHNQLEDGHQIPAAARYGIGEHSEMMLDGHAPVGVDSRGCSEGDSGIQELKMQPAPRQVAEHHAPHEPEPIEEPVPATQINEKVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9W8</accession>
    <name>A0A317V9W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_560670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462526.1">
        <property type="nucleotide sequence ID" value="XM_025614174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9W8"/>
    <dbReference type="STRING" id="1450535.A0A317V9W8"/>
    <dbReference type="GeneID" id="37116317"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF15">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE (AYR1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY69828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="286" mass="31533" checksum="0003263D66003627" modified="2018-10-10" version="1">MATIEDKRRSVLITGCSPDGIGNSLARGFHRNGLRVFAIAREAKTIEDLASIGIETSVRQCFAEVNAKLGEKGLDYLVINAGRNYTVPAIETELSEVRATFETNLFAIISICKTFLPLLMRAKGTIVQIGSVAGIVPYVFGSVYNASKAALHSFRDSLCVKAAPFGVTVTTVVTGGVQSRIARIQRTLAPNSIYAPIGDEYNRRVTHSQDGAMPNAAYARSVVTQVLYGSAPCRWISPWAQGWKSWIWEGNKSWVIWLFMGGWAWSGLTESIVTKMFKLHRLRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VAR2</accession>
    <name>A0A317VAR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_526840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462642.1">
        <property type="nucleotide sequence ID" value="XM_025610366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VAR2"/>
    <dbReference type="STRING" id="1450535.A0A317VAR2"/>
    <dbReference type="GeneID" id="37112509"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY70351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="86" mass="9640" checksum="87F78B94F17E61DE" modified="2018-10-10" version="1">MKQAQLEDQIYRFEQSYLEETTAGNIIKGFDNYIKGSSSGGGGATRRKATVTDADRVFSRSSAGFMRVCSPFSSLLVSFVVIWMRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCN1</accession>
    <name>A0A317VCN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_539979</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462468.1">
        <property type="nucleotide sequence ID" value="XM_025612812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCN1"/>
    <dbReference type="STRING" id="1450535.A0A317VCN1"/>
    <dbReference type="GeneID" id="37114955"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF0">
        <property type="entry name" value="FI21273P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="3"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY69640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="452" mass="50460" checksum="BCFF32D73DC38D15" modified="2018-10-10" version="1">MNQFRVITRWRPLASSDVHQTEINRNCEEHPNSRISMSLVPSAPNTRPWKSEAAFTQVFEARDNNKTVFDAVVAPTLPEVLKGHCSNFFAYGHSGSGKSHTIMGYDFNNPHEFGMCLAAGHHLFEKLEALNEADSDAALQLGIGLRMYELRNKTAFDLLNGRCNCHVREGYDGQTHIRGETEVLENGKVRVRPIVTKACWSFDELRRELLTGLALRATGSSTIHDQSSRTHAVLELEIVTRALLDARDAVIERQSELVPVAKRATDIYLEENLKGVVQTPDGEYIPSPDYQIDQARIDAAEAQKAEFETFVKEAEHHVEEIMTSSQHRCLGGKLVFVDLAGSEYYHDKAAPSIPRPKQTAQEQQEGRQINTDLLSLKEVIRAKAHKQTRIPFRSSPLTMVLRAHFMGSRTVKSHSAMILTVSPSAEQFAATMNTLKYGNLIGVAGSDKKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFB1</accession>
    <name>A0A317VFB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Purine-cytosine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_627863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463102.1">
        <property type="nucleotide sequence ID" value="XM_025617445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFB1"/>
    <dbReference type="STRING" id="1450535.A0A317VFB1"/>
    <dbReference type="GeneID" id="37119588"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY72149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="52522" checksum="6C798CBC9030C3F0" modified="2018-10-10" version="1">MNQEKQDIITQESAKEQNAPGQAWMYRALSIETGGIERITDDDRQDNTTRFWNAATFWFSANMAVATLNIGALGGSYGLGFWESFIVILLVNLIGDILPAWTATFGLSGLRMTTFSRYSFGHWGNLIVVIFSMISTTGWNAINAISGASVLSALSNGKFPTWAGVIVICTVVYIICVLGIHWIHRLDTFLWIPFLVVWCVAAGTGASHFTTAVPHGNEYSSSDKAASVLTYMATIFSFPISWINCAADYNVRMPAGTPRWKIFSATYVGIFVPTVLVQTLGLPSWKAAYEDSSIGGLLGMALSPAGGFGKFLMVLAGLSAVPNNIPNNYSFALHAQNLTPRAARVPRIVWITFGFVVSLIIGCCAAEYFKDVLQTFFSVIGYWTIIHVTVVLEEHVVYRRGWKGYNLDAWNDPTQLPFGWAAIGAFAGGVVGAVLGMKVAWYVGPVAALIGKSGANIGQAMTLGISGVLFLCLRGMERRYCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFD1</accession>
    <name>A0A317VFD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_627987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463043.1">
        <property type="nucleotide sequence ID" value="XM_025617452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFD1"/>
    <dbReference type="STRING" id="1450535.A0A317VFD1"/>
    <dbReference type="GeneID" id="37119595"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016447556" evidence="4">
        <location>
            <begin position="22"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="131"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="305"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY71807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="466" mass="50649" checksum="548351947467FB05" modified="2018-10-10" version="1">MKSTLLYSLPWASALLPAIYGAPTGGNPPLRGSEDLLGYSASNTVTDQTTDDIPYVPVPGQTEAADVGVYLDFEDAENLPQPVRGDVGGTDPGPRNLYYDKINSDKLAPPGTDNGQTINAQWPMGLSHNRLGLNESGWARQENEVVMPAATEMAGVDMRLEAGAYRELHWHVASEWSLVLNGSCRIEAVNENGQTFVDDVSAGDVWFFPPGVPHSIQALDTGVEFLLIFDDGSFSEDNTFLATEVFAHQPRSVLAKNFDLPIAAFDDIPEDELYIFPGTPAPTNIEEQNVTGSAGILPRSQSYSYHFSEQPAHEVQGGSVKIVDSQTFPISTNTAAALVTVRPGGMREIHWHPTSDEWTFFISGKARATLFTAPSTATTFDYRPGDVGYFPQSNSHYIENTGDEDLVFLEVLQTDEFTDVALGQWIGSTPKQIVADTLHLPQSALDKLKTEKMYVVAGSNVSDVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFH4</accession>
    <name>A0A317VFH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_525086</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463401.1">
        <property type="nucleotide sequence ID" value="XM_025610297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFH4"/>
    <dbReference type="STRING" id="1450535.A0A317VFH4"/>
    <dbReference type="GeneID" id="37112440"/>
    <dbReference type="OrthoDB" id="8954335at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056073">
        <property type="entry name" value="DUF7656"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058519">
        <property type="entry name" value="DUF8206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056072">
        <property type="entry name" value="SNTX_MACPF/CDC-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32046:SF11">
        <property type="entry name" value="IMMUNE-ASSOCIATED NUCLEOTIDE-BINDING PROTEIN 10-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24676">
        <property type="entry name" value="DUF7656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26633">
        <property type="entry name" value="DUF8206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24674">
        <property type="entry name" value="MACPF_SNTX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SNTX MACPF/CDC-like" evidence="2">
        <location>
            <begin position="6"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7656" evidence="3">
        <location>
            <begin position="384"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8206" evidence="4">
        <location>
            <begin position="919"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1049"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY73136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1185" mass="134917" checksum="C4680064B3FDE2D8" modified="2018-10-10" version="1">MADLKRLALGVTVSLGTLYDARTDAFISLSLFNDTPPPEAIKVIDHHHSEVKFGQSESYRKKFENMNMSADLSASFLVGMVQVNGSGSYLNNTLISKKLTESSLFYNITTRAETVSLTHESLRGMYAFNEIDSSLATHFVVGIVYGSNSIVTCRSTNTEHGDSTKNQVRLRTALEKLWSMTVDETADTSSIDDEEESELEFSVFGDALIDDVVLPQNFRGTLHFMKNVPRYIQNTNGGKGKPIVYRLLPIGALEYMGTGVEIIGNGQLHAVSRDYMERFVELFDEIEDIKRVLNDYKVFVYCHRHCVPDQHLRQVIYNQREIRCRQDCLKSAYSELLRTVRGGTESPEKLSALHACLLEGNDAIVRLADVTNEYRDKIDFIDTLVGNGARYIRGHDPFLDTEVAWAGDEDVFAFYFTESSRKNCEYWTSLFAVLEEIVRSECPRASVLLVDEEGGDPPRSNPIIVHYRHGITIVPDVYQERKLFGEKCLMRYNPEKLERTAMNRPVGRRLVKTPCPGPYCSQNEVLEWICRGCQALAQYGHTDSYIYCDCGRTTYTEFEFRCNSPRHGGAYAKYDPTKFKQYMDQVEPLPELNVLILGETGVGKSTFINAFLNYLLYETLDDALDAESLNWLIPCSFSTQNSSPDDPRGEIIETKVEVGMSDDEHSALDGQSATQTTAIYPFQLGDVTVRLIDTPGIGDTRGVEHDKKNMANILAVLSNFDKIHGIVVLLKPNASRLTTVFRFCIKELLTHLHRDASQNMVFGFTNTRGSNYRPGDTFTPLKILLAEYRDFGLGLYKHTVYCFDSESFRYLAAYKQGINLGNRVQYTESWKQSADESQRLLNYFQTLTPHQVKSTMSLNDMRRTISQLTKPMADIMKAINASIDLNKDQAQELSRRELSHKELTGKLWVKKISVALATVQRPRTVCGHRDCIEYRQIPNSHQNTIYRSICHDPCNLSGINADAVGFPGLRDCAAFGEDRSRCLKCNHHWQQHLHILYEQRERTDTVVDPDIERDINNNKATIDTKQKAIKNLEVIIQEYESEYEQIKKAAADFSIFLQKHSIATYNDAMIEYLDLLIKREKDIVNVGGNDDNLQRLERSQAEYRALIQTLETLIRDGDGQTVLSREQVVARVGELYALKHYGAVLRQAVEVVDTAHMNTFREKPYRPLPGGRSRLQKFWARVWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHC7</accession>
    <name>A0A317VHC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_538806</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463516.1">
        <property type="nucleotide sequence ID" value="XM_025612565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHC7"/>
    <dbReference type="STRING" id="1450535.A0A317VHC7"/>
    <dbReference type="GeneID" id="37114708"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10004">
        <property type="entry name" value="RPD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="11">
        <location>
            <begin position="38"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY73764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="682" mass="74895" checksum="7AB4D779E038E5A1" modified="2018-10-10" version="1">MTSLAPLDPITNGSADRNKKVAYFYDSDVGNYAYVSGHPMKPHRIRMAHSLVMNYGLYKKMEIYRAKPASKYEMTQFHTDEYIDFLSKVTPDNMDSFAKEQSKYNVGDDCPVFDGLFEFCGISAGGSMEGAARLNRNKCDIAVNWAGGLHHAKKSEASGFCYVNDIVLGILELLRFKQRVLYVDIDVHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGELRDIGVGQGKYYAVNFPLRDGIDDISYKSIFEPVIKSVMEWYRPEAVVLQCGGDSLSGDRLGCFNLSMRGHANCVNFVKSFNLPTMILGGGGYTMRNVARTWAFETGILVGDTLTADLPYNDYYEYFAPDYELDVRPSNMDNANTKEYLDKIRTQVVENLKRTAFAPSVQMTDVPREPLVEGMDDEADAILDDLDEDENKDKRFTKRRFDQYIEKPGELSDSEDEDEAAANGVRRQPGVLKRRNQVNYRNLDVNDSGLESGMATPQDASSIPDDDMDATGDAKMTEAPEPETEAQGTPSAAEAPSRAEDASATEQTEMAVDGQEPAAPSAPISRQPSPKPQDEDTPMVDAGEDTPQPEKSEAVAEGQSEEEKKPSEEIPAADKSAPESSSAAKDPSPPKETSESAEAAETGAVKPAEPSETSETKGKTPEASKDESGATTTEQRPSAEATGHGQTEASKSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHR7</accession>
    <name>A0A317VHR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Endoplasmic reticulum-based factor for assembly of V-ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_438285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463615.1">
        <property type="nucleotide sequence ID" value="XM_025607497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHR7"/>
    <dbReference type="GeneID" id="37109640"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY73863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32241" checksum="745CDAEEB728759E" modified="2018-10-10" version="1" fragment="single">MVLLITTPPILSAIEALPTSSRNDLDLPEALDLNDPISHAQIIQIARYFRAQTPADTTRGRSLDALLRGTKVYIPPPPKKPEPSPEYLALKARLLAAAETDAYNRMTSSTLTPFTTSRSAPAPNSIFTSSTPTVSALHDKTNNLSDKREDEDPLTPSLVLNIFLSVLITGFSVYWALSSFRTPELLIETVAGVWGGGGRGGGKGVSEAVKVLVSLGSALGVGVAEVMIYAIYLRKIELARGKERRMKERKVVVESEKVGGTKGDTGGDSVDGGDKEEIWGRGVNGGLRRRVREKWEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJ48</accession>
    <name>A0A317VJ48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Retinol dehydrogenase 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_539101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463482.1">
        <property type="nucleotide sequence ID" value="XM_025612628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJ48"/>
    <dbReference type="STRING" id="1450535.A0A317VJ48"/>
    <dbReference type="GeneID" id="37114771"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY73217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="304" mass="33319" checksum="2B16514414BC9E5C" modified="2018-10-10" version="1">MAFDVATIKSRATQGAFFKRQLFGEPPVVSPTDVDLSGKTAIVTGSNTGLGFECSKQLLDLGLSRLIIAVRSEAKGEEAKKELLAGRRSGKAIIEVWKLDLSRYDSVLAFVERTKSLDRLDIVVNNAGVSKRIFEIIKSTGHEETVQVNHLSNALLTILLIPVLKEKNSPEHPGHLTVVSSDTPAWAKFKEKNFTPLMSAFDKRENFDDQDRYPTSKLLGQLFLRELAKRVPPSVVVINAPNPGLCKSGLVREFRGTLVGYIFSIMELILARKPSVGARALTDAAVKHGAESHGQYIEDGKLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLZ3</accession>
    <name>A0A317VLZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maleylacetoacetate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_538939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463644.1">
        <property type="nucleotide sequence ID" value="XM_025612590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLZ3"/>
    <dbReference type="STRING" id="1450535.A0A317VLZ3"/>
    <dbReference type="GeneID" id="37114733"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016034">
        <property type="term" value="F:maleylacetoacetate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42673:SF4">
        <property type="entry name" value="MALEYLACETOACETATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="62"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY73892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="193" mass="21852" checksum="8A77F3DCD0601FA6" modified="2018-10-10" version="1">MGTRAHHEQKYKDELNPSASIPTLVVHHPDGEKTIIRQSMTILEYFDERFPDRSPLLPPVSAWQDRIKVRDLVNIIAIDVQPPTNSRIAKRVRAVQDNVQDQIAFVRQAFTDGFQAYEALISPSSKYSFGEQVTMADVVLVPTVDQALMYKMTLDFAPNVLRVYNSLKELEAFKAGDGKNQGDTPEQFRSTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNT2</accession>
    <name>A0A317VNT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_474531</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463705.1">
        <property type="nucleotide sequence ID" value="XM_025608518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNT2"/>
    <dbReference type="STRING" id="1450535.A0A317VNT2"/>
    <dbReference type="GeneID" id="37110661"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY74512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="781" mass="87257" checksum="678BD14B442EF86B" modified="2018-10-10" version="1">MSARDTEPPTPPPPKKVRIACRRCRAKRVKCDGGTPACSNCSRASVPCVDVDGQNRDIFIPRNFITQCCARIRWLEQQIQILDPEFDLTKGPSVNGTQVDMSSQSSPGIPNNNPPSMSETQPQNHDKPITGKRTYDSVEGLELDRPLPAEASSVANVLGMLSLHSDSRQQHYMGSSSGLLFTKLIGAGRETQETSHISHTETTYGERSSASQISMTAYHSLYWTLAKELPAPEEAGILLGIYFQHIHIDQPFLHPASLANAYWALHESTKMERPGKHDSNGWMEGIRPFEYNGKIDVVEGKESTPISVFTAAFHVFMVFSLAATVLTRKKNFDHSPTRFYRLAIAEASDCFSSVSVTALQGILLLAVHSMACPAGLNIWTLSHIAMSHCIDLGLHREPDPSSASKTSLAINRLIFYTVYSLDRSISTIQGRPLGIRDETFDIRCPKLDDITDELLGIANRNMNISTPSTAHMSLSIRRFQLDQYISEIKLLFYHLPKELRPLVWPGDLKGLQARIKLDLDAWLTETSVILPPAKWEGDTLRFQHEKLKLETLYHSAITLLFQPSQVFRSPSQSALQQCYQSNRRKIRIYNHLNTEDQVYYSWRNIHGIFSAGATMVYCIWACPALQAAIPFAEVLWDLRTCSNLLSIGGQWWPSVRNGKGSFDQIVDLTIRRLSRSQPPSPRTRRRLEPPSTDISGQPDITRTNLDTDIFDRGMQVVGETSSYPMGLGDLLSMEDPGLLPPDTTYLDASDTAAIDSAMESFLAEFVHGDWSWDPFAGSTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNV3</accession>
    <name>A0A317VNV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_228732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463725.1">
        <property type="nucleotide sequence ID" value="XM_025606289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNV3"/>
    <dbReference type="GeneID" id="37108432"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="162" mass="16835" checksum="97790E4ED6FC433F" modified="2018-10-10" version="1">MGVVEALGLVEGGSDAHFLSDTRAAMGIAGAGNGRMAGNTLLPGDPAREATDEIITIIMPMPTATVISPVTILMSRLVLVLLLLVVVRIDQQCLNQPTRKGGIRRIRGSRAVSRTAAASSNNQSSMDRRSDAGGVDGLIIAAPRSDCVQIRRTVDGATMLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPI1</accession>
    <name>A0A317VPI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_538802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463512.1">
        <property type="nucleotide sequence ID" value="XM_025612562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPI1"/>
    <dbReference type="STRING" id="1450535.A0A317VPI1"/>
    <dbReference type="GeneID" id="37114705"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000050">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="33"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY73760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="698" mass="78519" checksum="AE5A1F447F59B5BF" modified="2018-10-10" version="1">MPPITAPTTSSQKLASPGFNAGARPYRSHKVRACDLCRKRKSRCTVDIPGQSCLLCRVQGADCHYQEEANNDPPLTNGHEPKPWVADHARVSSLGQKRKHSPDTDSPSHSSRRRASSVAHSDSALDRRRSDSRSQGVEDPHNESVLIVGPVVAEDAQVIERYMPPERTSRSVEPKSQPYNVYSSDPRKPILYTTVSRRRQGMRVGVPPGENQKEILEQILGPFKRDLVRLFIDRFNAAFPIFDGETFWEAFLSESPGDPPASLLCQVYSMSLVYWKHTPKLACHPKPDPRYAVNMTVAALHEEFSAPGLSTVSAALIDLTGRPIFSMTGNAISCGRMISLAHCLGLNRDPSHWKLSRPEKNHRMRLWWGVVIHDRWGSFGHGVPPQIAKNQYDVPLPTIDVLIPQTSRTPERVRAAHCHIALCRLTEILGDLLPLVYGLQHRAHRETTKKVRQIRTDLDVWEDSLPDWLRNPISTNPSEDRISGTSSLQLGFLAVKMLVSRVELNEVNNAEADNPEARRYFQTECRRSAEEIVQFISSLRKQNFQEFWLPYSAFHLTTTATLLVRCALETTDPEVARSCLTNVETFRSILRRVREEEDWDVADMCLDHCERLLNRLNSTTGANNNNNSSEHPPTFTNLGHQPDSLVNPAAISLPETQTNNDIVDDMMSISGTFGTMDGFPFDMTGIWDVSVFQDVNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPX6</accession>
    <name>A0A317VPX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_499295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY75985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463982.1">
        <property type="nucleotide sequence ID" value="XM_025609367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPX6"/>
    <dbReference type="GeneID" id="37111510"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39614:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="33"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY75985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="347" mass="37572" checksum="5DDDE98A101FFFAC" modified="2018-10-10" version="1">MAAPYAITPTDRSGVIVITATLFMSWMLLVSLFRVYMRVAMNGPPGWDDAVAWIGGAIGIGNVCAIMKSVSHGLGRADPSDGEDAIKALYTAEILFLASHCAAKMSVCLLLRRLGRERVYLRLCIISLTILASWAVASILAVALQCEPAHSWELTGCRSFVVGWRAITAFDVVTEALLVGLSIRLVWGVQMRRAQKATVIGAFGTRLLIIVLVLWRQCYLNQVGFEHFLLGISDVVVATEVLLHCSLMAATVPCLKPFVIAFNTGWGQGGQKEGSYLRSATSGGTPSQPRSHLRSADDEITMLPPEGTRGRANPGEGANGLVIHETREWSLQTEYIEMRPLKGSGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQK9</accession>
    <name>A0A317VQK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_627316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463954.1">
        <property type="nucleotide sequence ID" value="XM_025617409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQK9"/>
    <dbReference type="STRING" id="1450535.A0A317VQK9"/>
    <dbReference type="GeneID" id="37119552"/>
    <dbReference type="OrthoDB" id="5295362at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY75327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="374" mass="41799" checksum="BC97D6E3864ADC51" modified="2018-10-10" version="1">MVVTSCDERGPPCSNCISRELKCTYFNIPGARKEASPPAAIPAPMQSPSKVAPSQTATYASLPLSRNGPSPLKFASLRELELMHKFSTETYQSLCNEPTDHHVWQSVIPRKALEYDFLMSGVLAVASLHIASEREPPEALSYIDTALEFHDLAFAPFRHAIDNLTPANCDAVFAHSVLTTVIGIALPQLAATREDSQSMTENIIVVFELLHGTSNIFSISRPWLQDKLFTSRRGFWETQLSILDSETEAALDRLTALNNDMLAGANVEQHRVIKNAVSLLRRCFCRYDHNRDVASILAWVATVDKEFVHALRCRQPLALLVLIHWGALLYELDGKVWWATNSGRALVSELLRALRPCDVRWEGALQWPKRKIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRV8</accession>
    <name>A0A317VRV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_499366</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464028.1">
        <property type="nucleotide sequence ID" value="XM_025609373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRV8"/>
    <dbReference type="STRING" id="1450535.A0A317VRV8"/>
    <dbReference type="GeneID" id="37111516"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000011">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000017">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF92">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="12">
        <location>
            <begin position="238"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY76031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="667" mass="75192" checksum="2F367BA03F36FC80" modified="2018-10-10" version="1">MAATPHPFDPITPAEIVLATKILEAAFPGIPLRYKKIDIQEPIKSDVVPYIEAERLGKPLPPKPARLLQVLFHRKDTGAFFKALLNAGTRSILSAKQLPKHIQGPADMDELAEVEELCLSHPAIQAEVAKLQLPPGVTICNDPWIYGTDDPNEARRLFQCYMYIIATDHPQNNHYSVPCKFSPVFDIIKRELVRIDYLPGGADAQTTETQPWKPVETVQYAHDLLQEPLRTDLKPYIVQQPEGPSFGVQGNVVEWQKWRFRVGFNSREGLVIYNLTYDGRNVFYRLSVSEMTVPYGDPRAPYHRKQAFDVGDVGFGITANQLSLGCDCLGHIKYFDGYRADSKGTPVLLQNIICLHEQDNGLQHKHTNYRNNAATVVRNRQLVVQMICTVANYEYIFAFIFDQAANIELEVRATGILSTVPFDNEKFGTTVPWGTNVGPGVMAPFHQHMFSFRMDPALDGFKNTVYYEDSVPLPEDENNPYLVGYTTEQTVLRTSGTANTDVSRHRVFKIRNDAHINPITYKPVAYKLQTSPAQMMLASPKSYGSKRAGFATKPIWITKYQDDELYAAGEFTNQSKQSEGVEKWVQREDPVENEDLVLWHTFGLTHNPRIEDFPVMPVERVSVMLKPDGFFTKNPALDVPPSSQSFNKSTLHPEPVACCAGEMKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSZ7</accession>
    <name>A0A317VSZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_605321</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Diels-Alderase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464059.1">
        <property type="nucleotide sequence ID" value="XM_025616481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSZ7"/>
    <dbReference type="STRING" id="1450535.A0A317VSZ7"/>
    <dbReference type="GeneID" id="37118624"/>
    <dbReference type="OrthoDB" id="5344254at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054499">
        <property type="entry name" value="DA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056402">
        <property type="entry name" value="DA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22903">
        <property type="entry name" value="DA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24137">
        <property type="entry name" value="DA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159245">
        <property type="entry name" value="AttH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016367714" evidence="3">
        <location>
            <begin position="23"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase N-terminal" evidence="5">
        <location>
            <begin position="83"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Diels-Alderase C-terminal" evidence="4">
        <location>
            <begin position="257"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY76062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="414" mass="45749" checksum="3EAD163FA273DE91" modified="2018-10-10" version="1">MLQVLKYFYLFTLAHAVGLVQGWESTFPQNWPLNWTPQPELNLAGQDSCTTSHLTAYETAGSGADIWLSTSPLDDFESPKILPLNSSSGEQWEFDGVSDDGMNAFIFGLYRDPGLSLMGTGNLRISAELAYANGTRWGRVDYASESTVESCPHGTKGVWRGTDFSYIFEISKDMSRVKLEVDTPDLKGIIYMRSKTLPRYADASTWPAENASTAIAPHFHWVEPIPVGDVKVDLFAKGEPFTWHGLGGHNRLWSPFNWFTCLKAMNAVRMTAGPYSLSYMRFTSRIAGGKDFTSVLLMHGAEKIFSTTLGEASDVDDYVLMSKTYDGAVTGTLRDKVTGYELELVSPGRKKHWTFIMEHKNIAFEYLVGKGRGGSGFSSSSSGGPVGLEQFRGVALTEALTFPDSSPLFKNQYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTL3</accession>
    <name>A0A317VTL3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_195698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464452.1">
        <property type="nucleotide sequence ID" value="XM_025606063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTL3"/>
    <dbReference type="STRING" id="1450535.A0A317VTL3"/>
    <dbReference type="GeneID" id="37108206"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="2"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY77265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="109" mass="12417" checksum="B56DD77BE7807FFA" modified="2018-10-10" version="1">MITHIVQFQFKSSTSPDKVQETCAHFSSLKDNCLHPTTQQPYVKSFKAGKQDSPEGMHNSITHVFVMEFESNEDRDYYLTKDPAHLGFVKTLDGLIEKSQVVDFTEGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VV20</accession>
    <name>A0A317VV20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_522729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464665.1">
        <property type="nucleotide sequence ID" value="XM_025610191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VV20"/>
    <dbReference type="STRING" id="1450535.A0A317VV20"/>
    <dbReference type="GeneID" id="37112334"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="189" mass="21466" checksum="9B32DA57D9CFE317" modified="2018-10-10" version="1">MSSATKASRIGEETRVDKVNAELVTLTYGTIVAQLCQDYDGNYQEVNKQLEKMGYNIGMRLIEDFLAKSNVGRCANFRETADMISKVGFRIFLNITPTVTNWTSDNNQFSLIFDENPLADFVELPDDGRAQDELWFSNILCGVLRGALEMVQMQIEAHFVSDVLRGDDTTEMRVSLVRYIEDEMPPDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWC8</accession>
    <name>A0A317VWC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_538070</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464395.1">
        <property type="nucleotide sequence ID" value="XM_025612413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWC8"/>
    <dbReference type="STRING" id="1450535.A0A317VWC8"/>
    <dbReference type="GeneID" id="37114556"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000395">
        <property type="entry name" value="Putative Peroxisome biosynthesis protein (Peroxin-10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="324"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY77208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="375" mass="42224" checksum="A32FA43C74657DAF" modified="2018-10-10" version="1">MADEDLSLAPSAPTPSVSTSAHFYPFATSPDIIRSHEKDVFLTGSLTSQVHSIVRSLRGARYAHTHSDAIKHLTEILYFSLTTLVGNRTLGEEYCDLVQLEDDTLQLPSLPRRAGYILSTILLPWALQRILPAFRQRLRSKLERSIARQQLKAAQIKGMVERAKNNSSKKQSFFTKLRIQKYILEHLDSITSLSPVYALSIATFYFTGAYYHLSKRFWGLRYVFTKKLEDSEQRVGYEVLGVLLVLQIAVQGILHIKKVGADLQQEDQNNGLEVGGASQYGDAVLPSLEHPSSLPLLPASSARYDFSEDSNAIPWIPTGQQRKCTLCLELFKDPSVTTCGHVFCWTCVRDWVREKPECPLCRQEVLLSKVLPLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWD1</accession>
    <name>A0A317VWD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter Fmp42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_537870</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464597.1">
        <property type="nucleotide sequence ID" value="XM_025612369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWD1"/>
    <dbReference type="STRING" id="1450535.A0A317VWD1"/>
    <dbReference type="GeneID" id="37114512"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="680" mass="74553" checksum="49C47354B3967166" modified="2018-10-10" version="1">MSLNRVSYLESWEQNPAAFRRQPRPEDSEDEDGYHDLPETSLSSSFQSTISRRSFRQRLNFNPYAGPGWSEVSGDEADRHTLLRAASPRRSRADEVETEQPPENHVALKTQDYESLETTGAFEVERTKRILQVCIAVIYCFFAAGIVFGFAAIKPVLIKEGVYRNQCSQEELESGSDVCYGQELRLNLMFTIAAVATNVSALPVGTILDTYGPRACGVIGSICLTLGSLLFGLAPKLPVDAYLPGYLFLSLGGPFVFIPSFHLSNTFPARSGLILSTLTGAFDASSALFLIFRVVNEKTDGVFTSSRFFLLYLIVPIFILVAQLTIMPTTSYKTAGELVREVQAHIAAEATDQIDEGLNDRHESERQRNDRRLHRQTVINQIEDLLSAEQHQQPQPEPEPAKPTNPHTAGGVWGALHGLSALRQIRTPWFILITLFTILQMLRINYFVATIRQQYTYLLDSPALAQTLNSTFDVFLPLGGLISVPFIGTILDNASTPFVLGTLVTTATLIGILGCIPSMIAGYANIVLFVIYRPFYYTSVSDYAAKVFGFQTFGKVYGLIICLAGFGNFAQAGLDALTFRVFDRNPTPINAFLTGTTFLVGVVMVVYVFWEAGKMAAASKANENGVDATIAENGLSVPRLHDGIDSRDWALGREGERAPLLQAAGGGRHGDASSYGISGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZW5</accession>
    <name>A0A317VZW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_537667</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464787.1">
        <property type="nucleotide sequence ID" value="XM_025612320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZW5"/>
    <dbReference type="STRING" id="1450535.A0A317VZW5"/>
    <dbReference type="GeneID" id="37114463"/>
    <dbReference type="OrthoDB" id="2862635at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070007">
        <property type="term" value="F:glutamic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13426">
        <property type="entry name" value="Peptidase_G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.700">
        <property type="entry name" value="Peptidase G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000250">
        <property type="entry name" value="Peptidase_G1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038656">
        <property type="entry name" value="Peptidase_G1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536:SF1">
        <property type="entry name" value="ASPERGILLOPEPSIN, PUTAITVE (AFU_ORTHOLOGUE AFUA_7G01200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37536">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01828">
        <property type="entry name" value="Peptidase_A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00977">
        <property type="entry name" value="SCYTLDPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016403510" evidence="3">
        <location>
            <begin position="20"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="18"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY78478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="318" mass="32878" checksum="51FBA1A986386B3D" modified="2018-10-10" version="1">MKFTSSLALTALLAAPALAGPHGHKISESRNDGSQDNFPGAPSDNQGFNGQAQPSFGGYQPQGQQTQSQAQPTAQASTASQVAPAVTSSASHSSSSSSSSDDYYVNENWAGAIQETSGTATFSYVAATFTLPSVTPTAASSDDTQSASFWVGIDGATGQNQIWQAGVDIYVENGETSFLGWYEWYPADTVSFDMDFSIGDVIVASVESTSSSEGVAILENLTTGKNVTATASAPSTSATLVGQTAEWILEDLSVDGDGLTLIDFGEAYFTGCVAKAGGKTVNLDGAELYAVEDSTSDHVQAAPTIVSNTELKVTYESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W032</accession>
    <name>A0A317W032_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UvrD-helicase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_182603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464876.1">
        <property type="nucleotide sequence ID" value="XM_025605982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W032"/>
    <dbReference type="STRING" id="1450535.A0A317W032"/>
    <dbReference type="GeneID" id="37108125"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY78567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="175" mass="19453" checksum="F429A99A221734D7" modified="2018-10-10" version="1">MDPILDGLNYAQTSAVASPASILQVLAPPGSGKTKTLTARVAYLLAHHGYRPQDVICCTFTIKASREMRERLTKLIGDELQRKLVLGTFHSICRRYLVTYGYLIGLKKGFGIADSGDSLATIKVSVYIHLLLYVRTDFCRGSLNDCRSESSPTQPGQEYPIRKLTGLARMRWLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2N9</accession>
    <name>A0A317W2N9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_626076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465124.1">
        <property type="nucleotide sequence ID" value="XM_025617332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2N9"/>
    <dbReference type="STRING" id="1450535.A0A317W2N9"/>
    <dbReference type="GeneID" id="37119475"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38895" checksum="E6C2B57F52C8544D" modified="2018-10-10" version="1">MDIVHASNTALVQNQPLVAVFFGGTSGIGHYTLRALATAESKGGKGFRAYIVGRNAKAAEEIIEECRDICPQGHMKFVQTDDISLIQEVDRTCAEIIQLEEKANQNPRIDYMMLSQGGSIFLPRKDTKEGIDVTMSLMYYSRMRAIMKLLPLLLKSPLPAKVVSVYAAGFEGKLFPDDLSLRDLKHYSYSQARSHMIYMHTLFMETLAEQHQGNLSLIHIFPGLVLGPGFDRPDLPAWFRVLWRWVFVPFLAPLVTVPPTECGNRMLSLASPRYPPRAVESSGTQQEAAVGTDGKQGSGVYSLSRKGETNYNKKAYRKIDKDEMRQKVWDHTVKAFEVIEAGKVFTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2T6</accession>
    <name>A0A317W2T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome b561</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_521162</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465174.1">
        <property type="nucleotide sequence ID" value="XM_025610136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2T6"/>
    <dbReference type="STRING" id="1450535.A0A317W2T6"/>
    <dbReference type="GeneID" id="37112279"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="40"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY80315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="241" mass="25956" checksum="0BC6A167DCD68E3B" modified="2018-10-10" version="1">MASVTGIPQEHPDTIQEREDAPLLATPGNVPQKESAAIYQNLFTGTASAAQVGIWMLAILVWTGILTHPLIFFSSHPLLNSAALLLQVQAALILQPTTTPHQKRLGTIIHYVIQTISLLAFITAFIIIEINKGDHARFTSPHGVLGLITYIIIILQALGGVVQYLVPVQVLGSVDRGKSLYKYHRKSGYVLLLLELATVAAATQTTYNLNVLAIPLWGVLVAAALVVVGVGARIKKHKLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W351</accession>
    <name>A0A317W351_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pheromone-dependent cell cycle arrest protein Far11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_537085</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465535.1">
        <property type="nucleotide sequence ID" value="XM_025612190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W351"/>
    <dbReference type="STRING" id="1450535.A0A317W351"/>
    <dbReference type="GeneID" id="37114333"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="125"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="561"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="800"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY80933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1064" mass="118968" checksum="22996CB7C60ABBDC" modified="2018-10-10" version="1">MDDASEPADNAMQEHHIVKADEVDQTGTDISPVSDDQLMEEVAEGLRQEQSQQSQQNTSAAPEEVPVETRRGSKRPELRRDAAAPPPPLQPPPPAPVQQNAERPPDSLSLAQLRLLVQEMPKVEQPAYAFEYADSQPFAEEVEEWFQYSEFDRVMLIGMKSSFQLRWNSFCDDQPADVSPQSWLATSYDLRKTFMSQLINTLEDRAVLVRIEALEALCYTLTGVWGATAGRVVDDLSEGGSQPGAEIPESQSLQIKWIEQNVALVHECSGLQPLVTCLCRVFERHRQSSAVDSESAGQEGVNSAYIAALEREANLVLTALYLAVEVGRKQDAVDPQKAPLRDTLMGLEPNLLVFLVEIIARLRWDDSANVPLTRVILLFWKTLLLFFGGSNKLKEAKELLEPSLKARENASPRRTPFLTASPLDYHNFRQEITSKYPAYNPPPPVVPLELENNSILPPLPQHPSRVGSSNGPFSGVGPSVTGGSGSIIHHPVHIATPAPSPPPSPIGPGGKAGKKQNYQTNQNFPFMYPPLDDSSNDLGGKGTTELQDALVGQKWQGSDVPASIIEAGRLFSTHVKMTRAMRQLWEERERFMKYDRGWYADDGHPFSAENPVSGLADELQDLNFPERESSVDSSPERETDNADIQRRLDAVESFYRQALVHLQSITIVFLKIILTNVSAMVNQAAQAMGDGYGSVNGFPANHPNGHIDLNSEAAIDELDNIRLREITGKAISGSLLLLVKWFKRSHILKFEYMTQLLLDSNYLPLILKMFAHQDVDQAVAQKNDREELGFFRFCHLHSNQPPESTTDLDEDSSPSDDEAVPPPITRHRQDTDTSVRGVLPDVSIPEFVEGPHRPEVDELGYPTAPPPKEPITVFSFRNFFSAINYLHIMQKITRDKAHRCLLLVQYKSSTILRKGLKIPDPHLRFYTLKLFKSQVPYCGRKWRQSNMRVITAIYLYCRPELRDDWLSGGDIDSEVEEALPLEQALRGLTHWWHLRRYKDVMGGEEGASLMEEERDFFVRELEAMGWGVAGEESFGGSEEAEMGAGGPMVNGTEWDGAPLQMEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4I8</accession>
    <name>A0A317W4I8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7136 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_557985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465604.1">
        <property type="nucleotide sequence ID" value="XM_025613966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4I8"/>
    <dbReference type="STRING" id="1450535.A0A317W4I8"/>
    <dbReference type="GeneID" id="37116109"/>
    <dbReference type="OrthoDB" id="4490227at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055560">
        <property type="entry name" value="DUF7136"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23584">
        <property type="entry name" value="DUF7136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016344640" description="DUF7136 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7136" evidence="2">
        <location>
            <begin position="20"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY81536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="261" mass="29179" checksum="6F12C529EE2D61AE" modified="2018-10-10" version="1">MHFPQARWLGLLGVMVTVTTADTVEVDLIFPHNESYAPADWFPIVFVVQNTQSAELLNLRISYDIRWNNDVNNQSIFAHDFRWTNWSGSADPYLAYHYLRWQSCDEEYLSRPSIYYGRNGIFNHHYSGWQFFSIEDAPLKDVDLVAATANATCPGDCNAIAINVTDITMNTFWNMNTAGRDTCVVTTNSTASHTYSTPDPCRIAIDADSAASMASVHHTRLCDGLNPPDDCPKRENGAQKLEAWGMSCFLAAFGVTGAMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4V7</accession>
    <name>A0A317W4V7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_147484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465724.1">
        <property type="nucleotide sequence ID" value="XM_025605771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4V7"/>
    <dbReference type="GeneID" id="37107914"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY81656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="282" mass="31831" checksum="318BB2663E494221" modified="2018-10-10" version="1">MKQTQVHLIYFYCSFQLGASQSLQNLLGALLAQLSYALPEISADLKTCFERRSPPTPDSLIQLLLKYGSRVQKLYIIVDAINESDEADDILKSLMAILEASENVYVMTTCTSPPSTQCKVRYLKETMKPSSNKYDIQAFVNLQLELQPALRRLPSQTKVHISNLLSSKADGMFRYVRCQIDLLSAQKTGRGVLRALEVMPEDLNGTYEVILGRVSTHDRDLAREALLWLTFSRQALTLPALNEALVLEKGDKYIDDEYRLINPDIVLEICQGLVVLTRLTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5J1</accession>
    <name>A0A317W5J1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_587624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465483.1">
        <property type="nucleotide sequence ID" value="XM_025615842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5J1"/>
    <dbReference type="STRING" id="1450535.A0A317W5J1"/>
    <dbReference type="GeneID" id="37117985"/>
    <dbReference type="OrthoDB" id="4338954at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="94" mass="10905" checksum="98ED032D189A7534" modified="2018-10-10" version="1">MNLSASSTGSQRPLIKRPALTPAFKKPSRWYLPLMGAIALGFGVVNYYQDQAKHYHYDREEEERLRKNRALMDAYGEKETVQDIERALVVYDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6A0</accession>
    <name>A0A317W6A0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_602190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465434.1">
        <property type="nucleotide sequence ID" value="XM_025616412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6A0"/>
    <dbReference type="STRING" id="1450535.A0A317W6A0"/>
    <dbReference type="GeneID" id="37118555"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14724">
        <property type="entry name" value="ZIP_Gal4-like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY80832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="870" mass="95643" checksum="2F021644138BA0E5" modified="2018-10-10" version="1">MSVPGKVEYRVRCSKLGTFFGADQCCSSKKFPYSLLLLCWKDTISISSQLRSSRGLQCSAKNTAPAWESRLSPGFPAGQVTAARGPPLRDKQFHLVDSSPAGPNVITAPILVAGRCIGMHTNAPLSDEGGGRTSESHPPYKRVRTQVSRACERCRIRRIKCDSERPCKPCLQRSDPCDPGGEDELKTFPQALREVDRLRQRVKELEAELSLHKDRLALNTPIVSTASSSPGPSAFEPRSTPATMLEGREGGHLGPVQEQPQQSIPNTQPHKSWGGINVVAANPANQAWYGPSSLFYFIDRMARFLSINLHQNHSAEQMSLYGSTRALLGDPPGNSKLQPGDNTQASTTIASPQKFLSLTQEEYFLDLYWSSYHTALAPILNEAEFRQHYRSLWIASGNTRQPSALADIVVAVSMQLGMSMLPPAKQKEMGPVDASMAGQWYFQRCRTLLAYELESPTLATVQALLLSAIYLCSAAFHNMSDNVAGQAARAACALGLHHDPPDTLPQPERELRRRLWWALVILDTKIGLKLGRPLQFYHTESSPALPDDQLLSAMGAGSDYSPLGDTVTWLSFNLHNTKLFLVARSAQTTFYGKGLALHDGQSAWDNQLVLESLAESLHPFVQSLQQWVSEIPDALKLNRENDGSAFSTDGSKLEIELFAPAWVQRQRFHLELTYHYICFCLFRPLISYSSVSAPTAVYLAEKSALHGIALTNITHQALTTTSVLAGWHEAFQWQWSAAITLVGFVLAYPHAACITAAKQAIDTSIAVFEIFGESFVIGTKAANTMRSLVAAIDLLRRRQATAGVHMPNDIQPLVPDELGSGIDGFMSSETFDFDAISSEQMQDIFQVALSIDQWSYFDALWASGNGLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6A7</accession>
    <name>A0A317W6A7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_536881</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465697.1">
        <property type="nucleotide sequence ID" value="XM_025612137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6A7"/>
    <dbReference type="STRING" id="1450535.A0A317W6A7"/>
    <dbReference type="GeneID" id="37114280"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY81629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="440" mass="50519" checksum="9FFBF9D98C18A8AE" modified="2018-10-10" version="1">MPTTIAQTIQSYALRLVQDTLRQIAAPVKLIYVVDGVKSVLYNDPAIQDADKAVIYVTHVNFWRKVLLDFDLGFAEAFMLQEVECDQLSKVFDLYIKNRATLDSGDSLFHLAQRLAQWWRPANNIDNARINIASHYDTSNGLFTNFLSADMNYSCAHWSNDTAESLQTAQRRKVHYMIRKARVQHDHHLLDVGCGWGDLIIEAAQLTGCRATGLTLSEEQKNLTDERIRDAGLQDRVRVLLCDYRNAPRPGNGYDCIISIGMFEHVGPEYMDQYFEVISQLLKSQNGVMVIDGITKIHPFHETNPRVGDYINRYVFPGGYLPTPSILFEALHRGSKGTLEVSSVLNTGPHYGKTLLAWRNNFISNWEHIRSDFSPRYPDASEKEIETYRRRWLYYFEYCEAGFRNRILGNYTICAVRTPEVTIDYKSLDIDDAQSIKLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6S6</accession>
    <name>A0A317W6S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_626051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465564.1">
        <property type="nucleotide sequence ID" value="XM_025617329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6S6"/>
    <dbReference type="STRING" id="1450535.A0A317W6S6"/>
    <dbReference type="GeneID" id="37119472"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="145"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY80962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="217" mass="25437" checksum="37805C0ADCF547F1" modified="2018-10-10" version="1">MSSNVGLSTPRGSGTSGYVQRNFAFMKPRNAGYGAPYPPVSGANNFSPADRPFKQRQPDKQILEHDRRRAIEVKVMEERERLEELNEEIELREKEGKKTQKEKEVKEEEEDEKEDGEKDKDVERVLTEEEIDERCEVLRAKLVKEMEEEEKEKERGAKNGDAGRRRPWGRDLPPKERRQFKSYQVHELAEAKIEESERLRRALGIREDRETGELGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBF3</accession>
    <name>A0A317WBF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_567061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465936.1">
        <property type="nucleotide sequence ID" value="XM_025614605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBF3"/>
    <dbReference type="STRING" id="1450535.A0A317WBF3"/>
    <dbReference type="GeneID" id="37116748"/>
    <dbReference type="OrthoDB" id="5426165at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40623:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="243" mass="27459" checksum="CF1FEA0CA125AD1F" modified="2018-10-10" version="1">MQFWVGWALWQKLSFTKKYATAEARQRAETQPMLAEPSEIPFGARALEKGIQVEGIWTPDCHSARESTTHSESRPISIASAPKQLSMMPPGDSIQGPERTYQPVSIPNLFDPRSPSKVLDIEHGRPGDIYASQITQSPQLDARGNAGGEDFPELEKHRSRGWFGTRSSWVKKPFESYKRRSAHEGHRRTSSESFRRRISKLIDENIRTNPDEIYQLRAINQEAAEGRRTASLTRSPGPTYAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBU2</accession>
    <name>A0A317WBU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_599208</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466291.1">
        <property type="nucleotide sequence ID" value="XM_025616302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBU2"/>
    <dbReference type="STRING" id="1450535.A0A317WBU2"/>
    <dbReference type="GeneID" id="37118445"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000074">
        <property type="entry name" value="Enoyl-CoA hydratase (AFU_orthologue AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF152">
        <property type="entry name" value="ENOYL-COA HYDRATASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G03410)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="272" mass="29398" checksum="48E7B7740A219C60" modified="2018-10-10" version="1">MSLRSLAIQHPHFLVSFPHERVVQVTLNRPEKLNCIDLSTNREIQKVWELFDQDESLWVGIITGAGRAFCTGADLQEWNAMNQAGVVNDMSPPGLAGLPRRSGKKPIIAAVNGICMGGGFEMVANCDIVIASSSAIFALPEVKRGIVPVAGCLPRLTRTLGLQRTMDLTLTGRSVDAKTLHEWGLITRLVEAGNDIAQAAVEIAAIMCGNSPDALIVGREGIRLSWESGSVEDAVSTLAAQSYPRLVEGANFAEGIRAFVEKRPPRWSNSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WC60</accession>
    <name>A0A317WC60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_536481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466277.1">
        <property type="nucleotide sequence ID" value="XM_025612028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WC60"/>
    <dbReference type="STRING" id="1450535.A0A317WC60"/>
    <dbReference type="GeneID" id="37114171"/>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="60" mass="6967" checksum="C7F2BADA683050A4" modified="2018-10-10" version="1">MAKKAKSRTISVRLISMAMTGYFRTMIRPRTHRPLSMLKYDPVVKKKVLFLEATKGGRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCZ2</accession>
    <name>A0A317WCZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_117713</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465857.1">
        <property type="nucleotide sequence ID" value="XM_025605549.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WCZ2"/>
    <dbReference type="GeneID" id="37107692"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="653"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="764"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1182"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1214"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1253"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1296"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1326"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1356"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1450"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="151"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="845"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY83072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1513" mass="168931" checksum="03FFD6C11784BCF6" modified="2018-10-10" version="1">MAQRDGVGSSQPSSSKQEEVEAAEGNPQRPLRIEREDSSFFDAMEPEQKAELTRLASNFPRRQSTLDPGVDGGIERKDTLEGLEIGDPVLDPTSDQFDHYKWVRMVLKMLDREGIPRPPSTGVVFQHLNVCGSGSALQYQNNVSSILLAPFRPQEYLPCVQHTPEKHILRDFDGLLRSGELLIVLGRPGSGCSTFLKSLCGELHGLKLRKSSEIQFNGISMEKMHREFKGEVLYNQEVDKHFPHLTVGQTLEFAAAARAPETRLQGISRQQYAKYITQVVMTIFGLSHTHNTKVGDDYIRGVSGGERKRVSIAEMAVSGAPVGAWDNSTRGLDSASALEFVKALRVSSNLGGKCHAVAIYQASQAIYDVFDKAIVLYEGREIYFGPCSEAKEYFVNMGWYCPPRQTTGDFLTSVTNPQERQAREGMENKVPRTPDDFERYWKTSSQYARLQQEIEQHLKEFPLGGQHEQRFGEMKRLKQANHVWQKSPYIISIPMQVKLCTIRAYQRIWNDKPSTLTNVIGRIAMSLIIGSMYYGTPNATAGFQSKGAALFFAVLMNALISITEINSLYDQRPIIEKQASYAFVHPFTEAFGGVVSDIPVKFVSAVVFNIIFYFLAGLRYEPSQFFIFFLFTFLSTLAMSGIFRTLAASTKTLAQAMAMAGVIVLAIVIYTGFVIPTPQMSAIPWFSWIRWINPIYYTFEALIANEFHGRRFTCSQFIPGYPSLSGDSFICSVRGSVAGERSVSGDAYIQTQYSYTYAHEWRNLGILIGFWIFFTALYLVATEVNSATSSKAEFLVFRRGHVPPQMRNLDKQPGGDAGTTDVALAHRAAEAEKDTSALPKQSSIFTWRNVCYDIPVKGGQRRLLDNVSGWVKPGTLTALMGVSGAGKTTLLDVLAKRVSVGVVTGDMLVDGRALDSSFQRKTGYVQQQDLHLSTTTVREALRFSALLRQPKSVSTREKHEYVEEVIEMLNMQDFASAIVGTPGEGLNVEQRKLLTIGVELAAKPALLIFLDEPTSGLDSQSSWAICSFLRKLADHGQAVLSTIHQPSALLFQQFDRLLFLAKGGRTVYFGDIGDQSRTLLDYFQANGARACGPSENPAEYMLEIIGAGASGRATKDWPGVWNDSQQARDIQTAIDKIHQERASNPDTGDDNAQKGEYAMPFPSQLWHVTHRVFQQYWREPSYVWAKLILATASSLFIGFTFFKPDNNLQGFQDVLFSAFMLCSIFSTLVQQIMPKFVVQRSLYEVRERPSKAYSWAAFLVANVLVEIPYQVLAGIIAYACYYYPTYGANQASHRQGLMLLFVVQFYVFTSTFAALVISALPDAETGGSIATLLFIMALTFNGVMQPPQALPGFWIFMYRVSPLTYLIAGITATGLHGRGIQCSNEEMSVFNPPSGQTCGQYMSQYLQVAPGQLYNPTATQDCQYCQLQNADQYLASSEIYYSQRWRNFGIGWAYVGFNILGTVALYYMFRVKHYNPTSLVRGAVQGARVVCRVFKRRSGQTPKGREAENGRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDL4</accession>
    <name>A0A317WDL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Trehalose synthase (Ccg-9)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_566611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466398.1">
        <property type="nucleotide sequence ID" value="XM_025614570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDL4"/>
    <dbReference type="STRING" id="1450535.A0A317WDL4"/>
    <dbReference type="GeneID" id="37116713"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03792">
        <property type="entry name" value="GT4_trehalose_phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052078">
        <property type="entry name" value="Trehalose_Metab_GTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049438">
        <property type="entry name" value="TreT_GT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47779:SF1">
        <property type="entry name" value="SYNTHASE (CCG-9), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12100)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21269">
        <property type="entry name" value="TreT_GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trehalose synthase N-terminal" evidence="8">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="7">
        <location>
            <begin position="455"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY84473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="688" mass="77223" checksum="7EDC56A58A6C2501" modified="2018-10-10" version="1">MTGDAPQPFQRRSSFHQLQVSHQFDKNSWEAPPSKTIYAGLSALFDNDGVTVALAIRDTTYLLDFHQEDLVAQGGRTICAEITDYVLNQLREYSDDHLEKFIGLAMPTSVAQRCPNLCSRLWSELDVIPLVLPEESNIGVDHHVDHPVRKSTGWELKSIDEQAESMGRKCVRLFGPENIPLLQVGFLGLVEVDTAFHVRLTNLEDFQNTVTKKTWDAVQYYADDLKKRGTKIAFFSATPQGGGVALMRHALARFSYSLGTDIKWYVPKPRPGVFRITKNNHNILQGVAPPGERLSKEDWDKVIDWINENAKRYWLSPGGPLRPPSEGGADVIIIDDPQMPALIPIAKHLAPDRPVIFRSHIQIRSDLIDQPGSPQEEAWSWIWKQAQQADLFISHPVSIFVPSNVPSEKVGYMPASTDWLDGLNKNMREWDVAFYGRVFNSVCRNSGTLTINYPQDEYIVQIARFDPSKGIMDVVESYNKFYRRFTAALPDRTPPKLLICGHGSVDDPDGAVIYDSVLNYVEEDLSDIADKICVVRLGPSDQVLNALLSKAKVALQLSTREGFEVKVSEAIHKGTPVIATKAGGIPLQVADKKNGFLVEVGDTDAVAQHLFDLCTDEELYERTKKFALENVCDEVSTAGNALNWLYLASKLSKKEEVKPNKQWINDMARTEAGQEYSDKESRLRRISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFT2</accession>
    <name>A0A317WFT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA ligase</fullName>
            <ecNumber evidence="7">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_536127</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466486.1">
        <property type="nucleotide sequence ID" value="XM_025611942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFT2"/>
    <dbReference type="STRING" id="1450535.A0A317WFT2"/>
    <dbReference type="GeneID" id="37114085"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000218">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000018">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 7 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="10">
        <location>
            <begin position="517"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="607"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY84561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="831" mass="92911" checksum="CCE020C24C18275C" modified="2018-10-10" version="1">MSSPAKKRKRDDPGSTSQPTRTIASFFQGQATKQPEKTQQPPQAVFEAHTQQTLSDEALARKLQAEWDKEDALPTPQADTSDDPSLLPLNAGDNDREPTKVQKKGVLSLQSSTGTEDTVSLAVPFDQSPVTFDATKYARELQGHWASEGGDASYALLTRAFVLANATTSRIKIVDTLVNFLRVVIEADPSSVLPAVWLATSSISPPYDELELGLGGSSISKALKKVYGLNSQGLKSLYDRHGDAGDVAFEAKKRQSFTLMKPKPLRIKGIYQSLKKIAMSKGGGSQETKQRIVEKLLQDARGAEESRYIVRTLVQNLRIGAVKTTMLIALARAFLYSRPEGAEFSIYSQEEMARLKKDELAESYNNAEEIVKASYARHPNYDDLVPCLLEVGVSDELLVRCGLQMHIPLRPMLGSITRDLSDMLTKLQGRDFSCEYKYDGQRAQVHCDVQGKVSIFSRHLENMTEKYPDLVSLVPQIRGEGVSSFILEGEVVAVDQESGELQAFQILTNRAKKNVDIGAIKVSVCLFAFDLMYLNGQPLLDRPFRERRELLRSLFVEIPRRFTWVKSLDAMSADSEAVLEFFKSATDTKCEGIMVKVLDNMTKPVLEENGTPAVDTDGVPDQPSKTDEKSESKNSKGSRRKALFSTYEPDKRLESWLKVKKDYSASSETLDLIPVAGWHGQGRKAKWWSPILLAVRNPETGSLEAVTKCMSGFTDKFYQTNKDKYAEGTPNVISRPSYVEYYGEPDVWFEPQEVWEMAFADITLSPTYTAAIGLVSDERGLSLRFPRFLKVREDKSIDEATTSDYLALLWRKQSERTKQEVERPAEEVLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKD8</accession>
    <name>A0A317WKD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_575746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466759.1">
        <property type="nucleotide sequence ID" value="XM_025615098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKD8"/>
    <dbReference type="STRING" id="1450535.A0A317WKD8"/>
    <dbReference type="GeneID" id="37117241"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="144"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="386"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY85742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="558" mass="62006" checksum="C077B5D9DA7B7330" modified="2018-10-10" version="1">MSNMSLSDSELSSLSSAPPSDEETGSMAIDEPVGIAKYFKKESESPPPKREPSPPHEYVLADNSDIAFIVMFRARFHDAFPRSTPHFGPQDIERGVAESPPGDHIERLLCAFLGLVLNRKKDVDRNHYQRPLEEAIQTHASQWPKAWQGKNPLHGGRTFATMSPEERLQLLKSLILWSLASSDAVQAKIKESYKQARHEDDLNQPLSVQPWGRDGLKRRYWLVEGLDDTHFRLYRESNPSLKNVSWWSVAGSIPELKAVADKLDTEKSMHSKKLSEKIRNSIPRFEGSEEKRKRRDYRIARKAAFARPEPGFSLYEGRTRGKKLKYTYSDDEDIFSDGLPSTRRSTRNASGVSTPPEPTGPRFTASGRQIRSRAGGLYGEALLSGQREDVNAGEDDRPSRTRATRANGYTDYDVDEEMDEGSEGAQSSGNEWQGGEEEEDNDFEGDDEEELSGDEAVLNGETPSLVVQLRYNKDKAPSSPSGPADEHLAGRLESKDEDMAKPATATNTEDSSQVQPQPELNGQSTAAKSPPDAAVSATVPASVEVSQWPLMQAQTKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKW3</accession>
    <name>A0A317WKW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_586259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466714.1">
        <property type="nucleotide sequence ID" value="XM_025615752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKW3"/>
    <dbReference type="GeneID" id="37117895"/>
    <dbReference type="OrthoDB" id="4357148at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY85697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13382" checksum="0EB0358FC23AC513" modified="2018-10-10" version="1">MSNRYERSAEDAYEAQNDPSPVSGTYRDNTYAHETQSSLRGQVPVAKDEDYYDDPMQPPYSNSDQQLARDEDEALDQSNVIQGRTRGAKPQTRNLYNEGPEEDDLPDEVLYGNSGVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLU5</accession>
    <name>A0A317WLU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_74607</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467517.1">
        <property type="nucleotide sequence ID" value="XM_025617643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLU5"/>
    <dbReference type="STRING" id="1450535.A0A317WLU5"/>
    <dbReference type="GeneID" id="37119786"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="161"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="479"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="773"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1057"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="786"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="843"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="903"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="966"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="991"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY87309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1080" mass="119994" checksum="2E0A897399EED23C" modified="2018-10-10" version="1">MPPNVPTANEDPEPKTPADMVDSDQDAEGEEETDLYQMDQQLQDAVHRAFTGEAAEDAATGDPGDDQDAEGEPDTDMILDGDQNDAEPVGAVKLPQNGSAVDDEEAASGTADADADPAFDNQSDSDQEASRSSSSSQESDDEEWEGESNDHEDAEAEILIRGNCIFCDQDEDNDPSEEYEEYLACAVCGDHSHRQCAREQNALDDVEDGNPWRCPTCVREKLKPSSEEDAPTQRKNREKNMRKELLPAHTGEDGSDFHSIFNTVTVNEELLNSSRSLRKRKTMSLSAEFEEHTPALRKRQRQSPLRFDRGVSREQLAETHDVLSPVRTRSRRTRRTEQEHCRVVLKQFERLVLAFRLNESKLSKIFNAHTRSQNRSRRTPKPAPVVHESQAHFAPITPASYYTPFLSFSDRETDELKGKPYGGILSEADADTSKTLPTHLDRERFEKARQKAEEEWQKRALAAENTGETVQHASQKVSGPPSRIKYINFGGYEIETWYAAPYPEEYSRNRILYICEFCLKYMNSDYVAWRHKLKCPAKHPPGDEIYREGSISIFEVDGRKNPVYCQNLCLLAKLFLGSKTLYYDVEPFLFYVMTEFDDLGCHFVGYFSKEKRPSSANNVSCILTLPIHQRKGYGNLLIDFSYLLTRIEGKTGSPEKPLSDMGLVSYRNYWRLILSYQLRDQKAPLSITDLSERTGMTADDIVSGLEALRALVRDPVTKAYALRLDYQYFEECIANWETKGYVQLNPDALVWTPYIMGRSNQSQFDRAPLHAVAPREGLEEEESEDVKESGNEEERQSPADVDGSKDDGPGPMANGTKEVQLPTEPAGPPSTDRLGHVNGFRHPTTTSAGSSTPAESNPAGDVPAWRFEIYPPVQAPASKRRPGRPFGSKTAKIPGTPIPVRTSGRNTPRRTSVLASVTPSANPQSVRRGRSAKLIDSPAVESTSVEPDGIGNEPYDDMENIPADSQAISSQVHVSTETALTNHAVGEDELPTSNDSSDPGNDQENDPTEHPAVEPVTPSKGKAVEGKAKLSKSVSRKSYVEKLELVVAAEDTALSTHENGVVDKAPVNGMDADGDTVMET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNI9</accession>
    <name>A0A317WNI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">LuxS/MPP-like metallohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_535048</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467822.1">
        <property type="nucleotide sequence ID" value="XM_025611687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNI9"/>
    <dbReference type="STRING" id="1450535.A0A317WNI9"/>
    <dbReference type="GeneID" id="37113830"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="116"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="310"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="10">
        <location>
            <begin position="494"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="11">
        <location>
            <begin position="888"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY88039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1193" mass="135140" checksum="A422790EFD155C91" modified="2018-10-10" version="1">MPPRSPATRRLWNSRHPSYLRSSATRSFSQSGAFAAIAPHFSSPSPRFPSAHGRRSSPAVRSSHAFVSLSPTTRASFSSSTAIMGSIERIAESLEKPELDDRSYRVIRLPNRLEALLVHDPDTDKASAAVNVNVGNFSDADDMPGMAHAVEHLLFMGTKKYPKENAYNQYLASHSGSSNAYTAATETNYFFEVSATPASTDETPNKAGPNGSSNDTVAVQESSLPASPLYGALDRFAQFFVEPLFLESTLDRELRAVDSENKKNLQSDLWRLMQLSKSLSNPGHPYHHFSTGNLQTLKEEPQKRGLEVRSEFIKFYQAHYSSNLMKLVVLGRDSLDEMEQWVGELFSDVKNQNLPQNRWDDAQPWTPEHLGKQIFAKPVMDMRSLDIYFPFMDEEGMYESQPSRYLSHLIGHEGPGSILSYIKAKGWANGLSAGVMPVCPGSAFFTISIRLTPEGLKQYREVTKAVFEYIAMIKEGEPQQWIFDEMKNLAEVEFRFKQKSPASRFTSRLSSVMQKPYPREWLLSGNLLRKFEPELVTKALSYLRPDNFRMVIVAQDYPGDWNCREKWYGTEYKIEDIPDDFMASIRKAVETSPEHRLPELHMPHKNEFVPTRLSVEKKEVSEPAKTPKLICHDDHVRLWYKKDDRFWVPKATVNITLRNPLVWATPANLVKAKFYCELVRDALTEYSYDAELAGLDYELSASIFGLDISVGGYNDKMSVLLEKVLTSMRDLVVKPDRFNIIKERLTRGYKNAEYQQPFYQVGDYTRYLTAERNWLNEQYAAELEHIEADDVSCFFPQILRQNHIEVLAHGNLYKEDALRMTDLVESTLQSRTLPESQWHVRRNVILPPGANYNYERTLKDPANVNHCIEYYLFIGNLDDSVLRAKLLLFAQMTDEPAFDQLRSKEQLGYVVWSGARYSATTMGYRVIIQSERTAPYLESRIDAFLTAFKKSVENMSEQEFESHKRSVVNKRLEKLKNLNSETNRFWSHVGSEYFDFVQNEVDAANVRTLAKADILQFYQQFIDPRSATRAKLAIHLKAQAGAHAHATKPQEQKSQLVSFFGNQLEAAGFAVDTDRLNAAFETVDVSSGDEAQILATLKAFLESGMSLSEQQAKPVLEQVEANLGIQLKQAGIEAKKSDGEAAKSNGVVNGTNEDIQPPTYISSVAEFKARLAVSAGPSPVTDLSEFEDFDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNN3</accession>
    <name>A0A317WNN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_575045</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467766.1">
        <property type="nucleotide sequence ID" value="XM_025615056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNN3"/>
    <dbReference type="STRING" id="1450535.A0A317WNN3"/>
    <dbReference type="GeneID" id="37117199"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="145"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="351"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="624"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="702"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="493"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="578"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="594"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY87983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="747" mass="82457" checksum="62542F232ABC06DD" modified="2018-10-10" version="1">MRVLTWLTGYIGLHGLLKSIQKPCHLKRFSGQTLGVDAYGWLHRGTVACAVDLVLGRPNRKHIDFVLNRVRMLIYFGVVPYLVFDGDELPSKLGTEVERHKRRQESKALGLELQRKGRTAEAYQELQKAVDVTPLMARELIEELKKMGVQYVVAPYEADAQLAYLEQQGIITGIISEDSDLLVFGAKRLLSKLDQHGDCIEINRADFSACREVSLIGWTDDDFRRMCILSGCDYLPNIARLGLKTAYRSIRKYKNVERALRMLQFEGQYHVPSDYLDNFKQAELTFLYQRVFCPKAGKLVTLTAPESDTKLEDLTFIGGDVEPETAVGVARGDLDPTTKEPLVLKPTVPADKRLTNTLSRRQTLGSSAELKSNKPISSFFTPKRVPLAELDPNSLTPSPSQQRLLQRHANNSWDSVPAPSRTGLVRSASSMGSSSRPSSPLVRSVERNSFLAHASRTSNLQPAKRQRLCSDADETSLPNMPDCRSRFFAGTLDDSSPSAQKITRTKKVRKSTLDVFSDDSAEDLMSQLPDPVQTTQEPKDQIHATTDTNSSTADDSALGPPATVTSEPGLDAGEGQTEEQQSSSANQALESSSKPVSLGSNPSPLRRQNSALLSKYVFQAGNACVRPRTDGPGGKGSQPDSLNKSTPGTRTPPRRQRTTPLQRLGQSALARSRSLNCVSLTAFGTSKRPMKNPAIEKRELRSAQTLTAPSQGSEDMIIPDSEDEDDEIRTQETPVSFDVQRFSFMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WP95</accession>
    <name>A0A317WP95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SH3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_534823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467618.1">
        <property type="nucleotide sequence ID" value="XM_025611629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WP95"/>
    <dbReference type="STRING" id="1450535.A0A317WP95"/>
    <dbReference type="GeneID" id="37113772"/>
    <dbReference type="OrthoDB" id="27823at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106006">
        <property type="term" value="F:cytoskeletal protein-membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07651">
        <property type="entry name" value="F-BAR_PombeCdc15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000045">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000164">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="F-BAR" evidence="10">
        <location>
            <begin position="13"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="9">
        <location>
            <begin position="923"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="341"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="652"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="419"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="702"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="723"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="746"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="808"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="887"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY87835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="983" mass="108042" checksum="EB05E4CAF0260149" modified="2018-10-10" version="1">MPGTVAEGPTVAMSFANNFWGKEDAGVGPMLDRMHTSKVSCDELKTFYNIRAAIEDEYARKLLALCRKPLGSTEIGSLRTSFDTVRGETEAIAKAHAAIAGQMKRELEEPLVAFAGGSKERRKIIQTGIERLLKTKIQQTQTVNKTRDRYEQDCLRIKGYLAQGHMVMGHEERKNKAKLEKTQIQLASSSSEYEAAIKVLEETTVRWNKEWKSACDKFQDLEEERLDFTKSSLWTYANIASTVCVSDDASCEKVRLSLEDCEVEKDIIFFIKEKGTGQDIPDPPRFINFCRGDINDTSSEASEEEGYSVAQFQRTINPAYRTSSPQPSSYEPQIDPDAEIAAKINGPPTPSSRETTVTPQKALQQPMPQPVQKHVQPPMQQPPQQPVQQPVHQPPMQQPMQPMQPMPPPMQPPVQQAMPPQPMQPPMQQPAPLDLRRGGHPPPNYDPSQHGEITKVPHNAYPTDGMTMFCRTGPPSERSSGTNSAYRPSSRDSQSEVSNPTSMSSQEPSSARQSPTKPTNGVALPGLGGDKQVQKKRSAFFSNSPFRRKSRHDKDRHSGPSQAPSRGTWESPSKQISPTKASHPQQPIAMPDPGSPEPADPRANFQLNVGNNVFDVESPDKDKKVAQPQAGKNGEEELDPIARALADLKVAGKQSTTRVSADRYHGIATPVPSVAPVPGSVATPPPAYNDSSLKRLDAPQPAFTSAQMQKTTQRYTGQGQSAHRGSSKPPSLSSRHSGQSQEAPRARSPAARRSASPNVSPRVDTRMGQYSRAASPSPSAYQSNSMKNRYSQSPTIATPPNVPRGSSRAVSPQPQYRQSPTMASRAVSPQPQYRQAQNTMPRAVSPQLQFRQQVRPSSAGGMELQLSGPPDMYAGSRDGYGSRRGSGRPMSYYDDAASVRSRSRSRTVAVADPSRQFSRDGRPILHFARAMYSYTAAIPEELGFSKGDVLSVIRLQDDGWWEAEVTTARSRTGLVPSNYLQII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQM2</accession>
    <name>A0A317WQM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_491246</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468091.1">
        <property type="nucleotide sequence ID" value="XM_025609150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQM2"/>
    <dbReference type="STRING" id="1450535.A0A317WQM2"/>
    <dbReference type="GeneID" id="37111293"/>
    <dbReference type="OrthoDB" id="2110361at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF1">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="65"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="734"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="770"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="796"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="818" mass="90675" checksum="52E2C5765F4BA40C" modified="2018-10-10" version="1">MQAHYYHSSTNPNQPGGSYELPPVHAVTSPPAPFQPHGPAAPLLSAPPSRPDSGLRMAHLLQPLAQHMPNPPPPQVTNVPTYSRSYESSGSPAEGVSMLPDAPSLNGSGLLQPVGGGGAAGPHAHHQAQQPLQQKRAYRQRRKDPSCDACRERKVKCDASESSSCTECTNRKVRCQFTKETNRRMSSIKQVQDLEKQLLSTKQQLHQLRSGMLRSDNLMDLDIDGAGQPQLKLPDVGYRPPRRPQAPVMQDLTEARANLRKYGRGILRVPPPYRQQGPKSLLSTDPPPLPPKEVANRLLAQYYSCIHSVLPVIHWPTFVNEYENVYQAGTLLGVSREWAAVLFGVFACGCLHTLEANREQEGKEFVKVSCGVIDVWQDNFTLDQARAALLASIFLYEVNSQSASWVWIGSAIRVAQEIGLHLESGPWSPLEGEIRKRLWWGMYTWDRLLALEMGKPVLINDQDCDVDLPCPIDEQYLSDGNFVPESPQTSPLLATIHVVRSIGQLSRTLRSSTISQGTLETFERHLNTCLATFPPQYHPKADQFLDPRTLAPILYLQNARLILHRHNISPFCAPETRSSALDYCVSTAQDTARLLSRCMRPPSSPGHGFVTTAGDDWRPLLASSASTMLCAHLWRSILLLLFRQEYAAALICVQASAAIGDSRAVNAACGRYLAFFLKAVLDRLRRNELTVLERDEELMAYVSGDMQGTAEAGWIWQGSETGSQLETMSPKINSPVAYSHTESNDRPSGGSESWDGWSWVEQTVQYLSERTQQQQELQHRTKPLESMYLGPETANTSSDATTPQSSSSHSRMTIASII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WR22</accession>
    <name>A0A317WR22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_556272</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468228.1">
        <property type="nucleotide sequence ID" value="XM_025613853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WR22"/>
    <dbReference type="STRING" id="1450535.A0A317WR22"/>
    <dbReference type="GeneID" id="37115996"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY88866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26497" checksum="3CDE04B84C737E4A" modified="2018-10-10" version="1">MSFEVTSKPDEPLMIGEDDFLEEPGRRKQSQSRTWSSIRTTVLAVVAAVLLFGLGVAAGKNLPTRPRGLLGRTGYPSPIPHFRHMKTNTLIAPEGNVNVFMEYNSTFTLHPSPESNAAWDALFPTGKGFVKHPTIAPETSGIVVYHGLHCLNALREVYYAAVDGKLAHMADEHDHQTDPHHVRHCFDYLRQSLMCSADTNLEPVSKDLKGVTGWGFTRTCRDLEGVKAWAEKNWSNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WV71</accession>
    <name>A0A317WV71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_623667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468622.1">
        <property type="nucleotide sequence ID" value="XM_025617166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WV71"/>
    <dbReference type="STRING" id="1450535.A0A317WV71"/>
    <dbReference type="GeneID" id="37119309"/>
    <dbReference type="OrthoDB" id="414774at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588">
        <property type="entry name" value="TPR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45588:SF1">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY89711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="98630" checksum="2FC40985D22F8914" modified="2018-10-10" version="1">MNSSDTQSLARPSSDPYFNLGTFGRKVSTDSQEAQVWFDRALVWTYCFNHDEAITCYNQAIAHDGNCAMAYWGVSFCSGANYNKTWALFDETDRLNAIKQCYVFSQEALRRIEHASDWEQGLIKALAHRYPNDDPSRDFAQCSRAYADCMRDLYTNLGREDFDIITLFADALMNCAPRKLYDASTGLPIAASPVCEVKDLLERALKMPGVEQHPGPAHMYIHLMEMSATPEAALPAAEMIREIFPDTGHTYHMPAHIDVLVGDYRRAVEYNLKATVADDKYFQQNGGLTFYSYYRLHDYHSLIYAAMLSGKLKAALAATDRMEATITEDILRVETPALANWMEFFKAVRVHVLIRFGMWEDLKKLDPLKDKQLYCVTNVMRHYGKAIAYAATGQLEEADREREQFNGASTLVPPTRLDFPNKITDILKIASAMLDGEIEYRRGDYETAFSGLREAVILEDELPFAEPWGWMLPARHAYAALSLEQGMVEQAAQAYAEDLGLITTPKRAHQHPNNVWALHGYHECLQLLSRHAEANIIKKQLSLALAEADVQITSSCFWHSGQQLSLESVLDFSQPLNLPPDQSQTAINIFNQLIDLYNPNQTSQKGYKPAALALAVYRHVSAKDAFLMLFFSLIYEALCPRTTDTRDPEITTYLCYFDDLASWGPDRLGNAKSAIEDFAEYIIENLLLPLASYEIIIGVLFLASSIDAKPEDVFSKMAEITDSKKNALRILTMFDHGITHLIEYPKIDSLMNALTLTYDYRRLFGAFELYFEHTGRPYQYEIKSTDQDSFFSDPLLPVIRTLTLSPNRTIDPPFPRLLAIHRAIALIMKISGAGDYFDNVLRDLEEVGVRADGSTNLGLIMKLRLGGWLTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WV75</accession>
    <name>A0A317WV75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 8">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_533831</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 8"/>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468702.1">
        <property type="nucleotide sequence ID" value="XM_025611406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WV75"/>
    <dbReference type="STRING" id="1450535.A0A317WV75"/>
    <dbReference type="GeneID" id="37113549"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF31">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="9">
        <location>
            <begin position="39"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="10">
        <location>
            <begin position="274"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY90324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="433" mass="47759" checksum="24161DD1EDD2F9B0" modified="2018-10-10" version="1">MPDYTRKHKVAVVGSGNWYARSLSHTSHPRFLTRFDTRGSTISKIVAENTKEHSDLFEPEVRMWVFEEDIEIPKSSKHHSKLGGQKRKLTEVINDVHENVKYLPGITLPDNVVADPDVKSTVKDATLLIFNLPHQFIGKTLDGIEGHHLPYARGISCIKGVDVSDGTVTLHSELIMERLGIYCGALSGANIAPEVAAEKFCETTIGYDTPPMDLKQPDGSPKDNLVKVDEQRQHKTKPTHVKLHPVPQDLPHVNAELFESLFARPYFHVRHVRDVSGVALGGALKNIVALASGFVAGKGWGENAKAAIMRVGILEMVTFGRTWFPKSVDERTFTEESAGLADVISSCSGGRNFRSACHAVEQGVSVNEIEEKELNGQKLQGTSTAYAVYDFLAKHDQLKQFPLFVAVHDILEGKATVDDLPALLDGKKKKKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW87</accession>
    <name>A0A317WW87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DUF726-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_490644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468493.1">
        <property type="nucleotide sequence ID" value="XM_025609127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW87"/>
    <dbReference type="GeneID" id="37111270"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049545">
        <property type="entry name" value="Gta3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20978">
        <property type="entry name" value="Gta3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="Glu-tRNAGln amidotransferase C subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl-tRNA amidotransferase complex subunit Gta3" evidence="8">
        <location>
            <begin position="60"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="803"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="803"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="836"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY89582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="883" mass="96232" checksum="F00C1C08C74A7E41" modified="2018-10-10" version="1">MFLRTGSLRLSGLVRRQELRSNARRMYSSQSDDADIDAMLAKPTWSVRSLLPEENANASAPSVTPTQLRHLLRLSALPQPANEEEEKNMLETLESQIHFVKQIQRVDTTGVKPLQSIRDESPAAVKENTIGLEQLREALSKERVVGRNKRIQRVESPRNDRPDGDTWDGNALAYASKTKGKFFIFGSGPSPAPPKSDRDQDLTTTLDRPQRADLTVLVAEITQHMRDAIVQNFHGPVSTENHASRDQSEGDHNNDTDSLSTPSDAQKEETSAVTSQSEYQPTAQDLKSETRALTSFDDWRDSVLLRIGEVVNKDNEGSDGDYTPQQLQEPQIDEDQGSLKKLCEVYPPVETPLAQLPKAKRLLILHSLLLLMLSLEHYNSRSRVLMLYVSSSLNLDITILNGDETQVARGLLDTALQLASAEAESQGKKRDSSRKWKVGAASVAGAVLIGITGGLAAPLVAAGLGTVLGGIGLGATAAAGYLGALAGSGVIVGGLFGAYGGRMTGRMVDKYAREVDDFAFLPIRGSQQRSEDEREAAQNDHMLRVTIGITGWVTEEDNFVVPWRVIGADTEVFGLRWETEPLMKLGNAMNLLVTSAAWAAGGQVLSRTIFAQIMSAVMLPLGLLKVARVADNPFSVAKARADKAGEVLADALISKVQGERPVTLVGYSMGSRVIFSCLQSLAKRGAYGLVESAILMGSPTPSNAPHWRRLRSVVSGRLINVYSENDAVLALLYRTSSLQLGVAGLQPVQGVTGVENLDVSDTVSGHLRYQFLIGRILGLVGLQSIDAREVAREEAALAVKVRKQEQERIQNERRAGVEGDESAHRILENGEGSGEEAMHAEMEQKTRERLSRLEVRKEIKRRPVPSEPRDEGSPPPSEHSGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWT5</accession>
    <name>A0A317WWT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_574133</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468739.1">
        <property type="nucleotide sequence ID" value="XM_025615005.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WWT5"/>
    <dbReference type="GeneID" id="37117148"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="9"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="971"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2466"/>
            <end position="2543"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="971"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1118"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY90361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2554" mass="276265" checksum="83A7532E091ABA07" modified="2018-10-10" version="1">MALTSTPQSEPLAIIGLACKYANGINSPRDLYEQVMAARSMHGPMPATRMDASFYYHPSSEATGTTYSKGGYFLQSDLNAFDSPFFQLSEIDVLAMDPQQKMLLENVYHALENAGIPLQEAVSSSTSVFVGCSNNDHLALANSDLLLALKGKGTGTSPSILANRISWFYDFHGTSQTIDTACSSSLVAFHQGCMDVRAGKSAMSIISGVNLMEHPAPTMYLSSLGVLSPDGRSMSFDARANGYGRGEGLGTVIIKPLHAALRDGNRIRAIVRNTGSNQDGRTPGITVPSPTAQERLIREVYKAADLDPSRTGYVEAHGTGTPVGDPLEVQAISAALGVSRESPLYVGSVKSVVGHLEGGAGMAGLISATMAVESKTIPPVAGLQTLNPRIPQRPDLKFAKEATPWPREDVRRASINSFGFGGTNAHVVLEDVEGFFSDLFGQQLPGALQLPEFTTKAMVPSVMKPAVNGAQPPQASSVNRLFIISAFDEAGIQRNAASLASHLESMRAITDSDGEERLLNDLCHTLNDKRTRFDWRSYHVADSIDSLRSSLQNTRPIRQSPAEKVVRFIFTGQGANWAGMASDLLVYPLFRRRIQETSTFMKYLGSGWDLYGMLPSSPLIDSANEYTVERIASESGELDEPTFAQSSCVAVQVALVDLLASWNVTPQTVVGHSSGEIAAAYCAGQISRQAAWKVAFCRGQVCSRRTDGQGRMLAAAMPVTQLERLVARINKGQSTAVKVGCYNSPKNLTLTGRYEDIMRAKLELDDVGALNRLLPVKVAYHSDYMRDAAPEYLDLLGDLDFGDKIHTDAGIKMVSSVTGRAVTAGEAQQPSYWVDNLVSPVRFSAALLASMDDPSAMGSREDALIEIGPHSTLRTAIKETFADVPEFQSSQYGSLLKRYETDGSTILRTFGTLVCSGHEISLAAINDRRAGSKKTPRLLTSLPGYAFDHSRSMRGTSRRVEQTKFPTYKRHELLGVPVEDTNPVEQRWRNVLRPDDLPWLRMNRMSGKIHFPGVAYLLMAIEAAIQRAGNTAISGVRLGNVSMLAPLPIPDSATGVEIQFSIYPMKMHANSGTDWSAFRIVSYDSAEKTWTEHCVGSVRVETGPHEPHPKNALREKCTEPVDITQMYSSFTTAGMDFGEYLRNIEEMKLSPDRHACTATITAPAIPCQAHDHYSLHPCTFESILHALLHLCKSSQGPMVTTYVEDVLVLSPQDTGVRGFEASARTQRASATTWRSDVTITGNTGSQQIQITGLDLVQLPPSEDASDAESFYVVKWKPDVKLLTSVDALRDSASMYVAQHLPTLDEHEGFQLASATFLLDTMEYIARSGLPSLPQHHEAFMKWMEKECRSIADGTVPLLDKALLEGIRASPDRRRDLLARVAQQSARGELLVRVGTQMVPILEQKIDCLEVMFGPDNLMDRTYEEGLPGQIAPSVAGYLHCLAHAQTGIKVLEVGAGTGSATKVILDSLKPTERQDGGGLVSSVSTYHFTDISAAFFEKARARFHDWADILRPKVLNIELDPADQGFEMGSYDLVIATHVLHATADLNTSLNHIRGLLKEGGDLIVIENIQPDLMCSPLAFGLLPGWWRSVEPYRETNPLVTKDQWNQELQNAGLQPRLLIDDSDQGLNEMTAFVASRVREPPATQHVCSIIYLSSYGGQYELASQVARGLPSSCTASLVDLADVSHDHINTIGLVLVGYQGLDLSELSAHEYDRISFLLTAFHRLLWVTCDADETPKSAMASGLVRTARWERDHDGVNFILLGISQPVRSASAAAFQMIRVCDHAFLSHELVPRNAELRLEGSVLLTNRLFPATGINECIASSSRPRSKQVALEAVHHPVKLTSIGPHQPNGFHFVEDQRVDEPLLPDEVKIQICAVGLDESDADDMTRLIPGDSTGSQGAGVVVEVGLAVQDIQVGDQVMALRTGPSGSVQTFLRTHSSAVAKVPEGISLADAATLPLPFATAYHGLVNVARLGPQEIILVHNAGTATGQAAVQFACMLGATVYATVRTDAQRQALIDYGVERSHILDGASFAQQLANRDATRSVDVFFNITRESLQKKDLACLSPFGRLVDLYGQGSLPAGPAGPTNRTYATVSIKELVQARPKALHGTLRTISQLLTSRAIRPIIPVRAGYSELQTVLSQIRQGNAGPWALEPRANDSIPVAMKPLGDYKFDPCASYLLIGGFGGIGRSVVRWMLTRGAKNFIFLSRSGASSVPAKQLCADLLDAGCGVSDTVCDVTDGIAVEDALQRCQKSMPPIRGCLQCSMVLEDSMLSNMTHAQFLNAITPKVQGTIHVASALSNVKSNLDFFVMLSSSAGIIGNRGQANYSAANAFLDAFAAQLVSRGYPATSISLGSVLSVGWVAENQDRLPIALSYGAISEDLLLAILEYHMDPSWGAAQSPGTCHTVAGVRSARDFHRQSIPLPGFMAYPLFSPLRAIAGASQTAEEVAEAPIAQGLRGATSMEDAVELVTRAIVYKLARIMALSAKEIDAQRSLASYGVDSLVTVDLKAWFQREVGATVASADLLGDSAIVQLARQAASGSQLVAAAMRETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY31</accession>
    <name>A0A317WY31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469042.1">
        <property type="nucleotide sequence ID" value="XM_025611333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY31"/>
    <dbReference type="STRING" id="1450535.A0A317WY31"/>
    <dbReference type="GeneID" id="37113476"/>
    <dbReference type="OrthoDB" id="4450798at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="320" mass="36617" checksum="C468F552DABDFD09" modified="2018-10-10" version="1">MSDNVSGSSSTPGEGDELAEVKEWQRQWQRDRETAAERRRRRPWLGRSFYSELEAFQARLKKPTRPTNKDGPRLAFPAPPEQSIAVADFAYIPSTVPAHVQEPHPVHVNEDLGIIQDAITQTTDILTKLRKAWRMVHTIEDTATTDHHVTIAILHVIQVREMAESLYEYVEKLSKALEYTLYQLENSRPPADQATWHDRAGEVTVNVYAMMLLYQDLYEDMNFTVAGYHTARAEARWRTTPRGDNEVQALRQQAKEHRATDPVRPLDYVARTQIPLTGPARPEIHPYPMPTDFVEGAVAFMQVTNNLLKQGQRVRPTPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY37</accession>
    <name>A0A317WY37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_387805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469052.1">
        <property type="nucleotide sequence ID" value="XM_025607305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY37"/>
    <dbReference type="STRING" id="1450535.A0A317WY37"/>
    <dbReference type="GeneID" id="37109448"/>
    <dbReference type="OrthoDB" id="5428925at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="105"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY91324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="553" mass="60808" checksum="A3A0F19C5692562E" modified="2018-10-10" version="1">MSGTSLSTARSGSAESRLADTPASDSSSADACFDTALPPMSSKQLVVSTRRPPRGSESSLIATSLRGNNRAVAALQYSPGTTTIARGPSTHRRTGSTLKTVMRKIFTRKSRGQEDGEEDPAHGRFGNQSPRSDRSFDKPLPLSGSLNGKSISPLQHETGPVTSWEEALRKLEPHPRRRRATLPSLIFSDDESRGALEAVINSDRPTSKRDNSPHANSDPDETRRREVRQIKRRSRSATALRGMAKDHLMSPIQWRRRSLESYAGSTTFGAPSEIDASERPPTRTTVASAPKPTTEPSFLEEADEEEDDEEDNHEENISPMVGTLVNTLQHDENVTLEQRLTTLEVKLIDLECAIARMQSGRSETPAEASGQKKSSPTTSRHKRKQSSARSPSGSDEAPNAKSPGADRPLSTSTLRPNHLHRSRTLQAPSSTSLHECNNTISVEQYSALVMLLRREQSARRNLEEQVSSLRGDVEQLTRMARESMGPMYPVRAIDPQDIIRMRQALGPSPTNSAPTEKNSPDSDSEERPELPPKGDVYHPRWPSARRVEVGGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYJ9</accession>
    <name>A0A317WYJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_462621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469167.1">
        <property type="nucleotide sequence ID" value="XM_025607983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYJ9"/>
    <dbReference type="GeneID" id="37110126"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="67" mass="7097" checksum="70BEDD7D40FF33AD" modified="2018-10-10" version="1" fragment="single">VAVDAFDVRNVAAVIAHEPRSLALNGVLQRAMGTDSLTATISTRLYCISTCQLLVRGAGSGFEDFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ67</accession>
    <name>A0A317WZ67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_463623</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468431.1">
        <property type="nucleotide sequence ID" value="XM_025608031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ67"/>
    <dbReference type="STRING" id="1450535.A0A317WZ67"/>
    <dbReference type="GeneID" id="37110174"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY89520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="359" mass="41022" checksum="7D4F0CF269E61142" modified="2018-10-10" version="1" fragment="single">LPSYSKEHYYPDRIGEVLNSQYQIVTKLGFGSSSTVWLCRDLHTNRYLALKIHVRSNHPPPEVQISRYLKSLPSTNLTGKRYIRLALDSFDIPGPYEIHICTLYEPAGIDIRDYIHCLEGDALPESLLRVTIRFMLIALDYLHEAKVIHTDIQPHNILLGIDDNSILAEMKEDEISDPAPRKQLSDRTIFATRGMPLTSGEPVLADLGEARLADGKGTQRGLIMPSVYRAPEVMLGMNWDSKVDIQGLGQTAWTLFEQGHLFTGQDLETDTDHARRFAEMISLLGPLPVEFLTRSQESLKFWDEDGKWKGCVVIPEQSLESRESRLQDDDKMLFLRFLRKTLSWLPDERPMAKELLMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZA6</accession>
    <name>A0A317WZA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CHAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_623345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468975.1">
        <property type="nucleotide sequence ID" value="XM_025617146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZA6"/>
    <dbReference type="STRING" id="1450535.A0A317WZA6"/>
    <dbReference type="GeneID" id="37119289"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="948" mass="106525" checksum="6E15DCC29D55F3F7" modified="2018-10-10" version="1">MPAPPSWNRLSIDQAASQAYKLLEKNWTTRNIEGLNKVLSQYERLLPHAAVDSPGRCTLLYMIAMALTIRYEVTMASKDIENAVTYTQCALFWLPDEPVLQAGCARALIYRHQSTGFDPDLDHGIVDLEDAMTSPSWNRAQQCENASLLVTAYTLRDRGDDDFERAWSLMSKLIAGMPLDIDEPLTDGFPETEEEVAKLPQNHSLRTEGWILLARRTSSRYNRTGQIEDLETAILALESVLPRLSPGDHVWRRLVQQRLGQDLRLIFQKNADVADIRAAYRHLMKAIRAPLLDEFEKVNLFVELCQVLICRHGATANKDAFNRGVEILESLVPFVRHKKGLCMANLGLLYSYLASAENLWVQDAISKTEKAVASIGVTDPVRAGLLYNLGMLLLERRRWEQADGGAGLGCMVQCCQRPTGSPLARVLSARKAVELLILDGHLERAREVAQMVLHLLPYAFSRDLERQHQQRSLREFKDFASDTCSMLLKQGYADEALITIVFVRDITNPYILDCQRNLPDLSQSHPELAEEYETKQELFAQTAHGGDIGISVRGRRTALHQLQECEERIRQQAGFEDFLRRRTIPELMDCARDGPIVIVNWSHISCEAILIMSCGIDTVPLPDMMSEAPPESKRHLTRNANIGSDAEDADPNYDESDREDDISSLTKELSWLWGTCVHPILETLASHDAISTTGDRSRVWWMGTGAASGLPFHAAGEDDEDSCLHQVISSYVPSIKALQNARARAAEQLERNHRSSVLEIMMVERSEDCWAGGMNHDEQDLLRAEIAVIVRDMGNIRMENPQFRLTSGGVVRFVCTGHPDPQDPAHDYFLLERETESGSVTDGITISTILNRKPTHYRSICSPPEIVYQSINSPTKGLMDELRSTCPAHVVDSMWPCTDDTYNEIQEYFAISDPTRGVAEAVRDALLETRDEFGPKCPAWVTFTHTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZG2</accession>
    <name>A0A317WZG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase</fullName>
            <ecNumber evidence="4">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_513390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469099.1">
        <property type="nucleotide sequence ID" value="XM_025609843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZG2"/>
    <dbReference type="STRING" id="1450535.A0A317WZG2"/>
    <dbReference type="GeneID" id="37111986"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY91371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="361" mass="41439" checksum="69F58A244EA04288" modified="2018-10-10" version="1">MAVTRIQQSVPSPKVKVVRQDTSLTIRLPGMFVLFLSGEPTMNQHYECVRQLSEAWVSRECSFDEKAQRRLHKTDFAYFCSIAMPEVEAEELRTVIDWGNWVFPFDDLFDNGRLKDDPERAEVMIDSLRAGMVDNEQSPVPADNPLVRIHNSVSHRIAKAGIHRRFARTMNNYCTGCMAQVRSCFKGELPSLEEMLSLRRRSAGVSPLFALVEYAHKLDIPDFVFECKSIQEIERIGIDLVLLQNDILSYCKEEKEGVTHNLVAICRHNGMPAQMAFDHVGNMLIERYRDWYLALAELPTWGERVDADVQQYIRGVQNVVRANLHWSFRSGRYFGKANDKVRKTGMVTVRAQSADFKLSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZH3</accession>
    <name>A0A317WZH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_573827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469109.1">
        <property type="nucleotide sequence ID" value="XM_025614988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZH3"/>
    <dbReference type="STRING" id="1450535.A0A317WZH3"/>
    <dbReference type="GeneID" id="37117131"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF238">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="24"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY91381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="467" mass="52112" checksum="67C36CD061C54B0C" modified="2018-10-10" version="1">MGIFNSIIWRDDKTTKMSRHESHLDIIIVGAGLSGLATAICCTMSGHTVIVLEQAKELAEVGAGLQITPNASRLFSHWKLPEKLWKDAAEPTSLTVHRYTGEVLAHEASFDRNIRSKYSAPFIDLHRVDLQQALYARAKELGVTFHLDERVDSINFDTTTVTTLKGKTISGDLIVAADGLWSRCRECLGGKKDDPIPTGDLAYRIVLTADQISDPDLKAWVENPTVHFWIGPGAHAVGYSLRGGKMLNIVLLVPDDLPPGVSRQAGSQEEMMRLFVGWDPILTRFLGYVNGVDKWKLMHHAEMESWINDKSNLVFIGDACHPMLPYLAQGANSSLEDGAVLGSLLGHMKKKSDLPDILRLYEKLRKSRGEAIVRETFKQRNDFHMPNGPEQEKRDQIFLSQLGKELKGAFPSRWTCPEVQPWLYGYDAIKEVENVVVQNPGLFGSKKTSHLYLNGVGLKSWLMGRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1U5</accession>
    <name>A0A317X1U5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1348 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_534021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468898.1">
        <property type="nucleotide sequence ID" value="XM_025611445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1U5"/>
    <dbReference type="STRING" id="1450535.A0A317X1U5"/>
    <dbReference type="GeneID" id="37113588"/>
    <dbReference type="OrthoDB" id="14527at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY90520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="157" mass="18555" checksum="B56BE298C80DF119" modified="2018-10-10" version="1">MADVKPPFTEESARKKVKAAQNLWNTMDPMRVAQAYTPTCIWRNRTSFFSGTEGIIEFLTAKWKREANYKLRKELFSFNDNRIAVQFWYEYQDVEDGLRWKRCYGLEDWTFDRETGKMCKRMMSGNDVLIGPDGNGEGRWFVEGVDLEDVEIGEEHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4L2</accession>
    <name>A0A317X4L2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pantetheine-phosphate adenylyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_345256</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470267.1">
        <property type="nucleotide sequence ID" value="XM_025607067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4L2"/>
    <dbReference type="STRING" id="1450535.A0A317X4L2"/>
    <dbReference type="GeneID" id="37109210"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="402" mass="43532" checksum="972907824C3CCC73" modified="2018-10-10" version="1">MASDQTSALLLLPPPPSASFDKFKAAYEPILSAVCSRLTKELNGANRTVILDIALSLPGLLSPACRPRTKAFSSLQSFLESIYRLIGIVCVEQNLELDGPGGIDARVILLDFDSVQSAAVTRDQPRDGPIIDLQTLAQCGRPWDYIYYPDNQVGQNLATAFSSFYSPSKDPNAGSMHAIPEAPNWTVPESLVTLDDVNKSSTHYSVAVGGTFDHFHIGHKLLLTATALVLQPAEDADTGKARQITVGVTGEGLLAKKKYAEFLESWDERCASTGSFLMAIMDFHLPEAGAPRIERASGPGPDGKYIQMQVRPDLVFKLVQITDPFGPTVTDQGIGALVVSRETRAGGAAVNEERAKKGWESLGVFEVDVLHTGEVPTDDVENFASKISSTDIRRRRIEMATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4W6</accession>
    <name>A0A317X4W6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZW10 C-terminal helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_486970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470410.1">
        <property type="nucleotide sequence ID" value="XM_025609023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4W6"/>
    <dbReference type="STRING" id="1450535.A0A317X4W6"/>
    <dbReference type="GeneID" id="37111166"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.150:FF:000004">
        <property type="entry name" value="Centromere/kinetochore protein zw10 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046362">
        <property type="entry name" value="Zw10/DSL1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055148">
        <property type="entry name" value="ZW10_C_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22766">
        <property type="entry name" value="ZW10_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZW10 C-terminal helical" evidence="2">
        <location>
            <begin position="678"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="833" mass="92753" checksum="3673B8FFAF62749B" modified="2018-10-10" version="1">MSAKASEQEISQSVLDFVTDGTYPESEHLIASDFPTSLLVKELELISKAREQVEAEISFLSRENNFDADGWISQAKQLHADIERSRVTAREIVEQHEKTQPLQLRVEDASAKVGLIETEIAFNQAVASALTEVQKLCGQLDDGRTAIREGRVMAAIETLEATEHAVKQSSHFTNTNVLHILLENTAGLRKDVMEAVRHSWNGQLHIDKREGKLVISRNSVDSLEESIVALTRLGMFSSTKDQFQKELMSRIIDPVLLPGVTGRSHNPRVSESSICLEPQPSVASVPELLDRIVNVLGFLRQCLPGSIADSFSDMSIPLLSSKIIEYWLSPAIPTGLEGLGQFEHILDRVLKFTQSIEGFGWHGQEELNSWVNQAPRLWLARRRVDSLDQVRRILAASQGITQKVERVEVEKVSKSDEALLENATPDDWDAGWEDDNESGSKGKQSATPDDEEDMSAWGLDDDDTEEHDMKSKQSITTTSADDDDAGDAWGWGDEDEEQHAEESQSRVPVITGAASGKEVTHHASPREVTLKEKYTITDIPNSIIGIVKQQVTDFDSISQPAHAHSRVVSSGTGLLALPTLILAMFKATASTFYGLKLNAGQMYLYNDSLYLADQVHNIAEDYQLTRLHADIDALEKYGKLAYSKEMQTQRTIVTDLLDGAQGFSQCSEQPFLGECENAISATVDRIRDVFKEWQPILSHSALLQSVGSLVSTVISKIIIEIEDLGDISEPQSQRLVSFCNQVSQLEDLFIPEALGDTERSPMTAVYVQNWLKFQYLINILESSLADIKFLWLEGELRLEFSPEEVVDLIEALFAESDHRRKAIADIRRASRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4Z1</accession>
    <name>A0A317X4Z1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_554384</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470407.1">
        <property type="nucleotide sequence ID" value="XM_025613709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4Z1"/>
    <dbReference type="STRING" id="1450535.A0A317X4Z1"/>
    <dbReference type="GeneID" id="37115852"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016193310" description="Peptidyl-prolyl cis-trans isomerase" evidence="7">
        <location>
            <begin position="24"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="10">
        <location>
            <begin position="38"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="281" mass="31038" checksum="8C731863B08203E1" modified="2018-10-10" version="1">MNFRNLFLSFFFVLAVGLALVHAEEAQPRGPKITSKVYFDIEHGDKPLGRVVLGLYGKTVPKTAENFRALATGEQGFGYEGSTFHRVIKDFMIQGGDFTRGDGQYSHQSEYLCTGGKSIYGEKFADENFKLRHTRKGLLSMANAGKDTNGSQFFITTVPTPWLDGRHVVFGEVLEGYEIIAQIENVPKGRADRPVETVKIVKSGELESEEKAEEKESSSEESSQPSAIPDVLSPTPLPMTSDNTPYIFPKFAALAIVVGLLVVLVRSSLKRQQEKAERSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X658</accession>
    <name>A0A317X658_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450 monooxygenase otaC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_510171</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>7-methylmellein + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 7-carboxymellein + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:72771"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:192524"/>
            <dbReference type="ChEBI" id="CHEBI:192525"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:72772"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470824.1">
        <property type="nucleotide sequence ID" value="XM_025609724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X658"/>
    <dbReference type="STRING" id="1450535.A0A317X658"/>
    <dbReference type="GeneID" id="37111867"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000069">
        <property type="entry name" value="Cytochrome P450, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00069646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY94063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="507" mass="58965" checksum="035065DBDE86EF66" modified="2018-10-10" version="1">MMILELTHVGLALAGIATFYVSRTFYRLYFHPLSGIPGPKLTAITRLYEFYYDVICNGKFLFQIEKMHQQYGPIVRINPREVHIIDPSFYDEIYASSSRKRDRDHDAYDAFTLPYSMIGTIGHEHHRFRRSILNDFFSKRSVLALSGMVEERVMKLMQRFERIYEDRSVVNLSNAFAALTSDVITYYCYGKRWGFIEDEGFRSEIHKSNEENASHCHFDRFFPFVPEVVRRIPLQVLALLLPSKAAAFEFQAAILQTITTNMQDKPDVSTKENRTIFKKLTDPSLPAEERALRRIQDEVFTLLGAGTETTASTLMVMIYHVSQDEGIRDKLRSELKQIMPTPTGVVTWTELEKLPYLTAVVNESLRLSYGVIMRLPRVAPTEALRYKNYVIPAGTPMSTSTYFVHRDPAIFPEPDRFDPERWIRATERRENLTRYLVSFMRGSRACLGMNLAYIELYLTIAHLIRRFDFTLHNTNPEDVRITRDRIIPCTERGMLRVYARVTGMMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6B1</accession>
    <name>A0A317X6B1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_622066</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ELP1/IKA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470462.1">
        <property type="nucleotide sequence ID" value="XM_025617040.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X6B1"/>
    <dbReference type="GeneID" id="37119183"/>
    <dbReference type="OrthoDB" id="40048at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056167">
        <property type="entry name" value="A-sol_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056164">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056165">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006849">
        <property type="entry name" value="Elp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056169">
        <property type="entry name" value="HB_ELP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056166">
        <property type="entry name" value="TPR_ELP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12747:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23925">
        <property type="entry name" value="A-sol_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04762">
        <property type="entry name" value="Beta-prop_ELP1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23797">
        <property type="entry name" value="Beta-prop_ELP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23936">
        <property type="entry name" value="HB_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23878">
        <property type="entry name" value="TPR_ELP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017233">
        <property type="entry name" value="IKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="ELP1 first N-terminal beta-propeller" evidence="7">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 N-terminal second beta-propeller" evidence="8">
        <location>
            <begin position="407"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 alpha-solenoid" evidence="10">
        <location>
            <begin position="697"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 TPR" evidence="9">
        <location>
            <begin position="911"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="domain" description="ELP1 three-helical bundle" evidence="11">
        <location>
            <begin position="1172"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1164"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1164"/>
            <end position="1180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1333" mass="149271" checksum="7D8A6FB945D6C29D" modified="2018-10-10" version="1">MRNLKTVRLTEVQLQNELPLTSSAWDTASDAVVCTFGPTASNPVIELRRKRHDAYFSEPVGADAFECIASWDAPCPLPDLECDRVLSLHYFADNLTACLVLEGGDIIIVREEPLPGEDKIEIVGSVDVGITAAAWSPDEELLALTTRANTFLYMTREFENVAEITFAQEDLQASQHVSVGWGKRETQFQGKRAKALRDPTVPEKVDEGKLSSSDDGKTTITWRGDGAYVAVNSIEAGVRRAIRVYSREGTLDSISEPVDGLEGALSWRPSGNLIASIQRRDDRVDVVFFERNGLRHGEFTLRLTEEERSTWATNIHLSWNVDSTVLAVQFHDRIQFWTTGNYHYYLKQEIPMVVNAEYPYPFVFKWHQEKALRFIAGALASMLDVDFVFDVSQGSTTSSDDVGAVAVTDGKTLKLTPLRLAGVPPPMAHNELTLDSNIIDVAFSKSGTRMAVLMKDCFSIFLWSLKTRPVVSPILESSYPLSETPDSRPRQIAFANEHEVYILKDNGPNNTHIERTALETRSTQIVYQAADSEQILSIFTSLGHDALWFSHVKAPNQPITYSYISMPSSDEFQVLPWLESPTVDTYWAKAVQVSEDENVLVTMARSGALYANKRLLAKNCTSFLVTQAHILFTTSLHLIKFVHLTAAEEMDIPPDTPETDERCRSIERGGRLVTVMPTTFAVILQMPRGNLETIYPRALVLAGIRTFIDRKNYRAAFLTCRSQMVDMNIIHDYAPEQFMENIQLFVDQVKRIDFIDEFISRLSEEDVSETLYKDTLKAPKADITQPGLVAPALSKGSKVNRICDAFLSTLEKRLDTNLHNLITAHVCKSPPDLESGLQLVARLREQAPEQADDAIEHMCFLTDANQLYDNALGLYDLELTLLVAQQAQRDPREYLPFLRKLQQLPELRRYFEIDNYLGRTSKALKHLHALSAHDEIRAYTIKHVLYKDAIDLYKYQAEQLRDTTHLYADYLFDRSQYKEAGIAYESLELYTDAYKCYHLAHLWRESLYCAMMVPLSPTELANHATTLASTLTEESKDYISAAQIHADHLRDIPTAARLLCRGSRFSEATRLLALNNQQTLIPEIVDSGLADSMGSMTDLLADFRSQLNAQVPRIRELRVRRATDPLAYFGGDPTMGDGTGVDIPDNVSLAPTDASTLAGRSMFTRYTGNTGKTGKTSSSRHTSKTRRKEERKRARGKKGTVYEEEYLVNSVRRLLERANSTVGEVEVLVDALLRRNMRERAAAIEKAMQEVLKLCAESREEVFGALVPEAAKEGEEGDRENVDVGAAAGEEFPGAGARGGQSVFWDSVTATANVGKGREVPAVKEMKVSALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6K7</accession>
    <name>A0A317X6K7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470964.1">
        <property type="nucleotide sequence ID" value="XM_025611063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6K7"/>
    <dbReference type="STRING" id="1450535.A0A317X6K7"/>
    <dbReference type="GeneID" id="37113206"/>
    <dbReference type="OrthoDB" id="4204700at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="411" mass="46820" checksum="FB349C1C9E7BEF2C" modified="2018-10-10" version="1">MASSNDATDSPPDDPSPIFTTFHPGAINPALFHKPDFLTLHLRWGSQRTWTRVAHERARLTIQKQMSMVQRPLTQPETDCIVERSTRHLYHQVFGVPIGMLIGVVRNIQIVKKHPTYLDLFKGFEENPTREAFNLAMDRFKAADPVAYRRAMFIGGVRVLWWMMLGQFMWNHWINMRSLMKALADDRMKTFFEDYKNAVKTADVRGVAPGIVPAIWENRSNYPKGQIPVQEQEQVQQRDIVYGGSGSDEEATKFGASTTTWGSREEEEKMKKVEEQRSRPRWFGPDGAGTLPPAARVRAPAVPEPSEDKGGVFWEDEDDASPVAPAYRDSIPGESAWDRIRRQNNGGASQQRPVSKPVQSDPVPDRDHGRSSEREQAQAEFDKMLDNERKMSTDVLQGTQQKNGAWWGKWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6P0</accession>
    <name>A0A317X6P0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ams2/SPT21 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_327568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471057.1">
        <property type="nucleotide sequence ID" value="XM_025606950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6P0"/>
    <dbReference type="GeneID" id="37109093"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000067">
        <property type="entry name" value="GATA transcription factor (Ams2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ams2/SPT21 N-terminal" evidence="2">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="756"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1174" mass="127747" checksum="B1120D6E323DCDE5" modified="2018-10-10" version="1">MDSQDGITVRPMRLKVLYTFDDANKTNCLARWPHLLEIQTAFLDEKTQIGVIELKTCIQAIVSASPELVAKLGQDYTVYAYDYSEYETPLVGQGMLSWVLASASPTPDAPAHQSETMVTGRVCKNVLGLFSKGAQETLEVKLRLVPVPTVMQSEYLDSMQRYRELSNVIPHEFDAQAWTNFLRQNPGLLAPRLQQPDRTSSPVDHAGIERFHRLLSEGSTPRELPSFAANGSIRSVSPSQSILGHASRMTTPAASGQQQEQALQLHQPQERSHTDVIRPSSSASMRESDLPSQARFASRRGSMQSGYGSGDESSEQQPRKRAKLYRADWPGKSDLNIERQPSSLRVAASTAASVRIHRPTPVNPSIATAQSSNEEPVRPPTPISHGSDLPRRARPPPSLLRESASTQSHGQYMSPYAMSDDQAPGDHTQSPEESRYQGLFEPSFNMPSSPPVLDCGFPSRSSPVLPPMATDPDSGFMSGGMDDLLDEDMGTPLDDCTRSASHDAARGKRSVRPAAPASSPVGPMNHDNYPASDAPDQPAKEKASAVPRAPASAAGSRPSSRAGIRQAPKPLAPAPMSQSELEQLMSVIPASDPVMPSHVHMQGTQSWNGPMSDFSVAETPAPPPPTEDGKVRSGAGARRLRQVQARLDKCIENGQVPPYCENCGAIETPTWRRAWSKEIDGSEEEANELVKDPTMLFWQAVDRNDEEKVTKFKIYKKSLVDTDKDFVQVLLCNPCGLWLHKFKAMRPENKWNKSSNNKRKRPPRNRKGGGPLSSNTASARSRARADSSKPDGSSPGASDASSPPVDDGTTPRGETENNENEPTTVPENDEVQELPAKRRRANSLEPRKSSDTAGSRWQEQDPVEALRAAIQSSPARNLEHRNASAAGENALTPKSVRRVLFPNSGNEGGPLRTLGEATLNSPRRSPRASRGSDKQPDDKENQTSAELDGLFESPDFDFDLPTSPTPRRRNPRANILGEKRLSLPSNSPSRSRKTISSDATPTRITAQRLQRIQSSPGPARNSKTPKQSRSQGLGLPALAEDAFSTDAFEGMDNMIVDIFSDAPSAHTDALFALDSNKGNWPDWIPSDYVSPTGTDGEPTSGEPAEDTGDLINALLSDPDLQKDPQFDIFGYVDTTVLDSGFFSSDALNADSVALSVKDKGESLKEKQPQPTTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7D4</accession>
    <name>A0A317X7D4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Quinate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_553937</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470862.1">
        <property type="nucleotide sequence ID" value="XM_025613682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7D4"/>
    <dbReference type="STRING" id="1450535.A0A317X7D4"/>
    <dbReference type="GeneID" id="37115825"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="12"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY94101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="519" mass="56798" checksum="A85E3D90BE3A70F0" modified="2018-10-10" version="1">MGLFKNYRVYILTAVAYSGSLLFGYDTGVMGSVLSLDSFKEDFGLPTGSSGFASSKNSDISSNVVSLLTAGCFFGAIFAAPLNERIGRRYSLMIFSFVFLIGAAIQVASLHSIGQIYGGRVIAGLGIGGMSSITPVFVSENCPPEIRGRVSGMFQEFLVIGSTFAYWLDYGVSLHIPSSTKQWRVPVAVQLIPGGLMLIGLFFLKESPRWLTAKGRHEEALQSLAYIRNEPANSEMVQTETAEIRAAIDDEVAATEGLSFKEFLQKSNLKRFAFAFVLMFSQQWSGTNSIGYYAPEIFQTIGLSATNSSLFATGVYGTVKVVATAIFLFVGIDRWGRKLSLIGGAIWMASMMFIIGAVLATNPPDTSASGVSQASIAMVVMIYLYVIGYSASWGPTPWVYVSEIFPTRLRAYGVGLAATSQWLWSFVVTEITPKAVHNIGWRTFLMFGIFCVFNGVFVVIFAKETKGRSLEDMDILFGGVNEADRRAAVENTMHKRGSTHIEDLEDEEADRVRHEQDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8K2</accession>
    <name>A0A317X8K2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_457448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471292.1">
        <property type="nucleotide sequence ID" value="XM_025607744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8K2"/>
    <dbReference type="STRING" id="1450535.A0A317X8K2"/>
    <dbReference type="GeneID" id="37109887"/>
    <dbReference type="OrthoDB" id="68575at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF419">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016397439" evidence="1">
        <location>
            <begin position="18"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="468" mass="50556" checksum="DF6C9B02449632E4" modified="2018-10-10" version="1">MLATSFLSLASATGAMAAAIHTRNQFDASAYAADDIIERDFAIIGGGAAGTYAAVSLADQNHTFTLVEISDRLGGHTRTFHDPATGASVDFGVQIHLDVPIVQDFFTRLNSSLAAVELSSFGTPKYYDFTKQVALPNHTAGTMQSDYVTLLNKYPYVDDLVNLPDSVPSDLLLAWPEFAQKHNLSQGSTEAGLAWPATPGDPLSTTALAILNDGNHIELAEDEGGAVHNANNDNSQIYTNALAEFQPHILLNSSIVAAQRGLNRSSGVQLVASTPEGKKLIKAKQLILAMPPVLDNTKSFNLDTTENSILGKLSGKYYYGGVVNNTGLEEGIAYTNVGVDRPYNAASLPGVVEIAPSAYSGYQFYWYNTEVATTQEEVQAAAKSTIQWLQTQNNVTTSEPNFLDYQDFSPFHLSPPNEDVEDGWYTKMKGLQGHRNTWYISSLFVVGSTQVWNSTNILLPDIISAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X923</accession>
    <name>A0A317X923_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endo-chitosanase</fullName>
            <ecNumber evidence="11">3.2.1.132</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_614492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Chitosanase catalyzing the endo-type cleavage of chitosan, the deacylated form of chitin. Chitosanase may be crucial in the degradation of the deacetylated portion of chitin in the fungal cell wall. Chitoolisaccharides produced by the hydrolysis of partially N-acetylated chitosan are known to have many biological activities, including antibacterial activity, immune-enhancing effects, and elicitor activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Endohydrolysis of beta-(1-&gt;4)-linkages between D-glucosamine residues in a partly acetylated chitosan.</text>
            <dbReference type="EC" id="3.2.1.132"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 75 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.132" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470179.1">
        <property type="nucleotide sequence ID" value="XM_025616740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X923"/>
    <dbReference type="GeneID" id="37118883"/>
    <dbReference type="OrthoDB" id="4756206at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016977">
        <property type="term" value="F:chitosanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009939">
        <property type="entry name" value="Chitosanase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42061:SF9">
        <property type="entry name" value="ENDO-CHITOSANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07335">
        <property type="entry name" value="Glyco_hydro_75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016188784" description="Endo-chitosanase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="239" mass="25226" checksum="EFDA43CB5DD4F63E" modified="2018-10-10" version="1">MHPHFTTTISIWLSSTTTALTYSIPSNLAQIYNDHKSTHCTKPLATGFTDGQTSSPTFTYCGDIPNAIFLHSSSNQYDNMDIDCDGTNPNSGNCGNDPSIQPQTTFQDQVSQYGISDLDANVHPYVVFGNTDFDPQGSGMEPLSVMAVVCGGEVVYGIWGDTNGGDATGEASIALAELCSPGTGITGDNGHTADDVMYIGFTGKEAIPGNTADWMAGNKEDFEDSIRGIGERLVGGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X958</accession>
    <name>A0A317X958_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rcd1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_606212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471857.1">
        <property type="nucleotide sequence ID" value="XM_025616513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X958"/>
    <dbReference type="STRING" id="1450535.A0A317X958"/>
    <dbReference type="GeneID" id="37118656"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000014">
        <property type="entry name" value="Cell differentiation protein RCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="299" mass="32965" checksum="98428F060DA33417" modified="2018-10-10" version="1">MGGDGALPGAVSVMDGGISDENRKVFIWVAELLDPNRREAALMELSKKREQVPELALVIWHSFGVMTALLQEIISVYPLLNPSQLTAAASNRVCNALALLQCVASHNDTRTLFLNAHIPLFLYPFLNTTSKSRPFEYLRLTSLGVIGALVKNDSSDVINFLLTTEIIPLCLRIMETGSELSKTVAIFIVQKILLDDIGLAYICATYERFYAVGTVLSNMVTQLVEQQTVRLLKHVVRCFLRLSDNSRAREALRQCLPEPLRDATFSSVLRDDAATKRCLAQLLINLSDNVSDGAPGVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9C6</accession>
    <name>A0A317X9C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_325050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470978.1">
        <property type="nucleotide sequence ID" value="XM_025606928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9C6"/>
    <dbReference type="STRING" id="1450535.A0A317X9C6"/>
    <dbReference type="GeneID" id="37109071"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF1">
        <property type="entry name" value="DNA OXIDATIVE DEMETHYLASE ALKBH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="191"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="337" mass="37220" checksum="0E9CCD1276D97D01" modified="2018-10-10" version="1">MSKRISSFFQPLPSKKPKVDAAIPAAAPATYTHHPSYPIPIRDPPSTISTRLSNPPPCTPKAITNQPHLDLLYFQPFLPAPLARELFQFLRAELPFYRVKYTIRRGGTPTSINTPRFTTVFGVDDTSTFIPDSTTEDDSQRSAKSRILVDSKTHAPLSDDKKYHPHQPRPIPPCLDVLRQAVEAATDDGTKYNFVLVNYYASGEDSISYHSDDERFLGPRPTIASISLGERRAFLLKHKVGATGEVGNGAGKPLKFPLASGDMLVMRGDTQANWLHSVPKRKGTHGGGAAGVMGRINITFRRAVVPGGTGNYYRYNVGDGVVYRWREEEGKMVAVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9D0</accession>
    <name>A0A317X9D0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_215293</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471726.1">
        <property type="nucleotide sequence ID" value="XM_025606184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9D0"/>
    <dbReference type="GeneID" id="37108327"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="167" mass="19643" checksum="9A89996E9BB73468" modified="2018-10-10" version="1">MEDDGMRGCRARQPARPIACDHYCLTRPQDSKSFCLALRILGFNTIPRTRIYYRNIYLAPVDQIYVITTSTYSDRCNTTTHTVYFRKCSSQWLGPFQLVEKRWSPQIPCLRSFEPWGLRYFRHKDQQIRHRQTQPTQAHEVCRVPKFLNIHMALDGTLLSSCLPLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9M6</accession>
    <name>A0A317X9M6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_458858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471103.1">
        <property type="nucleotide sequence ID" value="XM_025607813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9M6"/>
    <dbReference type="STRING" id="1450535.A0A317X9M6"/>
    <dbReference type="GeneID" id="37109956"/>
    <dbReference type="OrthoDB" id="5412996at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="424" mass="49439" checksum="0D437D2A3D01BF06" modified="2018-10-10" version="1">MQLAKKHRPGKTKSACLWRSGAFNICYRVRYDDDVHVIVRFASLGRAILRREKVENEVATMEYIRHSTSITVPEVFGSGNCWAGPYIVMSFLEGVPLSQILKDPSIEGRPVLNPQISDRSLKWAYYEMAKVILELSKHEFDSIGALAEDERGISIARRPLTFNMNELMASANLPEEVFPLQPFRSATDYFKALAMQHLFHLRLQQRDAVNSEEDCRKKFTARCLFLNLMEKIFPQHPQGPFRLYCDDFRPSNVLVDCDTSRVSGVIDWEFTYAAPAEFTYVAPWWLLLQSPEDWEGDLNQFLNRYSPRLHAFLKVLGDYENELINQHSLSESQRLSPRMQHSMDTGLFWVCLAARYSSMFDEIYWTFIDPRYYGTFTSLDDRIRLLDQEQQRDMNELVRHKAGHCTQDNESFDDHYPIEKLLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA16</accession>
    <name>A0A317XA16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_276756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471253.1">
        <property type="nucleotide sequence ID" value="XM_025606598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA16"/>
    <dbReference type="STRING" id="1450535.A0A317XA16"/>
    <dbReference type="GeneID" id="37108741"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="2">
        <location>
            <begin position="13"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="424" mass="48049" checksum="1E85DF7260D2C78B" modified="2018-10-10" version="1">MMWEYFSDKSILITGGTGFLGTALVLRLSLQAHPKHIYLLCRGGKTRAIQKWREFLPGPLATTLISSESITYLDGNIKYPSLGLADTSLVTLKKEAEIIIHAASSINLVDPLGKLSQSIIGATERLAHIALECPHLQRFVYISTAFANSHLYAESRAVDIPIREELYPLSSIPTATSWKDVQNRGSSEEYEANEFPWDYAYAKHLSERVLAEAFDNAQAYDKLLIIRPSIFGPAQSFPYAGYSVPLSTPLTALAAMVAITPSVWFKAATRARDPDIEVTADEVPVDVVVDRLLFHLRHGSTGYVHAVCGERGRYRFKDLWEDGMAIRKLPWRPRVVWLDVDWHSSQLHYITRFYVLFGPSFNFSEDRTTELWDRVPESERQGLNVYKDYNKGFDLRARIRDIRYCARALASHFGFPSWVGKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAD5</accession>
    <name>A0A317XAD5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_562245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472314.1">
        <property type="nucleotide sequence ID" value="XM_025614275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAD5"/>
    <dbReference type="STRING" id="1450535.A0A317XAD5"/>
    <dbReference type="GeneID" id="37116418"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF11">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="501" mass="54157" checksum="0E3BFB52029F7426" modified="2018-10-10" version="1">MADTEGTDTSTPRAELPRQFTFFSTAALGFSITNSWLGYSGVLSTPLIMGGSPTAFFGLIIASIASCIITAGFAELSSAFPSSGGPYHFAFMVSWPKHRALVTFVVGWLSVISWCTGTASGAIICAQMISSLVAIHYPSFTETTWRIYLIYLLTVLLSAVIVCLLPRAIPRLEDFLFICSLLVFLASLITVLAMQAHKQSAHTVFLVYENHTGWSDGTAFMIGTGTCMYSYVAMDSVTHIADEVPDPGRNVPRAMMTTILTGIITTVPWAIALLFCTTDLGAVSSSPIPIYTAYLQATSSQSVATFFTSWIIFLYGAALLSGLLTTGRLAYSFARSGGLPFSPFFARVTNEVPLNATVAAALFIILYGLIYIVSTTAFNSLISLAIIILNVCYVIPQGIVLLRGRDLALPRRSFAMGKRLGTICNAVSVLWVTVILIFFCFPLRVPTTVHEMNYVSAVITGFVVLIAVGWWGGKRTTFSGPVYVSLSPGLRRMPRFTDGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAP4</accession>
    <name>A0A317XAP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cation channel family transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_542970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471463.1">
        <property type="nucleotide sequence ID" value="XM_025613119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAP4"/>
    <dbReference type="STRING" id="1450535.A0A317XAP4"/>
    <dbReference type="GeneID" id="37115262"/>
    <dbReference type="OrthoDB" id="2373987at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF4">
        <property type="entry name" value="MEMBRANE CHANNEL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="348"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY94702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1123" mass="126344" checksum="9317AB51A6719E60" modified="2018-10-10" version="1">MLASLIRPKKRRVYAERSPFSSPYTTRDSPWPFFQDNPPQGGPGPGYEDFNGYSGIQEEPDAIPGEDESDGDDDGPAESTPLLPIFSASHLDTLPVYDITHAIRPLIVSRCETTLTWDQLRSPQISQFLVKPIQQKIRALHFSRATLYALITNCLQFTKEVHLNPGNSGVSQTRAMVGELLAIKLLREYTTRELIDALSYEFYPLNGQTPTVTASSERAPGWYSAQGSKRPAIARISCLEVAIRAQAKRFLSHPLVVQQLEAIWAGTIVFHSAADNLHRSPAQTQSNGRPQYGTTLDPSSAGASHSQMQSKLSGHRRSVTIYDPRDASLFKLSRLRVPRYRQFLSTLSFAVLLGLFLAVLNQRSLEITPLEIIFWLWSAGFMLDEIVGFNEQGFSLYLMSFWNLFDLGILFLLCCYYCMRLYGAVLPYTRNQGVADQAYDILAANAVLLFPRLFSVLDHYRYFSQLLIAFRIMASDLIAVFLLIIIACSGFFVAFTQAFGSGEDHSPGAVAYALFQMLMGFTPTAWGLWDDYNTLGKVILTVFLFICHFVVVTILITVLTNSFMKIVQNANQEHQFLFAVNTISMVKSDALFSYVAPTNIFAWIITPLRYFIPFRKFVRINRTIIKITHLPILFTICFYEKAVLSSQVIDSSDLLESTSRSESAGRYRARNRRFRAFSSQAHRFVREPSVATYQKDRALDEVFRRPFHDATSRGPGANLNRRESHSAVNKWMQTMGLGPVNPPDEQDSEEVERLERSPRGRSGFQRRLTRSLRDLTESNRSATSDPDHTHQVASSPASPRNGRAHLTPMRTRQLSRHTGMEGDDELTSDDNDGWPEEQRLDPRHSEDDIPRIIKQSPVNTPPKFFSSRPSTARLKSRKTSPARRIKYHTRNYSGVTMLYNPISSDSNHEEAPPSLRPLRPRAETPVHAGGVKVSTSADQWTLRRHSTEGGRLRNVTMTRSDPMSVPDLGGFSVPDSHFQRRRQASILDGLGSDLGDNKAITNGFLGGVPSSLTTQIAYATGNIRRPESPGSSQDMLSKLVLARMNNIEEGFREVIKEVKDLRRGGTSRSQSQIDEQGNVQRENKRRAEKKESKKDAQGSRKSKTSSEGQWSDVPPAEPREKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAT8</accession>
    <name>A0A317XAT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spo7-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_454815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472276.1">
        <property type="nucleotide sequence ID" value="XM_025607621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAT8"/>
    <dbReference type="STRING" id="1450535.A0A317XAT8"/>
    <dbReference type="GeneID" id="37109764"/>
    <dbReference type="OrthoDB" id="5599171at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071595">
        <property type="term" value="C:Nem1-Spo7 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005605">
        <property type="entry name" value="Spo7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28249:SF1">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN SPO7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03907">
        <property type="entry name" value="Spo7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="52312" checksum="89968EC136090618" modified="2018-10-10" version="1">MASASLDQLVKGSPAPSGRLASSTTSSSESLAPPFQTYSPSSDLSSPPRSSTPDPLSTLPSSPPQIYLNLLILESSLRAQYLALRERRRQNTFFLLLLAAWIAYFAYALFLRPREDGRGVGGSVYWVVEMGEKVALMGGVVTALLVWGTGQWERGVRWPRRWLAVANRGLRTMNTKIVVIRGPWWQELFSYLSFLFPFSAPFFPSPVGDFHYVERPVAEKRGSRQHYQQYYNHDTESGLVQEDLSPGGDYIRLLLLPKSFSPEFRENWDEYRSEFWEKENDRRAQLRLKLRQKERQLAQQFGGWFWWIGLGWRASQRRRVAAAAIRPADADKGQHRSHHHHHSSISKHIHEPKSPSRRGTRSESHSRTPSRSTTPVDTDDRPPSRSSVSGRPRRGSTSPGTEQHIQQARKKRGSKTVTRGLTPLTQAQIREGVRTPSFSSDDSSFMGTPSEKEKPKEDGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBE7</accession>
    <name>A0A317XBE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Plasma membrane low affinity zinc ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_542283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471763.1">
        <property type="nucleotide sequence ID" value="XM_025613085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBE7"/>
    <dbReference type="STRING" id="1450535.A0A317XBE7"/>
    <dbReference type="GeneID" id="37115228"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000007">
        <property type="term" value="F:low-affinity zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF69">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="134"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="351" mass="38299" checksum="72BE95BE1D30E28E" modified="2018-10-10" version="1">MEPLHTLVARDSCESGNDFDGRMGLRISSIFVILIGSACGALFPVMARGFKDSKIAKCAFFIAKYFGSGVIIATAFIHLLAPAEEALTDSCLTGPITEYSWVEGIVLMTIVVLFFVELMVMRFARFGHGHAHDDEEDDHHHVEMEHSVSPSPAESVDLKGHMPGEDHLGHSREHHDIEHGKKHSDLEEYMAQLTSIFILEFGIIFHSIFIGLTLATTGSEFVTLYVVLVFHQTFEGMGLGSRLATVPWPKSKKWTPYLLGLGYGISTPISIAIGLGVRNSYASDGATTLIVSGVFDSISAGILIYTALVELLAHEFMFSTSMRKAPIHIVLAAFGLLCLGSLLMALLGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBG4</accession>
    <name>A0A317XBG4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_552993</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471783.1">
        <property type="nucleotide sequence ID" value="XM_025613627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBG4"/>
    <dbReference type="STRING" id="1450535.A0A317XBG4"/>
    <dbReference type="GeneID" id="37115770"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY95022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="478" mass="54358" checksum="7F322A99D1D4C013" modified="2018-10-10" version="1">MAHRYEFGGPLGAAAITFGLPVLLYFFAFNCNDVSGCPVPSLLNPRTLTWDKWAAEAGWPADGIRNLFNWKVTGIVLAYYMLNLLLWKFLPAQQVHGTKLEHHGRPLQYRMNAFFTSAVLLSVCAVGTYLQGAEFPVWTYITDHYVQILTANLLISYVLSTYLYIRSFSVDTNYPNGNLRELAAGGDTGNLIYDFFIGRELNPRVTLPMFGEVDIKTWCEVYPGLTGWILLDLAFIAKQYRTYGYVSDSIVFITCFQAFYVLNGQYNEPGILTMIDITTDGMGFMLSFGDLVWVPFLYSTQCRYLSVYPLQLGWINIAAVSGVFALGLYIFRAANNQKHVFRTQPTDPSVAGLSYIQTKRGTRLLTAGWWGLSRHINYFGDWVQALPFSLPTGVAGYMILPAGSMAVSHGFQMLDGREVIQGEAYSWGLIFTYFYVLYFAILLIHRERRDDAMCAAKYGEDWEKYSRTVRWRILPWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC42</accession>
    <name>A0A317XC42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_319817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470871.1">
        <property type="nucleotide sequence ID" value="XM_025606895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC42"/>
    <dbReference type="GeneID" id="37109038"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016382969" description="Secreted protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11666" checksum="C79B4C2D481A244F" modified="2018-10-10" version="1">MWLLLLLPFPSWLSSMSIISPMVRCDGSPHSISSASTDFSAVVWLRGINGPAREPLAANQRCTWPFHTHHPVQFYRHGPEPEGKLYQNLRMPPSTCRVRSLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCG3</accession>
    <name>A0A317XCG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO94DRAFT_532182</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15 18">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16 18"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470991.1">
        <property type="nucleotide sequence ID" value="XM_025611069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCG3"/>
    <dbReference type="STRING" id="1450535.A0A317XCG3"/>
    <dbReference type="GeneID" id="37113212"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="335"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PWY94230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="478" mass="55267" checksum="B091212BA8B939E8" modified="2018-10-10" version="1">MSAVNSAISHQASMDSKNTSHEISPETSPETSDKKHDDEKITFEFGGAPGVTLAIIGFPLLMYYMYIGATLYDGHLPLPEDNQSISEFLSHLVNLAYTHAYPYREAWIIYWTFLVLEGIGYLYLPGVYGKGKCLPHLNGKQLDYYCSAAASWYVTIVAALVLHFSGLFRLSTLVDEFGPLMSVAICSGFLVSIIAYVSAFARGVQHRMTGSHVYDFFMGAELNPRLFGWLDMKMFFEVRIPWYILFLLTLGTALKQWEDYGYVSGPVSFMLMAHFLYANACAKGEELIITSWDMYYEKWGFMLIFWNLAGVPMSYCHCTLYLANHDPSTYKWNPLALGLLFVMYLFAYWVWDTCNSQKNLFRAQERGKPVNRKTFPQLPWKAVKNPVCIKTKTGDSILCDGWYGMARKVHYSCDWFFAFSWGLITGFNSPFPWFYSAFFTVMIIHRAHRDIERCRERYGEAWREYERRVPYLFIPYVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCN9</accession>
    <name>A0A317XCN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_554099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471071.1">
        <property type="nucleotide sequence ID" value="XM_025613697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCN9"/>
    <dbReference type="STRING" id="1450535.A0A317XCN9"/>
    <dbReference type="GeneID" id="37115840"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016322950" description="N-acetylglucosaminylphosphatidylinositol deacetylase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="281" mass="30967" checksum="131EAC2E5F62A54A" modified="2018-10-10" version="1">MSPSTVLSLGSAVLAVFLFWTLSSTTSSPFAGAFPRLYNKRICLLIAHPDDEAMFFAPTVLALTKPEYGNHLKILCLSSGDADGLGHIRKKELVKSGMQLGLRNESDVYIIDDPTRFPDSMSAHWSESDVSAVLETAFMPESNDSSMKKTNKAAGGSAAPTATIDVLLTFDKGGISNHPNHRSLYHGAVHFLRNMMKDKPGYTCPVTLYTLTTTNLLRKYAGVLDAPDLPSRLLFVSSVNEWMTAQSAMVKAHQSQMVWFRWGWITLGRYMAVNDLKAEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD47</accession>
    <name>A0A317XD47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_620035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472393.1">
        <property type="nucleotide sequence ID" value="XM_025616907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD47"/>
    <dbReference type="STRING" id="1450535.A0A317XD47"/>
    <dbReference type="GeneID" id="37119050"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="4">
        <location>
            <begin position="35"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="330" mass="36141" checksum="A1FF7BBDF8D215CB" modified="2018-10-10" version="1">MGINPLAARVENEVVAMGLARRGLDSFKPGLGDIIPSVYGFCARPDREGDLPWVVMEVKSGVGLDEVFGELEVEMKDDVMGQVADVFAGLRCAVSLGGVGGGVTRGEPWGRYEDLLKGRLRHELGDAEKSVVIRGWKGNGVRERLEGLIERFTLSESGLGLGLEERVLVHGDFTMNNILIDPTTNKLTALLDFDFACIAHPAHEFLVSLQDLGGNIMGPYGEDPTEGKLSQALLSGDFSEDVSGDLWWIGKTLNEKLKERGVRRPCDMMPGMKVLKEWRALEQLICPFHLAAPFIVQKMTEEQRMGARMGAEEELVAQMEVLDGLLGGRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD99</accession>
    <name>A0A317XD99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_529879</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473264.1">
        <property type="nucleotide sequence ID" value="XM_025610545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD99"/>
    <dbReference type="STRING" id="1450535.A0A317XD99"/>
    <dbReference type="GeneID" id="37112688"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000003">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="13">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY96503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="162" mass="16647" checksum="5706DF3079213DDD" modified="2018-10-10" version="1">MADSEYTPKFAPFFSFAGIAAAMIFGSMGAAYGTAKSGIGIAGVGTFRPDLIMKSLIPVVMSGIIAVYGLVISVLIAGDMVPPPDKYMSLYTGFMHLAAGMSVGLAGVAAGYTIGIVGDAGVRAYMQQSRVYVGMILILIFGEVLGLYGLIVGLILNSKSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE68</accession>
    <name>A0A317XE68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_481911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473564.1">
        <property type="nucleotide sequence ID" value="XM_025608873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE68"/>
    <dbReference type="STRING" id="1450535.A0A317XE68"/>
    <dbReference type="GeneID" id="37111016"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="94"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="283"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="365" mass="41489" checksum="6A883211EC8E233E" modified="2018-10-10" version="1">MPTELEELVEFLHHGNTPIRQIACENLVGFSVSQPELFKRHQLLPVRDLKLLVRDYTPIAKNAITILINLSADEEVLASLAEDDTFIETLLAQLTNIKEPNADDVAMLFANLAKSDKMERLLTLKRKIPEAVSNSVNAIDQLMDCFVKGAQGALNKNANFDYLSYLFADLSKFEEGRAYFTSKQAYDDVVPVTKLTVFTEHTSAIRRKGVASTIKNVAFDLPFHPKLFSEDDANILPYILLPIMGPEEFAEEEAMEMLPDLQLLPPDKQRDSDTSIIVTHLETLLLLTTTREGRDKMRAIKVYPIVRECHLHVDDEDVREACDRLVQVLMRDEEGEEKSYQNQIEGKSNIDFTSQDDDQNIEELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEM5</accession>
    <name>A0A317XEM5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_484251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472169.1">
        <property type="nucleotide sequence ID" value="XM_025608950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEM5"/>
    <dbReference type="GeneID" id="37111093"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF4">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="248" mass="28918" checksum="42016D0FC119575D" modified="2018-10-10" version="1">MSSTPAHHIHHLIIQPADAALSPPESYFFIQDGLIITCGILYAFCYIFYMIRTYSDRTYPLASVQGIHFMSLTLAYELYYAVVITTTTFELLGFLVWFLLDVGFVAVALWRVHEKRNRWGIVRRMVGFVVAAMGLLRGLAMVWPDEREQITAYWTGILLQVPISWVCLWTLWKGQSTKGHSLEIWLMRYLGCYAAYAVFFWRYWNVPQNWSYVASVWSVAVIAWTLLLETVYPFVYIWVYQTSKVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFX6</accession>
    <name>A0A317XFX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_571035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473563.1">
        <property type="nucleotide sequence ID" value="XM_025614852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFX6"/>
    <dbReference type="STRING" id="1450535.A0A317XFX6"/>
    <dbReference type="GeneID" id="37116995"/>
    <dbReference type="OrthoDB" id="3544487at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021842">
        <property type="entry name" value="DUF3435"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37535">
        <property type="entry name" value="FLUG DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11917">
        <property type="entry name" value="DUF3435"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="323" mass="36656" checksum="DF63DEFFC6D3C5EE" modified="2018-10-10" version="1">MARRQPKTVDPLSDNSDSSEREHTEDGQYDTDLTEPEDKGSQDRDVSNAALLFADNEHPPEYYIQQLANFDETDYTTEDYGKDTTALLNRVIRQLAKKHKLSTKGRDKPLMDVEDLAKVVETMVSLLRDPQGGPYCIIIEFTFEFTKEWLGVKDVNIYILSEIIFDPSLVLSPYVFLLGLIFADRVFDCVEGISISPDKPLSYVMIEPWVKKIGVIIGFLQVTRLYSLRYGAGTVLDSSGSVSDSLRNLIMHYADICTFLCYYLSRRINKNLPAIIRGLNPEDDIMRAACWMSRSIDPNRLQELITVQSSSVNQDPEIADLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XG93</accession>
    <name>A0A317XG93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_529639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473009.1">
        <property type="nucleotide sequence ID" value="XM_025610488.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XG93"/>
    <dbReference type="GeneID" id="37112631"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="1">
        <location>
            <begin position="359"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1578" mass="175301" checksum="BE879957A5D73D68" modified="2018-10-10" version="1">MTVVTHPRDRHDFHIAIICALPREADAVIALLDHRWDNTEELYTQVRHLGKDSAAGFAIDLRATFPGIQLALVVGVCGGVPSNPHREIEIFLGDVIISESVVGYNFDGQHQIGFLKHAEEGAAGEDIPPSPLQSVLRKLETDNYHSRLQEETRTRLRTLQSQPHGKFHYPGFGSDRLFQPSYLHRHRDTSTCTGCATDNVCMDAIEASCSDLGCDEDNLLHRERTVTSEGLDPIIAGFSPAVHLGQIGSVSTVMKSGSHRDELAHRERFIGLERGGVDLCSFFPSLVIKGVCDYADSHKSKPWQDYAAATAAACTKAFLQSWASDAMETVVDTVGNSPQNDTVEFMVDIHSDDQLVGRDEVMKALADELKTQDRVALVASGGMGKSRVALEYARQFQGTSISVFWIHASTKAMFLQSYEKIARKVSIVGYKASDRDSAYMVTEWFESDSSGRWLIVLDNADDHEVLYGSDRLVDLLPRSKNGSILLTTRDKRVGLDFTGSSSRLLLLDRLNTSHAQDLLVSRLESKPSLEAVRDLVEELAGVPLAIIQAAAYMKHNGIDTGEYLQLYCESPQSQLDVLNEDYDDVLNEQRSNRNPIAATWFISFEYINRNFPVAGDMLKRMSLLESHAIPIFLVVASGKLPPELVKALEILEAFSLITSNARGDTISREQGTYDMHRLVRLATRSWLAQNHELRQWTASTLKILSQNFPSVDSLKWRVVDNYMAYMPHAFALLQSDEIQFIGEDIPSAFVPQQQLKGHAPDGIICGECAAALMLKLAKTCSAFQNHQGAMDWAMQAFKVRQWIFGLEQEGTVQAMTEAVIALYSNKDITKAKELGDLAIKQLDEIEPSPALEAYNYDILGFIGFEDDMNTVLHEHFLQALQIRLQMFPPDHPAVLVTKSNLITAYIREELYPEAEALLKEILPVYNEVYGPMSFPVLQKKSTLSWLYQLSGRVDDALLLNAELSAAHPRRGGDQGHDTIMAMIHSGGVLQDMGRPAAAVDVFQKAMGLIADLQATGTPIELEAITGLSQALTTLGNYADAEPLLVRLVKSCIRVAGDQQITVTAMRRLADLYESWEMCLAAQALREKVAQIEQRHSGRGTVAACLSQCELGLNLIKQGRHAEGKPHLYTALQYPLTADDSGKRENVDRMNSIANGLTDCGFDRGEYFLEAEHVALDAVRLIQPRIRKLPNVAQSSLQSLGFVYQQLGKAAESEEQYQEAINVISGRSHIEWLSPAVMIQCSSVLLQQGKYSAAMSMAAEAVEKLGAHPEPIKVTLARGRANLATAYMEIGNCRSAGSLLVAILSDEYEKAWDPDQSTVSSLLHTFGLIQSVAEVLNGMGRWERSQLIHENMQAIFVQLLGTAHMRTLQTALLLRDTLNYQGKFMDALVLSLECKDRYWQRFRQDTTPEKMMIAQLDSGLAWSYQGLGDHSTAEALSRQALKTNTDITGADSPESLQASTILATILVSQGGPKLMKGSAIQRRAVETWITLAGKNSLRTVRAMEAVAKTCKIQGDEEQYQVWTEKASSAKQSFEPILEEDEKRIDELVRKLFEKWGEDGERVMESMDRRRRKVWTMSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UTQ8</accession>
    <name>A0A317UTQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_570448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000065">
        <property type="protein sequence ID" value="PWY64965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461340.1">
        <property type="nucleotide sequence ID" value="XM_025614812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UTQ8"/>
    <dbReference type="STRING" id="1450535.A0A317UTQ8"/>
    <dbReference type="GeneID" id="37116955"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF279">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY64965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="442" mass="48532" checksum="AB488D71D5640155" modified="2018-10-10" version="1">MPPSNCFPVPNPGECFWQTEPHELNDFRSTEQLPEHADIVIIGAGYAGASTAYHLLRDHGERIKSITILEARGACSGATGRNGGHLRPDFYGHIPTYVDRAGVRAGAEIAEFEISHLHAMKKVIEEENIDCDFTLARSIDVWCNEEAAQKAKAVYERMKSLDLEYMNDVAFYTGKNVEGICGVKGALACASFTAGTMWPYKFILHILKSSLATGKLNLQTFTTATAIKPSTEGGYSIETPAAQFTPAPSSTPTMPTSPKNIIPCKGICCRITVPEGTTAPLLNNSYINRTEDNTLSYLIPRPDGSIIVGGASSKFRPFQDQWYNNVDDSILIDSAKDYYDGYMQRTYRGWENSGAHVDKIWTGVMGYSYDSNPHIGAVPGKNDQFILAGFNGHGMPVIWRSAQELARMVVEKTTQFRIDRAMNGKESDGDILGTGNFPSTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UUL0</accession>
    <name>A0A317UUL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_614205</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000056">
        <property type="protein sequence ID" value="PWY65684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461511.1">
        <property type="nucleotide sequence ID" value="XM_025616726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UUL0"/>
    <dbReference type="STRING" id="1450535.A0A317UUL0"/>
    <dbReference type="GeneID" id="37118869"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="67"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY65684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="421" mass="48520" checksum="F12A13BBBF0EADCF" modified="2018-10-10" version="1">MRFTPPFLHLPVRVQSRRVTIFRSFSRYNHKIANNRAAKPLEEQTLPFYHQKHYYPARTGEKLNDRYRIISKLGYGAYSTVWLGWDDRLKRYASLKICVRDDTERSPVLNEVAMLQRLGTCAQEAENPGLEFTRLAQDIFEIHTSTGTHHCIVTKPQGASIRVLQEVFPNAKLPKLLVKSLIHRLFVSVNWLHATCGLIHTDISPQNILMQLEDDSSLKDLEEQESQNPSTPIISQGIPIYHSRPLTLELSGIPILTDFGQMRPSEPANCDWWMSDLYRAPEVLLQLPWSFPVDIWSIGVMTLELLEGRNLFDPIDPTNDQYVLPLALAQYIGYLGPPPVEIIRQSPLFSMFFDDQGNWISDPPIPQTSLEDFVTTIPPGKEKEAFLRFIRKILTWGPEVRATSVEIIPDEWLMKPWEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVL9</accession>
    <name>A0A317UVL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_629207</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000056">
        <property type="protein sequence ID" value="PWY65675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461502.1">
        <property type="nucleotide sequence ID" value="XM_025617539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVL9"/>
    <dbReference type="STRING" id="1450535.A0A317UVL9"/>
    <dbReference type="GeneID" id="37119682"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY65675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="509" mass="58495" checksum="5D268DF01B84DFD6" modified="2018-10-10" version="1">MKTKRQRAATPRSRTGCQTCKIRHVKCDEQRPECHQCKRTGRKCDGYTQQRPQSDVVPSMKPKLSTDHRIVLRAGSREERHYLYFFNTQTAHALSGFFESELWGRNLPQLSECEPIVRHASAAVSAAHERALALQQHSSGAVRRNNDRFIVYHYNEAIRHLMAYLAFPGEKTDLTLITCFLFVCLEMLSGNSRQALDHMEAGLKIIQRATDQTTGSNATDKELLHLGLRLNIQLAMNGRSMVYFDLESICPEELVNETPVWSNTSQARHALDILMNRTSMFVCLAGYEPTDRTHLEPQQHQLLQEFATWNRAFNALKSKPRRSAKADPRALLLLRMLYLDCWIWVKTCLSRHETVYDSFTSAFAEIVNCAAQIIDIDAVVDRKSTKCAPDMFTLETSIITGLYYTAIKCRNPIIRREAIRLLDQCTKQEGLWNKRVVAKVAQVIMELEEENLSYLPIAKRIPEEKDRIYETVKSIPVGESMQCRRQLVLLSKPNGPDGAWLTRFRFVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWA0</accession>
    <name>A0A317UWA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_614113</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000055">
        <property type="protein sequence ID" value="PWY65955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461534.1">
        <property type="nucleotide sequence ID" value="XM_025616720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UWA0"/>
    <dbReference type="STRING" id="1450535.A0A317UWA0"/>
    <dbReference type="GeneID" id="37118863"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09617">
        <property type="entry name" value="Peptidase_C12_UCH37_BAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000010">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF29">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="8">
        <location>
            <begin position="42"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="6">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY65955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="418" mass="47635" checksum="DF532FCF171B0FC9" modified="2018-10-10" version="1">MTHQLKRRRLIAQPNTVVDDDTGCLDDSCPPASRLEMDGWNGFCELESEPAIFNVMLREFGVKGVKVQEVISLDEEIMATLNKPVYGLIFLFRWREDDPDKQEASCPEGLWFANQTASNACASVALLNIVNNVEDIDLGENLQHFKDFTMPFTPALRGDAISNFDFVKRIHNSFARKMDMLSSDFQLKAEATSKRSRSAKNRNAEDETDAGFHFIAFVPALGKVWKFDGLERQPQALGPCLPEDDWLNLVKPNIRIRMEEYEEDQIEFSILSIAKDPLPELVGQLEVNVKSLETIDRCIKASAEGPPDLGSTIITDSMLGTTVLGPDENYTLTRTMIDQSSIPTAQNSEYQTFSMEEFIQHRQRLSHAQQNLRVLIREEQQSQQADDDYAEGRRYDYDPAVRTWLRFLARKKIIENLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWS5</accession>
    <name>A0A317UWS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_629030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461671.1">
        <property type="nucleotide sequence ID" value="XM_025617531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UWS5"/>
    <dbReference type="STRING" id="1450535.A0A317UWS5"/>
    <dbReference type="GeneID" id="37119674"/>
    <dbReference type="OrthoDB" id="3945550at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="60277" checksum="1DFB41BC1E03E335" modified="2018-10-10" version="1">MLTIDSLPVVVRREIPKFVLEHSWRDLSALSQTSKEWHDIAAAELYKNLRIKFRNLPSLQQDISELCRLWQKKDWASKFVTFRPPATEDSFLVGSLSEFHDSYFGFLTEAEAYYQENDWEPIISLISRLQHLRLFNYIVTNMFPTCLYQALERLHPNCQIDIWTPQSPSLDLPGLGRAHRFVSLGCNQPFDLNILSAPRLHTFHAVYTFDIDPENRQRWVHIDEPFKFIFTAPHLKHLIIDARDGRGENPFLIVKDEWQRFTSESRLSPPTVSLDSLTFIRAPHEPYEHILLNISTMIDLSKFRSLDIGVHSQPAILSQVAPTLVGLERLYIHMLPRNKQFKVHWDSTSEDATWDIEEMISTVQAFRPLRFLCMRGLLSFSSLDRILSHHTTLEGLSLEASYRQRESPPPGEEHKYPISNGDHLRSVAKLCPRLAELRLPVQRTKGNARECDIYRALGHVSQLHTVILDLDCDLRPTPTGELPEPGDREEQLPSPAYIRETLINAAIDEALVKSIFDLILSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXP1</accession>
    <name>A0A317UXP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IID, TAF10 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_529318</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000060">
        <property type="protein sequence ID" value="PWY65272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461397.1">
        <property type="nucleotide sequence ID" value="XM_025610456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXP1"/>
    <dbReference type="STRING" id="1450535.A0A317UXP1"/>
    <dbReference type="GeneID" id="37112599"/>
    <dbReference type="OrthoDB" id="154356at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990841">
        <property type="term" value="F:promoter-specific chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07982">
        <property type="entry name" value="HFD_TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21242:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY65272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="274" mass="27089" checksum="F162093CFC55A384" modified="2018-10-10" version="1">MAESSSSQPPPLAAPSAPSASQETSSVTPGPTLASSSGTIIPKQEPDSTETTLDVPLDQGIDLNPGSLNTMPNANPSDDAATSGNAVPAPTSVDALAAAAAPSKKETSLREFMGKMDEYAPILPDAVTSHYLTLAGLPPPGNGPNQTPPHLARLLALATQKFIADLAADSYQYARIRASNSSSASNPMGSLNAASGLGMPAGAAGVGSAGAAAGVGGGDASKGKAGTHLGIQRPGFGGGGSGGSGQGRTVLTMEDLGMAVSEYGVSVKRGEFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UY00</accession>
    <name>A0A317UY00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_479643</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461606.1">
        <property type="nucleotide sequence ID" value="XM_025608751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UY00"/>
    <dbReference type="STRING" id="1450535.A0A317UY00"/>
    <dbReference type="GeneID" id="37110894"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0349">Heme</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY66151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="516" mass="57750" checksum="35109890395A63BD" modified="2018-10-10" version="1">MAVAAVLSFLQHSIIKSPLQSLAAAAVIVPVLYIIINEFVRAEARVSGLKGPRGLPLIGNLAQIRKNAAEQYRIWSRIYGPVYQIQLGNIPVVVVNSAAAAKVIFGKNAQALSSRPEFYTFHRIVSNTAGTTIGTSPYSESLKRRRKGAASALNRPSVESYLSHLDVESRSFVNELYKYGDGGETPVDPMPMVQRLSLSLSLTLNWGVRVASQEESLFSEITHVEEEISKFRSTTGNLQDYIPLLRLNPFNGSSKMAKEMRDRRDKYLTALNRDLDDRMKKGIHQPCIQANVILDREAKLSSEELVSISLTMLSGGLDTITTLVAWSIGLLSQRPDIQNKAVKAIREMYDQDQPLCDPTDDQKCVYVAALVRECLRYFTVLRLALPRTSIRDITYNGTMIPEGTVFFLNSWACNMDPEVWSDPEEFRPERWIEQPDAPIFTYGMGYRMCAGSLLANRELYLVLMRTLNSFRIEPLGKADWHPVRGNSDPTSLVAIPQKYKVRFIPRGGKALIDALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYP1</accession>
    <name>A0A317UYP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">PTR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_540811</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000057">
        <property type="protein sequence ID" value="PWY65637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461473.1">
        <property type="nucleotide sequence ID" value="XM_025612994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYP1"/>
    <dbReference type="GeneID" id="37115137"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="547"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY65637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="628" mass="70335" checksum="5DFD5DC96A1B445C" modified="2018-10-10" version="1">MNSSDPAEVAEIAKSAVFTHDAHLDEKKDRISAELRQTSSPEIEEIRAIPEKGAAGSSVPYEDDASLQKTFPTYDELKTLRRVAGQIPWTAYTVAFVELCERFSYYGTTAVFVNFIQRPLPAGSSAGATHGREDLVPGALGMGQQASTGLTLFNSFWSYIMPLMGAYMADQYWGRFRTIMFSIAAALVGHTILVISAIPPVIKNPHGAIGCFSIGLIIMGIGTGGFKSNISPLIAEQYREERPFIKTLASGERVIVDPAATVARIYLYFYLMINIGSILGQVSMVYAERYVGFWLSYLLPTIMFTFCPTVLFFCRNKYYLVKPTGSVYLQAFRLWKLAMQGRWSLNPVRLFKSNPTPFWDHVKPSALGSNRPLWMTFDDEWVDEVARGLKACKVFLWYPLYWLAYNQMLNNLTSQAATMKLGGVPNDIINNLNPLSLIIFIPIMDQLVYPFLRKIGFNFTPLKRIAVGFFTAGLSMIAATVTQYYVYERGDCGKQANYCLDEFNSHSPISVWVQALVYILGGLSEIFASVTSLEYAYTKAPRNMRSLVQAVALFMNAFSSAIGQAFVGLSNDPLLVWNYAVVAILAFIGGIGFWLTNYKLDRQEDELNNLPQSHYEGRSENHVDEEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V1Y0</accession>
    <name>A0A317V1Y0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_305798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY68016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462065.1">
        <property type="nucleotide sequence ID" value="XM_025606786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V1Y0"/>
    <dbReference type="STRING" id="1450535.A0A317V1Y0"/>
    <dbReference type="GeneID" id="37108929"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF73">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY68016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="536" mass="58969" checksum="329D3A25027B8904" modified="2018-10-10" version="1">MAIPGDSQDAITAVQPSPRGTGRERAADFLATVDEEQRTFTPDEEKAVLRRIDCRILPLLLGAYFFQQLDKSTLSYVSIFGLVEDAHLHGQQYSWLGSILYLAQLVVQPLAALLLVKAPTGKLIGTAVFLWGSSLAIMAACTNFASLLGLRLTLGVFEAMIAPSCVAVTQMWWRRGEQTLRTALWSGMNGVTFVVGSLFTYGLGHIHSDTLFSYQIIFMFCGLLTVAYSVLVLIFMPDSPMEARFLSEREKVIAVERLRANQMGIISREWRWDHVWETAYDLKTWFWFLLIVSISIPSGGISTFGSLIIESFGYGSFQTILFNIPFGVIQVVAILGGGWLATRFQRKGLVIAGFAAISAVGTLLMLVVPREQKGVLLFGYYLVSCLAAITPLVYAWEAQNTAGDTKRKCTSAVVLIGMCAGNVIGPQLYSTSQAPLYRPGLISNLILFILVGVFAILMNLYLVYLNRKQARKRRALGKSAQIIDESMLSKKTVEQGKAIEVEDVNAPSAEGVSASASDKGFSDTTDLKNEDFIFVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2Q5</accession>
    <name>A0A317V2Q5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_301969</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462216.1">
        <property type="nucleotide sequence ID" value="XM_025606752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2Q5"/>
    <dbReference type="GeneID" id="37108895"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018741">
        <property type="term" value="F:linear primary-alkylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018909">
        <property type="term" value="P:dodecyl sulfate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07710">
        <property type="entry name" value="arylsulfatase_Sdsa1-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.30:FF:000001">
        <property type="entry name" value="Alkyl/aryl-sulfatase BDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.880:FF:000001">
        <property type="entry name" value="SDS hydrolase SdsA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.880">
        <property type="entry name" value="Alkyl sulfatase, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.30">
        <property type="entry name" value="Metallo-beta-lactamase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1050.10">
        <property type="entry name" value="SCP2 sterol-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038536">
        <property type="entry name" value="Alkyl/aryl-sulf_dimr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029229">
        <property type="entry name" value="Alkyl_sulf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029228">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052195">
        <property type="entry name" value="Bact_Alkyl/Aryl-Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044097">
        <property type="entry name" value="Bds1/SdsA1_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036527">
        <property type="entry name" value="SCP2_sterol-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43223">
        <property type="entry name" value="ALKYL/ARYL-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43223:SF1">
        <property type="entry name" value="ALKYL_ARYL-SULFATASE BDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14864">
        <property type="entry name" value="Alkyl_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14863">
        <property type="entry name" value="Alkyl_sulf_dimr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55718">
        <property type="entry name" value="SCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="102"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY68553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="630" mass="69763" checksum="7DCA368152CC2AE3" modified="2018-10-10" version="1">MQQPKDATQFIIDQQKQVRQSLPFDDKRDFVNAGRGLRGRLKPNTIKNSEDDVVWDNDAYGFLENDSPDTANPSLWRQSRLAHLDGLYLVTEGIYQVRGLDLSNTTIIEGEQGLIVIDPLTSKETGTAALALYREQRGTDRAIRAIIYTHSHADHFGGVKGFISDEDVATNDVKILAPEGFLEHAVSENVFTGTSMSRRAAYMYGAALHQGPKGQIGAGLGQTISTGTVTLIAPNVDIKRTGEKKTIDGIEMVFQMAPDTEAPAEMLIYFPQFKALCAAEDATHTFHNILTLRGAVVRDPHSWAKYLTETIDLFGSEAEVVFASHHWPTWGSDNVREFLTFQRDLYAYVHDQTLRLLNKGYNGPEIAEMLTLPPALDQAWNSRGYYGSLNHNVKAIYQRYCGWFDGNPAHLWEHTPVERAKRYVELAGGERELIRKGREAFNSGDFRWAAEVLNHAVFSNPENPDACNLLADVYEQLGYGAENGTWRNFFISGTTELRSGNFGTPTQSASDDVARQLTPDMVFDSLAIQINGPEAWDKKLAIDVVVSDAGVTYRLWLSNAALVYSTAPQPGTADVTMTGTTKQLPALVVYGPHPKALEKAGIQIDGDRSVLHTLSRLLDPGDPDFNIVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3V0</accession>
    <name>A0A317V3V0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_305882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY68021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462070.1">
        <property type="nucleotide sequence ID" value="XM_025606788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3V0"/>
    <dbReference type="STRING" id="1450535.A0A317V3V0"/>
    <dbReference type="GeneID" id="37108931"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016337991" evidence="7">
        <location>
            <begin position="19"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY68021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="565" mass="62461" checksum="786C9AD08CDEB3DA" modified="2018-10-10" version="1">MRSFWFAAVLGALPASQAQFVSPPKDLNATKGYLDIPVRYKQVPTGICETDPSVKSFSGYVDVAENEHIFFWFFEARNQDPTEAPLTVWINGGPGSSSMIGLFQEHGPCGVDSNGTVYNNPYSWNNVSNMLYIDQPIQTGFSYSIPVPGYVDTDTDNVIALPSPVCPDYASDFSCGTYAYPNVSLTANTTDNAAPNFYRALQGFMGAFPQYSRETFHFTTESYGGHYGPVFNEYIEEQNAHLQPGAKKIQLGSVMIGNGWYDPIIQYQAYYNFTVYPGNTYDYLPYNKSISSLLYNNLYGPGNCLDQLYDCAARGIDEVCSTADSFCADEVESIYDNYIGRDEYDFRELTPDPFPYEFYVDYLNKPSVQAAIGAYINYTESSNAVGLAFSSTGDDGRLMNTTDDVAKLLKQNVTVVMYAGDADYNCNWLGGEAVSLKVDAPHFSTAGYTNITTSDGVPHGQVRQAGNFAFVRVYESGHEVPFYQPLLALEMFERVITGKDVATGKIPVSAGLKTVGPLKSTYREGNATIQWEVLDSLATYNTTLNGPNPTSKKQKRMGPALRFQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V404</accession>
    <name>A0A317V404_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_560975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462093.1">
        <property type="nucleotide sequence ID" value="XM_025614191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V404"/>
    <dbReference type="GeneID" id="37116334"/>
    <dbReference type="OrthoDB" id="5366256at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44204" checksum="7216D73BFCA126AF" modified="2018-10-10" version="1">MFSNEFYHSPADSHVRHRPLNESVQQSWRLPSPASAPFVLDLAHLDDSAQLKSSDPPETTVASTLSGWFPGIPSPGSVFSSPRSQRSSISSVEGQSHLSSLHPNQFLARTPFPSELISRDCEPASSPSRLVQRSSPQAIAETSQTSDYQLLPQSMHPGSVAFLTTNMAHNSQNYSWQNRPPQPLHPTSMAMDQQSYPQAHALPPQHAYPAAYQPQHTSSQSYYQPGLPSSHYLSSQPGVPHSRHQPRSSSIPYPYPSASVSGSPPTIPDPSFTSTPPSYLVNQPDYYLTPNSSISQTPNSMPQPHALMPAGTVYSSPDSAPSSSDQDQQVRVISFRPKPQCWDHGCNGREFSTFSNLLRHQREKSGVVAKAECPSCGAVFTRTTARNIHVAQGKCKGIAREPSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5Q4</accession>
    <name>A0A317V5Q4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_590407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462451.1">
        <property type="nucleotide sequence ID" value="XM_025616023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5Q4"/>
    <dbReference type="GeneID" id="37118166"/>
    <dbReference type="OrthoDB" id="5401170at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY69623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="103" mass="11703" checksum="8E3DA3AFAE9F46C1" modified="2018-10-10" version="1">MALHSGSWFDSKWIGKTIDFEPPSSSWQITTKLQEHEARYLQSEFRICGFYSEASCTFVSEDLEGSTQAIMRIRMQIPYLEEDLSSLIPSFDQALAGISGRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6T7</accession>
    <name>A0A317V6T7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_611252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462286.1">
        <property type="nucleotide sequence ID" value="XM_025616625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6T7"/>
    <dbReference type="GeneID" id="37118768"/>
    <dbReference type="OrthoDB" id="10451211at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="252" mass="28345" checksum="0EC1F434AA869573" modified="2018-10-10" version="1">MSERININDYWACRWQQYFPISSGYRFECDPITRNDISLEIITVTRPQRNRITLVMIVGDSRDEAHTPTYNVCLDERVTHYGFTIRDGQLRTFHRPGPTQRVEPWGGEFQEIMDHDQPSDAISRHLEGILSEFRSNGGSASPGLENDPTPGPRQYSAFLNHPWTDDAPTPSMLPSIERHIEDGGSNGVARNSNVRTRDGRRNPPSLQRSEQSLTANAATNVGHHATNGVSTRRRPRAPPPPDSETDDDMVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDG6</accession>
    <name>A0A317VDG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_539592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462812.1">
        <property type="nucleotide sequence ID" value="XM_025612731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDG6"/>
    <dbReference type="STRING" id="1450535.A0A317VDG6"/>
    <dbReference type="GeneID" id="37114874"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY71057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="61" mass="6920" checksum="BCC3BE789578E533" modified="2018-10-10" version="1">MHQCRGARVLWETSMRSVDEPMDMAGWQAGVGAREFLGERMVKEKMDVPDLYTLGMEEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDK9</accession>
    <name>A0A317VDK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_560305</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462917.1">
        <property type="nucleotide sequence ID" value="XM_025614143.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VDK9"/>
    <dbReference type="GeneID" id="37116286"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000031">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001280">
        <property type="entry name" value="Related to 6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000418">
        <property type="entry name" value="Ets_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50061">
        <property type="entry name" value="ETS_DOMAIN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="643"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="857"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="domain" description="ETS" evidence="15">
        <location>
            <begin position="954"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="1227"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="493"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1078"/>
            <end position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY71519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1369" mass="151803" checksum="A585E04F9023BBE4" modified="2018-10-10" version="1">MDTLLTADIVANSPRFRRKSSTFVDAIHDLPEKADLAPAQLYSTESGRLFHSGRIVIITVGLPARGKTHISVALARYLRWLGVKTRIFHLGDYRRATIPYGQDIPDDYFFVNASASSVLLRQKIVKRCREDIYHFLNHENGQIAIYDAVNPIASGRRSLAKEFAKHDIETLFIESWCDDERIIEENVRRVKISSPDYVGWSSEDAVKHYLTRIAARIPQFQTMEETDLNYIKMMNAGERLIVNNRSFGYLSNRIVFYLLNLHIKSRHTYFARAGVSLEAPSYKTDASLSEQGEDYAKKMTECLLQHREAERQAMTEQGEKDYELKPLTVWTSTRRRTVETAKYLHETGYKVRQRSQMSQLNPGVCEKMSERRIREEYPDEVAKHELDPYHHRYPRAESYHDLAVRLEPIILELEREQNDLLIIAHESVLRVLYGYLMACNAADIPFLEFPRDEIIEIIPESYQNEARRIHIPGLPKEIIPGSPEDIKIPVPPSGMTTPLAGGLGSPKEGLATPQSGLRTPREPERISQQHLCPPQGSREAGGAIPALIDKPPVAGTKSQPCEPFDSQYQLATTSPPRTCLILESRLTSFMVSITSEYISVGGNRHPAAADWDVELGVLAFGADNNVALWDPRDSSQRGVYSLLVGHTDKVSVVRFYTCPFSGTKLLLTGSVDHTVRLWRAEPANPHHFVHAHTLEGHTGSVNTIAVADGLDLIASGAADATGEPKGEQLRTIPMKPRFFPLTLALAPLQTESNDRPVALAVAGTTNAVQVYVAENATADPDFKLSAVLSGHEAWQSKTGDLLLASASQDKYVRLWRLQRGEVVPATPACGFEPTLSNKAHQFEAAGSKYSVTFEALLFGNEDWVYTTAWNPDPERQQLLTASADNTLTIWEQDPVSGVWLSGERMGEISVQKGSTTATGSTGGFWIGLWSPDGKQAVSLGRTGSWRSWTYDAETDMWAQSLGITGHVRSANGVQWEPTGGYLLSTSADQTTRLHAQWVRDGLKSWHEFSRPQIHGYDLNCVDTLGPARFVSGADEKLLRVFNEPGPIVQLLEQLSGFKQSTEGALPDTAQIPVLGLSNQAPADDAPAGGDGAEGEEVGKAQANQALLLEANQPPLEDQLARHTLWPEHEKLYGHGYEISAVAVSHDRTLIATACKASSIDHAVVRLYDTSDWHEIRPSLAAHTLTITGLKFSSDDRYLLSVGRDRQWAVYERSKQHISTFSLLTSNPKGHSRMILDAAWAPESGTSIFATAGRDKSVKLWRKNESSFECKSTIPLKTPVTAIGFLSNVYKGYFILAAGEESGELSVYRIAVESLEAIHLSNVDKLVSPSKTITQLSWRPTPEEETGGFALAVASEDTSTRIYSFSDMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDR6</accession>
    <name>A0A317VDR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_476526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462977.1">
        <property type="nucleotide sequence ID" value="XM_025608607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDR6"/>
    <dbReference type="STRING" id="1450535.A0A317VDR6"/>
    <dbReference type="GeneID" id="37110750"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18647">
        <property type="entry name" value="Fungal_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY71579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="601" mass="68339" checksum="1081F7B54FE3A84E" modified="2018-10-10" version="1">MEPQDFTWIRNWAAIGDSYTAGIGSGDLWSERQEDYKCSRYDLSYPVLLKHAIGPQVQDFQYLACSGDRLADIYKQAGELRRMQDLVVLTAGGNDLCLADIIKTCIFLPFQGEQKCQEVLDQAQQNIDTILKPKILELLKKVMTKMNMNGIIIYVLYGQFFNTDNDDCTNGQDWAFPRLDPVHPLRLTRERRAIFNKLVVNINNAIKDVIHGIRPHDNPEPRLRTADWDAFMKDGLQGQYCVPWSTGQYPDPKQPYLHFFKPDTTNSGHYELKKRDLINSISVADDAISALYNSTLYLSPNPSAAVLHDLNPGSSPAPPGCPGDKGPSLGIGLPDRWGKYFHPNELGHRTMASFVLDSIITERSLTLMKPNPTCMRHRDEFRCWQKDGRKDYANPDLLYRNYKTYCAEVKRPKNAKNWKDERWFNSDTPDTHYFSITLSNDATHYDPAHCMESFERIITSCDGNDPENPMNWKFGGRWTRGSYTYELNVQNSFKRPWPPTKKVGGYCDGRFKGLFSHYNMRGRGWSTWDSGQETLVPAIRKCLGLGGLTGFGFKYLDEPDKDGNEWAAWFNTPILFSARCFANNKVAFAAGGFTDGCSGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDR7</accession>
    <name>A0A317VDR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PHP domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_539113</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463210.1">
        <property type="nucleotide sequence ID" value="XM_025612631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDR7"/>
    <dbReference type="STRING" id="1450535.A0A317VDR7"/>
    <dbReference type="GeneID" id="37114774"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000053">
        <property type="entry name" value="Ribonuclease P complex subunit Pop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="245"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY72436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="299" mass="32328" checksum="986132809C9D939C" modified="2018-10-10" version="1">MFYDLNLPYGSDDPEIAPTLSFLAELGYTTVALSQTVSGKLPPNPTPPPAPKNAPKGLTLLTRLNLTLSDPTQNQRLTSLTQAYDLVALRPTNEKALLNACTNLDCDIISLDLSVRLPFHFKFKMASAAISRGVRFEICYGPGVTGSGLDARRNLIGNAMSLIRATRGRGIIVSSEARRALAIRAPWDVINLACVWGLSQERGKEAICEETRKVVALAKLKRTSWRGIIDIVDGGDVVKVDAKTDVSAKSQAKDDAKGDGLKRKASVGSEQTGEEAEKPLSKREMKRRAKKARLEAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDW4</accession>
    <name>A0A317VDW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_560435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462857.1">
        <property type="nucleotide sequence ID" value="XM_025614153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDW4"/>
    <dbReference type="STRING" id="1450535.A0A317VDW4"/>
    <dbReference type="GeneID" id="37116296"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY71102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="364" mass="40982" checksum="27A5856C3C7F9D5F" modified="2018-10-10" version="1">MALTSRGAQMISIVSVLVGLSLLSVILRVVARIKRKVKFGMDDYLCFACMFLLFVMLIELSLWATIGGSYGFDRKFLSKEKMINFYKISLSNEFTYFLIGPTIKVSVICFYRRIFTIPIFQRMSFSLNALIILWGAATLLVCAVQCRPMRAYWDPSIPRQCIDSYKLIVVNQIFNVIMDFVILALPIPMIWNLHRTWQDKLALSGAFALGVFVCFASIFRVVVLFWVNAGNMTYTVYQATLWTHIEPSIALICSCLPTIRGLFPQFKLPSQRRRRYDPEAPHSDVSTSHFVASGCKTQAAAVKNEYYRMEEGVGAAAAAAPSGSVASSRDRAQSSSAKTDTSWLDITVRTDINIREDKVSQIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGU5</accession>
    <name>A0A317VGU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_262546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462825.1">
        <property type="nucleotide sequence ID" value="XM_025606501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGU5"/>
    <dbReference type="STRING" id="1450535.A0A317VGU5"/>
    <dbReference type="GeneID" id="37108644"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38788:SF3">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="38"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY71070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="292" mass="33562" checksum="D810C4F3E7EAFE5E" modified="2018-10-10" version="1">MMDGSIPPPSSTTTTTTTTTTTTIPTSSSPTVFRPRKSEDWNEYRPFIEHLYRDNQLKLRDVKRIMERDYNFVASEKQYKDRLAAWHVRKNIKAKEVHVMIRKQQKRATRGKQTAFRVAGQEVDSKRISRFVRRYGANMETNNAREDPQLSPQGHQIIQQVHQIQQIQQSRQIQTTSPEPETPSDMSYFTPPPDERAMTLSPTETKSQFLRNVEISSTRSLSVSSGTMSNDLSKPMADALQGPDGWMTLEMFQEKLLKLSRTLDQSMSRFVPAEDRSHQSSNSDQYPRSSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHG7</accession>
    <name>A0A317VHG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_434249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463558.1">
        <property type="nucleotide sequence ID" value="XM_025607487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHG7"/>
    <dbReference type="GeneID" id="37109630"/>
    <dbReference type="OrthoDB" id="10343983at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY73806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="109" mass="11786" checksum="FCD47255F109F1B9" modified="2018-10-10" version="1" fragment="single">LSPGCCPNFLLHGSHCHALASTRRAGGRQMVASSFVLLASMTVVPSGSLCKLSLTGTQIRQMGDFSGQPTCTFLIWAVWSISVSRQFYPKAALLYFIIICPFQNLSSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIJ0</accession>
    <name>A0A317VIJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chord-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_500844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463484.1">
        <property type="nucleotide sequence ID" value="XM_025609419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIJ0"/>
    <dbReference type="STRING" id="1450535.A0A317VIJ0"/>
    <dbReference type="GeneID" id="37111562"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="129"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="204"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY73219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="311" mass="34220" checksum="B2F3797E74CA35C7" modified="2018-10-10" version="1">MASKCVHKGCGKEFTDAEEPCVYHPGPPVFHEGQKGWKCCKSRVLTFDEFLAIPPCTTGKHSIVDDTPVELKPKPVAEEPAAPAPAVESAVPRPAISPAIPPPSNAPTPVPEEPESDDPDVEIAANATCRRKGCNTGYDATIPREQEKCVHHPGQPIFHEGSKGWSCCKKRVLEFDEFLKIQGCTEKTKHLFVGKGKPPGEEKVETVRNDFYQTPSSVNVSLYLKKINKETAKVEFAATSIGLDLPTTDNKRYKDTYQLFAPIDPEKSQFRVLGTKLELTLVKADGTSWPVLRSDDKWSGERIQIGKAGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKN0</accession>
    <name>A0A317VKN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bax inhibitor family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_500276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463533.1">
        <property type="nucleotide sequence ID" value="XM_025609410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKN0"/>
    <dbReference type="STRING" id="1450535.A0A317VKN0"/>
    <dbReference type="GeneID" id="37111553"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF112">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY73781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="36774" checksum="D277B07D0DD663A0" modified="2018-10-10" version="1">MAFFMRRPFAVPTALRQISKPANSARFIHNTPFKPSQPKPTGPVSIFAKSRQTFQNAFRRTYMQPSYNVQGGNLTQKLLYGATIVGGTILATNLIFNRETREDGGMPPFERSFLNETFLHTGLGVGIIGIAARALHMNGWSYRLMAASPWAVIGLGLVASVGTMYGTLYTSPDNYVVKYGLWTAFNITQAALLSPLMFMNPAILARAGLYTVGMMGSIAFVGATAKQEKYMYLGAPLLAGVTIVALSGFAPLVLPATATRALMWSEKIWLYGGLAVFGGFTLYDVQKILHHARMAERGLVRKDVVNEAISLELDFINIFVRMVQILGMRNNNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VN12</accession>
    <name>A0A317VN12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_559596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463942.1">
        <property type="nucleotide sequence ID" value="XM_025614082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VN12"/>
    <dbReference type="GeneID" id="37116225"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY75315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="564" mass="60756" checksum="F0CA650115EB582C" modified="2018-10-10" version="1">MNSAKHSQTTLPAQSVSVTEKSTAEDVQLPRGGPPEEIPDSKPDEPKWIKGITLVMVMTAVTLVVFLMLLDVSIVSTAIPHITSEFHSLDDVAWYGSAYTISSASLQPLTGKFYSNFQQKWTFLGFFGVFELGSLICGVATSSKMLIVGRAVAGMGSSGMVNGALNIIASSLPMHRRPTFMGIMMGFSQLGLVLGPLIGGAFTTYSTWRWCFYINLPIGGLVAILLVFTSIPEPAGKPKVGEVFRSVLLKKFDLFGFVLFAPAAIQLLLALQWGGSKFAWKSSTIIGLFCGSAATFFVFGLWERRMGAEAMIPGQMVKQRIIWSSCMAMSMMFGMTMILAYYLPIYFQSVRGKSALTSGVDLLPQILCQLVMAVASGILTGKLGYYLPWAIFGAILTPIGCGLLATLSPTTAVRDWAGYEALIGFGRGAATQVPMIAIQNAVSPNQISTAMAILTFSQTFGGSIFLAVAEVIFTAGLRKKIPEYAPSVSPETVISAGATGFREVVPAKDLLSVLVAYSKAIDEVFYLGAALCVAQFIFSWGMGWKNIKKGKQEKKSTENIKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VP04</accession>
    <name>A0A317VP04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_231386</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463791.1">
        <property type="nucleotide sequence ID" value="XM_025606299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VP04"/>
    <dbReference type="GeneID" id="37108442"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016386908" evidence="2">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY74598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="339" mass="37956" checksum="7626F89D76A82B14" modified="2018-10-10" version="1">MGRRIHGFCDSLLFWTVACLFTVMIQAPEQVDPVAPANNLVAVGGEMVMRSPPVTMMGSARVGLHQSIHADFIHCPYMRSRWIVSAAMGKRKQCGTENSDCRRDTLRWIRKAGQRISCRSAFLQDHRRGQWAPIMRFHSLDWSVIITQNNCSWKAQDGRSCSKIGTGKKKKKKRVTIEWNPDPFSFLSFQSFHIDHFFFLFTSHFYSFLFFTRITSRVADTVSPFPPPPPVNSIALSTVDLNYRRDPLLGGLHSISGRPQHRYSNSAPAVDGAATFLPGSCRRRICPIRPILASALSTFYSSAIISIIIIIILLSSRALSTLTQPTLQATPTIGILSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VP24</accession>
    <name>A0A317VP24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IDI-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_538503</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464121.1">
        <property type="nucleotide sequence ID" value="XM_025612504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VP24"/>
    <dbReference type="GeneID" id="37114647"/>
    <dbReference type="OrthoDB" id="3660930at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016388495" description="IDI-2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY76124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17184" checksum="FEC8D5CC5087BA1D" modified="2018-10-10" version="1">MKFTIALFSMLALTSAISSPTAEGAECGDLDIMAVSKADLPEGVSPSDVRKCKDHPLGRNRSLEGASLAPQDDIDPSLSINTTATSEVEARSDLNTLGERSCYSAAPYGCSKGYCWKACGENGEWCWTARKAGVGAWYTCSTYKDCGTTTYACGVGCPSCGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTS1</accession>
    <name>A0A317VTS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_201906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464230.1">
        <property type="nucleotide sequence ID" value="XM_025606104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTS1"/>
    <dbReference type="GeneID" id="37108247"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="190" mass="21388" checksum="6BF4FD3C7A55E113" modified="2018-10-10" version="1">MAWAAEGTGAPSDSLDESLSVLLFSSTFVFRLSRSLSLSPWSSTSCQSRPNPPSKARHHPRCHQLSKRKEKAGAVYILILSQSNITYRKSQTPNPMHRTDPIYIDAGGSRYQLGETPASSACKQTQQRETERRRPNMNVPPMQIYVQAMYLYLNRSGTLRKFPVCQQRDATSRNERKGGEEAKDPPSEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W279</accession>
    <name>A0A317W279_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_536960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465338.1">
        <property type="nucleotide sequence ID" value="XM_025612159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W279"/>
    <dbReference type="STRING" id="1450535.A0A317W279"/>
    <dbReference type="GeneID" id="37114302"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12163">
        <property type="entry name" value="2-Hacid_dh_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333">
        <property type="entry name" value="2-HACID_DH_C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43333:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="117"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="3">
        <location>
            <begin position="226"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY80736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="352" mass="39163" checksum="8EA7C12CA1A0F44B" modified="2018-10-10" version="1">MASREFLLILMPWTPPAEWVSGVIDSIPNIRIEIFQIDRSAAELPAEISLEVWKDVTSLFTWKLFPTKELAPNLRYVQLLSAGCNHANELPLFQEPEVALCTANGVHPPQITEWVFMTFLAFQHHLPQYLKYQKVGKWVDPVSDEDTEDAVGLRVGIMGYGSIGRQCARVAKAFGMDVHAFTMRPRATLASRKADTFSEPGLGDAVGEFPSRWFWGKDQLNGFLSSDLDLLVITVPLTRETRGIISREQFALLSKKKTYVSNIARGAVINTEDLVAALEGGQIRGAALDVTDPEPLPADHKLWGFKNVIITPHCSGNSTHYNERALKILASNLERRAHGKGLINQVDKALGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2D2</accession>
    <name>A0A317W2D2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_470403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465398.1">
        <property type="nucleotide sequence ID" value="XM_025608333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2D2"/>
    <dbReference type="STRING" id="1450535.A0A317W2D2"/>
    <dbReference type="GeneID" id="37110476"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016193157" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="159"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY80796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="678" mass="74482" checksum="F5D51BB6314554D8" modified="2018-10-10" version="1">MGAMASLLMVLARAKASSASTTLLFQNDGNWTAHAERPSGLLVHSPARRNQAGAICAEYGEQLLDCADVGAFRQSLQYQQYLGTFSNDTLLWTACTAPVALTGHPLSENASSSDEWPFVCTNSAPLVDRVDTDYSSFPRVNATAGNITFEGLRDHLTFRFAGLPFAQPPLGARRFQYAEAWDATNVSYVNATQYSPACLQFGYFEGNSYGLNPWGNDEDCLYLNVYTPFLPGADVSDDQLKPVLFWIHGGGFSQGTGSDLTFDGGSLSSRSDVVIVTSNYRLNIFGYLSLDDGIIPGNYWMSDNIAALQWVQQYIRGFGGNPNNVTIFGQSAGGTDCIELVASPQAAGLFQRVIQQSAGNGRFSTQKAISELAQPYISPHCNGTGVSRLVCLQELPASVLLNDSADIFFTPVIDPMYLPDAPMALIAQGSSYINSVPMMTTMMPEETQSLTTTMLAPNMTDFQAALYLLVPGGWINQNQADHIIPSGLWLISNESFHNGSVSYPSVYNASIKISTENNQECPNGAYAMVGASTVAFPSIHVAYHQRGYALSYYDFYDLCTFPVGKPDTPYYRCHSSDLYEVFGTYYIFDQPIRVQEDIFYTNAVQDMWGSFARTGNPNVPTDYLAARGYESTIAFFADWHWPEFTASDMVLANLQYPEPGYTNVPDLAHCRYLAKVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4P9</accession>
    <name>A0A317W4P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_520310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465664.1">
        <property type="nucleotide sequence ID" value="XM_025610102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4P9"/>
    <dbReference type="STRING" id="1450535.A0A317W4P9"/>
    <dbReference type="GeneID" id="37112245"/>
    <dbReference type="OrthoDB" id="5283654at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY81596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="313" mass="33723" checksum="F7CF59780649438D" modified="2018-10-10" version="1">MVFNRIAVYGHRGWASSAIVRALASSGAFIKVLYRPGSDISTLPNNVTTVEVDVEDQYALVGALKGIDIVISLVGHEGVSRQHHLVTAITKSDVQLFVPSDLAARYDEQGMRIPVNHAKGTVETAAKEAGIATTVVLPGNFAEFALSTGAMGVDYKQNRFIYTGESAIKPLNLCTKAYVAAAYASIFASTPIEKIKNRTLALCELSPTGDDIVAALTEKFGSRTLTTAETIESINDKVETALSTGNPFALAYYCRKIWGSGQQAAMVGTDMWDLEQYPKASLRGLIVDGQLGSYRGLPVEVEQFFASHFELCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5Z6</accession>
    <name>A0A317W5Z6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_148990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465334.1">
        <property type="nucleotide sequence ID" value="XM_025605791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5Z6"/>
    <dbReference type="GeneID" id="37107934"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY80732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14497" checksum="8050A96F44AB822D" modified="2018-10-10" version="1">MFQRGGHGHQEKEPGGSRSSSEAGWTVVPSGRDPTAEIPRPPLSLSGFGTHPLLRPIMAAQLEPRLARSCDHCKAKKIRCLRPLDSVTCTPCLNRNIECHYSLTRRRLKPKEARASPSLRTTHKLSQVTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6L3</accession>
    <name>A0A317W6L3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_576565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465663.1">
        <property type="nucleotide sequence ID" value="XM_025615142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6L3"/>
    <dbReference type="STRING" id="1450535.A0A317W6L3"/>
    <dbReference type="GeneID" id="37117285"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="36"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY81595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="161" mass="18573" checksum="E09F2812643B57D0" modified="2018-10-10" version="1">MNPLPKEYHFTHPELSYDSEPNFQPAIKVSLFFSKKDEITHEEFFRHWRTVHADLAVATQAFQHKVLRYVQHHQTPEMKARMTSIGASVLDYDACAQLWVRDWDSWLEFCQSPEYLAALRDDCDRFMGSPIKFMVGYETLIVGDASRVIGGKSGLSTKATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8M4</accession>
    <name>A0A317W8M4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_163425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465329.1">
        <property type="nucleotide sequence ID" value="XM_025605884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8M4"/>
    <dbReference type="STRING" id="1450535.A0A317W8M4"/>
    <dbReference type="GeneID" id="37108027"/>
    <dbReference type="OrthoDB" id="5401170at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="76" mass="8841" checksum="EE170FB0A0E203E5" modified="2018-10-10" version="1">MEGKEFFSDSFINKTITFSSPDSHYRLIKKLREFNDQRDPEMFLNSPDKPGGAYGTFLCSNTVNPTEEKIMRIIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9H0</accession>
    <name>A0A317W9H0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Exo-1,3-beta-glucanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_123378</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. It could also function biosynthetically as a transglycosylase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="13"/>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466049.1">
        <property type="nucleotide sequence ID" value="XM_025605589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9H0"/>
    <dbReference type="STRING" id="1450535.A0A317W9H0"/>
    <dbReference type="GeneID" id="37107732"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF1">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE I_II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016292465" description="glucan 1,3-beta-glucosidase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="91"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY83264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="386" mass="43066" checksum="ADF5A6A229DEC73B" modified="2018-10-10" version="1">MYGLLGFLAALGCVPPALAAPLTTPQKSAYIDWRTFQANGVNLGGWLEQESTIDSHFWATYSGGASDEWGLCMHLGSQCGPVLEHRYATWITKEDIDKLASGGVRILRIPTTYAAWLKVPGSQLYSGNQTAYIKEIADYAISTYDMHIIIDTHSLPGGTNGLTIGEATGHWDWFYNETNFNYSMQVIEKVIDFVQKSDSPQSYTIEPINEPADNNTNMIVFGTPVALTDHGAAWVLKYIKAVVQKVASVNPKIPVMFQGSFKYPQYWEGDFPADTNLVFDVHNYYFENRPTSSANLPEFLYSDARTKSGSGKFPVFVGEWSIQATYNNSFALRKRNVNTGLAAFGEYTQGSSYWTAKYSGNTSVDGQGEQRDYWNYEAFIDAGYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9J2</accession>
    <name>A0A317W9J2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_470494</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465372.1">
        <property type="nucleotide sequence ID" value="XM_025608337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9J2"/>
    <dbReference type="STRING" id="1450535.A0A317W9J2"/>
    <dbReference type="GeneID" id="37110480"/>
    <dbReference type="OrthoDB" id="5152799at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.160:FF:000004">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF6">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY80770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="509" mass="57732" checksum="4EFAD8CA398ABE51" modified="2018-10-10" version="1">MVHLSTVAKESHGHRRQREELDAQAAAVSPYVYGTRYAIEELPEHTMSEHEMPASVAYRMIKDELSLDGNPLLNLASFVTTYMEDEVQQLMSDAMSKNFIDYEQYPQTAHIQNRCVNMIAGLFHAPTINDPTNEQDAIGTSTVGSSEAIMLAMLAMKKRWQNKRKEAGKDWSRPNIIMNSAVQVCWEKAARYFEVEEKYVYCTDTRYVIDPKEAVDLVDENTVGICAILGTTYTGQYEDVKAINDLLVAKNIDCPIHVDAASGGFVVPFVNPELEWDFRLEKVISINVSGHKYGLVYPGVGWVFWRAPENLPKELIFNINYLGAEQASFTLNFSKGAPHVIGQYYQLIRLGRHGFRSIMTNLTQISDYLAAELQKLGFIIMSDGGGRGLPLVAYRLPEQEDRLYDEYALAHVLRRRGWVIPAYTMAPKSSQLKMMRIVLREDFSLHRCNLLVEDIRLALKTLEEMDETMIKRYSTYIQTHATRGPQGHPVYGNEQHSLQGKSGKTHAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBQ1</accession>
    <name>A0A317WBQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arginine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_587271</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465628.1">
        <property type="nucleotide sequence ID" value="XM_025615815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBQ1"/>
    <dbReference type="STRING" id="1450535.A0A317WBQ1"/>
    <dbReference type="GeneID" id="37117958"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="68"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY81560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="565" mass="61815" checksum="384AAE4E0722DE96" modified="2018-10-10" version="1">MADKEVTSPGKATFGNAVTEQDGSNASSDQNSIQSGLRERRRNGLTKDVESDNEEDETKLKRNLKNRHLQMIAIGGTIGTGLFISSGTALAEAGPAGALIAYAFVGSIVYSVMCSLGEMATYIPITGAFTSYAARLVDPSLGFAMGWIYWFNWASTYAVELTATGMIVQYWNDQLSIAIFIGIFWVIITAINFLPVGFYGELEFWFSITKVLTVLGFMIFAICIDAGVGKQGYLGFKYWHDPGAFAPYLVTSNEAIGKFVGFWAVLIQAGFSYQGTELVGVAAGETENPQKTVPSAIRKTFIRILIFFVLTIFFIGLLVPYTNPELASGAENASASPMVIAANLAGVKVLPSLINAVLLTVVLSAANSNVYSGSRVLLGLAQEGFAPPIFGLVTRRGVPYVSVAFTALFGLLGFMNVSDSGSTVFNWLVNISSVAGFICWTCINASHIAFMKAMKARGASRETLPYKSIWQPWLAWYGLFFNILIIFTQGFTAWIPTFNVSDFWVAYICPILFVILYVGHKAWYRTGFVRPIEADLDTGRPQYTTWESSNPKDGWARRIWDSIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCM0</accession>
    <name>A0A317WCM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_519678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465892.1">
        <property type="nucleotide sequence ID" value="XM_025610083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WCM0"/>
    <dbReference type="STRING" id="1450535.A0A317WCM0"/>
    <dbReference type="GeneID" id="37112226"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY83107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="178" mass="20079" checksum="20FE1C52221B4337" modified="2018-10-10" version="1">MTTTEPLVRVGIAAFVFNASGQILLGKRKGSHGAGTWALPGGHLEFNESFETCAAREIKEETDLNVEGFRTLALTNDIMRRENKHYVTVFLGCVVCDKDVDVVPKIMEPEKCNVWEWTSWEDVRVGFEEEEEEGGDEVDGLMMDRDSRRRLFTPILNLFRQWRGFDPVVSYEGGGVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDI1</accession>
    <name>A0A317WDI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_494052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466389.1">
        <property type="nucleotide sequence ID" value="XM_025609218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDI1"/>
    <dbReference type="STRING" id="1450535.A0A317WDI1"/>
    <dbReference type="GeneID" id="37111361"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000027">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="83"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY84464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="286" mass="32539" checksum="B959C3852DFF5327" modified="2018-10-10" version="1">MPKLSPSTLLTSLFYLLPIYLFVIAPLLRQLFPVTTDIFDPDTDTPDAETDITLDPEILSLPDGVTPTCPEDTYRVHLLSKDPLIIYIEDFLSDEEADHLVKISEPNYTPSIIYNGQTTKVDPSTRLSDRALLPRDNTVRCLESRASSFQGWKPHLYIERMWAQRYNVSGHYKHHFDWAGSVARGGDRLSTFMVYLGDDCKGGGTNFPRLKMPRGDQWCQFLDCEMGDNVTGITFKPVKGNAIFWENLKSDGTGYPETWHAAFPVTEGLKVGLNIWSWYQPPRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WF58</accession>
    <name>A0A317WF58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl hydrolase family 71 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536504</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466330.1">
        <property type="nucleotide sequence ID" value="XM_025612032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WF58"/>
    <dbReference type="STRING" id="1450535.A0A317WF58"/>
    <dbReference type="GeneID" id="37114175"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF33">
        <property type="entry name" value="ASCUS WALL ENDO-1,3-ALPHA-GLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016373922" evidence="1">
        <location>
            <begin position="20"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="468" mass="51166" checksum="34E035E99161AAC7" modified="2018-10-10" version="1">MQLLFTSLFGLFMANQALGAAVFAHFILGNAWNYNLTTWEEDITLAQEAHIDAFALNMGYGDSSLATQAALAFEAANKLDFKLFFSFDYEGGTGAWPQADVLTYLNKYASNSAHYKYNGKPFVSTFEGTANAADWITIKSETNCFFVPDWSSLGAEGALKAGGGGVPDGLFSWGAWPSGPNNMDNATDLTYLDLDIPYMMPASPWFYTNLAEYSKNWLWRGDSLWHDRWEQIWELQPEWVEIITWNDYGESHYIGPIREDALSLMETGGAPLNYIENMPHDGWRHILPFAIDTYVSKNASITDEALVTWFRPNPGHACGTGGTTGNTASQGQTLYAPAEVAQDKIFYSAMLDSHANVTVTVGGKSLGATWDKAPSGAGLYHGGVEYGSATGKVVVTVTRDGETVASVAGESISTTCAETLSNWNAWVGSNVTTTSTKGVASRSLDKGTLEVINRHAHKHLHRGHNHFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH45</accession>
    <name>A0A317WH45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_575790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466811.1">
        <property type="nucleotide sequence ID" value="XM_025615100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH45"/>
    <dbReference type="STRING" id="1450535.A0A317WH45"/>
    <dbReference type="GeneID" id="37117243"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF17">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY85794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="369" mass="40766" checksum="713B939987725E19" modified="2018-10-10" version="1">MVESPEKRPRPRRPKQKGCHECSQRRVNCDRKEPTCGKCEAKGIECSGLGIRVRFCHGVASRGKLVGRDASGEKLPCQTDIPSSSSLRRDPSAIPAVIDPLAQWERILVDYFNKTIAPNMIAVDGEANGYRTLILPAAELYPCVLKAVLASSAHHIALRVAPDHRSEAVVRAHELYTDAISALQQLTTAPTTTHTPNAITSLVLLICTMITGSEDFPFLFRMLSASLSVVNLGHDDQLGPPLYHFLNIQMQKFKLYARPFLLPANDIPQPTDTLLTDGLACLLLCSRLHPEHSARLIQASQLIQIASELYGRRACGEELDSQSSTELVEQFINTLVDYRSTQSLPGRYTPRALRSHGVWEFTGRFACVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH87</accession>
    <name>A0A317WH87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_105717</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466522.1">
        <property type="nucleotide sequence ID" value="XM_025605484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH87"/>
    <dbReference type="STRING" id="1450535.A0A317WH87"/>
    <dbReference type="GeneID" id="37107627"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF11">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY84597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="304" mass="33576" checksum="06074AE876F67A20" modified="2018-10-10" version="1">MSGMNATAAYDFKQQLTEGCHAKIEGYGTSYGYVPSLAAGIVFCTLFGLSMILHMVQLVWKRTWWCAVFVLGCMVEVLGWAGRTWSAECPYNGTAFLMQISTLIIAPTFFTAGIYILLGRFIHLLGPETSILSPKLYLWIFVTCDVVSLVVQAVGGGMASIEVNKVNGNTAPGTHTMVAGIVFQLASITVFVFLAADFIRRTLRQQLLQTMTGTIVPLLGAMIFSVVCIYIRSIYRTIELSQGWTGFLITHERYFIVLDGVMMVLAVGIFNIFHPGWLLPKHGPKAFHREIYSPDGLASGMEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHU0</accession>
    <name>A0A317WHU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SIR2 family histone deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_519326</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466228.1">
        <property type="nucleotide sequence ID" value="XM_025610067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHU0"/>
    <dbReference type="STRING" id="1450535.A0A317WHU0"/>
    <dbReference type="GeneID" id="37112210"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY83760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="318" mass="34613" checksum="AE60988931A2F6CA" modified="2018-10-10" version="1">MAPSAIPAADLKSFGVYLKGCRRIIALLGAGISASSGLPTFRGAGGLWRSYDATELATPEAFDANPDLVWQFYSYRRHMALEAQPNRAHYALAELARRNKDFITLTQNVDGLSQRAKHPPQQLHLLHGSLFTVKCTSFYCSYSREDFADPIVPALALPKNAPKLNPSTQDISGEEASRSLSNALGGDEDMEADISDERIPLSALSTDVLPHCPECKDGLLRPGVVWFGESLPLHTIDRVDQWMNKGNVDLILVIGTSSRVYPAAGYVDKARERGARVAVVNMDRNDVGSSGLMPGDWFFEGDASAVVPKILKEVIGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WIN7</accession>
    <name>A0A317WIN7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_575429</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466917.1">
        <property type="nucleotide sequence ID" value="XM_025615077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WIN7"/>
    <dbReference type="STRING" id="1450535.A0A317WIN7"/>
    <dbReference type="GeneID" id="37117220"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="11"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="121"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY86326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="176" mass="19456" checksum="3BA7C36CF3F78E1C" modified="2018-10-10" version="1">MAELRPLEVEQFERLSSYPFSADREFAVGLSIILGHPELPASEAEINRSDDLTLQAKCFYFSRKEKLTPPLNFSDYKTWLGSAPAGAASLIKTAMQQSNPAGFSSTNHTGDIPKSSEEPAYPSSFAHIVELITTGQPIPGIQQIPDTVLTGHDTPSEKPKRRKPWEKEKGIEDQDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJA0</accession>
    <name>A0A317WJA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative mismatched base pair and cruciform DNA recognition protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_586120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467125.1">
        <property type="nucleotide sequence ID" value="XM_025615739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJA0"/>
    <dbReference type="STRING" id="1450535.A0A317WJA0"/>
    <dbReference type="GeneID" id="37117882"/>
    <dbReference type="OrthoDB" id="5309565at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40460:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="Hypothetical protein YjbJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="185" mass="19463" checksum="0AA25FD5C89C9964" modified="2018-10-10" version="1">MSSNDTTNTTNTSTNTSTLKSYLDQATGVAQRAVGSLTGDSSTQSTGESTQSTGKAEHDASHTTAKVGPVTTDPSTGTTATDHPQRNNGSWDQTVGSAKESLGNLIGNEGLRKAGQEQNQAGKEAEAEGQVRDWGEGVKGRVAGGVGKVAAAATGDEEEEKRWKDVHDEGKVRQRGVERDVERRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJE6</accession>
    <name>A0A317WJE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_493786</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466788.1">
        <property type="nucleotide sequence ID" value="XM_025609209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJE6"/>
    <dbReference type="STRING" id="1450535.A0A317WJE6"/>
    <dbReference type="GeneID" id="37111352"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="17" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="16">
        <location>
            <begin position="13"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY85771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13350" checksum="AC99C72D1CE8A3E9" modified="2018-10-10" version="1">MSFYVAPSQQRTLRACMVCSLVQLHNKFMREGCPNCDNVLGLRGNNDAIQECTSQVFEGLVTLRDPTTSWVARWQRLDSYVPGTYAVKVTGSLPDEIISSLEDSGVKYIPRDGSTGEEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WK11</accession>
    <name>A0A317WK11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_535558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466996.1">
        <property type="nucleotide sequence ID" value="XM_025611816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WK11"/>
    <dbReference type="STRING" id="1450535.A0A317WK11"/>
    <dbReference type="GeneID" id="37113959"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.770:FF:000003">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="8">
        <location>
            <begin position="3"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY86405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="445" mass="48603" checksum="281977584F1F8CE1" modified="2018-10-10" version="1">MSVWNPDNIRDVAESVGVVNLNNDVTENLARDVEYRVAQVLEEALKFMRHSRRTLLTTQDVAQALRVLDVEPLYGYESTRPLRFGEASLGPGQPLFYVEDEEVDFEKLINAPLPRVPREISFTAHWLAVEGVQPSIPQNPTAADSRNLELMSKGPNASSTLAAMSGGGNVTVKPLVKHVLSKELQLYFEKVCNAFLDESSEEYRTSGFASLREDPGLHQLVPYFVQFISEKVTHGLKDVFVLTQVMHMAEALVQNQSLYVDPYIASLVPPILTCLIGRQLGGNAELSEQFALRDLAASLLGLIAKKYSNSSHTLKQRLARSCLKTFLDPSKPFGAHYGAIIGLHAVGGAEGVRVLILPNLPTYGNLLKDGMVEESPRRPEAEKVLAVLLGVLATLREGRPALANGHGGMVTDGLRERLSGKVGEFLAAKISDAGEVDMAHAIVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKP1</accession>
    <name>A0A317WKP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_535171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467262.1">
        <property type="nucleotide sequence ID" value="XM_025611717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKP1"/>
    <dbReference type="STRING" id="1450535.A0A317WKP1"/>
    <dbReference type="GeneID" id="37113860"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36452" checksum="A7274E265FCDA654" modified="2018-10-10" version="1">MTTRKRNEFLDIVASDDSDANDHGYDSEAAEAEKSKGRAVKRRRTQPEPQSQTDLHGLNSDSDDGGASDESEDERVFKGRGKAKAKAKKTAADDDTNDSEDEATNHPDEDDNYLDATPAAPPKQSTRANRPRRTKQPFALKALLEKRSFGPITRVFLSPEVRSASAPRKRLNKRKTYSDGWVEFASKKTAKVCAETLNANIIGGRKGGWYHDDVWNMKYLRGFKWADLTEQIQRERSEREARQRVEDSKARKEDKVFLEGYERGKVIEGIQKKNAEKGKKSGKEEQKVRMVFKQSEVKQGRDKIADPGQMGDETKRVLGKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMU0</accession>
    <name>A0A317WMU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitochondrial fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_493005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466968.1">
        <property type="nucleotide sequence ID" value="XM_025609192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMU0"/>
    <dbReference type="STRING" id="1450535.A0A317WMU0"/>
    <dbReference type="GeneID" id="37111335"/>
    <dbReference type="OrthoDB" id="77989at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY86377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="505" mass="54520" checksum="0A6DF7C0B2F5A992" modified="2018-10-10" version="1">MMTAPLDGPNPLRPYYIPPSLGLDAANASSPPDASSATQVFGGSARDLLPDLDYSEYLDNSPSLSSWIRDALDQAIWRYTGVLTAQPFDVAKTILQAYVVPDYVAEEQWARHDRRSSGVSSQGEGESGDEEESLSSDDESNYFTSAAPAVPPPCNSRSRKPQRHITDRSGYIPSSTASSRYALSIKNPSSLMEVLSQLWTTSGPTSPWKATNATFIYSLLLPTLNTFIRSLLSAIVGLPEEDVTSSMTADILTSTSPVATLILSFISSSLSAMLLSPIDTARTFLILTPATHGPRSLLRALRQIPTPNCTIPSHLIPITILHSSLPNFITNTTPLVLKTYLSIDPVLNPSAWGLFTFLGSGLELAVRFPLETVLRRAQIATFTSPSIRQQSSGSVRSASSSTTAQTKVPAVETIVPTPQTYRGIIGTMWGVVYEEGLAVAPEVERARELLNKQVVPRKRQGQGLKGLYRGWRVGMWGIAGIWGASLMGSASFTGDEDSMTSGGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN55</accession>
    <name>A0A317WN55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Kynureninase</fullName>
            <ecNumber evidence="5 6">3.7.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biosynthesis of nicotinic acid protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-kynurenine hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">BNA5</name>
        <name evidence="7" type="ORF">BO94DRAFT_535268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25143"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:58125"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>L-kynurenine + H2O = anthranilate + L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16813"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="3.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 6">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the kynureninase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.3" evidence="5 6"/>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN55"/>
    <dbReference type="STRING" id="1450535.A0A317WN55"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00329"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00334">
        <property type="reaction ID" value="UER00455"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030429">
        <property type="term" value="F:kynureninase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097053">
        <property type="term" value="P:L-kynurenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000031">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01970">
        <property type="entry name" value="Kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010111">
        <property type="entry name" value="Kynureninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01814">
        <property type="entry name" value="kynureninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084">
        <property type="entry name" value="KYNURENINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14084:SF2">
        <property type="entry name" value="KYNURENINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22580">
        <property type="entry name" value="KYNU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038800">
        <property type="entry name" value="KYNU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="162"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY87171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="463" mass="51362" checksum="CED05138EE8977DC" modified="2018-10-10" version="1">MSKSNSTNLAFPAEAATKEYAASLDSSDSLATFRDKFIVPSKANIVSKKLAKPGLSSEPCIYFCGNSLGIQPKPTARYLEAQLDTWSSIGVGGHFTDLEDSPLKQWQLLSEQAAESMSKIVGAKAEEVAAMGTLTTNLHLLLASFYKPTETKHKILMDWKAFPSDHYAIESHIAWHDLDPKESMVLISPDEGEYEISTQKIFSYIDKHSDDAALILLPGIQYYTGQLFDIQRITKYAHSRNMVVGWDLAHAFANAELKLHDWNVDFAAWCTYKYGNAGPGAMGGLFVHEKHGEVDYSAGEDEPKFRHRLTGWYGGDRSVRFKMDNKFKPIPGAGGFQISNPSAIDLACLCAALSVFDETSMADLRRKSVSLTAYLEFLLLKDTEEESRPFRIITPAHPEARGAQLSLLLKPGLLQNVAHRLQEAGIVCDKREPGVVRVAPVPLYNTFSEVWTFAKIFKDALAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQ80</accession>
    <name>A0A317WQ80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NACHT and TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_534468</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467941.1">
        <property type="nucleotide sequence ID" value="XM_025611559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQ80"/>
    <dbReference type="GeneID" id="37113702"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="103"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="696"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="778"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY88579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1170" mass="132010" checksum="5F5DAAE075D801A5" modified="2018-10-10" version="1">MTVTSTNTTVMETGMTVNQMSYQVNEVQEMLSTLVISANESKQESLEDREQSLQTLVNKILRPSKTDSAQDWYDKINKARIPGTGDWIRSEDIFQGWLSRDTPVIFVSGNPGAGKSYLSTNIISMLREQYPQGIQSTSLVSVGYFFFKDDNPDTRSIHLALRDLAFQISKSDPVYRKHIVAVEQYDKINSLESAWRLLFVDYFLKKPGADSSVYILLDGVDEASDEERGIFLSLAKDLYNAPEKARLQLAVVGRPHISDQLLEGLETEVPTIHVTTQKNSDDINQYIHASIKKSVVLRRVSTKLRHEIVEKLSAGAEGMFLWVNLMLQELVKKRNESSIRKALDDPPKGLKEILRHVLANFSISSNEEELEYLNEILLWVTCSQQPLTLGLIDAILKLKSPEGDGIIYLEGALRRQFASFFTLDREDALTTAELQNMSTKPDVFDGSDDEENEDQDEVFEDVDNFTDFNSDLQTTTVTFCHASIGDFFRDETESKVSAGEGHLAVGVNYHEAKAHVLKTFLRLFTDSEFADKADDSKKLFIHAAQAWVPHLLTTSPSECSFEDRTETAKLLLVVFRSEEVISGWIGCRSWVSTNASIQAVRQWWKDDAVLTFLSDDEREFIASTEEDPMKTFEPVVMFCVKQWLCKKMWSVSPLAAVVWSYQSLCKGKEVNFLENYNPTAADLIEAAEFGDLEKTALSYRRCAIALREVGHYETALEYFMKSLELDSDDWLTKSGMAITYTLQKQYQKAIELDQEAAKRISEEIEADPENDDLRLGLHTILERMGDSYKQLGDLEKRFKSFSKAYEYKPYCNTCINALLEHHHSHQDHQATIDLLTQLADTSVPDEDYSQLTQTVWLNADCECHFFSFALDAALATGTLSLMIESWRLAAKAARRALKTVTAANIELGLARIYSEFMHDQEKAVKRWENIINTYASSKDETEIGIIKLQASYRLAQHYLSEAVNAGVGTSEAEEVAAKLEKLSMQAKGDGNPLTFALQTAAALSLGVYHRLKRQETEARALIRPSIKQGIHILSDDDPENDTMGLMNLLTALLAANDTKNIIAVAYALGAYEEEPDELEMWTCDGPCHRDWPNADEFSLCTICFDTFCKDCVKMVAEGTMAINRCNSSHAQSFVYVPPRPKGTAQGSMLVDGEEMDFEAWKNLLRKEWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQD7</accession>
    <name>A0A317WQD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_534504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467978.1">
        <property type="nucleotide sequence ID" value="XM_025611568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQD7"/>
    <dbReference type="STRING" id="1450535.A0A317WQD7"/>
    <dbReference type="GeneID" id="37113711"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="32"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="129"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY88616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="329" mass="36620" checksum="AFBC855A5846DA05" modified="2018-10-10" version="1">MDPSDVTIPPMKDLTVDNITENVIQINSLCKDERMKYVLERLVTHLHDFARETRLSTDEWMTGLRFLTEVGKICSDVRQEFILLSDILGLSILVDSIDHPKPPHSTEGTVLGPFHTHDAAPLAPGASISHDPAGEPLLVVCTIHDTHGNPIPNVKIDIWETDSTGHYDVQYPGREGPDGRCVMTSDKEGVFWFRAITPVPYPIPHDGPVGKLLKKLGRHPYRPSHMHFMFEGVGFDHLITALYLRSDPYETSDAVFGVKDSLVVDIGRAGPEYAAKYGVAEDHALLTYDFVLVSDEETSELRARNSKEALDKLGRKVRIVNGLPVPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQE7</accession>
    <name>A0A317WQE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_585715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467356.1">
        <property type="nucleotide sequence ID" value="XM_025615711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQE7"/>
    <dbReference type="GeneID" id="37117854"/>
    <dbReference type="OrthoDB" id="2565191at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022793">
        <property type="entry name" value="Rrn10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="244" mass="27448" checksum="3246DBB05AF211AB" modified="2018-10-10" version="1">MSYGKSLALSQNSFVQPPLPDVPEAPDQQDELAARRQRRQATVYDAVAGRVNYHGFLPLAPYPSKYRATASSSTRPVRPEEVLFRRQNAPTRYEENDFYFAHESLPPSRPLPSSDLLEAIHAYSADYYDHATIDRGRDDYQSMDETALIAMGILMEEMAKESLGETGDMVLVEGEEAVSDEDPLVPRVSRKMGRKRANTGQSSTMASSGDDLESVVKKRRPKKRKLGRRMTSATDIDTEADERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQJ7</accession>
    <name>A0A317WQJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_515570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468055.1">
        <property type="nucleotide sequence ID" value="XM_025609926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQJ7"/>
    <dbReference type="STRING" id="1450535.A0A317WQJ7"/>
    <dbReference type="GeneID" id="37112069"/>
    <dbReference type="OrthoDB" id="20821at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="248"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="517" mass="55201" checksum="8DC7F6DBE374D89E" modified="2018-10-10" version="1">MASTIHDPRLLYSINNIRAYHLQNGEETELTPSGPQTLSLLMVPTRTSTPENSFSTPPPNTSAEDDFYLHLHLPPELDLALPATTQIFHQHPDSYLIPRWDLGPNAGVFIRIQFPGVGSGPGRVTQDDVDTFETILAQCTAFLERAPPPSDHAPYNPAAYAPNEGYISSPGTSQDDSHGRIVLVDEEDGSVVGEMEGYDVVEKPGVQPGSKRPVEVELPNEGEGNQVRVSNVSEEYLRMARHPAYKDSTIVQTSATASRLIVTGSSYLANILTSGAESFTKKTKPNPKPMTFSETTHSRIRRVGTFSQGAADLSAKTVGQVGKYAQNIGASLARRKENDRQRGTERYGNDYKPGILNKSMIAFSTLTDGIEQSARNVLISGSTAASTMIGHRYGEQAGSVASNLTGGVKNVGLVYIDAAGVSRKAMLKSVARGMVVGRMRNGQQVLIGTGDGGDVPPGAAGPSQQPQQSQQPQQPQQPWSGLPPVMRRPSSSATPPPAYGAPGTTSLGGISMSGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQL9</accession>
    <name>A0A317WQL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_595628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467774.1">
        <property type="nucleotide sequence ID" value="XM_025616230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQL9"/>
    <dbReference type="STRING" id="1450535.A0A317WQL9"/>
    <dbReference type="GeneID" id="37118373"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="26"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="655"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="709"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY87991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="761" mass="82889" checksum="43AE9F223CD4DD97" modified="2018-10-10" version="1">MMFGSSVDNRRKVEAVDKGAFAVPKKGETFELRAGLVSQYAYERKESIQKTIMAMTLGKDVSALFPDVLKNIATSDLEQKKLVYLYLMNYAKSHPDLCILAVNTFVQDSEDPNPLIRALAIRTMGCIRVDKMVDYMEEPLRKTLRDESPYVRKTAAICVAKLFDLNPAMCLENGFLEMLQEMIGDPNPMVVANSVTALSEIYHAAPETQALKVTSNTLRKLLMALNECTEWGRVTILTTLAEYKTSEVTESEHICERVSPQFQHANPSVVLAAVKVVFLHMRNVNAELASNYLKKMAPPLVTLVSSAPEVQYVALRNIDLLLQKQPDILNKELRVFFCKYNDPPYVKFQKLEIMVRIANDRNVDQLLAELKEYALEVDMDFVRRAVKAIGQVAIKIESASERCVNTLLDLINTKVNYVVQEAIVVIKDIFRKYPGYEGIIPTLCQCIDELDEPNARAALIWIVGQYAEKISNAGDILAGFVEGFNEEFSQTQLQILTAVVKLFLKRPEKAQGLVQKVLQAATAENDNPDVRDRAYVYWRLLSNTSDPNATKTIVLSDKPPIVTTIQSLPPALLEQLLGELSTLASVYHKPPEQFVGQGRFGADAVQRAAIEEQIQNARENPLAAAAAAAAVTGSAPPPQAQNNMENLLDIDFDGTAPASAQKEPSGGMSGLEGLAGTPVRVESPAVGAPAGSNNLDDLLGVFGDGGATASASGSGAPNGGGAGTDLMNGFDGLDLSGGSMASPPPGGSQPKKTNEDIMSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQW2</accession>
    <name>A0A317WQW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Galactose-binding like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_623864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468158.1">
        <property type="nucleotide sequence ID" value="XM_025617178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQW2"/>
    <dbReference type="STRING" id="1450535.A0A317WQW2"/>
    <dbReference type="GeneID" id="37119321"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="191"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="474" mass="52848" checksum="83BDD2305DD0A716" modified="2018-10-10" version="1">MPRHHHLLRRNPAPDTTSPSDTATTHRHPPQPPPAPNAPAARASATTRNGKLPRRKASPFHNCIRPRVPLIQTTPFTATQANMQPTTLPQPPRCHQMMDEDDEEDIVEEEYDEGPSEHVHEQDHDQLNRLRQRHHHRRLHTRSVSSDELLSTQDIHDRDEPSVIEEIDPELGHQHEEEEEIEEEEEIDPEPGTDSEMLHDREKSPTPLPPNLREISSLASWTVSTHKPGCGVLALRHPSPTQYWQSDGPQPHTLTLHFFKLVAIVRIRVYLDFEMDESYTPTKMTFLAGMGGNDLVEFANWEGEGPCGWVDVELEGVGGRSGGWVRSTKSGGGGGGTGGRSAGAGIGGMIKGKGKRGYVFKDHGGGSDEDEDEDEENDPYAGNVLKAMVIQMRVIENHQNGKDTHVRGFQVFARDDERKRVGNAPSASADGRVRRHSVRRSLRGSTQEMEGPEAHAKVVTSLEEPDWMGEPVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSD5</accession>
    <name>A0A317WSD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_574365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468294.1">
        <property type="nucleotide sequence ID" value="XM_025615017.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WSD5"/>
    <dbReference type="GeneID" id="37117160"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001205">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001861">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002324">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="11">
        <location>
            <begin position="4663"/>
            <end position="4867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="4032"/>
            <end position="4516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4109"/>
            <end position="4134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4138"/>
            <end position="4158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4173"/>
            <end position="4187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4188"/>
            <end position="4210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4211"/>
            <end position="4227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4228"/>
            <end position="4269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4276"/>
            <end position="4326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="4366"/>
            <end position="4377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4418"/>
            <end position="4441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="4442"/>
            <end position="4457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="4489"/>
            <end position="4499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY89383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="4879" mass="543606" checksum="80BBA12918968AA4" modified="2018-10-10" version="1">[encoded data, 4879 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTE4</accession>
    <name>A0A317WTE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex protein EXO70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_490174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Bud</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Bud neck</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the EXO70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468276.1">
        <property type="nucleotide sequence ID" value="XM_025609113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTE4"/>
    <dbReference type="STRING" id="1450535.A0A317WTE4"/>
    <dbReference type="GeneID" id="37111256"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF41">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="246"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY89365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="631" mass="68775" checksum="C31AAF0EB04A4DD0" modified="2018-10-10" version="1">MVAPRNAAYAEESAEVEVLYANLEKLKLLTKKIQGSLNRLETGGNVVKHAIGPIYSNTQSLQITNSNIDKVNEAIERLRQPLDAKGKEEGIIRSSPQSVGLPQYLSAVKRVEKALADLNSTNLKSNQKAISEFTSLLVLGNSQLQDMLRSTLGDHVSPIEPLHYLTKELSFPSLPEETVAELGPVCAAIGSAANYGPQRGDGGNPALKIYADIRGPYITSSLQNLAIASLNTVKRRAADGPYKQGTNGIGIYSNALESFIYAEHEVLVHIFTGDQRGLALQATCRSALAEYSQTLRELNQYIKANLMTDCFLAFEIIEIVTAMSYRVESKTGELKSLFIEALRPVRETAKSSLAELLEETKRKAAGIAMLPPDGGSVPLVSEVMSSLTTLTGYSGPLASILTSLGDGNWRSTTNAAPTAPLDVSPDSLTLLSHFILDMIEALMIALEARGRALHRSKAVQGVFLSNVFCTVDRSIRQSSELARYLGSADSIARIDTFRKRATSTYLDAWKETSHYLLDVQYTSRGSGGSARPASGGVVDSSAIVKSLSSKDKDAIKDKFKAFNASFDDLLNRHKALYMEREVRGVLAREVQAVLEPLYARFWDRYHEIDKGRGKYVKYDKGSLSAQLAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WU28</accession>
    <name>A0A317WU28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_534380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468506.1">
        <property type="nucleotide sequence ID" value="XM_025611533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WU28"/>
    <dbReference type="STRING" id="1450535.A0A317WU28"/>
    <dbReference type="GeneID" id="37113676"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="2">
        <location>
            <begin position="123"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="462" mass="52726" checksum="1C3ACEA7B2BEB143" modified="2018-10-10" version="1">MSHHQSIYQTTTSSPDHNPNPKPTTVRRSLQSTSILARNHYLQNANRHRHRRNRYASHPQPTNHSNHSLPIGILGREIIAHLSKDPSYQTIHALSRSKKSTYPPHVHHASIDLLASPESLASQLSSQDVSGDYLFFTAYLQEGDEKDLERINGDMLENFLKALSISGAEKKVKRVVLVTGAKHYGVHLGPVKNPMEETDPWVEGEGRPPNFYYRQQRILKGMSEGKGWDWVVTYPNDVIGVAKGNFMNLVTAIGLYAAITKELDAPFIFPGSRIFYPKTDCFTYSRHHARFCAWAATEPACSNQAFNVVNGDTQTWQTMWPCLAERFGVTIPADQFQAEDEKVVPLIERPPLEDYAETSGLKGKVEKGEVRMRIDLEKWTEREDVKAAWERLAQREGLEKDAFEKATWFFLNFVLGRNYDLVISMNKAWKLGFRDWADTWDALEECLDELEDEKVLPRTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUA6</accession>
    <name>A0A317WUA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_43490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468576.1">
        <property type="nucleotide sequence ID" value="XM_025607489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUA6"/>
    <dbReference type="GeneID" id="37109632"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="168" mass="18930" checksum="0B5D200D876E6C2C" modified="2018-10-10" version="1">MLAETEARKHDQPDSMAATNRKPPKKTGSSEHLDSLRMSTVVVILFDCIRQRDTHWRDSPPSRSLNMAFSHPACPAYLYRSPTISSTCMAYPCQQLSLNVEQAHEVSFLPFSRFSTLFLNWHVSSFLAYSVDSCQFLSKHKPYIFGTCLSLNHEVLPSLGPGGFIFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUT3</accession>
    <name>A0A317WUT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_584818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468482.1">
        <property type="nucleotide sequence ID" value="XM_025615656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUT3"/>
    <dbReference type="STRING" id="1450535.A0A317WUT3"/>
    <dbReference type="GeneID" id="37117799"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="279"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="386" mass="42511" checksum="F8DF8E146184324C" modified="2018-10-10" version="1">MSLRRSLRSRPGRDDQPSMEANTSTRPTRLTRAATSSPAVTVVRVASDLSGDSKKSIRLTVKMPSSKLREVTGGSTRSGASTRRSVNVFTENPIVTGPRTSRPKKKLVEVDTSDEDDLEDQEEDEVDDEDAPGEDDDDVDADGDLDMDDVPPQPPVSKRQAKAAAAAAPAGRAVKSVEAKEMELDNDDEDDDDDDEELSELDSDAEGEPDDQDESILANGGAEDLDEEEEEEEEELDSDDDTPTADLSRMTKRQRGTLGNDFLQLPMEPQVKKHLTAEERAMRRAEMARRRKNLSEKRNEEEKLDTINRLLRKQAPKRRGRIPAAEAAEAASAEQEIQEYEKADPTMVRWVSGRNGSRVGVPEEWLGIPAGRVFGGNGSGKLVQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVM2</accession>
    <name>A0A317WVM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_595277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468260.1">
        <property type="nucleotide sequence ID" value="XM_025616221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVM2"/>
    <dbReference type="GeneID" id="37118364"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016270148" evidence="1">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="300" mass="33672" checksum="AF0F0A7FE1F2A294" modified="2018-10-10" version="1">MRISWVLITAALSWAPTAWGFNHPTSTSYTFDELWDLETKFWDNFLYPANVQQMLAINSTLFTADVQGRVDITRVFNGSELNTEYLFGLFSDPDHVSLVGVPIAYSITQFSGNGNIASATTVVTFNATSFNNLLIPVTIDTWIMWDSNGQIEQYDATFRWFGFLLDTLVNALATSINGTIAEATASLTQLLATTICATHDQYCTGDNQQYTNSSTCYDFLTQDIPLGKDYELGRNTLLCREVHEHMVQYDPALHCPHIGPTGGDYCVDDQTYAEKVLQKYFRKSWIAGGAGEYDDQDIWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WXU7</accession>
    <name>A0A317WXU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_534397</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468529.1">
        <property type="nucleotide sequence ID" value="XM_025611538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WXU7"/>
    <dbReference type="STRING" id="1450535.A0A317WXU7"/>
    <dbReference type="GeneID" id="37113681"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000065">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="394"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="157"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="487"/>
            <end position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY89618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="743" mass="83007" checksum="DA87A4C5D60C3649" modified="2018-10-10" version="1">MTSKSTTLSQPSRPRTTTQAPEVGRAGAGAASSRINSNTTRFHGRANSHSSTSLTRSASTSARTKAATAGPPRPHTSMSRTHSVASSRKPNGHAIPRPATSLDTHDEEDSATSVLGKRKGAEWDQESRERTMEDLLNTFVTRIGQAGQESNGLKEALDLYKSRVSELEASRKEITDTNLTLRVEMESLKVRLGAAEDALKDAQRDHDMEVDNLSAHQRIEVESARSEGRKELEALKSRHQEQIQELKRRYEHEIEDERAARLREISQLTSQTAIDTQRSNMELDRREREITTLRDDVQALRAELERERKSNRNLRQNLDTASTNGVTLESSIRALKARIEFLESGREEQSQSFERLNQKMMDALAETNTTKDKLRKEETLRRKLHNQVQELKGNIRVFCRVRPSLPSDPTTGVAQIQYPDETEDSKEIALLGPEEKSSLGTISRKNSNFSFDRVFGPTTQNAEVFDEISQLVQSALDGYNVCIFCYGQTGSGKTYTMSSLDGMIPRAVHQIYETAKGLEEKGWRYTMEGNFVEVYNENLNDLLGNPEELDKKKLEIRHDMQKGKTIITDVTTVRLESPQMVETILRRAASNRSVAATKANERSSRSHSVFILKLIGENDITGERSEGTLNLVDLAGSERLSHSGATGERLKETQNINRSLSCLGDVIAALGQGKDGGHIPYRNSKLTYLLQFSLGGNSKTLMFVMVSPLQAHLSETLTSLKFATKVHNTHIGTAKRQARVRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WXZ3</accession>
    <name>A0A317WXZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_583926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469034.1">
        <property type="nucleotide sequence ID" value="XM_025615593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WXZ3"/>
    <dbReference type="STRING" id="1450535.A0A317WXZ3"/>
    <dbReference type="GeneID" id="37117736"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="253" mass="29025" checksum="1EBB402532B30344" modified="2018-10-10" version="1">MSNTIYITHTTTTSDTLSTILSTLLHDLTQVTEPTEITYSCIPPTMGSHLADALSENEIAESLNTKITYNSLTTTLHLRIFRPPLLAIQHSWINEQTFDWMDEQIMTRMEFKQLAFESNICFSAPYEFSRGTSDLQLRPRDKPLPSFVIESTWAETYERVRENEGNDEVEGVVEVWVRDEVNVWETVVRQREVIFPADEAVADRLKVTWGEVFGGHLPDGRDKGEYLYLELESLQFQARNALERMGLRAAGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYR9</accession>
    <name>A0A317WYR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WH1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_545226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468860.1">
        <property type="nucleotide sequence ID" value="XM_025613224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYR9"/>
    <dbReference type="STRING" id="1450535.A0A317WYR9"/>
    <dbReference type="GeneID" id="37115367"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="164"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="245"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="459"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY90482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="652" mass="67952" checksum="75C6ED24112298FB" modified="2018-10-10" version="1">MPSILNDNDKETVRRAVPKPDNKIFAVAVARLYVAHPDTQRWTYTGLQGAAVLANDLVGRTFWLKLVDVSPANRGVIWDQEIYENFAYNQDRTFFHSFELEDCPAGLSFADEKEAKTFIKKVVEREKHASKETRQTPFASTRGQGPAPVVNGKSGVGRSLFGSLLGHRSSSASHGPPPVTPAELPPAPSIQVAPPPPPASSPPRKELPFDTNDPAFKGILDELLQMGITEDLIAENFDFIKSYIEQKQSTAPTPPPADDQRRGKAPPPPPPSAPPGPKVANISPQNTGNSTGSRRGAPPPPPPTRRTRIDAAEEEPASKREPSPPRNRFRAPPPIADAGKFAHAPGPLPPTRQRALSSATPGPPPPPRPPKTPMDEPQSRFGVPPPFQGERKVSAPPAPPNRPVPSGPPLPPPRTMSPAPPPQLPPKVPNKSFATSAPTRTCRLPAYPSSAYVERAASPTPPPTANVPPPPRPPPSSSVPPPPPPPPSYPSPSAGPPAPPPPPPPAPTSSVPPPPPPPPPTSTGPPAPPPPPPPIASVPPPPPPPGVGAPPPPPPGGAAPPLPQAEGGRGDLLAAIRASGGKGGGGLRKVRDSDKRDRSAALVPGSASESSAPTPSGGAPQGGLAGALQDALAKRKQKVSGSDDEKEDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ34</accession>
    <name>A0A317WZ34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_489523</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469367.1">
        <property type="nucleotide sequence ID" value="XM_025609091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ34"/>
    <dbReference type="STRING" id="1450535.A0A317WZ34"/>
    <dbReference type="GeneID" id="37111234"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF4">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="78"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY91639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="530" mass="58492" checksum="2A6FE3BAEFBBA921" modified="2018-10-10" version="1">MASLLPSMGIAIALLMGVWLMRKFSNSPPQVIATIPPSVPHPLSQKLEAALPQRVLLLHRDGEQFRQSINTYFSGQARDVVQAAIVRPRTADEVATAVHIIKEEYDQQSTPRHDTENVLFAVRGGGQAPVASSATARGGVLIDLTHLREVTVAEDRQSVTIGAGCVWVDVLRVLDSMNLGVVGGRSAPLGVAGFTLGGGISFYTPRYGLACSNVLAYEVVLASGEIITATATSHPDLWTALKGGSNNFGIITRFTMHCFPSTPIWTGSVFAPGFEITKALNAFHDSVQRQADTEVDLFAAPPITCYTYIQAVRLRVITIQLAYTKPPEQPNKWPLFWQQSGFLRLWRFRSTHSVRTTTSAMEENMNRDIVGQRNSFGTTTIHNDLPTILAAREIFDEAMGSMRKMKGVFFTMFMQPLLPSWVGKGDPNILGIRESTEKPLIIVTMSFTWASAQNDSYVESVTRQIIEKIDAVANANGTGHPYRYLNYCEKWQRPLEGYGETNLQFLRKVGKEYDPDGLFQWGCVGGCKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ35</accession>
    <name>A0A317WZ35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_489481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469341.1">
        <property type="nucleotide sequence ID" value="XM_025609089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ35"/>
    <dbReference type="STRING" id="1450535.A0A317WZ35"/>
    <dbReference type="GeneID" id="37111232"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF14">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="35455" checksum="9E04C49B4C31C0A7" modified="2018-10-10" version="1">MKSALSPAYKPLGTRDRDVLDGIPESEDDVPKESSQPQSCHTRHKLFLWLNATLFTLSLFLFTITASLLRTDTNQLLRQTSEYSPMFDQLPIPLLTKQMNATLVEPNPLPIYRQPPSPSVDAAWNRLANINPIAITRNDVIKLGRDPAQAAKWPESFGFGPDAYIGRLDIFHQIHCLDWLRRETYFDHYYGKKWPPGTPPSDMHRTHISHCIYILLQNLMCNANVDIYTHFWADAQLNAFPDFSVNHKCRDFEAILAWQEENSVDVERFAAIRRPEGVVARVMSRRFKELFGWYKSHEVGGGDELGEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ68</accession>
    <name>A0A317WZ68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nitrogen regulatory protein areA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_463440</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Major nitrogen regulatory protein. Positively acting regulatory gene of nitrogen metabolite repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468935.1">
        <property type="nucleotide sequence ID" value="XM_025608024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ68"/>
    <dbReference type="STRING" id="1450535.A0A317WZ68"/>
    <dbReference type="GeneID" id="37110167"/>
    <dbReference type="OrthoDB" id="515401at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000007">
        <property type="entry name" value="Nitrogen regulatory AreA, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011420">
        <property type="entry name" value="AreA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039355">
        <property type="entry name" value="Transcription_factor_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071:SF281">
        <property type="entry name" value="BOX A-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10071">
        <property type="entry name" value="TRANSCRIPTION FACTOR GATA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07573">
        <property type="entry name" value="AreA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00619">
        <property type="entry name" value="GATAZNFINGER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="15">
        <location>
            <begin position="659"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="136"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="450"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="573"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="712"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="606"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="715"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="736"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="749"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="772"/>
            <end position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY90557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="870" mass="93062" checksum="0EC436A0F4C2E1DF" modified="2018-10-10" version="1">MSGLTLGGGVRPTQSAAFASLQDSADADRRSSTTTTNPLHFPPTSSQLSDDFSFGSPISPADSSNAQDNLLQDTLFPEWKAGPPRGPFDGTDEMQRKDPLATQIWKLYSRTKAQLPNQERMENLTWRMMAMSLKRKERERAQQSRLSARNSLSGPSGIAQLRLSDREPTVATTSTITDLTSDPMNLDDFIVPFESPSDHPSPQATKGEATSAAIPIKSRKDQVAESTPVPASFPHPPQDQRKNSEFGYVPRRVRKTSIDDRQFFNLQVPTRKRPAESSPQVPPVSNAMLAHDPDLSGGVPDYTLDASSAFALHHNTHSSSHQNHTSPGVPFGLDTYGLSDDPILTSAGPYQTQFTFSPTESPMTSGNPFANLYAHTPVASSLNSTDFFSPPPSGYQSTASTPQPAYDGEHSMFFDMPSVDARTQRRVPNYVSHRTSNLSASLQPRYMFNQSQDQSHHAGNHSSSMHSPGYPIPQPQHVDPSQVLGPSDFSTGASHAAMFSFGADSDNEDDEGNQFSDRAGLPMSGELDDGADMNGGMQWDAQFPGSFHSLPGFSAQHRKHVTIGSADMMDTPSEWQGTSLGRTHGSAASVSEVRNREQDPRRQKIARTTSTPNTAQLLRQSMNANTSHTSPNTPPESGLNSAVPSRPASPGGSKNGEQSSGPTTCTNCFTQTTPLWRRNPEGQPLCNACGLFLKLHGVVRPLSLKTDVIKKRNRSSANSLAVGTSRTSKKSARKNSVQQSTVTTPTSSRAQSGATSSESPPAVPGGSSSNRAAGVIPIAAAPPKANPAASSPGQSRGSSVQMAPKRQRRLEKATDAEAADDASKSTTSSGRSKVVPLAPAMPPAAANPANHSIAGGQGASQEWEWLTMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZI6</accession>
    <name>A0A317WZI6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_461492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469524.1">
        <property type="nucleotide sequence ID" value="XM_025607930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZI6"/>
    <dbReference type="STRING" id="1450535.A0A317WZI6"/>
    <dbReference type="GeneID" id="37110073"/>
    <dbReference type="OrthoDB" id="4185642at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26764" checksum="3FC7DE714C16A848" modified="2018-10-10" version="1">MPDTIQVSPSDIQVLQTLRRSEHSTVLKVAVRGETRLMKIYRDRLPSEHDSPDREINPFTCESSAYHRLKEKGLCTTGVIPYFYGIITNIQPDLWPELYIRSDDGRPLNAVVLEYIDNMHQMDLSTFSESRLTQLERILHEIHEAGVLHGDPDPRNMMVCAGRNGRQDRVLWIDFDLAQLPPGGYLSLRQQMWLQEENDLMDYFVKSLPEDYREGRLNRTWNYYYTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X020</accession>
    <name>A0A317X020_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_489278</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469239.1">
        <property type="nucleotide sequence ID" value="XM_025609086.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X020"/>
    <dbReference type="GeneID" id="37111229"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000073">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF7">
        <property type="entry name" value="ALPHA-1,3-GLUCAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="947"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1870"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1904"/>
            <end position="1921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1928"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1966"/>
            <end position="1983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1995"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="domain" description="Mok11-13/Ags1-like GH beta-sandwich" evidence="10">
        <location>
            <begin position="456"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Mok11-13/Ags1-like Ig-like beta-sandwich" evidence="11">
        <location>
            <begin position="593"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Mok11-13/Ags1-like second Ig-like beta-sandwich" evidence="12">
        <location>
            <begin position="721"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Mok11-13/Ags1-like CBM" evidence="13">
        <location>
            <begin position="825"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Starch synthase catalytic" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall alpha-1,3-glucan synthase Mok11-14/Ags1-like transmembrane" evidence="14">
        <location>
            <begin position="1861"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1521"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1670"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1822"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1525"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1578"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1620"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1635"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1698"/>
            <end position="1709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF26108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF26122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF26127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY91511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2041" mass="228651" checksum="A449AE963B44D554" modified="2018-10-10" version="1">MNQPWGFDGYSALDTTLLDQHYGDLQTWRDAITEIHKRGMYVILDNTIATMGDLIGFEGYLNTTTPFSVKEHKVEWKTDRHYVDFEIGNTYNDTCDYPTFWFENGYPVQASVTEELVGCYDSDFDQYGDIEAFGVFPDWQRQLAKFASVQDRLREWNPSVRERLIRHSCIIIQSLDIDGFRYDKATQATVDALGDMSSAYRECARAVGKENFFIAGEITGGNTFGSIYLGRGRQPNQYPDTAEAAMKLTNTSDAQYFLREAGHEAIDGAAFHYSIYRALTRFLGMDGNLAAGYDVPVDWVDAWNLMLQSNDLVNANTGKFDPRHMYGATNQDVFRWPTVEKGVERQLLGQYITTLLLPGVPLLLWGEEQAFYVLDATAANYIYGRQAMSPATAWRDHGCFSLESSQYYNWPIDAGRNGCHDPTVAYDHRDPSHPVRNIIKHMYQMREQFPVLNDGYSIQKLSNMTEDVYYTGSNGTATETGLWSILRDVNADVQDLGSDAKNQPVWLVYHNTNRTIDYKFDCSDNDTALISAFPTGTWVKNLFHPYDEHQLIDSPVKLGLNGSTEYNGCLANMTMEAYEFRAYVPKTRFAKAGPMLTKFTPGHDYPLRSTVAPNADEDVNIELYFSEEMECESVTKSITINSSTEIGKAPSLDSNTVSCKTISATNTTYTGQIPSVWMWTANLTGVYNGVHRITVSNVSTASGNASTNAVDHLLFRIGQIDNPMIFTSANYSTSLLHEEPNGTLFIQHHAAGADKYRYSTNWGTTFSNWMPYQGGNDTIEVLPWSGTKKQEWKGNHVRVEYWNRWTGSSDYVQEGDSNWNGKVPRRFPHVFFNGPFNQYGYDAGLDNVVRQDSVDGIWKYHFTAEWPAQAQLNIWGMNPNGKPDQSWVLGDADNDSVLDRMPPSSLSATLINITEHPPSPYISWNVFIDDGTMRFQLFPVGHQNTQIAMFVLFWIVPVVTGCLGVWVFMKSFYKVKFNQVGVSEKHQMIPLALRRKFKRSRKGDEENSNPLMRLANKSGFLQATTAIGGAASGKRRMVLIATMEYDIEDWAIKIKIGGLGVMAQLMGKTLGHQDLIWVVPCVGGIDYPVDKPAEPMNVTILGNSYEVQVQYHILGNITYVLLDAPVFRQQSKSEPYPARMDDLNSAIYYSAWNQCIAEACKRFPIDLYHINDYHGSLAPLYLLPDTVPACLSLHNAEFQGLWPMRTQKEKEEVCSVFNLDIEHVRHYVQFGEVFNLLHAGASYLRVHQQGFGAVGVSKKYGKRSYARYPIFWGLRKVGNLPNPDPSDVGEWSKEQAAAMSNDVNVDQDYEAGRGELKRQAQEWAGLEQNPDADLLVFVGRWSMQKGVDLIADVMPAVLESRPNVQVICVGPVIDLYGKFAALKLDHMMKVYPGRVFSRPEFTALPPYIFSGAEFALIPSRDEPFGLVAVEFGRKGALGIGARVGGLGQMPGWWYNVESTATSHLLVQFKLAIDAALSSKTETRAMMRARSAKQRFPVAQWVEDLEILQTTAIQVHNKELVKSHGRPFTPSGTTTPGGIMSQPASPLMPPGIQTPMAHSRDSSYSNLNRLSEYVADPKTNYSRDVSPSGTEKPKSGLHRQLSLGVRSGPGHQDRRGRRGRQRDSIPEHEDAAVMTDVEEDRDDDIPEHPDDEYTLTAAQVEEGRRLQAVQQNELGMPTSPPGANRYSQDSMHPRFNQPPVSPGPVPTPSQSLLPPPRLLEAGNRLSSASVLSLDSVVGTKTDFKLQKVDPFFTDSTGEYYKAFDKRLVGLNGANSESQLCIEEYLIKSEKEWFDKFRDARLGRLKSPASSIFRDKHGASPVGSYYDDAGSHVSGDDNSESRDTEDDEFLLGKDYVPPTGLKKWMQLRVGDWPVYSLFLALGQIIAANSYQITLLTGEVGETAEKLYGIATTYLITSILWWLVFRYCKSVVCLSAPWFLYAIAFILIGSAHWDSNSFNRGWIQNVGSGFYAAASSSGSIFFALNFGDEGGAPVETWIFRACLIQGIQSAYIIALWYWGSTLTKASSEGLLTSTNNIANSWKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0B9</accession>
    <name>A0A317X0B9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_544439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469443.1">
        <property type="nucleotide sequence ID" value="XM_025613177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0B9"/>
    <dbReference type="STRING" id="1450535.A0A317X0B9"/>
    <dbReference type="GeneID" id="37115320"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
        <property type="entry name" value="APPBP1_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000451">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000721">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="6">
        <location>
            <begin position="19"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY91715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="558" mass="62132" checksum="DAD5B6EF2BB81B15" modified="2018-10-10" version="1">MTETFPSALVGPSSKERKYDRQLRLWAASGQKALEESQVLLVNSDGPWSKQNTGVSGVVGVETLKNLVLPGIGGFTIVDPALVTEPDLGVNFFLEEKSLGKSRAEETCRLLRELNPDVDGSFYTKPIAELLRDPEFLTQYKLVLISGPVKRSSLEVLRKAAKDLDIPVLYTRSVGFYSIFSLQLPAAFPIVETHPDPESTQDLRLLNPWPELAAAGAGISNLDSLDDHQHGHVPYVLLLLHHLELWKKAHDGQVPSNYKEKSEFREMVRSSARTSNPEGGEENYDEAVAAVLKSLNPFTLRSSIREIFEMEECRRPSPDSADFWVIAAAVREFHQRHSVLPLPGSLPDMKAQSSDYVSLQNIYKSKARKDIEEVTEIVRSVEVQLGSRPIQVSDKDIEVFCKNAAHIKVVHGRDIPLVNGEAYTLEAIRNNLSVPDSLIPIFIAFQILDNIVTDIQDGERSEEALDDEIAWESAIKHVLGMLKSEGPSAIEEEDARERILQAARELRRTQGGELHNISSLTGGLVAQEALKVITRQYVPLDNTCIFDGAHSRSEMYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4C3</accession>
    <name>A0A317X4C3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine rich repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_341970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470177.1">
        <property type="nucleotide sequence ID" value="XM_025607044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4C3"/>
    <dbReference type="STRING" id="1450535.A0A317X4C3"/>
    <dbReference type="GeneID" id="37109187"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="658" mass="72270" checksum="36A0EF908752B8D8" modified="2018-10-10" version="1">MSAATPVPLAIQKQPLPQYSTAVSGDASPIEGSCTASPHSSACSSSQNSRSSSRRRESFGSIKEDVDGIAQSFVDTHLEDSPQEPPKRNPLEMQPDFCCPCGGFLGWKQIRLGGKSLSRSYSDLRGLGNMQARGWAWDSTPPVVSPPSKPAPVEEKEVQQLQVPEEPKEVVVEQKPAAGTSALERLPPEVLDHLISMLALDVPPNGYTPRNVDLIACLLTSKTLHAATLSVLYRNMTFPHSIIFSKALNHIARYPALGTLVRRLDFSHFTSVGLGRTKQMNAEIQNLTSKTLLQCLELLPNLKECLLQEHVEGDISLEVLQKLFTGLPNLFAVDFCGCSSQSFSGLFLEALISGPPGLPMTLPNLRRVSLHECSSLPAAAFEILLPRLINLTHLDVTHTQISEDALFSIPHSAKITHLSLSRCSRLRGSRVVEFLSTHPAVYDSLVFLNLLTDPARSRILEEEDVQALLPKLPTTLRSLNLGGAKVTSAHTKALVPLTKHLEELGLSSCELTGQDINTFFVPPKPNGESSASEPWVPSTLCYLDLNRANQLTIGTIFNPNSCVILTPQSYPLQVIEFSDKLIAPLRERSRNARTSPGWAVRELGRRGWYVREKSTMPEVMPDDGARSWKMGARWWGMRKIPVAVGDVGGLYGHYMFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4E3</accession>
    <name>A0A317X4E3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_543655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470197.1">
        <property type="nucleotide sequence ID" value="XM_025613145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4E3"/>
    <dbReference type="GeneID" id="37115288"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="436" mass="47921" checksum="F3149169F16DA247" modified="2018-10-10" version="1">MLTNGVLFGGEMLIRGEQTSDEAALSMQGSSPSTQCGIQTSDRVALNMWVCSYSTNHDPRREEMSTANYLLNAITRSKAVGLAHIGGDVNCGLSTNEMCSRGEMSTAVYMHPMELLKPRVTCCLCLGCELRGHQSWAFQRGDVKCGMYVSDYSKLPGRDRLCVSTNDCTYCQSDGVYIGDVNCEGMSTAASTHPTSRSKHAGLTPSPNHISPTGEMSTAVSIYPKGHSKIMIPAPGTQSHRHNLCSITPVPVHQSYLSNRRDVNRGEHVSGQATLFINPAYPYQSYPLYWRDVNCGIQCGKCVTYIITLNPHLLYLSTNDTYSTGEMSTACTRELQQAGIRISCSKAAGLHLSTNHTSSTDEMCQLRRDVNCGNHTPVNISLGISLYLSTNNICWDGLSFRGQRYIALVYWWDANRGNHVPDKRSNHPSDSTVLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4R7</accession>
    <name>A0A317X4R7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_543778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470327.1">
        <property type="nucleotide sequence ID" value="XM_025613153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4R7"/>
    <dbReference type="STRING" id="1450535.A0A317X4R7"/>
    <dbReference type="GeneID" id="37115296"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF5">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16998" checksum="58D87CB0069D50C6" modified="2018-10-10" version="1">MHNFSAPIKDRILMNELGGLLLIERSHSSLSKSSQRVIKALRELMSTVYSPSQRGYHVLVDAINCLKKLLAEIDSAVDIVLITYMWFCEVALGFIECLQQYNSLTLAILAHYCVALHRLRTHWWISSWGERTLDVIVKSLSPNWQPSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5H1</accession>
    <name>A0A317X5H1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_554521</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470574.1">
        <property type="nucleotide sequence ID" value="XM_025613721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5H1"/>
    <dbReference type="STRING" id="1450535.A0A317X5H1"/>
    <dbReference type="GeneID" id="37115864"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11 12" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="409" mass="45059" checksum="434BA2E851E4C5BE" modified="2018-10-10" version="1">MKSLQFARRRALQGLVAPRAFQNPATTQLFKRCFSATPAAASQLAGLDPAKLTVSKTNTPKELTAPQDLVFGKTFTDHMLSIEWTAAEGWQTPRIVPYQNLSLDPSACVFHYAFECFEGMKAYKDKDDQIRLFRPNKNMARLNKSSSRIALPSFDGDALTKLIGEFVKLDSRFIPSERGYSLYLRPTMIGTQKTLGVGPPGSALLFVIASPVGPYYPTGFKAISLEATDYAVRAWPGGVGDKKLGANYAPCVLPQLEAASRGFQQNLWLFGEEEYITEVGTMNLFVALKNKETGQKELVTAPLDGTILEGVTRDSVLALARERLVPKGWTISERKLKMSEVAEAAEEGRMLEVFGAGTAAIVSPVRTISYRGKSVDCGLKENEEAGEIALQMKNWIEGIQYGDESHPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5I4</accession>
    <name>A0A317X5I4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_554542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470594.1">
        <property type="nucleotide sequence ID" value="XM_025613724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5I4"/>
    <dbReference type="STRING" id="1450535.A0A317X5I4"/>
    <dbReference type="GeneID" id="37115867"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="42"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="265" mass="29575" checksum="90870E1E5CC9E6C0" modified="2018-10-10" version="1">MVHREQTLQLPHAYLHLHLPADMEPSYAPLCAQQHLEDNKIHVLLAASGSVATIKLPNIAEALGRHSNVSIRIIVTKSAEKFLAGQSSEQPLLENLRQIRGVDAIYRDDDEWKNPWTRGEPILHIELRKWAHVLLVAPLSANTMAKMTMGFADNLLLSVLRAWDTTGTVDASFKDKKPLVFVAPAMNTAMWNHPITAKQLAILIDEWGLDACNNKGWVSVLHPTEKSLACGDTGNGAMLDWNVIVRIVEQYIGVNEGDWLMEQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5L7</accession>
    <name>A0A317X5L7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_511349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470386.1">
        <property type="nucleotide sequence ID" value="XM_025609763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5L7"/>
    <dbReference type="STRING" id="1450535.A0A317X5L7"/>
    <dbReference type="GeneID" id="37111906"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07729">
        <property type="entry name" value="AHL_lactonase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF2">
        <property type="entry name" value="102 KBASES UNSTABLE REGION: FROM 1 TO 119443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="64"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="292" mass="32622" checksum="3B463C9B809C6382" modified="2018-10-10" version="1">MATSTDPASMLVSAGIPAFKCPPGTKMYILDLGTLQIDESWILRGANVSTLSNPNPVNRRRDLILLSALIDYPGVGLILFETGCAEDLDVKWGAPITDIFPRTVYTEKHKLPAAISATGHSIKDVKAIILGHLHLDHAGGLEHFVDTDVPIYVHEEEFKHACWAVATGADLGVYLGHYMLLERLKWVTFPEERLDLYQGITLHHCPGHTPGLCVMQVNLERDGTFIWTTDQFHVKENYELGHPHGGLARDHNAWYRSLGLVRRLQRLFGARLVFGHDLEVARGLMEESDVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5W5</accession>
    <name>A0A317X5W5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">2-oxoglutarate/malate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_384215</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469668.1">
        <property type="nucleotide sequence ID" value="XM_025607280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5W5"/>
    <dbReference type="STRING" id="1450535.A0A317X5W5"/>
    <dbReference type="GeneID" id="37109423"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="123"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="222"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY91940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="315" mass="33894" checksum="D04E3644EEA016D7" modified="2018-10-10" version="1">MASPTAAKDAEPAVNFLHHPYTRAALPFVNGGLAGMTATVAIQPIDMIKVRLQLAGEGVRTGPRPSAIGVARDIIASGKVLDLYTGLSAGLLRQAVYTTARLGFFDTFSKTLNKRAEAANRTVTFAERAGAGLSAGGIAAMIGNPADLALVRMQSDGLKPVEARANYRSVLDALFRISKHEGVAALWAGAFPTVIRAMALNVGQLTFFAESKAQLKAHTSLSVQNQTFAASAIAGFFASFLSLPFDFVKTRLQKQQKDPKTGRLPYKGVLDCARKVVKEEGWLRFYRGFGTYYVRIAPHAMVTLIVADYLNLITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6X4</accession>
    <name>A0A317X6X4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_328510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471084.1">
        <property type="nucleotide sequence ID" value="XM_025606957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6X4"/>
    <dbReference type="STRING" id="1450535.A0A317X6X4"/>
    <dbReference type="GeneID" id="37109100"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="512" mass="57859" checksum="660C41E8EABCEFD3" modified="2018-10-10" version="1">MERTPIPSPSQLALAMAIVKLKPVGLDIKEHLLQIRRHIGTTHRTDRFYTHDKYLDSVSFWQQAYEQSEAEQSKLLERIFELEQRNESLLARLQGTGVTGEEGTLKRKVTGKSVASGNDAPIRKRAKTQIFPQTDSLMLANNVSDGLGGGAIDHLQFPEQFTAPFMRQFYTLQKVLQKRPNNSSIIRAAIELCSTAVGNVRSAIKQPTESRASTKNLTQPKRPNILAILNSTECAFRLLVQALRKLSTTGRAMQDVGHVTYHIVRLYEVIIEVLDRHCKSKSEKSLQDTKTGAQTSRQRQKAKPKRTKTGCSSDVQKDPDYELANQMSLLLSKMALSLDTNRLSEQNVLEGFLLILLDRIGTLLCLFVFQDLRLRPDLQIDEAKFPLPEGLKEIDLNENSINAAAMEAKFLIWPLERILTVLDDVPGHDPLSTQFTTKVKERLQSTLLHSVFGTDSLWPDVLQRPVQPDDADLEKLRSCLQIPEQSVPDWFVQEVWRLLGWEMLATSNSSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8D7</accession>
    <name>A0A317X8D7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_531822</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471635.1">
        <property type="nucleotide sequence ID" value="XM_025610985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8D7"/>
    <dbReference type="STRING" id="1450535.A0A317X8D7"/>
    <dbReference type="GeneID" id="37113128"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="56"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY94874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="385" mass="41660" checksum="B1B13029A03B2BEB" modified="2018-10-10" version="1">MIAARNFVTPARQCLRTTRVSPSIASPFSQLRSYSVAADDRVAKFKGQKGPDGKYTVTLIEGDGIGPEISQSVKDIFAAANAPVKWEPVDVTPILKNGKTAIPDDAIKSVQKNYVALKGPLATPVGKGHVSLNLTLRRTFNLFANLRPCRSVAGYKTPYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITKEASERVLRFAFQYARSINKKKVRVVHKATIMKMSDGLFLNLARDIAKEFPDIEFDAELLDNSCLKIVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDECSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLQHMGLTEHAARIQKATFDTLAEGKALTGDLGGNAKTHEYAEAIMKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8M6</accession>
    <name>A0A317X8M6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_364470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470019.1">
        <property type="nucleotide sequence ID" value="XM_025607193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8M6"/>
    <dbReference type="STRING" id="1450535.A0A317X8M6"/>
    <dbReference type="GeneID" id="37109336"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000018">
        <property type="entry name" value="Cell division cycle protein 27 homolog B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="127"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="517"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="585"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="619"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="653"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="755"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="254"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="280"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="882" mass="98269" checksum="D802B40BE7DAC0F7" modified="2018-10-10" version="1">MSPSTAHVSSQLRQLIYYHLDNNLVRNALFLAGRLHAYEPRASESSYLLALCHLQNGQVKAAYDYSKNFGSRGTHLGCAYVFAQACLDLGKYLDGIKALDRSKGLWASKNHWGKHSETRRQHLPDAAAVLCLQGKLWHAHNQLNTAVECYAEALKLNPFMWDAFLGLCETGVNIRVPNIFKMTPDLNALVSSASQEDSDFSSDKPVSTSGPLQTQAKLNSSVDPFTTATSRSEAITTHGSSALWEKLNGSTVSVASTGAPTAPAVREGTETPGAQSSESDDVRGAHRSDPSWEPPLAPARKNRTIQTINADHTMDSPPKMKPTGIRPRTRTKAEVEEQAATHAEREVTHGSRVGDRKRTVSGSVAHSASQPTEPGAPQRRSVRLFNQIKPTTSKLSSTTLGAKDVRELKKVRSTGAKGRTTATTSVGRVVSGNRKHLNDAHDGESKEHRPATLVPNGVHHTSSRGASLDRSKAVEALIWLLELFSKLASGYFALSRYRCAEATQIFAALSQGQRETPWVLSQIGRAYYEQAMYSEAEKYFVRVKTMAPSRLEDMEIYSTVLWHLKNDVELAYLAHELMEIDRLSPQAWCAVGNSFSHQRDHDQALKCFKRATQLDPHFAYGFTLQGHEFVANEEYDKALDAYRHGISADSRHYNAWYGLGTVYEKMGKLDFAEQHFRNAANINPTNAVLICCIGLVQEKMDNPRAALAQYGRACQLAPHSVLARFRKARMLMKLSELKLALTELKALKDMAPDEANVHYLLGKLYKMLHEKANAIKHFTTALNLDPKVSLILEDPIWKGRANWICRRPNTSRTPWSRWMTTKKMTKIWPDCFFLVVTILLRLPVNCGLVPLYPVQYWRGGGVFPGLNLCKHQHYEGVSRRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8T7</accession>
    <name>A0A317X8T7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_581364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471777.1">
        <property type="nucleotide sequence ID" value="XM_025615399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8T7"/>
    <dbReference type="STRING" id="1450535.A0A317X8T7"/>
    <dbReference type="GeneID" id="37117542"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="44"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="161"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY95016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="283" mass="31371" checksum="A170CB92F41D2828" modified="2018-10-10" version="1">MTFSPTTTTNTNPNPNLNLTNTPTTTTTTTTNLNPTPKPSRLPRITPILPGLYLGNLPALQTPTLLHEHNITAIVSLTTSPWVQDPTLLLEIGIPSSHHKCLPVLDSLVQDLLRHMSEICEFIDEMACPELRACTTLPNTNKDVDEKAVVTGPAEPETNVSGEWGVLVHCDFGRSRSATIIIAYLMRKFKISVDEALGFVLARQKVKPNKSFLGQLGVWGEVGYEVWVGENDDDDDGNMYAFEDSDGEWERGKGNGKGKKVPKKAYGEYLLDRSERLWEMGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X921</accession>
    <name>A0A317X921_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">BO94DRAFT_218824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X921"/>
    <dbReference type="STRING" id="1450535.A0A317X921"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY95113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="432" mass="45848" checksum="9F82BBDC7AA2C116" modified="2018-10-10" version="1">MSDRASSASFRVGPPSPSSPAAGSLKQTQPLAYLSDHFPQSPTSPPLMSVSAQNYASHLVSSQASPNQATPQPANLSSPPSSAPMSAQASQQPPVGTANSFPTPASSVSGHIPSANSFDDSENFDKPIGPGIGDTSATTATMNAVAMQQAEHRRTDHDRQPGGMDIGVRDFAVGGASDAMEIDSEVPASSIRSGPSLESLQKDFSSAFHLCKSSHIATGPDPSLDLISLYGLGPVAKSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPVKNEPGAPGGLRHMTMWPEEEWQNQKVFGKEIRVADIDSALHNLQMKAMKMEPGTVPNNEYWEDVLGHEKPSKHAGGGDAGKKSVAPPPNGIRVTQPNGTPVPFSEPDRSRPSRGRKRHYDDNSFVGYGEGYADDDDDGAFYSNSEGMGKKKRKKVPVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9B1</accession>
    <name>A0A317X9B1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell wall glycosyl hydrolase YteR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_458235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470958.1">
        <property type="nucleotide sequence ID" value="XM_025607783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9B1"/>
    <dbReference type="STRING" id="1450535.A0A317X9B1"/>
    <dbReference type="GeneID" id="37109926"/>
    <dbReference type="OrthoDB" id="540611at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF11">
        <property type="entry name" value="WALL GLYCOSYL HYDROLASE YTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016385681" evidence="2">
        <location>
            <begin position="25"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="416" mass="46772" checksum="B77DD6A9B46471A7" modified="2018-10-10" version="1">MPGIISFTAVLLSGLLAQSHLVAAVGRACDSESRPYSTWMTDSVIARRDAILDSSTEDDVSIVFKIALFESTVIRLKEYYDADSCGQEDWHSYLLEGAESLLPRVVNVTADINAPLDVFATGDALYHQYDRNSNETYKQVLDTLHDALNDRTRNSEDGFWYYNAYPNLSFLDGSFPLSSFSSLWKTYFSPTNTSIADDLMNNLDLFKDHCHDDSSGLLFHGYDASKSAWWADPTTGASPYVWDRALGWWHMALVDLLERSDRNNILNETQRDDVYTKYWNLANTIINDADNSTGCWWQVMLHGGEKGNYIESSGSSMFVYSLLKGARLGYLSGSTPNGVGYTDAADKCYNYLVDNFIKEESDGTLGMDQTVSVCGLTNPTYEYYTSQPIDYNSVYGTAPFILASWEHEMFTTGYYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAE3</accession>
    <name>A0A317XAE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_509862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470669.1">
        <property type="nucleotide sequence ID" value="XM_025609715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAE3"/>
    <dbReference type="STRING" id="1450535.A0A317XAE3"/>
    <dbReference type="GeneID" id="37111858"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="347" mass="39379" checksum="35CDB3C5EF69D9DF" modified="2018-10-10" version="1">MRLSYRIGAAALIILAIILIKRHLDLVQDDARVQSGWSFSSFSAESVADTSSNSNGNGNVNINNVNPDSATDPNTDRVSTPKSSKPKLTGSDMTNSKDSDSVSRPVYETTPIIVPNDRVIVMARLSTEDTSWVSTDLNEWRNVIYTVDDINASRHTPKNKGREALAYLQYIVDHYHDLPSTIIFIHSHKDGWPGAWHTDTMAYSNVDSIRALQTDFVQRNGYVNLRCQQSPGCPDEIRPFRDPPQFGRTTERVYAQSWIELFNNTDVPEVVGVACCSQFAVSKEQVLKRPLDHYQWFYDWVLNTGLSDDLAAHVMEYSWHIIFGQEAVYCPDAYQCYQDVYGNPYFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAW0</accession>
    <name>A0A317XAW0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Protein phosphatase methylesterase 1</fullName>
            <shortName evidence="7">PME-1</shortName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_530475</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48548"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="3.1.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472497.1">
        <property type="nucleotide sequence ID" value="XM_025610679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAW0"/>
    <dbReference type="STRING" id="1450535.A0A317XAW0"/>
    <dbReference type="GeneID" id="37112822"/>
    <dbReference type="OrthoDB" id="194865at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051723">
        <property type="term" value="F:protein methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000186">
        <property type="entry name" value="Protein phosphatase methylesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016812">
        <property type="entry name" value="PPase_methylesterase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14189">
        <property type="entry name" value="PROTEIN PHOSPHATASE METHYLESTERASE-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022950">
        <property type="entry name" value="PPase_methylesterase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0719">Serine esterase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="110"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="40"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR022950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR022950-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY95736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="412" mass="45087" checksum="53E5A7703F33CEF1" modified="2018-10-10" version="1">MSELQKSFAKSRLAKLPLQPPAGPSMQPLDEEASHDDDSSSASSTGTVVPSPSRQLFARPGRGSLQPTTLPWTDFFTQELYLTQIDITNNIKTTHHVYLTPPVDPTSPLFVMHHGAGSSGLSFAACAEEIRKIVPKAGILSVDARDHGSTAVTTASGEETHIELDLSLDTLNRDLVFVIRETQSQMGWESLPDLILVGHSLGGAVITDVARKGELGGKVLAYAVLDVVEGSAMDALQSMETYLSTRPSRFPSITSGIEWHTRSRTIRNKTSARVSVPSLLYEDPNPPDPTKPWIWRTNLSETKPFWENWFVGLSRKFLEARGGKLLLLAGTDRLDKELMIGQMQGKYQLQVLPEAGHFIQEDQPAKTAQILVDFYRRNDRSALVLPPKVADMQASAAMKKGAGGFGGPFKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBA8</accession>
    <name>A0A317XBA8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_554047</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471009.1">
        <property type="nucleotide sequence ID" value="XM_025613692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBA8"/>
    <dbReference type="GeneID" id="37115835"/>
    <dbReference type="OrthoDB" id="3431704at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="84689" checksum="58CA849562D93E67" modified="2018-10-10" version="1">MEPPSKNRIRKTPPVSAAAPRKRRKRTVVSQAADDCFSCARQGTPCDRRRPYCSQCLDSGRSCAGYKTALTWGVGVASRGKLRGLSLPVTGAQPAVAPSKPHRVTGPRPGSKSKQGSDSAAEKSRLHDKQRCSVSGRAANTASNTSAPTSQVRLCSPTDSFLARPRRSESLTQRHSAATVSNTQSTETWMRPVQSPQTTQCSWHGQRLEQEVDSVFDEQTEAVCPEGIAPWTTSFQPPSLFQQLLARSVGRTPRLRYLISYYAEVIAPMIVAFDSPTNPFRTYILRLAEESTSLQEAIATLASCNLRQRRQRGTRSTERTLPARMSSLAHQALTVEAFQDRSGLPVSGGPTLEEQYHRGMAVTALNRELADSRQRLSDSVLATLLILCLFHGCDTGVAQFKTQFAGVTKLLAIRLCNSPCMSDELKWFVRMFTWIDTMTATTNDREVQLRGACLDITAVSDGEWGLENLAGCDAGLFRFVAQLGRLNLLSQNQEVRTTSPPDIQMPSTTLPPSMAYCPSDMSGTSYGPSGFPLPPAPCHHDGSQLSPAFWAEWHSLRQKLESWRFVPYRQRSGSSFGTTSHPYISPPSSPSDQSAVAPHNLKDVIHTSESFRHAAILYSERLAYPDLPSGHPRIQTIVQRTMSHILSVQCDAYLLWPLFITGSECVLADHRAIIRQRCKDLSRDSGFFNNLSCLELLERIWAENPGTSLAPGLHAAVGPVSEAGLVPPGGWALPDEAFMSPAPATVSRKQGFRWHDAMQTKRAEGEYMTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBE2</accession>
    <name>A0A317XBE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Autophagy protein 16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_482815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472637.1">
        <property type="nucleotide sequence ID" value="XM_025608906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBE2"/>
    <dbReference type="STRING" id="1450535.A0A317XBE2"/>
    <dbReference type="GeneID" id="37111049"/>
    <dbReference type="OrthoDB" id="8949486at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22887">
        <property type="entry name" value="Atg16_CCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013923">
        <property type="entry name" value="Autophagy-rel_prot_16_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08614">
        <property type="entry name" value="ATG16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy-related protein 16" evidence="4">
        <location>
            <begin position="7"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="82"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="152"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="205" mass="23154" checksum="CC8AF5A24AC788D7" modified="2018-10-10" version="1">MAHWKEEYSAALAARDRREKANIAIYDAYTQLADRTGRIAAAASNPQSPVPTQGQQVPTDTSGSRSSKQTSGAQDPSLQETLLATRADLSEAQRSRSELQDRLARVTVELEKLRKRNTQDSRRIHAYGGEVAHLQLRLKDRDEELRGKAKLLDDFQDELASLNLQLNMAEERTSRLERENQELVDRWMARMGREAEAMNAASQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBF3</accession>
    <name>A0A317XBF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_572005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472202.1">
        <property type="nucleotide sequence ID" value="XM_025614899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBF3"/>
    <dbReference type="GeneID" id="37117042"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016342023" evidence="1">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="105" mass="11226" checksum="C890EB2876A07D21" modified="2018-10-10" version="1">MPSSPPSLIPLPLLLLYLTLPTAATTTTCYDPTGTKLHAGYQPCPPSSGSPNSCCNIGNGDLCTDSGLCLRQDTLANGFWYQDGCTDRDWRGCRRICSGKIVLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCG8</accession>
    <name>A0A317XCG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_572212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471409.1">
        <property type="nucleotide sequence ID" value="XM_025614909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCG8"/>
    <dbReference type="GeneID" id="37117052"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20483" checksum="838488F27FD117A8" modified="2018-10-10" version="1">MFIHGLQGHPQLTWSTKIRKPGVKPVFWPRDLLQEDAPECRVMTFGYDSSVAGWGTCNWGTIVQYARDLRFALDRQRATCPNRLLFFVAHSMGGLITTTLLKDWQIGGHTSELKNSVKGFLFLGIPHCGSKHAAWALRVSGFFKLGAVAGIATNLKNLRALYPHTQEQQDLLQEFQEKWKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCZ9</accession>
    <name>A0A317XCZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1771-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_572364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471589.1">
        <property type="nucleotide sequence ID" value="XM_025614918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCZ9"/>
    <dbReference type="STRING" id="1450535.A0A317XCZ9"/>
    <dbReference type="GeneID" id="37117061"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="99"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="299" mass="34079" checksum="D9A21FFEBA1998EE" modified="2018-10-10" version="1">MHEHELSYMGPRAFSHDQSQDAEAEYDRLRDLARQEASQRNSCFQRSQEAYSSGDGAKAKELSEQGKAHGRKMDDYNKQASDFIFRENNADGRVAADTIDLHGQFVEEAEEILEERIKYAKSHGQDHLHVIVGKGNHSVNHIQKIKPRVEQVCLELGLQYATEENAGRIYVNLTGGPADLATAPVPSHPHYQQHQQHQQHHQQSSGSYAHPQHAQAQQGTYAHPSHQQQPSYAHPHPEQEQTQQQYPSHQQQQYPQQQQQYPQQQQQQQGGNQDEIEQVVNAVLPKVLRKLEKACCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDI9</accession>
    <name>A0A317XDI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_580953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472553.1">
        <property type="nucleotide sequence ID" value="XM_025615357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDI9"/>
    <dbReference type="STRING" id="1450535.A0A317XDI9"/>
    <dbReference type="GeneID" id="37117500"/>
    <dbReference type="OrthoDB" id="4505928at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="26745" checksum="3A4F80016A554033" modified="2018-10-10" version="1">MEPNKNQKNLDRLARIRENQRNSRARKLQHTRELEQKLAALQEQARLRDVEHRLAMQKLEAENRKLRHLLTRSGLASDSIEKYLHADDLASTEKLAIPNLRRPEAECQPYRVRPCSSTTNDAATRATGNALDSNSAIKPESRTLLQGIESQGSARDTVCGCAPNEAIASWPSNEDVLNTTLCAIADELIDQYNTRGVDMEEIRRKLWAGFSKGLTTEEGCRVQNHILFQVLDEISNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDQ7</accession>
    <name>A0A317XDQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_580472</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473404.1">
        <property type="nucleotide sequence ID" value="XM_025615330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDQ7"/>
    <dbReference type="GeneID" id="37117473"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF250">
        <property type="entry name" value="MFS-TYPE TRANSPORTER AFUA_1G00970"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="18"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY96643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="407" mass="43384" checksum="DABA679679B1CEAD" modified="2018-10-10" version="1">MGAHEDPSSSTPSEYTPRACLTLLGSFCGMFCTVGFMNSFGVFLEYYKTAQLSDQSESTIAWIAAIVIFFIFGVSVISGPLLDTFGPKLLLCIGSLGTVFAIMMTSLCKEFYQFILAQGILLGISLSLLTCPMIALVGQHIKIKRGAAIGIVVAGSSLGGVVWPIVVNELLQKPSIGFGWTMRIVGFIMLPLLIITCLCCLPPPSPPSIIPPNTLPQTPESTSTTTTTTTTTIKEPSLLRSPPLQLTCLAFFFIYFGMFSPFFYTTSYAISHGFSSNLSFYTVSIINGASLFGRIFAGVIADKYGRFNCCVIFTLLSGIIALCWTKATTVGGLVVYSAAYGFTSGAILSLQQACAFQLATPRTVGLAVGVVMASTALSAMAGIPISGELSQKYGYLALSIYAGVRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDQ9</accession>
    <name>A0A317XDQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vps26-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_483538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471819.1">
        <property type="nucleotide sequence ID" value="XM_025608923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDQ9"/>
    <dbReference type="STRING" id="1450535.A0A317XDQ9"/>
    <dbReference type="GeneID" id="37111066"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="351" mass="40568" checksum="B6EE36AEFE7345D7" modified="2018-10-10" version="1">MTSLFFSTPLDIDVVLEDSDERQTVDVKLDKGRRERVPLYMDGESVKGAVTVRPKDGKRLEHTGIKVQFIGTIEMFYDRGNHYEFLSLVQELAAPGELQHPQTFPFNFKNIEKQYESYNGINVKLRYFVRVTVSRRMADVIREKDLWVYSYRMPPETNSPIKMDVGIEDCLHIEFEYSKSKYHLKDVIVGRIYFLLVRLKIKHMELSIIRRETTGSAPNQYNESETLVRFEIMDGSPSRGETIPIRLFLGGFDLTPTFRDVNKKYSTRYYLSLVLIDEDARRYFKQSEIVLYRQAPEIAITPQIAQQQQIQQQQLLQQQQQQLPAGSATAGPGRGGDHQPQFSQQISAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF65</accession>
    <name>A0A317XF65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_620799</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472101.1">
        <property type="nucleotide sequence ID" value="XM_025616957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF65"/>
    <dbReference type="GeneID" id="37119100"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000018">
        <property type="entry name" value="Heme/steroid binding domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="4">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="255" mass="28767" checksum="4819FB16DFCEC084" modified="2018-10-10" version="1">MSSELRQRQKQSSSSKSPPKPKPSTPSNNNNARGISILDFLRVLATLIIATLGLSYYMTGSESVLFGYRPWFTRWPVVLRYIEGPLTLTPSQLSLYNGTDLTLPIYLSVNGTIFDVSANPLVYGAGGHYNFFTGKDATRAFVTGCFKEDLTPDMRGVEEMFIPIDDPEEEKKLSSGERKTRREQDLRIARQRIAKQVAHWEGFFRNHKRYFEVGKVVGIEEFVEEERAREGGRSGSFVRRRGSRGGGGMLLGRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFV5</accession>
    <name>A0A317XFV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_580546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473478.1">
        <property type="nucleotide sequence ID" value="XM_025615332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFV5"/>
    <dbReference type="GeneID" id="37117475"/>
    <dbReference type="OrthoDB" id="4460827at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="66" mass="7938" checksum="F19573D7D6EA5DB4" modified="2018-10-10" version="1">MAQLIENIINPDIVGYIRKEKLEARLRIVFGYDIRVRHVNERFVFDAPRLVTRDEIDDLREIDRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFW2</accession>
    <name>A0A317XFW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_19917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473543.1">
        <property type="nucleotide sequence ID" value="XM_025606091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFW2"/>
    <dbReference type="STRING" id="1450535.A0A317XFW2"/>
    <dbReference type="GeneID" id="37108234"/>
    <dbReference type="OrthoDB" id="3429912at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000078">
        <property type="entry name" value="Putative Zn(II)2Cys6 transcription factor (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY96782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="736" mass="81165" checksum="DEF59F4B04F6DD21" modified="2018-10-10" version="1">MDSSTALDPRASHGRQAACLNCRKSKVRCNRSQGDAYCGRCKQANVECVIPNHHVGRQKGVKNKRKGLEKAIHQIEQAIKRPRNDTSGAETAHKLISDLQDLLSNTREKQLDSEVDDRSEDLNRPYTYPSPQDNNAGENLSLDDAENPLQLLARASDLQLSPTEVRDAYRWPPSTYPQHTEVPQSNINGSVPAAQAYFVPIRASLDIGLDIDPIDIGLITLNEAESLFSFFYQNLAHTRWGLDPLVHTVSFVRSQSAFLFTSIMSATALFLPSATALSKRLSRHCKALAQNVIARRHRSVEIVLAFMVNVPWMEPGSCLGDDDTCSYIAMALAVALDLSLNKIVLPSTSFDHGLLKRLAKAESIDAKRALYVDGFDGIDPDSDWGRRLLRRRERTWIALFVLERGVCLARGRSYTVPSTALVDHCDKWHVSDFADSRDGPMNSMAVLRRNLDGLFQRVKANCDSHQITDVGSEVAHSIKNMIESFYDQWSEVWAPEIGEGQSYSLPPYVEILVTHTRLSTYSGVINHPTAPVEVKRFFRAAGLSSALNVLRAAIQGESRLKSMPNNTVIMISFAACSALSLSMMPADCRSSLAPSVHNLIEETAGVLERIGDTPRHRNGASVLYGRFLRALVRRFPVSSGSQNPNGPRTLADTGTLHPPSDMDGYCPVSSGAQASSISPSIIWPEPLRFSTMSDDQIIDAVNRAGTAFGTNVPDVPLDDLMSWDWFDVGNAADFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XG38</accession>
    <name>A0A317XG38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO94DRAFT_1156</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472919.1">
        <property type="nucleotide sequence ID" value="XM_025605535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XG38"/>
    <dbReference type="STRING" id="1450535.A0A317XG38"/>
    <dbReference type="GeneID" id="37107678"/>
    <dbReference type="OrthoDB" id="6600518at2759"/>
    <dbReference type="UniPathway" id="UPA00799">
        <property type="reaction ID" value="UER00773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00802"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PWY96158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="585" mass="65733" checksum="6AC00B255CDE3B31" modified="2018-10-10" version="1">MVLDYLFFHCTYTIPLATALTVLYYPFFTPQDLSKICILITIAVIATIPWDSYLIRTAIWTYPPDAVIGPTLFRIPIEEVFFFVIQTYTTSLVYCIFTKPLVRPIYLRSDGNKRLRNGVAVGILGLMSIGIACLLSGEWTTYLGLILVWVCPVLLFQWYVGSLSEGGCLLFRILSYPFLTALPWKQIVVSVCLPTMYLWIADARAMGTGTWRIESGTKISYQCYGLEVEEATFFLATNIMIVMGLAGCDYAFALEEYRGLSEPASKSSLKGAILGLIKPMPVDGRLVSALSQAVSCLKEKSQSMFLGSALFQGQLRIDLIFLYSFCRVVDDLIDEAENEHEARYWLTQCKNILDARMNNEHPDGQLKGGKYGTLCQSIDFLPLSRLSKEPLYDLLKGFEMDLGFNPEKGTFPIETERNLDQYTAYVAGTVGALVLDVIFSHCYHERTPRMAEIRNAGTEMGMAVQCVNIARDIRRDAAIGRVYIPTTWLNEVGLTPGDVLQSPSAPVIYELQNKMLQKADGYYRPSRVAIEELPIGVREPVRATAESYMEIGRLLRETKGKNLDRTTKLRVSLRGRLVVGWLAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XG51</accession>
    <name>A0A317XG51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_530561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472591.1">
        <property type="nucleotide sequence ID" value="XM_025610702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XG51"/>
    <dbReference type="STRING" id="1450535.A0A317XG51"/>
    <dbReference type="GeneID" id="37112845"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="112" mass="12332" checksum="EA05D17671B08F84" modified="2018-10-10" version="1">MQPDGRFSIKNGAKTLYNDLTAEEAALWESRLIPQSYLVQTTCVTRAAYEYIPSTYLVCENDQAAPPQYQEMFAALAKAEVDRCSAGHSPMLSQPAMLVEKIAAVADRASEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGB1</accession>
    <name>A0A317XGB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_455523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472641.1">
        <property type="nucleotide sequence ID" value="XM_025607662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGB1"/>
    <dbReference type="STRING" id="1450535.A0A317XGB1"/>
    <dbReference type="GeneID" id="37109805"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="503" mass="58277" checksum="1D3A1649157B3D0F" modified="2018-10-10" version="1">MGLIQRVTKWLPSSPSLPLDDSSREKGRNLSRFAFFKRRIRLKGNSSISIPLGFVLLFPCLVIVLILLLFVRHPSSPGGILIPAGTPPSIRKISEKYDRVFATGCLPVEKTDTPRANAAFVVLARNKEIDGVVQSLKSIERHFNRWFHYPYVFLNDGDFDDAFKETVKNYTSAPVEFGKIDDSMWGYPDWVDHEVAKEGVRKQGDAAIMYGGMESYHHMCRFYSGHFYKHPLLMKYEWYWRLEPEIKYFCDITYDPFIKMAEANKTYGFTIAVKELRETVPNIFRYASAYKRKHNLASKGLWEMFLEKPEEEEPKPEEEKQEKLPEEILQNEPGENTVPDVDPEAMEGEKYNMCHFWSNFEIARLDFFRSKEYEEFFDMMDKSGGFWMERWGDAPIHSLAAGVLLSPGDIHYFRDFGYRHTTIQHCPANAPARQLPRIPWLEMTTEDEKERIEEDEYWANPDPVKENGVGCRCRCDTDIVDVEGKQGSCLAEWVEVAGGWASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XHB2</accession>
    <name>A0A317XHB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_580359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473281.1">
        <property type="nucleotide sequence ID" value="XM_025615322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XHB2"/>
    <dbReference type="GeneID" id="37117465"/>
    <dbReference type="OrthoDB" id="61370at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="207" mass="23309" checksum="1C29B246DA79E9DC" modified="2018-10-10" version="1">MDFHLVPRGEDRNYTGFLTKTIVYTASLIVFLASFGLTVSSIVVPKWVIYDDVDHHYSYGLHRRCSSVTGECESFPHREDCHAGDRYFCSMWRSVGFLMSFAVVLEGMSVVAYLIVLSGGKRLRESGWKILSLLIILSAVVQAASMSLVAYLFDNEERFFVGWRLSESWIYCTVSWCLSLFCAGVLILAAHTLPSEGGYELIPDQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UTB1</accession>
    <name>A0A317UTB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LMBR1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_540877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000060">
        <property type="protein sequence ID" value="PWY65254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461379.1">
        <property type="nucleotide sequence ID" value="XM_025613010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UTB1"/>
    <dbReference type="STRING" id="1450535.A0A317UTB1"/>
    <dbReference type="GeneID" id="37115153"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="657"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="564"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY65254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="680" mass="75523" checksum="C869696D1D4C8556" modified="2018-10-10" version="1">MISTSPVPVGSSIFFTLALLTISVLVLLLLRRFLTLRATPAYLSIPVFLALALPASVVLLVPIDLASSSRDGGGPTAIWLPDRLILVSWRIAYWLIFVLTWAILPLLGEYIDSGYREPKGRIQYSIRSNARYQLIVLCCATVGLIYISIQNGFEFTSIKTLVMALAYVWGLVLAIYLMGHGLVSIPRTLFRNANVSGRLRRIQSHAPKLHDRLMDAINDLESLESQVAQLQRRKTGTARDFQEWIEELAETANSPELRSGFLEQADGPGTVPAVITERYLADLTRRLQRARHQKARFVDEWDRLVLSAADMQAIINSSASTKLEFIHSPHRSSWVPSVNLLSPYMRYHLYVHIIPNVRLGLGAIFSAASVCVVWSELVKSLAPRLSVVTLSVVSYHKDPAPVGFGRQLIASAWLLYMCSAALVGVNDAKVWGNRALVRRNTYGESACWYAGLVARLTVPIAYNFLTFLPATVRQSTTFYKFLGRFIDLTPLGKGFDYFFPVFILLPIGATLFNLYGRVQNICSWGLIEEDDDDLENNPGGYGLGGWREGRDLIERELNGLGSLGLSARGSRSPRPASSIDEDTPAYSSSRTALLENPRTPRASRGTAATTPLMEDEEDEDNFLQSFAHRVRNTLETASKPQWLQGDSFRLPRWMGSEGNEGNSGLARWFGGRPAPGGVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWV6</accession>
    <name>A0A317UWV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_540626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461702.1">
        <property type="nucleotide sequence ID" value="XM_025612953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UWV6"/>
    <dbReference type="STRING" id="1450535.A0A317UWV6"/>
    <dbReference type="GeneID" id="37115096"/>
    <dbReference type="OrthoDB" id="5418899at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY66504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="686" mass="76988" checksum="80B32AF31213A1E7" modified="2018-10-10" version="1">MSSPPMTGQLPDSPSHRRLAARRETQRSRKGCPACRRRKIKCDEQKPKCGQCVRSGRSCRIIDSLFRPHAYSFLTGSSPRSHDTRPRSRSPDSPRGTPDVAWAAGSPQPGNAHSHVRLEVTNRFAVDLGGLHAPDTAPTSPTSPTPTNVLALVNAFTVVAPSEGFPVDRDALPVPTEPPILTTEPSPRQSHSDHGPRRPSHEQSRTPADPCLSQEDAIADSYQDRCEIAFFLRYFSEEPGRWMDLGNDTQYFSRYIVSLADMSALIRYAACALAAKQLGQVKDPESSIRQTSCHRTMLKAFSNSKLDFLWYGAKYYERAIQILARQISHEDRSDCHMSPACIYQSGLTPQSVDYSVLGDQEIAAATFRLLAACILCQYEDLSVTLRAWSGHLDGIYKLLRPHLSGAVELQPSHPIPQPANVVESIFWFLAINDMMDAFVSRKRTRINTDDLSVWRKFGGLPLDDTGSLIIHYTDERHAESILSKGLVRLLCLMVNANLANVMEWNYINAELDRWHSILPSSFLSPVSWPPSQSATQTDGSQPNAIPELFTRETWFSSDTCAIAMAFYHMARMVLLINRPLELFLQQQPHQLDLLATYRSLQEGLRHHASEIVPIAHGMPSDVVRKYLLQPLYVAGRCLQDISDRKSLLAILSQIDDDLGAFTDYRKRDLCEEWGIPYEPVERNIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYQ1</accession>
    <name>A0A317UYQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_504758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000057">
        <property type="protein sequence ID" value="PWY65647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461483.1">
        <property type="nucleotide sequence ID" value="XM_025609521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYQ1"/>
    <dbReference type="STRING" id="1450535.A0A317UYQ1"/>
    <dbReference type="GeneID" id="37111664"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY65647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="536" mass="60428" checksum="93DCC929D6784D38" modified="2018-10-10" version="1">MDSGLVLLSVALVEAYLLQRSLLPDWAFRSVTVLSLAGNLTLRLIWGLFVYPYFVTPLRHLPTLPGNLNHGRVLFDDPRGRLPLQWMKTIPNDGLIHFRDIFNRSFLLATNHQAMLDIMSTNTYDFEKPWRTREFLARIIGFGLILSEGGAHKKQRRALTPSFNVRHIRALYGLMWSKTGLLMEELEKEMDLNEGKVEMSVWASRLTLDIIGPAAMGRDFRSLQNPENKVADSFLAILEPTREKIAFLAINVLLPQWFARRLPWRLNHVIDTETGFLRELCKDIVLEKKASIVATQATAAELEADILGTMMLGGDFTDDELVDQMLTFLAAGHETTASAFTWACYLLTQHPEYQPLLRAEIRSRIPSGTSPITHSDLESLPLLNGIVQEVLRLYPTVPFTLRESIRDTTVAGTHVPHGTRVLLCPYAINRSPQFWGADADVFRPERWVDTDVSGNKLVNQHGGAGTNYAQITFLHGQRACIGKDFAKAELRCALAGVLGRFEMEMQDPKQVIHIAGAVTTKPVEGMHLRVRRVEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0Q8</accession>
    <name>A0A317V0Q8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_613834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461646.1">
        <property type="nucleotide sequence ID" value="XM_025616718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0Q8"/>
    <dbReference type="STRING" id="1450535.A0A317V0Q8"/>
    <dbReference type="GeneID" id="37118861"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="46"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY66382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="640" mass="72670" checksum="7B77F4694BCE7153" modified="2018-10-10" version="1" fragment="single">VFRLTREGRDESYESYRTRVRERIAGTCEWFLSHPSYNSWLDQPNDSLILSADAGCGKSILAKHLVDSKLDGRHPDAIICYFFFDQQSQNTARQALCALIHQLASRKFDLIKHTMSDYKASKEKLVNIDSVLWGILSRMVMDTSIGQVILILDALDECDQYESTRFINQLRELYLAWENKVVKKVTFLATTRPSSGTISELQSLITTYPQCHISAANCFGAIAREVDIVIEARATELEEKGRLDEDTKFHLVRRLQESSQRTYLWVHSIFEWIAATDVENGERAIDQIIDEPPKTVYDIYTKMVRTSKRPALARKAFSIILAAYRPLTLQEMHIAMHLDSVSSEPPEPYRNLELLLPNWCGLLVTVIENRVYLLHETAREFLVNEGFSADGQIQSGPLSEVETHQVLAWSCLSYIEVALEPPHLQSRNRSGNKSSESTSRALNEEFLDYVGENLFHHIQKAQLEEDKALAVRIKRFCDIQDRHCQVWTEAKPLQVRGLRVDSYNMSTLWIASYAGMTAVVEQLLEEGDNICDTRNRDGQNTLLVAALQGYDRILALLLTADQVRKDLRDAWRTGPLQAAVQSRNPAAVKVLLESGAVDVDTWDPSGRTPFDCVAADGDPDMIRVFLDFGSDEACNVRDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V1F1</accession>
    <name>A0A317V1F1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_579518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461865.1">
        <property type="nucleotide sequence ID" value="XM_025615275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V1F1"/>
    <dbReference type="STRING" id="1450535.A0A317V1F1"/>
    <dbReference type="GeneID" id="37117418"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="266"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="800" mass="90769" checksum="AAD33E544CA0A4B8" modified="2018-10-10" version="1">MAPNNDCTVVKVEINESMPNGITTDPMSEPCSICLDIFHHKRLEIWYNIYDYIQPEIPGLTLEDCKFLFHRCPPPLPEYEVNLCTFCAHLRLECLVETSLYDLHISRSRMPKASLGNKPGGYLKVLLDRVSDTVARKNSCSLCALIAAVFTGRNSVDPSQHAVLEITPYTMSKITFRARDKSGDETYGISLHGNHYSDKIKNPGSMLDCSVSSHIDWPAVTQWITESLDGVKKKPQSYELNKPPDEFRVIDVQELRVVLAPTPCEYMCLSYVWGRTTSFHATSRNISRLERPNSLANPHLPRTIRDAIKACALLGGKYLWVDRLCILQDDDSPSKKVQIDAMGDIYKGTLLTLVALEGTDSDYGLHGVSPDLERTINYRLQIGGKEFFKYPTSLYQSCDNSTWDTRGWTFQERILSPRLLFFTANSIYYESDTQNEIYDPIYDQAGSSYEEMVSEIQYRNFGIEEDIVNGFAGALEEFVGKGNHRFSMSLVHFDEAITWNRTGSSPAVLCATRGSTVFPSWSWVSIRGFVWFVDGLNAVPVASWAVIDGMASEFRWLKAGDENHLHEDAIAVGTLLWSHDCLRTPIPLDLKTSSGYDVYLELFRQKFPTQGVFNAASGVWPGGQQGFPDLRERFTQQQIEAGRQSLSILAHSQTIVLALIPPRRRDDKWGLHYQGQDVGTMAFDLRAKHDEALRHTNLDNEPQKMEFLALSVSWVFAEPEENYWYKNPVDELDDTGNFKATNLGYYLEKDKRSRLEDFSMSVMAIETTDDGISRRLGFGRISFIKWLTILNPTFKSIVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V221</accession>
    <name>A0A317V221_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_478543</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462088.1">
        <property type="nucleotide sequence ID" value="XM_025608692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V221"/>
    <dbReference type="STRING" id="1450535.A0A317V221"/>
    <dbReference type="GeneID" id="37110835"/>
    <dbReference type="OrthoDB" id="4505882at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY68066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="76" mass="9000" checksum="6FFACC9A9CC31698" modified="2018-10-10" version="1" fragment="single">VLDEEEETYHINYFQGYRQFQKVGLPYKLFAEMEKAILQHPELAVIQARIKQLDIKIDAGTINFKKNKYKKVLISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6E8</accession>
    <name>A0A317V6E8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_477671</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462433.1">
        <property type="nucleotide sequence ID" value="XM_025608653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6E8"/>
    <dbReference type="STRING" id="1450535.A0A317V6E8"/>
    <dbReference type="GeneID" id="37110796"/>
    <dbReference type="OrthoDB" id="2431938at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY69605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="440" mass="49126" checksum="408CF12ACF3DDF18" modified="2018-10-10" version="1">MEKTFKVIIIGGGPVGLTAAHALHHAGIDFIVLEGRSAIVEDKGASLVVYPHTFRVMHQFDLLEALLSVGGELNHHLSFTSDGHVFNEGARYERIRENHGHGPVVLHRAEVIEILYKGLPATTKSNILTNKKLVDIVSHKNGVDVICADGSTYHGSILIGADGVHSKTRNLMRDIALDEDPSRAWDPVQPFTSSYQLLYGAFPAPSSSGQGYDVQAKGKAIMYLSGPKRAWFFLYKKLPRPTTERRQYSEDDIETLAQEFAGFPLTQTVKVKDVWPHMLGAGMTNLEEGIAQHWYLGRIVLVGDACHKMTTHLGHGFNNGVQDIIVLCNELRRAVQMPPSKNPDISTLTEVFEAYEKTRKSRACSLVADVANAGLETRMHAWENICYYGLSRYLSTPRCVESVAVNWLISPELRKGRVLEYIPMEEVMRGRMSWVYPMNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V794</accession>
    <name>A0A317V794_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_551187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY68010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462059.1">
        <property type="nucleotide sequence ID" value="XM_025613533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V794"/>
    <dbReference type="GeneID" id="37115676"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY68010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="282" mass="32649" checksum="2864E47A78BB06F6" modified="2018-10-10" version="1">MADFTWTEDITGRKLCAKVAEVLDRASVPNVLWNEYMLCAHGLDKDIEIYTVVDRDTGRTEAASVEQELNVSFIIPDDQIEDAYIELLKAKFDRCADNEDECELFRKYFLKPARHFHLCDRDKYGDPLSLNLYRQSDLLWWMPPIPLARPAEGDKYFTVTGDDWIRLETKSETYPVNMSSQTQLPDSHYQIKILTLDKVVEALMLLECVYYQIDHSGCSDCWLDWLKELKTMVSKKDIKIGPMKEYFQPIWDKADEHGISDMLKELGKKLEDKGGCPGAVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7C6</accession>
    <name>A0A317V7C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Di-copper centre-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_590542</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462273.1">
        <property type="nucleotide sequence ID" value="XM_025616038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7C6"/>
    <dbReference type="STRING" id="1450535.A0A317V7C6"/>
    <dbReference type="GeneID" id="37118181"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016411583" evidence="3">
        <location>
            <begin position="22"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY68958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="367" mass="40701" checksum="F4FF6E402D3CF2E9" modified="2018-10-10" version="1">MAPSLIQCALLGLAASLVVETSPVSTSGRQLTHTPAIRNTCEHINYRKSWNALSDAEKHDYIKAELCLMSHPPITGLVENATNVWDEFANVHITQGNDIHYVGQFLPWHRYYVRTHELALQNLCNYTGAHPYWDELTDLSNGNISSSPIFDPVTGFGGNGTGSNSCVGDGTFKDIVLYMSNHHQRGNEFCLSRDLSQSSFSTEAASNVETCFGYANYTDAWQCYNGNPHSGGHGGVGGLMLDPIDSCNDPLFFMHHAYLDKLWWEWQMADLPHRLYDMGGNNTAPQYILDEAGLSQPGADILNYDGDPGSTTTLNHNLWMNWIVANATVGDVMRLNGSVICAEYVVDERARVYNTSVRTDGHYTSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8W0</accession>
    <name>A0A317V8W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CoA-transferase family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462163.1">
        <property type="nucleotide sequence ID" value="XM_025612857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8W0"/>
    <dbReference type="STRING" id="1450535.A0A317V8W0"/>
    <dbReference type="GeneID" id="37115000"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="576" mass="63551" checksum="F5CB1E9A4E2A3C2E" modified="2018-10-10" version="1">MTATHETVPGTEVYGPGTFIDKNVLPVPTDARRVFEVLASRTPGFTKNKAAWDTVHFEGRPEPMVQGPIKSPVMAAALHAMAGLVANELLELRDGKTITENSVTIDTDHAGIWLGSVFTTYINGSDVTALARSRSLGTLFKQDFDQGFGKGISSRATAIYQTKNPHVWYQLHGSLDANTALGSMGINPDVAFNTPQEYYDYIQQHVSKWTPDELEMHNIRHGLCGSICYSPEGWRKTEFGRRLSKHPLINVTAETYARPTPPVPLIKSLSDKRPLAGVKVLEMVRIIAGPQIGVTLASYGADVIRVNCSRLADLNALQLTLNAGKRTVDFDITKTEDMERLKELLADVDVFIQGFRMGSLDRKGLGLHDMLEMAARRNKGIVYVDENCYGPDGPFAERPGWQQIGDAASGSSYVMGRSQGYKDGKSVLPPLPVSDMITGLVGAVGAMIAIRRRAVEGGSYHVHSSLVAADTIALEKEIGLYPPEVVQDTIKRCGFKEITPDQYVTEILFSVIDGWKKGLPHYLDENSRFMTTFEEGHWGRQSLLKPVPRLGVEESTPRWTSPPVPHCHHDRDISWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VAC7</accession>
    <name>A0A317VAC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-galactosidase</fullName>
            <ecNumber evidence="11">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_269026</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462600.1">
        <property type="nucleotide sequence ID" value="XM_025606544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VAC7"/>
    <dbReference type="STRING" id="1450535.A0A317VAC7"/>
    <dbReference type="GeneID" id="37108687"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016416173" description="Alpha-galactosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="13">
        <location>
            <begin position="395"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY70309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="472" mass="52211" checksum="47F5BD314A3BDC68" modified="2018-10-10" version="1">MRSNNMWQLLISFLLLSRAAALVRPDDVGRVPALGWNSWNAYNCEIDADKILTAANEVVNLGLKSLGYEYINIDDCWSVKSGRDPTTKRIIPDPDKFPNGISGVADQVHALGLKLGIYSSAGLTTCAGYPASLGYEEIDAQSFAEWGVDCMPQPSNHHSPTTNHPSDLKYDNCGVPTNLTDQYTYCVPDSTDGSSFPNGTCDDLTNAAPDNYNWATSTTAKRYMRMRNALLNVNRTILYSLCDWGQADVNDWGNATGNSWRMSGDITPSWTRIAEIANENSFLMNYADFWGYPDPDMLEVGNGNLTLAENRAHFALWAVMKSPLIIGTPVLPPPSNPTPSSNQPNKMQLSSIDKSHLTILSNAPLLTFHQDPQIGRPAYPYKWGYNADWTFDPSHPAEYWSGPSSSTALNGTLVLMLNSQDTVQTRTAYWKEVPELKGGYRRGGGYRVTDAWTGNDLGCVRDKYSTRLGHMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VB56</accession>
    <name>A0A317VB56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exo-1,3-beta-D-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_628296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462598.1">
        <property type="nucleotide sequence ID" value="XM_025617475.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VB56"/>
    <dbReference type="GeneID" id="37119618"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016419119" evidence="5">
        <location>
            <begin position="23"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="6">
        <location>
            <begin position="186"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="6">
        <location>
            <begin position="539"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY70307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1312" mass="143318" checksum="E2A3DBBA5D90D5F5" modified="2018-10-10" version="1">MAASNRLPLLFFLFYLISFIAASPEAEPLYLWHQRRAIADPPTPSLHNVSSSALAYAQKLVASAVAQQSEYNAYRVANPKRNTYRSRHSEEAQSTQHKRSDEPVAPTLDANLRAAAALLAEHHASQQLSNGTLHKSYSQFAKTAKPLTVSKRDSSSGYWPSQVDHGLPPMGWDSSYPVYRDVTDSKFGAKGDGVTDDTDAINAAIAYGGSCMENCESSSTKGSFIYFPPGTYLISSPINASYYSQLVGDANDMPIIKTSPSFIGLGAIQSDVYIPNDNGDEWYIEQNNFYRQVRNIIIDIEETTTAYAAGLHWQVAQATSLTNLFITASSAKGTTQMGMYTENGSGGFMSGCTITGGEYGIYGGNQQYTVRDFTIAGQTNASICLIWDWGWTWAGLHLSSSPVGISLINPQDTTGQQAGSTYILDTMFDETPIAIQANFEEKSILETSIITLDNVGVNGVDTMVSFTDGSSLDLPNGDVDFVVIGNLQEKSSKSFGSYSVNVQTPPGPLLDAANDNPIYRDSYFYRNRPQYETLSTGDIISVKDHGAAGDGSTDDTDAIVSALALATADNLIYFPPGSYIITKTVVIPKHARITGMVWSQLVASGDYFSDMTSPKPMIQVGNAGDVGQVEISDILFTSIGELPGLVLVEWNIQAELQGYAGMWDAHFRVGGAYGSKLQVAECPTSDSIESGCVAASMMMHMTPDSNGYFENMWLWVADHDIDDADNTQISVAVGRGLLVESTSGPTWMYGTASEHSILYQYNFYNATNTFAGLIQTESPYYQFADATQSPGPFNASVGLFTNDPTFPDSTCKASDDLCNFAYAVTMYENTNLTIAGAGLYSWYDNYLETCVDTQNCQQRLVLDSGENSGLYIWNLITIGSVEMISNVEDNNIILAKNNTQAIAHPYWSALAGYLDDYKQEILSCTDDSTDAACQTTWNCDLTQSYATIDDLNNALGSYPDQCMPYYAMDTLYLTLEASLDNYTTANTNYDKYFKYYQQYVREMVPEAISTFMADSTTSKPEGGPGNKYFDCTCEGYGPTSTQQCPFRYTQLMGADRFTMTYTLKDSEGFYSELESTYGINRTWVEFVNKGGPVHQIGHCIPGECSSGTDYRWIGVPQAVKGNKIDVSNPKDVITAALPSVNSMQNNLLGRVMDINLGNWTGGMQDLYETFSTPVFMIQQSIASMGQVKAIGEKQAKEDKIKLVLEILGIAFAFIPFLDDLTPELEVLDTAFETVAAAGNVALGIQSIISDPTSAPMALLDMIGGGELKTEDDFAKAAKARRALTENDLESIGKDFKAEEDKFDDTTEPKCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBV3</accession>
    <name>A0A317VBV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_560282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463070.1">
        <property type="nucleotide sequence ID" value="XM_025614140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBV3"/>
    <dbReference type="STRING" id="1450535.A0A317VBV3"/>
    <dbReference type="GeneID" id="37116283"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="862"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="969"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1111"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="969"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="998"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY71834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1270" mass="139880" checksum="036C9CE601E7D07D" modified="2018-10-10" version="1">MQRPPAELRIPAAPTFPLSSPITEEVPSPAPSSPEDHDMERNRPFAFLNKATRKNPFIHKAAHDQHVQEQEAVDGTQNSYQAKPLGLYTGKRSNRPPGLNLVTDFSPSSPKGLQDTSVPTVMDLNDLKALSKAREQERATHSIRGILKKDSNQDVDQPPDRPSNLEKKRLSYLNFRGRRKAKDDLSPSDRPIMIGLSMPFDGSPSSHENQLKVNTGDAQRATLTPSIIVTPAKEDTFWPDIGIMHPRPRVASSIYSQPTPYPDDNDRDLEIPPVPAIPDFPFLRGAGNTGNEPAQRRSIITTGRQRAFSTGTVFEEDDMRRASRSRSYSSGTVKKIPDRLSINTETNRHQSEGWWTYLLSPLLGRFSAVMGNTTPTEAARPPVPSIRTHLTASSDEWWEKEVSCFSPDTPEATEAHHKDELSDWSDDSVNPFDEKDLDNQDRTVETRDQDAFSFMFPGQPIQGSAAEYYQACAHELFSGRPYFECVNHICSLTPKDKIPGYAENAVSTISHQRGLLIDVEDTPRDENRSSKVATAEPQTLYEPSVIDKRSEISLNDLKDNDTPGNNLSGHPPTEYQLSQHPPKSEHPPSDPIAHPPIAYTPSEHPPSVHPASVHPPSVHPPSSPSELPPNDPIPNEQTREIPQEAAPVSHVHGETEGLAPPADNQSERKISWPIFQPVIQPAPQPAIQPVIQPAPQPVIQHVIQPAPPSQHIYAHPATVPSPILIAPPNRALPQHFMFPTHDHEAQPQPPNPTSPGLQQATERGESIPLSDMHTSPAPAYTSSHHSSSALLPRMEPHPTTREEVTNTTIEREIIEIRRKPLEKKEDRKDKKSKKIFAFCCCCCCCGRGQSKKDKNGKVKRRWYLAIMTSFLIIIAIILLLVMTLKKKGDSTPVQSQWLNLTGYPPMPTGIATIAGPEPQTQVSGCIAPSTLWSCALPPEEQSANAPYAANEPNFRVEILFRNGTYPNSTTIASKSSKTLSSRSSDNPYSPSPSPPSLKDQTFLGNTTDNNTVPYAGEETPFYMTILSASHLTSTSTLRLARRSDSSFPNLATIIPSPDENSDGTAAAANLYPQPSSQPVRLYNRGLSTEHYGFYTYFDRSIFLSSLAPVNGSTTDDDPNDKDGGSNESDARVRCTWSQTRFLVQIWTRSNDALLKNSTNASSTTTTSAATATATANSSATYWTRPGSFPYPVTITLDRHGGNAKEKMVYCYGMESNEKINSSDVKLQIENRSYGGQLVNPAPGIFDLYSNSSSDATGEWGGVDDSLTKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDG2</accession>
    <name>A0A317VDG2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_261955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462803.1">
        <property type="nucleotide sequence ID" value="XM_025606498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDG2"/>
    <dbReference type="GeneID" id="37108641"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY71048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="74" mass="8203" checksum="881E46DEFB7E4E02" modified="2018-10-10" version="1" fragment="single">AADTERKPERNGQIGITWRYELRRKLPTARDATWKKSVACCLMVVGGTILGRPSPPVLLPASSLDPIHTHLLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VH37</accession>
    <name>A0A317VH37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TAM domain methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_253034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463165.1">
        <property type="nucleotide sequence ID" value="XM_025606445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VH37"/>
    <dbReference type="STRING" id="1450535.A0A317VH37"/>
    <dbReference type="GeneID" id="37108588"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY72212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="328" mass="37458" checksum="773383B930FA54A1" modified="2018-10-10" version="1">MPQPDGGEHIQVDTSDEDSLLDSESLIGSNLTTISSVRDYCYENGRRYHAYRYGQYPIPNDEEEQDRLALMHHAFKLLLGGDLFRAPIHQPRRILDVGTGTGIWALEMAEEFPNAEIMGTDLSPIQPNWAPPNCTFTVDDAESDWAYTKEESFDYIHARSMGGSIADWERLLRQAYDHVKPGGWVEIQESETWIRSDDGTCKDAVMIRALQQKLDEGSIKFGKRMNIAPEVRGYMQRAGFQNVTDDIYKCPVGTWPKSPRLKEIGRVGKLTLYDSIEPYALAIFTRVLGYTYEEAQEFVQKVQAELVSSNYHVYVLFHYVYGQRPLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKK0</accession>
    <name>A0A317VKK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
            <ecNumber evidence="9">1.13.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilate oxygenase</fullName>
            <shortName evidence="9">3-HAO</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">3-hydroxyanthranilic acid dioxygenase</fullName>
            <shortName evidence="9">HAD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Biosynthesis of nicotinic acid protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">BNA1</name>
        <name evidence="10" type="ORF">BO94DRAFT_539136</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:17953"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:36559"/>
            <dbReference type="ChEBI" id="CHEBI:77612"/>
            <dbReference type="EC" id="1.13.11.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the 3-HAO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.6" evidence="9"/>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKK0"/>
    <dbReference type="STRING" id="1450535.A0A317VKK0"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00330"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043420">
        <property type="term" value="P:anthranilate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006569">
        <property type="term" value="P:L-tryptophan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019805">
        <property type="term" value="P:quinolinate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000093">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>O2</name>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY72460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21512" checksum="12CC8DDB6CEDF67E" modified="2018-10-10" version="1">MLPPALNIPKWLEANSHLLQPPVNNYCVYHPSSPATSGYTVMIVGGPNARTDYHINPTPEFFYQYRGSMLLRTVDTSVTPPVFQDIPIHEGSLFLLPGNTPHCPVRFKDTVGVVMEQPRPQDAVDAMRWYCKSCGEIVWEKRFVCTDLGTQVKEVVEEFGADEEKRTCKACGTVAQSKYAEGELVQPPRVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKP5</accession>
    <name>A0A317VKP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_475818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463274.1">
        <property type="nucleotide sequence ID" value="XM_025608578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKP5"/>
    <dbReference type="STRING" id="1450535.A0A317VKP5"/>
    <dbReference type="GeneID" id="37110721"/>
    <dbReference type="OrthoDB" id="432536at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053275">
        <property type="entry name" value="Agnestin_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38688:SF1">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38688">
        <property type="entry name" value="PYR_REDOX_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="391" mass="43181" checksum="99D7FBDB1B533349" modified="2018-10-10" version="1">MTQPHKCAAVVVGAGPAGLAVMGNLLEKQLGGKIAWVDPFFQGGRINRKYREVPSNTKVSFFQAYATAVQPFRTVINNTRIPSPFSTMAKLDQDKTCHLHHAIDVVRALTDGINKMDRVLPCRGVVTAANLAEKTATWTVRIRFQDSQDEVEVLTSRLVFCTGSSPTEAPISVPGHDIERLDLDVVLKPSDLVSYLPQDTPLTVAVVGASHSAILALLNLIDLARSSHPELRIKWFTRHPLRYAEFMDGWILRDNTGLKGSVADFARQQLEDDKLPHSEAGRFITKVDCGRGQEQAQFEQHLPSCSHVVQAIGFTRDPLPELSVNGFSLEPEFDSVSGGFRDGNGRVVRGLYGAGIAFPERVVDPYGNVEHAVGFYKFMNFLKRVCPQWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKY0</accession>
    <name>A0A317VKY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_474794</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463748.1">
        <property type="nucleotide sequence ID" value="XM_025608527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKY0"/>
    <dbReference type="GeneID" id="37110670"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY74555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="118" mass="13398" checksum="2BC3312C4CB2AC74" modified="2018-10-10" version="1" fragment="single">LREARCTVLTAENGHPALDYRSGPYQRPHRTLMTRTELTVQVLMPIMSEPEVTHILRIQPPFTTDAKFRNTPVIGLLACGGIGTISEAQRLGFNDFIPSPLKLDLRRSHLRFWTSRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNE9</accession>
    <name>A0A317VNE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_589275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463800.1">
        <property type="nucleotide sequence ID" value="XM_025615941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNE9"/>
    <dbReference type="GeneID" id="37118084"/>
    <dbReference type="OrthoDB" id="3434980at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY74607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="64" mass="7342" checksum="70B7ACA5A2B50CDC" modified="2018-10-10" version="1">MSERKIIYYTFDSPESWQNHNKKVTEIIQGDTNIDNWICNRALPPACHPPLTPDNSGNRKVEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNU0</accession>
    <name>A0A317VNU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_207780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464031.1">
        <property type="nucleotide sequence ID" value="XM_025606130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNU0"/>
    <dbReference type="GeneID" id="37108273"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY76034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="162" mass="17829" checksum="36E94F792C854ACC" modified="2018-10-10" version="1">MANEQAPTARWTLLARGLFVDGASQCCCCVLLMGSTIQARLWHAIQPARPLRKPAPLRRQPLVQSRPFKRAPCGLVWFLGLLGRMAAFRFLLLLVVPDATMGGVCVGGSGRLHSTSNRKIEKKKENSNACDFATDSSRRPVQSRQRDKNSSIALEPAELSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNV2</accession>
    <name>A0A317VNV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTPase-activating protein arf</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_524445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463741.1">
        <property type="nucleotide sequence ID" value="XM_025610266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNV2"/>
    <dbReference type="STRING" id="1450535.A0A317VNV2"/>
    <dbReference type="GeneID" id="37112409"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="363"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="200"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY74548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="477" mass="50972" checksum="A84807B7AC2F7CEF" modified="2018-10-10" version="1">MSASKAESQKIFEKLKLKPANKICFDCGSKNPTWSSVPFGIYLCLDCSAHHRNLGVHISFVRSTNLDQWQWEQLRTMKVGGNESATKYFQSHGGSAALASKDPKVKYTCNAAVKYKEELKRRAAQDAQQYPEEVVITDIPAGTPSNGSSTPAGEDDDFFSSWDKPSIKRPSNPPSRTGTPPVVSRTSSPFLNSGANGSRSKSPLSASDKDSASPAPTAIRSSAAVRKTASTTTAKKGSVLGAKKAPKLGAKKIVAAESIDFEEAERKAREEAERIEKLGYDPEAEKAEADAKAKATSTAATAIASPTPISPSKNTQERSSGDVERLGMGLGRLGFGQTVGAAKPPAPKKLGFGAVPSRSVADDEELKQAKSRFGSQKGISSDEFFGRERFDPAAQAEAKDRLRQFDGATAISSNSYFGRPEDELPAADDTYGDLENAAKDFVRRFGITAGDDLENLTQLVGEGATKLQGAIRSYLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPR1</accession>
    <name>A0A317VPR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphoglucomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_589384</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463602.1">
        <property type="nucleotide sequence ID" value="XM_025615946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPR1"/>
    <dbReference type="STRING" id="1450535.A0A317VPR1"/>
    <dbReference type="GeneID" id="37118089"/>
    <dbReference type="OrthoDB" id="8300170at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008973">
        <property type="term" value="F:phosphopentomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05799">
        <property type="entry name" value="PGM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000035">
        <property type="entry name" value="Pgm3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745:SF1">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45745">
        <property type="entry name" value="PHOSPHOMANNOMUTASE 45A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="50"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="13">
        <location>
            <begin position="217"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="330"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY73850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="600" mass="66996" checksum="66A765BCAE5CC217" modified="2018-10-10" version="1">MAANPGEDSLSPLIQKWLEWDQDPTTRGEIERLRDAGELPELQLRLQKRIQFGTAGLRGRMAAGFSCMNSLTVIQASQGLAMYLKNHHADIASYGVVIGHDARYNSAKFAALAANAFISQKIPVWFYSEPSVTPTVPFGVTQLHAAAGIMVTASHNPAQDNGYKVYFKNGAQINSPMDAEIARSIEENQVPWPNAWKDLQPSEYLRAKSYDNLLPHYNTAVWQYATYTVREWKQPQPFVYTPLHGVGGLVFPSLCRSVGINDFTVVAEQEKPDPDFPTVAFPNPEEAGALDLAMQTADREGKDLIIAHDPDADRFAAAEKVNGSWFNFTGNHLGVLLASHLFDSLETIDSDTRIAVLNSAVSTCMLEKMAKAKGMHYEEALTGFKWMGNIARRLEELGYYVPFAFEEALGYMFPEVCYDKDGISAAMVFLLAEAKWKAQGLTPYMKLQQLFKEHGHHETLNTYVRSSSIDLTMSLFRKIRSGPFSAGKSFGAFKILRWRDLTEGYDSGTDDHRPTLPIDKSSQMLTLWLDRGVRFTIRGSGTEPKVKIYIESSGSSRDQAVEAVRDTFLTVLKEWVEPFAPSMTYSKQQITSSGTIFQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPV3</accession>
    <name>A0A317VPV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_538938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463642.1">
        <property type="nucleotide sequence ID" value="XM_025612589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPV3"/>
    <dbReference type="STRING" id="1450535.A0A317VPV3"/>
    <dbReference type="GeneID" id="37114732"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="14"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY73890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="579" mass="64428" checksum="D81E970B829BC95D" modified="2018-10-10" version="1">MADFYDYIICGGGTSGCVVAGRLAENPHVRILVVEAGQHHKDLENVHMVAGWNNLFDDKTDWNIVTSPMSGVNNRQVKLSRGKFLGGCSGCNGTLCIRGSKQDYDDWGLEGWSGEEFFKYMQKAETFHSKPWFKSADRFHGQSGPLHVEPHDLAPISELIMDSFVSQGLPLDHDMFTTGETPHGCGHVPRTVYNGLRTTSGDFVTNGYHRSNITIMTDTTVDRILFKRTPNGLKADGVVVVTANGQQSLFAKREVVISSGAYCSPTILMRSGLGPKEELRRNGIECLIDLPGVGQNLLDHLIVFMFYETEKPGLTNDHLVYHDGNFDKTYALWKDKKEGFLSTFPFGSFAFARLDDRLKDEPLWKNAPRKPGRDPMGLTPKQPNVEFFTTECYGGPKQFDQFPIDRKHAFSIIAELFSPKSRGSVTLKSKNPLENPVVDCNYFADPLDLLVMTEACRFANEIITKGAGTKDIVKGSWPPHLMHHTYTKREEWVHYVKEHATTCYHAAGTCAMGSDGDPRAVLDNKLRVRGVIGLRVADCSVMPTLHGGHTQMPAYGIGEKCADLIKETWSSQVMNVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQL9</accession>
    <name>A0A317VQL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_627325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463964.1">
        <property type="nucleotide sequence ID" value="XM_025617412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQL9"/>
    <dbReference type="STRING" id="1450535.A0A317VQL9"/>
    <dbReference type="GeneID" id="37119555"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF57">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="74"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY75337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="535" mass="60269" checksum="61F2ACE473FA4959" modified="2018-10-10" version="1">MDHRGEQPPALVRRYDVERSCIRCHERKLRCDKATPCSMCLRAKVPCCYPGPERVKRRSKRLSAKPRPRLQMLERDVAGINGPSEVDRDATDLNKSERQPVEEAEGPRLSNGLLVKEGSSARYINESLLSRVLENECDLQSAIDIPDNPTDSDQTQADDGFDGLFSNPLLGKEASGLHPSRGQAAQLWQVYLNNVDVLLKILHIPATEPVFFAAISNPKQTRADQKALLFAIYYAAVTSLSSSATHVILSEDRHSVLSRYQRGLEVSLHMASFLDSPTIPSLQTMAIYLSIGLHRDGRHFHLSPFDCEIRRRLWWATQGYDTRVAEDHGFSLPDPGPSSDTELPLNIDDHQLYPNMKEPPTPRACWTETTMFLITIEMNRAMRQASQLSNPPTSRKSHLETLLSTLQTRLHTQYLQHCNPHIPIQKCALLLGRICLGRLEVFLHHQDSTTTATTPTDKTLSLAIETITLADELKTSDLLTSYHWLFSTFPQYHLLTYVLWHLCICPQTPCAEQAWTVVTVGMATEAIQRGFSGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQR3</accession>
    <name>A0A317VQR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Extracellular invertase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_538556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463859.1">
        <property type="nucleotide sequence ID" value="XM_025612517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQR3"/>
    <dbReference type="STRING" id="1450535.A0A317VQR3"/>
    <dbReference type="GeneID" id="37114660"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18621">
        <property type="entry name" value="GH32_XdINV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF3">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 32 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="87"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="467"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY75232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="627" mass="68530" checksum="A16DCA1C947E41AB" modified="2018-10-10" version="1">MKLPPAAVLLSTHSAMQSRSSVLIDYNVAPPNLSTLPNGSLFDTWRPRAHVLPPTGQVGDPCMHYTDPATGLFHIGFLHDSEGISGATTDDLATYHDLNPNGSQSIVPGGINDPLAVFDGSVIPAGINGLPTLLYTSVSYLPIHWSIPYTRGSETQSLAVSSDGGRNFTKLAQGPVIPGPPFAYNVTAFRDPYVFQNPTLDSFLHSPNNTWYTVISGGLHNKGPAQFLYRQYDPDFQYWEYLGPWWHESTNSTWGSGIWAGRWGFNFETGNIFTLDTEGYNPEGQFFATLGTEGSNQPIIPQLTSIHDMLWVSGNVANNDSNSIAFTPTMAGFLDWGFSSYAAAGKILPSTSKPSSKSGAPDRFISYVWLSGDLFQQAEGFPTNQQNWTGTLLLPRELRVLIIPNVIDNALARESGTSWRVIHTDSNDTVTLQTLGISIARETKSALLSGTSSTEQPRTLSTTGVIPFEHSPSDKYFILSANITFPTSARNSSTLQSGFRILSSEMESTTIYYQFSNESIIVDRSNTSAAARTTSGIDSSNEAGRLRLFDVLGDDGEEGIETLELTIVVDNSVLEVYANGRFALSTWVRSWYANSTGIDFFQSGEGEVRFENVMVSEGLFDAWPDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VS57</accession>
    <name>A0A317VS57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Nucleotide excision repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_191786</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464350.1">
        <property type="nucleotide sequence ID" value="XM_025606039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VS57"/>
    <dbReference type="STRING" id="1450535.A0A317VS57"/>
    <dbReference type="GeneID" id="37108182"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16567">
        <property type="entry name" value="RING-HC_RAD16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="60"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="401"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="485"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY77163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="76051" checksum="C9588B720A5A760E" modified="2018-10-10" version="1">MSLRAIRERRKLEKQHPYITKMWDDLRDSPPIEPVMAEQPPGISRTLKSFQLEGLNWMMRQEKSQYKGGLLGDEMGMGKTIQAVSLLMSDYPVGKPSLVIVPPVALMQWQSEIKEYTNGQLDVLIYHNSNPKVKTLSKDELQAYDVIMISYSGLESIHRKEWKGWNRHDGIVKEDSIIHSIHYHRLILDEAHSIKQRTTSVARACFALNANYKWCLSGTPVQNRIGEFFSLLRFLQVRPFACYFCKQCQCQQLHWSQDAEKRCTECRHSGFSHVSVFNQEILNPITERDNAYARKEALAKLRLITDRIMLRRVKRDHTASMELPPKRVVLHNEFFGEIERDFSRSIMTNSARQFDTYVSRGVMLNNYANIFGLIMQMRQVANHPDLILKKHAQTGQNVLVCSICDEPAEEAIRSRCRHEFCRRCVKDYVRSFDARSTVDCPRCHIPLSIDFEQPDIEQEEEHIKKNSIINRIRMEDWTSSTKIEMLVYELYKLRSKKQTLKSIVFSQFTSMLQLVEWRLRRAGFNTVMLDGTMTPAQRQKSIEYFMNNVNVEVFLVSLKAGGVALNLTEASRVFIVDPWWNPAAEWQSADRCHRIGQRRPCVITRLCIEDSVESRIVLLQEKKANMINGTINKDQGEALEKLTPEDMQFLFRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VST1</accession>
    <name>A0A317VST1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arginine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_588944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464084.1">
        <property type="nucleotide sequence ID" value="XM_025615916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VST1"/>
    <dbReference type="STRING" id="1450535.A0A317VST1"/>
    <dbReference type="GeneID" id="37118059"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000070">
        <property type="entry name" value="Amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF37">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="48"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY76087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="545" mass="59668" checksum="BB09CC39B9B18E86" modified="2018-10-10" version="1">MADPSPVAAYETSSHDAEKKGEPETGWASVDVDYGAETDLKRSLSTRHLTMIALGSSIGMGLWLGSGESLENGGPAAIFIGYLLSGTMIWSVSHSIGEMAVMYPLPSAFTQWTEMFIDRSAAFALGWAYWFSYFITIANELQGIVTVLNFWTDKVPIAAWITIFWVVIIFINVFAVRFFGEVEVIASSIKFGWIFVVIISLIVVSAGGAPKEGPIGFRYWNSMPFTHGFKGFLSVMPTCIFAMSGSENSALVAAETDNPRKAVPRAVSSIWLRLSLFYVLGSLMITITVSPKDPNLFGGSGVNASPFVIAYRNAGLAPLAHIMNAVIFISVLSTGSISAYGGSRTLMGLTHMKMAPKIFGKADKAGRPVAGLVITLVIGGGLAYLNVDNKGSTVFSWFSNLTSLFTLFGWGTICLSHLRMRYAWKVQGRSVEDLPWRSWTYPYGAIWGLFWCILLIIAEFYLSLWPLDGSPTAKGFFANYVSVVAIVVLYVAARCYYRGRWWVDASTIDLDGPRRFYSDAVDEEAKPAKTGVKKYASMVVSAVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VT92</accession>
    <name>A0A317VT92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464055.1">
        <property type="nucleotide sequence ID" value="XM_025612493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VT92"/>
    <dbReference type="STRING" id="1450535.A0A317VT92"/>
    <dbReference type="GeneID" id="37114636"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF22">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE PHMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="350" mass="37138" checksum="6DDE4CAF5D0E5AC8" modified="2018-10-10" version="1">MPPTDPEISALLGPGPPQGLGKIGTMRWAAKNPPKDPQTSLAGKTVLVTGSNTGLGYHAALKFAAMGASRLILAVRTISKGEEAKRRIIEATSGGTSTTITVLPLDMNNFASVRAFPGLLEQANIRTLDIAVLNAGIAPPTYQVNASTGWESALQVNVLATALLAIILMPILMTTTATNGGRPAQLTLTGSFAHLYLTTKDLPTVAPGQKVLEAINSPRAFNVETSYAVMKLLTMYVMQGLVKDYAGSESTPEVTINVACPGLCTTDLGRDFPWYVVLPSKLMQMYCARSAEEGSRALVSATLLGTAGHGKFWSNDVFTEPGIMVTSEEGRRLQAQTWAEIVTVCKSQLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTX1</accession>
    <name>A0A317VTX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO94DRAFT_205414</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464290.1">
        <property type="nucleotide sequence ID" value="XM_025606113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTX1"/>
    <dbReference type="STRING" id="1450535.A0A317VTX1"/>
    <dbReference type="GeneID" id="37108256"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="124"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="187"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="307"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="462"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="382"/>
            <end position="384"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="507"/>
            <end position="511"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PWY76477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="551" mass="59947" checksum="CA557DBE18BC1895" modified="2018-10-10" version="1">MASPAIKKAIAEAASQYAKPEGKVFQYGTAGFRMKADLLNTVVFTVGLLAGLRSRKLSGQWVGVMVTASHNPAEDNGVKLIDPMGEMLEAEWESYATRLANAPLDKVGDVYDELIKEIDVSMENPARVVFARDTRASGSRLVSVINAALTASEVEFLDLKFMTTPQLHYVVRCKNTLGTQYEYGEPTEQGYYEKLAEAFKRVMRGVKVKGSLTVDCANGVGGPKLRELIKYLPSAEEGGLDIKVVNDDVINPDSLNFECGADYVKTKQRAPPSSKAAALDRCASLDGDADRIVYYFMDESNTFRLLDGDRIATLAASFIGDLARSAGIAQKLKIGVVQTAYANGSSTDYIEKVLKLPSVCTNTGVKHLHHAALRFDVGVYFEANGHGTITFSENALKTIKNTEPQSPAQKRSFECLQALTDLINQAVGDAISDMLLVEAILSHKGWSPKEWLATYTDLPSRLVRVEVADRSIFKAYDAERKLESPPGLQAKIESLQSRYNKGRSFARASGTEDAVRVYAEAASRSEADDLATRVANAVREAGSAKDPLPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUI6</accession>
    <name>A0A317VUI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_472618</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464566.1">
        <property type="nucleotide sequence ID" value="XM_025608444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUI6"/>
    <dbReference type="STRING" id="1450535.A0A317VUI6"/>
    <dbReference type="GeneID" id="37110587"/>
    <dbReference type="OrthoDB" id="3362851at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY78054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="779" mass="87394" checksum="1FE29FE648F8D751" modified="2018-10-10" version="1">MFHTFEGFENPGLPSTAARDRSQRQQSVGRRVTTLRACTSCRHRKIKCDGEKPCEACRWYKKADLCQYSDPRPSRRHVEKLSTTLDEFRGVLEKLFPGIAAETLVNLPREKLLELTGKGASQVQTQAPHPASPATSASMEAHTSPASSEDGNLESLQTIPDHISDNRDLKTPEFTGAISDDVNALSLSSKQPSSYLGVSSIHAVLKVIVWLEPGSLCHLSRAPAVGVQRESIMDIASPEVQNWQVYGSQQRHDTPTHTPLQVPESQLLDSYFTYFQPFVPMLDEQSFRQTYLSGRRKDEQWLALVNIVFALGSIAACPAEDLSHKVYYMRCKSYLTLESLGSPHVETIQALGLMGGYYLHYTSQPNLAYSIMGAALRMAAALGLHKEVSDNQYGNSRQKLFSIDQRRRVWWSLFCLDTWGGMTLGRPSMGRLGPTITVKLPHYRETGNVLDILPLLENVRFCKIATQIQEVLAVAPLTKPHEMAHLDSQLLEWYNNLPYILKDHEPCSESIAITRTVMKWRYCNQRMLLYRPTLLSYAMRRVPYIVLRSEERTAIERCREIAEATIQDVATKAQFHQMSGWNAVWLIFQAAMVPLLGLFLNDSTVDDPRATIEACQAQVETTMLVLERLEPWSPAAKSTLEAVSRIFEASKRGSNVVGEAQSVHGGSSATSCEDTTPRMVPGVLPSQVDVSRMMMHEQGYVDPFEPPFIDDSAGQYLWDFLSWSDSNLLQGLVDIDNVNHAALFTQEERGAKFGNNEAAYFGTQMVDSTFFLNSVTPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUQ0</accession>
    <name>A0A317VUQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Allantoate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_538188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464516.1">
        <property type="nucleotide sequence ID" value="XM_025612439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUQ0"/>
    <dbReference type="STRING" id="1450535.A0A317VUQ0"/>
    <dbReference type="GeneID" id="37114582"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY77329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="484" mass="52675" checksum="B3F34B3CC959D8C5" modified="2018-10-10" version="1">MNVPKAMDQAAGYLAQHVAYPPMSSKAEKKLVRKIDCILIPMLLLTATLGAVDKVALSTAAIYGLEEDLHLVGQQYSWAGSILSIGSIVGMSPSSYLVQRLPSAKYLSSCSLGWSCMALLIPACKNWGGLMALRFCMGCLEAIIVPSISLIIAGFYKKAEQPPRNAIVFAAFSSVINGFLSWVVGHIPKSAPLATWQYLYLIVGSISALWCITAFIILPDSPMNAFFLTDQEKYYAIQRLAENKTGIISKEWKWHQALEAAMDPKTWLLFFFNIAINIPNGGLTTFNGIIIKDLGFSAVQTSLLNMPTGIMSTLSAFLFSWLAACWVDRRCLVTMIAACLPIVGSVLVHSLPPTNIGGQVVGIYLLYTYFGPYVVGISIAQANTAGHTKKTVQYSILYLGYAIGNLIGPQTFRASQAPAYTGGFVAMLVSYCVCVALMASYWALVVHLNRRLVGIDPQAGEANGTADAFTDETDFQQTHFRYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVZ8</accession>
    <name>A0A317VVZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_558826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464823.1">
        <property type="nucleotide sequence ID" value="XM_025614029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVZ8"/>
    <dbReference type="STRING" id="1450535.A0A317VVZ8"/>
    <dbReference type="GeneID" id="37116172"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="55"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="258" mass="28421" checksum="18AAACE9A53408BA" modified="2018-10-10" version="1">MCTEYCILHMCWALLPRIPNPPSPSPANQHHTTDQPPSSINPQDHQPPSTLHLGVLLFPGFQSLDVFGPLDCLNILSWDPTTNPTLTLSLISTTLSPVPTRPPHLPTAISQSILPTHTLTTAPPLDVLLIPGGWGTRAPLPEYIEYIRTVYPALKYLLTVCTGARLAARAGVLDGKRATTNKLDWEGVVRQAPNVTWVREARWVVDGKVWSSAGVSAGIDLCLDWVEHIWGVEVAGKVERIVEFRRWREGGRDPFVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWF2</accession>
    <name>A0A317VWF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPR/FUN34 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_473226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464509.1">
        <property type="nucleotide sequence ID" value="XM_025608468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWF2"/>
    <dbReference type="STRING" id="1450535.A0A317VWF2"/>
    <dbReference type="GeneID" id="37110611"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY77322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30740" checksum="D72A9FF8258D3A35" modified="2018-10-10" version="1">MPPSTDSEEKATPAQPTLTNTSTITPNERGFHFDFGPLAHVNTAETTFPAFAGELQPGLWKPPKQRKFANPAPLGLCGFALTTFLLGTINMQTLGITAPNMIVAPAFAYGGLVQLLAGMWEMALGNTFGATALSSYGGFWISLSIVFTPGGFNIQAAYEKADGGSLGMFYDAFGLFLMGWFIFTFLLVLCTLKSTVVFCGLFMVVDIALLLLAIGYLHRNGTDIPNAKAIKAGGLFALLGAFGAWYVALAGIADDSNSFFIVPVFHFPWSEKGRASRRMKSETEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYQ3</accession>
    <name>A0A317VYQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_537935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464654.1">
        <property type="nucleotide sequence ID" value="XM_025612383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYQ3"/>
    <dbReference type="GeneID" id="37114526"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="53" mass="6124" checksum="AAFAC34E545EB1BF" modified="2018-10-10" version="1">MLHTTFNQSQTREVNNEEMWYIAVPGAWSPVPGPVPACRWVRYTFLGQSNKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W0V9</accession>
    <name>A0A317W0V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_537161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mitochondrion-specific ribosomal protein mS38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465143.1">
        <property type="nucleotide sequence ID" value="XM_025612202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W0V9"/>
    <dbReference type="STRING" id="1450535.A0A317W0V9"/>
    <dbReference type="GeneID" id="37114345"/>
    <dbReference type="OrthoDB" id="5364404at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013177">
        <property type="entry name" value="Ribosomal_mS38_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035">
        <property type="entry name" value="AURORA KINASE A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32035:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08213">
        <property type="entry name" value="COX24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01155">
        <property type="entry name" value="DUF1713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein mS38 C-terminal" evidence="6">
        <location>
            <begin position="290"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY80284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="324" mass="35651" checksum="52181892957AEE62" modified="2018-10-10" version="1" fragment="single">MLSSSLRRAAWAPIGPIAGISRASSQSITTSANGLIGSSQHTPAKGVNSAEKREGKASRRRGKDSNGRNGSKQQTAFSRLPSVPSTQHLQPHDVHVASFFSIHRPISVSTTVPPTSTPEAFDAIFTAKKSAKPEVDDVIFTLSSAVNSMENSAQQPGEQEGSLQYFDMEGNQLDGLNLSDLKVSVEELTKRLRPFHPPPPPIPFDEARDAGASEFEDLPRETSSYSAVLTIHESTHADGRKTYEAHTGPFVPADEMEAPGAIGETKAIIDVPRNSGTTYIERLRNNRTMHAISTKRRRRLKMKKHKLKKLRKRTRTLRRKLEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W404</accession>
    <name>A0A317W404_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_521200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465190.1">
        <property type="nucleotide sequence ID" value="XM_025610138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W404"/>
    <dbReference type="STRING" id="1450535.A0A317W404"/>
    <dbReference type="GeneID" id="37112281"/>
    <dbReference type="OrthoDB" id="4060227at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="38"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY80331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="659" mass="73724" checksum="4C8435FBFC90989F" modified="2018-10-10" version="1">MKRSSYDADLESPRPHERRPSLVLDGRPAPPKISKARACAECKRHKIRCEFKKGETSCTKCIRSGIKCVINDFSQKFVDDDVMWKSQASATIQQLQAAVSHLLQHGGLPDLSTYITGDIQSGPSPVASQSERRLSSETSPSDVKPSEPGIVMDVTREPSQEPDLQDRELVPAPMRSLYEVTKLRNLRNNPIEQPKLTLLEEDFISRGLISLHEAEELFAYFSRTMNQLLWGGIVLVHRDLTSVRRASTLLSAAVLTVAALHIPNRTETLNRCYGEYVSLVSSMSLTRAHTLDDIRALCVGAFWLSELSWKLSGHAVRIATELGLHQSYQKMMRGHNDQYERAQLWYLLYVCDHHFSIAYGRPPVIHEDAAIKNYESFLQSPLVVPGDIRLLAQVALFMILTEAYRTFGSDTEQALTEEHFGQLRVYNVAIDQWRLLWQPRSADSPYVRTYPSKGVVLHYHFAKFQLNSLSLRALSPSNTPVFSMDRKESANIAISSAMACLNMVLEEPDIRDAIVGVPIFTHTMVTFSAVFLLKVAVNWNSAYLSLDGRQVRRLVERVIELLNCVSAGERHLTRHIARGLGKMLERFDSWDAWQAGGPSVATSGTVDRPGSSDVPGGANAMAQGFPPPDLIYDMVGTYGFGLDENLLDPSMASFEFLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6B7</accession>
    <name>A0A317W6B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative choline transporter Hnm1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_495967</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465707.1">
        <property type="nucleotide sequence ID" value="XM_025609276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6B7"/>
    <dbReference type="STRING" id="1450535.A0A317W6B7"/>
    <dbReference type="GeneID" id="37111419"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY81639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="509" mass="55545" checksum="DCA3AD14D36262C5" modified="2018-10-10" version="1">MSDIATKEAVIHAKDGSVLDADEQRLAQMEGHTQELTRHFSILSLIGLASTTTISWTGLGLSIVTEINAGGPSAIIYGFILVTLLQSFLGASLAEFVSSYPTEGGMYHWIAAVAPRKWSAFLSFITGWLTVCGWIFTTASTNLIFAEVVQALYALYHPNLVIKTWQTFVIYQILNLLTAAVVLFGNKIIPALNKFSLFYLQIGWLVVLVTVVACAPTYQSSDFVFRTWINNTGWSSNGICFITGLVNPLYSLGGLDGVTHITEEMPNPSRNAPLAIGITITIAFMTGLTYLIALMFSVQDYAALSTTNTGLPLAELFHQVTQSAGGAFGLTFILFVALGPCVVSSQLSTSRVLWAFARDDAMPFSRTWAHVSKRFGIPFNAQLLVAAANAALGCLYLGSSTAFNSMLGAAVTINNVAYLIPISTNMLTGRANMHRGVFYMAKWGWFVNGVTLAWLIFAIVFFSFPYNMPVTVENMNYTCVVVGGLIILILAWWFVGSAKYREKITRAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8D2</accession>
    <name>A0A317W8D2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_146120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465635.1">
        <property type="nucleotide sequence ID" value="XM_025605764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8D2"/>
    <dbReference type="GeneID" id="37107907"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016463161" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="84" mass="9421" checksum="1F21B09C9A3B8C17" modified="2018-10-10" version="1">MASTLVILTTWLCLDFAAQHGKRRGNSSSVFDLMVPPQDNLPFVMVLFHYPSFGFGRNMEVHMAMKTSDSLHPSQIDVSSDETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9C7</accession>
    <name>A0A317W9C7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative 1-aminocyclopropane-1-carboxylate oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_558044</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465676.1">
        <property type="nucleotide sequence ID" value="XM_025613974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9C7"/>
    <dbReference type="STRING" id="1450535.A0A317W9C7"/>
    <dbReference type="GeneID" id="37116117"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="28"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="193"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY81608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="368" mass="41645" checksum="1C3429DFC8CC8E04" modified="2018-10-10" version="1">MATTDTTELSYVQVPETSEDLDWADLRTLDLSKFDKPGGKQELAAELTKAIEDVGFFYVINHDITEEAIDTQFAIAKSCLLLSNEEKSQYRAALEEGDYNGWKPAGTRNLIPGVKDNFEIYNIPKFIPEHADPKHPEVVRRNLAIIERFSKQIHDQIVTKLLVIFAIALGLEEEWLVKRHRYEKTSGDHLRYMKYYARTEEENRKLGGVWLKGHSDMGSLTLLFRQPVAALQVLTKEGTWKYVQPQMNALTVNIADALDFLTNGYLKSSIHRVVAPPKDQAHIDRLGVLYMVRIEDDTDLIPIEESPVLQARGLTGEKVFGSDGKHVKAGEWVKQRVIKNLGNSTGTEGDNDVENVEIVKGVSVKYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBT9</accession>
    <name>A0A317WBT9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_625447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466382.1">
        <property type="nucleotide sequence ID" value="XM_025617286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBT9"/>
    <dbReference type="STRING" id="1450535.A0A317WBT9"/>
    <dbReference type="GeneID" id="37119429"/>
    <dbReference type="OrthoDB" id="5139341at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="233" mass="26218" checksum="BE641AC65ACDD935" modified="2018-10-10" version="1">MTSPIQAPYSELPDSIRIILTLLTILSITIQLYTLWTKKSSKGISLNYTLCLLLVATSHLTKETYMTLNVPESAAGQFTHDPLNTGDWLNFIQVLVTWILFLFLFILSLYFRPDPQPHLHPRTRTRTPYTPTPIYILTLLATLLSSLLPLLLDLLHLTPATLPWPRTDILEAFVAIHAILLTPLASFLGVYAFILQSRQRKDLCADDSALSVVGLMAQSIVFGLVALNKRYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD73</accession>
    <name>A0A317WD73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoporin Nup120/160-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_576369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465937.1">
        <property type="nucleotide sequence ID" value="XM_025615131.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WD73"/>
    <dbReference type="GeneID" id="37117274"/>
    <dbReference type="OrthoDB" id="67716at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048884">
        <property type="entry name" value="Nup120_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21486">
        <property type="entry name" value="NUP120_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="5">
        <location>
            <begin position="77"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup120 helical" evidence="6">
        <location>
            <begin position="642"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="7">
        <location>
            <begin position="872"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="789"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1140"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1194"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1306"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1149"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1194"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1210"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1223"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1316"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY83152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1325" mass="149871" checksum="B4985040C4C76797" modified="2018-10-10" version="1">MAKIYKDTRVDLRPYSPNTVVNIPIPTQANTQSRARFSISTTPSRDEPVAKDEDEFSRRYLATQGSIYFRKRNVYPRTFLWRVVDDSKVLEVQCVDLTKAGIEHHEYNVTLRLEFGEEIVPSGVEFSDLEEHEALSVFVITASKHLHTLTLRPEFFRRTESIDDNISDWCKMCIPAPLTFSHPHRLHASSPLELFISLDNGALLRLTRKSGDDGSHWSPLTFDERTWGASFRGLVKWHAQPSIKFKGRNLELSTANAIATTTDQTYVFAVCLNHTLKIWNLATNKLAATKDLLDREVPESDESSYSLNPSESSFIRVFNMERALDGEYRYYVVTYSPFEDGLFKFWAVKGGLTSPLIVEDLYPGVALKPLDPDSTGSMFWSIADFQIKPAEEGKRMELWVLWRNSSLYQLYTLHFNFETLATDWSSNWVSTVMDSRGQEPPPVIALSDVVDPTEKWLKFLLQPNRLSTEVLETALFIYQEALRPLSSSVVVKRNAPLAERLCSTIAATVSLRKYAEDGMDFTRYRTDTDSKWRQFWQIADDVNKRRFEPVSLAYDVYHETPWMVLSDSCAVIRECSSTELILHNSGPELRSEGPKIVDRWRHRNLDSEIGSLFEQASHLMTVASGFRRNFNAELEVACQGALEAELFTEPSSSVQDRMDAFRERCDFGEQISNKTYDGLVAAINEHLNIFSLQNEVFYTLVDTIPLGFPAKDSDLVNTHFGVKVIVNGVQETISFTHKTLTDLLYLILFVDGEVQQEEDSTFDAADLFVTIITLLREYEMMSWLSSHSRKSSDKPIKATDDPSATPISAKESSARKKGERMATILEDLFASDIKPRQAIGLSQSYTISLGIRDILSWVTRQGEVAYPNALVYIQCDLIAKNNIDLAWDFLRFQASTSWATYVKGRLYVAMSEFDTAALYFRKAAYLLSCGKPLGNLHEMSSTLLDIVSVDCFHNGLPKYFQHILTIFEHARSFSHVADFASLALQALASEHGSEKDAETASLRSDLLSRLFYASLQNCQFDQAYSALARYKDRALQRSALSSLITGILAASGPGTAGLQKILHFPTTLVPNIASHVDDILASLARRQTSFSSYLDTESKWADSTPDYQRILQAYRIARGDYRGAAEVAYRNVQRLRHARDHSSHLVLTKSRETDDTRPTEEDDPESKEIRHELLSLINLLACVDKSESYILVEKDGQQQPSFDRRRSLQPDDDGNVFMDDAEGSTAAAATGSPTPNPYSSHRRLSLSASPTAIRPSSRRDSKSSIPATSIPQRRVIVTLDHLRREFQSELDRVSRIERGDWEFGILDDHHNPAGDPDNDDTMLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDF8</accession>
    <name>A0A317WDF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar import and degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_117770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465863.1">
        <property type="nucleotide sequence ID" value="XM_025605551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDF8"/>
    <dbReference type="STRING" id="1450535.A0A317WDF8"/>
    <dbReference type="GeneID" id="37107694"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="331" mass="36905" checksum="A01D852430CAE975" modified="2018-10-10" version="1">MPTPSDNTPLLTASSIVEEISARSTCPPEVERLSSLRDSRESSTTIAESDAPDSTFSPTVASTQTALTPSDDAIPSSNADPVRGESVTSVPMKGVGIPEEEPAARRLSPAAEPSCSVAPSSSVPSPSATSLLSYEFSNIRLLPNYTSSFLRPGSKFTGTQQSDSHVYSVDVEIKHVDILESYLCGYLRIQGLTEDHPTLTTFFEGEIIGPKHSFITRNEAWGATEKSDMQHWAKFPPWRSHVKQNKRQEFTLWNYAQRDHIFMRWKEYFLVPDHRVRSISGASFEGFYYICFNQVEGTVAGIYFHAKSEKFQQLELRHVQDHGCAPAMEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WET1</accession>
    <name>A0A317WET1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_113565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466205.1">
        <property type="nucleotide sequence ID" value="XM_025605524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WET1"/>
    <dbReference type="GeneID" id="37107667"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="274" mass="30227" checksum="F96C8AA4296064C9" modified="2018-10-10" version="1">MADVRSLLRSELAARKGSSQAGSAGNRVTKKRKVDPADDSMRKRMKPASAPSGQPTAHTVQPPSARAIEEEDEIEGSEQDVAGPQLPSDTAHEQQSAEPTVQPPDTPLVAFEPSAATTEVIDEDEWAAFEREVAAPTRMPHRPAALEAAATISAAPVSAEELAAQQRKESEAIKKSREAEAEGEREDAARFMEDELDEMEQLEERVRRLKHMREELRKLKTVEDADVHKMDESPSAVTPSEDQQNPAAEETNDDEDDDDDDDDYDDDWNTWGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEZ1</accession>
    <name>A0A317WEZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_547448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466265.1">
        <property type="nucleotide sequence ID" value="XM_025613334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEZ1"/>
    <dbReference type="STRING" id="1450535.A0A317WEZ1"/>
    <dbReference type="GeneID" id="37115477"/>
    <dbReference type="OrthoDB" id="4207132at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="29572" checksum="224814180D5B31CB" modified="2018-10-10" version="1">MDSTPEQGPLSGRDINFDFGTWEIGKIISRKYREQEDPQGGSTLECHEVYEASAKDHPSKQAIIKTKKQIADWDDSDYDEPSEEIHREINNLSDLEDCRATPKLLGSVIYTQRPDEELPAGYVAYIVMEKVPGEDLENFDTFTREEQDHALWEFGSYHYTHWDPRRENIVWGPSSGQCFIVDLEDAEKFPSLTKRDTCLDSFAALESWGLIKGLHDGKLFFEKDRLLEDLKARLDSQEPPKMAGELQYTIFRKGEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFV1</accession>
    <name>A0A317WFV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_586560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466506.1">
        <property type="nucleotide sequence ID" value="XM_025615766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFV1"/>
    <dbReference type="STRING" id="1450535.A0A317WFV1"/>
    <dbReference type="GeneID" id="37117909"/>
    <dbReference type="OrthoDB" id="5425782at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016256020" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY84581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="27601" checksum="E1177E3FD741DFB1" modified="2018-10-10" version="1">MRAARLSFLLYSLSLVAVVAGQSAAVTSVGNAVTTPAAAATTEAATTSAESTSSTSSSTSTSTSESSSTTSERQPTTTSSTTSEQTTSTTDAQAHTTQQQQPTSTTNNNAQTTEPTTTNKNGKTTVESTTQQTTATPVVKTVTTIETISGTPVQTTLTTTSTPASADSTGSPGLSGTSSSNSNGSSGLSSSQKKIIIGVVVGVGGAIIVGALAVVGWRIHARKAAQDNDESTDLMSGTAVGAGAREKAPSPGVGGTPFKTTLDQYHNPGPVNAASNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH16</accession>
    <name>A0A317WH16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_101923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466452.1">
        <property type="nucleotide sequence ID" value="XM_025605460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH16"/>
    <dbReference type="STRING" id="1450535.A0A317WH16"/>
    <dbReference type="GeneID" id="37107603"/>
    <dbReference type="OrthoDB" id="5354458at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056687">
        <property type="entry name" value="DUF7785"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057199">
        <property type="entry name" value="DUF7877"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25009">
        <property type="entry name" value="DUF7785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25289">
        <property type="entry name" value="DUF7877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7877" evidence="3">
        <location>
            <begin position="62"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7785" evidence="2">
        <location>
            <begin position="486"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="778"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY84527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="875" mass="94125" checksum="057989480559E5C6" modified="2018-10-10" version="1">MSADEGGGTAPVPATNGEQPQNTPESSVLATPGKRKRVASHDDKVAQDAGASAALSQERAKLQETLRNLVEILSKSDADLHLLSCPLPSSPAKPRSKRAKVSGDKDESSSIQARVASDRYNNLSEFLSDIEKASTAVIERNKAQATAAPADGTPLTETVNRIAAFKKLLNSLVRQAHVSQSNIKTETSEEDGETPAKTTPANVETRNESLALTLFGNPANPKQLYSSLQKTVKVPLPSDDPNADKFVEVQAPLREDGLPNGISITKVQPVDAETATNEHKRTFGDVFAPRPTLPQLEPPRKARTSSRNATNGWIDPFEAITNYKAFLGERNNYCLAHLPSGHWLQYGGVTSAPSTWNRRQKQQPAQQPGEEVPNDDSALSTDEDAALLQGVYSSFAPSFDSSGAVVQADSKDLVWWSKRGARRLNTLLSLPYLEEEQADTTTVQPGSIGELDESTLEEMVKSFNPDDFADNIAHADRSTERQHEDRDLEEVLCDVSELLETLSSYQRIRSLETASSGSQGTDPKETSPEIGGPDIPSLAERSVYETLRSSLAVLIATLPPYAVAKLDGDQLEELNISQKILVENPEYQGTMEKDDYALQQERAVAMATSSGANRTSTPSRSGSYQAQFNQRAFGANNRAQPQPSFQTTQPYYGGRQNSTPTPYTPGHAQPFAGARPPSTPQQRPGYFPGYAQPSPQFNQGITVPQYQRPGQNGYHAYPGQQPGPPPPAAQGSPQPYTPRPGQPAPHNAPYAAGRSASPQKPPPYATPRGSYIPPGSANPQQRYMPQQQPGQQPPPYGNYPSNQAPPPSGGYSNSAAAMTYARSAAEQAIMMERNKAQLAAAQNSTSSTTPQPAGGEASQDRSATPGSKQIGTPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WI14</accession>
    <name>A0A317WI14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_110556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466623.1">
        <property type="nucleotide sequence ID" value="XM_025605502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WI14"/>
    <dbReference type="STRING" id="1450535.A0A317WI14"/>
    <dbReference type="GeneID" id="37107645"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="268"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="457"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="851"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="703"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY84698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="931" mass="101127" checksum="46D054441D67F66D" modified="2018-10-10" version="1">MTDTSPVAITHPTTEPFPVTVPLNSPVVNGAISDSIAPDEEEPYTIKCICAFEDDDGNTVFCEGCETWQHIECYYHGRDVPEVHNCVECEPRPLDGRRATERQRRLREQSDGGDRKAKRSGAKSHKKKSKEHDDQVNGFHHRSESSARDQPLAKKVKTNHRASGSVSSVSGVPNFASDVRKRAAPSMSPTKSSGSSIPLYSQEFLQLYDQDSKDYASMDSNLFVNLPLAADLASWVTEPAALARIANGRSLQDIFTWSGATLDRSRWPTLSIEKITDSNIEVEGRHPTWKLLKTRDHVGKDEIVGEITGKIGLLRDYCLNPDNRWQELRHPEPFVFFHPQLPIYVDSRNEGSVLRYVRRSCRPNVTMKTYITNQVEYHFCFVAKEDIAADSEITAMWYLDPQLFESSNGLVKQESNDNAQDNAAICISNVLAHFGGCACVPSSNCLLASVDRRRHPKVMDANAKQASVKRKKTKPKANISPPAALSRAGSEVTKNQDEEDQADSRSASGSVRGQTRSRDLTPTLQTSTEGFVLGESELSAREKRKIAAAEKKFQQLEQDQQASQRKKKRTSGQSTHGPRDRQSHSPPSGGPVGSLPGMRHVSPRKTSGSHSTPSARSPLGHLHYVDSAMQTEPDSSDGVLSPASPALLSPRRPSFVPLTQRLLKRCYSDRVKLEQSSPSPVSPRTIFIEHQDSSPTSMSPHEAAPLTATTPSASAEHPDIVMKDVDSPVETSPSRSSDMHLDASPLSGRGSIKPPLPPPWPSTAAHNARIPRNVKDNHRNLNLLHLPLPPATTPSHQSATSPGPIAPSVLSSPSTDAASQPHVPTTPVSGVAGPSPVKKKLSLGDYLIRRGTLSTPTSEKTQAPVTAMLPPTPAAPPPASRDGATTGHNSYAHTKAAGGPEMAKPDDRGAQNVTLKGISGVTQTSHIPSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL32</accession>
    <name>A0A317WL32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_624381</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467402.1">
        <property type="nucleotide sequence ID" value="XM_025617213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL32"/>
    <dbReference type="STRING" id="1450535.A0A317WL32"/>
    <dbReference type="GeneID" id="37119356"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF41">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY87194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="533" mass="58175" checksum="25987ED8D0E0D518" modified="2018-10-10" version="1">MDLDSINDQRRIQVNRPGDVEYAPKGLVAPKYMGTVRDQRDMSSLGRIQVLRRNFRFVSILGFGCTLISTWEVILTFLSSGLTDGGTAGLIWGFIIVTAGFALVFASIAEMASMSPTSGGQYHWVSEFAPRRGQNFLSYITGWLCAMGWQCAIVAIAYLAGTIIQGLIVLNNPTYVFERWHGTLLVIAITAFSILFNTFLAKNLPMVEGLILIIHVVGLFAIIIPLWVLAPRNSPKAVFTDFNDGGGWGSAGTATLVGLSTTITSMIGFDCSVHMSEEIKDASETLPKAMMAAVGVNGLLGFIMIITLSFTLGDVNNILSSPTGFPFIQIFYNTTNSYAATNTMTAILVITLTASTITEVATASRQLWSFARDQGLPFSSFFAYVTPGWNIPLNSVLVSLVVTVLLSLINIGSNLALNAIMSLTITSLMSAYVLSIGCVLLKRLRGEVLPARRWSLGRFGMAINIASLAFLLPIFIFSFFPLTKTVTTQSMNWSVVMYVAVVGFASAYYFFRGRYQFVAPVVLVRRDFDLSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL55</accession>
    <name>A0A317WL55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_82470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467032.1">
        <property type="nucleotide sequence ID" value="XM_025617693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL55"/>
    <dbReference type="STRING" id="1450535.A0A317WL55"/>
    <dbReference type="GeneID" id="37119836"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="521" mass="60128" checksum="A956DE605EE99201" modified="2018-10-10" version="1">MPDRVSHHVVIGKAEWGDPQHFHLLLAIHHPSFPSHLLSALCFFFHRILSPHQSDLLLPSSSAALTMPGDDDPIQNRPAAPSAPDSRRWPDDENPFVAFRRFADEQLSSMLQSVMGIPSMSSRPSPDHWAVFDDDARFRKRDNSESKGDDHAAADNSDHPFHHNNRHPSRSWTEWEDQWHVDHPRRRRTDQDFFDSFFDSPFSSRFLHPHHHPMFSGFASNTSTWPLTYLMFSPYSPLHLERQDYYQSHHDRGVFSSLMSSLSLSSDCDPAESHWREAFEDLIRLENGKPMLDHDSSAVVKRETTRDWLYGLVKRGSVGDQWKISELGKNDWSSPMAISQFHFKDDDCETPKDRIVEEKTEALTELDMFDRFFEDAAARESKAFADAFESPILRFLLEERQRSRDTPSDTENWFERVSNNSIPDAVPEKQQPAPETQAIVPSRAEPTAEKPTVISTMTRTERIRLPNGSTQKKTVWTKKFSDGREESNESVEIMNPPQSQDSSNQDRPTSDQKNSGWFWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLN3</accession>
    <name>A0A317WLN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_492772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467511.1">
        <property type="nucleotide sequence ID" value="XM_025609186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLN3"/>
    <dbReference type="STRING" id="1450535.A0A317WLN3"/>
    <dbReference type="GeneID" id="37111329"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="926"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="869"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1119"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="869"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY87303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1183" mass="132947" checksum="5F04E3B2FFD6A464" modified="2018-10-10" version="1">MSASNDIGLHLSPVSLHDESLTEKTSEMNYDATKTDGDAPISAFIEPCTGIDSSTDTPMTPASAPTPATPLSEPTIPKLWVGSFQAVENEKQQNIDICIAVGVLKKPEPSYVTDSATPAEPNSYPAKEVAILESHHWIQTEELGCGDNPSCRGVRVYVLPDDVGRKLIPRSSTKLRRALKIVMAKIDSSVEAWNGKEFLNQKGVSNLASGPEDESLWYIFNTLRDPEPQMERMRNPYARRAMQELLAVTAHGEDESGQYYSGVLGLKTPLYPYQRRSAATMVQREAQPAQMLDPRLQALKSPRGQEYYYDKEEGSIFREKKMYLEACGGILAETMGCGKTLICLAVILATRGHFPEIPLEYQEIKNPVRQVTGSLVEMAAATAGRFSLPWKTHFDTLGHCGTFYDRCVRACEMNRGTYTITPPPARHNGRSSVASTRLPPQQLRLCSGTLIIVPPNLVNHWQNEIVAHTDGLKVLVLRNSSHKTPSPDELLQYDIVLFSKVRFEKEAGEAIDNKRSSIAPEESPLTKLHWLRIIVDEGHNAAGTGHRTNIVHFMKQLCIERRWIVSGTPSNGLYGVEVSLASQETQTSDTDLAEATTAVLRDRKKTGNALNSELKDLDRLRYIVMEFLDLKPWSNSRANDPASWTKYIKPLGEDGRRRKAQSLRATLQSLVVRHRLDVIHNEIPLPRLYNKVVHLEPTFYDKLNLNMFIFGLAVNAITSERKDHDYMFHPRNRKHLSVVINNLRQAGFWWAGSDDISQTIDNALKYLEKHSKTMSEDDTATLREGVRIARMALRCGSWCAFKQMHELGVFVRDFPAHARTMWAIDHSMAHHEPLLLGITQAHHAQKFVTKHLNTYDPAEGLAGAGIKARRELSEREGDNASHKKTTPDKPVKSSSPKKTYSKGLFKTLPAESPLVQTKLVATASAKLTYLLDQVSELHTAEKIIIFYDNNNTAFWIAEGLELLGVDFRIYASTLKPAMRVEYLTLFRESEEVRVLLMDLRQASHGLHIANASRVFIVNPIWQPNVESQAIKRAHRIGQTRPVSVETLVLKDTLEDRMLQRRKDMTDSEIQHAERDLLDDSTMSSIIQNEQFIPMPENEDTARIAYLRHPSGLFDRHKLSIADNEEEDKKPEVPVHTTPRKRKRAIPLEPENTDGPDLVTSKRLKSASLGLGFISPQGILMTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLR3</accession>
    <name>A0A317WLR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_535451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467541.1">
        <property type="nucleotide sequence ID" value="XM_025611787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLR3"/>
    <dbReference type="STRING" id="1450535.A0A317WLR3"/>
    <dbReference type="GeneID" id="37113930"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="81"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY87333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="469" mass="52433" checksum="801494BB165634F0" modified="2018-10-10" version="1">MFFGYRAAISSTRAAHLHSSSHAFLRPSSTPALPRHPFSRAMSATTARPDPFRPAARVAGQRQDVWSIVNEAAAASPVQPIVNMGQGFFGYNPPKFALDAAKEALDRVDCNQYSPTKGRPRLKKALADAYSPYFGRTLNPETEVTITTGANEGMLSAFMGFIEPGDEVIIFEPFFDQYISNIEMPGGTIRYVPLHPPKDGATRTSPASEWTIDFEELENTINDKTKMIVLNSPHNPVGKVFSRAELERIGELCVKHNLIILSDEVYDRLFYVPFTRIATLSPELYERTITVGSAGKAFYATGWRVGYLIGPEHLIKYVAGAHTRICYSSVSPLQEAAAVAFEQADKVGFWDESRDEMKKKMERFCEVFDELNIPYSDPEGGYFVLANMSSVKLPEGYPFPPHVASRPRDFKLCWFLIHEVGVAAIPPTEFYTDANAHIAEDYLRFAVCKNDDVLETAKERLRGLKKYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WM86</accession>
    <name>A0A317WM86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_68584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467373.1">
        <property type="nucleotide sequence ID" value="XM_025617599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WM86"/>
    <dbReference type="STRING" id="1450535.A0A317WM86"/>
    <dbReference type="GeneID" id="37119742"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY87165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="237" mass="27500" checksum="67DE038D27ADCB80" modified="2018-10-10" version="1">MTTLVLTSKKKTATERNLKETAAETQRLATDPSLLSSLSRKHAFASHNLLKADTEAAGEDFERKRAWDWTVDESEKWDKRMEKKQRHRDNVAFQDYTQDARKVYKRQLREVQPDLESYEKEKMAAIEKAAANGDLEIVETNDGEMIAVDKNGSFYSTADSVGFTENKPDRAAVDKLVDNLRKAEEVRLKKRRDRRGDDDGDVTYINEKNKQFNQKLGRFYNKYTTEIRDSFERGTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNF1</accession>
    <name>A0A317WNF1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_60771</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467782.1">
        <property type="nucleotide sequence ID" value="XM_025616545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNF1"/>
    <dbReference type="GeneID" id="37118688"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="89" mass="9130" checksum="3D68DD6821A00759" modified="2018-10-10" version="1">MPSHSPADPPPVSPELKGRIKSHSPRDQDALKSTAGPAASGKLVDARDSSKSWGRMVTSTTALGARRFSPPPACPSPLAVSGDDSGPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQB0</accession>
    <name>A0A317WQB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase, PLC-D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_556340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467644.1">
        <property type="nucleotide sequence ID" value="XM_025613859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQB0"/>
    <dbReference type="STRING" id="1450535.A0A317WQB0"/>
    <dbReference type="GeneID" id="37116002"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016340329" evidence="2">
        <location>
            <begin position="18"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="467" mass="53929" checksum="020B968B761E4011" modified="2018-10-10" version="1">MKLNVATISALATVASALPQRRNSETWGQIRSNIKHVVYLMMENHSFDNIAGYWDFHPDIDNLRNISYCNEYTNPNWTVWDEPLNVCAGPFETEVPLTDPDHNFAGTTYEIFRTWYPNKTDVPNMGGFIERQSEKYEASPGEASFVIKAYDEKKTATLIEVAKNFAFWDSYFAEHPGPTNTNRQFATSGSTCGFVDNTYQSAGWYANYTGTTCATSIFESLSNKNITWKNYYETDIVDAYMYKWVQDNAMDRLVHSDQFYRDLEEGTLPQFSYYNPECCTIDSMHPTSNMASGEQLIKHLYDAVRKSKYWDNILIILNFDEHGGFADHVPTPINVPQPEDGITFSGLSDGHNVTYDFTRLGIRVPAFIISPYVPANHLIHDQGTMYANNSEYTHTSILHFLQELWELDGLNNRVQWAKTFEHVFTNEKREDTPEKLTTPTWYGSSWEPKPDPFYKLNQDYDYYENLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQT2</accession>
    <name>A0A317WQT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_73512</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467486.1">
        <property type="nucleotide sequence ID" value="XM_025617630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQT2"/>
    <dbReference type="STRING" id="1450535.A0A317WQT2"/>
    <dbReference type="GeneID" id="37119773"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18983">
        <property type="entry name" value="CBD_MSL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000077">
        <property type="entry name" value="Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038133">
        <property type="entry name" value="HAT_Nua4_EAF3/MRG15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Chromo" evidence="14">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY87278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="330" mass="38391" checksum="EA31F39268FE308B" modified="2018-10-10" version="1">MAPASHMTYQKDEKVLCFHHEILYEAKILDLRHTDPEDRKSPFEYLVHYKGWKNTWDDWVPQDRLRKFTEENRELATTLRREAEAAFRQKSTKASVKKRGGSDRSSARGSEERQTSVPGRGTKRARDNDIEKEESFYVRPSVRIVMPDNLKSLLVDDWENVTKNQQVVALPAKSPVNQILDDYVREEKEKRTSSADMDVLDEVVMGVREYFDKALDKVLLYRFEREQYRALRRKWEAGSGDYADKGSVDIYGAEHLTRLFATMPELIAQTNMDLQSTNRLREELSKFTIWLSKNSGKYFATRYMTASNEYIEKSRGVPNPNPGTATSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WR31</accession>
    <name>A0A317WR31_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_585244</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468238.1">
        <property type="nucleotide sequence ID" value="XM_025615680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WR31"/>
    <dbReference type="STRING" id="1450535.A0A317WR31"/>
    <dbReference type="GeneID" id="37117823"/>
    <dbReference type="OrthoDB" id="2587363at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF5">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016351862" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="10">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="11">
        <location>
            <begin position="28"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY88876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="263" mass="27313" checksum="DF17652600D9F969" modified="2018-10-10" version="1">MSPISLFTGLLATASLASGVYAVEATDMGAAAFLWPPDRTWTATWDTTSPCGSSAGVGNRTEFPLTDGSVAIVLQTESYSVNLAISYDDNPTSNADFVTSVSGKSFPDVEPGHECYSVPNPPSNITSGANATLQLKYVSDFDNDGNETYYACADIVYVPYSSFTTDIPCFNVSEAGTTSSSSSSTSSSGSSSSSSGSQGLSGGDIAGIVVGSVAGAVLLGAAAFFLGRYWQKKVQREHAVAMNMMNPVQKTWSAETAGRQQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WR43</accession>
    <name>A0A317WR43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_557068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WR43"/>
    <dbReference type="OrthoDB" id="4231495at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="112" mass="11864" checksum="18D4784A22B24F77" modified="2018-10-10" version="1">MWILHGNVTERGDIGGGPGKSSLFFLTAYHPEIEPCTFAGSGAPPTILENPREGIVFTPGRTHNRSRSPRIGSKAGQPAGAPQHRGGDALGRLRPSGGRLTTNLELVRTRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSE4</accession>
    <name>A0A317WSE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_566006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467328.1">
        <property type="nucleotide sequence ID" value="XM_025614533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSE4"/>
    <dbReference type="GeneID" id="37116676"/>
    <dbReference type="OrthoDB" id="4161589at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF6">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="33304" checksum="1A55983FCA5EC8FB" modified="2018-10-10" version="1">MSSSTLTSADKKRLRDRRAQQALRSKKQQYTAQLEDKVAHCERYHDDSSTQHLMRVIEGLQRENEMLRRRQEGLKALVESWEELDLNPPPPLRHPITPSLLFLTLPPTTITTCPPSPNPLDLLYGTNTNPLAHAIYTHSLRRPLRDPERLAFGWLSYHYAKWLFDPSPSTFSHLPIFLHPVPEQLSIPHPASLDLLIWPEIRVNLIREWGSYTGQKDDLFGFLACCLKVRWPWGEPVLERDKGNELVVREEFLERFMCVNGWGITREFVGVYPGVVRGVDVGRVLVEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTZ8</accession>
    <name>A0A317WTZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_545836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468114.1">
        <property type="nucleotide sequence ID" value="XM_025613262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTZ8"/>
    <dbReference type="GeneID" id="37115405"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="104" mass="11696" checksum="8ADBEDAC9F7BB54D" modified="2018-10-10" version="1">MATADFFTFLLFVILMIFLLSTPSPPRISIWQMDWLHHPDINYGKGVGRICLPARDVKRSVEMGIPSTSKTLGRDQRLGELTLPPKILQHKPEDDSEGDAGTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUX8</accession>
    <name>A0A317WUX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_42734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468532.1">
        <property type="nucleotide sequence ID" value="XM_025607451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUX8"/>
    <dbReference type="STRING" id="1450535.A0A317WUX8"/>
    <dbReference type="GeneID" id="37109594"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="298" mass="33389" checksum="A8BE51B9C5726DE2" modified="2018-10-10" version="1">MPPTPVVTEHILINNHRIAYGIHSPPTSTSTTTPTPIILIHGTPSSSLIWRHIIPPLTTTGYKVHVYDLLSYGLSERPWDPKTDTSISGQVPILLSLLDHWSITSAHIIAHDIGGGIAQRFCILHPDKINILSLTLIDTVSFNSYPSERTKAQMQEGLETLIQAPNGTHREHFKEWILSTVTDTGKMRMEEEGSLDAYLEYISNPVGQASFFQHQVKHYDSRHTMEVAGRIGELGRVPVMIVWGREDRWQVLQWGENLKRCIPGAELSVIDGGGHFVMEDRPEVVGEVVRGFLGRVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WV61</accession>
    <name>A0A317WV61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468627.1">
        <property type="nucleotide sequence ID" value="XM_025611393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WV61"/>
    <dbReference type="GeneID" id="37113536"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="50" mass="6065" checksum="2FF0D8F664C6D040" modified="2018-10-10" version="1" fragment="single">MKTNAAYHYNNPYPYPYSYSPLNPPSPERKYIRYPLPSPPRYHYQSNKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVZ0</accession>
    <name>A0A317WVZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_545277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468924.1">
        <property type="nucleotide sequence ID" value="XM_025613227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVZ0"/>
    <dbReference type="GeneID" id="37115370"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="217" mass="24063" checksum="7DAD99F5AC70503C" modified="2018-10-10" version="1">MFASPARLAGEHEQRGQNMIDRPADGQTDQQQPTTGDCITTEEEKDWREGPTSGPPLQQIVHATSVLRNQSSFIRSLHDDRLNDNRPCVRIILRSHCGKVGTCVVLLHHPTASSAVRRSAMAVLDRSRASVHPSELRRTDLCGPPRRLLTCPVGPSVPSDRGQKTGGWMNRSTDRRMDLRQVPAPSRRLFLPPIADVYGSNQSQSQLQARSIQSAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW68</accession>
    <name>A0A317WW68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Calcipressin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_534338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468473.1">
        <property type="nucleotide sequence ID" value="XM_025611522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW68"/>
    <dbReference type="STRING" id="1450535.A0A317WW68"/>
    <dbReference type="GeneID" id="37113665"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000503">
        <property type="entry name" value="Calcineurin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="296" mass="32374" checksum="9B6E84AB0B58C722" modified="2018-10-10" version="1">MNMNTSPPQYLTSSPSFGARRSSASSRPALTLDLTNLPPLSQPTPPSNTLIITDLNDLVLFQPNSLATLRAYLESLAPLNSFSPLPSLRRIVCSFHTDSDALRIRKLLTGAPLLDRPVRPKVYFGEPTPILADMESRPKLLEAPQIDKLFFISPPPSPPHGWVMRQEDPPNKEVHASDLAHALAKLKTEQSGAEVEPVPTAMASIEPGTPMSMTSDKRTGSWPVALSQTRSRSSTLIYHPEDHGGSPNLPAVMVEDTSAFPDEDMDMDVDMSPIEMPVKKMPPKTSRPPVELMEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ14</accession>
    <name>A0A317WZ14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_27278</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468885.1">
        <property type="nucleotide sequence ID" value="XM_025606574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ14"/>
    <dbReference type="GeneID" id="37108717"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000784">
        <property type="entry name" value="MFS drug efflux pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY90507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="578" mass="62384" checksum="6181DA8415274153" modified="2018-10-10" version="1">MELVDQSSRSQSDEKTLAEPPPSGNVQRKFSHQEVIAYDETGAPGESPMNFHRFMGFTAMAFLWTGSQIPVYLFGGIPPYVYGDIGGADRWVWFVLANLLALAGVCPFVGSLSDLIGRRYVALIGTSLVCLGMIVSSTAHTMNIFIAGMAISGAGAGINELTALAATSEMAPTRERGKYVAVLIFTILPFCPSVLWAQLIAAHSGWRYVGAFCGAWNGFGLLITALFYFPPPRVNSEGLSNSEIVSRIDFVGGFLSISGLIVFLAGLQWGGYQYDWTSAHVLVPLILGFMVMVAFAFWEIYGAKYPIFPSRLKQEPRILGLTLVITFISGANFFSVLMFWPTQSFNMYGHDPVDVGVRSLPTGFGIMAGACIILWLLSVLRGHNKELLIISSVLMTAGCGAMSIARLDNLYQLWGIMVVAGLGIGGIIVPASIITTIICPDDLIATISALTLSIRVAGGGIGYTIYYNIFISKFVPNAEHYIGGVMLTELNITNTAYIKEAIELTGASLLDELHLIPGIAGNEAAYDAVVTAGQLAYTESYKWVYYASIGFGGVSIIAACFLGNIRKYMDDHVAVVMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1B1</accession>
    <name>A0A317X1B1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_461471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469699.1">
        <property type="nucleotide sequence ID" value="XM_025607926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1B1"/>
    <dbReference type="STRING" id="1450535.A0A317X1B1"/>
    <dbReference type="GeneID" id="37110069"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF77">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="780"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="881"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="824"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY91971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="926" mass="103227" checksum="E43FFBCA4BAFA81A" modified="2018-10-10" version="1">MQPQSEKPKRAPRKHVTTACVPCRESKIRCDGATPNCHNCEKKGKDCKYQHGDDKRNAVSAQPTKADFNSPRVSLRAATELFSARIDQLCQFIYDNGLEPPPMKPEDESGMNRVLDTLQIPRGLAKRRDSVASIGHNALPQPAVTQSPDHTPPPLPSGNRQMGVTESMPAVSSPSHSVLSNQRFLPPAEKSQDHMNTLAINPGLSTNYPSTHWGFTLPTAESLDALYANIDGASSRSNENSLSPDSLQFTPDISQQPGVLLGQAWNDRDNDSDSGEEDEAEKDVIEQISHRIGTLKIAGDGHLRFYGATSNLNLVDVSATQQRQRPDARTVRHDGQDILNHLRVGQPVDPALEDHLVELYFTWQNPSTYVVDKDMYMDARMKWRNDLIDTPFYSEVLTNAMCAIGSAFETRYHTTFITFPKSLSEFFADRAKALLEIELDSPCVATVQALVILSSHEGSSNRDARGWLYSGMSMRLAFDLGLHLDTTPYVEKGDISAHEADVRRIAFWGSYTADHFWGFYLGRPFRMNAGDITIPKPASDLGAEKEGMWYPYGLPMKPDALENGLKNPNELISRQFAVLWEIISPVGHILLYGCSDIPRHDLQRLCHRVTDDLFAWKANLPSNLDVDLGNDAVPKLPHLLVLHMQYHQIVIFTHRPWVSKSYIQPRSPRQGPGYHHARRMCVDSSIAIARLLHIYEKHYTFRRMNNQVVAIIFSAALMLLYVTISSSRPGGDSSSSNAEMVAYLNLCFRALDEIGQSFENAKRTRDFLVSLQRRWQAHMRRSGALKRQTSHQPLTQQPTGRITDPEASRKKSRVTAPRNQAAIPLSLPTSSSLTGAGLSFNQPQPQRRPGQPSFDPSQQLGACQPGDLDWIRDSDLQLLSENLGDNGFPQPGNTNSYGDDPALPSLADIEPWWDSPNVNTFGGSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3U9</accession>
    <name>A0A317X3U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_366200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470050.1">
        <property type="nucleotide sequence ID" value="XM_025607196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3U9"/>
    <dbReference type="GeneID" id="37109339"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19937" checksum="52FC669D5B38B535" modified="2018-10-10" version="1">MTEIGGGSQRKKPGKTRRGDSVTLREVKLLMRRANGGGRATRQVWPLTLGRCNGQRSRIGRSHRMLRRAVDSVYDYDPSESRLGVCTGVIDCEAMSYHLTLLTHFQTQLPTTPVIECVLDSPKASWPALRTGQVIIGSCMVWVRLDTLHRQCSSSKHDRMAVRSIHIRNRVSRYSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X452</accession>
    <name>A0A317X452_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_617059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469456.1">
        <property type="nucleotide sequence ID" value="XM_025616818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X452"/>
    <dbReference type="GeneID" id="37118961"/>
    <dbReference type="OrthoDB" id="4851482at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="790"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="850"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="890" mass="94599" checksum="E48FC6619830FC30" modified="2018-10-10" version="1">MTSWSWECASAGLVDSTEFATLGKDFLDDFLEKLETDDSLRDWLATPGSGGAVTTQDIHYQESGLANTMVQEASEQGHSGITPDTSNIFPDQAIAMDQANLDNYGISMAYESGSVPALEDYDTAAVLDELEVLNSGQFDVSAISQGGIMSSAHPSMSSLHASQANELPANYYGCATPNMIGTVAASSQHLAMKQAGNAFSQPYSSSPFYSYGTSTMDNGSMSSYVSTPMEQTAPHFVNVPNTRFNHGLMSQMSTPPSQRAAAGLAQGFVTPINQINRPNTNRSDTASSGNSQNMRRYNAAPLMAQAVTGAASHFITIPTPVCQTMNPSQQQVEGKSTGKTKLGARSPANNSSASGSGPDMNSSPPAYLPGQLGTVNGVQGSVSGSSGSSVKRYTSPRVKPATTPVPSIVQNTGDRNVTASSPSVSSSPTPVAADTATQIATALRSPASLPRPSVVPDIVQLMDPVTFNVDVETTYSSLTEAREANRTASGPREDDTLPTTDIQKRAIVKALTNAMLSTKSAEDNPGMVKPFHEGKFGSARVEAVCWELLESVIARHTSGSLLACYGIKRKGSGESMTFTERMTRILQCLSTQKTICKHLLDPLYMHQFVDDPLSAYKRVIANKTLNKRKGEVMNAGKQVLGAKRTNATTTQSQEVKREEPNSSINITPTNTPGSATVNRRKIFATPTATFRQTAANLARHAANNNMLPGTMDVGAHASLAQAARGSPSLSLGRMPTTNAHTNRMMGATSHPRQNVAFNSLTPNSQPPSHVKPLDTLYDPEAMLGSLIQRNMSNPNANPNANPNMNPGMASSVASNMTPSMAPSMNPGMKSRMNTGVNPNANPKMMHANVKNPNTQARQQQQAPGATTGPRKRTLSDTNFEDQPPSAKRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X486</accession>
    <name>A0A317X486_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_621839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470205.1">
        <property type="nucleotide sequence ID" value="XM_025617024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X486"/>
    <dbReference type="STRING" id="1450535.A0A317X486"/>
    <dbReference type="GeneID" id="37119167"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY93444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="292" mass="31344" checksum="6C14EF414A0D959F" modified="2018-10-10" version="1">MSMGSDCNVHGLEFREAKPSQGDPSRPVSELFRLDNRTIIITGATGFLGTTLAIAILESGGDVVCLDLASEPTASNWNEVQATATKYSGQLTYYPLDVTDETAVEKTFAHFIPTLRYPLKGLVACAGLSRNGPATEFPVSTFRRVLDINVTGTFLIAQATAREMMKTNTTGSMVFVASMSGYVSNKGVDTAGYNASKAAVHQLTRSLAAEWGSRLGMPLIRVNSLSPGYIRTAATAEALQKPGMESQWIGDNMLFRLSTADEFRAPVLFMLGDGSSFMTGADLRVDGGHCSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4A6</accession>
    <name>A0A317X4A6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor sulfurase</fullName>
            <shortName evidence="4">MCS</shortName>
            <shortName evidence="4">MOS</shortName>
            <shortName evidence="4">MoCo sulfurase</shortName>
            <ecNumber evidence="4">2.8.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor sulfurtransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hxB</name>
        <name evidence="7" type="ORF">BO94DRAFT_486572</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:42636"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:82685"/>
            <dbReference type="EC" id="2.8.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.9" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4A6"/>
    <dbReference type="STRING" id="1450535.A0A317X4A6"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008265">
        <property type="term" value="F:molybdenum cofactor sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03050">
        <property type="entry name" value="MOCOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028886">
        <property type="entry name" value="MoCo_sulfurase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="6">
        <location>
            <begin position="653"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="635"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="834" mass="92706" checksum="71025785E7A7025F" modified="2018-10-10" version="1">MLASRHKGESIVEYERQYPEDVDVIREREYPLLRGTTYLDHAGTTLYAKSLIESFSRDLTSNLYGNPHSMSAPSQLSTQRVDDIRLRALRFFNVDPEEFDLVFVANATAAIKLVADSLRESTPQGFWYGYHVDAHTSLIGARELAGIGNRCFMTDAEVERWISELGTEPGHGPRLFAYPAQSNMSGQRFPLEWCERIRNSAENTYTLLDVASLVSTSPLDLSDASAAPDFAVLSFYKIFGFPDLGALIVRKSAGHIFDKRKFFGGGTVDMVLTQGAQWHAKKQSSIHERLEDGTLPFHNIIALGSAFETHERLFGCMANISSHTRFLAKRLHDRMTALRHHNGEKVCHVYRSPHSDYGDPSTQGPILAFNLRSSQGAWIGKSEVEKLASVRNIQIRSGTLCNPGGTAASLDWTGADMLRHFSAGLRCGDDHDIMDGRPTGILRVSLGAMSNLNDINNFMAFIEEFYVEKSPSMCALVPPMETNLAQRSGFHVESLSVYPIKSCGAFKVPDGQRWEIRREGLAWDREWCLIHQGTGAALNQKRYPRMALIRPFIDLSRGVLRITCGPVHSPDQKTLEILLDRESTSLVSTSLCQNSSKPSTVCGDQVVVQAYSSPAVSSFFSDFLDVPCTLARFPPQTSTRLAEPRRSPGGRRSPLRPTMPGSFPQDPPTPEAERSPILLSNESPILLISRSSVNRLNETIKSGSSAGNVRKKAVAADVFRANIVVAEDFPQRGSAERPYIEDHWESLRIGSEYLQFNVLGSCQRCQMVCIDQLTGVRGEEPYSTLAKTRKSGNKIYFGRHLSISSSEHAWDNYDNPKPRTVMVGDVVSPSYGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X513</accession>
    <name>A0A317X513_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAAX prenyl protease</fullName>
            <ecNumber evidence="15">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_532582</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 15">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="15"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470414.1">
        <property type="nucleotide sequence ID" value="XM_025611149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X513"/>
    <dbReference type="STRING" id="1450535.A0A317X513"/>
    <dbReference type="GeneID" id="37113292"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 14 15" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="17">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="16">
        <location>
            <begin position="230"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY93653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="456" mass="51630" checksum="B5A774AF35A02A87" modified="2018-10-10" version="1">MYILEQLARLLDRPFIPWKNVLVGFSLGQFLLEGFLSLRQYKVLQRTKPPQVLAGEVSQKVFDQSQSYGRAKAKFGLVAGLYGQIQNLAFIYGDVLPKLWGLSGLLLAQYFPSRFQGEISQTLLFVFGFNLISTVLSLPISYYNTFVLEEKFGFNKQTFGLWVSDMLKGQMLGIVLGTPIISAVLKIVQKTGNSFFYYLWLFGVFLQIFAITIYPIVILPLFNKLSPLEPGAIKTGVENLAKKLKFPLQELHVIDGSKRSAHSNAYFYGLPWKKHIVIYDTLIEKSEPEEVVAVLSHELGHWSLSHTTKLFGIAQFHMFYIFALFSAFVNNKSLYQSFGFYGQQPIMIGFLLFSDALAPMDAVVKLLMNILSRKFEFEADAFAVGLGYSEQLAQSLLKLQIQNLSTMDADWMYASYHYSHPILSERLKALGWKGGKVTGLKEEDSETPIKASDREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X549</accession>
    <name>A0A317X549_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470477.1">
        <property type="nucleotide sequence ID" value="XM_025611164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X549"/>
    <dbReference type="GeneID" id="37113307"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="65" mass="7590" checksum="CF1FCDC2D2D4EFAD" modified="2018-10-10" version="1">MGKRVRYWKLKVVDVIRSNRRVSPVPIASDERKTSGGRRREAPRQHVESFKKRRDHLSPPPAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5S0</accession>
    <name>A0A317X5S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_572499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470715.1">
        <property type="nucleotide sequence ID" value="XM_025614925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5S0"/>
    <dbReference type="STRING" id="1450535.A0A317X5S0"/>
    <dbReference type="GeneID" id="37117068"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17132" checksum="2B34B20152BCCC92" modified="2018-10-10" version="1">MQLLVNTSNPDVLSIPDPRSYSPRPAPPPSRRGQLHISNSHLLPPTTDKHLKTCPNLKPTPSPPPTHFHQLQTTTPHHTNKKSTKMIFKTLTHLLNTLDELTEIGHSLLSSTLIAQNSHGDHPLYTSYALSLASTLPPPPPPSPSTKPSKPPPNCAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5Y2</accession>
    <name>A0A317X5Y2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_615736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469793.1">
        <property type="nucleotide sequence ID" value="XM_025616770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5Y2"/>
    <dbReference type="STRING" id="1450535.A0A317X5Y2"/>
    <dbReference type="GeneID" id="37118913"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="57060" checksum="79AB72C0E141E3B4" modified="2018-10-10" version="1">MKQLSLPTLGRRFFKKSSNINISIRLDDTVLKPYYAPGDRIQGVVTVTVDKAVQFSHVNLIFEGSTQVTLLQPKTVLRHCEASHKFLQLYHPIKEDCITPGLFQPGVVYTFPYIFIVPDRLLSGSCTHPTNEHHIHQTHTQLPPTLRVTNVSQAVCQVLYAIKFTVARQSSKDGPLHKRETLGSETRHVTVIPTAAREATSSIEDIFNYANSSHPSQLFVRQRNVEWPLKQQGFPKGSPSSTSRSATATEIQLSASENHHATPYLTTITVYLRFDPGTKTQEPPRIRKISPTLRTTTNYSTMPHRANPPLTKTDQQQLSYGGSHVETTPLTSLRGTTHIQWTRYRTIATAGDRPKYLISGNQNEEENTPIVADEPQCDHYYTAAIEVPISLPKKQDGKGGLLLPTFHSCYVSRVYVLELCVSYCSSSRTRIPQSTVVEVPVQVARRTSNAGGSMEMLCEKQGKTMSSLSVNNCYARCGLVSTIKGTEQMDLPLLPGGREPPELPRYGDAVFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5Y3</accession>
    <name>A0A317X5Y3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_357312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469728.1">
        <property type="nucleotide sequence ID" value="XM_025607146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5Y3"/>
    <dbReference type="GeneID" id="37109289"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016425749" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY92967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9152" checksum="0A4091D609653E5D" modified="2018-10-10" version="1">MPYILADQCPAIVMLFLLLNWLFQSYVCSRPHPTLSQVLSILRGSHQHAYQNQGQVHIAGTPSHYESGISMIHRNGSSQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X645</accession>
    <name>A0A317X645_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fructosyl amine: oxygen oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_532871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469863.1">
        <property type="nucleotide sequence ID" value="XM_025611212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X645"/>
    <dbReference type="STRING" id="1450535.A0A317X645"/>
    <dbReference type="GeneID" id="37113355"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF45">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="432" mass="47894" checksum="71BEC9FCC91CF556" modified="2018-10-10" version="1">MDKDSRIVIIGAGVFGLSTAYQLASEGYRDITVLDRHMPPVTDGSSSDISRLIRFDYADDDYLQLAHAAYLKWQQPKYQGIFYPTPFIFTGSSTTHGQAWIAKATAALTNHQLPWAKVQDAAAAKRLYPNLTGELAAPPFTGYENKQAGWADANKAISQLRDDCLELGVSFICGRRGMVVGFDTDSNNAIKAVRTLTSGPVEGDHFVLAAGAWGSSLVPMYNSTLTTGQVLGYMRLTPEEVEKYRELPVYINFSTGWFNFPPHEDTGLLKMAVHGWGYTRTPAKGESTAVKTNPSMPPLIPPRERRNFAPADGEVRLREGLREILPELADRAFERVALCWYTDTPTGDFIMDFHPDFKNLLIGGGGSGHGFKFLPVLGEYMSLAFKKSLPPHLAQKWRFRTDYQNRDDVFLGDGSRGGPARRELEAGERAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X657</accession>
    <name>A0A317X657_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_553945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470877.1">
        <property type="nucleotide sequence ID" value="XM_025613683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X657"/>
    <dbReference type="STRING" id="1450535.A0A317X657"/>
    <dbReference type="GeneID" id="37115826"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43060:SF17">
        <property type="entry name" value="L-THREONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="1">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="173"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="2">
        <location>
            <begin position="315"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="436" mass="45624" checksum="D3499F09F113E181" modified="2018-10-10" version="1">MSKPAIGFVGLGAMGFGMATHLVHEGYPVYGYDVFPASVQRFQAAGGIPASSLRESAEGKSFYVCMVASAPQAQAVLFGDEGIVQYLPQNATLLLCSTVAASDAQSVAAELASRGRTGIHFVDAPVSGGAMRAANGTLSIMAGGSDSSLQIARDLLQEMSAPTKLYLVPGGVGAGSNMKMVHQVLAAIHILGASEAMGLAAQLGLDARSTAERIKGSESWTWMHENRFPRMVEEDWNPGASALTIILKDAGIITTSARQSHFPIPLCATAEQIYLSALLQGYGPKDDSAMVRQYYPHPIKDVDTSSAKGDPETATQLVLDLMQGVNLVAAAEAIAFARSLGVDMAQFFELVSDAAGGSKVFVTRGLEMIEGKIGAQAPAGTETIDEVVSRLERVVQKARDLHCPVHLGNAALSVLLMAKGKGLGREGSTSVIGVYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6B5</accession>
    <name>A0A317X6B5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_459068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470927.1">
        <property type="nucleotide sequence ID" value="XM_025607824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6B5"/>
    <dbReference type="GeneID" id="37109967"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="14489" checksum="22C46B70316560C4" modified="2018-10-10" version="1" fragment="single">GLSVWDLPEDQKLFKDIDPFEVHEYSELNHLSLISALLGPVPKELLDKGTRTDLFYKSDGQFKGTTIAPLNFTFENSLRNIHNEDKRMFIEFVQRMIKWHLDERSTAKELLQDPWLYADFDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6R5</accession>
    <name>A0A317X6R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_563712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471020.1">
        <property type="nucleotide sequence ID" value="XM_025614371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6R5"/>
    <dbReference type="GeneID" id="37116514"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="30"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="354" mass="40019" checksum="08B34C26A311B728" modified="2018-10-10" version="1">MEKAHEDQGPKLTVINTVFIALATFAVIGRLCARRLRHLILGPDDWIICFSLACNWALYGIFAGCRQNGLGKHIDAVSSANVAKIAELLYVFQIFYALGPTSVKLSLLFLYRRVFERSNFLHLVYAMMALIFVFGIIVTFMAIFNCTPISAFWTRQGNCFNFASFALGYAVVNIVTDLTIWFMPIPIIWKIQMPKQQKVALSLIFALGLFDCGAAVARLFLSMLVLKTRDITWYYAPGFMWSVIEVSTGIVCTCLPTMRVVLEAVLRSRIARKLGLSSGHDSAQRYSDTTWPGSIGYNEAGDPRRRKGPNHIDRNFLELQDPEWDAYSQRGIMLYQEVNVELPPLRMQVSSRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7G4</accession>
    <name>A0A317X7G4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_509105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471304.1">
        <property type="nucleotide sequence ID" value="XM_025609690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7G4"/>
    <dbReference type="STRING" id="1450535.A0A317X7G4"/>
    <dbReference type="GeneID" id="37111833"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="10"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="235" mass="26152" checksum="87493A41C1EF8313" modified="2018-10-10" version="1">MAGIPFPPGITNNDIKGFGSSALAALDPTTNLIIKFPFVTTESTKCDHEREIYERLERSSHPRPPSILNFHGTTPHGILLEYAPHRTLRHYLRDLDTPAPISMILRWADQAAEGLQFLHENGICHGDVDCSKFFVTEDLNVKVGGFTRSTEATSDGLKKDIVDFGSAVYYMVTGYMPYQGLGGEEREEMFRKHEFPDLMDVELKAVIFPCWAGSYEGFGGVVGDVRGYGRFLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X961</accession>
    <name>A0A317X961_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_532098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470898.1">
        <property type="nucleotide sequence ID" value="XM_025611053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X961"/>
    <dbReference type="STRING" id="1450535.A0A317X961"/>
    <dbReference type="GeneID" id="37113196"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08620">
        <property type="entry name" value="PI-PLCXDc_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52690" checksum="2F081AFF738F4FFD" modified="2018-10-10" version="1">MPSKGLSVYSYIGVPGYAVGFAVPQQEVLRDASHNFTSHQLEIESSNIQGLDNFTGRYEWTVFRYGEPVADAHNDINTLTGKIEGGTMVATQDFHPIITEDAIITYGFYAAGHGVVGLTNRHQSYVTICSRENRSWMGSVAPPGSPAAQQPFSRFVLAAPHDNGMNSMMTCDSIFDHLNTDMLAVVRKLVPLFEHVNHVPDHFLMQKLPHIVYGLSVTQKKTISIMLAMGARYFEFRPAKLLPMFQKVSALRDTFYFQHACIPGLAFDEFLREQVAFLDENQTEMVTIHIRWDNIVADCKRPTMDETTQLLNEACARAIRSPLTWGARECFDQPIEDLRRTGTRLIVVIDADKYDSWTAKAYATLSADSIIGRFETMTTEGQESSDLTILQCQATSQSIKEVLVYSVVSAQGASSCLTSTKGMLDMRTLPWIRENALDRLRAEKTIVIMNDFIDGATVDTSILLSKQRLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X968</accession>
    <name>A0A317X968_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rho GTPase activator Rga</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_288593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471646.1">
        <property type="nucleotide sequence ID" value="XM_025606687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X968"/>
    <dbReference type="STRING" id="1450535.A0A317X968"/>
    <dbReference type="GeneID" id="37108830"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000044">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000121">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="8">
        <location>
            <begin position="897"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="135"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="531"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="836"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="686"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1090" mass="120213" checksum="382381C84C46BBC1" modified="2018-10-10" version="1">MESPAYPESPMDQDDIPFPCKGCGEILEEGKAFELAGNRWHIECFCCSTCGTLLDSDAHLLLLGDGSLICSNCTYSCSSCGNKIEDLAILTGEQAFCAQCFRCRNCKRKIENLRYARTSQGIFCMDCHESLMQRRRKRNRNVPPSRKQPPGIKLDKSLPSLPSEEAEPRSHGSDDPAADAYSDTTPDATLRGAAPALDAGRGRSSSATRAPVDNQDNLILPSSTYRSNRHSIIPQTEVESGGEFLIPVAFDPSEEQRPPRGQLPSTTYQKSPQESETSSPHIAYQEKGRDRVDLDAARWRQDDLANGLNTARSASARSSRSDLGRKETSTFSTPSPESTKSATAQRDGLASDFQRAAGDNIATLPIRPSHELRRLHETTGSVDSSHSFLSSSSIQHPKRADSLEGRLHQAPRKEVGTSPRPPSVTPSDQWSERSTDRTGASKSTPRTGESAWTPRSEVNEPPKPPARPNSISTLQQVEAYRQTDGAGSPSLLRYSGGADFTMEEDMARIMGSDDGNSTQTSESFLRRVSNSVRHGRSYSDKGSRLSRDAKWPKSPVNGSAAIPDLASISPENAGPEEVAWLRSELRKERQRVFDREQKIAEMEAMLNASADVKQVNTELHEKRSTMVVLDAQKEIAMRELSVLTDHLEAEKRGGGGSLDLGKLTNHVLREFVESISKLKETFTPQIEELVQKRNEAAEELANLNRMKDKSFQEFEQLSSKNAQLAELNNQLVHQIQELYKANPTDGRGANGLGIYSHGKEKSLSAIDALKAANSDLVPTIATTNISEEVEPATATIVPGPQVVSIRKGQPRKFNWKKGGQNVAKGVTKGLKGAFMSSENAPAEGNPGLPRSQTQDPSRPGFGFFGNPRSKQTGLRMPQTESVPVLAEATTPGGLFGTDLEQRMEQEKSIIPAIITRCIQEVELRGMDMEGIYRKSGASSAIQTIREGFERSPQDYDISDPDLDIHAVTSALKQYFRKLPMPLITFDVYEKVIDSGEIASQSARIESLQKSLRDLPRVHQDVLEFLVFHLRRVVEREKENLMTSQNIAVVFAPTIMRPESLAREMTDVQKKNEVLKFLVENCQEIFMGMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9I4</accession>
    <name>A0A317X9I4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_531069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471920.1">
        <property type="nucleotide sequence ID" value="XM_025610820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9I4"/>
    <dbReference type="STRING" id="1450535.A0A317X9I4"/>
    <dbReference type="GeneID" id="37112963"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="731"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1167" mass="130377" checksum="FBB8B1F0FD98F54D" modified="2018-10-10" version="1">MANEGFGAPTNGAHSAPSHKRQPSHVVKSVAPDYYEDNDFYANSTTSRPSPAPYPANSSRVHSHHRSRSYSARSKSYRRDIYPEDDMEWKDKPPASEPPAWSETSAKPSTTRGEKRGDDALKAPASSNSQPSPISRSSTIRSTTEQRRDWAADRSPLQKLEVTYTGASKEEKRARALEAEMKLRERMKREADSRATASAQPFDMPEHTDQPVPRAKRSHHRHAASEGQAGYNPSGQNPSERARPPRSRAPPPQSAAEQPFEEARYVDERLQDAPVRRGSAPRRTVSVKHQAQGPPMGPRAMNQGKQRDAQAYPAVAQDPAVPEQPRMAVPSRKAVPNQPQSRALPYPELAALQNTSPPQLAPERGPAIQGTTAQQGIMKNPTGVAPGFPIPANVSMERGMGDTNPMMPQSAVMETSALSKPKVSFNVPPPTPPPLFEWRTASVARLGASDFDFQRFDADRSKAWWETGESNDRRTSRALPNSFVQKPSAQKQTGKELGKRRIVTRSSVTDDMLYTGNKRFQPSIFLQSGPLLRYAGLKRVRIDGPNGPFNKETWRGSVLIVTQDSLSCYESRPTLRLFAQAMDLLAPPPVQVNGEDAQLAPEYVDPAAGLMKLGRDGRPLYVKPVEHTVEGEDLSFVENDDGIYEMSPSIMDYSSEGVGQPIPASRLHPMDGEAAGSYKEISGARLYADPGRDVTFWRFNIEIELGPTQQRVAYRLNQGPALGFWVPARGQSMNVMFHTGNGFSPAVDSNKLSGPDPLWRDVLNEHQTRPFHVMIGGGDQIFNDKVIAETAHFQEWVKIKNLSEKYESPFTAEFKAELEDFYLENYSAWFSQGLFSLANSQIPMVNMWNDHEIIEGFGSYPEEFMNSPVISGLGSIAFKYYLLFQHHSVPEETEAEEPSWILGAKPGPYINQRSRHLFMSLGDGVAFLGLDCRTERMTDEIICEETGELIWDRCHQEIVRGETRHLIVSLGIPLAYPRVAVVKNILNSRKSLGKAGLFGGLVNKTGAKVEIFDDHWTAKRHKAERTYLIEDLQDLAAEKSVRVTILSGDVHLAAIGQFYSNPKLNVPKDRDYRYMPNVISSAIADMPETEMISDTLNKRNHVHHIDTNTDEDMLSIFTHDVNNKPRNNKRLLPRRNWCSIREYQPGKFHPQLLFSSETGKKLYLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9P4</accession>
    <name>A0A317X9P4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_224416</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472067.1">
        <property type="nucleotide sequence ID" value="XM_025606243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9P4"/>
    <dbReference type="STRING" id="1450535.A0A317X9P4"/>
    <dbReference type="GeneID" id="37108386"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF169">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="467"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="530"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY95306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="544" mass="59529" checksum="0710305F539F2FFE" modified="2018-10-10" version="1">MYDFTVGGEANPAVIRVGLPPASLLNFPPSELPATVPAPVVSEPTWYQPFNIPSELYNQLLDVRVPITIASVYAVTVVLVNRLNKSRGYKPWGFSQTRLFKLFVILHNVFLAIYSAWTFAGMIRAFRNSWPTRDDPNYVAAVADTLCKINGPRGYGNAATYDPTADQWMFRNPELSLGAGGVPDSTDLGRLWNEGLAFLGWIFYLSKFYEVLDTVIILAKGKKSSTLQTYHHAGAMMCMWAGIRYVAAPIWIFTLVNSGIHALMYTYYTLTALRIRIPTVIKRSLTTMQITQFVIGSAMAASYLFFSYTLPVGQSAPVPPVETPGVAVGAAGAGLVPWIKKLAFRAAGAEGLAENVGATEGSAAVRVLHVGPMVTCMDTSGQGFAIWLNVMYLLPLTYLFARFFVRSYLYRKEPGPRQPTHMHAAEKAGLDALKGVSREIRKAAEMSGETSEVTEDESVNKVKALRATKAQQKTAENSPIRTRATAAKQRTRAGNSDQDSDSGFSTVASKKSAKRTTKEEIQSSAAIVVDTKDSNPYEVLDRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAW2</accession>
    <name>A0A317XAW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="12">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_532045</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="12">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470849.1">
        <property type="nucleotide sequence ID" value="XM_025611037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAW2"/>
    <dbReference type="STRING" id="1450535.A0A317XAW2"/>
    <dbReference type="GeneID" id="37113180"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="65"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY94088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="135" mass="14927" checksum="CA8A3EE8D6687300" modified="2018-10-10" version="1">MSASADVLAQAKVEIGLGAIPEGKNVIIKWRGKPVFIRHRTQEEIDEAQKTEWQSLRDPQADEDRVQKAEWLVMLGVCTHLGCVPIGESGDFGGWFCPCHGSHYDISGRIRKGPAPLNLEVPQYSFPSEETLVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAW3</accession>
    <name>A0A317XAW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_455914</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472082.1">
        <property type="nucleotide sequence ID" value="XM_025607681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAW3"/>
    <dbReference type="STRING" id="1450535.A0A317XAW3"/>
    <dbReference type="GeneID" id="37109824"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48295">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48295:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BCNT-C" evidence="5">
        <location>
            <begin position="230"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="191"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY95321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="309" mass="34074" checksum="355DA2A64B0C4B9A" modified="2018-10-10" version="1">MSDSDDEEEVTAEPVAKKRKTGDNKNAQGPEELDSGDEATIQKAKAKKDKKRKGDEDEDEEGGTGGFVRTRAMKMRIGEERKPLAKIDGATVDVEALWAKMNASDSGIGGSLSQGEKKDDATSADGQKDGETRADNNGTTTSAQKPQTNYTEEMIKIKRTYKFAGEMITEEKLVPKDSAEAKLFLAGEKEAETVSASDMDHNKEPIKLLRRPLRRPSRFDPNPTGAIKKSWEKMPATETAGQENARGPKINTVEKSRLDWAAYVDQAGIKDELNLHSKAKEGFLGRMDFLDRVGANIEEERRNARLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAZ1</accession>
    <name>A0A317XAZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_531750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471573.1">
        <property type="nucleotide sequence ID" value="XM_025610970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAZ1"/>
    <dbReference type="STRING" id="1450535.A0A317XAZ1"/>
    <dbReference type="GeneID" id="37113113"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000033">
        <property type="entry name" value="Adenosine deaminase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="9">
        <location>
            <begin position="16"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="355" mass="39740" checksum="80799CAEDFF9BB1F" modified="2018-10-10" version="1">MDLSKPADPAFTKALPKIELHAHLSGSISRQCLHEIWVKKKAQDPTFSVEDPFVSMPPGKVDYSLQTFFQSFNKSIYHLVNDLPSLTHATLSVLTDFQNDGVTYLELRTIPRASPSCIFTREEYLTTVLDTISHFQSTQSSPQKMTINLILALDRGHSTQASALEIVDLAIAYRARGIVGIDVCGNPTKGDVSILRTAFAKAKANRLGVTVHFAEMAEVATPGELETLLEFEPDRLGHVIHVPEELKGEIARRRLGLELCMSCNVHAKMFDGGFLDHHFGYWRFQECPVVLCTDDVGFFCSPVSNEYLLAAEHFQLSRADVLSICRKSYEVIFGGEAEKERLRRLLDAFETKYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBI5</accession>
    <name>A0A317XBI5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CAIB/BAIF family enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_580666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472232.1">
        <property type="nucleotide sequence ID" value="XM_025615343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBI5"/>
    <dbReference type="STRING" id="1450535.A0A317XBI5"/>
    <dbReference type="GeneID" id="37117486"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="567" mass="62926" checksum="D05A4FDEA366D648" modified="2018-10-10" version="1">MAATSAAGNDYSPVRETRRIFSFLCDQAERLSLPTEVVERQDAVSFSSTHDEIYYPIPFKETETLAALKGVEGSVAGAIADLRYGPSQKRNVKVSLERATAFGSQAYMAKVDGLSKLDPEVKKKLKDTDLLAAQSNGYRRMSANLYKTKNKDEFFHIHGSLEATTTLNMIGLEGQRPDLTDYEDIIKVIESHVQKYSAAELEEMNKERRQAGVTAFKYEDFKNTPHGKLNVEEPPWKVTRLNGDLPPTPFPASRSGSKRILEGVKVLELCRIIAGPTVARILSEYGADVLKITSPNLSDVPFFQVDGNMGKHAADLDLKTEESRRQFEELLADADVLVDGYRPGALEKLGYGANALASLAEKRGKGIVYVNENCFGYEGEWAGRPGWQQIADCVTGIAWAQGKFMGFSTPMVPPFPISDYGTGCMGAIAALTGLYHRAKHGGSYHGKASLMHYDLLLFAVGQYSEAVQEKMRAAQPPEFFQLRHCDSVDRISSTVLKIMQKRFPHLYQSPEEAGAEALTEKWFSKAYNAEIEVVRPIAEIDGVENKFVRASRPNGTDRASWEFEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBS4</accession>
    <name>A0A317XBS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Oxidoreductase acuF-like C2H2 type zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_129987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472322.1">
        <property type="nucleotide sequence ID" value="XM_025605630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBS4"/>
    <dbReference type="STRING" id="1450535.A0A317XBS4"/>
    <dbReference type="GeneID" id="37107773"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF7">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase acuF-like C2H2 type zinc-finger" evidence="1">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="406" mass="45968" checksum="C74BDC6C91DB39B3" modified="2018-10-10" version="1">MAAEFSALAQSCLSLWGKLVSSGDLAAFSHEVPHSFWEDGLGRMSVCISDIGAHPIWQPSLHSRLRDASHIKYEVKRHLLRLKWIHDCLQNELFDLSDEESENGGEKMTDETMETYIQGLYYCLHDTIDSLYQLIRSVRLPACHNIFTRVKRADAAHFEYYDRRHVQSKYPNISQAISDRLGEAISIRRAVLQYYERLHTEISVISDAVSIRTLSEATTIKLNQEPTETLEVDAQSMMPQTLCSESVVQGGSGSAIPLPPAGSTYGAPFTCPYCFFIVNVKDQNEWIEHIFSDLKPYVCVLPDCQTPNHLYECRREWYAHMHDEHMTSLSVGEVSKCLLCGCEVTPGEVLEEHLAKHLEELALFALPRANVTDEEISRDNLPVINVLRGIERLSVTTRVSDAMAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBV4</accession>
    <name>A0A317XBV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_131086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472352.1">
        <property type="nucleotide sequence ID" value="XM_025605643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBV4"/>
    <dbReference type="STRING" id="1450535.A0A317XBV4"/>
    <dbReference type="GeneID" id="37107786"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="5"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY95591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="172" mass="20161" checksum="64D472A6BE2C6785" modified="2018-10-10" version="1">MGRLTEYQVIGRHLPTEANPTPKLYRMRIFAPNTVVAKSRFWYFLTQLRKVKKANGEIVSINVINEKRPTKVKNFGIWLRYDSRSGTHNMYKEFREMSRTEAVEALYQDMAARHRARFGSIHILKVVEIDNADTIRRPYIKQLLSKNLKFPLPHRDSGSKKVFAYSRPSTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBV5</accession>
    <name>A0A317XBV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_507540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472827.1">
        <property type="nucleotide sequence ID" value="XM_025609620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBV5"/>
    <dbReference type="STRING" id="1450535.A0A317XBV5"/>
    <dbReference type="GeneID" id="37111763"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="247" mass="26537" checksum="FFE288733D71D857" modified="2018-10-10" version="1">MPPSTNPIAIIAGAGPGTGAALARRFAQRYPVVLLARSQSTLDPLVQDINRSGGSALGIPADVAHTDQFSSTLAQIRTHFGSEPRVAAAIFNVASKFSRNPFLDHQPEFLDSIEATARGASNFSRAVLPLLLREVEKTEEYSPTLIFTGATAALKGGSGLGSFAMSKFAVRALAQSLAREFGPKGVHVAHAIIDGIIATEKTKGYMDDRPDAKIDPNGIAEAYWFLHTQSRSAFTHEIDLRPYCETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC39</accession>
    <name>A0A317XC39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_571545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472864.1">
        <property type="nucleotide sequence ID" value="XM_025614876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC39"/>
    <dbReference type="STRING" id="1450535.A0A317XC39"/>
    <dbReference type="GeneID" id="37117019"/>
    <dbReference type="OrthoDB" id="5295431at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="116" mass="12877" checksum="ABF739E8278A2294" modified="2018-10-10" version="1">MGEGFGHWKMRSHHHAQELPVAQSKVTTPELCYERALSPAMRDTSKNINDTEFRFGFGGKPFSICINSDTLTSLQNVTGVHQPVDEASRQRFPQPSISGIKGLTACTDSRIINVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCL5</accession>
    <name>A0A317XCL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_125709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472213.1">
        <property type="nucleotide sequence ID" value="XM_025605606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCL5"/>
    <dbReference type="STRING" id="1450535.A0A317XCL5"/>
    <dbReference type="GeneID" id="37107749"/>
    <dbReference type="OrthoDB" id="5582218at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="4">
        <location>
            <begin position="100"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="677" mass="73347" checksum="0129F78B0D68E3A8" modified="2018-10-10" version="1">MTSDPLRPGLHPLSHLKAGPTTSSSKSTAVPSSPTSQSFAQVSTRPQPLRNASREDPVNATSDKATIALIRRVLCPQTGNHGGALTPQPPKDLLPPLTSSNEVDRQLYALIAIVVKEFVFTWYSKITSDQMLVSEVLQVIAHCTRALEQRLREVDIAQLFLDEIPALIETHITSYRLAKQQSESSQISPSLRELYHALNPHPGLSPVPDQSDGQAIAQQQEIESIYRQLLVHGALSVLLPTEDLENACLRTLLGDILADLVLGNAVSGKVSEGWFLWESITKVVEMAGRKDKEDSVATATATATSTATATATLRQRSRLHKYGLLSKEELSKGHSSQAQVRVPDWIWQVLQYVYMIYVTLRFIVTGVFRVASAPPVTSSLTSCAPTSDADDTPSLCTTSGKRPVLNYRLYGMVSQLMDVPRRMPWLGGMLALIQYLILAGPGRLGDTDSVLDRFLHETIRDYVLTPALLPNLLLATRAALFPLNARPASTAADGRTAASAPHLSVQPPTPPITKGPVSDTAGASDACSSVSSPGLSATAPLSPDPRPSTPDVASIKRRCAASILSRVPRPIARRFFGVPTAPIEHRPERLDGSSEPESPWLDSPRAPSTVSPADCGLEESLLLAAIEEVLDLFADDYCNKHLIYSIIEVILVKLLPELSERSLTELMEDRGVPLAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDA2</accession>
    <name>A0A317XDA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_454263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473066.1">
        <property type="nucleotide sequence ID" value="XM_025607602.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XDA2"/>
    <dbReference type="GeneID" id="37109745"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000052">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.160:FF:000001">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="109"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="762"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="938"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1433"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1613"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="938"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1454"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1483"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1613"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1624"/>
            <end position="1640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1658" mass="186479" checksum="E47189E0EEC2FB6F" modified="2018-10-10" version="1">MESSPPRSSFAAPVAGVKRPASLLPAFEPLSSSPSLPRPQKRVARDNHGIVSTYPTPVPTSSTHIMSSSPPRMTLPRTASRRTLASSSSERAPLSDVPTIMLSESGEPVLMGRSSASCHHQLAANRMISRVHVKAIYKPASNPFDSGSVEIMCMGWNGIKLHCQGKTYDLAKGKTFTSDIKDVDIMIDVHDARVLVQWPRNDRKDYASTDSEQTWEETTPKRAAQSRQSLHESPNVERQRLASPVSPSPATKSLVPPSSPLYTPTRSRNAVVVYEDEASPVRRNNTEDVLAQDTRKSSIVEDIFQSSQSSDLSDLSRQDEFSDHDEENDPIIHSFGPFGDNLLPRMASFTADESPLRPARPRNQASAPLQSRQQLKSSESVESLTTKLEPLDESFERVQNHAVNQLAFSRLSSTPFSTILNNLPPTLWKRDSHHREGPSKDEIRAILDTTKCIGKVAREGKDAAGKPLESEYYYIPDYDEDDMRREAVVHDLRKPGLRNCRKQHKHVFWGDLRLQNERVWAGESDVFPVSKSLDSALKKNTAFIKRLRTGINAAAQQTFLTDIRTLSLHKYLSEIISACYEGLCKLKSPGEIATGVEITSALHQRFGPKEFTRQIGWLLGRGLSTPDKGQLKALSQEVREREEKERLSRHRVLLRVVTELWLVGVLKTLDDIEKPDDVGAKGKDGVVGLGGKAIDGPVKRIAPSAGRDGDREPEPFPLEVLKDLLGHDRDHSNLPLAVLFVKSFSWDVLGVKMVEEGRKTVEADGATTSAPAEAVNGGDEGAEQMPDADNDPPLTPEKVQLRFKHILNRYLEDVKAHVVRDQRALAAQSRRNAEAYVKSGEIFEDRQANFERQTKSLERLVANTQVLCEVLGVEMPALAEKEAADAGAGGGIGLVKASEYLRGQGEGAGIWEDEEERRFYENLVDLKGKVPAVLLEDGKKKKTETDEAGKKKADGEGAEAEKSEPTGQVQQAEEKPAADADDQSTAIASKTVGAQVDALLAKLPDLQTKDQVDQLALDFCFLNSKASRNRLIKAVSDVPKGRIDLLPLYSRLVATLGQYMPDIPQGITTYLDEEFRSLQRRKSKEFLGQVRMSNVRYLAELTKFGVVPEHIIFHCFKVSLDDFSRMNIEIIGHLLENCGRYLLRNPDTSPRMASFLETLGRKKTVQHLGQQERMIIENAVYYVDPPPRPAIQQKERTPMESYIRRIVYLDMNKRNYTKILKSIRKLHWEEQDVVDILERVFSKPVKVKYGNIHLLAILVSALYRYHQDFVIGVVDNILEQITLGLEQNDFKFNQKRVAEVKYLGELYNYKMIDSPVIFDTLYRIVTFGHENGTPMPGKINPLDLPDDFFRVRLVCTLLDTCGHCFDRGSAKKKLDFFLTFFQYYMHTKDPLPMDIDFLVQDTFSMTRPQWKLAADLAEATQIFSDAVAQNFKTQDAERPAEPDEDDAESSSSDEGLEEDAIPEAEEDQESSDEEVSGPNEQNGDSESEDEEIFVTRQEEERDPEAEAEFDREFEKMMAESMESRKFERKGVFDIPLPMKRSGREAMLENTPVETPKPIANTMAFSLMTKKGNKQQTRTIDLPSDSTFAVAMRSQQQADREEQQRIKNLVLNYEMTNETETTTEATEKRSPHRDTRMDKASTNRTAFRSRKLQLSDVNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDE7</accession>
    <name>A0A317XDE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative haloacid dehalogenase-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_529926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473320.1">
        <property type="nucleotide sequence ID" value="XM_025610557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDE7"/>
    <dbReference type="STRING" id="1450535.A0A317XDE7"/>
    <dbReference type="GeneID" id="37112700"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.720">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051828">
        <property type="entry name" value="HAD-like_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044924">
        <property type="entry name" value="HAD-SF_hydro_IA_REG-2-like_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46191:SF2">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="311" mass="34522" checksum="2F9ED2967C56D147" modified="2018-10-10" version="1">MSRPRTLLLTIDAFDTIFYPRHPIPDQYASVAHAFNLPRSTVTPARIQSAFKSVYKEQSRLRPNYGRADVLRGQYGGPRQWWEEVMRGCFKRVLAKSSTSTGEVHIPDGLFQSLLDRFASREGYALYEDAGVFFERLKDVRRGVRGLGVFERVVVGVVSNSDDRVPAVLRSLGLKVGGVRADEGIESLSLPGFEQRNVTTTNAVLDGDNGEDATVNDVDLVITSYEAGEEKPSPVIFDVAERQARRLVGNDQEGDWVRVHVGDDYDKDYRAAVDAGWKGLYLPRGGGALETRGGEAIRSLVDLIPVLEGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDL3</accession>
    <name>A0A317XDL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_570916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473405.1">
        <property type="nucleotide sequence ID" value="XM_025614846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDL3"/>
    <dbReference type="STRING" id="1450535.A0A317XDL3"/>
    <dbReference type="GeneID" id="37116989"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="702" mass="78921" checksum="F76F787841A0F1E9" modified="2018-10-10" version="1">MKRKVNSHLLDSSRFPKRTPRQDPVSCESCRLKKIKCDRQQPCSSCLARQLDCIYGRPAIARAPQPRPPAVVERGMHPNLDSPVVTTDRSSRPHASPSAPYNRESLRTADWLENIHLAERVSTATPKWLRDGLGDPARRRSSSVNLEAGPKPLLSMPYMSRSAIDENPASVNLVSFLPTKAEALGLFRYYHHYVDYLYHILIPKRVEGLMNGIYHCIDNGSPVELNHLALLFSILASSLCLQMALEAPGDAEARSQEFVYLTGAALIQSHYTASPTLEGLQATMVVMHNVSNWKIPSLVNGLFVHGAIVSQAKSLMLHCVDSPSFRNERDGSTYDAVELELKRRLWWDLASYDWLMGFLTGPQEWTYLIHPEHMNVNKPTNIDDDAIGTHGVVTLPSSTPTDMSFFLQRLKLAFVSRDVVDATSYEHLHGLEISYDKILELDRKFHEALAEIPEFFRLDAASRRRFASVYEERPTIAWQCCLLQQGFYSRLCRLHRDFFIRGAREPAYSYSHVICLQSARKVLEIKRIMDGNEPNHTPPNSVVWSVMHHVFAAAVILLLDVCFNWDDILAEKRKEEVLDACRMLSKAQESSSLVREGINGMMSVLQKHWKHSLVPRGENPSNSAIEAAPSLQGTSQAFLADSTAALNDDAPELPAATFDSIGGKQLEDIWSEMLNTGNDLTLEAADWTELLNELTDPDLPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDN9</accession>
    <name>A0A317XDN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_505431</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473052.1">
        <property type="nucleotide sequence ID" value="XM_025609539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDN9"/>
    <dbReference type="STRING" id="1450535.A0A317XDN9"/>
    <dbReference type="GeneID" id="37111682"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016191015" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="158"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="663" mass="73902" checksum="500B98B79167768C" modified="2018-10-10" version="1">MRRRTFLASLSVLYNCVSVEASLTILFQNDGNWTTHAEKPGALFISDALPYQDAQATCAQYNETLLSCKSYDDFHYSFTYQQYLKNIDSDQLFWSSCSSDHPTTWEGELANTSSSAALPFLCSNSAEFVKEVDTDYFVFPRVNTSANGVTFEGLRDHMAFRFLGIPFAQPPVEDLRFKYAQQWTEEPYVNATKYGPACIQSGWYDGNSYGLNPWGNSEDCLHLNVFTPSIPSSSDNSPRPVMLWIHGGGETEGTGADSTFDGDSFVSRNDVVLVTINYRLNIFGYLSLDDAAVPGNFDLTDKIEALKWVQKYIRAFGGDPNSVTIFGQSAGASSVIDLLTTPKASGLFHNAIAQSIAGHVETANASATAILPYIQPLCNSTGTERLECLQTLPASTLLNISSGVTWDTVIDGHYILDYPVPQIAKGALNRVNFLTGFMPEEAQSILQDSISPNATNFNTTLQTLVTSASITETQAQAVLSSGLWTNYSSPYNATIHVDSPAGMTCYSKEFAEVGAASHSYESLYVYLHQRAYGLNYYDWYDLCTYPVGKPETPYYRCHSGDLYEVFGTYYLFDLPVRSQEDIYYTNMVQDMWASFARTGNPNVDKDYLRARGYHSTLQLTTRWNWTQYEPDSAKVANLQYPMPFYSTLPYLEECAVLGLEHSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE48</accession>
    <name>A0A317XE48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_530636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472658.1">
        <property type="nucleotide sequence ID" value="XM_025610712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE48"/>
    <dbReference type="STRING" id="1450535.A0A317XE48"/>
    <dbReference type="GeneID" id="37112855"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="209"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="812" mass="91464" checksum="6689F35061E08C96" modified="2018-10-10" version="1">MPSDKSPVGESAPDLEIVGNKVTIHPSGVIGGPEPQDEQITERNLVRHMARFRENPFDFLREVSLYMSGTGWRAYDDVIGQPIFYSGFGDRMKSRILASPLLQGKVKELAEARLAVEEKDGLLDVNPGPLVEKRIHRRNEIEHNLKEVVDSMLDNMICKMESKRFIRGAYYLCTQLLTRAYHQGIHVSSEEVLRLRSFAEDAAAKKQSIVFLPCHKSHVDYVSLQLICYRLGIGLPVVVAGENLNIPMLGPFLQHAGAMWIRRSFGNDPLYNTVVQAYIDTLLQQGFNFECFIEGGRSRTGKLLSPKFGILSFILDSVLSGRVEDTIICPVSTQYDKVIETESYISELLGQPKRKENLADFLSSSSVLSLKLGRVDVRFHEPWSLREFIAQQLSRMPEQIITNGGPKLSYADRGRVLRSLGYRVLSDINDVSVMMPTALVGTVLLTLRGRGVGKGELVRRVEWLCERVRAKGGRVAHFYRYPTDVVVYRALEVLGPQIVGEVDGLVEPTFLAVDRFQLSFYRNMTIHLFITEALVSAAMYTRIKQGGGPSYQRMSYPDLVNQVSFLSQLFRGEFIFPPEGLTTNLEKTLRGLEKDDVITVSRDTTGPPLFVELSDAERQCGRENYDFYCFLIWPFIEASWLGSVSLLGLTPPLNGAEDVWIDLNKAQDSAQLLGKTLYHQGDLSYFEAVNKETLKNSYQRFAEEGIIQVAKSKESKATTMKLAAEWTPERDPITGKLVPRGRLWNFTELIAQSRREGKNRRDGATVSSRVLHMSDVVGRKLFEDASSRSPAEEVDVSIRQMRRKAITPSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEE2</accession>
    <name>A0A317XEE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_14468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473322.1">
        <property type="nucleotide sequence ID" value="XM_025605749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEE2"/>
    <dbReference type="GeneID" id="37107892"/>
    <dbReference type="OrthoDB" id="5389296at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="472" mass="51880" checksum="178DBCFDA132FB57" modified="2018-10-10" version="1">MPPVATPFRASRRNAGPQFASTPRFFLSQTPASSRPSQDVESIDHDDFEYATPVPTARTSKRLREHVPTPRQREIIEDSEAEPDEDATPPLHSKEGILDEEPQSSSPGEPGELDAVFEEIFGSTRNRTKRRLVSWTNSNDDTSSILRSKPRADAIATSSPDPPPPPLADNLTPSASYHTPNKALPEQRFRKPVRSAPEIQQPTTPASIMPSPLQPRRFVLSASQLPPSSQTQSGIRPPNSTATTPIPLSQRRTPAFVLPRSPSPTHEEDDLTGIPTPFSPSSRALRHRGGRRSAAPNYVPGGMAAEVRSWILEMGAKREQQQTSPSYYQRTDSSSPDTRKYSVTVRINSAHQTALRSCGSLAFVQGHPVDTLGVSSGPVTYDESQLKNVLLLGPPRQPTHQTRHATIRIPELKLGDTIGVCRGLAWEVDLGEHQNAQVSGTDLRLDDLSPLDRSYLQTAGKWHVGMEWELIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEK9</accession>
    <name>A0A317XEK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative rRNA processing protein Bystin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_453407</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473546.1">
        <property type="nucleotide sequence ID" value="XM_025607564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEK9"/>
    <dbReference type="STRING" id="1450535.A0A317XEK9"/>
    <dbReference type="GeneID" id="37109707"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="496" mass="55328" checksum="E67DD9100777F515" modified="2018-10-10" version="1">MPKATSSRSAAARRHNPLAEDYLTAGHLRTQSSKKTSRKSHREEDQEDGERFIDAKMSRKILQIGQELAEEDAAEQRVATGAATDKINSAFNFESRLEDDEVLSDDEKFQDDQWDDDEEENDEVEVDPDDLDMFHKFVPGGDEDPIFNPSGSDAEGQTKNLADLILEKIAEHEAKQAGDGAPFIQGGGLPEDAVQIPAKAVEVYEKVGMILSRYKSGPLPKPFKILPSVPNWPTLLHITRPETWTANAVYAGTRIFISSKPAVAQEFISTVLLDRVREEIHETKKLNVHTYNALKKALYKPACFFKGLLFPLVSSGTCTLREAHIVSSVIARVSIPVLHSAAALLRMCDLAAEQSLRSLESTGAVNMFIRIFLEKKYALPYKVIDALVFHFLRFRASDGAEDSMMTDEPSREANKAYKLPVLWHQSLLVFAQRYRNDITEDQREALLDLLLVRGHKDIGPEVRRELLAGRGRGVVAPDPENQGAIDAGDDTMDFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XET4</accession>
    <name>A0A317XET4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_506209</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473492.1">
        <property type="nucleotide sequence ID" value="XM_025609566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XET4"/>
    <dbReference type="STRING" id="1450535.A0A317XET4"/>
    <dbReference type="GeneID" id="37111709"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="496" mass="56780" checksum="BCECBF9B07B52398" modified="2018-10-10" version="1">MRPTFLTTTTTGNAAVTAPFVGSRHAWLARWEFFQSAQLVLQKGYSQYKDQPWKLTGNDVVVLPHKYLDEIRKLPVQRANAMKANLDNMQSKFTHLEILNSTRLFVHVLKRKLNPQLAILIPTVRRELDAAFTKEIPQSISEDEWTSVEAFHTLHKIVGRISARIFGGRELRDDEHWLNAAEGYLNNIFATAISIRLVPYGFKTLASWFLPCSWEISWNFWKAKRILLPYIRYRKRIIAQRADEISRMGKSEFPDVLQYLIEQAEGRDAEPLSLAAMVLSLSLASNHTTAMALTECLYDLCAHPEYQDELRQEVQDAIEADGGWRKTTLLRMRRLDSFMKESQRMHPPSLMGYKRKIIEATQLSDGLHLPAGAHVEFAIVPIQHDSVADPTRFDGLRYYRMRQTPAEAHRHQFATTSNSVLHFGHGQNSCPGRFMASNVIKMVLGTLLTEYDFKLDQTVRPDGISAFEYNFPNPTARVLLRKKKKKAPSPDGPTDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UV70</accession>
    <name>A0A317UV70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-B22</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase B22 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_570315</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Mammalian complex I is composed of 45 different subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000055">
        <property type="protein sequence ID" value="PWY65943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461522.1">
        <property type="nucleotide sequence ID" value="XM_025614796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UV70"/>
    <dbReference type="STRING" id="1450535.A0A317UV70"/>
    <dbReference type="GeneID" id="37116939"/>
    <dbReference type="OrthoDB" id="13598at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20263">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045292">
        <property type="entry name" value="Complex1_LYR_NDUFB9_LYRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033034">
        <property type="entry name" value="NDUFB9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12868">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B22 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="17">
        <location>
            <begin position="8"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY65943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="100" mass="11452" checksum="ECA3304BCAB9447B" modified="2018-10-10" version="1">MPLNAGASLYRRSLKLALDWAVHRQIWRGQAVYIRSLFEANKDVRDPRQQKVLLQETEKLLETWKHPDPYRAPTAPGGSKYERNIPAPQLPLASESAAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UW02</accession>
    <name>A0A317UW02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucoamylase</fullName>
            <ecNumber evidence="10">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_540805</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="10"/>
    <dbReference type="EMBL" id="MSFK01000057">
        <property type="protein sequence ID" value="PWY65626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461462.1">
        <property type="nucleotide sequence ID" value="XM_025612992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UW02"/>
    <dbReference type="SMR" id="A0A317UW02"/>
    <dbReference type="STRING" id="1450535.A0A317UW02"/>
    <dbReference type="GeneID" id="37115135"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016279642" description="Glucoamylase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="15">
        <location>
            <begin position="528"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="498"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY65626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="635" mass="67729" checksum="B3B51D8FA8EDA05F" modified="2018-10-10" version="1">MSLRSLLTVSGLVCSGLAGVLPKRATLDSWLSSEATVARTAILNNIGADGAWVSGADSGIVVASPSTDNPDYFYTWTRDSGLVIKTLVDLFRNGDSALLSTIEHYISSQAIVQGISNPSGDLSSGGLGEPKFNVDETAFTGSWGRPQRDGPALRATAMIDFGQWLIENGYTSVATDIVWPLVRNDLSYVAQYWNQTGYDLWEEVNGSSFFTIAVQHRALVEGSSFAASVGSSCSWCDSQAPEILCYLQSFWTGEYILANFDSSRSGKDANTLLGSIHTFDPEAACDDTTFQPCSPRALANHKEVVDSFRSIYTINDGYTTSEAVAVGRYPEDSYYNGNPWFLCTLAAAEQLYDALYQWNKQGSLEVTDVSLDFFQALYSDAATGTYSSSSATYSSIVDAVKTFADGFVSIVESHAASNGSLSEQFGKSDGLELSARDLTWSYAALLTANNRRNSVVPASWGETSASSVIGTCAATSASGTYSSVTVTSWPTIVASGTTSATTATGTGSAKSTTSSKTTTTASKTTTSCSTPTAVAVTFDLTETTTYGENIYLSGSISQLGDWDTSDAVALSADKYTSSDPLWYVTVSLPAGESFEYKFIKVESDGTVVWESDPNREYTVPQACGTSTATVTDTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXI6</accession>
    <name>A0A317UXI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_591266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461559.1">
        <property type="nucleotide sequence ID" value="XM_025616099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXI6"/>
    <dbReference type="GeneID" id="37118242"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016395831" evidence="2">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY66049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="199" mass="21125" checksum="15A06ABB5A9F77A5" modified="2018-10-10" version="1">MKFNILFMMTLLVVFVTSVAIPDIDDGDVDVNITLSDEDWSDLDLDFFDFDVADDVDDSDVVARDEDVTVAAEWTLNVAPVIGASGAFAWDLAVMLECVAAAAAGAVGAGDFGLAAADPAIRSDKPEMGGIRKYYVIVWESDDSNPASLDETRRDEMIGDEDPTSSVGGLIVREGKQERTGSFEKDVGLCVCSSGPAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXQ7</accession>
    <name>A0A317UXQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcriptional corepressor Cyc8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_479824</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461571.1">
        <property type="nucleotide sequence ID" value="XM_025608766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXQ7"/>
    <dbReference type="STRING" id="1450535.A0A317UXQ7"/>
    <dbReference type="GeneID" id="37110909"/>
    <dbReference type="OrthoDB" id="418911at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000163">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000282">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="156"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="418"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="506"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="458"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="575"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="692"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="721"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="760"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="839"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY66061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="867" mass="94195" checksum="7401229348A99370" modified="2018-10-10" version="1">MAHTQPSPTGGVTPHHGHIAAHPQVNGHLPLQPQSQKGPPLSTAQKIAALNEQVWLQIGGLTEMMGDLEGATNAYEQALRHNQWSIPAMNAIASIHRTKEQFPKAIEYLQNILKLDPTSGDTWGSLGHCHLMMDNLQEAYTSYQQALYHLRDPKEPRLWYGIGILYDRYGSLDHAEEAFSQVMRMAPEFEKANEIYFRLGIIYKQQQKFAQSLECFKYIVTDAPRPLTEEDIWFQIGHVHEQQKDFESAQAAYRRVLDHDPNHAKVLQQLGWLHHQQSNNYASQEKAIEYLEKSVSSDNGDAQSWYLLGRCYMSQAKYPKAYEAYQQAVYRDGRNPTFWCSIGVLYYQINQYRDALDAYSRAIRLNPYISEVWYDLGTLYESCNNQIADALDAYGRAADLDPTNVHIKARLQLLQSQLSGSSNSNAPAPQPQDVHPQAYQAPGVGAPPAPQWGAPAPTGGPPPQAPAPPRQIADWNRGINEIQSQAQAQAANGFDPRDVVRAAASLQQPSPRQEPGRGFPDAVRAQPGRSPKTTLTGPSVYAPAHALPQLANPPASALDRAASGATAFSPATRGPLPPAPAAPPAPGGPNGPASANALPPYHRPFSPPPEVRPLRDERPSSPGSTYPHQQYHHGPSVPVQGGSGGGIAGGAPPPASAISAAEAAAREREERPGSAMKRGREWEAEAGPVKKLASEETRARLDDQLSRRITPPNRMPSPGEIQRRSSSEIRREDQRRVNENYHPSEAAHHPPTLPSIQHMPPHPSGPSLPPMAESSAAASNGPPSGSASAQVQVKEEPTRSEQGPAHEPAARKMDVDENYDDDDDEKRAGAVVKGSPHASGSGSANNNSNGVLSGGNPPTPAKPESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXT1</accession>
    <name>A0A317UXT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_331586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000050">
        <property type="protein sequence ID" value="PWY66853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461789.1">
        <property type="nucleotide sequence ID" value="XM_025606981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXT1"/>
    <dbReference type="GeneID" id="37109124"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016289316" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8841" checksum="1F0F63ED0838D2EE" modified="2018-10-10" version="1">MPLRPVSRHLSCLFILFSSYSPHVSAISLSSYPSYSPYGDTDLPSQSFLPFFSLFQELILSPDLLPMLLNGWVVGICDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0W5</accession>
    <name>A0A317V0W5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_478906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461955.1">
        <property type="nucleotide sequence ID" value="XM_025608717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0W5"/>
    <dbReference type="STRING" id="1450535.A0A317V0W5"/>
    <dbReference type="GeneID" id="37110860"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY67606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="527" mass="58977" checksum="E9B0FFE79D803E6C" modified="2018-10-10" version="1">MTCFLIIRSGKSIGRDELVAYTNGHFLVDEQRQLDRRYMNFDLDALCDVAAAVGDGSSPIITIEKMEGGFSKALLMTKKNGVEVIAKIPCHIAGPASLTTASEVGVLEYVPRVLSWSSDSANPVGAEYIIMEKAAGVPLFQKWADMLEIERLELIKNLTKFEAQLSAIRFPAYGGLYLRAHARDPKYQYQILDGSIDTSNAFCIGPSCDSSFHIEPAADSAQSDISSNQGPWATISQLGISIANREVSRISINRLNGPPMFYRGSVEEQTQLLQSTISLMPMLDSHPSLLQSSQPTLRHTDLHMGNIYVAPDDSTRIVSIIDFQSVSVMPAFLQARWPEFLKPPQNYTEGLIHPKLPNGFDAMDEENKMLARREWSQAKVAKAYEVSTYLEDRPAHNARNVPRVFRELFTRCGEVSEVGVIPLRACLIEIFHNWSGLGFTGSCPFSFTAEDISAHEAQFHDYQAWHEVQRLAQECLDTDAEGWVAPQVNFAEKRRQNSELLAMFIDRMADEKSPEEARKMWPFPDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V1T6</accession>
    <name>A0A317V1T6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_611925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY68035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462084.1">
        <property type="nucleotide sequence ID" value="XM_025616654.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317V1T6"/>
    <dbReference type="GeneID" id="37118797"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="368"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="1266"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="1626"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1266"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="4">
        <location>
            <begin position="1425"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1585"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1701"/>
            <end position="1721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1590"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1608"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="4">
        <location>
            <position position="1298"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="4">
        <location>
            <position position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY68035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1990" mass="216757" checksum="6FC873F141BA8A6E" modified="2018-10-10" version="1">MEIFVFGDQSTDSFSSLRSRDALARPIAQDFLVQVNAALRREIGRLSSWDRQRVPALGMQANALQDWLPRATTDPVLRPVLTVAAQIVEFICPTHRITLGSCTGLLVGAATATTASWSLTRWLPLAVHIVVIAFRLGLHTAAVGETLTGTDAGGPQKSWSSVVQATLDPPVLADYHTAAPSTSTDLEKNVPIPLQAYISARAPLSTTISGPPAILQGLFSSPGFHATGCSPRPLPIFAPYHGPHLHQDADLDWITALDEHAGRQTVGSYTPSGTLISSRNASPFKNKDMAGLLREVVQEILSDTLRWDFVTWQMVKMVPIDARVGITVFGASPLGESIASSLRATGKRRVSLDPAMHIPSVQERPSPMQKIAIVGMSGRFPDADTIGELWDILFQGLDVYTTVPSDRFDISTHVDPTGKKENTSTTPYGCFVKNPGLFDPSFFSMSPREALVTDPMQRLALMTAYEALEMSGFVANRTPSSMLDRVGTFYGQALDDYREVNAAQNIDPFYVTGGVRPFGPGRIHYHYKFTGPSYSIDTACSSSLAAIHLACSSLRSKECDMAVAGGTNIITGSDMYAGLSRGHFLSPSGSCKTLDEDADGYCRADAVGTVVLKRLEDAEADNDPILGVILASGTNHSALASSITQPHGPTQRLLYRSVLTDAGVSPSAIDYVEMHGTGTQIGDSTEMGSVAQVFGDESRPEPLYVGSIKANVGHGESAAGVTAVIKGLLMFRKNLIPPHVGVKNRLNQRFPPLDEKQIHIPGRNIAFAPRTHRRRRILVNNFGAAGGNTALLLEEPPVKTNPPLTGHRVVYPIAVSGKTPTSLVRNKKRLVDFLSRNTDTSLADLSYTTTSRRRHYRHRFIAVASTVGDVQTALAGPAGECHAEEPTLIFAFTGQGSIYTGVAQHLFNACRSFRTDIVRFDSLAQAHGQPSFLGLWDPTVNRDTLSAIQTQVGQVCIQMGLYHLYRSWGVTPQAVIGHSLGEYAALYATGVLSANDTIFAVGRRAEIMERYCTPGSHRMLGVGAPLSTVQDVIKGTQAEVACINGPRNVVLAGPAGDIEAASSVLSNKGIKCISLPVPFACHSAQLDPVIEPFEMVAEKLEFHAPRIPLLSPLLGVEIRETGVLNARYLARHLRETVDFVTALESSTLVTTGSDVQFVELGPHPLCCYMIRNVLGKTAIPSLRMNVNSWKAVSESVASLYMKGVDIAWEQYNRDTAPSSICLSTLPAYAFDERNYWIDYQNDWALTKGRVPLAASIPCGPATTSVQRLVREALEADPPIVEFESDLNHQGFSEVITGHAINQVGLCPASLFVDMALTAGKYLYEHTVAREGLDVLGLDVADMEMVSPLVHRADAEQRPGVVRITATLNEDAVDVHFSNSRQTGVARAVYAKCRVVRQDVAKVGRQWQRNKHLLSSRIADLQSMSHVHRLHRGMVYKLFGAVVNYSEHFHGIDEVWMESTHYEIVARISPKNSQSGQNSFCNPYWIDSVLQPAGFVLNANGTVNTSKVVYICNGWESVHVAAELSSQHEYTIYVKMEPGEGTAMVGDLYILHRQEIIGVGLGIRFQALPRPLLQLLLGPSHRSPYPEPVLSSSAQASKSISHSSEHQSTPPASECQSVADQHHRADQSTPDLVRRILCEELGISSADLDPNAILTDLGVDSLMSLTILGRLREFCSLDIPPTFLAGSRTIAQLFQTLDGQSVQKTAPTKPLTQTPTTSNPSHRATSILLQGKVHTTTRRLFLFPGGFGSSATFATMPSIHPSLAVFGLNSPFTHCAEDFTIGIPELAALYLVEIRRRQPHGPYSFLGYSVGGIIAYEACRQLVIEGETVDRLYLVDSPCPLAIPPMPPKLIQFLDSIDRFGGTSKEGEHREPVRPMGSLHITQTLVSLEPYMPAPLPIHSCSTRTTLYVAKHGVNQQSGVQVPDFSERDRRVVTWLLEDRTELGAMGAGWETLVDPARLTILPVNGNHFNMMREPHVREWVDELRASYFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3M6</accession>
    <name>A0A317V3M6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_329660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000050">
        <property type="protein sequence ID" value="PWY66790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461726.1">
        <property type="nucleotide sequence ID" value="XM_025606966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3M6"/>
    <dbReference type="GeneID" id="37109109"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="56"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY66790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="475" mass="50964" checksum="56D3961FC3C86DD7" modified="2018-10-10" version="1">MADKIEVELSDRGGPMIERDARGSLPKDDESSPSKNNDPVPEPVYSQWHYVSVVAAGFVVMITTCAFVFSFGVYQSLYEEMAREPNTPFTGSTTALIDLIGTLAIALMSMAGPFAMSWAKLFSPQAVIIAGGWVFGIAYILASFSKELWHFALTQGLLLGIGTCMAYVPTMAVAPTWFSKRRGLAMGVIISGTGVGGMIWPPALRAMISHVGFRNALRISGCISLTTVTAAGAILRWEPKFHEQVKLQAAGSSTRSKPKWTRLFSVPLVNWRVARSKRFVAQALGCFLQSAGYSTPLFFYAAYAQALGYSATTAANFITLSNASNFVSRIVIGYAADKLGRINALAVTTMLSAVAVFAFWLPSSLVSSAAAHGLFIVFTILYGAFASAYISLFPASLVELFGVQHFTSVNGALYLVRGIGALLGTPLTGLLIPRGTALTESGTYERAAITVGVLLFAATVASFWVRAEVRGKWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V484</accession>
    <name>A0A317V484_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">General amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_570001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461961.1">
        <property type="nucleotide sequence ID" value="XM_025614770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V484"/>
    <dbReference type="STRING" id="1450535.A0A317V484"/>
    <dbReference type="GeneID" id="37116913"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="654"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="699"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="728"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="776"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="804"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="30"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY67612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="864" mass="95651" checksum="34C5D70F27EE2321" modified="2018-10-10" version="1">MNSPPSTVEKRLLATAEHLVGRNRAPWVHPNLEQGVVPVKGRQLRASQAIRKGELLLVDVPYAVIPVVDDPASSDGLLCSNPACSRQTQCGSGRIACPKRCIADVVWCSSACQELDEARHGFECTWLQRYAGPVRAKWGEYDFGMLWLIVRILASRQEELQHGGGHVNETSPRFQGGWDSIQEFCGSTESWSHAQIRSWTALVKKYLRSGPVLPHDLTADEIVALICREEANSFGLYPRETGVFPVPEPSVDRGDQYGAAVYPRAAIANHSCCPNIMHKPDHQGRMVFTASRDIAAGEECCISYFDLTKRVELKERRDHLQGLFRTGASTAEVSDHESQSQSQASPIMASGSQHLHRKLRGKEVQLFAVGGAIGTSLFVQMGAVLPKGGPAGLFLGFVAYGTIILAVNQCFAEMVCYLPIPSPFVRLAGHWVDDALSFAMGWNFFFTMALGIPYEIVALNVLLTYWTDRVPVAAVVVIVMVLYAILNTLTVRYFGVSEFYLSFFKIILMLGLILYTFITMVGGNPDHDAYGFRYWNDPGAFVSYIVPGSVGRFCGVLVCMVQASFTMVGPEYISMAAAEAERPRRVMRKAYSSFVWRLMLFFILGALCIGIVIPYNDPILAATLAGTRKGSGTGAASPYVISMTHFNIPILPSIINFLIMTSVFSAGNNLVFSAARTLHGMALTGKAPHFFSHCNRHGLPYNAILFSLSFCCLAFLQVNTSSATVLTWLVGVITASYLLNYLGTCITYLHFYSALRVQNIPRDMLPYKGYFQPYAAWYAVFGTGIMTLILGFELFIHGEWDTTTFFLDYTMVGFFVLAGVGWKVFRGTRYVWPREADLGVGGLRDEIDEGKREGWRGVWDGLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4W7</accession>
    <name>A0A317V4W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_628615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462341.1">
        <property type="nucleotide sequence ID" value="XM_025617495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4W7"/>
    <dbReference type="STRING" id="1450535.A0A317V4W7"/>
    <dbReference type="GeneID" id="37119638"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY69026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="291" mass="31284" checksum="1241D1C8C0CAAC92" modified="2018-10-10" version="1">MEPERKVPPIPWMRLGDPNPESSLTPPPAPFPASNTAADNARQRFAVTGNAPSPQRGLSSNTASEGLALLDLPTSLTKSKDQILSLEHDFPSAKILSIPCNVTLETVVQSAIETASTHLGNLKILCCFAGIVNCVPSIEMSLADYQKMQDVNTTGAWIAAQTIAKKMIHTHTRGKILFISSISGHRVNYPQPQLAYNISKAGLLHMKNCLAAEWAQYGIQVNSISPGYMDTVLNEGEGLVEHRGVWADRNPMRRMGQPNELTGPVVLLCSDVGGSYLNGVDVVVDGGGLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V685</accession>
    <name>A0A317V685_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_551053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462221.1">
        <property type="nucleotide sequence ID" value="XM_025613524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V685"/>
    <dbReference type="GeneID" id="37115667"/>
    <dbReference type="OrthoDB" id="10338386at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="311" mass="34356" checksum="9D70A60F7275D72E" modified="2018-10-10" version="1">MTLTDGARPPHERKSDETQSGQAAWDWRAVNKEGGGGPVVTRSQDGGRWTIDSGLALVRNNPDDIRPTRNRQVGSFLLFDGATGGQWRVCSRVGTIITNMNHHLDSSLTPTQNGLTACDNDVSLIPSAEPGRLCVMCLCLSVSVDDPAWPELVSSKSLESPLAFPFGSARGSKIGRNMPMIAGHSDSVVCFFLVLLLVSASRSRVKPPTAVVVARRRATEKSRIVEKRERERIRKINEGHHPHAAKKSPFTRDMGNSEEKGKISLREAYRVRTDDGRRPQDFRFMEEAMRPVKQDQGQRTFDQVATAPGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9L3</accession>
    <name>A0A317V9L3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_502019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462848.1">
        <property type="nucleotide sequence ID" value="XM_025609445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9L3"/>
    <dbReference type="STRING" id="1450535.A0A317V9L3"/>
    <dbReference type="GeneID" id="37111588"/>
    <dbReference type="OrthoDB" id="4192742at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY71093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="314" mass="35949" checksum="D2F5F4A9C9FF1C86" modified="2018-10-10" version="1">MLHANLPVAPKRSAPSSLVCESETTPSSTGSTDNSVSQRFYRSLECENRPETAEFPDHTLAESAAVRRQLLLEDTRRTALHTLSLCRNVIASLEITRLSKSRTGLHYWLGFWDQIYDRPFSRVLSSRVTSALARIDALFRAVSGDLHQLTRRMQHVVTYATTERDILHYLERMEDEVSARRRRRRKKAQAILNKLRATIESIPVKVTDELFDDLKRGVFALDVFCDYHPGDPVAEEHEREALRPTRIVEVSPYVPRTQPWNESAAAGAYMPSSSAYTDINTDWSEYVGDWAHTEHDSRSHNHHAHHAHHAAHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VC63</accession>
    <name>A0A317VC63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_266884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462725.1">
        <property type="nucleotide sequence ID" value="XM_025606530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VC63"/>
    <dbReference type="GeneID" id="37108673"/>
    <dbReference type="OrthoDB" id="10542020at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14772" checksum="3F29B869B1AE960A" modified="2018-10-10" version="1">MMETISSHLCNPFDRNHSNQTMELEETFTKCLGVSILAVIGLIFLPPMAGICDGRGLLGQLGSTIIELYPILGRFVLQFLLVMFFVFPLVMVFFMALSLLISFILFHYDRALGRGIGRAIREDVDYRDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VEI4</accession>
    <name>A0A317VEI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_560553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462581.1">
        <property type="nucleotide sequence ID" value="XM_025614162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VEI4"/>
    <dbReference type="STRING" id="1450535.A0A317VEI4"/>
    <dbReference type="GeneID" id="37116305"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF2">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE AUSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="68"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY70290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="619" mass="69041" checksum="FA16FFD2C2B9DCF5" modified="2018-10-10" version="1">MPHTDANRRYTQLSVPRKDPPGGVPSENNARIDDHGAEKVSRPPPPLTAGYTTYQPHPTTPLPTTTPILIIGAGWAGIQCAIRLLERDIPATDIRIVDSASDFGGTWYWNRYPGLTCDIESYSYLPYLEETGYVPSKRYATGEEIRGYVDVVVRRWGLGRCGVFGTKVERARWDEAGREWVVGMVRGEEKVEGEVRARFVVVAAGVLNWPKLPDVDGLGEYMGEVFHAARWRYEEKGLEGLKGKRVVVVGTGATAVQIVPVLARWCERLVVVQRTAASVAVRDQRVTDEEWFWREVAGSKGWQRERIRNFHQQFTLGEKPAVDLVDDGWTHSRGLVGLTGDVGGPMLPEEIPAYQERLIEMDAPRQAGIHARVDREVEDPDTAERLKPWYPVWCKRPLFHDEYLKTFNRENVTLVDTDGKGIERMTTDSVVIGGKSYQADVVIFATGYLAPPAGTPAEKANMSIIGLNGVSMSEEWSRVGPTTLHGVIDAKFPNLFLSSPEQAATSGNYRFSLDEYAKHIAYILTESMRRADGERFVVAPSMEAAEDWALQVMMRSAPMGVVLGCTPGYLNLEGDLDRLSPEKQMVLARSGIWGWGIEHWLGVIEDWRAEGSMKGIVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFF9</accession>
    <name>A0A317VFF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_607607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463389.1">
        <property type="nucleotide sequence ID" value="XM_025616542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFF9"/>
    <dbReference type="STRING" id="1450535.A0A317VFF9"/>
    <dbReference type="GeneID" id="37118685"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="641"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="749" mass="82481" checksum="E0E3DBE59944A48A" modified="2018-10-10" version="1">MYNAILPGLDHPGTTYFYYHLGYTNSSECMPSGWSLNSYFSPGRCPSGYTVATTAVSITNDTRTETWADCCPTGYSYDKAWGLGERCTSTAPQLATSTSNPTQRNQGLVAANAVSVKWSAEDFSTSSTDSQSRHDSLSVTAKASIGISVTFGFFIVIVLAFTVYHLCRGQKQQPGVTYNQSATRRKRRDCCLRVVTLLVIGLSGARWGPIRGYTNQLPNRLHLAVGECIGQLRWITLRQSRKPLSYIQLYDSASRGPWGSFRILLQDEFRSLVTVGACVVILALAFDPFIQQIISYPVQPTQRYSKEAVVTQSRYIIAVFQRGLWPDPVSLDPSCPTGNCTWPHYRSVEMCNQCANVNPSRVLLAGWDFSSFNYSLHGNQAIPARISMVDGQWSDFLIEIIWRKVGFYRAYIPSNLYFLDGPNITYDSDTKFVAGISNPLAVVTHVELNLPVTWKSNDDLLRAIGVAKVTQCAFTVCAKTYNVSVTNGVASVQTLDEDMGSFYPPDYLSNLATSVCWKPNSSPMTNWTTAGQREGSYAKTDPANYEFCGLDSVRYWDSLPLSGTVSPEYELETSLNGSMIWQPLVINPYPSSASVQKVYEMGLATTMDKIGAALSKLARTYSNNSIYGVVITQDSYVAVKWPWLALPAVLLVAGTVFLIATALITSHDGASLWKSSVLPLLFHGPEPNLVTRDMVVEHGPCEVASEMEQAAGEVNVGLGVSEEGGRTMLQGERRSAEPTVGQLLRRQTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFN4</accession>
    <name>A0A317VFN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Drug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_525898</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463014.1">
        <property type="nucleotide sequence ID" value="XM_025610330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFN4"/>
    <dbReference type="GeneID" id="37112473"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF36">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="30"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY71778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="515" mass="56091" checksum="0611E5FC420E6CE8" modified="2018-10-10" version="1">MGDPYSAAELERLGRMRPAIFPSLASELGFCFSLVLSQIMAEYFISGFNVLLPSLAEGLDIPEASSSWPSSAFALTAGASLLFFGRLADRYGGFVVFAGGLAWHLLWSLVAGFAKNALTMYFCRALQGFGPAAFLSAGIMLLGSTYRPGWRKNLIFSIYGACAPIGFVAGIFVSGMTGEFLDWRWYFWIGAMLLFLALVTVVISVPTSIRHKPPHPDIAMDWAGAILFFCSLILIFFAINECGHAPDGWRTPYVYITLIVGSLILMGAIYIEGWVASEPLLPLSLFRIPQMASLCLGLFCFYGVFGIWLLYCVEYMENIMQASPLLVVAYFVPFALGGIFFSLLGGLFLHIIPGTVLLVISGIGWLIAPLLFAIMPHDAGYWPYVFPAMICGTLGMDVTYNVTNVFVTTCLPERQQGLAAAVANSVLFLGISFWLGWGDFTSAQVSGSLRARYQAALWLAVALAGLGLIIMVLFVKIKPAKSEITVDEKDSGDSRVVLDKDADVRDDERAESSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFP0</accession>
    <name>A0A317VFP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tachykinin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_560242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463024.1">
        <property type="nucleotide sequence ID" value="XM_025614134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFP0"/>
    <dbReference type="STRING" id="1450535.A0A317VFP0"/>
    <dbReference type="GeneID" id="37116277"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY71788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56238" checksum="7127ACA35AA89220" modified="2018-10-10" version="1">MPPVRQASQDTDTPAPDSASSSTPHEASRFTFVLDGHQASTRSHAMRVHWTERHRARREKRQQQASRQPYPTLAAKAALPIRQPSQSSTSSHHNPAPRRIQPRPFHRPLDPFDSFPIRLTTQHHKLIHHWLTTHATMMFETIPAPSFNPMRDVWFPLDLSNPASFNAIMAHSAAHLAHYYGATTPTQGTNSIEALRFKADAVKILSQWLSDPDKALSNDAFAAVVRLLTFERYWGTEEEWKVHRSGLQRMIHARGGLHQLHSDWRLELVVGLVSLMSKPSWFESTNDLSEISDHRIATQSILGSSIDLHKIRCLWLISFIQDMRNLMGMWSRLYLDGLLGFPSLYDAILLVRGDFEHEAEHSHSAYQPSDYDRLTCLFAICILVQGSVSQAYSGPHNALTVLDMALETCRSAWESSVYLLHAFLHDHFVDVFPNGARTFAYVTQMTDVVSHLSLEAHQGIEKCLLNMLCRTRRSKLPFYVDDGGTPDSLLSTVHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGD9</accession>
    <name>A0A317VGD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acyl-tRNA synthetase complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_539345</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463174.1">
        <property type="nucleotide sequence ID" value="XM_025612687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGD9"/>
    <dbReference type="STRING" id="1450535.A0A317VGD9"/>
    <dbReference type="GeneID" id="37114830"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10304">
        <property type="entry name" value="GST_C_Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000199">
        <property type="entry name" value="tRNA-aminoacylation cofactor ARC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="TRNA-binding" evidence="5">
        <location>
            <begin position="246"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY72221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="446" mass="47338" checksum="C06DD42F6EC9E50B" modified="2018-10-10" version="1">MAINSAPESSLLSLLYRSYPNAVSPDATEPDLQTATPKIFPQTSFSVAEEADIKQWLATISGLQTALTKDDKPVVSTILSQVNTHLTTRTTLLGAKPSVADIAVYALVAPLVEKWTPEERTGEQGYHHVVRHVDLVQNSRLFALQIPEEEKVSIDVNDVRFVPKPVDPKEEKERKKKEKAAAAGQTPDAGKPLVVGQGKPEAAAKKGEAKDAAAAAAKPEGKPKKEKKEKKEKPAKAAPAPAAPPSPSVIDLRVGHILRAINHPNADSLYVSTIDCGDAPGSENTSLDEATGKTVRTVCSGLNGLVPLGEMQGRKIVAVCNLKPVTMRGIKSCAMVLAASPRVAEGEDSHAGPVELVSPPADAPAGERICFDGWTEGEPEKVLNPKKKVWETYQPGFTTTDDLEVAFEMSAVPAVQGQEGKPSLGKLKTLSGGICTVKSLKGATVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHC9</accession>
    <name>A0A317VHC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polarized growth protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_538809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463518.1">
        <property type="nucleotide sequence ID" value="XM_025612567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHC9"/>
    <dbReference type="STRING" id="1450535.A0A317VHC9"/>
    <dbReference type="GeneID" id="37114710"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY73766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="62533" checksum="AE273BA09AD41603" modified="2018-10-10" version="1">MFLRLLLRRVLAVLVPLALTSTLYLYLYPLFHGCAFPLPDDSPSPIPLLSIPHLSPSFLTTLRGHLSPSLSSASPSDSPIFRLLVLADPQLEGDSSLPKPHEQLPARLSNYYADLRSSLRTKPPSATLSTLRSVLRSLVHDDVPRAFRAARKRLDLLGNDYYLAHIYRTLHWWSVPTHVTVLGDLIGSQWVSEGEFEARGERFWERVFRGGKRVEDHISHGMGVEVLGEDGGWDKRVVNVVGNHDVGYAGDVSRGRIERFERVFGKGEWDVKFRLPSSSSLSVNGEEGEEKEGESPTIHLINLNSLILDTPALDPDIQATAYEYLNGLLDQRSPPVTGDRNRTFTLLLTHLPLHKKEGVCTDAPYFAFHEEDDSQDEPRFYESGLKEQNHLSEYVSANAVLEGVFGMSGDESVPGGGWGRNGLILTGHDHTGCDVVHFVNRTVGEESEWGWDAVGYGDLESNKEKSMGVPAIREVTMRSMMGEYGGYAGLLSVWFDGEWQYRIQMCAAGVQHVWWAVHVLDVVTAVLVLIFLCGSGQASSVVSAGKDTQARRKTKEKEKKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIB0</accession>
    <name>A0A317VIB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_260394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462968.1">
        <property type="nucleotide sequence ID" value="XM_025606486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIB0"/>
    <dbReference type="STRING" id="1450535.A0A317VIB0"/>
    <dbReference type="GeneID" id="37108629"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="312"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY71570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="671" mass="74161" checksum="E43E67F0F896CD3C" modified="2018-10-10" version="1">MESPKPPTNGASSVDSRICQNGSQASMTSEIRPSWRPYRGRWRSKKANRRGTDELDATTPESSTAPSARLRRPRRNKQSAERRNQEETNIQASQPTNTGSYTQGNPAQNGLMNFDNFNPAPMFSGVSAGMAMPNENGPVFQQPFLQFPWDQQQFLPQYPPGQPAHNPFGLPTWNDQGTYAGQFPPMPPPAFMNFALTNPLMAIPFLGPMAFQAAGSAEVSSQLPGSPSTKQCIGDSESWASPEGAPNAVSDWQPRDLRREAAREYRGKVRTGKTEYPGQPRSKSPEVTVQLKRPMPTKAYLDQSSQPPKRNSWSQPLLIILDLNGTLVHRKDRSLPPRIRKRAGLEDFIKTLMQKYKVMVWSSARPPTVDGVCRQLFLNKSRTRLVAEWSRDHFNLPKKQYNAKIQVYKTLGTVWADEGIQASYPGLRDLKAPVPDTFEKARWDQTNTILIDDTIFKASSEPHNLLEIPTFDESAGPEDATTLAKVLRVLEELAKHDDVSQALHHWQPPIPNGGSILDLDIEHDDGRPHGPPTLAEVTEARKQRRKARKREKAAENRRARQNKKLEERYAAKVKEPPTTMPTAIISAESATAGADTTPVHPSSSSSPPPSPASSISFPDSTAGGATIPTAQGKANAATHVSDSTNRSPSPAPSTQSENFLLDRLEESLKNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJE4</accession>
    <name>A0A317VJE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_227517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463677.1">
        <property type="nucleotide sequence ID" value="XM_025606276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJE4"/>
    <dbReference type="GeneID" id="37108419"/>
    <dbReference type="OrthoDB" id="4506934at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY74484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="135" mass="15034" checksum="39843595D27BA0D6" modified="2018-10-10" version="1">MGHPAPSPSDEPTPPYEESPNTNNHHHHLPHQVRPHQALPNTSYPETPNITHQNIIIQYIELPQTDLETGPNHSSNSNSNPHDHCAACERIIARQERRHAQMHCCRMVAVVFIVLLICLMVLGIVIARAAAGGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJX2</accession>
    <name>A0A317VJX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPT2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_627420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463779.1">
        <property type="nucleotide sequence ID" value="XM_025617422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJX2"/>
    <dbReference type="STRING" id="1450535.A0A317VJX2"/>
    <dbReference type="GeneID" id="37119565"/>
    <dbReference type="OrthoDB" id="5430658at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY74586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="38217" checksum="0236746EF5DF8782" modified="2018-10-10" version="1">MSFLDSVLSSIETGKPSPIPSTSSLPTPPVSGPSTRPPARRPIHVRRDGAPERKPIDTGTKRKAEEQLARPAKPVPPAPARTTATTTMRPAVSTAPRPRSSAQITSTSTTSTIKSRSSTPQKAPPVSSKPPPKGSFADLMAKAKQLQQKAPTQVGMFKHQAAPKEKVSKVERKKKAAETSSKEKDARSAKKPGVITGHAGAHETATKTKPGDSKVVKKRESEPLSYKGTARPTPNSNPTPSSNQNEYRGTSGLPPRKNPAEWKAQSRASKRSRMDEYLGTDEEDEGEYADDYDDYFSESSDMEAGLDAMEEEEAAALAAARREDEEEWRAELAAKQQKLDRRKKLTALAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKQ8</accession>
    <name>A0A317VKQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GABA transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_227234</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463668.1">
        <property type="nucleotide sequence ID" value="XM_025606274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKQ8"/>
    <dbReference type="STRING" id="1450535.A0A317VKQ8"/>
    <dbReference type="GeneID" id="37108417"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF1">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY74475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="533" mass="57691" checksum="87E9169A9B342A00" modified="2018-10-10" version="1">MQESVELRDRQWNSKAAQSSHSQVNDEQGLGRVGKKQVLKRRFGFLSILGFSCTVLASWEGILSTFTVPFEDGGPAGTVYSFLVVWVGTFSTFLTLSELVSMAPTSGGQYHWVSMMSPRWCQKYLSFLTGWLIVIGWLGAFASTCYLSASQIQGLVVLNNSSYDPKPWQTLLLFWAIVAFAVFVNVVTSTMLPKFEGLVLILHVCGFFAIIIPMVYLGDHNPASEVFGQFANDGGFPTQGLAFMVGMIGNMFAFTGVDAAVHMSEEIYNAERVVPQSILTSVLINGLLGFGMILSTLFTMTDAETALGSPTGYPYMQIFCSSTSSLGGCTVMSAIVPILVTATAVGSLASSSRMAWSFARDRGLPGWRLLSRVNAQAVPQYSILVVTIAAVLLALIILGSAAVLNDVISLCVSALYASYLISAFLLMWKRCTGGIREPSDTPIDSVVNTAGAPLAWGPFHLRGVLGLSVNAFTVAYLTIGVFFSFWPDEMNPTASTMNWAVVGTAGTSLVSTLYYIIWARKEYTGPVVDFDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLK8</accession>
    <name>A0A317VLK8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_627268</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463881.1">
        <property type="nucleotide sequence ID" value="XM_025617406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLK8"/>
    <dbReference type="STRING" id="1450535.A0A317VLK8"/>
    <dbReference type="GeneID" id="37119549"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016234636" description="beta-galactosidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="11">
        <location>
            <begin position="379"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY75254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1159" mass="127699" checksum="5A82704DB5ADC5A9" modified="2018-10-10" version="1">MKLQFLLSCWAIFVAQIRATTDGLTDLVAWDPYSLTVNGNRLFVYSGEFHYPRLPVPEMWLDVFQKMRAHGLNAASLYFFWDYHSPINGTYDFETGAHNIQRLFDYAKDAGIYIIARAGPYCNAEFNGGGLALYLSDGSGGKLRTSDATYHQAWAPWIEHIGKIIAANSITNGGPVILNQIENELQETTHSATNTLVEYMEQIEEAFRAVGVDVPFSSNEKGQRSRSWSTDYEDVGGAVNVYGLDSYPGGTSCTNPSTGFTVVRNYYQWFQNTSFTQPEYFPEFEGGWYSPWGADAFYDQCTSELSPQFADLYYKNNIGQRVTLQNLYMLYGGTNWGHLAAPVVYTSYDYSAPLSETRQIRDKLSQTKLIGLFTRVSSGLLGVEMEGNGTSYTSTTSAYTWVLRNPNTTAGFYVVQQATTSSQTDLTFSLDVTTSAGAFTLPNINLEGRQSKIITTDYPLGHSTLLYVSTDIATYGTFGDTDVVVLYARVGQTASFAFKNATKLTFEEYGVPVNLTSNSGNRTTTYTYTQGSGTSVVKFSNGAIFYLLETETAFRFWAAPTTTDPYVTAEQQIFVLGPYLVRSASLSGGVVELIGDNDNATIVEVFAGSSATAVTWNGKEVAVNKTEYGSLVGSISGADSTIDLPTLTGWKVRDSLPELQSSYDDSKWTVCNKTTTLSPVDPLSLPVLFASDYSYYTGIKIYRGRFDGTNVTGANLTAQGGVAFGWNVWLNGDLVATFEGDASETSSTADLGFSNQTLKETNNLLTVVIDYTGHDETSTADGVENPRGLLGATLKGGTFTSWKIQGNAGGAAGAYELDPVRAPMNEGGLLAERQGWHLPGYQTNESDGWTDGSPLDGLNKSGVAFYLTTFTLDFPEDYDVPVGVQFTSPSTVKPVRIQLFVNGYQYGKYVPVLGPQTTFPIPPGIINNRAENTIGLSLWAQTDAGAYLENIELVSYVNNLDKKQLSEIVSKAIEKHPDVRAMLEETTETIRRQESNRVIHFDSESRSGWRDLNVTYQRLSGSKQYDVAGEVEEIIAAIENITSQCGSCANPQTRYNGLSMLSRIGKSIALSHGQVACKVRKRFQWDRIMEDSMIRIVNAMDIQERLDIFRDISTPDALWPKLLELFRVAESYCVFKKLRDVLYLIRGKEDPEGSADPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPR0</accession>
    <name>A0A317VPR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_559194</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464156.1">
        <property type="nucleotide sequence ID" value="XM_025614050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPR0"/>
    <dbReference type="STRING" id="1450535.A0A317VPR0"/>
    <dbReference type="GeneID" id="37116193"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000044">
        <property type="entry name" value="Probable proteasome subunit alpha type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY76343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="297" mass="31647" checksum="5CC7C2B21F4D40F1" modified="2018-10-10" version="1">MTSIGTGYDLSNSVFSPDGRNFQVEYAVKAVENGGTAIGIRCKDGVVLAVEKIITSKLLKPGANKRIATVDRHVGIASAGLVPDGRHFVSRARDEASSWRGVYKGPIPISALSNRLGSYVQAYTLYSSVRPFGVTAIVGGWDSEAELAVDGQVGSGPKSGSGGKVEGAKTGGPGLYMIEPSGLYWGYYGAATGKGRQAAKAELEKLDLSSGTLSLVDGVKEAARIIYVAHEDSKDKEFELEMTWISSLDGPTKGRHEEVPKDLLEEAERAAKRALEGEDEEEDATKGNSNETERMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPU4</accession>
    <name>A0A317VPU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_538245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464196.1">
        <property type="nucleotide sequence ID" value="XM_025612449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPU4"/>
    <dbReference type="STRING" id="1450535.A0A317VPU4"/>
    <dbReference type="GeneID" id="37114592"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY76383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="467" mass="50987" checksum="441EEDA3AB15B2F5" modified="2018-10-10" version="1">MGLFLFLKKRSGFRVDNSRTTSAATLTLRQSLWPLTLVTILFFLWGFAYGLLDTLNKHFQNTLNITRTRSSGLQAAYFGAYPLASLGYANYILRHFGYKTAFIFGLTLYGIGALCMWPAGLNRSFGGFCAATFVIGSGLGSLETAANPYLTVCGPPKYAEIRINLAQAFNGIGTCVAPALASYVFFTSTEDDVNALKRVQWVYLAIGIFVFILAGVFFVSTIPEVTDEDMAFQVAETHVGEQEKPFWKQYKLFHATLAQFTYTGAQVAIAGYFINYVVDTWPGTTSATGSKYLAGAQGAFAVGRFLGAIIMKFVKARWVFLVYLSCTVAFIAASITQHEGNGIAMLFCTLFFESVCFPTIVALGIRGLGRHYKRGSGFIVGGVSGGAVVPPILGHVADMRNSTRFAMIVPTMFMVVAWTYAIAVNFVPAYLDMVDKVGSSDIGLQEDDVTSKNVESDGKVSREQRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQV5</accession>
    <name>A0A317VQV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_559196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464158.1">
        <property type="nucleotide sequence ID" value="XM_025614051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQV5"/>
    <dbReference type="STRING" id="1450535.A0A317VQV5"/>
    <dbReference type="GeneID" id="37116194"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="51"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY76345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="386" mass="42209" checksum="7918F470482881BC" modified="2018-10-10" version="1">MFSLRTAQPAQSFLRRVAAPTSFVRSSIPARSFASVQSDIFKPTKYGGKYTVTLIPGDGIGAEVAESVKTIFKADNVPIEWEQVDVSGVDTGNKHSEELFKESIASLRRNKLGLKGILFTPVERSGHQSFNVALRQELDIFASIVLIKNIPGYKTRHENVDLCIIRENTEGEYSGLEHQSVQGVVESLKIITRAKSERIAKFAFGFALANNRKKVTCIHKANIMKLADGLFRSTFHKVAENYPTLEVNDMIVDNASMQAVSRPQQFDVMVMPNLYGGILSNIGSALVGGPGVVPGCNMGRDVAVFEPGCRHVGLDIKGKDQANPSAMILSGSMLLRHLGLDDHANRISKAVYDVIGEGNMRTRDMGGQATTHEFTRAVLDKMEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSD3</accession>
    <name>A0A317VSD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_577621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464481.1">
        <property type="nucleotide sequence ID" value="XM_025615181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSD3"/>
    <dbReference type="STRING" id="1450535.A0A317VSD3"/>
    <dbReference type="GeneID" id="37117324"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014390">
        <property type="entry name" value="Acid_Pase_Asper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000900">
        <property type="entry name" value="Acid_Ptase_Asper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016188984" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="20"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="8">
        <location>
            <begin position="71"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="275"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="7">
        <location>
            <begin position="533"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY77294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="609" mass="67066" checksum="7997A218E841707E" modified="2018-10-10" version="1">MKGTASVLLVALSATAVQARPVVDERYPYTGPAVPVGDWVDPTINGNGKGFPRLVEPPAVKPATANPRNNVNVISHSYLPTGMHIHYQTPFGLGKLPAVKWGKNPQNLNNTALGYSHTYDRTPSCSEIKAVTQCSQFFHEVGLNDLEPDTTYYYQIPAANGTTQSDVLSFKTSRPAGHPGSFSVAVLNDMGYTNAKGTHKQLQKAAHEGTAFAWHGGDISYADDWYSGILPCADDWPVCYNGTSSSLPGGGPLPDDYKKPLPAGEIPDQGGPQGGDMSVLYESNWDLWQNWLNNVTLKLPYMVLPGNHEASCAEFDGPGNVLTAYLNNDVSNGTAPTDNLTYYSCPPSQRNFTAYQHRFRMPGPETGGVGNFWYSFDYGLAHFVSIDGETDFANSPEWNFQEDVKGNETLPTESETYVTDSGPFGKVNGSVHDTKAYEQWHWLKQDLAKVDRSKTPWVFVMSHRPMYSSAYSSYQLHVREAFEGLLLQYGVDAYFSGHIHWYERLWPLGRNGTIDTAAIVNNNTYYAHNHKSVTHIINGMAGNIESHSEFSDGQGLTNITALLDKVHYGFSKLTIYNETAVKWELIRGKDGGVGDELTLLKPRAGANLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VT87</accession>
    <name>A0A317VT87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bicyclomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_568553</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464149.1">
        <property type="nucleotide sequence ID" value="XM_025614688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VT87"/>
    <dbReference type="STRING" id="1450535.A0A317VT87"/>
    <dbReference type="GeneID" id="37116831"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF49">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY76152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="472" mass="50910" checksum="4266029EBB196A11" modified="2018-10-10" version="1">MSNKQLAPHTKYNLEPSPTLKEKVHNTKTPDPAYMVKFEEGDPEDPRNFRSKRKAFLTFQMSMLALVGALGSSILSPGQSAIAEYTNISQEVTVLATSLYVLGWAVGPVLWGPISEVYGRRWGMLPAVFCLGLFSIGTATSKNAASIFITRFIGGIFGSAPISNVGAALSDLYTPKDRGTAMTVLAMCISGGPTVGPIIGSALVTNSKLGWRWTMYIEAICAFALCAFATLMLRETHTPVLLKKKAEKMRRTTGNGRYWHPHANETINLDNASIMASIALYASFTYSLIYLCLQLYPIVFEEERGYSPIISCLPFLGILVGIMSALAINFANQAWYAREMRANGGKAVPEARLPPMLIGGVLLPTGLFWLGWTAAPKYSWALPTVAVQCLNYLVDAYGPYAASAISANTILRSLLAAGLPLAAKPMLHNLGVGPAASLLGGIACLALPIPLLFMKYGPALRRKSKLAQTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW90</accession>
    <name>A0A317VW90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/calcium exchanger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_192132</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464355.1">
        <property type="nucleotide sequence ID" value="XM_025606040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW90"/>
    <dbReference type="STRING" id="1450535.A0A317VW90"/>
    <dbReference type="GeneID" id="37108183"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="816"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="849"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="886"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="933"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="963"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="125"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="822"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="468"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY77168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="985" mass="107308" checksum="83E40F6CE9F2E8B4" modified="2018-10-10" version="1">MYPLLMPDLRRRLAAPQKRSYSARPFWACLLAFSCLAALSWASGRLNHGVTAPLAPSAEQVLLHDVHRLRRDNAVECRLVRQAKDQCSFVLSNCADHEDGLFSYLQFYYCTAANFKPAGFIVIILWLSLLFSTIGIAASDFLCVDLSTLASVLGLSESLTGVTFLAFGNGSPDVFSTFAAMRSNSGSLAIGELLGAASFITSVVAGSMALVRPFKVARRSFVRDVGYFILAVAFSMFLLGDGRLHVWESAMMVALYCFYVVLVVTWHWYLTRQRRVYERNIAARSHFHIPDNQELDIEEEEDDDPGVASEATSLLRGEDFDALERSGVPTWQEGEEDDETRNRYLAEIRDNMHIYRPSTRRRNTLNPIRPSLVGALEFQSVLSSLQRSKNIHHHEPIDLGSCSDDERSHSRSQQSDNASVVSHPCAGRVSAGDRLSPNRAIGSVRTRAVSANAAADLKLDTSMFSSHFQQPRVTVSRPSADTHASVTTGALPPDQGSGSNLSPQSNMRLQSPNLLAPPDAFNSPTYQVTSSRPRSPLSLSPRDTSPSPGPADAFPESSISPFPLFQDAPSGPSPASSKAPSLRLPAAFVPTELLQIHDSVFDSGSNLATTPTWWPTLSLTSQPILPTLFPTLADWKSKTFWERLLGIVAAPSVLLLTITLPVVEPVQLDNGANAVSVIVTSADGENAPSPAVRLPEDSPLLRAFDPESIIQSPVDQNGKTQPGPRHLRFDSELPAIQTNMDSPSPSSKEWCVWLVWTQIFMGPFFVALMYWTTVDSELEARNLLLPSMVSLLFSLICITCLMISTRHNLSSQPPSAWRPVLAFLGFVVAICWIATIATEVVNLLKTLGVILNISDSLLGLTVFAVGNSLGDLVADITVARLGYPVMALSACFGGPMLNILLGIGLGGLYMTLNTKPEAIVRAGGSYEIELSKVLIISGATLLVTLVGLLIVVPLNKWRMDQKIGWGLVILWVISTIGNILAELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWJ4</accession>
    <name>A0A317VWJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464465.1">
        <property type="nucleotide sequence ID" value="XM_025612430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWJ4"/>
    <dbReference type="GeneID" id="37114573"/>
    <dbReference type="OrthoDB" id="5238343at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016282094" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY77278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9196" checksum="A79DE3F59D7F8ECE" modified="2018-10-10" version="1">MKVSAIVTILATTALSVMAAPAADQSANGLMARGDSGCYAFADPDCGVDGTFCQCANGWFYLFNTDEGGCNPPWGIVAKDISGLPGYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYS7</accession>
    <name>A0A317VYS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TOM core complex subunit Tom6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_537902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464629.1">
        <property type="nucleotide sequence ID" value="XM_025612374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYS7"/>
    <dbReference type="GeneID" id="37114517"/>
    <dbReference type="OrthoDB" id="5403997at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020266">
        <property type="entry name" value="Tom6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17112">
        <property type="entry name" value="Tom6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6427" checksum="775B88736D6B1395" modified="2018-10-10" version="1">MVPRQRVVSGRPQKSFFTTAYEEVTHPENATIVRSILIFGAGVAFLHSSLSELLLPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZ23</accession>
    <name>A0A317VZ23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_537985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464690.1">
        <property type="nucleotide sequence ID" value="XM_025612390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZ23"/>
    <dbReference type="STRING" id="1450535.A0A317VZ23"/>
    <dbReference type="GeneID" id="37114533"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="172"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY78178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="605" mass="67300" checksum="CE25A4CF30C174AE" modified="2018-10-10" version="1">MRPESVLRLRGTMRTITPRMSCRFSSQSLSVSQRRGLRVSVQHRADEKPQPFKHQLYESTQQRLKRERAEQERYSQYQTQSQGGRYAALMFALVFFSTGAYYLGSLKPAELPTSSTTSLSDIESPRHNASPSNLQAAWADFVDILGKENVSTQNADLEMHSGSDWSSYALKEDERPFLVLYPSTTEEVSRVMRVCHQRLIPVTPYSGGTSLEGHFAPTRGGVCIDFRRMDRILGLHKRDLDVIVQPAVGWEELNERLSQDGLFFPPDPGPGAMIGGMIGTGCSGTNAYRYGTMRDWVLSLTVVLADGTIIKTRQRPRKSSAGYDLTRLFIGSEGTLGLVTEATLKLTIKPKSQNVAVASFPTIQNAAECVTRVVEEGIPVAGLEILDDVQMKCINDSQSTSRHWKESPTIFFKFTGTPVGVKEQIGMVQKIVSASAGRSFEFARGPDEMQELWSARKQALWSVMSMRRGPEDHVWTTDVAVPMSKLPEIIEATKHDMTESGLLAGICGHVGDGNFHAIILFNQDEKATAEAVVHRMVKRAVELEGTVTGEHGVGIVKRDYLKHELGESTVDAMRRLKLAFDPLCLLNCDKVVRIEPPMTGEVKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W189</accession>
    <name>A0A317W189_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_537287</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465265.1">
        <property type="nucleotide sequence ID" value="XM_025612233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W189"/>
    <dbReference type="STRING" id="1450535.A0A317W189"/>
    <dbReference type="GeneID" id="37114376"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY80406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="93" mass="10729" checksum="F9F4506B6BB44324" modified="2018-10-10" version="1">MTVAESVKSAVGLADSTAASRQEMSDARLPLQYRDSCAHLLIPLNRCRQQEYYLPWKCEDERHSYEKCQYEEFKKRVAKMEELRAAKGGARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1B9</accession>
    <name>A0A317W1B9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Recombination hotspot-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_154648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465132.1">
        <property type="nucleotide sequence ID" value="XM_025605833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1B9"/>
    <dbReference type="STRING" id="1450535.A0A317W1B9"/>
    <dbReference type="GeneID" id="37107976"/>
    <dbReference type="OrthoDB" id="829at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14819">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.200:FF:000002">
        <property type="entry name" value="Putative translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.190:FF:000004">
        <property type="entry name" value="Recombination hotspot-binding protein (Translin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY80273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="235" mass="26482" checksum="D0A3AC64CE7EB8CF" modified="2018-10-10" version="1">MIDHHIFEDLQAKIDDEAAVRDELHDIVQTLARKGRSTQAILSRAHSTPTDQLKPVLDDATKEIIAQRDEVSRLKTVADKHPFYKYNGLWTRELQNLVSSIELCAWLGGLEEYKTNSSASFLTIEEVGKFLGVPVNLKEQDAFHLTIEEYLLALISMVEELARLAVNSVTLGDYTRPVQIGNFIKDLFAGFQLLNLKNDILRKRSDGIKYSVKKVEDVVYDLSLRNLIPKGSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2A7</accession>
    <name>A0A317W2A7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_536986</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465368.1">
        <property type="nucleotide sequence ID" value="XM_025612167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2A7"/>
    <dbReference type="STRING" id="1450535.A0A317W2A7"/>
    <dbReference type="GeneID" id="37114310"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY80766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="674" mass="76514" checksum="322B7F75AF3A0C1A" modified="2018-10-10" version="1">MPHLRRKNGRKPACEACRRRKLACDHETPACQRCRRLSLKCVYLANPLAKARARSAPEGTPDILSGSESDQVATKTCPGAQSTTPILESSAEYLGPTSFASVFVEHRDRFEVDQALRTPTGEDTNEGAQSPAQGNNAITSRLLQLGVQILQNLPDEHTSNLLFGHQTYIMDACFRPAYRVALDLMWDEYRDVLRSRTTENLIGAAKRISEASMTSLPAEQNPRRWVEAFSGRRTRWELLGTLFTYWSSAASQLSVEHESITRYCQRHSVKGPKELMVHLKRCASICLDLCSQLGAINILFVHMAFKHNILESIASGDKSLSCWRQHGDVVAITTSIGLHRELSTDWNEVSFQHELKRRIYASIYNFDKVISTFTGRPPLLTRQYSTTQLPLEISDEDILSNRLSDAVIKLDSNGWDRSEERELYPTTVLRARTMLARNREALLEVLETSQDSITESAVETCLRLKTEAMDIQAQFPEALAFKQEYIDDADIPGQLIFLRILVRLDYLLNLFILERLLTRHKVVSEQALIHVSHEMLDLTLKYWKHKDRFKNHSDFSWLAMSYAVPCSGILCLELLRQATSPSTYMLDLPRSDIIQNLSLLVAFLDWLKPSSSDIIAKGQIKGILRRSLDRILSMPASLCTPTTVDDMVLQNWVGNEYPHLDLLNTFAWVDWDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2D6</accession>
    <name>A0A317W2D6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_471474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464920.1">
        <property type="nucleotide sequence ID" value="XM_025608383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2D6"/>
    <dbReference type="STRING" id="1450535.A0A317W2D6"/>
    <dbReference type="GeneID" id="37110526"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000013">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY79348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="302" mass="33777" checksum="C5B0C9D4C62AEB13" modified="2018-10-10" version="1">MTARQSSPTSDHSHSDGNVRKRVCKACDRCRLKKSKCDGSNPCGRCRTDNAICVFGERKKAHDKVYPKGYVEMLEQQQTWLVNGLQELYRRAMEGECWPGEPLKCEANGHPLTHDLLTRLGALDQTKGERFEENTESMQQELWKHNARHMQRQESSDGSSESAQSPIMPSRFSDPFGRQLSSTSSFSTPSQAQGPTIKSEPQMAPSNPAFVAPMTMQGVVNPLALQTPQQWPGNNFGTFEDMDLIGASEYSNLSFDDQVPSPMFNRQLPMSCMLSSSYMDTKSDYEDINQFLNANAPEIAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W305</accession>
    <name>A0A317W305_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative short-chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_537037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465485.1">
        <property type="nucleotide sequence ID" value="XM_025612180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W305"/>
    <dbReference type="STRING" id="1450535.A0A317W305"/>
    <dbReference type="GeneID" id="37114323"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY80883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="278" mass="29560" checksum="9C07F8AE3AD78D48" modified="2018-10-10" version="1">MAARGRLQGKNAIITGAAGGIGLETSILFAREGANVLMADISAPALEKAIAKVKEVVPTASRVETVKCDVSKESEVQAMIESQDSWGGTDVIFNNAGIMHADDADAVDTPEKIWDLTQNINVKGVWFGCKHAVLSLRRHKKTKGSIINTASVVALVGSATPQLAYTASKGAVLALTRELAIVHAREGFRFNALCPAPLNTPLLQDWLGDDKPKRFRREVHFPTGRFGEAIEQAHAVVFLASDESSFVNGSDFVVDGGMSKAYVTPEGPATAAPQNLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W497</accession>
    <name>A0A317W497_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_470732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465401.1">
        <property type="nucleotide sequence ID" value="XM_025608350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W497"/>
    <dbReference type="GeneID" id="37110493"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="134" mass="15187" checksum="408377ABB5DAB379" modified="2018-10-10" version="1">MSPTSKLYVAIYNAEGIYKHWNIFIDGPTAKEKIILQAMGSSTRYRFDESNYNARESPDLLLLVYLCHVQNSSFGAIRDAAREVVIHNEFPGYNCQDYVLELLDLLEKKGLVDGADEGYKCSKQMVVDEQEGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5G9</accession>
    <name>A0A317W5G9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_167738</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464962.1">
        <property type="nucleotide sequence ID" value="XM_025605909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5G9"/>
    <dbReference type="STRING" id="1450535.A0A317W5G9"/>
    <dbReference type="GeneID" id="37108052"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="333"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="741"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="741"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY79390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="870" mass="97403" checksum="F5FE38E598021FDA" modified="2018-10-10" version="1">MPSFSNDVAYQSSTATATHPRPFDPPPGKPTEKNSVGNTFLWTNWPNGDSNHLDAPPNDRQLTNGSAYSLNGPRSSASSYTKELPHSKDGSMHSLGNGSARDFREGGRPSTTLDRDLSRKSVETGARAGSPTASIASQQVNGTLNPRSLNGKPTMNGDYPRPSADELIAPDSVANVSGTRLSTSQPDDAGRLSPDLDRLSPSQKSPHRYSSPPVPSNLDGSAQEPANTGLRHRHTLQVPRTTSGRRSSRDNAEDAAYSSGRLSPTAGIRRTSFSLARRATRTNQSDILSDDAPPDEEAARWAEAIKQRRASKRRRRDDDDDERVIVGTKVDQNHVNYVTAYNMLTGIRFTVSRINAKMDRELTPADFEAKHKFSFDITGNELTPSARYDFKFKDYAPWVFRHLRAKFRLDPADYLMSLTSKYILSELGSPGKSGSFFYFSRDYKYIIKTIHHSEHKLLRKILPEYYRHVEQNPNTLISQFYGLHRVKMAYGRKIHFVVMNNLFPPHRDIHQTFDLKGSMIGRDLREEDLEKNPRATLKDLNWVRRNREIQCGPSKREFFLAQLKRDVELLKKLKIMDYSLLVGIHDGARGNEEKLRDKTLQVFQPGGDREEDASPNMLMRTPSKLENERKARELRMLIKRERPVPLDKAAAKMPEEILDERKFHVFYADDGGFRATHENGQPGEEIYYLGIIDCLTHYGMVKKIEHFFKGLSHDRTQISPIPPEGYGDRFINFIKGITMSKEEAERHREARAQGRPSEDRSESVERTMQAAEKEASKEVSLAQPRTLSTVRDPADPSGVVAPSFLPIVDEAGEASSVGGHSQHSRHGPSSAQEKELPPVPQANGTPFAGKGKGIVRDGQPDGGVSVSGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5Q1</accession>
    <name>A0A317W5Q1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_536916</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465741.1">
        <property type="nucleotide sequence ID" value="XM_025612146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5Q1"/>
    <dbReference type="STRING" id="1450535.A0A317W5Q1"/>
    <dbReference type="GeneID" id="37114289"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF291">
        <property type="entry name" value="IP11374P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="100"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="234"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY81673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="500" mass="56430" checksum="FD24300531DE811C" modified="2018-10-10" version="1">MKLKWSAVRGFTLAACLWASSAAILFSLVGVIAQHPPPTTPPQTWHYTQNYYYGIFAASLYIFIACLLLNYAASICTVHLTLQDRASVEDTSIVLRALTLATFLLGGAAIYVSIEGWSLPDALYWAVYTILTVGIGNIVPKTHLGRSLLFPYATAGITSLGLFVSSIASFSTRMGEFHLRFELQQAGINLHTAPHPHTKYEPPPKINISKARAIKSNYHRRRRWLVFIFSATAWLLLWLVSARIFKSSERSQGWTYFDALYFTFVSLTTIGYGDLYPTSIFGKSFFVFWALLAVPVMTALVGVMGQVGFRAVVYFVQRVWKMWPWGRYKSQIWSFLSKRRVDVPVGVSLLGLDANIEDEKKHPDVYDGSQHDDDLHNPSNSQHGQIKSTRHNLRLGEEIMALVGMLQGDVGNVDLYHEWVRIAPLLDKEYEQGFILSARGHYRPRVSEAICPDRVATDRNKEILLMMRLLIETLCSRMREEVQGGVNMEGEMATVCGWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6L4</accession>
    <name>A0A317W6L4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_152158</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465499.1">
        <property type="nucleotide sequence ID" value="XM_025605807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6L4"/>
    <dbReference type="GeneID" id="37107950"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF64">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="36"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="282"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="362"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY80897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="492" mass="52905" checksum="C02583CF93A8B348" modified="2018-10-10" version="1">MGWVHNLTVPDPHSHVPRVIAICLTFSIAACLAVALRLYIRIHTKRSAWVDDFAALWSAVLAMAYGAVAVAQTRWGLGLDAAYFPDENVVMFSKIQYAGGPIYTLALLGFKVSLLSSYLRIGGFVSAYRATIIVAIVAVVCNQLIFTFLLCFACDPVSRQWDMTLPGTCINTVASYYALAGTSLGFDIIIIALPLPVLCTLQLRLRQKIVLIGVFALGFFITIIQIIRIFTIKNLKTYTDSQPIVIWSDVEISLGVIITCIPTYGPFFHAFASTLTSSYNQHRNNNSPDSSTSPHSFQLRKTKTGSGSGEKGMDRERKRKQSRDLADASLDEVARGMGVAVGLESGLLFGSGIVSREVSVSRSRRSSCSRTGNRSRSRSRSPGEVVVGAGAGIWDGSVWDGGSAQTTVISSLPRVRTTESRTGSEVGLFAAGGAGGEERDPGMLEAGFPFSGMGMGMGSIMSSRGIVRSISGSGSGRGLQIQKVTEVRVERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8M7</accession>
    <name>A0A317W8M7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pantothenate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_469926</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465725.1">
        <property type="nucleotide sequence ID" value="XM_025608308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8M7"/>
    <dbReference type="STRING" id="1450535.A0A317W8M7"/>
    <dbReference type="GeneID" id="37110451"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="608"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="631"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="843"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="867"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="901"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="934"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="542"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY81657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="963" mass="108402" checksum="36095F4732DE8B93" modified="2018-10-10" version="1">MTRRIQRVAVIGAGISGVVSAAHLMAHGIDVTVFERNHAAGGVWLHDERKPLEPNYPSINPSVSEKHREDAQQEDSLLLEHAPPGPCYDGLKNNVATSLMRVKLNAWPEGTPEFVSHTVMKEYIQDTSKKAGADSVTLYGARVNRLRKDEQKWHVTWSTLTENDQPGRLEGREESAIFDAVIVASGHYHAPRVPDVPGLSKAKTQWPSRIIHSKGYRKPDTYAGKNVLLIGGGVSSTDLAREIGPLAKNVYQSTRNGEFDISSSILPDNGVRVSEIERFEIESPTVADNEPLPMVIHLRSGQKLCGIDAVIICTGYHITLPFLSEYHDDTTPAEKANETILVTDGTQVHNLHKDIFYIPDPTLAFVGVPYYTATFTLFEFQAIVVANVFAEIAELPSKSDMRDEYNRKIKEKGSGKRFHSLKDVEEFYVLDLLEWINAFREKHGLPVIEGHSDHWHVVKAAQRERVQLLLGAGRRRDSGIGELPALETAVMAPSPATVDDRAVDSSSVVQKNPKRKWVSYLWDTFDKSPEERRLLFKLDTAILTFASLGYFIKYLDQVNINNAFVSGMKEDLGLYGNQLNYMQACWTVGYVIGEIPSNMLLTRIRPRYWIPAMELLWTVLTFILSRSTNATHFYVLRFFIGLAESSFYPGMQYIIGSWYRKDELAKRSCIFHTSSGIASMFSGYLMAGVYNLGGRGGLKGWQWLFMIDGIISIPVAISGFFILPDVPEISNPFYLSEEEVKLAQKRMQFEGRKNREPYTKAKLKKIFSSWRIYLLTIVYIAFNNGAAGSQPVFQQYLKDSTNPKYTVDQINAYPTTTNAVQVVTTLVYAWTSDTILKGRRWPCIIIGACINIICYVSLAIWDIPTGWKWTCYILSGAGFGLSGLCMAWAHEICTEDNEERALVVGSMNEMAYVFQAWLPLVVWQQVDGPQYRKGFITVTIMSVILIISTMATRSMQHRDDGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8X6</accession>
    <name>A0A317W8X6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_469928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465760.1">
        <property type="nucleotide sequence ID" value="XM_025608309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8X6"/>
    <dbReference type="STRING" id="1450535.A0A317W8X6"/>
    <dbReference type="GeneID" id="37110452"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016312253" evidence="3">
        <location>
            <begin position="20"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY81692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="588" mass="64299" checksum="D879BD40FC24CB43" modified="2018-10-10" version="1">MALRVPFLPLIFFTVICIALVPDKLPLSAQSLSCRCYPGDQCWPTPEEWEALNATLFGNLIPIIPIGSVCHTDNPFTKYNPEACSDLIAHWPIPVTHYNTPSSPMAAWFTNFSCSPFTAPSAPCTPDPFVRYAANITSATDVQNVIYFAHTHNIRLVIRNTGHDYLGKSTGPGAIALWTHHLKSIAYEARYESSWYTGPALRLGAGVQGFEGQNAAHALGYVIVTGQCPDIGLAGGYSQGGGHGELASRFGLAADQVLEWEVVTAAGKHLTVSPEQNADLYWALSGGGGGTFAVVLGMTVRLYPEERTASGVVEFTSPTGLSDFWAVIRTFLVDTLPLLDASGTAIWLIFPDPTISGGLRFIAGPITLPGGEREDLQSYLSSTLESLQNLNMTYYYTIREFPSYHSQTASSPGVNITEYTIGGRLILRSTVESNTDALISALQSIAQHNTSISGLSLNVSRPNNKHPSNSVNPIWREAAMNIVIGIPFNYTDRQTDLNSQRLMTNVLVPQLEAPTPPGEDGGAYLNEGDFNQPDWQSVFYGVNYDRLLEIKDTYDPDQVFYGRTAVGSERWIEYEDGRLCRRFDTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WA34</accession>
    <name>A0A317WA34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sas10/Utp3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_495142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465844.1">
        <property type="nucleotide sequence ID" value="XM_025609253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WA34"/>
    <dbReference type="STRING" id="1450535.A0A317WA34"/>
    <dbReference type="GeneID" id="37111396"/>
    <dbReference type="OrthoDB" id="1924577at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF8">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="6">
        <location>
            <begin position="574"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="515"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="648" mass="72097" checksum="EB7362DDABFA7D89" modified="2018-10-10" version="1">MGKKRKAGGRPAAPKSDNLGPSKFDIEERFDDSEDEFQAGRDHILLEEAPEAKRRRKLAEDEELLQASDEEIMGYDSADDDDDLDDEEEFDEDDDYDEDDMDHAMSKSKSKRGGSPASEASEDEEEGIAAWGSSKKDLYNADQIETEADALEEEEEAKRLQQKHLQAMNEEDFGFDETEWVESGKGQEDADGGVVTEVLPQMEVTEDMSAEEKLKILKSRYPEFEPLAKDFADLQSTHEALAKAAQPFKVDDDSEDAPEFAPLSVVKFRALSAYLGAIGIYFMLLTSSNDASGNPAPLPPAQLRAHPVMGSLVKFRKLWETVKDLSEPEPATFEDPSDSEEIDDILSDAPAPKQKGKGKETQASKKKKDKVSKAQRAAEAAQAEAEARRAERLRQTEANLADLSKLVSGSSKKRVSQKTKSSKEDDSDFGDEDALTAKEAEEKAKQKRSLRFYTSQLAQKANKRNAAGRVAGGDADLPYRERLRDRQARLNAEAEKRGKQRLKDSEQLGGDSDEEDHRVANQLRGDKSDDDDYYDMVAARGKQRKDDKKARSDAYAAAAREGGHVEIQEEVGPDGKRAITYQIEKNKGLAPKRSKDSRNPRVKKRKKFEEKKKKLGSIRQVYKGGEGRGGYGGELTGIKKNLVKSVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCY3</accession>
    <name>A0A317WCY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_536538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465847.1">
        <property type="nucleotide sequence ID" value="XM_025612038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WCY3"/>
    <dbReference type="STRING" id="1450535.A0A317WCY3"/>
    <dbReference type="GeneID" id="37114181"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="202" mass="22618" checksum="2CDCE9BC0AEE7F66" modified="2018-10-10" version="1">MSDSTVGQTKQFGKGQRTVPHPAQKAQKWYPVDDESQPKKVRKTLRPAKLRESLQPGTVLILLAGRFRGKRVVLLKHLEQGVLLVTGPFKINGVPLRRVNARYVIATSTRVDITGVDAQTLEKVSAADYFTKEKKAEKKTEEAFFKQGEKPQKKVVASARASDQKAIDQTILASVKKENFLGSYLATTFSLRNGDKPHEMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDS8</accession>
    <name>A0A317WDS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_121694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466003.1">
        <property type="nucleotide sequence ID" value="XM_025605579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDS8"/>
    <dbReference type="GeneID" id="37107722"/>
    <dbReference type="OrthoDB" id="4510447at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="354" mass="36299" checksum="21F17D54E2513C71" modified="2018-10-10" version="1">MLRALKTRLVCKQWTARFCHLHIGNVGVAHQRRHVRHTTAAAKVLGHLSQLGVAHEVAEHVGVAHQVLSHAREHGVAHDGSEIGHTTAATATTTAQHASKGRQIGHAASTTGCSSGIIDLIGRRLGATLGLLDLLLGGLKTPLHSVTTTVALGLDTLLVRLLGTVVIGQVETSQSQTAPGLGVLGVHGGGKLGILRRLLVLSGCGIGSSPVGEVDRVGGSNGQGLGVQIDGSGIVLASHGTVALRLQLIRLGRRGTRLGLLFTGLGRVARGLVPQLLVDTVDAGQRLSTQSILHSSLVRRVDLEGIGNAGLGDLDGFGVIGGQGAILQAGTEEVDDGERQALLGLCGGLESGMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE07</accession>
    <name>A0A317WE07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial F1F0 ATP synthase subunit Atp14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_625140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466538.1">
        <property type="nucleotide sequence ID" value="XM_025617258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE07"/>
    <dbReference type="STRING" id="1450535.A0A317WE07"/>
    <dbReference type="GeneID" id="37119401"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13669" checksum="78CD0337286BA1A5" modified="2018-10-10" version="1">MMSQSLRASRSLFSRVSRQQVSSVSRRTFLTSAVRQADPVQELYLRELRAYKPTPVKPGDADAHVQKFAPPAAPLSPEEANLANDLKSYESQEVEVEGQAVAGEAAPVEESWFVEEEEEAPAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WG14</accession>
    <name>A0A317WG14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannitol-1-phosphate 5-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_566740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19661"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:61381"/>
            <dbReference type="EC" id="1.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466566.1">
        <property type="nucleotide sequence ID" value="XM_025614581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WG14"/>
    <dbReference type="STRING" id="1450535.A0A317WG14"/>
    <dbReference type="GeneID" id="37116724"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008926">
        <property type="term" value="F:mannitol-1-phosphate 5-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019592">
        <property type="term" value="P:mannitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000009">
        <property type="entry name" value="Mannitol-1-phosphate 5-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000316">
        <property type="entry name" value="Mannitol-1-phosphate 5-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00196">
        <property type="entry name" value="Mannitol_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023028">
        <property type="entry name" value="Mannitol_1_phos_5_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002652">
        <property type="entry name" value="PRK02318.2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524:SF0">
        <property type="entry name" value="ALTRONATE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30524">
        <property type="entry name" value="MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="198"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY84641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="381" mass="42094" checksum="8B8D1284D5122013" modified="2018-10-10" version="1">MGKKAIQFGGGNIGRGFVAEFLHEAGYEVVFVDVVDSVVESLQNTKSYDVTEVSEEGESTKTITNYRAINSKHNESDAIQEIATADIVTCAVGPNILKFIAPVIAKGIDARTESKPVAVIACENAIGATDTLHGFIKQHTSSGRVESLYDRAQFANSAIDRIVPSSLPTMKFYEWAVEKTPFGSVGHPDIPAIHWVDNLEPYIERKLFTVNTGHATTAYFGHIRGKKMIADALEDQEIRGLVHKVLDETASLIVSKHGISEQEQKEYVDKIISRISNPYLEDNVDRVGRAPLRKLSRKERFIGPASQLAERGQKYDALMDAVEMALRFQNVPGDNESADLANILKEKSAEDATSHLTGLEKDHSLYPAVLERVRKVQEETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WG83</accession>
    <name>A0A317WG83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_625562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465975.1">
        <property type="nucleotide sequence ID" value="XM_025617295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WG83"/>
    <dbReference type="STRING" id="1450535.A0A317WG83"/>
    <dbReference type="GeneID" id="37119438"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY83190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="615" mass="69354" checksum="D1E09A95D3BA282C" modified="2018-10-10" version="1">MDDADALAPRGGRARSACDLCRHKKIRCDGEKPACENCHFAGVVCTFTFTGQPRKTIREQLSEAKARVRELEEFIAARDLSLSSSPLRDELQSHVSSSPCPPLSLSSAPSHPQDSSVFDTALEIFQQHLEWSWPGVAHSPQRSSFYATIYRQTGTILDMSGFWARVSDSYKSQYPATQPKTTSPKWPSYQLVQQCLNYYSANGLYAVFPIIDVAAAQAIITDHVSGRADARPLAEKACLFALTAFVTKLHHHQPMFADTDSDGYVQAVLTLVPKLMLEPNDVRKLEAFLIIALHIAPAGKPEQSQLFLSMAIRILYHLGAHRKSPLIPNDESHTHLRAMFWLCYTMDKEMSIRSCLPPLLQDVDCDLNFPPTYVESFDLQFLPTTPSTPHLLLPTDIRVAMLKSKVYHGLYSCQAQKFPEARRLEHIRQLDQELSDLKASFPVGFRPDSYSPGGTERSHSPVNVHNLGLRGINIHLEYYYCLRKLHEASFTGSLSMPLPSSLELYYQASRSTLLYYLRASGLVDRFSFWIHAQFILSSILSLFWCLIDVPTASTFSRDLRILQDTKDLFASFQGNMNGHTHTSDEQFFPPAYIMHEFLELLISLARQVLARTKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH11</accession>
    <name>A0A317WH11_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_566495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466771.1">
        <property type="nucleotide sequence ID" value="XM_025614557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH11"/>
    <dbReference type="STRING" id="1450535.A0A317WH11"/>
    <dbReference type="GeneID" id="37116700"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001151">
        <property type="entry name" value="Large subunit GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="177"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="267"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="642"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY85754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="671" mass="75139" checksum="D0E5534D579F7F53" modified="2018-10-10" version="1">MVLAKSKNSVGLGNSLMNDRFGKGKASALKKASHNAAIARKNEKGETYITNAPTEAAWVKMRSITEQAALDEFLSTAELAGTDFTAEKMNNVKIIHTDQKNPYLLSASEEKSAVKKHQKNKNRLTVPRRPKWDQSTTRQQLELMERESFLNWRRGLAELQENHDLLMTPFERNLEVWRQLWRVIERSDLVVQIVDARNPLLFRSEDLEAYVKEIHPQKRNLLLVNKADMLTEKQRAAWADYFERHNISFRFFSAHMAKERNELLQQDLGSDDESDVEEEVPAEEQLAEDAKALDIQDAPEPQEEHDGGLELNPGASSSASQRTEILNVEELEELFLSNTPDTLPDNNTTDSPNKAKTVIGLVGYPNVGKSSTINALLGAKKVSVSATPGKTKHFQTLYLSPEIMLCDCPGLVFPNFATTKAELVVNGVLPIDQQREFTGPGALIAQRIPKHFVENVYGIKINTRPLEEGGTGIPTASELLRAYARARGFATQGLGQPDESRAARYVLKDYVNGKLLFCHPPPPAQEGADPIDPLEFNQDLYDMAHLPPRRQAQLAKLLQNDESVDPDTLALLLTSQKPIPGLRSRKLDTGFFGPGAKTTTGRITLPFNAQYTEQGQEIRKQLTGRKERMMVALERGVDVSEVRGGSSKKHFKANKRRAKKVRKNTANDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHA5</accession>
    <name>A0A317WHA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_536192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466542.1">
        <property type="nucleotide sequence ID" value="XM_025611958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHA5"/>
    <dbReference type="STRING" id="1450535.A0A317WHA5"/>
    <dbReference type="GeneID" id="37114101"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053187">
        <property type="entry name" value="Notoamide_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47256">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY84617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="614" mass="69746" checksum="1A43B3514909E484" modified="2018-10-10" version="1">MNTENQGKHLPSLAPGPRGPVAAGATTLAKSRKNSTACLPCKQAKRKCSGRPPPCKACQNTGLCIFDETLDLRRKVAARRTQGELEYYRGLLYSLLETLRSSDEEKARQMLEKIRGNTHLSDLVTVIDAPVNDLSDASSEHSKSVGVAEDAIAQHERPGIDAHLRITVERLCDSPLFQVPSRPWTAVTNDDHIVSHLVSLYFTWDHPLLQVVDQEMFLRQMATKATNSECCTSLLVNSILAVASIYSDFPEVFALSDDETSRGQHFYMEAERLWNAEEGCVSLANIQAVALMSRFLKFQGKDDLSWLMLRQAVQLAQDFGMFTSPRTRHRQWEGASARLQHVGAITAWGLFILNSQTSLQSRKVAELKPPKYKPYTENALDDDIMWTPYPRFNQFDRVSKPAHLRFVMTKMIDLTEIIADIPDLLFDKGPDMAVGELWITAYKKWGRLQRWLESLPTILENDDEKPPQILYLHIRCHHTIMALFQFFLEHQHFGPASHPAEFEQARLNQLRSAKQVVQYLRSYHEAYGLRHIPRQILEPTNSSLLVFLGALNEEDSKDAFVELCRFLVAFSKRLALAKEMLRNLENIVQSSKLTLPPEAVAVLDHRGQETSQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WI01</accession>
    <name>A0A317WI01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_566951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466298.1">
        <property type="nucleotide sequence ID" value="XM_025614592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WI01"/>
    <dbReference type="STRING" id="1450535.A0A317WI01"/>
    <dbReference type="GeneID" id="37116735"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="216"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="305" mass="34868" checksum="4A4A3A1C4D1A2320" modified="2018-10-10" version="1">MDDKRSRVSDYTVSEKTPATPRIPGKTVRRAWGFLHRALFYLSQHYCSWFNIPFNAQIVQLPFGLVMKWTDRTSIEEAAAAMQMAAAAGIPVPKFLSCGEHPADPFNRRISILMTRIPGVPLENSFDPLQVETEEPWLNELRTCVHSMRRWCLPNPTAICSPLGTCLRSPRIPSHIMGPFANTDDFYEYLLTPASSHGFESIVEYNQVLSCARRIQDRPHRIMFTHGDFKAHNIVVDDDGHLSGFSDWESAGWYPEYWEFTTAMRFGRGSWWFQVAEWMGGDQYADELASDIALNELTVDSYIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ89</accession>
    <name>A0A317WJ89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_85392</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467107.1">
        <property type="nucleotide sequence ID" value="XM_025617710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ89"/>
    <dbReference type="STRING" id="1450535.A0A317WJ89"/>
    <dbReference type="GeneID" id="37119853"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016433945" description="Palmitoyl-protein thioesterase 1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY86516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="344" mass="37878" checksum="E68509537751D855" modified="2018-10-10" version="1">MRPLPPLLTLLALPLTATTHPTSQTPFQTTPSPPPTTNTTSELRPLPLVIWHGLGDNYLNPSLQSLITLAEKTNPGTYTHLIHLSPSSSADRQATFLGNLTTQITQVCAQLASDPILSTAPAINALGFSQGGQFLRGYIERCNNPPVHNLITLGSQHNGISQFQACEWTDLICRGSEALLRSGRWSPFVQGRLIPAQYFRDPSSEAEMEEYLANSNFLADINNERAVKNATYKENLGKLNKFVMYMFGADKMVHPKESSWFAEVDGQGGVVGLRDREVYKQDWLGLRGLDERGGLVFRTLEGGHMDVGEGELEGIFEEWFGDVEVEFDEGGVGRRVLGVQGGNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKJ1</accession>
    <name>A0A317WKJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_97643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466819.1">
        <property type="nucleotide sequence ID" value="XM_025617771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKJ1"/>
    <dbReference type="GeneID" id="37119914"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY85802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="71" mass="8530" checksum="5386F465AEC8029B" modified="2018-10-10" version="1">MTWVKRWLSGKMNDKWLLIYDNYDPESFSSSFAFDLERYLPEIRQGVTIITSTFRSLTYGIDPRGRISRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN67</accession>
    <name>A0A317WN67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_517539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467029.1">
        <property type="nucleotide sequence ID" value="XM_025610000.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WN67"/>
    <dbReference type="GeneID" id="37112143"/>
    <dbReference type="OrthoDB" id="5363079at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04497">
        <property type="entry name" value="hPOT1_OB1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00976">
        <property type="entry name" value="Telo_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="2">
        <location>
            <begin position="1201"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1354"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1384"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY86438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1429" mass="155886" checksum="ADED4971BED21FEF" modified="2018-10-10" version="1">MSHVYQAAAMMDAPEQQPPVSEPLRSTPVPIAQLSPTLENLSNSSVHAVVTLLWPYSSSTRSLGLLLAEPDFRLRRTNGQVKVVFHGSVAEEVAKSQVGIGDSVYIGLAGSRFVENDTTKQTPGRFVAWDVHFDSGVFIEIWRSSQHLSTVKVDRPLSPLPAADDATAPPATPTVNSHAALDSRNPNGGLQSWQSPAFIERSRPSLGHLSSSLFDPFAEEDGFVLGKGRKRPRFSMRGSDWRLVDEPASPGDTDIPGDWTAMFDDEAWLRSESGGDDMADEARQSPEPSETRDAVSIPGGSPDGAQAADVTTEQVTVTLEPSAGKQLDEVKSDARFLLPQSISRTESPGQKRNNVPHFAGHLPIDTPRLHPIPSPGLPVPSPLVSTSNSPLGYFGSVSATPPPQSTPPTTANQEVTGLASEDVSDKQPDLAVGQTDEGVATTVNSEPIALSQPGPQEHGIDSQPEIAHPVSVHETVAAEKQGPEDVEVRAEQVEETVTERAASDVAEPVRDENKVGEGAKPGEIEIADIEEDEEMLEAEESPRQRGGIHISQEKGIHHRVNGTRDENYESESASHSSVIESSRPGDMSEDEDATEEDVEPRSKSRYDIELVSDSEAESPAKPHDTVRRAHEYHIEGEDEDEDEDEEMEDEEDISDEDGSDSEESEGAYDEDGYDDRVDSESEFESESDEMESRAQQPIRTVEPEVIVLDSDSDDEPPPSIQRRPFAAQEPVRSRSDLSPSADEASSYGTSESGDDDEVEMEGEEDDDDAEGYSSGAEGEEWSVEDDQEADEREVETVDVESIYQIESERDEEWHSDRVQAHERIADAQSDGAVSEKHLEPEQTSARDLDDEQPDDEDADADEMEVGSARDEHMHDEQKDQEQVEEKVDNTQIEVEHIEGEAAADHGLEDAEAQSLVETDRDVAPGTSPGGERPSIAIDEQPGFHVGDEESRTAEVVTQELIHEEIRYISDDAHIVQQADASTEPILRFSEPPIDPELLNAGTFSSEDQTSMSRQHSADTSQAQTQETEISGVPEQAQHIDPSLSLGGTSQSLSLPISAAVTSDMPILPLDQLVTPEPSQIIGVDKDVPSVLPVDEAPPTPEPTQEILAVQQETETPPTIEPVVNTTATAEVDNLPQDEDSDSESGSVSTALEEQEYVSEEDDKGVQTTHSEDEVLLVGDDRARLVNLNRNFPGLRSKHSYFSPLATLIDHFNALTDTISVVSEVRPAIRATSGKKDYILTFGLTDPSLAGTILYAQIFRPYKTALPSLEEGDAILLRNFTVKSFKHSMTLASVNTSAWAVFTASQPDAHIDGPPVEYGPEEQSYATDLRQWYQEDGMAMVADYQLQASIEQESREATPAAFSDSGSVNSIGVDSRADSSFSSRGSRRRKSHRRITIHELRDGRRYAEVGSPTSKESIHELRDGTVYANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNH8</accession>
    <name>A0A317WNH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MGS207 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467807.1">
        <property type="nucleotide sequence ID" value="XM_025611682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNH8"/>
    <dbReference type="STRING" id="1450535.A0A317WNH8"/>
    <dbReference type="GeneID" id="37113825"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="47333" checksum="90437F54E5AA242F" modified="2018-10-10" version="1">MLSFRLPSINKLLPWGDRVVLALPSVKIHEIDTALEKPARALKHLLKLNHANHAILYNERRFHNHAPHILCSSFLQGADADDLNRVYEAESELLEPWTDAPAEISIHDWRDFLGYREYQRAFVDFFEDELVRQGYDWKSVVSDYLFSGNEPLFNSLAADLGHPLIHLAYAFELSSREVAMEALAMTSTCYGGIHKYLDDPSYTQTEPSYQSTSVFEIIDKVRTDKQFNGLFGTPGDHNMEILFREREAALLDHWNAWKIQDPVKQFRESQELAVAILMGTHSDRTSEQYDFFFVHILTTSHAVRILLPLIPSQFQVSLVRQWWLLTLSIYIAQLRPELDLDRIRKYELSGRDWTCTAKQAVKGEYSTDAHYVKALRACRECADTWGDEDSFYLKAAVKFGEEFNGWGGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNK9</accession>
    <name>A0A317WNK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_98602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466857.1">
        <property type="nucleotide sequence ID" value="XM_025617778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNK9"/>
    <dbReference type="GeneID" id="37119921"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY85840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="138" mass="15029" checksum="AAA987FC832FDC0B" modified="2018-10-10" version="1">MNSRPFSGSPILACPYEACRPMIPRLHIDSLQPLWLLFRAKSHTMLRLILVLPSPDLSRLARATGRIQATFKPGLVGTATSSLAPVLSASPSSSSPRPKPPSPTLLFIRARQNDRISLAVDGHPYYRLCGPAGVSCLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQC1</accession>
    <name>A0A317WQC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_546357</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467326.1">
        <property type="nucleotide sequence ID" value="XM_025613290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQC1"/>
    <dbReference type="STRING" id="1450535.A0A317WQC1"/>
    <dbReference type="GeneID" id="37115433"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="118"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY87118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="551" mass="61144" checksum="424C08C5AABB1F03" modified="2018-10-10" version="1">MSIPHSEQRPGLPRTETRESLENQGISEKAPPMDYNYPDVGREEDPVFPEEYTVETSTGLVPERTLEHMRSRTPSRRSSSPDSSEDVEKATEPAEFVTFTINDPENPFNWSRTYRWYVTLVAALLVVNIAYGSSIVTGGLGLIEEKYHVSLEVATLTCSIMVCGFAVGPLLWSPLSEIIGRRPVYIISLALYTIFNIPCALSPNIGGLLVCRFLCGVFSSSGLSLAGGTIADIWNLEDRGMAIAFFAAAPYCGPVIGPIVCGWINVGSHRLDLFFWTNMAFAGVVMIIVGLIPETYAPVILKRRASKLRKETGNPNIITEQEKHKLTLRDIIRTSLIRPITMIATEPVLDLMCMYIVLIYAMLYAFFFAYPVIFGKLYNYNDGQIGLMFIPILIGAGFSLLCTPAIEKHFHRICLSRPPTPEDRLIGALIGAPFIPISLFILGATSFKHIIWVGPASSGIAFGFGMVLCYYAVNNYIIDSYQKYAASALAAKVFLRSGGGAAFPLFITQMYDRLGLQWASWLLAFLGVGMVLIPYTFYWFGGRMRARLNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQG6</accession>
    <name>A0A317WQG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_515526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468035.1">
        <property type="nucleotide sequence ID" value="XM_025609925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQG6"/>
    <dbReference type="STRING" id="1450535.A0A317WQG6"/>
    <dbReference type="GeneID" id="37112068"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="254" mass="27405" checksum="F27AA3B53313BFA4" modified="2018-10-10" version="1">MATEKPSIVIVQGSFQTPLVYAKLATGLRNLGYSVIHPSLPSCTDVEADDFSSRTMEDDARTITEILEQLIEKEEKSVVVVMHSYGGIVGSTAIPQSLAYTSRHAEGKKGGVLCLFYYAAFLLSEGASVIGTFGESPNNYVTSDGCFRIKDGAKTLYSDLPDAEAALWESRLIPQSYLVQTTPTTRAAYEYIPSTYLICVGDQAAPAAFQERFAQLARAEIDRCTAGHSPMLSQPDMLVEKIAAVVDKAAVASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQU8</accession>
    <name>A0A317WQU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_556214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468181.1">
        <property type="nucleotide sequence ID" value="XM_025613846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQU8"/>
    <dbReference type="STRING" id="1450535.A0A317WQU8"/>
    <dbReference type="GeneID" id="37115989"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="601" mass="66638" checksum="D8293740A77807A0" modified="2018-10-10" version="1">MDSTIAPALDNSRNSRSTLACLPCRSRHVKCDGKQPSCSRCDAGAKQCLYARSRRGGLDRATLAERRKQRAAASQAGSQQPEKSRSQLVEIDSHSSWSPRDAGTASDGSSMASPAAIQIHADNIANDPLIDSYYRNFHNFHPFLLPQSHLMKIYQDPSRQSSLRPLIATVRLVGYIVKARGWSLPLKEYAEAWFLQAPPTDPVLVQCRLLYSIVLFWYDYKADAKSQIDAAIHLAIELQMFRQEFAAEHGASDPVVKECWRRTWWMLYTVDAYFAGTLGTMTSELLDIDATVELPCEESEYESGDIPKSKTLQEFDCREFASDETAFSSFAYLIGAVRCAVLALSTSPKMAVKEDSMQVIQAADSILDGWLLLLPKDRKQVMAKTGEVDELMFQAHLLIHVATVGLHRPFSDLKFNPIEDISSCARDPAPDIPTPELVNVHTVRVLRSVEAQIRLLALPVSEFHHTPFTTCMISEGTLALLSSCCFLLKGVELTVARAQIRMTIGCLRALGELWPRTARNVREIQTIAHHVLGLESARNHSTPPSSQVGSGGGQGTSGLDAGAWGDSIDIVPSLNSLEDLCGWYNLDNFDTDYHWEMNNMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT20</accession>
    <name>A0A317WT20_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative meiosis induction protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_40397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468464.1">
        <property type="nucleotide sequence ID" value="XM_025607383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT20"/>
    <dbReference type="STRING" id="1450535.A0A317WT20"/>
    <dbReference type="GeneID" id="37109526"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="25"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="683"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY89553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="782" mass="85657" checksum="486510D54427F717" modified="2018-10-10" version="1">MTVCYDHSSLRSAAPTSVASLEDRFEVLKEVGDGSFGSVAVARVRTAGSNVARRGTMVAIKTMKKTFDSLAPCLELREVIFLRTLPPHPHLVPALDIFLDPLSRKLHICMEYMDGNLYQLMKARDHKPLDGKHVKSILYQILSGLDHIHAHHFFHRDIKPENILVSTSAPNDSAFSRYSNLVTPPSTPPTYTVKIADFGLARETHSKLPYTTYVSTRWYRAPEVLLRAGEYSAPVDMWAVGAMAVEIATLKPLFPGGNEVDQVWRVCEIMGSPGNWYSKSGAKLGGGEWREGSRLAQKLGFTFPKMAPHSMDSILQAPQWSAALSQFVTWCLMWDPKNRPTSTQALNHEYFADAIDPLRPKSSTARLLGRKQSDKSFKSANRDTNDSPTLAYKSSWFRRSLIGRSDSPVPPVEKENSSKQSVSYNNSELQVAKSKPAPSKRATWANGAPMPILPSIRPVSPLSNAVTAQANSSLAHSGDSANSKASKKIGRQLSVNSHGNHYADIHRQEAERALNGGAMLSPAITPKESFFSHLRKRARRLSGRNQANTADDVEANAGCMPWSNRSSLALDSVNVSEPKPNSDLSELDKALQTVKCSLDSAALGNVPVQITSAVDGTKRQSMPQGSIRAMGESPVSTNGTGGPISSRNRRAMQMSNNPIHRYETPEEEDELLDEVLHSASKAARRLAQTEVPSDVTSNYNRQPLGNDSSRPLPSPYPTPSPSAKCDGVSFGHSETTPCRRLPLPEEQADANSSRQWPTPPYEDGEWAKPAPAKFLTGSATCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUX2</accession>
    <name>A0A317WUX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_465766</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467843.1">
        <property type="nucleotide sequence ID" value="XM_025608129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUX2"/>
    <dbReference type="STRING" id="1450535.A0A317WUX2"/>
    <dbReference type="GeneID" id="37110272"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF13">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="51"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="513" mass="57300" checksum="BEFF439802A12D2E" modified="2018-10-10" version="1">MPVTSNTGRRKDAPQPTCDQVETASCPRILTEADCYSELGFSFSTAKKWTIILVIFLVQTSMNFNTSLYSNAISGISEEFDVSKQAARCGAMIFLVLYAFGCELWAPWSEEFGRKPILQLSLFLVNIWQIPVGIAPNFATIIIGRALGGICTAGGSVTLGMIADLWEADDQQYAVACVVFSSVGGSVLGPVVGGFVEEYLPWRWNIWIQLIFGGFVQLAHLVLVPETRTSVMIDRIAKRRRTKGEDVYGPSELTPLLDRFSVEEILQTWLRPFRMLLTEPIVLCLSLLSGFTDALIFIFIQSFGLVYAQWNFSTVAIGLSFIPIMIGYVITWIMVIPVIKCNVHERRTKPDDERAQYESRLWWLLYTAPCLPIGMIGFAWTSLPQVHWIGSMFFSALVGIANFSIFMGTIDYMICAYGPYSASAAGGNGWARDFLAGILTVPATPFYENIGRKYHLEYASTILFCISTLLVATVYVIYFYGPVLRKRSPFAQQLSDARENIHSRMVGNIRGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVH0</accession>
    <name>A0A317WVH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Neutral protease 2</fullName>
            <ecNumber evidence="15">3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Deuterolysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_464767</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 15">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="15"/>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468210.1">
        <property type="nucleotide sequence ID" value="XM_025608084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVH0"/>
    <dbReference type="STRING" id="1450535.A0A317WVH0"/>
    <dbReference type="GeneID" id="37110227"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 15 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="8 13 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="active site" evidence="12">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="160"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY88848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="330" mass="36178" checksum="D4C59B035719DA10" modified="2018-10-10" version="1">MPGTSLDVILSQVSNTHIKAEVKNTGNEDLTIVHLNFFGDTAPIKKVSVFHNETELDFNGIRQRLVLENLTHDALTTIHAGESLIDEFDIASTLDITDSGPITIHTSGFVPITTDSEITSYLPYTSNTLTITIDAAKAATVPKALTIPPSLHRRTRLSDCDDNRAAIMRAALDNAMRMSVAAANEAWMGSAARLEEYFKSSSQETRSLVANRLAYIAAEASLNAERTTYYCTDKFRACGPRTLAYTFPQWNVVVNCPIYWSILQPVQKACHAQDQANTIIHEFSHAPGVYAPGTDDLGYGYQAAMRLTGNQALRNADTYTLFTNSVFAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVT2</accession>
    <name>A0A317WVT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_25276</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468837.1">
        <property type="nucleotide sequence ID" value="XM_025606444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVT2"/>
    <dbReference type="STRING" id="1450535.A0A317WVT2"/>
    <dbReference type="GeneID" id="37108587"/>
    <dbReference type="OrthoDB" id="18472at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="254"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="558"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY90459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="656" mass="75613" checksum="87C8F3B9D13096C9" modified="2018-10-10" version="1">MALNLDTSDRPAFRLPNPPPLLHTRTGNDSLDRPSTPAQTEFTSPVQTPQGSPSKNRMPPGAIDLPNVFEKALKLNPTSPTKGTYNHYNHPMFAPPRNSEDFTESVIRQPPGSPTRKSNKENTPPNSTRLTKDLGPNPAAAAISRHEPYQQRDLESIQRRQVPMRGLTPEELEKLQNPRVKRLVNVTQLYFLDHYFDLLSYVHNRQNRYSQFRTAYPEPPVTPMEDYEPALLKYLGRERAHLRKRRTRLRQHDFQILTQVGQGGYGQVYLAQKKDTREVCALKVMSKKLLFKLDEIRHILTERDILTAAKSDWLVKLLYAFQDEDQIYLAMEYVPGGDFRTLLNNTGVLHNRHARFYIAEMFSCIDALHALGYIHRDLKPENFLIDSTGHVKLTDFGLAAGMLNPGKIESMRVKLEEVGNTPVPFGRPMEQRTVAERRQGYRTLRERQVNYAKSIVGSPDYMAPEVLKGEQYDFTVDYWSLGCMLFEALAGYPPFAGSTVDETWQNLKCWQKVLRKPVYEDPNYFLSRRTWDLITKLVASKEKRFKNIQEIHAHDYFSEVDFNHLREQRAPFVPELDSETDAGYFDDFTNEADMAKYKEVHDKQRALEEMAERDDKMSKGLFVGFTFRHRKPAMDGLGRSSPRKPIATDGSFGTMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWS9</accession>
    <name>A0A317WWS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_594444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468558.1">
        <property type="nucleotide sequence ID" value="XM_025616198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWS9"/>
    <dbReference type="STRING" id="1450535.A0A317WWS9"/>
    <dbReference type="GeneID" id="37118341"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="46"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY89647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="480" mass="52736" checksum="3199CCF61CC638E0" modified="2018-10-10" version="1">MEEKGTSSHIDRATEEHGLGGLMTKEVVNLDPNDPQNWSTAAKLTTYLTICFYTFLANVNSSNFTVATKAIIAEFHVSQTQAGELVCFNVFLFGLGNIFWVPLMRVIGKRPVYLVSMLLLSTMNVWSSRATSYGELLAARILSGFAAAAADATVPAVVSDMVAPHERGHYLMIFHLALTSGLFLGPLINAYLVQDEDWRWMCYFLAVAVGSVLVVAIFTIRETTYLRHVVSRRNYRDWLSLTHGYNPDASFIRTTWDILRNAAYPQLLWCSLTIGISVGWNIVVQLTASRTFTAPPYNWPAGSIGLLSLSGFIGSLLAFYLGGRLIDIISTRYTRHHGGPRLPEYRLPVMIIPGTIGPAGILIFGLCVAHQTHWAGAAVGYAMQAFGVAAISNVAVTYALDCYKPITGEALVIIFVIRNTIGMLLSLYAADWINRQGAAKVFGEMTAIQGVSVVMAVPLFIWGEKLRGLTGRYGPMKRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0H2</accession>
    <name>A0A317X0H2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_488361</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469503.1">
        <property type="nucleotide sequence ID" value="XM_025609065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0H2"/>
    <dbReference type="STRING" id="1450535.A0A317X0H2"/>
    <dbReference type="GeneID" id="37111208"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016253046" description="Peptidase S53 domain-containing protein" evidence="10">
        <location>
            <begin position="16"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="11">
        <location>
            <begin position="222"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="554"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY91775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="637" mass="69853" checksum="E50835DCD1BE0FD1" modified="2018-10-10" version="1">MRASLLFLSVTAVLASPTPPNYVVHERRDVLPNDWIEERRLDEGTLLPMRIGLTQSNLDRGHDLLMEVSHPHSSRYGQHLSTEEVHDLFAPSRDTVETVRSWLESAGIPPSRISQSYNKQWLQFDANAVEVEQLLQTEYYIYEHTDTGRSHVTCHEYYVPESIQEHIDYITPGVKMLELRGTRSKKRSAKKRSFGGLPPILGALPIAISKLFENPLAYCDLAVTPECIRAMYNITKGTTATEGNELGIFEDLGDVYSQEDLDLFFSALASDIPQGTHPILEAIDGAVAPTDVNTAGAESDLDFEISYPIIWPQNSVLFQTDDPVYENDYSYLGFLNNFLYAIDGSYCNDTSSLDPPYPDPAPGGYKGQKQCGVYKPTNVISISYGASEADLPVAYQRRQCQEFLKLGLQGVSVIIASGDSGVSASDDTCLGNDGDVFVPEFPATCPYLTAVGGTYLPLGASASGDQEIAVTRFPSGGGFSNIYARPSYQNQSVETYFSRADLDYPYYESVNNNSFNANGGIYNRIGRGYPDISAIADNVVVYNKGESTLIGGTSAAAPAFGAMLTRINEERLAANKSTVGYVNPVLYEHPEAFHDITVGSNPGCGTDGFPVEKGWDPVTGLGTPRYWDLLQVFMALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3W4</accession>
    <name>A0A317X3W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_555458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469376.1">
        <property type="nucleotide sequence ID" value="XM_025613798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3W4"/>
    <dbReference type="STRING" id="1450535.A0A317X3W4"/>
    <dbReference type="GeneID" id="37115941"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF8">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="33320" checksum="C5F4C5A2A94C6601" modified="2018-10-10" version="1">MPSNLLATLYSYPRPPPRRRTKPLQILCVGLPRSGTESLSLALTHLGYTTYHGWDIVFDDPPYTEQWARLAERKYSNPHPHHNKPTQITTTEFDALLGHCDAVINTAAALFNPEIITAYPDAKIILNTRKDVDAWHRSALKTLAEEGADQWSLWFLRLWTADMYWLWRLYCTFGYPGLFRGRTTREGLERNGKRVYMEHGEMVRGMVKEEGRLLEWNVEDGWGGCFLGKEVPDVPFPKANDPAAFRQHMQDLVRPRVMRSLRNFALCVASVGAVGLRLFGGEWEEREWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4M1</accession>
    <name>A0A317X4M1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_622425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470046.1">
        <property type="nucleotide sequence ID" value="XM_025617081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4M1"/>
    <dbReference type="GeneID" id="37119224"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="282" mass="31560" checksum="7D817D392C7D8A93" modified="2018-10-10" version="1">MAPGTRPRNGEGARQENQPKIGRPRKYHTKEEADSARRRLARDLYHRRKSKADNPTARRIRFDTVLRPQDFEGAVPSSPPSTPMKRWNDKKPHDASRNGLDSSAHPSAQPGTNSRNVNPPPPSVRNCQCRVNMMLQVSRLECAIREMAILQLDKMVKATGDVIRSCQQSTRCGCYVGPVDLVCIMSVFEQTASCFDYIAKSGFDGNGKMLVLDLIRQSNTLMDSVDALAQKMMAPSRQKDPGIKAMDRSPVCLNQLNLTYVREAIATFKELFGFITKVHGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4Y3</accession>
    <name>A0A317X4Y3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_512317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470022.1">
        <property type="nucleotide sequence ID" value="XM_025609807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4Y3"/>
    <dbReference type="STRING" id="1450535.A0A317X4Y3"/>
    <dbReference type="GeneID" id="37111950"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="275" mass="30164" checksum="473730AB8C373599" modified="2018-10-10" version="1">MGSTTVGVLALQGAFYEHVQLLKKAAATLSADNVDSPSQWEFIEVRTPQELERCDALVLPGGESTTISLVAARSNLLEPLRDFVKVHRKPTWGTCAGLILLAESANRTKKGGQELIGGLDVRVNRNHFGRQTESFEAPLDLPLLGAEQPSFPAVFIRAPIVEKILPHQEGEQVDEAQRDETVIAPSRQAEDETARQAMADSVEVLATLPGRAAKLASQGTHIDADKETGDIIAVRQGNVFGTSFHPELTDDARIHSWWLRQVEESVRRRHAKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5M4</accession>
    <name>A0A317X5M4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_531868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470634.1">
        <property type="nucleotide sequence ID" value="XM_025610995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5M4"/>
    <dbReference type="GeneID" id="37113138"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="63" mass="7196" checksum="1F5F8603EABD7B34" modified="2018-10-10" version="1">MGLFAGHGALEQAELDNFGVDWVIHYSFEEVGKESPRSGPVDTVSHFRLSRQSFRRRSKNFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6C4</accession>
    <name>A0A317X6C4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative amino acid aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_532095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470894.1">
        <property type="nucleotide sequence ID" value="XM_025611051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6C4"/>
    <dbReference type="STRING" id="1450535.A0A317X6C4"/>
    <dbReference type="GeneID" id="37113194"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06819">
        <property type="entry name" value="PLPDE_III_LS_D-TA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="3">
        <location>
            <begin position="263"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="367" mass="40033" checksum="2B06087365F7C35B" modified="2018-10-10" version="1">MYCPSVGDRLESLDTPSMIVDLDLMESNIKKLFTTLQSTNCNIRPHLKTTKSVVLARKLEAAGAKGCCVAKVSEAEIVAAAGFDDILITCEIIGKPKVKRLVELFKQHKAIRIVVDSEAGATAINDELAQSGVSEPIAVLIDLDVGLGRTGVAAGNPALALAQHLATLPHMRLIGVQGYEGHLQHLHDRHDRKTQCLQSMKILVNTAEMLRQEDFNIEVVTTGGTGTAEFCATVPGVTELQPGSFIFMDTDYRNAVGTFYSNSLTLLSTVISKQGDRQVTIDAGLKSLTTDSGLAECKDSRYKHQNLGDEHGSLSWEDGVPNLEIGDRAEMIPSHIDPTINLHDFYYAYRNGVIEEIWSVDTRGRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6I8</accession>
    <name>A0A317X6I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_572500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470716.1">
        <property type="nucleotide sequence ID" value="XM_025614926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6I8"/>
    <dbReference type="GeneID" id="37117069"/>
    <dbReference type="OrthoDB" id="4510967at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="320" mass="36971" checksum="7CF9AD384471FADD" modified="2018-10-10" version="1">MPPNAEPSDNPRDQEAPSDRTEVCNQHNYPGIGYTNRCVLNIQKSDAFLASCLGLKWTTDVYALYHEDPVTKPQFDKWLKYRAYLKKLFNLARPPNIHGIDLFKHYQDPQFKPLLNNIYPARVEKTSENLVNRTNIVSLGTLWYIYQLVKGKRDLFPRSRVTDTGTVTELDPYDLLHAWKLLSGKMYHQKQRNVQPKKAQELEWCTCKLHPANEGRPVVKSPDSGVSGAESVRDETDVGTDTNYGYTTEEMYEADDEVESSQEPPSEDETWNEMTDVEIFGTVEQGEDLWNEEENRELFGTDEESDLWDEKANNELFDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6Z0</accession>
    <name>A0A317X6Z0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 21">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO94DRAFT_620894</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.</text>
    </comment>
    <comment type="function">
        <text evidence="21">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 21">Preautophagosomal structure membrane</location>
            <topology evidence="3 21">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471147.1">
        <property type="nucleotide sequence ID" value="XM_025616963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6Z0"/>
    <dbReference type="STRING" id="1450535.A0A317X6Z0"/>
    <dbReference type="GeneID" id="37119106"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 21" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 21" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="543"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="580"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="797"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PWY94386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="949" mass="107540" checksum="76908D6815F57C0D" modified="2018-10-10" version="1">MMTSNLLSRFLPPNGSPSVYETIRQHDSHSDSSDIEERAGMTLDDDPRDRFSDRELEDALADAGRDDSPGPSDPFLPSRSPPRTRDDEGFLKAGSRRRKFSRSARIHARSPRHKLDDSDDDVPASLLVEGGQDDDDDLVSKLPPPPSTHDHPNTALPLRSSPREDRARWEATRERLPLHNTNRKGHQGTLWSAGYPNLATVDPKEKAMWMWANVENLDNFLKDVYTYYLGNGIWSILLNRVLSLLTFGFVVGFSIFLTNCIDYRKVRGSRTLDDILIQRCTKQMSMSATLLLWLLSFFWIGKAFQYLLDIRRLKHMHDFYHYLLGISDAEIQTISWQEVVSRLMTLRDSNPATAGTVSAKLRKFMGSQSKQRMDAHDIANRLMRKENYLIALVNKDILDLTLPVPFLRNRQLFSRTLEWNINLCIMDYVFNEQGQVRTLFLKDTHRRSLSEGLRRRFMFAGIMNIFVAPFIVVYFLMHYFFRYFNEYKKNPSQIGSRQYTPLAEWKFREFNELWHLFERRVNMSYPFASRYVDQFPKDKTVQFAGFVAFVSGALASVLALASVVDPELFLGFELTHDRTVLFYLGVFGSIWAVAQGLVPEETNVFDPEYALLEVINFTHYCPSHWKGRLHSDDVRKDFAVLYQMKIVIFLEEILSMIFTPFILWFSLPKCSDRLIDFFREFTVHVDGMGYLCSFAVFDFKKGTNVISQGDTGRRDPARQDLRADYFSTKDGKMLASYYGFLDNYGANPRGAHPANKRQFHPPPTFPTLGSPSAIEMGNFGDRLDQTLLRQGPAAGLMGQQSTFGAPRFGPAGLGDHASPAPSILLDPHHQPSASGFRSTNRANPYPRYRASRPPPTISDPIEDEDPPAVQAHGAGKSPPGAGSSGGGIIRSDSNLEDSWRMNLMGEGGEDEDEGGDNVDALAGGAGVLGLIQQFQRVNKDNRGRTTVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7A1</accession>
    <name>A0A317X7A1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIE subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_531449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TFIIE beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471234.1">
        <property type="nucleotide sequence ID" value="XM_025610899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7A1"/>
    <dbReference type="STRING" id="1450535.A0A317X7A1"/>
    <dbReference type="GeneID" id="37113042"/>
    <dbReference type="OrthoDB" id="5323195at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07977">
        <property type="entry name" value="TFIIE_beta_winged_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054600">
        <property type="entry name" value="TFA2_E-tether"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22254">
        <property type="entry name" value="TFA2_E-tether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016398">
        <property type="entry name" value="TFIIE-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIE beta" evidence="9">
        <location>
            <begin position="67"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR016398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="295" mass="33382" checksum="B3ACEF726FB95984" modified="2018-10-10" version="1">MSHLQQQLKSFNAGVVDYAARMPAQRRFVHNNNNNNSASSSQLPSSTSTPTPGDEAKRKRHDADIVYSQPANTGTGKDIMTQVVFAIEHMKSKGVPLKFGDIVSYLSLQHRANDQGYVQALRSILKMHEKVQYDPSGANGEGTFSFRPPHNIRTAEQLLQKLQAQSTGAGMSVRELREGWPNVEDAINKLEKEGKLLVTRNKKDDHAKMVWANDPSLIQHFDNEFRQIWEKIKVPDQQAVKEELEKAGIVPTNKNKVVKARPKMEHKKVKKPRRSGKTTNTHMMGVLRDYSHLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7V3</accession>
    <name>A0A317X7V3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_326623</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471042.1">
        <property type="nucleotide sequence ID" value="XM_025606945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7V3"/>
    <dbReference type="STRING" id="1450535.A0A317X7V3"/>
    <dbReference type="GeneID" id="37109088"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="633" mass="70747" checksum="FC390E4B535F440E" modified="2018-10-10" version="1">MEAPRARGMGRSGPRRRTGCLTCRARKVRCDETKPTCANCTRLRLQCAYKPTSPGVVSRHTSHNVSTTTAPGHTTIAARPDVNFFHTVLCNDRISASASGSPQQAGPGRPLHSLSTDIPSFDILSFIGEITSDFQQKHLDLTTNGLAGFPAGSVPAAIANEELDQNERPIGWGSASAQVIQADTSDQGSSDTSGSRVTYEDQLFAHFVESDPPPTVFGPVTLEWEYVRANIVGQSRESREVLHGVYCYAEIHEASIQGKAWKLASKYHQLACSEVQSCLLGEVGEAMLKRVFTTVLLLMLSELLSTPDLWGSGTSFLHSAYLLLQRFQHRTKLWTGVNQVIVSWVSLLDVKALIAGRDGDPLIEMGCLSKPNITEMSTEDRPADHSSDDEPPRPAYLIREAITGPAFRFFLQTQQVIRRIVCIDLHHRSRGTVSDEFEVLQIAHQVGADLETLWNWRPRVLDVYSTPEDLFDTLQPAIAFEVCRTFRQYIANFLAIFIYLHRVAFAIYPRTDRVHRAVDRIIQLATAEVESSGSDQQHLPASFVWPLFVAGLEGSIQQRRWIVKEMQRITGTFSSRCQDPERVPGTSRTARHPHAGKALLLLEEMTRRQDASRTWADSRCVRRELFTDFFVMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7V5</accession>
    <name>A0A317X7V5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_554572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469739.1">
        <property type="nucleotide sequence ID" value="XM_025613727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7V5"/>
    <dbReference type="STRING" id="1450535.A0A317X7V5"/>
    <dbReference type="GeneID" id="37115870"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="150"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="566"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY92978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="588" mass="64061" checksum="AFF85EE0B8527F32" modified="2018-10-10" version="1">MAPSVHQVLPTSAYYAPGVLSTSSRLLHVSGQPGTIEGTAPADYNSQIHLALVNLHRVMAAVGATVRDVVKLTYYIVNYDPNNRLHTRPLQTWLAGHRPAMTLVPVPSLAVPGWLFEIEATVAVPESIPSSLSIASPTEEVDVLVIGAGLSGLMAAETVLQTGHSCLVLEGRDRVGGKTWSCPLPSGEGVIDLGAAWINDSNQSMMAELARRAGADLIEQNTTGNCLLQREDGAITVFPYGQTPRITAQMQSEMEAIRDTAEADCQAVDCSRPRDASLDSLSFLAYLHSRNASPAAIANASVWTRAMLGQEPQDVSALYFLNYCKSGGGLLQMRSDRKHGAQYLRVRQGTQIFAKTLAAALPEGTIRFGERVTAITQKERGVTLVESKGRLIKAHKVICSAPTPVLKTIRFDPPLPPKKQLLVDSFRYGYYTKVMLSFRSAWWVTRGYCGLTQSFCGPASIYRDTSSPADGKWVLTAFLAGDVGRKWSELESQREREQALLRQLGEIYGEADLPAREFIEAMGHEWSKEELSGWGCPCPALPPGVLSAAGDALREPFRDVHFVGTETAEEWKGYMEGAAVKWLTRSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7X3</accession>
    <name>A0A317X7X3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF292-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_457474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471477.1">
        <property type="nucleotide sequence ID" value="XM_025607746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7X3"/>
    <dbReference type="STRING" id="1450535.A0A317X7X3"/>
    <dbReference type="GeneID" id="37109889"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF5">
        <property type="entry name" value="IST1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="388" mass="42282" checksum="7E1818E58F17A49F" modified="2018-10-10" version="1">MPPSPQTAKLTSTLHLLIPRLRLLQKKDTASSVVQRRDLSALLAENRSTSARIRVENVIATDTAVEVMEMVELYCELLLARANVLDQAAFGEKGTRARSRARIEAQKQHAPSSSSSAMKSSGSGFSFWGFGRKDTTAATTPQSAVRDSSKGVEGEGTGSGEEEKEGYIDLALDEAAAVIFYSYPRFPHDIREMTILRGLLSDRWGKDFMMLAQENKLEDVRVPERLLKGLRVRPPTGELVESYLMEIARAYGVAWPVDTESPSRVDGDVPDLMEEGKDRNEGEGGDGDGDGGLPSTPRKIGQASESEARRASETVELNKATPPRGLFSEGKSPVSVAPPGPRTDNLNPRVKVAGEDVSRDSAQGQTRTGKSEIPELDELTQRFAALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X810</accession>
    <name>A0A317X810_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CRAL/TRIO domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_620926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471186.1">
        <property type="nucleotide sequence ID" value="XM_025616965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X810"/>
    <dbReference type="STRING" id="1450535.A0A317X810"/>
    <dbReference type="GeneID" id="37119108"/>
    <dbReference type="OrthoDB" id="43460at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052432">
        <property type="entry name" value="PITP/CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46590">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN CSR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="3">
        <location>
            <begin position="325"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="494"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="597" mass="67809" checksum="121E19B5284B8023" modified="2018-10-10" version="1">MHACSLLRRRLIPPSANSIQLALERLLHPGRAQILTPWDSNRTPLIWSRPSRRPFSTSPLSQPCESRQASSFWSVTLALLLIGTGACIQNKFRNLGGDISEVSASLEFEQESQSPFLGVIETLRTMPMEAQPGTVGNLTAEQEAKLQEFWVLLLKVCGVNMDAVEQLQQQSGDSTPSSAPQEKKKQSKRRFGLFGRSNIEEEEDTASEKSTNGITSSLASINITDGDDKYGQSKEFQQALVDMKPEEIRVTFWNMVKHDNPDSLLLRFLRARKWDVKKALIMMISTLRWRLLDVKLDEDIMKNGEQHALKQSQSSDPTEKKTGEEFLLQMRMGKSFLHGVDKLGRPICVVRVRLHKAADQDAEALDRFTVYTIESARMMLAPPVETACVVFDMTDFSLANMDYHPVKYMIKCFEANYPECLGVVLIHKAPWIFSGIWNIIKGWLDPVVASKIQFTKNVQDLEKFIPKDRIMKELDGDEDWAYQYVEPQPDENKLQEDTAKRDELVAERQQLAQELQDVTIEWISSAKKKDESTAKAVVDKRKGLIERLRAQYWELDPYARATSLYDRLDVIQGGGKIEFYPTKSKVDGNALSGEKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8X4</accession>
    <name>A0A317X8X4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate 5-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_573480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470109.1">
        <property type="nucleotide sequence ID" value="XM_025614971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8X4"/>
    <dbReference type="STRING" id="1450535.A0A317X8X4"/>
    <dbReference type="GeneID" id="37117114"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000008">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000020">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="10">
        <location>
            <begin position="304"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="419" mass="45588" checksum="D0CE23641336EC21" modified="2018-10-10" version="1">MASQRLTIVIKLGTSSIVDENTHEPILSNLTLIVETAAKLHRDGHNVVLVSSGAVGVGLRRMDVEQRPNHLPRIQALAAVGQCRLMSLWDGLFSHLRLPVAQILLTRNDIADRTQYINAQNTFAQLFDMGVIPIVNENDTLAVSEIKFGDNDTLSAITAAMVKADYLFLMTDVDCLYTTNPRNNPDARPIEVVTDISSLEADVSSAGSSLGTGGMSTKIVAAKLGISAGVTTIITKSSKPGNVHEIVKYLQQTQQGASVGPETGDYDHVSHLQTMPPLHTRFIPSETPIQSRSFWLLHGLKPRGTIYIDHGAYSALQKKAGLLPAGIVGVEGHFGQQEAVRLVVIEKVSPESLNGDFLHHGQEPKEVGRALVNYGSSEIIRIKGHRSTQIQSLLGYADSEYVALRENISFIQNDESPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9A6</accession>
    <name>A0A317X9A6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_562851</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471955.1">
        <property type="nucleotide sequence ID" value="XM_025614318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9A6"/>
    <dbReference type="GeneID" id="37116461"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="499" mass="54169" checksum="31280A352AB227A0" modified="2018-10-10" version="1">MRPGAKAGLSLRQFWIVMLGLNIGMLLAALDFNIVATAVPIISSEFNAYNNSSWLGTGFLVTFALVLPIYSKLGDIFGRRSMFMVGTIIFILGSGLCGGSKSMDMLIWSRVIQGIGGGGIYGLVNVIVTDLVPLRDVGKYVSFTGLVWAIADVAGPLLGGAFSQYVTWRWCFYINLCISPISLLITFFFLRIPSPKIDKDRIKNFDIPGTITLIGGTVCLLLAISWGGNTFAWSDSRVIGCFVGGFALLVIFVVWEHWAKDPFLPPVFLRSRAIIAIFFAEFFYGANLLGMMYYVPEFFQLVYGDSATISGVALLPMMLGLAIGNPIAGWVTSKYGLSLANAWVGSVLIVLISGLLTRWNAGTSRAEAIVELIIIGIGQGAVMEGLLVGSQFSVEPMYIGLITGLVIFTQTVGDIFGIAIFAAVYQNELRSNLGKLSLTSDQVSVILADVQKVKTEFSGTLYHSIIKVYAKSLQNGWWWLFACAACLLISSACAKQRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9Y9</accession>
    <name>A0A317X9Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_562736</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471792.1">
        <property type="nucleotide sequence ID" value="XM_025614313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9Y9"/>
    <dbReference type="STRING" id="1450535.A0A317X9Y9"/>
    <dbReference type="GeneID" id="37116456"/>
    <dbReference type="OrthoDB" id="5410178at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000475">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF157">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="55"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="511" mass="56279" checksum="69F22F0DB08D074E" modified="2018-10-10" version="1">MKPATRITTAPVESEKETLLTLLPQYGLKLAPDGLHIQWALGNCRHPRNWSLRRKVYDTTLIIFLEFFTTAISTAGSTAANHAVHEFNIPKELSIFLFVSIYLIGQAIGGVVFPPYSEVFGRKKLYVASSALYSLFCIVIASVPSLVGVVIGRLFCGFLSAIPTTVVVGSIEDIFNSRERVWVICIWTMFANLGLVVGPILSTFVVADTNWRWMFYLAAIVTGILTLLLLTLHESRPSLLLATEVSTLRKVTKIPTLEGLNPDKAPNLRSFVRIALFRPIRLLFTELIIFIVSIISAIAIALVYLFTEALPPIYQSFGFTPKQSCLPFIAIGLGLTLGLLTRCLDLRIIAHHRHQGRPLLPEDKLTGFWIGAPILAAALWLFAWTIPPAVTHLPWLISIVALVLAGYSLNEIDYVLGGYLTDSYLSYAASGLAALSLVRALLSAALPLISAPMLDRLGANFTVSVLAAVATVFCAVPPLFSRFGREIRARSAFARFSLTMYREFSVDEEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAE2</accession>
    <name>A0A317XAE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_552451</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472324.1">
        <property type="nucleotide sequence ID" value="XM_025613599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAE2"/>
    <dbReference type="STRING" id="1450535.A0A317XAE2"/>
    <dbReference type="GeneID" id="37115742"/>
    <dbReference type="OrthoDB" id="4524805at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016322115" evidence="3">
        <location>
            <begin position="17"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="388" mass="42180" checksum="18CAAA52C26610BC" modified="2018-10-10" version="1">MPYLLVFALLPRLIAAGSVFQEQPILVPRNSYPITPDVNESLLAIQIGGIVGAYVIFVAVLLSLLLFVGRRLRRAVLSSNFSLQVEMMKPMNPPPSMDPSPVTPISVNLPSPGPRSFSRSWSSLGRAPRSHISGTTSVATIDETVVASDRQRAQEDLEMLYAAVMEHDAQKEAAAAAAATARDSIPTNPFTDRASHVSSGPGSTVNNSPLSPRASSRLSRISSLSLFNLNKSHDKNQQSQPSTPNTSKLRSPRPFPLRKLSISSPVAPPPTQQTTPHSPLDTTTHPDPHGQQHGRSPSSSLPFRDAYPLQSAPATKLTVLERPLKPLNGPRTGLPTPYSPYMPFTPVTPLTPSTMITKRQRRRAEKESGLKVLNEDDLVRDDGDMWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAJ4</accession>
    <name>A0A317XAJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_280647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471413.1">
        <property type="nucleotide sequence ID" value="XM_025606623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAJ4"/>
    <dbReference type="STRING" id="1450535.A0A317XAJ4"/>
    <dbReference type="GeneID" id="37108766"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF0">
        <property type="entry name" value="DELTA(24)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="508" mass="57532" checksum="40B2359CAB89003E" modified="2018-10-10" version="1">MTTHSDRITPLCSQIAHFHHTRTPFRIYHGTTNSTRHSGFTSANSLNTAHLSHVLAVNPSTKTIQVEPNVPMDALLTATLAHNLVPLVVMEFPGITAGGGFSGTSGESSSFRHGFFDATVTQIEIILGNGEFRTASRIENAKLFHAAASAFGTMGVITMLEIQCRDAKPFVELSYLPARTIPDALQIFHEKTHDPDVDYLDGIVFSKDHVVVCAGKLSDGNTPHNHHHNIQHFTRPQDPWFYLHAQRSGQISPPANPTTDLIPLPDYLFRYDRGAFWTGRYAYNYFLTPFNRITRYLLDYFMHTRVMYHALHASGHANQYIIQDVAVPYSTAHEFLTWLDNPDNFGAYPIWLCPLKVSGDKSTSNPEIIGRGKLSPGQDDDPYLLNFGLWAPSLHRGPAFIDQNRRLEQKVRALGGKKWLYACAYYTEPEFWDIYDKRRYDALREKYHAGYLGDLYQKVRVDLDPASTDQGLGWGPWLGQLAWDIWPVSGLYGVYRAWRGGDYLLKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB21</accession>
    <name>A0A317XB21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcriptional regulator Ngg1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_530311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472346.1">
        <property type="nucleotide sequence ID" value="XM_025610652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB21"/>
    <dbReference type="STRING" id="1450535.A0A317XB21"/>
    <dbReference type="GeneID" id="37112795"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="571"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="72895" checksum="1437E1DE567D9B64" modified="2018-10-10" version="1">MPSASKGKGKGREARPSRSRNTTPNSSFSAGPTASAPLHSYLDNDASKLILTPSAIQYGELLERMGGVGPIPDSKSLELLTEHLKTLSQLAETRSDACNAGIRELSQKRKEVVEEPESAERDGSDRVKMKREADDEEEEKVLKGGKLKRRKERGSSSKEERPLAHGAHDVARQDGAETKVEGAASPASKKSKNAPSEEASSLSPPLRTSPRPAAAEAADDAGSPESDDSSESHQPEPAPAVPQVQVFGPNPLKFDDPTVYHIRDVTPNMTDEEKKVIYSVNRFPWSDLSHMMAGSPPDRDFSNAKPTNQVSANTFLAYVDPYVRPLTEEDMAFLKEKGDRATPFIMPRRGKKHYTETWAEDDGLMNVDQTNGDKERLPLNQGRGNIDQVTDETLETDKISVGPVVSRLYSLLRYEHRAPPDESTANGSVNGDVANGPMNGDSMDIDHPAGDPESKPLPSATAFPDASPNNFKVPAAKLDHAQLDERLKAELRHVGFLGADDNPDYDAHYDDDIAQRLRLLQSELKKQMIINSARKTRLLEIARERMAHQEYMTIHDDLDSQVQQAYLKRTRTLGKSKKGSQAKHRPGGAGGGSHVVSAAGVGRPAIGDVARTLMDRRKRWRDCIGPVFKDCKTSVPGKTDTVFDPSLMAEYEKAEVEGWDEEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBJ0</accession>
    <name>A0A317XBJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_139347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472640.1">
        <property type="nucleotide sequence ID" value="XM_025605715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBJ0"/>
    <dbReference type="STRING" id="1450535.A0A317XBJ0"/>
    <dbReference type="GeneID" id="37107858"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13299">
        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="67"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="288"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="402" mass="45007" checksum="0D2620CE58F69ECA" modified="2018-10-10" version="1">MSPTISTSYAPVAEGNPKAPAIQLPDGTVQRSTLLSPNSQCTSYRNGRVNLDTFSPVNENGSFEFDRVLKTGKVFRRVKHKHAFRASWKPAYLVLRPNLLSVYKDEETTRLRASITLSEVTAVASVRSPRSNRQHVFGVFSPSKNYRFQASSDKDTEDWIKQIKGETRMDEDEEAFLALSKNGDTAGNNKRRIYDTTDHSDFDHRGRPSSPEIGDSLSPTYQSKRFASPHDHSGNDITSYSEWSDGPGSNNGVRLKSPSLPNQPASVHSDGHSSVPRNESGVFRDPERVVCNGYLQCLRIKGSMRQWKRLWVVLRPKSLGFYKDEQEYSAVKVIPMAQVIDAAEVDPMSRSKYYCLQIIAEEKSYRLCTADEESLAKWLGSLKSILVARKKLEPAPGAAGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBN5</accession>
    <name>A0A317XBN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="16">ATP-PFK</shortName>
            <shortName evidence="16">Phosphofructokinase</shortName>
            <ecNumber evidence="16">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_530668</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16 17">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="16"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472690.1">
        <property type="nucleotide sequence ID" value="XM_025610723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBN5"/>
    <dbReference type="STRING" id="1450535.A0A317XBN5"/>
    <dbReference type="GeneID" id="37112866"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000010">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 16 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="16"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="405"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="16">
        <location>
            <begin position="391"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="16">
        <location>
            <begin position="405"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="117"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="207"/>
            <end position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="298"/>
            <end position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="538"/>
            <end position="542"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="576"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="583"/>
            <end position="585"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="669"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="675"/>
            <end position="678"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="750"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY95929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="784" mass="85830" checksum="47A6AD524991533C" modified="2018-10-10" version="1">MMAPPQAPVEPPKRRRIGVLTSGGDAPGMNGAVRAVVRMAIHSDCEAFAVFEGYEGLVNGGDMIRQLHWEDVRGWLSRGGTLIGSARCMTFRERPGRLQAAKNLILRGIDALVVCGGDGSLTGADVFRSEWPGLLKELVEKGELTKEQVKPYQILNIVGLVGSIDNDMSGTDATIGCYSSLTRICDAVDDVFDTAFSHQRGFVIEVMGRHCGWLALMAAISTGADWLFVPEMPPKDGWEDDMCAIITKNRKERGKRRTIVIVAEGAQDRNLNKISSSKVKDILTERLNLDTRVTVLGHTQRGGAACAYDRWLSTLQGVEAVRAVLDMKPESPSPVITIRENKILRMPLMEAVQHTQTVTKHIQAKEFDQAMALRDSEFKEYHFSYINTSTPDHPKLLLPENKRMRIGIIHVGAPAGGMNQATRAAVAYCLTRGHTPLAIHNGFPGLCRHHDDTPVCSVREVAWEESDSWVNEGGSDIGTNRGLPGDDLESTAKCFKKFGFDALFVVGGFEAFTAVSQLRQAREKYPAFKIPMTVLPATISNNVPGTEYSLGSDTCLNTLIDFCDAIRQSASSSRRRVFVIETQGGKSGYIATTAGLSVGAVAVYIPEEGIDIKMLARDIDFLRDNFARDKGANRAGKIILRNECASSTYTTQVVADMIKEEAKGRFESRAAVPGHFQQGGKPSPMDRIRALRMATKCMLHLESYAGKTADQIAADEMSASVIGIKGSQVLFSAMGGADGLEATETDWARRRPKTEFWLELQDTVNILSGRASARDAAWTCYERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC50</accession>
    <name>A0A317XC50_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GTP:AMP phosphotransferase, mitochondrial</fullName>
            <ecNumber evidence="7">2.7.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenylate kinase 3</fullName>
            <shortName evidence="7">AK 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ADK2</name>
        <name evidence="10" type="ORF">BO94DRAFT_562334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a ribonucleoside 5'-triphosphate + AMP = a ribonucleoside 5'-diphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:13749"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.10" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC50"/>
    <dbReference type="STRING" id="1450535.A0A317XC50"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046899">
        <property type="term" value="F:nucleoside triphosphate adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046039">
        <property type="term" value="P:GTP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046041">
        <property type="term" value="P:ITP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03169">
        <property type="entry name" value="Adenylate_kinase_AK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028586">
        <property type="entry name" value="AK3/Ak4_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="69"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="108"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="234" mass="25790" checksum="492836090C23F8F2" modified="2018-10-10" version="1">MTATIRQLKKAARIILIGAPGVGKGTQTERLLARFPELASISSGDLLRENVRNKTPLGLKAEAAMQSGNLVPDSMILDLISSEFKSRGWLSAAPTSSITPSASFILDGFPRTATQASSLEPIVPVNFVVHLVTPPSVILSRIASRWVHEPSGRVYNTDFNAPKVPGKDDITGEPLTQRDDDSIDTWTQRLNKFEETSKALLEHYQRKGCLWRVEGDTSDEISPKLFSEIERQFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC65</accession>
    <name>A0A317XC65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_542844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471319.1">
        <property type="nucleotide sequence ID" value="XM_025613110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC65"/>
    <dbReference type="STRING" id="1450535.A0A317XC65"/>
    <dbReference type="GeneID" id="37115253"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="9"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19344" checksum="C527E2EA45A2288F" modified="2018-10-10" version="1">MNPETTQPYTLRHHRPGDIGWIIHRHGILYAQEYGWTERFEALVAGVTVDFIEHYDTTCERCWIAERDGEFLGCVMLVKDRTCDCGNTAKLRLLLVEPSARGLGLGRALIRQCTEFAREAGYARIQLWTNGVLASARRLYEREGYRLVSSEADDKLGFQSVGEYWELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCI0</accession>
    <name>A0A317XCI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_505500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473095.1">
        <property type="nucleotide sequence ID" value="XM_025609547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCI0"/>
    <dbReference type="STRING" id="1450535.A0A317XCI0"/>
    <dbReference type="GeneID" id="37111690"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000252">
        <property type="entry name" value="tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="120"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY96334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="459" mass="50348" checksum="C92943ED3AF4637D" modified="2018-10-10" version="1">MLSKFSTSALRKSLCNASRWNSRPRSRGLLTLAIETSCDDTSVAIVEKEANAVQIHFLDKITCDTSAYQGIHPVVALESHQENIASLVNKALAHLPVACETKHGRHQTINVSNSSELRRKPDLVCATRGPGFRSNLFVGLDTGKALSVGWQVPFVGVHHMQAHLLTPRLVSCLNRGQDSSSDVALSQPVTPEFPFLSILISGGHSMLVKSSSITDHEIMASTVDRALGEAIDKAARDIIPSDLLQTSKTTMYGKLLEQFAFPNGSADYADYQAPKSRGEELVPRENSWGWSFTEPWSHSRQLQFSFCFIGTTLARIFAAKEASGQAISYDERMALAREIMRSSFEHLASRTIMALESLVKKGTDKEIETLVVSGGVAANQYLMTVLRSFLDVRGFGHVGIVAPPPYLCTDNAAMIGWAGIEMFEAGWHTNLTSRALRKWTLDPREADGGVLGPFGWERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCW2</accession>
    <name>A0A317XCW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_531722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471549.1">
        <property type="nucleotide sequence ID" value="XM_025610963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCW2"/>
    <dbReference type="GeneID" id="37113106"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="103" mass="11665" checksum="EA47E1D5B79C436D" modified="2018-10-10" version="1" fragment="single">MPGCTTRPFTGLRSYNGAGSVNIVVIITYAKLPLCKNPDCSGRRMNRWQWRPTAGFFRPTCRLPHAWLVSQPGIGTPYLDGRNEVMTFGATIKTNIRYNMREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD63</accession>
    <name>A0A317XD63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_3982</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473026.1">
        <property type="nucleotide sequence ID" value="XM_025607381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD63"/>
    <dbReference type="GeneID" id="37109524"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY96265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="95" mass="10718" checksum="D8F709470CE70817" modified="2018-10-10" version="1">MSTITTLHAIYTSPQQTHTFEHPITTTHPTSVATKVTYLAELRKLVPNIQNDINVFLTERMEEDKKAAEAQGQAVSDKEVKEEENYGEEVVEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD82</accession>
    <name>A0A317XD82_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_580844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472433.1">
        <property type="nucleotide sequence ID" value="XM_025615351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD82"/>
    <dbReference type="STRING" id="1450535.A0A317XD82"/>
    <dbReference type="GeneID" id="37117494"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209">
        <property type="entry name" value="AGL056WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48209:SF2">
        <property type="entry name" value="FI24008P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="7"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="578" mass="66173" checksum="4D3CE9AA60DFCACB" modified="2018-10-10" version="1">MPSRIINYYSILGISHNASLKDINSAYKRLALKYHPDKKTATTSEDPSTDEFQKIQQAIEILRDPILKQAHDSSLHQQGYLFSDFPDDDYNDEDYPPGSTWRPTEGSRYDLRDPRERYMYSYGNSVHMDPFSADSLAEKARVQVEIRVGEMLRREAEMREAAEAAAAAAASREEGDGDYEDDDDDDDDDDDDDDDDDDDEYVEEEWIGFDWDDRPKTYEEFLEYLKNEEEGKEERRKAAMRANVERDEEVLKSGEDEEGNEDGDLKEFAKGYDFGYCWRSKEAGLSVPREYHDDFYSNGEDDQGVDWDREYVEEEMKEDEEQDNDDSDKQEERRRRPRRTLPGPQLPNPPPDASYHSDSDSYNYYDDDDDEYDDAGNDCADLYYYEDAAEQATDEQSSSEYLTARQSSEASPTRSGVSVHRPSIGGGGSSIFYDLCEQDLTLLSFSDEPSKKSTSGVDLTLAPDYLAPFIPHFQNKLSHPSGRYTAQDFLNEVTGMILEIYCGWLESVRLTMPEAKSLQEGQDPQHCRHLGCWEKHFNRAVCDECHLWQPIYTLTCPGCGTGACVGCKFSGCCVRQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD85</accession>
    <name>A0A317XD85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_484593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471261.1">
        <property type="nucleotide sequence ID" value="XM_025608963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD85"/>
    <dbReference type="STRING" id="1450535.A0A317XD85"/>
    <dbReference type="GeneID" id="37111106"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="198" mass="22704" checksum="E420625DE94A8AE2" modified="2018-10-10" version="1">MNPLTTFVKRHLTGEFEKKYIATLGVEVHPLAFHTNLGNIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCEGIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPQLEFVAAPALAPPEVAVNKELMEQYEQEMQAATQMPLPDEEDPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDC3</accession>
    <name>A0A317XDC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_530791</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471659.1">
        <property type="nucleotide sequence ID" value="XM_025610753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDC3"/>
    <dbReference type="STRING" id="1450535.A0A317XDC3"/>
    <dbReference type="GeneID" id="37112896"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY94898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="448" mass="50145" checksum="BE284B742AA6DAE4" modified="2018-10-10" version="1">MREVISLNVGQAGCQIANSCWELYCLEHGIQADGYLTEERKKDDPDHGFSTFFSETGQGKYVPRTIYADLEPNVVDEVRTGTYRSLFHPENMITGKEDASNNYARGHYTVGKEMIDQVLDKVRRVADNCAGLQGFLVFHSFGGGTGSGFGALLMERLSVDYGKKSKLEFCVYPAPQNATSVVEPYNSILTTHTTLEHSDCSFMVDNEAIYDICRRNLGIERPSYENLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPYPRIHFPLVAYAPVISAAKASHESNSVSEITMSCFEPNNQMVKCDPRNGKYMATCLLYRGDVVPKETHAAVATLKTKRTIQFVDWCPTGFKIGICYQPPQQVPNGDLAELKRAVCMLSNTTAISEAWSALDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVASDSLEDEVEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDZ7</accession>
    <name>A0A317XDZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_530709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472733.1">
        <property type="nucleotide sequence ID" value="XM_025610728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDZ7"/>
    <dbReference type="GeneID" id="37112871"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="60" mass="6592" checksum="108688DCF03918EA" modified="2018-10-10" version="1">MREIAMVENSDESQSGYVIVGVVKSLSRSFSILVITSLYLRNTTLCLPRADSKPDGKDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEI7</accession>
    <name>A0A317XEI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_18922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473516.1">
        <property type="nucleotide sequence ID" value="XM_025606032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEI7"/>
    <dbReference type="STRING" id="1450535.A0A317XEI7"/>
    <dbReference type="GeneID" id="37108175"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="146" mass="16607" checksum="C0C70B74F23F22F7" modified="2018-10-10" version="1">MSHKLFILVYRGDPLDYSEYRHTALYVQFAAQGRSVLHIIGTQGLFRYVEYVGADPMELGDLVRVVPVTDLSGSVEAEEEAIRETVARTPVRNGYLDLEWNCQHWVGDALGRLVERGWVTEEERAEAIDKMTDACLEARDDQFVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEJ7</accession>
    <name>A0A317XEJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_620382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472838.1">
        <property type="nucleotide sequence ID" value="XM_025616928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEJ7"/>
    <dbReference type="STRING" id="1450535.A0A317XEJ7"/>
    <dbReference type="GeneID" id="37119071"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY96077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="421" mass="46843" checksum="E22C2D39A56A3A81" modified="2018-10-10" version="1">MAPKADVQVLIIGGGIAGLTLANICKRIGLTYKVLERTAEVTPVGAGISLAPNALRLLDQLGFMDMIRKEGQPLRKIQVFRNTTKWSVLDFEWLEGTYGYSMYSMPRHSLHRALYQATGTEHVILDAEVVSFEDDASSPVVKVRLADGREFSGEVLVGADGIRSITRRLLADKQGLAGVNTIRFTGRTHMTGISYPLTHRGPEDLGVATWVFYDDCILTSWPCIENRQWFVGVKQSEAKTITRSTWKGATKEMINEVYGHRFHPMGKNGTVRDVVDIAERVTASDVFEETAFPEMAFGRVALVGDSAHSMTSFIGQGACQAIEDVGELANGLHTYFAGQSNDPQVLRNVLVDYRKSREPRARNLVYYSSIFAQVHTGRLPYGLGPIARRIAFSYAPTWCWKWATDPLYGYQPRVHALDMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XET8</accession>
    <name>A0A317XET8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_620619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471901.1">
        <property type="nucleotide sequence ID" value="XM_025616941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XET8"/>
    <dbReference type="STRING" id="1450535.A0A317XET8"/>
    <dbReference type="GeneID" id="37119084"/>
    <dbReference type="OrthoDB" id="2015405at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050268">
        <property type="entry name" value="NADH-dep_flavin_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466">
        <property type="entry name" value="FLAVIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30466:SF1">
        <property type="entry name" value="FMN REDUCTASE (NADH) RUTF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="3">
        <location>
            <begin position="77"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="270" mass="29514" checksum="B7C9602F3E936B41" modified="2018-10-10" version="1">MLPYSRAMLAVSRTASHCTGQCAPLIRTALRSGLLQSRRTVTNFAPNTKIPSQSDSAGAQHAKNETPSVSDQVRLLMRRVPYPVAIITATDPHGPADKAFRGMTVSSFNTVTLSPEPVISFNVRRPSETLSALQSSKRFLIHLLAPRQATATLARDFSRGNHNLSLLAGKSDYEFVSHDHSIRGDETPTRPLPLLQRKQGSGSADSEDFPFVLECQLHPQGIQVHDHTIVVGTVVRALSGQLPSLDSETKAADLCLTYANTHFWEMGHEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEY3</accession>
    <name>A0A317XEY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_529655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473028.1">
        <property type="nucleotide sequence ID" value="XM_025610495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEY3"/>
    <dbReference type="STRING" id="1450535.A0A317XEY3"/>
    <dbReference type="GeneID" id="37112638"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF1">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05752)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="734"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="956" mass="107271" checksum="A513A60D419F1BEE" modified="2018-10-10" version="1">MADASAPASSAPESKLDADPPTTDSPPVISDPKAPPAPITEPVAKKSVCSKHPTKEQDPNRSTKKKKAHRKASSIVTPSDDSSPEINSTTDESNPDSASDGEATQSSSESASDRKQRRRRAKNKAKKALKGGRKKKSRSHQTDSDSTSDDEDSDDSDSTLDEKTLKKLVAKLKAKKNAKKSRSKQDSSEELPDEDDGDDDDDDADAEELALLLAKQKLATLRIKLADGRRKGRGKRGLNDGLTESQKGSSQKTKGRKKAASKIAFKRVDQLWDNTIHNFKLTETVDDPDANEWDQYLFTVRRKFDWDNKYLETVVDLKSKYLRDALAKVMDGVKGVSLVQETAVVDPNMLFLYLEETRQYMKDLAQLAKAEKKRKARKVAELKASHLKVLIKYLDTDYAETKKTLYPLLDANMITFDLLWAIFKPNTVAYSSTYGNQDEPRAFKIEYATKESSFMKGQWYSIEGRYLEYDGKAFGMGTMAAEVESFKGARKITSLSCYPLKYHREAESVKAKLIERGKKFVALRGMNYRFHKGMAFYKKKRSVIKVNINGRVMIDPAIHRRINPNYPISTVRPKDPDYLDGSDNDGSDDGCCCAMSDSDSEQAFGQLRDSDAPQVRYKVVRDKEGKPHVVEVELDENGNEIRKEDMDEVEDPSDRDFTEEELLIASPVVLGFAFSEKLWLEFSISGISDIEWNEDAFDSLVLPDNQKSIVKALVESHTFRAAQNIDDVIQGKGKGLVAVLHGPPGTGKTLTAEGIAELLKRPLYMVSAGELGTDSRTLEGELNKILDIAHSWGAVLLLDEADIFLEKRTIQDIHRNALVSIFLRLLEYFQGILFLTTNRVETFDDAFQSRIHVALRYGDLTTKAKRSVWKMFLERVQAMEGVQTATFTEKDFDLLARHNLNGRQIKNSVRTAQALAVNEQNPLSMEHIKRVLEVAQTFDHDLRGGTGYLDAMRSYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UX00</accession>
    <name>A0A317UX00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_540732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461556.1">
        <property type="nucleotide sequence ID" value="XM_025612980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UX00"/>
    <dbReference type="STRING" id="1450535.A0A317UX00"/>
    <dbReference type="GeneID" id="37115123"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="378"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY66046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="501" mass="53951" checksum="61BCFB4304A4FD71" modified="2018-10-10" version="1">MAAAGVSQATSPRLPSPPPFTEVQIGPKSPSVGESFDHETERLLGASQISEDGSTRRIRPGTRAVDMAFGPPLIPLSQLDSPFQLQEHLKALYNHYTRPEGTDTVVPISREVAIQLAEPPDGVDRSLWLYELCRFLTMKVNNLLIAFFADSPPCSAQTCPEMRASEWQYLCAVHDPPKSCCAIDYCCHTLDWATNILTSPKYFPSRLTLGSETGGGAQASMRHLTNIFRRLYRIFAHAWFQHREVFWQVEGHDGLYVFFKTVCDMYSLIPEDNYTVPAEAEGVDVQQPPALEHTDKRRMTILRKDNESFAASLENMESASISTGATTRRHKNSPSVSSSVTTISEGAEDDEHPRQQAVAAATAAVAAANAAAAASSPVAASSAPAPAPAPEPESEPEPTPEAASEEQTSQPEPSADSNGSKITVSEVHAEDDEAAPESTGKPEPAEPETKVEADEPAAEAEGEASAEAAEATEATKPEEESDVKQPSSQEPPAENEAAQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYG9</accession>
    <name>A0A317UYG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_628952</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461826.1">
        <property type="nucleotide sequence ID" value="XM_025617521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYG9"/>
    <dbReference type="STRING" id="1450535.A0A317UYG9"/>
    <dbReference type="GeneID" id="37119664"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF11">
        <property type="entry name" value="ISOFLAVONE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G12510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY67104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="319" mass="35049" checksum="956B0018D02726E4" modified="2018-10-10" version="1">MSHKSNLLIFGATGSIGQYITDAIVSAQDSFGRISIFTSPNTLTNKPDEINALRHRGVDILVGDITNRDEVLKAYGGVDTIISALGRGAIAAQIPLIQLANETPHIKRFLPSEYGTDIEYSPASQHEKPHQQKLKVRAALKEVRSDLEYAYVVTGPYADFPFYLGRSNFAKGGTFDAVAKKAVLLGDGQGRISLTACADVGKFVVHALTHWDAARNRALKVNSFTTTPAEILTLFENQTASDWTVEYTSLDELRAFEKEAWDKGAPEATLYTLRRIWTEGGTLYERRDNEDIGVTETTTLSELVKDSVQKQVEAGAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYU7</accession>
    <name>A0A317UYU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0016-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_612174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461888.1">
        <property type="nucleotide sequence ID" value="XM_025616658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYU7"/>
    <dbReference type="STRING" id="1450535.A0A317UYU7"/>
    <dbReference type="GeneID" id="37118801"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016375069" evidence="8">
        <location>
            <begin position="24"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY67244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="515" mass="54960" checksum="591F864825BD912B" modified="2018-10-10" version="1">MKIHHLSSPLLLLLLPALSTALADPSSANNSVKDTPLAEREALAPGAVELDAVTAPKSAKGTLDAPIDGKDGRPHAGPWVETSAERDRKKTGSSTWSEEKSKSDPKAAEQLGPDGSPIPYSNDGVMDDPHRTGPKEGTRGTEGGVSEKLREPYSNEKTPGSPKEAPPLPHSESQKLPVSDEDSEVKDTKSPSADSNLGKLEKPADLPDKPHDIPPPKSPSTVKDSPLGLDKHGSTQPGESLAEGTAFHSLLFSFTMIIVSEIGDKTFLVAALMAMRHPRLLVFSAAFSALIFMTVLSAVLGHAVPTLIPKSVTKLLAAVLFLVFGLKMLKEGREMSPDEGVGEEMKEVEMELEEKEQEQRRMSRRSSVTPHSLEAGRVGRRKSRSSGNRLPSPPESVSSSSSRGSSPSRNRWGDLLVGMNNLFSLLLSPAWVQTFVMTFLGEWGDRSQIATIAMAAGQDYWWVTIGAITGHGLCTAAAVIGGSAIAGKVSMRVVTLGGATAFLVFGVIYMFEAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZM2</accession>
    <name>A0A317UZM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461858.1">
        <property type="nucleotide sequence ID" value="XM_025612938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZM2"/>
    <dbReference type="GeneID" id="37115081"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="83" mass="9999" checksum="F395EFFC8A929137" modified="2018-10-10" version="1">MMDTPRNLRPDLLNYQIYIRFRSDDRVRWWMSSPSPRPRPRPRLRLRLRVGLRLRLRWCAVGGFMWCGIVLMVSVCRLIGVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4G3</accession>
    <name>A0A317V4G3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_569944</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY67968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462017.1">
        <property type="nucleotide sequence ID" value="XM_025614765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4G3"/>
    <dbReference type="STRING" id="1450535.A0A317V4G3"/>
    <dbReference type="GeneID" id="37116908"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="519"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY67968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="987" mass="108982" checksum="13FBCE4B213C558D" modified="2018-10-10" version="1">MDHHFSQHAATNPDAIAIDDETRQWSYSDLDHEVQQVTNVLKKLDLPPEEPICILEGVGSDTIIAQLAIIRAGLTCVPIEPSIPPIRLMSLLKDVGVRYIMSNQSPDLEDDVVIIPISGEYDPKNIPSKSKTNGVNGAQVNGSNNQTRGYRSHILYTSGSSGKPKAVQIAETSILHIAFETAATPLESSDRVAVVNNPGFDISLFEIFVPLVAGSTLVIVPRSTIMDPFDARDFLARKNVSILVLTASLLSIIAQVCPTAFGGIKHLFSAGEAPNPSSIKAILESNNSPQHVWNTYGPTEATTLSTMHEITPKDLQYENISIGKPFGDTILQLFDEHSNPITKPGVIGEILLGGPGLTAGYIARPKENEEHFTTDKAGSRLYRTGDFARWRPDAPDLLEFMGRADLQVKQGGFRVELGEIEQLFLSSGQLVGATVVQIQPDTPEDEPFLVAFLIPAVANTVRRRQMLEYIQPRVPNYSIPRDIVVCSDYPLTEHGKVDRKALTKQYQDQHPQSHSNDTSPSNDTTTTLKNIWTSILGQHDIADSDDFFSTHRGSSLQAATLISKIQQELRKTISMRSLYENSRLSDLVACLDEYTEGGNAPDDRTHWLQDATLANDLHPVPDWLAPDEGRIFLTGATGFVGAHFLARFLQMPSIKEIVCLTRSKPNQPPPSERIQSVLQRYNLWSASSPTINKLTVLTGDITSPQFGLSSESFTWLTNWSSIVFHLAAKVNFCEPYAAHQPSNVLGTRHALEVAIRGRRKPFIHMSSIDTWGPSGLVLGTKTLLEDDPLDPHLRGLPFDIGYAASKWVAEKLVRGVRTRGVPAMIFRPGFTIGDSVTGSGNPDDFFARLIIGSIMLGAFPHLPNQRLEYVTIDYVCDATIHIASNNANLGRSYSLVAPDPKDSVNLDDTHKVINEAGYPVKLLPYWEWAKQDNPLLGPVLGRLSRFETSRNTPHYDARNTGVGYVSFDAAMLKRFVEFWEKKGFYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V545</accession>
    <name>A0A317V545_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_478676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY67962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462011.1">
        <property type="nucleotide sequence ID" value="XM_025608702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V545"/>
    <dbReference type="GeneID" id="37110845"/>
    <dbReference type="OrthoDB" id="4502630at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY67962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="230" mass="26490" checksum="E9F0CD08FB5F4875" modified="2018-10-10" version="1" fragment="single">PRAERDLIASLDGFCVQDDFDVVVTGLPKPLQCICLQTLVGTLLAKECMVRFFMNAFWYLVPQPTSDAGEEKPPINTAGFEDQILTLYRNMLDSNPSDAHHWRIWTTRFSNADNAFGNNMAAHRKSMVDRICEEIFGQELLQSLLRNSDQNSRDQALGELKEHFNFASDLSVRISAKLQYLHNHQLNGRRILYMQSPAIWVCERYDIFRRRSLERPATVYVEDRESPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5B1</accession>
    <name>A0A317V5B1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_540271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462099.1">
        <property type="nucleotide sequence ID" value="XM_025612882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5B1"/>
    <dbReference type="STRING" id="1450535.A0A317V5B1"/>
    <dbReference type="GeneID" id="37115025"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE ACA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY68077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="218" mass="24618" checksum="BCF2C8A870695213" modified="2018-10-10" version="1">MPALLEDPTTHIPPPLPPQISHSHLHPQNPPRRYQNHPLPHNHRPIFPPSSLTHYLHEQFSLEIEKGCTYPMESPMEYDLYRSYWFGTFAVVAVVDEDQTQDDGLREGRNWEECCLGTFYVKPNYPGRCSHVCNGGFFTTPAARNRGVGRVMGEGYLEVAPKLGYKYSVFNLVFENNVASVKIWEKLGFQTIGRVPGAARLANSPDLVDALIIGRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8H9</accession>
    <name>A0A317V8H9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_477312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462656.1">
        <property type="nucleotide sequence ID" value="XM_025608637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8H9"/>
    <dbReference type="STRING" id="1450535.A0A317V8H9"/>
    <dbReference type="GeneID" id="37110780"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="288"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="332"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="415"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="457"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY70365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="601" mass="67028" checksum="8CF51C03CF82C0C1" modified="2018-10-10" version="1">MGDPQKSDRPATRNTAAAASAAKSPERVAPNALTIASPPGSRTPPSMPSKKTLFYPEPQGRRQKARNTSESIDPDALAKALQDFEDAGHPRERTPGTSPSRKRQRVYGDRFIPNREGQDLQATYSLLHEDGCPSTPSKLKKRAPHSELHFQKTEEANRMYSRVLRSELFGNTVPQADLDSLSPDPLMGMGNGIIDKTRSHTPPSHVVSNLPPASITPSTPHKNLFNYASPRGSAHPTPSKTPRSQHGPNLNVRSELYSLSPIRLDSQRILETPRKQPRYVNKVPYKVLDAPDLQDDFYLNLVDWGSSNVLGVGLGNSVYMWNSQTGRVTKLCELRDDTVTSVSWIQRGTHLAIGTGKGLVQIWDAERCRRLRTMIGHTNRVGALAWNDHILTSGSRDRLIFHRDVRSPDQYLRRLSGHKQEVCGLRWNTEDGQLASGGNDNKLLVWDKLNETPLYRFSDHTAAVKAIAWSPHQHHLLASGGGTADRTIKFWNTSTGSMIKEVDTGSQVCNLAWSKNSDEIISTHGYSQNQIVVWKYPRMEQIVSLTGHTFRVLYLAMSPDGQTVVTGAGDETLRFWKIFNKRPGREHGREGSKLAEWGTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9S3</accession>
    <name>A0A317V9S3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_262957</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462829.1">
        <property type="nucleotide sequence ID" value="XM_025606506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9S3"/>
    <dbReference type="STRING" id="1450535.A0A317V9S3"/>
    <dbReference type="GeneID" id="37108649"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="18">
        <location>
            <begin position="73"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY71074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="423" mass="45443" checksum="8D70F213CE4E8184" modified="2018-10-10" version="1">MDDHSRIYISTAFVAGVLLTLGFKDLVYPELERRIRDYYQTDSQSKSATTSTDLSEDVLSARTGPPAIVEGIEGCIGNTPLFRIKSLSDATGCEILGKAEFLNGAGQSSKDRVALSMIQIAEQHGILKPRSGDTIYEGTSGSTGISLATLARAKGYLAHICMPSDQAIEKSNLLLKLGAIVDRVPPAPIVEKDNFVNRARALAQAQTASTTDGRGFFADQFENESNWRAHFNGTGPEIYAQCNGKLDAFVAGAGTGGTISGVALFLKPKIPNLHVVLADPQGSGLYNRVRFGVMFDYKEKEGTRRRRQVDTIVEGIGINRVTANFEAGKELVNDAERVTDAQALAMARWLVEKDGIFVGSSSAVNCFAAVKTALKLGPGHRIVTVLSDSGSRHLSRFWAKAGDVGGAVDTKLEDVLNAKEDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VD49</accession>
    <name>A0A317VD49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 21 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_628380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462508.1">
        <property type="nucleotide sequence ID" value="XM_025617480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VD49"/>
    <dbReference type="STRING" id="1450535.A0A317VD49"/>
    <dbReference type="GeneID" id="37119623"/>
    <dbReference type="OrthoDB" id="196140at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053229">
        <property type="entry name" value="NADH-Q_oxidrdct_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024549">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019721">
        <property type="entry name" value="NADH-UbQ_OxRdtase_su21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062:SF1">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 21KDA SUBUNIT N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34062">
        <property type="entry name" value="OXIDOREDUCTASE 21 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10785">
        <property type="entry name" value="NADH-u_ox-rdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12853">
        <property type="entry name" value="NADH_u_ox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 21kDa subunit C-terminal fungi" evidence="3">
        <location>
            <begin position="111"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY69810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="191" mass="21376" checksum="43BB39EA9705EBDD" modified="2018-10-10" version="1">MATDNKTIVVPPKRANTDYPLIDSDPHLRRVFGYARPSDYAVGGGMAAASPLAFWVMERVSPSHVGRGGFAPVMRLATAIGLIGGLHVVYQRSCNRFYGFTENSREVDMDMKEMVEKVKKGEPIYGTSKVSAYLQGVAARNSRYSELFIHVLPWFNLVNHDQYKHGVDTAKYYQQAERELEAERLKQAGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VE56</accession>
    <name>A0A317VE56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0220-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_539498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462949.1">
        <property type="nucleotide sequence ID" value="XM_025612713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VE56"/>
    <dbReference type="STRING" id="1450535.A0A317VE56"/>
    <dbReference type="GeneID" id="37114856"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY71551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="173" mass="18996" checksum="62986A2D791BDC36" modified="2018-10-10" version="1">MDVSNNRLFRWSKPEWLNNSAVRNAGVYTSGALFSLGFFFLIDAAAFSHSSRNGSFVHVKFVDWIPGICSALGMLVINSIEKSRLHADSFSYSGSGVAWKARFVLFLGFALLAGGLAGSVTVMVLKYLMKGYPLPTLYFGIANVLANGLVMMSTVVLWISQNIEDDYTYNLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VG65</accession>
    <name>A0A317VG65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_550158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463104.1">
        <property type="nucleotide sequence ID" value="XM_025613481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VG65"/>
    <dbReference type="STRING" id="1450535.A0A317VG65"/>
    <dbReference type="GeneID" id="37115624"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF17">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="128"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY72151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="376" mass="41204" checksum="1F2C5A8343EA9DAE" modified="2018-10-10" version="1">MATLRPILVKSWYLATLPFRILGICLYYSIPFARPYPGWTYHQAIGLKLFDLWWRYSLATDFHAHKTLFPGDEKDRFIVMQPAPSTKTRNYYRGILLTNPAIRPLPIGAVWYSTAPTSPKGPFPDGIVLHFHGGAYVMGGARPPEGGWGPDQLSGILNKPVLQVQYRLAGPTPAASTHTCFPAALQDAITAYAYVLDVLRVSPQKLIISGDSAGASLALTVLRYLATESKTDGNHHLPLPLPRAAFLWSPWLDLSPTTAAKINHHRNARSDYLTGSLAEWGASCYAPIEENAREQAWLSPLGREFPTISTGIFVQTGTAEVMVDENLQIVEEMKSIGNTAKAWVVEGATHNIFAAGQILGMMDEARGAMRMAGGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJW2</accession>
    <name>A0A317VJW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_252171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463143.1">
        <property type="nucleotide sequence ID" value="XM_025606439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJW2"/>
    <dbReference type="GeneID" id="37108582"/>
    <dbReference type="OrthoDB" id="4154127at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="98" mass="11267" checksum="11C8DB9E6BB7F1CC" modified="2018-10-10" version="1">MDCFRQIARLVKSPFRREKQQKVLEIGPPTDFRKEELPAFFTDDDAATLHSRGSTLDKEKEAAATAMERQPSTRDKIKTHVRRLSVRVARPLSNADEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJW8</accession>
    <name>A0A317VJW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin synthase export chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_240989</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CHS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463417.1">
        <property type="nucleotide sequence ID" value="XM_025606369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJW8"/>
    <dbReference type="STRING" id="1450535.A0A317VJW8"/>
    <dbReference type="GeneID" id="37108512"/>
    <dbReference type="OrthoDB" id="2189463at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF2">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="221"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY73152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="331" mass="36447" checksum="94B52D479C6918FA" modified="2018-10-10" version="1">MGFGDFDSICEKAPLPLCSLVGPPSSISGSTGIIPNCYARNIELANTIIFEGASCFLHIIALGMTVIMILHVRSKFTAVGRKEIITFFYIYMTLTICSLILDAGVAPPGSGPFPYFAAVQNGLASALCTSLLINGFVGFQLYEDGTILSVWLLRLSSAAMFAISFLVSLATFKAWGGLGPTNTVGMFVVLYVLNAICIAVYLVMSLLLVMNTLEDRWPLGHIAFGLVVFICGQVLLYAFSDTICNSVQHYLDGLFFATFCNLLAVMMVYKFWDYITKEDLEFSVGIKPNTWEVKELLPDEDRRQTGYPDASSEYAGSMYHHRTSTYHGQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLN2</accession>
    <name>A0A317VLN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_237165</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463600.1">
        <property type="nucleotide sequence ID" value="XM_025606339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLN2"/>
    <dbReference type="STRING" id="1450535.A0A317VLN2"/>
    <dbReference type="GeneID" id="37108482"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="23"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY73848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="542" mass="60059" checksum="05E770DCDA1B54CD" modified="2018-10-10" version="1">MSDLIPSWNIVHKLEKRNLLIAINCIAGLSILFFGYDQGMMSGVNNSKNYIDLMGFGYTKMVDGELTPVVTDSLLQGGIVSVYYLGTLCGALVGGWIGDKIGRIRTIASGAVWAVLGASLQCAAQNHNWMICSRFINGIGTGILNAIVPVWATETAEHTSRGKFIAIEFTLNIFGVVVAYWLEFGLSFIDGGKSAFRWRFPIAFQIIFLLLLFASVWFFPESPRWLVKVGREQEARYILGRLRGSSGHDAVRAEAEFRDIQSVAEMERTVNYNTSYLSMLFGYKTGKLHLGRRVQLVIWLQIMQEWVGIAGVTVYAPTIFSIAGFDSMKSQWLSGLNNVFYMFATLVCVFTLDRIGRRWTLYWGAVGQGIAMFLAGGFSRLAINARDSGDAARASSFGAAAAAMIFIFTSVFGATWLTVPWIYPAEIYPLAVRARGNAWGVVGWSIGNGWLTLLCPVMFSAIGEKTLYVFAASNVITIPMVWALYPESNQRTLEDMDLLFASDSPWVWDAEKTFRQLKAENPGYVETAARKGSVVVEHVQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLS1</accession>
    <name>A0A317VLS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mitochondrial genome maintenance protein Mgr2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_538934</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463640.1">
        <property type="nucleotide sequence ID" value="XM_025612588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLS1"/>
    <dbReference type="STRING" id="1450535.A0A317VLS1"/>
    <dbReference type="GeneID" id="37114731"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY73888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="108" mass="11438" checksum="23C4B30D474D7175" modified="2018-10-10" version="1">MPVVAGPPQGHGPSTFEKMKMGALMGSTVGGIMGFIIGTVTVFQYGAGPNGVMRTLGKYMLGSGATFGLFMSIGSVIRTEGPHNDAWLRARGPPMMLPRQSPLRPMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLT2</accession>
    <name>A0A317VLT2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_578275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463650.1">
        <property type="nucleotide sequence ID" value="XM_025615207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLT2"/>
    <dbReference type="STRING" id="1450535.A0A317VLT2"/>
    <dbReference type="GeneID" id="37117350"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY73898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32582" checksum="F3073800D40F4C5A" modified="2018-10-10" version="1">MAKNTIDIYPLNRDEEESKRLNQQHRMFLNLIKNNIIDPAISKDSLRAVADIGTGTGIWLEDVGKLFTKDSIPYLHGFDISDDQFPESSEILELSVHDVLNEFPPEHINRYDLVHVRFFVTCIREDQYTQVVRNMASLIIGSFAEPGGYLQWEEGDHSKSFRAIEKEAPRLQDAVNSFRGYFVSGGFSLYAPDNIEQACNTAGLNLINKSWYSTTTASAEQVEEIRFQFLCIFQQILRISCRDRGSFDTESNAQVAVEQQIDLMKASFDKGLVPDAIFCCILYQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNQ8</accession>
    <name>A0A317VNQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_524065</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463856.1">
        <property type="nucleotide sequence ID" value="XM_025610241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNQ8"/>
    <dbReference type="STRING" id="1450535.A0A317VNQ8"/>
    <dbReference type="GeneID" id="37112384"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF18">
        <property type="entry name" value="ACID PHOSPHATASE PHO11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016412522" description="3-phytase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="71"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="413"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY75229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="479" mass="52351" checksum="F56739791DA13ECB" modified="2018-10-10" version="1">MPRSSLITLACALATGASAFSYGAAAPQSSQEKQFSQEFRDGYSILKHYGGNGPYSERVSYGIARDPPTGCEVDQVIMIHRHGARYPSPSAGKSVEESLAKVYSINTTDYKGDLAFLNDWTYYVPNECYYNAETTSGPYAGLLGAYNNGNEYRARYGHLWDGESVVPMFSSGYGRVIGTARKFGEGFFGYNYSTNAALNIISESEVQGADSLTPTCDTDNDQTTCDNLTATMPQFKVAAARLNAQNPGMNLTETDIYNLMLMASFELNARPFSNWINAFTQDEWVSFGYVEDLNYYYCAGPGDKNMAAVGAVYANASLTLLNQGPKEAGSLFFNFAHDTNITPILAALGVLIPDEDLPLDRIPFGNPYTTGNIVPQGGHLTIERLSCQATPLSDEGIYVRLVLNEAVLPFNSCQSGPGYSCPLANYTSILNKDLPDYTTTCNVSASYPQHLSFWWNYNTTTELNYRSSPIACQEGAAMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VP70</accession>
    <name>A0A317VP70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_209562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464143.1">
        <property type="nucleotide sequence ID" value="XM_025606146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VP70"/>
    <dbReference type="STRING" id="1450535.A0A317VP70"/>
    <dbReference type="GeneID" id="37108289"/>
    <dbReference type="OrthoDB" id="4216928at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY76146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="347" mass="38961" checksum="9BB67157FBF42668" modified="2018-10-10" version="1">MAPDIPRPPTLRRSCQACARGKRRCDQRWPRCTRCQTRRIDCEYVNIPLTVGSDRSSSPERTTAPTLQLTRKRPSTPSIHLPLPLEITKGYSQNIIAFLVSGMRSYPSSFASNMKTHFIHPDLWPHPSSPPSQIRDIHALCKLHTTTNSATLLPLIKQKSSSLLRQINHTTSFEEMLATAQALLLAQCMLILAEDDPATARYSESISTMLFNLGQKLWQQAPVQLPGSLSPRRAWLFAESVRRTIIVGFILRSVYSLKKRNYSVRTPFVDSLPFDVRTSLWDQDTQGWNTGVGESLDFMVSLHQYSSMMEQGMIHGISDFGGLILAACKGRAVAGLPYPPARGYKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPV0</accession>
    <name>A0A317VPV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eisosome protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_198886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464189.1">
        <property type="nucleotide sequence ID" value="XM_025606090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPV0"/>
    <dbReference type="STRING" id="1450535.A0A317VPV0"/>
    <dbReference type="GeneID" id="37108233"/>
    <dbReference type="OrthoDB" id="4070583at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024527">
        <property type="entry name" value="Eisosome1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28298:SF1">
        <property type="entry name" value="EISOSOME PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12757">
        <property type="entry name" value="Eisosome1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="88320" checksum="10F63931020D03BA" modified="2018-10-10" version="1">MATTLEQPAPIERAIGRSRSARLAGQAATAALYVTHPERRLSVREPSTAESELATLKATGSRPGFSHASAVAALAHARSRGRTTKGSATAQHVEDNRAVEVPSLEGYKAAAYVFRDRRSVASHSRTSDIKYDSSGVGQTVETRSGTTGPDRTHYAVTGALYANRKRADSAPSEAPHAGMDTDDVLGDLDSAMEASRIQHIANTNARLYTASPPVSPELEDHKRRSILQAAAVSMARDMYAVVEAKEQEQKSLSHIRSQRTATGAEPMILQQAFSLQDAAEKRAAEKLASMQDETAIYREYYGIEPQTTRSSLQVRRRRLSIDTDASSVDAERSKEIRNQMYSLRSKLDAVDERREKDRALLMEAARRNVDATIQDMEMRVYAATGRAPAAMQKGMEETALARAKQRQETDAQYQLADRVNISSEKYIDMADVEALARSRLQPTFDEITDRADIKRARELEQRLDQEEAQRREAIQREQEADTRAEEKRLRAALKSESKLKEEKAWLWSRKSKRFSDITAGERYTVTGAVDGAADEAAAETAPRQTSVGDIGATVSGATEETSPTEAISKSESKLRSWFKGRLGRRSSGIAAEAVKAGKGTQEGAVPAETGAAAQQPEETQAIEVVEAESQDSRVSQPVQRSEGEEGQTWDIAHPADKDPEVPELPAAPVAPEISGQGTVADDSRGAALGSHPVTANDLTRMSVGEGQVDERQAEDRDSQQSPDSKEESAADKRNRLVTGFKKIVSKNSQEAKTDGIGSNDIARRSSQAIPTPAVETEERRPSAPDPGLTVPAAVGKRASSGTGRESRFSEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQ99</accession>
    <name>A0A317VQ99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_559470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464122.1">
        <property type="nucleotide sequence ID" value="XM_025614071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQ99"/>
    <dbReference type="STRING" id="1450535.A0A317VQ99"/>
    <dbReference type="GeneID" id="37116214"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY76125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="258" mass="30158" checksum="128FF9C92B6CA90A" modified="2018-10-10" version="1">MMMVGSEWSLTGDHTSHIWHSDLHSVNIFVDPKTPSEILGIIDWQSTGLAPLYDHTIQPYLLDYDGPPLDLLERPDLTDIRSLYQDYPAPLGERKATSLYTKMSLVSLYRHLVHKKMPLLFKALEFRETVCFQLLLFARNLLVDGEATYLALSVDQQRKNWQDIPRFNHTDEKLPLCFSEEMLHQIEKDHEGATASIELMREIQEMIGPRYFYTDGMVTHDEYDEVSRIIPRVKEEFICKYARDEDEITELEGVWSFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSR0</accession>
    <name>A0A317VSR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_538463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464064.1">
        <property type="nucleotide sequence ID" value="XM_025612494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSR0"/>
    <dbReference type="STRING" id="1450535.A0A317VSR0"/>
    <dbReference type="GeneID" id="37114637"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY76067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="284" mass="32519" checksum="5D5D8B1091015F44" modified="2018-10-10" version="1">MATDPNPLNLDAQIHPLAHAREHVLFDLLARYLPADSPITAAQAAREINAHFPYFQPRYDPTLPHQESGQDFCFNFWELAFRLPPQLDYREEPMQRFLALRDALSELPPVILKDGDEFDGRSAWNPPFYFHMMLIERLNQIGNPEEVGDKWDIRWRNMNGFLAHLTNSGKRSYLGNALTTIRMGLEENPRKAQPKNITYNCRAPAAAIWFILCAPKIYAGCREGISSGRPSMSLWTGESGLNLPRWEFWLERLETLKGHSVTTQETKDMCQAAIEAMNRCTVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSY4</accession>
    <name>A0A317VSY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mitochondrial export translocase Oxa2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_202073</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464234.1">
        <property type="nucleotide sequence ID" value="XM_025606106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSY4"/>
    <dbReference type="STRING" id="1450535.A0A317VSY4"/>
    <dbReference type="GeneID" id="37108249"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY76421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="328" mass="37171" checksum="9CBE63259F2371EB" modified="2018-10-10" version="1">MRAFRLSHPARKTAAFQHVRHFHPTRPAPLINEALQLSSTYLHAVHDISHLPWALSIPLSALLVRTSVAMPLQIYTKVQALRERDAIPLTLAWHHHIKSRIFSDRDRTPPSPAQRQAVMREFLVKKRSVHRGLKIPRFWKPMNFVQLPIWISIMESLRAMSGNTGGLVPWLLSLIRPESADPATTLAIEPSLATEGALWFPDLLAGDPTGMLPLALSLSILLNVHLGWKTKPLKNMADLPKLEMYKQVTFRGLRIFVQVLALNVGLSSFVSEMPTALMIYWVTSTNIATMQTFILDRILVPAKPLPAWQQKYMMYKMPGKETLPPTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTM1</accession>
    <name>A0A317VTM1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_198529</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464180.1">
        <property type="nucleotide sequence ID" value="XM_025606087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTM1"/>
    <dbReference type="STRING" id="1450535.A0A317VTM1"/>
    <dbReference type="GeneID" id="37108230"/>
    <dbReference type="OrthoDB" id="1612078at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000318">
        <property type="entry name" value="Nase_comp1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021102">
        <property type="entry name" value="PNGase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056948">
        <property type="entry name" value="PNGaseA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31104">
        <property type="entry name" value="PEPTIDE-N4-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25156">
        <property type="entry name" value="PNGase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12222">
        <property type="entry name" value="PNGaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00699">
        <property type="entry name" value="NITROGENASE_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016419721" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY76367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="555" mass="60998" checksum="7500CA26834EA0D9" modified="2018-10-10" version="1">MLASLYAAFCLGSLLFSPARALLEVFEVYQPVSITHGSAGCNTEVLLMDHVFGYSYGEPYVGIYEPPNCTFDTVRINFTVTSKGTQYDRLALMYLGDTEVFRTSTAEPSTNGIIWTYIKDMSQFNVLWKEKQKLIFDLGNIITDVYTGSYNATLTAYFSYEGNVKTPDVILPISARKSGQNASSDFELPTDNATVLYQFPPTTSRAVVSISACGQSTEEFWWSNVLSADEYSFDNTIGELYGFSPFREIQLYIDGILAGVDWPFPIIFTGGVAPGFWRPIVGIDAFDLRQPEIDISPFLPLLTDNRSHSFEIRVTGLNVSDDGTVTFSNTVGSYWVVTGTIFLYLDDSVSQSVTNSTNGQAPEVIAPAPTFEVTRNLAQSRNGTNETLSYSVLAERTLTVQSSEYSWSQNLSYSNYGSLNQQGLSQKNNQQTFGQNSISQLTGTKTTDEITFEYPLICNTTYGLEDGLSISALIRRGLDIESTGGLGVSTYTFTSGALNLHTEQWGTAYYYESSDDEGSVSTGETTDVFQSNAGGVPYYRSVRAVNGTVVSDTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWM0</accession>
    <name>A0A317VWM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_189134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464687.1">
        <property type="nucleotide sequence ID" value="XM_025606031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWM0"/>
    <dbReference type="STRING" id="1450535.A0A317VWM0"/>
    <dbReference type="GeneID" id="37108174"/>
    <dbReference type="OrthoDB" id="5386674at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="841" mass="92557" checksum="1BF84D7020B796EE" modified="2018-10-10" version="1">MDNDNAYESAAGHSKFINMDRSGQSRKPRRSSFSQHLQRVFHWDKHVTQEKSSRISDPLETAFTRSHRQEQRALPHTDEFIRDNISKSTSSIGTNEDAVSQTPQNSRLSVLNRDGLKKLPAYSVSQGASQISDHSFVGNAFYKQELSGSPSRINKAVHKNERRATRRLEAERLELEKRLLKLEQTGPDQGNGLQKKETRRLTKKQPIRSSSRASSVSADECSSTRLSSLFSSSQRTSRSRSSSLNESDKEPPRHPLIDVREAVSGPDLGIQSIRPHVTLTMPERLGAMISRELATSNALLPHRHNGVATEANTHGIESRTDEAGDHQYHYEKSLSHGLAPLQSHRANIERNIPRVASTAPSPSAPPADLDRLSFAATLNLGTRGFEAVHHSSTITFPNLATKQGNQNHRNSKSIWKTHIESDIGPHAAISPVQPSAALQGELSKTPSNKSPTDRYLQRPHKKYIPSPLAESSSLDGNSSLSLNSKKATTMLKLQASGNAEQTPSSVSTKKDEHPRYDRSHPRPTTRLLTTDVRQCEGVDDPVISIIRGPQEKSPDRGSYPWVYGTKRSSSVGLSGHGVKYIGQSESVGFQDPRLHDKTLAFQENLSRGSQNVPQSERLEACHVSSKSKISQPSVSNSSLATSSEEPQSEDYDTADEARSPVLLAQDHNVHLVRCPDHGTIPTGVNVADGDMLFSLRTSTAAVPDRPEARTDGRMVNMRNLQANSSIGMRFVICCHCSHWHDIPSDVYAKLSPPDTPSVVRARRLSSTQASKSTLTKHTISNLAKGKLFGAPSNLSDSGPSASTTKTKASMSTVQCCWCSHDMNRSCCQGWTAIVHMCRRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYT5</accession>
    <name>A0A317VYT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_577278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464800.1">
        <property type="nucleotide sequence ID" value="XM_025615171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYT5"/>
    <dbReference type="STRING" id="1450535.A0A317VYT5"/>
    <dbReference type="GeneID" id="37117314"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7580" evidence="2">
        <location>
            <begin position="660"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="910" mass="101766" checksum="B164D614126CD310" modified="2018-10-10" version="1">MAMAVLLPPKDRRDFDVAIICALQLEADAAEALFDHFWDDAGDQYGKAPGDQNTYRTGVIGNHNVVLAYMPGIGKGYAASVAASFRSSFQGIRLALLVGICGGVPGGTEKGIFLGDIVISDEIVIYDLGRRLPGGFYRKEALTNSPVNLEIRAFLHKLKGQKGREHLLNQTHRHLTTLQDRTGDYRCPARRLDRLFKPTYHHKHHNAARCWKCKKNELCKQAQETLCEELKCDTRRLVVRSRPSPNGIDIHFGRIASGDTVMKSGVDRDKIAAEENVIAFEMEGAGICNNLPCIVVKGVCDYADSHNDKVWQKYTAGTAAASIDRNERRDEQPTDTLRTGSCCHLDTTLSQAASSQSTYQDEGYNSQKNYDIGDGDLSRVLPTIDRNFKAALTGFRKHRKYLPRDVDLKSTLKTQRVIFSSNVEIMPSSGPLNHSPDLSSKVLLEVTIAIRTKLEEIEDATRRLPVATKAKVQPRSVADTLKDTVEDLISLVQVFTSLTPQPKQSRLSKESKVARNPGCRREFQHFRIVQQVACNLYDVLGTACNAHTVHDVHISLRPDLDGTLTRARFNVAFVRNPMAPGEAVWIDVESTIKTFEPSPQTVLTSVSRGPSSLKRPRQLQEAQACSKRVQFQLLPTLLSEPLQSRCPEEPITGIPNLYLQRNFCTVVERSLQQRECNDCIGLLGGNQIYQHLAYMGNQTNQTTMSMSLSKLITLSGADPTKGMGLYECVRLARYLATAVLYYHATPWLRKAWRSDDVQFFGAPDSLLQQPQNILPYMSTSIRASNSSMQSQSQPSEYQHIIRNPVLFGLGVMLLELAYQAPLRNLQQPVDLMKGETPGFADYFTAHRLVDYSCRKVSKSFRMIIKKCLHCDFGHDSDFTSPALQEAFFHDVIGGLENLEKVFQELQPDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZE4</accession>
    <name>A0A317VZE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_175179</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464701.1">
        <property type="nucleotide sequence ID" value="XM_025605939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZE4"/>
    <dbReference type="STRING" id="1450535.A0A317VZE4"/>
    <dbReference type="GeneID" id="37108082"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="401"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="15">
        <location>
            <begin position="465"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY78392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="741" mass="84592" checksum="7B372FE2BA09B43F" modified="2018-10-10" version="1">MAAINMASSSGVNFASEVRRRTVPRTGKLSHAPDHEVYDDEKSKPEPASFISAVAHWEPIIAPLLLTAFAIFTRMYNIGRSNIVTWDEAHFGKFGSHYLKREFYFDVHPPLGKMLVGLSGFLAGYNGSFEFKSGEQYPEDVNYTFMRIFNAAFGAACVPLAYYTARELGFRKATVWLISLMVLFENSYATISRFILLDSMLLCFTFTTTLCWARFHRLQSASFSTEWFAWLFLTGVSIGCVCSVKWVGFFCTAIVGLYTVEDLWNKFGDLKMPEVVVAKHFVARVVGLIIVPCVVYILSFYIHFWILENSGPGDAQMSSLFQANLKGTEVGKDSPLEIALGSRVTLKNMGYGGGLLHSHIQTYPEGSTQQQVTCYHHKDANNDWFIYPNRYEPEFDPEGPLRFIGDGDIIRLIHGQTGRNLHSHAISAPVTKSQFEVSCYGNITIGDDKDHWTVEVVDDVASRDRTKIRTLTTAFRLRHPALGCYLRAGNVNLPQWGFKQIETTCVKENKPSDVYTHWNVESHYNEKLPPGDPGSYKSPFWKDFIHLNVAMMTSNNALVPDPDKQDDLASKFWQWPILNVGLRMCSWDDNTIKYYLLGNPIVYWGSTLSLATFGLLVLWYIVRWQRGYNELTQADISHIHYSGLYPVIGWVLHYLPFAVMARVTYVHHYYPALYYAILTFGFCIDWFTQGMNKKLRWVVYASLYCIIIGMFVYFRAIVFGIEGSSQQWSHLNWLNGWRIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZP3</accession>
    <name>A0A317VZP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_537668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464791.1">
        <property type="nucleotide sequence ID" value="XM_025612321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZP3"/>
    <dbReference type="STRING" id="1450535.A0A317VZP3"/>
    <dbReference type="GeneID" id="37114464"/>
    <dbReference type="OrthoDB" id="2896006at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="325" mass="35905" checksum="9729789AD2C7BF38" modified="2018-10-10" version="1">MAEPPLHFFSILYRELSYAFIHSTGHDPLIARANRFIQTPAPNRNAHRLIPIGLGILAKVLIRYIISHVVLSILILETAEQQTNTSKPGDNKSSPSSRQLLRTTAVFYHKGGLRLLLNGIGSACTYWLMHTSVTKISTTLLPHPIAHILTSVLLAESHFFWTARTILPPDQLRLVPNPHDYQRWKALIPATLVYATSEIVMMLVSGLFDVPLPVTTTGLSWFVGSDVLRYGLVLAVQMFLIFPAYILLIMVQGSLLPPTCETLVFAQLQRGRRVGEIFSGEGGVGDVVKMLGVKQLLWCLELHGKMGLCLVGVAAVVHSVVYSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZR5</accession>
    <name>A0A317VZR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_537646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464766.1">
        <property type="nucleotide sequence ID" value="XM_025612315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZR5"/>
    <dbReference type="STRING" id="1450535.A0A317VZR5"/>
    <dbReference type="GeneID" id="37114458"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="408" mass="43718" checksum="BB95C6B9220DFCAB" modified="2018-10-10" version="1" fragment="single">MLVSSPSPSAALRPSPSSPTTTTTTSHSLAHSHHSHSHPNSHPQPPLPPSSSTSSSSPFATHSRHPPPQHYEPPGPASAAAASNPRFEPQSSRLAIEELRSALNRHTVGSSPPGPSGDFSRGRMSAGLTSGGGSSTTSHPPADAAIPASNPTHPSLDRPTNNVSAAAVPASSSVPAPGAHSTFTSSMPAPNSAGSGSNKRNSPNDLPAGDARVAGLGHADLEGSQTKRMRPEKPEVKLLPQRYELADSRDIVVLISSMLMELIRFNDKIPLNQGRLTRFHSRSPPRISVQDYLQRLTTHATLSPPILLSMVYYIDRLCTLYPAFTVSSLTIHRFLIASATVASKGLSDSFWTNKTYARVGGITMTELALLELEFLFRVEWRIVPEPEVLVDYYKSLAERCDGYAIERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W0Y8</accession>
    <name>A0A317W0Y8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_155955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465165.1">
        <property type="nucleotide sequence ID" value="XM_025605841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W0Y8"/>
    <dbReference type="GeneID" id="37107984"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18912" checksum="38F1373A0B107988" modified="2018-10-10" version="1">MVVRFKIWQRLRKCLSNTQGEIRAVVLLKKLCPEENSKSKLSRQSVLEWWTRLVRCLPQQSEQYSHTRNPLAESDSATYFLLSGCLDSFPDATWDRAQLYTAGLLNSIGDSTCLDGLCGIMRQQQQQLKSIHNMHSGAQHGDKCRISRRKEKMASNAATLVWSPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1D3</accession>
    <name>A0A317W1D3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cytochrome c oxidase polypeptide VIa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_471578</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464983.1">
        <property type="nucleotide sequence ID" value="XM_025608386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1D3"/>
    <dbReference type="STRING" id="1450535.A0A317W1D3"/>
    <dbReference type="GeneID" id="37110529"/>
    <dbReference type="OrthoDB" id="5947505at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.95.10:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6A, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018507">
        <property type="entry name" value="Cyt_c_oxidase_su6a_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01329">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY79411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16558" checksum="1E9D94E1078B8885" modified="2018-10-10" version="1">MFPQRNALRLSQRAAQQLRAAPVRSTVQRRANSSDSKQLPSWAVDNEFNREREAVKHHAAATSDLWRKLSIYAVIPVLIAGGINSYNLWNEHWEHWAHMPALEDRTEYPYQNIRVKNFPWGDGDKTIFWNSSVNYHNKDKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4T2</accession>
    <name>A0A317W4T2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_537188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465171.1">
        <property type="nucleotide sequence ID" value="XM_025612211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4T2"/>
    <dbReference type="STRING" id="1450535.A0A317W4T2"/>
    <dbReference type="GeneID" id="37114354"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="4"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY80312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="361" mass="40730" checksum="DF782D88F3C4ECDE" modified="2018-10-10" version="1">MPLTHLPPEVLLIIASYLRHQRDVYALVCTNRQFYHILRDFLYQYNSRYFHASALPFAAKHGNEYMVRKLLDGLKSAVGKSRKLPCSQRRKQAIQDKVVLDSGSESDTVWSDVSVKSEDIEIPFVTDIITHPLRAAKYTTTDINTIQSALIAAIQTGHKNIVKLLLDWGAQANFYRGLRRVNHYPEPRRCTKVICVDYPPLCQAVQCGRAALVKLLLERGADPDRYCYSPLYQAVASSRRDIIQMLLQHGAKFHSRSLKLAVQRADMSMVQFLLENGVRADESGHSALLVAKRKSMEDMVEFLQSKGATLDVEFGPSDDSENDDYDERLDTYLPDWRSPSLPAVGAGVEDFDDVSDGVGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W956</accession>
    <name>A0A317W956_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_495339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465931.1">
        <property type="nucleotide sequence ID" value="XM_025609259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W956"/>
    <dbReference type="STRING" id="1450535.A0A317W956"/>
    <dbReference type="GeneID" id="37111402"/>
    <dbReference type="OrthoDB" id="3438840at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="775"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="868" mass="94739" checksum="BA792F3FF1168B67" modified="2018-10-10" version="1">MLATASATEDAGHSHRPPPPPLPPSPTLSNPDMILPFDRNERDSSTPSPPFNLPPLSSLQSFYENRTASDDVGDQARGIALSYGTRPQKIGFSRRTWLTESQDASRRLSDIGEEDSISSSPAHSRTLQFMSQAGRMTGSPVSQRETADAEAREMAAWSSSSSSTISGASDLSQDATKGRQESRGVAQNPYQVTEGVRSAIENLEGNGSTSSLMATTEEGGSGVELSSAVLSTEAERILENAKKRLTLMEGNLSRARTSMRSSPSLSASPTPSVGHQTLGLGQPVGGLYQSISRADRRGPNQRPRATYTSSQDAINNGHSRVYSETQLPSTAQSSLPAVEPDLSRSVSALGSTTAPSLNHDERSFRYDPTRAYLTHRASVSSMQRPQTRASPPALNKRAASESPKGLGISREEHENEYYGVNGHGAAYPTYDPPSRSQSQLQVRDLQDQMKGLHIKISSLKVKAQEDNLRRRSLQSLRTPSPLAAADLTTADQWFPSAVDLKERRSNTNISAGNGRAAGYTQDNRYSGDYGGARYESEAGAGRYTKREPAYQPASHADPAHRAYESRDHDDGQSEAGTLYEDAEEGEYELDSPSNPEFDRQALNEMLREPVDEEFDDSLESFPAVPQSLEDTPHEEREDAFDYENFILHSALGNYTQARLRRESNVSTSSVETTRPIDHHAARHSRANSTTSLSTVATFATATEGDRDDLESVLYWDRKFNDELRNNHPSDVDMRESNGTDPDAQGTPRAMRRQPSRRNQGSLFPDAGLAPRRSDSATTGSTTPTSLVSSLVSTVRAASSPHPSATAKGNMGLNDDDTRLLEQLFQSLGNVCLDLQNITTSENPDFKEVRLLRRRLDAARRVLDGELDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WA43</accession>
    <name>A0A317WA43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_519956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466028.1">
        <property type="nucleotide sequence ID" value="XM_025610089.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WA43"/>
    <dbReference type="GeneID" id="37112232"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF26">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="3">
        <location>
            <begin position="248"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="6">
        <location>
            <begin position="554"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="4">
        <location>
            <begin position="747"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1272"/>
            <end position="1292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1318" mass="142892" checksum="4E393F4953453249" modified="2018-10-10" version="1">MSSSKLNIKIAIDRGGTFTDCLGIVEGREDDIVVKLLSQDPSNYSDAPIEGIRRILEQATGKSFPRDQKLTTSDFGSVSIRMGTTVATNALLERKGERVALLITKGFKDALRIGTQSRPKLFALNIQRPDVLYEDVVEVDERVTIEGYQQNPLQDIEGLEAALQTDPCLKRGVSGEVVRILESLDEIKTRQSLQALYDEGYRSIAVCLVHSYTFQEHELAIERIASEIGFTQISLSSQLLPMIKMTSRGASATADAYLTPVIQRYIQGFRSGFQDELRSTDTRCEFMQSDGGLVNFQKFTGLRAILSGPAGGVVGYAGTSFDPENRTPVIGFDMGGTSTDVSRYDGKLEHTFENTISGVTVMAPQLDINTVAAGGGSILFWRHGLFVVGPESAGAHPGPACYRKGGPLTVTDANLFLGRLLPGYFPKIFGPNEDEPLDIEVTRRKFTELADQINAETGHQKTPEEIALGFIQVANESMAKPIRALTEARGYDTSAHNLACFGGAGGQHACAIASSLSIKTVIIHRYSSILSAYGMALADVVHESQEPASGVLTETAMESIQDRITALKAKVTEALTTDGIEEARIQYEIYLNLRYQGTDNTLMVLRPENGDFEAAFIQEHQREFSFTFPGRNILVEDIRVRGVGKAISVPPEAPQPELRSLMSSVVSTEKQDDSTEVHFAGVGRVATPVFFLDHLEPGSFIQGPAMIIDKTQTIVVEPNATATILSRHVILNVQSVKKQHDDATVVDPIKLSIFGHRFMSVADQMSRMFQKTSVSTNIKERLDFSCAVFSPDGKLVANAPNVPVHLGSMEYAVRYQHEQYGSDLKPGDHILTNHPLAGGTHLPDITIITPVWDQHGSKIIFYVASRGHHAEIGGIAPGSMPSDSKMLYEEGAMTMGFKVVSEGRFDEDMVRKFLYDEPASYPGCSGTRTYKDNVSDLKAAIAANHKGAQLLESLVRENTLEVVHFYMDAIKKNAETAVRQLLKTIGKKAAGQPLRFSDFMDDGTEIRLEIRIDAETGSAEFDFTGTGRETFNCLNAPKAIAHSAIIYSLRALIDVDIPLNQGCLAPINVIIPSGTLINPSGYAAVCAGNPITSQRITDVVLGAFQACAASQGCCNIISFGMGGLDENGNDIPGFGVGETICGGSGAGSTWHGTSGVHVHMTNTRITDAEVYELRYPVILRQFSIRKGSGGKGLYRGGDGVIRELEFRIPLSASMLSERRVYRPYGLAGGEAGQAGLNLYVKKELDGTERVINIGGKMELKVQPGERIIIHTPGGGGWGAPSEEDSIPISSGNNPELNRVGFEPRGSVHNFSATAEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCD2</accession>
    <name>A0A317WCD2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_116293</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466357.1">
        <property type="nucleotide sequence ID" value="XM_025605542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WCD2"/>
    <dbReference type="STRING" id="1450535.A0A317WCD2"/>
    <dbReference type="GeneID" id="37107685"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05198">
        <property type="entry name" value="formate_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="4">
        <location>
            <begin position="163"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="339" mass="37118" checksum="36B0375B43A3B5E0" modified="2018-10-10" version="1">MLQHESHHIVAIEAVHCPIPTFNLPCPYTVDTYHWTSQSELAHRIKDATIILTTTIPLSAEVLSPDITPNLQLIVIMASGTDCVDRVACQARGITICNCPGTNMDSVSEHVIGAYFATRRKFVHLHQATVSVPDDPGVETEWKMNGTLHPRLRMSDGNPPLLCSQETLGILGFGALGRRVETLAWALGMKVIVSDHKGVVPRDGRVSFETFLKESTVLVLCLPRSSKTVNLISTEEFRMMMPQAVVINVARGGIVDEQALLDAVKEGVISGAAMDVFKDEPVGRGGSPLITREIEEEGLNLLLTPHLAWYSGMTLRNLQEGVKGTVERWVGGETINRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE64</accession>
    <name>A0A317WE64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor Btf3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_557948</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466093.1">
        <property type="nucleotide sequence ID" value="XM_025613964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE64"/>
    <dbReference type="STRING" id="1450535.A0A317WE64"/>
    <dbReference type="GeneID" id="37116107"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="136"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="365"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="447"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="722" mass="80416" checksum="743151E725A7ADDF" modified="2018-10-10" version="1">MALPENAPAAVTNGQPPDLHAQVDVICGPLINFKNMDVNPSSSIWRGSVLIVIQPGQSQPRLLLRQAGPVGGNGAGNGAHSNDAAVAVDGVRLYEDPQKAFWRFSLALPLESYEARWEYFIPGFRYAEGNEVYSPWDFTVSSVNQSMRLMFHSCNGFSVGTDMNAWVGPNLWNDVLRVHAQKPFHAMIGGGDQLYNDGIRVDGPLKEWTSISNPHTRRAHDFDNDLRARCDEYYYANYIRWYSTEPFKAANGRIPQINIWDDHDIIDGFGSYTDHFMRCSVFRGIGGVAFKYYCLFQHHIAPPKSTFTTDAPQTMHAVNGTAGADPRQLENTFVLDEQQEDDSWIVGKRPGPYVEEKSRNLYMRLGKRMAFIGVDARTERTRHQVNYPDTYDLIFSRLESEVAAANGDIKHLIVLLGVPIAYPRLAWLENILSSPIIAPIRLLNKRFGFAGGLFNQFDGQVDLLDDLDDHYTARQHKKERRIFIQRLQDFSKIHSVRVTILGGDVHLAAIGRFYSNPSLRIPSEHDPRYMVNVISSAITNKPPPKAVANLLARRNKLHHMDSSTDETLMDFFDRQPGGQEKSASWNKVTMPSRNYACITEIDTPVSNGNASATQGDIAAFPIPMDGHSPLHKGEANAGSSHPAADGFSSSSDMPGGLDVTIRVEINPQDREAATDGYAFSIPALAYVPSEADSRPNSRSRSLRPRSLRPPSRQSARPHSAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WG35</accession>
    <name>A0A317WG35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_494502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466586.1">
        <property type="nucleotide sequence ID" value="XM_025609233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WG35"/>
    <dbReference type="STRING" id="1450535.A0A317WG35"/>
    <dbReference type="GeneID" id="37111376"/>
    <dbReference type="OrthoDB" id="10264848at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF97">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="2">
        <location>
            <begin position="231"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="644"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY84661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="734" mass="79372" checksum="CF9C37933F1DD811" modified="2018-10-10" version="1">MSANASDNGAGKPRLHTARSFPRMDSPDTSPFVRSRAKTVQSVAIPELVDAEALPLPLSTPDEERIGSPDLFEKPGSSDLGDDGQQGEEISVLSRGSQGHTEELPIELASMTDRFVHSLTAKVHSSPPTIEKVSSRFQEFYVRAESHIATHISALASRINRDPSPFRATQGKSSNKGSDGRQMLTASEVTEKRIARKHLASKRVALEEAVERRACETIYDKLWRHNSTLDEIRDEKLRSKTAALSLVGINLKDLGVDLDLGAINEEKQKEADECLAAARDCLAKMNDDKYPLGKLQQLAAAHKAIVDALTKLLPSSSSADEILPTLIYSLVTCPPEGINIISNLFFIQRFRSSSKIDGETAYCLTNLEAAISFLENVDLTELRGEEAFEGQTKAANDDSTSAGKTDSLQSHNASKEAAVSSVTPVTASPELSNPVGQDALGTLPRPQSSASTQQRRLNNLFQPPAKVLGAANDAVRNTADQGLKNIGASLDSSFNFLFGRLKELQSNQFPVKDGNNPVLPKTLADARRLVTNPISTGNNLGQDENSAREPRSTDRPPLRRIGSKAEDTFLGLVSGQRTPRDRSVDSVRTQGSSRKTTVSQGPQKEEPQVSPASTASLATTPLESMRSFGNTLNPLNHIPGMIRNFGRGTPGTPDTPGPMPSPNTPTERIRASILSRESSSSNVPSAPPRVERVEPPIQRFLQMQNVSELTIGDVSVLLEDYKRIAAALSKQSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WI73</accession>
    <name>A0A317WI73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_599442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466378.1">
        <property type="nucleotide sequence ID" value="XM_025616324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WI73"/>
    <dbReference type="STRING" id="1450535.A0A317WI73"/>
    <dbReference type="GeneID" id="37118467"/>
    <dbReference type="OrthoDB" id="4330117at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="426" mass="47104" checksum="06CC0B59D8AAE264" modified="2018-10-10" version="1">MSSPLDLSLRRSCDRCHEQKVRCIRDLTLSEEGTTSCVRCRKAGAICLYSPQLRAGRPPACKRSRPSTTVPDSDLPAPSTHPDEEPFSPSLFFSGLDSELAFEEDPIPLLAPVQALPREHVTEDPTTTPTPTTTTSSIDPVDNELMELGELARRIHRSAHVFTAPNLSGIHPLSVSSPAIQELCDAAFALIRRIPNLPSCLATSRTPFWAPTAGLPPLWDDGQCSWSAWSHHFNDIPFWRSPSSLDAGLVLMVLACHQRLMAAFENVTLSVSHHLLGPTPINSITHTHSSPLLPHHIPPHPRHSPDSFTTETYRGRIIPPPQSTQALLIVELLDHLLDQLDGAFRPLLPDEQAGKSIPEPSSTTNRSTLPSPRCSVLQKDPLMADAEVSLCVETARSMIDAMQHRHGRLRGQLKEIRRRIKDTKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ80</accession>
    <name>A0A317WJ80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_85381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467105.1">
        <property type="nucleotide sequence ID" value="XM_025617708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ80"/>
    <dbReference type="STRING" id="1450535.A0A317WJ80"/>
    <dbReference type="GeneID" id="37119851"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY86514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16841" checksum="FA1616A386C3D56D" modified="2018-10-10" version="1">MEPLPSSDQPQQPPPPTLTNPRFTLELEFVSSLANPYYLSHLAVTYPNLLGINKSGDDSDVNNESVDPDAKTFAAYLAYLYSYWKTPEYAQFLTHPGATLRALRLLQEETFRRDIIRPDVIEMLAGTGIISDQGDTSAETEEQEGEQAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJA4</accession>
    <name>A0A317WJA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_80988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467000.1">
        <property type="nucleotide sequence ID" value="XM_025617687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJA4"/>
    <dbReference type="STRING" id="1450535.A0A317WJA4"/>
    <dbReference type="GeneID" id="37119830"/>
    <dbReference type="OrthoDB" id="5405781at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF128">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="32"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY86409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="473" mass="54173" checksum="3229B9F60A7BB585" modified="2018-10-10" version="1">MRFLHNSRLYTTVQDTFWGASSSQGDARRSVKWIDGLRGIASFLVILTHLARAWDYGLFSPRDTEVVPARVLQWPILRIPWQGRIGVTIFAFLTGYVCSLKPLKLSRAGNHLDSFTAVAKSAFRRPLRLILPATIALIISWIMAQFGAFNVANRSDCQWCRYAAPDVEESLSSEVIRLGRNFLSTWTNGYMAYDDHQWALLPLLKASMLVYVLVCATMFVRFRWRVVIYSLLILYFHQDASKDTETFQIQAIYGLFLADLSQSSVLPTLIHAHPWLRRFFILTLLVPVGLYLASYPGENPTWSPWSAQLFELATYIFPPEVNIAKRYTAIGVDLLIAAIFLSPTAQRVLSSRALLWLGRQSFAVYLLHGTLLRTVLCWMLYGTFSGEPWLETIDEETGAVTSPPWLPFKGGWRWGWIIVWIGLVYGVAMLWTRYVDPWCARITAWIEKKVSHNDEKDGQEDIEVGRMRRMAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJP6</accession>
    <name>A0A317WJP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_467786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466898.1">
        <property type="nucleotide sequence ID" value="XM_025608223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJP6"/>
    <dbReference type="STRING" id="1450535.A0A317WJP6"/>
    <dbReference type="GeneID" id="37110366"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY85881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="339" mass="39210" checksum="52E982DE416E015B" modified="2018-10-10" version="1">MSSKSLFCLGQCLRGKASTYRITRQVSEFVYFAADQHDNRVVVKSVEGHWRLHNERDILSRFQSRCPNLRPLLDEIQDPVEPPAIILKYLDDDVTRASRKQRLTRQEIKYVAKNVLEALQVLHEDGYVHTDIKPSNILVNYGQGERRFSDVQLADCGGGVVPSDSEYAVDGVPTGTSLFRAPEVHLEIPWGPAADIWSFGLILQQLINLIWGFNFHLFEPDVPEGHKLYDVKIVVLHHQWFGPFPISYKEIADEETQETIMRIMSVIPPEKLKPFRFIGKREICDADKAFVLKIMKLDPRDRPTAKELLQDEWFTERSERTVGWYSKQEWEQMNKLGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJS6</accession>
    <name>A0A317WJS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Splicing factor 3b, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_575421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466906.1">
        <property type="nucleotide sequence ID" value="XM_025615075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJS6"/>
    <dbReference type="STRING" id="1450535.A0A317WJS6"/>
    <dbReference type="GeneID" id="37117218"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="259"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY86315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="547" mass="61811" checksum="AB2C0CCC996A3FED" modified="2018-10-10" version="1">MGKNQLRRARKKALKSQVVEPTSDNPPAETQVDETITSSVPKAATIDLQHAVSPDPNDPLWRIYKDIVEKFDETEDGQTASKETLKPVIYFDDDNDIPDEEEKEPSLSKRKRKELNKLSVAELKAMVRRPEIVEWTDTSAPDPRLLVHLKAHRNVVPVPSHWSLKREYLSSKRGIEKAPFALPRFIQETGISEMRDAALEKQEQATLKQKQRERVQPKMGRLDIDYQKLYEAFFRFQTKPELTRYGEVYYEGKEYETNLRHLRPGELSAELKEALNMPPGAPPPWLINQQRYGPPPSYPALKIPGLNAPPPPGAMWGYHPGGYGKPPVDEHNRPLYGGDIFGVLQSQQAVQQGEPVEKDLWGELQAPDMSEEESDADEDGDSADGEEDDIEAGVQTPSGLETPSGLTSAVPSEVTGHENIAGEFDVRKHYRGTQTEESVGQRSAFQVIPERQTQVQGFFGADRAYDLSVSSNALPVLGSDEHSKKRKRPGDIDVSVDPDALHANDGFDREDIKKLYESQRQQHTHPNWDFQEDLSDMIARESRKRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJZ3</accession>
    <name>A0A317WJZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466976.1">
        <property type="nucleotide sequence ID" value="XM_025611809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJZ3"/>
    <dbReference type="GeneID" id="37113952"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="52" mass="5796" checksum="61516FBFA480FF94" modified="2018-10-10" version="1">MYVRTQSTPPYLQRTEYKSGSGVLILISHFGLVVLVECPIVGVKLFRDGPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKZ2</accession>
    <name>A0A317WKZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">STE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_94608</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466744.1">
        <property type="nucleotide sequence ID" value="XM_025617753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKZ2"/>
    <dbReference type="STRING" id="1450535.A0A317WKZ2"/>
    <dbReference type="GeneID" id="37119896"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000390">
        <property type="entry name" value="Transcription factor stea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="569"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="599"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="447"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="496"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="619"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="499"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY85727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="699" mass="77380" checksum="EF1B2B667DBB9728" modified="2018-10-10" version="1">MYSQHGAPMAPPQKPETFMLSSEAQQSLPHDAQVALQQVDNLKYFLLSAPVDWHADQLIRRFLLPTGDYISCVLWNNLFHISGTDIVRCLAFRFQAFGRPVKNSKKFEEGIFSDLRNLKAGTDATLEEPKSPFLDFLYKNNCIRTQKKQKVFYWYSVPHDRLFLDALERDLKREKMGQEATTVAVSEPALSFEFDSSQSLYEQLTKAQQANSSSFAAHASTTYGQPASPVVRTVDAMPPPQMAPQMAPPALPLLPDESGNPAMYNPVHMPTTLAQSVIKREAEYGHIQYDRNGMPIARIHQRHASMPTFVEYSPAPSFVSSQYEDYSNRGLSFEPVTPPQHSAHLGAEPAYIANEDTGLYTAIPDISSATTFNPMMQLPPSNLATAHYPAPARTFPSNVYSVIEGSPTYKQRRRRSSIPPSITSIGATHAQVTSAPNQAVAYAAHKPSDLRRSVSSSVAPVAEVDESHHDPSYRSANAYRAAVLPQKNLLHEMSRNSTPLPSLEENPEPSSLALANQPDELAPLPSGEALDASVQNSVTNKTERFVPGPLRRARSATMMELGPYPQKSHSCPIPSCGRLFKRLEHLKRHVRTHTQERPYPCPYCNKAFSRSDNLAQHRRIHEAQQDGQQPLSGHEDDLENEENGFVSPDEGSSPSESISGTVINVPGMTSMPSAMTLPSAMPTMVAPHMIAPQLLQQHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKZ9</accession>
    <name>A0A317WKZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_556661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467372.1">
        <property type="nucleotide sequence ID" value="XM_025613881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKZ9"/>
    <dbReference type="STRING" id="1450535.A0A317WKZ9"/>
    <dbReference type="GeneID" id="37116024"/>
    <dbReference type="OrthoDB" id="4442598at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="640" mass="70611" checksum="429E5DAAAF28B427" modified="2018-10-10" version="1">MSLYSRFQPLAWRRACLPFGISPSQCRHVSVNNWRASYTEPTPSQLLRFALMGTTKPSGNDVSNPELDQHLSDIFLGDWPLGSLPPPFWSSSQRLTESPDDFVSFKGLKHDVRNLRHLQVFVERNVSEEEGSLLLQAQSCTLLAQALKRCQRHNSYGEILSALNAIITRLEKLGLPCSGNLYFLGMYYAALTWSAPALERFIEGYHSVSSSPLDSQSSTSLVDALLDALHSLRFRGKAEDTSAILDLITGRWRSERDLHSLLCWVSPDDPTASSGQYLSLLARLGSEKLLTEAWSQTLQRLSSGSSFELFQSVYSCVVALVDIGDIPKAIQYLAAVSKHAKDTLPGISRFNGLNALLASEAISALLPQLAGRREYLKLLEVQLVDMEGRLGLCWEPGESYHRSASDPLLLASEQPLLTLDGDSTGYESTERFLAEMRALGCSRSARDLGQIAELLDEHEGDVIPVSVPSIKDSKFEFAWFPRLAPVPSTRVVSSATEDTTSHWIPSTLGLIRVSYDNNGVPLTSERSIHAMQLGLLVRRHKCTNDSRPDYAHPWEETGHMVAWDRVYGQLIAVFSGQSNGPIEHRIETRAARPRSGLSAITTIGLPGDTSSTSNTDLIHSIGNGSMHYHIDADPGPDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLB1</accession>
    <name>A0A317WLB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_566568</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466864.1">
        <property type="nucleotide sequence ID" value="XM_025614565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLB1"/>
    <dbReference type="STRING" id="1450535.A0A317WLB1"/>
    <dbReference type="GeneID" id="37116708"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="139"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY85847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="360" mass="39907" checksum="0EAB14D97C009D8A" modified="2018-10-10" version="1">MASKTWNVGIVGYGLSAKTFHIPFIQEVSQFKIYAVVQRTPKPDDDAEKDHPGIKSYRSAEEMIKDEGVDVVVITTAPDSHYDLVKLALENGKHVVCEKPFTPTSQEADELVALASKQNKLLAVYQNRRWDADFVTLSKLVKNGSLGRVVEFESHIDRHRPEEPAADASKWKNKVIPGGSSIYDLGSHLLDQAVYLLGKPERVTAFIGSQREVNTSGFEDSFTVLLHYPKGVLATVKAGVVSPDSEQLRFWVRGDKGSFKKYHFDIQEEQLRAGAKPGDSGFGREPSERYGTLTTVQDGKFVKEVAPTVEPPTWTEYYRKLARALAGEGDLPASGAEAREIIRLIELTQESSKLGKTVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLC1</accession>
    <name>A0A317WLC1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_585695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467337.1">
        <property type="nucleotide sequence ID" value="XM_025615709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLC1"/>
    <dbReference type="GeneID" id="37117852"/>
    <dbReference type="OrthoDB" id="10517347at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016316865" evidence="2">
        <location>
            <begin position="18"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17011" checksum="4E6B7EEE907BD198" modified="2018-10-10" version="1">MKLTAVFCLFAATLAVADPNPDQDIDHGGVVDGLVGGAAQLLGSVVPEQIRPGHARRNVNLNPEPRIGVTVEPKGGPSRRNADSNSPMDLGDPPPNKFATARAPSAVEYPSGGNAKPQLHKSEVVVVSEGGAFPRNADPEPGYEETRPRITRSDWPPPIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQQ1</accession>
    <name>A0A317WQQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_556725</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467456.1">
        <property type="nucleotide sequence ID" value="XM_025613886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQQ1"/>
    <dbReference type="STRING" id="1450535.A0A317WQQ1"/>
    <dbReference type="GeneID" id="37116029"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="57"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY87248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="429" mass="47022" checksum="9A90154D4431A493" modified="2018-10-10" version="1">MLSTLRVASRKAASRDASVRTVIVGARHASAWSNVPQGPPDAILGITEAYKADSFAEKINLGVGAYRDDKGKPYVLPSVRAAEDKVVASRFDKEYAGITGIPSFTKAAAELAYGSDSAVLKDDRLVITQTISGTGALRIGGAFLQRFYPAAKKVYLPNPSWANHGAVFKDSGLEVDKYRYYNKDTIGLDFEGLIADIKAAPENSIILLHACAHNPTGVDPTEEQWRQISDVMKEKGHFAFFDMAYQGFASGNADRDAFAPRHFVKEGHNIALCQSFAKNMGLYGERVGAFSLVCESAEEKKRVESQIKILIRPFYSNPPIHGARVASTIMNDPELNQQWLGEVKGMADRIIEMRSLLRKNLEELGSKHDWSHITSQIGMFAYTGLKPEQMDALAKEHSVYATKDGRISVAGITTGNVKRLAESIFKITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSB9</accession>
    <name>A0A317WSB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_593697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468274.1">
        <property type="nucleotide sequence ID" value="XM_025616188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSB9"/>
    <dbReference type="STRING" id="1450535.A0A317WSB9"/>
    <dbReference type="GeneID" id="37118331"/>
    <dbReference type="OrthoDB" id="5373426at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="427" mass="47494" checksum="E20BDAEEE8CE9764" modified="2018-10-10" version="1">MSRRRASHSESLGLSSTMNEALAYPFSGMQQNNAPQRRGPIEGPNGRRLIRRVTWRSSTYKLMACLWVLGVFYIVWLIRDVFFYPFYSSSNQPLTPKPATDLLAPYLGRQECDISSLSLFSPPPSGDSERVSSNPYCQTRDALLNAMSNGGRHGFDAAYTSQGNLRNTLTDCSRSGCSYRWFTSAEVCNILQKFDGIVYIGDDSLADVYAGFNILLREDLATGSLREWEINKDNDHNCRCESQFTSASCLPLRITSSDEVYAQDSSKAPRRPYTCSSHIPHAFLTTVGSPAPKSAYEKFRRMVGRGAGRNKPVPVLLSLSLSTSYSLPTAKSSMEEWLTLAQASGRNTPFLWVGPTAPGLQKDSGDNIHASSWQYSQDTIQEARNHGFDTLAMYNATLQADSWDGKHYGEKVALIQAMMIINWLSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSC6</accession>
    <name>A0A317WSC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_585668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467308.1">
        <property type="nucleotide sequence ID" value="XM_025615705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSC6"/>
    <dbReference type="STRING" id="1450535.A0A317WSC6"/>
    <dbReference type="GeneID" id="37117848"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016188783" description="Hydrophobin" evidence="2">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="147" mass="14543" checksum="A6B01DE27EBE8679" modified="2018-10-10" version="1">MKYTAIALAALASVAMAQPSARTARGGPLFPAPAGMTVSQGQDTCGDQASLSCCNQANYAGDTTTYNDGILSGLLGNLLGAGSGSEGLGLADQCSKVDLEALDLLGLNDLLNTQCEQNVACCQDSGASADGSLVGVALPCIALGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSW5</accession>
    <name>A0A317WSW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fermentation associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_534279</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468415.1">
        <property type="nucleotide sequence ID" value="XM_025611505.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WSW5"/>
    <dbReference type="GeneID" id="37113648"/>
    <dbReference type="OrthoDB" id="10051416at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029636">
        <property type="entry name" value="Csf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056779">
        <property type="entry name" value="Csf1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048636">
        <property type="entry name" value="Csf1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32085:SF3">
        <property type="entry name" value="PROTEIN CSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25038">
        <property type="entry name" value="Csf1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21678">
        <property type="entry name" value="Csf1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="155"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 N-terminal" evidence="3">
        <location>
            <begin position="886"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="Csf1 C-terminal region" evidence="4">
        <location>
            <begin position="2480"/>
            <end position="3198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY89504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="3199" mass="358337" checksum="5C47A4C3F23637D2" modified="2018-10-10" version="1">MASTSLTTLSLTPDPSFNWFFLLELIVSCILVLFFLLYFNRLFATLLSYGIRAYTWHYYRAYVDIRAIQISLLGGRVFFKGIRYHGVNETIFVHGGFITWHYWRRSLRQMDLKNDKSDHERSEDEAQRPGATNADGSASNSSDREEQGLPKSTHSLPCRITAKLYGLEWFIYNRTPAYEGILAGFTPPPPAPSFTRPQYPGSNTLDPRLKDEKSDVSAGPASDQASALHDDRRESTADDSTTSEAEGSEQEIGESLSRLLRLLPMRIECDKGAIVIGNENTRSVLTTNFDGATGLIEASDSGPLDLYRQVFSFSFTNPVIQMRPNPDFKQNQLAAAKNLGSARVEQSETKRKRDRIFNYQLQKRRVWHSIRDLIPYFQSSVESFHVREKHSDTAPRNSADIPDDTRWVGLSRYLDESSQDDHEEWNPIEYARFSTLVDSPSMTVAYYWDIPGCVKPSSSSPAPPPISPDINGAPPPEWGIDVKIDGGTINYGPWADRERVGLQNAFFPNAYRSSQPVDPLTPGELRKNSVFRLRVEITEELTLRIPTREPSKDWQWKGRADAVRGVSKLRKQSSRRQSRTGDGDKGHIGPDLRPFGWLSLRVAGDSTVNYAMDMVASTSGFHSQLDLDLRETKMLTSVNHALLWQCPRQLVSCDLSVPLTWNSLRTWLFNVDSQDMELFLLRDHIFLVTDLVSDWASGPPQEYYTFVPFIYKLNLSFSDFRLFLNVNDMNIVSNPSDLDDNRSLAIKGTKLTSDISIPLNKYQPEQNAIGFNVKLDDGGIDYLTPLWDTLHAFMKEKSTATLQSLSIDGSYNYYLSTSPELTDTLLLNIDGFSPRLYLFGFLIRSFLTIRENYFGEEMHFKTLEEYQELAYPQEEPGSNGGINPNRKSNDLDVIVHVTVNSPCALFPENLYEHSKCLTLTAPLLEADLRFTNYYMDLQFSLAPLKVALESSETGPRLVPSVPQLFVDGVSIYGHRLFGLPPAEPTYVCNWDFSVGRIIGECSTEFLSCLAAALQSFDMSFDNEENALPPLSLIQLHDVTFLRAKIDSIHISVLLDQTALILRSGSVTTEFDDLANARFSKRMKLLVPDLCIAAIDSQSLGQFGSLLYTDMTPLALFQSTLKIRMVQRRSDITESRRLQQEHIKAHDQRTQRTPWLLMNWDDMDPDSLQYDEDSLVPPTIPIPTMPEPISKHSGLGHLPSSRRLFSVGRSNLSSKSFLVMQDASSVRSVSGRKARQPNRPINMASKIERDQKPRRSATVSPTPTLLKRRDVTKDGLAKTPDASSPWVMPEFSLHKINLDTSQLPSEQVSRKYAAVTRGDLPVVDVDPFFSFSDSDVTTYTNLAIEFPTGIRGFCYPEFLHILSALIERMQPKRPVSIIDSLQKQVISDIVGYEKSMKQPKTCTSIAIRAPSILVKLINSESTPTGGTHLLDEYRIDMSQLKAEFRTKVERERGDLLSGINKSSTVHAAADNLSISVQGNSTDAYQEKAELRCILGDMNFWLVTDPMVRSNFQVRTFDTVTSTRSVEHLASLVRRTTTMSDSIASSFQQSSSLGDRRLQYLIYFLTQQAANIPDPAFLIRISYVLRVARSHLRQHDSWKIISRIRNVYYHMPPDKRQELMAKCLNGDFDLPHDARTVVLSNFDQWRAWDLAHVEKSYVMRRIWNTSPLESEEAPTSMIFSSTVKLFRVSIDPGPKESNFVIEDLSTAVSVQPNEPSYIDKKPRPKEVAVVQSYCSSVSLHLRWEILDLVEGVMKTMSTVTLESAPPAQSRGSGSERLTEIQLVFGADLGSITLDGINIKLAVTGRALRSSLVQKPRSADSPETMSLLLSSEGCYSELSSFSKVLMLWKVSSPHIYCSVVTEGNEAELNHEWKIAGSCRRLRYDMREDLLSLAHTADRLIEDEIRFIYQLVNSMDLPSHQPADAPTPKKQTHNHFHVAMFLDDYRLSFCVLPSLTYVIAGEVARASITPKLGSKIEVDFDLKRNIHTLLSGEGAKWRSLSALEIPPINGRVVADVSSNRTDMEIDVTIELIRLEASALRSLLGALSKPEVSHLIDDLKQSVEVLRLHFNEVVTHTKSPPPQNNPPSSHSILYKARMTMAGTTIHARAPGLNGKSYTADLDISLGMMRLHLDNGLKAGHAMEYPEFHVDTSNISLDLRKEEASRSRSYCSFAIDAKLQGTTTGDSGETRRVFHLTSRRFDIELFPETAALVVDMAAHLQERIKELDLSQEVKRFKRLRHRGHLEKKGLEVPTIQVEDAGSSEGLFDAMYSLDFNDIQVGWNMATAPSRVAARKPDDLVFSIKRVELSNKRANAAKLRIEDVQLQMVPISGNRRKRSPNSALLPELVFNVAYSSAGKEVRLAFQAAGKSLDLRATSDFILPASVIRDSIASAARTIREANATLVTKPSDDSTKGRPLFGNKRFRSVLIDVDFAGAIVSLQGRHTDDPQTMLTANMKDARLPGSTYGQYVQDGMATATFRAPGVALKVQFEDNGRDNSALNAELKVDASTNVLYPSLVPLIKQMTATIKEVMGDQPKPRRPSNAVMLQSQKLMQETPLDDKGPGSILGRCKVNVGILICKQEFSLSCQPIARVAATTRFDSVYVTVNTVQSDDHERFLALLVAFNSLQASVKHVYSNESTASFEVESMVMSLMNSKHLGRSKGISVALRVSPMEVALNAKQVQDLLLFREIWFPSSDDIDPGPPPEPQPTETQAYIVQRYQQVAAAPAFPWNTTISIEKLEIQLDLGSTLGKAQFAINDLWLSSKKTSDWEQTLSISFNTLGIESKGRMSGLVELQSLKVSTSINWPTDRQNHQTPLIQASISWHQLQVKVSFDYQPFLIAHISSFAFLMYNVRPTVDAPNERLFSILDGDKVQVFCTSLTASQSLALYQAWQRLVQDKQAAYEASLRDVERYLRRKTSTFSEKTEVSSREISKPAEDKAETAPISLHTGVVVSINAVSIGVFPSSFFDNHVFKLEAHNAQARFDVSLQNGKIHSALGLTLGQLRVALSNIVRSGPMETEELLVKEIANRVTGSRGGTILKVPRLLARMETWQVPGSQQIDYIFQSTFEGKVDVGWNYSRISFIRDMWETHSRALASRLGKPLPPSAVRITGALNAEGGGDKNEPQEKITAVVNVPQSKYTYVALETPVIETPQLRDMGEATPPLEWIGLQRDKLPNITHQIVIVTLLEIAKEVEDAYEKILGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSY3</accession>
    <name>A0A317WSY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_623460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468360.1">
        <property type="nucleotide sequence ID" value="XM_025617155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSY3"/>
    <dbReference type="STRING" id="1450535.A0A317WSY3"/>
    <dbReference type="GeneID" id="37119298"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY89449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="557" mass="63355" checksum="F0EF9D23FBFDFEDB" modified="2018-10-10" version="1">MSTLETRHLKACRPCSKAKVRCDPGPTDACHRCHRLRKECIRQAPKTHTVRKNTVSSDVGRLERKLDNVTSLLTASQRYMEFNGGSYSPLPASKITQGDSPQDELVEKILASFNQRITRFFPFIVRSPPLRASDLHNKKPFLNLVIPAVVCEDATAQVGQALKARDYWMEHMIANGEHSLDLLQGFLAYVGWTQILPPPPRAAQINNYLHLLEAQVINLDFYGDNRSVIPGTVFSYLKVFGLDGNGRNSRTLEELRAYLGCYYLVTVVSLCLGEREPMQYTSYTDECCRTVKEAAQCESDQYLVQLVRIAHMAEKIYRAVQYQEVDTPVGLAPTAMGIRWLQRELQRLKDSFICDAPQSIILHLHYHTLELLTYRVALERDFSNTTLSNYPLTQIDVLCSCLNSTRSFFDTLFYLPTNLYFQLPYTCWTQVGHALAILSRLLVHHDPSGYWDREWAQQTINFDDIVTTFTLKVEEAVSYARAENISIPPIFTHIKKRGVLWKEAHQMRCAAMDRWRQEHSQLSEPGAAAPAAAADGIPDVSMEDLLAMGPIWNLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT00</accession>
    <name>A0A317WT00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467831.1">
        <property type="nucleotide sequence ID" value="XM_025611688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT00"/>
    <dbReference type="GeneID" id="37113831"/>
    <dbReference type="OrthoDB" id="5422688at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="345" mass="38909" checksum="B98AC70FB2E70BA9" modified="2018-10-10" version="1">MMLSALRHWAPFQIDALGLVTMLGADDINLTVGRLVYSRFTEYLPVLGAFIIANNEMTKPIPGFVAYNITDGIMATDVTGWFSRWLLCQDFTTCSTTLRLVVQPKSNLVKRDAIGLFIGILSMAPVIIFPVIMGDWWGFVNSMSMLISIIVRKVIVHQNRTAISRSALQAYDTSSEAVKTFWTLPTGTVVTIYTPRGVLTNTLLTNPRPGHPRLYKLMRAIGWVGFGCHVISLGMTTLFNQIVTVAVLLVSTVIVVHRIGEDEHLIGENIAVSRHDDLEEQFRAATYARLELSEKEEQSMVLWNLFPHESNTAWWVRYRDCVQRGHGAFKGWDRKLTQQFTESEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTW3</accession>
    <name>A0A317WTW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_623791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468074.1">
        <property type="nucleotide sequence ID" value="XM_025617173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTW3"/>
    <dbReference type="STRING" id="1450535.A0A317WTW3"/>
    <dbReference type="GeneID" id="37119316"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="69"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="548"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="689"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="509"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="649"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="567"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY88712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="744" mass="84171" checksum="E3EBC92DD1BDCC32" modified="2018-10-10" version="1">MVKRKLGALEKVEADLPNLQHKIRRDPKSYIEDFRAQHYQYESHREIFMAAPSATTETGLISLRELIDFLAHVADCYPEITKDFAQQLIDILTQHHLILQPELREKIVGSLVLLRKKELMDSATLLQTLFPILISTPSKTLRALIFQKILMDLRSSNAKTTNHKLNRTMQTVLFNMVTSDRKSSKGLWAIKLTRELWKRQIWTDAKAVEVMKEASLAENEKVIVGGVRFFLGGDKEREEMEDESSDEEAIDLGKVKHQVGINKKTRKKSRAVEKAKATVKRKERKKNQPHPLNFSALHLLHDPQGYAESLFSKHLQNTKSKLNLDQKLLVLQLVTRLVGLHKLHIMHLYSYFQKYLTPRQPSVTSFLASLAQASHDLVPPDDLEPLVQKIANEFVSEASASEVASAGLNAIREICVRQPLAMNETLLQDLVMYRKSKDKGVMMAGRGLLSLFRELNPEMLKRRDRGKDASIGLRSGERKEKRFAEQEAGGIEGLELLEKWKEEERRKRRAEKGLASDASDDEDEDEEENDWAAWNLEDDEDSDDSGDWVNVQSDVEIEFSDSEDEKDGPPTKKAKSTDDTKVETKPEETAEAKFSKLATTRILTPADLAKLQELRTEAAVNALVPGSKGATRHRDDPLTAEEIEGLAALSAGKATREERIAHAKEGKTDRSEHKSVTAKRKERKEDQGKSTTNKEKARKKNFLMTLGKAKSKNKRSLVQTRAVLKAHQDRAKRGGRRGNVGAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVX0</accession>
    <name>A0A317WVX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468877.1">
        <property type="nucleotide sequence ID" value="XM_025611442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVX0"/>
    <dbReference type="GeneID" id="37113585"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="53" mass="5588" checksum="AA3D01E386923B6B" modified="2018-10-10" version="1">MDAIMQDHLIPRPGELSGNQPIHSTGPNPGPAVLHSTSPRRRAVGRPAIALPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWY7</accession>
    <name>A0A317WWY7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_28784</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468923.1">
        <property type="nucleotide sequence ID" value="XM_025606681.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WWY7"/>
    <dbReference type="GeneID" id="37108824"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001576">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="1914"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="5">
        <location>
            <begin position="1931"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="915"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1835"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1948"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1472"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="915"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1006"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1026"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1840"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1948"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2066"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2106"/>
            <end position="2117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY90545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2117" mass="236797" checksum="3C4DA58EC39D8641" modified="2018-10-10" version="1">MEFMDIVGELQSLPDRVHILCPRQHDDDHARYDDVSQVDESGRSVAELVSEANNRKEKFLSCMRILAYNQEGVEELQNWIWRKLDDSLEKCDLCIKQYYTGKIWLMEQLKENYDDEDIEKFSRMLDEWDIKRITKNLTSATAKLKEVPSQEIGLHVLDRASLLSIFESLSCDAMLRNGSLLQEYFDEPFRLIQTKRSLKVSDYIPAVTRFLFDPNQNRSFWAIHSWMRYSRPPTTMEFDWAVKEGLLDALRTASQQPTQVAVIQRLWRGMQLVVRRLDKDQITHHLRALEIDPCRLSVDHLGIQSPGLRFLLNTIQIFLEKAPGDFWDAMQTISPQALIELVFYNPQLDAFLMQATEGEPFEKSAMKDMLSWISPFMSSLKGAHQPSACRSLVQQLLVRLQDVRFPNLARYHCFNTGLAILLHTLRSFTDHESSRGSVERVVLSETLGVVSANIETILKPPQFAVEQGRQREIASLCMDVIRNTLALECQSLKSDYEVILRHNTLQHGVSTYSATIWDAVVKHLHEDNLALSTSALLGILPLVGLEKFPTKGESSPEKTHFNVIYGHLTHLSCQIIERLADFRPEHLDELFKSQDTSSALISALFAADLNTYQSAVDLIKNVSGQSARRDAISHLLQSFFITTMYGLSWSFRRISNMKTFASAPRMIHTGTDIVDILCDSQTGMLRTRKLADRREVLSLQKLWEYLWQALTTIFDETESWHLRGNDKAVMLEFCRDTIQFADLLFSQYGVFLSAVVDADPNQEGSARENFLKSATTTMSAMVKWLRLKDEYLATTLVGLVSKILRRLGELSVTTVKQDALSFIEGVAVNSSIKTILTLREKAELVRALEAYYKKPVVTASTASLKKQSMITAFTKPADLSATPSPPKPTDEFDDSVPDDVLLQLSRSVELNKERVASEAKKKADKAAKALPAIPRPSPAPLRPNVTIQAFREKREKEREAKKKRDMAELARLKKSLPALGVAEQTAEQGSGLSGIGIKGKDHTPAESMMVSSGSESESESEDELDKELFGPKSRKPDAVKAYEESKRMSLKQQGPVKKIKQLRSAKDMRARLAPDLSSLHRTILAWDFFANGDLPPNSGRTDYTLVSNAFREPTEYQRTFEPLLILEAWQGFQSSKEEGTFKPFEVKVATRLSVDSFVEVSTAIPAMEAKEFGLGEADIVLLSKASSPTIDSSAPHCLARVSGIKRKKGTVEISYRVNPGNPFINSLGPGATIWGARITSLTPLEREYGALMALQYYDLCEEIVKAKPSPILSYSDASLKSIADNYNVNSAQAKAIKSALDNDAFTLIQGPPGSGKTKTIVALVGALLSSVLGNSGVAIARPGGMNNTNPIGGRTTTSKKLLVCAPSNAAVDELVMRFKEGVKTIHGRQEKLSVIRLGRSDAINSNVLDVTLDELVNQRLNQSARKDHGERDLQKIYMEHKAADTAFKETRARMDQCRAQGLPVPAELEREFDLLKKKKTQLSQEIDSARDKNHSAARDAELTRRRIQQEIIDGAHVICATLSGSGHEMFQNLSIEFETVVIDEAAQSIELSALIPLKYGCSKCILVGDPKQLPPTVLSKVASKFQYEQSLFVRMQSNHPRDVHLLDIQYRMHPEISAFPSAAFYDGKLQDGPNMARLRTRPWHQSELLSPYRFFDVQGLHQSAAKGHSLINIAELRVAMQLYERLMTDFRAFDFNRKIGIITPYKGQLRELKTQFAAKYGNEIFNKIDFNTTDAFQGRESEVIIFSCVRASNKGIGFLADIRRMNVGLTRAKSSLWVLGNSQSLVQGEFWGGLIKDARRRNVYTDGDVLKILQRPQFTGYQNIEMLDADAQESAVPSRATSSAPISRHSSASADNSSSVSVSRKDTPPIPPDGPSGGANGLDETRTCGYCGSFAHMTHHCDNIDAKEATRGTCYRCGESGHTQFYCSVQRCVDCGQIGHVSRECRSTKTLPKHERSKIAREEHNRTQNQKQRTERQRLRQLGGHDPKVPIVQATPSDDSNGPGKRKRKDSPPTDGSKASRPRNHNPNAPPAGAPKGPRRRIDANIPSNTEGLVRPSRDGPAYAPLDKDKPFNDPRPGRGPESPHPRSGPPRPGNGARPPPMRKKKEADPFIRPKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYX5</accession>
    <name>A0A317WYX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_533732</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469322.1">
        <property type="nucleotide sequence ID" value="XM_025611387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYX5"/>
    <dbReference type="STRING" id="1450535.A0A317WYX5"/>
    <dbReference type="GeneID" id="37113530"/>
    <dbReference type="OrthoDB" id="16911at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="74"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="292"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="437"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY91594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="676" mass="76195" checksum="2DF6C229EC3C6464" modified="2018-10-10" version="1">MDRIRQTLGLAPDLLAWRALRGPRIPSTVIRHPLWRCRSTIASDAFDAASTAPPAPPAIVLRDYQEECIQSVLYHLDQGHKRLGVSLATGAGKTVIFTQLIGRIPPRDGRHDQTLILVHRRELVEQAARHCRLAYPDRTVEIEMGNSVASGSGDIIIASLRSLTSGDRICKFDSRRFKLVLVDEAHHIVAPTYRSVLEYFGLDDPSPDSPALVGVSATFSRFDGLKLGAAIDHIVYHKDYMDMIDEKWLSNAFFTTVRSEANLSRVRKDKFGDFALSSLSEAVNTNKSNDITVRAWLANAQDRKSTLVFCVDIEHTRQLTEAFREVGIDARYITSGTPKDMRDEQLRLFRDQEFPVLLNCGLFTEGTDIPNIDCVLLARPTRSRNLLIQMIGRGLRLYPGKKDCHIIDMVATLDIGVVSTPTLFGLHPDELLENAKAKDLRDKKETAGGQYTEQPPETEIPADESDVSDDIKITFTKYDTIYDLIHDMKSEKHIRSLSRFAWVRVDENKYTLSDSTGWITLDKEKPSPSNQNANDTSASYTVHHVMKFKSTTETTQYTRPRLIATATDFESAVHAADTFAASEFDERYISTRQPWRQHPATAAQVNMLNKAKIRNGRIAPGDLTRGQAADLITKLKFGGKKRFDKTQKRRRAFDDKAREMAELRRREEVRVGPVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZU5</accession>
    <name>A0A317WZU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_564583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469611.1">
        <property type="nucleotide sequence ID" value="XM_025614436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZU5"/>
    <dbReference type="GeneID" id="37116579"/>
    <dbReference type="OrthoDB" id="3645574at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="148"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="502" mass="58383" checksum="8FFF59DD7C32CFF8" modified="2018-10-10" version="1">MPTSRPLLRGEITYSTAQKKEVNILHRLSYHDQRERFFAHVVERRDWIEAIVAHHLNLGSPNSCYMDDMENWHHGSFNICVPVTVNDWKRKEQPGKRVLLRFPLSYRVGDAFRPGNGDEKICSNCPDVPIPKLYGFATSTGQTFTRLQDLPTFTRWFQYVRRRLLSWLGRPVPTQFVCHQAAGNISQNRVMGAGYLLIEYIEEEQGEMLSNTWPEKQLDAGLRTNFFRDLSRILLSITRIPLPKIGSFTIDPNGFLQLTNRPLSIGIHDLENDKIPIDIPRDYTYSTIDSYVTDILRIHDSRLRYQPNAINDIGDYIYQTSALAAMRTTFPSFFKSELRRGPFTFMLTDLHPSNIFVEKDWCITCLLDLEWACTRPIEMLRTPTWLTNKAFIDILADEEQKLRSKISPVTQPSLSVIMKDGWKKGTFWHSLALASPTGLFAVFYKQIQPRFLENCPDHDTFQQIMPWYWAHDWVNVAASKLSDKKEYDIELRKAFETDPSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZW1</accession>
    <name>A0A317WZW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetratricopeptide repeat domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_555076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469637.1">
        <property type="nucleotide sequence ID" value="XM_025613767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZW1"/>
    <dbReference type="STRING" id="1450535.A0A317WZW1"/>
    <dbReference type="GeneID" id="37115910"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7779" evidence="1">
        <location>
            <begin position="354"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="822" mass="93733" checksum="08034E98910443F2" modified="2018-10-10" version="1">MFGLTPCLFIKSIDHRELPRFNNLLNFYPIQRRHEYAMTSEVLPEAEQMRLAEGPSNMATEGIPLDVGSIHPATPRTEIRKALDLPCYLLDKPYANEYFCGREDILERLAVELLPSKTVDTALGTGLWQFALCGFGGVGKTEIAREFCRRYKACFDAVFWDLADEIANLDHRYQQIALALGLEDSSECKSQFASRETVRGWLSKPRKQTLESNELGQVSQDDSEANWLLIFDNADDITILEDYWPQGNGSILITSRNPSAKSLLTQRPSGLDLGPLSRKDSIILFNHLVTVSDELEGTTTRQTCTPLAISQMAGIIRRQDLALSKCLELYEDHEEHASLYESNFYTNMVTYSQIRQLLELITFFDPDVIQEEALMKASMYMNGEGIHYNKSNYIEARSDLLQSSIIQRDEEKQQLSTHRVVQNLMLILMDFSRKSFMFDNVVRILWAVWPSAMPQPSKEPDLPKPKSSGGRLLIERWPICAAIYPHVLRLHQLWPGIANPSEATSLLFAKLLTEAAWYQKERGQTRHFDGFFETAQNICDSSTHPDRDSLLADIHFCLGSIAMDTNDFNTSRSHKERSLDIVSKICKDLNTADEKLYLAYAERGVSRIQDKRYEEGEADLKEALRIRKALGNYVPRSAEAHLSHALLAQGKLEECDTLLLDSLAGREKALGRDDQESIRTGLILYALGSLRAKQNQWDESFTYHQRAWQHMRATVGEKDIYAINAAHKVAEHHFRLGDNQNAIAIITRALSTLSVDQIAHKNQIARTSFLEGKVYEAMGEKHEASHPFRVAYWFRKEITNEDRDIKSLTMDDFDEIVAFWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0K9</accession>
    <name>A0A317X0K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
            <ecNumber evidence="5">4.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP pyrophosphate-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Adenylyl cyclase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_583742</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP = 3',5'-cyclic AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15389"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <dbReference type="EC" id="4.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469543.1">
        <property type="nucleotide sequence ID" value="XM_025615579.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X0K9"/>
    <dbReference type="GeneID" id="37117722"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17214">
        <property type="entry name" value="RA_CYR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000408">
        <property type="entry name" value="Adenylate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000055">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000220">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000305">
        <property type="entry name" value="Adenylate cyclase AcyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013716">
        <property type="entry name" value="Adenylate_cyclase_G-a-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055071">
        <property type="entry name" value="RA_PHLPP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08509">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23010">
        <property type="entry name" value="RA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00789">
        <property type="entry name" value="Ad_cyc_g-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0115">cAMP biosynthesis</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ras-associating" evidence="19">
        <location>
            <begin position="409"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="20">
        <location>
            <begin position="1197"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="18">
        <location>
            <begin position="1533"/>
            <end position="1670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="26"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="888"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1905"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="930"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="966"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1905"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1917"/>
            <end position="1929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY91815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1947" mass="216867" checksum="F78F62CDD98C3897" modified="2018-10-10" version="1">MTVSSQGSKSSAGALFRKKLQGFFGDEYVGNGESRHDSDNFTQSSATKPSSLDHFRARERANSDGSRNSGASQAQNQARSQTPLPSSDITPWLYQSYHDIPQYGEAPVREAPTAATDSQRGSISQKDQSRRHFSGHRHSRSKEEKPTAAGDLAGYSSRPATGRDDLSLELRPSREGSLNHVTPMTSSTTLVGRSTSPTPSVQSAYSREQGQNSPGTQTSKRSFLDKIRRPKHGHLKNITGSKTVQDTTKAASSKLSRREASPARRGRQGSIESGTSSRLTETGDSERRKDSKGLAISSTKLRGRRGHGNEFPSAVELRKPGVPNMWALDTDLTHMEGIVNPPSPGAQSKMFDGASIRSEETRRPDTMPAGNWDAPESWHVKKNEPSNLLPQDTSEPGPTISEPGGSNWYIRVFRQDATFATLSGGLYSTVSELVQLLSRKSFFSDPTANYELIMQKNGLSRQVDQTEMPILMQKRILEQVGYTEKDRIEEVGREDHSYILRYTYLPIRISGSVIEGHDPPLGKTQQKFSHVDLTNRNLLTIPIGLYKKAAEIISLNLSKNLALDVPKDFIQGCINLREIKFMGNEALRLPASFGLASRLTYLDVSNNCLEDLTHANLDRLHGLVSIKLANNKLTNLPSYFGNFQYLRSLNISSNSFHVFPELLCRLKNLVDLDISFNNISGLLHIGKLTTLERLWMTNNIVRGALDDTFRDLVNLKEIDARFNEVTNIDILCFLPRLELVDVGHNSISKFKGSFPKLRALGLDHCPMTQFDIDAPVPTLRSLNIASAKLVQFRDSLFDNLPNLQRLILDKNHFVSMSPHIGKLRKLEHFSMIKNPLAALPATIGCLTELKYLNLRECNLRKLPPELWHCLRLETLNVSSNVLDVFPKHGCPQPQPPSEVAGTPAATPGISTTPSYEELGALEEQEARRPSQASGGALSTGNSPNGGTYRKPSVASSLGQGRKVSAASRSLTDGSPSSRKDSNFSQHVATTFAGSLRNLYLADNRLEDDIFRELSLIPELRIVNLSYNELTELPQGLLRRWPLLTELYISGNELISLPSDDLEEGSNLKVLHINANRFQVLPAELCKVAKLAYLDAGSNSLKYNVSNWPYDWNWNWNRNLRYLNFSGNKRLEIKPPGSSLSNHPQSSKQQPPYLTDFTSLTHLRVLGLMDVTLTITTIPEENEDRRVRTSASLAGALAYGMADFLGKSDHLSIFDMIVPRLKPDKVETVVGMFDGQSQTGGGSRIAKFLHENFVHTFNSELKRIRSEQHETALDALRRAFLTLNKNMAFACYKSLDQDVRQYQEDSTDQRRVRLNKDDINQGGVATVMYINNMDLYVANVGDAQAILVKSDGSMRHLTQNHDPAEAHERERIRAAGGFVSRTGKLNDVLTVSRSFGYFHMMPAIIAAPHTMHVNLTEQDEMVILASRELWDYVTPDLVVDVTRAERRDLMIAAQKIRDLALSFGATNKLMVMILGVGDLKRREKIRTRPSLSMVGPPEEQIIPSVKRTKKPRDAPGDSRLARFDYVDAPVGELAIIFTDIKKSTSLWETCPDAMRSAIQIHNDILRRQLGIIGGYEVKTEGDAFMVAFSTTTAALLWCFNCQTQLLEAEWPTEILEQPQCQVVCDSENNVIFRGLSVRMGSHWGEPVCEKDPVTNRMDYFGPMVNRASRVSAVADGGQIFVSSDFMSDIQRNLEIFADSERAASTGSEESYAFDTLGNNIRRELQQLNSQGFVIKDQGERKLKGLENPEPLYLIYPHALSGRLTTVDKDTSNELAPTTISKHSQLEIQTDLIWRLWEITLRLERLCAALEYPGEALLKEPNVALFNVVKNHGGELADSTVISLVEQQVTRIEVCITTLSVRNMIRPFRPGDRLNDHAMPIADVMQQLQSQLTEYRALKEQIDASAGTATSYTHDPQYSNGESNSDSASSSYLQMGPPSDEFNPGGPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1B0</accession>
    <name>A0A317X1B0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_622831</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469110.1">
        <property type="nucleotide sequence ID" value="XM_025617105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1B0"/>
    <dbReference type="STRING" id="1450535.A0A317X1B0"/>
    <dbReference type="GeneID" id="37119248"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF160">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="41"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY91382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="510" mass="56032" checksum="8C90CE1E5EF9402C" modified="2018-10-10" version="1">MMFSFLVKVNTEPVCEFPDFRDKMTTKVDPRLFPRRVRYAALLTVNIFVFLGNMYSSGIATGFDSLAADLHVGYQNLSDLISWSVLSMGLANLFWMPLALCFGKRPIVLVSMAMFVAGTIWTVVAKDYNSLLGARVFASFGYGSIESLGPSILADMFYERNYSSAMALYALFLSAGSQVGPLIAGYLVAARGWRWFFILCLIVAAVNLVTTFFFLPETLYKPSAEDQLEVEDKEKHDIFQSHIEAVAEASAGRQPQQERFSYGDHWKGLFKVGLSDAAKEKGLFKHLAHMFWLPLPMLLVPGVLLASMMYGVVLGAVVSISTLSADLFSPPPYNFSSAALGLFALGSFVGILVVWPIAGPLTDGLSNYLRTRNNGVHKPEHRIPALIVPFLISPVGLVVFGYTVSRQMQYVAPAAGSAMSAAGLTIVPSVMLSYIVDSYPHTSAEALVLVNTSKNVVAFGLSKGSVDWMTNQGVDKMFYEFAGIQWAVLALGVPLYFVGPWIRKRTSKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1J7</accession>
    <name>A0A317X1J7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_555303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469200.1">
        <property type="nucleotide sequence ID" value="XM_025613782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1J7"/>
    <dbReference type="STRING" id="1450535.A0A317X1J7"/>
    <dbReference type="GeneID" id="37115925"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="759"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="859"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="836"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="878" mass="96534" checksum="D7FFF9517CE0214B" modified="2018-10-10" version="1">MEHLRRSRSSRSIRRSHHSSQSTEPFDPELARLHATTAASRAMLRSKCSYDALGGPSNMAVPQRKHLPAEPPQKPNNVPIGPGNPHYRYTADNMDTSNTDPSLSAALPSISEFRGLDAGVAALPSSYRRLRKTRSMFSTGQRYSRGSFGMPSPESFNKGLAGKADSQDGPRACGTLRRSMSFFRGDSRASDALRHAKSHDAAIELARSHYQQSGDHPYQPRKSSLSIPKLRREHKPFRKTLRSAVSDADAASTPSSTQRTTTSSYGKARSLSSSIKKGIKKVLGLSKPPVHLHAERSSSFDQKRTQDIHSTVSGMHTDSLKNNVGTADLTRLGGSEGPVTHHEVKRTGSSESLATSRSRVTSWADSTIANTIVTPKAGDRSSLSIIDERESSIPQPESSGDNSITTWSPPRPDGMIDSQRLYSALMKRIDGNNKQNASEEIILGHVKEHRAIPTPAPSMYTRRSRQTIRLIASDESIQSPGSYTTAYAGTTTPRQSSQRVVQRTQGPQHLQKSEVCNPYASGELDPSIRATKETLGEDAKGVSLERPRSPDTELDSPSVYSRTTSGNSPSTMDLKIDANGPDATEEPGMATIFASQRAAYSSPKRSLGQGPVGSQRPSADWQQWMHTQMARIERTENLAPTRCHYREDAQIHDEGTAFAYRTPARDTGDFRHGLLEDDMWTTCKVSAKNNFSRPFSRSSSIRTTVAAPRERSNTPLPPPPPPISTSPKISSSSSGHSFLINQIETRPNSIALSPVHLLSNSRSRAPESPTPRRDAADKNQWQATSRKQGRYSSRQLPGTRDLKAFQGRSARAVRDNRRLTDENLRAENGYRDDTNQDSPLQSTYSPISSKRMVEMFLESRRQRGTEVPDEAASEGAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X395</accession>
    <name>A0A317X395_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_544082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469794.1">
        <property type="nucleotide sequence ID" value="XM_025613163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X395"/>
    <dbReference type="STRING" id="1450535.A0A317X395"/>
    <dbReference type="GeneID" id="37115306"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="436" mass="50705" checksum="F5867451B6126F29" modified="2018-10-10" version="1">MDSANPMTTVSRRSKPKTRTGCLTCNSFPRACRFRRVKCDEQKPSCLRCLSTKRICEGYPIISRPTIAITNHLADEERRAFSYFRSRTAHRIFGEQDANEWVPVILQIAHIEPAVRHGITALASLHESLEPVNNQLTWLRQTPQDRSLSAQMLALRHYNHAIQSLRSESIVMSSRPDITMILCILFLCFEQFRSGDAACLVHMTAGLKLIDWWRSRTDNYTKLKEYSRPTLEFMNEKITPIIQRLRVQFSLCMDSRHRWGRYGVTYGLPPTIPTCYSSFDAARRDFDRSMSYMFSVLENNQVTYHQEPARDPITILRQWKNSLDASNLFSQTTHLQGCSRRLLELYYHVSIVITGTYYTEIETAFDKYLDQFQAIVDLAEQIAIDWQHATKEYSLMFSFDLGLTPPMFLVASRCRHPDIRRKAVRLMLESPFYHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4F8</accession>
    <name>A0A317X4F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF1750-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_564558</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469566.1">
        <property type="nucleotide sequence ID" value="XM_025614433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4F8"/>
    <dbReference type="STRING" id="1450535.A0A317X4F8"/>
    <dbReference type="GeneID" id="37116576"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046464">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="4">
        <location>
            <begin position="259"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="577"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY91838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="677" mass="73904" checksum="999DF2BBDAAD2565" modified="2018-10-10" version="1">MDDPASRVPAQLLPHMHLVSRHRYPLMHMMPTDTVVEYLLSASKIVRETQPMHWTFLDGPQDGTVMLTWQPLNQLGTNFASDGYVWADVEQAFTFEARGYMVEMWLHRSGYHPPNEPVAMHCRRRYRLLPSKVPNPNVPPPDPSLWIVHYSRSPPSEHVPANRIPVLPQVQNMLAQRRFLQSQGQLARKDFMLHDRNNWPAINFPPQMAPQGFPQIPGAYPSAMVGRQPYYPPPGPGAARGHRASSAAINAATADFALEDEDISTGDTMDLLTPREISKMRYQQHHEWMEEIFASPYAINQITPVSLGLGRKGELESLTAGFFDAPIGPANGETKDASASAQAEKMEPAKAEEFADRVAKKVADMTAEIEKLKKRHARRMEKFNRTSLLKDAELRLREAAADPADTGAETWRLEGRVVMPTEDDDSQAPQVENPAKFKVDDIVREVEKSWQRPIVPEPKISCVQKGGLLEKIEPEHKPEVQVEGDIDMGNANSHFLDQLGSPPASGAVQIPSTAQAPPVAPTVPPTTGVPTGGVSMPPQPQPTMNTTQQGASLDIDMDMGDGQPSNTAAGETGDWVMVNDEKKDQPVAGDSSLAGIGTPGSGMQGLTPGNGGSAGDSALDGANFDFTNMDSAGDALAAYSEQNDGLDLPDLENSAFGDAFHASDNENTHHHDADDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5J9</accession>
    <name>A0A317X5J9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear polyadenylated RNA-binding protein Nab2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_564541</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469548.1">
        <property type="nucleotide sequence ID" value="XM_025614431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5J9"/>
    <dbReference type="STRING" id="1450535.A0A317X5J9"/>
    <dbReference type="GeneID" id="37116574"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.40:FF:000001">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.30:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.40:FF:000002">
        <property type="entry name" value="Nuclear polyadenylated RNA-binding protein Nab2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.40">
        <property type="entry name" value="Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055046">
        <property type="entry name" value="Nab2-like_Znf-CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043094">
        <property type="entry name" value="Nab2/ZC3H14_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22683">
        <property type="entry name" value="Nab2-like_zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nab2-like CCCH zinc finger" evidence="9">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="454"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY91820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="494" mass="53310" checksum="04BBEF2BB1B567E6" modified="2018-10-10" version="1">MATMVAAGTPLAEALGHVIPPKLVEMGWSSDGGDDSALTEYVILMLVNGKTQEQIAGELSNDLLGLGEGDTQALDFSRWLFEQVEVLNHQINGGGAPVPNAPASAQAIPSFADQDATATQMTGFDGSVQDTDMSMGDGTPGDSIPTGPKAMRSGRGGGRGRMLNQINRTMDRGDSALHRVRGQAGAGRINSHGREHGKGRFNQNGGARMPGGRQMGQMGMGNMMNMTQSDQMHLMSLLEEQARMMAQIMPGFVPPAINPAFQQNGSPQGRSLFDRVERQRGHRHHGNRGQRHNQHDQSGDVDMDTKPDQGNQDESNTDSVCHYNLRCTRRDCPFAHQSPAAPEGAPVDVSDPCTYGAACKNRKCTGRHPSPAVKTAHQAEELCKFFPNCANPHCHFKHPSMPLCRNGADCTTEGCKFTHVQTACRFNPCLNPNCPYKHAEGQKGAFSDKVWTANSQEGSHVSERKFVAEGDDETEELIKPDTAGDGSQSHEIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5R4</accession>
    <name>A0A317X5R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Na/K ATPase alpha 1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_553792</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470670.1">
        <property type="nucleotide sequence ID" value="XM_025613677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5R4"/>
    <dbReference type="STRING" id="1450535.A0A317X5R4"/>
    <dbReference type="GeneID" id="37115820"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005391">
        <property type="term" value="F:P-type sodium:potassium-exchanging transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006883">
        <property type="term" value="P:intracellular sodium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000114">
        <property type="entry name" value="H /K ATPase alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="853"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="923"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="986"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1024"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1055"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="11">
        <location>
            <begin position="100"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1094" mass="120259" checksum="068E8AEDCE21B537" modified="2018-10-10" version="1">MDEKPTGAPNAEATRLRWQPVDEETGLQSRRDPPPLSRTISAASNSSARSRARRATVDPSLSLPIHYRTVSFDIDEVRDRERAEATTTKNNVATDLSNLNWHKISPEEVQKRWRVDISQGLSSDQIQQRVREFGKNALSPLPHHWFWQIFGYFFKGFGAILLIGCVLVFISWKPLGQPPAAANLALAIVLLAVFFIQAAFNAWQDWSSSRVMASITAMLPESCLVLRNGSLNVVSAPDIVPGDVVHLKAGNKLPADVRLVGVSNDVTFDRSILTGESLPVNGTVDSTDDNYLETHCIGLQGTHCVAGSAIGVVVSTGDSTVFGRIAKLTSEPKTGLSTLEKEVLRFVLLIVLIMLAMIIIVIVVWATWLRVDHPGWINVPTLIVDCVSVAIAFIPEGLPIALTANLTITANLMSKNKILCKSLKTVETLGAVSVICSDKTGTLTMNKMFVTDCALSTSCFSTDLARDEMVVKGRRTGIHQLRGIAGLCNAAEFDASSMSQPLHEREIYGDATDQAILRFSEGLGSVAELRHAWRKTYELAFNSKNKFMIRTFSPAGSGGLSFAMSTAESAQFKLNDTLLTIKGAPDFLIERCTQTVDTDGSVQALDGRILAHIKNVKDQWSGEGKRVILLARKVIPASDIMFPPSSREFESEAMNHAKTGLILVGLVGIVDPPREEIPDVVRTLRRAGVRIFMVTGDFGLTAVAIARQCGIVSTQGPVDDASCLQRLDSDDEKPPGTPCSVAITLSGSELMSLNDYQWEQLCQYQEIVFWRTTPEQKLRIVREFRARDEIVGMTGDGVNDAPSLKAADIGIALGSGSDIAIEAADMVLMESFSAIVEAVQYGRVVFDNLKKTIIYLLPAGSFSEFWPVFTSVVFGLPQVLSSFLMIIICCFTDCAAATVFAYEAPEADVLLRPPRKPNHNRLVNWKLILHAYGVLGLIETATSFAMAFWYLERNGIPFSALWFKFGANPDNIDPEWLTARLNEASSVYFINLVVMQWFNLMAIRTRHLSIFSHPPAFNKHTQNLLLFPAILFALGMAVFWLYIPPLQRVLGTSSVPVEHYFLPAAFGLGILVLDELRKAGVRRWPGGVLSRLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6E5</accession>
    <name>A0A317X6E5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Cutinase</fullName>
            <ecNumber evidence="3 12">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_543182</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3 12"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470656.1">
        <property type="nucleotide sequence ID" value="XM_025613125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6E5"/>
    <dbReference type="STRING" id="1450535.A0A317X6E5"/>
    <dbReference type="GeneID" id="37115268"/>
    <dbReference type="OrthoDB" id="3225429at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000235">
        <property type="entry name" value="Cutinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF3">
        <property type="entry name" value="CUTINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00129">
        <property type="entry name" value="CUTINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 12" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016193159" description="Cutinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="47"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="188"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY93895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="260" mass="26371" checksum="988DE41A9289B81F" modified="2018-10-10" version="1">MAPLKSLLLTSLATMATASPLIADPSSLHARQFGTGITANELESGSCKEVTFIFARGSTELGNMGSVIGPPVCDQLKSKLGSDKVACQGVGGGYTAGLMQNALPQNTDPAAISAAKDMFNMANTKCPDTKIVAGGYSQGSAVIDNAVQEISSEVRDKTVGVVLFGFTRNVQDHGQIPNYPKDDVKVYCAVGDMVCDDTLVVTAMHLTYGVDAGDAASFLVSKVQAAGSSTSSSSSSDAASSSSSASSSGLGGLSSMFGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7N2</accession>
    <name>A0A317X7N2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Replication factor A protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_532234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471056.1">
        <property type="nucleotide sequence ID" value="XM_025611082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7N2"/>
    <dbReference type="STRING" id="1450535.A0A317X7N2"/>
    <dbReference type="GeneID" id="37113225"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000271">
        <property type="entry name" value="Similar to ssDNA binding protein Ssb3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114:SF1">
        <property type="entry name" value="REPLICATION PROTEIN A 14 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15114">
        <property type="entry name" value="REPLICATION PROTEIN A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="122" mass="13177" checksum="4C7EC927D69A6CB3" modified="2018-10-10" version="1">MSLQTPRILPSHLHAFHSSSTSGPRSTHTVRILGTVTALRGDTASITCGNHGDVTLILKPDSHLQMGKLVEIVGKVADLEGGGVGIRVLGSMDWGNPADCDYKIYEQVVNATHRLKPIFYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7Z3</accession>
    <name>A0A317X7Z3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Exonuclease V, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_531668</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471495.1">
        <property type="nucleotide sequence ID" value="XM_025610950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7Z3"/>
    <dbReference type="GeneID" id="37113093"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="63085" checksum="8A915F683FA06FBF" modified="2018-10-10" version="1">MRIPRVAGCLGYWGERSLHGRFNRIGRVVAQEQRRFQATFVPRLRLVEHPDSTEGREKERERQAARHEERINDVNAELDTRSPVERFRRPPHKAFSVTDLISPAWCELQYWYTLTKFGRKRRTPAMKLGSTIHKTLEDEIYTTVPVDITTKEDALALRIWNIIQGLRMLREYGITRELEVWGLVDGELVTGVIDQLSYECPDSELEATAATYYADIEASRAILPEYQMSLSDYLLSATGGGRLLSDVYEQENAPKETEDPDMMASSQESNVPHIPRIYLTDVKTRGSGSAPTVKSTSFRPTLLQLQLYYHMLNRLATSDDVNIELLASRYNLDSNKPFTDAFIAEVGGLNDQFFDALVSQEFDPDYIPTPQDAIERRQSPHSSQSSSASPPPSSTSQDSTSILLTHNTLTSLWSLMKEQLRLTFLPPSDSLSVAPSIPSEFQPRMLEQYPTILSPLLTARYISSKPTAELQPRVLGSRSFLFDPTSMTSYITDQMHWWRGERDPRGVEVMEAWKCRICEFKEECSWRQEREWTYARRSRGRKAEEYDVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X809</accession>
    <name>A0A317X809_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_563780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471102.1">
        <property type="nucleotide sequence ID" value="XM_025614377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X809"/>
    <dbReference type="STRING" id="1450535.A0A317X809"/>
    <dbReference type="GeneID" id="37116520"/>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="604" mass="67924" checksum="C9BCAF121B045FA7" modified="2018-10-10" version="1">MACHRCNRKKIRCSKTVPCNHCVRLGLDCVFPGPGRAPRRKKRPLKAELVARLKSLEQELTELTGGSDRAEARRAGPGAADDGTLIVDGDSTQYLNHEALIGLGGQIKELQDIVASSGETTEAPDKGCAEPEQGNDTNYFVFGYSSLAYSLREYHPNTTHSLWLWQTYEQNVAPVVAIFHKLSLHRMITKASTNSEYLDRSSEAVVFAVYFAAATSLRPDDCLRYLGEEHSVVLQRYRFATQQALSRAGFLQSRCLPVLQATVLFLTCLRGAGDADFVWTMVAAVHRLAQGLGIHRDGTHFGLTPFETEMRRRLWWSIYLLDTQSSESYPTGNLITEGSYDTRLPLNINDSDIAPESIALPEEHVGFSEMTFCLIRCEMTVFVRRTTNTGSSVHEDLDLESRLYELEKIHARLQERYLRFCDVSIPIQWTTATVIRLALARLWLVTHLPQWQLNDLASVSPNQEQLFLTAVEVVEFAYLLETDPRTSKWSWLFESYMQWHAVTFILAEMCAQAPSPETDRARDYQRGGVMMKPISRLMEQAAAVHGRTATNVDSTLRLIADPEASKFTAPLIDGHETENATLSRSGEDMAPMEFLNEVMLGENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8F5</accession>
    <name>A0A317X8F5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_563358</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471580.1">
        <property type="nucleotide sequence ID" value="XM_025614354.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X8F5"/>
    <dbReference type="GeneID" id="37116497"/>
    <dbReference type="OrthoDB" id="160374at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1484" mass="166361" checksum="4E0C689DB1F0F17C" modified="2018-10-10" version="1">MPSVAERPRSSQEALLRLEKGTASPTTQLDEAAHIIGLDLALCASHPEINRTPHVQNNAAPKEEWVLRWLLKKLRAGKNYRVDSTSFLLLRQLIDLIPPKTLATTLKDQKFLAIFNQAIADLEEDVFAALKTGITDLLPSDSDSSYTLNDSPQRNGDYDKKGTKRKRAGDDEADAMDIDDQPRTPISCFLAFIRALDCLYSLIMLANRTPGVDEVASSHLRHALKGEPESNAVTLQKSFRLTAIITTQFSHARKTTDLQHLLYVFPAVLALWELRSSRRDDSDKGLSNECFAKHCFQSALRLQVCVRAIRLDTDERAHVLHVVERLIALHVVLPARGGFYERGGAGIDYSASEPDWTPVKPISDTLRPILCGVECPAETAEDASIQKKIMWKTAELLPEFFDIAVRSVPRDTFRRQTHEAPWLETLFVAIAELAFSTVKSQNTTTYLSEFVGILERLFRVVLVRNVQLSLHTLLTHASYTGLLKDGLSQVEWSLTALLVELGVDIFLPNSGLNDSTKLLKALLEKILSHWRSGKSQSDGSYETIKSDIVIPLLRGFVAARDLPTFMQFWYEQLMEVEEARSQDKSLKSFIVWEDDDVCNAYGDIMRSPLTHAHAAAQLQAATAEIRSEDGKISNTPGAYAQFVILESGFRNRDLSFEDKNEALSSIIETAASTLSTKQTLHWRWRLWRLARNLLENNVQSTDNDLGAAIMNLVDTGAVTIRRHHKDGLQKPWAPLECFEAYQFTLAAVKGALNNDQFKSLTSQITELVKSISSKDAVNSITSPWNGRIETLNTPETLALAYFLTLVRSPDIWARVEPETRRSLFGHILSLATAQYKSSSSALETVGPELRFLQAWASVVCHEYLLNAPAITSDLITVLASRIKEDDLNRKLFVESLQRIPAPLIMRRQRAVLLDLLQEVIVQGDSTPEVTVGMLSLMAKMAGMPKCAAAVTSNWEPIWTVAKAVTLQGNDVDLQIMKAFRNLHRAVMAKLLVSSDEERHKLFKKMYRKVASKASKLQTIDRDSMDCFYLRISLSQLWHHRKQLAGVFDETDLAACRQKLFDLVVVEVKSVKDQCKKQQLEETITLIKILDALEDFEDLAADHAEVEKFLSKIESYVEKSADSGPSLSRLIRRRVLAGRGSEKSITQPVIQCAEALPLQHMYSEEQRLFIRSTSARFQSMSVEELTRVIEDVRELGFVGENAEYHLLIAGLAIASLPPIEDKECHTAKELSWICTAVIESLSRNKSIEQFTLASECLDILLRDFTRCITQWNVDNLLASIAVCASKSGPRIDPEFAGTVYIRLCRLMGVLLGLHRQKLGGRFHLILPVIERLLDCLFARSKKRPRSLIYEKQLGQDPYWLAPLQATHAVHFTRLLTSLCDPTVSAVSRPAQSAGGFEGLTDQTKKAKRIAGQYLQYLIMKYTQSSLRGNLAPEVKAAILPGLYAVLDAMSRETMRAMNAGLDVSGRAVFKALYDDYVKFGKWNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8G2</accession>
    <name>A0A317X8G2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_582301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470638.1">
        <property type="nucleotide sequence ID" value="XM_025615469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8G2"/>
    <dbReference type="GeneID" id="37117612"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="267" mass="30345" checksum="EF344E64B359E7CF" modified="2018-10-10" version="1">MSYYPPQDSYYGGRPPYERPPYEGGPPPERPPYDRPPYDRPPYDRPPYESGPPPDRPPYDRPPYDRPPPERYNSGPPPSDRPPYDRPPYGDRSPYEGGERSFDSPPPRPPYASPPPSSRPPPVPPPPLPMDWVQEWDPNARRAYFVHIPSGRSEWILPADGSRDMGPPGPPPPQEGGYYSPDPEAAQAAAEEQKKKDRKNMLLGAAGGLAVGALGAAFITHEIDEHREEEREEEEREDAPPPMMYQRETIIEREEVPVYEPYPEDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8K4</accession>
    <name>A0A317X8K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_562657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471695.1">
        <property type="nucleotide sequence ID" value="XM_025614307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8K4"/>
    <dbReference type="STRING" id="1450535.A0A317X8K4"/>
    <dbReference type="GeneID" id="37116450"/>
    <dbReference type="OrthoDB" id="1918685at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18966">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="26"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="103"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="211"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="804"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="902"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="902"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="917"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="962" mass="108720" checksum="5CE3E31D50E22F59" modified="2018-10-10" version="1">MTESQDESDDDISISSTVASPQASEYEVEAILAECRFPDSMRYLVKWANYPECRSSWEPVEAFSTDETLDDWDRTKREIAAGTREAFDVAKWEQMMLKVEEERQERQRRRKAKRRRLGLLADNDTSQAMNDKSKTQSSSGSSRRIIPKPPLVMFGSGQKPGPAGPRATKTAQETDPKWFSHLSTRWKHEKAKFREPPPDITQLELVRPSEWPSRTALPVPKPSVSHTETDTSNDAARITANANSSPAMIPMSPRRDRSQPSRLNESGGDVIPNLPRRQPGPRAKLIAGRFCNPFEVLVNMYYGPDKKAIGLARLCGVNSLSAKNLIHTKDGPYIEVWFQHLCTLEDYRVLCHNAAQNRTFCTGWIEGFNDTEPNVYRMAQELDRGSLMAIFPGYETSNVLIAFPSNSPKFQSLGYIPRAHPDIFLKIIVRTPLESLASIERLHSRIGANDWRSDFHGPNSHGPDTPVKDSPRCKVLEDEPDAIEGKTDSSPMPLSPIRQEPESKQDPSLDRADAIKRETSNKPLELVSTEATGQIPTEAVDSAEDRQAPGEPMDIDQQQSSAPAAGEQQLISALATADLNAVFKNSFGASYEALVKVNSAEKVQMAEAFYLMFGSETLQQEFLTLQAWLNLHNPVIYSSHQEGDWEKFARTVGVGVVLFHESFVDFHTLPFFKNLISKPFNFWSVSLNKQLEYAERPSHFQRIFPHGGVILITEDFMLGEPDGTIIILAWFNDWIKKKFPGNWKIMFRPAVMDWLLKQPEPADESKHGIWLTMYRLILQSCTPSAYDTTSGEVLTGATDDYFESNAISPPNIPDYGSRTEKDNPDIPKGLTQDQRNTDHLVEFFAGWGLVNRHRYRRFIVLTRMKPLPRWESWQHIEIKYGAKDFMKTFRVDYRHYWSKLNSSSIKPSTTGESKAQPAPFTPHTPRAHAPAPVASGLGNETDGTRYARLPGSKLPSYPEPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X973</accession>
    <name>A0A317X973_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial chaperone BCS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_530937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471810.1">
        <property type="nucleotide sequence ID" value="XM_025610785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X973"/>
    <dbReference type="STRING" id="1450535.A0A317X973"/>
    <dbReference type="GeneID" id="37112928"/>
    <dbReference type="OrthoDB" id="9985428at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="1">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="302" mass="34259" checksum="F6BD35247063B0B9" modified="2018-10-10" version="1">MSPKLLSDYFRPVNRRSRSVTRTDRRTLLRSTAEETQALLPGILSVMPQAPPTAQYCPRTRYPALNPRFSPKLSTHVEVLFGDTFDIAIRLSNPSRQFRHSGTQNVCVLNMANEENPGGGWLNGAMAQEEALCYRSSLSLTLKRRYYPIGERDSIYSPTVIVFRESFTQGHGLMDLQKSELLPVVSVISVAALEQPEVDDATRPPRFKHSSDRELTKDKMRTILRISGYKKHRRIVLGALGCGAFANPNVEVAECWSEVLQEREFQGWWEKIVFAVLDDMSKVAQGDSNFDVFRERLHGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9D8</accession>
    <name>A0A317X9D8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_562871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471975.1">
        <property type="nucleotide sequence ID" value="XM_025614320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9D8"/>
    <dbReference type="STRING" id="1450535.A0A317X9D8"/>
    <dbReference type="GeneID" id="37116463"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="238" mass="26089" checksum="F04A1D2357ABE383" modified="2018-10-10" version="1">MASLGDYPLRQRRFAPLNPSKPTSSAPPLKGIVFDNKRLTQNRAALNIDKKVDILHHISRLPTPESQLEAANKIKAIERTAMRTQQPQPGLVQLMDFLEERGVKRALCTRNFEAPVLHLLNNHLPAHVFLPIITRETPGLMPKPDPAGILFIANEWGLDGGAGGLIMVGDSLDDMTAGHTAGAATVLLLNDHNAHLKDHAHTDLCIERLDELIDILDEGFVGHRGGEKVPTATDQETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9G4</accession>
    <name>A0A317X9G4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_222507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472004.1">
        <property type="nucleotide sequence ID" value="XM_025606228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9G4"/>
    <dbReference type="STRING" id="1450535.A0A317X9G4"/>
    <dbReference type="GeneID" id="37108371"/>
    <dbReference type="OrthoDB" id="4227594at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="157" mass="17526" checksum="84550E1E89D7CFFD" modified="2018-10-10" version="1">MSAKETAPARSSQRSEHSGSQEMKRKSSSSSSSRHTQQSGPKFFLKYMAEAQSDTNGPLLKINGAKASANVYNRERRSSSSHHSSSHRCNCCSLIGSWIFVLLVFLCLMITVFLFLFFPPYLFMYFPPDTFPLLVPSLYASAIIAYGLGHLWVLLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9K4</accession>
    <name>A0A317X9K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NUDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_460362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470011.1">
        <property type="nucleotide sequence ID" value="XM_025607880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9K4"/>
    <dbReference type="STRING" id="1450535.A0A317X9K4"/>
    <dbReference type="GeneID" id="37110023"/>
    <dbReference type="OrthoDB" id="5877028at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051642">
        <property type="term" value="P:centrosome localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033494">
        <property type="entry name" value="NUDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006964">
        <property type="entry name" value="NUDE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921:SF1">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10921">
        <property type="entry name" value="NUCLEAR DISTRIBUTION PROTEIN NUDE HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04880">
        <property type="entry name" value="NUDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUDE" evidence="8">
        <location>
            <begin position="134"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="278"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="320"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="611" mass="67301" checksum="2BCF7BB267DB3119" modified="2018-10-10" version="1">MPSADDSSSARPNGTSSRSDQLAYYKAQYEQLEAELAEFQASSRELEAELEKDIEASEKRERVLKEKLENLRYEVDEWKSKFKQSKSEANTAQNALQKEITTLRDTSRTLQLKLRDTEVANDDYERQARHTTSSLEDMEQKYNMAIERSVLLEEEVKAGEKEREALRIQNQRLRDELSEQKLDNEILQEKLRHEQYGGRRKKPTPLYRTQSSTQSSAPPAPEIFDRSPGTSTVSSPLFVTTPMKSSLMAVTVPPPSPPMSETSSSLMTNMMTNMRKSVHTSSGFPHKKAAGSESMMGSRSMYDSRPSKSSRSRVTANAHSSARSVSTVASRTTLPTSMPMTLPSFSNSPTFNNDTPQSKLPKSGSLYQIRGLIGKMQKLEERVQSAKSKLPPPSDSPSRTSSRSGSISVNGGSPVPSTITMRRNSRKRLSGSSFSSSVRDNDGTSSSVSNNRPSFGTRNGGDSRPSSRTSYSSSFSQSTHPSIAPSTRPESRQSRTKTPLGHYSTNPTTESRRPRSSLSNPSGQNGPLNGMSNIDEDEDQDLAFRMSVRAKISEARETRFPSFSTPTTGLKKRTPSGISAIPAPRTLRTSTGGTKATPDAKSNHGDLGETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA49</accession>
    <name>A0A317XA49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Peroxisome biosynthesis protein Peroxin-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_481996</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472237.1">
        <property type="nucleotide sequence ID" value="XM_025608875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA49"/>
    <dbReference type="STRING" id="1450535.A0A317XA49"/>
    <dbReference type="GeneID" id="37111018"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF4">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="84"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="407"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY95476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="485" mass="54334" checksum="9FB79DA8A56D6AB7" modified="2018-10-10" version="1">MSSTNFAAAQERVLERRRLREAEARARLAEQQRASPLNHPTLQRLPYPLNKLPQSAFSLWNTIRGREGIRPAYRVGQVDAELLDEELLGLLKGQVGDALKYFGPQMREDWSHEIQFTLRAILFKLSIWDHNSSYGAALQNLKYIDSRSKGPVYSAPTKWQKSLYGLLTVGGRYAWGKWESWLINQESGYEEPSQEVRMLARLTDLVSATHSIAAFVSFLVFLVNGRYRTLADRILRMRLLPPSAQASREVSFEYLNRQLVWHAITEFLLFLLPLVGISRWRRWLSRLWRKTLSTLKAGSEDDEQTGKQGELAFLPERTCAICYKDNNPTSTTEGEAIAASASSGGIIGSAQTDITNPYETIPCGCMYCFVCIVQKLEGEEGEGWVCLRCGEIVKKCKPWNGDVLEETRPQSSSGKMVGFAVDGSAGPDDSTVDEQEAEGHTGKKSPLQELASDEALHHSSQWSTIEKDSVEEVYDGEVEAAGSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA75</accession>
    <name>A0A317XA75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_127135</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472247.1">
        <property type="nucleotide sequence ID" value="XM_025605620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA75"/>
    <dbReference type="GeneID" id="37107763"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016430795" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="35"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="246" mass="24736" checksum="7673803AB40E177A" modified="2018-10-10" version="1">MRFFTTALVSALAALASAYTTPNYSEDPSGNAIYTPSLNEIVAAGSPFEITWDPTTTGTVSLVLLRGPSTDCVPIQTIVEDIDNTGKYSWTPSTTLEPDTSRYGILLVVEGTGQYQYSTQFGISNAYYSSSSSVAAATTTTAAAVSTVSSATQVVVTQATTVSAETVTADVKPTVTSVPVIGGTKPTSLVAAPSGLSSSLVASSAAASGTPAASSSSVTPLYTGAADRNAISFGAVAAGVVAVLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAG0</accession>
    <name>A0A317XAG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_532454</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470271.1">
        <property type="nucleotide sequence ID" value="XM_025611120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAG0"/>
    <dbReference type="STRING" id="1450535.A0A317XAG0"/>
    <dbReference type="GeneID" id="37113263"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="546" mass="60918" checksum="B7DF331B1E1B4A89" modified="2018-10-10" version="1">MSKTFTKDDVASHSKPDNLWVIIDEDVYDLTGFQDEHPGGKKILQRVAGKDASKQFWKYHNEGILKKYKGKLQIGSLDSKKAAASEPAASPAPAKTQTSKPVAAPVDVASAKSSETQDPYGDLVPFADPSWYQGYHSPYFNQTHSALRDEVRQWVDSEIEPHVTEWDESKKVPDHIYKQMGERGYLAGLLGMKKYPVDYTAHRVQSVAPENWDLFHEMLLTDELSRVGSGGLVWNLIGGFGIGCPPLVKFGKKPLVERILPAILAGDKRICLAITEPDAGSDVANLTCEAKLSPDGKHYIVNGEKKWITNGIWSDYFTTAVRTGGPGMNGVSVLLIERDMGGVSTRRMDCQGVWSSGTTYITFEDVKVPVENLIGKENQGFKVIMTNFNHERIGIVIQCVRFSRVCYEESMKYAHKRRTFGKKLIDHPVIRMKLAHMARQIEATYNWLENIIFQCQSMDETEAMLKLGGAIAGLKAQSTTTFEFCAREASQIFGGLSYSRGGQGGKIERLYRDVRAYAIPGGSEEIMLDLSMRQSLRVHQMFGLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAN8</accession>
    <name>A0A317XAN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcium channel YVC1-like C-terminal transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_281822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471453.1">
        <property type="nucleotide sequence ID" value="XM_025606628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAN8"/>
    <dbReference type="STRING" id="1450535.A0A317XAN8"/>
    <dbReference type="GeneID" id="37108771"/>
    <dbReference type="OrthoDB" id="310870at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="389"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="3">
        <location>
            <begin position="294"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="597"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="696" mass="78500" checksum="82AA9128B547B64B" modified="2018-10-10" version="1">MASLRLESSTSSIAPAEQLPFEVPIIDDNELLVDVVRKLHNYMLVAINDVACTFEELRFSPHGQSLRLLLYSLAENSHNPCIISALMILKWQFSNDAENDWGLNESRGYACEYVAWQFLCHIDQRETIEYLLEELKVPIQSGINISQAERGTSGFASAAGEPFTQEGERTPLLLSSSSSLYRFFGGKRRTGSSLDIDEPGSNVSASDAYELERLSRFFGLNALEIATIAHAKRFLSQKVVQKVIDNIWNGEIVFWDSLSVHSKKKPQFFNKRTADPYSRLRVPVYRKAFEAAFFVSFLFLYYAVLVERKPTGIGLFETMMYIWIAAFAYDEVSGMADAGMLFYQMDFWSAWNMGIIGTGLAFVITRIIGLAKHSDYITDVSFDILSLEALFLVPRICSLVSLNSYFGSLIPVLKEMTKAFFRFIPVVVVLYLGFLTTFTMLARDRLSLRQMSWILVKVFFGSNVLGFDIAHDISPIFGYGLMLIFVSMTNLLLISSLVSLMSMSLEGVMAHAREEYLFQLSIYVLESSNSRRLTYFMPPLNLIPLLCIRPMRLFLPAEHIRRVRIVLLRATHLPFVALIWAYESSRRYVSRRNSQFPPTATTTATGSSRPTSAIQMGFPLSTHHAPLHASALDGRSLGSSRPRERSNPGQQPAARGPSSGQTGRGDTADMIDEVERLRTQVERVAARMTFHQRGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAW4</accession>
    <name>A0A317XAW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_572256</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471468.1">
        <property type="nucleotide sequence ID" value="XM_025614912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAW4"/>
    <dbReference type="STRING" id="1450535.A0A317XAW4"/>
    <dbReference type="GeneID" id="37117055"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="14">
        <location>
            <begin position="453"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="415"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="464"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY94707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="692" mass="77030" checksum="455C5F45EBA532B9" modified="2018-10-10" version="1">MESRGLTLRSKSRRPRPQISAPQPISGPLPTTNGSKGVAAPPGQITASPSSTSLERGPPKDATSDLVKRRYSTRFNQIPDFDASAPPVPGLPKAPATYGGLSPPETSRRPSTESSAPPKVDLNALRDPSLPVDKYVANLLANASEEEIEEYQKSLRKVKNRTSTDLQQNVYQNRTQFIKISKEAEKLKGEMRTLRTLMAELTTALGQTTVGNTPNPMSPTIDEYMPKRNANRSSVANLESMWNVQLQTLWKTVEGSQKFLPVAPGRHIVMETGHWVELDSATWKPRRPVHIVLLNDHLLIAAKKRKRVDQSSHRGPVPTKLVAEECWPLQDVDMIDLGANLSAGAAREEAEDRGIANAINVRVGGKPFTYRHDKRDSSAKGDLLATFRKTVEDLRRTLRSETEAASKSTESFGYLGVRRPSYSPKPDQYDGGESSRDKPEVRIDVDGKQQNLRWVDGQVDELDIDIALQRFEEAVANIERLRKLAKGLKGNAVAQDVINAKVDERAASLAEVLLRSLVDTHSFPVATKNRVSWLTRLGFEYQAREAYLKSRTEVITKRIRACVFEGDLPLYIFQISYVYFTLIKNTISIYQQCFPPVMSSASIRWAKHHLDGFNALLTRQLSSVQRGTTVWQKCIDIVREHANLLAEVGVDFTDLVAKDLETGEEFTERPQMTRSESLISGLAETAAAAMII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAW7</accession>
    <name>A0A317XAW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">SnRNP assembly factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_511431</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470421.1">
        <property type="nucleotide sequence ID" value="XM_025609768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAW7"/>
    <dbReference type="STRING" id="1450535.A0A317XAW7"/>
    <dbReference type="GeneID" id="37111911"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="13">
        <location>
            <begin position="109"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="231"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY93660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="617" mass="69004" checksum="CA562659571B6F9B" modified="2018-10-10" version="1">MMSKRQAELSLEDDLTAGSPASKRARVEDDNLPEDDPRRGALPIRGATGQELEQDERSGQNVLAAADQEREELKEAAQDKGSDSSDEAGDDDKPVIAAPKRQSAPMEGYGDLYLDTINREILDFDFEKQCSVSLSNINVYACLVCGKYFQGRGPKSHAYYHALEVGHHVFVNMGTKKVYVLPEGYEVRNQSLDDIKYVVDPYYNKEEVAKLDKEVHDAFDLAGSRYRPGFVGMNNIKANDYLNVVVQLLAHVFPIRNYFLLHDFPQPGTPQLALRFSTLVRKLWNPKAFRSHVSPHELLQEIALRSSKRFTLTQQSDPVDFLSWFLNNLHLSLGGSKKPSKTPTSVIHAAFQGHLRIESQAITAHSDTQNARLVFTESGSINSQTTPFLILTLDLPPTPLFQSANRESIIPQVPLTTLLNKYNGITASEKLAHRVRHRLLHPLPPYLLFHIKRFSKNRFVSERNPTIVTFPSPRSLDMSPYVEPNPNIWPPGEPILYDLVANIILDPTVAAPGAHEEAAADKGVNAASGKASSGAGAASEKVSWLVQLHDKAMSAENSRLQKDHTGEQRGPEWLEIQDLFVKRAESETLFTKEGYLMVWERRKVPGMTNRKGKNPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBG1</accession>
    <name>A0A317XBG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dihydroxyacetone kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_582680</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471059.1">
        <property type="nucleotide sequence ID" value="XM_025615490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBG1"/>
    <dbReference type="STRING" id="1450535.A0A317XBG1"/>
    <dbReference type="GeneID" id="37117633"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000002">
        <property type="entry name" value="Dihydroxyacetone kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="14">
        <location>
            <begin position="14"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="13">
        <location>
            <begin position="389"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY94298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="594" mass="63270" checksum="90DFE1115CDF1622" modified="2018-10-10" version="1">MKSDLLHTKHFFSDPTHLVQTALHSLTLTNPSLAYDPENKIIFRRPDAASQSKVAIISGGGSGHEPAFAGLVGKGFLDASAAGTIFASPSAEQIRKAIMDCVDNEKGVLVIPMNYTGDVLNFGMATEKARAAGVKSEFFAINDDVGVGKKKGGKVGRRGIAGGILILKIVSALAEAGGSLEDVYRTAQLANKNLVSVGSSLEHVHVPGRALPTDTIPDGEVEVGMGIHNEPGSHRVKFTLVDLVSTMLLQLLDHNDPDRAWVTRKPEDDFVLLINNLGGVSTLELAGITDEVHRQLERDYNVKPIRVIQGTFLTSLNGLGFSISLLKLVDTGLGSGKSFLELLDSPAEAVGWSAPIRTETWKHRTDAPVELKRTKMPEDQPSNVTLDVSVLKKVLGTALTRVIAAEPEVTRYDTIVGDGDCGVGLKRGAEAVLRLLEDPSSKITDDVVNAVNRIVSVVENTMDGTSGAIYAIFLNALAHGLREQDRGTTTPATVEVWAAALSYSLSALSRYTPAQPGDRTLLDALVPFCTQLQKAKDVHVAARAAQQGTDSTKNMKASLGRSVYVGGEEEWVGKVPDPGAHGLSVFLNGLSEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBJ8</accession>
    <name>A0A317XBJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_455749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472684.1">
        <property type="nucleotide sequence ID" value="XM_025607674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBJ8"/>
    <dbReference type="STRING" id="1450535.A0A317XBJ8"/>
    <dbReference type="GeneID" id="37109817"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF48">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="37"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="485" mass="54224" checksum="CE4678AF30841855" modified="2018-10-10" version="1">MNNVEQGLVATDQCGTPPVDINEKAESRLRRKINFYVLPPVALMYLFCFIDRANIGNAKLAGLEHDLNLHGNDYNAILSIFYIAYIIFEIPSTIACKLIGPGWFLPTITVLFGICSLCTSFVHSIHTASAVRFLLGIFEAGMMPGIAYYLSRWYRQRELAFYLSIYVVTAPLAGAFGGLLASAILTLDHLGTLHSWRMIFAIEGLLTITLGLLTFFILTDRPKTARWLSPEQKHLAITRLMSERVNTTELLDKLDKPKILRGILSPITLTTSLIFLLNNITVSGLAFFAPTIVKSIYPNTTIVAQQLHTVPPYLVGAFFTILFPYLSFRFNHRLIFFLLAPPLMITGYIMFLTTNSPHIRYGATFFISSATFTFGALCNAHVSNNVVSDTARSAAIGVNVMFGNIGGLISTWSFLPSDAPMYRVGNGLNLTTSVLTFLLAAGMWVWMERDNRRRDQVDVERALGGLNMSEVQDLDWRNPGFRWRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBL6</accession>
    <name>A0A317XBL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_507868</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 7"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471768.1">
        <property type="nucleotide sequence ID" value="XM_025609639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBL6"/>
    <dbReference type="STRING" id="1450535.A0A317XBL6"/>
    <dbReference type="GeneID" id="37111782"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF57">
        <property type="entry name" value="DEHYDROGENASE UGD1, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016233970" description="UDP-glucose 6-dehydrogenase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="384"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY95007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="515" mass="56747" checksum="09708FA3CEE9BA9B" modified="2018-10-10" version="1">MMPFIPLLFVLASLTLLFSRRKHKAIEGAEPRVVVKGHTYSDSVEETELQPLPRKKVENVRNACIIGAGHVGALTAAVLASQNPHVQFCVVDNDAALIAAWNSDRLPVFEPGLDELLVQPRKRKLANLTFSTSVHAGVVAADLIFLCAETSSTITIDEKERLDLSQLEYAIRAIAQVSTGHKIIVQKSTAPCGVVQRMKKILRKSASPSASFDVLSNPDFLVPGTALHDLLYPPRVIIGHIFSEDMSPEALKALKQLYIPWIPEERIITMDAWSSELGKIAANAFLAQQISSLHSLSAICESTNANINHITQTLGLPQRVGFGFGSSHLQTEVLCLVYLARELGLQQVAEYWRAVLRMNDSHNRRIAKRVLSQLSGDLTEQKIAILGFTPKENNSQYSVALGLIRDLTSNGVQVSIHDPFIPADQLENTLRVSNASLETVTVAESVEAACAGCSAVVLHTDWETFGHEKVRWQGIASQMQSPKVFLDPYGVFDQFKMQQWGFKMLQVGVRQAETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBP5</accession>
    <name>A0A317XBP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_530685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family. Isoflavone reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472700.1">
        <property type="nucleotide sequence ID" value="XM_025610725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBP5"/>
    <dbReference type="STRING" id="1450535.A0A317XBP5"/>
    <dbReference type="GeneID" id="37112868"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="259" mass="28853" checksum="6B8AA284E2399A6A" modified="2018-10-10" version="1">MTITVGVAGITGKFARLVVKNLFASPDVHIRGLCRNPSKLPEQIRTSPRVTIIKGEADNLETLQTFVHGCDVVVCCYLGDNTFMTDAQKLLVDACEAESVPRYVASDYCLDFTKLEYGQHPAKDPMKAVKAHLETKQTVRGVHVLIGAFMETFWSGYFGIWHPDDFKLSYYGNGDEVWESTTYDTAAEYVAAVTMDPSAVGLQHFLGDRKSIRQIADEFAAVYGKKPRLERLGSLQDLYDTMQATCQKDPSNIFAYLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC04</accession>
    <name>A0A317XC04_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydantoinase/oxoprolinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_570501</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472887.1">
        <property type="nucleotide sequence ID" value="XM_025614818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC04"/>
    <dbReference type="GeneID" id="37116961"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="1">
        <location>
            <begin position="206"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="3">
        <location>
            <begin position="605"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="4">
        <location>
            <begin position="782"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1003" mass="106176" checksum="E655AA6020458252" modified="2018-10-10" version="1">MGFRIGVDVGGTNTDAAILDTTPALIDQPSRGVCASSKTPTTADVTSGIYTAIVDVLAKAQVPRHDVRSVAIGTTHFVNAVVEADPRRLSRVAVIRLCGPYTRAIPPFFDFPPHLRDIVGGPVYYLDGGLEIDGREISPISPKQIEDTVREIETAGITTVAIVGVFSPLDHQGVHEETCKKMILQQNPGLSVVCSADIGSVGLLERENATILNASILALAKKTIRAFCQAMQDLQLDCPLYLTQNDGTLTSAATAAERPIQTFASGPTNSLTGAAYLAGLDRRSINADTQVLVMDIGGTTSDVCALLPSGFPRKAPNFVEVGGVRTAFPIPEVLSVGLGGGSRIRVDAADSVTVGPDSVGYRLTKDALVFGGDVMTTTDIVVASGKADLGDASKVQHIPAVVLAKARASMKKILERAIDDMKVSDQPVTLLLVGGGSIVCIDALEGVAECILPPHHDSANAVGAAIAKVSGEVDIIEILEGRDERAVVEAAKQQAVEAAIARGADKDDVTVVEVDKIPLQYVTNKAIRLVVKAVGKLAAPVAGTPTDGHPVSWISTVDEPPSEPPAATVASAPPSLLSTKHIASLDIETYVPEVTDNVWYLSAVDLEFIATGTGVLGTGGGGPSYLQYLQCLDWLQGSAKGRMRVISADSVSDTDVCVFGSWYGAPSVYGERIPAKTELTTAIDHAVRLSGHSHFEVIIADEIGGGNGMSTFPTSAYYDIPVLDGDLMGRAYPSMEHGMIPPLDAARTDVVVGTPYVYGHPITPCVIADAKGNVGVVLEAESNRRVEELLRSQCVNLGISTAVAAVPLTCDIVKKYCIPNTVSQAWYLGRAIHRARRSKTDVVKAIFETTPGKLLYSGKIIDVKRDVSRGYTMGQCTIAPLSGEEREESDCNAAETRHLMIPFQNEFLYAAYIDPTNPEASNEVICTVPDLISVLGQDGEAIGSQELRYGLRVNVIGIAAHPLWTGDERGLRVGGPKGFGLDMEWTSLGPYQASRSVIAEFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCZ4</accession>
    <name>A0A317XCZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Multidrug resistance-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_621271</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471579.1">
        <property type="nucleotide sequence ID" value="XM_025616990.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XCZ4"/>
    <dbReference type="GeneID" id="37119133"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="934"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1114"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="278"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="609"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="899"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1208"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY94818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1447" mass="159745" checksum="DF675F3EE641EF26" modified="2018-10-10" version="1">MSSGCSLEADNVFGPVVSHACRDGFDFTLLFEQSILGLLHALAFLLASPLRVRHLAKRDVRTRSNTTRMAKLVIALGFAALQLTLLVCWARSVTPRTKVSVPFSTINLVVAMEIMVLSWMEDARSARPSSLLNLYLLLTLLFDIAQARTLWLARSGVHIPILFTTSVAAKTTMLLLESLEKREYLTGKYQDLPPESTSGIVNRTFMWWLNRLFLAGFRSLLTVGDLFILDKRLASVGLAKKAQRAWTQRRSPERRFEFPWQMCRALWWPLVSAVFPRLCLIGFTFAQPFLITSTLDWLNDPHSAENKGYGLIGATVLIYLGLAIFTLHYDHKLYRFLTMFRGAASSLIYEHALRIPDGELEDRSATITLMTTDIDRITACLANLNECWARAIEVVIGITLLALRLGWVSLMPVIIVIVSSLGSTQISKNIGNRQKVWVDAVQQRIAITSSMLAEIQIVRRMGLSKTFTKLIQDQRVQETHRMAGYRRSIVWQNMIQNLPWALAPALTFVVYASQGQALDITNAFSSLSVITLLTIPASKLLSAIPSTAAAVGCFDRVQAFLLTPIEQYNRRIVPDAVKNPLVHTHLRSDSLVSLPSRNSDSANPSSPVIVMDSVSIRPLIKAKPVLQNITFQVPQGALVMVQGPVGSGKSTLLRTILGQAVCESGVVTVAIPRPAYCAQTPWLSDSTIRDAICGGAQTGPAKGQPIDREWYEAVLHACALAPDLMLLPKGDATQISGGSGPTLSGGQMHRVALARAVYARRKLVLLDDVFSALDRKTKAVIMERLFGGNGLLRRLKSTVILVIHETEYLSYADQVLVLSDGNLRQEEAHERKLRQPSSFPTAANERDNEGEYKEPTIKDIAARLSQRNQINDLKRATGDFAVYKYYLRYIGWSKITTFLIFVIVHVVCSTYSQIWLKRWANRGGGQKPLYVTVYLLLAIFNTVGIGGYVWAILVLISPATARRLHYVVLKTVMRASPRFLATTDSGTILNRFSQDMTLIESQLPVGVLIAVTNLFSAVASAALIATGSSYMAITVPFLIIAVLVLQHFYLRTSRQMRLLDLESKSPLYSHFLDTVKGLATIQAFGWEDDFRTKNLRLLDNSQRPHYLLYCIQRWLTLALDLIAAAEAVILVSLAVFLRHSTNVGLLGVSLNNVLTFNSSLSSLISGWTQLEISLGSISRVKDFEMEVAREEEYQKMEPPRDWPDQGAIEFSGVTAQYSPDAIALKGVSFKAYPGQKIGICGRTGSGKSSLLSTLLGMLDITSGSVVIDNIDLAAIPRETVREQVITIPQDPLLLVGCTVRLNVDPAGQLSDADLIAALDRVGLWTDVLEARGGLDAEIKDALSLSRGQQQLLELARAMLKLHVSHSKIVLLDEATSGVDVETDARMQDILRQAPFNSCTILTVAHRVSTIRDSDLVIVLDKGRVVEMGKPGVLAGQNGSNFASLLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD10</accession>
    <name>A0A317XD10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_8949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473170.1">
        <property type="nucleotide sequence ID" value="XM_025617728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD10"/>
    <dbReference type="STRING" id="1450535.A0A317XD10"/>
    <dbReference type="GeneID" id="37119871"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23811">
        <property type="entry name" value="UBCc_ScCDC34-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000063">
        <property type="entry name" value="CDC34p Ubiquitin-conjugating enzyme (E2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="152"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY96409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="226" mass="25510" checksum="BC7C56DDEAED7674" modified="2018-10-10" version="1">MAERILMNEYKALSQEPWVNIEINEQNILHWTIGLIVLNPDSLYYGGYFKAIMKFPSNYPYSPPEFRFVHPLFHPNIYKDGKLCISILHAPGEDEMSGELASERWSPAQRVESVLISILSLLDDAEISSPANVDASVMLRKDPDQYKSIVQQHVESSKDDIPEGFIMPTHESTTSTSKPVEKDDSDFWAESDVDDDVFGGSDSDEDLDVDDDDDQDTGSEDEHMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD74</accession>
    <name>A0A317XD74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_541778</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472423.1">
        <property type="nucleotide sequence ID" value="XM_025613058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD74"/>
    <dbReference type="STRING" id="1450535.A0A317XD74"/>
    <dbReference type="GeneID" id="37115201"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1300.10:FF:000014">
        <property type="entry name" value="Phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="8">
        <location>
            <begin position="270"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="636"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="784"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="662"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="784"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="823"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="871"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="914"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="938"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="950"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="356"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1001" mass="110281" checksum="C22A725AD089885F" modified="2018-10-10" version="1">MDRFDCSAIYIDHRVRSERWVYQGTPETPAGATSDSGVIEEPESLSSDVQVLLGVCKRIYLCQAGTSIATKLAELSDGAHTRCTPIFVFFDVDIHGEEAALHRRRASRGSWADVSPPSPASLRRGFTFTSQWEGAYDLKLLSGLSADIQVQDCPNVIIPVAVLRSPFADPTSASPVEQPRIPSLPEPQHISKCLDAGAVDVLVTPLDSCRAQALVVQAYRTRKTALREQSRFLSRKKLRKHSWVGVHDEQPYAYLREAMVSKLMRGICNPEEVIEEFQDRELDVRPDRADFVREHIGKWSFTAHEFSDDELVLAAFEMLQHALTDPALEQWQLLPGELRTFLLACRASYNSFVLYHNFRHAIDVLQSVFCFLLHIGALPSYGSAGPTIDTKCPIASLLTPFDTLTLLISAIGHDVGHPGVNNFFLVKLNAPLAQLYNDNSVLEAFHCAAFSQILRRYWPTAFRDRQLRKLLISSILATDMGVHQKFMERLGSLQEKFHENKRTTDGWKPQDLDLYKTLLCGLLIKCADISNVARPWEVAEKWTQILQEEFANQGEMEKEVGMETALFGGPPELGNVYKLATSQIGFMSIFALPLFEGVSDILPDLKFTVEHIRSNQSKWHFLADMEKNRQTLQADLRPDDLVSPRTQSPIPSLKGLHAPLAINSSNTPLRSSFPTSEPASRQSTPDDYFGAAATPLGSDEAPSDYNENTISPVVSPDTPGPSMDITGYQLPPEEAVSRRSSGVIPEGDTDSPSARPSDALDDSSDANRTPSDPTALAAALLANGSTAGNGDTSGRSSGRNSSVEGRPSSSRYGLPSGRRHHANTASSGRTSGPSNSQRNSCTRTHSVSTYSNNMTPISPSTNATSFLSVDSDEKNLPRESISRSDQGEWDRANNIRPATSNHEPAIAAYPSARRNSDPHSYDAGKHRMAVSPVGTGTGSSAQSTTTTGSMKHEGHGPRWDEHGPGEHAPPRKLPKRRSRLRLAFWKRRTHHSHQHELSGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDE0</accession>
    <name>A0A317XDE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_571573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471679.1">
        <property type="nucleotide sequence ID" value="XM_025614877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDE0"/>
    <dbReference type="STRING" id="1450535.A0A317XDE0"/>
    <dbReference type="GeneID" id="37117020"/>
    <dbReference type="OrthoDB" id="4828117at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="270" mass="29532" checksum="0D024C9E524DEC92" modified="2018-10-10" version="1">MVNWKLPEPTDRLIAALIAAHPALKIDYQTMVIYFGQGANYDTMHGRLRRCHILAEELQKETRERGGITDLPRARKSTTGTGFSTPRTPRGPRNGIQKASSSSSSRGKVFPRPLDLVTPTRSGPAARNGGSAIEAITIDDDFMELESTIRPAVKTDSRTVFPIVDTSSEDDIEIIDHPASFRIGKVEQPPQPSNTFFSYSGINNENGYGLKPERTESVLLDTTTNEADRAKTVAPIPPPSNLTTDPFNTSMGGFFVNSDYDIDDIYGGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDS1</accession>
    <name>A0A317XDS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UMTA methyltransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_570953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473455.1">
        <property type="nucleotide sequence ID" value="XM_025614848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDS1"/>
    <dbReference type="STRING" id="1450535.A0A317XDS1"/>
    <dbReference type="GeneID" id="37116991"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF96">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="1">
        <location>
            <begin position="70"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="298" mass="32903" checksum="D3F623CF731719FB" modified="2018-10-10" version="1">MGDNTTPTPPTETGTGTATFHLASSESYALQHNHLAACRLNLQHYLWREVFRFNIHPSIPTTTTPLAIADIACGTSLWLIDTARDLPHAHLDGYDIDLTQSPPPQWLPKNISLHEWDALTPAPAHLHGKYDIIHVRLVVLFLTGIDPTVFIRNIYTMLKPGGWVQWDELDCANISVKTTTPGVSVPALEELKVACSADGRHDWSIELAEILANHGFEDTKLQFFDEKDELVRAFGDQHLLTMGEFANKLAGRGEKLAAGRFNLLVERAYGEMVERGAALAIPRVVALGRRPLSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE43</accession>
    <name>A0A317XE43_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_481840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473534.1">
        <property type="nucleotide sequence ID" value="XM_025608870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE43"/>
    <dbReference type="STRING" id="1450535.A0A317XE43"/>
    <dbReference type="GeneID" id="37111013"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000036">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000092">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016296790" description="non-reducing end alpha-L-arabinofuranosidase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="10">
        <location>
            <begin position="448"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY96773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="632" mass="68600" checksum="8069A6C4DB863606" modified="2018-10-10" version="1">MVAFSTLSGISALPLLLSLVQHVHGISLEVSTQGGNSSSSLLYGFMFEDINHSGDGGIYGQMLQNPGLQGTTPNLTAWAAVGDATIAIDGDNPLTSAIPSTIKLKVSKDATGAVGLTNEGYWGIPVDGSEFQSSFWIKGDYSGNITIRLVGNSTGTEYGSTTFTHTSTADSFTEATAKFPTTKAPDGNVLYELTVDGSVAAGSPLNFGYLTLFGETYKSRENGLKPQIANVLADVKGSFLRFPGGNNIEGYSPENRWKWNETIGPLEDRPGREGTWTYYNTDGLGLAEYFYWCEDLGLAPVLGVWDGFALDSRGGTPLTGDALTPYVDDVLNELEYILGDTSTTYGAMRAANGQEEPWKLTMVEIGNEDHLGGGCDTYPERFTQFYDAIHAAYPDLILIASTSETDCLPDSMPEGSWVDYHDYNTADGLVDQFNYFDNLNRSVPYFIGEYSRWEIDWPNMQGSVAEAVFMIGFERNSDLVKMAAYAPLLQLVNSTQWVPDLIGFTQSPDMTFLSTSYYVQEMFSTHRGDTIKEVTSDSDFGPVYWVASSAGDAYYVKLANYGSESQDLTVSIPGTTTGKLTILADSDLEAYDSDTQTLVIPSESTVQASNGTFTFSLPAWAVAVLAVNRVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XER3</accession>
    <name>A0A317XER3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_529688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473063.1">
        <property type="nucleotide sequence ID" value="XM_025610503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XER3"/>
    <dbReference type="STRING" id="1450535.A0A317XER3"/>
    <dbReference type="GeneID" id="37112646"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF3">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="322"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="995" mass="110290" checksum="8F12BB7EF9493EAA" modified="2018-10-10" version="1">MAIVGLSEGEVQKRKNEEEVQAEPKRLKMMGGFVDEGDEDEWDAFEEAQGKKIGETQPKQKILGGFVDEPDDDEWDAFENAQGQNEAQTEPKRQKIMGGFLDEADDDEWNAFEDAQLRSDFQVQEEIIQLPPVELPEIPRPSQTVEPDLTPKASVPYLEPTPTTIIPFVPSRGPFRSIPIKTCSGKTHYVPLKKAATRVSYERLVAGRSTTAPGKAQKSYYGIDIHKLLDEAAKEAETQSPTRPAPVQSIEAPVDDRKAKLAAAMWTEKYRARKFTELIGDERTHRAVLRWLKAWEPIVFPNIARSKPKKPVNGKEDEERTHRKVLLLCGPPGLGKTTMAHVCARQAGYEVLEINASDDRSRDVVKGRIRDALATENVKGMNVEVGEEKVRKAGRPVCVVVDEVDGVTSGSGGSGEGGFMKALIDLVLLDQKNSAASSEQNKGKKKKGDNFRFLRPLIMVCNDVYHPSLRPLRAASVAEIIHVRQAPLENVVSRMKRIFTVEGIPSDNDGVRRLCEASWGLARRKQGGVKSSGTAEGDIRSVLVAAEWVAHKLRNECPSTLRLTRSWLEQKVLSANTGGSAFFKGLNRGGVRDLVERVFTEGAGFADAPVGVDSFRDPFANSDEKVPVGVADLRKRHAIGRLREMVDASGEHDRCVAECFASYPLQTFQDDTFLSKPNAAYEWLHFHDTMSSKVYTAQDWELSAYLSQSVVAFHHLFASAQGKAKAQDPVDDDEEEHPFSGPRADFAAYEAQKQNRAILTEFQSAFSAPLSRLFRSTDSLVIDLIPNLIRMLSPDVKPVVVRGSGEQRSVASVRKESERALVQSAVRVMAGLGVRFEKVRIENAGAHNGWAYRMEPPLDTLITFSKPNPTSTSTAAPVRYAIRQVLDQEYRKENIRKHSHTEPLSKTSSKKSSQKTGDDPTGMKKTPRDGPNVKRDFFGRILKEPTPQPDENGDAAAAAQNESLKAGRRVWVTYHDGFSNAVRKPISLGELLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEU2</accession>
    <name>A0A317XEU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_2571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472968.1">
        <property type="nucleotide sequence ID" value="XM_025606467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEU2"/>
    <dbReference type="STRING" id="1450535.A0A317XEU2"/>
    <dbReference type="GeneID" id="37108610"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="319"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="601" mass="68648" checksum="C43DAD8F0F8CEB03" modified="2018-10-10" version="1">MPNPIREDIAVRDDTSFPYIFEQNVTIALKDESGLVRCNIYRPKELEKAPVLVTYGPYGKDIPYSDFHPKSFSEVNQEHHSDHSAWETPDPGFWTKHGYAIVRADERGTGQSRGKLDTMSRETSEAFFDVVEWVAEQPWSTGKVGLLGISYYAGSQWRVSARQPKGLSCIIPWEGMSDYYRDRCRHGGILSNAFIKFWWDRQVVSNQYGLPGRAARNWGPDTIEGDLSEEELQANRQDQTVDNVNNNFRDDEYYASKEYTMSDIQVPLLSVANWGGILLHLRGNVEGWTQAGSELKYLRFITGRHDLPFYYNEEVEIQRSFLDAFLKGDDRVGWSTGTAPKVDLVLRRGDVGFNNAEAEKGFPRRIENEWPIARTQYTRYYLTSKQELVTAAQQERPVKITYRALGNMQNSQLVQFTTPPFEQETEITGHIVAHLNVSMSSEPGSPTPKDIDLFLTLRYISPEGKEVFYTGTAGDPVPLCKGWQRVSLRKTNPEHPRHRDWLPYRNYYSTDVLPVVPGEVYPVDVEVWPTNVVVEKGGKIILEVSSGDTQGCGIFQHNSPEDRSPERFQGLNHINFGHGDNYVTLPVIPSRGWLEELRMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEW1</accession>
    <name>A0A317XEW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Signal recognition particle subunit SRP68</fullName>
            <shortName evidence="10">SRP68</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_530246</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472279.1">
        <property type="nucleotide sequence ID" value="XM_025610641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEW1"/>
    <dbReference type="STRING" id="1450535.A0A317XEW1"/>
    <dbReference type="GeneID" id="37112784"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3450.40:FF:000002">
        <property type="entry name" value="Signal recognition particle subunit SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038995">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="582"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY95518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="613" mass="67250" checksum="A4B1C084A92F93CB" modified="2018-10-10" version="1">MEITDFIFSQREDSLLTGNYNAYRTHTTRKLHKVRQRLGQTTPKGRKYTAKRPVTADDVNSNVEYAHVLLISAERAWAHAMLMKSTHSADPSAKGISGATRSHIISKLQKAATYARQLVLILEDQATSGAADTDVLEARAYLASLLGALYLEKRNWGQCLQNYSISRVIYATLGQQVKKDAFRDLLSGTVDPSIRYAAYQLKLPRSKPIPSLALSYFPADATIRSEVEKLDPNCLKEEAAGTRRTADGEVQQLPESITWRSHTVGLEDAAISQALAAAAAAESRLGTWLAESAGKSASSKDKAAAYDNVIIASQDAVDATKTAIDDLVGEGVDQGDKRMQALQITRTAVNYDLVGWRIGRNRVLCGENDGTSFEPVPAKLPKGAKSSAKQDEATGKKLARLRERVVLYDSTLQSIEFILELPGVAADTAFVRELDAKRRYFRALRCLTIGRSHGILGKSTNALALFAQALALVTEAARSSQSSAETEGPPRLDISRSQVQNLESTLKGLVAQYRGLVTLEKISSEAQSKSTTQRPAVERLHEYAGDALNLTNIVPYPPQMQPVPVKPLFLDVAWNYIDYPRQDKPAQEQGPVQTETETEEKKGGRRGWFGFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFZ7</accession>
    <name>A0A317XFZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_530482</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472501.1">
        <property type="nucleotide sequence ID" value="XM_025610682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFZ7"/>
    <dbReference type="STRING" id="1450535.A0A317XFZ7"/>
    <dbReference type="GeneID" id="37112825"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="217"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY95740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="254" mass="29025" checksum="8AB3D038DB11C1B6" modified="2018-10-10" version="1">MAADVSYTASRMLSSDSSRDPSYDDFSFIPFLRKSYGFGLASDVPVCKAYSEGHCPLGPACPDRHPTPSRVTTSTTTASGLAPSTTHGSLVCKHFLKGLCKKGLKCEYLHEYNLRRMPECQSFSRSGYCPNGDDCLYQHVREQARLPPCEHYDRGFCELGPLCAKRHVRRRLCQYYLAGFCPEGKGCVDAHPRWSENLPRPQIRVEKTEEELERERALIREEQEKEKEREREWRSERGRGGGFMRGRYRGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGW2</accession>
    <name>A0A317XGW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type III domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_552214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473389.1">
        <property type="nucleotide sequence ID" value="XM_025613587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGW2"/>
    <dbReference type="STRING" id="1450535.A0A317XGW2"/>
    <dbReference type="GeneID" id="37115730"/>
    <dbReference type="OrthoDB" id="1896086at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029167">
        <property type="entry name" value="Mug117"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF7">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15474">
        <property type="entry name" value="MU117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016264148" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="703"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY96628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1030" mass="112532" checksum="58E34231C9148B5F" modified="2018-10-10" version="1">MYSQLWNGLAVIATLGSCVLADHRLHRHVRGNSSVEWDHLMMRDDDTTEFDPTDLSYIQSMAAIGDSYSAGIGAGERLGAITQALQPESVIADVINNQIPSINGNQQVIMLSAGGNDVELSNILNQCIFQWAVLNSNQVAVTKAAALADPDYTWAGSYDWDSLGLGCDGQLARTRNLIAGDAFSKSLDSVIEAAKAKLGSKGMIYYTGYAKFWAEDLSSACDSVSWATWIYNSQKLTTDHRRTMNELVDSVNAQISAAVDGAGSQVKFVNYDSYVGYFNGRFCETGVDESTAESNTSSILGDPLGRNPYKRSQDNPLNGTFEGSVNQLAQITLLMDPDATLSDQAFVSDAATVDATTAILGESKISLSAESSDLEVPNILPDGYWRVFHPQMLLHELIAELVIYEMVNFNEQDNGYPAIPEQFTFDSCPYYPPTNGSNGTTDGQQIALASYINPLSDPAAWNRIIDYPGDKVTVLVANILNVPDTTVDVDWQKVINRAYSAGKRVLGYVRTGYLGVSQDHFQTRLGSSDLADWWYKLYPGVIGGIFFDEGWNDCGTDNQYSELYRFITDTKKRKHPGAFTVLNPGATMPQCFEHSADTLMTFKNSYDTYMNHYVANPDWTPSDSRKLWHIIYNVPADKAGDVAALARERGAGLIHITDDNLPNPYDTLPDDTYMQTIMSALDGGGPAIADPSAYSDPGDSASQPSSLSVTFSDYSSVTLSWDANSKTPYAYAVCRDGTEVVRLPGTMTKVIVGNIDSGSSMTFTVRARGTDGTETSDSNSVSATTLSLPDNQAVTNVKSLSTATSTTVQADILVPFAFVRVFLTDPDTRCSMPSWPINYNTGNFICTHYMVEGSALYQYTGANLTDGQTNYPWTWTSINTAPVSRNGYTYTWTLPIGSSTTDPNYFVVEAQGYNPITNVFHPCPSTGASCTGKAPYDCKGETLCSTLNVKCNCWANWEQYGCSVQVRGKDQNMNNCQITGDEMWEAYQDIRNIGGCKKCGTKHFGNGCLVSVDYYYGCDNRDNGVNSLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGZ9</accession>
    <name>A0A317XGZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_6122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473081.1">
        <property type="nucleotide sequence ID" value="XM_025616659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGZ9"/>
    <dbReference type="GeneID" id="37118802"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="164" mass="18002" checksum="4B0BBC717EEA608F" modified="2018-10-10" version="1">MERTSDMAGRGLFVQVPSSLVVFQVPSFPARSLPALLALLRRAPVPPAPPPTCEKANRREGRPGFTSVRYVIRSHYSSAMGPRVAYEIMSHCSVSTCGGGASIYGPHWWSSRLLLCTICIPSDHIEQNKTNLANDSEGLDTRQRAGLIKCRPTTDYPDETPCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UTL1</accession>
    <name>A0A317UTL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_561563</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000058">
        <property type="protein sequence ID" value="PWY65374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461440.1">
        <property type="nucleotide sequence ID" value="XM_025614228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UTL1"/>
    <dbReference type="STRING" id="1450535.A0A317UTL1"/>
    <dbReference type="GeneID" id="37116371"/>
    <dbReference type="OrthoDB" id="10266451at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.280:FF:000005">
        <property type="entry name" value="pH-response regulator protein palC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="4">
        <location>
            <begin position="62"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="427"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="541"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY65374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="587" mass="64114" checksum="59A9773D3E764067" modified="2018-10-10" version="1">MPQNWTAQFRDRTDSRGLRSEHGIRRLDVSERKGWTRLGLKNILQGSSSTFICLARALLHFSLLQPPTSITITMVYNFTLPSTSHLSFQTFFTSSTHPSLPQAATTARHALRQALKTHKRLPRGPQQDAHLQILLTTITSYLPYLLALSDGLSGKPTDLSAFTSTTEEIEITLRTEITSSWRPTLTNPTLSLKQRPSATRVHGQGLDFEIAFVLSTLSYVLNTLARIGVTRTLYASTTPTPEQRTAAIQTATKNLLQASAVHSLLASSPSFTTVSRSIANGNGAYSLPDLDPATQAALSCLALAEATLLAVLKDDSYVAACIQARNPNDKDWMVRAPEIPKVRAHLFARLCIRAAEYAEQAAAGLGSVRSEGRMGIDEDLLGYARVLGRVARARACRFFGVDAELSGKIGEGIAWLRAAKGALGVRGAGSGGEAKEMSTKSRGLSRLKQGWMERREERRMEKDAGSRDRTEKGELGPGDNAGREEESRVIEMLETKWVRMNDTINTQLIPSSTELLANLPSGRDIHAPPAPYKIPCLDEEQLVRMRAPPAEDESGPGSDDDSDEEPGSVARVFTPGTVPERSESAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UUC4</accession>
    <name>A0A317UUC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_540919</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000065">
        <property type="protein sequence ID" value="PWY64969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461344.1">
        <property type="nucleotide sequence ID" value="XM_025613017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UUC4"/>
    <dbReference type="STRING" id="1450535.A0A317UUC4"/>
    <dbReference type="GeneID" id="37115160"/>
    <dbReference type="OrthoDB" id="5417844at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016462471" description="Rhodopsin domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="9">
        <location>
            <begin position="2"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY64969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="210" mass="23521" checksum="3222A50FE47DFEB5" modified="2018-10-10" version="1">MVLAWAVACVLIVCLQCIPLRGYWDKSVPAKCGVNEKDYFLGKSIPDTVTDLFILVIPMHPIWHLHVNRMQKLVLTLTFLIGGLVTVISIIRLVCLLEIDLSSEDITWNFVPYLIWTCVELNVGIVAACLPCLRPIYIWLRKKAGYSTGSSGSERPTPGTNRKSSRSGWSGRDEYGDQVPMHGIKFRQDFLVQTTTASDRGDEEAAEVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UUJ6</accession>
    <name>A0A317UUJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_480236</name>
        <name evidence="1" type="ORF">BO94DRAFT_480482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000077">
        <property type="protein sequence ID" value="PWY64517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFK01000060">
        <property type="protein sequence ID" value="PWY65275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461400.1">
        <property type="nucleotide sequence ID" value="XM_025608783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UUJ6"/>
    <dbReference type="STRING" id="1450535.A0A317UUJ6"/>
    <dbReference type="GeneID" id="37110926"/>
    <dbReference type="OrthoDB" id="4509140at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY64517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY65275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="89" mass="10537" checksum="8F685EF3245153E7" modified="2018-10-10" version="1">MQLDQFLNPLEEQYTAVEDEVEEDDEMIEPLPFISSTRALQALYDLRLYEEQQNDANQASLHSLACQERDILRRKVLNTQQSDIRGYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UV98</accession>
    <name>A0A317UV98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 16">C-3 Sterol dehydrogenase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">C-4 decarboxylase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Sterol-4-alpha-carboxylate 3-dehydrogenase erg26, decarboxylating</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_339136</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000058">
        <property type="protein sequence ID" value="PWY65356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461422.1">
        <property type="nucleotide sequence ID" value="XM_025607021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UV98"/>
    <dbReference type="STRING" id="1450535.A0A317UV98"/>
    <dbReference type="GeneID" id="37109164"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000346">
        <property type="entry name" value="C-3 sterol dehydrogenase/C-4 decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="17">
        <location>
            <begin position="80"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY65356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="412" mass="45470" checksum="00A47AA98A84DE53" modified="2018-10-10" version="1">MSTKRPTMELGTVLVVGGCGFLGWHIVDQLLNFPSETDPSAALPKPQGDAKFDYPKLGDRYPRCIAKVAVVDLRTTHNRLPGAEYHDGDITSAESMLAVFRAVKPDIVIHTATPNVLEGNKPLLRKVNVDGTRTLVEVAGGARGDWGGKCKAFVYTSSSSVVHDTQSDLINVNEEWPLIRGALQQEYYSETKADAEEIVLKYNRASPSSMVTCALRPAGIYGEKDTTFTFKVLEHSAKASPTVLRMQLGENNNLFDFTYVGNIAYAHTLAAYRLLFTHSRYESGQGAPLDHERVDGEAFNVTNDSPVYFWDMTRAAWALTGKVVEPEQVWELPESVLGPIGGVAETVLGLLGKTPRLTRRTVRYSCMTRYYSCDKAKFRLGYRPVVPVDEGLARAVGYVVEQERLAGEKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZ24</accession>
    <name>A0A317UZ24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_528867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461603.1">
        <property type="nucleotide sequence ID" value="XM_025610440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZ24"/>
    <dbReference type="GeneID" id="37112583"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14024" checksum="0FC93091ED0A21D8" modified="2018-10-10" version="1">MTQPPKFQKVEGYPAIDPSHSSSVPSISLTVSFKVDKSGQVVRHSSSLASSSSPIPHDTSIPVIPVHPVQPASQFNHSNLILSSLALYVGSTAAYTSLGSHPLPLRPSCLSLHPHFLFFSHLFGFLDKYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZB7</accession>
    <name>A0A317UZB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_479149</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461847.1">
        <property type="nucleotide sequence ID" value="XM_025608735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZB7"/>
    <dbReference type="STRING" id="1450535.A0A317UZB7"/>
    <dbReference type="GeneID" id="37110878"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY67125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="639" mass="71165" checksum="DAC1740826017F73" modified="2018-10-10" version="1">MDDRPSQSPAAPPSPNPRSCILCNRRKVRCDRQVPCGRCVKGGEKCVFPGPKRAPRQLKRPPISEVLAQLRHLEDEVQKLRTHPPAADSGSAASSSPLGFPAERGPVGPSNQEGRLVIKENKSRYIGDEASAVLGDKIRELQDICDGSSSDDESDVPELTSLQFVGALGGNWRDHSLRDNYLQPARIQLLWRVYQNNVAPLIAVLHTPSVEVMVRQEADNINPDPAREALILAVCFAAIVSLPPDQCPAILGLDYDRALQSYRRGVDQALVRANFIKSQNICVLQAAVVFLLSLRYRSDSRLVWAASGVVVRVAQGQGVHRDGQALGLSPFDAEMRRRLWWHICVLDMISSEDQGTDTQIHPGMFDTRLPSNIDVRDLSPSLTELPPERIGATDITLAIVQCEIISKLHWSNRSYDANDPASTSDRETIVTTLANALEERYLQHLNMDVPIEWVYAMIVRLTLSKIWLSVHYRDLAGMGQTGLSQEACDDAFEAAIETVKFTILLHTNETTSQWAWLCKSYKQWHPVAFILAELCTRPITVQTNHAWDMVTEIHGQWEQDESQTSIMLRKPLKRLMERAAVARAAKMEVSPSLGTLHTAIDPALESSIPIGPETGIKSDMYSIDEFGISGMNWIWEPLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2P8</accession>
    <name>A0A317V2P8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_540524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461829.1">
        <property type="nucleotide sequence ID" value="XM_025612934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2P8"/>
    <dbReference type="STRING" id="1450535.A0A317V2P8"/>
    <dbReference type="GeneID" id="37115077"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="3">
        <location>
            <begin position="212"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY67107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="318" mass="34526" checksum="CAA747E3AA1B5341" modified="2018-10-10" version="1">MSTSFPEAIGILSIGEMGLGIAQLLIAHKYRVLTYASDRSDATQRRAWESGIELRPSLQDLVDQSDCLLSIVPPRDALETARRIVDASSARPLVRDTPLYVVDLNAVSPKTAREIASLISAAGPHLQFIDGGIVGGPPRPSPTENNSPDKPTWKCPSLVVSGPVKLPDEELSNTLNMKHISDEIGVATGLKMCFASLTKGYTSLAIQSFTTAHALGVLPDLKGLMEEYNPAGLQMAEKGLVGMPPKAYRWVREMREIGDTMRDDGGFESDLFYAVAQVYQSVANDPVLGREKPGDRQRGQTVEDVVGSLHRSLKVKME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2U3</accession>
    <name>A0A317V2U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_540630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461708.1">
        <property type="nucleotide sequence ID" value="XM_025612954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2U3"/>
    <dbReference type="STRING" id="1450535.A0A317V2U3"/>
    <dbReference type="GeneID" id="37115097"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY66510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="315" mass="35893" checksum="42B99D374776D429" modified="2018-10-10" version="1">MIGTHSPLEHPAKSSPPSLMVSPTRLLKRLVRQTCRYGWKWLMVSLALILLSASLWLYFLLAYWLAEDPRLVPETIQRARNVLLVTAHPDDETLFFSPTILHGHDNPDVTRALLVLSTGDYNGLGETRKGEIERSCAALGILPARCVVLEHGALQDNPKKWWREDVIQDIVAHYVHMWKVDLIFTFDYGGVSGHVNHRAVSAGVLQYAESFPHTPPVYTLQSTFLLRKYSSLIDLVLTSVPFSWRIVKAVFTSPGKQLVGGQDPYGDKALLVSPWRTYLVARNAFSQHTSQYSWDRVLYLVVSRYMWFNNLYRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3F4</accession>
    <name>A0A317V3F4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_540387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461937.1">
        <property type="nucleotide sequence ID" value="XM_025612906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3F4"/>
    <dbReference type="STRING" id="1450535.A0A317V3F4"/>
    <dbReference type="GeneID" id="37115049"/>
    <dbReference type="OrthoDB" id="5041285at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF2">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016285592" evidence="1">
        <location>
            <begin position="16"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="33"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY67588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="259" mass="27703" checksum="47C74762640DCD31" modified="2018-10-10" version="1">MKISLLSLFSASISALPSPHTQQNTIPPFFLLAGDSTTATQSSGGGGWGDGFINTTLHSGAKGLNYGHDGATTVSFRAGGDWATVLSKVKEYKTDYRAYVTIQFGHNDQKPANNISLTEYTKNLEQFATDVKNAGGTPILVTPLSRRNYDNTTGTPTVIQDLADQRAATIAAANNTDTAYIDLNKASTDYLNAIGPVDAYTYNLTPDDHTHLNVAGSQVFGGLVASLIDQDFPELKNDDYVVVNPALLTALAAGKYYWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5F8</accession>
    <name>A0A317V5F8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_590764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462149.1">
        <property type="nucleotide sequence ID" value="XM_025616057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5F8"/>
    <dbReference type="STRING" id="1450535.A0A317V5F8"/>
    <dbReference type="GeneID" id="37118200"/>
    <dbReference type="OrthoDB" id="1658724at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="119"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY68127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="250" mass="28632" checksum="82C3B4EE6D1B02AE" modified="2018-10-10" version="1">MNFFSDFQPAWQSLLLEYDPSLIEWTTVCTSQLVGFLVPGLVFFLLDLLQPAWARPWRKPAQFPTHLKLWKMVRCSTKNMLTGWALHGLYLWCAYPRTLFVVDSQLPTWKAAVGQYIGVFLLGEGLFYVFHRMMHENRWLYLKIHSIHHGTGVAPTGMSVWYGHVVDHFVFNGLPLALVTLVPAIVLQAHILVVEALSILALISGVVSHSGYYYRDKTVYDHWAHHENSSKNLGAYAMMDVLFDSYTASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6W7</accession>
    <name>A0A317V6W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_550960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462316.1">
        <property type="nucleotide sequence ID" value="XM_025613516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6W7"/>
    <dbReference type="STRING" id="1450535.A0A317V6W7"/>
    <dbReference type="GeneID" id="37115659"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="81"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="645" mass="73077" checksum="78A3B26155BD587E" modified="2018-10-10" version="1">MSDKETFVDLYRFLGVVEKGPGNKLNVPPPMVDWERISTWLYGDLTKADRASKPALFAGPQFRVVDTKHGCVTEAPSPCEYATLSYVWGEPREGELMASTNNIEALREKGCLFEKFQQQIPRTIRDVMTACIRLGIRYLWVDRLCILQDPGAANEALQQINKMDKIYGQSVVTLVAISATNAHDALPGVSEKRCQANGFIASQGIHFIAQMPSFDEVLTASKWATRGWTLQEAYLSRRMIHFSDSWVFMEGYQEKAIQCEDPTIFRDQTLLTKNFASHSYWKLVNAYSRRTLSIESDILRAFSGILHAIHGEDHYFFLPLSGFTKSLLWMTQSEDQRERTLPGDSVLPSWSWISRMGVIEFEHLGLFIPLAVWAISPRGRNDEKLHIINLDNPITNKSCGSWDDQRMPHIRAYGLGIITAWKKDCFPASLPAVFGLDNTWNHYIEIMISTWESLNMLFHEAHDTSNEDLEDIRQSFPIRLIHQACLRPGRILVNTQSLRLQPVPCPEGRGVRAVSLELCNDDGRIIAWCTKRAVDEERLHRNASDGNMHYDVLSLSLGLEDVYTKDKLGDYESGRAFGLNNVLAQDSAGVALRVFETRTCLAIAFKIQLMVLETRNGISRRVGLAEAYLEVWADAGPKFGTFIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V891</accession>
    <name>A0A317V891_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_550664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462647.1">
        <property type="nucleotide sequence ID" value="XM_025613503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V891"/>
    <dbReference type="GeneID" id="37115646"/>
    <dbReference type="OrthoDB" id="4388159at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY70356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="228" mass="25705" checksum="0FFF3EE067300039" modified="2018-10-10" version="1">MTKSWTCRLPHAINAPDTAPISHWPLGPCDSVVLALIGAAAYIRIWHTMPSSEKDSHRLFEAAETRRSIHDTCNMADRIWNLSTNHRRRSARIARSSIAWLPWDQPQSDCDLKRVGYAPRHEVSAYRDYQPSPPYVNRLSGSAVPQFDCVRSIPTGSVAQYNVCCDGRMWRRCIDSIWVFTDRIGRLDACLTPMGLIGATTQLNPERKGRTVEEGQNEAHYGVVGETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8H2</accession>
    <name>A0A317V8H2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_610826</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462429.1">
        <property type="nucleotide sequence ID" value="XM_025616613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8H2"/>
    <dbReference type="GeneID" id="37118756"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY69601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="310" mass="34337" checksum="5F24AEC5217BF30E" modified="2018-10-10" version="1">MELLFSAQPNYVSDVIKSSRCSARSRGLWTIQATSLIGEGCSLPITLMSWFRCTKQNHCIGPQTRCEPLRLYSTPGMMSYLRELIMRAEDQSATRNRPALWGPRDLGLRKGRAPILSGEAREYCFFSLSVNRGYTNIDATERKGSCILNMPLSTDPKLARVNRNSYTHDEIQLHGLAPRRRGQKANPARSLITECGSQNPLQVDVSVDTISTIRNESLDAGLSAKGNTKTDDASSSDDNIHMSFDVIVGSRWKEAIQANDIQAAKILIEEGQLEARFDHLFEGDEDVTTGLTPLLLSTFIPCTEIVKAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9H6</accession>
    <name>A0A317V9H6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CefM protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_502828</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462475.1">
        <property type="nucleotide sequence ID" value="XM_025609460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9H6"/>
    <dbReference type="STRING" id="1450535.A0A317V9H6"/>
    <dbReference type="GeneID" id="37111603"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY69647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="484" mass="52054" checksum="C514BA120E17656D" modified="2018-10-10" version="1">MAAPEKQSNDSLTHSLSGDPDLVNFDGLGDPAKAIHWPLRRKWSIMLMLSIMSFIMPLASSMLAPAVPECLADFRSTSSILGSLVVSIYLLGGAAGPLVIAPLSEIYGRSIIYHVTNALYIVFSIACALSTNLNMLIGFRFLAGVASAAVMTVGGGTVADLFIQEERGRALAIWTLGALLGPVLGPVIGSFLSAAKGWRWVFWFLAIVSGGMSGVFFIFLRETSSVIILRRKAARLRKETGKSALRSHLDVGTSPGAALKAAVIRPLKLVLFSPIVAAMATVTAIIYGYLYILFTTFTMVYKDIYGFSSDTVGLIYLGLGVGMFLGLFAFGALSDFVIKREAARHDGEMKPEYRLPPMILGGICLPVGLFVYGWTAKSHVFWFIPILGTAIFGFGFIVFFMPTQAYLVDAFAHNAASALAAGAVLRSLGGALLPLAGVPMYDKLGLGWGNTLLGLIAIATIPLPFFLLRYGERIRTSPRFQVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9S0</accession>
    <name>A0A317V9S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_266206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462699.1">
        <property type="nucleotide sequence ID" value="XM_025606523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9S0"/>
    <dbReference type="STRING" id="1450535.A0A317V9S0"/>
    <dbReference type="GeneID" id="37108666"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000156">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF316">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016318400" evidence="7">
        <location>
            <begin position="20"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="3"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY70805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="422" mass="46510" checksum="4A3C88A732F976BC" modified="2018-10-10" version="1">MSNIAIIGAGLSGLALALALHQQSIPCTIYEARSAPLNIGGAIMLSPNALRILDHLGVYTRLLPDAYLFDHLHFRTTTDTPLDTYEFGNTTKYNYPGMRIYRHVLIRELSALIHEAGIPIHYNKKFHHILTESPTTVIWEFTDGTTASATCLVGADGIHSTVRKYLYPDLEPQFTNIVGVTATIPTSQLNLPSIYPLPVTILNPTHGAFIIAPQLPSGTELLIGRQKHSPHLTRKEWSSLLENKEWCVDFLREDSTSYPDLVQRAVSSINSDTINLWPFYIVPRLESWTSGLGNVVVLGDAAHAIPPSAGQGVNQAFEDGFTFALVLERCITTTTATDVGGGIPGGSGDRLKRGLKVWQKGRQERVDRVLDLNKRVDRRRMPKQSGGGGDGVDGEEEPFELEWLYKPDFGEMVEGWLAGEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VC49</accession>
    <name>A0A317VC49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Snf1 kinase complex beta-subunit Gal83</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_476379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462983.1">
        <property type="nucleotide sequence ID" value="XM_025608602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VC49"/>
    <dbReference type="STRING" id="1450535.A0A317VC49"/>
    <dbReference type="GeneID" id="37110745"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="346"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY71585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="458" mass="49409" checksum="FAFF5C497CDE897B" modified="2018-10-10" version="1">MGNNPSKGPAGDAQSPSASSGLAGEKKVARRPSIHTASSATKASAADPSATRETATGHPTSQTQPSVQQRLQSRNVAELPTRSVDRPDRQIPRKPDARYKDIPAPDQSNPVQVPGSRAAAKRDPVAPSGPPPNAYYSASVHLQRPPRMPLPIGDATATPGSPIIGPEDSYMGSVPPDHLLDEPNDPRHSNLGGAPVDDDEALDELQPYAPSGVGRAVPTLIEWTAPGDKVYVTGTFVNWEKKFRLHRSENNPGVLSTKLNLRPGTHHLKFIVDGEMRASDNLPTAVDFTNHLVNYIEISADDINRSRRESDRIPDGIRPPQVLPGPVGADQDGSTVEEQSDKEEPEEIPLGDFRGIIPQFLLDLDREEEAPEYQQAVNIVGDAPTPPSLPLFLGKSILNGTTPMKDDSSVLNYPNHTVLNHLATSSIKNGVLATSVTTRYKRKYVTTILYKPTGDITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCR7</accession>
    <name>A0A317VCR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative catalase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_525912</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463021.1">
        <property type="nucleotide sequence ID" value="XM_025610332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCR7"/>
    <dbReference type="STRING" id="1450535.A0A317VCR7"/>
    <dbReference type="GeneID" id="37112475"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="11">
        <location>
            <begin position="5"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY71785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="491" mass="55768" checksum="32A7B02C523EB7AC" modified="2018-10-10" version="1">MSHYTLAEGCPYARNDTSVQLRNGSGGGLVLLQDTQLIETLAHFSRERIPERTVHAKAAGAYGVFECTHDCTDITSASFLNTVGKKTDVLLRVSTVGPESGSADTTRDVHGWGMKLYTDQGNLDWVFNNTPVFFVRDPIKFPSLNRSHKRHPRTHRPDANMFWDFHTANPEGIHQIMHLFSDRGTPASLRHMNAYSGHTYKFTKEDGSFKYIKIHIKTQQGIKNFTREEATKVAGENPDFLLEDLYDAIESGNYPVWNVYVQVMDPKDAETYKWNIFDMTKVWPHQDYPLRQIGRLTVNRNPRNYFTDIEQAAFSPSNMVPGFAPSADPMLQARMFAYPDAARYRLGTNYQMLPTNAAHVPVYCPYQRDGFMNFTNNYGDDPNYIGSSLRPTTFATTSNGPVSSTITEHEKWIGEVSSFTTTISDVDFEQATGLWKVLGREEGHQDRFVENVALTVQKVTRKKLRGMVYDLFRRVDPQLGARLEAEVEGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCS1</accession>
    <name>A0A317VCS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_250875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463116.1">
        <property type="nucleotide sequence ID" value="XM_025606434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCS1"/>
    <dbReference type="STRING" id="1450535.A0A317VCS1"/>
    <dbReference type="GeneID" id="37108577"/>
    <dbReference type="OrthoDB" id="4426556at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF61">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="80"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY72163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="580" mass="64649" checksum="FC47747B5FF6D5D7" modified="2018-10-10" version="1">MSAPAENRRPQLRRGSTRHTNEFDDTFAGRSRSFFRRESHVGVVSHNDLRDREDIEIHTWNGKDDPDNPFNWSTTYKWVLTLTVCFISVLTGIPAGSYGAGNDWMASQFHVQNTPFPNLYWATTSWNMGAAFWPLIFVPLTEASGRMPGYFVAYIILIISLFPSAFAQNYATLVVTRFFGGGGSSVSINIVGGSISDVWYGDKARSLPMSIFGLTSVIGIALGPFVGSAIVSIHKDEPWRWIFYVQIIYLTGLLPIFWFILYETRADVILARRAKKLRKETGRPIYAEAELDNTSVWRLLQISFERPTRMLLTEPVVAFFTLWISFAWGILYLFFSSVVQTFSTNYGMNVLQTGCIQLAISVGAVIGTIINPLQDIIYLRSAKNNKEKPGKPVPEARLYTSIGGSLLFAGGLFWYGWASFPSVHWIVPTCGIAACGIGIYSIYMAVVNYLTDAYEKYAASALSAASLGRNSFGAFLPLASYQLFENLGYGWAGSLLGFIGLALSIVPVVLVWKGPEIRRRSPFMREATFGTDEEEDVVMEKEGDGETTGTVYRDTHTGYPQHDTQRLNVNGQEERPGDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VED8</accession>
    <name>A0A317VED8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_539400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463045.1">
        <property type="nucleotide sequence ID" value="XM_025612700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VED8"/>
    <dbReference type="STRING" id="1450535.A0A317VED8"/>
    <dbReference type="GeneID" id="37114843"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY71809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="526" mass="56888" checksum="AE82D463C3D2F48D" modified="2018-10-10" version="1">MGFLLKKPDDAAGSAAPAIIIGLFVAFGGLLFGYDTGTISGILAMKYWRETFSTGYINPTDDFPDVTSTQSSMIVSLLSAGTFFGALASAPVADYFGRRIAMIIESFVFCFGVILQTAATSIPLFVAGRFFAGFGVGLLSATIPLYQSETAPKWIRGTIVGAYQLAITIGLLLASIVNNATKDRMDTGCYRIPVALQFAWAIILVVGMSVLPETPRFLIKKDRHEAAAKALARLRRMDVDDPALVNELADIRASHEYEMSLGKASFRDILRGSLGKRLATGCAVQGLQQLAGVNFIFYYGTTFFERSGISNGFVITLITNIVNVVSTFPGLYMVEKWGRRPLLLFGAVGMCVCQLIVAIVGMVATSDVANKVLIAFVCIYIFFFASSWGPVAWVVTGELYPLKARAKCLSITTATNWLLNWAIAYATPYMVDSGPGNANLQSKVFFIWGGFCFVAGVFVYTCIYETKGLSLEQVDELYSSVSAAWRSPGWVPSAQFDGDAGKAGVSVSEVEGELPVKREAHHIEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VEZ5</accession>
    <name>A0A317VEZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Decapping nuclease</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_258852</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs. Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates. Stimulates exoribonuclease activity of Rat1, allowing it to degrade RNAs with stable secondary structure more effectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside-ribonucleotide in mRNA + H2O = a (N(7)-methyl 5'-triphosphoguanosine)-nucleoside + a 5'-end phospho-ribonucleoside in mRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66928"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17313"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:172876"/>
            <dbReference type="ChEBI" id="CHEBI:172877"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:66929"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60880"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:60881"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78683"/>
            <dbReference type="Rhea" id="RHEA-COMP:15692"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78684"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DXO/Dom3Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462920.1">
        <property type="nucleotide sequence ID" value="XM_025606470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VEZ5"/>
    <dbReference type="STRING" id="1450535.A0A317VEZ5"/>
    <dbReference type="GeneID" id="37108613"/>
    <dbReference type="OrthoDB" id="5853397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034353">
        <property type="term" value="F:mRNA 5'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110155">
        <property type="term" value="P:NAD-cap decapping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013961">
        <property type="entry name" value="RAI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039039">
        <property type="entry name" value="RAI1-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395:SF9">
        <property type="entry name" value="DECAPPING AND EXORIBONUCLEASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12395">
        <property type="entry name" value="DOM-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08652">
        <property type="entry name" value="RAI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RAI1-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY71522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="368" mass="42477" checksum="4393018AFA22C89D" modified="2018-10-10" version="1">MDRKAFDIQPIGRFYEASAAIRRPKEIACFSYDDEHKFHLGESSMKYYYPPPLPADLNRGFESFQKLDDSADEHLDALLETIMALEKETAKQCEADIVTWRGMMTKILAAPFDHLNGFEMNATCFQGTIFIEENNSYKNEQKQIQKNQRMPPGMASQELMAYWGYKFEALSVLNQPWDPTPRKEIEYREELVVNNNAQYCSVVRTAIGRTRLVIGGEVDAVWDCKPGRKEDPIHWVELKTSAEIRNDRDMVKYERKLLKFWAQSFLLGVPKIIVGFRDQQGIVHRLEELETASIPAKVKQVGRGTWDGNICISFAATFLEWLKSTIHEEGTWRIRKREKSSLIEVFKLEESGTGDIISPAFSAWRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFG4</accession>
    <name>A0A317VFG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_569186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463162.1">
        <property type="nucleotide sequence ID" value="XM_025614727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFG4"/>
    <dbReference type="STRING" id="1450535.A0A317VFG4"/>
    <dbReference type="GeneID" id="37116870"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY72209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="306" mass="35509" checksum="EE46B5D0192FB189" modified="2018-10-10" version="1">MTNNPCTACSWSSERQRNCSYESDVKLVHASRNRGIWAIGSSLILKDRGPMHRTYEVFNAHLVRESTTIPVPTVIGSWKENRRTFILMKRIPGESLRELWPRLSLKEKESIAKQTADYISQLRGLQNQKIQGVGGRPIYSSLLFPYKRADNPFPPHGPFSSDDELWADMGLGITNNHPKSMNEDLRRVMPPGRPYTFTHCNLAIENIMVEDGKVTGILDWECSGYYPVWWEYVCTSAATSQEDQEWKALLRKQMRDYTRARDWWSTYCMTEKDDESERLIRDDTQSERMADSDSDGSIEVERRYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VH08</accession>
    <name>A0A317VH08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_560156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463125.1">
        <property type="nucleotide sequence ID" value="XM_025614127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VH08"/>
    <dbReference type="STRING" id="1450535.A0A317VH08"/>
    <dbReference type="GeneID" id="37116270"/>
    <dbReference type="OrthoDB" id="5229017at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="382" mass="43526" checksum="9353DFC27CC1D971" modified="2018-10-10" version="1">MESENESSETWEVPIMLSPDYEELARFNPFFDKIMDLWSKSAMITNTMNSSDASASTSPSQSMDSGNDSSFNHRQSSTSPLLNEYQSRLEQHVSEQSRVELHHSGRLESDCMDSSSIEAPLGPMKTSHKKLFGENGWLGCTADMKDLPSDTKMFKGLRGFGRKIKKQVEELAEEMAKAHPNPLIHVSLRPRIVPESTIPISLDPPTQAKLYSEMEVMICVTANKFLLDQYNEGRLSEESIRKVTKYWGSKNRPQVIEFQFDQATQRRLIMSNIRTLRFSGEFSTNPVLLKSNLNNWKAVSKEMSVRTFCAPDSAIRKHMHDIHKILDMLDAPLVTYITFEELQMRTLSLMKAYLEKLCQADGGNSKLSRSSRNYGRHLSMAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHF8</accession>
    <name>A0A317VHF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein L34 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_475055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463556.1">
        <property type="nucleotide sequence ID" value="XM_025608546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHF8"/>
    <dbReference type="STRING" id="1450535.A0A317VHF8"/>
    <dbReference type="GeneID" id="37110689"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY73804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="117" mass="13278" checksum="75EFDDADD3EA8123" modified="2018-10-10" version="1">MANNRLQYRRRNPYNTRSNQVRIIKTPGGELRYLHIKKKGTAPKCGDCGIKLPGVPALRPREYAQISRPKKNVSRAYGGSRCAGCVKDRIVRAFLIEEQKIVKKVLKESQEKAAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VI95</accession>
    <name>A0A317VI95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial import translocase, subunit Tom22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_475300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463444.1">
        <property type="nucleotide sequence ID" value="XM_025608556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VI95"/>
    <dbReference type="STRING" id="1450535.A0A317VI95"/>
    <dbReference type="GeneID" id="37110699"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY73179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="154" mass="17314" checksum="A67BE6BBA240230B" modified="2018-10-10" version="1">MVKLTEVEDEHFSQEKPQPSKHNVLLTSDDEDEDDYTDTESEISVESDLELDTETFYDRLYALKDIVPPSTRRQFTSTVDAVTSFTKSSVLFSGKALWILSTSAFLLGVPWALAYAEEEQYIQMEREQGMIKGANEMLTPGLPAGEEKPAQPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJI3</accession>
    <name>A0A317VJI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">COPII-coated vesicle protein SurF4/Erv29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_475251</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463453.1">
        <property type="nucleotide sequence ID" value="XM_025608555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJI3"/>
    <dbReference type="STRING" id="1450535.A0A317VJI3"/>
    <dbReference type="GeneID" id="37110698"/>
    <dbReference type="OrthoDB" id="7859621at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01339">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY73188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="303" mass="34337" checksum="92466A3746703AFB" modified="2018-10-10" version="1">MAQIRGTAGYNFGHQNPFGGPGRVEATGDPSPLDAVREQTSKIEDWLDTMADPVKPYLPAIGRFLIVVTFIEDSLRMITQWNDQLLYLRDYRKIPWGVTHTFLIINMLAMSLCSFMVIARRHTEYAVAGLLAVVIVQGLGYGLIFDLNFFLRNLSVVGGLLMVLSDSWVRKKFVPAGLPQLDEKDRKMYVQFAGRVLLIFLFIGFVFSGQWSLWRIIVSLFGFVACIMVIVGFKAKWSAIILVVLLSVFNVLVNNFWTLHPHHPHKDFAKYDFFQILSIVGGLLLLINMGPGQLSMDEKKKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJV0</accession>
    <name>A0A317VJV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_240495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463397.1">
        <property type="nucleotide sequence ID" value="XM_025606368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJV0"/>
    <dbReference type="GeneID" id="37108511"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY73132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="66" mass="7255" checksum="5C1DF518E7E8E48D" modified="2018-10-10" version="1">MNITPFIDTILDHTLMKITMAPCTAYIICKMIVFMQGEDQVIRMGSTSSKKGCDRFIGDIRPGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSC3</accession>
    <name>A0A317VSC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">SET domain-containing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_568215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:10025"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464410.1">
        <property type="nucleotide sequence ID" value="XM_025614665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSC3"/>
    <dbReference type="STRING" id="1450535.A0A317VSC3"/>
    <dbReference type="GeneID" id="37116808"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-TRIMETHYLTRANSFERASE SMYD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46402">
        <property type="entry name" value="SET AND MYND DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAP" evidence="9">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="437"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY77223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="816" mass="93586" checksum="260DDC9513285499" modified="2018-10-10" version="1">MEQNPYDSTPGHETVTPPLFPPRPDLYDEVGWTPHLSRDDAKIARRFWSLPDSLLGRGLGEQSPSLRRTSGEELQAHPLHALARNVYNHMVRDHLKPLAPGDWVQRWAASGLQNQTWSFNDIFGGQGFDLGAITEDPNRVAGQLISAMKVQQLRDALEKRNISNVGTAAQLRQRLRDDKRKIYRKYRVLPRSDLSHWGIQRGDTGKYAIEITDENEIGPLDMYTCAILVSPYNPTYWLSRAYCHYQHAFFDLAVGDAYRAQLLCEVLVDPSCRNRQPGLYTRTWQAVEQHIRARDRDPATGKLYAEVDLLRNLNGINYFGHTLRKAIRHVISLSLAALQCWDDYSIKEKELGKKLHMERDEILSENRYDVMEPIIKLLTPAKSKTAPEYFFYEKRAGNVFGERGYPHDADDKDRSADEFVEKATEIFINQNGSLPWNKCKVHVDNRRNNGAQLSIVATEDIKAKEIIFVEVPPIRGHLNLRKLSKGQIVQPRLRCDNCQRGLPAGHQETYSNGVQQGNLRETCRCISKQMPIAFCPAPNQEDEACAENARARYHFRACGKDWEWLHNAMRPITDELRGTEPKGLYYTHTNEAHTTLLSLLLREVFDITLHRRERDPHLMAHEIDELLVLESPQNWQNQSFPFTLAGNVQVPFDILMQLGVDIFRDLAFDTWVIQLILKKLTAHIVPWDPELRKPTEIINEKKIPKGTIQVTLSGEDEDLAILDPTFHALYLYPGFSLFNHACPKIHNAMWGYDPEVPNRLLVWSTKPIQKGEEIRIPYIHPNDPKATKITLERVLGRPCDCGGPHIHERRPKAAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSW8</accession>
    <name>A0A317VSW8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alcohol dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_499500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464114.1">
        <property type="nucleotide sequence ID" value="XM_025609380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSW8"/>
    <dbReference type="STRING" id="1450535.A0A317VSW8"/>
    <dbReference type="GeneID" id="37111523"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000030">
        <property type="entry name" value="Low-specificity L-threonine aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041359">
        <property type="entry name" value="GntG_guanitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY76117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="735" mass="79645" checksum="93134F4A46B9B2B4" modified="2018-10-10" version="1">MTLLTNGQALPPTQWAHVFKTRGQTIELKQIPVGTPGPDEVLVQMEYSGVCHTDLHAWKGDFPPTPKQDLVGGHEGVGLVAAIGTQVNGLRIGDTVGIQFCSTGNQPLCPKLQLSGYMVDGTFQQYCICKADNAVRIPPGISLEAAAPVLCAGITVYKALKESNVQPGQVIAIVGAAGGLGSLAVQYAKACGHKVLALSSGSDKRQMCLYDLRADYFVDYKSPDVAEEARRVTGGGPHAAMIVSSVEEPFHQATQYIRPGGTIVAVGLPPGKISTDVFSMVTQKISIKGSYVGNREETEEALAILIRAGFSVQYDVVDFAELPNIYDLMERGQIKGRKVLKIGKSLTRSSENVSTFCRDLHFLPKQNGISGNVVSGELERAIERAGGDFRSDTVTVPTEPVMQAIINVSTFGDDIYDDGGDPAVNAFQDKIKALTGKEAALFVLSGTQGNQICLRTHLHQPPHTILLDYRAHVQVWETGAIPLLSQATVTSIEPKNGIHLTLDDVKDRIVEEGNIHFPPTRVVSLENTLSGSILPLEHAKQISNYVRNIRVPPGRTRIAMHLDGARLLEATTAENVSVREYLDCFDSASICISKGCGAPMGSVIVGSKEFIDRAVWFRKMFGGATRQTGMMAAAASAALDHCLPLLPKVHALTRRVAEYLRRIGYEFLLPVDTNMIVLDLKKTGVDGESVVRYCDRYGLRTFPNGRLAFHHQISEDGVARLQRALLELITDLKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTB9</accession>
    <name>A0A317VTB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_499451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464085.1">
        <property type="nucleotide sequence ID" value="XM_025609377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTB9"/>
    <dbReference type="STRING" id="1450535.A0A317VTB9"/>
    <dbReference type="GeneID" id="37111520"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF54">
        <property type="entry name" value="GLUCOSE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="10"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY76088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="513" mass="56561" checksum="020CB96E67F82154" modified="2018-10-10" version="1">MYRISNIYVLAAFGTIGGALFGFDVSSMSAWIGTDQYLEYFHHPDSDLQGGITASMSAGSFAGALAAGFLSDRIGRRYSLMIACCIWVIGAAIQCSAQNVAHLVAGRVISGLAVGITSSQVCVYLAELAPARIRGRIVGIQQWAIEWGMLIMYLISYGCGKGLAGAASFRVSWGVQGVPALILLAALQFFPESPRWLASKERWEEALDVLAMLHAKGDRNDPVVQVEFEEVREAARIAQEAKDISFLSLFGPKMWQRTVCGVSAQVWQQLLGGNVAMYYVVYIFNMAGMSGNTTLYSSAIQYVIFLVTTGSILPFVDRIGRRILLLTGSVLCMACHFTIAALMATRGHHVDSVDGNANLRWSITGPPGKGVIAVSYIFVAVYGFTWAPVAWVYASEVFPLKYRAKGVGLAAAGNWIFNFALAYFVAPAFTNIQWKTYIIFGVFCTVMTFHVFFFYPETARRSLEDIDLMFETKLSPWRTSQLPDRFGEEVERHRQKSVGEHEKEIVSTHDEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUP2</accession>
    <name>A0A317VUP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_559182</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464506.1">
        <property type="nucleotide sequence ID" value="XM_025614049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUP2"/>
    <dbReference type="STRING" id="1450535.A0A317VUP2"/>
    <dbReference type="GeneID" id="37116192"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY77319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="573" mass="64243" checksum="070AA6D95C5E64F9" modified="2018-10-10" version="1">MYKPAPPRPKKTNIVRSRNGCKSCRERKTKCDEQRPICGTCKRLGKICETIRPEIKFRMVAGPSANGKPCSPTPSQELQSQVTSEQNSLSRTFGNLDLIKSLQHVERDIFYSTYWEDSCLPALHPLFHWTSRLAGEHPILSDAILALSSCNLSRQHAERRTLSTSSMGSYSPSLVHQTRSQLYYSSAIKRFTALNQFDYQSNATMVLAVLILFAYVESSMGNFHGFNCHVDGLTRLLTELPESSGDAMMNALLTSWMQVRYVVWWARAYFSSIDVHQQLPSISLPRSLTGGCNSIQERRVTGLSIMCESHRINSQTILRHWSHGLGSKDPHQDGHQVNDEEYTTYCLLLSEQSKRLDDWLASLPPSEQPIYTDVVHNSESDDSNPPIHFQTHDAALNFAYYVVARIMQGTGILRNLHTKDPKTLDHECREEEPWVRILLQIAKGADMHTSLSRNNYTIGFSGLLLAGLLRCQSLPLGLEIQSWLQKLQDLQPTEEGAFPVYQSLGVAKAINQQKMIGRDIFAVTQPLDDGGGTPKVTAYNSQSIDNLVFYGKCRLSGCLFVDCVSIDGSDGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUT4</accession>
    <name>A0A317VUT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrilotriacetate monooxygenase component A/pristinamycin IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_537827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464565.1">
        <property type="nucleotide sequence ID" value="XM_025612360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUT4"/>
    <dbReference type="STRING" id="1450535.A0A317VUT4"/>
    <dbReference type="GeneID" id="37114503"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01095">
        <property type="entry name" value="Nitrilotriacetate_monoxgenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="7">
        <location>
            <begin position="29"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY78053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="443" mass="49135" checksum="7EF24AB347738951" modified="2018-10-10" version="1">MSEPRKTLHLTAFMRPVSLHTGAWRYPDSYADANFNLTHLKSFITQLESAKFDAFFMADHLAVLNMPTEALKRSHTITSFEPFTLLSALSAITTKIGLAATASTTYETPYHIARRFASLDHLSNGRAAWNIVTTANPESAKNFNLDSHLEHSSRYKRAREFYDVVTGLWDSFADDAFLRDKESGIFFNPDKMHVLDHVGEDFKVRGPLNIARPVQGWPVIIQAGQSEPGRQLAAETAEAVFCSPRDIASAKELYADIKGRAVAAGRKRDHIKILPAAFIVIGDTVQEAQEKRLRLDSLVHYDSAIASLSVVLGTDTAGLDPDAPLPEDLPETNASKTGREGAVKLGKEEGLTVRQLAQRYGGYSGLAFVGTSESIADEVEQWLDQEAADGFTVVFPFLPQGLEDVTRRLVPELQRRGIFRSEYEGSTLREHLGLPRPENRFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXI8</accession>
    <name>A0A317VXI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">EF hand domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_522233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464814.1">
        <property type="nucleotide sequence ID" value="XM_025610174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXI8"/>
    <dbReference type="STRING" id="1450535.A0A317VXI8"/>
    <dbReference type="GeneID" id="37112317"/>
    <dbReference type="OrthoDB" id="2122982at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF187">
        <property type="entry name" value="EF HAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G07310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="9">
        <location>
            <begin position="273"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="449"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="516"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="587"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="837"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="873"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="897"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY78505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="977" mass="109849" checksum="C4ACD786C542FAA2" modified="2018-10-10" version="1">MPDTHPRPALARYRPILYLLSGVAAAYAILYIHNHILSTSTSQNTLRRRKAVRHQRRRGEAEPANAAAADTPSSRAIAHLEQLERQNGVYGTFRIETEDGRRVESGLLPSLLATRDQLMEEVGVPQNHAERMREMMEDTFLESFLAMDFPPTHTLEEGTPERDFLTEQLQRRGISRAGIERALVRFNDDNNYGEELRRRRQNGERVTLSTSTFPEESSPAQNMDGGETVVDDQSVFSWRDGNNDSSPTREGQNLLNLLYHIAEDQARRDGYIHRGVTCNSCGAMPILGIRYRCANCIDYDLCETCEAMGVHIKTHLFYKVRIPAPFLGNPRQSQPVWYPGKPAMLPRSVSRSLSKRLMKETGFDNTEFEALWDQFRCLANHEWDDDPNKLHMAIDRKTFDRCFVPNTSIRPPPPSLIYDRMFAFYDTNSDGLIGFEEFLKGIASLNNKSNDERLRRVFRGYDIDGDGYIERKDFLRVFRAYYALSRELTRDMVAGMEDDFLEGGARDVVLGSQPISSAFPGSIPSGEASRTGEGKRINQDGDLEIVDNESIVRPDRTDTADRHSVVGDAAVRSQFGSVRPMYATAARLETPSGSGVAHASGSNTRRDIHSEDAPDDASNSSGGSDRWPPPEGQVRDHDIVDALGSYVPLNDITDPADRDRVGAAVYNRMYAQGRHNVQVTHSTGVHERWQRRRFYTDEEDGATVPQGYHSDMDVGSLTEDEDEDEVEDDEPQPESHPPSPRSRSSSKVRFQDDLTDDYDVQSNPSTSSRSILVGERWGGFEIPAVERDVGKEILYQVTQQGFNELLDLLFKPKEDLLMEAFHTRAERKMWAHEIERLEQMDSGTPVVQEERQPADEPDEPPESTMLRLDPNGTTSFPAPASPSISSPEAEATAPKHSPSPIPPLPSSPTLPRRTSPPRPPSKAKLAHLAHLEKIEREAKERGGSGAKLNFNEFAQRMAMDRGRTLAFVASWIEMASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W092</accession>
    <name>A0A317W092_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_558882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464897.1">
        <property type="nucleotide sequence ID" value="XM_025614033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W092"/>
    <dbReference type="STRING" id="1450535.A0A317W092"/>
    <dbReference type="GeneID" id="37116176"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="287"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="93"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY78588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="444" mass="48676" checksum="79B2F79D340E7D3E" modified="2018-10-10" version="1">MASTASSPPSQQTASSTLTVLPPIITDTPAKRQGRQRSSSYAKDRLSTHSNVSLASQNRSRPGSHVFPIFHSSLPYALVRDFAYPAIHPLHYGPLPPRASVVSTPASEQRRLSDPPAPWDSSRGQWSMGPWTTDHSYGHQQLPAMSFGDGPPYSEDEDLHSPVFSAPRHRKNKSTGTDLNGRKSRGPGGREHQGTSYEGDADRGTLVSMNADGSETYYVNDDDAMEDGPGGEYVTYPANESRYSHMGSYGDYQSYGHDADFDSEDDYAGDHRYSRDFQFAVGCPDEEMHGKAVALFDFTREHENELPLTEGQVIFVSYRHGQGWLVAEDPKTGESGLVPEEFVRLLRDIEGGLTSLNGEPDAEEESHTYLSPESTDSQQAITPTQDEQLPLESTYVSVEHVSNGEKRESSRLSSGGKTDSNTSHFLAGNQGIDAPQDLTEKKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2F6</accession>
    <name>A0A317W2F6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MAP kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_165096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464940.1">
        <property type="nucleotide sequence ID" value="XM_025605899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2F6"/>
    <dbReference type="STRING" id="1450535.A0A317W2F6"/>
    <dbReference type="GeneID" id="37108042"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000253">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000261">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="67"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="358"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="374"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY79368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="541" mass="58747" checksum="7D93CF3243280746" modified="2018-10-10" version="1">MADQFKARTLKRKNVKGLALNAAPKPTANNSDGDGQASGAAGNGESNRTDTLEIGLEFRLDLRSEDLVTLKELGAGNGGTVSKVMHASTKVVMARKIIRVDAKENVRKQILRELQVGHDCNSPNIVTFYGAFQNEARDIVLCMEYMDCGSLDRISKDFGPVRVDVLGKITESVLAGLVYLYEAHRIMHRDIKPSNVLVNSRGNIKLCDFGVATETVNSIADTFVGTSTYMAPERIQGSAYTVRSDVWSVGLTVMELAVGRFPFDTSDSSAGDRASAGPMGILDLLQQIVHEPAPKLPKSDAFPPILHEFVAKCLLKKPEERPTPRELYDKDAFLQAAKRTPVDLQEWAISMMERHNRKSYLAPPPPKSLKEEPPVSQSTPSPKPQASSKPARTPQFIPGAAPGDVPFNNIINNNNNNIGRDSPSHYQYNYPANPSPRPTRSTRSPPISLEHLSLEDEYRSGRRPSRTPVGGASSALEPPMHLSMGSRSASSHNTKSRMPLQSAALPVRGPPPSGPPPPAPGSGSWQRQPGSMRGDHMTGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2R7</accession>
    <name>A0A317W2R7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Probable beta-glucosidase G</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Beta-D-glucoside glucohydrolase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Cellobiase G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Gentiobiase G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_470491</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465375.1">
        <property type="nucleotide sequence ID" value="XM_025608335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2R7"/>
    <dbReference type="STRING" id="1450535.A0A317W2R7"/>
    <dbReference type="GeneID" id="37110478"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016458860" description="Probable beta-glucosidase G" evidence="19">
        <location>
            <begin position="23"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="734"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY80773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="819" mass="89744" checksum="EECCFACEE6947086" modified="2018-10-10" version="1">MKVPADYTALLSGLLLAPSVGASTCQTPVDHPGTAFSFVQPLNTTIYSPYGHSPAVFPSPKTNGNGGWEKAMAQAKDWLSQLTVEEKAWMTTGQPGPCVGNILPIPRLNFTGLCLQNGPQCLQQGDYSSVFVSGVSAAASWDRKLLYDRGYAMATEHKGKGTHVVLGPIAGPLGRSPYDGRTWEGFAADPYLTGVCMEETIIGMQDAGVQANAKHFIANEQETQRNPTYAPDANETTYIQDSVSSNVNDRTLHEIYMWPFANAARARVSSFMCSYNRLNGSHSCQNSYLLNHLLKTELGFQGYVMSDWGATHSGVASVESGMDMTMPGGFTLYGELWTEGSYFGQNLTDAINNGTVSTDRIDDMIVRIMTPYFWLGQDQDYPSVDASVGALNTDSPPDTWLYPWNFTGPSNRDVRSNHSQMIREHGAASTVLLKNVRNALPLRKPRNIVIVGNDAGPVTQGAYNQNNFEYGTLANAGGSGTCRFSFLSTPLNAITARARQDGALVQTWLNNTLITEKAMPDLWNPEQPDVCLIFLKGWSEENVDRRFLDLDWNGNAVVEAVAKYCSNTVVVTHSAGVNVLPFADHPNVTAILAAHYPGEEAGNSLVDILYGDVNPSAKLPYVIAYNESDYNAPLTTDVQTNGTYDWQSWFDEELEVGYRYFDAHDIPVRYEFGFGLSYTTFNLSRLAATAPVATNLTAFPEQRPTQPGGNPALWDTVYTLTAQVSNSGSVDGYAIPQLYVGFPDTAPAGTPPSQLRGFDKIWLEAGETKTVTFELMRRDVSYWDVVAQDWRIPAGQFTFKAGFSSRDFRAKATATFVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W472</accession>
    <name>A0A317W472_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_602028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465371.1">
        <property type="nucleotide sequence ID" value="XM_025616404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W472"/>
    <dbReference type="STRING" id="1450535.A0A317W472"/>
    <dbReference type="GeneID" id="37118547"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016337576" evidence="1">
        <location>
            <begin position="23"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="485" mass="53638" checksum="BDAF6561CF0DBEAF" modified="2018-10-10" version="1">MANPIWLTVLVLTLGLTLHVQAKDVFAHFILDNGANFTQKHWNRDFTAAKSASIDAFALNTGYGPSNTYALLNDAFTVAATLDFKLFLSLDYSGDGHWPPDQVIKILQNYTSHPAYYKIPGTNKSLISTFEGYESLNDWTNIKQKVPDLFLVPDWSAQSPESLVKDSVVDGLLSWDAWPYGSDAMNTSADERYISALKRADKPYIMPVSPWFYTDMVRYHKNWVWQGDDLWSVRWDQVLDLEPEFLEILTWNDFGESHYIGPLHENELGIFDYGQAPFNYAAGMAHDGWRDFLEFRIGEYKNGSGKGRIGSEGVVVWYRLTPGWACEAGQTTGNAVSQGQRTMPPGEVLTDTVFFEALLERDATVEVSIGGGNASVGWSGTPQGGRGVYYGHVPMDNRTGEVVVTLSRDGRFVAQMNGESITTKCPEKLTNWNAWVGSAMANGTNATTSRASVEKSGAVAVLVSGGRRGGVLNTVISNILDWTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4P0</accession>
    <name>A0A317W4P0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_536853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465654.1">
        <property type="nucleotide sequence ID" value="XM_025612129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4P0"/>
    <dbReference type="STRING" id="1450535.A0A317W4P0"/>
    <dbReference type="GeneID" id="37114272"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016394247" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY81586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="381" mass="41214" checksum="BC9560F2406694DB" modified="2018-10-10" version="1">MIRAILCSVIPFLISLGQTAFVPLPSGTGPCDVTLQASELVDQSRIDPFDPKGGKRSIMITTFTPVNCGSVLPTSYIPNATAQYEDNFFQSFGIAPGTFESFRIQTQTQQPSSLQANHPVVLFSPALGTSRLMYTSLLQDIASNGFAVISVDHPYDANIVEFPNGRTVLGILENTTTNAQYTFAMNVRVQDMIFLLNQTHNATVLRDIFPLSRKAPNLLSLDRVTIMGHSLGGATAAQTILLDNRFVGGINLDGSLWGSVVDKGLSSPFLLFANADHNETTDPSWGTFLANSQGWKLHLQLAQSKHYTFSDFPVLVDALAISEAVKEVIQADWIGTIGALRAKNVVVSYVTATLRYLVSGRMSDLLSGPSVAYPDVSFVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4S7</accession>
    <name>A0A317W4S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_625734</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465642.1">
        <property type="nucleotide sequence ID" value="XM_025617304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4S7"/>
    <dbReference type="STRING" id="1450535.A0A317W4S7"/>
    <dbReference type="GeneID" id="37119447"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="290"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="568"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY81574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="679" mass="75456" checksum="546F1AD0DEDBED74" modified="2018-10-10" version="1">MRRVQGQENTMQIIRQYGCLRLLPVLTPLTPVYQTIRELPGPQPGSEHAAYHPTQPSTLYIDSLLANRQASRRHGGASHPDQLTTIFGPNPNISFFPAKRVRAISDRLGHSRLDQLLDEIRAVVATKVKNTCAIPQTYSQRHRDAGRNNDLPSTDIIAGHIAGIHKFSMSHLPHANDPVLCYAAYFDTVHPIYPFLCPDTFRERTLGHNLTQSLIADKSWAALFYAIVAIGCQNNDGGSFEAGVGEAWSYFERSLSYFQELLFGRGSLTAVQALMAMAIFSSTVSAFQFEPLMLSEAAIMAQGLGYHRSNSPQEGPCRRTFWVLYFMEKTSCFATGKTSVLEDANISCAIPDVPESTFHDYDWFFNFVKYARLVSKIRQSLFTISSVSQPLSSYNSVVESLRMELETWRLTAPPRFRPGETLKTRLLRETLAVQVALITHFLYLNALLTLSWTVLHHGAVRLGTTQQEVMKRELMRTARSVLELTVFIEVAPSTPVWILAVLPLSSLMILFDLVVHNANHPETGLSLALLDIAGGHFSRLEYASNGALPGSLVAEFAHLARQYVSETRKSKSRDCSEAGPPQAPVEASPSVPQAMRPTTTTAATTTSQLQNAVSALPQGPVNDLPIDMQPWSPASLDRNESLFLPYIDDPSYYFGDLQLLGIDVRDLFDHPYQLPGSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8M9</accession>
    <name>A0A317W8M9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_536859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465660.1">
        <property type="nucleotide sequence ID" value="XM_025612132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8M9"/>
    <dbReference type="GeneID" id="37114275"/>
    <dbReference type="OrthoDB" id="4473276at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY81592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="248" mass="27602" checksum="91C6533DC151638C" modified="2018-10-10" version="1">MATTTTTSVRYSTGKVATSESAKAFPWEAPIPVDPFWDSFEYCTARSFLSNFTDDELAKLPIDAYSTADHQTKLGLLLQLLNDKLTQEEAATSPPQSLYEADYKRWYSLWSGIFTIQNNLNLPEAEQTVRMLVEKRPDPNNVDPSHMLAEYLVKVGKYEEAEETAKPVCAGMDALPRLGKDSPQALNARRFIAKAVWFQGPGRREEAEALVAELKGLVDGMGAGKFGVYQEEERRLNGEMLAELGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9B1</accession>
    <name>A0A317W9B1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_536667</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465981.1">
        <property type="nucleotide sequence ID" value="XM_025612068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9B1"/>
    <dbReference type="GeneID" id="37114211"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="135" mass="13582" checksum="95A8911D49D29323" modified="2018-10-10" version="1">MGNICSRSSNPSDSEAFSTPGRVLGSHPPDDPAPRAPLPSNAKANRAATGPGPGRPVGPAASGGAEGGANPDARMNAALAAQKRAESASTANKGKLGSKLAAQKAQTQTQTLNEVSRDEVAARDADGAAEARRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9I5</accession>
    <name>A0A317W9I5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_470523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465362.1">
        <property type="nucleotide sequence ID" value="XM_025608339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9I5"/>
    <dbReference type="STRING" id="1450535.A0A317W9I5"/>
    <dbReference type="GeneID" id="37110482"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="31"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY80760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="465" mass="50488" checksum="AEE70AC923846BA1" modified="2018-10-10" version="1">MAPADPNIVSWDGPNDPANPRNWSKAYKLVNVTLVSLSVLYVNLATTMFAPGASIMKHEFGYKSSTVEILTVTIASLGFAIGQLFVSPLSEVFGRMPIYRASAIFYLGFTAGCSRSTHVAEFLVFRLCTGLSASSYMSTGGGTVADLLEKQERGVAMAIFTAGPLFGPVLGPIIGGFVTENLSWRWTFYLIMMLAGAVSTASFLTLRETSAVAILKTKAKRLSKETGNPNLRAAGDRQIPVQTLVMHALTRPIKFLYQSPVVFLISLYIAFNFGVTMLLLATFPSIYEDTYHWSVGISGLAYIGVGVGCAIGVFIFAKFSDRLVKPNGSTYRPERRLILMMFVSPLFPIGLFIYGWTAKYRTPWIAPIIGTAVCGPGAVVISSSAQTYMIDVFGPQTAASALSAITLLRNLTGAFLPLAAPSLYGHLGLGWGNSVLAFITIGFIPIPFLFYRYGERLRERFPVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBB0</accession>
    <name>A0A317WBB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VPS9 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_495473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466000.1">
        <property type="nucleotide sequence ID" value="XM_025609264.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WBB0"/>
    <dbReference type="GeneID" id="37111407"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000443">
        <property type="entry name" value="Putative vps9 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.80:FF:000009">
        <property type="entry name" value="VPS9 domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000058">
        <property type="entry name" value="VPS9 domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="342"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="243"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY83215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1305" mass="145740" checksum="FF26A36681FAFB3E" modified="2018-10-10" version="1">MHPLNPFLRAFFRSTVPGQCIPTENHVLLVPVTESLVGSRDRESSLYYADLVVSEEFLGSHTLRIPVSTGAGGGKDDSNIRDSRGKAKQVTTVNGRTVIIKENSVYSNKGFKSLSQAQLLSDALYYSNNNDSQPWLIYYISRPLIGSFDPGKIVTAVVPGMLPKRNILGNGTKSGEPVSSPPKKEIKTFGELLANFPMIARQMQPGLERLFKEFGKELGKPLPPPPSRSPLMFDDYERKQNGDEITADESASIRSSSSRNRDGLPFNSEEYFEDDEDLMRRSLETAVTAAIDLFRLVDKQQLSFLGATTDLTGPLVERLIERYVAEQVHESLLFPRLCSFRQPEDAELDSRIRYMDNIDISQVGIAVEGGREGKRELLRRIGRAVEEFRKTLDAKCPHDMLNTLLETIKLLSYPGTYDRVGSQTSEKQYAPMTINADILVSLLLVVVIRSQVKNLQARLMYMQHFIYIDDVDSGEMGYALSTLEAVLTYLVTDSAGLRRASIRNRRLWNATKGGRVMDMKAILEPNGDQESLDDVPSESEERTVAFRTHDDDVLCQTPHEPLPIPDARLETNAFSDMAHAETPSEPPPLSHVFPFQTWASASPPREIRRPIKKVSMDVRSLSESSGISLASRTTGMGSISSAIEGDSSIETLTKTQDPAGDSIPMMAVESRQPEALKYLLSLQDYYPLADILEDTNTNGTTLLSAAVQLAHVEMVDLLLSFLFSSTDKHTISSYLQKSDMHGRTAAHYLFSTPSVMRKLEGLLPWCQRDKHGQTPLFALCRSYDHPDYKSMVTEALTAAQIAQGDGKPLRLDNHVDSKGNTLLHIVSDPEITIRILQECDCDPNATNDKRFTPLMMASKYGRIDQVRILFLDPRVDVHLKESRGLTAVELAKDDEVRNRIDDLILLSNPPLAYDEQSGRVTTVVRSYFVEDATVRFVLKSGAPNPAANLADSRPASGTTFTVTTCRRTFADFENLATCLSVEHPASYMPSLSDFRSPFQIHSKPSRSVLHDMQEKLDRFLKVLLSHPTFATHEMLWEFFLVPELQPEMMADRSHRKAQVLTESINDDYEPVTPEGMRETEQFVSHAQDMVRAVHVNTRSLLRRGHALQNAASDIADAVALCASIVSTLKEPTNALPLSHVDAFTRYATHLSTSSSDSSPLLQFLTALTSIDNTTTAILSSLSRPVSLISSLSSTNRSLSRNRSSLVASSLPRKFNLNFPGLEESRQKSARDLEAKIQESETQIARLSREITWNKDVVVGELAGWTTWREKVGRDAIRSFVRATLVRERERGKRLERCLRGVREMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCA4</accession>
    <name>A0A317WCA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_116026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466327.1">
        <property type="nucleotide sequence ID" value="XM_025605539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WCA4"/>
    <dbReference type="GeneID" id="37107682"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="152" mass="16591" checksum="D1012ED56479FEED" modified="2018-10-10" version="1">MGTMTKKGVGSSLAQWSHFSRGRFGFLLRLALSRAGHRGLGPKAQAKHGVTWMTSSLGASPWGTNLFRPLSTVPCPCRAPRVGGPSTITNPDIHVTIFTDVTGQDRHWGAYDMLKLGSLYPAGTPTVQASAYDYPERRLRRGGDSGRTYWIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCB4</accession>
    <name>A0A317WCB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_468609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466337.1">
        <property type="nucleotide sequence ID" value="XM_025608260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WCB4"/>
    <dbReference type="GeneID" id="37110403"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="3">
        <location>
            <begin position="3"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY83869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="268" mass="29673" checksum="EA3530E5586D9E96" modified="2018-10-10" version="1">MTLTYRDGISIAQIIIYFPALIFGYFLIWRHGIRQSLEFCYLVIFATLRIIGACCMLAAIHDASTSLYVTIGICSAIGLSPLISLCNSFLSRANTVIQINGGKSLHRACFHALHILTIIALIITILGLTSHMSLSIFEHPSSKIKIGTILFVVAWFVLCTLLGILYWKRSAIEKGERRTLLAVGLSLPFLAVRLLYSVLMWFLPSSTFNFMDGNPTVELVMSVLEELAVVIMCTGVGVVLRVRDFRGERDGDTRSTSSHRIPLNAVGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDM1</accession>
    <name>A0A317WDM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_587056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465943.1">
        <property type="nucleotide sequence ID" value="XM_025615798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDM1"/>
    <dbReference type="GeneID" id="37117941"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="115" mass="13228" checksum="EF7656CD0599D98A" modified="2018-10-10" version="1">MATIHADSTIRWTVPPERRQSLHRWIHHALIAQAHHESHLLLHTRGPGPRQGEKHKGCHGRMHPTEERIKLDKRSTQVTHLLYRLYALLRGLDPSKQSSIAPSIHSLIVMSNARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE16</accession>
    <name>A0A317WE16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 69 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466033.1">
        <property type="nucleotide sequence ID" value="XM_025612087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE16"/>
    <dbReference type="STRING" id="1450535.A0A317WE16"/>
    <dbReference type="GeneID" id="37114230"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF8">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 69 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59281" checksum="89EDE1A23DCBA0AF" modified="2018-10-10" version="1">MARLSRDGYEPVARSSLDGEEIDLEDFKSSTSYPHRRAFPVHYCLSALISAARGVRRRTRHWLPIAWNLRRLLSTIAWILLALISFTFLFVPSYTHLPLHYAALRKVVQESTKSGRGNLRNSTVFIAVSLYDKNGALAGGQWGQALLDLIDMIGPDNVFLSIYENDSGVAGEGALQQLSDRVPCNKSIVYEDHFNFTGFPTVTLPDGSEHIRRVEFLAEVRNRALRPLDEYPELRFDRLLFLNDVYFHPLDALQLLFSTNTKNGVSDYRAVCAVDFINPFKFYDTFASRDLEGYSMGIPFYPWFTTAGKAQSRQDVLDGKDAVRVRSCWGGMVAFDAGFFQHPPLHPPSITSTYKTNNQKEYMNRPSPVRFRAETDLFWESSECCLIHADIQTPPSLSSSPEEVTDTGIYMNPFIRVAYHPRSLSWLGVTRRFEKLYSLVHRITSRIAVLPVYNPRRTEVAGEEVQNKMWVADQSSPRGGKFSTVKRIANGDGFCGRWDMQVLSRREENGEGGWKFIPVPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WF00</accession>
    <name>A0A317WF00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466270.1">
        <property type="nucleotide sequence ID" value="XM_025612026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WF00"/>
    <dbReference type="GeneID" id="37114169"/>
    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="236" mass="26246" checksum="D413388ED4E05B9C" modified="2018-10-10" version="1">MWFLLSDFSTRKGGDIKLGIVIEHPYRPTSNLASEGNGLPADLALPPMGCFIERHHEHPKHGDIPVMTRVWNAFLERVVKKAQEKKPPTEEVRFDRVDQEVWTFDHELDEKCMKDIVAVPKVRKYMKSGRRSVYVITAVWITHTPLRKAVRPLPNVSGEASSGQTGSTAGAEGGGQSTNAGNDLYRRYKHQSGIVLGYRTHMIYMDGSDVKCVEPGGSSAEREQAIGCPDSLCLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFX1</accession>
    <name>A0A317WFX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab GTPase Vps21/Ypt51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_536171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466526.1">
        <property type="nucleotide sequence ID" value="XM_025611955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFX1"/>
    <dbReference type="STRING" id="1450535.A0A317WFX1"/>
    <dbReference type="GeneID" id="37114098"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000611">
        <property type="entry name" value="RAB GTPase Vps21/Ypt51, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="219"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY84601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="262" mass="27357" checksum="7FAB98223E966966" modified="2018-10-10" version="1">MSESTSTNTPKPSSSVKLVLLGEAAVGKSSLVLRFVNNDFQENKEPTIGAAFLTQKCSLPTRTIKFEIWDTAGQERFASLAPMYYRNAQAALVVYDVTKPSSLTKAKHWVAELQRQASPGIVIALVGNKLDLTNDGNDAAGETPAEAEGEPSAADGDETAGEPQEGQDVTSGDARKVPTREATAYAEEEGLLFFETSAKTGTNVVEVFTAIANAIPESSLKSGRAGGAGTGQTSLGSGRPAEDSRVNLGERGPATAKEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHW9</accession>
    <name>A0A317WHW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">GAR transformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_557451</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466583.1">
        <property type="nucleotide sequence ID" value="XM_025613931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHW9"/>
    <dbReference type="STRING" id="1450535.A0A317WHW9"/>
    <dbReference type="GeneID" id="37116074"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.170:FF:000009">
        <property type="entry name" value="Phosphoribosylglycinamide formyltransferase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43369:SF2">
        <property type="entry name" value="PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="774"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="11">
        <location>
            <begin position="819"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="297"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="428"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY84658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1030" mass="111669" checksum="475955381258B736" modified="2018-10-10" version="1">MGQSSSTQRTQHFFSFHANRGRINRDEAMNHGYNSEQTGEYAPQSGTETDDDRTHTTPVESAHLNPAAEIWQPNVPVDEQRQMRTIQEESDPQYEPGQREYRSAIFARMAARRQSTMSRLGSRILPNSVIRGLLSSEEETPAEGHAHRHGIVSRSIPRSEATHSSARFSPFSSLSSRNVSRRRSLRAPYFIPRNDTSNASDPAHSGTYLENAVENAPEPTRSSWRRSARLHRVRNSLSGPIGHMFGQSYPNMSGQEPGPTPQPPLNPLSSEDPEGFIPYPGSIGSHMDFDEPHELDSVEPAVGSTRPTSPMSSQSAQGPPGLRQFPGLLRARPSRVMRREEQTPLSRVLQLAATAIAAQLSGTTGPAMPNIQALGDDGLDGSLENFIQSLQHATSTQTSPNDTGNLAGDNSPPTPVNFLRVFRFANSDGTRPVGPLNRSTADSENTDNNGGGMDVDNPPDGPEGRTVTLVVVGVRSVPSGNGPSGDQPGNAGTGLDALLRLPFLSPGSLARNPDSNRSRFPPRPEGRPMLPPIRFHGDAPSGLNAGGETTTQQGVPTPLPRLSEMGSRVPLGSLSSAPSALSESPPGPHPPPSTPAEPGLSTVSSSASTPSRRPSTASAMSPSTLPQLDPIRPMQPTAEPVEDGVPLNTRQRRRSDSEYARHRDLGSGAVRRNGVVEPDSAAPSTGRSWLIYVVGTNLSENHPAFATPSLFTDNPTYEDMILLSSLLGPVKPPVATHEDLSTAGGLFRLVEYAGSLVAEGLEGAGTLQLPEGERCLICLSDYEVAEELRQLTKCKHLFHRDCIDQRRNRTKITMDTPVRLTVLISGNGSNLQAVIDKTLQGQLSTQIVRVISNRKDAYGLERARLANIPTQYHNLVKYKKQHPATPEGVQAAREEYDAELARLVLADKPEMVACLGFMHVLSPRFLEPLEEAKINIINLHPALPGAFNGANAIERAHAAWLEGKIDKTGVMIHKVISEVDMGTPILVKEIPFVKGEDEDLHKFEQKVHEVEWGVVIEGVQLTIQEVKEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJB9</accession>
    <name>A0A317WJB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 60S ribosomal protein L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_535883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466758.1">
        <property type="nucleotide sequence ID" value="XM_025611887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJB9"/>
    <dbReference type="STRING" id="1450535.A0A317WJB9"/>
    <dbReference type="GeneID" id="37114030"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000020">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="5">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="4">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY85741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="254" mass="27500" checksum="4D4FCF45C6F337B8" modified="2018-10-10" version="1">MGRVIRNQRKGRGSIFTANTRLNKAPAQFRTLDYAERHGYTRGVVKEIIHDPGRGAPLAKVQFRHPYKFKHITETFIANEGMYTGQFIYAGKNAALTVGNVLPLASVPEGTVVTNVEEKSGDRGALGRTSGNYVTVIGHNPDEGKTRIKLPSGAKKVVKNTSRGMIGIVAGGGRTDKPLLKASRAKHKFAVKRNSWPKTRGVAMNPVDHPHGGGNHQHIGKASTISRYAAHGQKAGLIAARRTGLLRGTQKTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJP9</accession>
    <name>A0A317WJP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="4">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_624757</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467174.1">
        <property type="nucleotide sequence ID" value="XM_025617244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJP9"/>
    <dbReference type="STRING" id="1450535.A0A317WJP9"/>
    <dbReference type="GeneID" id="37119387"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY86583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="492" mass="53194" checksum="A2521774BCA37350" modified="2018-10-10" version="1">MTADLCNLPLPIAFSNIYLNGAHTPSHSSETFSLHNPKDDTLVAENIPVADEVDVDKAVGYAESAFQGSWSKFSAAERAACFRRLVDLLEERLEEILRLDSLTTGNPVSLIPTREKGYIINCLLYYAGWTDKHRGDYFPADDGFIKLVRHEPLGVCVAINPFNSPVASLFIKAAPCLATGNVLIVKPSEKSPLGSLAIMPLFEAAGFPPGVIQVLTGDGRTGALLASHMRVRKISFTGSISAGKKIQVAAAQSNLKRVTLELGGKSPAIIFPDADLENAVTWTVNAILARTGQVCVAASRVYVHRSIIDDFLQRYTARMKAAVDDMGDPQDQGYKYGPLVDTSSFKKVSAMILRGKQEARLLVGGNRIGDRGCFIEPTVFFDPKPGAEIYQQEVFGPVSVIRVFDAEDEVVAMANDTEYGLMAGVFTADLNRAMRVSERIEAGVCGVNCVSVMNVQVPFGGKKSSGIGREFGSNALDAYTEPKTVLIYVGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKW1</accession>
    <name>A0A317WKW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_65158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467231.1">
        <property type="nucleotide sequence ID" value="XM_025617577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKW1"/>
    <dbReference type="STRING" id="1450535.A0A317WKW1"/>
    <dbReference type="GeneID" id="37119720"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="125" mass="13769" checksum="761ABA4FC8E39CD3" modified="2018-10-10" version="1">MRGTCTGISVSESPFGDAKFPHPVNPAAGQSSLWYILPSAEVLWTSIILLSILLSRYYLHRPPPTTTKVKSLPAGLCLRHPTMPPYSSAQKQQIMQFVNLTQSKDTAAAKFLKAARWNLEEAIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL98</accession>
    <name>A0A317WL98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_575221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467307.1">
        <property type="nucleotide sequence ID" value="XM_025615067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL98"/>
    <dbReference type="STRING" id="1450535.A0A317WL98"/>
    <dbReference type="GeneID" id="37117210"/>
    <dbReference type="OrthoDB" id="4510839at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="275" mass="31610" checksum="763C4B0AA9043D61" modified="2018-10-10" version="1">MSRPVPSGEPEAMNSLDSLFASQFKPRLQSQVQEVQYPLPDVQVNRVASWVDLFAETDQSLKKRSSSRRSVRRRARHFARKVYVICPELFVLCSLSYTISNLPAIASITFYSELEDWWASTSPPESLYKITNATCQSVPRDTENSRNSTEAPPGPSELRNSQECHSSPGERPNVVGRDSMWHNHNVAILYSDPGHDRYKSSRYEQASSNEINDYLNEEPNERLPKCPRLESQVLGHPTLFSNGPYLSFSFMRRYMIDKLPEQFRRGIETSKLWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLL5</accession>
    <name>A0A317WLL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_566118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467491.1">
        <property type="nucleotide sequence ID" value="XM_025614540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLL5"/>
    <dbReference type="STRING" id="1450535.A0A317WLL5"/>
    <dbReference type="GeneID" id="37116683"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF45">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY87283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="35886" checksum="EB5D27C22FDC9741" modified="2018-10-10" version="1">MTRLPLPIPSPIPPSYEPKTSLRTIPATTPIEYILSILWRDGGVILSDFIPKEELTAIDTEISPWSSTKRRSTTTTTNGPSDAFSTIPSQTTLIPGLVGKSPTMARICSGNPTLEALRTRILVDEFTINREDSVEPNRLDPLLSLSVAMNIGYGAPRQLLHRDDNVHHIRHGWKNEWSFDEVSQFGCLIAGCDVSREMGATMFVKGSHRWGDDRWAEVDDRREVCFAEMKAGSALIFLASAFHGGGHNSLPDTVRNMYGLFFVRGHLRTEENQFLAIPRSVVTGMSPKMLELLGYKKPTTALGIVDNMSPHEDVEGVWARVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMB3</accession>
    <name>A0A317WMB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_556886</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467003.1">
        <property type="nucleotide sequence ID" value="XM_025613897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMB3"/>
    <dbReference type="STRING" id="1450535.A0A317WMB3"/>
    <dbReference type="GeneID" id="37116040"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14348">
        <property type="entry name" value="UBA_p47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000179">
        <property type="entry name" value="Plant UBX domain-containing protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SEP" evidence="9">
        <location>
            <begin position="195"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="8">
        <location>
            <begin position="305"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="258"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY86412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="704" mass="75501" checksum="61C615816841DA3E" modified="2018-10-10" version="1">MEHNAERDEIVSQFCAMTRTNPEEAQGYLAANEWDLEAAVTEFFAEQDEVSEDVSTAGGRRLGDKSESSAGNALGGSSSHSPSTTPQPSSRKSAPKKKFATLGDFASGGGESSEEDDQESQDLFAGGEKSGLAVQNPDDIKKKIIEKAKRNQPRPSEEPTKRSHFTGAARTLGGDDAPSRVIETPSAPSAQLPRRVHRTLHFWSDGFSVDDGPLFNSDDPVNRDILDGIRQGRAPLSIMNVQAGQEVDVEIKQHGEKYVKPKPKYKPFAGAGQRLGSPTPGVKPPAAAAPTPSQSSEPAKPDVDESQPTVTLQIRLGDGTRLTSRFNTSHTIGDVYQFVSAASPSSQSRAWTLMTTFPSKDLSDKSAVLGDMAEFKRGGVVVQRTRDIDRQDASRRSQERRAGGVGKSSVTLQLALSLTLQGKSVGILDIDLTGPSIPRLVGLEDAKITQAPGGWLPVPVHPSTPPSSTSDEPQPPRGSLRCMSLGFLLQSRSDAVIWRGPKKTAMIRQFLSDVLWSDTDYLLIDTPPGTSDEHIALAEQLLTLCTLDTSSSGQGQQPRLAGAVLVTTPQAVATSDVRKEVNFCVKTRIPMLGVVENMSGYTCSCCGEVTNLFSSGGGQVLAEEMGVRFLGKVPVDVGFGELVEGKIGGEEVGDSDDEDGDGEKEKGEEVVDERPLVERYKECWSCKRFEGFAKTLIGEIEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMG8</accession>
    <name>A0A317WMG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP cyclohydrolase 1</fullName>
            <ecNumber evidence="3">3.5.4.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">GTP cyclohydrolase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_556927</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP cyclohydrolase 1 is the first enzyme in the biosynthetic pathway leading to folic acid.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467053.1">
        <property type="nucleotide sequence ID" value="XM_025613903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMG8"/>
    <dbReference type="STRING" id="1450535.A0A317WMG8"/>
    <dbReference type="GeneID" id="37116046"/>
    <dbReference type="OrthoDB" id="4966at2759"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00642">
        <property type="entry name" value="GTP_cyclohydro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.286.10:FF:000003">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1130.10:FF:000012">
        <property type="entry name" value="GTP cyclohydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.286.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00223">
        <property type="entry name" value="FolE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043134">
        <property type="entry name" value="GTP-CH-I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001474">
        <property type="entry name" value="GTP_CycHdrlase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018234">
        <property type="entry name" value="GTP_CycHdrlase_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020602">
        <property type="entry name" value="GTP_CycHdrlase_I_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00063">
        <property type="entry name" value="folE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006825">
        <property type="entry name" value="PRK09347.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006826">
        <property type="entry name" value="PRK09347.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109:SF7">
        <property type="entry name" value="GTP CYCLOHYDROLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11109">
        <property type="entry name" value="GTP CYCLOHYDROLASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01227">
        <property type="entry name" value="GTP_cyclohydroI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00859">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00860">
        <property type="entry name" value="GTP_CYCLOHYDROL_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase I" evidence="13">
        <location>
            <begin position="155"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY86462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="333" mass="36623" checksum="8FEA3490729F643A" modified="2018-10-10" version="1">MGSGTSPPPSGSKPKSAIPSHMLNGSSPLHVSTGSRDARERESLNSSILSSFTPRIPVEFDLPASAAHPSGESLSLMDDTPRGSSSKPTLNDPPRDPRDEAGALTPPATVSRPASPYTLFPPIDFDGLSWPCPGTRARLESTPEETDERIKKLAGAVRTILECVGEDPEREGLRETPERYAKAMLYFTKGYEENVRDLVNGAVFHEDHDELVIVKDIEVFSLCEHHMVPFTGKMHIGYIPDRRVLGLSKLARLAEMFSRRLQVQERLTKQVALAISEVLKPRGVGVVMESSHLCMVMRGVQKTSSTTTTSCMLGCMRSSAKTREEFLTLLHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPR7</accession>
    <name>A0A317WPR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme E2-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_556471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467808.1">
        <property type="nucleotide sequence ID" value="XM_025613869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPR7"/>
    <dbReference type="STRING" id="1450535.A0A317WPR7"/>
    <dbReference type="GeneID" id="37116012"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="42257" checksum="DCECBEC80A255476" modified="2018-10-10" version="1">MDASFHITDLTITLSDTRRSISVSLHNDDPVTLKLPARVTQTSHRILHLHPSTLPQTQPGAKQGQYSFRMQVDETDNDNAALFKVDDTLDGFVPWTATDMSPATRLRCLACGEGVLDEGKVWKDLPSGNWAEMMDFWHCHKPDLPKEAEKSEGDGEDPNALVKGYGAANQVVAMEGSVLVDIPNEDTTPTTTTINCSTCSTQLGIHDPITTGHRLFKTRLSASSTSSTSTSPDEPTTTTTTTWSHHPPETIISAQLLELIERESTRRFILHHDHKTGLLIWIFNPTLHYSNSTPTHSISSQRAMKVFFRDLTEGEIEDMLHPQRGSVSSLAVEEVRLLREEFLGFRDVLRGSNGLLPVEARVFREWRVGLVGRFERNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQC4</accession>
    <name>A0A317WQC4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="16">1.3.8.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">2-methyl branched chain acyl-CoA dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">2-methylbutyryl-coenzyme A dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">BO94DRAFT_565540</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>(2R)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = ethylacryloyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65296"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156439"/>
            <dbReference type="ChEBI" id="CHEBI:156440"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:65297"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>(2S)-2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48256"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:88166"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="25">
            <dbReference type="Rhea" id="RHEA:48257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2-methylbutanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-methylbut-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57336"/>
            <dbReference type="ChEBI" id="CHEBI:57337"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.5"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:43781"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2-methylpropanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = 2-methylpropenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:44180"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62500"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="26">
            <dbReference type="Rhea" id="RHEA:44181"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>butanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:24004"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:24005"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>hexanoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-hexenoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:43464"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:43465"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>valproyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-2-propylpent-2-enoyl-CoA + reduced [electron-transfer flavoprotein]</text>
            <dbReference type="Rhea" id="RHEA:65344"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:156457"/>
            <dbReference type="ChEBI" id="CHEBI:156458"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:65345"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Amino-acid degradation; L-isoleucine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; mitochondrial fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.5" evidence="16"/>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468056.1">
        <property type="nucleotide sequence ID" value="XM_025614501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQC4"/>
    <dbReference type="STRING" id="1450535.A0A317WQC4"/>
    <dbReference type="GeneID" id="37116644"/>
    <dbReference type="OrthoDB" id="10262177at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003853">
        <property type="term" value="F:short-chain 2-methyl fatty acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01158">
        <property type="entry name" value="SCAD_SBCAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase short/branched chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000001">
        <property type="entry name" value="Acyl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF1">
        <property type="entry name" value="SHORT_BRANCHED CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="27">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="30">
        <location>
            <begin position="327"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="29">
        <location>
            <begin position="442"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="28">
        <location>
            <begin position="549"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00051903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="PWY88694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="704" mass="78277" checksum="E74CA19AD30B1B80" modified="2018-10-10" version="1">MARFQIVSDLHLENPVAYDLFEISPKAPYLALLGDIGNVRDDGFLPFIEDQLRKFEVVFLVLGNHEPFHSSWPEVREKLRQFSDDISHKRAQHTQPGSPKLGEFVLLDQTRYDLAPDVTVLGCTFHTKICEMQEERVSFGLNDFYYIKDWSVEDHRAVHEADRAWLNDQVSEIAKSDPHHKIVIFSHHSPTVAPSAVDPVHAKSPISSAFATDLTGEPCWEKPQVRLWAFGHTHYNCDFTDNRTGKRIVANQRGYYFSQAKFFHFIMASITRALRPLSRTATSARLIARPPQPYRLALSSTHAFSTTSRRRDVDLSGLTPTPITFLSETESLMAESVSKFAQDQIAPKVRDMDEAETMDPAVVEHLFEQGLMSIEIPEEYGGAGMNFTAAIVAIEELARVDPSVSVLVDVHNTLVNTAIMKYGDAQARRTWLPKLATGTVGSFCLSEPASGSDAFALQTKAEKTADGYKINGSKMWITNSMEAGVFIVFANLDPSQGYRGITAFIFEKDTPGFSIAKKEKKLGIRASSTCVLNFDDVVIPKSNLLGEEGQGYKYAISVLNEGRIGIAAQMTGLALGAWENAARYVWNDRRQFGQLIGNFQGMQHQIAQAYTEIAAARALVYNAARKKEAGQDFVQDAAMAKLYASQVAGRVSGSAVEWMGGMGFVREGIAEKMFRDSKIGAIYEGTSNIQLQTIAKLLQKQYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQN2</accession>
    <name>A0A317WQN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor rosa-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_464696</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468176.1">
        <property type="nucleotide sequence ID" value="XM_025608078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQN2"/>
    <dbReference type="STRING" id="1450535.A0A317WQN2"/>
    <dbReference type="GeneID" id="37110221"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="573" mass="63895" checksum="3A090D7CC438F811" modified="2018-10-10" version="1">MAGPGGGPPRKSHTKSRFGCKTCKRRHIRCDETFPQCRNCTKHNCRCDYMDVATVHDDASSIRNVPDLLMSAEIEMEVKNWHFTGIAPFAELMQFPRTSWTKLSRADLRLIHHIIGLSIDLQRRGFSSCTIWAQKMPTFLAIALSNDFVMSAILTMSASHLAWITRNQETKQLAYHHRGVAIQGLHNALGAFSRDNCDAILAASIILSWQASEWQSWASLQQGLTTVLSSMHPLWKQESELAMFLENQRYLGCTNTPVMSGYQFQDEDLASLDQTIVALQHLQKRVTHHHEHYRRIGDLLEFVRHFQRDLLSQTPEQAFERMQPLRQWLFWLPPAMLRPEDADIGSLAVLAQFFGVGVVLDSLFPDLGGAYLGPLSIGPIEEIYRIVVARSTADPFHPDSQLALSAMDLPRHTVARYKSRLQWSPRTSLDHYSPAPPSPYHSLHDYRLASSSSPSSASATYAPYTPPLQSPPEVTIASPPFDVSGAYVTAPASQALYPTSPRLLSDPRDDLSDYSHAGSLQHSPGFPPPYMGDVVCGGVPRMNSGGLGLNVQLYEDPPVVVGGYQTGAERGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRI6</accession>
    <name>A0A317WRI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_58303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467695.1">
        <property type="nucleotide sequence ID" value="XM_025615526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRI6"/>
    <dbReference type="GeneID" id="37117669"/>
    <dbReference type="OrthoDB" id="10336687at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="104" mass="11328" checksum="5BC6CF6ABA1D1EAD" modified="2018-10-10" version="1">MGSTIASQDGADPPRKPVVSHFALRFFRPCQPLEGPPLHSGRVWGITHRPVANRKVRPALASNEDHPSAVAPGAPSMRRKVRGSISHSGTLLLCIHQRSTDTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRQ8</accession>
    <name>A0A317WRQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467775.1">
        <property type="nucleotide sequence ID" value="XM_025611673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRQ8"/>
    <dbReference type="STRING" id="1450535.A0A317WRQ8"/>
    <dbReference type="GeneID" id="37113816"/>
    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18066" checksum="812BFB586FE90C09" modified="2018-10-10" version="1">MSVVLDEEPKPKPSRKRQKSADAPSKKTKKQTTAKGKDADIDPNQAEIKRLQGWLLKCGIRKMWARELAPYSTPKAKINHLKGMLKEAGMEGRYSVDKANRIREERELKTDLEMVQEGAKRWGKEDASENSDDSRPKRRLNRGRKSLAFLESEGEETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSX3</accession>
    <name>A0A317WSX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_534211</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468350.1">
        <property type="nucleotide sequence ID" value="XM_025611489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSX3"/>
    <dbReference type="STRING" id="1450535.A0A317WSX3"/>
    <dbReference type="GeneID" id="37113632"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="58"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="247"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="356"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="581"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="589"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY89439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="621" mass="69222" checksum="927798ADADE9EC71" modified="2018-10-10" version="1">MKRKLDANDVPSPEAVEGKETADTNEADFESLNLDPRLRQALIKEKFTKPTPVQAKAIPLALAGKDILARAKTGSGKTAAYVLPILQTILQKKADDPSLKATTGLILVPTRELAEQVQKVVTTFAAFCGKDVRSVNLTQKVSDAVQRTMLADYPDVVISTPARVIANLGNSSLSLENLTHLVIDEADLVLSYGYDEDINALSKAIPRGVQTFLMSATLTSEVDTLKGLFCRSPVVLKLEDKEEKGAGVSQFVVRCAEDEKFLLTYVIFKLQLIKGKVIIFVGDVDRCYRLKLFLEQFGLKSCVLNSELPVNSRIHVVEEFNKGVYDIIIAADDQEVLGTKSSKKAKAAEEVEDDAEEAAGLMGSSEDEEEVEEEKSKSNRSEKRRKLSAKQKDYGISRGIDFQNVACVLNFDLPTNSKSYTHRIGRTGRGGKTGMALSFVVPADQYGKHKPTSFPTAKHDEAVLAKIVKRQSKLGHEVKPYHFEMSQVDAFRYRMTDGLRAITRLAVQEARAREIRQELIKSEKLKRHFEDNPDELRQLRHDGELRSARIQPHLKHIPEYLMPSKGRKGISSENVGYVGFRKSSDNRIRKARDKNRAKGKGRKPSGVRKADPLKTFNRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WU78</accession>
    <name>A0A317WU78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sporulation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_490220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468292.1">
        <property type="nucleotide sequence ID" value="XM_025609114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WU78"/>
    <dbReference type="STRING" id="1450535.A0A317WU78"/>
    <dbReference type="GeneID" id="37111257"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000032">
        <property type="entry name" value="CTD kinase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="4"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="240" mass="27329" checksum="A9543D6B46012284" modified="2018-10-10" version="1">MMADPFEVRMRFTSQLQHLNASVTSSQKAAHYALKYRDMDEDLHSCILEQLERNNINNRANIMYFIEQFCDMATKEDHAPYVRMIQRDILRIVDSVAPPDGSGAANVKHVRRVLNGLQSKEILSPETIAEIDAGLKDRETHPAHLDLEAEDGAEGGTRSKTGTPRGSKGNGMRVDKRQIEQRIEEDRERNKRLRESMWTVSGDDGDEHGKFWDEASDIGEDDFLAANEELTERNQMVTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW48</accession>
    <name>A0A317WW48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_565329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468453.1">
        <property type="nucleotide sequence ID" value="XM_025614489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW48"/>
    <dbReference type="STRING" id="1450535.A0A317WW48"/>
    <dbReference type="GeneID" id="37116632"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="216" mass="24023" checksum="F963EA539B2FF69E" modified="2018-10-10" version="1">MTTPHLKYMRDCLNLASQAPALPTNFRVGAVLISRHISDPTPNYTSDLVLSTGYTMQHPGNTHAEQCCLANFASQHNVSPDHVAEVLASDPDRKLVMYVTMEPCGKRLSGNLPCVERIIRTRGGKKGIEKVYFGVKEPGTFVGESMGVRMLEEAGIEWEVILGVAVAGHEDREGEVERAMQGVETDLDKISEEERRRQEGVKRNPKKRMMEGEVMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW57</accession>
    <name>A0A317WW57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_534325</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468463.1">
        <property type="nucleotide sequence ID" value="XM_025611518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW57"/>
    <dbReference type="GeneID" id="37113661"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY89552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="88" mass="9187" checksum="418E121FA87C9B5A" modified="2018-10-10" version="1">MAPANSGWTCMLPVLPSPPQCLLLRWLTANMATLLPTATTDLQIEPGNCYPDAATPSRERCGLHACPSGYAGGLAQDNLPTCVSLSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ56</accession>
    <name>A0A317WZ56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_573758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469023.1">
        <property type="nucleotide sequence ID" value="XM_025614982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ56"/>
    <dbReference type="GeneID" id="37117125"/>
    <dbReference type="OrthoDB" id="4356690at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016444784" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23834" checksum="4B0102A49A563FC6" modified="2018-10-10" version="1">MVKLQILLNALLCAIANALATNITFAKNFATEQLNLESPYFDLSHFGYYGGQLPKVYGLNQSSQGVEYLAEESYTEFQKIMSGTNNASAEFLAQQESLWSSMKRSTTNSISMLLRNAAGEGNAYAITADHTVCHTGSEAPWHYVTVYWVKEAYITFWKSTKCNGHKGSFNPVCDYYDDPSEVCVFNFKPQSFRVYSGCHHSYGWGKGCSDHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0P5</accession>
    <name>A0A317X0P5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_533199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469469.1">
        <property type="nucleotide sequence ID" value="XM_025611288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0P5"/>
    <dbReference type="GeneID" id="37113431"/>
    <dbReference type="OrthoDB" id="4472639at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="76" mass="8727" checksum="5BE39FBAFE38848A" modified="2018-10-10" version="1">MAETTLDYNEILIQISVNLTNALNTFGPASPQYQCILQILKQCLRDIEEDKERNRRDLDPVTLSVALEFLEIGERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2S6</accession>
    <name>A0A317X2S6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_383818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469650.1">
        <property type="nucleotide sequence ID" value="XM_025607279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2S6"/>
    <dbReference type="GeneID" id="37109422"/>
    <dbReference type="OrthoDB" id="5422293at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="249" mass="29293" checksum="C29D4CE0EDA0CD7C" modified="2018-10-10" version="1">MPPPRRKKPLSLRIRQWIHRLRTWRSPLNLRGSLTRLRAFEKHPLWALLRLFVPFPSWKFPVSDTVPAMEMIGNEELLLLRHDNMIDLESIPIWRVRDTPLRCVYRMYEAMASGVYEVLGTETEYFWYQKGWSLQSISDPRDDDSVRYAMIACLVEELVVAFNWRLSLGMRRNRKHIIRKTEDDPWPPYTPLVGPTWTDSVPALAVADLDGLPERYISKEGKLVLEEGGLNKIFARRNMITNVGWLYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X467</accession>
    <name>A0A317X467_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alkaline phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_614370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470134.1">
        <property type="nucleotide sequence ID" value="XM_025616734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X467"/>
    <dbReference type="STRING" id="1450535.A0A317X467"/>
    <dbReference type="GeneID" id="37118877"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="559"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="625"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="695"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="728"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="871"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="12">
        <location>
            <begin position="618"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY93373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="899" mass="99681" checksum="5112C5ED5D21F710" modified="2018-10-10" version="1">MAPSSRRWTLPLFFLWILLIHTAGLYLFTKGFLLTRQILDSKSDCSNPPVNLSRISLTTGTANSTCWTTPVFSKAIILLIDALRHDFTTSQPTSLKPYHNALTILHEAAAERPHNALLLPFIADPPTTTLQRLKALTTGTLPTFIEAGSNFAGSAIKEDNLITQLRDAGKTLVHLGDDTWSKLFPDHFDPRLSHPYDSFLVEDLHTVDDGIYKHLFPLLRNKTETWDVIVAHFLGVDHVGHRFGPSHPEMRGKLHQMDDIVREAMREVDDETVLIVMGDHGMDENGNHGGETSDEVRAALWLYTAREVWGVVYSDAEPITGVTRRDTPQVDVVATLALLMGVPIPFNNLGQPIEEAFAGVEGGDWARLVEVNALAAAQMQRFAREYEKYGGEGLGLVEGEIWSEVEVDFGDEVALRELYGRMREYQSRMLEGYRRIWAQFNPLNMVEGVVVLLLGAVALLCFQVDADCAGILRMSAVVAGIVTGVVAGAGHVALAGSFRGSAIDGVTLGTAMGSAVLYIWQVDFRKGFRLKIWDWQAVIFTLLLSIGFASNSYTVWEDRVVLVFLSTFGLSTFGVSSRLRHSRGMHGARSLLFMLLSRVASLSRACREEQLPFCRTSFYRLENSAVWRLSIPVIIAVAVLYTTRMALQGLDVRKVFWFRTCMPAALLFNAVFWTLESANEQGWLVNIFAEDTSKTVRMTVARIVLVIVLVGLATAFTSTSGQRSEKQLIFTTAVLLASILASKPTGGLSMTILYYQLISLRHLVPSKISIKPTIAALLGTLHFFSTGHNATFSSIQWKTAYIPFRDPQYPWSPLLVIVNTFAAPIVAACAVPLHSRDDQSQARLLAVQSTVYTTWAVFTALWACILRRHLMLFAVFCPRFLMAGGLMVIIDGLALLSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4E0</accession>
    <name>A0A317X4E0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S-adenosyl-methionine-sterol-C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_459406</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470204.1">
        <property type="nucleotide sequence ID" value="XM_025607840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4E0"/>
    <dbReference type="STRING" id="1450535.A0A317X4E0"/>
    <dbReference type="GeneID" id="37109983"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF4">
        <property type="entry name" value="S-ADENOSYL-METHIONINE-STEROL-C-METHYLTRANSFERAS (AFU_ORTHOLOGUE AFUA_4G09190)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="387" mass="43407" checksum="0C5A08688E6AE313" modified="2018-10-10" version="1">METQTNVLASRQSGRSSESSSLDVVEKQKLANKEFPSTLPDLDKSASPKRWKTFWKAFRYLRNLTPKQVDDFMASYVIYNLDWSDEKQMVETLGPDYQAKVGDCLKAYYGVLNHLCALGDVEKMYIPPFMSKKATVLENQLLYEESIAQDIGLTAGDHVLDLGCGRGRVAAHMTQYTGAHVTGLNIDPNQIAQARSYNEKLGFSNNSFVVQDFNTLPLPFEDASFDAFYQIQALSLCKDLPTLFREIYRVVKPGAKISLLDWASLPDYDPSNPEHAELMSRVKPLIGAVGTPTPESLEKALTEAGFTVVRSDNASVGGLQAPLIDKVDFYFRSMRQVILGLVKTHVLPRHFKTLINRLCLDGEAFIKMDTMRLVTTSYRIIAQKPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4S9</accession>
    <name>A0A317X4S9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_614984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470385.1">
        <property type="nucleotide sequence ID" value="XM_025616750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4S9"/>
    <dbReference type="STRING" id="1450535.A0A317X4S9"/>
    <dbReference type="GeneID" id="37118893"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="271" mass="30600" checksum="0F21060BAA4063E9" modified="2018-10-10" version="1">MTRVLNAVTLFGAGTQGSRLAYMWSRLGRPVYLVDRTPAQLNLALATVERLRASNPPSEPGQVISLTTDELDKALHNSWLAIECVPEDLDCKRPVMEELDRRSDPETIIASNSSSYFISEICKGLSLRTNDRFVNLHSFWPPETQAIEIMGSSQTRADIIPLLMKETQDHGFQPFHVRKSSTGYTFNRYLANHVVWDSAIHTNHETLLLLEEGIATPEVDNIYKAMDIAGLDEHYAKDWIGIPNEPRKVLREMIERGDLGVKSGNGFFHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4U3</accession>
    <name>A0A317X4U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_564002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470395.1">
        <property type="nucleotide sequence ID" value="XM_025614391.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X4U3"/>
    <dbReference type="GeneID" id="37116534"/>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000007">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000009">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="539"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="688"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="836"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="982"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1131"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1277"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="1426"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1623"/>
            <end position="1642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1623"/>
            <end position="1634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1677" mass="190564" checksum="081A6F90A3C71E17" modified="2018-10-10" version="1">MLNRAIALHAQSVETRPLPASIGFNSCTLESDHFVCVRQKLSEEDKPQVIIINLKNNNEVIKRPINADSAIMHWNRNIIALKAQGRTIQIFDLTAKQKLKSAVMNEDVVYWKWFSEKCLGLVTESSVYHWDVFDPTQSQPIKVFDRLPNLNGCQIINYRVNDDEKWMVVVGISQQQGRVVGSMQLFSKDRGISQFIEGHAATFASIRVEGSPLEHKLFTFAVRTQTGAKLQIAEIDHQEPNPRFQKKAVEVYFPQEAVNDFPVAMQVSRKYDIVYLVTKYGFIHLYDLETGTCIFMNRISSETIFTTAPDSDSAGLVGVNRKGQVLSVSVDEGTIIQYLMENPAMSGLAVKLASKAGLPGADHLYQQQFDNLVAQGNYSEAAKIAANSPRGFLRTPETINRFKSAPQSGQGMSVILQYFGMLLDKGSLNKYESVELVRPVLQQNRKHLLEKWMRENKLEGSEELGDIVRPYDMNLALNIYLQANVSHKVIAGFAETGQFDKILSYSKQVGYQPDYTQLLQHIVRVNPEKGAEFASQLANEESGALIDLERVVDVFLSQNMIQQATSFLLDALKDNKPEHGHLQTRLLEMNLINAPQVADAILGNEIFTHYDRPRISQLCENAGLIQRALENTDDPVAIKRNIVCTDKLSPEWLMSYFGRLSVEQTLDCMDTMLQVNIRQNLQAVIQICTKFSDLLGPARLISLLEKYRTAEGLFFYLGSIVNLSEDPEVHFKYIEAAAAMNQTNEVERICRESNYYNPDKVKNFLKEAKLTEQLPLIIVCDRFNFVHDLVLYLYQNQQYKSIEVYVQRINPSRAPAVVGGLLDVDCEESIIKNLLSTVDPSVIPIDELVSEVESRNRLKLLLPFLEATLATGNQQQAVYNALAKIYIDSNNNPEKFLKENDLYDTLTVGKYCEKRDPNLAYIAYRKGQNDLELINITNENAMYRAQARYLVERADSEIWSFVLSENNQHRRSLVDQVIATAVPESTEPDKVSVAVKAFLEADLPGELIELLEKIILEPSPFSDNGSLQNLLMLTAAKADKGRLMDYIHQLNEFSPDEISEMCISVGLYEEAFEIYKKVNNFIAAVNVLVENIVSIDRAQEFAERVELPEVWSKVAKAQLDGLRVSDSIESYIRAGDPSNYNEVIETATHAGKDDDLVKYLKMARKTLREPAIDTGLAFCYARLDQLSELEDFLRTTNVADIEASGDKAYEEGFHQAAKIFYTSISNWAKLATTLVHLEDYQAAVECARKANSVKVWKQVNEACVSKKEFRLAQICGLNLIVHAEELQDLVRQYERNGYFDELIAVLEAGLGLERAHMGMFTELGIALSKYHPDRVMEHLKLFWSRINIPKMIRACEDANLWPELVFLYCHYDEWDNAALAMMERAADAWEHHSFKDIIVKVANLEIYYRALNFYLQEQPLLLTDLLQVLTSRIDVNRVVRIFQASDNIPLIKPFLLNVQTQNKKAVNDAINDLLIEEEDYKTLRDSVDNYDNFDAVALAQRLEKHDLIFFRQVAANIYRNNKRWEKSIALSKQDKLYKDAIETSAISGKSEIVEDLLRYFVDIGSRECYVGMLYACYDLIRPDVILELSWRHGLHDFTMPFMINFLCEQTRTIEMLKKDNEERKAREVTQKTEEDNTPILGGTRLMLTQGPAAPAPSPMAFGQANGIAPQATGFRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7R8</accession>
    <name>A0A317X7R8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_458187</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471096.1">
        <property type="nucleotide sequence ID" value="XM_025607778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7R8"/>
    <dbReference type="STRING" id="1450535.A0A317X7R8"/>
    <dbReference type="GeneID" id="37109921"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF59">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="26"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="535" mass="59277" checksum="2775BFCE6CBEE07A" modified="2018-10-10" version="1">MGLIAETRKAIQDSPRGVFNWYLLLNTAIFALSGISRGFDEGNIACLVVQSQFRIKFGLDQQSPEQYANTKGWIVSIFTAGMALGCLACLPFNDRIGRRWTMRLSTLVYVGGILGQGLCNGNLAGLYVSRLISGLGVGGMTVTPPMYISEIAPKTIRGLLALQYTACQQLGVVFGFFINYSITKTYDGTDMQWMFPTLIQLLPAAIWGLGMLTCEESPRWLLYVGRRTQAVLVLARLRHLPRNHPTVVTEIAVMEYQILQEREAVTDASQWRLLKETFVPVENRRRFFLVFMAHLFSQWSGGNAITQYLPTILGYLGTSGDTASLTTGIYAAVKFACVLVFSLVIVDFVGRRRSLMAGITLQITTLAYLACYLGITRGMTTTALLHAPSASRASTGAIAAIFLHGVGWVIGWFSMPFLIGAEIFPIRIRSLAVSMGMACHWLFAFGCSRATPDLLEVTHEWGAFAFFACICLVSLVYVFFAMPDTTGRSLEALDGLFQRPWYTVYQVAYAKEEDEELEVQAIHERGKSEMVGEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X826</accession>
    <name>A0A317X826_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_349424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470458.1">
        <property type="nucleotide sequence ID" value="XM_025607092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X826"/>
    <dbReference type="GeneID" id="37109235"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18982" checksum="BC69C3B868329CD9" modified="2018-10-10" version="1">MSVKHKIKRSIIVRDSQYHYNKRIASSLRSDHPTPNVPQTECLPHTAEIYPAQQCLPFTLHDIVAFHNNHHHHHHHPKATTFNSTQRSTPISPVLHTEQKILPVTESHIHSMHQPKQSNPGTPHQVIIQSIRRLQKGSARDWLVTDGPGRTYAVTCPCWDVVHGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8G8</accession>
    <name>A0A317X8G8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase I-specific transcription initiation factor RRN3 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_530788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471654.1">
        <property type="nucleotide sequence ID" value="XM_025610751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8G8"/>
    <dbReference type="STRING" id="1450535.A0A317X8G8"/>
    <dbReference type="GeneID" id="37112894"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="709" mass="79705" checksum="10D2DB5626160F8E" modified="2018-10-10" version="1">MGVLATASRTATFAPRPTNPSKMLVTSSPVSILKTPKSTPSSTGIKHRMIMGDDYSDLSLSPSSSSDVETSPSPRKRTRVKFDEEVFMVPYQEETQQERKPEKSAAVVREEVRRAIQRHVSGTDSEAYDRIKEIFAVDPRRRDEDNMFAYDVPTHTSLRHHLLGLLSNVASLDRSCNGLVHAVLNSVWLGRDESYIKLYIRFLGNLAAAQGSYLGSVLRMLVNYLGELPKDTGKVPGYPHVHVPELYARVHMALRHVMQLIPSGSGTLSPLLSGQFPFASDSAKANIAYTRNLIRVISYAPELQGDILAVITEKLVKIDVHIQVDLEDIEEEVGEDVLQGVSPESVMIEEDDSEDDDDNDSVLSDDSIDSESKRIKIVRDNILKLDGMIDTMFEYYAPPFTSGSLDDKENAFDLLLSHFQNIILPTYRSRHSQFLLFHFSQSSPILVDRFAAMCTELIFNKAQPAIMRQSAAAYLASFVARGAHISGEVVRDVFDLLGTYLNSLRLDYEATCRGPDLRRYGPFYSTAQALLYIFCFRWRDLTTAALEGDTPEQVDELEPEDIIFPPSVKEVLHQAIHSKLNPLKVCSPAIVSQFARMSQHFNLMYVFSILETNKRLRMSSFRSIGAMADPRFSQVEREIRAGDDLGYQLDAYFPFDPYQLPRSRRWVESDYVHWRGIPGLDGGDDSDSDADGDESDEELSDGTETDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X910</accession>
    <name>A0A317X910_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_532333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470159.1">
        <property type="nucleotide sequence ID" value="XM_025611099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X910"/>
    <dbReference type="GeneID" id="37113242"/>
    <dbReference type="OrthoDB" id="5342924at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="766" mass="84021" checksum="0E0AFC1D0E5C3781" modified="2018-10-10" version="1">MARARDRLRWQQIQSQRRNSGLGDHFLALLKNLGITSFYNTCCKIRGIEVTERPKVFMYRSKTLASIRCVLHVVPVGAAFGLLILNSAGYYIGGELSGASGQDTEKLAALTFAAKLHELLMLASLGSILITYIRRELAFGEGLPFGAIFTSLQFQDISFLWSLSMWGSIQHDWQRRSTKWFILSLMVICTLLGLTAGPSTSNLMKPRLGDWPAGGTQFWIDCTEDVLFPRTMENSSSLSHCALDNSDLACPAGNWQILNQDYYSFFPRLVDAGSVPQNITVSGPASIRTFGMRSRNIFDSHEMMWGNAYTIATTPLSVVADSVAELGRLWSYAAANIDVGRFKFRNDALFMVNSLQPVVLTFCGQTFYDFSDNITLSFPALGTASLSGGPGTADTSQASINLYDGYSNEAIQDSVVSLLQESSAPSVLWVDDPDLLQPLDATLAAILTLPGTDSSRPQYFTCSVDSRFTNVTLISTRNAIKIVAGQPVDMDKNGTFHADWPRVALTADWARYLTPVIPGTNETILSPITSMAGIFNSPIPSASYYHDIIVENILATLVTNGIGRSAYNHSIIMDLKGAVDPNDLWRGGDWIYDIIPKDGKMGKGRNAFNISAALRNRSTDLVMTAYVNGYAYSAAGITSVLEMIVLAVYIAVAIAHVCYSVYSGLSSSSWGSAPEIAVLAWNSVPTERMANTGAGISTVDIYKNNIRVMHRGNKLEIVTRGNEKPEKRTHLFQQGTNSDRLRTDTDFNLDSTHGQMDPVEENQVYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9S4</accession>
    <name>A0A317X9S4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_460906</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470081.1">
        <property type="nucleotide sequence ID" value="XM_025607904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9S4"/>
    <dbReference type="STRING" id="1450535.A0A317X9S4"/>
    <dbReference type="GeneID" id="37110047"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="49"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="954"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="671"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="736"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="738"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="739"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="896"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY93320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="985" mass="106786" checksum="3D293C39D71B3472" modified="2018-10-10" version="1">MDPADDYLPKTPSVDDLKPNSFHDENFVAVEGLDDSIETTNPGKAVWLIACTVSMGGFLFGYDTGVISAVLVSLGTDLGQALSSNNQELITSITSGGALIGAVLAGMTSDKYGRKLAIYIGCAVFFVGTALQATAFSLAQMVVGRMVVGFGVGEASMIVPLYIGEMAPARFRGRLIVFDNICVTFGQLIAYALGAAFTDVHQGWRYTIAIGAIPAIALAATMPLCPETPRQLIARSHDDEAKKVLRKIFPQATDQQVIAKVRVIRHSIEETTASMSDNSLWWQAKQLFTVGANLRALVTACSIMAVSQLGGFNTLMYYSATLFSLVGFNQATAVSIVVGATNFVFGFPNFAFIDRFGRRSMLLVTVLGMSLSLVVVAITFHWIPVESDLSDTGPREMTWASILLLIALIVYIAFYSAGVAPISWVGTEFLPLEVRALGTMVNTVTCWGCNIIISSTFLSMMKAMTPSGAFGFYAGICFLGWIFVIFCYAEVHNMPLESVREIYTHGFGHILGTRKMVPSERTGEWIVRVNRFLSQSLAQSRYQYTTTQLHFLTPPPYSNFYSPPQHLTGAGSGVQIGSGPNLSRGNWELGGKKKTIHAITMILSTFDKELQVACLAVQRASIVTKTVLTEVDKGSTEKADASPVTIADFASQAILISAIRHNFPADKFVGEESASALRSDPVLADRVWQLVATTKLHDTESEELVAAPSSLEEMLSIIDIGGDGKGASHGRTWFLDPIDGTASFIRGRQYGVSVALVEGGEQKVGVVGYPNFHFQSPVVHEDIVDQDGYGIMLSAVRGLGAYKRPMSKERLQPAVRVCNVLARTNVGQPDLVFAESMESPYINQRLHDIVRKRLDVTKPITDLWSMQAKYAALVVGGCNVMVRIPRNPEYRAYAWDHAGGMLIYEESGGMVTDLNGLPFNYGRGRQLADNMGLVATFPEMHSRVLELVRGVSVEGGGRRGGGKRGKRSRGGGKKESRQAGRQAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9Z5</accession>
    <name>A0A317X9Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nuclear pore complex protein An-Mlp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_484525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471233.1">
        <property type="nucleotide sequence ID" value="XM_025608960.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X9Z5"/>
    <dbReference type="GeneID" id="37111103"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057974">
        <property type="entry name" value="NUA/TPR/MLP1-2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012929">
        <property type="entry name" value="Nucleoprot-TPR/MLP1-2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057577">
        <property type="entry name" value="Nucleoprot-TPR/MLP1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898:SF2">
        <property type="entry name" value="NUCLEOPROTEIN TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18898">
        <property type="entry name" value="NUCLEOPROTEIN TPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25481">
        <property type="entry name" value="Nucleoprot-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25785">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07926">
        <property type="entry name" value="TPR_MLP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoprotein TPR/MPL1" evidence="7">
        <location>
            <begin position="186"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="NUA/TPR/MLP1-2-like" evidence="8">
        <location>
            <begin position="486"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoprotein TPR/MLP1-2" evidence="6">
        <location>
            <begin position="1070"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="937"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="995"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1582"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1757"/>
            <end position="2014"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="227"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="308"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="424"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="569"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1316"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1520"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="838"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="853"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="942"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="995"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1610"/>
            <end position="1622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1758"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1858"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1903"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1953"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1993"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="2003"/>
            <end position="2014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2014" mass="224643" checksum="8AB1EC6C2BCA9F9E" modified="2018-10-10" version="1">MVIMAAATIELPFLSSHYAVAESTLSTLAQAPTIELVTQLFEAITKKAREHDELKSDKIRLEVELDNAVRSSDSKIKVLKSSVEKGHAEVEETRKKLHESENARSSLESEISSLKSSSTSSESEVSSLKSRIASLEASNRDTLSLLESKSAAYDKLAEELSTQHKKTIELRRELSTAEQNLQAANSASASAKFREQSLQQDLDLTKKNNEWFETELKTKSAEYLKFRKEKSARISELQRENEEISATVDSLRRSENALKSRLDEVEQRYEEALSSIQQLREEAIQSAEAFRIELDSANRLAQLQSNSAETSKKRAKECQLALDKAREDAAEEISRLRVEVETEHVDKEAAERRVAELELTVSQLESDGFAGRRSMSPALNGGGPSTPMRSSTPVGAFSPRASRGKGGLTLTQMYTEYDKMRTSLAVEQKTNQELRSTLDEMVQDLEASKPEIDELRADHARLENAVVEMSNILETAGKERDDATKEARKWQGQVEGLAREGDILRQQLRDLSSQIKVLVLENAILKEGEGTYDREELEKIARKEIDDSSADLNPTGRFISRNLMTFKDLHELQEQNVTLRRMLRELGDKMEGAEAREQDALRQQEQEELKDLRIRVQTYRDEIANLVAQTKSYVKERDTFRSMLTRRRQTVGDASVFSQSLPLGAAPPVASDEQAKDSPDYADLLRKVQAHFDSFREESATDHSALKQQVNDLSRKNSELMSEISRSSSQLGAATQRAELLQSNFSMLKSENAELQKRYATLFENANRQDIKTQQAAEDLVEMKGLVESLQRENANLKAEKDLWKNIEKRLIEDNETLRNERGRLDSLNANLQTILNEREHTDAESRRRLQGSVESLESELQSTKRKLNDEVEEGKKAALRREYEHEQSQKRIDDLVTSLGSAREELVAAKTTRDHLQSRVDELTVELRSAEERLQVLQSKPSVSAAPAEAPATSEEGQETGLTREQELGIEVSELKRDLDLVKQELQHAEERVEDYKAISQQSEERLQSMTETQEQYREETDSLIEEKDKKIQDLEQRIEEISSELSTTNSELTKLRDEHGEAGRRLEEQKATLDAEMTRLKDENERQIAASQFHQEDLKAQAEIAQHAQQNYESELVKHAEAAKNLQLVRSEANQLKLEVVELRTQADTYKKDLSQKEESWNELKERYEGELGELQKRREEVLHQNSLLHTQLENISNQISALQRDRANIPEGDEDGETGAPNLEGLQEVIKFLRREKEIVDVQYHLSTQESKRLRQQLEYTQTQLDEARLKLEQQRRAAADSEHSALNHNKLMDTLNELNLFRESSVTLRNQVKQAETSLAEKSSRIDKLVEQIQPLETRIRELENVVETKDGELKLLQDDRDRWQQRTQNILQKYDRVDPAEMEGLKENLATLEKERDEAIAARDTLQVQAAAFPEQLKHAEDRVQELRTKLTDQFKARSKELTGRINAKQVELNTVIQEKEVIQEELKTTREELNDLKAKMAEKPAAPAPVVEATTGVDSTPASQFPAPTTQLPVAADDQRVKALEEKVHRLEAALAEKDAVLASKDAEHETKLKERSDRMKEMFNNKLAEVRATHRQEMERIKSSQQAAPQEPGTPAPKTEQVPATPATPAAPATPSKEVGLPELTDAQARELVAKNETIRNIIRSNIRTQVAKQKESDKQETQASQEAIVVLEQKFNVEREALKKAHDEGMDEKIKAAVELSDKKSLAKLSMLDTRYRTAQAKIDVVQKAATETPQKPVVEVWEVAKVTRAPPAAQAKPVVASPAPAPSPVANASQPVQHAPAVPSPSPASAATPAATPAATPAAATQAQVPAEPAAGTTAESPATEVEDATALQQPPAEQPATNGPPNPFGQSQNKQPASLPNKPPAGTAPAVLRALSSGLPVARGGRTGGRGGSQQQNPFGQQQPQQQAQGQSQQAQAQQAPSQRGSGLPRGRGGRGGHGRGGNQNVQANAPQQGQASPGRNLNAHARQFVPQGNKRAREDGGEAGGEGGAGGKRMRGGGHARGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA63</accession>
    <name>A0A317XA63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sin3-associated polypeptide Sap18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_562921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472036.1">
        <property type="nucleotide sequence ID" value="XM_025614322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA63"/>
    <dbReference type="STRING" id="1450535.A0A317XA63"/>
    <dbReference type="GeneID" id="37116465"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="28619" checksum="BB3CC97EF8052AB0" modified="2018-10-10" version="1">MPPTIDRQSTPPFHLKLFYRLNNYHHLSDFAPQSSSSSFNSNYNGPISGPNAIRARSPLPPPSTTTTGSTLPSHLQIYTWQSCTLRELSQLLTSALPSLLPDPPVGTRLCFRLIYPDTKGAAMMGPDARGRYLAKELGSVVVGPRGSSFEGEEEEKEAGGKGVRIQGHDAERTLQEARFVIGDYVDCAVLPPLEDGSVAPPVNAGRGMAMGGGMRAFPGMGPGGGGGRGERIPPGDWRRGERLPEGSLGERNGGGGGGGGGRGGGGDGRRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA80</accession>
    <name>A0A317XA80_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_531510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471313.1">
        <property type="nucleotide sequence ID" value="XM_025610913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA80"/>
    <dbReference type="STRING" id="1450535.A0A317XA80"/>
    <dbReference type="GeneID" id="37113056"/>
    <dbReference type="OrthoDB" id="4424523at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="214" mass="24972" checksum="7A1562EAC478BBE2" modified="2018-10-10" version="1">MSTPSTADQVVLDSFEISRLTPVELREETWGWVIYRTTYQSDAAFNRTIDIITFWIKHDVLTNFNYRSAPPSDLAPRHQLWTRHQFTIFEDLTTLDGASIDTVREQFEAWGESLGMRDQWNKYRVCMMIDQEAVDRLSQAVLAEEHNELSVDKCLEDWKRWHVPVIEAFPDLDVGDDYQGWINCSISQLFRLWTLMGDAMSVGRATYMAEDGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA84</accession>
    <name>A0A317XA84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_571063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472235.1">
        <property type="nucleotide sequence ID" value="XM_025614853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA84"/>
    <dbReference type="STRING" id="1450535.A0A317XA84"/>
    <dbReference type="GeneID" id="37116996"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14502">
        <property type="entry name" value="RNA_5'-triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000273">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000090">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF25">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="779"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="236"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="582"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="874" mass="96174" checksum="BFE45333D1CC62BE" modified="2018-10-10" version="1">MSGCESSPANLRRKKETIADPPRSCPRASDRPVVIRHGLPDHSCAYQLPTSAPRSSPPAVTPIKVWVPQSHLLQHKPYSLLQNPAAGGFDRPASLPHYRSGGTPYPPKRCRLLGSCKVRLAFQNGSSLPPINLTFAPGMGSTNVPLTSPTTSRSGPVDISAYLRLWDSVYAAFTNSGAFVSLTRLFQAYSYDGTVNWGKIVFLATCFVTMVGCGVVSSILRRKSWGQASGKARLRRAARKGYSKRSAGTVTSSDEDDYDSTGSLRHGTEGSVSLSEKKEVPQHGQTENDPGLLKKHSSYLSYTTSIATYPSVRTFFRPHPQKDKLPTKPSAIPLLVFVHGLGGSLAQFNHLLTSLSNVGPCFGIDLPGCGLSSFAPTSWDAYTVDALAELLATAIEQHRDKETGQGVVLISHSLGCSLSALLTSSTSTLGANLKEHILGLIAVCPRAAPPSPHEVTKFRRLLHIPSPIFDLWRCWDRRGGLHSTSVNRLVGAAADSDTRGLQVRYNKQSKTDVWRRMAWGTLPSYDRNGRATGGIPGEEVWAGVHTPVLLVAGEADAVAKPAELKKILEFFGRAGRSVDDGADRVSSIPDAPQVHDKAPASYNGRAHEEEFGVEPQVEEEEMADESDMSGTRRSVKTVILPAPASHALIYDRATYRTLAGIIQDFLRQHVDNRLSMGWQLQYLNTSGKWDVKNLAKWKKVAPVSERIADTFAALKMLREVDEEHNPVLFSQKYHDQIYAVIDISYENPVYNPASMEKGGIHYHKHPTVSKIPPTPDEVRDFIALVDRLQNEITEKMEKSGKPEGPRPVVGVHCHYGFNRTGFLIVSYLIERRGFTVSEAIEEFERRRPPGIRHEHFIDTLFVRYCVGLKRAPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAL0</accession>
    <name>A0A317XAL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_572988</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAL0"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="41701" checksum="5836C88E5B3FCF6D" modified="2018-10-10" version="1">MVSFPDLVSVFDPIILTVSSFTCPSFNLGYWSRELPESSVFVFQGLRPCIVQIIGPLHNHDSACKHSSPDDTAADSVPHLRDGLPSQRRQGLATWMDVFDLGGTYQRKVARRDLTSDLLLRCICAFTARQLCLRASGETWAPVATNYYRQSLHLLIQQLNSSEPLRDTLTAVILLGSYEVLAAQGQEHHRHYEGALKLIQIRGISARSVGLDRANFWIWVRHELTIAITNKTPLQLDPSDGNVNWRKGETAEDLAVNWVYKDRTPSEYHELLVGIEIWYTGLFQHLRGVKYGKPVEDGLFKVHFAVLQTGSFTANTCRSLLPLIQDHATEIINISISDIPDQVLCSSILPLYFGCGEQGFPSAQPYLSHTPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAM6</accession>
    <name>A0A317XAM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial protein import protein MAS5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_506773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472404.1">
        <property type="nucleotide sequence ID" value="XM_025609587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAM6"/>
    <dbReference type="STRING" id="1450535.A0A317XAM6"/>
    <dbReference type="GeneID" id="37111730"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000048">
        <property type="entry name" value="DnaJ family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000024">
        <property type="entry name" value="Mitochondrial protein import protein MAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="9">
        <location>
            <begin position="133"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="133"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="356"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="413" mass="45369" checksum="3B7ED14E570FF353" modified="2018-10-10" version="1">MVKETKFYDILGVAPTATEAQLKTAYKKGALKYHPDKNTNNPEAAEKFKELSHAYETLSDPQKRGLYDQLGEEGLEHGGAGGGMGAEDLFAQFFGGGGGFGGMFGGGMREQGPKKARTIHHVHKVNLEDIYRGKVSKLALQKSVICSGCDGRGGKDGAVKSCTGCNGSGMKTMMRQMGPMIQRFQTVCPDCNGEGEIIREKDRCKKCNGKKTVVERKVLHVHVDRGVKNGHKIEFRGEGDQMPGVMPGDVVFEIEQKPHARFQRKDDDLFYQAEIDLLTALGGGIINIEHLDDRWLTVNIAPGEVITPGAIKVIKGQGMPSYRHHDFGNLYIQFDVKFPEKDQLKNLELLEQVLPTRAEQSQPPQDAMIEDFELEDVDSSDYSQARAHGAAGSMDEDDDDVPPGAERVQCASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB72</accession>
    <name>A0A317XB72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_459581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470551.1">
        <property type="nucleotide sequence ID" value="XM_025607848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB72"/>
    <dbReference type="STRING" id="1450535.A0A317XB72"/>
    <dbReference type="GeneID" id="37109991"/>
    <dbReference type="OrthoDB" id="197400at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040424">
        <property type="entry name" value="Smn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267:SF1">
        <property type="entry name" value="SURVIVAL MOTOR NEURON PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39267">
        <property type="entry name" value="SURVIVAL MOTOR NEURON-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20635">
        <property type="entry name" value="SMN_YG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="179" mass="19441" checksum="ACF7419C955FEAB1" modified="2018-10-10" version="1">MGKSTNANKPLTQEEIWDDSALVQSWDEAVEEYKLYHSIHAKGENVEDVLREAEDAEKAPAVQDEQPLDESADHMDADADVPVVNTAANTTAPAQTQQVPQVATSQATNGPDRPPGRSDHETEQTAGPGSIGAASMPHPALSQVQDEGLKNLMMAWYYAGYYTGLYEGQQRANQNKSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB84</accession>
    <name>A0A317XB84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_139966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472655.1">
        <property type="nucleotide sequence ID" value="XM_025605720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB84"/>
    <dbReference type="STRING" id="1450535.A0A317XB84"/>
    <dbReference type="GeneID" id="37107863"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY95894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="434" mass="47493" checksum="0D73DAD9CDEE6BD7" modified="2018-10-10" version="1">MSAQSPQVRQPPATPTYILRGHAAAIHALQIFHQNLRLVSGDADGWIVVWDLVFKRPLAVWKAHDGAVLEVKGFSFRNGAVTEVFTHGRDHKLRAWRFSIQDEEILQKTLPVDYTPTSSAAPQPWLVHSLPVNALNFCAFSMVFLPPSKSDTESGTPEAPSESKSLSSALIAVPNALDSGAIDLFHLPQERRICTIPADMETKTGMVMAANLVLSASGELYVASAYEDGHVMVLGCRGPLYEKDLAKNAKTSWKWEKLYVCRAHSQPALSIHVSPAGDYFFSSSADAVLAKHPIPVLGAAGYREETPIKSINTKHAGQQGVRIRSDGKIFATAGWDSRVRVYSCKTMKELAVLKWHKDGCYAVGFADVAGLESEASTGETTTPQGGDDKVDTQLTTRAEFSLATVHRQRNQKVQNTHWLAAGSKDGKISLWDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBL4</accession>
    <name>A0A317XBL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_507427</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472727.1">
        <property type="nucleotide sequence ID" value="XM_025609611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBL4"/>
    <dbReference type="STRING" id="1450535.A0A317XBL4"/>
    <dbReference type="GeneID" id="37111754"/>
    <dbReference type="OrthoDB" id="2349068at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF34">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="372" mass="39373" checksum="D98966823241C7FD" modified="2018-10-10" version="1">MSNKPPFQKTYPWTSAPIIAQAPMLNIAGPELATAVSAAGGIGFVAGGNDVSNLERKFQRAEQLIKDYKAAAAAEGNLPTNNSLQFYNGPNLPIGVGFLNWGADIKTALPLIIRYRPCAVWLFAPPNCAADQVPWVEGIRAQTSGSVAIWAQVGSVEDAVDAVAKLHPDVLVVQGSDGGGHGLEKSASIVSLVPEVIDKLCEDGQGNMERLPRIVAAGGLVDGRGVAAALVLGAEAVVMGTRFLASSEAGIQRGYQEAILEASDGGVCTIRSTVYDRVRGFRSWPGKYSPRGIVNRTHTELVAGKVSERENYDLYQKALEQESPGYGANGRLATFAGTAVGLVREVLPAGEIVRGVRKETEAVLRVDRVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBL7</accession>
    <name>A0A317XBL7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_458582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471119.1">
        <property type="nucleotide sequence ID" value="XM_025607804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBL7"/>
    <dbReference type="STRING" id="1450535.A0A317XBL7"/>
    <dbReference type="GeneID" id="37109947"/>
    <dbReference type="OrthoDB" id="5346581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="215" mass="24789" checksum="CA74BD9AF5E141DB" modified="2018-10-10" version="1" fragment="single">RSCLRQIILNLSATPLIEDTLAQIVDGLPTRHVSERDRRFYEPDLNTHLQVSLHVREQVRAWRDTFAPDVVEIDFDVAQAYQNSVLGTRSFRLRFIEITAMVIHVAPWPRTCSASPIRLPTNRAFDPIPTHLYHTRFVDHDQYPLGVVDVAGSWAEYQLFGGVVLFDREDSESELRDVFFHQDAYFIVFQLSEPQINYFVAFGLPMARPPHVPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBQ8</accession>
    <name>A0A317XBQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_581132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472744.1">
        <property type="nucleotide sequence ID" value="XM_025615375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBQ8"/>
    <dbReference type="GeneID" id="37117518"/>
    <dbReference type="OrthoDB" id="4508584at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="362" mass="40940" checksum="3FD6DE771F5FA016" modified="2018-10-10" version="1">MTDPQSSERRKTGMLRPVVSGRKKAYPKSEPNRKKRATTIEALVAENQLLADGTDTGGSYFAESTPIVLHNPFSLNSTQLKDPRYSLMVEPIVLSANSSPVPGRYGIGKNYSIPYSPNRRSQRIANQGGSPNYARIAFPMRRFRVAAPRVGEKPAKAPIQPTPSTLPQTPAVVQNTDLPPVWLSEQQIASFWNQCLRDYLSYGEATDKAHAYNLRIRSDNLVTEQQASPIAQCRKFGTADDIGFFKLQFRDLSTVADLDCWKLGEVLLIKRLPAAYQYKSDGTAKAIHGAVVVGEYIRFYKSLEVGKVSIIEFENHQDTLHMEANYLTITEHLTAIRQEWTREKAEPEPEEWMTWINEDYWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC44</accession>
    <name>A0A317XC44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitroreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_531502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471299.1">
        <property type="nucleotide sequence ID" value="XM_025610910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC44"/>
    <dbReference type="STRING" id="1450535.A0A317XC44"/>
    <dbReference type="GeneID" id="37113053"/>
    <dbReference type="OrthoDB" id="2138173at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF4">
        <property type="entry name" value="NITROREDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G03530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="208" mass="23325" checksum="76800577384B9057" modified="2018-10-10" version="1" fragment="single">MPTPTTDSWLEAAASRRSVHNLASTSKVSDARVQEIISKVLSFAPSSYNTQPVRISLAFGEKHKQLWDIILQQAEPILTSINPELWEKLGPMFRGHWGAYGSVLFWERTQTTKEAAETHKATGHMFGEWGDHAQGIHQILVWTALELEGVGANLQHMNVMPPLEAAIKKWAGVPEDYKLKGHLNYGDERAERPEVPGKLPIEETLRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCI2</accession>
    <name>A0A317XCI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_601204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472796.1">
        <property type="nucleotide sequence ID" value="XM_025616372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCI2"/>
    <dbReference type="STRING" id="1450535.A0A317XCI2"/>
    <dbReference type="GeneID" id="37118515"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF26">
        <property type="entry name" value="FAD-BINDING 8 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="200"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY96035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="460" mass="52536" checksum="366EF9AE1A74E524" modified="2018-10-10" version="1">MLLYLSWRIFLNCYFTYIRPWWLVHVAYSSLRPTFWDIKIILKPQFLGPIAYFAGTAVFNIIGVNSISEAGIRAARLSIFTLLLLFWAGDHEYGARLLGVSLGTYQYIHRISAIMAVLQGTIHVVIKGQEMHFSASNTVQFYGLMVRSMFLVLLLFPLVKRRVYEIFLKIHQGCAIFTLYSIWRHVNASYTRYWVYLLTATFTTTAILQVSRIIFRNISRGKKSTRFVTQSCGDGMIRVTLLLPRPWTIRAGERVNINIPGLGFRYTFQSHPFSIAWWEEDTSGRVQSISLLIRARSGFTRKLIDYSTSSIQQRAWIDGPFGPSSVSSIGPLGVGDYSHVFMVTTGIGIAAQLPYIKELLSETRKGRTRTRKISLVWQLQREGDWEGARDWLQDLVEQDNGCMLNVTIYDQLESPSKVPHTVGHHELITTYCGNVDWKEQLLNELEHQVGQLLVAGTVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD41</accession>
    <name>A0A317XD41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">1-acyl dihydroxyacetone phosphate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_529909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473295.1">
        <property type="nucleotide sequence ID" value="XM_025610551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD41"/>
    <dbReference type="STRING" id="1450535.A0A317XD41"/>
    <dbReference type="GeneID" id="37112694"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF15">
        <property type="entry name" value="CHAIN DEHYDROGENASE_REDUCTASE (AYR1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="288" mass="31865" checksum="E0ADB9CD61FA83C4" modified="2018-10-10" version="1">MTQPNSSFALITGCSSGIGKALAVAFAAQGITVLATARRAESLKDLTSSHDNIEAFELDLSIPESIPKLKDAVSERTGGRLDFLVNNAGTHYASTAMDLEVEEVEKLFQVNLFAVMRLCQIFIPLLRNSPRGRIVQLGSVTRNVPMVWQAPYNASKAALSQYSNTLRLEVKPFGIEVVELVTGFVQSNILHHGMYAPEGSLYLPLKKIIEHIKYQGNANGMPADEYARAVVAKLVKPRVGAEIWEGVHARALRLLVAILPLRIFNWFFYRRFKLGLLEGRQGDKNKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD91</accession>
    <name>A0A317XD91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_592285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473260.1">
        <property type="nucleotide sequence ID" value="XM_025616140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD91"/>
    <dbReference type="STRING" id="1450535.A0A317XD91"/>
    <dbReference type="GeneID" id="37118283"/>
    <dbReference type="OrthoDB" id="5404564at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886:SF1">
        <property type="entry name" value="NACHT-NTPASE AND P-LOOP NTPASES N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38886">
        <property type="entry name" value="SESA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="565" mass="63334" checksum="A7687DE3675CC91B" modified="2018-10-10" version="1">MGSPESPLSFLSSRFVYELQRASPTVVMAFLQPSIVDILTLSKMAFDIAQAFTSGRKAAPAEFHEVQNQLYSLGKALDSFKSLAPDTQQQSDQVEGILEIIGNCRFTLEHLQHLVDKYMVIQEGQPQSHRKEWRAEIWRNWKKIRWTREGGDLARLQHNLGVHVNSLNLAVAVMNRHLILAFLANGSIIGFLKSADTLHSVTDEYDRAVRWAADGVETMVVLTRIVDVGLPVAEQRLAILYVSLYCMPLRKLLIDIRRSVERKIESLAVFPSMNPYTGHPVKSVVNMIWHLTSKGTWLYQESAEMILQLMSKDENLGARDDRATELTVTVDQDTDISIAEDSTTLTIAKTSCNLANESGQEELVEAVDVQMMLLDRDSTSPRSCKLSTWATTKVARRCGFVQDTANSEKRNTTIRTNDVVSLTDPCFHRALGHLMVYNYHISDATLKLVSNLERNAYRLLISNTSRSTCLSIDVSAESLKNMDRQNDAYIQIGGPCLVAETARNRANIHQHNSAATLTCADQETQRVLVMMLHSAGRDVNENMVPSIPGHGFSELEMFSEMMDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDK3</accession>
    <name>A0A317XDK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_529961</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473354.1">
        <property type="nucleotide sequence ID" value="XM_025610573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDK3"/>
    <dbReference type="GeneID" id="37112716"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="67" mass="7841" checksum="A97E09DA341C1830" modified="2018-10-10" version="1">MGCLHHHKLSGEWEPLVGGWLDLYYLLFCLLSFFFLPSDNWGVDKEKETDLTHSSGEPKKYHDWASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDT4</accession>
    <name>A0A317XDT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PaxB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_571712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471849.1">
        <property type="nucleotide sequence ID" value="XM_025614884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDT4"/>
    <dbReference type="STRING" id="1450535.A0A317XDT4"/>
    <dbReference type="GeneID" id="37117027"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF2">
        <property type="entry name" value="TERPENE CYCLASE AUSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28101" checksum="D3A3CFF6CC322FA6" modified="2018-10-10" version="1">MDAFDLSTAPPEFQAWGATIFACNAYTNIIWLYVYYGMIYRSYKDKSFSMPLISQCLNIAWELTFGYLCSLDHWLVTLSFQAAFISNCGVIYAAIKYGAEEWDRSPMIQRNLVWLYIGGTLLALAGHLSIVAEIGAIKACFMNAIVCQAILSVGCFCQLLIRESTRGFSLNLWFFRFTGSLTLIPEFYLRGKYWPEAFGYLEQPFMLWCCYIYMGFDLIYPVVFWYIQKREKEGELAKSLKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE01</accession>
    <name>A0A317XE01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_529783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473162.1">
        <property type="nucleotide sequence ID" value="XM_025610526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE01"/>
    <dbReference type="STRING" id="1450535.A0A317XE01"/>
    <dbReference type="GeneID" id="37112669"/>
    <dbReference type="OrthoDB" id="2896006at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="113" mass="12492" checksum="521023905A7F30C3" modified="2018-10-10" version="1">MAIAARLAKTALIYLAPLAPLQDDTIFQWFLYNAAIESSLSILQVALVHIIISQPSRRRFYQHIPTLSSWLGNCPNGCFCGILASANFYFPIFLVRVFGKADGSNPISNEMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE27</accession>
    <name>A0A317XE27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arp2/3 complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_284770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471561.1">
        <property type="nucleotide sequence ID" value="XM_025606653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE27"/>
    <dbReference type="STRING" id="1450535.A0A317XE27"/>
    <dbReference type="GeneID" id="37108796"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="388" mass="43592" checksum="EA28E4B1A451DEEE" modified="2018-10-10" version="1">MADMPIVLDGGTGFLKVGYAAQNFPEHQFPSIVGRPILRTEEQAGDIVVKDIMCGDEAAAARSMLQISYPMENGIVKKWDDMQHLWNYTFYEKMKIDPTGRKILLTEPPMNPLKNREQMAEVMLEGYNFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIIPVYESTVLNHHIRRLDVAGRDVTRNLIALLLRRGYALNRTADFETVRQIKEKLCYVSYDLELDKKLSEDTTVLVESYTLPDGRVIRVGSERFEAPECLFQPHLVDVDQPGMAELLFNTIQGADVDVRSSLYKAIVLSGGSSMYPGLPSRLEKEIKQLWLTRVLQGNPERLGKFKVRIEDPPRRRHMVFLGGAVLANLIADKEDMWVSKQEWQEQGARALAKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF93</accession>
    <name>A0A317XF93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor RfeG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_9513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473188.1">
        <property type="nucleotide sequence ID" value="XM_025617755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF93"/>
    <dbReference type="STRING" id="1450535.A0A317XF93"/>
    <dbReference type="GeneID" id="37119898"/>
    <dbReference type="OrthoDB" id="4146887at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF1">
        <property type="entry name" value="RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31090" checksum="605808F7E8F87EEB" modified="2018-10-10" version="1">MTGRLGFEGRPERQNEYFIPGDGISREVIQADICRYLGNDALVRPGNHNGRQGFFIRAYRNLTSEMIADLKADSARWEADVLRRADQGYPRGSYNQDYSYSQAPNMGSASYPVSAVHEGRQQGGPSPPPAYSAPPPAPQQFVVDPYGQPPYAATQSPPYPPASSYPANHSPYGTAPNPYPPPQIPYTTSSQPAVTAEMHPSSYTYGTGYGYENGRNNAPRYPGPGYEPEPDYSPVTSGIPYPATTAPDPRIGMDPRYTPESTYPPADRNRPQPARGGEAPRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFC6</accession>
    <name>A0A317XFC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein translocase SEC6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_620876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472191.1">
        <property type="nucleotide sequence ID" value="XM_025616962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFC6"/>
    <dbReference type="STRING" id="1450535.A0A317XFC6"/>
    <dbReference type="GeneID" id="37119105"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY95430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="70" mass="7874" checksum="A6407872F73A99FA" modified="2018-10-10" version="1">MSDQVQELLNVPREFLRDGMQFVNRSQKPDKREFIKISQAVGTGFLIMGFIGYIVKLIHIPVNNVLVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFG4</accession>
    <name>A0A317XFG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_530197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472241.1">
        <property type="nucleotide sequence ID" value="XM_025610632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFG4"/>
    <dbReference type="GeneID" id="37112775"/>
    <dbReference type="OrthoDB" id="3359339at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="122" mass="13359" checksum="36BC08094E4E0779" modified="2018-10-10" version="1">MNDYDKVRLAYDAEKDLNSYQAKQGLGPKSDSTLESGVNEMVDRKFETGVRTGREAGASGSNRKPIPEDEGGSRDDRGRLAPAGEYEGPGGPEDKVKIESERRPGDQDTLNLQDMKREGIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XHN1</accession>
    <name>A0A317XHN1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_530099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473491.1">
        <property type="nucleotide sequence ID" value="XM_025610610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XHN1"/>
    <dbReference type="STRING" id="1450535.A0A317XHN1"/>
    <dbReference type="GeneID" id="37112753"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY96730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="492" mass="55609" checksum="3A2E380353BEF205" modified="2018-10-10" version="1">MTFGISLCAAVITALLLPVLGAIRRLYFHPLSRYNGPRLWALTRLPYMFAFRSGQLAHKIKSFHEIYGDTVRVAPNEVSFIDPSAVKDIYNRRPNSHYKSLPKDPVRQPPPRPGQPINILEAGDEDHTRLRKAYAVSFSTQALTAQEPLVTSYVRKMIAQMKSWASSAAIVDLQDWVSYCTFDIICSLSLGEDFGCLDQDRYHEWVGMLVHSLKGKVQLASCRFYPWLFNYLVKRLPKSAMLMAAKHQATTKEKVQKRLHTNVDRPDFLSHLQRSKHELTDGEMEINAATLIFAGSHTLQTGITGILFRLLQNPDALSRVTEEVRSSFATAEDIDYRKLSKLPILEAAIKEGIRLTSPVPLGLTRLVPAGGHTICDEFFPEGTIVSYMQWAANVSPQNYTKPNEFHLDRWLNSNEGPFANDQRSATQPFLQGPRDCIGQNLARMEISLILGHILYNFDLDLPQGNKGLGKWEDQETYAVWLKSPLPVKLTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UQL5</accession>
    <name>A0A317UQL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_480640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000106">
        <property type="protein sequence ID" value="PWY63865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UQL5"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY63865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="157" mass="16311" checksum="9B053106BF1D23A5" modified="2018-10-10" version="1">MAPPAASLRVAGPHPCPFSPAAPLMIQFHPANWQIPFASTHPCAGPGRQPQRSPATAGAGHLPGPRRERRPASRPCPTGPPDPRRLPSCVQTLRCPKVIRGGVVEAHRIPTAVLRGQLASPLQKEEGPRLGACAPSRCPLQPPGAAGLVSGGVVTQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UUC0</accession>
    <name>A0A317UUC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_570351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000057">
        <property type="protein sequence ID" value="PWY65614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461450.1">
        <property type="nucleotide sequence ID" value="XM_025614800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UUC0"/>
    <dbReference type="GeneID" id="37116943"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF281">
        <property type="entry name" value="ASPYRIDONES EFFLUX PROTEIN APDF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="26"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY65614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="416" mass="44580" checksum="E5E96ECF603E9401" modified="2018-10-10" version="1">MSTDTEKNAAIADSPKPPNFPEGGFKAWMAVLACWCVMFNTFGYINAFGIYEAYYKNTFLQNQSESNIAWIGSLQAFFMFSAGLISGPLMDRYGPRAILIPCSLLFTLSVMLNSLCKQYYQFLLAQGILGGLTNGLIYTPTLTAVNQYFFTRRPLAMGIASSGSSLAGIIFPIALNRMLNSSPLGFGWSVRILGFLMLFLNIIACIAISSPAPKRKSGSPFLLEAWSHPAYSFQVAGLFLIIWAIFVPFFYIPSYAQSIGIDINLSNYLISIQNAGSLVGRLLGGILANRIGRFNTLTASSAICGILILSWLAINSLSSMIVFSILFGFFSGTVVGMFPATIAMTAPRPNVIGSYMGMALGVLSLASLTGTPITGAMISSYGDYHAALVFAGVCALVGSGVVFVGRVWGVGWVGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVA6</accession>
    <name>A0A317UVA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_339448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000058">
        <property type="protein sequence ID" value="PWY65366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461432.1">
        <property type="nucleotide sequence ID" value="XM_025607026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVA6"/>
    <dbReference type="STRING" id="1450535.A0A317UVA6"/>
    <dbReference type="GeneID" id="37109169"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="287"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY65366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="703" mass="77973" checksum="B6F8154481096F3C" modified="2018-10-10" version="1">MTEQRASKKKRVDGEKTKYPVLTYVEGRLQSSIRIADLQSLLLYCFADGIAPQWISVKHSGHVRKIVVLMVPGLELGMFDGSVPLDVDAVSDEKAAIGEKEQGKTADGEAMEEDPKAADFARWKQGLPLEDRSHRFNPRPLSHGDLPAPLRPLADIFPHAWPVRAPGDSKYNKIHSPLQAILLSALPKTKDSNTKGAKPPRVDKSLVFQRTPITTFISSVEDLRENDYVLHPALLTSEQEKSALMESRKRAGQSTEDGWVDTHVESLEAGQIPDSEIQQGSMTAGRDVLALDCEMCVTEGGQSELTRISMVRWDGEVVLDELVKPQRPIIDYLTRFSGITKELLDSVTTTLSDIQQKLLSILSPRTILVGHSLNSDLNALKLTHPFIVDTTFIYPHPRGPPLKCSLRWLTQKYMGKEIQKGQTGHDSIEDARAVLELVKQKCEKGERWGTSEASNESIFKRLARSVRSGKSSTSEGRTGAVVDWGNPERGFGSQATVAIGCSDDNDVVKGISSVVNGDASNPSIPGSGVDFTWGRLRELEAYRGWCNRLPDPNNANESTTLVPPPEETTPTSAAVPTSKEATRNLSDSVSRSVSSIHQIYQSLPPCTLFVVYSGTGDPRQVSRLQAMHKTFREEFNSRKPWDELTVKWTDTEEQALKKACERAREGCGFMCVKPGSRYSAWWFRAGALFRNAFRGLFRKFPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYG5</accession>
    <name>A0A317UYG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_570254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461663.1">
        <property type="nucleotide sequence ID" value="XM_025614790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYG5"/>
    <dbReference type="STRING" id="1450535.A0A317UYG5"/>
    <dbReference type="GeneID" id="37116933"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="700" mass="75573" checksum="4B46E58C0318DDBE" modified="2018-10-10" version="1">MAKVDTAGEVDSAPTAASPTPTLPKAPVEARSLSSITAIASNPPAYPRNPTQKKLDPLVLYIVRVPGSRDVFLTPLKPPTKSNVSAEAINASLYYLHVATPDDDVLLQEYEQEHEEEARLRKETLGSDADSILPAREFARLNNVRRKPVPGAGDAASATKVDATVAPARPRPTSWQSQGSLPSSPSLQRPPMPPRPSFQGPPPEYTPSTPPFAPVNRDPFDATAPNDARPSRPLPPVPRDEPVLGPPLDPMPKKANRWSAALSGYIARGQESWRDKIEAGRPSLDSQRPQIRPDIRPHSAHGSPSHSYLGSPSRSPGRGPARSPGQSPSLRPHDRMPDRPGFHLTLIRRDPTHGSQWNVATMSTPRMDGGPIDIEVLTPGYNRFTAQNEPISLASLGVNLPGGQPISLSSFKRPEVTDPPTSTPNEPHPRRFHRKLCVSRPYFQEEPRGSLDLTGRPSLDSIGGGSPTKPHVPSHSKLKSGYYTFNSPWNGICTFTTSVNGRSLKCKHMIPTPGFPSTSHHHTPTSMPEPPAITAAEIRFNTPFRTGHLHQPSGAPYISPSYHPASPPTEFSLSSPTSTSGIPSSKRDSLARFLNAHKYTRPRARSGASISSGDIGTSHHTRNASNSSTSSGGDEEREKSGLLRRPPSDDRLDLSLARERAGGGMRGKSAKMGKLIIEDEGIKMLDLVVAACMAVYTVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYV5</accession>
    <name>A0A317UYV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_478965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461898.1">
        <property type="nucleotide sequence ID" value="XM_025608720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYV5"/>
    <dbReference type="STRING" id="1450535.A0A317UYV5"/>
    <dbReference type="GeneID" id="37110863"/>
    <dbReference type="OrthoDB" id="5337438at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001827">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="174"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="107"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY67254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="543" mass="60429" checksum="31F866289E5F4B4D" modified="2018-10-10" version="1">MATASPAPRTPGRTQPSAEVPPVVTETTKDQRRTSSLGFLRRSKSIEILGERRSSGSKNGKKMPKPQPTEEDTRYQRESMMFQQPPRLPDLSPAPVLETFGGDERQDTVAALSSQPAPSHQQAVPRSAISTPVTPEPNDLYSRAESMTHRGRYSYASSAVSTVNNPRRLRRRKDPTPYNVLVIGASNSGKTSFLNFLKSSLELPPHKHPSRLPEEVAQQARQSPANEGYISHYLETEIDGERVGLTLWDSQGLEKNIVDIQLRGVNGFLESKFEETLSEEMKVVRSPGARDTHIHCTFLILDPVRLDQNIAAAERAAQGTPRATDTPVIGVLDERLDVQVLRTIVGKTTVVPVISKADTITAAHMAYLRKAVWDSLKKANIDPLEILALDDQDEYTSSESDDEENEETQGQDADQQEAGVPRSPSQRSQSTRKSSGSQVVVQHIPFTTLSPDPHSLKAGDEPVGRKFPWGFADPYDPEHCDFLKLKEAVFTEWRADLREASRVVWYERWRTSRLNRNVAAAGSVAPQKKLFAGRTGPDVRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZK8</accession>
    <name>A0A317UZK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_480167</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000058">
        <property type="protein sequence ID" value="PWY65370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461436.1">
        <property type="nucleotide sequence ID" value="XM_025608780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZK8"/>
    <dbReference type="STRING" id="1450535.A0A317UZK8"/>
    <dbReference type="GeneID" id="37110923"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000861">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000065">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000470">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="12">
        <location>
            <begin position="91"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="239"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="715"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="807"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="722"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="9">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY65370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1020" mass="113799" checksum="85B79BD0F16905F9" modified="2018-10-10" version="1">MEATQESTQPCTDPRRMGYNHSGLHDDDMTDIICILHPNSPAAHDAVAATARHRPQHILQKDALEYECSDTAALDFALRLSSNVYDANAGFCFGRNRARCDLLIADANSKRISNTHFRIYLTQDGIIMLEDTSTNGTIVDNCRLRKSQKEKSRMLVNGSVIQVPNGELLGSEEVRFIVRLPSREGFVMQYTENMLHYFEKIETQRAGAVRAKARATPAPALQMASPNTYGMHWSGGLTYNVTGQIGKGAFATVYKLATKQHGAVYAAKELDKRRFMKNGILDKKVDNEMKIMKDLKHPNIVQYVDHHEYDRWIYIIMEYVPGGELSTYLQSHGRIREDMVRPMARQILHALHYLHKRKITHRDIKPDNILIASLDPLKVKLSDFGLSKVVQEETFLRTFCGTLLYCAPEVYPEYDTYRRGEVRKRRRLGDPPPKTSPYDQSVDMWSLGAVLFHLLSGVPPFAPRADDRGAQMLRIIMTEDADYGELRKADVSEDGIDLVARLLNRDPMSRPNERECLRHPWIAGVADTDEYDDDDLALNLANDLSDIGEDLEDEIDASQLSLNDKPAADMAVEEDSEAAQSKKIKLDYPPAEIHYPSLPSVDSFQIVQPVSQSSPKRLFGEITPSVLRSSHALGENVDAYEGDDFSIHDFVSSTGESIISDGNSLNSVLSLPENPVAGSAPSLMGAEKLVGQLNMDSWLPGISSKILHVEAPGPQTSVAADVPDRQSPEAPKHTPTDDTTLKPCIFSRRIELPVPDTASERSSPETTGKSTEKTMEKTNYGRTESEAEPGETFDIELSNTIDAKTGVQLPDLPQRDDNQSPPEPLPHQSPDLNIKIVSPPSKAHPLLGKLTTLPGSIFELTIPLETRMTSWGRGPLATICYPEPMDTRIPAYALEVTFWAPAIETKIAAGQEWMTVPGVMAILSTKTRKCIWVNGTELRRGPDGDNGREGFHFGKLYSGDVITVYQHRHKFLKFTCEFYHGDSARPRPDEEKGFTVRKVLMPKETTANRLPARKVTGGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V118</accession>
    <name>A0A317V118_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_504224</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461680.1">
        <property type="nucleotide sequence ID" value="XM_025609500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V118"/>
    <dbReference type="STRING" id="1450535.A0A317V118"/>
    <dbReference type="GeneID" id="37111643"/>
    <dbReference type="OrthoDB" id="5319341at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY66482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="534" mass="59921" checksum="C6A85ECA566DEFB5" modified="2018-10-10" version="1" fragment="single">MPPSLPSRRPRIRKSRGRGLRTKNGCITCRKRHMKCDEVKPVCGPCTKKDKSCEYHPSGRRSIVAPVSAQEETTTPGIDDSQNDAIPDPVTYEPHEAAGASWNCSDVDVNPPLPVLDHLPGSDLAASQSPITFQHAYLSPSNASFAAVRWFGLLANDAARDSPQLSTAPYPHARESIPLDHYGTDSLNQPRSLQYATQLLDNTLDIDPSHDQTGVTATASSPLEEQLIWQSRESIELLPTEQALFEHFVNQIHNAGLMNAILALAFRHLALNPRLDNQDMPNKGEAALQYYYQTLHYVQRAMRFSSYKTSLELLATALIISAYEMLDNSTNDWERHLEGVFLIQRSQTIHGESGGLHSAVWWAWLCQDIWAAFREKRKTLTFWVPQKPLSALLPHELAMRAIYITAKVISYCADTTDEENLQSRIEEANRLRTMLEDWQQHLTVEFSPLPLGAREQSTYFKPIWIRPAASALAVQFFNASYILLLAHEPSLGGLEQYFQRQSAIKRHVGDICGIAMMLKDSESSLMSSQALFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2D9</accession>
    <name>A0A317V2D9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">1,4-alpha-D-glucan glucanohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_561390</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461634.1">
        <property type="nucleotide sequence ID" value="XM_025614213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2D9"/>
    <dbReference type="STRING" id="1450535.A0A317V2D9"/>
    <dbReference type="GeneID" id="37116356"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016319444" description="alpha-amylase" evidence="19">
        <location>
            <begin position="16"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="20">
        <location>
            <begin position="25"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="503"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="14">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="15">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="42"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="253"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="469"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY66370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="560" mass="60707" checksum="74C938C0054E8F2A" modified="2018-10-10" version="1">MVLLVVAVTVQAASRDQWIGRSVYQIVTDRYARSDNSTTAACDAAQGNYCGGSFQGIINKLDYIQDLGFDAVWISPAQTQVSARTADLSAYHGYWPNDLYSINSHFGTPDDLQALSSALHDRGMYLMLDIVVGDLAWAGNPTTVDYSTFNPFNDQKYFHDFRLLSDDPTNETCVLDCWMGDTIISLPDLRNEDHQVQQMLGTWISELVSNYSVDGLRIDSVLNIAPDFFANFTKAAGVFTLGEGATKSATDNCPLQPSINGLLNYPLYYILTNAFNTTNGNLSTIIQSIDFVKTQCEDVLALGTFTSNQDVPRFGSYTSDISLARNILTVSMLTDGIPILYYGEEQHLSGAFNPVNREALWLTNYSMDSTSLPSLVQSLNRIRSYASGDGKQYTVNSKSGTDYLSYLSLPIFNTSHILATRKGFAGNQVVSVVSNLGAKPATKATTKITLGSDGTGFQSKQNVTEILSCKTYVTDSHGNLTVDLSSDGGPRVYYPTASLKESTDICGDQTNTTTPSSSGASSVSPTPSTGAETSLFGLSLEIRTLLVTVAMATATSYLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4U9</accession>
    <name>A0A317V4U9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_307714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461864.1">
        <property type="nucleotide sequence ID" value="XM_025606804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4U9"/>
    <dbReference type="GeneID" id="37108947"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY67220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="59" mass="6902" checksum="F19FD68CE6DCE361" modified="2018-10-10" version="1">MTRPASSQYALIFPRVARSCLSHSSKSIEYLLAYQEQEKEIIQSTSQMLRKRDGHFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V819</accession>
    <name>A0A317V819_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_268736</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462577.1">
        <property type="nucleotide sequence ID" value="XM_025606539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V819"/>
    <dbReference type="STRING" id="1450535.A0A317V819"/>
    <dbReference type="GeneID" id="37108682"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43495">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43495:SF5">
        <property type="entry name" value="GAMMA-AMINOBUTYRIC ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016333108" description="Amino acid permease/ SLC12A domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="2"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY70286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="530" mass="58896" checksum="85E2B7FE66E3ABA3" modified="2018-10-10" version="1">MGLLLATLIMSVVVVAVNECFAELSQRFPIYNAIAEYVRTFLDEELGWVVGLAYWYAYAAAFATQNMTAGMLLEYWGLSKAWRALICYGLVPIALFLLNAMGVFYYGLVGTFGGCLKLIMIIAISIYLYVIAGDSAVKIPSLSFSHSDEYASKAQAGCYALTIITYAFQGIEIYAMAAYEAWDDNSLGWASQYTVYVVVVVYIMCTVGEVLTVDRNSIFPDLDADRKRGQSSSMVIIAALNAKDKRLAGFLNGCLFFSVLSAANTSLYVASRTLYGMADKMPRNWITRSLSTVSKKNQVPVAALLVSMLSFYWVPFLRLKDCYVAEQITEVISFTCSNAIMIVWAAVCGAFIRYHRWMKHYSEGLPTRQRRTPRGPLASLQPLQAWLGLITCIVVFAFSSAPWWNDNATVGKVAEAYGTHIVSVTLFLLLKVKKAFNSEEKLFIPAANLARLTEELDDLEIRRINHAGTTRLEQWMTGLVGRVRRRSTVNPDDDRGLENTDFHADLLMVQTQPALTSGTLATGVAVEMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VD67</accession>
    <name>A0A317VD67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_253283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463169.1">
        <property type="nucleotide sequence ID" value="XM_025606446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VD67"/>
    <dbReference type="STRING" id="1450535.A0A317VD67"/>
    <dbReference type="GeneID" id="37108589"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="331"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY72216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="748" mass="85887" checksum="BA17FC47C478C1C7" modified="2018-10-10" version="1">MELPHFNGPTHPDLPLRLGYLNGDNSDPHYNNNPALAELNHWDIATNDIDWNLIPPPYPLPDYDNPMKKQKQSSISAVARERDSLHLESASTSASSHSETRHGPVFIDLTEEDALLTQILDIFPDISHQYVEELIDRHRGSHGQPRLIEQGLLKENVVDEIVQQTDYPKQDKVKKRKIAETEEDDKEWMANMPERGGRLYLQLATQLLCKEFLWTPLHHIRQVMNEKKELFSAFLTLHSQEHRHTNEYTRLKAKRTINVRPDDEGPIAENLNQELRAAKKRAEKEDGEWHGFENQSPMADQRIACQAIFRKQKEDQEAEVRNEEEHNRTGNLVECQCCYLDVPANRSLPCEGDYVHFFCFACIRKSAETQIGLMKYQLQCFDTSGCQAKFARARLEEALGSNMMEKLDSLQQQDEIEKAGLDGLEGCPFCDFKAICPPVEEDREFRCRNPACELISCRLCQNESHIPKTCHEAKKERGLPERHLVEEAMSEALIRNCPRCKVKIIKELGCNKMICSKCNCAMCYVCKQDISQEQYNHFGRPPTNCRTHDEPAENRSLKEIEQAQNTTIRTLLAQNPELTEEELRVHNDKEKKSASNLRPNNFPRAELYQNRLWGNAGHPQVAQDPRQRIVNLPTRSGMQRNAQMDLVHDQPFRTMNYPPMPPPLGAGDRLYGQGYNYPEAQLAGNQFGRARENQGNLPVGGFRRDLNPGALPGHAPPADRMRPETQILADYYGFHMRPDNYDGNYPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDQ5</accession>
    <name>A0A317VDQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_246036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463277.1">
        <property type="nucleotide sequence ID" value="XM_025606407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDQ5"/>
    <dbReference type="GeneID" id="37108550"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY72503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="102" mass="11445" checksum="27AB252F03F2F714" modified="2018-10-10" version="1">MLLAKDRNRQEQEGPESTRPGTSHRVIQSIASPGYCALRRSVHNNGSSESEQYGVVYIVILLPPRGSCLFLSLLFSLSSFPLSCDFPIRRRSFVLVVHALFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VET7</accession>
    <name>A0A317VET7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_271161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462681.1">
        <property type="nucleotide sequence ID" value="XM_025606565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VET7"/>
    <dbReference type="STRING" id="1450535.A0A317VET7"/>
    <dbReference type="GeneID" id="37108708"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF22">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE PHMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="36885" checksum="CFFBBF6A2C104A4C" modified="2018-10-10" version="1">MASLLRLLRTQYNPPVDPSGVSFAGKTVLLTGATSGLGFEAAIKLLNLGVESLIIGSRNLQRGQVTKTELEKLTNRPGVIQVWQVELNSFQSVKSFVNRVNNELKQLDIALLNAGLWNRDSGVSAEGWEETLQVNTLSTSLLALLLLPKLRSSSSPSDPAHLTVVSSQQFVRVKAQSLRTKQPLLKHLNSPQFFKGPRQYGISKLLLEYVLKTVAGLIRNENGTLPVIINTVSPGFCVSSLGRKYSRFYERWMAWLAYKLFARTAEQGSRSLVSATYQGVESHGKCWRSDGYLDESVALTTGVEGRQFQAAAWADIMDVLESQSKGLKKSIRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGD1</accession>
    <name>A0A317VGD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">COP9 signalosome subunit 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_245613</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463263.1">
        <property type="nucleotide sequence ID" value="XM_025606403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGD1"/>
    <dbReference type="STRING" id="1450535.A0A317VGD1"/>
    <dbReference type="GeneID" id="37108546"/>
    <dbReference type="OrthoDB" id="5351233at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010387">
        <property type="term" value="P:COP9 signalosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033205">
        <property type="entry name" value="COP9_CSN8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13339:SF0">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="6">
        <location>
            <begin position="50"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY72489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="216" mass="24496" checksum="65E5C5F010419933" modified="2018-10-10" version="1">MDLPPLSQNQLAAVVASAQSPTELYSTLSEYEGEACLLSTKDGEQAGLLSRYYSTFFFSHLLTDQIREARLSTKRMPQVLLESDPSLQNCLNLLRAVWQRKYEQVYKILRERPWSEPLKPLVQSYDAHFQEKTLKEVSRAYEAIRPAAAATYLGLDPTAAEQGDPVTMQKFLACGWTWEDETGLLHPKPIIDDPQKDAQLYNELSEVMALIGNRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGN2</accession>
    <name>A0A317VGN2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_569152</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463121.1">
        <property type="nucleotide sequence ID" value="XM_025614723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGN2"/>
    <dbReference type="STRING" id="1450535.A0A317VGN2"/>
    <dbReference type="GeneID" id="37116866"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Leucine-rich repeat" evidence="2">
        <location>
            <begin position="104"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY72168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="462" mass="52408" checksum="26A43660D8EA2E5C" modified="2018-10-10" version="1">MSLLLPNDILLLVGEYVEDYRDRYNLLFVCRHFHDLFLRLVYQAASLKDCSQTRSFLGALLRRPELARAVRTLDFHDWSTSTPSTHSDEDLAPLIQWAHTLSHTAEEHIKWEQDLRDNVEEAWIALLLPLVSNLRHLQLVYPKQNLYLDRMMQRVVRGEKPFDDQPALRVLREVSLTHLADEDSRGSYQPSQVLPFFQLPSMRTFSADSVIESTRSQEGQSESVQPVEISMPGTSPISEITLNASNGSQGMQSLIASCSSLKSFKYQHSDEHLLAEGFRPSAFLESLAGSKDSLQTLWLDNYGTHLPFTIAGANETHDEWFGPLMEFTSLKEIRIRLPNLLDVRYQYEPSCPLTDVLPSSVESLYVEGCKENSLGMLVAQLKAVLNKRKTQFAGLKRIDIEGFFHDEDDEDASGYQPGGPGEKVIKPRVYETAEPLHRSCAEAGIDLYVRDRACLATMREMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VI93</accession>
    <name>A0A317VI93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MIPC synthase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_476559</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462958.1">
        <property type="nucleotide sequence ID" value="XM_025608609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VI93"/>
    <dbReference type="STRING" id="1450535.A0A317VI93"/>
    <dbReference type="GeneID" id="37110752"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000001">
        <property type="entry name" value="MIPC synthase subunit (SurA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY71560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="42200" checksum="80F057E022AFDC6F" modified="2018-10-10" version="1">MRRGVLIFLIANLIIVTFLVRSVFTLLSLLVEDASADAIHRAELPSPNSSLIEQRPQIIPKIIHQTYKNETIPEVWREAQQSCINLHPDYEYILWTNEKSRDFIASEYPWFLETFDGYKYPIQRADSIRYFVLAHYGGTYIDLDDGCNRRLDPLLAYPAWVRRTVPTGISNDAMGSVPQHPFFLRTIELLQSYDRHWLLPYITVMYSTGPLFLSVIWKEYMQTNPSESGRVRILMRDEYNKYSWSFFTHHVGNSWHGKDARLIFWMGQHWMFLTVCGFFLAAVVGFGLWWLYARLMLLGSKYRYRYSKIPSLVSSSRLSSPTRMSRRMMPTILRRVSFKEDEEAGGVTETSYELYSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJJ8</accession>
    <name>A0A317VJJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_559641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463669.1">
        <property type="nucleotide sequence ID" value="XM_025614085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJJ8"/>
    <dbReference type="STRING" id="1450535.A0A317VJJ8"/>
    <dbReference type="GeneID" id="37116228"/>
    <dbReference type="OrthoDB" id="3918601at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38794:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="3">
        <location>
            <begin position="30"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY74476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="368" mass="40824" checksum="3FC605FFC716DD27" modified="2018-10-10" version="1">MIVVTEVNRSPIIGILAWLLFVISTLAGLARLIVKYVIARRLTMDDILVSVAMGFSLLQTICISIAARNGYGQEERASSSEQLEKALKSVYASEMFYIASLTFAKLSALAFINFLMQRTRKTEWGLIVLISAWGLAAEFAVAFQCHLPRPWGWNEDHCFDRDTWWMVFGAIDILSESALIVVPTMIVLGIQMAVARKAVVIGCFLTRLLNISAIILELVYRQRNRGAADPMLAIWEAAVCAQVVQCLGIIVACVPHLKPFMDGLQSTGLRMYYLPGETSRRGEYGYDSKGATTGHELSGLPNVVNSTTVFAGERQSDWDDTLSQNSQSHIIRETRTWVVEEQYDPDAAVSRIDNDSNGSHGLHESTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VK10</accession>
    <name>A0A317VK10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_524724</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463551.1">
        <property type="nucleotide sequence ID" value="XM_025610285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VK10"/>
    <dbReference type="STRING" id="1450535.A0A317VK10"/>
    <dbReference type="GeneID" id="37112428"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="125"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="320"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="532"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY73799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="560" mass="61445" checksum="C2043507F836358C" modified="2018-10-10" version="1">MSLKWQRLHISNHESAPLLLFRYSVSKDEYQLYITDLTYIWSECLTRQHILRRAAENSTTIDPSEDPEQLTVLLQKIGEGLRNEPGNCTALSHGPGSDSLQLSTSTNLPAPLQPLNWNIYLSKEPQSSSTAQLLLPLLKAETGRESRQRGLIELLNKKDWVLTKLFDKLEAMGIDTSTVFPGITGLRSSHKGSMMSQAAKYIKGVAPFDEQAWLDETNALSLDPGLASTLLAETSGSSIEDNGQQLGHIKPAPEGWWKTLSATNVPTTSKSPKQKEYNQAVDSRPSQDSTHLETTGYGTETEDDEFERQETPPRLKRRPTSKDKSPSARLDEETESDDEDVKGKQSPVKSPAPRENPPAKLSNGLGIIGGRKKQPSAQESPQPSSLSSPDVDTPVLAPKSPPPRPNSEETESEPDEDGQPAPSSPAPSKPQPSVIPQTKRRGLGVIGGRKKEKQALPPLPSLESEPSSKPQTKTRGLGVIGGKKKERQTSPPPPAQSPEPQTTAPKSHSPAPKQPKALLPPPTEQEKEETEQEKADRKRDELKRQLDAKSKAPTKKKRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLU6</accession>
    <name>A0A317VLU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_538890</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463594.1">
        <property type="nucleotide sequence ID" value="XM_025612580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLU6"/>
    <dbReference type="STRING" id="1450535.A0A317VLU6"/>
    <dbReference type="GeneID" id="37114723"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY73842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="188" mass="22255" checksum="A81FC7D807C0CE9A" modified="2018-10-10" version="1">MRVETCHFCSRPVYPSKGIQFVRNDAKAFRFCRSKCHQNFKAKRQPRRVKWTKAGRAAKGKEMIVDSSLVLSQFAKKRNVPVKYDRNLVAATIKAMERVEEIRQRRERVFTKRRLAGKLARDRKREEDRKVVMEGEHLIRKELREREEGQPLVSETTKASRLHGEERLRQKKTRMLVDGTTQEEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VMS6</accession>
    <name>A0A317VMS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463724.1">
        <property type="nucleotide sequence ID" value="XM_025612538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VMS6"/>
    <dbReference type="GeneID" id="37114681"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="52" mass="5606" checksum="74877FAD30E587C5" modified="2018-10-10" version="1">MSGRTKISSGEGLEELSRVPSPLPFEASTAGARGDPRAHWSVRAREARQLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNQ3</accession>
    <name>A0A317VNQ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_473925</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY75994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463991.1">
        <property type="nucleotide sequence ID" value="XM_025608497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNQ3"/>
    <dbReference type="STRING" id="1450535.A0A317VNQ3"/>
    <dbReference type="GeneID" id="37110640"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY75994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="379" mass="41773" checksum="BA87524847CE196F" modified="2018-10-10" version="1">MFPLYLGAGDPRPLLWSRDGSDGSDAAGILTIVGTLTGLSTLVLFLRCYVRGFLLRRFNAEEHIIIAAWLCAIGVLICFVLEAQHGLGRYSKDISDEDNQMLSKLVFCHSIIVMVGLSLVKISLAVFLRRFSQSLLSKALVASMVFLVAFTIACGLTLILQCIPVAAAWDTSLRPHARCFNNDTFTAIGLWNSITNLVTDVIFATLPVPLFIGIQVNWRTKVSLIGVLSLGYLACVASIVKIISQVKVLKEQNMYRHDTFMIWNCAELNVAILAACLPSIKPLLKSILDGTRSLTSGRRNATSYHYNTHGYYVQHSTDIALKSVTRTRPSPYDITHDASVVASSDSDSGSRRESDEQRLHRTEPGIMKTTEVVIHTHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VR24</accession>
    <name>A0A317VR24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Galactose oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_201740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464228.1">
        <property type="nucleotide sequence ID" value="XM_025606102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VR24"/>
    <dbReference type="STRING" id="1450535.A0A317VR24"/>
    <dbReference type="GeneID" id="37108245"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="645"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="700"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="700"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="743"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY76415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="102049" checksum="5BB66CDAAD56C7CC" modified="2018-10-10" version="1">MDVCLLRTHGMRRAVGAPVVSTLLILLLLVVPTFTAVPYAPSQLLYSSNSIGSFAYLLQTTGTSQDASTEFITWNVSGQINTASPSYNILMDPLPFQLDEKSPAFVSVIDQHGVIKMFVGNCQKALDKAGMWQFTPDTNSSTGDGVWEKLTVMESSTGASVDGPNYLSAGFAYAATNTSDSSVYAFGGMCPFSNASETDWIAAANYSQSMIVLEPSGSGRIDSYDASTTGIRAPPIAEAGFTITPLQATYAYSSSGEVRQQQDFLLIGGQTQEAFINMSQLAVFSLPQNSWSFVTVDTASAPYKTELAARGVSTAEPRSGHTAVLSPDGSKVIVYGGWVGNTSVAAQPQLVILELGETYGGSGDWSWSILSTEETEIAGGGGLYGHGATMLPGGVMMVAGGYSIPHSSSLSTSKRSATPSQPNTQVYLYNVTSEKWVSSYQNPDSIVIRQHSSGSGSTAWKTGLGVGVGLGVPVVAGIAILIFFLSRRRQKRRSRDRELRKLALGAERAHFWGRDEPVMASSIRKPAMQEADVNNDYPWTANRGFGRSSIWRDKGDAVAERTGLLGDTLNPTTTGRSGLSARMYRPPTQYSEYRRSDATGDIHPIDEREEDEAKDAGRIVTQETIDTFRESTFLTPLSTTVCGESYTTGSAEPSDYIAGIGFDRDLPSSPDRDGRTSSNLSDSSASAKSMHQSRIINFSYTSSQPSSGRQSPQKIASMSALSREPTRSRANSAALSFEKRYSSDSYSTAQTTLSQRQAEGEHLLREDPESSSPLDLFPKPTTFPKQRASEWIGSNVRRVLSLTRRRPTTDPDPTTAPLASGIDRRSILLAPTPASGYGLPRRSVSASAELFRHKQGARDWGAGNRLSRNIESQVRYSRDDSALHGFLDLGPDSDEDWDVEGAAEGRRVQVTFTVPKEKLRVVNATAGELDNFSEKSVSRSNSDAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRE4</accession>
    <name>A0A317VRE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase</fullName>
            <ecNumber evidence="3">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_549435</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464126.1">
        <property type="nucleotide sequence ID" value="XM_025613447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRE4"/>
    <dbReference type="STRING" id="1450535.A0A317VRE4"/>
    <dbReference type="GeneID" id="37115590"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF313">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016370045" description="Amine oxidase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="5">
        <location>
            <begin position="42"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY76129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="526" mass="58801" checksum="36C3F9B8B2797342" modified="2018-10-10" version="1">MQIPRLAILGALALPSAAHVAHRDEGQCKQTTVAILNRGGGMAGIAAAQTLHNASMDDFMILEYRDTIGGRAWHVPFGQKEDGSPYIIEMGCNWVQGLGVPGGPQNPVWTLAQVYNLSTVYSNYSNVSTYNENGYKDYSYLMDIYDDAYDTAAAQAGMILLDNLQDQTAKTGLALAGWRPKEHDMEAQAVDWWEWDFEDAYTPLESSFVFGIAGNNLTSNGFSDEDNFVIDQRGFSTIIHGMASTFLRPNDTRLSLNTQITNISYSDSGVTVHNSDGSCVRAAYAICTFSLGVLQNDAVTFSPSLPQWKQESIQGFTMATYTKIFLQFNETFWPTDTQYFLYADPYTRGYYPLFQSLSTEGFFPGSNIIFVTVTEQYAWRAERQSDEQTKSEIMAVLRKMFPEKNIPDPIHFLYPRWTTEPWAYGTYSNWPPSTTLEMHENLRANTGRLWFAGEATSPTYFGFLHGAWFEGQAAGREISGILNGTCVGNSTCGRKHYSKLHGTTPLADYSLVDGWNGNSFYDFNTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRZ3</accession>
    <name>A0A317VRZ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-amino-acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_523826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464068.1">
        <property type="nucleotide sequence ID" value="XM_025610231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRZ3"/>
    <dbReference type="STRING" id="1450535.A0A317VRZ3"/>
    <dbReference type="GeneID" id="37112374"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000066">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="36"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY76071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="411" mass="45687" checksum="CC22F1EE59F79996" modified="2018-10-10" version="1">MTSTETPPSFFKATRYIPPDSIFALTAEYNLDPSPEKVNLGQGTYRDKNGQPWVLPSVQKSREILLTQGLNHEYLPILGLQSFRDNATRMALGPDLYERIQSRVSTCQALSGTGSLHTAGLLLRSCRSPLLPKIYIPSPTWSNHHQVFSSLGFVCESFTYYDPVLRSLDIESYYSALRNADPGSVVILHACAHNPTGCDPSKSQWKELGHIIKERGLFPLFDAAYLGFNSGNVDEDAFAIRYFADELGLEVGVCLSFAKNMGLYGERTGCLFLVTRTEETAMNTQSTLEMLQRAEVSNPPAYGAKIAATILSSPELKDLWYKDLETMSGRIRDMRVALYDALIKHGVPGNWDHLIRQSGMFGFLGLESDVVLRLKEDYHIYMAGNSRVSIAGLNEGNVEYVGRSIAECLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSA8</accession>
    <name>A0A317VSA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_196002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464461.1">
        <property type="nucleotide sequence ID" value="XM_025606066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSA8"/>
    <dbReference type="STRING" id="1450535.A0A317VSA8"/>
    <dbReference type="GeneID" id="37108209"/>
    <dbReference type="OrthoDB" id="3556996at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016411088" evidence="1">
        <location>
            <begin position="19"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY77274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="215" mass="23289" checksum="3CFAD0756EB1BB40" modified="2018-10-10" version="1">MLTSTLATLVALTTSTTALLHPRSITPPDGCPLPTWEVTTFHWFNGSKSLDCIHNQADINFKDCLCGDSWCAPDPATCNGSMVNVCWTGMPNYQPWGYGPPETLDIDFADGLTCHDEYIGYRVHDIGNGASNCGYADRGEGRIVSFYGSSDYATSTGHMDYVLGDGHALTCANGSLITYSGSTDFTLTCTHDAYFNATCTAPVFEIPVLSYEWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSE2</accession>
    <name>A0A317VSE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynamin-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Scaffold protein Tuba</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_473036</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464430.1">
        <property type="nucleotide sequence ID" value="XM_025608461.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VSE2"/>
    <dbReference type="GeneID" id="37110604"/>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07589">
        <property type="entry name" value="BAR_DNMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000083">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.900.10:FF:000053">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.395.10:FF:000008">
        <property type="entry name" value="Ulp1 protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051492">
        <property type="entry name" value="Dynamin-Rho_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0965">Cell junction</keyword>
    <keyword evidence="5" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="DH" evidence="12">
        <location>
            <begin position="1191"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="domain" description="BAR" evidence="14">
        <location>
            <begin position="1448"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="13">
        <location>
            <begin position="2017"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="40"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="307"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="407"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="592"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="807"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1030"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1082"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1134"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1268"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1698"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1785"/>
            <end position="1862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="526"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="634"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="897"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1104"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1155"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1270"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1698"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1741"/>
            <end position="1752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1785"/>
            <end position="1800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY77243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2236" mass="247438" checksum="DD89D7BE361158B3" modified="2018-10-10" version="1">MSEGDVEHVSGLYGGSPRQFRRLSSQSTTEFFYDALSNGSRDDPLAALSSPPLPSLSGKTYPSQLGLTSLQPFPAPTSITLEDHRDSYGRSSPDPDDYYRPHLPTVAANDEGDLDSSGRLMVEVNGDAAAEQRPRHFQRVSSVPLHLLESSNAHLGQHRSASDSSYKGVGHESTWGSSSARASTARSGQTSFKDLINKFNNNVDHVLPVPTTSTVRSRVTSRPATPTSPTEGPSHSRALPRLRETHNLPTRQHSYHWHPTSVFDTDSSSDLIPPPLRTTDIDSNPSSNVTSSDAILRRPLLGETLRIDTGPQISGYGTSRRRGSDGIIPSPNPAFLDHLDPSAGVTPLTPTAWYLGRTPFLEAVSSGSNTSIHRRTRSDIAGNWSVEAAYPPPESHMAVPAPLQADSQTCLDNTPQTTKSRIPISSHRLNSPSVSDESPPPSRAGTNSGNRAAVQVHLPPKGASRLPKPSPKSPRDMPRNDQSPGRTASPRAKREMAHGRSRQQLPERNALLEAYIAAPPPKKSPPLRSSRPRQPVSHTQSSRSKVVETVSNFQRQINRDREFRNSRARERRLPELGHVDFATRREKIQQAFNRTVQENERKEEKAAELRRQAKAQEEQGEPAQPPTPEPLQSVEREAEPASHPEDNATVIEEVDAVPDEEPDRVLETTDPRPLPELHVNTDVHTQENAQGISATHMMTMDSPTLGHADIIQRGLGFEPESHPPPASDVTSESNDTHVTAFDTEPQVDLSRQNLHSSHRTLLSQIMHIRESSPSSSSCDEHECSFSETDDRESVPIMLRNAFAFEDHADSSDNPESCDLYMRHGATNGETPNRWSMSSWSSSLRNQHSVDEQCEQSGDEFSQAQQCGEDSEAATQSCSASSSTPSMTGHQLPSSESQKTDETPEIRHAPVSQPNGFAFSSASSLARLGGWDSKRVGQLYLQELANGRGHGLPLPAVRASPEPAHPHFDGKADGAPNSLPDGPVLVSRIGDPPTSERSGHTASLVLRDDWEHASPSIMDWMQIAAAEDGPALQEQNGDARPRHDSALTPRLLTPNPQSSCSEEGDEGLGLAIKVHVPQELESHERYAPPSAHAPEPLGEGAPTDSGVSQQRPQLPSSVNAEQRFSTIISGIFAPLDPVQSTGSSEDSSLRRLEPISSPQTFDSSSTSLVPSTSEQFRLKAQSPSPEQRRLKKRRHVIKELVDTEYTFGRDMKVVDDIYKGTSSSCLDLSADDVKILFANSDQVVQFSMAFQDALKEAAKSVYVMPKSQRWSSKRNARHNTSKTESENSSTAGISDLDKDRMTYIGEAFMAQMGYMEKVYADYLKNHDAANKKLQTLQRNPKVAIWLKECRDWASDLTTAWDLDSLLVKPVQRILKYPLLLAELLDSTPSDHPDHPALVSALEEVTNISVRINEMKKRADLVGQVVGRKRKESDVRTGLSKAFGRRTEKLKQQVGLSDMIEDKVYDTLAQKFGDNFFQLQLVMRDAEMYTREVQTSMDGFSEFVAAIEGFVDVSPSNYAELEGRWRELKVSVGEIMTVALPEHLAVVRKSVIDPMVTLLKLHDGPQRVMKKRDKRLMDYARFRTAKERGDKPDKKTTEQGEQFVALNETLKDELPKLYSLTAKLMEACLKNFVHIQTTWFRQLQNKLGSLFESFPEDIQKIVEDWSCNFNYSEAQVLSLGICNGSLLADTVNLVNFNTPSTGANINSPRRPSTVNSVSTRVGSIMEDSPKVSQDLGNGPHSFHSPSFDSQSQVSHGRHRADSTFSGRAVHETAEIPRSQLLQQITNTSSGSIPASNTNTESFPSLPRLSLDSPFLVDVIGPSNDGTKPEDEPPASPDGRYSGFFSSAMPMSDNPQDNAAARKEPPHDPAVLFLAASIYEFNIDRARREAGYPYLTYVVGEIFDVIAEKGELWLAKNQDDPTHQFHRLAEDRRPTNFAFRPSPPPLPPRLCSSIAGLSIDLSYADLVSSYWPARFLPYVIRPSQPGIASTSRFPLLLGLDTMRDGGLGKLQRRMRRFGDTLNPDDAYLSLTRGDMQSLKNDWLTDNVISFWEEYLEHEFLIQYKSSNIVLLRPSMSFMILQTPNPHSLREALPDFSRTTHVFLPINDCRNVTEAEGGTHWSLLLISIVDGVAFHYDSLPPGNIWEARIVTMKFGALLGRPIRYVHLEDSPVQENGSDCGVFVCLSMRHLLLKRLLTANANEKVSMSLGGRKVDARSGRKEIAKIIEGFRKEGERRRSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTD8</accession>
    <name>A0A317VTD8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_568523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464105.1">
        <property type="nucleotide sequence ID" value="XM_025614684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTD8"/>
    <dbReference type="STRING" id="1450535.A0A317VTD8"/>
    <dbReference type="GeneID" id="37116827"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY76108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45575" checksum="19ADA0B45DE47C8C" modified="2018-10-10" version="1">MSFVDALAEDREMGSISASPLSFERPDYSGLASLPPYWVYKTREVLQCLDDLSTIYQLVREFYDVSQAAAVPAPLILNALEQMYIEDIQHPQITTLSSLVIPNRLEGNAFHELSTGKQLRLDIIGVLCAIAGQACCFALGQDKFRGPTGAARRAEFPKRMMVINDLVTTICRMVTLTNDLTIWTLHESVLISSLVHSYPSSVTWHRLGGLSTSIFEMGLHRDFGNPPIFLRESRHQVHRRSSWNRVRFLMSTFWEEILELSLDYPSSKTADQLRDISRRCQPTWESLPGHLHFSPTCWMQGLPVSVCLMLTLAYLTYLYNEFLMERLLVRHDPHSGNQLLDVSMKILSTVLTVAQHREHTLLLYGFPSASHTRNGKTLPYKGARGALIRDVSVFTSRLETIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVK3</accession>
    <name>A0A317VVK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYB DNA-binding domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_471996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464715.1">
        <property type="nucleotide sequence ID" value="XM_025608411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVK3"/>
    <dbReference type="STRING" id="1450535.A0A317VVK3"/>
    <dbReference type="GeneID" id="37110554"/>
    <dbReference type="OrthoDB" id="2350934at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053095">
        <property type="entry name" value="Actin-binding/GATA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246:SF24">
        <property type="entry name" value="MYB DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246">
        <property type="entry name" value="NEW-GLUE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="90"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY78406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31752" checksum="BF558B744DA343D6" modified="2018-10-10" version="1">MIALQNQAILPPAKVDISLLLKSQDEEEAASVTTAPSFAPSAIPQISVAPAIPVATAASLSSVPSVPPLTSKIPTTVPAKRLQPAHTAESPAKKQSKWSPEEDALIIELRGSGMKWEDISKRLPGRSAISCRLHYQNYLERRSEWDEDKKNKLARLYERFKAEMWSKVAEEMAIPWRAAEAMHWQLGEQEMARRAGVVPFSLSSAAIDPPAPRTRRASTSLSRPRKGSASRPIPPPPQLPSVEELTAGVPAFAPPPPFPGPREAYRLGRPLDLSGGHGGHIGPNLGLPPRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXM0</accession>
    <name>A0A317VXM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_185576</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464593.1">
        <property type="nucleotide sequence ID" value="XM_025606007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXM0"/>
    <dbReference type="STRING" id="1450535.A0A317VXM0"/>
    <dbReference type="GeneID" id="37108150"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="549"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="73"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="800"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="873"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="845"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="957"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1061"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1104"/>
            <end position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY78081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1158" mass="125577" checksum="6962E53E519FB3CE" modified="2018-10-10" version="1">MSVRRDARWHRDSGPEIIAQRCGTPGLGVGQDAPYSRSGQQQARRRWRRKGRPWIGSAGLMFIVLLISWIPPTYAALLNFENCLDAAVIESNPLQLQFVPFDVSVVFDLENSLHPLNISVYGNVSGTANGESYPAPDDPQWSNPNDTVGKIVDVDIANDKRSTLLPFIDVLSFSPYHEASAFCDSVFQGACPLGPVFYVNSSDLSALRAFSLAHDMLSSYRFSTLSSRLVIKSGDKAATELGCISVDITPDLGISLRNTLSYVPLVILLLVGIATVTAAIYSPWGTTDPFHWTSNYGRDEDVLRLVTPGFGDCLQYIQFAVLTGSLTLNYPGFYQPVLSQVAWSVLMFNQSFLDPGREQMPVKDGVYTVNATYGLDRLDRYVGMPAARDIWPGMMVWLLVIVVAITLLIQVAFGLRLLHRTIANNPEEDLRSKNMPFTVGNIIRIVFNYLLLPLVSISFFQLVIAGESPAYSVALAVVVMVILVAFSLWTVRLIATTRPKSYLFDDLSTVLLYGPLYNTFCDDAAAFALVPIFLTFVRGIAIGALQPSGIAQIVLLAICEVVSILTLIAFKPFPSPTSMNLYHACFSIVRFLTILLSVVFVPSLSISQAARGWIGYTILFLHALVMVFGFFLNALQTLIEVIARLAGAGGYDGGVTRGGLVKVFGMRQLSRRVPRQSVATRQSMGSEAAMLAHTDDRLSSQFDGSRPRSLSGSSAMLLNRAGASEGRASAIFDSGSAHGGTHSRANSSGFFTPSTPGGFAAAGYQTPGSNSPKSGPVFPMHPHDPYYRPPRPRKKVVDMGTAGEKGRASRHTQRSASYGETDDDIIEGPSISGRGTPIPAYIPAPKDDLDLDDPRQSRKDYAVREVDFYYRVRGPPLSQSGTRKLKTGPADPTGPVSSATGFFRSLFRGKTKEKGKGFEVVRSSRAPPPGLFPEGEDFHDDPEPYRDELDDQGTAGETHEGSESDAQYHDSDGEGNERPTEAQIVLPKVETGGDIELPSRVGFQHSSQSPSSARQGTGRQGSIGSLAPEEQDLAQKSLSAVTETAIGESAELSHRQEPSVHPSNQLHPSASVTSRLPFSATSSPSRDRNFSIASTSASTTSSRRVNDGSARVERPSSMGYVAQFRTQDNIHEASPDEPSFAGSAAELVDEVHHAGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZ17</accession>
    <name>A0A317VZ17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Allergen Asp f 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_537766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464880.1">
        <property type="nucleotide sequence ID" value="XM_025612347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZ17"/>
    <dbReference type="STRING" id="1450535.A0A317VZ17"/>
    <dbReference type="GeneID" id="37114490"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF2">
        <property type="entry name" value="ALLERGEN ASP F4 (AFU_ORTHOLOGUE AFUA_2G03830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016238802" evidence="1">
        <location>
            <begin position="25"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="34677" checksum="A679AC66D9A3A78F" modified="2018-10-10" version="1">MQLKNSMLLLTALAAGSTVARLHGHERRHHHNDKRAVGDIVVATIDGEKVSWKNEWSGVAATVAVEAEAAVTQIAVDAKPTQVSVTSSVVASVSAVPTAATSSSSSTGATASGSCSSWTQTLSSGDYSRAGFGKSTVSKRTTDAIYYTGNVGSPWGSNIIEVDASNACQYKHVVRIDGSETDDWTVVFWNKIGPTGGLNGWYGHSALTLTIKPGTSRYVAFDDDSQGGWGAAKGDKLPTDQYGGYSCTWGEFDFGNTSNDGWSGWDVSAIQAQNAGQEIQGMKICDHTGSGCSTITNSASSVINAYTAALAAADGIGGSVSAGPVRLQVNIDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W0S7</accession>
    <name>A0A317W0S7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-ubiquinone oxidoreductase 64 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_537535</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465071.1">
        <property type="nucleotide sequence ID" value="XM_025612294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W0S7"/>
    <dbReference type="STRING" id="1450535.A0A317W0S7"/>
    <dbReference type="GeneID" id="37114437"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000002">
        <property type="entry name" value="External alternative NAD(P)H-ubiquinone oxidoreductase B1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="532"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY79499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="685" mass="76644" checksum="1E35AD827F49C15D" modified="2018-10-10" version="1">MSAALLRSRPDPYALTRISLLSRRYQSSRSPASAGFAASRSRLPRRTPTAQCLASRAFFNPRFSVRHNSTAPETNAPPPKSGLRNALFKSFAYCGFFIVMSGAAVVAFFVYDATTYRENSSAEDIPVSELALNPRRGGPKNLPIAEVLIGDNDSEGRLEQKDKPRLVILGTGWGSIALLKHLNPGDYHVTVVSPTNYFLFTPMLPSATVGTLGLRSLVEPVRRIVQRVNGHFLKGEAQDVDFSEKLVEVSQLDANGKEQRFYLPYDKLVVGVGCVTNPHGVKGLENCHFLKTIDDARRIKNQVLDNMELACLPTTSDEERKRLLSFVVCGGGPTGVEFAAELFDLLNEDLLHSFPKILRNEISVHIIQSRTHILNTYDEALSRYAESRFARDHVDVLTNARVAEVRGDRVLFTQEEDGKRILKEIPMGFCLWSTGVARAEICKRISDKLESQNNKHALETDSHLRLIGAPLGDVYAIGDCSTVQNNLAGNIMSFLRTIAWEKGKDPQKLHLTFREWREVATRVKKRFPQASNHLRRLDKLFEQYDKDQSGTLEFGELSELLHQIDTKLTSLPATAQRANQQGEYLGRKLTKIAAALPGMQANQIDYGDLDEAVYKAFKYRHLGSLAYISNAAIFDFGGLSFSGGVLAMYLWRSVYFAESVSFRTRCMLAMDWAKRALFGRDLMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W288</accession>
    <name>A0A317W288_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_496218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465348.1">
        <property type="nucleotide sequence ID" value="XM_025609283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W288"/>
    <dbReference type="STRING" id="1450535.A0A317W288"/>
    <dbReference type="GeneID" id="37111426"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="554"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY80746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="794" mass="86439" checksum="9371228EF3DCC50E" modified="2018-10-10" version="1">MSTKAGRFAAKALGIDLTSNPPLDARDAPVLPEQTGSYVEVEPTAGEWLRGLVPSGQQVYHYFYSMFPFLHWIMSYNLQWFIGDLIAGVTVGAVVIPQGMAYAILAKLPAEYGLYSSFMGVLIYWFFATSKDITIGPVAVMSTLVGTIIIDVQAKYPGVEATTIAQALAIICGAITTFIGLFRLGFIVDFIPLPAITAFMTGSAINVCAGQVKTMLGETASFSTRGATYEVIINTLKYLPTTQMDAAMGLTALAMLYAIRSACNYGTRKMPQKAKLFFFISTLRTVFVILFYTMISAAVNVHRRHNPAFKMLGKVPYGFQHAGVPKINVDIIKTFAPELPAAVIVLVIEHIAISKSFGRVNNYTINPSQEFIAIGIANLLGPFLGGYPATGSFSRTAIKAKSGVRTPLAGVITAIIVLLAIYALPALFFFIPSSSLSAVIIHAVGDLIAPPRVLYQFWRVSPLDAVIAFIGIIIIIFSTIEIGIYCTICMSLAVLLFRLAKARGQFLGHVQIHSVVGDHLEETGSSKEFNPASQLASSRTAFLPLAHTDGSNPAVPVLQPAPGIFIYRVSEGFNYPNANHYTDYLVQHIFETTRRTNPSLYARPGDRPWNDPVPRKSESEDLSQKPVLRAVILDFSAVNNVDVTSVQNLIDVRNQLDRYAAPDRVQWHFAHINSRWTKRALAAAGFGRPSEETPMKAIFSVADVSEYAEVPKRVSDIESQDGTVVGGEEISKQTAGGDDKTSGMLRIRERRGEYKRAVAVVTGVNLPFFHLDLTSALECAVASMSEHPSKAPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W533</accession>
    <name>A0A317W533_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_521352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465256.1">
        <property type="nucleotide sequence ID" value="XM_025610146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W533"/>
    <dbReference type="STRING" id="1450535.A0A317W533"/>
    <dbReference type="GeneID" id="37112289"/>
    <dbReference type="OrthoDB" id="5579281at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902657">
        <property type="term" value="P:protein localization to prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040345">
        <property type="entry name" value="Mug56/Spo71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039486">
        <property type="entry name" value="Mug56/Spo71_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057379">
        <property type="entry name" value="PH_SPO71"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029217">
        <property type="entry name" value="Spo7_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076:SF1">
        <property type="entry name" value="PROSPORE MEMBRANE ADAPTER PROTEIN SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28076">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15404">
        <property type="entry name" value="PH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23207">
        <property type="entry name" value="PH_SPO71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15407">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01316">
        <property type="entry name" value="Spo7_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="574"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="844"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1029" mass="118060" checksum="09CD99CE82314AF6" modified="2018-10-10" version="1">MHMTSRRFFIGPIPQGWLQNHRKSWWRTRIKFGKYSSKTVTFSADPIVAHYSEVSDTDQDDSTPEQSPAALTDTTEDEGTEREQEDEISDQEEHPKTSLRTVPYTLAEDHDISRITTTASDTAMSNSGDNEHDWHSSMGRRDGSSAYYTAREQGPGDADRVSLRPSTVSPEQHGQGSSKQTLSTPSQNGASQSSPMAPASDYGSTTALLRPDSRSKGKGRVPTTSSMNLEQQEPQVETAEEEPLRNGQRARIDPLNPFSRKAAKHNLDDNLLDKQQRVLARISRTQAKLSRNLPHRRKMKEGEVIKAEKMLVRIEETVQEKLPDDYSENDSYKMETRVVDHWREYLVACRLASDEDAPFSLQMYKTRVIPEVQKVGTRVAPYYEVPLGRKKMKVNLYSHLDKAIVLWGPCKHGTKIYIIRPRSSAHAVEWFTFLSQIMGKRRPSSLPIHVPDLGVSLVFNNPFDQLEAVLQKRNTGILSGTIAQEESAATAIIRGCLKMLENRAEWAEVLQRWSKTEIMGLAWKRYDRLEWILGDNEEKMYGSLAMHTTHELELRPRQHYKTYTKHDGEKADEPQPVEGFLVRLTSQRGVHQRMNKMFFKRLYFFTQDHYLFFCRPAKSLPPAPPRLCRNGSDMPSTQQILDASPLSYEVDPYPLQEGGISWLSSGNKEHIRKHDEEAYVQRQRDIHNLEHADGFIDLSKVQEVRHVRRDSCPADPNIEAGPDVEFHPEARDTHRDDGATRQFNDDKTFEMVLENKLVVRFQAYNETTKTEWMKRLEALVKYWKNRIATDAAEIKVLRQRNLELLGIDEELESIMGQFAKKWEVKKAEASPLLHNICLLSGCRTIKISGQLYRKPRRHSTFKKSHVVLTAGKLLVFRSSLRKRNGVEVPHIHQSLETSIDLNDCYIYSGLLTDSDLLYANQTFDSNHPGHHSLPRVYLSSDVYTSSDEDTAITFVIWQPLKKNLFRAREHGLKGQTKQRLKQVSTLGVHGRTIVFKARSRVEKDRWVLSIASEINRLQEDQPEDVRIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5K2</accession>
    <name>A0A317W5K2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_603097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465002.1">
        <property type="nucleotide sequence ID" value="XM_025616435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5K2"/>
    <dbReference type="GeneID" id="37118578"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="57"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY79430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="424" mass="49228" checksum="617D5B49EAA41D24" modified="2018-10-10" version="1">MSSRRHRLLPEPFYRIVDDLDEIDLRSLRLISREANRRGRRRPFKPHRRLRVQYGPSSGFNKLPVELLYMVVNLLEDRDMISLQRVSKRMTSVTYERSCLIFDRCLRTIRTDLSSSSIAQIQYLASHPVFHHIPQALQIVPPFGPLPNIERSSSFNEIESPASIPTLKILKQLLQYSLPNCKSFELCLDSNENDHLSTDDVVQILFHLFAETERSPEQLTLYSQSSPSPETSPQDLRSLYRITAHPDISRAWTNLHTLTISEPYFQHLCWSLEFIFPLILEHAPRLERLIIIGSNTKDYNSVNALTAINKAIPMCGLKHIEIRNWEFRDHGFHDWLSANGHQLTSLTFSECATEPYQGWHDMLGDVQSYCTALESITLDNIKDSTRESRYYRTYKGTGMMAKLEELKIELRAWDPEPLAPLILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5M9</accession>
    <name>A0A317W5M9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_169985</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465032.1">
        <property type="nucleotide sequence ID" value="XM_025605918.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W5M9"/>
    <dbReference type="GeneID" id="37108061"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF48">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SDGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="4"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="937"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2371"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="937"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1082"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="969"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY79460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2463" mass="268824" checksum="E9BB22923D80C096" modified="2018-10-10" version="1">MSFPEPIAIIGTGCRFPGSASSPTRLWDLLHHPRDVASKTPSDRFRHDTFYHPDGHHGRTKAPESYFLTEDIRAFDAPFFNVSRAEAESMDPQQRLLLEVVYESLETAGLQMEGLRGSDTAVFCGLMNTDYGNLASCDWDEIPTYTPSGTASSMLANRVSFFFDWHGPSMTIDTACSSSLVALHQGVGALRNGDCHLAVIAASNLILSPREYIAASKMHLLSPTGRCRMWDENADGFARGEGIASVVLKRLGEAIADGDPIESIIRATGVNADGRSMGITMPSSMAQSQLIRSTYAIIGLSPTARPEDRCQFFEAHGTGTQAGDPQEATAIYKALFGIPVPPDKSSEDWLYVGSIKTVIGHTEGVAGLAGVIKASLSVQKGIIPPNMFLDRINPVIEPLTSRLRVPTEPMPWPSLAPGVPRRVSVNSFGFGGSNAHAIIENYTPGTNLVLGHTLSPQILPFTFSASTEQALTGVLEHYGAFLQNNFDVDLVSLAESLLKRRSALSHRIALTAASIEDLQSMVQIEIEKRRSATASPAIVSRSSDTPRRVLGIFTGQGAQYPQMFWDQISASPQALAWMAELQASLDSLPSQYRPNFSMIQELSAPESSSRLHEAVISQPLRTAIQIIQVNFLRALNVSFSAVVGHSSGEIAAAYAAGAITASDAIRLAYLRGLMTKHAGANGQPGAMLASGIPWEEAHALCDEGFSGKVRVAASNSPVSVTFSGDVDAVQELEWMLKSLDLSVHRLRVDVAYHSHHVVPCAAPYRHALEVCGIRVHPVMTKWFSSVYKDKELHEEDLSPQYWGQNMLRPVLFSQAVAAAFTDEPEIGLVVEVGAHPTLKGPILQTLSVIKDAKSEVAYLGLGERGSNNLEVFSRAIGFFWAYLGPNIDIHGYLSLFDRSYGSRFLKNLPTYPFDHSRSYWKLSRLTNARLHCIDPPHPLLGTPSPETGGNEWRWRNHLSRAELKWLNDHQIQSQVVFPATGYIVMALEAAAIMARGLSLRLVELDDVLINRAILIPDDPCGVETIFKVELIERKGDIVFAAFQCYASLAGSLKACASGKLTVLFGEQDPLLLPPKSSLVTTSRPVNVDAFYACLGRLGLGYSGPFRGLKALTRRVEGSMGIVSGTDPTSSLLLHPATMDSSLQALLAARSFEELRALQVPVSIDHVAINTLLCKHDSRGTKNELDIETFLYDVNPDGMTGDINAFNLDGLGIYQIEGLHVAPITSAEDRAIFSKIIWGPLLPQVNPNNIYQDSRIQEELHLAERCALLYMRDAQQHLVSEECEHLDWHRSRIIAWMDHVLSTTREGTHPVCRPEWLVGTVADVMDMAPAASNAWSSLRLAGENLPSFIKGMSVSDQESNRDGGLNDPFDVNFSNSQLAVFIGQIAFRFPQMKILQINAGSGSATKPIMNEIKRSYHSYIFTDVSPASFAAAQEAFSGHKDQFSCQVLDIRSDPCHQGFKEHSYDLVVAAGIMCNHRELVQALTNIRRLLKPGGYLVVHAATNTNINRLALIASFEKWWYDEEGHPQSPAISLQKWETLLETTGFGGFEAVSPAGQLESGSTFVTQAIDSRIQLFRDPCKFLGVLPANLLLIGGTTEATADLVQSLKALLAPRFRRLVVATALDALNVEDLFGWCALNLADLDSPCYEDITDKCLSGLKMLMNSASRLLWVTAGSESRQPYWGMSKAMIHCVAYENPQSIFQYLNVPDHEEITAPTLATIFMRLAHTLMDNDHDLDTCVDSTEFELQLVNGTLNIPRVHFDDIKNQRYSASYHVVKGLVVLQHSTVQVIAPSGKRCEFILGERQKYEQDAKEPQVTYRPLTSRFSTTTAFKIDGAGFLHLIVGRDEKDKTRWLALSDQHASAITAPPEWCWQVSDRVGEDLEPILLMRTAAALLAIQIVDKVRSNTSVLVYGADTLCKAVCDALSAFALARNIRVCFSTSAQSTPPKKDMLFIHERSSSRTLSRLLPDNLSAITGSRATCGVYNRIKTLMSEDVVQIDIASIGRVSSNLLASPDSTTAGQTFLAACGFALQTFTSQEEVSLIPVQRLQGTFPGANQLEIVDWTQSGQVPVRIQTASSMITFSAHKTYLLAGMTGDLGRSICQWMVSRGARSVVLGSRSPHVDVQWIEEMARLGARVVPMAMDVTNRGSICRAYAAICSELPSVGGVVNGAMVLKDCLFAQMTLEDMQSVVAPKVQGSIILNEVFGNLDLEFFILLGSAAGPLGNVGQTAYSAATEFMSALIQQRREQGLVGSIIHPGLIKGVGYFERADSARQGAIERNTVTPHLTEQDLYELFAEGILAGHPDSGRDPEVIAGYTLIDTAENPNALWLRNPKAWNLIKHTAHPATPASSSNDSVPIMIQLESAESMAGVVEVIVNGFIKEVRSKLQLSTEESLTGATVLTDMGVDSLVAIELRHWFVKELSVDLPVLQIIGGVSIQELSSCAASKLSADHIPSIIIQQTAPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5P9</accession>
    <name>A0A317W5P9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division cycle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_558341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465553.1">
        <property type="nucleotide sequence ID" value="XM_025614003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5P9"/>
    <dbReference type="STRING" id="1450535.A0A317W5P9"/>
    <dbReference type="GeneID" id="37116146"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="413" mass="47181" checksum="F725AFE0AC359961" modified="2018-10-10" version="1">MPLIEPEAPAPAADTPIEELTRLPFPPVTYSHILNCSYHQWQPRYRTLVPKSRAIRLSAPFVSYLRADGIVLPPEAAPPTDDDDNDDTFSDDGADEEPDPSLEWPEIHAQIKSTITEYGGKVTPKLNWSAPKDATWMSATNDTQCRTANDIYLLLKSSDFIIHDLEHPFDDCVPDTTESSSSAPPEIPYYLVLRKYVNFNPSLEFRCFVRNKVLLCICQRDQNHFDFLFPMRDSLRSRIQSFFDDKLRDTFPDPNFVFDVYIPPPHERVWLIDINPWAERTDSLLFSWLEILRMKDPVGIQEEEVQFVRLSLNGHDGETADAELDEESETESESESEPTNENDAPLFPEFRLIKRDDPEAYAFTTPQYSAHKLPKEVVEASMTGPGGMSEFLGQWQDILAKQAQESDSETEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WAE0</accession>
    <name>A0A317WAE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_587076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465964.1">
        <property type="nucleotide sequence ID" value="XM_025615799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WAE0"/>
    <dbReference type="GeneID" id="37117942"/>
    <dbReference type="OrthoDB" id="4156714at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="228" mass="25870" checksum="DA06106613519696" modified="2018-10-10" version="1">MDKNPTGDASPTKSPIKSTHGSTDPPPSDKETLPHTQDVEALMAEIDHLKWKVAILKGEAGEKSSLCNEQSLILFSGGEGWLPVYNRELEAEVKSVLQDVGNWCRQYALGGPTEVAHLSPCEKQSIIRSLEGYWVQDLDWDTLMRSFPFPISQNVLQLVAQTMLTKDIIEKVFENPFWYLEASDQQEKSQRSDCFAWHLQRLYLPFVESKPVTLHTDAPPRFFLLHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WAM9</accession>
    <name>A0A317WAM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_123275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466044.1">
        <property type="nucleotide sequence ID" value="XM_025605588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WAM9"/>
    <dbReference type="GeneID" id="37107731"/>
    <dbReference type="OrthoDB" id="4366200at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="124"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="323"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="574" mass="63581" checksum="A5C1E581E6011974" modified="2018-10-10" version="1">MKLHHPAHTIQHKERLLSVRGVHTTPTLHNDAPNCTDRLENFVKSHTGDEPHTKVGCTTEEQHSVCSQRDESAGTSTGATPRSPSFDINPSGYDESNSNTEDLYDPLFDDDFDLQGFDAVLPSRKRDGDEAFPDECASWDQPSKRQVTEPKQDLTTVSPDNTPSLSSLDSVQPDQGGTGPHTPSDIEKQQSLATLFDPIDLLLEDPTCDIALNIPDGEIPFSFDFQGACNGQELKEDIRTIYDIPDQALELPSISEITKERFSLNDSNIIDNTHREVLQQVYVEPEYASPYPAHGGPLGYLPSAPGLHVRCMEVSEDRINYRLSNLRTKVHQLTLERNKYKQELARVSDLTAVDPETGKTKRQLLLEQNAMLRRVCSRHRQRVEEYKQEAADWKNKLHHLSVTHNCLLYEIQTQNQVPKVNPMPPGYKPPRVRHVNPDAQAVDSSAPPSASAGGPSVPGARAEPLMIDLTDEPGDDVPAETPEEFRRRTEMFQSLRAKKYPWLADGEAEVGNPALRMTSGSPAQGSPSSAGGPQDSGRSRDHRPANPPRDIASADPAHHDADLAQNMEPELGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WAZ2</accession>
    <name>A0A317WAZ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_536358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466132.1">
        <property type="nucleotide sequence ID" value="XM_025612001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WAZ2"/>
    <dbReference type="STRING" id="1450535.A0A317WAZ2"/>
    <dbReference type="GeneID" id="37114144"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="54"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY83664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="551" mass="60941" checksum="8BD3339F6A5A231F" modified="2018-10-10" version="1">MDKKSTQPAKDLAPDGRSSIHGFTHHAEDILPDREPYGPPGIRGLIANPFVLMCAACSTLGGLTFGYDQGVVSVILVMDQFLERFPEVNSGFWKGLMTAMIELGALIGAFNQGWIADKISRRYSIIVAVCIFTIGSVLQTASVDYAMLTVARLIGGVGIGMLSMVAPLYISEISPPECRGTLLVMEELFIVLGIVIAYWITYGTRYMAGEWAWRLPFLLQLIPGFILVAGVIILPFSPRWLVAKGREEEALHSLSRLRQLPTNDKRVRQELLDIKAEVRFHQQLNAEKHPNLQGSGFKNAVLLDLACWADCFKKGCWRRTHIGIMMMFFQQFVGINALIYYAPTLFETMGLDYSMQLLMAGIVNVGQLVGVTTSISTMDKFGRRALLLWGVAIMATCHIIIAVLVGLYSDNWPAHRGPGWASVALLLVYMISFGGSWGPVGWALPAEVFPSSLRAKGVALSTCSNWLNNFIIGLITPPLIEDTGYGAYVFFAVFCVLAFVWTFVFVPETKGKSLEQMDEVFKDNSSEAEKARRRAIEADLLREEEQTVLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD97</accession>
    <name>A0A317WD97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_599438</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466373.1">
        <property type="nucleotide sequence ID" value="XM_025616323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD97"/>
    <dbReference type="STRING" id="1450535.A0A317WD97"/>
    <dbReference type="GeneID" id="37118466"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF6">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE APDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="15"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY83905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="351" mass="37794" checksum="EEE355BECAEC7953" modified="2018-10-10" version="1">MDNKKQEALVASGMGRYLLSQDVPVPTVKPDTILCRVVAVALNPADWKMVDFSATPGAVGGNDFAGEVIEVGEEVTRFHKGDRVFAMTFGLNPNGKHTGAFGRYALATADLACKVPMGISWEEAASLGLAIGTAGTALYHALRLPMPDSPAKQPHYVLISGGATATGTVAIQLLKASGLTPIVTCSPNHRELVLSLGAEEAFDYQSATCATEIRNYTNNTLEHVLDCVTEAASMTLCYEAIGSAGGHYIALDPFPTHIQYTRRDIKAEWLMIYSLFGEPVKLDGVYGRPARPQDRDFAAKLFPLVEGLLHEGRLQPHPIEIRHGGLGAIERGIEELRKGQVRGKKLAYPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE34</accession>
    <name>A0A317WE34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="11">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_587160</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Probably involved in the regulatory network controlling carbon source utilization.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with creD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466053.1">
        <property type="nucleotide sequence ID" value="XM_025615804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE34"/>
    <dbReference type="STRING" id="1450535.A0A317WE34"/>
    <dbReference type="GeneID" id="37117947"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000053">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0436">Ligase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11 13" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="15">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="16">
        <location>
            <begin position="395"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="17">
        <location>
            <begin position="484"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="140"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="254"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12 13">
        <location>
            <position position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00056180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY83268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="817" mass="92551" checksum="078E05B2EA7710AD" modified="2018-10-10" version="1">MGSNLPPQPNLRVTIIAADGLYKRDVFRFPDPFAVATVGGEQTHTTSVIKKTLNPYWNEMFDLRVNEDSILAIQIFDQKKFKKKDQGFLGVINVRIGDVIDLQMGGDEMLTRDLKKSNDNLVVHGKLIINLSTNLSAPIPNQANGLHRSHAQSSTSSGLVPQVSSASHPSATPSQAEPSATALNASLHPQRVPSTTRPTSTVGPVNGAPPPANAPHGSRTNLSSFEDSQGRLPAGWERREDNLGRTYYVDHNTRTTTWTRPSSNYNEQTQRTQREANMQLERRAHQSRMLPEDRTGANSPNLPESQQQQAHTPPAGGSASAVSMMATGATTAGTGELPPGWEQRTTPEGRPYFVDHNTRTTTWVDPRRQQYIRMYGHNANGGNTTIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQGVPQYKRDFRRKLIYFRSQPALRIMSGQCHVKVRRNNIFEDSYAEIMRQSASDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGVNPEHLNYFKFIGRVVGLAIFHRRFLDSFFIGAFYKMMLRKKVSLQDMEGVDEDLHRNLTWTLENDIEGIIELTFSVDDEKFGERTTVDLKPGGRDIPVTNENKGEYVELVTEWKIVKRVEEQFNAFMSGFNELIPADLVNVFDERELELLIGGIADIDVDDWKKHTDYRGYQEQDEVIQNFWKIVRTWDAEQKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKSGDPIALPKSHTCFNRLDLPPYKTHDVLEHKLSIAVEETLGFGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEY1</accession>
    <name>A0A317WEY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_536463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466250.1">
        <property type="nucleotide sequence ID" value="XM_025612023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEY1"/>
    <dbReference type="STRING" id="1450535.A0A317WEY1"/>
    <dbReference type="GeneID" id="37114166"/>
    <dbReference type="OrthoDB" id="201656at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="18"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="338" mass="36465" checksum="F2E15D16BCFA8A5F" modified="2018-10-10" version="1">MSHPTTMKAWLYSHTTPTLEQNLTLTPTATPPPPPKPTQLLIRVLTCALNPADYKVPSMPIISRLLIRKPASPCLDFAGEIITPGSSVTEFTAGQIVYGTLPLPTQFGPFGEYILAETEHVQLVPEGVGIDHAATVGVAGQTAWQAISPYVTPDKGDKVLIVGASGGCGIYAVQIAKALGCEVTAVCSTKKVEFVKGLGADEVIDYAKEDVVEVLKGKGKVFKLVVDHVGEPTGLYAESEGFLVPGGVFTQVGAHWMPTFMVRMLRPRFLGGGKAKYVPIFWKSNRRDLTKVGELIAEGKVKVVLDSVFEFEEAPKAFEKLREGRARGKIVVHVGERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHB1</accession>
    <name>A0A317WHB1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_566396</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466666.1">
        <property type="nucleotide sequence ID" value="XM_025614550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHB1"/>
    <dbReference type="STRING" id="1450535.A0A317WHB1"/>
    <dbReference type="GeneID" id="37116693"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="44"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY85649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="247" mass="27472" checksum="3151B1E9661202E0" modified="2018-10-10" version="1">MANYVSEPIPSPAQGVGPLYRPDGEKPTATVSKDISYENVHILPQSPQLIALLTMIRDKRTSRADFIFYSNRIIRLLVEEGLNHLPVVEQSVTTPVGRVYLGVKFEGKICGVSIMRAGEAMEQGLRDCCRSVRIGKILIQRDEETCKPKLFYEKLPADIANRWVLLLDPMFATGGSATLAVEVLKAKGVPEDRILFLNLIASPSGVADFAERFPRLRVVTAFIDQGLDDKKYIIPGLGDFGDRYYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ32</accession>
    <name>A0A317WJ32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_585922</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466920.1">
        <property type="nucleotide sequence ID" value="XM_025615724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ32"/>
    <dbReference type="STRING" id="1450535.A0A317WJ32"/>
    <dbReference type="GeneID" id="37117867"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY86329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="206" mass="22861" checksum="7A4ECB2E3C2D1BE8" modified="2018-10-10" version="1">MILDFPNTPYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTVKLQIWDTAGQERFRTITSSYYRGAHGICVVYDVTDMDSFNNVKQWLQEIDRYATEGVNKLLVGNKSDMEDKKVVEYTVAKEFADSLGIPFLETSAKNASNVEQAFLTMARQIKERMGTATVNNKPTVQVGQGQGVQSGSAGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ90</accession>
    <name>A0A317WJ90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_467003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467115.1">
        <property type="nucleotide sequence ID" value="XM_025608190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ90"/>
    <dbReference type="STRING" id="1450535.A0A317WJ90"/>
    <dbReference type="GeneID" id="37110333"/>
    <dbReference type="OrthoDB" id="5359231at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY86524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="662" mass="75305" checksum="4B4A80976C1D7BC2" modified="2018-10-10" version="1">MVVAAMAKNLDCIPYDVFYQVASTLDCQDLVHLSRVNRTLNHLIQNESIARKAIQNDLLHTKEGQQASQAKTGYRNALGRLFDIKESFATAQPYSASILAYGSSFLYSDGCLCYIYNEEIRLLDVHGASQVEQVLNIQNVLSRAIPDCNPQEDTIQICPMHYSDGILAFTVELVDRPDAWLLVMDMRRKVEHKKSGRLRLLTQLRHTRRLFVRHNGSYLYYGTHTAMGDRGFPQWAINCVDLKKGQPTIDKPVVLENFAGSEVGQTVCFEIHQDHLYAVSTLVDFEAEEVDWTSYYVWLCLSPQANDKKRYIMPNRTWRRQHREGPINDTWSDLTLRHDEATKRLMILECRREWRDGGSENARTYYMQPLPSPAEVAQQKQQGSGAAPNITPVALPDEPLTRTLDSTNKPNYEPPRKRLRRHFHQEYAQGVEPTQRRDYILAKTKFRSYNLSASTFVDLVNDPSPERPGSFISHDRLRVRVVSRKRKCPIDEAGDEGEPGLLFRPELSNADGQPIEHSEERYASRGVSLWPPDDAPRELTQLLCPSKRCGPVQAAADERSLVYSVDQEGLEGTGNQAIVLINFDPSLRLPGLQRMDLTRGGAVATDECKAAVGMERPSIGDIGRERFGVHTSVGSRRTNQPMPSVREERAMYLSIRRGYWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJK2</accession>
    <name>A0A317WJK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_586213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJK2"/>
    <dbReference type="OrthoDB" id="4510178at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="323" mass="34240" checksum="B30A7F65698C4F42" modified="2018-10-10" version="1">MHLSRLATALREKPLGAGWRIAMSPRAGMNPLQTTEVTKRVVAGRLEGASGWGTGAEPGSLLLLFTNTTRQFADIHGGGSVTAVPRVSSSLPLLLPGLPFHAATEGRGQLAAQVPGAPRLRVSVGAGVQGRAGVRAGKGDLPVGWVKLNHERRRGRKRAGVGPGDAEGGGRGAIPAWEGEGSTLGRRGCEGGAREAVPGREGGTSAGRAGRRTASSRSSTATAPLRTRRHTRRPNIYIHTSHVSHRHVGAHTLTRTDIYNPTPPDTPTHPHTDVHSPSRQTHRRLYDDAGTSTHPWDDRESDDIDLGCTSGRLPKPHVARRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WK10</accession>
    <name>A0A317WK10_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="7" type="ORF">BO94DRAFT_468323</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WK10"/>
    <dbReference type="STRING" id="1450535.A0A317WK10"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="257"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY84540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="474" mass="54335" checksum="E40F0DA71FC063C7" modified="2018-10-10" version="1">MAANVPPSAETLLSGAAAHPPKTAEEIANQYDLLPKLIPYLDRHLVFPLLEFSSGSQDDDKEMIRAKYELLKHTNMTDYVANLWKEINDSDTIPDEFVKKREEVLAKLEHYQEQSAKITELLQDESVVGNLRSDKVANLKFLEEEHGVSVDMVNSLFDYGRFQYSCGSYGNAAELLYQFRVLSTDNDKVASATWGKLASEILTTSWEGAMEEVQKVKDSIETRLFNNPLGQLQNRSWLIHWSLFPFFNYDPARDVLTDLFFSPAYINTIQTSCPWILRYLAAAVITNRNRSHKNSNAYQKQLKDLIRVVRQEGYEYNDPITDFVKALYVEFDFEEAQKKLGEAEDVLRSDFFLVSAADAFVEAARHLISESYCKIHQRIDIKDLSTRLGLNQDEGEKWIVNLIRDTRVDAKIDYKEGTVIMNHPPQSVYQQVIEKTKGAFFRTQVLRFVSRQTKSTALSTCTNVIPIVLPLRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL22</accession>
    <name>A0A317WL22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_624890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466774.1">
        <property type="nucleotide sequence ID" value="XM_025617248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL22"/>
    <dbReference type="STRING" id="1450535.A0A317WL22"/>
    <dbReference type="GeneID" id="37119391"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY85757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="136" mass="15999" checksum="BE6B4ACBD9C13CC5" modified="2018-10-10" version="1">MSTILRTLRNLKRIGFKEYGHQMQYIGDTKAGTLIGVDRYGNKFFENVEEELPLRTRWVDYKDHEYDPSHIEPGWHAWISYMVDAPPTADKLMQTGIRRWELPEHRPNLTQSRAAFKTYSTTRPKYSAWTPVAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL92</accession>
    <name>A0A317WL92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_596518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467462.1">
        <property type="nucleotide sequence ID" value="XM_025616258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL92"/>
    <dbReference type="STRING" id="1450535.A0A317WL92"/>
    <dbReference type="GeneID" id="37118401"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="252" mass="28581" checksum="05641FDC6929A20C" modified="2018-10-10" version="1" fragment="single">VISCHGYYPPGVSKVIGRGGWCYIGLIDDSTVLKYPKIPGEGDNIKVEAQILNILGYHPRIIKSHGLTDHGLVLQYALKGNLDEYITHNPDVSVEQRPHWCKQTAEAVSYIHEKNVMHCDMGPRNLLLDDDLDILLADFQGVLKSADGRILLDGLSWEYPKYYCPRAHCDYIDVKTDVFALGFVIYSIIMGHEVFPELNSWEHDEEIEARFANGQFPTDRHPCFEITEKCWKQLYESAGDVVADLSQIQLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMS4</accession>
    <name>A0A317WMS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxin 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_492270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467239.1">
        <property type="nucleotide sequence ID" value="XM_025609176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMS4"/>
    <dbReference type="STRING" id="1450535.A0A317WMS4"/>
    <dbReference type="GeneID" id="37111319"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="440" mass="48817" checksum="827973D6E86AE1A3" modified="2018-10-10" version="1">MADDGSYLSASQSQLLSSSTSPLSPSKLCSKTYKKASNLFLTRRLQETLSALEPAITVARRPDEQFTNGDDSVAPVAAAQPTWRIKVWNLYITLLSAIIELGPEEGKKLFGQKEWKAISTTVREGEIWETIVQTGYRGLEGSVDAEVVYNLATLLLKHSPSQKLSQQRLETYLSSYGQPNLDITEHLRNGSSTPRQTNGGTDTPKDLVARVRIIELFTLHVLPANEEWEYAQEFINLSEVLDEERKDVFLQTLEGLKEEKQQGELRAAALQREKDAELERQAREAERRRTEEAEAAERSQKGHGRSGSEVDYGIEKTYPNGSIKGKGKNAEKQPSSKPGTSAGRTAFSPPGSKNIKKADKPESRAKQSRALVNAVRNILQYIRKSIAGNPLSFARTLLFMLGIIAALSRQDVRERVRRIAGSGWQKVKGTVGMGVKVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN95</accession>
    <name>A0A317WN95_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory factor Sgt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_585398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467712.1">
        <property type="nucleotide sequence ID" value="XM_025615691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN95"/>
    <dbReference type="STRING" id="1450535.A0A317WN95"/>
    <dbReference type="GeneID" id="37117834"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="605" mass="68529" checksum="1DA9AA1490401419" modified="2018-10-10" version="1">MVPMSEEDLEWFKSTFRPIPKPELPDDSVDYSLYYIPTSPAPAIVDEVAETRARLVEVQRTSAELVKDLLKDHIWQRESFRLEITKDDGVTSLHGRTNFGDSIEDEWVIVYLLRELTKKHNNVWAKAVDGDGQFLLVEAAATLPAWLEPEVADNRVWINQGQLVIIKPKADKKDRVTEKISLSDAKKIISEEPERLMRSTIIQEEAFYRLRNYPNQINENLHSALVIIPRKVAFLLHQKPAYISAAVEAFYLRDPIALRPLRTKDSNSFIFKPEDFVTASVRFTRVGYAQLKSQDFPVPKSWNDNLPSTDNQKVYDRAEIGMKLACGFEMLLTDPQNQDKAAVREMNLILEDLDTGDEQLPTDKEMETWDRREDDEKWLDISFEDLDRELKGKGKGKDGEPLAEGTFGDANAQENLQRIVAQFEKFLNDDSAGFEGAEFIDDYDSDTDDEEEMSSDGEDKDASFDEEEFSRMMKEMMGMPSKAGLQGSSRPSASRSRVEELDSESEDDTEQIKELSKQMEAELRGTGVLDLNRKAKALGDKQALADGKSGEGEDGDMPELEEEDIDINFAKNLLESLQGQAGTAGPAGNMLSMMNLAMPKDDRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNH0</accession>
    <name>A0A317WNH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_534914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467696.1">
        <property type="nucleotide sequence ID" value="XM_025611653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNH0"/>
    <dbReference type="GeneID" id="37113796"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="62" mass="7032" checksum="07D5C02A5BC2F667" modified="2018-10-10" version="1">MMQKINSNQQQTHNNSIHSHLTKPTKITPYSSTILPHQQPQTLKLSPQLYRSPRSGDTHIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNK1</accession>
    <name>A0A317WNK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_535968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466847.1">
        <property type="nucleotide sequence ID" value="XM_025611908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNK1"/>
    <dbReference type="STRING" id="1450535.A0A317WNK1"/>
    <dbReference type="GeneID" id="37114051"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001115">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="46"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="238"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY85830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="361" mass="37958" checksum="373D165A4150A1D4" modified="2018-10-10" version="1">MSAAVENTADNVASVPATTSPEATNGTAPAPAQSTDAAAASADEGRRLYIGNLAYATTEGELKEFFKNYTIESVSIPVNPRTNRPVGYAFVDLATANEATAAIEELSGKEILQRKVSVQLARKPEPAEAKAEGAASGGEGASGNEGRKRAGGRGRGRGRGRARGGRLPRAGRSQAPAPNGQDTTEPATIPDEAAPLAEVTDQNETVASGEAGKQAGKPRAPRPQKQRGPPEDGIPSKTKVMVANLPYDLTEDKLKEIFADYQPVSAKIALRPIPRFMIKKLQARNERRKGRGFGFVTLGSEELQDKAVQEMNGKEIEGREIAVKVAIDSPGKEDDAVAPAEKTEEEVTEAPAQENAAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WP77</accession>
    <name>A0A317WP77_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_545992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467588.1">
        <property type="nucleotide sequence ID" value="XM_025613274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WP77"/>
    <dbReference type="STRING" id="1450535.A0A317WP77"/>
    <dbReference type="GeneID" id="37115417"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41401" checksum="056D0ACFC3383C30" modified="2018-10-10" version="1">MGNCISLRRRRSPPEAKKPRKTHAPLERLPPTVFYRIARYLDQADYNSLYCCSEEMAGLAKPCICASLPAGLQIGQNSSENEIMHMLATNPETNHLPMSLHVILPYIGDKDARNVSEGGLSYDPEALHSTPEMGTVRRDLNNLVNCKDLHFTLARADQSTGLKSNNKVLYIEDALYAVLADTPARVEKLTLDSRVVKSWECGKSAMHESLDKAWSNLKSLEVRETLSSDFSKGTAISHILQHAPELQSLSLNSLAADSKRSKIFRVASSASIKTNRLESLVLADLAVKPEDLTMWLTRFGSTLKTLELYSVLLADGSWKDVIQTIQDKCTNLQKVVVQYPQGAAQRGPFLDVTCSGSDLHSKLEQFKGSVAEAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPV6</accession>
    <name>A0A317WPV6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_465872</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467510.1">
        <property type="nucleotide sequence ID" value="XM_025608138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPV6"/>
    <dbReference type="STRING" id="1450535.A0A317WPV6"/>
    <dbReference type="GeneID" id="37110281"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="41"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY87302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="452" mass="51319" checksum="CBF243725124BE4E" modified="2018-10-10" version="1">MKPSKVRYECIDPDEVECLNCYVPGGYHPVQIGDEFHNRRYVIVHKLGFGRSATTWLAEDRQDSRRLVALKISTAESAERTVHESQVLTRLAQAKSQPGDTMVQTLFDSFSFSGPNGRHQCLVMDAARVNIDEAKEAAYHRLIHLPAARAIIAQLVLGVHFIHSQGIVHGDLHLGNVLLRLLPSLQRMTTKHLYDKIGEPTKAPVARCDGAPLDYGVPSELIIPLWLGLGSDEITLIDSPILITDFGEAFDPSVTKTFSCHTPHLLAPPEAFFAGPETDSHISFPADIWTLACSIWDVLGSAPPFEVFVPDLDSVTREHVETFGKLPDRWWRKWANRDNWFDEDGSKNVKEELRQLYSNSARNWDQRFLASIRGTRQRASRAEETDFGFLEQDEERAFGDMIQSMLVLEPAQRATIADVVRCEWMQRWWLHELQRMEDKVKKEKALFLPGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQB7</accession>
    <name>A0A317WQB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_490954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467958.1">
        <property type="nucleotide sequence ID" value="XM_025609138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQB7"/>
    <dbReference type="STRING" id="1450535.A0A317WQB7"/>
    <dbReference type="GeneID" id="37111281"/>
    <dbReference type="OrthoDB" id="2590398at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="628"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="732" mass="82305" checksum="1186F485E7E9CCE2" modified="2018-10-10" version="1">MSRKHARISVVEDVVIPAHLLAATTQVNGPWTTQGDEPSLSEPGPVQQAIRTEALERQYGRLRRSASVNSSQPEKPRDYHIRRQSAPLSVAEISTIGELEPHDYYNKESQHIQWQRSPGLDSGHTNARAQNERPIPTASVDGELPAGETAPTARGDAWPLPPRPNSYRLSRVEPTEEPQETKNPARHSIYDVYEKAKERRVALQRKYWVQLLFEYTVYVILVAFIYFVLVGMPLWRGAVWWLYWVVRTKFVIPGGWGITIGLSVLYAFTPLLVLFEKNPPPVDSNSTDEDLERNRNSAKSTALLIPCYKSAGIIGPTLEAALRIFPPENIFVIANGNSPEPLDNTEEVCRPFGVNHLWCPVGSKIIAQFVGCYAAKDFPHVLLIDDDCALPPNFPVVSDRLKGRIQSIGYTIKSVGPGSSRGTLCQQAQDLEYKISGLQRAFAGKLGSATFPHGAISLWRTDFLKQTFHDHPGFSVSEDWFFGDSCRRLGGRITMCSAVFVETETPSAVFFSSGGSRGGFGEMTIFKQRFTRWNFFFVNGMWYNMKYIVCSWNLGFWELGAKLFVFQEVYETLLYLLAPFMLPISLVVRPEFCGILLAITNGLYFLNVIIFNLVHLRLKKESVSWICLLFYYMPYKIVLFLINVVSCYWSLFKYARYFAARHPKVIEDDKAVEVVLRLEETTANAPKTTNKTSGLGRSFSVTKVRARRPSTAPKPSGPGGVSVAGIDESPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQV5</accession>
    <name>A0A317WQV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Cytochrome c oxidase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Cytochrome c oxidase polypeptide VIIA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_586135</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the fungal cytochrome c oxidase subunit 7a family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467141.1">
        <property type="nucleotide sequence ID" value="XM_025615742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQV5"/>
    <dbReference type="STRING" id="1450535.A0A317WQV5"/>
    <dbReference type="GeneID" id="37117885"/>
    <dbReference type="OrthoDB" id="2317211at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22888">
        <property type="entry name" value="CcO_VIIa_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014368">
        <property type="entry name" value="Cyt_c_oxidase_su7a_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28264">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000283">
        <property type="entry name" value="COX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR000283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY86550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="61" mass="7042" checksum="981E5887A07B690B" modified="2018-10-10" version="1">MAAVPPITGMLRRTLVLDLSTAFGFGTTFGYLWWYGFHLPRVRARDNYYTRLEAERAASQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WS47</accession>
    <name>A0A317WS47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_491464</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468217.1">
        <property type="nucleotide sequence ID" value="XM_025609154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WS47"/>
    <dbReference type="STRING" id="1450535.A0A317WS47"/>
    <dbReference type="GeneID" id="37111297"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016277826" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY88855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="379" mass="39830" checksum="4A2A43F1B4429285" modified="2018-10-10" version="1">MVTSSSLIAVGLTLWASLVSATPADPRVTAAPKLEDLDKRATSCTFSGSEGASSASKSKTSCSTIVLSDVAVPSGTTLDLTDLNEGTHVIFEGETTFGYEEWDGPLVSVSGTDITVTGADGAYLNGDGSRWWDDEGSNGGKTKPKFFYAHNMIDSTISGIYIQNSPVQVFSIDDSSYLTLEDITIDDSDGDDAGAANTDGFDIGSSTYITITGANVYNQDDCVAVNSGENIYFSGGVCSGGHGLSIGSVGGRDDNTVKNVTFYNSEIKSSQNGVRIKTIYGDTGSVSDITYEKITLSEITKYGIVVEQNYDDTSKSPTDGITIENFILDGVEGTVESSGTNIYIVCGSDSCTDWTWTTVDITGGKTSSDCENVPDDISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSF6</accession>
    <name>A0A317WSF6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_535231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467338.1">
        <property type="nucleotide sequence ID" value="XM_025611733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSF6"/>
    <dbReference type="STRING" id="1450535.A0A317WSF6"/>
    <dbReference type="GeneID" id="37113876"/>
    <dbReference type="OrthoDB" id="2326446at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23858" checksum="920E2F58762ADACA" modified="2018-10-10" version="1">MATLTPINLHHPPEYTLLQHHRTICGWHSTDDVLLSWREKQDAGLKSFFWITIPNPEPNESSTPIHAGHISLDSYADPPDPDLARADRSILTIQTFFILPEYRAGGLGREAMTLVEALATKEPYGSPRCEYLTVNTTSKGYYVDGAGEKRRQMLRVKQEEEGGFPVVLWYERLGYVWWKTEERYKYVDGEKGEEVWIEADFLRKRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTZ1</accession>
    <name>A0A317WTZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_534328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468466.1">
        <property type="nucleotide sequence ID" value="XM_025611519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTZ1"/>
    <dbReference type="GeneID" id="37113662"/>
    <dbReference type="OrthoDB" id="5397827at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="262" mass="30263" checksum="48002F9C910E9665" modified="2018-10-10" version="1">MPPVTIPQFLLPRGAPSPLTLRAALTRQTTYHITTQRCASSKPDNSHPRVLAKPDKFRPPSHPARRVVQTRNGKVVNSGPINYPGPKLSEKEKEEQKNRQYPHMFPPEGTVMHKFLTHRWIHIWIAMGVLTSLATFTFTTNFKRSSPFAHLLPPWSGLLAHPIDTIRQAVSVFRMHVEHNSMETREKRRRRVDDAEKRRQYRIAHGLEEPDERDEVKADEKEQVAVDDQSPVAVVQQAQDDKNVYVDWEGNKKPVKKWLGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WU38</accession>
    <name>A0A317WU38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_623590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468516.1">
        <property type="nucleotide sequence ID" value="XM_025617159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WU38"/>
    <dbReference type="STRING" id="1450535.A0A317WU38"/>
    <dbReference type="GeneID" id="37119302"/>
    <dbReference type="OrthoDB" id="3520229at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="164" mass="15986" checksum="63D34B1861B994D0" modified="2018-10-10" version="1">MSQISTVTVSAASPSSTCHQDLYSIPIKDAACAMPISGNNSAIMSSCCGSASVVSYDSCDYYCLAEDQTVHTLAECLIKASEAGEVWCNTNANATATGTVPATGAGTVVSTATATGKTKGSSTGTGTASGSTASSTSNAGVAVTKKSVGVLAVLVLGSVVGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUK7</accession>
    <name>A0A317WUK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_534275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468412.1">
        <property type="nucleotide sequence ID" value="XM_025611503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUK7"/>
    <dbReference type="STRING" id="1450535.A0A317WUK7"/>
    <dbReference type="GeneID" id="37113646"/>
    <dbReference type="OrthoDB" id="3533051at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22455" checksum="BD356CFB3AD1EB6D" modified="2018-10-10" version="1">MTPHILIISGTHVTGKDTIAASLSQTFNCPFLEGEYCYNAAWSIARAREKHGYDRSSVFGQTWLRKMSRIGLPLPSPPVSSTSPRSLSSSSSATSTNCKITAVISCAAMRKPSRDAIRAVMRAQSVGVIFVVLQIEPETLLGRTVGAENRELEMRILEEKTEDIRVPGVEEATRDTIVVDALMDVDSVCWVIQGRVWELFVHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WXH2</accession>
    <name>A0A317WXH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_584745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468399.1">
        <property type="nucleotide sequence ID" value="XM_025615650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WXH2"/>
    <dbReference type="GeneID" id="37117793"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016310997" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17133" checksum="F1D0EBF1024CD544" modified="2018-10-10" version="1">MNNWPGTIILPTLLHLHNLASTPAVSFLANKSTNSQTLSPSTSTNLNTLSISSSPNINPIFLTNFLLTSPLVLEFLAWPTGNSTSTSSNTLPPSTSPPPQPQYSSSRDPDNPSSTSHPPSPQSCSSTPPPPDPPPPRLIPIILHHQLPPFTNATDTTNSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY74</accession>
    <name>A0A317WY74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_533485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469082.1">
        <property type="nucleotide sequence ID" value="XM_025611344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY74"/>
    <dbReference type="STRING" id="1450535.A0A317WY74"/>
    <dbReference type="GeneID" id="37113487"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY91354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="661" mass="71697" checksum="9F377BF9B3E7D47A" modified="2018-10-10" version="1">MASSPLNHGPVNPPSSSESLPSTGSLPSPSASSSPSPPAPSSAAPPLSDPPPARPPLPRSATVGASLLREYALHIDPSHTTNDIHASDSAPGTADLCLETVQKPDIPREGAAVAPSPPPPSLPRRQTASLTGHHRNALSSDSIPRQTLLKALASRPSMCNQTSNMPLAATLGLLNTNPSPSDETERRSSNSSSQMLSAALSNIQLGTYLDRAPATARLVMQSPCFFHQRFDDAVNIQKVLEEIADDEWLSHSRLVQTATGVREVSKQLQRRPIKRAVRNVMIVTKARDNSLVHLTRELAEWLLYTPRYGKDIGVNVYVDAKLRNSKRFDAQGLLQKDPRFEKMLRYWTPDLCWTAPEKFDLVLTLGGDGTVLFTSWLFQRIVPPVLCFSLGSLGFLTNFEFENYKDHLNAVMGDVGMRVNLRMRFTCTVFRKDRSKGAEAGAVEEGEQFEVLNELVIDRGPSPYVSNLELYADNDLLTVVQADGCIFSTPTGSTAYSLSAGGSLIHPSIPGILLTPICPHTLSFRPMVLSDSLLLRIAVPAGSRSTAYCSFDGKGRVELRQGDYVTVEASQYPFPTVVAGSGEWFESVQRALRWNTRGAVQKSWHSASDAGLDPAEDEEDGEWDIDTDAGLTGTDSGLGVSEDGDTGSISPLKRQMSMFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ77</accession>
    <name>A0A317WZ77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_534070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468945.1">
        <property type="nucleotide sequence ID" value="XM_025611453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ77"/>
    <dbReference type="GeneID" id="37113596"/>
    <dbReference type="OrthoDB" id="10524893at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY90567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="116" mass="12638" checksum="91BF2AF5A1FF4CE4" modified="2018-10-10" version="1">MTRPPRSPRTNAFSLSSFASSAVAWLTSGGGMQGARHGQQCLQPGATDMHVSQCSASLGMPGQEGAVARQAVRHWRIHFIRTALTYRLLSFVWRLIPLSVDRSLGSRRPLSGDVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0G8</accession>
    <name>A0A317X0G8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_555611</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468846.1">
        <property type="nucleotide sequence ID" value="XM_025613814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0G8"/>
    <dbReference type="STRING" id="1450535.A0A317X0G8"/>
    <dbReference type="GeneID" id="37115957"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY90468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="335" mass="36511" checksum="25C294B40CD6BB7D" modified="2018-10-10" version="1">MASIVDFFSNVLFRPVESYCSFGPTVNELTLGLLGYSFKPEVDINDLSGKVVFVTGGNAGLGKETILQLARHHPSRIYLGARSAAKAEDAIASIRERVPSADIRHIYLDLTSFKSIRAAAKQFTSECDRLDILILNAGIMNTPPALTEDGFEIQFGTNHIGHFLLTELLFPTLQQTVALSSDVRVVTLASAANVSAPPFEIMTSTSALLASHTLTRYGASKAANILFASELARRHPEILSVAVHPGSVVSELWDHTSKISVMAKYSIATILAFSRSIRTGAFNQLWAAGAKRELLANGAYYVPIGVHAAGNRYAIDTDMARRLWEWTEKQIAERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1T6</accession>
    <name>A0A317X1T6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arp2/3 complex 20 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_623280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468888.1">
        <property type="nucleotide sequence ID" value="XM_025617139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1T6"/>
    <dbReference type="STRING" id="1450535.A0A317X1T6"/>
    <dbReference type="GeneID" id="37119282"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY90510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="206" mass="23542" checksum="A440E4C0CBF26F1C" modified="2018-10-10" version="1">MSKLILPAESCTSDAICPEDAIQHQQSGAPHLRHIPNMSQSLRPYLLAVRSSLTAALAISNFASQTSERHNVPEIEAATSPELLLNPLTISRNENEKVLIEPSVNSIRVSIRIKQADEIEHILVHKFTRFLTQRAESFFILRRKPVKGYDISFLITNFHTEQMLKHKLVDFIIQFMEEVDKEISEMKLFLNARARFVAESFLTPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2X3</accession>
    <name>A0A317X2X3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_615640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469745.1">
        <property type="nucleotide sequence ID" value="XM_025616764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2X3"/>
    <dbReference type="STRING" id="1450535.A0A317X2X3"/>
    <dbReference type="GeneID" id="37118907"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF27">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="236"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY92984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="400" mass="44029" checksum="310EC9BF012E97AF" modified="2018-10-10" version="1">MPLNPLSSIGLQTAVVVTTIGFTSAHSALRPGALLLAGICTGHCISTAIDYFIRSPWASLAGGYSVMLLLHFVDIGLLTRWEFPPTNRRDKIAAESSREHSQGVSIPSWADRLRFGISASINARCIGTPDQVRNIYPSHHQGRAAFLYRTAGFAILSYVFLDFFGIMEDPEIGNRFLVASRVPIFRRLSELTAEEVIIRILFTASTAVALVSIQGGIYNLFAFTSVLSGFSEPQEWPSFYGSLSDAYSLRRVWSRVWHQCNTHKFRAIARYLTRDVLGFSSGTLKGQYAQVLTVFAVSSVMHLLIDLSAGVSISKSGALQFFGTQALGIVVEDLVSRMYSALRGLSPNRSVSKGERFLGFLWVGGFLVWSLPSYIYPLLYRTNMGENDCVVPVSIIGSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X417</accession>
    <name>A0A317X417_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxaloacetate acetylhydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_533438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469028.1">
        <property type="nucleotide sequence ID" value="XM_025611331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X417"/>
    <dbReference type="STRING" id="1450535.A0A317X417"/>
    <dbReference type="GeneID" id="37113474"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY91300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="341" mass="37039" checksum="1EAC803394D06ABF" modified="2018-10-10" version="1" fragment="single">MKVDTPDSASTISMTNTITITVEQDGIYEVNGARQDPVINLQMVTGSSKLRKQLRDSDELIVCPGVYDGLSARIAINMGFKAMYMTGAGTTASRLGHADLGLAHLYDMRTNAEMIANLDPYGPPLIADMDHGYGGPLMVARSVQQYIQAGVAGFHIEDQIANKRCGHLAGKRVVSMDEYLTRIRAAKITKDRLRSDIVLIARTDALQQHGYDECIKRLKAARDIGADVGLLEGFTSKEMARRCVQDLAPWPLLLNMVENGAGPVISTAEAKEMGFRIMIFSFACITPAYMGITAALERLKKDGVVGLPEGMGPKKLFEVCGLMDSVRIDTEAGGMGLRMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4A7</accession>
    <name>A0A317X4A7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBA domain-containing protein Ucp14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_510868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470157.1">
        <property type="nucleotide sequence ID" value="XM_025609746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4A7"/>
    <dbReference type="STRING" id="1450535.A0A317X4A7"/>
    <dbReference type="GeneID" id="37111889"/>
    <dbReference type="OrthoDB" id="272778at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF21">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31173" checksum="6F046E190AE8F660" modified="2018-10-10" version="1">MITSGLTNAPISKSLLIYTITSSVALAIFDLKHLTNIHVAPHIWQYGQFWRILVWQVAGFANSTEALFAAMLVYHLRVVERAWGKRKFATFLLTTLPYATLLPPLLLILVLRPITLGKLNYLPSGPVATLFALLAQYHASIPHTFRYQISTASASPSTSTKDQPQPTSKFLTLSLSDKSTTYLVAAQLALSQFPAMVLPAAVGWLVGVAWRMEFLPGTGEWRVPAWVVGEKERMVVAGNGGGESGRYEDLRRRLEGEAMAASASASASSSAADASGEGAGQRRRNGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4B7</accession>
    <name>A0A317X4B7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_343809</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470235.1">
        <property type="nucleotide sequence ID" value="XM_025607057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4B7"/>
    <dbReference type="STRING" id="1450535.A0A317X4B7"/>
    <dbReference type="GeneID" id="37109200"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024325">
        <property type="entry name" value="DUF3835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039553">
        <property type="entry name" value="Prefoldin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12927">
        <property type="entry name" value="DUF3835"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13758">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3835" evidence="3">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3835" evidence="3">
        <location>
            <begin position="519"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="596" mass="65857" checksum="20141ACDE08D030D" modified="2018-10-10" version="1">MGVPNNGLHELERQRLELEGNISKLQDSLYHWRTWEAEYDGLREEINELGDDATIDDYIRVGRDFGGSLVNEEEVKVILGEKQGVTRTKQQVVDLVTRRIDYVKQNAATIEKRLRAAENEMYTLDSQDQLPAEPTADFPMTEIFEELDENGDVISSTTTTPGSQAPDLLQVLKKAGVKDIPDVVKADTSVPSSSQSTTQPTEEASTKDHISIVDEPSTSSSGSNDQEDKPAALDPTIEVHGERPVTEVDEPPEDAQLRREMLQYSLNEVGSVVAELELDEGASDISVDDEYDAYEFDDDDDEEEDEYGRSTGRVLSEDYHRQMRELEQKLNARGMWNAGKDTESLPTDVKQDLEQPIVVHVEKSADASSEPVENKKPKKKVAFADELDIAPAPKPPTIEKKAVPVRESNVPVLSDSVVERTGSVDKEPVQNAAPKKASRFKSARKTSATEEATASTSQSSGSTRPAEPRSALRKTEASSTVSSLPLFPAKPAEPKPFSQPISEVIGKDSTPRGPEGKILADTLVEREVPVGPAAAPEPDELDEQLHKKEIATEFYRIRNRMVQQNGGFMGEEPEIVPIETEDAPRRVSKFKAARTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4W3</accession>
    <name>A0A317X4W3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_459425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470415.1">
        <property type="nucleotide sequence ID" value="XM_025607841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4W3"/>
    <dbReference type="STRING" id="1450535.A0A317X4W3"/>
    <dbReference type="GeneID" id="37109984"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="80"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="510" mass="55673" checksum="2C84AE6FBFD74FB9" modified="2018-10-10" version="1">MAANGDFSDDESQPGSPILEANGHDDIEEQEPLDQPLKSAMKKEVPPPQPKRPELPEQPDPETLDLSTLTPLTPEIIARQATINIGTIGHVAHGKSTVVKAISEVQTVRFKNELERNITIKLGYANAKIYKCDNPECPRPTCFKSFKSEKEVDPPCERDGCAGRYRLLRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNENCPQPQTSEHLAAIEIMKLSHIIILQNKVDLMREDGALQHYQSILKFIRGTVADGSPIIPISAQLKYNIDAVNEYLVSHIPVPVRDFTASPHMMVIRSFDVNKPGAEIEELKGGVAGGSILTGVLKLDDEIEIRPGLVTKDENGKIQCRPIFSRVMSLFAEHNDLKFAVPGGLIGVGTRVDPTLCRADRLVGFVLGHRGRLPAIYTELEVNYFLLRRLLGVKTADGKQAKVAKLTKNEVLMVNIGSTATGAKVVGVKADAAKLSLTSPACTEIGEKIAISRRIEKHWRLIGWANIVAGNTLEPILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X511</accession>
    <name>A0A317X511_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_511466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470437.1">
        <property type="nucleotide sequence ID" value="XM_025609772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X511"/>
    <dbReference type="GeneID" id="37111915"/>
    <dbReference type="OrthoDB" id="4226789at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="750"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="782" mass="85399" checksum="5467D0C5A8997D4B" modified="2018-10-10" version="1">MAFFLICPRFRRYWKPSDSDTGRSYQLNPARPSPDGDPEGISSTREDAHSNHHRGSSGLSDRLRRRFSREAKDLRVKPRTQRKSGSPGFPFSSKLANTSKGVSTPDDIGSSLMSERGYDSDAQFISTPKQISHTRDHPTNTRIVQETVSPLRQEIEREESYEQGHGLESEAMANARVDRAVMEEPQPTFHSRNQTSWATQSSGSSAFRADDGSRRARVARPQRGVGGSPVQSKRNGPVYPQQGYRPPLRMATPDPGIPRHGSGYSSPISPVPFPYTTSADSLAGPSQISVRKRRRQPPTGTMSDNCSIHLGDMNIPTMLASCSTSPRILSPKHSFDENRWASNAGTWNAPQPSYDSSGDAPGNTLFSHTTGPRFRRAPVDQSSSCYSPKTSLSSTGIPIDSANKRNYQPTTKELIAEPIAGFNCSPGSFLVDPHHTSAVDSYDTKKVESQKSKFTERFEQDRSMASLGHGLHGSDTDPASPRKVSVGWMSGGRRLGYGYTMVPANDGIDQPSGSPKPGETGMSEMAAINAGSQGDLLRRVESGSTGQTRKTSPRTGDPSFDISSIMSRMRLRSLSSALSEAGSDSIKFSLLEKLKRKKDQGDEVADAKNPWDFCSWVDPNQPVSGQSSPQKSSSVSTKSTEGRPVGRWATLRRTGSLLTKGRSVSAITRGLEAKAITRMTTPAGRYPVARRKEGRMLKFKVLDRKKKARSADDNVPIVPMAQSHGSADSGECQDGHVDKEQMIDTGAGMAERDRHRSSDKTGSDAITDDWKSTYQDCQEMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5J3</accession>
    <name>A0A317X5J3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_312016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470637.1">
        <property type="nucleotide sequence ID" value="XM_025606830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5J3"/>
    <dbReference type="GeneID" id="37108973"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="83" mass="9083" checksum="8515D41A0D60CCC4" modified="2018-10-10" version="1">MGVVGRNSIALNDNVNIAAWFTRRISECRLYLFMTVPVCFITCGILFGVGAGAMLSLHEIIYQLAAKMKDSLAQNSTETPTVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5Z7</accession>
    <name>A0A317X5Z7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_582989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470372.1">
        <property type="nucleotide sequence ID" value="XM_025615521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5Z7"/>
    <dbReference type="GeneID" id="37117664"/>
    <dbReference type="OrthoDB" id="4187771at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="149" mass="15513" checksum="A251F32AB93DFEBA" modified="2018-10-10" version="1">MRVLHSFNRLLRNFLVIGLLASVLTSAYLDSFLRGIQSNLLKRSIPASLATAPQGAVGYYQPPPGPAVNYPYQLQTTSAPSATTTGGTVLPTGGNSGTNGPRKNIALVSGTVTGTHVIIEATQSAMANRDLTLGSGGFLLSILLGILQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X677</accession>
    <name>A0A317X677_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="5">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_583171</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470576.1">
        <property type="nucleotide sequence ID" value="XM_025615538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X677"/>
    <dbReference type="GeneID" id="37117681"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000004">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="713"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="800"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="840"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY93815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1171" mass="129279" checksum="83C1A6FBDE82D031" modified="2018-10-10" version="1">MDAKVKQHYLADSPPTVVRLEVKSHFDNLKDQKLRKYAHYLSRAAFEGARITLRQVSPESEPIYDLIIELHRACDGNWTDLARKTGVSDENLRFFLEYAAQFLGNCGNYKGFGDSKFIPRLPVEAFQALASLTPKTRAAFALANTSGGGIYETDVQSRMHLGYSEGEHMTTYYPDSPSITKDEITAVSDLMEQKGLPLENTRLRKTESGDFELLIASGVSSPPARDRDLGEAEALELDGKLEGKKLRIVFGDHREEMAKIAHSVKQAGLHAANDNQKRMLDAYAMSFGSGSIEAFKESQRIWVKDQKPALETNLGFVETYRDPHGVRGEWEGFVALVNLERTRAFGKLVDSAEAMIPKLPWGQDFEKDKFLSPDFTSLEVLSFQSSGIPAGINLPNYDDIRQNLGFKNVSLGNVLSAKAPNEPVPFIADKDLEVYRNCRDAAFEVQVGIHELLGHGTGKLLQETAPGEYNFDISNPPISPVTNKPIASWYKPGQTWGSVFGALSSSYEECRAECVAMVLSCDFSILKLFGFGDGKEDLGSDAGDVLFAGYLQMARAGLVALEFWDPKTQKWGQAHMQARYSILRTFLEAGDDFVKLSYGEEDLSDLEIHLDRSKILTHGRPAVEKYLQKLHVYKSTADFEAGKKLYDDITSVDEWWGTKVREIVLKNKIPRKVFVQGNTILNGDEVTLKENPGSGFPPAKALSVEFTKLPTITKDKTAIPQHRHINPDALSWSPNSSGSPATARPYLTDSVAEEDDDDFYTAPPPPHSPYSEASSSLSSSRPPPFSSLVFAPATEFNRGKVTFSPPESASAPTSVPLPPDEEPLEPSPSSSLVAETKASFSRDQKSESPGKSTDEGEPPPPYTEGSSPIESFTYVMAAAGGASSIITQVQQTGGPPINTLGDIGGDEHITLDLRGTRFTLSRDELLTLPEFVLLSLFPNGLLPDGHMGTFHEGDIYPVDYDPASLQYMLDFFRSVAQSIPSSSPSASTSPDLDVAPDSMQGTARDMLQDRAGIIVLREDLDFYAIPPRPDIEHTEMIEVKRAAARALLKQDGIFSGLRKSDEVGSTEQHLIEMLTAGGFDRDDRWGHRAPEPNKAVICSLALAKLRTDIRGDISNNNAVGMAQKLLLFWRKPARRCWWEGIELDDVEGVEGKVKIWIRRVWTLEMSVIGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X742</accession>
    <name>A0A317X742_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_543267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470762.1">
        <property type="nucleotide sequence ID" value="XM_025613131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X742"/>
    <dbReference type="STRING" id="1450535.A0A317X742"/>
    <dbReference type="GeneID" id="37115274"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="241"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="335" mass="38929" checksum="A5E90640C85212D3" modified="2018-10-10" version="1">MPESRDDYGRRRHRSPSGSPAPDRDRRQRLRDDDDRGSGSGRRNSYRSSRRDSSRKRSSRSPTDRGSHRRDHDRRRRERREQEDASDDDKRRRRHTSDRDSSHRRHRDRDSYDRKERSSRRRRHDSRSRSPARRSQSPVSQAPVRSKQPLPPQNDAYTSSEVTRTGESAGPPPEKEKPNFGQTGRLAAESNTVNVNGSSIVLKYHEPPEARKPPAKEPWRLYVFKGKDLLEMVELGIRSCWLIGREQMVVDFPLEHPSCSKQHAALQFRFVEKRNEFGDRIGRVKPYLIDLESANGTSVNGDAIPAGRYVELRDKDVLQFGLSSREYVLMLPQPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7E4</accession>
    <name>A0A317X7E4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_486775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470313.1">
        <property type="nucleotide sequence ID" value="XM_025609018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7E4"/>
    <dbReference type="STRING" id="1450535.A0A317X7E4"/>
    <dbReference type="GeneID" id="37111161"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF5">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="443"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="655" mass="71679" checksum="181D274F2E7D6C9B" modified="2018-10-10" version="1">MTSPIPAPFGTWESPITPETVTSQGITFSAVATTPDGTIYVAEGRPAEEGRCCIVEWRNGEPRDVLPKEYSARTAVHGYGGGAFATISNGNIVFHDWKTHGVYVLDPAAGSVTTAVEPDPKIYYADFNAHPQKPECILAIREDQRSGEVINELVLINSVEKTVKVVVSGADFYSHARFNPAGDRVSWIQWNHPDMPWTGTEVFVASWVDGALEKPVKLAGQAGEESITQPRWGPDGTLFFVSDRSGYWQFYQWSPDSDKPRAIVIEGLEKGEFGHPDWFLASCTYVLPNPDTIVGAWTHEAAERLVIIDLKTNTYTFPSHVAPLTGIRDSSVALTSPTSIAVIASTPTSPSTVYHVSLTTDTTPTILRSSTNLTIPESFYSHAKHISFPRTTPTHLDTQSHAFFLPPTNPNYTSPPGKLPPLIISIHGGPTAHSDPGLTMMWQYYTTRGYAVAFLNYAGSSGYGRAYRTLLNGSWGLLDVHDAADCARYLISTGQVHPSHVGITGGSSGGYAALQAICDFPSLWAAAISISGISDVEALVADTHKFESHYAFRLLFDDNVPQTEEEKRTVYRARSPRFKAENIKAMTLLLQGTEDEIVPLNQAQAMADDVQRSGGVAKLVIFEGEGHGFPRKAENGLQAMKEEEDWWRESLGEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X871</accession>
    <name>A0A317X871_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAGA complex component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_531739</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471565.1">
        <property type="nucleotide sequence ID" value="XM_025610966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X871"/>
    <dbReference type="STRING" id="1450535.A0A317X871"/>
    <dbReference type="GeneID" id="37113109"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20394">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000055">
        <property type="entry name" value="SAGA complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047287">
        <property type="entry name" value="Tudor_SGF29_rpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="6">
        <location>
            <begin position="347"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="481" mass="52005" checksum="8AFD33635828B995" modified="2018-10-10" version="1">MTSANQKVHGAAKRLPPSREGKLSAQVRSPNDGVPEAEAQVPVSPSQSAGPDRLSTPENPFAANPQSPSAAGRPHNLRQGAARGTRSSARKDLLSAFEWEALDIQNTRSSAAVAIPAKTSNRRPRKAEAAAAATAVTATADPTSPPKKMSRNRPRGPPVPRDNGLAANEETDMWNKILQDLRKAKEKNEKQKVLAEQIAALNEKIGREGGRPSLSEHNQLDSLYRQMLKLCEDERAILQDEPSDVIKNLGLLTALRQASEAEAPQNRATSFSKSRKKRNDLDGSATDSPGPSGNALPDKVGRTKGGVQRSTSVSSTQVRDGRDIRDSGVYVKIEEGAESTKGAIAERSGHLVVGAEVVFKHNKNKQGVEGEGIQCIIKGISGDGVKKRYDVQDPEPNENGEQGAVYKTTAASLIPIPQMGSILPSFALGKQVLARYPDTTTFYRAEVMGSRKDVYRLKFEGEEDDKEMEVDRRFVLDIPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9T6</accession>
    <name>A0A317X9T6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_532599</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470429.1">
        <property type="nucleotide sequence ID" value="XM_025611153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9T6"/>
    <dbReference type="STRING" id="1450535.A0A317X9T6"/>
    <dbReference type="GeneID" id="37113296"/>
    <dbReference type="OrthoDB" id="9616667at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000003">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="89" mass="10169" checksum="E4408B890644FAD4" modified="2018-10-10" version="1" fragment="single">KTTPLNTPKTRISRTKGQSSRRTAFVREIAREVVGLAPYERRIIELLRNAQDKRARKLAKKRLGTFGRGKAKVEDMQRVIAEARRTGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9U1</accession>
    <name>A0A317X9U1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_507816</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471742.1">
        <property type="nucleotide sequence ID" value="XM_025609635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9U1"/>
    <dbReference type="STRING" id="1450535.A0A317X9U1"/>
    <dbReference type="GeneID" id="37111778"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="218"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="530" mass="58960" checksum="AD06B5EF836DDC08" modified="2018-10-10" version="1">MTKPDEKPEQDSGPPPDHVSNLQPSPRIIHFAGWEIGNLLVDPAIPSLLPEGLHWIQSRTGAVIPLPRLSHAPWEKAPPTCTVGRAVIPPLAELPMKSVLKQYLDVYHSSRIRMIFPVVDSSLFLQTMEAAYSLHGQQTQRCCAAACIFAFMALVSSMDHVAIGCTAPRPPPISRMAYVENARALMPYMVQNSLNLDAIQTALLLAINGTLIGELQTAIHLTSIAARQIMAVGAHTCSEPHGNEAHHLRTLFWICYALDKDLSLRTGQPHCLRSDDCNLQLPTAYVEQLGSRMAYSPRSNHPEGPLFPVDLRLSMIKSRIFTALYSYSGLCKSDVEIIRSIRELDDELEQWRTSIPAPVRPQLSFAHQLDATAPKNMFLVLTHLDYYSCVNLIHLAGGRCQAWRSTTTPSGMMDGLRLSLTFSVEASRSLLLFLYDSESIVSAGSFWTLLFYPMSAILTIFCNIVENRHMNTAKRDIQLLEAAEHTTEKLFLRQSLRADKLVELQPVTRFISSLKEFAQQAVGAALNPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9U6</accession>
    <name>A0A317X9U6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_224775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472075.1">
        <property type="nucleotide sequence ID" value="XM_025606246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9U6"/>
    <dbReference type="GeneID" id="37108389"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="88" mass="10096" checksum="CD293B7B865D7CEC" modified="2018-10-10" version="1">MQHPSSSSPCSSSYHPRPCLFLPCYILRLCIRNWDPRQKRLAFCMIWTLLVRSSLLLLYSSWFAFGDLLVSLGNGPVEFRGGSKEQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA03</accession>
    <name>A0A317XA03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_606167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471802.1">
        <property type="nucleotide sequence ID" value="XM_025616511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA03"/>
    <dbReference type="STRING" id="1450535.A0A317XA03"/>
    <dbReference type="GeneID" id="37118654"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="318" mass="34366" checksum="5E4E2BF77CE17C58" modified="2018-10-10" version="1">MTTRYEAVHKKPQGPGDARPTAMQIIHDESLEGQLTGLPILITGASAGIGVETAKALFPTGATLYLTACDLNKATQALGNDLSPPHAVRTCASNLLSKTQTLNILIANAGIMATPEGRTKDNNELQFGTNYLSLFLLFLILRPALLSAATPKLPSRVILLSSIAHRSSEVNFSNINLDNEYEKWKAYAQSKCAMLWTANEIDRRYAAQNLRAFSVQPGGIQTGLLKHMSEEEKTGLTSDPKLGPQIKSPEQGAATTLWGAISKSLHGVGGRYLEDVQIAKPFDASEGHWAPGYSPHAYSPEKEKMLWEVSLGLVGVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB76</accession>
    <name>A0A317XB76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_139650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472645.1">
        <property type="nucleotide sequence ID" value="XM_025605716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB76"/>
    <dbReference type="STRING" id="1450535.A0A317XB76"/>
    <dbReference type="GeneID" id="37107859"/>
    <dbReference type="OrthoDB" id="10255630at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="190"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="352" mass="38954" checksum="CFF83FDB4014BC64" modified="2018-10-10" version="1">MADMTGEQMQAKITAARREAEGLKDKIKRRKDELADTTLRQVAQNQTETLPRIGMKPRRTLKGHLAKIYAMHWSTDRRHLVSASQDGKLIIWDAYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLSSREGPTRVARELSGHSGYLSCCRFINDRRIITSSGDMTCMLWDIESGSKVTEFADHLGDVMSISINPTNQNIFVSGACDAFAKLWDIRTGKAVQTFAGHESDINAIQFFPDGNAFGTGSDDTSCRLFDIRADRELNTYQSDQILCGITSVAFSVSGRLLFAGYDDFECKVWDVLRGDKVGSLSGHENRVSCLGVSNDGISLCTGSWDSLLKVWAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCC2</accession>
    <name>A0A317XCC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_135745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472522.1">
        <property type="nucleotide sequence ID" value="XM_025605694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCC2"/>
    <dbReference type="GeneID" id="37107837"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="127" mass="14414" checksum="376C232751E1BC3D" modified="2018-10-10" version="1">MVSILTQIRLQEGTVVNIHRATTLIQQLETPPTENTDREYTRLGAPQRPRGVPSATCTAYGYIMVHREQPPRCGTRSHEIHYALWQQTHGACGLRDIPVMAWADEQIYGIEHDKMITHEIAGSEIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCW9</accession>
    <name>A0A317XCW9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_457820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471151.1">
        <property type="nucleotide sequence ID" value="XM_025607763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCW9"/>
    <dbReference type="STRING" id="1450535.A0A317XCW9"/>
    <dbReference type="GeneID" id="37109906"/>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF14">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016314724" evidence="5">
        <location>
            <begin position="20"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="366" mass="39816" checksum="6F193D8C8842B612" modified="2018-10-10" version="1">MKRLIQLVAVLLFSYVANALPYDADNHADRRDLATSSDTEAANVIVWVDQDGHVLASNAADSNQGPTATGSNSPTSLPPLLPILDDDVPFQLSPALPVSEPSNRPQTGNDRLFGISYSPYNDDGTCKTQDQVNKDLDRLTQYAFVRIYGVDCDQTKKVTTAARQRNLKVFAGVFNLQNFPASLDYITGAAAGDWSVFHTITIGNELVNKGQSSVADVVNAVNTARKRLRAVGYRGSVVTVDTFSVMLQHPELCVVSDYCAANCHAFFDANNTPDQAGQYVKNQAAQISKAAHNKKTLITESGWPHAGQPNGKAVPSPENQQKALASLKQAFTDSDQLVLFTAFDDQWKQDSSGTYGAEKYWGIEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCX5</accession>
    <name>A0A317XCX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_507444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472742.1">
        <property type="nucleotide sequence ID" value="XM_025609613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCX5"/>
    <dbReference type="STRING" id="1450535.A0A317XCX5"/>
    <dbReference type="GeneID" id="37111756"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="5"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="233" mass="24358" checksum="30C5D22B3EB12901" modified="2018-10-10" version="1">MPPTILFVPGFWEGPTVFDPISTILTAHGFITETAILPSTGTTSPGNPSMADDIASVRAHLQKIVQRGEEVILVLHSAGGFLGSAAMEGLAKADVGSGGGVVKIVFLSGAVFPVGFEHQPLPFGVTEGGAMYCAQPEVLLLDDVPEPEKTKWLGVLKPQPAQGWDGIVPYAGWQDVPSVYLICEGDRALPVGLQEQLAGLAGSQVERCSAGHLPQVSQQERVVEVIEAAAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD40</accession>
    <name>A0A317XD40_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_454632</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472268.1">
        <property type="nucleotide sequence ID" value="XM_025607614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD40"/>
    <dbReference type="STRING" id="1450535.A0A317XD40"/>
    <dbReference type="GeneID" id="37109757"/>
    <dbReference type="OrthoDB" id="4236860at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF4">
        <property type="entry name" value="ACETAMIDASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="631"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="680"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="779" mass="88244" checksum="D02E34F9018A872E" modified="2018-10-10" version="1">MSSVAHHSHPPTGNGVTKRKSGAAACVHCHRRKVRCDARIVGLPCSNCRSAGKSDCRIHEKKKRLTVRSILDPVPIRCRPPPASESTHKPSPVTATTPPSAFTTAFRAVQPEVTTPIAPPTSSLHTLHHTLNHNVNHHPPHHGTRPTTESPAYSRPSGPDVSTEPDSHAELEKRLVKLIDEEESGSREIQRGVRAIYVGHELSNMSFLIRQQRDKDDDVYHFAGNEIPRRQLRTGHDQLLMDALTLPEPVLADELVQAYFDHVNPGYPIVDEDLFMAQYRNRDPADPPPILLLQTILLVGAHVTRPKAERDTLKDIFFRRAKWLFDSRIERNRDILVQAALLMTWHSDGADDDVAANAHYWVGVAARIATGLGMHRNPVSSRFVSRDRRMWRRLWHILVQFDVMVSLSYGRPQAINLEDCDVSSLTVSDFEGCGPRVQSDYVIHFSELSVMISYIIRNRFGLRVSAERRKAVLQEADEALANWSLKLPDKLRLRASDMDPWSAMLHLTYNNFLILLHRPHPRASAYSDDYGPHDAEICSAAAGVITSIFEELRLNDRLKFLWYSGVHTLFTAMIQVRVELRFSNPVLAINALRRFDSASYSLRELAGYWFHASTILRLFEDSKRLQEDLRMATSERPRRFSNPQDQIKNTHHSSSASTSTVTTTMQTPQPADRPLPYEVPTPDSTHLTTTSTSPHHPQPHQVDTWIPPPFTTMTPVVEAIDAPRGSLDWRQLFSFADLDQPVLPMAMEGLPELEDEWRQIYWQDAPMSDLLQDGGWMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD55</accession>
    <name>A0A317XD55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_506544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472288.1">
        <property type="nucleotide sequence ID" value="XM_025609576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD55"/>
    <dbReference type="STRING" id="1450535.A0A317XD55"/>
    <dbReference type="GeneID" id="37111719"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006452">
        <property type="term" value="P:translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="85"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17560" checksum="922B5689116F1CA1" modified="2018-10-10" version="1">MADEHHETFESADAGASATYPMQCSALRKNGHVVIKNRPCKIVDMSTSKTGKHGHAKVHIVAIDIFTGKKLEDLSPSTHNMDVPNVYRKEYQLLDVTDDDFLSLMDESGGTKDDVKLPDGDVGERIIKMFRDEEKDCNVTILSSMGEQCCMEVKEAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD68</accession>
    <name>A0A317XD68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_580315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473230.1">
        <property type="nucleotide sequence ID" value="XM_025615318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD68"/>
    <dbReference type="GeneID" id="37117461"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="113" mass="13358" checksum="23F3EB3CBFE97B0B" modified="2018-10-10" version="1">MSQSPDQIIRPTLFLKKREDITHEQFHHHWTTSMQQLLHHLQLYVPSLECFTNALDDPYYKEVVALDEEKFISAKSCMRTVGYEECFILNDQVENPLLTGRSSIQDCRGPWCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDA4</accession>
    <name>A0A317XDA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_531829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471639.1">
        <property type="nucleotide sequence ID" value="XM_025610986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDA4"/>
    <dbReference type="STRING" id="1450535.A0A317XDA4"/>
    <dbReference type="GeneID" id="37113129"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000008">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="369"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="246"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="359"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="528" mass="56820" checksum="F2B3E42D4ED24CD6" modified="2018-10-10" version="1">MATGSHMHNLTTLIKRLEAATSRLEDMAMSLDDPNSPKTIAPAAVPESAAPEPPKPAPPAAPAAAPVPPQIQDFNTLINEDVRNFVELGAKIDGLVGEQSKMVLQAFEAERTYLLVSTKARKPEQQPPELMTELHNASDSINNIRESNRASALFNHLSAVAEGIVALGWFFADKPADFVTEMAGGAEYYGNKVLKDYKEKDRTHVQYIQAYYQIYKSLAAYLKKHYPKGLTWNNTNGIDAQEALRQVKGGSSNPPSSSTAPPPPPPPPVPTLNVPGGVPPPPPPPPGVAPAAAPAAPDMSAVFDQLNQGESVTSGLRKVDRSEMTHKNPSLRASSVVPDSPTSQGSAIRGKSPAPNKKPKPESMRVRKPPRKDLEGNKWFIENFDNPGEIVEINAQQNHSILISRCNKTIIKVNNKANAISIDNCTGLSIIVDSLVSSLDVIKSPKFALQVDGVVPTLLLDQVDGATVYLGQQSLATEVFSSKCTAVNIMLPPKEGTDEDTKECTIPEQIKTYVKNGVLVNEIVEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDJ2</accession>
    <name>A0A317XDJ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_530061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473447.1">
        <property type="nucleotide sequence ID" value="XM_025610598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDJ2"/>
    <dbReference type="GeneID" id="37112741"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="103" mass="11518" checksum="14740EF609260D6D" modified="2018-10-10" version="1">MKPPFLTVAIYHPRYGNFQHWALHLHSDTEDLIFEVDGEHPSFQKVVSRGLPSDNLGFIESVFVCQIGRPDIPTVKTVVNATLVDNETLEWDCQDCAGYSGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDN8</accession>
    <name>A0A317XDN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NACHT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_562110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473497.1">
        <property type="nucleotide sequence ID" value="XM_025614268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDN8"/>
    <dbReference type="STRING" id="1450535.A0A317XDN8"/>
    <dbReference type="GeneID" id="37116411"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="280"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1037"/>
            <end position="1072"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY96736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1109" mass="127316" checksum="385594E531B2C946" modified="2018-10-10" version="1">MAAVQSVIQKAFQTAMHDFKMNLNNDEIHAQILLVTSIEGVYDLTDKLQAEQGRKGHLRHLAKIEPYLNRLREYTAAIELFVQIEPEIMALIWGPIKLLLQWTSVPTQSFDAILNTTADIGLLLPEFQEVAVLFSRNDKIYDVLVLFFRDILDFYQICLQFFIMPRWKYFFESLWPRKRDHIDMVKAHIQRHTSLMRNEVRLEHIREEHDARLRALEHYKKSERADRLQKYQALKTEINPRTYDDKLNWYHGRVCKGTGGWLRQDDTFKRWLDTGNRTSRVLWLQGIPGAGKTFLAGTVVDIARTASHTAFAFLSHTFRSNTSALSVLHSLIFQLASQHDDLQDVLCHSAHEHIKSNVTVAVALLKEVLGCAGTAFLVIDGVDEIDEIERGVLLKQLLLLSQECQETRILISSRQEVDITAILQPTSEVIRVDDRNEESIQIYVNHQLEQLFESRSFPPSMQDKISDSLTLLASKAKGMFLYATVVLSSIELVDDATEICEELSTLPEDLDDAYSRVLLRINKLRPSVRDKARRILAWVGCSPTPLTLPELEQALTIQPCSLELLERDYVSPNLNKLCGPIIEVVDGYIQFVHFKVKEYFFSPSVDGHIDLVNGTLDLAVCCTTYLCQRQYDVDVRSNGITSVLLNGSYRLHYLAVNCWFDLIRDYLKLSRDEVLPTQLAECLRSLMTKRSNVEFAADRDTFTTPGYLQSIKKEYPDIYDFLSDVAQFRQRCLETGYRISDGKLWINLDPLSIFHQMNRILCNYSRHKRQCDCHLIERDFGKRPFRCGFLNCSFQQYGFESRAERDRHESKHTLPWKCSVSGCEYETTGDQHMKKAHRDKMPEWLITKDIVEWRELRSLLHDLIKQNELGMVELLLPGLHDSDSYFLADVVGRYGSIQMAQVVFERAKRYEVMSRAITAQNIELVKWLIDSGNTPEYDHGFYIATFVKTDSEEMYRLCERYTAAALVGYKALNATNKILSREKFLTSLWNFMGLGRELKPTRLTLALSSIARSSCSICLAAGLIQHGADVKGSKSPSAISPLHYAARKSSAENAEFMKFPLFAGADPDRVSRKRKPSDDIDAQGISRWLGISWGELVAQTRNHRRGLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDS0</accession>
    <name>A0A317XDS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_453082</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473537.1">
        <property type="nucleotide sequence ID" value="XM_025607549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDS0"/>
    <dbReference type="STRING" id="1450535.A0A317XDS0"/>
    <dbReference type="GeneID" id="37109692"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF57">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY96776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="728" mass="81970" checksum="699A656805B302C3" modified="2018-10-10" version="1">MTPRPTNSPSSLHFHIRSCSSCRQRKVKCDRQQPCTNCIRSGVECVYPPGRGRAPKRPRGALNAQLSQRLSRLETIIRSFETSENQRGSAPNSMEPTLRSSTTESGASQDHRLRPGPYTSSLDAELSIEQRLGRLLINETQSYYVSNVLWANLGDEIAELRDLLHEPELEEDDNALSEGSVLERPLPSGSNAAILGFRALAHSLRPYHPPLAQSVKLFELFRENVAPMVRIFHMPTLAQGHWDAIASLESLGRETEALLFAIYYSTVISMDSEQSMSTLGVSKAYASETYLFATEQALARADLLNTQSVTLLQAAVLFLFALRNEDDSRTVWSLTSLIFHIAQAMGLHRDGIVFGLKPMETELRRRLWWHICLLDARSSEYHGCEPIVRDSAFDTKLPLNIEDSDLTAEMTEPPVEREGATDMYFCLIRCEVMRTMWKLSCVSLSMGSPGLSTGRLSLEEREALVQKLHDRLETRYLKNCDISKPFFLASTFVARLMVARAWLIARYPLGEKECGVNLSGPVRDHLFSSSVEVLKLSSLVLTNEQIAHWSWHSKTHIQWHAVAFVLSEICTRPPSTDCDRAWEYVNIIYNNWKMKESGRKGTLWRPIRRLMAKAQYVREMQKLDPLGRWKRRVAPTDEIIQAVPGPETSSGTGMVYDLACPGMGDLPSSLLMESLDPLQELFPGVPHTEGSVDERENIVGSMLHLDAYSQIPGWLVPEWISEPPGDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDX1</accession>
    <name>A0A317XDX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_531664</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471491.1">
        <property type="nucleotide sequence ID" value="XM_025610948.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XDX1"/>
    <dbReference type="GeneID" id="37113091"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02735">
        <property type="entry name" value="RNAP_I_Rpa1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2850">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047107">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="364"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1345"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1375"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1397"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1423"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1441"/>
            <end position="1454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY94730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1679" mass="186695" checksum="12FAC913C0A2BFA3" modified="2018-10-10" version="1">MTTFARPVASSIAGIDFGVYNDEDIKAISVKRIHNTPTLDSFNNPVPGGLYDPAMGAWGDHVCTTCRQTSWSCTGHPGHIELPVHVYNVTHFDQLYRLLKGQCVYCHRFQMTRFNINTYTCKLRLLQYGLVDEVAVIDSMAHKKVEKKKSAKDGEGSSSEDEDDDDIIERRNTYVKKCIRQAQADGRLKGLMAGAKNPLAAEQRRVLVREFFKDIGSPSKCASCSGISPSYRKDRSSKIFRKALTEKSRHLMAQAGFQIPNSLVLLQQAKKLTSKEKEALANGVSDSHSTTSEIHGAEEEVARGNAIVAQAESKKQAPGESQQFMPSPEVHATMSLLFEKEEEILSLVYNSRPLPKKESRVSADMFFIKNILVPPNKFRPAAPQGPGQILEAQQNQSLTSILKNCDIINQISKERQSAGADSATRVRDYRDLLHSIVTLQDTVNMLIDRDRGNATGPAAAAAPMGIKQYLEKKEGLFRKNMMGKRVNFAARSVISPDPNIETNEIGVPLVFAKKLTYPEPVTNHNFWEMKQAVINGPDKYPGASAIENEFGQVTNLRFKSLDERTALANQLLAPSNWRMKGSRNKKVYRHLTTGDVVLMNRQPTLHKPSIMGHKARVLPNERTIRMHYANCNTYNADFDGDEMNMHFPQNELARSEAMMLADADHQYLVATSGKPLRGLIQDHISMGTWFTCRDSFFDEDDYHQLLYNCLRPENSHTITDRIQTVAPAMIRPKRLWTGKQVITTILKNIMPSDRAGLNLKSKSSTPGDRWGEGNEEGEVIFKDGEMLCGILDKKQIGPTAGGLVDAIHEIYGHTIAGRLMSILGRLLTRVLNMRAFTCGIDDLRLTAEGDRVRKEKISEAAAIGREVALKYVTLDQTTVPDEDAELRRRMEEVLRDDEKQGGLDSVSNARTAKLSTEITKACLPGGLVKPFPWNQMQSMTISGAKGSSVNANLISCNLGQQVLEGRRVPVMVSGKTLPSFRAFDTNPMAGGYVCGRFLTGIKPQEYYFHAMAGREGLIDTAVKTSRSGYLQRCLIKGMEGLRAEYDSSVREATDGSIVQFLYGEDGLDITKQVHLKDFDFLASNYVSIMAQVNLTSDFHNLEKEEVTNWHKDAMKKVRKTGKFEAMDPVLSHYHPGGNLGSISESFSQELKQYEDANKSKLLKDKKKDVNGIISKKAFNTLMHMKYMKSVVEPGEAIGIVAGQSIGEPSTQMTLNTFHLAGHSAKNVTLGIPRLREIVMTASAHIMTPTMTLVLNEEMSKEHSEKFSKAISKLSIAEVVDKVQVRERVSSGSMKAKVYDIDITFFPADEYTAEYAITTKDVQNTLQNKFIPKLVKLTKAELKKRHEEKTMKKFSTAQPEIGVSVGTVQDAPRGDDAEEDAADDDNEDDEDDAKRARGTQNRSNQVSYEGPEDEEMEMIRQQDAEEDDDEDDNDTGEKRDVEMDDASDDESEDDTKDTKLREEDIKGKYHEVTQFKFNPRDGGSCTVQLQYDISTPKLLLLPLVEDAARSAVIQSIPGLGNCTFVEADPIKGEPAHVITEGVNLLAMRDYQDIIKPHSLYTNSIHDMLTLYGVEAARASIVKEMSDVFQGHSISVDNRHLNLIGDVMTQSGGFRPFNRNGLVKDGSSPLAKMSFETTVGYLKEAVVERDFDNLKSPSARIVVGRTGTVGTGAFDVLAPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE19</accession>
    <name>A0A317XE19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_582179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471551.1">
        <property type="nucleotide sequence ID" value="XM_025615461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE19"/>
    <dbReference type="GeneID" id="37117604"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="8">
        <location>
            <begin position="140"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="285" mass="30664" checksum="E6F73D76AF9496CC" modified="2018-10-10" version="1">MESSDLTAPNARQANASSPTHRSSSPHSSHNEPRRMSPLSAKRQAAAVPGQRQSHPVNEATPIVSNSDTSRRNYHSTDGLRNRDSGTVNGHPDNPAHQASRDPDQQNPQPDSEEHRGSWYSRIADRYGSLELENKGSVARDHLALERTFLAWLRTSLAFASIGIAVTQLFRLNSAGSSTNTADFTAQGFSPLLSSPAYDPAAIRITSASSRLRSIGKPLGTTFIGVAILILLVGFHRYFESQYWIIRGKFPASRGSVALTAFVAAGLIITALVVILAISPGAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEV8</accession>
    <name>A0A317XEV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent L-serine/L-allo-threonine dehydrogenase ydfG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_3233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472988.1">
        <property type="nucleotide sequence ID" value="XM_025606914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEV8"/>
    <dbReference type="STRING" id="1450535.A0A317XEV8"/>
    <dbReference type="GeneID" id="37109057"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000710">
        <property type="entry name" value="Serine 3-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42901:SF1">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY96227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="266" mass="28815" checksum="A53B949EF111C804" modified="2018-10-10" version="1">MSLKGSNVLITGASMGIGEAIANALAREGANLILFSRSEDKLQTITNTLQKQYPAAKVIYKAVDIQSYEAVEQAVSDSVELLGHIDILVNNAGLALGAPATFSDLKVSDIVTMNSTNINGLMFTTYAVLNASMKPRKAGTILNITSVTGLEVPPFPGEAVYHCNKAAQEAFSNALRNELSETNIRVLVLRPGCVATNFHSLRVGHNKEKYDSFFEGYQPLVSEDIAHSAVFMLQQPVNVSIKALDVVPSAQRSLNVFDRTWNERNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFD4</accession>
    <name>A0A317XFD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative serine-threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_508733</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472201.1">
        <property type="nucleotide sequence ID" value="XM_025609676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFD4"/>
    <dbReference type="STRING" id="1450535.A0A317XFD4"/>
    <dbReference type="GeneID" id="37111819"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="365" mass="41918" checksum="13FA0F1A4CCFE926" modified="2018-10-10" version="1">MLHEEQNGADPVCVGQIMHDRYELIKNLGSGCYSTVWLVRDQSIESSYKAIKILSPECYDGKHDLFELEIMKHLSKANPSHPGYQHIPIILDDFVYESHQGHHVCLVMELMADNMKGFAFFFEGVKIPNNIMKKITKQLLLALEYAHDSGVIHTDIKQDNIMVKIRDPLMVDRYLKDSQSIKNISLGEYNFDHPSEFPEISIALCDWGFASWEERHLTPLIQPLLLRAPEVIIQAPWGKEVDIWNLGALLPELLDAVRMFNGRADVTGGTYYTKHHIEEIDALFGPFPLEMLKAGDQDIVQKLFDENSQIRDPIERPPAKLERWIECLDGVEKENFLSMLRAMLTIDPIRRPTARALQDALWLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGQ2</accession>
    <name>A0A317XGQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_480755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472901.1">
        <property type="nucleotide sequence ID" value="XM_025608837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGQ2"/>
    <dbReference type="STRING" id="1450535.A0A317XGQ2"/>
    <dbReference type="GeneID" id="37110980"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051604">
        <property type="entry name" value="Ergot_Alk_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43162:SF1">
        <property type="entry name" value="PRESTALK A DIFFERENTIATION PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="305" mass="33203" checksum="82B055B64712320D" modified="2018-10-10" version="1">MLVAVLPASPKTAQETIRVLLEADQLTSPVGVHAIYRDLSKAPREFCAHAGFHAVAGDLNDATSLDLGGADTVFAITPPRYDGSDMMQWATIASENTRLAIQKAGSVKRLVLLSSMGAEQPSGTGEILTNHIAEEILKDVVPEIIFMRCAYFMENWAPAVLTVKSDQPHFDSPITPLDYEIPMVAVTDIGKACATYLMAIHIPKHPYVIEVQGPQDHTVKDVQKAFEEAAGHAVEVRPVEKARLATFFGQFLPDASVGPFVEMTISFLPGGILARKADNNSSKDVRLYRGRTDLGEAIGRMYRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGW6</accession>
    <name>A0A317XGW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2,3-dihydroxybenzoic acid decarboxylase dhbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_529648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473021.1">
        <property type="nucleotide sequence ID" value="XM_025610492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGW6"/>
    <dbReference type="STRING" id="1450535.A0A317XGW6"/>
    <dbReference type="GeneID" id="37112635"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000043">
        <property type="entry name" value="Amidohydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="65"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="338" mass="38793" checksum="756197F43EFAFC6D" modified="2018-10-10" version="1">MLGKIALEEAFALPRFEEKTRWWASLFSTDPETHVKEITDINKLRIEYANKHSVGYQILSYTAPGVQDIWDPVEAQALAVEINNYIAEQIHDKPDRFGAFATLSMHNPQEAATELRRCVQTLGFKGALVNDTQRAGPDGDDMIFYDNTDWDIFWQTCAELDVPFYLHPRNPTGTIYDKLWADRKWLVGPPLSFAHGVSLHVLGMVTNGVFDRHPNLQIILGHLGEHIPFDMWRINHWFEDRKKLLGLAETCKKTIREYFAQNIWITTSGHFSTTTLNFCMAEVGADRILFSIDYPFETFEDACVWFDGAELNLVDKVKIGRDNAKRLFKLGEFKDSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVT1</accession>
    <name>A0A317UVT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_479686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461599.1">
        <property type="nucleotide sequence ID" value="XM_025608756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVT1"/>
    <dbReference type="GeneID" id="37110899"/>
    <dbReference type="OrthoDB" id="4506793at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="73" mass="8115" checksum="556140862A8A4B57" modified="2018-10-10" version="1" fragment="single">AVYGTGVLPSVSGFVQAPAVPRRITRSYRMTTTDPRSRSFRPGSQPYHPYPTVESKSDTFPNARKTVAPRAQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWT1</accession>
    <name>A0A317UWT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_430706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461600.1">
        <property type="nucleotide sequence ID" value="XM_025607476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UWT1"/>
    <dbReference type="GeneID" id="37109619"/>
    <dbReference type="OrthoDB" id="5302289at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY66145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="83" mass="9677" checksum="098EF7CF55E14D99" modified="2018-10-10" version="1" fragment="single">RTALDRARDNQGDSGTAAILEAAVGKLWERIKNEPEYVLNREEFALFNYFIYRYGKQPEGRRAVEQFWNHYRPNHSASNGSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXD9</accession>
    <name>A0A317UXD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glutamate carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_479854</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000055">
        <property type="protein sequence ID" value="PWY65951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461530.1">
        <property type="nucleotide sequence ID" value="XM_025608767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXD9"/>
    <dbReference type="STRING" id="1450535.A0A317UXD9"/>
    <dbReference type="GeneID" id="37110910"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05676">
        <property type="entry name" value="M20_dipept_like_CNDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017153">
        <property type="entry name" value="CNDP/DUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF4">
        <property type="entry name" value="CARNOSINE DIPEPTIDASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037242">
        <property type="entry name" value="CNDP_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="10">
        <location>
            <begin position="220"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="7">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between homodimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="9">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037242-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY65951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="477" mass="52837" checksum="565D73384A91F9EB" modified="2018-10-10" version="1">MAPQLEPFFKQVDDLSGSFIDRLRKAVAIPSISAQDENRKDVFKMAHFLASELESLGAEVEQRPLGKQPGKEHLDLPPVVIARYGNDKNKRTILVYGHYDVQPALKEDGWATEPFQLTVDSQGRMYGRGSTDDKGPVLGWLNVIEAHKKAGVEFPVNLLCCFEGMEEYGSEGLEEFIQSESKKFFKDADAVCISDNYWLGTEKPCLTYGLRGCNYYSVSVSGPAQDLHSGVFGGSAHEPMTDLVNVLSKLVDPRGNILIPGIMDLVEPLTEEEKSLYGGISYTMDNLHESLGSETGIHATKERTLMARWRYPSLSIHGIEGAYSAPGAKTVIPAKVIGKFSIRTVPNMESEDVNKLVFDYIKGEFAKLNSKNKLDVWLQHDGKWWVASPKHWNFAAASKAVKQVFGVEPDMTREGGSIPVTLSFEQATGKNVLLLPMGSSTDAAHSINEKLDKRNYIEGIKLLGAYLHYVAEEPMDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYE9</accession>
    <name>A0A317UYE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipopolysaccharide biosynthesis protein rffA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_612245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461806.1">
        <property type="nucleotide sequence ID" value="XM_025616660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYE9"/>
    <dbReference type="STRING" id="1450535.A0A317UYE9"/>
    <dbReference type="GeneID" id="37118803"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019180">
        <property type="term" value="F:dTDP-4-amino-4,6-dideoxygalactose transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012749">
        <property type="entry name" value="WecE-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02379">
        <property type="entry name" value="ECA_wecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008687">
        <property type="entry name" value="PRK11706.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244:SF34">
        <property type="entry name" value="DTDP-4-AMINO-4,6-DIDEOXYGALACTOSE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY67084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="385" mass="42196" checksum="3628E6487856AFA1" modified="2018-10-10" version="1">MSDTAIPTTIPTITEKEIAAIQDAILTRTLTGKGKYTALCQRWLESSMTGGKAFVLSSCTSALEIAALLADLQPGDEVIVPSYTYVSTVNAFVVHGAVPVFVDLDDATMNIDAQLIEAAITPRTKAIVPVHYAGIACDMDTIMAIADKHDLLVVEDAAMACGGTYKGRALGAIGHLGCISFQEKKVFTSGGQGGALLINQESLIPRAETIYEHGTNRGQFLRGEVNVYHWLDVGINATLSEIQAAFLYPQLQAAPEILAHRRHLWTRYHQRLRPLDQAGVIKLPRPSKEAVHNAAVFWLRLTDASRRPEFIRHMAAGQVCTQAQFVPLHSSPFGQQIGRFHGEDRVTTRAASEIVLLPLYSELDEERQEVVVRRVLKFWDGGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZR0</accession>
    <name>A0A317UZR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Calcium/calmodulin dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_613805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461642.1">
        <property type="nucleotide sequence ID" value="XM_025616717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZR0"/>
    <dbReference type="STRING" id="1450535.A0A317UZR0"/>
    <dbReference type="GeneID" id="37118860"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="341" mass="38983" checksum="A1D2723CB3A3A486" modified="2018-10-10" version="1">MPPLGSIFSPARYSFKNQAYSNLVVPNLSGRKFILPPSTLHRRARTMSTSAVNTEGHVGQSGSQYKIERVFQEETDPPRQVYLATAGDRKFILKYIHTVNFEYLQDINNRLHNRASHVLNVLFEYLADHLLHLSQKDLPLGIIKRILKDGLHGIAEMHDQDIVHTDIKADNFFVNWKASHNGITIERVQLGDLEDAAHIPPGSHMIGKQAGNWMWRSPEAHAKGPVGKPFDIFSYALVCICVLYKHVILAVGEDELDEGIHRLAIVIERQISYFADEEGFNRFLNYLGDNPWVPIFKVTWDGFNRENPRKPLSLWKGIDDEFKSLICAMTDFDPRQRITAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V1I3</accession>
    <name>A0A317V1I3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lon protease homolog, mitochondrial</fullName>
            <ecNumber evidence="11">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">PIM1</name>
        <name evidence="17" type="ORF">BO94DRAFT_479815</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer or homoheptamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the peptidase S16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V1I3"/>
    <dbReference type="STRING" id="1450535.A0A317V1I3"/>
    <dbReference type="OrthoDB" id="2411602at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070407">
        <property type="term" value="P:oxidation-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19500">
        <property type="entry name" value="RecA-like_Lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000021">
        <property type="entry name" value="Lon protease homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000113">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5270:FF:000001">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1480:FF:000003">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.40:FF:000006">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000015">
        <property type="entry name" value="Lon protease homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03120">
        <property type="entry name" value="lonm_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054594">
        <property type="entry name" value="Lon_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027503">
        <property type="entry name" value="Lonm_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718">
        <property type="entry name" value="LON PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43718:SF2">
        <property type="entry name" value="LON PROTEASE HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22667">
        <property type="entry name" value="Lon_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="16">
        <location>
            <begin position="205"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="15">
        <location>
            <begin position="900"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="42"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="831"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="65"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="992"/>
        </location>
    </feature>
    <feature type="active site" evidence="11 12">
        <location>
            <position position="1035"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="610"/>
            <end position="617"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY66050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1116" mass="122668" checksum="56A4F80E27CBA32D" modified="2018-10-10" version="1">MLRGQTLPWRAALHQTSRPFIPRPLLAPSKYNVTARSILNSSRLRRPLPSSTRTFSSSSIRRREKPPPGDEKDDPAQKEQRDANEDKDVERAPDARRKAADSSSKHGSSHEPGAPTSGFARRKEKAGGDKEQRGLEEDSKKDGHAVEGKGSSSDTPSPIPVSGGSDSRPSGANNGGNEDGGKKGKKGSGEKALQKPSVPEVYPQVMAIPIAKRPLFPGFYKAITIRDPNVAAAIQDMMKRGQPYVGAFLFKDENADGDVIENLDDVYDVGVFAQITAAYPLRGEASGVTAVLYPHRRIKVSSLLPPSDPAKAGATDDKAAERRGDVVASFEEGTAELAPKDHYEPTSFLRKYPVSLVNVENLTEEPYDKKSAIIRAVTSEIVNVCKEIASLNPLFRDQISAFYTDQFPGNLSDEPAKLADFAAAVSAGELNEMQEVLELMNIEERLPKALVVLKKELMNAQLQSKISKDVEAKIQKRQREYWLMEQMKGIKRELGIESDGKDKLVEKFKEKSEKLAMPDAVKKVFDEELNKLAHLEPAASEFNVTRNYLDWLTQIPWGQKSVENFGIQHAVKVLDEDHYGLKDVKDRILEFIAVGKLRGTVEGKILCLVGPPGVGKTSIGKSIARALNRQYYRFSVGGLTDVAEIKGHRRTYVGALPGRIIQALKKCQTENPLILIDEIDKIGRGHQGDPSSALLELLDPEQNSSFLDHYMDVPVDLSKVLFVCTANVTDTIPRPLLDRMELIELSGYVADEKMAIAQRYLAPAARELTGLKEVDVTLTEEAVEELIKSYCRESGVRNLKKQIEKVYRKAAYKIVRDLGEDVLAEEKALTVEGKAAQEESQKETESTGSVNSPVDPEKSTTETPRVALTVPDSVQLSIGKDSLTDYVGPPIFTADRLYDTFPPGVTMGLAWTSMGGAALYVESILENALSPKSRPGIDITGNLQTVMKESSHIAYSFAKSVMAKQFPENRFFEKAKLHMHCPEGAVPKDGPSAGITMATSLLSLALNHPLDPTIAMTGELTVTGKVLRIGGLREKTVAARRAGAKKIIFPADNMSDWLELPENIKKGIEGHAVGWYSEVFDILFADLDKGDANHVWQKQLADKPSKKSNEVEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V217</accession>
    <name>A0A317V217_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_478481</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462147.1">
        <property type="nucleotide sequence ID" value="XM_025608690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V217"/>
    <dbReference type="STRING" id="1450535.A0A317V217"/>
    <dbReference type="GeneID" id="37110833"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY68125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="547" mass="62329" checksum="C6450BEDFA634425" modified="2018-10-10" version="1">MDLQSPSTSLTVFCIGVALHVFVFRIGEWDLATTKLLRVFATTSVAFVILVKVILLSPPDNTLWTALTIVSWLVTSLITGIGISMLVYRVLFHRLGRFPGPFGARLSSLYGTLLSAKNLHLYEEVEKLHNTYGDFVRLGPSELSINNPKAVHAISSSQSPCTKGPFYTVLDPRKSMHMIRDPAEHARRRKVWDHAFSAKSLRDYEPRVSLYTDQLLAHLEKTKGQPVNVSDWFNFYSFDVMGDLAFGKSFNMLQNGVKHYFMASLHADMTTVGVLSRLPWLFPIFKATPGLNYEHLRFWKWVDDQIDERKKTTADKPDVFKWLLKDYNAQEKPTFNDEMYLAGDAYLVAVAGSDTTAAGLTTIFFQLALDHRVLKTLQNEIDRYFETAGTVDYTSLSKLPYLDAVITETMRLHPPIPSGVQRMTPPDRLLIDNTWIPGNTIVQVPYHTLFRDERLFLQPQDFIPERWTTRPELVRDSSSFVPFSNGRYACIGKHLGLMELRLVVSQIVRRYDVEFAPGQTAEAFLKGKRDAFTLSLGKLEMVMNPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V403</accession>
    <name>A0A317V403_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_540143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462318.1">
        <property type="nucleotide sequence ID" value="XM_025612847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V403"/>
    <dbReference type="STRING" id="1450535.A0A317V403"/>
    <dbReference type="GeneID" id="37114990"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF23">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN TPCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY69003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="114" mass="12635" checksum="8CFBA15D2B53A18E" modified="2018-10-10" version="1">MTTTILPLTLYGKGGPNPPRVATILTELSIPYTTFAIPLSTVKQPSYTAIDPNGRLPAFHDPNTNLTIWESGVIIQYLISRYDKTHKISFPEGTSKSYLTAQWIFFQASGQGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4C6</accession>
    <name>A0A317V4C6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-acetolactate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_570032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2</text>
            <dbReference type="Rhea" id="RHEA:21580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15686"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="4.1.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; (R,R)-butane-2,3-diol biosynthesis; (R,R)-butane-2,3-diol from pyruvate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-acetolactate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.5" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462001.1">
        <property type="nucleotide sequence ID" value="XM_025614771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4C6"/>
    <dbReference type="STRING" id="1450535.A0A317V4C6"/>
    <dbReference type="GeneID" id="37116914"/>
    <dbReference type="OrthoDB" id="509395at2759"/>
    <dbReference type="UniPathway" id="UPA00626">
        <property type="reaction ID" value="UER00678"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047605">
        <property type="term" value="F:acetolactate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045151">
        <property type="term" value="P:acetoin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17299">
        <property type="entry name" value="acetolactate_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005128">
        <property type="entry name" value="Acetolactate_a_deCO2ase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35524:SF1">
        <property type="entry name" value="ALPHA-ACETOLACTATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03306">
        <property type="entry name" value="AAL_decarboxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001332">
        <property type="entry name" value="Acetolac_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0005">Acetoin biosynthesis</keyword>
    <keyword evidence="6" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY67652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="241" mass="26008" checksum="377544BB353EB00D" modified="2018-10-10" version="1">MPPNQLYQYSVIGALLHGICADGLPAHRLLDHGSYGLGTVADLDGEVIILDRKAYHFPSTPGSLIRALNPDDRIPFALMTDFHPTHTIPITTPLTVTTLLDNIAPLLGRSQNHFLSIRLQGSFPTMTTRIIPKRASSETLGDLAQRQSVATIVESTGTLFGFWSPPYTAGGIGVPGIHLHYLSEDRHSGGHVLDFRAEGGQLEAAVVRKLEIELPDTEEFGAVAMDGVEAEAVGRAEGLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4C7</accession>
    <name>A0A317V4C7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_300728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462162.1">
        <property type="nucleotide sequence ID" value="XM_025606746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4C7"/>
    <dbReference type="GeneID" id="37108889"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="622"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY68499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="738" mass="82813" checksum="BFE5219B7BC08AB8" modified="2018-10-10" version="1">MSESQSTTRNLRRAKACNTCRRKKVKCDGKRPACSPCHAFNLPCAYQDVAERRNRGSRAYIEELEQRIERMQAQLESLSKPGNEQRNAETPRESTSPSVEDRELEHPAQGIHPSETGQMLSEDGIHPTSDCHEKDQSFIINAQDGRTRYFGASSAFSALSDATVSGPENQTEMAARRRAPQRNSSAWPLTSWVPSILQDGPERRSFEPLPHKHVTMQVLGEYFATFNQAIPLFDEASFMRAVNRQYSWNPDDSASWWISLNIVLAMSYRERTHASPDGSDNWKRSLGHVKNALNAVTDVFLRNTDLSAVQGLLGLALYFQGTPNPQALFMFAAAAMRLAQSIGLHRSPAHGTSFEDEQRRRTFWIAFFLDSDISIRVGRPPIQDIEDYDTSLPMEDPPDGKGILSIDGIRINFFRLLVQLALAQRHVYRHLYTVTIRRQTSEKVIEEVKSCAKLLLRWKNSVPPRLQPQREFVCQPSYFLQHIVRLHFAYHCCYSNLYQVCMFQANATQRPSNGRDEDISLIVSRSLDSARSALALLSHINLLGSTYKWNVIYFPAAASVPLALRLLTNPTHSFAGVDFAMIRDIVNFLANTASEEPGTYVDYILGMCSDLERSARQAIMTAQQGPRPMVGANKENSAPDGIREGTSRPAGYPIYNTLSTSSSSAPMLDEGSAHTMNILPQAPYPDIEFPTLAAEYDVTPNWQWSLPPFWNWQDIVPGVPSFPVVPGGDTPEVNVPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4W8</accession>
    <name>A0A317V4W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1593-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_479023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461884.1">
        <property type="nucleotide sequence ID" value="XM_025608728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4W8"/>
    <dbReference type="STRING" id="1450535.A0A317V4W8"/>
    <dbReference type="GeneID" id="37110871"/>
    <dbReference type="OrthoDB" id="3592035at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048527">
        <property type="entry name" value="Sde182_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011483">
        <property type="entry name" value="Sde182_NH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21027">
        <property type="entry name" value="Sde0182_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07632">
        <property type="entry name" value="Sde182_NH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016390435" evidence="1">
        <location>
            <begin position="18"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 nucleoside hydrolase-like" evidence="2">
        <location>
            <begin position="35"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose-binding Sde182 C-terminal" evidence="3">
        <location>
            <begin position="395"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY67240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="494" mass="54508" checksum="85EA25B31F04CADC" modified="2018-10-10" version="1">MKAFLCLPLFSAGLTLALPHSKANRSLLSYPTKPRVFILSDIANEPDDSESLVRYLVYSNQFQNEGIVATTSTWLRDEVRPGLMLDTIEAYAKVVDNLNNHAPKDAPFPSADYLRGIVSHGLPVYGMKALLNNNTYSPGTELLINSITNTSSDQPLWVLGWAGTNVLAQALLNISLTHSASAAAALRANLRVYAISDQDDTGPWIRHNWPDIHYVSSVHGFDQYAGATWPGISGETGYDFDKGGPDTSLVSHEWLKKNIRIGTLGAKYPDFEYIMEGDSPTLLYVIQNGLGDREHPRYGSWGGRYSAVCDNCDWDNHYSDAEDQVIGLNNQTFKSNKATIWRWREAYQNDFAARMQWTLSASETNETWNHNPVVIVNGTGGLDPVPVNVSVGERVAFDAGETYDPDGDSLSFHWFQYLEPSTDNASAKGNVGELNITSTSEGRMVSVAIPSTENTCDEDGCQLLHLILQVKDTGSPPLTTYRRMLIQVSNTTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V659</accession>
    <name>A0A317V659_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_540207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462191.1">
        <property type="nucleotide sequence ID" value="XM_025612863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V659"/>
    <dbReference type="GeneID" id="37115006"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF2">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY68528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="171" mass="19534" checksum="71F5C2DA67371E69" modified="2018-10-10" version="1">MMSTLVPTIIGLNEATKGARDQEDNRRNEARSQRCHLIATCEVSAGSQAQRRQVQNAKVYLDQDYKVCCGEYSCCEMEVDVKYGQYYEHPAFGEDNSSGLITMSPENPPLARWVYLDSETNELRYGGRKESESNVCGPFDWSEDEQYVTLEGNERWLAVRLAEDARKEQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VB99</accession>
    <name>A0A317VB99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphotransferase</fullName>
            <ecNumber evidence="12">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_540082</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462405.1">
        <property type="nucleotide sequence ID" value="XM_025612833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VB99"/>
    <dbReference type="STRING" id="1450535.A0A317VB99"/>
    <dbReference type="GeneID" id="37114976"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046323">
        <property type="term" value="P:D-glucose import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990539">
        <property type="term" value="P:fructose import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1250:FF:000001">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000092">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000004">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="13">
        <location>
            <begin position="27"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="14">
        <location>
            <begin position="227"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY69200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="490" mass="54132" checksum="47F3BAC916EC6E2E" modified="2018-10-10" version="1">MVGLGPKRPHSRKGSMADVPQNLLQQIKDFEEHFTVDRSTLKKIVDHFIKELEKGLSVEGGNIPMNVTWVLGFPDGDEQGTFLALDMGGTNLRVCEITLTQEKGAFDITQSKYRMPEELKTGTAEELWEYIADCLQQFIESHHENEKVSKLPLGFTFSYPATQDYIDHGVLQRWTKGFDIDGVEGQDVVPPLETILQKRGLPIKVAALINDTTGTLIASSYTDSDMKIGCIFGTGVNAAYMENVGSVPKLAHMNLPPDMPVAINCEYGAFDNEHIVLPLTKYDHIIDRDSPRPGQQAFEKMTAGLYLGEIFRLALVDLVENRPGLIFNGQDTTKLRKPYILDASFLAAIEEDPYENLEETEELLERELNIKATPAELEMIRRLAELIGTRAARLSACGVAAICKKKGIESCHVGADGSVFTKYPHFKARGARALREILDWAPEEKDKVTILAAEDGSGVGAALIAALTLKRVKAGNLAGIRNMAEMKTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCX9</accession>
    <name>A0A317VCX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="16">PE methyltransferase</shortName>
            <shortName evidence="16 17">PEAMT</shortName>
            <shortName evidence="16">PEMT</shortName>
            <ecNumber evidence="16 17">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_539349</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16 17">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16 17">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16 17">Endoplasmic reticulum membrane</location>
            <topology evidence="16 17">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16 17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="16 17"/>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463177.1">
        <property type="nucleotide sequence ID" value="XM_025612688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCX9"/>
    <dbReference type="STRING" id="1450535.A0A317VCX9"/>
    <dbReference type="GeneID" id="37114831"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2840:FF:000006">
        <property type="entry name" value="Phosphatidylethanolamine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 16 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 16 17" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13 16 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14 16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16 17" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="410"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="517"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16 17">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="344"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="717"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY72224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="985" mass="111493" checksum="21A8466BBC1284FB" modified="2018-10-10" version="1">MTGFARGFQPFSPSHPSALGHSLLLARSKPRTVQTKTRKPLAGPLTVQVGIVPDYTSSPVDSCMSMPSVDNGVPYLPSGGIIRLTCMIVSVFTVPQTHDMVSQLLSPSEPKNLSDLIVLAILGAHILLLWWLPVGAKIPVFAAIYLFWRAAYNAGIGWLLHNQSHHKTLVRWAEKTRIFVNPSTNENPHPHLYKLLKRELETKIPTDYSFEEAPIEYNTWLVFRRLVDLILMCDFTSYCLFAIACSHHPLGESMLMTILRWSAGIVLVLFNLWVKLDAHRVVKDYAWYWGDFFYLIDQELTFDGVFEMAPTPSSYKVLFISIIAHAAQFAFLVLVENPHIDKTYNPPPPRKRMTEQESVSASSQTTEPSNAPASVDDQLPQATMYPSNPPPSVHDLLGFNNLDLYRTTDTSSVLVQFLVFALTVLTPSTPRYQFLFVANATIWRLWFSIGIGYLLNEQSNCKAWTRHFLKYGETPSEAWNQWKGTYHLSMIMCYASFIAAVWKMYTFPADWGYGLVLLRHVLGAGLISLQIWTSASIYESLGEFGWFYGDFFFDGAHKLTYNGIYRFLNNPERVLGLAGVWGAVLITSSGAVTYLALLSHILSLAFIQFVERPHMQKLYGRSLRQDAGLVKSLKRTLPPTLRQLHGSVDKIFDDSFEFIEDLIDTARPRLASGVNTFVKDTTALFQKYPARVTISRIDEDLAGFDSRDYTLEIEGTDSSSSLDECDKSSGREGANARVPLDRRGDLKNLVFEYGSPIKVKWTAPLNHSKKDWISLYRVTDNTSREVSRVSSQARWVAVNEGIYDNLTCEKGIMSSDVVAKNEENRDVATGEVIFSGDKLFWTQGVFEFRYHHNGKHNVMAISRPFEIRIRRFDEESFEDNQMSVEKSLLPVVRNCFDCDPEIAPETVEEQFGSLVERDGKFAKRVVFAVHQMFGIEFAPEVVRADGTVRNLAWRICNAKRVLAPYSMTRDGATTPTERNEEKVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VEA8</accession>
    <name>A0A317VEA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Camp independent regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_261085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462999.1">
        <property type="nucleotide sequence ID" value="XM_025606494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VEA8"/>
    <dbReference type="GeneID" id="37108637"/>
    <dbReference type="OrthoDB" id="5319641at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY71601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="471" mass="51267" checksum="8B7549DD2423FA84" modified="2018-10-10" version="1">MVNGTATVLEPTFTGYVATTQDALILFEACLTGVLHHVPRRPHDRERGHLVRSGSVFIYEENSSGIKRWTDGVTWSPSRILGNFLVYRELEKPFPPGEKKRAMKKANRRPVPSTRPGEPYPRQESNGGYSPSSTTGPYGDRPHQSDVERALVGSLVDSYGFKDSGLVKKTMSVTVSGVTHHLVSYYSVEDVMRGLLNPPSMVDTLRYIRPRVELTQKQSFRAPIDDLETGGLENPNDPHTLYGYRPQLVAPPGYAIPNPHPEFYLHTTPYTTHPPQSAPIPGYSMAGSISAQPASNPYLPAPSAPTQIPQKPDDYSQFRAPTQYGTSFDLGHNPLSSSIPSALNTGIPSSLSDRNRSQSDHSPSAYRNSSISSRSVATDATSPIDPATPATYSRGGSFSLGPLDGPHQPLEQRGLGSFDSGIPRRESNAIPAPYYTGADRHQYYVGATAPAAHTNYPVSTWTTAAPAQPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VEK0</accession>
    <name>A0A317VEK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_501594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462895.1">
        <property type="nucleotide sequence ID" value="XM_025609436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VEK0"/>
    <dbReference type="STRING" id="1450535.A0A317VEK0"/>
    <dbReference type="GeneID" id="37111579"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="139"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY71497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="359" mass="40263" checksum="E240B6BB96C3DAB4" modified="2018-10-10" version="1">MPRIPNRTILNAYRQGHLLPLLLQECRTLGSAKNELRWLKDRAIHKAQLNLARRAVTSKHCFQGWRSLLRSMCRARSRGLPLQYILGDQPFGDLDIRCKRGVLIPRPETETFTFHAANLILNDMINERHFPVENRATSLRILDLCTGTGCISLLLHALVAPHVQKISIIGIDISATAIDLARNNLMHNVRRGYLSDRALTDITFKQGDVLDAVGDVFGSSSHTGPPPDVIISNPPYISEESFGNGATTRSVRMFEPRIALVPSKDHHDMSELPLKGQEDIFYYHILSRSFRLKTSLVILECGDHSQGGRVAALCNDLAAEYFQVGNLRINIWPAVDKGIADHGSEEYTEPCVVIVQRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VH41</accession>
    <name>A0A317VH41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasmic dynein intermediate chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_560050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463261.1">
        <property type="nucleotide sequence ID" value="XM_025614121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VH41"/>
    <dbReference type="STRING" id="1450535.A0A317VH41"/>
    <dbReference type="GeneID" id="37116264"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000425">
        <property type="entry name" value="Cytoplasmic dynein 1 intermediate chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="497"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY72487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="679" mass="74683" checksum="377A1229F40AA6DC" modified="2018-10-10" version="1">MSSAMQQRKAEILAKRAKLAELKRQRELRQKEFSQARANTGDASEVVSPVPSRADSRAELDDLISRLVDRPGSASISHGADGLSRKGSRPNSVLSASQLSGDNTEAFIPPTRPVSQSIAVQTVGTEPFVAAPEPQPAPEPKPEVVTYSKGVQTDDLKPSDSAESENEENNANKKDTERDEEILKKLRQEIEEELRATQQRADHDAGAESSNLRYPLRTLDDDELKAVTSSDDFLDFVERSAKVIERALDEEYDVLADYELGGVDGELEDDDEHGRKRRGIREVCQFWDERWSKKRMISDLSFSPKFPELVLAAYTKNPSAPHEPDGLVQIWNQHLHSRPEYVFHSTSDILAAKFSPFHPNLIVGGSYSGQVLLWDTRSSRAGGGAPVQKTPLTGSGHTHPVYSISIIGTQNAHNILTASTDGVVCGWTVDMLSQPQEYLELSTPPPSKTEDLAPTTMSFPQSDPTFFIVGTEEGGIYPCHRYDRAGAKAGTDHRLVYRGHKAPIMSTAFHPARGPVDLGDLMLSSSLDWSVRLWRIRPPATTAPATSAIATTQVVEPILDINREDVVYDARWSPHRPGVFSLVDGAGNLEVWDLYTDTEVPVVKTTPSKGRGGILTRSLNKVAWEEREGRRIATGGLDGVVTVFEVGKGLSGTPEDVPAEEWSGMKKLVGKLEQQDRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLL3</accession>
    <name>A0A317VLL3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_538876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463580.1">
        <property type="nucleotide sequence ID" value="XM_025612577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLL3"/>
    <dbReference type="STRING" id="1450535.A0A317VLL3"/>
    <dbReference type="GeneID" id="37114720"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="375"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="3">
        <location>
            <begin position="655"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY73828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="888" mass="99061" checksum="ADBB971C1BE43292" modified="2018-10-10" version="1">MATLEKSPFANDEYTVGWVCALPIEFAAARGMIDEEHGQPQSAPAESDKNSYFLGSMGKFKTVVACLPLHQLGSPHAVAAAKEMLFTFPKIRVGLLVGTGAGIPDIDNDLDIRLGDVVIGSSPGSGGVIVYDFGKIRDGEFESLSVLNRPPKALGTALGKLQALHESRENMVAHYVEEMLVKHPLMRKNYTHPGQSSDRLFQANYRHVSGSKNCNKCEASQHVEREPRLDENPVIHYGTIASGNKVVKDAAVRDEIRDRHGAMCLDMEAAGLMNNFPCVVIRGIANYGDSHKNDRWQRFAAAAAAGCAKELMQHIQMNSLDGEPAAKDLLSQVHDEIAKISSFAITGQTRQVLEWLTPLDFDKCQNDYMRVTEEGTGLWLLKSPEFTQWMSRPNQTLFCPGIPGAGKTCISAIVVEHLRKNTQENPEIQACYIFCSYQPSHQQRNADIMLNLLRQLAVKGSSLLANIENIHKRHSQDRTIPTAAEIESEILRTAKSYEMIYIAIDALDEYCTSAPDELHNLLTQLFNLQENAPVNIFATSRFNTEIMARFEGCLTKEIQAHPDDIEKYINRKLPGFLSKISSDPEIQQSVRHEVVKRADGMFLLAKLDIEHLIHCPSRGALKKALFSPSYDQKSLEMAYQKAITRITSQKEECFQIARSTLAWLTYSRRALFAKELQHALGTELGKTELDPDFLPPLDIIDSLCAGLVVFDRNSGIIRLAHYTTKEFLIGNHLLQNAETEITQVAITYLSFSSGRSSDSGEYTHQQQEYPLHHYVAQHWMSHASAALAESNQSEKLINFILQFLNKESNAFAAGQAMISQSYPILGDEKNHPVAYGGLTEMTSRYIDSNEDIIKTEDSECKTPPPYAAQRGHLDVVEYILKSGNVRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VMR0</accession>
    <name>A0A317VMR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gluconate 5-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_499602</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463832.1">
        <property type="nucleotide sequence ID" value="XM_025609385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VMR0"/>
    <dbReference type="STRING" id="1450535.A0A317VMR0"/>
    <dbReference type="GeneID" id="37111528"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY75205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="258" mass="26319" checksum="94626A75E92297DC" modified="2018-10-10" version="1" fragment="single">MSQPDSLSLQGKVALVTGSGKTRGIGAAIAALLAHHGASVVINYVSSSTAPSAAGVAEKITSAGGKALVVQADISRPEEAQRLVHETVTTFGKIDILVNNAATGVPGPVLSATPEAITTTFAVNVFGPIYLTQAAVSHMPPHSRVINIGSVASKLGVSGSPLYSASKATMDALTFSLAMELGRNHGGITVNTVSPGPVDTDGLPPHVAEKINEKMVPLSRVEERLGTVEDVADAVLLLCSEKSRWISGQVISVSGGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VP02</accession>
    <name>A0A317VP02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_605342</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464063.1">
        <property type="nucleotide sequence ID" value="XM_025616485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VP02"/>
    <dbReference type="STRING" id="1450535.A0A317VP02"/>
    <dbReference type="GeneID" id="37118628"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF4">
        <property type="entry name" value="BLR3857 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY76066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="624" mass="70198" checksum="712A9BDADCCC3EDF" modified="2018-10-10" version="1">MGSFFSVLSFFQRPRDPLQAEAQALQTDTLSSKYEEERAKRLRADGVAQFHETEGIYRPFQTDIGAPSLTRDRIDSETTVLIVGGGYGGLVTAVNLCKQGVEDFLIIEKGADFGGTWYWNQYPGVTCDVESLLYLPFLEETGYIPKDRFSYGPEIRAHVARIVERWNLASRAHLQTEIRTIRWDEQLGQWHTETNHGDHLKSRFVVLATGTLHKPKLPGLKGIEDFQQDHFHSGRWNYHITGGDATGKMIKLATKTVGIIGTGSSGVQLVPKLAQDAKKLYVFQRTPSSVSLRHTRPPDPDIIASLSPGWQRAQMDLFAGILQGEILDDVECSAVEGLDALTIREIHAEATRMGVDVKAHPEKIGEVYRLLDFRLMERLRKVVEETVQDKATAEKLKPWYAFMCKRPAFNNEYLSAFNLPNVELIDTNGQGVSHLTATGVVANGQEYPVDLLIYSTGFEFEVGSNFYRRTGIQLIGSKGQTLDEKWEGNPGGGPSTLFGIHIRDFPNLFNIGPAQAGVTANQLHNIYIAGEHIAEVVRTCLQTQAFRIIEPTEEAEEEWGKQIEVGRERRLEFAQTCPPGYYNKEGKPEEIPARWGVYPQGILSWEKVLKEWRQEGSMKGMERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPV8</accession>
    <name>A0A317VPV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rtt106-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_538275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTT106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464217.1">
        <property type="nucleotide sequence ID" value="XM_025612458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPV8"/>
    <dbReference type="STRING" id="1450535.A0A317VPV8"/>
    <dbReference type="GeneID" id="37114601"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="5">
        <location>
            <begin position="287"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="449"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY76404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="493" mass="54269" checksum="72065303926F19C6" modified="2018-10-10" version="1">MAFATINSSVPAKIPAIEDAFAAEPALKKRVYDAIGAYGSLRTTSYINLTTPYNSQNDQLTSIPQTAHTPQHVPLFEDIAKYTSSLLARTATGPVRPVEVVSDGPALKKRKLQNGDATNTQSSGDVKADTPLLFYMQDVSFAVPQRKKLTLEVTAGHGFLRARNQTSKEVEFGIQLDKIQHVLCLPVPEKNQRQFNFCIIPQYADGVNSPPEGVTAPEAIVWTVADGPPKAAFSGDGKQLGTNNDETTDKIVQRVLNDNLSQTKVVRPDERQFVSAMPEAHRKGEKAYHVKAFRGSKEGYLFLLSTGILFGFKKPLVFFAFENVDSISYTSVLQRTFNLNVVARPTSSDETQEFEFSMIDQADFAGIDEYIKKHGLQDASLAEARRAKRYNVNGAKAEDDAAAVNEERGAEGESELQKAQRELEDQEDEDEEDYDPGSDSDSDGSGSSSDDDDDQDEEGDMEEDDEEEEGEEDRDLVAQELGSEAEDVPAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRY9</accession>
    <name>A0A317VRY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Leucine rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_498437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464351.1">
        <property type="nucleotide sequence ID" value="XM_025609347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRY9"/>
    <dbReference type="STRING" id="1450535.A0A317VRY9"/>
    <dbReference type="GeneID" id="37111490"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000601">
        <property type="entry name" value="DNA repair protein Rad7, protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056451">
        <property type="entry name" value="Znf_Tbcl_Rhp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF234">
        <property type="entry name" value="RNI-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23550">
        <property type="entry name" value="zf_Tbcl_Rhp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair protein rhp7 treble clef" evidence="2">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY77164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="594" mass="66770" checksum="A8E8D89126E91104" modified="2018-10-10" version="1">MAERRQTRNQIRGPHSALTDFLASNNISAAQIHQNHQRRLRESERQSAVERRENAPDNDDEYEPVGESAEDRKKRKRKEAVALAKIKQSKEFARRKARRMGGPGDSDDEIAREMMHERSQPLPGQLENCEICGKRFTVTPYSKAGPQRGLLCAKCSKALADDEKKPKANRRGARSGRRQNQSNLLDGLAQQGALSLADMCTKKVADNINDIEEFGDLPSQLLHRLSQILCKRRVLTPRTLNLFLRPDLESIDIYDAARLETHDFEKIFTLMPNLSHVNIRFAGQLKNKVIEYMLDHSLKVKRLQLDAANLVSDAYWQQLFQKLGPQLEILKLSNLDFSLDDETIEVMCRYCTTLQRLKLKQCWKAGNRSLQAISGLISLEHLSLDYVQEVENEILLGTVSKISPRLQTLSLEGFTNVDDRLLGIIHDNCRALTKLRFSDNAVCTDRGFVNLFTGWANPPLEIVDLSSTRDIDNTNPDGPKDATGLASQGLLALMNHSGSKLQKLNIASCRHVSHSAFEEIFSAGTTYPNLKELDVSFHTVVDNYVVGRIFQCCPKLQKLVAFACFNLRDAQVPAGVALIGGLKAQDPIVLQGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTM3</accession>
    <name>A0A317VTM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464462.1">
        <property type="nucleotide sequence ID" value="XM_025612428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTM3"/>
    <dbReference type="STRING" id="1450535.A0A317VTM3"/>
    <dbReference type="GeneID" id="37114571"/>
    <dbReference type="OrthoDB" id="194076at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38052">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="5"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY77275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="98" mass="11875" checksum="14A3568468063CAB" modified="2018-10-10" version="1">MVYTIVVHMRAKPDEESISKLHAKLIEASRVYSQDKETLSWFVMQSVHDKQDFCIVERYLNEGSQKYHLENPYWKTFDPYVIPLLEKDMDLRRFEEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VU19</accession>
    <name>A0A317VU19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_523302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464171.1">
        <property type="nucleotide sequence ID" value="XM_025610211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VU19"/>
    <dbReference type="STRING" id="1450535.A0A317VU19"/>
    <dbReference type="GeneID" id="37112354"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY76358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="236" mass="26146" checksum="A0570960DD7CFE73" modified="2018-10-10" version="1">MASSPSSQPTLSVFPLLTAEEFETACHAFLDRVHVAGDTKVEWSSIRLDQRTTGPILSISREVGQVSTLHTSSDEPIPDSETNEVLQGEASEEDPEALIRAPEPSICLQVIYDVLLSPTYQVPVLYFQLRQDSHPGPLGIDVVYQYLVPDQYRKELESVGIMGGISFGYHPDCGTPTFFVHPCHTTDAMRHIAGKRCLTPEAYLIIWLGLVGNRLGLQLPKELFTTEGMEIFQGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VU41</accession>
    <name>A0A317VU41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_549255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464285.1">
        <property type="nucleotide sequence ID" value="XM_025613436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VU41"/>
    <dbReference type="GeneID" id="37115579"/>
    <dbReference type="OrthoDB" id="4509876at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="265" mass="29802" checksum="545619AAC43082D7" modified="2018-10-10" version="1">MEQASDMTNLFPDNEMSPVDKGKSPVGKGQTSRVSEPGPSCRHPHSSEAEATTSCNPSAPPKDDPSAPPEPPNEVQIDPHTPSHRFLYFFESETYVYFLIWIMQTIKEFRDSRVVIVGQVARQYHLDAGVIEMRFLGGAVGIKIHTFPVGGPLPPTVDDERIYRFALRRTSQTLGDLLPHSLPMLPLPLLILKAANDCRRTGPDDAELVWTLAQKLDRKHRWQDWQLYGLKDNLGKLVGADPGKAKKRTRDEWVEALRLEEQTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUT2</accession>
    <name>A0A317VUT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_472481</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464638.1">
        <property type="nucleotide sequence ID" value="XM_025608437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUT2"/>
    <dbReference type="STRING" id="1450535.A0A317VUT2"/>
    <dbReference type="GeneID" id="37110580"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF35">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY78126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="273" mass="30261" checksum="A45ECF2BB0580C65" modified="2018-10-10" version="1">MSGSDATGGWIAYQYNPSMPAAVIFAAFFMIGTFLHTFRMIQTRTWFLIPLVIGGYFEAVGYIGRAMSASQTPDWTLGPYIMQSTLLLVAPALFAASIYMELGRIISLVKAEKLAIIRVNWMTKIFVAGDVLRAGIMVNGSPTMGQNLIVGGLFVQIAFFGFFVVSALVFQIRIASRPTDEARNDLIPWRKHMFALYSSSVLILIRSVFRVVEYLEGSDGYLLQHEVFIYLFDGLLMLSVLVIFVVIHPSEVKRLLGRAGASTLKGVEMSMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVX3</accession>
    <name>A0A317VVX3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_568495</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464067.1">
        <property type="nucleotide sequence ID" value="XM_025614682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVX3"/>
    <dbReference type="STRING" id="1450535.A0A317VVX3"/>
    <dbReference type="GeneID" id="37116825"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="21"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY76070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="197" mass="20946" checksum="F9A477B345198EBA" modified="2018-10-10" version="1">MASSAESFTPVHTAPGWKQNVKDLVAGAAGGVAQVVIGSILSGPIEHIRIRLQTQPKPLYTGPLHCALTLLHQGGLPALYRGQTATLLREGHGIGVWFATYEGCLSLAAKQQSLTRETLPTWEIAVCGALAGEMLWLLSHPFDVVKSRMQSDGFGHDRRWGSFRGAVSGMLRDGGMWRGLGTALCRAGPVSGGTFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VY17</accession>
    <name>A0A317VY17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_180291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464838.1">
        <property type="nucleotide sequence ID" value="XM_025605973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VY17"/>
    <dbReference type="GeneID" id="37108116"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="112" mass="12531" checksum="ED7CA7E4B1C58D27" modified="2018-10-10" version="1">MPKIDWLEEARTQDLGGKNEQETKNSRHSNGTSNIQEGRGSGADGARMTALHAMDRVWENRSRLALEGRAEWRAAYFLRMAQERGNALGKSNATGKTVENMTNVGQEFSFFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYQ0</accession>
    <name>A0A317VYQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_472422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464560.1">
        <property type="nucleotide sequence ID" value="XM_025608430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYQ0"/>
    <dbReference type="STRING" id="1450535.A0A317VYQ0"/>
    <dbReference type="GeneID" id="37110573"/>
    <dbReference type="OrthoDB" id="5281682at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="574" mass="64941" checksum="3BD34C4AC18C767E" modified="2018-10-10" version="1">MISTIPPPRPVSVNSLARASASTAIPYSKPSRCTSAEIQIPDGPINPPAVGPGQLVCQSPVDTEMEDARISVETPRSCRSELHFEDLPIEIHEAILDYLFGERASAFTSCAPGKSVRSWNKSLRHPRRKALSNLALITPVWRALVQDRIYRHIKIKGTTDELAESARWFRAHPHLAPYVRHVELWIPVWGKRAVKNSSHLPPARRFNDEDADFDPVAPQATIAWDDSDTNHSTDYRYHYASHNATLEEMFSHVKSNFPEARILTLEGGHCKRPPMVRQFRQDPSGQTGRLRLPTLPDIQTFVMRGAWNIMREYRHWWNMSQALPGVREWHCAYAKPKIEGYQTVADILLRISPPLVHVNISLEGFYNKDNTQSGWIHDGISPPHLCRLLGEAAPRLESLAFTGKVCACLFHSTRAFMSTWTAKSKLKSLDLVVKTCCREKRTNPGLGFLDDFSGITNLNFIRSFEKLVLGAVHSLQVHSALSYMRIRFIDLDSACPPLNPYFQLVDNECTGLWSERILETLHEARPQAHYVELSDGIYPQYGHNRQIVGAVYPRTRPLSIHASTYKVIADVSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2J7</accession>
    <name>A0A317W2J7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NIPSNAP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_497381</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NipSnap family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465039.1">
        <property type="nucleotide sequence ID" value="XM_025609314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2J7"/>
    <dbReference type="STRING" id="1450535.A0A317W2J7"/>
    <dbReference type="GeneID" id="37111457"/>
    <dbReference type="OrthoDB" id="10262843at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000004">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000037">
        <property type="entry name" value="NIPSNAP family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012577">
        <property type="entry name" value="NIPSNAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051557">
        <property type="entry name" value="NipSnap_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017">
        <property type="entry name" value="NIPSNAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21017:SF17">
        <property type="entry name" value="PROTEIN NIPSNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07978">
        <property type="entry name" value="NIPSNAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="181"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="NIPSNAP" evidence="3">
        <location>
            <begin position="286"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY79467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="385" mass="44082" checksum="E8EB232C62CB8478" modified="2018-10-10" version="1">MLAPRLFRPASSLVRPFSSSATAYRAPSIRDITPESATEFNARQKEFRENLEVARKKREQQESQSVDASGSTASSPASRDRPREYATAPTAPHESNASSNRNPMFDAAGVLDHKALGSLSTHRIIGDEQLHEASQSPKRGPLSSLIYGTKEGQQLDKDIERSFSQVLARGKYVHSIVFHDVKPDKVDDYVNLVGQWYPRMASDPENRVNLVGSWRTQVGDNDTFVHIWEYQRYEGYHASLHNISSHPEFPDFDRKLKSLIKSKRTSLMQEFSFWPTTPPRRLGGLFELRSYTLHPGNLLEWETHWRRGLKARREVMEGVGAWFVQIGELNTVHHLWQFANLEERKVRREQSWGIEGWAETVHKTVPLIQTMQSRILIPMPWSPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W319</accession>
    <name>A0A317W319_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase/reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_520974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465546.1">
        <property type="nucleotide sequence ID" value="XM_025610133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W319"/>
    <dbReference type="STRING" id="1450535.A0A317W319"/>
    <dbReference type="GeneID" id="37112276"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="377" mass="40884" checksum="A7F838C35DC0934F" modified="2018-10-10" version="1">MADNQPSPDYSRPQFPAHNEPRVWVITAGDSPIGISVTRKILMHGDYALVGLAHSSLDRDQCRRDMFDAFLAEIESNEGWAERFKALPLDIRMVGECQALVAQAVAAFGRVDILLCCSSQALIGTVEELSASQQTLNLVRDQFESNYFGPLNIIKATLPHMRKQKSGHIMILSGITAHIGTPGLGMYCAAGWALEGFCDSLAYEIAPFNVKLTIFQCSIEIGILTNLVTSVPPISHVYSSAVNHAPLFREILNRLVSRLSADSSNGANQAGSVEDGPFSASEVISTYPPLSSAHMEVLVSETVYAITAIAGHENPPSRHIVGQEGVASVKEKLKTVSEELEDFIQASFAVDYTADEYSRPSREDGISLGMGAGHDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5F2</accession>
    <name>A0A317W5F2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative pyridine nucleotide-disulfide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_567243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465641.1">
        <property type="nucleotide sequence ID" value="XM_025614613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5F2"/>
    <dbReference type="STRING" id="1450535.A0A317W5F2"/>
    <dbReference type="GeneID" id="37116756"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="2">
        <location>
            <begin position="42"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY81573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="450" mass="49863" checksum="36B5277BF5E4D1FE" modified="2018-10-10" version="1">MFRTSIQKAASAALRPHPHPHPVPKPQTFATIAPVTSGQNHKVVVIGGGTAGLSISHQLLRSGRFTPQDIAVVDPATWHHYQPGWTLVGGGLKTKEELRRPMHDLVHPDLKFYNDGVRTFSPEDNTVTLSNGDRVTYEQLVVVPGIQIQYDKIKGLPEALAASDSLVSSIYGYDTCDKVFRTIQQLRKGTALFTQPTGVVKCAGAPQKAMWLALDHWKRKGLYNVDQSQSDIQISFATALPAMFGIPKYSVTLEKLRQKNNVEGLFQHDLVEIDGNTAVFAQPNGQQLVRKHYDLLHVVPKMGPYSFVKDSALANGAGFVDVDESTMRHTRYANVWSAGDASSLPTSKTMAAVAAQAPVLVQNLLRVMDGRDPSRRYDGYTSCPLVTQYGKVLLAEFKYGGVPKETFAMLGIDQAVPRRAFYYMKKYFFPWVYYNSMVKGTWGGSQGWLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W667</accession>
    <name>A0A317W667_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_625702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465593.1">
        <property type="nucleotide sequence ID" value="XM_025617303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W667"/>
    <dbReference type="STRING" id="1450535.A0A317W667"/>
    <dbReference type="GeneID" id="37119446"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12935" checksum="04D89F5F409323C4" modified="2018-10-10" version="1">MVPTVALNLLNFAIVQVTNVTMVHVIASYRPTMGKATVSILAFKAAFGFLLSFYTNPWIDIEGYIVAFGEMACIAGAIIALAVVLFFLGKVLRHRTWKWHVIEKYSHQGSDREMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6R6</accession>
    <name>A0A317W6R6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC multidrug transporter atrF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_153864</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>voriconazole(in) + ATP + H2O = voriconazole(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61912"/>
            <dbReference type="ChEBI" id="CHEBI:10023"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:61913"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465569.1">
        <property type="nucleotide sequence ID" value="XM_025605825.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W6R6"/>
    <dbReference type="GeneID" id="37107968"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001650">
        <property type="entry name" value="ABC drug exporter AtrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="578"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="798"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1211"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1244"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1281"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1321"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1352"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1476"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1502"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="188"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="879"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="843"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY80967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1533" mass="171702" checksum="FDBF971B5CE2F414" modified="2018-10-10" version="1">MADEVRRPDALHNVPTVTQERSDAQGSSHVLASDQTVTSQSTSETDLSLDGRWGEQEAEPVSRRGAMEDFQEMRRELTRLSLHQTRSATRDAQRLRSRASQARDEEKSIDDDGLSGTTESAYGGFDLSEFLLGGHLERRTTAGEPAKKVGVVFKNVTVKGVQTGASFVRTLPDAVVGTFGPDLYNLVCKFAPQLRFGRKPPVRDLLHDFTGAVREGEMMLVLGRPGAGCSTFLKTIANDRGAFAGVEGDISYGGLSAEEQNKHFRGEVNYNQEDDQHFPNLTVWQTLKFSLINKTKKHDTASIPIIIDALLKMFGISHTKNTVVGNEYVRGVSGGERKRVSIAETLATKSSVVCWDNSTRGLDASTALDYAKSLRIMTDVSKRTTLVTLYQAGESIYELMDKVLVIDEGRMLYQGPANEARQYFKDLGFHCPEQSTTADFLTSLCDPNARQFQPGREASTPKTPEELETVFRQSSAYQRILSDVSGYEKQLQDTNQESTRRFEKSVAQSKSKTVSKKSPYTVSLVRQVAACVRREFWLLWGDKTSLYTKYFIILSNALIVSSLFYGESLNTSGAFSRGGALFFSILFLGWLQLTELMPAVSGRGIVARHKDYAFYRPSAVSIARVVVDFPAIFCMVVPFTIIVYFMTGLDVEASKFWIYFLFVYTTTFCITSLYRMFAALSPSIDDAVRFSGIALNVLILFVGYVIPKQSLIDGSIWFGWLFYVNPLSYSYEAVLSNEFAGRIMECASSMLVPQGPGFESRYQGCALTGSELGQTVVSGTRYLETTYQFTRHHLWRNFGVVIAFTVLYILVTVWASEFLSFVGGGGGALVFKRSKRAKQLTAQIGQGSDEENVQGAGVQAQSNSNSETFNRISSSDRVFTWSNVEYTVPYGNGTRKLLNGVNGYAKPGVMIALMGASGAGKTTLLNTLAQRQKMGVVTGDMLVDGHPLGTDFQRGTGFCEQMDLHDNTATIREALEFSALLRQDRNTPRQEKLDYVNQIIDLLELEEIQDAIIGSLNVEQKKRVTIGVELAAKPSLLLFLDEPTSGLDSQAAFSIVRFLKKLSQAGQAIVCTIHQPSSMLIQQFDMILALNPGGNTFYFGPVGPEGRDVIKYFADRGVVCPPSKNVAEFILETAAKATKKDGKSFDWNEEWRNSDQNRKVLEEIKSIREERSKIPVSEQDVQYEFAAPVTTQTYLLMVRLFRQYWRDPSYYYGKLFVSVIIGIFNGFTFYMLGNSISSMEDRMFSIFLIILLPPIVLNSLVPKFYINRALWEAREYPSRIYGWIAFCTANIVCEIPMAIISGLIYWLLWYYPAGFPTDSSNAGYVFLMSILFFLFQASWGQWICAFAPSFTVISNTLPFFFVMTSLFNGIVRPYSAYPVFWKYWMYYVNPVTWWLRGVISSVFPSVDIECASLESTHFNPPPGQTCTQYAGDWVSSVGVGYLSNPNATSDCQYCPYANGQQYMHTLNVHDGDKWRCFGIFLAYVIINWFLVYFMIYCVRVRGWSFGIGYIFSAVGMMFGGIKKLFSRAPKSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W836</accession>
    <name>A0A317W836_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_602574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465169.1">
        <property type="nucleotide sequence ID" value="XM_025616428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W836"/>
    <dbReference type="STRING" id="1450535.A0A317W836"/>
    <dbReference type="GeneID" id="37118571"/>
    <dbReference type="OrthoDB" id="2578740at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="327"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="536" mass="61044" checksum="EE1A2C0B23779C39" modified="2018-10-10" version="1">MPPPVFIATKPIDPPRLGHNNYQGFKKGEREILPKGWNRYRSRPLPCDILVEHDVEIIVRDGARLYCDIYRSPNTGPLNRVPALLGFSPFGKKFSGICMLNSMTPWNVGVPDDHLSGLEKFEGLDPAEWIPRGYAIISADTRGTGDSDGPVVIMGTQEGEDGYDVVEALAKMDWCNGAVGMQGNSHLAITQYFVAMQQPPSLRAIAPWEACSDLFREQFGRGGMWHGDFFDYISSVFIQGYHGMEDFKEMYRRSKGLRNAYWDDKRPDLSKINIPTYLTGSYSSNVHVMGSIRGWLEIASENKWFRLGPWQEWYDLWVEENSTSELQRFFDRFLKDIDNGWEGTPRVRVTALTFGEGDPEYNLVVDDFPLPSTDYREFFFAPHGQLQPELSTDEGISSYDSTTMQSSAFRFVFEKDARLIGLPKAVIYMSCDDEDDMDVFVIIRKLDRQGKKLVALNIPWSRAPVRATDEIQDKDKSDLILYPGPVGMLRASHREIEPSRSIHPQYPFHPHERQLPTPRGQVVGLEIGLWAMGIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8F3</accession>
    <name>A0A317W8F3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_520295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465655.1">
        <property type="nucleotide sequence ID" value="XM_025610101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8F3"/>
    <dbReference type="STRING" id="1450535.A0A317W8F3"/>
    <dbReference type="GeneID" id="37112244"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="141"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY81587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="359" mass="39492" checksum="D87B81AE061C3937" modified="2018-10-10" version="1">MSSPTTWQVGIIGYGFSAKIFHIPFIQHSPHFHLHAVVQRNPTFNNDVTADFPGVVLYRTPDEIVQDPTLDIIIVTTPPDTHFRLTKLVLEAGKHVVCEKPFTPTSAEASELATLATKQGKLLAVFQNRRWDSDFITVSNLIKTGTLGRIVEFETHYDRYQPKPTSTKSWKNQAMAGHGAIYDLGAHVLDQAVQLFGVPARVTGVVGSQREENPSGLEDAFTVLLHYAKGPLVTVKSSVLSAEEEQLRFWVRGEKGSFKKFHVDVQEDQLLAGMRPGDAGFGEESSERFGTLVTVADGKFSKAEYPTDKPPTYAAFYQTLADALAGKGKPAASGEEARDVIRIIELARESSMLGTSLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WAJ3</accession>
    <name>A0A317WAJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RIC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_625587</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466004.1">
        <property type="nucleotide sequence ID" value="XM_025617298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WAJ3"/>
    <dbReference type="STRING" id="1450535.A0A317WAJ3"/>
    <dbReference type="GeneID" id="37119441"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009771">
        <property type="entry name" value="RIC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25440">
        <property type="entry name" value="Beta-prop_RIC1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07064">
        <property type="entry name" value="RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIC1 C-terminal alpha solenoid region" evidence="4">
        <location>
            <begin position="807"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1033" mass="114581" checksum="97707B569A8DF2B2" modified="2018-10-10" version="1">MYWPNGVPRVYAINGPAIPVTPSDDDDSIDYESSTEQELSLRENEPEKPMGTDSAWADEPIAGLCVSRSGFMFATMTSSSIAIWQTRPTAVVAAVARSASSLENYGPNVALLMHPDSTILVVQTLNGYLLTYTIAVGPNTRVYQQHFDQTSSTRRQQLARLTAEEEATGIRDVSIRFRMAIKIESGIAKALALDNELVVATVKPAAIQCIRWTPDADGSQTTSELLSRILGVSKRTSITDMVYDRAINLLVWITNEGQAYAVQRTPDGAPDSESPKKLFQGHCFHNPKNDGEKAMKVAVNARFSLLTVNCANGDILVYTAKDYMGNVPLSHNLQLPASPATTGHLSFMSYSPDGYCLFAGYERGWTTWSVFGKPGGNSFTADRTLAKSNDEDWVTGVSNGCWIGGGAEIILASQDDRRLWILETARSALTGCYSSANLARGLLQTGTEIILYRGHDLPDIMTISGKDSLWHHAQYPPSYLHSQWPIRSSVVSQDGRYVAIAGRRGLAHYSVNSGRWRVFEDSKIENSFAVRGGMCWYGHILIAAIDNDGSYELRLYSREMPLNNQTILHIEYLPSPVVFIGPSGEDSLLVYTYDNILYHYIINSAHSRITLVPVGQIAFHGIVRAPTRVRAISWILPEEQMRNGDPSQDVKVASVLLLVDGNLVLLQPSMSETGELKYDMRVVSHEVEYYILMRDQLSFNFTPSMDESIPPSPAAEMALNMYHSNLSLRDSLWTFCGKELLSWSDVQDVLRREDVAKPLEVPLDFYPLSVLLNKGIVLGVEAEMTQRRDVTFSVLKFAIRTHLFLPYFLQHSLTHGDMPAALSLCQHFSHLSYFPHALEVLLHHVLDDEVDNASKENKADPLLPIVISFLQASLPATVYLDIVVQCTRKTELRSWRTLFTYLPPPKDLFEQALKLNSLKTAVGYLLVLQAFEDEDDDHDSPIEDYVVRLMYLASRKSDWDLCGELARFLIALDGSGDMLQRAVMRAGLRDGSLPGPGLGSGTSVKGLGLAIRTPSWSSLSPTTPLSPRPPDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBQ4</accession>
    <name>A0A317WBQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metal-dependent amidase/aminoacylase/carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_586833</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466251.1">
        <property type="nucleotide sequence ID" value="XM_025615782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBQ4"/>
    <dbReference type="STRING" id="1450535.A0A317WBQ4"/>
    <dbReference type="GeneID" id="37117925"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05664">
        <property type="entry name" value="M20_Acy1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF63">
        <property type="entry name" value="METALLOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="203"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY83783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="422" mass="45470" checksum="F60C1C302FBB6BBB" modified="2018-10-10" version="1">MHMKLTNNLGAILEESRPNLTPFESLYRHIHSNPELSFCEEETSTIAAEHLGELGFEVHTHIGGYGVAGVLRNGDGPTVLLRADMDALPVEEKTGLPYASTKTAKSKDGVEMPVMHACGHDTHVVSLMASASLLLKAREHWSGTLICIFQPAEELVSGARAMLDDGLYDKIPHPDVVLTQHVMPMKAGTVGIVSGRLLTAADSFNVRIFGKGGHGSSPEVCIDPVVTGASIIMKLQTIVGRQVPPGKLAVVTCGYIQAGHAGNVIPDTLDLKLDVRTCEDSIRERVVSSVKQIIRAECESAGCEKEPRIDHVSSTPATINDDATVQALRRTFGAYFEDRLVETDPGNASEDFSLLARAVNAPYVMWTYGGVDPQNWDDAVKNGTVKDLPSNHSPYFAPVIEPTLQTAVDAISLGALTFLKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WC16</accession>
    <name>A0A317WC16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L9-B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_599870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466096.1">
        <property type="nucleotide sequence ID" value="XM_025616335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WC16"/>
    <dbReference type="STRING" id="1450535.A0A317WC16"/>
    <dbReference type="GeneID" id="37118478"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="97"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21890" checksum="EFACBF0014A130E8" modified="2018-10-10" version="1">MRYIYSEERLPIPENVKVHIRSRIVTVEGPRGKLVKDLSHIAVTFGRPEKNVISIEMHHGVRKGIASLRTVRTLINNLIIGVTKGFKYKMRYVYAHFPINVNIEKNSETGLYDVEIRNFLGEKYVRRVTAQPGVEVITSPNVKDELQLSGNSLEGVSQSAADIQQICRVRNKDIRKFLDGLYVSERGNIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WG26</accession>
    <name>A0A317WG26_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_625174</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466576.1">
        <property type="nucleotide sequence ID" value="XM_025617261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WG26"/>
    <dbReference type="STRING" id="1450535.A0A317WG26"/>
    <dbReference type="GeneID" id="37119404"/>
    <dbReference type="OrthoDB" id="1939603at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF3">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="299"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="319"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY84651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="443" mass="47557" checksum="DA6321BB371FFEB9" modified="2018-10-10" version="1">MDNRPASEYAQSGSHFPYPPSAATHHSEPPAADQASAAATAQYTPQPEVRPTPQYTPQPEVRPAANISSSNTPQSDYGLNQPPAARSPAYPEYLARPPQYHHAPNTQAGGAAGMAQATSPSMTTLSDGQHHDHRNHSNLKSDAAVPIDPSIAASSPTYPPPYSPYQPQGHDMAQYQGHPPPPPPQMYTRPEWSHGYGQHQHGLPGPYTTPATTVGPASPAATAGPRPGQVYSFVPIPGAQQHKRPRRRYEEIERMYKCGWNGCEKAYGTLNHLNAHVTMQSHGAKRTPEEFKEIRKEWKARKKEEEAQRKAAEERERAAAAQAAQANQVDAPNPADPAQAGQPPAYPGGVRPQLPPIGYQPADGQVPGQYGAGAGGMVYQGNGQMAYPPNYPHSPYGQTGQVYQTHSLLSGRLATSFALHWDAAALAARPLHGCLSSGPKDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ76</accession>
    <name>A0A317WJ76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_546618</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466970.1">
        <property type="nucleotide sequence ID" value="XM_025613303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ76"/>
    <dbReference type="STRING" id="1450535.A0A317WJ76"/>
    <dbReference type="GeneID" id="37115446"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000102">
        <property type="entry name" value="bZIP transcription factor hapX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="64"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY86379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="485" mass="52252" checksum="BC03169D444AA7AA" modified="2018-10-10" version="1">MATPAPSLAPAPCPAPLAPALAAKPTISPSPGPGTPGSVTSKEWVIPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVNELEDQIKKIEDDHEIHVATFKDQISNLSHEVEQCRSEMAWWRDRCHALEKEVSVERSAKESLVKEFRSSLSDKNSSRADKAPLTRIPARASSAAARVAEEEREEVPLGCSNCSSGHCQCIEDAFGMPGIESASSQSKRPGSSNRLEPEIKPEPEEMEIDFTTRFAAPHHIQDDSVTTVSSPAVDPCGFCTDGTPCICAEMAAQEEERRQRNSFENNRLAPIQNLSQFTPPPSDGDVRSEVTLPPIGQATNPCANGPGTCAQCLADPRRTLFCKTLAASRSASAASSGCCGGKGADGGCCMSRNSNPQRSGSTQQPSSSRRSATPSLTLSCADAFTTLSRHPNFSRASDDISSWLPKLHTLPDPNSNQQEVVQPGSRAALEVEAASVMGVLRYFDRRFADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJG3</accession>
    <name>A0A317WJG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_535936</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466808.1">
        <property type="nucleotide sequence ID" value="XM_025611902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJG3"/>
    <dbReference type="STRING" id="1450535.A0A317WJG3"/>
    <dbReference type="GeneID" id="37114045"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000777">
        <property type="entry name" value="RNA_polIII_C31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY85791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="251" mass="27817" checksum="4F9EEC469A3829C1" modified="2018-10-10" version="1">MSRFGAKKGRKLPGAEFTWEASDPSGEPDTAPTPLFPKYTVPRARPLTATEQLQVDLYRTLRERFHDGPYYSILEGAASASKKESAARASFDPFHGMPSYSGKYVKKKRALPRILGRQYVMKFFPRELWGTIQPSFKPDAAMDGYVPQGARAGVKRGFEDDEEEEDEETAKRTKTGEEGEGAEGDDDGEGDILDAEEEEQGEEEIEDDDFEDDDDEMGGDYNAEQYFDGGDDEYGDDGFGDGGGGGEEDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJK6</accession>
    <name>A0A317WJK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="2">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_597232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467134.1">
        <property type="nucleotide sequence ID" value="XM_025616267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJK6"/>
    <dbReference type="STRING" id="1450535.A0A317WJK6"/>
    <dbReference type="GeneID" id="37118410"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY86543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="282" mass="31800" checksum="368DCEC54AF60A94" modified="2018-10-10" version="1">MSVLQSLRSTYRLNSGHEIPVLGYGVYMIPSSQTEKAALEAFRVGYRHVDSAIMYHNEKACGRAIANSGLDRSEIFFTTKIPPESMGYDRTKRAIDSSLREAQQEYFDLILLHAPYGGKEARLGSWKALVEAQKTGKTRSIGVSNYGVHHLEELEDYIQSGGGGQIDVGQYELHPWLDRSEIVEWLQSRKIVVEAYSPLAHGTRMGERVLTELGKKYGKSPAQIMIRWGLQKGFVPLPKSVTPSRMQENADVFDFALSDEEMKTLHTGEYSPTDWDPTMDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJQ8</accession>
    <name>A0A317WJQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_557043</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467184.1">
        <property type="nucleotide sequence ID" value="XM_025613913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJQ8"/>
    <dbReference type="GeneID" id="37116056"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="220"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY86593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="393" mass="44055" checksum="F34E93498E9FAB77" modified="2018-10-10" version="1">MTAHTQPIETVLTTLNTLTAESFVNDGDRNKALLAAYALVSRLETPWETVARIGMTQPALGASLKVAKGLQLFEKWHERGDNAESSNDLATMVHCDPVLLARILRHLAANHILEETSPNTFKPTPFSLSLLQPIFGEWINFLYDATLPCYLHLPTYLHQTSYTNPTSPTTGIFQSTKNYHGDLFQYYASHPREGASFNHVMGAVMANQASWLDIIPPAHFLENSDPNSPLIVDVGGNIGYDLEKFRTAYPHTAERLYLQDLEPVVKVSKCPDPVVKMVHDFFEEQPVRGSRIYYLHGVLHDWADEPAKNILKMLRGALKAGYSRLLVHDHVVPEMEAHPHATAYDLTMMVMVAGKERTETEWRGLLGEAGYRVVRVWRSALATQAILEAEVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL56</accession>
    <name>A0A317WL56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PHD finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_66250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467257.1">
        <property type="nucleotide sequence ID" value="XM_025617584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL56"/>
    <dbReference type="STRING" id="1450535.A0A317WL56"/>
    <dbReference type="GeneID" id="37119727"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000748">
        <property type="entry name" value="PHD finger domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="465"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="590"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="405"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="845"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY87049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="874" mass="95338" checksum="582729632A7AF84E" modified="2018-10-10" version="1">MAPNLRSSSHAWSNNSRPSTPLGAPTTASTASSFTESTRPRKQRRTGRNSRVATDPLQDPPSRTQSRLEQSRNGTSDTLSESHLLDNSIEWAEPPLRAPAPSYADTPWSAVSSDANPILSTMRPLGAMPSATDLRKAGLAPIKPSVQNISAKKESQATPNGERGDDKPQTPLTPAEEPVAEPVPTKTKTLQDMSVFTALPVPKSTDIDVERIKIAVEKALGLALETNNRPVSRGLLRLWETCNKDPFALSILDGICQENPGPRERSAFQSVMRAAWKEVQAEAGEEFSTAPVLARPRSASSISSLSSAVSFDAETFAPGMTPGATASRARAKGKHAKGSAPQAETEPPSRQSVIPPSAATVPQQKHALEDEPTPEELARIKRARLQKALPNIIASESQLRSSLASERLSNASSPVPATTSRSQAASVGAATSSRERSESPASSDAGDNRRLTPTLTSENERLENNDFCHNCNGSGQLLCCDGCPNSFHFSCLNPPLDPANPPEGDWFCPKCSLSRPITSLLGALDSAPQKDFALPARLRDYFTGVRTGEDGKYEEIVPLPKLNPRGGRGNRTGRYDDPYLLRTVDAKGNLIFCSACGRTSNGRRPIIQCDYCPCAFHMDCVDPPLAIPPTQRPGSDRVHHNWMCPNHVWHDLVYTVQDEEGYDMIKRIRRPKRPRMVDVEVLPDEEDVERMEDQEEEGIMYRVSERGLKLDFIYRVKRENEEYKMMKDAADRYYQYATSEFDHLIAKANAFYSSHKPASSEEDTTAAILNSRTVAEREAAANLITFAQGSQASPGAEDGKIGLLIDQLKANAPHSLPSANTEIASLRALQDLIEQRIEILNAQVERPQPISAEPTDAPSTAAPVTINAKRSHSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WM19</accession>
    <name>A0A317WM19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_624299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467293.1">
        <property type="nucleotide sequence ID" value="XM_025617205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WM19"/>
    <dbReference type="GeneID" id="37119348"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16805" checksum="73D448E78B421FF6" modified="2018-10-10" version="1">MDTVLTNFFQSTSARSRCRIDGMARPHVCDRHRCKTTRLPQEHSSHAGSSWVHDASRHGNDTIEGTRAYSGREGFSSVWSQVLSHRQGFLPGRETRTNNKTCPSPPKTPPTVCACLILFAYRMRFPGAVRLPFPIIRARVFEPAVYEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMU2</accession>
    <name>A0A317WMU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDS1 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_585326</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467629.1">
        <property type="nucleotide sequence ID" value="XM_025615689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMU2"/>
    <dbReference type="STRING" id="1450535.A0A317WMU2"/>
    <dbReference type="GeneID" id="37117832"/>
    <dbReference type="OrthoDB" id="4150221at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057511">
        <property type="entry name" value="WH_GDS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25318">
        <property type="entry name" value="WHD_GDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDS1 winged helix" evidence="2">
        <location>
            <begin position="104"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="523" mass="56353" checksum="D0FB47D4D21EE1CF" modified="2018-10-10" version="1">MPYNTRRKSLSLPSLGIHLPNTSRRSPSATKTPHATDDQLPLSKKVKRSHDSGHSLSPEPSSSSTARTSDGKEHAAPLRQSGRRGPLEHTPPPSPTDGNVSPKIDTEGINDDIVVGVIEQLEKTGNRPHLVKELAAVLIALNENVANSANPAALLSSRLSAYMKRPWTALAPCPLAKELVPIHPRKVYYYLTTLPRQPLPENSDDVIIPGVEGKDLTPSVSSADLDEEDALARERSRLSPSPEVDLSSPDFDEETIDLDGRTGPGGASRSGTDFTDHHHARLMHSTRAASPPLEGDEKEFTQTASAVRERASEKLTSQPQSLGAGFSALSEGLNELHDGTMSISDPVLEDGPLSSISGDRMSDDQDGDYFSHGGYQEQSPLQDHFQQRDLDEAAVATLFGTSPSPSLTSVASSFSSGTSVASDDGLDVDTQSETVGRTPLISLPEDPTVVPVSALKRSIDMLNSGLPDLDMKMSDFNDQEDKLSLGASAFSHQDVEMVFDSWRELQSPETVEVDELDEMFGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN02</accession>
    <name>A0A317WN02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulphydryl oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_466862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467009.1">
        <property type="nucleotide sequence ID" value="XM_025608184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN02"/>
    <dbReference type="STRING" id="1450535.A0A317WN02"/>
    <dbReference type="GeneID" id="37110327"/>
    <dbReference type="OrthoDB" id="4570620at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097237">
        <property type="term" value="P:cellular response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000173">
        <property type="entry name" value="Putative thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000246">
        <property type="entry name" value="Sulphydryl oxidase Sox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050097">
        <property type="entry name" value="Ferredoxin-NADP_redctase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48105">
        <property type="entry name" value="THIOREDOXIN REDUCTASE 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016462492" evidence="4">
        <location>
            <begin position="20"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="27"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY86418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="384" mass="42559" checksum="9A4B03C9A468113E" modified="2018-10-10" version="1">MAPKSLLYTLFSTLSVALAASIPQTDYDVIVVGGGPAGLSTLSSLGRMRRRTVMFDSGEYRNAPTREMHDVIGNDGTPPAQFRALAREQISKYNSTSVIDIKIDSITPVEDTAANTSYFRAVDANGTQYTSRKVVLGTGLVDLIPDVPGLREAWGKGIWWCPWCDGYEHRDEPLGILGGLPDVVGSVLETHTLYSDIIAFTNGTYTPANEVTLAAKYPNWQKQLEAWDVRIDNRSIASIERVQDGDAHRDETGRQYDIFRVHFTDGSTVERNTFITNYPTAQRSTLPDELSLVMVDDKIDTTDYTGMRTSAPGVFAVGDCNSDGSTNVPHAMFSGKRAGVYVHVEMSREESNAAISKRDLEKQTERMVGSEMEKLWKRVLDMHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQ96</accession>
    <name>A0A317WQ96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_73812</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467505.1">
        <property type="nucleotide sequence ID" value="XM_025617634.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WQ96"/>
    <dbReference type="GeneID" id="37119777"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="9">
        <location>
            <begin position="3708"/>
            <end position="3899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="266"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="711"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1155"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1527"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1581"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1619"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1994"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2072"/>
            <end position="2119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2355"/>
            <end position="2545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2597"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2841"/>
            <end position="2945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3013"/>
            <end position="3042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3097"/>
            <end position="3120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="3324"/>
            <end position="3410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1155"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1194"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1584"/>
            <end position="1605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1647"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1664"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2005"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2030"/>
            <end position="2042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2078"/>
            <end position="2089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2102"/>
            <end position="2111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2403"/>
            <end position="2446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2466"/>
            <end position="2490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2502"/>
            <end position="2534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2597"/>
            <end position="2619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="2841"/>
            <end position="2898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3013"/>
            <end position="3026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="3027"/>
            <end position="3038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3109"/>
            <end position="3118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3324"/>
            <end position="3335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="3347"/>
            <end position="3365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="3390"/>
            <end position="3404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY87297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="3913" mass="435282" checksum="8EA9C1E70A9BAD05" modified="2018-10-10" version="1">MGRIKKVASQKHEATISPYLADFVARATTISIPELPSHLNTFSRIWPFPRGDLYHWINVLNRFDEILASVIEKYALSNGPQTKPFGKDFLVESFVHGESAGNSQDVDAKLAELGYGTEGDRELLEVILDFSRLLLEKCGNRSLYSSSERLGELLNTTSLSLLQSTLRLSLCLAQRYHSRQRGGSHIQHSLLAAHYNIDLEKLQKIAAPFPRPSVPGRTAVSPAAVMKPKDKGPQAKHNANDMSSLVRENDGWDEWGNVRLLYYPSGSSEPVKTTLETGTGGPSGQTPTTPTPLRRSHTHPTPRLSRMSTVEDSPSSVVSTPGKPDETLRGGKTLDIPHSKISSSTAEDLIASHADEVPDDSKYELLHRIRTAQGLATSSSTREQILAIRILALTNLAYVYPEALFQQKVLQYDMEQPKRLQLAYQLGELVHLGASGDLQVSRLLQTLALQALDALAKHKARAIDVCAALSVNVNHGVLMFLTRKTVNELGSEDTDGDDGSQDEWRDALLALLRTLPGSSTRTPETLVSAGLIPMFVDVLNLRTEKARRVYSRVMEFLDTFVHAVRDALGTLTSAKGFDAISDLIDHETKTSFEHVSKGSGIPAQHKTPAIDYQIPYFQQQTLRWMFRFVNHIMQHNGGGFDRVLRNLIDSPQLLTSLRLVLENARIFGSHVWSNAVNILSSFIHNEPTSYAVIAEAGLSKSFLEAVTSSELKTPEKPLAEPEDAATEAEPSTLPDTGAAETSADDGQKPRGYTVVRSPDARLAPGIMSAAEALSCIPSAFGAICLNASGLDLFKSSDALESFFEIFENPEHVRSLKDDPSLVRSLGTTFDELVRHHPALKSHVMTAVIVMVARVGLLCRTKAWSVGMGAKLWTEGPEGKPLISGSTSHLLNAIGIENDDQLDNASTFGVPQLTSDQLPNGGKLQLGDLSQILPSPNDAIEPKDVDASGLAATDYLYPVVRFLGAFFENQSNCTYFIESGGVEFVLDFATLQSLPFDFHNTDANQELAVLVHMLAETKPHLVVPSLVERTERAVDMLSVFWREPEYSGFFTPLIKPTSDGVSDDKGKETFSTSRANGTFFAKHMGATLILTDFLREIYSMPLYQTRPSQQTSAFAQVNLADRYCSLVKKLGGLHAACVWEEILLEKNIPDTWDQATKVQQSGMTPERSNPTTGQSNPEPNAAMPGTEPPRESPDASDSAQPDAAQEPKQAPLAKIPEDGVAFKNVQALRYLLSSLPSSITGFFHNMGLGLMGKRRIDLYQKQNATMVAEAVAEAVFEQLQFQPPNSSESSKLRFAYLIVILSSFSHLLFEATPDRPHSHYLTLVLFAFKRHGGLKVIKEICELFVQEVKTLTPPESVAESEKDVSARLTSAYGGIKIILSFFSELASGKNIVESSQTQAMTSSDRDRDRPDFFQPGQFLVDLRMEILPMARDMWNSDFAAQSSSSVVKCLIDILRSSLDGEYETGAAPNSDAPHMLADVARRTFVVNKERVTSLQDKGFDGQLVKEALYRCNNVYAAAEEYCRAQGRLRAPPRAEPPPNDIESVRSTASGAEGSEDAAGDAPSFDSGFLERSALAMLLAQASGRPADDTVRHDQGQARPEESEVRHGTEFLARALTHILNDDHGAGDDDRDDSPIITPRIPNAAGGTSDPSGHAANQPSQQRSDQPTRRREVTTIEDLDKEREQVRSNLIERCLDILNEHHDVSFELADLIASATKRHRDPESFRREVGEILVQSLVSLQMENFQAAGKKVAAYAHLLALVVQDRDMYNATLGELKECFTTFLGFIQVSPEKTSDESFPWIGHVLLVLEKLLSDDAQPPQIRWSLPGHESSGADDEGPAHLEESLVSLDQKTQLYEALVEILPRIGKDDTLALSICRILVILTRSRSIAVRLGEKRSLQRLFVMVKQLSSSTNEKLQGAFMLILRHIIEDEDTIRQIMRSEIVANFESKSSRQIDTTGYVRQMYHLVLRSPEIFVEVSNEKLKLQRYDSRQRPQVLTLKFDKKNSPSDPSTTKTGLDSPNEGESQTGGTASEDKDKDKAKSSDLKPPVVENPDGVIHYLLSELLSYKDVDDKEAPMENTEASAPDQSEPQTDVEMSIDEPSPSVASTDAQAQRNKKSDKPAFKADDHPIYIYRCFLLQCLTELLSSYNRTKVEFINFSRKADPHAATPSKPRSGILNYLLNALVPVGTMEHDESVAFKKRSNTSAWTMRVLVALCTKTGEFGGPGRRRNEQELGEDDEPELAFVRRFVLEHALRSYKEANASNEPLDAKYSRLMSLADLFDKMLSGYAFVSGETAFASSTRQLAKTMFEKHFISALTASVAEIDLNFPASKRVIKYILRPLNKLTQTAVVLSESSDISTLGETEDDEISSATSVSDMEDEREETPDLFRHSTLGMLEPRHEEETSSEESEEEDDEMYDDEYGEEMDYDEDLPEDDGEVVSDEEDEIEGVGPIEGLPGDNGMDIEVVITDEEDDDDDDDEDDESDMEDDEILAGEITGDHDNDSLEGGDEDEWESEEMSEDDEEAEMMNQFEDELADSLRQAEQRDDGQRFDDLFRVLNEAAGGVDDLQADSLGDMHDDIVDDDLAEEEEDEELDELEEELEDADDDQGSYQGFDDDEDLMEPWGWDGDEQPPRGHHHHHRFRGTQPAWAAVSGIMPSRHGIVPIQPYRLHRTQIQARGNDDGTNPLLVRTDRGGPEAGGQPRGPGNEAFTDWVHGMEPVSTGRLLPMDSPVSFMNAIMQAIGGQGAPGFGVITRPDGIHVHVDRRAILPNRIQDIFGLGRPQAPPTRTRDDPSQAVSFALATTRSRWQEEARILFSSSYVEKTQRVVNSLLKILVPPAIEEEKRREKQMEEERKRREEERAERERQERIAREEEERERKRKEDEENARRQQEMEREEAGRQASGIETEPMDDVQRTDTAEEAAVPAIETDTGPSEPVPRVHTTIRGRQLDITGMEIDPEYLEALPEELREEVIMQQLAEQRSQAAAAGEEPSEINPEFLEALPAEIREELLQQEAADRRRRERDSARRQAAAAGGAAIPAPAPVHAEDMDAASFLATLDPSLRQAVLADQPEEILATLGPEFLSEARALPGRRLAQFGDIPRVDHRHRHEPADDQEPKKQQRRQIVQMLDKAGVATLLRLMFMPLQGNARHQLNDILHNVCENRQNRMEVISLLLSVLQDGSADVSAIERSFAQLSLRAKPSSVQKTPQSVKRNLSFQGTSNISNEVTPIMVVQQCLGTLSFLSQYNPHIAWFFLTEHDSSATLKLKALRKGKGKENRANKFALNALLSLLDRKVIMENPNCMEQLSSLLSSITQPLTLLLRREKEKQEEEGKGKMPEPVQGEEPTDEQQPASTELTGSAADTTMTDAPLPTVEATQPQTEPEDVASTEAAAKEDRTKSSGVEEKHKRRTIEPPVVPDQNLQLVVHILAARECNGKTFRDTLSTINNLSAVPGARDVIGNELVSQAQTLSTVILTDLDELLSHIHQARTGTDMQGLALAKFSPASSDQAKLLRVLTALDYLFDPSRADKVKGSETDNAAKEDVLQTLYECSTFGPLWARLSECLTVIRQKENMLNVATILLPLIEALMVVCKNTTLKDTSLSRNSRELSVSSTSVDAGLSMESLFFKFTEEHRKILNELVRQNPRLMSGTFSLLVKNPKVLEFDNKRNYFTRRIHSRGAEPRHPHPPLQLSVRRDQIFLDSFKSLYFKTADELKYGKLNVRFHGEEGVDAGGVTREWFQVLARGMFNPNYALFIPVASDRTTFHPNRLSGVNAEHLMFFKFIGRIIGKALYEGRVLDCHFSRAVYKCILGRSVSIKDMETLDLDYYKSLLWMLENDITDIITETFAVETDDFGEKQVIDLTENGRNIPVTEENKEEYIQKVVDYRLVGSVKEQLDNFLKGKLIPTFTWATRACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQR1</accession>
    <name>A0A317WQR1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Globin-sensor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_595159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468206.1">
        <property type="nucleotide sequence ID" value="XM_025616217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQR1"/>
    <dbReference type="GeneID" id="37118360"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="24"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="312" mass="35204" checksum="B115026B1B64EF7C" modified="2018-10-10" version="1">MSDPDLSENRPRHVDRKALYTDLEARIDYLQKFLDFNADDVAALVRGAKYVKALAPTVVDKVYAKLLEADITARVFRTRNTAVEEEPDDYPTIDSPTVQRRRQFLRWYMTKLCSDPTKPEFWRYLNQVGRMHYGKERLHALNVEYIHIGACLGFIQDIVLEAVLTFEKLTLPFRLALVRALGKVIWIQNDLFARWRLRDGEEFTEEIEALHKQQENGAQVTPKPSSTHLRADCSSCVKTTTASSTSSSSYASVFSEASSAETAPSPPTITTPKPSLQSSGCPFSQMPKQSFETKVWSNAWPSQPVGPGGTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRJ8</accession>
    <name>A0A317WRJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Exo-beta-1,3-glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_464937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467997.1">
        <property type="nucleotide sequence ID" value="XM_025608091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRJ8"/>
    <dbReference type="STRING" id="1450535.A0A317WRJ8"/>
    <dbReference type="GeneID" id="37110234"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016240732" evidence="4">
        <location>
            <begin position="17"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="5">
        <location>
            <begin position="59"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="5">
        <location>
            <begin position="557"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY88635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="926" mass="97691" checksum="CCBFCB725E3113B0" modified="2018-10-10" version="1">MLFVAHVFLLLGLANAVPMPGSLDVASHLAARSSDYWVADIKRQGTVPFGNSTSSYQIYRNVKDFGAKGDGSTDDTDAINEAISSGNRCGANCDSSTTTPALVYFPPGTYVVSKPIVQYYYTQMVGDANDLPVLKAAASFTGMAVIDADPYTSTGANWYTNQNNFFRAVRNFVIDLTAMPSSSGAGIHWQVGQATSLQNIRFEMIKGGSNNKQQGIFMDNGSGGFMSDLTFNGGNYGAFLGNQQFTTRNLTFNDCNTAIYMNWNWAWTFKSVSINNCQVGLNMSASPSNQTVGSVLMLDSTFTSTPTGIVTAFSSDSIPTGGGALVLDNVDFSGSTVAIAGVDGNTILAGGSVVANYVQGNAYTPSSTVNKRSPAVDVQVVTQTVVETILACPAEYGTESAAGSASTAVQAGAESTGTRVMPLPSMSVQYPSGGSYSWAGFDSTAEGSQATNAASVPAVGTSAGPSPAGATGASVVAQGSSSASAANVQASSSASASGSYFGTATNSTGQCTTKTVTKTRLETTIASQAMASSLLTSSGGVFEKSRPLYESYSSSSFVSIKSAGAKGDGSTDDTAAIQKVLDAATDDQIVYFDHGAYIITDTIKVPKHIKITGEVWPMLMAYGDKFSDATNPIPMLQIGEVGDSGSVEISDLILETKGPAPGAILMQWNVQASSQGSAGMWDTHARIGGSAGTELQSDKCMKTPKETTTPNTECIGAFLLFQATEKASAYLENTWFWTADHDLDMSDHSQINIYNGRGVLIESQGPVWLYGTASEHNQLYNYQVSNAKNVFMGLIQTETPYYQANPNALTPFTPQTAWNDPDFSYCTTDSCRKAWGLRVINSTDTYVYGAGLYSFFDNYSQTCLDTESCQENIVEVDCSDVHIYGLSTKASTNMITSSSGDMIVPQEGNESSYCSTIALFEQSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSI4</accession>
    <name>A0A317WSI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_535255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467368.1">
        <property type="nucleotide sequence ID" value="XM_025611740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSI4"/>
    <dbReference type="STRING" id="1450535.A0A317WSI4"/>
    <dbReference type="GeneID" id="37113883"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="282"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY87160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="405" mass="44450" checksum="AA664A6BB4E0B3B9" modified="2018-10-10" version="1">MSDRVLIAGGGLGGLALAQGLRRNNIPFLVLERDAKQDFRAQGYRLRVSQDDLPSLLTPDIWSLFEKTAAIDGPPGSGARLDAVTGQPFPSGALGGGPPPGIHGQLKPFTVDRGTMREVLLTGLGEDVHFGKRFTRYEVKEDCVVAHFSDGSSYEGAMLVGADGARSQVRKQFLPEYPFVDTGMRMIYGKTYITRSLEERIHEKGVEGMSLAVDGDSKAPKTLLFEPMRLPKGEGLGITLPRDYVYWVLLAHRSLIPLPDEETLRLSGEESARLSLALTEEWHPSIRVLFEEQDVTQTSTLRMSSVRPDLPAWEPNPRVTLLGDAIHAMPPTGGQGVNTALRDAAELVRRLVEAKGFGQTGVEAIGKYEETLREYARERVGVSWQGGYKAFNLKSVEECESIDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSM5</accession>
    <name>A0A317WSM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">N-terminal methionine N(alpha)-acetyltransferase NatC</fullName>
            <ecNumber evidence="13">2.3.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">N-acetyltransferase MAK3 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NatC catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_534875</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50524"/>
            <dbReference type="Rhea" id="RHEA-COMP:12713"/>
            <dbReference type="Rhea" id="RHEA-COMP:12714"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133379"/>
            <dbReference type="ChEBI" id="CHEBI:133380"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12711"/>
            <dbReference type="Rhea" id="RHEA-COMP:12712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133377"/>
            <dbReference type="ChEBI" id="CHEBI:133378"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50528"/>
            <dbReference type="Rhea" id="RHEA-COMP:12715"/>
            <dbReference type="Rhea" id="RHEA-COMP:12716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133382"/>
            <dbReference type="ChEBI" id="CHEBI:133383"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12724"/>
            <dbReference type="Rhea" id="RHEA-COMP:12725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133386"/>
            <dbReference type="ChEBI" id="CHEBI:133387"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50532"/>
            <dbReference type="Rhea" id="RHEA-COMP:12717"/>
            <dbReference type="Rhea" id="RHEA-COMP:12718"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:133384"/>
            <dbReference type="ChEBI" id="CHEBI:133385"/>
            <dbReference type="EC" id="2.3.1.256"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the acetyltransferase family. MAK3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.256" evidence="13"/>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467661.1">
        <property type="nucleotide sequence ID" value="XM_025611640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSM5"/>
    <dbReference type="STRING" id="1450535.A0A317WSM5"/>
    <dbReference type="GeneID" id="37113783"/>
    <dbReference type="OrthoDB" id="249099at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000010">
        <property type="entry name" value="Putative N-alpha-acetyltransferase 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044542">
        <property type="entry name" value="NAA30-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45896:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="17">
        <location>
            <begin position="31"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00066994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00076746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY87878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="234" mass="26226" checksum="519C86935AC34EEC" modified="2018-10-10" version="1">MNPPTPDQTTSTSTSTPTPPTKTTPNNLRYIRYNAAQEDAYVPAMRQLISKDLSEPYSIYVYRYFLYQWGELCFMAMDDSLPSPMVGVVVSKLEPHRGGPLRGYIAMLAVREEYRGQGIATKLARMAIDAMVEREADEIVLETETTNTAAIKLYERLGFLRSKRLHRYYLNGNSAYRLVLYLKDGVGSMRTNMDAYAPPQSGPPYPVVESRAEMAGGLMAPEPALLHEGNGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSV8</accession>
    <name>A0A317WSV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_35869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468357.1">
        <property type="nucleotide sequence ID" value="XM_025607158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSV8"/>
    <dbReference type="STRING" id="1450535.A0A317WSV8"/>
    <dbReference type="GeneID" id="37109301"/>
    <dbReference type="OrthoDB" id="4227073at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="183" mass="20369" checksum="AC4BE6E2732F5623" modified="2018-10-10" version="1">MPHLVHHRRRHSWPYCGPGTQLRERRNLPLVIPEQQFLTPVGSEDLLDDDAASAGIVRSNTARPHRRWFAPWESTTPGVASPGAGSGTGSLRKMIRPPLDKARSLFVLPTTTTAGESVLVSYWIPQGAPVTPVPAPMPGRGRVSGSETGTRYLSVERYHRRCHSEQPRAWKRPSASLWPLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUF7</accession>
    <name>A0A317WUF7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mis14-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_491719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467663.1">
        <property type="nucleotide sequence ID" value="XM_025609163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUF7"/>
    <dbReference type="STRING" id="1450535.A0A317WUF7"/>
    <dbReference type="GeneID" id="37111306"/>
    <dbReference type="OrthoDB" id="2135762at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="291" mass="32412" checksum="8B9241E48079B772" modified="2018-10-10" version="1">MTTDHHRKIELQSAADFTYLYANTVALSRQKLDLHLPPSTNPNDGPDPMRERVRELVDEYINRTFTSASSSISINGLDSTSPEFPFPGAFTAPTEQVEYEAYDGKLAARVTSLYAQLESLTTTVAQLRRDAPGRAAKAYAEQLRRAIQEDENEEEEVEEGQGEGEVQEEGLKEESRQSAEGEENRDTEMPDVDANANANANSRKMETTRRRPMTRSRAKLEVPLGTEHEAERWRSGEIAEVYEDALRTLLRLQGELDASAEGPDGNALASTLGKAERAGRAVDVVEKRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVD0</accession>
    <name>A0A317WVD0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-alanine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_555548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468752.1">
        <property type="nucleotide sequence ID" value="XM_025613809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVD0"/>
    <dbReference type="STRING" id="1450535.A0A317WVD0"/>
    <dbReference type="GeneID" id="37115952"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF20">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY90374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="407" mass="44296" checksum="481218D0B725AA8E" modified="2018-10-10" version="1">MFGRTIARQLSPTALRRSVSTSAGSGLQINSDCLLETIHRTCEWVRRWLQDEVEKLDCKVTIDHMCNMFAKQQGSLGSPAPMTAMGSHLDTQPRGGRYDGILGVIAALEVLRTMKEHGYRTNYDIGLVNWTNEEGARFPKSMCSSGVWAGAVPVESAWGLTDIFNPAVTLRSELERHGFFGQGPILEEAGKSVGVVRGAQGYRWLTITVAGRDAHTGTTPLAARRDPLLAASKMIVASNAVAKKYSALASTGVLKLPRSSSTNTVASGVTFTLDIRHPQNHIVHAVQDECLQAFADIAREDGKGVSFHWTLDTDSAAVEFDENCLTAVKNAATHLVGAHKWIEITSGAGHDSVYTSRHCPTAMIFVPCKEGVSHHPEEYCSPADCALGTQTLLETVVNYDRMRREQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVW5</accession>
    <name>A0A317WVW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_565264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468353.1">
        <property type="nucleotide sequence ID" value="XM_025614484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVW5"/>
    <dbReference type="STRING" id="1450535.A0A317WVW5"/>
    <dbReference type="GeneID" id="37116627"/>
    <dbReference type="OrthoDB" id="5346728at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="600" mass="68368" checksum="9916EB94B75D1305" modified="2018-10-10" version="1">MPCQSWPAIPSFFPLLPHPARTSATPKRKRPLRWRPTWFKSYSYIAADTIWNPGHPLHPSDNAMPNLGRGSASLTGMTGALSASNTLERARRQAVYFSRTSIATSLSIHLYLPRDCRQQSVRGNRIRSHQDDFPRKSNFERSRLNFPNSRSSGLYQSYCSVRANVSYSDLADRGSIIAHSLSLPCLFSQDTRFPGSSIALDSSQTTKTAGISSRSPQKLEISRKYQVWSTWMELQQPEHTKLIRPPPGTPQTELLASTSSDQLPISMLIQQAWKGASGSSSANSTKLILLNPSKGRHVDKGRPAENRVHNFTPKARRSAADLHGQLRLQHHSMTSNPYDQALSSSEGGGSSARQKKLVRMHRSDKEFRKDNNQKLNRPLTDKISIQELSNWEIQFIDGLDRKLEWLYNQLSPGRRPYHFAMLANHWLNKETWIVIDPPTRVSIDARRQLGDPRFNVPYPNTDWTPKPKYPKVRRKAAYTPRIDSWRAAVNRNRQVLGLHDIVKVFKLYDDPAGDPPDGKVDPSCWILRKPPQGICMSTRQKQVYYEGGAGWQETLDDWQKVRRGYRIRKAVHEGRANRTRAREIALGISRYYRMVAAKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYT6</accession>
    <name>A0A317WYT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Immediate-early protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_534140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468291.1">
        <property type="nucleotide sequence ID" value="XM_025611474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYT6"/>
    <dbReference type="STRING" id="1450535.A0A317WYT6"/>
    <dbReference type="GeneID" id="37113617"/>
    <dbReference type="OrthoDB" id="5423707at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013268">
        <property type="entry name" value="UTP16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08297">
        <property type="entry name" value="U3_snoRNA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40577" checksum="A7B1CDA25E70E6BB" modified="2018-10-10" version="1">MFSQIVTAAKGLFSRQDSNGASLQNLHSNSGSTSTSTSTGANTPKMVTATRQRKFTAEKPSTEPNANGSAETNGKRKSEPVAAEPTETTQTNTNKRRKRSSLEAAQEPESKPSSKKSKTTEKSEPKQEQASAPVPKKHFRFDSEEPELPEVVAEDTTETRQEVEDSEDDSSDDEAPETVDNSAQRSKIRLEAKKQERAKQIEEQLKRDKRKQLDELRKSQAKIAKKKELKSDDLLSESTETLQGTTTQDARRSALPALLPDDILNAAPDVRPPTPPAEERTFMQQKPNKLRFLDKKEKAPKDVRMGDVTIRVLDGDVSKKSSKTTLPPKASKTGRNAKQNWLNKSRSTGSLNGMRRTTGGSSGFVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ26</accession>
    <name>A0A317WZ26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_534019</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468895.1">
        <property type="nucleotide sequence ID" value="XM_025611444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ26"/>
    <dbReference type="GeneID" id="37113587"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY90517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="69" mass="7885" checksum="DE493C2FC6408D83" modified="2018-10-10" version="1">MLDYHYLSTPAVHTGHVRCLPVEMYVLKYGSSVLAGPGCFGVLYYYGVGSTYLYSVRHWVFYGWPKQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZK9</accession>
    <name>A0A317WZK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_533612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469193.1">
        <property type="nucleotide sequence ID" value="XM_025611364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZK9"/>
    <dbReference type="STRING" id="1450535.A0A317WZK9"/>
    <dbReference type="GeneID" id="37113507"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="2">
        <location>
            <begin position="88"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY91465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="343" mass="38702" checksum="437D89A019C1E969" modified="2018-10-10" version="1">MDNGSPISWLPSTSSRSSSKASSKASKITRNSSPTKQLRNAELEETGFLRADLRNDTKPRSLDALTTGLERIVSGFGILPRDLQDDLADQPSIAAWNFGDSVDFKKSQLPDIRTVRKIYNLASRCFKNNHPESSWNNDVHSRILDWLLRDSPGGDDLIDYRCCLTAQIVPEYQPRKSPSKMVDYCICIQPATNSPQYQAIQSLCKYRPAMSINHTDWADLTKYPIAVSIETKGPSIGYETALLQVATWHSAQWRSLHWDTDGDVLASSGNIDFLPGIVVMQHHWWFVATALNQSGKAQTFERLLLGETESILGIYKLFLSLQRLVNWTRDQYWVTFQTSVLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZS0</accession>
    <name>A0A317WZS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_463564</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468621.1">
        <property type="nucleotide sequence ID" value="XM_025608028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZS0"/>
    <dbReference type="STRING" id="1450535.A0A317WZS0"/>
    <dbReference type="GeneID" id="37110171"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="44"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY89710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="424" mass="48010" checksum="ED0D82E1453BAA98" modified="2018-10-10" version="1">MSKEPRGSTVPHVYVPIEDVEKLERYREGGYHPVAIGDRFHGRYRVVHKLGHGSYSTIWLARDEKRGKLIAIKVCTADSNPRELEVLSLLSRSAQLPGSNWEKTLIPLILDTFKVQGPNGTHACYVTSPARMSLSDSKDASYFRIFRLEVARALVAQLVLAVEYIHGQGFAHGDLHFGNALIQLPPGFDRLSDQELYVRYGEPESEPIARFDGRVLPSCIPSRAILPVWLGEASEDLLLPEANLLLSDFGEAFAPAKENKFDSHTPLVYRAPEARFEAKPLSFPSDIWSLACSIWDIIAESPLFEGFLATEDDMTCEHVDALGVLPSEWWQQWEARQRKFTEDGKPINRKSFRSLQDRFKDSIQDPRQTVGMPPFEPAERTALLSMLRPMLSFKPENRPSAKDVLASEWMVKWALPEYEKVKSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0I0</accession>
    <name>A0A317X0I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_554883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469399.1">
        <property type="nucleotide sequence ID" value="XM_025613751.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X0I0"/>
    <dbReference type="GeneID" id="37115894"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF10">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="831"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1060"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1277"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1317"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="744"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY91671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1491" mass="162776" checksum="F1958C9EBFD2570B" modified="2018-10-10" version="1">MPMNHDTSIASGDRGASRWTLHPEYDPDPHWITIADGDRHWRRASIKDELQGLQQLSSEKALSQLADLLDREDGPWPFQDLLRCYQRVWKGLPEIAKDGSSPEWTMAIDHVQHRLKCVTPHITDLISGNLLQRSLLDPQSGREISHAKVRQFNEDFDLKLPGLITDRKARVAVVLPNGLLLALASLAIAHSYTLVPIAYTAASEELMADVNTAQAEAMLVLEGDVPRFKNMPSLLIYTVQPLDDLTFDVSSVNQAGVPCSAKPAPNGPDDLAIILATSGTSGTKKLVPISMFNLLVMATFTMDSLRLTPESRGLNMMPLRHVGGMMRSLWAPLVAGGTTICCPYFDPNMFWDVVEQYHPTWYYAAPTLHEMIVAEAEHRTNAISRSTITFICNGAAGLSPSLAAKLQNIFRCTVSPSYGMTECVPITAPPPDCDANRTGSSGLAVGPELAIFDTQHPQQHAPPGSVGRICIRGLPLFPGYLTPRGLDRSSFSNGSWFHTGDLGHVDEDGWLYITGRTKEIINRGGETISPVEVEDAIMSAAQDPSSIIFGRVSDALAFSTPHDVLHEVVGVAIALKDCLHQPKWPAVLVYMDALPRSQSKVRRIDLSQRLGLQTLTDHIAAAERHYEADCPPVNTPLHCPIPHRRCEIDPRGVEAYLVQASGMSEILLRAHAVDGYPRAILFRDGRSQIRGHDILALLPDLMHGYLIPSTLEVVNGPIPRDTHGVIDEAAVQAKLHALYPAASSPIQQQVSDLFAAALNSTPEDMTPATDFLESGGDSLRAGRLISQLRQEFQAPLAVDALFRSRTIGAMTAVIKAATADLVRHKASIDELAVQLAMGFICPLLGIALKWLLVGRYKAGMYPMWGPYHMRWWLTQKVLQVCGKGVFNRYNWSRVLYYQALGTHIGRGVQIDESTALGEYDLIHIGDGVVLEHCLCRPFASERNTSMLLQSISIGANCYVGIRSSVVPGTTLLPGTCIGPNSCTWEVDDADESHRDLASAHIPQPHWIWQILVVTPMEIVVAFASALPRLAGLLPIVSRYPTIGEDRLRHTVLWLTNSTRIGYFLLMRLYSSLAGPIIWFLTVVAVKHALDAVCGRPQRGSYGQLPSAQRVRHAVVEAILPLGDISQLARIVGPHYELVSVAVRMLGGRVGKRVYWPRTGLKLTPDFDLVDIGNDVVFGSQSYLITADGTGREPIVIGDGAMLGDRAVVLPGVTVGTRTMVGSGSLLRRNGLYPDDNVWTGSKHGDAIRFPQIKGTFYQGLANYHVLGMGSILGYSNLVVAFTAVYSMVVPLAGLFVLGRLLQTDLLAFEMRWWRPFAVYGMLATAMAAVTLVQTVVSLAMVIATKWLLLGRRQEGSYPIMDDSFGGIGILPSLGGTAYLCWFYRAMGATIGADCALAANGDPHILLTEPDLVTLGDRVTVDDASLFELHLLRVGDRSVLRTGSRLLSGASMGADACLLEHTLVLSGDHVDDGGTMQGWPAEPFMGDRLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0L3</accession>
    <name>A0A317X0L3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469429.1">
        <property type="nucleotide sequence ID" value="XM_025611275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0L3"/>
    <dbReference type="GeneID" id="37113418"/>
    <dbReference type="OrthoDB" id="4457986at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016452304" description="Hydrophobin" evidence="1">
        <location>
            <begin position="17"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="12036" checksum="91AE567690B6121C" modified="2018-10-10" version="1" fragment="single">MKFFAVATLFAATAMAGIVPSEFSWISQTGLTNLNKANAENTCGDNTVMCCTGFTPSTGGFSDSDTVLSKMGRQVPGKVEGGKSCSPCGPDNKGQSVACCTGGSGNLINLPCIAIGSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0V0</accession>
    <name>A0A317X0V0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_461780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469529.1">
        <property type="nucleotide sequence ID" value="XM_025607950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0V0"/>
    <dbReference type="GeneID" id="37110093"/>
    <dbReference type="OrthoDB" id="2787676at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="72" mass="8640" checksum="92FEEEA25312A79E" modified="2018-10-10" version="1" fragment="single">NLRNISFYFNLGDHIREVPDQRPEVKEDATQTANVFQWQATIQAELRSINDWVRKNRFYNIITEFKVPQDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1M8</accession>
    <name>A0A317X1M8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_462405</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469185.1">
        <property type="nucleotide sequence ID" value="XM_025607973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1M8"/>
    <dbReference type="STRING" id="1450535.A0A317X1M8"/>
    <dbReference type="GeneID" id="37110116"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="116"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="337"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="435"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="607"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="670"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="767"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="956"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="670"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="772"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1023"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1043"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY91457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1078" mass="119036" checksum="5B960C0CB2DD9BF8" modified="2018-10-10" version="1">MPWKLSTDTSPEATNRPPLTSQQSNSLPSTPYQHARKISFHSRSPSPPHGSTSPRSTHSESTHLPPSLRKQFSGCKYETAMAFFRRRIPYSLGADLLPEDKEGLKERLEPEEDKRLSADMLEVYDRLLPSAESDDRRRQLVRKLEKLFNDQWPGCNIKVHVFGSSGNKLCSSDSDVDICITTTYKELEHVCLLAEVLARHGMERVVCVSHAKVPIVKIWDPELRLACDMNVNNTMALENTRMVRTYVELDDRVRPLAMIIKHWTKRRILNDAGLGGTLSSYTWICLIINFLQTRDPPILPSLQARPHKKKLTADGIVCSFDDDLDSLVGYGRKNKQSLGELLFHFFRYYGHEIDYERLVVSVREGKLLSKEAKGWHLLQNNRLCVEEPFNTSRNLGNTADDTSFRGVHMELRRAFQAVSEGNLEHCCEQYEYPAEEERSWERPPPQPRPVITAAPPPSRGGRGGGRGGRHSNQFSRGGHSGGRRASNTPNKSNNFRQPNGMTASELSLQAQHAQYLLHDHLYQQIQILQAQEQELRLQLQNQALLTGRPPPVLIRQPFIQFPMPQQQETSSDDNSRSRSGTVNHPPHNTSIRQHVYYSSPYLPVAVPGVQGSNTNPPSPSATAAMPDLRRSPRRSSVANGSPGGSLRAHSQPARTVNSLPSFAPLYSISQLADSSPGSKPRNTPGSPDGTQSDENNTFMPSSLPNVSRSTYFDESRSNEYMGYYLATSPQLQTYHQNALLSSLSSPVGMALQNGGIMPFIGNPQEYMPSMPTEPSGQASDSGTALPTNLGSTPRRTTSRSAASGDRGGPLIVDGSVPPSEQRLSISAEGYDPYTSMSHCTSNSDDLNMDTPASVSDSFSQDYQDNSSVEIDQAPYFGRQGVDTYPLGKTADVYVNGHGGKHSLLSSRLQSLHLSNAEKTPESSLKNGFEKPKMLHIHQEAADRDNPRQRPVNAAEKGVTVSGPLPVVDSHPTSSGKRRPNGVDASERVNGVAHKTKSKNHNTSVGMPDNEKRHAVPQPRKPNGVNSTQDSAVTHAGSGTWQTTKRKPKKNGKHSTEHRHGLNNGAEPLPADESLRKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X399</accession>
    <name>A0A317X399_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Squalene monooxygenase</fullName>
            <ecNumber evidence="16">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_533607</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Endoplasmic reticulum membrane</location>
            <topology evidence="3 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="16"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469186.1">
        <property type="nucleotide sequence ID" value="XM_025611363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X399"/>
    <dbReference type="STRING" id="1450535.A0A317X399"/>
    <dbReference type="GeneID" id="37113506"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="17">
        <location>
            <begin position="181"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY91458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="479" mass="52351" checksum="6E79201189126871" modified="2018-10-10" version="1">MATAVANGHATPPSADAAKQRRLIHHHADVVIVGAGILGCALAVTLGKQGRSVLLLENSMKEPDRIVGELLQPGGVEALEKLGLADCLEDIDAIPVEGYYVSYFGKPVSFAYPKPSPSSPPPQGRCFHHGRFVMKLRAAALACPNVTVVETKATDLVTCSHTKQVLGVQCVTKDMKDCYFGHLTVVADGYASKFRKQYHTNTPQVRSKFWGLELIDADLPKPYHGHVLLSDNAPILVYQIGTHETRILIDIPENLPSASVKNGGVKGHLRNVVLPSLPKSIQPSFVTALEKGQLRSMPNSYLPSAQNKTPGLVILGDALNMRHPLTGGGMTVAFNDVVVLRDLLGPEKVPSLADHQKVLQQLSSFHWQRKKASSVINILAQALYALFAANDENLRALQRGCFRYFQLGMTSGPVGLLGGLIKKPAVLFWHFFSVAFLSLWLVITESPIYKLPLSLFQCIMVFWTACIVIFPYMLIEAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3Y1</accession>
    <name>A0A317X3Y1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_554622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469816.1">
        <property type="nucleotide sequence ID" value="XM_025613730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3Y1"/>
    <dbReference type="GeneID" id="37115873"/>
    <dbReference type="OrthoDB" id="4471293at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13920" checksum="97267356D383D111" modified="2018-10-10" version="1">MVCPSGKAELQRRMMLSFYSDVNIMSDEVSRKLDTDLEPYYGEPIPVVGHPDRNPLGTVKARWTFCGRAKPYRTFFYVVSNVEYDLLIGRPSMRQQELYKADPNIAKRLNASFRGDQDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X413</accession>
    <name>A0A317X413_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_377484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469416.1">
        <property type="nucleotide sequence ID" value="XM_025607234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X413"/>
    <dbReference type="STRING" id="1450535.A0A317X413"/>
    <dbReference type="GeneID" id="37109377"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11539" checksum="9550FD9B695E8D9F" modified="2018-10-10" version="1">MANLALTYWNQGRWKKAEELGVQVLKLRKQVLGPEHPSTLASMANLAFTWKGQGKVKNALALIKQCAELRRNLLGPDHPDTISSSDTLSDWETAVDSVNGCGHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X517</accession>
    <name>A0A317X517_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SNARE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_554436</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470465.1">
        <property type="nucleotide sequence ID" value="XM_025613717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X517"/>
    <dbReference type="STRING" id="1450535.A0A317X517"/>
    <dbReference type="GeneID" id="37115860"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000018">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="179"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY93704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="273" mass="31187" checksum="0D1014AFE86F1624" modified="2018-10-10" version="1">MSFDRLNSLEAQPTTFRRSDDPQYRDDPEFHRLTESLSNRLFTLTSNITRLSDQIALLGTRRDTERVRERVHNLLEQTRLGFKDVGEGIKKVQTWEDVNPSQKWTQQKLSSEFKATLEEFQTVQRRALEKQRASAVAARTAVEDGETTAEGGHHELQQEQQLLEEQPRLANQDEVDFQESLIIEREAEIRNIEQSVGELNELFRDVAHIVHEQGGQLDIISENVERVGDDTRGANVELRSASRYQKNARNKACCLLVILAVILLIIVLAATLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X690</accession>
    <name>A0A317X690_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_532620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470452.1">
        <property type="nucleotide sequence ID" value="XM_025611157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X690"/>
    <dbReference type="STRING" id="1450535.A0A317X690"/>
    <dbReference type="GeneID" id="37113300"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="483"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="824" mass="93026" checksum="11EC67A8DCD81091" modified="2018-10-10" version="1">MPPPNRYQSSPDLRLPPSQRLDTSLPARYTSMSTPDSFSYNASIRRLGSRRARPSAASLADLFVSSLVVAGYCHEHAPRARGLSTVPMNTTGGNMVRWQDRRLAHRRQLSSKHRLDCLGSSAGGLHHSSAQRMINSGVALRVEDDDGDENRFASSPSEGPSFNNRYQGTSTSSTLHQHAGLQESSLETLEDEIPTADTSPTSGDGSTASRITPEGEGINRLSDSSNKPEKYRHCRRTSPTKKTYISTSHVYRAAFGDSLNWKQAVDLVANEPPKGLPSIEVPQKKVDNSRDALEYHSVEVFLDAMWDEKISNHYVFRLYRDLPSPGVACLSKRSRGALLRRFADPPHRRWVDARRYLALVEDMVTAKLPMSLSLWSSAIHLAGRAAGKVRKRDLVKAIGIWQQMEHIGGIKSDGVVFTILFDIAIKASQFTVAERLLEEMKKRNIKFRRFGKVSQLYYCGMQGDIAGIQQAFDGFVSSGEIVDTVVMNCLMASFIRAGDVETAQQLYARMLETQATSHQEGDLSLGSKHPGSSNLTSEMNLYRSRVRKLGRVLQESAPLQGILPEHHRALQNSVRAIPDTRTFHIFLSLHAHHTADIHAFMSILADMEKVFVVPPRGMIYLLLFDGFARNGRHRKGWTAERLQVTWKAYLRALYESRRRLTEMFRIQPEKPVAENTLRHGPVVLEVGWPSISRKPSGLYTPLPLADTAVKESDEVRKQEQQVMDQSDEDVDIDELFKQQAQNPQPEPQALEENERRIENGVFLGRRMVIIILRAFGACCGPEELMKAWLQIERIWQPEKRKAQDVLAVREELERQMNRVQRRYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6I7</accession>
    <name>A0A317X6I7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_622405</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470023.1">
        <property type="nucleotide sequence ID" value="XM_025617080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6I7"/>
    <dbReference type="STRING" id="1450535.A0A317X6I7"/>
    <dbReference type="GeneID" id="37119223"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="47"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="176" mass="20487" checksum="4AA95A413CDFC17B" modified="2018-10-10" version="1">MSTLLHNTVDRLDRPSAYYVGKNKRRKYSQDDTERAEEPADNLKNATTLYVGNLSFYTTEEQIHELFAKCGEIKRLVMGLDRYNKTPCGFCFVEYYTHQDALDCLKYIGGTKLDERIIRTDLDPGFEEGRQYGRGKSGGQVRDEYREEYDPGRGGYGRAYADDQRRREEEEYGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X705</accession>
    <name>A0A317X705_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pectin lyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_582746</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471124.1">
        <property type="nucleotide sequence ID" value="XM_025615497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X705"/>
    <dbReference type="STRING" id="1450535.A0A317X705"/>
    <dbReference type="GeneID" id="37117640"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF18">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016253263" evidence="10">
        <location>
            <begin position="18"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY94363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="489" mass="52376" checksum="A7C0DDEA62CD52DD" modified="2018-10-10" version="1">MMLSPLVLLLWSSLAAGQLIGPVGPTTPLAQKTVECSVLDYGAVADNSTDLAPALESAFSACVLPNPGSRLVVPAGDYLIHRGVVLSNATNWAFQLDGLITAAYGGNWTIDRALILQGFAGVDLLNATINGEGDHKFLLDVLVIVNAVDFEFYSSNGLGAFQGQGYLYRTLDNTDRPRLVRLISPTNASVHDLILVDSPKFHLVLDFAVNVEVYHITVRGANLGSYDGIDAIGTNYYIHDNEVTNRDECVSVKSPSHHALIENLVCNQAGSGISIGSLNVSAEISDIVAQNISIIQGNNIAFIKTYPGGSGYVRNVQFLNFRSKASLYGLDIDQYWQNTFEPDTGAVALSNLTFRNFSGSVADGARRPPLYLIANDLTYATDVTIEDFTVWTESGNDVVNKINNIFGTGDDSYGTNDGIASLAPGATPTTYTSTYTITASPTGWVAPTYPAWAAPSTGYGTASPIPVYTPAALWRPGGVDYDLHYWGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X761</accession>
    <name>A0A317X761_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_343806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470233.1">
        <property type="nucleotide sequence ID" value="XM_025607056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X761"/>
    <dbReference type="GeneID" id="37109199"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16240" checksum="C95FB70EAC0077A4" modified="2018-10-10" version="1">MTTASTPFFSSSAGKHLLRSTPPRHGGFPRDSVPRSLPFRPTKQWERRKATQGPIQASPTNYLPNHLPPEHRHSLRAIYIETTGQPRTGQRNSSSMACPGSCHPRSSDRQATQPCRPPMLFKLSPASGWARYGFRSILFLLFLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7F0</accession>
    <name>A0A317X7F0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_486602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470238.1">
        <property type="nucleotide sequence ID" value="XM_025609012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7F0"/>
    <dbReference type="STRING" id="1450535.A0A317X7F0"/>
    <dbReference type="GeneID" id="37111155"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000005">
        <property type="entry name" value="Nucleolar GTP-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="CP-type G" evidence="10">
        <location>
            <begin position="224"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="476"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="531"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="561" mass="62391" checksum="CAFC58B8B92C9EAC" modified="2018-10-10" version="1">MGTFKKEANRKDRQGKTGDGMGNVRTKGENFYRDAKKLRTLNMLKDGKAQRNAEGKITKAASYQSRDRPVARIEPNRKWFGNTRVISQEALTSFREAVAERASDPYQVLLKTNKLPMSLIRDDKGVNGLKQHQAKMAIETNPFSDTFGPKAQRKRVKLGVASLEDLVGETTKMHNAYVEKSDHATHEDGTMVVDGDDVAADDGSSAAPTAREAVFSKGQSKRIWNELYKVIDSSDVVIHLLDARDPEGTRCRSIEKYIRDEAPHKHLIFVLNKCDLVPTGVAAAWVRNLSKDYPTLAFHASINNSFGKGSLIQLLRQFSSLHSDRKQISVGFIGYPNTGKSSVINTLRKKKVCTVAPIPGETKVWQYVTLMKRIYLIDCPGVVPPNQNDSPEDILLRGVVRVENVENPEQYIPAILKRVQPKHLERTYGVKRTDDPIEFLSILARKGGRLLRGGEPDLDGVAKMVINDFLRGKIPWYTPPPHTSGEEDGKIEGREGRLGEMTRKRKLDETAPEAADETEAAEGQASGSGNEEFEGFGESDDDDDSIANLEISDEESGEEND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7K7</accession>
    <name>A0A317X7K7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 19">Mevalonate kinase</fullName>
            <shortName evidence="19">MK</shortName>
            <ecNumber evidence="3 19">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO94DRAFT_459513</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="18 19">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 19"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470383.1">
        <property type="nucleotide sequence ID" value="XM_025607845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7K7"/>
    <dbReference type="STRING" id="1450535.A0A317X7K7"/>
    <dbReference type="GeneID" id="37109988"/>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000027">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 19" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16 19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15 19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="21">
        <location>
            <begin position="220"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="22">
        <location>
            <begin position="391"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PWY93622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="539" mass="58545" checksum="484A845097792675" modified="2018-10-10" version="1">MHNGRARRKNGSIRASKAGQRRNMSHLIPDQVPLARPKTVTVSDDSPDISDAASNTSATTVITNTSSPSASSPTNGVDSVKKAMARKASSPMAPPFMVSAPGKVIVFGEHAVVHGKAAMAAAISLRSYFLVTTLSKSQRIITLNLRDMDFNHTWNIDDLPWDLFKQSSKKKYYYDLVTTLDEELYNSLRPCVEDVSPNAPEELRKKHKGSALAFLYLFCSLGSPQNPGAIYTLRSTIPMAAGLGSSASVCTCFSAALLLQIRTLAGPHDDQPPDEAELQIERINRWAFVGELCIHGNPSGVDNTVSTGGKAVIFRREDYSKPPKVVPLPNFPELPLLLVDTRQSRSTAVEVAKVGKLKKEHPLVTGTILDAIDKVTLSAQEAIQGTDGKSIDNETLEQIGTLVRVNHGFLVSLGVSHPRLERIRELVDFADIGWTKLTGAGGGGCAITLLRPDASEEALRKLEGQLAEENFQKYETTLGGDGVGILWPAVLRNGSDEEGGEEIDQQKFENADGPEGIERLVGVGAQERREGWKFWKRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7M9</accession>
    <name>A0A317X7M9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_279712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471374.1">
        <property type="nucleotide sequence ID" value="XM_025606616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7M9"/>
    <dbReference type="STRING" id="1450535.A0A317X7M9"/>
    <dbReference type="GeneID" id="37108759"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000619">
        <property type="entry name" value="Oxidoreductase, short chain dehydrogenase/reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF12">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_6G13830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="263" mass="28240" checksum="536B4F27E20408AA" modified="2018-10-10" version="1">MVLSKPENKHVLKAFDLTGKVAAVTGGARGIGLEVSRALAEAGASVALIYNSSKNAEALAEEIAATNNVKTAAYKADVGNQEDIEKVIQQIASDFGRLDIIVVNSGVTSNIAAEDYTSEQWRDIMKVNLDGAFYSAQAASRIFREQGHGNVIFTASVSATLVNVPQKQAAYNASKAAVVQMAKCLSVEWVDFCRVNCISPGFIATEILDIHPQEWREKWNSMIPAQRMADAHELKGAYVFCASDASSYMTGANIVIDGGYTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7P3</accession>
    <name>A0A317X7P3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Synaptic vesicle transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_325110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470982.1">
        <property type="nucleotide sequence ID" value="XM_025606929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7P3"/>
    <dbReference type="STRING" id="1450535.A0A317X7P3"/>
    <dbReference type="GeneID" id="37109072"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="64"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="501" mass="54362" checksum="9206DD0A83FDE780" modified="2018-10-10" version="1">MSLHSSTTDVEKQAGREQASQVHELNRSQVSGLAKRNDAVTVDWDGPDDPENPLNWPTGKKARQLVLLSCNTFITPLASSMFAPGLRGVMSDFHTTNDMLGSFVVTVFVLGYMVGPFVVAPLSEIYGRVPVYHVCNVLFLVFTVACAVAQTLPQLIVFRLLAGVGGVCPLTIGSGTVADMVPLEKRAGIMSIWALGPILGPVVGPVAGGFLSEAEGWRWVFWVIAIATGVITIGCIFYYHESYAPVLLERKATRLRKETGNSNLQSKYYTGPFTTQSYLNTLARPMKLLAFSPIVLMLSLFAAITYGYLYLMFTTIPPIFKNAYGWSTGVAGLSYLGFGIGSVTGLVSYGVVSNRLAVQHTARGTFTPECRLPPMAVGCWFVPIGLFWYGWAAQAHTHWIVPIIGTGVFALGLMTVFIATNAYLVEAYLKEAASVTAASTVLRSLVGAVLPLGGPAMYDRLGVGWGNSLLAFMALALCVCPGLFWRYGERIRTHPRFQLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7Y9</accession>
    <name>A0A317X7Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_531673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471497.1">
        <property type="nucleotide sequence ID" value="XM_025610951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7Y9"/>
    <dbReference type="STRING" id="1450535.A0A317X7Y9"/>
    <dbReference type="GeneID" id="37113094"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="307"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="379" mass="42426" checksum="281F44163FE9CF8D" modified="2018-10-10" version="1">MNAGWRWVMGFLGAFSGVVWIIGSLTVPETYAPVLLRRRAERLSKLSGKVYQSKLDIDQGKTTLKQAFKVALSRPWLLLFKEPIVFLLSLYMAIVYGTLYMLFDAYPIVFEEYRGWNQGVGSLPFLGIMVGMMAAVAYNIFDNKRYIRTQEKHGGFAPPEARLPPCMVASFAVPIGLFWFAWTDAPSIHWMASVAAGAPFGFGLVLVFLSNLSYLIDTYTIFAASVLAANSVMRSVFGAVFPLFTTYMYENLGIHWATCIPAFLALACVPFPFLFYKYGAAIRTRCKYAAESDAFMRNMLAQFAKQPEPQEEVQADEKFDRTEAPAAEVDAGDSDSSTEQLPAVHRINTKASTRSAKQSLYEGSPYDIDRVNTRESFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7Z7</accession>
    <name>A0A317X7Z7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TFIID-18kDa-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_509389</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SPT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471484.1">
        <property type="nucleotide sequence ID" value="XM_025609699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7Z7"/>
    <dbReference type="STRING" id="1450535.A0A317X7Z7"/>
    <dbReference type="GeneID" id="37111842"/>
    <dbReference type="OrthoDB" id="66982at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22926">
        <property type="entry name" value="HFD_SPT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000023">
        <property type="entry name" value="transcription initiation protein SPT3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF16">
        <property type="entry name" value="TRANSCRIPTION INITIATION PROTEIN SPT3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="249"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="324" mass="36989" checksum="C21736A0C886C406" modified="2018-10-10" version="1">MSTDRTPKYRQEIQQMMFVSGETAEPAVDTTTLIEEIVRQQVVEILARSTALATRRGVRSISTDDLIFLIRHDKAKVSRLKTFLSWKDVRKNVKDSDDKGGADAADFAAADDPIAGGVVAGPQDVASKPKNKRARVGLAWDVNSFYSVQVPEREDEEDEEEEEQNYATLQRLAAADERTKNMTKEEYVFWSECRQASFTYRKSKRFREWAGFGIVTESKPNDDIVDILGFLTFEIVQTLTEEALKVKEREDREKNRRGGAENGESIKKRKRETGLFDPPEEGRTPVEPRHIREAYRKLQATPNKNIAMLLHNGRLPARMPLRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X828</accession>
    <name>A0A317X828_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_621233</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471535.1">
        <property type="nucleotide sequence ID" value="XM_025616988.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X828"/>
    <dbReference type="GeneID" id="37119131"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19532">
        <property type="entry name" value="C_PKS-NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="8"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="951"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2426"/>
            <end position="2505"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3645"/>
            <end position="3726"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="951"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2509"/>
            <end position="2622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="2509"/>
            <end position="2523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2540"/>
            <end position="2551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2558"/>
            <end position="2570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="2594"/>
            <end position="2605"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="983"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY94774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="4095" mass="445237" checksum="7E4D23D80C20B176" modified="2018-10-10" version="1">MTKQDYLEEPIAIIGSSCRFPGGASSPSKLWDLLHDPRDVLKEFDPDRMNLKRFYHTDGEHHGSTNVTNKSYTLEEDTRVFDAAFFGITPMEARGMDPQQRLLLEAVYEAFESAGMTLEQFKGSLTSVHVGVMTSDWTNIQLRDPETLPQYAATGTANSILSNRISYIFDLKGPSVTVDTACSSSLVALHQAARGLLDGDSETAIVAGVNIILDPTVYITESKLHMLSPDARSRMWDKGANGYARGEGTAALVLKRLSQALADGDDVEAIIRGSGVNSDGQSPGITMPFAPTQAQLIRHVYRRAGLDPSRDRPQYFECHGTGTPAGDPIEARAISEAFSTDSGAISTNDPMYVGSIKTVIGHLEGCAGLAGVMKSVLAIKHRVIPPNLHFNELNPAIAPFYGPLRIPTTPVPWPKLHPGEPARVSVNSFGFGGTNAHAIIESFEDNTAIAQQPSNTAFGPLLFSAASGTSLLATVRAHLQHLKKHPEVNLSDLSSLLQTRRSTHRVRAHFSSSSRDDILASMEHWVTSNEKIPSGQIGYHPRLLNPSEVPGVLGIFTGQGAQWPAMGRELLDRSPVFCQTIADCEAVLRTLPAKDRPTWSLERELRADAASSRISEAAICQPLCTAVQIGLVDILTVAGVHFDAVIGHSSGEIAAVYASGIINRAAAVQIAYYRGLHARLAQGGQGQSGGMLAVGVSLTEATQFCSQPRFGGRLSVAASNAPQSVTLSGDLDAIREAKDSLDADGIFARHLKVDTAYHSHHMQPCSDPYLQSLLACNIEVKKPAPGKAIWSSSVRGDTELLNGDLDDLKGSYWVSNMLQTVMFSQALESSIWHGGPFDLAIEVGPHPALKGPVEQTLKAVHGPVPPYTGLLKRGASDMGAFSTAIGSIWAQLGPSALDFAGFRRALSGDGGNTRAALISKDLPAYPWEHDKLYWRESAISRRYRIGDDVGHELLGRPCADSNPHELRWRNILQLGEIPWLRGHEVLGEVLLPAAAYVSLALEAGQQMASRAGRAVKLFEVENIDILRPVVVPDNKDGVETVFAAHLSEGLNINPIRARISYYVCPDQGKGTMVHVCNGALVVHLGELPKEEPVLPPRQAASRNDLVEIDCDRAYNMFHNVGLNYAGSFRAMTQSKRVLGYSTSTAVWSSDSLSDNMILHPAMLDVAFQSLFVALAHPASGQISSALLPSRVERVRVAPHLQQRPVGVDIGADIESWVVQQSATSLVGDLNVYDCASGLTFAQVEGLTLNMIGEQDSSQDRPMFAQTVWAPDIANGWPEVLRDDVEDAKVLRQAEDFERVALFYSRRLAEEIATDERSKLQWYHQRMLTMNDERLGLIKSGQHPIIRSEWLDDGPEALEKIDQIHGNPVQLRLLHAVGSRYPRILRGEVEQLQVMNQDNLLNRFFTEDLACLRVNQLLADAAHEITFKYPRSNILEIGGGAGGTARTVLNKINDAYASYTFTDISSVVLAQASETFADFASKMKFATLDINDDPSAQGFAPNSYDIIVASNVLHATKNLQSTMNNVRSMLRPGGYLLISELTGMEGLSKPFLFSGLPTWWIGEEPDRQMQPIVPILRWDEVLRETGFSGIDMELHDTADEATQSSALLVTQAISDSFLHLREPLLTISANPAPVDGLVLIGGKKFPTTKILTAIQKLLPQSWRGYVRTISSVDAVETLADVGPNMDIICLHDHDEPLFASTITESRLTALQGLLMRARNLIWATSATNGHSHPPRATMIHGISRIMPVEMPHIYFQVLGLEAGLSPSVAAQHCLEAYLRVKETRQELAENPGNVPMEGKLLWAREPEVEVLKNGTVIIPRVIPDHTLNSVFLAAKRTVTQSLDATHQPVQAVAGSTRMTIQAINPREGSSPGTVPVQVEFALHIPARNGDGVYLISGRSLDSLDTSIAASEVNASVVHVPTSRPEKIASELSRPAVLFAAANHVLSRTIADLASPGKPILVYGAEPAFASGIADELARRGIHPYFASSESDAPDSWIKVHAQSSKRAIKRILPHDVAVYVDLSPSPSSIGDHLRGSLPTNCTTVELDRQLLRRAFLDDALRASAMLGKSHAEAHKQGADTELSCEVIEAPELANATVASLETKYYVTDWRKRDSLTVTVPPLEPRGLFRPDRTYLMVGAAGGLGLSLCKWILEHGAKHLIITSRNPTVDPAVLEDARRVGASIHVLPMDVTDRASIERVVQHARDTLPPIAGVCQCAMVLRDRLFLDMSIDELNGTLAAKVDGTENLDAVFGDAELDFFVMLSSSATAIGNIGQANYHIGNMFMTNVAAQRRARGLAGSVIHIGHVTDVGYIVKTKERTDQLAEHFGSIRMMPLSETDVHHAFAQAVRNGRPGSQLSSDIIMGIEPPSKPSPRGLTDDSIHWLKNPRLSHMTPIASLDGGANGNGQTVPSALGSVCQRVEDAETEEKAVSVVIDAFCAKLDKTLQLPDGRAAENADRAVIDFGIDSLVAVEIRNWFLKELSADVPVVKVLGGDSVLQICTTAARTVLARSMRDERKKPKADKAVHSATPAPPELPVSALQAPCVSSVPVSAAPVPPPATTITTSADAIPTPGEHRPVLVGMKSSSTIQDENWEDSAASSPELGSSSNTSLHELEGSASPLSEVISEEDLAKTNETKLDAGKAAARPVVVREERMSRAQARIWFLSKHARDPAAYNMVFHYQVNGKLNMMRLRRALEMTTDHHECLKMCFYQRVGDGQPMQGLMKSSAYQIEHITDGKDDDLKQVMACYKTRVWDLEAGQTMGVAVISRSADKHDFVFGYHHIVTDVVGWLMFLQTLDPAYRLHPLSRDQTVSHIEYTRREQEQEAAGRYTQPLEFWQKEFATLPEPLPLLPSASVRTRPTRQPQDQDIRKIQSQYRTLSPDVVAMVQATCRRLRVSPFHFYFAVLQVFLTQLAGIEDVCTGIVDANRGYDELAARMVGCFVNVLPVKGRVARGDTFAGVARNASRKALETFAHAGVPFDVLLDALNTPRWADGDTAPLFQVAINYRAAGWGELPLGADCRMALTLDDGKDAEPPYDISLGIMDLNEGCTLDFHCQGALYSAEATAEMSDSYVRLVEAFAANPDMVVEDSPVYDGARVSQACELGRGPEIDFSWPATLSQRFKDVCRLHGEDPAVIDDTTTLSYDELAPRVDSVSMALKSAGCVAGDRVAVLCEPSVDSVIALLAVLQSGCVYMPLDTSLPAARHAAMIRTAEPSLLLYNTSLEDVVLQLAEESIATFQEICIDDVTETSSGADMPCPSDPSAPAILLFTSGSTGTPKGILLTQGNFVNHLALKVKVLGLGQEQVLQHSSLGFDMSVVQTFCALANGGCLVVASRHKRRDPVALTSLLHKHRISLTIATPSEYLAWCRYGSSSLREHVAWRHACMGGEPISLQLRKELLLLGLKGLQFTNCYGPTEITAAATFQLLSLDDPISSTSGETEQQLRLKHAVGKALPNYTVRIVDSTGRPQPVNHNGEICIGGKGVALGYFGLPTETAHKFFIDLQTGQRLYRTSDQGRLLPDGTLLCFGRLEGDTQVKLRGLRVELEDVEAALLRAAGGLLSSIVVSAREEILVAHATVASSLNRSVSDSELAGILRRTRLPQYFIPAAIIVLHALPTNANGKLNRKAIAGLPIPTSGVNNPGEAQEEVTMNIQQGELRLLWERVLPASSAATFGRITPSSDFFLRGGNSMLLMRLQTVIRESMGVQVSTRDLYRASTLADMAKTVFEGRQRAAAANGDPEDIEWATETAIPEWLKQRVQQLTPLPAEPKTDGLQVVLTGATGFLGGRILQTLLQSPAVQKVHCIAIGVDDTHAIPQDKVQYYQGNLADPKLGITEDEHALLERTADVIIHAGSHGHCLNNYATLQAPNVAATHRLAALALPRSVPLLFISSNRVSLLAGQTEQPPVSMANFAPPVDGREGLTATKWVGESFLESLHDYYTRHQQKQKGTQPHRPWSVAVHRPCIVVGDQAPNSDSMNAILRFSLMMRCAPLVKHGRGYIDFKPVDEVAADIVEAAMRMTRASADDQRVQFLHSTSGVKVPLDGFREHLEKVYGGQFEAVEMQEWVGRASKAGIDPLITAYLNGVMDTDEEMVFPYLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8H8</accession>
    <name>A0A317X8H8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BO94DRAFT_507641</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471665.1">
        <property type="nucleotide sequence ID" value="XM_025609626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8H8"/>
    <dbReference type="STRING" id="1450535.A0A317X8H8"/>
    <dbReference type="GeneID" id="37111769"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 24" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="115"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="269"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="528"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="629"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="710"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="757"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1131"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PWY94904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1226" mass="137623" checksum="2CAA60124F75A470" modified="2018-10-10" version="1">MPPRRRAPISAANLRSAQPSEAAASAKPGATDPSSKRRRPSQTAQPSKPEQPPPPPTAEQQQQEPTEEHSHSSYRHRDPFDALLQPFYYNKSLTDPINTAKDKWNLLPAFLKVKGLVKQHIDSYNYLVEVQLKKIVESSSTIRSDVDHTFYIKFTNIYLGFPRRADEPQDARADFTYSTVSPQECRLRDTTYAAPIQVDFEYVRGRQRVMRKGVAIGRMPVMLRSSKCVLANKTPAEMSVLNECPLDPGGYFIVNGTEKVILVQEQLSKNRIIVETDPKKEIVQASVTSSSNERKSKSYIVLKKDKLYVKHNVLSEDIPIVILLKAMGIHTDKEMMLLVAGVDKVYQEDFAINFEEAINLGIYTQQQALDWIGSRIKINRKQSPTYRRTHVQEAVEAIASVIISHIEVKNMNFRPKAIYVAHMARRVLMAKNDATLVDDRDYLGNKRLELAGQMLALLFEDLFKKFCFDIKMNIDKVLNKRNRAEAFDAYSVITMHSNHITQGMNRAISTGNWSLKRFRMERAGVTHVLSRLSYIAALGMMTRISSQFEKTRKVSGPRALQPSQFGMLCPADTPEGEACGLVKNLALMTHITTNDEEGPIRNLIFMLGAEDIQTVGGKELYGPGCYTISINGTPTALTRRPKYFLDAFRRLRRMGRISEFVSIYINHHQRAVHIATDDGRICRPLIVVEKGKSCVNTQHLEKLRDGSMEFDDFLAQGLVEYLDVNEENDSLIAIYEKDITDTTTHLEIEPFTVLGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIASNQFLRIDSILYLMVYPQKPMVKSRTIELVKYDQLPAGQNAIVAVMSYSGYDIEDALVLNKGSVDRGFGRCQVFRKYVTNLKSYSNGTKDRLSGPQYENDAPIRKHALLESDGLAAVGEQVNAGEVYINKSTPDQSMASGFPSSDAGRPVSYMPTPMTYKLPDPAYIDKVMVSVTENENQLVKVLTRQTRRPEVGDKFSSRHGQKGVVGIIADQADMPFTDLGINPDIIMNPHGFPSRMTVGKMLELVAGKAGVLAGHHGYGTCFGGSPVQEMSQILINNGFSYGGKDYLTSGITGEALPFYVFTGPIYYQKLKHMVQDKMHSRARGPRAILTRQPTEGRSRDGGLRLGEMERDCLIAYGTSQLLLERLMISSDRHEIDVCEQCGFMGYLNWCQRCKSSRSVVKMAIPYAAKLLIQELMSMNVTARLKLDDEFPEMKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8L4</accession>
    <name>A0A317X8L4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_313489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470678.1">
        <property type="nucleotide sequence ID" value="XM_025606843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8L4"/>
    <dbReference type="STRING" id="1450535.A0A317X8L4"/>
    <dbReference type="GeneID" id="37108986"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF15">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="34"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY93917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="474" mass="50835" checksum="0BAC116940F84638" modified="2018-10-10" version="1">MAEPVYNASTPEGGDPTKVDVNAQYAGYEYNYVYIVTCTFIVFFILPGIGMLYSGLTRRKSALALLFQSFMVLAVSTFQWLFWGYSLAYSRDGGPFIGTLKNFGLMDVLVAPSPGSAVLPEVVFCLFQLLFCACTVMIVVGGAFERGGIIPSLIFSFFWATIVYCPLARWTWSSNGWLYNLPAIDFAGGGPVHIASGCTALAYALVLGKRRDYGEPSLRKPHNTTLVFLGTVLIWTGWLGFNGGSSLNASMRAMVAVFNTNTAGCMGILGWVLVDMIKYKGKFTMVGACEGAIAGLVGITPAAGCVSLWLAACIGFITSVVCASLQNVNEWIHVDEGMDVFKLHGLGGMVGAFLTGLFASEKISALDGSSLSPGAIDGNGVQVGKQLAEICAIASYSFVVSYIMLLILRYIPGMEFRVNDEDEMLGLDQTKFFDEQIGDWSMMAHGTATPTLVGVSKDSSASVTECGERKTSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8V2</accession>
    <name>A0A317X8V2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutathione transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_507923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471795.1">
        <property type="nucleotide sequence ID" value="XM_025609640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8V2"/>
    <dbReference type="STRING" id="1450535.A0A317X8V2"/>
    <dbReference type="GeneID" id="37111783"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="366"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="450"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="598" mass="67142" checksum="A3064EF8B3A02BF8" modified="2018-10-10" version="1">MDHPSLASEADTALHTAASTLLHPSLTSVAEDASTLAAQHQDPQLDPSQGQDIDEDSLHGLQCAVEGLDYSRPSQHPQQQHDLNHHHDQQPHLQSLVKRPDQHVDIRTIIDPPDLDAWRERLFNVDEMIVLSEEQFLTYFPHIDNVYSHRSTQHYKRKPLISHYWDCRLKGRPPGTPKSNDPNKKKRKRTARQRDLCDVKIKITEYFPGHDVMGSSGTDAGLSVLGVGVSGSLPGAGGSMLHPTAESGLRDQQNQPFGLLTPSLNPPLPEGHPGVNGQRFFTIQRVNGNGANGKNDGVSGGHRHTLEESDRVKKNSVQRYLLKEVREKKRSLSTRAMATQNETQKQYHTKATGLAARTVANRSQDDELKLYGSCFCPFVQRVWIALEVKGIPYQYIEVDPYKKPQSLLDVNPRGLVPALRHGDWGSYESSVLLEYLEDLNVGPPLLPPGDAKLRAHCRLWTDFINRHIVPNFYRVLQEQDTQKQIANAQELRDAFNTLVTAADAQGPFFLGPRVSFVDVQVAPWIIRLRRALKPYRGWPDPEPGSRWGAWVDAIENNEHIQATTSTDELYLDSYERYAQNRPNTSQVANAINSGRGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA86</accession>
    <name>A0A317XA86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_531046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471902.1">
        <property type="nucleotide sequence ID" value="XM_025610810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA86"/>
    <dbReference type="STRING" id="1450535.A0A317XA86"/>
    <dbReference type="GeneID" id="37112953"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="36"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="162" mass="17980" checksum="2CDC492DD471D7B2" modified="2018-10-10" version="1">MSLSAPLRRSAATTVRVQTSTTFICSQCRHATLLRRPKRPYQFTQLITMTDGSTFTHRTSSPVPVYRSTRDTRNTLLWNPTSSKLKSVEDDEAGRLAAFRAKFGRSWDVNTPVEGAESKTDQPEKSKEAAAAEAAAAEEEDDNLLDLISSFGQEEQQPGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBE9</accession>
    <name>A0A317XBE9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_620253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472647.1">
        <property type="nucleotide sequence ID" value="XM_025616919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBE9"/>
    <dbReference type="STRING" id="1450535.A0A317XBE9"/>
    <dbReference type="GeneID" id="37119062"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000051">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF886">
        <property type="entry name" value="UPF0676 PROTEIN C1494.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="179"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="372" mass="40876" checksum="E123BB300B7A8049" modified="2018-10-10" version="1">MTDVGPPIELPVLDISNPLDPAAGKALLDAATKYGFLYVDSRGTDFTAAEVDRAFELSKTFFASPVEEKAACRIESNNRGWSGMHTETLDPEHQRTGDFKEAFNFGEFANSQAQQPLPPSLHPHESEIAHFSSLCNKTCTRILTLLALGLDIPKDFFTTRHDPTTGPTGSILRYLYYPSLTSPTTTTYNHTLDVRAGAHSDYGSITLLFQRPGQPGLEILTPSGDWAPVPVIPSPNVSTSQGETYPFPPILVNIGDLLSYWTSGLLKSTVHRVVFPMAEQQQQESEEGSAQDRYSIVYFCHPMDRTELVPVPSKVVGEFRERMKREAREGRRVGFGGGAGVLGEGGDNGDGRVLTAHEHLMARLDATYGFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBI6</accession>
    <name>A0A317XBI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_601035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472755.1">
        <property type="nucleotide sequence ID" value="XM_025616365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBI6"/>
    <dbReference type="GeneID" id="37118508"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="172" mass="18654" checksum="226C6FB98F96485F" modified="2018-10-10" version="1" fragment="single">LKQIIKNPSPNTALFKRSPATSRPSGESLPISSLAFRSKSTVLTTLISTLHPKTTNNSLCETTPSCTLTGIFSVCARFLTIHTTACPTPRVVVVLNFPSPSSYNGVTRPDKSNNSSVFNPKSSHGLVKSNVYVSPERCATSRRWSWMVILSMKMGRVEVAGWVVSQPNSDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBN6</accession>
    <name>A0A317XBN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_271899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471139.1">
        <property type="nucleotide sequence ID" value="XM_025606569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBN6"/>
    <dbReference type="STRING" id="1450535.A0A317XBN6"/>
    <dbReference type="GeneID" id="37108712"/>
    <dbReference type="OrthoDB" id="5598057at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13311">
        <property type="entry name" value="PH_Slm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046868">
        <property type="entry name" value="BAR_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046869">
        <property type="entry name" value="SLM1/RGC1-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043453">
        <property type="entry name" value="Slm1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941">
        <property type="entry name" value="CYTOSKELETAL SIGNALING PROTEIN SLM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31941:SF16">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE-BINDING PROTEIN SLM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20400">
        <property type="entry name" value="BAR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20399">
        <property type="entry name" value="PH_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="428"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="626"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="746"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="770"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="832" mass="91626" checksum="30B58C6C25EC3F60" modified="2018-10-10" version="1">MAMAVRSQTPVQDTYGSIPHPPDLLLNRGYSVRSSSRPNSIVASTSGYLAHGANPEPAPFTHNGRFHEEFDAASHRGSLDGRPVMQRSASQMSQSRSATPTRSSTLKKKASLSKRSSMRRSGSKRSLRAGSVRSLVLGDKEKYGADGEDPNSAFYIPIPTNGNPTEVLANRFQAWRKVLKDLIIFFKEVQKSYETRSKLFLSASNIMQNTSLPPTFLKSGGLSDATDILRDFHRQGYLEANKAAEVESEVVNQLMGLRNDLQKKTKEIRSLSGDFRNSVDKEVEATRKTVRHLHETLGLVDSDSSATSGKGDPFIVRLGVDRQIEKQIEEENYLHRAFLNLEHSGRELESIVVGEIQKAYNAYASVLKREADETYDTVEKLRAGPISMPHDHEWNSFIANTDELVDPRVPLRDVENITYPGRDHPAAVEVRSGMLERKSKYLKSYTPGWYVLSPTHLHEFKSADRVEWQQPVMSLNLPEQKLGSHSQPDSTSHKFMLKGRQTGTMHRGHSWVFRAESHETMMAWYEDIESLISKTGEARNAYVRQHIRSASGMGWRNSSDGMDEDEADRTPYSAESAVLHQERPTSQPRQPGGRFPSDVQIDRHLEAPLSPSSGESSGERDLLAAAGSLPDGRNSFSNADVEMGENHAGPSAGTPVERRDSYYDSWMGTSDAATRQRQFAQQGQNPNDNREPAGSDRGSASNLYVAGIGATNSRDPSLTRQRNRGESTSTALTATNVTDYTHTTVPTSIDEREETSAQPDGFAVDGLGLSKQQTAASEGPSIQTAPNGPVTTDMAVSRNGSVKRPPAQTKGSVSTLELQIPGHYPPAGMATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBQ0</accession>
    <name>A0A317XBQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_620341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472767.1">
        <property type="nucleotide sequence ID" value="XM_025616925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBQ0"/>
    <dbReference type="STRING" id="1450535.A0A317XBQ0"/>
    <dbReference type="GeneID" id="37119068"/>
    <dbReference type="OrthoDB" id="4507328at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42656" checksum="FF3FE5E26BAFF611" modified="2018-10-10" version="1">MATKAPEWPILAASARKSEHPHERVFDLRHGANTLLRHLEVSKGSRVPNPIIDHVKNVQDFLIDLLKSPPGRFWSQGHEALQAEIKALRQSMEERLHSLEIASKDPSFPDDRSWANIAAQGGAPPVASTRSGSTGIPPSELMEAQIIVKLGDPDDVARFRKMIPGDMLAKAEKARIQVCQAEAPPAGRCKIRREAEAARQHSARARRLWKDADIRTPTWGMVVHGVRIKSVDLTRPEGIIKALLTDNAPSEEVFSMVVEFTSPVPANTAIKYSVLWISEILTAVKYDRSARLRQCYNCQQYGHIGSEGRDARGTKVCQLRGHTLRVEQEMPGTREESAVNRGQGRLEGPWPLPLCSSPFPSNVLVDEDGIHKRTDNNTGQRLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC18</accession>
    <name>A0A317XC18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_455350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472844.1">
        <property type="nucleotide sequence ID" value="XM_025607650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC18"/>
    <dbReference type="STRING" id="1450535.A0A317XC18"/>
    <dbReference type="GeneID" id="37109793"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF140">
        <property type="entry name" value="ATPASE, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY96083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="374" mass="42096" checksum="30B91A6C69FD802D" modified="2018-10-10" version="1">MSASMPLEGHSLAIFVVSVVMMCIATLAVALRIFVRVYLVRAFGWDDALMILALALFIFLDICCIIGSENGIGHKNDDFTDLQTYERALLWWWLGQMLYLWSSGVAKISIALALLRLTVRRLHRIILWAIIGVVIAIGLMFWFILLLDCRPISYFWLRVDPTHTGTCQPIRILLAIAYLYSGITIFCDLTLGILPMFLIWRLQMNNRTKIALGGVLSLGAVASVAVIIRLPFLHYYEDINFLYSTYQIAIWSIMETGLGITAGSLVTLRALFRWFLDSNPYHRRGGKPSGRQYPLSSLTGDASKKSSRDPSYWRPDLVPDKLNNLTVTTVSSPMARSPLSEANSSQEVLNPADEAWNARNQVSIHRTFQVSEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCK1</accession>
    <name>A0A317XCK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_484846</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471429.1">
        <property type="nucleotide sequence ID" value="XM_025608971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCK1"/>
    <dbReference type="STRING" id="1450535.A0A317XCK1"/>
    <dbReference type="GeneID" id="37111114"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="446" mass="50803" checksum="A1BC1AEBD1445B53" modified="2018-10-10" version="1">MVRRSDKGHMHREFIDLHTKYGKLVRVGPNEVSVADLDAILAIYGAGTKFRKSDWYSVWQGHRTFDLFAERNELIHGAQRRLVNNVYSMSSLKDFESGVDSVVEQFMQCMARQGPEVTVDIGKWMQLFAFDIIGEITFSKTFGFLENGTDSGAFQQIENALRSASWVGQVPWLYWLHDYLTPIIGSHLAITARHGTIRQIAAREMTSRKEGKQLVGEKRDLLDKLFDVQNKKDKQMSDNDVLSMAASNVFAGSDTTAISLRSIIYYLLKNPQCLSELREEIEDRKNQGRLSDPVKLEEANDMPYLQACMYEALRLHPAVGMNLPRVVPKEGIVIDGCFLPGGTIVGVNPWVVHRDPSIYGDDVEAFRPERWLAEKTGDMKRYFFAFGAGARLCIGKNISWMEMSKMIPTLLNRFDIQLADPDAVWKETCWWFVKQEGLVIKLCPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCQ5</accession>
    <name>A0A317XCQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_226111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472128.1">
        <property type="nucleotide sequence ID" value="XM_025606259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCQ5"/>
    <dbReference type="GeneID" id="37108402"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016468403" evidence="2">
        <location>
            <begin position="27"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="81" mass="9300" checksum="E5FDC35ED0A35A0F" modified="2018-10-10" version="1">MRPTSSYILGAIIIIVPVLYHQPAQSAGEKDFSAKKRKRKRERKWAPHSRRMLGVSNLEGWLVYPQDSHSTLVAWLQLQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDB7</accession>
    <name>A0A317XDB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_600298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472463.1">
        <property type="nucleotide sequence ID" value="XM_025616344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDB7"/>
    <dbReference type="STRING" id="1450535.A0A317XDB7"/>
    <dbReference type="GeneID" id="37118487"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="430"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="488" mass="53015" checksum="BE461AA12CAAEC2C" modified="2018-10-10" version="1">MTESYDPHERPGSPGLLPTRISYELKESPPPFDTGDQSPKGNAPKYDAEATCLPGSSHPNRPDLAAYADEHPFNAGIPVEDSFQELPKFKFNPDKSLPERVAIEALGLISPSEPKEEGEPSGAPKIAPAAPKESLRPSVAVGEPPLKEESQQQQNQQQQQQQQHTPPSLPPPRQERKLSDPESRLSKLLIINPSEAQLPALHSSATANSVDHSLPSLQTALAGVTDVPPPHGGPGRLNGSSYGALPSVSAASPPVSRTDPVWDHQRLGQFPPPSQVPPSPYSHLSPASSKDMSAMSSPASQQSYWRPPMKADITYLTSTYEAAPPTAKSPATSYPTPTDQTPASTCDRSYNPPTHVNGAVSAGAYKCRHPGCTAAPFQTQYLLNSHANVHSQDRPHFCPIDGCPRGPGGKGFKRKNEMIRHGLVHNSPGYVCPFCPDQQHKYPRPDNLQRHVRVHHVDKSRDDPALRQVLAQRPEGSTRGRRRRTNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDG1</accession>
    <name>A0A317XDG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_570687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473126.1">
        <property type="nucleotide sequence ID" value="XM_025614836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDG1"/>
    <dbReference type="GeneID" id="37116979"/>
    <dbReference type="OrthoDB" id="4506787at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="374" mass="41749" checksum="EE5F76A885B76D6D" modified="2018-10-10" version="1">MTNSNHNSHSILMRRVHKMKSLSSLFPCLQARKLRRQRRQDYHASWTCAGISELAQTSELSDAHEHEKHYEYDHAPQSEKLTALPDQPHEAATKTPQTTSSIRIVRPEESECSTLEFDDLPQDQEPSAKQTNTLSDEETDVECSPKLPQKVITMTVGPQTEETSTPRANVLPQSKDDIDLELSSRRIPRSPDKKPRPASMDVPPSAVTKLPEIKSRIIEDIPEDVEEEAKQNVNVAGSEEEQDLETTKPAKRSSAWRLSQRKSMVEIFNLLQSTAAAVASAPKRSNIKLPKSLRPSPAPEPSSPRPPTPPPKSPTLTTESDQPSTAAPTLTTPSSSPTKKQRRMGTAVFPLPHQWPETHEDITNIKTNNQTLFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDH9</accession>
    <name>A0A317XDH9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_561865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473146.1">
        <property type="nucleotide sequence ID" value="XM_025614247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDH9"/>
    <dbReference type="STRING" id="1450535.A0A317XDH9"/>
    <dbReference type="GeneID" id="37116390"/>
    <dbReference type="OrthoDB" id="10055769at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.790">
        <property type="entry name" value="RNA-dependent RNA polymerase, slab domain, helical subdomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="452"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY96385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1274" mass="144650" checksum="241B53C615AFD0A4" modified="2018-10-10" version="1">MVFPRTPVRSGPELSQLIDLINEQFDLDIPNPRLYSPSVGRNDKSLSWGIYRRIQRLYFDRSVDLNRILNNFEEWVLSQSTTQIVGGSRYGHIPGSFSGSFGRDSLTGHGGRRISQHERQERLTYLVGLIDDELYLLNKGSFSAFKGDDGLSAEHPAITGRSLKRRLSVEEEEEFHTAPNSPVKDPDRAGTPMDRGKVCNLDIGHAMDLQPTTIVPVHIFKSPKTTDMTKKPSRFVERLTASDSYPRYEAMPAAHNGANFSFSTTEASSAFLYSNNGRYDTSFTSTVTEATEPLLDSESMYEDSVVGHLLSQGTTTFEEQQAPNAFALQEPVYSDEGYIMEDLLHHGPFSLDHQYPSSVPFRYRYELERVARAWDISLDRMLVGSSISFKTLDDFWGWIGGHNQRQGKRLPEKPSRKAWEAATGSFKTDKHSEVVALTGDLDWCGESEKGIFKLRLNPLKTERTCRFHRRFGSDRFLSLTMPAPARPPPHPRLTSQPTLLRESLALWLTQNVHRCLGRVWKPFFVEEVESKRKIKSERRFRVDFFAIDGIDFDHGAHPVSSVAPPGQDSGSHTPMSLDALIDWHMPQEANRSQSNCKLFQRFSLGLSKTFATVILRPHQVLPLPDESNRPVMNDGCALMSRGLANQICDSLGLTGNTPSAFQGRIAGAKGLWMVDRHQSQISAGGEDIWIQISDSQLKIKPHPHVWQEPVDDEQLTFEVVKWSKPLHPVALNTQLLAILEHGGHVKEHIADLTRLGIRSVYQDFAEVLKSDSPVLCRSLVQKIRPSGDDGLGLMSQKAWRFEQWMSNDAEFIIRLTEAGFGPRSFYPLRKRLGKCLRELLNRYVDELHIEVPLSTYAFCIADPYSVLKPDEVHFGFSNNWRDGNGQFEDNLLDGVDVLVGRLPAHLPSDIQRRRAVWKPELRHFKDVIVFPSTGDIPLAHMLSGGDYDGDTPWVCWDQNIVHNFYNTDLPSHEFPPEHYGLTKHSVPMREIESMDEFLQSAFTFNLTLSNLGRCTVEHEKIAYDESIDSDKAKELACLLNHLVDGRKGGVHLSEQSWRQYRKRISPRNPTRRHKKTNIIDYLRFEIARDEQRKMLTKLEEAFPENEASPSKDEDLKVQLDRNGSGELYTAVQEMSKKIEGFYDRWSSSLQGGQNSFSPLTLEAADEARAIPPPSGNHPLIQVWQHSRDEWLRHPRFGFVIHAFGEVLCQIKTSTLPARTVTTEMLSYYPRDAMGEEEALDGEDEYEGHEAIEAMLFGMRPSGGYYDPDDCMSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDV7</accession>
    <name>A0A317XDV7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_18002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473480.1">
        <property type="nucleotide sequence ID" value="XM_025605970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDV7"/>
    <dbReference type="STRING" id="1450535.A0A317XDV7"/>
    <dbReference type="GeneID" id="37108113"/>
    <dbReference type="OrthoDB" id="193716at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17964">
        <property type="entry name" value="DEADc_MSS116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="45"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="262"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="489"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="535"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY96719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="552" mass="59002" checksum="DFE09A5E8B7024E0" modified="2018-10-10" version="1">MQGPGINDGAQPYATMAGKLDSKLLQALDVMGFTHMTPVQHRVLTVLPNWRSDCLVQAKTGTGKTLAFLLPALHCLLQGFSAPPRGQVAILIITPTRELAQQIAKSCDQLTSQLATRLRCDIAVGGTARASAFSRFMKEAPSVLVATPGRLKDYLSDPSAAEKMSNIQTLVLDEADTMLEAGFLADVKQILRLIPPKSTGWQGMCFSATVPPKVKDVVNVVLKPGYSSISTIEKNEAPTHERVPQYHVLMPSVAETFTTLASLIQLESKTSSKIIVFGVTANMVALFAAAFSRGLTPLSVFEIHSRLSQSARTKTTEQFKQAAAGILFASDVIGRGMDFPNVDLVIQVGLPSNGEQYVHRVGRTARAGNDGRAIILLTEAESFFLKANRHLPIQPHPQTDAINAGAASCAEAVTEAMYTIDEEKKQRAYSSFIGFFAGSGLMKQLRMDKPGLVQLANDLAINGMACPEPPPMDKKIIGKMGLKGVPGFNYATGSDSVRSSRPQGRTPGKPRDVLSPGGGERRGGVEKNRGGGRGGRGRGRGRGGRGGKPRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDW1</accession>
    <name>A0A317XDW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_529746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473122.1">
        <property type="nucleotide sequence ID" value="XM_025610516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDW1"/>
    <dbReference type="STRING" id="1450535.A0A317XDW1"/>
    <dbReference type="GeneID" id="37112659"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000354">
        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="262"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="749"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="913" mass="98867" checksum="AAFDD12AC0E1E6EB" modified="2018-10-10" version="1">MDDLNGLSWTPSSSNDAHKPPPMNTGLLFPSVRRNDTSGRSTPLSASSGPSNAPSKSATPDKDSFANLVSFNSANANKNLSLVEQQKRLEEERARKEAENRSRFETQYGGQNTQFWDSLEKGRGNGFPTSGTPAQRSAPLPEEDDLLAAFNASAPVDASTNFPVPSPSPSPQHLSSSQAAPNNADMSRPTNTMSFPDDDDPFGLSQLKPKPAQPPQPAPADDDDFLGLLGKPVSEVPRSEPPVKAPSPIESEYHAPSPKPLNGMDRAVAELVDMGFPADKASQALRMTSSGTDVQAAVGLLLTQAHEEARQKSKNRPTPDERYTEQPSRSRERSERPGRDVPSWMQQERSRSNNRTGSPADKDPSQLAATFGNNLLKTANSLWKTGSKKVQQVVQDLNADHDPSQPRWLRETSSHDESSSSDRPRVASRPKARPEMMTDEALLLESGGPPRQSRNAMRSEDALPRRPSRNALRSDDVLASRPSSNGARHQPSPASERRIQQPAFMQQHPRAETRDPRSRLTKTALEEQSAQAYVSPARRKRPVAPSPALEPTVDLFESPAPAPAPVQRPKPSPAPAQASRSSTPSTTLPARPKAPPRAVPPVSPDALSTTHRQRGTAAEAYKRGDYAAAHEAFTAALTPLPNKHPITIIIRSNRAMTALKVGEPKVAISDADTIVELIGPSKGEGESIDLLNGEPSKPMKDFFGKALMRKAEALEQLERWADAAQAWKLAVENGHGGSTSIQGRNRCEKAAGISKPASKPAAPARRPPPPAPKKVSALDDLQGRSASSGSSFEAVTRLRAANQAAERADEEKFALSESVDARLAAWKNGKQDNLRALLGSLDTVLWPEAGWKKVNMSELIMPNKVKIQYMKGISKVHPDKIPTNATTEQRMIAGAVFGALNEAWDKFKKENNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEZ1</accession>
    <name>A0A317XEZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U1 small nuclear ribonucleoprotein C</fullName>
            <shortName evidence="9">U1 snRNP C</shortName>
            <shortName evidence="9">U1-C</shortName>
            <shortName evidence="9">U1C</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_581559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the U1 small nuclear ribonucleoprotein C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471981.1">
        <property type="nucleotide sequence ID" value="XM_025615414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEZ1"/>
    <dbReference type="STRING" id="1450535.A0A317XEZ1"/>
    <dbReference type="GeneID" id="37117557"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000243">
        <property type="term" value="C:commitment complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000059">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03153">
        <property type="entry name" value="U1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY95220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="194" mass="20398" checksum="36947E575848136F" modified="2018-10-10" version="1">MYTVTLQLTNGLTIGDYCDVYLTHDSMSVRKAHNSGRNHLRNVLEYYQQIGQEKAQSVIDSITSSYAAEGQAVPNPAMAPPGAYPPPFGFPVRPGQLPPPPFGMPLPGGPGGAPGMPPPPGARGLPFPPPFPTAGGAPPAGLPPLPNMPPVLRVSLPHPAVSRTSKHPLALPVSRRFLPRARAQLDTAPALHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFA0</accession>
    <name>A0A317XFA0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_561942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473253.1">
        <property type="nucleotide sequence ID" value="XM_025614254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFA0"/>
    <dbReference type="STRING" id="1450535.A0A317XFA0"/>
    <dbReference type="GeneID" id="37116397"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF282">
        <property type="entry name" value="WW DOMAIN-CONTAINING OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="280" mass="30537" checksum="C12D0518A347A9CE" modified="2018-10-10" version="1">MAITAESFMPDLSGQVALVTGFGTSIELARKGARVYIAGRSESKYQDTVQTIIAEYPAADVRFLPVDLMDLGSVSRAAEIVMQQESRLHLLVNNAGVMCTPYEETKDGFEMHIAFADDSVAGTVRIVNVSSDGHEKLAPKRGIIFEDANLKGDYSVWTRYGHSKLANVLYTKELAKRYPNILSFSVHPGTVKTNLSQGPLASIPLYHFVKPLVELGAPGPRKGAANILYAAVSGSLSSSDNGSYFLPVGKMINASRSGEDLQMAHKLWGWTEEEMRSRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFL8</accession>
    <name>A0A317XFL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="14">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_562048</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="14"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473403.1">
        <property type="nucleotide sequence ID" value="XM_025614263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFL8"/>
    <dbReference type="STRING" id="1450535.A0A317XFL8"/>
    <dbReference type="GeneID" id="37116406"/>
    <dbReference type="OrthoDB" id="3227768at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <keyword evidence="9 13 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 14" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016195315" description="Extracellular metalloproteinase" evidence="14">
        <location>
            <begin position="29"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="15">
        <location>
            <begin position="81"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY96642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="636" mass="70022" checksum="4CBC59247D6B0D98" modified="2018-10-10" version="1">MYGIQMIGGISVLPLLAAGLPTAQVAHADKVAVDLNAFRFVSNTDYVNSLAVTTENLTVAAYEGDYTETAARLVQEIAPGATFRLVDDHYIGDNGIAHVYFRQTVHDIDIDNADFNVNIGKDGKVFSFGNSFFTGVLPQTNPLGDHKFSAPVAALRGAKDALRLPVAISNVSTEATDEQNSYVFRDTSGAVSDPMAKLVYFVKPDGSLALTWRIETDVDEHWFLTYIDAETTSEVHGVIDYVAEATYQLTRHIPWGVTDPTDGNRTIITDPWDLATSQFTWIGDGWRQYTTTKGNNAIAQWNPSGGSSYLFNYRPSDAKLNFQWPYSINMTQPSSYINASIVQLFYTVNTYHDLLYTLGFTETAGNFEYNNGNHGGRGRDYVILNAQDGSGVNNANFATPPDGIPGRMRMYIWTEANWPRDGSFEAAIVIHEYTHGLSTRLTGGPYNSGCLNSMESGGMGEGWGDFMGLAIRLKPDDTRETSYTVGAWSANDDDGVRLYPYSTSLTENPLTYSTVNYLDGVHDIGTVWATMLYEVMWNLIDKHGKNDGPKPELRNGVPTDGKYLSMKLVMDGMALQPCNPNFIQARDAILDADVALTGGKNKCEIWTGFAKRRLGFGAVYHRSRRIGSTDIPVGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XHH3</accession>
    <name>A0A317XHH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine pyrophosphokinase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_16587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473381.1">
        <property type="nucleotide sequence ID" value="XM_025605904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XHH3"/>
    <dbReference type="STRING" id="1450535.A0A317XHH3"/>
    <dbReference type="GeneID" id="37108047"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="137"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="322" mass="36014" checksum="10B2C129EA26CFB5" modified="2018-10-10" version="1">MGKSYLDLVNECDRFPYYEDNPAVYLEHLKNYHIFKVAGCDAALGYILNSTVEKFFSLSDCWSIDTANRTVTLVAPADATPEQRSQLVAKSLDKAVELGTFDILKGWRNEMYPVYGPGGEFLLEMERSATPLFGVVSYGVHSTCYVDDADGLRIWVPRRSRTKQTYPGMLDNSVAGGMSTTEHPFECLVREAMEEASLPEDVVRANATAAGCVTYTYVRSSKAGGETDMVQPEVEYVFDIKVGADIVPKPCDTEVEEFNLYTVEETKAAMANGEFKPNCAVVLIDFFIRHGIITPENEPDYLEIVARVHRRFEFPTASHVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317US39</accession>
    <name>A0A317US39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_629334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000066">
        <property type="protein sequence ID" value="PWY64784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461330.1">
        <property type="nucleotide sequence ID" value="XM_025617552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317US39"/>
    <dbReference type="STRING" id="1450535.A0A317US39"/>
    <dbReference type="GeneID" id="37119695"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY64784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26991" checksum="60C121F35E69B831" modified="2018-10-10" version="1">MRRQGKYIDEVSQDDNDDKDAATPISEPESSATQTEYTSLGGLSSPAAGASADWADIIIHNEDVATLRRYVDSNKNGFPIAYERSYCHLFDIAAEYGRLRSLRVMVEIYVADPTMDEPVDKCLARIQCSLMDVACRYADREMVLWLLHHDPPLGTLNGEDEMTGGLVSTEKPCPEVVKNAREDMIKILRDAGASMDQPNAAGRTPPQVLEDVEEKRRRREQEEASRRAAGFRGRGLGREGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UX68</accession>
    <name>A0A317UX68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_551569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461601.1">
        <property type="nucleotide sequence ID" value="XM_025613547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UX68"/>
    <dbReference type="STRING" id="1450535.A0A317UX68"/>
    <dbReference type="GeneID" id="37115690"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY66146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="224" mass="24664" checksum="07B3F133A03DA960" modified="2018-10-10" version="1">MVGAFLDKTGHRHSLASSMFRDAFVAVATVVFAYAGHVAFFTLFPEFRDVKAYPKALVLLQLSKIMLYRATAIVIYKLFGPDVTISLLSWAIVQDDLAWECNSNSERTVITLLSQLVKHTSKSVIAGVVNTHVAAKRHALTFIQGNVPICAINWLGAWILVESIPVFNDVSGFASPRLSLPGIILTGHVLPITGQAKKRNDEQINSKACVVCYDLLFFLTLLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYW4</accession>
    <name>A0A317UYW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H2 subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461908.1">
        <property type="nucleotide sequence ID" value="XM_025612923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYW4"/>
    <dbReference type="STRING" id="1450535.A0A317UYW4"/>
    <dbReference type="GeneID" id="37115066"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204">
        <property type="entry name" value="OS02G0168900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47204:SF1">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="160" mass="18104" checksum="6ACA7B7B49134ADE" modified="2018-10-10" version="1">MFAIQPAQKSSSNNETSTDHFTPNILPCRIHHDGPVESLNRYWTPLPDEKDNNQQTAYFRGRRLRGRRVAIPEGYEGVIATPTDRVMPATPPSTDVEVEEVIPEEPVKILEKQGTFDEYVVWGHEWVPAAEDSFVKGVEEWIKLAEAMHTTPSSEKKSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZ25</accession>
    <name>A0A317UZ25_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chalcone isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_540871</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000060">
        <property type="protein sequence ID" value="PWY65250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461375.1">
        <property type="nucleotide sequence ID" value="XM_025613009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZ25"/>
    <dbReference type="STRING" id="1450535.A0A317UZ25"/>
    <dbReference type="GeneID" id="37115152"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chalcone isomerase" evidence="2">
        <location>
            <begin position="125"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY65250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="369" mass="39420" checksum="BDDCB592D0026BF9" modified="2018-10-10" version="1">MVLCAVGMYAVIKSDVFGLESTASSNSNSKESEEKATTDGETNSNGAMKLDGPGGLFPSNPALTIIHGEGEGEGEGKGEVETGTSSIPYFPSVIRLPTWIEGEQTPVKSGEEFKSGEKGVEKEEEEYHLLGLGIRTVSFLNIQVYVVGMYVAKSDLAELQSRLVKTAVHPPHVDEGGEKVIANEVGAAAATSLVSMERDKLRELLLDQAERGDEAWEGIVRENGLRTAFRIVPTRNTDFLHLRDGWVRGITGRAKKYNAIAAGGAGGEFEGEAFGEAMGVFKGLFSGAGQKNVPKGQTLVLARGSKGQLDVLAWGDKGVGRYMGRVSDERISRLVWLNYLAGKNVSSEGARRSVVDGIMAVVERPVGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V399</accession>
    <name>A0A317V399_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_310118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461926.1">
        <property type="nucleotide sequence ID" value="XM_025606818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V399"/>
    <dbReference type="GeneID" id="37108961"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="138" mass="14982" checksum="1D91755AB2C112AD" modified="2018-10-10" version="1">MASRSYGMRPLPGRFVACSVRRSAGGFPGLNCFPDGDDEGERKLIFLLGGASSTKFSVRLQPRSSWSPSFDPSGTDDFRAPAPPNTWGELPQTQASLSGLAANAIPSWIQNQTEAPTGPLVPWWYRGQGAREYCCRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6A7</accession>
    <name>A0A317V6A7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_539926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462551.1">
        <property type="nucleotide sequence ID" value="XM_025612803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6A7"/>
    <dbReference type="STRING" id="1450535.A0A317V6A7"/>
    <dbReference type="GeneID" id="37114946"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="46"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY69853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="276" mass="30360" checksum="1C2D14BD5DA31C0F" modified="2018-10-10" version="1">MSTPIRPSSPSRTSVLLSNLASVTSRVNAAAAKRTTTTTTDPSIPPRLIAVSKLKPASDILSLHQHPTTHHHFGENYLQELTEKSRLLPPTIKWHFIGGLQSNKCVTLARDVRGLWAVESVDSQKKASLLDKGWGERSEEVRATNHEDRLRIFVQVNTSGEENKSGVEPGSDAVDLCRFIRDKCPRLRLQGVMTIGAIARSKATTPENENEDFVCLRDTRDRVVAELGLVGEDARLELSMGMSEDFEGAIALGSDEVRVGTTIFGERPPRDQAKVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7K7</accession>
    <name>A0A317V7K7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_430122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462634.1">
        <property type="nucleotide sequence ID" value="XM_025607473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7K7"/>
    <dbReference type="STRING" id="1450535.A0A317V7K7"/>
    <dbReference type="GeneID" id="37109616"/>
    <dbReference type="OrthoDB" id="4526936at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016259776" description="Cell wall protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="45142" checksum="EE974C87D8505510" modified="2018-10-10" version="1" fragment="single">MRSDKLLVLAGLASYALALPTKDLDARTFGLVAEILTDIGEDLTGFIEALLGGGVKSSASLLTGISAQAAAVLEGGALGCTAGTIEASARAELAAWIRAHAEFDASLKTSLLAWCEGSASATLSVDVRAGLALFIPTCAEVAAKGDLYVTVDGIFSVTDLEAAVVLSSSLQTSLSAFVSGSVGVELDVDVRAGLSLCAGGGVVADLAADVEAALKAWLSGSECSLSASLKVAVEAWLEGKTATGVVTIGTVPTAGLTTVSVGAAISALVETSGTLTASAQAYLSAFLKSSLAADIESDVEVVLEACIAGKLASSVSADARVALATWLSGSSCSLGVELKAVLYFWLSFALSGDVTIDLSTDIITELETFITGTIDTLIGVNISGILSLLLSGESLASISLDSRAELSAVIGGAAGVDISSSIEVIIIEWLTGCSLSGGPTVSIGSGSGSGKGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V826</accession>
    <name>A0A317V826_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_540024</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462373.1">
        <property type="nucleotide sequence ID" value="XM_025612826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V826"/>
    <dbReference type="STRING" id="1450535.A0A317V826"/>
    <dbReference type="GeneID" id="37114969"/>
    <dbReference type="OrthoDB" id="5587616at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="5">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="405"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="299"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY69168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="449" mass="48965" checksum="26B8D034308A0A1E" modified="2018-10-10" version="1">MEPSAPPEDSSAKSQASLDELIKQAAAKDAIKDFNAAAELYSEATELQASLNGELALDNADLLFAYGKALYNVAVSKSDVLGSKVAGEPQAQPNSAPVGRPSAGSASTTAFVQKANAQGVPKNISEAQDTKSEDVPTKPYFQFTGDENFDDSDSQDDGDSEEATADDEDDFANAFEVLDLARILYHKRLDTIEGESGKGKSTDLSSDLKHVKERLADTYDLQAEISLEAERFLDAVIDLRTALDLRQSLFPMEDPSVAECHYKLSLALEFGSVNNGNDDSQEDSGNPGQVDEEMRKEAATQMEKAIESCRLRMNQEQKKLDCNYTLDEDKVTAMKRRIANVKEIIADMEQRLTDLRRPPVSITENGDTNDTMLKGILGQIVGQSASEQKARLDAVTREANDLSAFVKRKPSANKPNQKSEALAKRPAQEEAEGSDAKKPRVNDTDDGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9I8</accession>
    <name>A0A317V9I8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_539599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462818.1">
        <property type="nucleotide sequence ID" value="XM_025612733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9I8"/>
    <dbReference type="STRING" id="1450535.A0A317V9I8"/>
    <dbReference type="GeneID" id="37114876"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY71063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="289" mass="32458" checksum="9FF3FE36563C48D6" modified="2018-10-10" version="1">MTDLSKVIFTDSLPEHDKLVVPIDQIKSTINLAPNGLGGNMILQISETTVLKVGWRVNMAEAEALILLAAKTNVPVPKVLSAYMIGDVGFIFMSKIEGEMLATCLETMSREELQAIARQLESYILEWRKLGSSFLGTVTGGPCQEILFRHPWDYKSTKQYGPFHSFTQYKHAVVEALRLSRPVGVWYEKEQKLKEKILSFGDERTPNLGVMTHGDLHPGNILIKDGVVSGVVDWGEAGYSLPEREFFAANRIAMDPPWIEMVHACIPSFPKENELWDGVDRSMMRYSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFU2</accession>
    <name>A0A317VFU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_539380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463008.1">
        <property type="nucleotide sequence ID" value="XM_025612696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFU2"/>
    <dbReference type="GeneID" id="37114839"/>
    <dbReference type="OrthoDB" id="2740448at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="299"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY71772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="427" mass="45055" checksum="FAB99489F89F37CC" modified="2018-10-10" version="1">MSDAAPRKAKQPKLRASCDACGAAKLKCDRGHPECSRCLSNGLTCHYGLSRKMGKPPRDRLHRQSISQSRTAMDGGLDKLGHHDSHDQSLIDAELFPSVHEVPAWDGTISGHPPGGLLADLDALGHLGAPPLPFLSLEFGDELIADNSKHSMLASQMDFPSISAPDSPPMDRIGSTPTEPSARARALGGLKDHDCPREAYSILGSLSSLPLSRALGRPAGNSDPGVALDHLLRVNRGASERLTPLLACSCTRFPALALLYASILSWILIWYQEAAGCVTSGSPGLPCIPLDGAISPASSTGVGHGASGWSSTTGSGPGEREAPGPSTPTLVAGGMVPVRMAIGSFNIDDLRVQSALRTQLVLGEMGRVRRLIDAFSTCQDAGPRLGDGWKRGGVEGLHQSLASWLREEHARIANALRAQLKELNTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VG86</accession>
    <name>A0A317VG86_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_628258</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462754.1">
        <property type="nucleotide sequence ID" value="XM_025617471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VG86"/>
    <dbReference type="STRING" id="1450535.A0A317VG86"/>
    <dbReference type="GeneID" id="37119614"/>
    <dbReference type="OrthoDB" id="5319341at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY70860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="647" mass="72776" checksum="92AD3CA3FD07A8DC" modified="2018-10-10" version="1">MADVTQGTSRGVRKPRKSRGRGLRATTGCLICKRRHVKCDEARPQCGPCAKGHRDCVYGSDDYSTPSAGGVGTPVAAHSSPFPQLTSQVQLHEPLRVLIDACQHEHAASDRQPASVTASPGVRHSQTLTPDIGVNHNHRVSSTTPANDFAPSPATDSSVSTRLAPLSWFELLANDAVNADRNFLLSPLQRDPNPACQTPNPHLSNSNLQPHSIREHQSFQAAAFERDPDIENRIPQTSDGQPKLLPDHPSSWCTPAPIQLTDQEYQIFNHFVKNMSSWYDFFDPTRQISTKIPQLALRNIGVMKALLAMSARHLSIWHANKAQGRGAGVVRHRDDGRKVAEFPDVDRNSAVQYYYETLHYLNKAMQYPSYASSHEIISTALLISTYEMVDGSNRDWERHLKGVFWIQRYQNNDGECGGLRQAIWWAWLRQDVWVAMRERRRVFSFWRPKRHISTLEPTELAGFASYLLAQCVNYASREEAASKDIQSRLERGNELLYMLQEWQDYLPPEFSPLPTPQHTDVFPPIWVHPASYAAALQIHSLARILVISHRPSVGGFQDYRAAQKLLTTSVNTICGIARTVSEDDLAASLMCLYCVFGAGMSVHTPHERAALLDLIGVFERRVCWPRYSLRNDLELKYQKDGLSVFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIU6</accession>
    <name>A0A317VIU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_539000</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463382.1">
        <property type="nucleotide sequence ID" value="XM_025612605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIU6"/>
    <dbReference type="STRING" id="1450535.A0A317VIU6"/>
    <dbReference type="GeneID" id="37114748"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF34">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE SED4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016264119" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="21"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="198"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="559"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="561"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY73117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="581" mass="61896" checksum="54CD2C17C5B98857" modified="2018-10-10" version="1">MVAFSRISAGLVALAVPALGRVVLESVKSVPSDWTLVEAADSSATITLSVALARQNLDQLEAKLLAVSTPGKATYGQWLDLDDINEQFPLAEDTAVVSWLKEAGVTKISREGGLLNFATTVGTANQLLNTTFSVYRSGSTQKVRTTQYSVPDSLTGAIDLISPTVFFGKSNAARSAAVRASQIIKDSTSSSSDDVCEYITPACLKEQYSIDYTPEASSGSRVGFGSFLNESALYSDLDLFTQYFDITEQSFTVVTINGGINNQEDDPDGEADLDVENIVGISHPLPVTEFITGGSPPYIPDVEETSDENEPYLQYYEFLLNKTNAELPLVISNSYGDDEDTVPIAYATRVCNLIGLMGARGISILESSGDSGVGGACMSNDGTDKTEFTPMFPGTCPYITAVGGTQDVPEVAWVDSSGGFSNYFSQPSYQSSQVSTYLDNYISDSTKEYYEQYTNFSGRGFPDVSAFAGSPYYESVIDGQLTLVAGTSGASPVFAGVVALLNDARLRANKTSLGFLNPWLYSTGYKSLNDITEGEAVGCEGDTEGAGVIPWASWNATVGWDPATGLGTPNFAKLKEAVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIW6</accession>
    <name>A0A317VIW6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_238337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463637.1">
        <property type="nucleotide sequence ID" value="XM_025606349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIW6"/>
    <dbReference type="STRING" id="1450535.A0A317VIW6"/>
    <dbReference type="GeneID" id="37108492"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="211"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY73885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="524" mass="59181" checksum="B50741C9DE46312D" modified="2018-10-10" version="1">MQVPTVIDRTRHRDRTILTQSRELDLRAISMSGNALGTLCTFNGLPFFSPTGQQWIKSRTGEDVNLAHMSPKPSTSNQVTSTGVPHSVALPEKEVVIQLLDEWGPSILSRLFPFINRELLEFTIKAAYHDEVSVSSPGADSARACIHAFTAVCLSSSIYRGHEVMHAEDHVHAAYKLLPGLLIELVTLDGLQTVLMLCLCSLVVTGNIFYLEMLLATSSRFVFHLNGHLAPVYINDDLQFKTKLHTRTLFWICYITDKEFSLRTGHPPCLDETHCDLTLPDIQQTTQEFLTCIRLAILLSQVYHGLYSMKALHGTDNQLLGTIRDLDNALETWRMSIPARNRPRLIDRETDVISTPNTLIQLQYLYCMAMIHHASGKCSVWVQNHDTSEAGSSLAISVEASRSMLQKFLDDCFHFDKNNLRYAHVVFSSTFQTAKLRRRFCLPYFLTAICHLFSNILLNPLDEGSDDDLDLIRSVPTHIRDRLPPEIPRLSSHQVKLFEDFVMELGRLASSAVNKAQELFEANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJX0</accession>
    <name>A0A317VJX0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_252336</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463153.1">
        <property type="nucleotide sequence ID" value="XM_025606442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJX0"/>
    <dbReference type="STRING" id="1450535.A0A317VJX0"/>
    <dbReference type="GeneID" id="37108585"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="322"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="507"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="574"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY72200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="793" mass="87327" checksum="28B1855458AC777E" modified="2018-10-10" version="1">MLHEILLSLSGQPSPLFNSQSEADVVIEDAFPLVSPPEKALLASLARLSRLHAELRAHTALISSSHPSVICRAVSTAIGSRHLGEFQRKILEVEKAILVEDSGYVGGYGIVPLSTIVGEFSPWTRRLEWLWETVRLIWPIDTRDQDQLCTGVALIDHLRTESQTGYVDLKEMALHLVGIAETAWMRQLSTWLLYGNLPVLGESDFFIQRDNTSEGDQPFPTTQFVVHPELLPQYVTTHTASSILFIGKTLNLIRAKRSAPTVNPSAIVSTTPVTLHTEHIEHLASLKSPISAPRLSSAVNAIRYSLSQSTLSKLFPLQKILEILSVLHDFLLLRRGEFATALVSHADARIQDRYRKHVHSVSKYNPAEGLGGLSIKEGDVVTTLSQTLSELYSLQTEEDPADDELDLAKDLLRLSIKQAMDGKTMLSPDMVEVEMGTGISDVAFDDLLFPTPTYLSAQVRPPLDLFLSASDISIYSKIHSYILGIRRAQIHLGDLWKHTFLRKVHPSPWGPPRSSTPYGQSRLKLGRQRDSTRTRQMRPIWATSSASLFVLSEIGSYFQGEVLNGSWHHFREWIEGGPPKTGSRPGTASSSKGKHPQGLDIPTDSGFGDASQAIQRHDPETLTAAHRRYLFALTESLFLTDIPFTKALRALLTSVEHFIALVVRLKGIQRNMDLETDEGVIDALVDYAAEEREVWQSLGAARASVEAGIKDAVARLRDIDDSRSGEGRQMLDFGKDSRENGQFLSANGSATGPGLCHYVPRKAAGVDHLLMKLDFGNANGGMVAAPGTFGGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJZ7</accession>
    <name>A0A317VJZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM8</name>
        <name evidence="12" type="ORF">BO94DRAFT_475194</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJZ7"/>
    <dbReference type="STRING" id="1450535.A0A317VJZ7"/>
    <dbReference type="OrthoDB" id="422364at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY73192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="98" mass="10862" checksum="F0E0761AC145D254" modified="2018-10-10" version="1">MSLHSYINKKVCILTVDGRTLLGTLLSTDQLTNLVLLDTIERIIRTPDDPEPSSQIEHGLYLIRGDNVVLCGEVDEGIDNDIDWTKVRGEVVKGTKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VK21</accession>
    <name>A0A317VK21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_538864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463571.1">
        <property type="nucleotide sequence ID" value="XM_025612576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VK21"/>
    <dbReference type="STRING" id="1450535.A0A317VK21"/>
    <dbReference type="GeneID" id="37114719"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY73819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="302" mass="32798" checksum="8FDD63D20D7C2810" modified="2018-10-10" version="1">MPPKPRPPPSRAVTVSKALSLLLRHAAEKEGLKIDAQGYANVADVLSWRKLKSLKVTFPEIIEAVANSDKKRFALLYAPASTPTETEEKEAAESKEESTTAAITASTTDSTPTHYLIRATQGHSIKSVEAAHLLEKLTLEGKDKLPGTVVHGTYHSAWPAIVASGGLRCMGRNQVHFATGPGVEEVLGQLDQNKEGNGDKGKVISGMRRDAQVLVYVDLERALKAGCPFWRSENGVILSEGMSVGVAGEGEGGEKMVPLEFVDVVVERKMGKIWERGQVVQQWPSEWAQGRNPKGRSDGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VME3</accession>
    <name>A0A317VME3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_627593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463335.1">
        <property type="nucleotide sequence ID" value="XM_025617436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VME3"/>
    <dbReference type="STRING" id="1450535.A0A317VME3"/>
    <dbReference type="GeneID" id="37119579"/>
    <dbReference type="OrthoDB" id="4526774at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="54"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY73070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="330" mass="36375" checksum="E9F3F3F8C78FAD12" modified="2018-10-10" version="1">MPGQAIPLLTIQSTAGTSHVAEIIESQIHVERSTANFFSIYRYANASQLCMLCVSGCCAVAAGAAMPLVTVVFGALADEFINGEHHTSQEIRDQVQHLTLFLVYIAIGSLVTTAISTLGFNFIGEQIARHLQQKYLSSVLQQNMAYFDVVGTGELTSHIDQDMKWIQAGISQKMGDLLSGLSGFVVAIICAFVRNWRFAGIMLSQPITLILLVGLMGYWLSVVQQMGLAERVQADNLAQEVFSAMRSVISYRSQERYAKKYRKALGRPAALDFRERLIFGVIVAGSFMTLHWGNGLGFWQADHLVRQGRCTISEALTILLMRQPVAFSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VS33</accession>
    <name>A0A317VS33_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26S protease regulatory subunit S10B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_538258</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464202.1">
        <property type="nucleotide sequence ID" value="XM_025612455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VS33"/>
    <dbReference type="STRING" id="1450535.A0A317VS33"/>
    <dbReference type="GeneID" id="37114598"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="170"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY76389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="393" mass="44171" checksum="810487CD302E3E34" modified="2018-10-10" version="1">MNGASDPEREQALEDYKRSLLELREWESKLKSLRMGIKDLQREFDISEENIKALQSVGQIIGEVLKQLDEERFIVKASSGPRYVVGCRSKVDKSKLKQGTRVALDMTTLTIMRMLPREVDPLVYNMSLEDPGQVNFAGIGGLNEQIRELREVIELPLKNPELFQRVGIKPPKGVLLYGPPGTGKTLLARAVASSMETNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIPLPNEVGRLEILKIHSSTVQLDGEIDFESVVKMSDGLNGADLRNVVTEAGLFAIKDYRDAVNQDDFNRAVRKVAEAKKLEGKLEYTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSV5</accession>
    <name>A0A317VSV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_588964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464104.1">
        <property type="nucleotide sequence ID" value="XM_025615918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSV5"/>
    <dbReference type="GeneID" id="37118061"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY76107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="187" mass="19908" checksum="510A4F6D389CB1CF" modified="2018-10-10" version="1">MGVQSQTAESALLYNPTSLPFRVKSPRCCIGLFGPQSAQEVSLAAMGLLQMKTRDNRCSSGMHRRNDTSIPLVGARKGLPISTSNSSLQHLSALSTHLHSPVPPPPRPLSAYRGRALVPLKAKLIDPEPTFLLAPADESTAPPLQPSTVSVVGVGLLQAQEEASQSPSSGLAHWRTHYASDSTWSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VT46</accession>
    <name>A0A317VT46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_208972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464109.1">
        <property type="nucleotide sequence ID" value="XM_025606140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VT46"/>
    <dbReference type="STRING" id="1450535.A0A317VT46"/>
    <dbReference type="GeneID" id="37108283"/>
    <dbReference type="OrthoDB" id="47488at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04486">
        <property type="entry name" value="YhcR_OBF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834">
        <property type="entry name" value="ENDONUCLEASE/EXONUCLEASE/PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42834:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016305462" evidence="1">
        <location>
            <begin position="20"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="301"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY76112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="603" mass="64510" checksum="572799BC67C3664A" modified="2018-10-10" version="1">MRAFPSLYAAALLLQTALAATIREINGNKYISSYKGETVSGVKGLVTAKGSSGFYLRSTTTYTNGRSYSVYIYSSDGVSQVEVGDIVSLSGTVAEYRSSSSYVYMTEIESPSDITVISSGNDVDPTVIGQNDLDPPTEQFSSLDNGDVFSLPGGSSLLSTANPVLKPTKYGMDFWQSLSGELATLTGLTAVSKASKYGDTWVTGDWPVTGKNDRGGLTMSANDSNPEAIVIGSPLDGSDNPTDIKMGDSLEDITGIITQAYGFYTLLPLTALKKTGSKSTQAAATTLSSDGTCSAITIADYNVDNFSPDNSRMSGVADHIANYLNSPTIVFLQEIQDNSGSTDDGVVSASETLSNLASAIKEQGGVEYNYTDIDPINDTNGGERGGNIRVAYLYDPSVVRLRNYNPGSSTDATKVLAGGGLSYNPGLIDPSNQAWNDSRKPLAAEWETLDGKNSFYTINVHFTSKYDSTSLEGDARPPVNGWVENRVEQAKVVANFVTSILAEDSDAKILTAGDFNEYAFVEPLEVFVSESTLHDLEEVTGIPTTERYTYLYNQNCGALDHMFVSSALTSGAKMEHIHVNTWVSTADEKSDHDPTVALFNVCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTX2</accession>
    <name>A0A317VTX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_549189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464215.1">
        <property type="nucleotide sequence ID" value="XM_025613433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTX2"/>
    <dbReference type="GeneID" id="37115576"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14721" checksum="2CEA8DE34E24915F" modified="2018-10-10" version="1">MANAHALPPVTPLELHGRGLLLTRQSPARRGRADEEKDEKEPGASGESTVFGTDNGKQHDRDKYKSNRTHGYIRMIPCKSVWKRPDREKIEKKRREKGGKETATGRYRMNSLTDGLIGPAHAFHKGAYSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUN6</accession>
    <name>A0A317VUN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_568080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464616.1">
        <property type="nucleotide sequence ID" value="XM_025614661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUN6"/>
    <dbReference type="GeneID" id="37116804"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3620.10">
        <property type="entry name" value="YdcF like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051599">
        <property type="entry name" value="Cell_Envelope_Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336:SF20">
        <property type="entry name" value="DUF218 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30336">
        <property type="entry name" value="INNER MEMBRANE PROTEIN, PROBABLE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="268" mass="29417" checksum="69858B9CEDE9E845" modified="2018-10-10" version="1">MTMSSLNPKDVNRIAEFLAHEQIPATQPPANSDCIVVCVSAVLEPAETVFRHLQRNPHPTKTLVLCGGIGHSTPHLYEAVSKHPKYAHLTSEIQGKAEAYVLYTIFNTCFDAASIQKSGCKVLIEDKSTNCGQNASETRALLERNGIPEPISMIIVQDPTMARRTVASFDKAYGPAAPKLHSWPIIIPRVKLQGTELMYDVQGVTADGLWSMPRFLGLLMGEIPRLRDDENGYGPNGKGFIGHVDIPEEVERAFQALERGLGTESAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VV22</accession>
    <name>A0A317VV22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_538075</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464398.1">
        <property type="nucleotide sequence ID" value="XM_025612415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VV22"/>
    <dbReference type="STRING" id="1450535.A0A317VV22"/>
    <dbReference type="GeneID" id="37114558"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004762">
        <property type="entry name" value="Amino_acid_permease_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00913">
        <property type="entry name" value="2A0310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="10">
        <location>
            <begin position="83"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY77211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="586" mass="63746" checksum="4559DA8572BB8A60" modified="2018-10-10" version="1">MEKEFIEPKSEPSSSGDAPPLYGESETTKGSFGQRVWDSFKRDPNARATTHHEPGHDGRAFDIENAAQNTAESPLQRKLKGRHLQMIAIGGSIGTGLFVGSGTVLAAGGPASVLIAYALIGCMLYCTMHALGEMAVLFPVAGSFSHYSTRFIDPAWGFAMGWNYCLQWLVTLPTEIVAASLTVNYWNQSISNAAWVAIFWTLIVTINMFGVKGYGEAEFVFSIVKVTAVVGFIILGIILTCGGGPSGGYIGGRYWHHPGAFHHGFKGLCSVFVNAAFAFAGTELVGLAAAETANPRKMLPTAVKQVFWRITLFYIVSLTLVGLLVPYNDPRLLDGTSSADAKASPFVISIVNAGISGLPSVMNVVIMIAVLSVGNASIYGSSRTLAAMAEQQQAPKFLAYIDRKGRPLPALVVASVFGLLGFLAASDKESEAFTWMMAISGLSSIFTWGSICLCHIRFRRAWKLQGHSLNELAFQSQPGIIGSWVGLIFNCLVLIAQFWVGFAPSGYGTMSAASLVSNFFSDYLAAPVVLAFYIPYKLWYKTPFIRAKDMDLQTGRRELDIQALIEQEKAEQAEWPMWKKAWKFFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXN5</accession>
    <name>A0A317VXN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF52 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_182146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MEMO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464864.1">
        <property type="nucleotide sequence ID" value="XM_025605979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXN5"/>
    <dbReference type="STRING" id="1450535.A0A317VXN5"/>
    <dbReference type="GeneID" id="37108122"/>
    <dbReference type="OrthoDB" id="417112at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04336">
        <property type="entry name" value="AmmeMemoSam_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060:SF0">
        <property type="entry name" value="PROTEIN MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="370" mass="41201" checksum="0F536CEBFF9FE479" modified="2018-10-10" version="1">MQSQSRPATHAGSWYSDSPETVRYQIDYWLYEAKKELEDIASSLPKRGGRVTARIIIAPHAGFAYSGRCAAYAYKIWDLTNVKRIFVLGPAHHHYCSSLALPEYTAYHTPLAAEALPLDVDAIAELRAKKAIGQDQNPIDFATLTRAEDGEEHSIEMHLPFIHRMLQLQFPGQPPSKYPPLVPIVVGAIDDQTEQAFGNLLAPYLGDKDNAFVISSDFCHWGTRFDYTYFTAAAPSPGPLIPVSKDLPWPGLKEDDTTRLIEICQGGSRRTSRDAEIYNPPIYASISALDLGAMAAIATGRHEEFSRYLRDTRNTVCGRHPIGVIMAAVERLGLADTNLGRFRFIRYDRSSNVRVYKESSVSYASAFALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1G8</accession>
    <name>A0A317W1G8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_156234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465182.1">
        <property type="nucleotide sequence ID" value="XM_025605843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1G8"/>
    <dbReference type="STRING" id="1450535.A0A317W1G8"/>
    <dbReference type="GeneID" id="37107986"/>
    <dbReference type="OrthoDB" id="5359669at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="367" mass="40085" checksum="CDBF1196EB1747FD" modified="2018-10-10" version="1">MCPMLLNSLSDGPAMVLSPRQDHAFVQFPRQPKFTDTESRSFFSATNNLFPSKPSRKRSRDDSSFEEAINGNNTPMSLVSAPAPSTRKQEVEEPIYGEGMVLLNPRTKMAISAESQTGTWYEENVENVTTAAPISSRRADNPSSSGRKSQRLDPSAPSLDDITLSSIQRRLHSTEQQDDNRRTLNVGTRSEEPAVDDATRLLGISWQRIATDDSDMAAAVRGWKKYIDRQFAAYLGDSQILLKNRALNAYLVTARPTTPVGMANASAFFLFNDDLTQAQLVGSTWERCLMNLRSSPIVFEGTQILNAADRPLHNGMAPMGAQNILGANPVESGLPLLQTLCAQPMNLGIGMGLNNSVGMGTGMEIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2T9</accession>
    <name>A0A317W2T9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_558300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465508.1">
        <property type="nucleotide sequence ID" value="XM_025614000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2T9"/>
    <dbReference type="STRING" id="1450535.A0A317W2T9"/>
    <dbReference type="GeneID" id="37116143"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4100.10:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="4">
        <location>
            <begin position="78"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="5">
        <location>
            <begin position="351"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY80906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="557" mass="61912" checksum="6340E69B31891BC9" modified="2018-10-10" version="1">MSASCSALRRLTHRSPRTWPSRISSVFRPLSSSPSVVHPSLRTSSALPRVSRFSTMASLQHAAPVIPGDKPYDPEIKDMADYIHNYDVNSDLAYDTARLVFLDTLGCGLEALKFKECSKLLGPVVEGTVVPNGTRVPGTPYQLDPVNGAFNIGAMIRWLDYNDCWLAAEWGHPSDNLGGILAVADWVSRTNRAGGNIANGKIFQVKDVLEAMIKAHEIQGVLALENSFNKVGLDHVLLVKVATTAVVAKMLGLSEKQTADAITQAFVDGQSLRTYRHSPNTMSRKSWAAGDACQRAVNLVLKVQKGEGGLHTVLSAPVWGFYDVLFKGNKFQFQRPYGSYVMENVLFKVSYPAEFHSQTAIEAAEMVNVKLKALGKTAADIKEIRNRTHEACVRIIDKQFKAMDNFADRDHCVQYMVATMLVFNRLTANDYADGSEAATSPLLEDLRKRIYCVEDPQFTKDYHDPAKRTIPNALTVTLNDGTVLDEIVVEAPLGHRLRREEAKPEILAKYKRHLQAHFDQARIDQLVEVGWNRSALESYDVDKYVDLYVKDTLVAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W324</accession>
    <name>A0A317W324_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras GTPase activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_498006</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464899.1">
        <property type="nucleotide sequence ID" value="XM_025609333.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W324"/>
    <dbReference type="GeneID" id="37111476"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05127">
        <property type="entry name" value="RasGAP_IQGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="302"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY78590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1840" mass="210671" checksum="6311BE186B209752" modified="2018-10-10" version="1">MSSHLASLRRTQTDFPDQTSSPLRHGSTASTSSSIYTVSSSSFAPSRTSTVSSAASIGSVLGHRRGKSEVNTTISEEMSGGASQGKSWANAGAAYENIRRSLRPLSQAPNSSPNSSPSTTKPPAYRHNRSQTVDNPQYWKENRPQTPESRHAHHQEVETPKEKASYNDQSPTKASSPHNWSPHAVSPHAKSQVRAHHAHSLSNPPPITHTLSAPELETFQKSSTGHLRTLSKFAKSGETEEFALDSYGASVVGLQGRRRLKRTDTVTGNTGPVVGRKKPASAWAAGSWMDKQRQFLQAYEYLCHIGEAKEWIEEVIQKQIPPIVQLEEALRDGVTLAEVVQAMYPNRTFRIFRNPRLQYRHSDNIALFFRFLDEVELPELFRFELIDLYEKKNLPKVIHCVHALSWLMFKKGLVDFRMGNLVGQLEFEHHELEQTQKGLDKAGVSMPSFSGMAANFGAEPEPEPEPEPESEEDRIHRELHENEASIAEFQAQIKGAMLRLKLGNLMNDLWDFEPFLVELQSRIRGDWARQVVQYRLDMKTFAINLQAICRAFLVRNRQRGDKENYQAQELDVLRLQTLIRGAKARAQVNRVRTCMRKEEPGIKMIQAALRGALQRKTVYDLYEDTRGAEGEVLMLQAAIRGALQRKQFSKQYEATQAAEADVIEFQALVRGALQRSHFTKQYDAVHSTEPDVVELQALIRGALQRSHFTKQYDAVHSTEPDVVELQALIRGALQRSQFMKQYEAIRSAESGVIELQALIRGVFVRQEMSAQYENIDEAGVGTELLQALIRGMMARKSIQETKSSLAQEVPSITSIQAGARAFAIRNFQLQQAEALAKTEKECTSLQAIMRGNAVRAHLENLRQGLNQHIPAVIDLQSISRANAVRSFLDSQRASLKGEEASILALQSMARGIILRKKLDADADALEQEDLVITNLQALIRAAILRIDVGGILEQLDDCEDEVSQFQAQIRAMLVRVDVGQTLADLAAAEDVIMDLQSQIRGHLVRSRFEAKRRHYRENMDKVIKAQSFVRGRIQGQAYKSLTTGKNPPVGTVKGFVHLLNDSEFDFDEEIEFERTRKLVVQQVRQNELAEQYISQLDIKIALLVKNKITLDEVVKHQKHFGGHVGSLLPNREISSKDPFDLKALNKTSRRKLEQYQVFFFLLQTQSQYLARLFRRLRELNTAEKEYERIRHLMMGLFGYSQKRREEYYLIKLLARSAREEIESFDSLHEYLRCSSFWNKLFASYIKSPRDRKFMRDILGPIVRENVVENPDLDLESDPMQIYRSAINNEELRTGKRSRRRPDIPREEAIKDPETRATFIQHLQDLRDIADQFFAAFEELLYRMPFGIRYIAKQMYESLLQRFPRENPGFILQTAGHWVWRNYFHPAMVEPERYGVVDRGLTQEQKRNLSEISKVIAQVASGRLFGSENVYLQPLNTYIGDSIQRLGQIWGDMVSVQDAETYFDIDEFNDLYAKTKPTLYIKMSDIFSIHQLIASEIHYICQNPDDILKEVIRDLGNVKSNESELMSVNSSEISLTLNPKLAQVEDPEADVKALFMETKRCILYIIRVQTGANLWDIMVKSPTEEDEAKWMMLVRDELSANNTRQSAYSESNNMVDLASMSYSELKQTALENILQLEQTGKIRRDNYYQDLLNAIAIDIRTKHRRRIQRERELDSARMTLTRLNDQAIWLDQQLKTYNDYIEQAMVTLQNKKGKKRFLMPFTKQWDHQRELQKSGKVFKFGSYKYSARNLADKGVLVHWKGYTERQWDRVDLTISSNEVGVFTIDGSSGPMMVPGANAQVPLDDLLQAQFNNMQFLDFFDGHLRVNVNLFLHLIMRKFYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4P4</accession>
    <name>A0A317W4P4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_537136</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with MCM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465116.1">
        <property type="nucleotide sequence ID" value="XM_025612198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4P4"/>
    <dbReference type="STRING" id="1450535.A0A317W4P4"/>
    <dbReference type="GeneID" id="37114341"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000286">
        <property type="entry name" value="Homeobox transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF9">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 9 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="9">
        <location>
            <begin position="54"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="42"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="98"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="401"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="494"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY80257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="584" mass="63875" checksum="1001411ECD58007D" modified="2018-10-10" version="1">MSDPEPSAAAACASSPPPTQPSESAAALNYAFLVHSQKTLTQNLPPRVDNKLLARQKRRRTSPEDHAILESEYQQNPKPDKTARASIVSRVSLGEKEVQIWFQNRRQNDRRKSKPLQPHELLAPRSDVPDASKQSATDDNLPTEPGSSSGTENSEDNCQDTNPATQSSDNASFESDVVPGEKNELEQAVLSSQTSLATEVVEDSQKVPDETMPDPEPAQMHDEPPLDDSHQNSAKRKRSFSDIRGTRPFVQGSSTPGTFHGMKSPPSLRISLSFDGEAMVRKEGELTPSPPKGRNSLRIAMSSDGKAVIRADGEPSPSKNRISMFSARKPRFAGLQRSNSAVAFSTPRGGSMETERMFGRSRDPRNWESFFDTDARSALSTPTSSQSAPNAGSPAFFRARGQRSLTRSMSARHSSALHQSDYLNTPVPKPTGEKRRKISRTVSSLGRLETGRATLGDKLSNAKMLSGKEDELELQWGDSDKENWIPGTRVSHIRRRATSHHHSRRPILRETGSRDGKSNRDLASSGRYSRVSHSHHRASGVASKDVPEVDAEVSAFMNGGGGASQEEDLDCIQGLLSLSQGAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4U8</accession>
    <name>A0A317W4U8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_495981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465714.1">
        <property type="nucleotide sequence ID" value="XM_025609277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4U8"/>
    <dbReference type="STRING" id="1450535.A0A317W4U8"/>
    <dbReference type="GeneID" id="37111420"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF4">
        <property type="entry name" value="SIRQ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="8"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="419" mass="46308" checksum="DDCBC901C8716EB0" modified="2018-10-10" version="1">MTDSPNHAIVYGASGLNGWALINQLLAPYPSVHSFRKVTAFTNRPLDLSETYLPEPESHRPHLQLVSGVDLCGWDGPTLVRHLKEEVEDIEGVTHVYYLVFTAMDDDLEEVATNRRMLQNVIDAHNQISPRLQFVAFVGGTRGYGIYSPGGTFTPPLHEDMVNDLPSDYAKTVVYPEYREILKTSSKDKKWTWCEVCPDAIVGFTPNGSQFSLALHWAQYLSLYAYNNGIGPHTQAKGENNPVDIPFPGSTAGATSLFSPVSSNRLARFMIYASLHPETCGGGRLFNVADQETPCTYGSLWPRLASWFGLIGVGPAETAQETEHNTLKVGEVPERTSSLAPGEYIAKYRDIFAKYGCPKAITGGVGAGNRQLDSVGYWLTFDRQMSLKRLKETGFEADRDPVGGWLESFAMFRKAGLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4V9</accession>
    <name>A0A317W4V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_521219</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cell membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465201.1">
        <property type="nucleotide sequence ID" value="XM_025610140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4V9"/>
    <dbReference type="STRING" id="1450535.A0A317W4V9"/>
    <dbReference type="GeneID" id="37112283"/>
    <dbReference type="OrthoDB" id="44736at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF4">
        <property type="entry name" value="PROTEIN PNS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY80342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="532" mass="59283" checksum="C50F5B5B6E9D9F62" modified="2018-10-10" version="1">MSGQTSSYYNPPQGFGDQPQQQPYNYYQGQPAPNQYNGNYQGPEPKPPGPPQGPPPTYNQAVYGFDEAFKVERPKYNDIWAGLLLIAVFLGYVAVSGVTIHRYAQYKGFSGGGIYDSSNDFSLNTNTLVLFIFVLCVALAFSYAYFLGARYFSKLFIWVTGILNIVFALGTAIYYLVRKQYGGGIVFLIFGVFAIICFISWIPRIPFTAYMMEVSIDISRRYGHMFLVSTIGGLVAVAFAAWFSVTLVSIYVAYEPDSTGTNPACRSGGCSTARVIGLVIYVTFAMYWFSEWIKNTVHTTIAGIYGSWYFFSKSPQGMPQGATRGAFRRATTYSFGSISFGSLIIAIINMLRQACSVAQRQEAAQGSLLGSIMFWILGCFISMLDWFVTFFNRYAFCHIALYGKAYIPAAKDTWKMMKDRGVDALVNDCLVGPVLTMGSVFVSYVCALLAYLYLQFTNPAYNRDGDFTAVIMAFAFVIGLQICQIFMTPVGSGIETLFAAMAWDPQVLVHDHPEMYYRLVQLYPKVQEAIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4Z5</accession>
    <name>A0A317W4Z5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_587400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465764.1">
        <property type="nucleotide sequence ID" value="XM_025615824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4Z5"/>
    <dbReference type="STRING" id="1450535.A0A317W4Z5"/>
    <dbReference type="GeneID" id="37117967"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY81696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="61" mass="6799" checksum="1D4219539D8121D6" modified="2018-10-10" version="1">MRIADVGTGTRIRLTDLADKLPKFVRLDGLDISFDACPAREWLPPNMTCITGTSNKKYLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6D7</accession>
    <name>A0A317W6D7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ketoacyl-synt-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_602290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465474.1">
        <property type="nucleotide sequence ID" value="XM_025616423.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W6D7"/>
    <dbReference type="GeneID" id="37118566"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="23"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="941"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2281"/>
            <end position="2359"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="941"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1089"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY80872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2365" mass="257261" checksum="E19C3ED5063A31AA" modified="2018-10-10" version="1">MDPPGCPSALGVHLPPSVGVERSIPIAIVGIGCRLPGDISSPSHLWDFLAEGRSGLGEVPKSRFNNASYIGGSDEPATTRPWGGYFLREDIRNFDNEFFGISNREAAVMDPQQRKVLEVVFESLESAGVTLDEVSGANVGVYMASFSHDYIALQTKDPNSLTLHSHQGMGVTILGNRISHVFNLKGPSCTLDTACSSSLYALHLACTALQNGDCDAAVVAGVNLIQSPDLHIAVSQGGVLSPTSQCHTFDASADGYARADGVNAIYIKRLDDAIRNHDVVRSIIRGTATNSNGRTPGIAQPSIDGQEAVVRKAYARAGLDPGQTAYVETHGTGTKVGDPVEVEALSRVFRKYQRASATLLGSVKPNLGHGEATSGLSSLIKATLALEHKKIPATIGVKNINPAIRAKEWGVEVVTRMSSFPQSPGRHPHRISVSSFGYGGANAHAILEEATCLPNQVSYTNGWTTGAGDQSLGEFALPYLLPFSANHLRSLEGRVERLSHLNLSAVSLQDLAYTLGERRSHLARRGYVIAHPKTMSQDINVDNLRLSTTGRGLVDDKLAFVFTGQGAQWKGMARQLLHFPTFADTVRQLDADLSSLPHPPDWRIFDILLDDSDCCPINQAAFAQPITTAVQIGLVTLLRSWSIRAEAVIGHSSGEIAAAYAAGLLSTREAIILAYYRGYAVTQQAPSGAMAAIGLNPKAALDWITQLDLSATIQVACINSPSSVTISGDREGIETIIAALQADGIFARILKTDGKAYHSHHMASVGKGYEQLLVEAAIFSRDESTTVVSHQIPMYSTVFCKPLEYQLARTTTYWRSNLESPVRFCEGLTGLSELVKHPSWVEIGPHAALKLPIMQTLGQSASYVSSLDRGQDSAVALLNLIGRLFVQGFKVDFSKLLVSYPHDRNSRFIYDLPTYAWHYAEPLWNESRTSRESRHRQHPRHELLGAEVPGGSPTSFSWRNLLCLDHVPWLREHRLGDTAVFPATGYIAMALEALVQKGLPAGVDLGHECVVLRDVALVKALPLEDEGSVELFTELRRLPLSNVRSSMHWWEFQISTIFEDSSYAIRAKGLIRLDSTPDSTYSIPSSNCDLTPQSRHLWYGTSAQLGLEYGPTFQQMYDIQTPDCKGVLYAEARTQTLAPDIPGGAQPHPRYFLHPVLLDTILQVGAIACNGGSIQGMVSRVPTHLGEIRMRLASKAADDGGSICAISTVTNFNKHHVTAALVDHRQAPVAQFTDVEMTTFVGPKRREARYPIGRVNWKPDITQIPDDSAFSSALTRVLAVTNLGGFEAHARFLAALNLIVHKQPDCRILSLTTDLPLVALCLVEVLDAVQVHRRFETFSLGRIGLDGMLEVADIRTYSAPLELSSVPFRKATPDDQFGLCILGDGMAVADQLGSHTNDRTFFLGPNTAIVSLLAGSHLPLTDSTHRVQVLRPVVKFTPTFSQIILIGAESVDSQLAEYLSADSGLSVQALSLYNLLACSSPITPQTLVVSTIELHRSVLADPTSEEFDALKQIIEHAAHLVWITGCGVHKGFDPTQSLFIGLARALVIEQPMMKIVSLQLDPATEVAVLSHDIMRIVRQEGSVDCEFIRDGSHLLISRIVPDEQLNRHFQIRQDNIACPTPLSQAGNASLSVPEAGPLSTAQFVRRPPLGPLATDHVLVKVACFGLNAKDVYALTGRVPTKDATCGFELTGHIVDVGDKVRDESSFTVGDRVAVMYNGHFSPYEAVPAWSCVKLQESEDLSIMAGVLVAFVTAVYALEHRAHLEQGESILIHSAAGAVGMATIQLAQHLGAGEIYATVGTAEKKHFLVERFGLRPENVFSSRSTEFAAQIQTHTQGRGVDVVLNSLVGDLLHESWECLAEWGRFVEIGKRDILDSGRLDMRTLLRGTTFTAFDLGMLGESTSTGMARQLTPRLLSRVMSLLRAGHVKPIQPLTVFPVRDLTAAFNHFNNAKRMGKIVISFEDPTQMVPVVPERFSTTFSPAKSYLLVGCLGGLGRSLSRWMMSRGARRFVFLGRTGLAKPAARLMVEQLEQAGAHCTVMTGDVSLSDDVERAVATAMADAPLGGVVQAAMGLHEAIFKYMPRENWLTGTQAKVRGTWNLHHALGKLGCEADLDFFLLTSSIAGQLGTATEGNYCAANHFLDVFARYRYSLGLRAISLGLGSISEIGYLHEHSDIGDLLLRKGIRPLPEHEVLQVIDIALSSEQHQTMRDPLSQCHILTGIEDTGLQEHRKQGYTGFWQCLDDPRFSVLTSALQRRAAQSEGAINTPASVIQTALVSGDEAQLRTAVTQAIAKKMSNIILLPLPRLDLKVSLGNYGMDSMLAAELRQYIFSSMDVDVPFLMLMDAKTTVMSVVELVVEQLGKRWSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6G3</accession>
    <name>A0A317W6G3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_625998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465504.1">
        <property type="nucleotide sequence ID" value="XM_025617327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6G3"/>
    <dbReference type="STRING" id="1450535.A0A317W6G3"/>
    <dbReference type="GeneID" id="37119470"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676:SF41">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY80902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18591" checksum="C8607EED216300CF" modified="2018-10-10" version="1">MAGDTHKAGIVGVVVGAVLLFAAMSMVPFIVMWHHRRRTIARRDSELRNLTHGGTMRQVSVERWLEEQTHADHSDRQYAQESCAICLSGLAASQDTLPFPEPACIAPSPRNETNLQDPMETGRVCGGRNILVLNRCHHVFHASCLAAWFQYHQHRCPICQTAYSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W7B1</accession>
    <name>A0A317W7B1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_152105</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465500.1">
        <property type="nucleotide sequence ID" value="XM_025605806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W7B1"/>
    <dbReference type="STRING" id="1450535.A0A317W7B1"/>
    <dbReference type="GeneID" id="37107949"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY80898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="463" mass="51164" checksum="CF76823004C3221E" modified="2018-10-10" version="1">MALPMSIRPTTRHASRLAQSLRTSRSYSTEPDLKTTLKSVIPDKRELFQEVKARSDTVVGEVKIGSIIGGMRGLKSMLWEGSVLDPEEGIRFHGKTIKDCQRELPKGTTGTEMLPEAMFWLLLTGQVPTTSQVRAFSRELAEKSHLPDHILGLIKSFPRNMHPMTQLSIAVAALNTESAFAKAYERGLNKAEYWEPTFDDSISLLAKIPRVAALVFRPDEVDIVGRQTLDATQDWSHNFAELLGKGGSEHADFHDLLRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEVLRWILAMQEKIGTQLTDDSVRTYLWDTLKSGRVVPGYGHGVLRKPDPRFEALMDFAATREDVLANPVFQLVKKNSEIAPAVLTEHGKTKNPHPNVDAASGVLFYHYGFQQPLYYTVTFGVSRALGPLVQLIWDRALGLPIERPKSINLLGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W910</accession>
    <name>A0A317W910_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PEBP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_536941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465800.1">
        <property type="nucleotide sequence ID" value="XM_025612155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W910"/>
    <dbReference type="STRING" id="1450535.A0A317W910"/>
    <dbReference type="GeneID" id="37114298"/>
    <dbReference type="OrthoDB" id="10251855at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00457">
        <property type="entry name" value="PEBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049556">
        <property type="entry name" value="PhiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289:SF1">
        <property type="entry name" value="PEBP (PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY81732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="206" mass="22462" checksum="A0BF08B385A4AD2F" modified="2018-10-10" version="1">MEKLPPRVEAFLGRLLRNKRGRDAKLLTRVSPVIQAIQPTIAVTSPVGPSPAPLPQEYTPLGENRFPPLSWTIPGDITPDQINSYVLIVEDPDAPLPSPIVHGLYYGIPKDKTAVSSDDVVLADAAKRTLQGGFQYGVNWHQNVWSGPRPVLAHGPHRYFFQLLALGQPLAGVAEKPLGKGELLEALGKSNVLAWGEWVGTFVRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WB28</accession>
    <name>A0A317WB28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_469016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466162.1">
        <property type="nucleotide sequence ID" value="XM_025608283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WB28"/>
    <dbReference type="STRING" id="1450535.A0A317WB28"/>
    <dbReference type="GeneID" id="37110426"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="340" mass="38038" checksum="8CBEDC157869CF32" modified="2018-10-10" version="1">MLVTRQLGRNGPLVPAQGLGLMGLSMFYNTRRPDAERLKFLDYAHAQGATFWDSADVYADNEDIIGKWFQTTNKRKDIFLATKFGIQQHPGLPASIHNSPEYVREACLRSRQRLGLAANDPIDLYYCHRIDPQQPIEITVAAMADLVRDGLVKYLGLSECSAETLRRAHKVHPITAVQVEVSPFATEALENGLLDACQELGVALIAYSPFSRGFFTGQLTSWDDFDESDRRRVLPRFSKENFHKNVEIVRRFEEVARRKGCSVGQLTLAWVAGLFELSFPIPGTTKEANLVENLGSLAIELTEEEQAAVQAVVDEAVVHGDRHPSSMMPYLYVDTVPLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBZ8</accession>
    <name>A0A317WBZ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_536415</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466197.1">
        <property type="nucleotide sequence ID" value="XM_025612013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBZ8"/>
    <dbReference type="STRING" id="1450535.A0A317WBZ8"/>
    <dbReference type="GeneID" id="37114156"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000176">
        <property type="entry name" value="tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="21"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY83729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="427" mass="46561" checksum="1CBAFDFCAC940280" modified="2018-10-10" version="1">MGKSSKDKRDAYYRLAKEQNWRARSAFKLIQIDEQFDLFEHENPEKVTRVVDLCAAPGSWSQVLSRVLIKGESFGRRAWVEKKRKEREALERVQNGGDTTPAANEDTDMAELKPRKNVKIVSIDLQPMAPLEGITTLKADITHPSTIPLLLRALDPEAYDSTTSSSPSAVRPPHPVDLVISDGAPDVTGLHDLDIYIQSQLLYSALNLAMGVLRPGGKFVAKIFRGRDVDLLYAQLRTVFEKVSVAKPRSSRASSLEAFVVCEGFIPPSIHAGTDALKNPVFGGVAVPAPVSTDGNVAVEVREGNDEAEPIKVTHLAPAATTLASESTQLQANLLHADSLASVTPVPLAYKPLSEKFAVENRWIPRFIACGDLSAWDSDASYTLPPDHVSLDPVQPPTAPPYRRALELRKEKGGAYGKTKLGSMGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WC08</accession>
    <name>A0A317WC08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">BO94DRAFT_536773</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WC08"/>
    <dbReference type="STRING" id="1450535.A0A317WC08"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="157"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="424"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="762"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="322"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY83301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="787" mass="87805" checksum="9FD81F1632ED4205" modified="2018-10-10" version="1">MNASKLSKKRKAVTRDVEEEAGVFSGDELNVGDINGALSDNANELSSDEEDSEVELIDDFSDEENDDEEEELDSDEIPSDGEEPLNKKAGTPAADLEVPTNDESSSEEEAEVNFRIEKDANGNDRYIYDEINPDDNSDYSDIEENANTIGNIPLSFYDQYPHIGYDINGKKIMRPAKGEALDALLDSIEIPKGFTGLTDPSTGKPLELSQDELELLRKVQMNEIPAEGYDPYEPLMEWFSNKQEVMPLSAAPEPKRRFVPSKHEAKRVMKIVKAIREGRILPYKPPSEEKEESLDLVSFDLWADEAERPDHPMHIPAPKLPPPGYEESYHPPPEYLPNNKERKAWEEADPEDREQEYLPTDFGSLRKVPGYGEFVKEKFERCLDLYLAPRVRRSKLNIDPESLLPKLPSPEELKPFPSVCATVFRGHKGRVRSLAVDPTGVWLATGGDDGTVRVWELLTGRQLYSVKVGEEDAVNVVRWRPGKDAVVLAAAAGDDLFLIVPPILDPELEQASLELMDAGWGYAASKPTPKASEEKKTTPPQWVRPSPALADSGVCAVIPLRYVAKSISWHRRGDYFVTVCPGSSTPASMAIAIHTVSKHLTQYPFSRRIKGGGPPQTAHFHPSKPILFVANQRTVRAYDLSRQLLVKIVQPGARWISSFDIHPTSSTASGGDNLIVGSYDRRLLWHDLELSQRPYKTLRYHRKAIRAVKFHPSGRYPLFADASDDGSLQIFHGSVTGDMLSNASIVPLKVLKGHKITGELGVLDLDWHPREAWCVSAGADGTCRLWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WC68</accession>
    <name>A0A317WC68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_557659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466287.1">
        <property type="nucleotide sequence ID" value="XM_025613945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WC68"/>
    <dbReference type="STRING" id="1450535.A0A317WC68"/>
    <dbReference type="GeneID" id="37116088"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF11">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="553" mass="62513" checksum="7D0437B91203757B" modified="2018-10-10" version="1">MPSRESIPVESTEYKVDPSRYAFSPRKLRVVCIGAGFSGLILAHKLKHEQPLDFVDFTLYEKNTDFGGTWFENIYPGVGCDVPAHSYIFPFEPNPSWSKCYAGGPEIEQYIKDTVEKYGLKERIVFNTRLVKSIWNEERGKWALELQQNDAIIHDEADVLINAGGILNRWRIPNIEGLNQFEGKVLHTAGWDKTYDWSGKNIAVIGNGSSGLQIVPALQPKAAKIVNFIRQPTWVSVNLCPDVTKDGMGTNFEYTDEDIIKFREDPEGFLEYRKFIERSVNTVYKIMLKGSDLNRMILVATDGVMRQRLSKNPELIDKLVPKTEIGCRRLSPGDGYLEAMQEPNAEWCFDPIERITKTGIQTTEGEQDFDLIVCATGFDTTFIPGWEMVGRDERQLALDWRKTPQAYFSVCAPGSPNYFVFAGPNCPIGHGSVPQMLGWSADYMLQWVKKIAREDIHSIAVRDSAIALYNRHAQANLKHTVWSTGCAAWYNNGSAVTAMYPGSVLHFKEAISSIRGEDFDIRYNNTANPFAYLGNGELEWERAEGADLAFYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE85</accession>
    <name>A0A317WE85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_110480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466618.1">
        <property type="nucleotide sequence ID" value="XM_025605500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE85"/>
    <dbReference type="GeneID" id="37107643"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="171" mass="19943" checksum="5B35EC97F76A1F07" modified="2018-10-10" version="1">MTGLILHAPGDPLEQPLFTWFLLILSLFLPFSFFCCLCSLAVRDPYDTSTVPKPDRTPTLGSQIHVTVLYKYLTKPPTEIPRLLFSSLSFDFILFYFFQFFLGLFQLASIFGPFSLPSLKRAIILSRVLFHYYYYIFILFFPLLSLIHTYTHPSTLPFFFFALDPLFSLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEJ1</accession>
    <name>A0A317WEJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_494679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466115.1">
        <property type="nucleotide sequence ID" value="XM_025609239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEJ1"/>
    <dbReference type="GeneID" id="37111382"/>
    <dbReference type="OrthoDB" id="4505774at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="67" mass="7761" checksum="CEAC466D6AE1DAC5" modified="2018-10-10" version="1" fragment="single">MTERSRVYLTYHITVQMQQSHSSSPQSQPKQGLETVLMGFLMEEPELEDGRAKLTDEEKEEAAMVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFN9</accession>
    <name>A0A317WFN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_599227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466296.1">
        <property type="nucleotide sequence ID" value="XM_025616305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFN9"/>
    <dbReference type="STRING" id="1450535.A0A317WFN9"/>
    <dbReference type="GeneID" id="37118448"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016314694" evidence="1">
        <location>
            <begin position="20"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="372" mass="41092" checksum="9095DD918159276C" modified="2018-10-10" version="1">MHLLPTIAALSAIITHILASPLMDTFLQIPELSTYAHVYNLTGGIVEINPLFTKRYNYDEDKRNYTFLAPTNAAWSKIPAPIFDILMTQQAYPLTEALLRTHIIEARLTASDLTNIISTQGAGGIATSLQLSNTTAQYHHGILTKTVQGYYIDSRTSSNCTVQIDDQAAIVTPDIEADNGLIHTIDQVIDPFLIYGGGPSNRTAKPTMETTNLTIGGLLATDSRLVNSSKILKINSPDTLRRLSTQSNEKQFFVAPHNEAYDLMPTILPVFHTLVAPYKSPFNTLMWQYGWLDSNGEKLSGLSFDSPLTVTSDITGLNLTVTQSNGAIFIMNAGLVTQVETSNGYLWIVDRWLDPLYEAFGPVDRFGMLEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WGG3</accession>
    <name>A0A317WGG3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_536740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466055.1">
        <property type="nucleotide sequence ID" value="XM_025612094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WGG3"/>
    <dbReference type="STRING" id="1450535.A0A317WGG3"/>
    <dbReference type="GeneID" id="37114237"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000024">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="200" mass="21913" checksum="CE9A577D88731CBF" modified="2018-10-10" version="1">MTSRLVLVIGDLFIPDRAPDLPAKFRKLLTPGKIGQILCLGNLTDRSTFELLRQVAPDLQLVKGDFDVDSPNLPLSKVVTHGSLRIGFTHGHTIIPPGDADALLIAARQMDVDILLWGGTHRFEAFELEGRFFVNPGSATGAMSTGYWPEGEEPTPSFCLMDIQGDVLVLYVYQLKTDANGVETVAVEKVSFRKNNFPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHQ0</accession>
    <name>A0A317WHQ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_598952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466188.1">
        <property type="nucleotide sequence ID" value="XM_025616292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHQ0"/>
    <dbReference type="STRING" id="1450535.A0A317WHQ0"/>
    <dbReference type="GeneID" id="37118435"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="61"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY83720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="409" mass="46733" checksum="48DECAA2873F6AA4" modified="2018-10-10" version="1">MRLRLLDAIPGEVANAVPRVFPTTGFEIIDPTEEIEEETLPTYRAEKYYPVRLGEVLDGQYQILAKLGYGVTSTVWLARDLSDSKYVALKIYVCGSERNHELGVYDRINTVESDHLGRSFIRKLWGHFFLNGPHGRHICLVHQPLGLSVDQFLYFLPGKVMGLEDLKPCLRQILGVVDFLHTDAHIIHTDLQLKNLLLPGDDPQILSGIEESEIEAPSPRKILDHGRTIHTSQLVIPGNGLPMLSDFGEARFSEEQHDEDIMPNVYRAPEVVLKMNWDNKVDVWNIALMAWDLVCDQTLFSGRNRDGIFDDRAHLAEMMAILGPPPSEFIKRSKVGSVFWNDNGTWKDLAPVPRITLEKRAASIQGQDQEGFLRFMRRALKWRPEDRPTARELLFDGWLMKGLEFRNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WI34</accession>
    <name>A0A317WI34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_576266</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466338.1">
        <property type="nucleotide sequence ID" value="XM_025615128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WI34"/>
    <dbReference type="GeneID" id="37117271"/>
    <dbReference type="OrthoDB" id="4245873at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16985" checksum="958AD9CB54BF6B5D" modified="2018-10-10" version="1">MSFSIQFESAGIYHIGTPSQQMLVSFEELLGFHAGIIGLLEYGHGWRVTKAAIRRLIARLRWRPMDSPYSVCIDSSGPIYYVITHGEDAIRITAQELDASLFGRVIKKQWDRGTDDGWVVIGLSILRAFVYGMWKNLAYQMRWRKVGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WIQ4</accession>
    <name>A0A317WIQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_80072</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466945.1">
        <property type="nucleotide sequence ID" value="XM_025617668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WIQ4"/>
    <dbReference type="STRING" id="1450535.A0A317WIQ4"/>
    <dbReference type="GeneID" id="37119811"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098588">
        <property type="term" value="C:bounding membrane of organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034488">
        <property type="term" value="P:basic amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000011">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000026">
        <property type="entry name" value="PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF35">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER YPQ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="105"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY86354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="390" mass="42968" checksum="77B108CA4B446CA9" modified="2018-10-10" version="1">MFPAVTGNIDLEALSGICGSISIACWVVVFSPQIIENFRRGSADGLSLLFLIVWLAGDVFNILGAVLQGVLPTMIILAVYYTLADIVLLAQCFYYRGFILRDEPSTPPRPSSPIPAEESYDEDTEIPSPVMPRKPTEQTALLSSKQRSVSCQAPLGGPSPASSTTITPQHHQPLLAHRRHSASSFLHIAVDGTHLSPVTPFVERTKEPRPPRALTVLQSVLFNGSAIIIVCAAGFLGWYISQRSSLSSDEDDNRDDNHTDDLTMDPLGQVFGYLCAVLYLGSRLPQILLNYRRKSTDGVSLLFFLFACIGNLTYVLSILAYSPVCEHESSSRHGRCRPDELASLYGQYILVNLSWLIGSFGTLLLDMCIFIQFFLYQDSNGGDVDVERRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WK63</accession>
    <name>A0A317WK63_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Putative gamma-glutamylcyclotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_624647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamylcyclotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467046.1">
        <property type="nucleotide sequence ID" value="XM_025617236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WK63"/>
    <dbReference type="GeneID" id="37119379"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045038">
        <property type="entry name" value="AIG2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31544:SF2">
        <property type="entry name" value="AIG2-LIKE PROTEIN D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY86455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17775" checksum="91B34691B917A66E" modified="2018-10-10" version="1">MGDHVLFFYGTLMAPQILHRVIHGQAVPEPWQKALLTIKPAILHNYRRHRVQGADYPGIVPVSEGEDAGAGPGPSVLGTVVWGLTDGDVFRLDRFEGRGGEEGKVRGLLDAAGGAKEGKEVEAVTYVWTAGEERLEGAEWDFEAFKRDKLAWWVEADEEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL30</accession>
    <name>A0A317WL30_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pectin lyase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_596188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467301.1">
        <property type="nucleotide sequence ID" value="XM_025616245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL30"/>
    <dbReference type="STRING" id="1450535.A0A317WL30"/>
    <dbReference type="GeneID" id="37118388"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="5">
        <location>
            <begin position="77"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="5">
        <location>
            <begin position="446"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY87093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="920" mass="100074" checksum="84848FC996DF4F37" modified="2018-10-10" version="1">MVNNQPNVFGAAPDKGSMNGPITSDAQLLHYDESAYHTNRTGTNSTARSLHRRSSDFWMDDITHGEMPFAPSGYEFYRNVMDYGATGDGTTDDTAAINRAVSDGNRCGENCGSTSVLGALVYFPPGTYLISTPIVQYYYTQFVGDPNDRPIIKGSANFTGIALIDTDPYIPGGSGSEWYINQNQFYRQIRNFELDMTEMNFTNYDAGQAYVPTGIHWQVAQATSMQNIYFNMPESTSEETTTAVGIFMENGSGGFLSDLEFYGGNIGFRAGTQQYTARNLKFTSCLTGVSMIWDWGFTWKNVEFDGVWVAFDCTSVGSEDSQGTGSIAVVDSTFYSVPYPITLRDGGPYPDIILDNLLVQDSASIVLISGGDTLFEGSSGSIYIESWAYGRRYTSIDGTGTETYGLLDVSPDKPESLLDGDGDYFTKSRPQYDTYSASDFIVATAHNISNDATGDQTDAINTLLSDNVGSPIFFPAGIYLVKSTVFVPVGSIIVGEGWSQIMGTGEYFEDELSPQVMVQVGYEGDSGTLEISDMLFTVKGPTAGAILMEWNVRESTQGSAGMWDSHFRVGGANGTDLQMSDCPKSDTVNKDCMAASMLLHLTPTSSGYFENVWAWVADHDLDVQISSNDTDTSATQLNIYAARGVLIESQGPTWFYGCASEHSILYQYQLYNAKDIYLGHIQTESPYFQDTPAADKPYTIGTFESDPTFEDCTSGSNCEKAWALQVLSSENVFIYSAGLYSFFESYSEDCLDDESCQERLMETSYTQGLWMYNLFTIGATEMVYPDGGVIPPTYQADNKNGYSTDISAWLVLSEQGADIGSSGNEEEDGSGVVYIDPIVFGEPSPIFQCYPPCTMVMPTSTSNTSSTVTYAPWSTHVVVGGSTVSAGATSAHTTTVVWSPITSASGPFTSQTVKPDSPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL60</accession>
    <name>A0A317WL60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="10">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_466274</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467432.1">
        <property type="nucleotide sequence ID" value="XM_025608154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL60"/>
    <dbReference type="STRING" id="1450535.A0A317WL60"/>
    <dbReference type="GeneID" id="37110297"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY87224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="116" mass="12839" checksum="7163C5EBDBCDB07D" modified="2018-10-10" version="1">MGKLTSTIGIPIKLLNEAQGHVVTLEITSGVVYRGKLLEAEDNMNVQLKDITVTARDGRVSHLDQVYIRGSHVKFFIVPDMLRNAPMFRSRGQRGRGVGLARGKATVQRARGQRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WML5</accession>
    <name>A0A317WML5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTPase binding protein Rid1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_74841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467523.1">
        <property type="nucleotide sequence ID" value="XM_025617644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WML5"/>
    <dbReference type="GeneID" id="37119787"/>
    <dbReference type="OrthoDB" id="2155261at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formin GTPase-binding" evidence="2">
        <location>
            <begin position="332"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="793"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="850" mass="95056" checksum="4B4645962345D5A9" modified="2018-10-10" version="1">MAPSMQPPNIFDDSTRTPTKPSVLRAIWSSKAHKRTSSADDVLAPRAVDKSQPRGNPFAPPVDGPYTTADQQPLAEIAPNRDAADVSSTQRSPGKQGKHTLHKKTKSAVSLKSLKSYMERKDKSDETPDDEAANFKPKKAKSANSLSAILKRSQRGRKAENSKGSRDKENRSPSDPVDSMPSTAWSQYPTPSYHDQPEITGSPHKPRTLQEEVSLYTPREYGPALQRNFYDYDRPSLRTRGDPKPRPKSDYLAGNRKAQELMDPIESMSSNKLAPVNPPESASKKKGRPRALSRPEYHPQVEARPEQSPKRVSRVQAAISAFNAKEQQVELQKRLNAKDLESEFEKLLDARNIPHNMRDKMRSLDTNIKADFIRKDRAENTTPHSAGASATDSTGRRGRKKEAKEDRQGQDSKGSRSRSRSRGFTFSKGSSSPKKQRPDSGSFYRRPKSADYSQPTGFSRTGTPSASTTSLAATACDTAADPSDFVHYLREIQKPEMVEIGKMHKLRLLLRNETVSWVDTFIADGGMDEVVQLLYRIMKVEWREEHEDNLLHETLLCLKALCTTSIALQHLTNIEEQLFPALLKMLFDEEKKGPSEYTTRGIIMNLLFTQLSMVSSDEMAARRASRILSYLRDPVPPEESQPLSFIANIYQSRPYRIWCKEITNVTKEVFWIFLHHLNVVPILKDDKPGTTFRERHFPAPRPPVPAAPYVGGVEWDATNYLAAHLDLLNGLVASLPTIEERNQLRAEFRASGFEKVMGGTMRTCKEKFYSSVHDCLKTWVAAAVDDGWPYISVREGPPRPEPGSPTKSPIKTPGSPRKGVLDEQPPKLELALDVPAGSGVSQGNGLGNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN76</accession>
    <name>A0A317WN76_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_70938</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467419.1">
        <property type="nucleotide sequence ID" value="XM_025617614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN76"/>
    <dbReference type="STRING" id="1450535.A0A317WN76"/>
    <dbReference type="GeneID" id="37119757"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706:SF2">
        <property type="entry name" value="RFEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34706">
        <property type="entry name" value="SLR1338 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="281"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="629" mass="66237" checksum="AA3265FDDF9F7AF7" modified="2018-10-10" version="1">MSRPYYNQQGYPPQLRPGSAQQSPYPTSPQQQYQAYAPPSVPPNKPVPSPSPGPHSAYSAPQSAYPNSQSPYPGPGYASQSPAPQSYSPAPGYPSQSPAPQAYSPSPYGSQAPPQQGYPQQSPYGTREPPSGQYGQSQQGYGRPPPPPPQAQPYGASGQQYPQQQSSQGPSYPPQNAPYPGGPGRPPQQGPPAGGPGAPYGAAGGAPPATRATEQQIAAYRQLLIGTIQEKGLQSFWPPGRLDELVQTLANEAPAKVNKLMNELRVPQEVAMDIMKLSLFDVILYVDDSGSIEFEERGVRKEQLKQIIEIVAAAASTFDDDGISVRFMNNAEQGDGIRNADDVGRLVSRVRFQGLTPLGTSLRSKVLDPMVVGPARAGRLQKPVLIITITDGQPAGEPLDSVSSSIGYAVGEVSRTQYGQGAVSFQFSQVGNDTKARDFLASLDEDPRIGMLIDCTSNFEVEQDEMSRAVPPVYLTRELWCAKLMLGAIDSSYDTKDEKAAGRNAAAGAPPSGPPSGPPGGAPRGGNQYGSYDQGGYYNQGPAPSYGQPQQGSYGSGQGYGQGYGQGYNQAPYPPSQGQGQGPAPGYGQSYGGYGAASPHPNQPGYGQSSAGATRGYSPYGVPPAPPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN86</accession>
    <name>A0A317WN86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_535824</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34935"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58141"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466707.1">
        <property type="nucleotide sequence ID" value="XM_025611873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN86"/>
    <dbReference type="STRING" id="1450535.A0A317WN86"/>
    <dbReference type="GeneID" id="37114016"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.200:FF:000001">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.230:FF:000002">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="151"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY85690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="656" mass="74338" checksum="ED661815ADD53B77" modified="2018-10-10" version="1">MASVTTKTGQVVDRSVLDSMLRRRLFYTPSFEIYGGVSGLYDYGPPGCAVLNNIVDLWRKHFVLEEDMLEVDCSMLTPHEILKTSGHVDKFADWMCKDPKTGEIFRADHLVEEVLESRLKGDKEARGQKVEVDEEKEAKKKKKVKQTKVVKLDDAVVKEYEEILAQIDNFDGPALEKIITKYDIRNPTTDGNLLPPVAFNLMFQTSIGPSSNMPGYLRPETAQGQFLNFQKLLEFNQQSMPFASASIGKSFRNEISPRAGLLRVREFLMAEIEHFVDPEGGKKHTRFEEVKDVEMTLLNRDIQLSGSTKTEQMTIGKAVETGLVDNETLGYFLARIQQFLFKLGVDPKKLRFRQHMANEMAHYAADCWDAELQTSYGWIECVGCADRSAYDLTVHKNKTGAPLVVRETRAEPLRVEEWQIDLDKKKFGPRFKKDGKSVTAAIDALSQELREKLALDLEQTGKIEVEVEGVPSGKVELDKELIKIEKRTRVENVREYTPNVIEPSFGIGRILYSMIEQVYWSREGDEARGVLSFPPAIAPTKVLIVPLSTHSSFAPLVQRMTTKLRRMGVSNRVDDSSASIGKRYARNDELGTPFGVTVDFQSVKDNTFTLRDRDSTKQVRASEDEIAQAIKALVEGEETWEDVRQRLPEFTGQEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNK4</accession>
    <name>A0A317WNK4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_85443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467109.1">
        <property type="nucleotide sequence ID" value="XM_025617711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNK4"/>
    <dbReference type="STRING" id="1450535.A0A317WNK4"/>
    <dbReference type="GeneID" id="37119854"/>
    <dbReference type="OrthoDB" id="5062908at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="425"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY86518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="587" mass="64785" checksum="20064F5D300266ED" modified="2018-10-10" version="1">MSTKIKHDPENMSLSQSSLHTMDQMSQPRPNQMIPGIPNMASRGLQDDDLSSQDNFSLCSSTHPNHGTPSDLKGWSLSDVDALDSGAMSKPESPEVQMLSFSFSQQLLPSTVGPSDVMYHHAGSDFSGIQDMTEPNDLDFSHAHDFNHYSSLVDFSAFDNDVCGQNGTQSSCTPDDALSHSSHTDDGHLAANEAWNSIVADTRNYQGSPMDQYTTGMFQSVPVSPPLSDASNDISVTSSCSGYPTFMSHEDAMLKDVTTTPVGSHGINLGDPLFPLTPPLSEQDPNRTIRASKNARRPALQTSLSQPQVKQDPEFFPPLPVKETLRQKAKEGADLRNPRDHPYYSLPTHSDGKYYCPFANGEKPCNHPPTTQKCAYHKYLDSHLKPYRCKVAACMDAQLQFSSNACLFRHEREAHGFHGHGDNPHLCLFEGCDRSVPGYGFPRRWNLFDHMRRVHDFASSDRHSSPDASPTTGPAKKKETAGRKRRVAGVTGAPTMKRTRSTQSQTNPLKAAQQTSAHHGQRLQNAERNYYNCRSRLLEELTNITPQDSSMHEKVNASLQELITLGLNYRHIEASQAAAQIAHGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPZ6</accession>
    <name>A0A317WPZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_556538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467898.1">
        <property type="nucleotide sequence ID" value="XM_025613871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPZ6"/>
    <dbReference type="STRING" id="1450535.A0A317WPZ6"/>
    <dbReference type="GeneID" id="37116014"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="64"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="405" mass="43709" checksum="8600487169158116" modified="2018-10-10" version="1">MKPIINRLDDDTVQLPHAVSLGTGLWQMRNAPVPATQKAIITPQMKSTLNQELNAIPVQDPGLGEVLVRILYSGICRSDASFSIGPLPGYPKHNHIAGHEGIGHVVKSHYPALVGRVYGLRYLGSSCGHCTYCLRGLVTSCPSQMNIPKQIPGTFQQYVTVPTNCLIPIPEPLLGDDMDWALYTSALCSGSTALTSLRAANLNPGDVVIVVGIAGAIGHLTGAIAKHVLKSRVIGIDFQSKIEALAENKDDYADILLSAADTTDDNTWEELHARLLESCEKLRGGQGLSRMAEAVVVTSSSFAAFQHLEEYVCDGGRIVCVGVPKGLNMLQIPLHAIVERNLFVTGNLMGGQQEVLQVMEYIRSGWIKPKITKIGMEEIPVWMQNLVDCRTVGKVVAMINGLVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQB6</accession>
    <name>A0A317WQB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">U6 snRNA-associated Sm-like protein LSm7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_465023</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467981.1">
        <property type="nucleotide sequence ID" value="XM_025608094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQB6"/>
    <dbReference type="STRING" id="1450535.A0A317WQB6"/>
    <dbReference type="GeneID" id="37110237"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000043">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="46"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY88619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="134" mass="14391" checksum="71C7F4ADF8C65594" modified="2018-10-10" version="1">MSERGSFRGGARGRGGGYDRAGGRGAHKSGGAGGGAQQQQEKPKKENILDLNKYMDKEVRVKFNGGREVTGLLKGYDQLMNLVLDDVKEGMRDDEGNENTRSLGLIVARGTLIVLISPADGSEEIANPFVQPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSB3</accession>
    <name>A0A317WSB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MACPF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_624296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467288.1">
        <property type="nucleotide sequence ID" value="XM_025617204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSB3"/>
    <dbReference type="STRING" id="1450535.A0A317WSB3"/>
    <dbReference type="GeneID" id="37119347"/>
    <dbReference type="OrthoDB" id="2562973at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054586">
        <property type="entry name" value="MACPF_1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22693">
        <property type="entry name" value="MACPF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MACPF-like" evidence="1">
        <location>
            <begin position="342"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="743" mass="81191" checksum="C19491698E6D00B9" modified="2018-10-10" version="1">MSSLLKGAATAATTATTAADATTTTAETLSEDLAKLLANLKGESQQVLHVYSYNSQTRVIKEKACIPFKNGDTTKMRLSDVRELLVSEKILEPRLLWSTFCNQRGAKVLDTTSFQSYLDILNEKSSEAGEIEVDNADIYRVYLKSEKVVDQDFLRDVLQRGGGKATVDNKIAGVPTAEQPKPAELPTSFSHNIFINPTTTFSIVHAADMSEKHWSVVLRNNSLLNAYQVVEVDEKVGKVVERSMHTAFVLKPRLFLNYQISVSAASDYVAKQKQMLRVPRFRIEDDSYIEQFEKTKAVSRAIAQSSLSQVAAEMAVGGGAFGFSASASASYAEDNSSSSASSSSEDTRVMTITYNFPRVVIDLDHHSLDLTEECKADLLSVKSSADISSFKDKYGRFFPTRVQLGGRLHASEDSTATTSTAKADQAKAMRSAAALSFSSPYVQASAKMSADKSSTSSSDESSSAATKSICWEAKGGDTLLCNDPTAWAYTVGSFYNWRAVKQSRVLAVEDVISTIPGYQYIKQKFADILKSEQPVLTTVSVGFQIGYAANSKLLTVNPSVAEAEDFSLSYETSIVAGAGAVAMTAERYDYLQKLNSVTSYALPTGLIASDKSDSQKFYVNVETVQGNEVKQLKYNHPYHIYNNSDDKTTSWLISTPSLQGYISTSLIYVGKSHLATSFQFRSTTVGDKSEYIKSGSTVYITMLDHYGAEIGSASYQPSMGDRVGVDYNNYGHTQAHIFTVTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSW6</accession>
    <name>A0A317WSW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_534197</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468340.1">
        <property type="nucleotide sequence ID" value="XM_025611484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSW6"/>
    <dbReference type="STRING" id="1450535.A0A317WSW6"/>
    <dbReference type="GeneID" id="37113627"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1620:FF:000002">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001315">
        <property type="entry name" value="CARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50209">
        <property type="entry name" value="CARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CARD" evidence="13">
        <location>
            <begin position="160"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="267"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="406"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="694"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="849"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="980"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY89429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1199" mass="137939" checksum="1A1ACAFEC538EA0F" modified="2018-10-10" version="1">MYVKQIIIQGFKSYKDQTVIEPFSPKHNVIVGRNGSGKSNFFAAIRFVLSDAYTHLGREERQALLHEGSGSAVMSAYVEIIFDNSDDRFPTGKPEVVLRRTIGLKKDEYTLDRKNATKSDVMNLLESAGFSRSNPYYIVPQGRVTALTNMKDSERLNLLKEVAGTQVYEARRAESLKIMHETNNKRTKIDELLDFINERLAELEEEKDELRNYQDKDKERRCLEYTIYSREQQEISSFLDSLEEQRQTGVEDTDLNRDRFIQGEKEMAQIDAEIAECKQQIEFLKVDKAQLEDERREASKTLAQVELQAKSLSDNQVAAQASKWRRDEDLKAVQSAIQERETELQELMPQFNAAKGQEDAVKTQLTEAETARQRLYAKQGRNSRFRNKSERDKWLQAEIRDNYASISNVQGVMAQTQEDIKDIENEIALLEPETERLRKQIDGRGDTIHSVEQQVQAAKDERDRLMDQRKELWREEAKLDSILSNASNEVERAERNLSQMMDHNTSRGIAAVRRIKRQHNLEGVYGTLAELFEVSDRYRTSVEVTAGQSLFHYVVDTDETATKVLEILQHEKAGRVTFMPLNRLRSKPINMPRASDTIPMIEKLQYDGKYEKAFNHVFGKTIICPNLQVASQYARSHGVNAITPEGDRSDKRGALTGGFHDSRQSRLDAVKNLTRWRDEYESKKNRGIDIRKELEKLDQLITRSVGELQKLEQQRHQVQNSSGPMRQELRAKRDLLQKKNDDLEAKRRAIRNIESNLAALTDQVSAFEGELSSTFQKALSNEEEARLETLNNTAQDLRRQYQELSSQRSELEARKSVLEVELRENLNPRLDQLVSQDIDMADDDKVGNLKETQREMKRLHKALEKLGQRLQQVDDSIEQANGRVGDLQQRNAETRRELEELAKSIEKHQRRMEKSMQKKAALTKQAAECAANIRDLGVLPDEAFTKYKNTDSNAVVKKLHKVNEGLKKYSHVNKKAFEQYNSFTKQRETLTSRREELEASEKSIEDLINVLDQRKDEAIERTFKQVSREFANVFEKLVPAGRGRLIIQRKTDRALRQGDELESEDEETRESVENYVGVGISVSFNSKHDEQQRIQQLSGGQKSLCALALVFAIQACDPAPFYLFDEIDANLDAQYRTAVAQMLKSISDSTNGQFICTTFRPEMLHVAEKCYGVSFRQKASTIDVVSREEALKFVEEQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WU39</accession>
    <name>A0A317WU39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_534574</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468049.1">
        <property type="nucleotide sequence ID" value="XM_025611580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WU39"/>
    <dbReference type="STRING" id="1450535.A0A317WU39"/>
    <dbReference type="GeneID" id="37113723"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY88687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="197" mass="22133" checksum="F7094C5E50BB17C9" modified="2018-10-10" version="1">MAVFMGLIIPLPFTVKRKLFAFISESPIVAKLQYGLKITFIFILILFIDSVNRVYRVQLELASFGKEGGSMGAAALGTDRMEVQARKFYSQRNMYLCGFTLFLSLILNRTYTMILDVLRLEDRVRLLEGDKKAGGKDSARLAQAGDAGEIGSLKQELEAKNRDIETLKKQCEGLTREYHKLGDQVSGEKDEAPKKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WU55</accession>
    <name>A0A317WU55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_623786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468069.1">
        <property type="nucleotide sequence ID" value="XM_025617172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WU55"/>
    <dbReference type="GeneID" id="37119315"/>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="721" mass="82609" checksum="91FE215E59B2368B" modified="2018-10-10" version="1">MASIAPAISKLNIAPAPVVANSCLEVNNGKDLTSSDPKFQVVVKLPTQSTTTHNPPRRVIPRPPLPLYTPPRQRNNQRQNRGQTFLTRQRRALGCEYQSQRKVAHSFPTPLFSYASNELSEARPSTFAQSVDQTGSGSPAGKEPSQAASPNKQKHNMSSSDESDDIVLRDFRTKSKQRNVENALPHISESGDKDIPPGGNSHDPRDEPAAERKRVPTRAEIRAELEKLKKEELANFNKRQEETEVETADPAVLAKCRDGPGVDPDSKVYQDIAKRRRVRPVVETKPSSRPESSGEESPEDDNLEQLEELKANYDWEKLLPQWDAYRNDLVMYPNVINGEVTLASEPTEAQRELQAKFLLYDRHPHASQNVNKLPPFPESLEWQPDSHLCNWFYVPPEMYHVDKWKLKFRRFLDYTIVMSCYADNYHKSFWDGTAHPDGINTFFIPKLPDHTTILDPNDEQGLLHRSETAEGYCKNLAMHTKKEEEDEEQRLLRVRRANEAFLASREVNPNAPKVNIYLRPAEMRDVPQLLLIYNWYARESSFSIHTRDVTPDYIRERIQAAKAAQLPFIVAVERSNYRQREAIFGYATASEYISGPDTAGKFTAQLEVFVLPQQQRKGVGYCLLDKLLQICDPMYMSKEGYTFDNRGMGGYSLGGQRVLARLIFCVSIKPEDRAVYRWTRDWLEKYGFELQGQLKGAACKFERLLDVYYFVRNTTFVLNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWB3</accession>
    <name>A0A317WWB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_36312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468368.1">
        <property type="nucleotide sequence ID" value="XM_025607179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWB3"/>
    <dbReference type="STRING" id="1450535.A0A317WWB3"/>
    <dbReference type="GeneID" id="37109322"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="499" mass="55759" checksum="DC977DE49D4BBE2F" modified="2018-10-10" version="1">MTFRDSSSQTLSPMDHTVPKVYFTFYHSFLLDNPQTGVESIQKGLTTLIQHLPFLAKDVAPCYDEKHENVHCIQPPSAASQSIPMLRIRYHLNESIRVMTNTATCTAVEDLQFSRRYAPLPSVMDPHKSQPLLRFVANIMIDGIILSLSFNHMGADGTGIGEVLEILSQCCRNEYNPLSHHRLELQLRRQLSSPSIAGKQPLKSFSETYSEEETFHCVAPDTWPTAVTSMAAVLNTFRFKFTSQKAKILKDACTSILSQTEDASSKANPPFVSSNDVLTALLTICLQQSQCTTEHKEDYTVASVANVRSRMDPPWPDHYLGVMLTMALVTRSSMADLVDEQKASIAAEELGIDKDELVQITNLAANMRQKLLAIDGQYVRGLLAYMQQQRDWGEMKIKGGDVSYSSIRHLKVYDLDFGPSLGKIADFRLYFALLDEFCLILPAAPGGDWDMQISLSPSHQQALMNNELFRWALSEYSSAPTRDKETDHVRLPIAAVGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWH2</accession>
    <name>A0A317WWH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_545758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468022.1">
        <property type="nucleotide sequence ID" value="XM_025613257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWH2"/>
    <dbReference type="STRING" id="1450535.A0A317WWH2"/>
    <dbReference type="GeneID" id="37115400"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY88660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="361" mass="39334" checksum="9653CF3358B61468" modified="2018-10-10" version="1">MHTLKATASSSLSLAEGHYIYSIAPSSPGSFAAISSDDSLRVFDANGLSHASVVAASAHEGVTSLKSYDAGQHVLATAGRDGKVKLWDLRSGRKSAAVEMETSKQAPVLSVACCPETNGIVAGTELVSFQAIVAFWDTRSPGQTSLQYVESHNDDVTELQYHPVRRNLVLSGSTDGLVNIYNTTIADEDDALVQVINHGSVHHAGFLGERTIYALSHDEDFSIHPATDPDEPTQEPEPVQFGDLRQPLGCEYIAQLCVGSQGPYIAAGNKQENRLDLVPLVSTPSWRFDQDNMWRLPGAHGEEIVRSVYLDEQSQSVFTCGEDGFVRAWKPDSEDQGTAQTEAKVPRKDKKNKERGRYKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWN6</accession>
    <name>A0A317WWN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468833.1">
        <property type="nucleotide sequence ID" value="XM_025611430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWN6"/>
    <dbReference type="STRING" id="1450535.A0A317WWN6"/>
    <dbReference type="GeneID" id="37113573"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="64" mass="6690" checksum="62F3F954F75F27CE" modified="2018-10-10" version="1">MEEINIPSPSAILGTHRPSTSAGGLSRSSVSPQKPTVGQPGTARDQSKPKQSKSRNGTVSLLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWX5</accession>
    <name>A0A317WWX5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cholesterol oxidase</fullName>
            <ecNumber evidence="13">1.1.3.6</ecNumber>
            <ecNumber evidence="11">5.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Cholesterol isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_515685</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid metabolism; cholesterol degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.6" evidence="13"/>
    <dbReference type="EC" id="5.3.3.1" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468102.1">
        <property type="nucleotide sequence ID" value="XM_025609927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWX5"/>
    <dbReference type="STRING" id="1450535.A0A317WWX5"/>
    <dbReference type="GeneID" id="37112070"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016995">
        <property type="term" value="F:cholesterol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004769">
        <property type="term" value="F:steroid Delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008203">
        <property type="term" value="P:cholesterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052542">
        <property type="entry name" value="Cholesterol_Oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470">
        <property type="entry name" value="CHOLESTEROL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47470:SF1">
        <property type="entry name" value="FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0153">Cholesterol metabolism</keyword>
    <keyword evidence="5 16" id="KW-0274">FAD</keyword>
    <keyword evidence="4 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="18">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY88740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1262" mass="139736" checksum="E3A5FE0C498AAA8C" modified="2018-10-10" version="1">MDGPTAAQDRIRGTNRSVNGVDGIHPRQNGGPSHDKAPSEEPRVYSTNGTEERPQFQRRFPRISLPVELMQDSYDVVAIGSGYGGGVAASRMARGGQSVCVLERGRERWPGEFPEKLEDAVKELHVSGQFAPGDRRSIPGAMVDTGNSNGLYHFVVGEGQNVYMGNGLGGTSLLNANVFLEAHKKVLEMGVWPDELRGHDSWKKYYDRAKSVLEPVQYPLTFPKLLKADLLKKQSELMSWGDNFYRVPQTTRFEDGPNGTGVYMQASQLTGMDATGINDGSKSTTLVNYLSDAWNWGAEIFCDCEVRYVTKAPNREGYIVYFAWRSCGRDRFTTFFEDLMWVHAKKFVFFGAGSIGTTEILLRSRQMGLDLSDDLGTEMSGNGDMLGFGYNTDYEANCIARPESTPDRPVGPCITSVLDLRDQKNPLDGFVVEDCAVPYALAPLMFAMLEYLPDMRRPMYSPVEKIAKLVTRMKGKLLGPYFSEGSVQKTAVYLIMSHDSSQGRLTLQNDKPMLTYSGVGRSKSVSRIHDLLEKMTAAVGGNFIANPVWSTLGRQEITVHPIGGARISKDNSGNNGVVNHMGELLRGNGREAYEGLVVCDSSALPAAVGVNPFATITAFAERSVEMMAQRRNISIDYDTRNGQLDMFNSPAFPSLRDADTTKLAARLATEHQTAGVVFSEIMTGFIYTGHDVKDFEVATRLARGRCENARFFLSVKSWSTEELVNSSQHLANLTGTFTCNALGGNFMAHRGTFQLFNHDSREPDTANLTYNFDMTSPSGRRLHFNGYKTVNTASFLNPLELWRQTSTLYVTITDKDSAVVGRGMLRIQPNDFGYELQTFSTSGASLWTRARSAASFLAYFTRQLSVPFLSTLGQLQWPGTTLDYTSKEVGPSSTIPLTASDGITTRMVMWNPISPEGREILGPAPTLLLIPGAAVDHKMFALPTIERNAVEFFRDLGYRTYCITHRVGRTPVARDGYTPYDARRDIHAALAHMRKVASTINPNEPPKTYVVAHCAGSLALACGLLDGTIPGDWIQGITASMVFMNPKFGKVDSLLSGFPTSLYARLVSPYWDCTSSRNDTYIQSFLNQALRLYPGGDARESCRSVVCHRSELVFGRLWTHKNLNDATHAQLERFLGGTSMRSLQWLMETGRLENVTANGPAYNNLATPENLDRLKGIPILFLSGTGNMVFTAENTDVSYTTLCNVHGREWYEREVFTGKGHLDAWMGSTAYQDVYPRVRRHADRIMKGEQGPAGKMDKQDGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY70</accession>
    <name>A0A317WY70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_513373</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469094.1">
        <property type="nucleotide sequence ID" value="XM_025609842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY70"/>
    <dbReference type="STRING" id="1450535.A0A317WY70"/>
    <dbReference type="GeneID" id="37111985"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY91366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="398" mass="44836" checksum="25E2C56F56C54A96" modified="2018-10-10" version="1">MNGFAAHGLNEDAFGEKSELQGGLKTFDAFPKTKSSYTAPSSRGGQWTVLILLVCTVFSFSEFRTWLRGTENHHFSVEKGVGHDLQLNLDVVIHMPCDTLDVNIQDASGDRILAGELLQRERTSWQLWMDKRNRETHGGAHEYQTLSQEDTDRISAREADSNIHHVLGEVRKNPRKKFPKGPKLRRGDKVDSCRIYGSLEGNKVQGDFHITARGHGYRDLGEHLDHSVFNFSHMVTELSFGPHYPTLLNPLDKTIASTESHYYKYQYFLSVVPTIYSKGSRALDTYANAPPSQLTHRNNKNLVFTNQYAATTQAGDLPESPFFVPGIFFKYNIEPVLLMISEERTSFLSLLIRLVNTVSGVMVTGGWLYQISGWVGELVNRKRGRGKSEGVLTGKHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY92</accession>
    <name>A0A317WY92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear distribution protein RO10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_390397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469114.1">
        <property type="nucleotide sequence ID" value="XM_025607318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY92"/>
    <dbReference type="GeneID" id="37109461"/>
    <dbReference type="OrthoDB" id="5403729at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061640">
        <property type="term" value="P:cytoskeleton-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009991">
        <property type="entry name" value="DCTN3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07426">
        <property type="entry name" value="Dynactin_p22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24036" checksum="CB2051FAEB26EDB9" modified="2018-10-10" version="1">MTLENGTVAGATIELLETRLRRLTYLLTGDANWTGNPTPPAKPASLDDSVSRRLLRLERELERLSRNIPAVRDVLSLHDRFPDLFRPTPPKSLPENLSTQNLASVVLSYASAFPETASRLTSLNDLPIPDAETSASLIQLQPRLDQLAQTQEEQAKKISELRVRSARLLQRWYEVALVSGGDCWAEWEGRLEDVEREVKREEVVRERRAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYH1</accession>
    <name>A0A317WYH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469184.1">
        <property type="nucleotide sequence ID" value="XM_025611362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYH1"/>
    <dbReference type="GeneID" id="37113505"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="84" mass="9978" checksum="4A0F3E256C15C890" modified="2018-10-10" version="1" fragment="single">KEFSRKEKKREGKKGKNPRKDGMDGGVCESEREKWRGYRRGNARGKRKPKRDENRTTNTFWNSSHSPKSKVRKEVYKTNPVPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYP6</accession>
    <name>A0A317WYP6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_463026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468840.1">
        <property type="nucleotide sequence ID" value="XM_025608000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYP6"/>
    <dbReference type="STRING" id="1450535.A0A317WYP6"/>
    <dbReference type="GeneID" id="37110143"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY90462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="185" mass="20351" checksum="C6233F2CA1EC1EF1" modified="2018-10-10" version="1">MSTSSSMSMSSMSSMSMSMVFTNSHTTPLFSSQWAPSSSGTYAGTCIFLIILAIIGRCLVAFKALLERRWLDAHLNRRYVAIAGKSTEAGRIEADPDAKAASLVTAQGVEEKVKVVRKLSHQPLPWRFSVDLPRAIMYLFITGVSYLLMLAVMTMNVGYFCSVLAGAFLGELAVGRFVQWNEHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZH7</accession>
    <name>A0A317WZH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">E3 ubiquitin ligase complex SCF subunit sconC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongin-C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sulfur controller C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Sulfur metabolite repression control protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_461231</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469471.1">
        <property type="nucleotide sequence ID" value="XM_025607916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZH7"/>
    <dbReference type="STRING" id="1450535.A0A317WZH7"/>
    <dbReference type="GeneID" id="37110059"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="10">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY91743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="104" mass="11645" checksum="FE5E7A5DDDE8A96A" modified="2018-10-10" version="1">MSASRLSQSEYVTLVSGDGFEFVIPRSTACVSGTIRRMLEPSSRFSESVTGRCVLENISGVVLEKVCEYFCYNQKNKNQTYVPDMDIPPELCLELLMAADYLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZX4</accession>
    <name>A0A317WZX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proteasome regulatory particle subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_533388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469674.1">
        <property type="nucleotide sequence ID" value="XM_025611318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZX4"/>
    <dbReference type="STRING" id="1450535.A0A317WZX4"/>
    <dbReference type="GeneID" id="37113461"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000013">
        <property type="entry name" value="Proteasome regulatory particle subunit (RpnG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000021">
        <property type="entry name" value="Putative proteasome regulatory particle subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="225"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY91946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="488" mass="54258" checksum="3A95D010D7816A34" modified="2018-10-10" version="1">MGSDPQYIKYPDLTLAQHVFNLSNPASPQAVRQTSLKKLQDVISENKMAPFYRHLAHPVEGILNHSGEGVPQLPAKSLLTSNMLASRKSPQKIDFPWDEALYQSLVEDNRKELDAFQKEEDEAEEAAGETEVLAARGKRAEFWARVGDKDKAIESHEALLEKTTFLGTKIDLMLAMVRIGLFFGDSQFVKKSIERANTFIESGGDWDRRNRLKAYKGLHLLTVRSYNLAAPLLLDSLSTFTSYELCSYSSLVIYSILAGSLSLKRVDFKAKVVDAPEIKAILGPGQDRLAALTGQISSGPGAQDEEMKDASVSRTTPAAATTVVNLTTFGAGSGIQAEAETPVDFSPLGNLVDSLYTGNYRSFFLALAAVEDNFLNQDRYLHEHRAWFVREMRLRAYQQLLQSYRVVGLNSMASDFGVTVDYLDRDLAKFIASNRISCTIDRVNGIIETNRPDDKNKQYADVVKHGDALITKLQKYGQAVRLRGSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1H1</accession>
    <name>A0A317X1H1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_623181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468768.1">
        <property type="nucleotide sequence ID" value="XM_025617134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1H1"/>
    <dbReference type="STRING" id="1450535.A0A317X1H1"/>
    <dbReference type="GeneID" id="37119277"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF166">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY90390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="289" mass="33104" checksum="6D21B2F75054276B" modified="2018-10-10" version="1">MFCCPCLVYFMSDTLLCSVWGNAAVYYAPNMSPNQKKHLRIGTQIGYAGQYIYATYLWAQKGVVLCFIERLLGLLPWPYIWIRVSWAILIVTFIAIELVYLTVCIPAYLYWQIEPAPDSCAREFYPIDNFLIMDCITDAMLLVLPFYWLFKVRQPLGQRLWILAPFSIGIFLIAVTSIRLWNYSGLLDPSFQVLLNPIEELFSAIVANVPTLWSLRRARQPAPPPIPMHPPPKRVPRALNSILITETTDVEHYVLEEPMQSTNTIEESLGDESDGHLVRSNQKEGHSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X390</accession>
    <name>A0A317X390_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_511936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469787.1">
        <property type="nucleotide sequence ID" value="XM_025609785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X390"/>
    <dbReference type="STRING" id="1450535.A0A317X390"/>
    <dbReference type="GeneID" id="37111928"/>
    <dbReference type="OrthoDB" id="4220372at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="484" mass="54127" checksum="E694F735533EDF1A" modified="2018-10-10" version="1">MSSSNNIRTRASRSCGNCRAVKRRCDQQVPHCGQCTRLRESCPGYRDEWELVFRDQTDRTIKRSKEKRAMQMTTKRSTPPPRGLETNVDQLGVNYFLHNFITSAQSPSRGWLNYIPAVFSADAEHPTLLTSMAAVGLMALANASRQPGLVKHARVKYSEAITSVNAALASPVECVKDSILMSVISLGVFEYVSNFESWVRHVQGAATLAIARGRRQFSTRVGILMFNQLRADLIIACIQANQPFPEGIRELQKEAAKHTNTQSGFWLSGVVATRVPTLMYNVGRNRGEVPWCSLLEEAMLLQRDCECVLGILAIEEPYTTIRDFEADPDLVHDSRFDLYRSAWAIRVWNNARCIEMIVCRIIIYLLQKMLATDLAPPILNGQFQETQQLLSKLGDDVLATAPQVLEFLSSGPERTVTFNSSAHASVSGGYILVWPLTMVGRCPVTKSDSRKWIIRRLRDIGESSGISMALQLLEDVVKIDELAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3I7</accession>
    <name>A0A317X3I7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_616007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469894.1">
        <property type="nucleotide sequence ID" value="XM_025616790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3I7"/>
    <dbReference type="STRING" id="1450535.A0A317X3I7"/>
    <dbReference type="GeneID" id="37118933"/>
    <dbReference type="OrthoDB" id="408743at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF21">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="2">
        <location>
            <begin position="53"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="365" mass="40621" checksum="1D4712674D46C3EB" modified="2018-10-10" version="1" fragment="single">MTLTFQPFDVPGAQLVYGHAFPYGLEVHRPDGVSSDVTTVDDAVTTLTALAESGRLSELLQQHGAVLVHGVGHPSAETFARLINAAERGRGSHPFVQIGLAGKRTLVAENIWTANEGPSDRRFYQHNEYSRYTRFPANIHFYCQNKAPHGGETPIAHSALVYERLQEAVPALVRDVHQRGLAMKMIFRAPGHEGQGNEFNWAGEHSFGQEFEPDDDRETQKAKVEVQVRKLTPTFRWLPDDALELTQHIPGIRRSPASGRPVWFNGLVGRYGMTRDLGALEPPYLGRDGMTYLPCDYGDGTVIPSEYLQQLEEVVDGLEINLCLEEGDLLLVDNHQVSHGRKPWVGDRRILVSMWDGGQAPIDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3L9</accession>
    <name>A0A317X3L9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase synthesis protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_584178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion inner membrane</location>
            <topology evidence="2 8">Peripheral membrane protein</topology>
            <orientation evidence="2 8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the ATP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469296.1">
        <property type="nucleotide sequence ID" value="XM_025615607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3L9"/>
    <dbReference type="STRING" id="1450535.A0A317X3L9"/>
    <dbReference type="GeneID" id="37117750"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000044">
        <property type="entry name" value="ATPase synthesis protein 25, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY91568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="314" mass="34999" checksum="64DEC5F769FF5F98" modified="2018-10-10" version="1">MNRLFLRGSWCHKQLLRVPSSIPSPVAFRPTLHYVNRPFASVSRLQSERPSSPSSSEAPTASLEETTSTPASDNSSHIPWYLQEETPLAESRQILSPDQIPELPENSPAILPALLEYVFKDLGLDALKLLDLRTLETPPALGANVIMLIGTARSVKHLNVSADRLCRWLRSTYKLSPYADGLLGRNELKIKLRRKARRARLASRSGTMFDEKDDGITTGWICVNAGVVEEAPLQERQDYSFEGFGHTAPGTRVVVQIFTEEKRGEVDLEGLWKNRAEREKRKYGQVEPSVPSEETSSESSAPAEEAASYRPSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3N9</accession>
    <name>A0A317X3N9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_564327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469990.1">
        <property type="nucleotide sequence ID" value="XM_025614412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3N9"/>
    <dbReference type="STRING" id="1450535.A0A317X3N9"/>
    <dbReference type="GeneID" id="37116555"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF5">
        <property type="entry name" value="DEPENDENT EPIMERASE_DEHYDRATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="320" mass="34246" checksum="D7A1A30FAB3CB17B" modified="2018-10-10" version="1">MTPQTQPPKQTKTLFLTGGSGFIGTALIPLAITDHNYTVRALSRTPSSDTKLTSLGAIPIRGDLTSHALLREETRTADAIIHLATAYQFGVHASYDEVKDIDMAAVDAIFQGLHDSTPAEKPFVITSGTLIVVPDPTGNETDETSPLDPNPINSRGELERYVLEKGAEEQGVRAISIRLAPYVYGHGGSGVRRWMEMAAAMGRVMCVGGGGNRITTVHVEDAAELYLLAAERGGRGEVYNASGETGVTAREMFGAVAEIMDVAVGDIGVEEAEGKMGMVVARFLSARRELGWVSRGRGILEEIKMGSYREVVGEVKKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4G1</accession>
    <name>A0A317X4G1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">60S ribosomal protein L25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_486570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470224.1">
        <property type="nucleotide sequence ID" value="XM_025609009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4G1"/>
    <dbReference type="STRING" id="1450535.A0A317X4G1"/>
    <dbReference type="GeneID" id="37111152"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL59" evidence="2">
        <location>
            <begin position="16"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="201" mass="23046" checksum="50DDD4A3FFA6A2FA" modified="2018-10-10" version="1">MATTQASSLVNKLPARLRNFFARYPPQVYSAAVAPRPEAPETAAVDATEELPSPYTPNRDAKGFKRPDPKEFSPSRALLHSDPKHPNPFLPRKNFRTGKWSGPRVGLRRQAELVKLAIKYNVEALLPPGRKSTEFKDTRRNERGLAIKGTGIGQKVKGHKWERTMEARLEDRRKAMMEMPEMIRLWKQRGHGRGWKSWPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X530</accession>
    <name>A0A317X530_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell morphogenesis protein Sog2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_554423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470450.1">
        <property type="nucleotide sequence ID" value="XM_025613714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X530"/>
    <dbReference type="STRING" id="1450535.A0A317X530"/>
    <dbReference type="GeneID" id="37115857"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="162"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="614"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="693"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY93689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="992" mass="109990" checksum="E7D8CAF6B2625A38" modified="2018-10-10" version="1">MLSTMIRPEDAIRMPRSYRSDVDEDDASRRTPEHNMLSSSSSSSNNDGAAKGEDEITLVNGSTGDGRSSSLGKHQTGPRLLSPDETIELAQRAVENGIQETKRSLAGSEAVSDVVKPKLTIDLGHSNIVRIPETVVDTIKDEVERLSLSNNHLFHIPYRFAECSHLRYLNIRANSFREFPKGVYKLPLLEILDISRNKISHLPEEIKKLSSLRVLSVMQNRLDDLPLGISDMNKLQILKVAGNPLRGPLRRLLETSETEFAPSTMTDNEKEVAVTAELKRFLKTKQPVTALEIERNELSEGMLDTPKPVKRGVSSRFPVIPSTGDISSDPKSPSLSRPPPIPLKSHYRIASGQHSVFHSGFLPRPGARPIAGVNERNRSNSEGIIQASLAARNKRMGVIRKNTDLGTLDETRPYRNSHLRGLSYGSILRTRPIAAVCNSNSSSPSSPRERRRLKDGFVNRMSSLPEHKGEKETVEPIIECAKGILFALFQVQSNVYSLINVIKRDDARRNSLEIVFYNASTHVERLNEAIENAEHYRSDDADAARMAKEAVKRECETCIIAYTHVGIQLRNSIDKIVTNGDPRYLRSLMLMIFGSVVELRNACASLRVPLQTRKRPSVAKPSIPEIKESTGPDRFIGPTVTPTRGREQSLSTRRFRSDTTIQHPLITTTGPFQAAQNYQSAVSSPGFAPTPFSYGARSRSSSRSNHINTSVPSSLATPRSGESFPPMPSAVVPRINPLTGLDEIEEERIFEKIFYQLTSAYTAALHALPLARRQLVRCHEAAEQGHESEGIVMLWNNLIRRCRVCLEVSEALGLRLSSMKVKEPGGGMRNQREFWQLCKTFMQSFVDLVTDMREVRGMQLLPGDLVVLLRPVQRASREAGRLIDASPWSYLADMAPGNAPANIYGPPLQSQHLQHQPSVSNSSNFHINSSVSPQSIHLPATPLSAALGPAAQATVPSTPASAYSDKFFEGDVFQRAESLLSMPNQAPFFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X534</accession>
    <name>A0A317X534_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_342319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470196.1">
        <property type="nucleotide sequence ID" value="XM_025607046.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X534"/>
    <dbReference type="GeneID" id="37109189"/>
    <dbReference type="OrthoDB" id="2549237at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1631" mass="184796" checksum="25A8621DD585DE0B" modified="2018-10-10" version="1">MSDLGFRPDLFHLTLRDAASYFQSLVTVNDSEVWATKVNAALLSYVYHCGLIPHSYGVWLTVASERYPFLLRTALLDKTSRGVRLAGINSLKVALKSPAWRTQCWDAIGGASGLKRVFDHISVREVRALAKVIGGSATKDDVRSQAVEELVDLLIPGLTTDQSPVVVGRPLLHALIPLFWGCRDAFLAKALSNSHADELPVDYILQHLGKCRTNFLRRVATCDVSSHSHVRKRLLESDLLLRITRSSEPYSGSQSYRSNAPVPGVLGFGFELVRSFGLRPPDRRTEETILESYAAIIDGAIRLKADFSDVLAFLESIMTTKDRIKAGLSIWERLLAQVVRFWATAAYPEISIKNDISPAERQRELSHPSRPQPTHKTRLEAVLIEVLTAVDDEIYYFTTLSNMLRGDFRPYMESIPPEARLPLARLIFRHYCNLGFDIDSPTPSSKETALLPWSAYFILSLTEADSRRMFQRIQSSWGREIALVCDTRQAPWVNWKDDLAWFNEKLIEVDWESRNPHCENQSPLALSVVADCRLRAERARDGKERLDWAKRAIDTALMSKSVFVYREAAQWTSRFAHDPNTRQPLAQCMYSEDAALVLSIVELPHHFYPSLETLKQLIGEANSVLAYHVEAAQQMLRQPSYKNGQDLGLRQLICSVAERRINKLKRLYYLGLGDEDQLVEVLLESLVPVILNFEKAGTCKGRERLGWSGLGGVLDNMACPPRPWKGILVFLDRLAGHRDTMWTKERSQRGPKLATPKDGWPSGLPIQYLLPSEDWTSAALANEDAAPFVSVRVRDVIFSDPRTCAHQISNETQSLGLFADSLPFSIQSYVGTGSHRETRADHVWKYYRDSTPSNIGHQETFRDWFVDLARSRGLSKLRNKLRPALPLSLINFGDSSCDHVVEWDPRSTEAQEAQEAQPPPVTTLQYRFSASKEDVSLENWADRDFEPEPWKTADTDLIELWSSGDNFARYSLPSQEALVTSVLLFVEQQVEDQQSILCQAFPETSPCVRFPAVKLSSRFLSAIDDSDTAVDAAFSVLDRLLTIAPSSILYALGKSLQRSLFRLPTTSAKYLLVERCAYRIMQLIQKSDQPILAVGLGFNVIQELPDASSRHRSALTFPLGRALDHENAETMLQKFADFILGSLKKQNTADKSPVKITTIKMLAQLVALSNFISTASQINILRSLFEASGHIDVRVATCKALLRVAVTNSGNRAPYQLFKTWTHAAARPNERINTSEEDWLKAEQDGDLPEVNADRPLLSLFAEMAPEMLPSSYLEDYFQTALIPLVQELSRQHSRWMRAFIRQVGSVPEGPSVDNIGPFDDKLTEKLIDRWLLYLPKSFLLEDRISASAYLFFVQHKALNERLNSSDSPWRGTNAASHWSKFFSGNRTLHESTRLRRFLKGDLESRISNGINKEDAMEECFERAAIATRNPYRFDEDFYLRVSSKTSVREIDLLDLPNEPSLYSLGRRMVEYAESLRTEEWTQDPARSPPILPTPFQMQLYLIPYPHLHPLAEDRYEKFATYVIRLIDEHIHDPSHLANGHKLSYALVEEVKEADVCACMLAIGQNLHTTPNPRTQFIRADLAENLLDRLERYEWNSEVLCMIGEWKASPVEWVRGIGWSNDGHVENLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5B4</accession>
    <name>A0A317X5B4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_532688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470514.1">
        <property type="nucleotide sequence ID" value="XM_025611172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5B4"/>
    <dbReference type="STRING" id="1450535.A0A317X5B4"/>
    <dbReference type="GeneID" id="37113315"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="237" mass="26764" checksum="19BC340641457CEB" modified="2018-10-10" version="1">MDDQVNRLVDKIWSTQTPRHPPTTRLLIAISGIPGSGKTELALTMSNLINQRHLRHHPQLPQIATHIPMDGYHLTRSQLSAMPDPSYALARRGAAFTFDGEKFLRLVQALREEITPETQSLFAPSFDHAVKDPVDDDISIPASCRVVFFEGNYLSLDREPWRSAAGLMDELWFVEVEFGVARERLVRRHVRAGIARDEEEAGRRVDGNDLVNGREIVQGRLEVQEVVVSSYDSAWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5E1</accession>
    <name>A0A317X5E1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_532724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470544.1">
        <property type="nucleotide sequence ID" value="XM_025611181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5E1"/>
    <dbReference type="STRING" id="1450535.A0A317X5E1"/>
    <dbReference type="GeneID" id="37113324"/>
    <dbReference type="OrthoDB" id="5297881at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="580"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="664"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="737" mass="81054" checksum="DE39F242A4B25964" modified="2018-10-10" version="1">MSRPQVSIDRLTPRRVHAEPRESMNCKSCRKRKIKCNRLRPSCEACKVFQCPCIYDAVPKKRGPKTDVLEALLKRVDGLEKRLQEDSPISPTSATSPIKSLEQHLLPSASTSFQLPPPSHSFPPPPPQPQPRLPDSMLDTYFARLHGKPYWILDEPATRQRHQHGQLPAHLSMAIYALTLRYTTPNPPQGSLESARQARRLVDIDNPSIEGTQSLLLLCHTFFAYGCGKTAYMVLANAVSMTLALDLYREAPAALPAAEREMRRRLFWTVYVMDRFLTCGSKRPCLIADHSIVLRLPGAGAGSEAGECFNPVGPNIHYSPDRRKGPGGPALLVDITRILGVTHRYLAAGGVKGDSHFPWHALSNLSKIRQELDLWAAGTQDLFASIETLFGHPDSTLLLLSKLIYHLVHCLLYRPFLPIDLVELRGTGQHQSWQIEATTLCFSHANAIAELVELARHAPRIEWPALVAYCVCTAGTVHVHGVHYHGREGEVFASSADFLAREMHQLSWLRQYWAGVQHQREMLQSISACHAELVRTMAVRPVRFAPVFHLEDFLDRYPGLAVDGGHVRLVDVDQPMPLDQPDFSGRLMYPPTSSLPSQGRPSISFQPSQPSPPWPQPDLNLPEGSLGFSPGVGTSPAAFLSDTFTAPTPPAQPQYATFPFEATPGGAALTPDAPSQSSGGMGPAATGDSEKDPFLSLLEQLAENEHSQGGPSELDFFLGEGLDTIPGEIPDGIPEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X684</accession>
    <name>A0A317X684_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_485770</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470840.1">
        <property type="nucleotide sequence ID" value="XM_025608990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X684"/>
    <dbReference type="STRING" id="1450535.A0A317X684"/>
    <dbReference type="GeneID" id="37111133"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF129">
        <property type="entry name" value="ASPYRIDONES CLUSTER REGULATOR APDR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="787"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="438"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY94079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="818" mass="90737" checksum="6356BAD27B240B37" modified="2018-10-10" version="1">MTDFEPRKRRRPAKSCEQCRQRKIRCDRNVPCGPCTRARSSLGCSYRQSFRSPTPDTHQTTLRASRSSHGAVVAPSRPPISEAHGDDLTGSLIDTPFIDSGRGDASNGSSQLSAAIRDLQVRLQHLEERLADTGITQPSAASDSAIEQTLRELCSKVQSLEQRLAICPESTRTLREELSITAMPPRLHTSAKKMKLFGPTHYTHTMDKFQLVGSLEAKGPQPLCPKLRAELTAQTKDMRDLRRSVKMQQTPRLNDPVSDLRDTIPARSVCDELVQCYLRTFEGVYRILHIPSFMKEYQQFWDQPRTTATPFLMKLALVLSIGTTFRSEQGKAGTDYDTRLTQTWIYAAQWWLTGPTEKSTFNLDGLQIFCLLLLARQMGPPGPSPWLSAGTLQIATAMGLHRDSAHFPSLSPFQTEMRTRLWATVFELVLQSSLESASPLSMPFSDTKPPSNLNDADINPDLKQPPISKPNTSQTDTSLQLLLHQSFSLRAEAIQLIHSPNRIPYQQAIDLSTKLRTTCHTITAFFQSFTTTNTTPSPNSLPYPTPFHHKHLLTTLHRYILHLHFPFARESLTTPQYHFSRKLCLESALTIASYNPSTDPSAQLDDFSRLVLTARGSLRGPLNLDIISALALELTTQLEESPPPPSPDPIQTPLATLTTTARIPILQTLQHLQVQSAHVFQALKTPSLKRYIIVSALVSQIKAMEAGNRNTQTVVYDTVRECLGVCQGALREMLSSSPSSFPASSSAGIMMTPADSGASGAGIDAMGVEVDLGLGTGVDLTVSNMPLIFIILFAVFRFPLLVWGFEYLLWKSGLIYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6G9</accession>
    <name>A0A317X6G9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_459114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470934.1">
        <property type="nucleotide sequence ID" value="XM_025607827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6G9"/>
    <dbReference type="STRING" id="1450535.A0A317X6G9"/>
    <dbReference type="GeneID" id="37109970"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="1">
        <location>
            <begin position="16"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="333" mass="36717" checksum="585A254BAB792F3D" modified="2018-10-10" version="1">MPNTLKRRLYHEAYTVALLCPLEVELSAARYMLDEEHERLQGNKQDLNTYILGSLSGHNVVLASLPKGSQGTVSAAAVAIHLLRSFPAVDLRLLVGIGGGIPSNANDVRLGDVVVSAPEGTLGGVVVYDLGKETTSGFKRKGMLCPPPIEWRGMMTSMESDHRIRSNRIAEFLSDMLQKYLGLEEYRRPPPEADILFPSEYIHVHDGMTCASCDKTKAVQRVRRTPSDESHVFYGFIASGNRVMKDGEKRDRLARESGGAICCEMEAAGLMNQFQCVVIRGIADYCDSHKNDAWHAYAAAAAAALAKEILLYMEPRCMCYAHLSRRVNKAAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7F9</accession>
    <name>A0A317X7F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470248.1">
        <property type="nucleotide sequence ID" value="XM_025611115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7F9"/>
    <dbReference type="STRING" id="1450535.A0A317X7F9"/>
    <dbReference type="GeneID" id="37113258"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF105">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G08790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="279" mass="30425" checksum="B5A9BA7DBCE95C53" modified="2018-10-10" version="1">MSCPDCFSGHVHDGTPKGEVTTLHGLDVYVTEPSGGAEAVKGIVIIIPDAFGWEFVNNRILADHYAEKGKYRVYLPDFMKGHAAPVWALYTLASVMKTGSLVDWVTKPYHVFWTAYAIVPFLYHNNFGRSWPVVKSFFTAVRQNEGAKLPIAAAGFCWGGLHTVYLAHGEEVDGKPLINAGFTGHPSNLAIPGDIEKIKIPVSFAMAELDNMVPLPQIKQIEGVLDKNGGVGEVKIYYGAGHGFCVRADVMVKNVGAQAGDAEDQAIEWFNRHFAGVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X815</accession>
    <name>A0A317X815_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_582133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471504.1">
        <property type="nucleotide sequence ID" value="XM_025615457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X815"/>
    <dbReference type="STRING" id="1450535.A0A317X815"/>
    <dbReference type="GeneID" id="37117600"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF44">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="650" mass="71810" checksum="FA8338E8942F3207" modified="2018-10-10" version="1">MSEQRPLPRNRLKSRTGCLRCKQRRVKCDETLPHCSQCTRRGFDCPGYKRPLKWSSKYEIGTSGTDARGTNPHSSSRIESISVIDVDALRIPSPFSIPWGSTASTQPDGSNLEDLSATGPDESLTISHFSTGQRQNNVSPEDEPNVDPTNDPLDMQLPEERLSHDLDDATNWVEWAQFPLPLSLPPPLGDGESGILRHYFVQVCRINSCFDSAVNFFRADIGDLMASSPLIYHCVLSMSAAHLAALKANLVATALDHRARALACLKSEMMRLKDGIESNSLTTVKTSEALLGSILLGMTDGWHNPSSLGTTHLHGARILFKRWMSSAQDDLIVPFTLDSSLRVRSFMAGFMAYWEAMASFLINQSVDATAYLNLVCDQKTPPKLHPNPWTGICTPLFVHLARVGTLVRQQSLLKQLSSVTSREDAADQLKADILRSARETETALLNYNIPTEEVIEDTADPLTPVQDLQRLAQVYRLAALLELYRNYPELLEGDAEETTGAEPAPAEKITSMAVSTLTLIAATPQTSGVNCLLTIPLIIAGSTLQWTPKRPVRRGSVKHAWSTLCGEIVAISSHADVQMYWRDFVRTRLEAVLRHVGIVAILRATEILDKVWTRSDAQTAIGCPGRGAESQQFVQWIEVMVEEKLETVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9S5</accession>
    <name>A0A317X9S5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CENP-S associating centromere protein X-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_531255</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-X/MHF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472097.1">
        <property type="nucleotide sequence ID" value="XM_025610857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9S5"/>
    <dbReference type="GeneID" id="37113000"/>
    <dbReference type="OrthoDB" id="2500381at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22921">
        <property type="entry name" value="HFD_CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018552">
        <property type="entry name" value="CENP-X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28680:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09415">
        <property type="entry name" value="CENP-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY95336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23463" checksum="6242502860B3E055" modified="2018-10-10" version="1">MPAERKTALKRRQLPFKPPSRTSASASASVSTSAPAPAPTSPPPPAASKPKPKPKSKPTTKPKPRAPKSSAPSTTTSKPARPSTKSKGKAPVSAPASDNESDSSSSTSSSPSASPEPEPDYILAEIIHNETKSDSVLTNDPVIPPKLLTRLLHHHFQNQKTKIAKDANTVVAKYVDVFVREALARAAFERREAVGKGVSVGDGFLEVEDLEKMAPQLVMDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9W0</accession>
    <name>A0A317X9W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_484027</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472050.1">
        <property type="nucleotide sequence ID" value="XM_025608943.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X9W0"/>
    <dbReference type="GeneID" id="37111086"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="903"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="950"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="304"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="631"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="915"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1233"/>
            <end position="1472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY95289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1489" mass="165061" checksum="D2D5345C5B15AAB7" modified="2018-10-10" version="1">MEPLVAIVPAAMVSLTTQGGAGEIGHIPDPGLVQREIWQYRTRKASAFVGAGNLHLAALLSSWVVILLSISVHYVRHHRTKSRAPKSSPHGQSEIVISLPFAFAHLAAATAACCLAWIDIHLGGSWKRSLFLTYVVLLGIVRLCCKSYGCRRHMYWHMNAMAVGALVLAVVQDIAPMTVIGATYRPSSVGAAIVACLAAVVAVALATPRPRRALVHDTETDELVEAKVSPEETCSLFSYYCSYEWITYVILRGCQRDLTLDDLPPLPTYDEPLKWLEKIKRQRLKGGKTFRTLCRMLKTEIKTMMFWAAFTAVVDFLAPYSMLRLLAYLENPRSAVLHPALWIALLFVGPATRSLCYQQYIFTATRLLVRVNVSLVQELYQTAMRSYIYDESVGQSDEGKQAKSRNRAESKGASKSSQANLTSLMSYDVDAIYNSRDIFYIATAGPISTTLALVFLYQMLGWPSLFGVLMLLCLSPLPAMASRKVSRIQRSVMQATDARLSKISEYLQSIRTLKYFGWEHAAMSSINDVRRVEQRRLWRRSVFVALISMAGELLPLLSLLVMFSVYILFTDLPLRAPVAFTSLSIMETLRVQFIWLSNISRYAAQGSESLRRVDRFFDTASEIQRHPEGPLEFKDATFRRTPIAAFRLQNLSLRFKPNALNVVTGPTGCGKTSLLLSFLGETVLESGTATCPRDVAYVPQAPWLQNDTIRQNIIFYSLFDEARYAMVIEASGLAQDLRQLPAGDSTMVGERGTSLSGGQKQRVSLARALYSPSSTLLLDDIFSALDTHTTSLVYEKCFRSGLLKDRTVVLITHYPAAMQDAELVIRLEHGKIVPVRAFKTQSLSQSPSTTPGTDTDSSVAVPVTETLDAPSEGPTAEPPAVETRIAKETSATGRVPRTLALRYMLLFGGPSYVPLVVVATISVQFAYFAITYWLSIWTGAYEKYEHPDTLFYLGVYAACILTFLSLQLCNNLIYQYGSWVAAKKTHHRLVTAVLSAPIAWFDQNPIGRAINRFGNDTRSLDTVLVEWLRMSIENMLRFLLRIASVASIMPIFALPAAVICSAGFLIGEMYTRAQVSIKRLTSVNYSPVFSHFTDSLSGLSVIRARHGMDQVFQNLLADKLAVHARSSEAQYNCNRWVSVRTDFCAASVAAAAGCVAYFWSGSAGLVGFSLTNAIGLSQTILTLVRTMNELEVELNSFQRMMEYADIEPEEKLSVEDQRKVEALPASWPTSGRVEFTDVTARYQADGPDVLRKVSFVAYPGERVGIVGRTGSGKSTLGLSLLRFVDIVGGQVTIDGVNIDQIRLNRLRTSVTLIPQEPVLFSGDVQSNLDPFGESDETELRTALSACTTINVPGEPGKGLQPLSLDTAVAANGENFSQGQRQVLSLARAMCRRSKVVLLDEATASVDHETDMHMQRVLREMFSDCTIIAIAHRLRTIMDYDRVIVMGDGQIIENDSPANLVSQRGVFWEMLRNTGEYEELIEMMGQEVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA58</accession>
    <name>A0A317XA58_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_484649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471293.1">
        <property type="nucleotide sequence ID" value="XM_025608967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA58"/>
    <dbReference type="STRING" id="1450535.A0A317XA58"/>
    <dbReference type="GeneID" id="37111110"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="594" mass="67230" checksum="24C57C754C7017A4" modified="2018-10-10" version="1">MAGQAQRQQPGLACEECRRKRIRCDRGTPQCMACATAGVNCVVRDSCPPRGPKKGYLKTLQKRIEDLQSQLEKQQRASPTETRAFSPSQEGTTDNEGGSGGSSTDHTEIQNTTSTTPETIVNLPQWPAPVEFQVPMIHMEPWGCFDASSPFPSLPSVDNLQELVQIYKEPDFIITPMMHNDLDQLYFDRAYAFAPIIQTHRYRSWSKQASKSKQKTCLQHAMWTLASSLSSQFQDDGRKLYNKTRQLLHAVESDEPSQQICLEQAQAWTLLALYELTCQDFHRGMMSAGRAFRLIQMMRLYELDVPQAPATMQLEQYQGQLTLQGPVQDDWIDIETKRRTFWLAYTIDRFTSMVDGLHMFFDERLIRTRLPAPEANFASGRPMEMSFLADMIPIVDLEWPHNNLSSFTESVIGATICGRVLEHKQKPPGRPCQEFCRRHRSLNALLAQRIRMLRLYASLEYPDPIISFVTLAAHIAVLMLYDLIESRPLGTDPQGTQLTQALYTEHKQQSLDSVADIAVLIAVLGQHFQMHPLTPILLLLAARFSQSHPGLNDAYIKLMPSIVTTLQASTGLNKLAQNFLSLLEPQGDNWCALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAW1</accession>
    <name>A0A317XAW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_454980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472484.1">
        <property type="nucleotide sequence ID" value="XM_025607626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAW1"/>
    <dbReference type="STRING" id="1450535.A0A317XAW1"/>
    <dbReference type="GeneID" id="37109769"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY95723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="89" mass="9577" checksum="6FF46F173A4A6CD1" modified="2018-10-10" version="1" fragment="single">LGPIVGSAMLLVATAIFLYYTTWTLLMPFVDPGHPLHDLFPPRVWAIRIPVFLTLLGSAVVGTFIGIVMINSNKKKAAKAKAAAAKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAY2</accession>
    <name>A0A317XAY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_456393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GSE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472102.1">
        <property type="nucleotide sequence ID" value="XM_025607697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAY2"/>
    <dbReference type="STRING" id="1450535.A0A317XAY2"/>
    <dbReference type="GeneID" id="37109840"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11385">
        <property type="entry name" value="RagC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000004">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000643">
        <property type="entry name" value="Small monomeric GTPase (Gtr2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039400">
        <property type="entry name" value="RagC/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="384" mass="43761" checksum="592A7002540001F4" modified="2018-10-10" version="1">MDLPRWIGPGPEGCLFGNHTQPPVKSDAQLTLENIVQGTSQSLEQPSANSGHAPANNAQDAKPRLMLMGLRRSGKSSIASVVFHKMPPNETLFLESTTRIQKDSIHSFMDFQVWDFPGQLEYLEPSFDLENIFGSLGALVWVIDAQDDYLDSVARLNRTILTVQQFYPNINIEVFIHKVDGLSDEYRTDTFQDIVQLISDELSDAGYENAPVHYYLTSIYDYSVFEAFSKVIQKLIPNLSTLENLINTLANNCGFEKTYLFDVLSKIYIASDTRPVDMSCYEMCSDYIDVIVDISELYSWDHPDRKPKGDQNQEAESHVVLHDETMIHLLEMNKYLCLVSVIRNPESKDKKGLIDMNCRTFQEALNDVFSRSWEQVQEGRVTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB98</accession>
    <name>A0A317XB98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_325694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470999.1">
        <property type="nucleotide sequence ID" value="XM_025606934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB98"/>
    <dbReference type="GeneID" id="37109077"/>
    <dbReference type="OrthoDB" id="4526793at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="116" mass="12984" checksum="FE550E02CD9D0BF9" modified="2018-10-10" version="1">MYVIIICATLPTLRQSYIVVLHRTRQTASYYTHSLSIQKPRPISFPRRMPDASLFETGVDGTGLANVASPGNTGQNDTAITKTTEIEVLEESNIGKDPENPHFPREDPFRFGSYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBA0</accession>
    <name>A0A317XBA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_571971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472152.1">
        <property type="nucleotide sequence ID" value="XM_025614898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBA0"/>
    <dbReference type="STRING" id="1450535.A0A317XBA0"/>
    <dbReference type="GeneID" id="37117041"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="21"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="93"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="716"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="721"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="753"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY95391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="805" mass="89881" checksum="C7751A5A92C0FB38" modified="2018-10-10" version="1">MPPKLGGIAKQRTSRRKIALACDACREKKIRCDGEKPVCGSCLRRSYGIAQCAYSMENSRTASQEEYIRALRSRIKELEDICLQAGVSAPDQREDASYQKDCRVNTARPSQRQRSSPQTATGDDQVRQTRPEIEQHAVEQASIMPRIGSSHQQQGANPFHEKVTNSGRATILRDGLNLNITRGRRDISEASSVSPHFDSPGHVTTMGQISTPGGALAVPTPVREYYGSSSTASLMRFARVSIPWQSSASSAGIGSAHYQFYESPNTQYRMNDFSLPPRSLADHLLDCFWEHIACIYPFFDQPTFEMAYDNLWKSKEEMNELPDIHIGLGGQFDSNPKSIVFHCALNAMFALGCHFSDIPLHEREATAHSFFLRSKRFVGLDLLEIHTVGVVQALLIVALYLQSSPYPSRCWNAIGLACRLAQGLGLHEANPSSMMPLETEVRRRTWHGCVMLDVFVSMTHGRPSMTSHLAPVPLPYSTGAVPPTMYFYMGTIKLYRILDKVLSDVYNMWRSRSSEGVKSTFWSEGSFDPLLELERQLQSFKAGLPSCLKWTTSERLDRPVESAILDRQRNILRSRYYYIRLLLYRPIFTQVCSDSSPVTNQQRNGPAWRDAESSLQSCIINKCAATCVTTAIDLVQLTYDTYLTPFTDAWWYNGFYASTCALVLIMASSVPSLSDTVNPAVIEETWKKSETVLTHMATFSQSARTSLRFLQAAFSQTAHGRPSSRPSPRDIPNPSRGSIPTHTAGAHSAADGPTSSVPPQTNTPGLDSSYWTDSDFGFGSLQDDLGLLSWIDVPDMWQWLSRPDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBS8</accession>
    <name>A0A317XBS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">50S ribosomal protein Mrp49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_531387</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471179.1">
        <property type="nucleotide sequence ID" value="XM_025610889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBS8"/>
    <dbReference type="STRING" id="1450535.A0A317XBS8"/>
    <dbReference type="GeneID" id="37113032"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="6">
        <location>
            <begin position="44"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="199" mass="22221" checksum="8891532B7E47CC94" modified="2018-10-10" version="1">MRKLKTVSLLDLQVGAGAATFPTASSATKEFPAITRLHLTYARKIYGGHQGARHFWRNCLPRLKYYNPAVPMTVRQTDQQDGPAALTIYFSERASNAATLLAGKVTDKHAPAPSSTEKTAVLDVKDLDYKDIWTKVKNMTGAQDIPASAEQQAELQKLEQMRQQGDKDRLRIAAIRQAKADQERMLQEARGEVEKLKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC03</accession>
    <name>A0A317XC03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_138735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472626.1">
        <property type="nucleotide sequence ID" value="XM_025605712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC03"/>
    <dbReference type="STRING" id="1450535.A0A317XC03"/>
    <dbReference type="GeneID" id="37107855"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="426" mass="46406" checksum="D8C6B55D04F13C9F" modified="2018-10-10" version="1">MSDLDRAIAQLRACRLIPEAQVRELCYKARELLIEEGNVVNVDAPVTICGDIHGQFHDLMELFRVGGDVPDTNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRITLIRGNHESRQITTVYGFYDECIRKYGSANVWRYCCEVFDYLALGALVLGASSELDPSGPVDTTQSTVPLDDELETEILNSKGEVTMSTYRPRPQSSGASTDSRALSPPRDIATPSQAPIRSGAAGTGASGDSGGSLSSRTGAVLCVHGGLSPVIDTVDKIRLIDRKQEVPHEGAMCDLLWSDPDEIDGWGLSPRGAGFLFGGDIVKRFNQRNDLSLVARAHQLVMEGYKEMFDGGIVTVWSAPNYCYRCGNVAAILELGEDTSNGGTVARSNGDSGRSNGLLGHNAPTVRSPGRRYRVFEAAAQDTRGMPAKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC64</accession>
    <name>A0A317XC64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_133702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472452.1">
        <property type="nucleotide sequence ID" value="XM_025605669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC64"/>
    <dbReference type="GeneID" id="37107812"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="265" mass="30402" checksum="6A49C064FD0D32EC" modified="2018-10-10" version="1">MAFSFLFLNHRFDRFRISPLHHILLWTGSESNLDQIPRTHKHSINRGISPMTMPTSVKRMSPPAWAYSEQRPGLTDPSEFWRAIEPEIDKQGFRAVSNAIYVVGGYQPAMWTGACDRPSSSWYGVPCTNDKRIYIQIRPYQSLFGNLYSVPTSLGPRHKGIPGYSQRHLSTSLLTTSIVGSTYSVIGRTYRYGVSRIRQPNDRSQRLHPPKSQGRITPTGIPRDARYLIKRLHPRRLQRDRPGWTEVGGRRNRDYRIDHEGATGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCE3</accession>
    <name>A0A317XCE3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_531281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472123.1">
        <property type="nucleotide sequence ID" value="XM_025610865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCE3"/>
    <dbReference type="STRING" id="1450535.A0A317XCE3"/>
    <dbReference type="GeneID" id="37113008"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="612"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="769" mass="86524" checksum="8E9FB286FC250403" modified="2018-10-10" version="1">MVVESNKSGMADVPLKANLPRKSAFSCEACRKRKVKCNGASPSCSRCAARGEVCVYSLAPTLSYTKQLEARVAQLEDALSKLRNQQPPESVVRKAASPASPGESSASPGIRTRIKEEEESESDLVRDFEGLKVEHDGRISFHGPTSLFQLPSGLLSETSSTIPLAMQLEGRKERLINNAWRERAFEQMATMPEPFQYLLDSHWCWIQPLFGFVYRPTFTRDMKINGPYYSDALLNAILAHSVRWCKTEPRIGPILQSFEGGAQFSHRAVSGLYDSLKAGYIGIPTIQTLLLLSAQEFGRGNRTQAWLYSGMAFRMLDDLGISIDSRKYSDSAHLSDEDIEIRNRLFWSCYFWDKLISLYFGRSPTMQHSRVSPPRMILDDTAEAEIWTPHGVVFPDGTHYPPTQAHSTSCFMKMCGLAEILNQILIHIYDPIRQVSEMEFHNCIQEQAANLADWWEELPGYLKLQPMDIPPYSPPSHIVTLNCLYHTINILLHRPVLCSKSNREAYDKSHLVQCMTSATTILSLFDLYRRTFGDSHVVLSLAYSVYTAASIFLLEIQALKYAAPGTLDKLRYCIYALERVKGTNPVITTALSLVYQELHKLQIDVHLVIPAPQPEQPQQPPQSQPQPQPQPQPQLHQRSRTHHSHSPSQHHASSPASLADNSRRVSPVQQQPQQTDHPMDPIHNTGMNSTAPIMPGYTYQQPVAEFELSQTNVPQMTTAHLLGGMPNAMLTLDNPGSYEITPEVFEAFSYAEPITTNMTPAVDYVWDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCH6</accession>
    <name>A0A317XCH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_531596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471419.1">
        <property type="nucleotide sequence ID" value="XM_025610935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCH6"/>
    <dbReference type="STRING" id="1450535.A0A317XCH6"/>
    <dbReference type="GeneID" id="37113078"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="154"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY94658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="403" mass="44313" checksum="FF655AC2C21049A7" modified="2018-10-10" version="1">MARAFAEKDAIPNDWRIRQPGLTVWILVSVVRILLVAFFYSIYYALPSLRQSPTWTYRQAFATRLTKISMTIIREVGFTQSLSLESGELGDRWVIMNPASADCYRGAFASDTIKPEKIGATWYPNPPPKASPRLVDDDDNEDEDEDDNKSVVALSFHGSAFLWLTGRPDDSGFTADLLNSALGPGARSLWVQYRLAGGDHPTPYPGPMQDTVTAYLYLVQEMGISPSRIVLVGDSSGATMAMALLRHLASFQNQAGHELADLPPPRACLLFSPSVEYSYEGDSQAVNANRNQPTDYCDGQMAAWGARAFAPPETVQLDDPYLSPSLHPFATPVPIFAQVGGAEMLCDSVKGFADAMRAIPGNRVEYLENPGLPHDIYMIGQILGWPEQQIEMIDAAAGFVRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCV2</accession>
    <name>A0A317XCV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_610330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471539.1">
        <property type="nucleotide sequence ID" value="XM_025616607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCV2"/>
    <dbReference type="GeneID" id="37118750"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF319">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="53"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="441" mass="46912" checksum="3BB810416DEF9206" modified="2018-10-10" version="1" fragment="single">MSSTAPERTPRSHDGSEQSMIFADQEPRHENVSEKGPSDEFEVGPAPDGGLRAWLVAAGAGSVFFCTLGLANSFGAFEDYYLTHQLKGDTEGAISWIGSLQSFLQFFSGMLGGPLFDRYGAKVFWPAGLLYVVALMLLSVCKTYWETMLVQGVLIGLVMGFLQIPAFAAVSQYFDKNRAGALGLAVAGSSIGGVVMPIILSKGFNGSSLGFGWTVRVVAFVILPFIGLACFAIKSRVPPRKTHFFLLAPYKQPRFVMLFVALFFMFIGMFTPMFYLTTYATTQGMSATLAGYLLSMVNAASTFGRIVPGILADKFGRLNTFAAGGIITGILVFCMTSATSNAGLIVYAIFFGFCSGAIVSGASATFSSCPDNPRDIGTYMGMGMAISGFGALVGPPINGAITARYGGYFECCMFSGSMAVFGGFIAFAAKRTTKEGLWGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDC7</accession>
    <name>A0A317XDC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_592509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473387.1">
        <property type="nucleotide sequence ID" value="XM_025616147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDC7"/>
    <dbReference type="GeneID" id="37118290"/>
    <dbReference type="OrthoDB" id="4509529at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="280" mass="31907" checksum="DEB6EF6FC69433E1" modified="2018-10-10" version="1">MLLSPDETMVLDDTIPPEDIGPLKTPPNHPTMIDDIMIEITASSTASLPHLTGPVDYELWCEALAADLRSIGYWPIISDPRPITTDPILDEPRYPPPPGTPQLELKLPQFELSLPLRFSPSYRCPRPPHNSLNDRARIMILETLSPQILAEVEHMSSAKDIWTYLDRKYYIVNPLDGIKAAMALRYDNGKSVLSYALKMQHALRKIDRAIAPGDQRVPEAMKVQFLLSGLGDEWREWLEENGREKEKEFMGMGLKEAVRVLGEKEGRSSWNWDFIKGWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDJ4</accession>
    <name>A0A317XDJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_562002</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473344.1">
        <property type="nucleotide sequence ID" value="XM_025614261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDJ4"/>
    <dbReference type="STRING" id="1450535.A0A317XDJ4"/>
    <dbReference type="GeneID" id="37116404"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000069">
        <property type="entry name" value="HAD-superfamily subfamily IIA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000124">
        <property type="entry name" value="Putative aspartyl-tRNA synthetase Dps1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="622"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="378"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY96583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="934" mass="103665" checksum="B4F10C9B5C993828" modified="2018-10-10" version="1">MRSQSLWRSFGLLQRASTRSFVDAGSGRRAFQTASSRIPDFAFAFDIDGVLLRSSKPIPGAAESLSLLKEQNIPFLLLTNGGGKHETERVAEISEKLQVSLDPELIVQSHSPFAELVRGPDEQSALENKCVLVVGGEGDRCRQVAQMYGFKNVVTPGDIYMANPSIWPFRSFKDYYENITKPLPNPKDPSDPSRGLKIDAIFVFNDPRDWALDAQIITDILLSSEGVIGTISEKNGRSDLPNRGFQQDGQPHLYFSNPDLWWAAAYHLPRLGQGGFREALEGIWAAVTGGPNKGVELKKTVIGKPYQGTYEFAERQLLRNRVRMFGSDAQQPLRNVYMIGDNPESDICGANSYRSGHGSQWHSILVRTGVYNGGEPAWKPKTIADNPEETPAAAAAPAEGAEASKSASKSAAKKAAKEKAKAEKAAARAAQEKAQAAAAEANDTAKDLYGKLPETEDVLPATRFSDITDEHYEQEITVVARVDNARVQSAKLAFLMLRQQGQKVQAVIALTEPISRQMIKYTGGLNVNSIVQVTGVVKKPAVPISSATLSNHEVHIRKVYMISEAAQMLPMQVKDAERPPPETTEEGNEVDADGTPIVTLKTRLDNRVLDLQTETSQAITWISSGVAELFSEYMIKSGSRWIFTPKLVGAATEGGSNVFEVKYFKKNAYLAQSPQLYKQMCIAGDMESVFEVAPVFRAEDSNTHRHLTEFAGLDFEKTFRGHYHEVLEFAENLLVFILTQLKERYKDQIAVIQKSYPKAGDFKLPKDGKALRLNYMDGVAMLKEAGVDVSEQERFENDFTTAMEKQLGQIIRDKYDTDFYVLDKFPMAVRPFYTKACPEDSRFSNSYDFFMRGEEIMSGAQRINDIKELEESMIAKGLNPNQEGFEDYLAAFRQGCPPHAGGGLGLNRIVMFFLGLPNVRLASLFPRDPQRLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGU0</accession>
    <name>A0A317XGU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_570570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472981.1">
        <property type="nucleotide sequence ID" value="XM_025614822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGU0"/>
    <dbReference type="STRING" id="1450535.A0A317XGU0"/>
    <dbReference type="GeneID" id="37116965"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="431" mass="48702" checksum="1B6ED7A5C942CBAF" modified="2018-10-10" version="1">MASSPFITTEHIVDCQYIREYPRATRTTEDALKLVVKKYTPKSNPNPRPGDITIIGGAGGGYPKELYEPIWEELYERLKRDGLRIRSIWIANPVGQGASAVVNEENLGNDPSWFDHSRDLLYMINQFQADMLRPLMGVAHSLGAGQLLHLSLIHPRLFSSLVLVEPVIERDFVSGKGPAFAKLALSKKDVWRSQAEATAFFKKTHKNWDSRVLDLWLQHGLKKLRPESDLAEEADSDSPVTLATSKYQEAALYARPNFLNRQMLDFEKNPDPDTPHDASFHPDVVGPTQAVFPFYRSEPKILWGALKHIRPSVLYVYGGKSPISTADRRAYKLQRTGAGFGGSGGYKNGRVKEVISPHATHQLPFEDVTTVAEATAEWMKQETAKWKEEEERIQKGWLELTTKERITLPDEWHTQLNSYSAKGKQKPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XHE1</accession>
    <name>A0A317XHE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_453890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473331.1">
        <property type="nucleotide sequence ID" value="XM_025607582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XHE1"/>
    <dbReference type="STRING" id="1450535.A0A317XHE1"/>
    <dbReference type="GeneID" id="37109725"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="310" mass="35844" checksum="D49D089ACA6B1E89" modified="2018-10-10" version="1" fragment="single">PLLELDQRLIGNKDTYAVTKKLCEYIWLARSKSDQIFLIKCAPYPQYRRIDHERRTIKKFQSQTTCLRPLLDRIKEPVDPPAIVLKYLDDDLLKASAAKWLTIPEIKYVSKKILEGLSVLHDAGYVHTDIKLNNVLVNYGLESRFTDVQISDLESASHIESQFCKSRPFIGTPIWRSPEAALGLQWGTPTDIWSFSTMLISIIWGNNFFIFNPGVSCFDEAYGVIILTKFHIYFGPFPPPYADLLDERASKMLSWIQDTITSTAMRPLLRASRREISEEDRRFDLKVMTLDPRDRPTARQLLSDEWFHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UTJ5</accession>
    <name>A0A317UTJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_591486</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000066">
        <property type="protein sequence ID" value="PWY64781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461327.1">
        <property type="nucleotide sequence ID" value="XM_025616113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UTJ5"/>
    <dbReference type="STRING" id="1450535.A0A317UTJ5"/>
    <dbReference type="GeneID" id="37118256"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY64781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="478" mass="54165" checksum="E03AB871F2C60BDB" modified="2018-10-10" version="1">MFNFIPSIDLTPFTILLTLTLLSLLLLTHHTITTLHTHPLNKYPGPLHWRLFDLPSLLSLTLGHLPHDLHTLHKHHGPVIRTSPTSLSFTSPLAWNDIYTRDRLFLRPPQLKDQPPGKTALNLIACSEEEHARLRRVLAQGFAAKAVRAQEGVVGGLIDVFEGKIDERIDGGGGKGYVDVDVVEWVNYLSFDVIGKVTWGRSFGCLDGLRYGSWIQTVRQFKAAVVVGALKYYPFLYWVVMRITPPGVLRGVMEMWRVTGERGMSVEEMEVNSMLIVAAGSESITTVITGTVNYLLREPEKMRRLVEEIRGRFGTEEEITGTRVKGLPYLDAVLSEGMRLCPTIPDGMRRLVPEGGAVVAGEFLPGGTTVSVCQWASYRDERNFCFPDEFAPERWLEEEGGKRFEGDVKSVFNPFSLGAHNCPGQNLAWLELRLILARLLWRYDLSIPPGVELPRWEEQGIWWFWDKKPTLVRFSRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWV2</accession>
    <name>A0A317UWV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="12">3.2.1.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Galacturan 1,4-alpha-galacturonidase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Poly(1,4-alpha-D-galacturonide)galacturonohydrolase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_529339</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000064">
        <property type="protein sequence ID" value="PWY65007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461358.1">
        <property type="nucleotide sequence ID" value="XM_025610458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UWV2"/>
    <dbReference type="STRING" id="1450535.A0A317UWV2"/>
    <dbReference type="GeneID" id="37112601"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000040">
        <property type="entry name" value="Probable exopolygalacturonase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF6">
        <property type="entry name" value="EXOPOLYGALACTURONASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016325701" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="18"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY65007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="446" mass="48746" checksum="0AC671645F758D0E" modified="2018-10-10" version="1">MRLLSLTALLLSAGTLSVGVAVGGLIPGAKVIPASDTAGLQAIGAQNSKYSDRQTVTIRASKNAADDISADFLWGLQRANHGGRLLLKEGEKYVIGKKLDLTFLDDIEVQLEGEIQFTNNITYWQANNFYYSFQKSITFWRWGGQDIKIFGSGVLNGNGQKWYDEFAGMQILDPDNTFYRPILFLTDNATRVSVEGITQLNSPCWTNFFVRTNDISFDNVYIHAFSTNASSDPANTDGFDSLVVDNFSATNMRIDVGDDCFSPKSNTSNIFVQNMWCNNTHGVSMGSIGQYSGEMDFIENVYIENVTLLNGQNGARLKAWAGPDVGYGRMNNITYKNIQIQNTDAPIVLDQCYFDVNSTECAEYPSAVNITNVLFENVWGTSSGKDGKVVADLVCSPDAVCTNITLTNVNLTSPSGSAEIICNDIEGGIGVDCVSDSSATKRSLYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UY16</accession>
    <name>A0A317UY16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_528621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461684.1">
        <property type="nucleotide sequence ID" value="XM_025610432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UY16"/>
    <dbReference type="STRING" id="1450535.A0A317UY16"/>
    <dbReference type="GeneID" id="37112575"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="62"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY66486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="406" mass="45527" checksum="2F6FF2E47F26B738" modified="2018-10-10" version="1">MDVGSHHHHHNGSSSNTTSGVYPKPASSINFGPELLAAVWTMSALSIVVVSLRSIGNAKFGNFQISDLVTLFALILLFIAAVLSTVAVDYGYGQTASSLELHHAMNSLKYSTISQAIVTLAATAGRLAFIVYLIELLAARKLHRIILWILVPCQVIVNVISVFLLFYQCTTHIDELFNPSESNHCMSLTVQIDYAYFQGSFNSACDLLLAIFPIYIFWHFNWNIKVKLVLISLLSLGVVAMAASLVKTLEYPGIISSTNPRTNRVTLLRWMFIEAGIVLITASIPCLRPLIILWIRKLLKRTPTRHQKMPNTNNNNVQESTQTRNTLFNMGQVTEDWKQRWIMPYTQDHASGESLERYILGNITTHIFAGDREFLDRCVPRNGIVKDVQVEVVVDEIPLTEVEEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZB3</accession>
    <name>A0A317UZB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPD-GlcNAc transporter (Mnn2-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_339828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000059">
        <property type="protein sequence ID" value="PWY65280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461405.1">
        <property type="nucleotide sequence ID" value="XM_025607032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZB3"/>
    <dbReference type="STRING" id="1450535.A0A317UZB3"/>
    <dbReference type="GeneID" id="37109175"/>
    <dbReference type="OrthoDB" id="999962at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005462">
        <property type="term" value="F:UDP-N-acetylglucosamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005464">
        <property type="term" value="F:UDP-xylose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF4">
        <property type="entry name" value="NUCLEOTIDE SUGAR TRANSPORTER SLC35B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY65280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="464" mass="49923" checksum="51EC6136C201D5CC" modified="2018-10-10" version="1">MSVPREMVQERNSILTQRNKSGTNFKLEITPISVDGTRDVDSQKTPNQLTSNDKEIGPTKATYGQLASITSAATYTALPGWTNIILMFSLIFGGCCANVFALEAIIKDQPSSGPLITFAQFLLTSLITIPGFLSLSAGPRSLYLSPRAIPLRSWLVYTLFFVTVNLLNNWAFAYKISVPLHIILRSGGPVASMGIGFLFNAKRYSRGQVLAVLMLTLGVATAALADAKAKGQSMNVENASAATTLVGFTILALAMILSAFQGIYADRLYETYGRDHWKEALFYSHTLSLPLFLPAYTQLVSQWQLLFPAHPLTARLQALNSSEIGLLGHASPGVASNSASEESCEAWSLASIISGSSGLLPILKDILPLGSIFTIIPIRVTYLLVNALTQYLCIRGVHLLSAKSSSLTVTVILNIRKLVSLLLSIYLFGNDLSPGVLIGAVFVFIGGAMYGFGARSRVKSAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZX3</accession>
    <name>A0A317UZX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_628895</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461890.1">
        <property type="nucleotide sequence ID" value="XM_025617516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZX3"/>
    <dbReference type="STRING" id="1450535.A0A317UZX3"/>
    <dbReference type="GeneID" id="37119659"/>
    <dbReference type="OrthoDB" id="5398572at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="872"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="830"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY67246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="964" mass="108389" checksum="34E7146E89E494DF" modified="2018-10-10" version="1">MARLARSREAAQSSTEHWVTSKGKAWTGSPIRRRVTRSQSRDLEGSGPQQHDDGEASMDAGRRRGGGLGKGRMGGEGLDVVSEESPLQSAPRLGQYANQVIPETPEEEANISGTTILPSEPDLDLDPDIMVEALPDLERAAGNVLDFLVPGSADPVSIISTAKKLGDPGSTQSRRLQRSVTNLNHEVKYFGLSTHSTYLDVEQIVKVSGLEDRWKPFLHKANCARFALRMLLARPGTNSSPEQTISSIQAQFPLPFMTNLVEKDVQKSVDESYLDKDTFELALEIRTQYLIMQLEAHQDDDDFDPVEILTSGFFLHLPKDATEDAERRFRGFNLERFTGLRQELPSRYRSDVEDRYNDMRVVLEVDGTLEALKGDYRWQKFVMQAVRWIRKRTDEINNDLIHMDDVYSMSKTRHSLGNTMGFSTPSSQRMENRFPVVNNSARKTVGFSDGQGPSQPLVRASPVSSQRTATPAPAPNPHTVPDIIEPETTVPRVASVPRDVLPPADTREPTSEVSDRRKSSRPSFLNKAAINRVMQRQQQLRGLTETSSSHRQSDFVRPNRPDVAQQSTSDRRQTVAAMPPRQRSVSAQPHETFDASRTLVNEDSQVNDDTQVNDDSQVNDDTEAYEETELNEETQVNDTEVYENRLNDNSTVIDETEITVNDEPLDISQHTESHPERSHSPPMNRSASRPRHAPTSSLAPPTTNNLALPSSRDVWNMAKPQAPPRLDANHSSRPAFIDRQENAVRVSPVSQASDIRSVERRPRGRPPKRRRETSSVSESDDEFDTNDRVVDTERRRAAKPVQARQSKRARVDNGHEDGRDGVEEQRRQGSQDAARSPARTQAESHQGSNQESTSPPPRRKTVSARGRQSRGWSEAEDTRLVRLIKEHGISWAKIENENLVQPEKAGETRIKDRNQVQLKDRARNLKIKFYREGLPIPENFGGVTMKRGDCARLERNGVDLSREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V1R0</accession>
    <name>A0A317V1R0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IQ calmodulin-binding motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_479677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461585.1">
        <property type="nucleotide sequence ID" value="XM_025608754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V1R0"/>
    <dbReference type="STRING" id="1450535.A0A317V1R0"/>
    <dbReference type="GeneID" id="37110897"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF18">
        <property type="entry name" value="IQ CALMODULIN-BINDING MOTIF DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G08920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="879"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="882"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY66130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="997" mass="110511" checksum="FA5A139F37006479" modified="2018-10-10" version="1">MIRHNSDIEVQLPDAGTPVVSEPLNEPDVEMSSDELSLPLSLPAHLAARFARKPSVIRRSTAASSRRGSISSLHSQHSNASSHGASSTDHIAQHLRRTSILESRKARLADRALHAEKVRLRAALAKAATRNLQREERALAAQQARERLLAEITAKCEEEVRRAKKKAEDNRERKAAEHARLRLEIAEKFAEVEKRRMLYQQSHRRCRTSSLNSTEEKKMSRVSMSPITRDAAARTIQRAWRTHHSKLIMRQFLDLDLTTGGIREMAFEDVGALLSKDAVLDTTARVLRFCGLQDMESGTMGGRGAVRTFLSSYLIVTHPTEVLSSNGEQEQDLIAKARELLVAFDQVTPLLSSGCCSPLFISTEIQALCEAYNVFFSAFHAWKTHDSSVLIEIMLAQFIELELIWQTVKDDRAGGVAEDYRQGIRQNQILLLTKLKRLAGSDRAMQMVRDALKKAKREKKRTASKKQAIPRSAEVAPSSTEALTESVASPISETFNNVDSDVLQELDKQRISPHERFTRILTALPENRALVHELLINKGFKIDEKQYTEPRKRIMQHMCEMMRRDVDAGLGTNWTVAMATVIQDRLLRSLRPGNSLHVLISEVLDPKLVENQCKAGAFSYDNFFEFMNTILPKLCAPYRDPVVKAFVEDTSGDAIDRLARLMGIIDLLSLDHTNFMIQVAAPQLIQEAPGYEQRTFEKGVQDGSLGLGKSRRFWRTYRKVLADEMRKRDPENVNGEPQPPMAKVYAHGLVDLVLSNASMSDDLIPETLELDRHRLGRLHAQAFRIVATASILLTAKNLLKRDVRSQWKAEADRLLSLDFNDIQPDRVQSILESTHPMPPSASAQLAATIRRVLAPVGTACTAASPAGATPATVEIQMDPDTSTASSSASSPAGSAGSVGSSRSGASAASFTDPVARLILSRLRAHVLSRLSASSASERVRTTTTASQSLAGAGMPEFVMEVGQLTDELEKVREVDWLCHGVVYDRILAEGIPPRPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V234</accession>
    <name>A0A317V234_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="8">SDH assembly factor 3</shortName>
            <shortName evidence="8">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_540270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462098.1">
        <property type="nucleotide sequence ID" value="XM_025612881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V234"/>
    <dbReference type="STRING" id="1450535.A0A317V234"/>
    <dbReference type="GeneID" id="37115024"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY68076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="129" mass="14549" checksum="C861C67C0BDAE9B2" modified="2018-10-10" version="1">MSFLRLAPTATRLATPSTFGSKSSLSDALALLPPLPLYRRILHAYPRDGYVKSEFRAHKNVENPLHIIGFLTEWQLYAQKLEGDMWVGEKLEKAKLDKMSDQQIGQLYELMQAIQNKDGEGEGEGEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2K0</accession>
    <name>A0A317V2K0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_540194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462177.1">
        <property type="nucleotide sequence ID" value="XM_025612859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2K0"/>
    <dbReference type="GeneID" id="37115002"/>
    <dbReference type="OrthoDB" id="21471at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY68514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20747" checksum="A26B1150D171C0B4" modified="2018-10-10" version="1">MSSQPPTMISTPQTSEEEANLAVAKEYMSIAYSPTENKGAESVRHLCTPDSWFWGPSTFPGCSTPMDYAESHAHVMESVNNLHIVRYDQAWAKNGHVLLRYTAEGSHAGKPYQGIERSDPPRKARWSAAAIFEVEDGKIKSFTKDWDQKVMQIQLGWAPVQDSEDPRWNIDMLADPERARHLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4H4</accession>
    <name>A0A317V4H4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein bS18m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_540052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462389.1">
        <property type="nucleotide sequence ID" value="XM_025612830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4H4"/>
    <dbReference type="STRING" id="1450535.A0A317V4H4"/>
    <dbReference type="GeneID" id="37114973"/>
    <dbReference type="OrthoDB" id="21463at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.640.10:FF:000013">
        <property type="entry name" value="37S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_bS18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_bS18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479:SF40">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS18M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="Ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="37"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY69184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="196" mass="22040" checksum="1A355C93B9EF885D" modified="2018-10-10" version="1">MALHLFSWSPLRTVGSTLGSVSAVATAACRWNSTVAPNAPAPRRGLRPQTNKMYHNRRKPSRQQFLEDQRAQNEGRALEKFQTRDWSAGDVYSPHDLSPTEMKKWKKRNSPSTDAFDALNLNPLHLYKNFSIMSEYVTSMGRIKNRNTTGLRPVNQRKISKAIRRAIGLGLMPSVHRHPEILAAEAKARMEGGGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6L3</accession>
    <name>A0A317V6L3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_503395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462250.1">
        <property type="nucleotide sequence ID" value="XM_025609471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6L3"/>
    <dbReference type="STRING" id="1450535.A0A317V6L3"/>
    <dbReference type="GeneID" id="37111614"/>
    <dbReference type="OrthoDB" id="1705416at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43657">
        <property type="entry name" value="TRYPTOPHAN RNA-BINDING ATTENUATOR PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY68587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="360" mass="37979" checksum="CDC8BE8ED9FCCEC3" modified="2018-10-10" version="1">MSEQVVYPPPPSQGHSFPPPPNGAAFQPPPQASPSFPPPNFSFPPPPQQPIPSNDDKDDVSPISPSNGPPTPPMSEKAIYAAQNAGLFFNNSAVLNPPEKQPPPPGPGLVRAQTDAALGSRVAPKTFVGAQSTYADDVGTFNGGSYRISHRDTNTLLTIQLAVGCPIQARPGIMIAMSPSMSLRGSLSFGWMKALAGGQLARSTYTGPGEVLLAPSILGDVAIIRLDGATEWTVGKDAFLACTTGVNINYKTQGLMKGVFSGEGFIVFKFTGAGLVWMQSFGAIVKKELAEEETYFVNNGHLVAWNCKYKIERVASGGIISNWSAGEGLACRFTGPGTVFMQTRNVSTFVAHLNGVIAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6S6</accession>
    <name>A0A317V6S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_550921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462276.1">
        <property type="nucleotide sequence ID" value="XM_025613512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6S6"/>
    <dbReference type="STRING" id="1450535.A0A317V6S6"/>
    <dbReference type="GeneID" id="37115655"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016290418" description="Heterokaryon incompatibility domain-containing protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="57"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY68961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="221" mass="25891" checksum="E267F4B46754CA01" modified="2018-10-10" version="1">MTFVILSIFLKVVAPYEYEPIDLERPSFRLLHRGERSDKIKCELTQESFDSDNWCPYEALSYECHATELTDHITVNGERLPVNGSVFYALQHLRLSDQERILWGDAVCINQSNMAERKHQVQQMGHIYARAEQVIIWLGGSGYAENVLMDSIKYLERECRRHAYKDWKPTDEHWANIWSSGKEALRYRYPGIKETQESGMRLAVGNSWFKRVWTLQEVANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VA17</accession>
    <name>A0A317VA17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cation diffusion facilitator family metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_569654</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462565.1">
        <property type="nucleotide sequence ID" value="XM_025614746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VA17"/>
    <dbReference type="STRING" id="1450535.A0A317VA17"/>
    <dbReference type="GeneID" id="37116889"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000016">
        <property type="entry name" value="Zinc transporter ZitB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF5">
        <property type="entry name" value="DIFFUSION FACILITATOR FAMILY METAL ION TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="12">
        <location>
            <begin position="12"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="13">
        <location>
            <begin position="194"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY69867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="312" mass="34185" checksum="14ABE867F1FB12FE" modified="2018-10-10" version="1">MVFRISRAQRLMVVVGISSLFFVAEISVGFYTHSLALVADAFHYLNDLVGFIVALVALKVSEADDSPKALSFGWQRAQLLGAFFNGVLLFALGISIFLQSIERFIAIQRVENPKLMFIMGAIGLVLNLVSATFLHGDAANNLGVMAAALVIWLTHYAGRFYADPGTSMGIAVMIMLSSVPLVRRCGIILLESAPSGVDLEDVKHDLEKIPGVLSIHELHIWRLNQHKALASVHVMVSDYSVPNFLRLTKTINECFHAYGIHSTTLQPELARPETITADRQITEIEELGLPKEASEKCQVVCGTLCEELTCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBT3</accession>
    <name>A0A317VBT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_550295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463050.1">
        <property type="nucleotide sequence ID" value="XM_025613487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBT3"/>
    <dbReference type="STRING" id="1450535.A0A317VBT3"/>
    <dbReference type="GeneID" id="37115630"/>
    <dbReference type="OrthoDB" id="4187970at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY71814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="238" mass="26093" checksum="835E701A5C66C6EF" modified="2018-10-10" version="1">MAFQTFGSANFTSSRSLTIGSTLNGSQADRSTLRNVKLLAGSKASRSTATNSTIQQNSWVERSTVNRSTISGSSLHRSTLNECEVENCVLLRTAFSGMVLKNGVWRNGILVGKLQEGDVVMETRNGMIVPLPENLVLEVRDASHWLEGASRSEGAFDIDHLRGNIFSREFIFNPPGSTVTNQSTGRLYMGDDMTPTRFFDNFSSNGYAGMNMGRGINTAMHHNYERASSRSPPPPYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJZ1</accession>
    <name>A0A317VJZ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_589274</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463799.1">
        <property type="nucleotide sequence ID" value="XM_025615940.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VJZ1"/>
    <dbReference type="GeneID" id="37118083"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000381">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000487">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="HEAT" evidence="15">
        <location>
            <begin position="985"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="FAT" evidence="17">
        <location>
            <begin position="1241"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="16">
        <location>
            <begin position="1997"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="18">
        <location>
            <begin position="2358"/>
            <end position="2390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY74606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2390" mass="270248" checksum="A259FC79F1A880BE" modified="2018-10-10" version="1">MAQAAPITDLTNRLFAELKSKNEETRVRAAYELYDNVVAISRDWSPEKFLEFFNTVSQRIAQLVVTGNDAHEKIGGLLALDRLIDFDGVDAAQKTTRFASYLRNALRSNDNAVLIYAARALGRLAKPGGALTAELVESEIQSALEALQSERQESRRFAAVLVIRELAKGSPTLLYGFVPQIFELIWVALRDPKVLIRETAAEAVSECFEIIAARDMQVRQLWFARIYEEALLCLKSSNMDWIHGSLLVLKELLLKGAMFMNEHYRNACEIVLRLKDHRDPKIRTQVVLTIPILASYAPLDFTETYLHRFMIYLQAQLKRDKERNSAFIAIGKIANAVGVAIAQYLDGIIVYIREGLAMKARNRAAVNEAPMFECISMLSLAVGQALSKYMEALLDPIFACGLSESLTQALVDMAHYIPPIKPTIQEKLLDMLSLILYGTPFRPLGCPESRLPPMPSFMRDFAPQELHSDTEIALALHTLGSFDFSGHILNEFVRDVAINYVENDNPEIRKASALTCCQLFVHDPIINQTSSHSIQVVSEVIDKLLTVGVGDPDSEIRRTVLWSLDRKFDRHLARPENIRCLFLAVNDEVFPVREAAICIIGRLSSVNPAYVFPPLRKLLVNLLTSLGFASTARQKEESAQLISLFVSNATKLIRSYVDPMVTTLLPKATDANPGVASTTLRAVGELANVGGTEMKTYLPQLMPIILDALQDLSSHAKREAALRTLGQLASNSGYVIDPYLEYSHLLAVLINIIKTEQTGSLRKETIKLLGILGALDPYKYQQISETAPVVHHINEVQTVSDVALIMQGLTPSSEEYYPTVVINTLMQNILRETSLAQHHSAVIDAIVTIFKTLGLKCVPFLGQIIPGFISVIRVSPVSRLESYFNQMAILVNIVRQHIRAFLPEIIEVVREFWAASYQVQSTILSLVEAIAKSLEGEFRKYLAGLIPPMLDTLETDSTARRQPSERILHTFLIFGTSGEEYMHLIVPSIVRLFDRTQNPQNIRKAAIDTLTKLSRQVNVSDFASLMVHSLSRVVAGNDRLLRQAAMDCICALIFQLGQDFNHYIHLLNKVLKYHQISHVNYHILVTKLQKGDPLPQDLNPDENYAALADDTNYAEIGQKKMVVNQQHLKNAWDASQKSTREDWQEWIRRFSVELLKESPSPALRACASLAGVYQPLARDLFNAAFVSCWTELYDQYQEELVRSIEKALTSPNIPPEILQVLLNLAEFMEHDDKALPIDIRTLGKYAAKCHAFAKALHYKELEFEQDQNSGAVEALITINNQLQQSDAAIGILRKAQAYRDVELKETWFEKLQRWEEALAAYKRREKIDPDSFGVTMGKMRCLHALGEWKVLSDLAQEKWNQASLEHRRAIAPLAAAAAWGRGQWELMDSYLGVMKEQSPDRSFFGAILAIHRNQFDEATMYIEKARNGLDTELSALLGESYNRAYNVVVRVQMLAELEEIITYKQNIGDPEKQDSMRQTWNKRLLGCQQNVEVWQRMLKVRALVTSPRENLDMWIKFANLCRKSNRMGLAERSLASLETVVSDSNGTRAVAPPEVTYARLKFNWATGRQRDALQMLKEFTSSLTEEFTRFNALMMSQPDHNGVNGVNGVNGVNGIADANHADVMGLRERIGDVAKFRRLLAKSYLRQGEWQTTLQRGDWRPEHVREVLNAYAAATKYNRDSYKAWHSWALANFEVVTTIASQASRDGTTMAMVPGHIVTEHVIPALRGFLRSISLSSTSSLQDTLRLLTLWFTHGGDQEVNSVVAEGFTAVNIDTWLAVTPQLIARINQPNIRVRSAVHRLLAEVGKVHPQALVYPLTVAMKSNVARRSQSASNIMDSMRQHSAKLVEQADVVSHELIRVAVLWHELWHEGLEEASRLYFGDHNVEGMFATLAPLHEMLDKGAETLREVSFAQAFGRDLAEAKHYCMLYRETEEIGDLNQAWDLYYTVFRKISRQLPQLSTLDLKYVSPKLKDCVDLDLAVPGTYQSGRPIIRIISFDPILHVLQTKKRPRRMTLKGSDGNSYMYCVKGHEDIRQDERVMQLFGLVNTLLDNDGESFKRHLSVQRFPAIPLSQSSGILGWVSNSDTLHALIKEYRESRRILLNIEHRIMLQMAPDYDNLTLMQKVEVFGYAMDNTTGKDLYRVLWLKSSSSEAWLERRTNYTRSLGVMSMVGYILGLGDRHPSNLLLDRVTGKVVHIDFGDCFEVAMHREKYPERVPFRLTRMLTFAMEVSNIEGSYRITCEAVMRVLRENKDSLMAVLEAFIHDPLINWRLGIRESPDRMPFSAERRQSVVSNINLDHGVQPSNFSRHRRPSILEGGILDAQEGIPNEAREAQNARALQVLARVKEKLTGRDFKQSEELNVSDQVDKLLAQATSVENICQHWIGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKS0</accession>
    <name>A0A317VKS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">KH domain RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_474880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463583.1">
        <property type="nucleotide sequence ID" value="XM_025608535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKS0"/>
    <dbReference type="STRING" id="1450535.A0A317VKS0"/>
    <dbReference type="GeneID" id="37110678"/>
    <dbReference type="OrthoDB" id="442947at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="127"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="282"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY73831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="364" mass="38853" checksum="E8EC8F9CA8D52551" modified="2018-10-10" version="1">MDATDLHDTTMVDEASPDVVNMMDDVDIETTPKTEEEYAQSMLTLRAIVSSKEAGIIIGKSGKNVADLRDETGVKAGVSKVVPGVHDRVLTVTGPLNGTARAYALVAKGLLEGAPQMGMGGIVSNNGTHPVRLLISHNQMGTIIGRQGLKIKHIQDASGVRMVAQKEMLPQSTERIVEVQGTPEGIEKAVWEIGKCLIDDWQRGTGTILYNPAVRASVGTSSTSSSMSPSVGGGSGNGYNSRPYNRTGNGADFSDQSGGYGRRSNPDTSNRGYPLVTEDGDEIQTQNISIPADMVGCIIGRGGSKITEIRRSSGARISIAKAPHDETGERMFTIMGSAQANEKALYLLYENLEAEKTRRSQLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VM23</accession>
    <name>A0A317VM23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ribosomal protein MRP51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463802.1">
        <property type="nucleotide sequence ID" value="XM_025612557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VM23"/>
    <dbReference type="STRING" id="1450535.A0A317VM23"/>
    <dbReference type="GeneID" id="37114700"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="50072" checksum="7FDD35CCA2FEE371" modified="2018-10-10" version="1">MATARLSPTANLLRNSRLFALPQALTPPPTPPTSKFVFESETATLPHPIRASIATPASSLSRGDWGLKRPLPAKSTHEKSSRPVVRIKALDTFEHITDFESAADHTVTLEKFQELNMPMSLPGQIHYATASTPRHESPFESHIDNTHTSEGRNEPGAKQFRQSGPWLAGQTEAEFQAYLKSIRKNKPEILQKLRGYFVAKREAEQRKQAQDNGADLEALEPVEVTDEEFQAYLKALRNDQASLGPVIFELLDLPSPPTVPTERIGKRGYPSPGSKLSSGEYAVSGPPKTHPSAGLSYSRSHALIYNHPKYGPQAYQRPVEARILRPKGRFKGKNSKAIAGVAGFAVEDINAMTFHEQGAPYGLKTLDTTTPGGSKYWVTPIRATIDSAGKVGLFSYRASTTAKAPYGIESPNMPVYYNITDKARGRQRVVPRLDGQPGPQAPREEVARNLMKSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VMW4</accession>
    <name>A0A317VMW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_231010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463774.1">
        <property type="nucleotide sequence ID" value="XM_025606298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VMW4"/>
    <dbReference type="GeneID" id="37108441"/>
    <dbReference type="OrthoDB" id="5402392at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="544" mass="60848" checksum="EDFA8A5027ADF665" modified="2018-10-10" version="1">MAQPPEDTHASPADIPDIVKPLAPYIKSRQEALRIRQALTTYLRSHIEFAENDPEHPGCHSQSHLSLSVPHDAVVGVKRIPSELTGLRKKYLESLRANVAARKEFQSVVEKTTSIKHKGGKARAEELSVGSSSELQEYLKLLRDRRQHAKLQVFQHYLQELKQRDTFKSVDLEANAARYQQLAPPGELEDNQHGPKAGESIEELMHKLERAIIRAKAQLEREKGLLEELKARRASEGPRDVPPAVKALALQRTRDVLVHWVEEKLVSVGNSENSGATQSFRPEDIEESVRLLEEKKARIAQQYAAYADARKRLLDAASRACQPIALPSTSPPTRPTSMVQGRNAMNETQSLDALELLSFTSDVLQPLSKSQRSLALQKFYLSGMLAKEKATTLRALNRLRDESHLLPEYPILARQPRFKHATAALASRQGTNTEPAKPDEIVGLAEAWAFASNAAKTSEQEYVEHKLEEGTEAAQDAMHVLEDVYKILNQSLEDTLRDRDGEMGENDIWASEARLTRSRAKTQRTQQSAKGPWFGLHGKVGVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQ59</accession>
    <name>A0A317VQ59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_588815</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464309.1">
        <property type="nucleotide sequence ID" value="XM_025615907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQ59"/>
    <dbReference type="GeneID" id="37118050"/>
    <dbReference type="OrthoDB" id="5234029at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY76496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="428" mass="45591" checksum="6CEB6AB3D23763DE" modified="2018-10-10" version="1">MTRIPSPTAEQISSTAGPSPAKNESLPPIVSLRLAIVVVGIGFAIFLGALDVNITDEFHSSSLTYHCSVGQRVIPPLTSHSVDSLLTLSSLQLAWGRLYKSFPAKGTFLDALVVFEVGFLGCGACPISVDLIVGRAIAGMGVSGGFSGAMIIASYTIPLHLCPLMNSALAVLMGSTRALGPVSGVALIMKASWRWCFYINLPLGALCGLLIDLGAAIPQSSGTSSKSWTTKLRWFDWIRMLLWIPFTVCWSSFYSSGASSSPGTTRASSTIWGTIFEFLIGGSSQLRQHFLPIYFHAVQRKSALTSGTSTLPLLVAYTTSLILTGIATLAVDQYASIMHVGSAIASVDMGLRTSAVSTLTAHTHPEPVDRVPDPQRGSGKQHRQQADGMAALLKTLTGLGLVYALEIKCPSARRGRYLPMRNSEVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSV3</accession>
    <name>A0A317VSV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_605194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSV3"/>
    <dbReference type="OrthoDB" id="3868412at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="92" mass="10393" checksum="471E5AD8163C497F" modified="2018-10-10" version="1" fragment="single">SSTYDHRVWRTGLPVRSAVLKPHAGRLVVGWVTTSESLLLYVFLLVHLISSIFIFAFWYLSYENLLGPWVSVCFGGGGAPLWENRTVNLPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VV11</accession>
    <name>A0A317VV11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_522952</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464388.1">
        <property type="nucleotide sequence ID" value="XM_025610197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VV11"/>
    <dbReference type="STRING" id="1450535.A0A317VV11"/>
    <dbReference type="GeneID" id="37112340"/>
    <dbReference type="OrthoDB" id="412182at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY77201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="517" mass="58738" checksum="5F80B178496BD3DE" modified="2018-10-10" version="1">MTNIHPESPEDFEFIETPPASCTTPADDCGVRTTSYPAIKNAPVPADSQGSDSFSNTLLFALLILVPWYLARQIGGGFYTTIFLAIFTTVPILMAFWSIASSISPRKNEKAKYAGRPVEYYLNFHSEHDRTAYRGKSKIPMEVFYEKYFNGEVDFKCDALEALEFRHDWANFRFTMGLYKHFLFGFLPEMLMHTRSQDEEQVRDHYDRGDDFYAWFLGPRMIYTSGIISDPEKEETLEELQDNKLAVVCEKIGVKPGDTVLDLGCGWGTLAKYASVHYGAQVTGITLGRNQTAWGNKGLRNAGVEEDQSRILCLDYRDAPRVPGGYKKITCLEMAEHVGVRHFTSFLSQVYDMMDDDGVFFLQIAGLRKSWQYEDLIWGLFMNKYIFPGADASTPLGFVVDRLEAAGFEIKSVDTVGVHYSATLWRWYRNWMGNRDKVEAKYGKRWFRIWEYFLAYSTITSRQGGATCWQLTLVKNINSTHRVEGINNQYGLSGARQAAIDRAGHGALPKAHVPPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVN3</accession>
    <name>A0A317VVN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SPX domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_522068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464745.1">
        <property type="nucleotide sequence ID" value="XM_025610167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVN3"/>
    <dbReference type="STRING" id="1450535.A0A317VVN3"/>
    <dbReference type="GeneID" id="37112310"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000002">
        <property type="entry name" value="Vacuolar transporter chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF2">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 3 COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="690"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="728"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="556"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="791" mass="90580" checksum="28DEC25CCC5793CB" modified="2018-10-10" version="1">MRFGKTLRNSIYPPWAGNYIDYHRLKVLLREHDVIGDGSDSESTPWTEQDEEAFVQELLNVQLDKVNAFQMETLQQLRERTTTCETRLRPLTTSTDDEPPVAIEDEEKKRVASDVMQELDGITKEVTELEKYSRINFTGFLKAAKKHDRKRGTRYRVKPLLQVRLSQLPFNSEDYSPLVRRLSVMYSFAREILSQGVVEAKDPAEPRIGQDVYSSFKFWVHADNVLEVKTYILRQLPVLIYNPGTSKDLNTVPDDPTITSLYFDNPQFDLYTQKVARAPEAGSLRLRWTGNLHDKPAIFLEKKVVTDDDRSREVKVQLKQKHVKEFLDGEYRFDKKVHRLENMGNGDSEQAEALKKDVDELQSFIKEHNLQPMLRANYTRTAFQIPGDDRIRISLDTNLALIREDSLEELRPCREANEWHRRDIDDAGMEYPFQSIRTGEIARFPHALLEIKLRGDATHSAEWVKDLMVSHLVKEAPRFSKFVHGVAQLFEDYVNSFPFWLGELESDIRRDPATAFNEERERLAKRVEDEMAVGSFLGGKSPSTRLMVGSPVQMFTETESSRHRQSPQIVQPSPRPSAPEVAGTPERQEPVEDAEQEVEPPVTMKRLAALFPSFNIARQNRANADTVVLPPGVRDPGTWIKDSGPVRVETKVWLANQRTFIKWLHVSILLSSLSLGLYNAAGKNNDIARALSIVYTSFAIFAAGWGWYMHEKRARLIRQRSGRDLDNMFGPIVVCIGLAIALVLNFAFKYNSTLERLRDNQPVEPVPGLNSTAFINKSNMWQLVNQGGHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWC6</accession>
    <name>A0A317VWC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_568281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464504.1">
        <property type="nucleotide sequence ID" value="XM_025614671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWC6"/>
    <dbReference type="STRING" id="1450535.A0A317VWC6"/>
    <dbReference type="GeneID" id="37116814"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY77317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="525" mass="60464" checksum="F44B211EB94A6BCB" modified="2018-10-10" version="1">MQQIFTTRTLPQRVSPTTQRLSQSLSTINTPAADSGTPNPDLFSYTSGRYLYNEKLRFEERHVEFNVEALREIAASAVGGKHVVQLRKLAEGGFNRVFALTMDDGLDVIAKIHYPLTVPKTYSTESEVATLEFLRLKGIPVPRVYAYSSTSDNAVGSEYIIMEKAPGQPLERRWFELSPKERVRLVTSFVEIEQKLFAIPFASYGSLYYKDNPSADYMFWRGKRAALDLNRGPWKDHRDYVRSVGQRELEWATKYGKPRQNDFPHNNMMKGEISPDIYADLLKRYILISPHILPSDHANAMNKPTMRHLDLNPPNVFVNDSCEVSCIIDWQHRSTLPLLLTAGNPPLFQNTDSEPPKSLAKPSLPDKYDSLSLEENSELTNSIVGEYNKSHLQALRYPLLAIRQHAVESADRQWSGNVITLKGALIRLWEHWDKLIADSQQKVECPIFFDKEDVEEFLVAEGHWFKATILLEHWRSLLDDLGQDGWVRHESYEQLKQEWLSLAEDEEDSVSVDQFWPFQDHEEYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXR3</accession>
    <name>A0A317VXR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Dihydroxy-acid and 6-phosphogluconate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_471900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464738.1">
        <property type="nucleotide sequence ID" value="XM_025608403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXR3"/>
    <dbReference type="STRING" id="1450535.A0A317VXR3"/>
    <dbReference type="GeneID" id="37110546"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052352">
        <property type="entry name" value="Sugar_Degrad_Dehydratases"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004784">
        <property type="entry name" value="PRK06131.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183:SF1">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXY-ACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43183">
        <property type="entry name" value="HYPOTHETICAL DIHYDROXYACID DEHYDRATASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="7">
        <location>
            <begin position="58"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="8">
        <location>
            <begin position="386"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="608" mass="64580" checksum="95C1C966658F5618" modified="2018-10-10" version="1">MEDTTAHTPLSDYDLSTSITSTSGLRQGLASYGDAHFSLFLRKVFIKALGYSDDALSRPIIGIINTFSGFNPCHANVPQLIEAVKRGVHLNGGLAVEFPTISVHESFSYPTSMFLRNLMSMDTEEMIRAQPIDACIMIGGCDKTVPAQLMGGISANKPILPLITGPMLPGSHRGERVGACTDCRNNWAAFRAKEIDIEEIAAINEELAPTVGTCGVMGTASTMACVTAALGMMPLRGASAPAVSSARIRVAEETGANAVSVARVERRPQDILSKESFLNAITVLQAIGGSTNAVVHLMAIVNRHPKVQGLITLQTIEEVGQKTPLLIDLKPSGDNYMNDFHNAGGMLALLHTLRPLLHLPAMTITGQTLGEVLDASAFRIFPLSQQIIRPLSDPLHPSSSLVVLRGNIAPDGAVMKASASKDRRLLSHSGPAVVFENSADLAKRIDDPDLHVTQDSVLVLKGIGPVGNPGMPEAGLIPIPRKLGSAGVKDMLRLSDGRMSGTAGGTVVLHISPESALLESPFGVVQTGDLITCDIATRKLQLEVSDDELKRRIDARKQLSNSGGAAASQAKGRKRGYHGLYERSVNQAQDGADFDFLTASGPLSDDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXR8</accession>
    <name>A0A317VXR8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Triacylglycerol lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_568101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464643.1">
        <property type="nucleotide sequence ID" value="XM_025614662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXR8"/>
    <dbReference type="STRING" id="1450535.A0A317VXR8"/>
    <dbReference type="GeneID" id="37116805"/>
    <dbReference type="OrthoDB" id="5592486at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="352" mass="39221" checksum="63BA6B5D72A75F3B" modified="2018-10-10" version="1">MRYAVAGFHGARCIKVRFQFLSVGYSAQRFLHSSTPKHHPEEHDAPDALDPRLEDLGKVIRDEYAIVREQYDTPKHPVVLAHGLLGFDELRLAGPYLPGVQYWRGIKEALSMKGVRVITATVPPSASIELRAEELAKDIAIGARGEHVNIIAMKKSIGSLATVNRCSSGLDSRYMITHLKPNDFKVKSLTTIATPHRGSAVADYVLKQIGDDRLTQLNYALDRLKVETGAFAQLTPDYMTKSFNPTTPDIEDVRYFSYGAAMQPSFWSVFRLSHRLLEQVEGYNDGLVSVASSKWGGDQGYKGTLEGVSHLDLINWSNRLKWLAGKITGNRPRFNAIAFYLDIADMLAKEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYK1</accession>
    <name>A0A317VYK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_537877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464604.1">
        <property type="nucleotide sequence ID" value="XM_025612370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYK1"/>
    <dbReference type="STRING" id="1450535.A0A317VYK1"/>
    <dbReference type="GeneID" id="37114513"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="181" mass="20691" checksum="2397300E0C5EBA47" modified="2018-10-10" version="1">MASTLTLPQLPAKHRDLPRWIQSHPKPPLNQITAPYNNYDAVVRKLFAQDPSHTALQDNHLNIVPLYDSSGLTDVRVRARDLASEPSTMKERYIMPLKEQDRRPNGSPAVVPRLDDFWRNFNIFSEGALSDIDWSNVVVAGSAVVTCLLPVPEEYRDSKRAMLCSSPAKRKWESNRWRIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZB0</accession>
    <name>A0A317VZB0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 14">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_472863</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464417.1">
        <property type="nucleotide sequence ID" value="XM_025608452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZB0"/>
    <dbReference type="STRING" id="1450535.A0A317VZB0"/>
    <dbReference type="GeneID" id="37110595"/>
    <dbReference type="OrthoDB" id="121051at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000008">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000006">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000004">
        <property type="entry name" value="DNA mismatch repair protein Msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001909">
        <property type="entry name" value="DNA mismatch repair protein msh3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF122">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="17">
        <location>
            <begin position="966"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="175"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY77230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1119" mass="122985" checksum="0FA037F70780ABF3" modified="2018-10-10" version="1">MPLPSSQPSSSPALKRKQSTIASFFTKKPQTAQRDSVNVDEDQGSGARAEKAATQEKVQDQKTGLADDKDNDIVAPAPKRARANRPRSGDKDANSNWASASTIERPPALSSSQRTELFMFTSSPAVHTGTEAPSETIEPEAKQRQKERGELHQRFVRKLGGADCLIGIGRNAVSEVTSAEDGPEAEDDEEPAPPAKGKATGKKGGSKLTPMEKQVIDIKRKYMDTVLVVEVGYKFRFFGEDARVAAKELSIVCIPGKLRFDEHPSEAHLDRFASASIPVHRLHVHVKRLVAAGHKVGVVRQIETAALKAAGDNRNAPFVRKLTNLYTKGTYIDDVEGLEGPMPAASGGASPATGYLLCITETNAKGWGNDEKVQVGIVAVQPATGDIIYDDFEDGFMRSEIETRLLHIAPCEVLIVGELSKATEKLVQHLSGSKLNVFGDKTRVERVTKSKTAAAESHSHVSSFYARKMKTASAADDAQASSLLQKVLNLPEQVTVCLSSMIEHMKEYSLEYVFELTKYFQHFSSRSHMLLNGNTLMSLEIYQNQTDHTTKGSLFWTLDRTQTRFGQRLLRKWVGRPLLDKSRLEERVNAVEELKNPERTVMVERLRGLLGKVKSDLEKSLIRIYYGKCTRPELLTVLQSMQMIAQEFSGVKSPSDTGFISAAINEAITCLPTILDDVVAFLDKINMHAAKSDDKYAFFREAEETEDISDQKLGIASVEHELQEHRSVAGEKLGRKMVEYKSVAGIDYLIEVDNSSASIKRVPASWMKVSGTKKVSRFHTPEVIQLTRQRDQHKEALAAACDKAFIGLLGDIATKYQPFRDCVQALASLDCLISLATIAGQPGYVKPEYTDHTCIHVDQGRHPMVEQLLLDSYVPNDIDLDSDRTRALLVTGPNMGGKSSYVRQVALIAIMGQIGSYVPARAAKLGMLDAVFTRMGAFDNMLAGESTFMVELSETADILKQATPRSLVILDELGRGTSTHDGVAIAQAVLDYMVRSIGSLTLFITHYQHLSSIVHSFADHALRNVHMRFTESGAGADEEITFLYEVGEGVAHRSYGLNVARLANLPGSLLEQARQKSKELEEKIRRRKLAGLVAAVGGVMEGSQDDGMIERLVSSAEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1G2</accession>
    <name>A0A317W1G2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sec2p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_169620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465013.1">
        <property type="nucleotide sequence ID" value="XM_025605915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1G2"/>
    <dbReference type="STRING" id="1450535.A0A317W1G2"/>
    <dbReference type="GeneID" id="37108058"/>
    <dbReference type="OrthoDB" id="1748564at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="126"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="126"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY79441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="692" mass="75978" checksum="9E88790CDA000001" modified="2018-10-10" version="1">MADFIAFHTYYSRHNFLTPSTMLPRPTSHKRSHSSENNSLSPDKTVTKARSTNDLSGIAAEKPAPGLRSSSVGNFQESSFSTLRDPRLASHSEESETPGSTQSHHPDLSNEVAALSVKLVQAINNQTTLDDNLVATRQELEQAQAKIRVLESENENYQRDIDQEVLIKKADVDYEMLRLQAALAEEKAQRALAEKEKKGIEQELETLTAALFEEANKMVAAAKLEREAVEKKNEQLRSQVKDTEALLASHQEQLAELKSVLQALNISKDDIDARTINSTAPSSPTAPRHPLHIKKNSETPDIPEETVPCEEITPGPSTSFPHLIKSVCRTDIQAYEDFRELFTTSRASKPASRATSGSYAGLNVMSLASLGSGGFGSASSSPAKSQTHSPNGSVSSPQPVTSHIPLKETRFYKRVLAEDVEPTLRLDAAPGISWLTRRSVLSGICEGSLLVEPMPPSAKKYEFPCSLCGERRNGSINERTHRFRTSDSETAQRYPLCVLCLEKVRSCCEFTGYLRLILDGHVRIGDSEEEKDAWDETIRLRERMFWSRIGGGIIPLFAHNNGFQGNIPTFNENAEVLAAESREECQRSVISTIPEHMTIQTKNLDEIDSEHVHDEGSVGDDPFVSAPSESESTASSTAVSPIEANAPVEKADLGDDMDKQSIVQIAASETTHDETETVQPTVEVDAAKSGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1P0</accession>
    <name>A0A317W1P0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Cation transporting ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_471092</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[protein]-with a C-terminal TM segment(out) + ATP + H2O = [protein]-with a C-terminal TM segment(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66168"/>
            <dbReference type="Rhea" id="RHEA-COMP:16963"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:90782"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465252.1">
        <property type="nucleotide sequence ID" value="XM_025608368.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W1P0"/>
    <dbReference type="GeneID" id="37110511"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140567">
        <property type="term" value="F:membrane protein dislocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07543">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000049">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000054">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000071">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057255">
        <property type="entry name" value="2TM_P5A-ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047820">
        <property type="entry name" value="P5A-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23143">
        <property type="entry name" value="2TM_P5A-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="542"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="565"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1459"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1538"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1578"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="17">
        <location>
            <begin position="28"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="P5A-ATPase transmembrane helical hairpin" evidence="18">
        <location>
            <begin position="360"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="597"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF23143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY80393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1633" mass="181978" checksum="188059280FF5B864" modified="2018-10-10" version="1">MIEFKGRSESIFVVTVVFLVISFISVCLRCFVRLRLVRAFGWDDALMVFAMALEILFALCGITGSLYGMGQKLEQLGSGHLETAMFWWWLGQTSYVVTVVVAKISIALALLRLTVSKIHTILLWSVVGVSIVVGLVFWFMLTFECKPVSHFWQRESPGSCMSTDYLLDIAYVYSVTAMLCDLILGLLPIFLVWKLQMSRQTKAALAGILSLGCVASAGVIVRIPFLPTYKDPEFLYATTQISIWSNVEAGLGITAGCLVTLRPLFRWLGGTSYVTTHSKRTAGSMPLSSINGPGKHSRSEHTANSTKFWRPDLDPEDSRGVITTVQTAQGSRNSSQEDLNPKPSAWNGVNIKYSSLHNPLPTQLHTYVWPFLIIWPAFLAFYLSPERYDTYIQGQEWTFVWVGSIITVQSLLWLMTNWNINIQTLFTTTKARSIDSARLIKVIPAANAGSAEVCPLVLDTRGGKKTLSFLFQKRRFLYYPERRCFAPLSYVLDADPKPALKTFQKSQGLVSKEEVDRIRLYYGDNTFDIPVPGFVELWKEHAVAPFFVFQIFCVGLWMLDEYWYYSLFTLFMLVMFESTVVWQRQRTLNEFRGMNIKPYEVWVFREKQWQKTTSDKLLPGDLMSVNRTKEDGGVACDILLIEGSAIVNEAMLSGESTPLLKESVQLRPGDDLIEPDGLDKNAFVHGGTKVLQITHANTTPDDVASSKDGSGILPTPDAGALGVVVKTGFETSQGSLVRTMIYSTERVSANNVEALLFILFLLMFAIAAAWYVWQEGVIRDRKRSKLLLDCVLIITSVVPPELPMELSLAVNTSLAALSKFAIFCTEPFRIPFAGRVDVACFDKTGTLTGEDLVVDGVAGLTLGQTGAKVEKDGAHSELAKGGNIGIDTTLVLASAHALVKLDEGEVVGDPMEKATLKWLGWTLGKNDTLTGKTSPSTGSSQAPESVHVMRRFQFSSALKRQSTIATVVFDDRNTHKKVKSTFVGVKGAPETIRTMLVDTPPHYEETFKYFTRNGARVLALAYKYLSHEAEFSRARINNYTREEVECDLVFAGFLVLQCPLKEDAIKAVRMLNESSHRVVMITGDNPLTAVHVARQVEIVDRDVLILDAPENDTSGTKIVWRTIDDKLNIDVDPTQDLDRRILETNDICVTGYALAKFKGQKALPDLLRHTWVYARVSPKQKEDILLGLKDAGYTTLMCGDGTNDVGALKQAHVGVALLNGSPEDLTRIAEHYRTTKMKEIYEKQVSMMQRFNQPSPPVPVQIAHLYPPGPSNPHYQKAMEREAQRKGTPIQSAPAPTEAIPTITSPGAQALQQSNSNLTADQQRRQQASVAAAGFADKLTTSMMEQELDENEPPTLKLGDASVAAPFTSKLANVIAIPNILRQGRCTLVATIQMYKILALNCLISAYSLSVIYLDGIKFGDGQVTISGMLMSVCFLSISRAKSVEGLSKERPQPNIFNVYIIGSVLGQFAIHIVTLIYLSNYVYSIEPRQSDIDLEGEFEPSLLNSAIYLLQLIQQISTFSINYQGRPFRESIRENKAMYWGLVAASGVAFSCATEFVPELNEKLRLVPFSTEFKMTLTVLMIFDYAGCWLIENVLKRLFSDFRPKDIAVRRPDQLRREEERKQKEAMEQQAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2M3</accession>
    <name>A0A317W2M3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_567834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465094.1">
        <property type="nucleotide sequence ID" value="XM_025614652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2M3"/>
    <dbReference type="STRING" id="1450535.A0A317W2M3"/>
    <dbReference type="GeneID" id="37116795"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="197"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY79522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="685" mass="78488" checksum="E93036FC80AD584D" modified="2018-10-10" version="1">MVPSVDPASDRNPDPMCPHRDLRLDSNVFGILEPLGRFLENAPTCLGWVTMAIEKSEEAPLLIVPQVTLQVQQSVDPPTWNSPTRTGASFHFLQRATNPCYESPGRDGEPVDGARYVERLVANSLEVVEDSGSPVAFQRAQQWLSFCEENHEACKPPNPDFFPRRLVNMGSWDGSHEPFLYEPTTPVLLTTTTDNIKSCYEKITITTLPLALQDAIMVCRNLKIPNLWVDSLCIIQDDIVAWLHDASTMYDVYLNSHLTITVMEPNSCKSRFLSKQRFGDPSWQQLFHPSMSDSRNGTPSMDGLIRPGEFKPRSYEDRSSLNQRGWCLQESLLPNRRLCYDGNEMIWECVCRQLCECGHVVPPQVPRDTIPGYIKLGALFKTHVLRGSYPSNGLNFLEWHRARSTWRMKLPPHKVPYQRWRDLVMDYTYRTLSKKHDRLRALSGLARMVWTNLRHEDETSELYLAGLWRKELLFDLCWQVRPLDEVAEPPETGVESPEEAGYHIPSWSWASVERPVTYKFALPLEGWKYKPSLVDECVVENVSCQNEIPEGPTSAVIEGSIVLNGSFAPVKLIRGEKELDKFRRKTGFPTSGEMGAFHEEEVELDRPELDRPNGHYYCFRLFSWLTRRMGSQTWFRVLAASTHQTGAFERIGIWHLHVHPEEDTYFARVSCPIFKDAKSASVRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W526</accession>
    <name>A0A317W526_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_567338</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465804.1">
        <property type="nucleotide sequence ID" value="XM_025614622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W526"/>
    <dbReference type="STRING" id="1450535.A0A317W526"/>
    <dbReference type="GeneID" id="37116765"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF4">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY81736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="533" mass="58600" checksum="F834CD5270BD9192" modified="2018-10-10" version="1">MSSTQGTQQDAVKDQVMTGLQAMEIDGSSQEGDGVNGTRNDVTDMDRMGKAQQFKRNIRPLAALSFSAVLQATWEYIMLSDYEGLQDGGLAGMLWTYVWSSIGFGFIIVSLAEMASMAPTSGGQYHWVSEFASPRYQKFLSYVTGWMSVLAWQAGTASGSFLTGTVIQGLISVRDPSYNPTGWQGTLFVFAMILIALYFNIFGSNLMARMQNLLLATHVFCWVVVVVTLWVLAPLQSAEAVFTKFENFGGWSSMGLTVMVGQLAAIYGCLSSDATAHMSEEIKDAGRYVPIAITWSYFANAILGLVVLITMLFATPSVADSLSDDTGFPFIYVFKQATNTAGVNGLTAIILIPVILSNILFNASTARQTFSFARDRGLPFSSWIAKVDEKRKLPVNSIILSCIISALLSLINIGSETAFNAIVSLNVAALMFSYSISMSCLIWRKIWHPHTLPPARWGLGRYGLAVNIIGWLYVLFALFWSFWPESTPVTADTFNWSVVIFMAVFLLSLVMYVVQGRHQYDGPVTEVKRCGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W985</accession>
    <name>A0A317W985_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_536840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465636.1">
        <property type="nucleotide sequence ID" value="XM_025612125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W985"/>
    <dbReference type="STRING" id="1450535.A0A317W985"/>
    <dbReference type="GeneID" id="37114268"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY81568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="298" mass="32567" checksum="E15C1108748B3930" modified="2018-10-10" version="1">MTKAPVASIKHRLAPSHTFPAPILDALVAYVSLLYPPAGAPYRPVPANKIILAGNSSGTNLCFGLTKVLLELQKLPRSDASIDFHRRRVTLPLPAGIATVGGWCDQCDALPSWHRNGEYDCLGVLQPPCMPGFPTDSVWPANPPREHPYCVAATLDHELVTPAAVGDWTGAPPMLLLCGCEEAGVDGNRVVASQAAKSGVSVLWNEYEGMPHEFPLIMSSLPQAKHAFELWARTCKDFAESKPVRSSAVRWLMPDCGKEDLGDPRNLSPLPFTEVRRRMREYNATRSVWTGKLGQPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBB4</accession>
    <name>A0A317WBB4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Aminomethyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 8">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_587006</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The glycine cleavage system catalyzes the degradation of glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="2 8"/>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465886.1">
        <property type="nucleotide sequence ID" value="XM_025615796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBB4"/>
    <dbReference type="STRING" id="1450535.A0A317WBB4"/>
    <dbReference type="GeneID" id="37117939"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006487">
        <property type="entry name" value="GcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="10">
        <location>
            <begin position="392"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006487-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY83101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="482" mass="51488" checksum="2B43567C998034A3" modified="2018-10-10" version="1">MSAVRPMKRGLHLLSSSSLCRAAPVAGNGSALLPRPLSTSPRALRSAGVTVAAARPLPRVASLAAQGGVRYASSAAPSGPVKKTQLYDLHLAWGAKMVPFAGFSMPLQYSDLSHVESHHWTREKASLFDVSHMVQHQLSGPGALDLLMKVTPSSLDKLNHNQSTLSCLLEEGTGGIVDDTVITRRTDDTFYFVTNAGRRTEDLAFLEAEIDNYKQIHGADSLKWEILEDRALVALQGPKAASVLQSLVSPDGSNSDLSTLYFGNCRELHLTFPDGTTTPEPLLISRTGYTGEDGFEISIPTASDASLPARVTDLFLSNPDEVRLAGLAARDSLRLEAGMCLYGSDISTSQTPPGASLTWLVGKERRDPATATFNGASTVLPQVASPKTLSQRRVGFTVEKGSPAREGAIIVDLNDESRTQIGVVTSGLPSPSLGGTNIAMGYIKNGLHKKGTEVGVVVRNKIRKATVTGMPWVESKFYRPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD87</accession>
    <name>A0A317WD87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD binding Rossmann fold oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_575883</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466411.1">
        <property type="nucleotide sequence ID" value="XM_025615106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD87"/>
    <dbReference type="STRING" id="1450535.A0A317WD87"/>
    <dbReference type="GeneID" id="37117249"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="20"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY84486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="543" mass="61107" checksum="39636B97F9F1C779" modified="2018-10-10" version="1">MKEPALPTVSLPLTPSPRSLRFLIIGAGSRGTAYARAVTTATQGSIHAVAEPHPFKRRHLGRSYIWGEHGSPQDGQEFPDWRSWLQWELQRRESNNDPRVGVDGVFICTLDSTHVEILHAIAPLRLHILCEKPLALSLNDCLSVYRALTPNLSTNIFSIGHVLRYSPHNVLLRKLLLLDRVIGDIVSLEHTEPVGFWHFSHSYVRGNWRRETPNGDGSLLTKSCHDIDFIMWLLSSPPTDTETTPHHPRTITSSGSLTQFRKSRKPPAARDATNCLSCPAERDCVYSAVRIYNDMHVAKGDLDWPVNIVCEDIEDVITPPRKDKDTPLTQESIHLAQSHLLTRLAEDYPSTSTSTTTTDPETIHTRPWYGRCVYESDNTVCDDQTVTITWDGEAPKTALFHMIAPTEKQCERRGRIYGTLGEISYDSRTITIYSFQTRETTTITVPKRPPEEEKAHGGGDYGLARSFVDAVDAVVNKGSGVREAQRRFVGCDLEEAVRSHAVVFAAEEARREEKVVKWREWWAEKTGGGCCSWESEWGSVMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDJ3</accession>
    <name>A0A317WDJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_119129</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465913.1">
        <property type="nucleotide sequence ID" value="XM_025605564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDJ3"/>
    <dbReference type="GeneID" id="37107707"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="93" mass="10302" checksum="C02FDF06C54C86F2" modified="2018-10-10" version="1">MYYSKYVVVVMVVVVVVVGMCPKTVPPVSPRQEKIQAAASQSPHAISKKKYSTNQAQTWGEPNRRPGADAKKETPTRMHENNTSPGDIYRSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEN3</accession>
    <name>A0A317WEN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_100769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466410.1">
        <property type="nucleotide sequence ID" value="XM_025605449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEN3"/>
    <dbReference type="STRING" id="1450535.A0A317WEN3"/>
    <dbReference type="GeneID" id="37107592"/>
    <dbReference type="OrthoDB" id="5421784at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY84485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="59152" checksum="5FF8B3FD0382D1C0" modified="2018-10-10" version="1">MAHHGTGHTRFNRVMRRKYQLDSAYYSETGQNRENVHDTPATMSHETVVAGMKNDKILDSEMQKHEVYDSQELLEKRQQSDTATGDQTTVSATVINVVDNNSQTSSGTSATAPTTISDESTVPATTDLSTESDSFSLSLSATISVEVPLTASPAYSSPTADTPAVTSTPEPSSSAPPSSAPASSKTSTPLFGSTATSLPSSTSIKPSSTVSDSNTSGTQNASQVTASSSGVVFSYGSQSTTTSSVSQTSSATTSIFSSDPTSTDSYYGAWTTASNGGGGGLGGTATGQAASETSFSSGSSGSGTNSTSSSGSSSGSGSLSTQTKGKIAGGVVGGVAAAMFVFVFVVWLLRRRRRNILPASGDALPEPDTTGTAEGSIPRSAEMASRRSSNDPLFTASYFAPAFMKRWRQSHMTTRTDDSTLSSEPSERGFQKISGRKIPSVLQSGGDGYGGGFEPGSPTASEPSTIFSPSSPVQPRSPATQPPLTTPYGMPLDASYTREAEESGGMVVFRPSPARTPVTSASASLSNEPGAPRIVSQVIVPGALSPTMPKRPDALGRSHPSFDGSRGSRFTESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFW1</accession>
    <name>A0A317WFW1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_105507</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466516.1">
        <property type="nucleotide sequence ID" value="XM_025605482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFW1"/>
    <dbReference type="STRING" id="1450535.A0A317WFW1"/>
    <dbReference type="GeneID" id="37107625"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000023">
        <property type="entry name" value="Putative ferric-chelate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF24">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016277820" description="ferric-chelate reductase (NADPH)" evidence="14">
        <location>
            <begin position="17"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="314"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY84591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="592" mass="66844" checksum="BAF64ED4EDA43098" modified="2018-10-10" version="1">MHSLLLCSSLVGLASAAELEKRHGGFSVYEMLNDDLARLSLMVLGLMAAFIYVWKMWHRLASHMRRLASFTNERQRYFVSPHGMLAKINNYIIYAPLFRTRHNREFQLSRAVNMGTLPSRFHSFLLVGIVAMNIVLCVVTVPYGSSETTVAGLIRNRTGTMATVNLIPVVLMAGRNNPLITLLQVPFDTFNLIHRWLARIVVLQSLAHVFAWAIPKAQKSGWDVIGMVFGESSFMLNGLIAACAFTALLVHSPSPIRHAFYETFLHLHMVLVALSFGFLWLHLDGMVSQNYLLVAVIFWALERAARIFIILYRNCGRESTTAHIEALPGDAMRITLKMTRPWAFHPGQHIYLYIPSVGWWMSHPFSVGWSEAEEFPAGEKGIPMTQQDLVSLKKTTISLLVRRRTGFTDKLFQRAQKSTGGRVSLRAFAEGPYGSIHTMDSYGTVMLFAGGVGITHQVPFVRHLVKGFAEGTVAARRVTLVWIIQSPEHLEWIRPWMTSILAMDRRREVLRIMLFITRPRNTKEIQSPSATVQMFPGRPNVDTLVGLEVENQIGAMGVLVCGNGSLSDDVRRVCRKKQDQTQVDFIEESFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH37</accession>
    <name>A0A317WH37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_102754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466472.1">
        <property type="nucleotide sequence ID" value="XM_025605467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH37"/>
    <dbReference type="GeneID" id="37107610"/>
    <dbReference type="OrthoDB" id="4510061at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY84547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="179" mass="20137" checksum="39534E56CE70E094" modified="2018-10-10" version="1">MADGLNQARALRVAEIINDYRTLLVHISQQNVQIPSEEANEEGYKAIREGLAAAQALMSSNYNPSMTPTQSNVETEKAELQRVILDASARRFQAHRIYLRVAAARRWAINRQNILRGQRAGPQHAAQLKTVSNTFRQEITQVTDQYVVADLRAADTRSGHWLADDPALPMILAWIRSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH83</accession>
    <name>A0A317WH83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aldo-keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_535971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466851.1">
        <property type="nucleotide sequence ID" value="XM_025611909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH83"/>
    <dbReference type="STRING" id="1450535.A0A317WH83"/>
    <dbReference type="GeneID" id="37114052"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF7">
        <property type="entry name" value="REDUCTASE (YAKC), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY85834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="328" mass="36213" checksum="5C854FDB08FF0FC2" modified="2018-10-10" version="1">MVKTLAFGDLQVPSPGFGAMGLSFGLGTNLSYEEAEPVLLKAIELGCTFWDTAVVYQAGVNEKLLGDFIRKHNVRDKVFIASKCGFDVFSGNGGVTNSASHIKEYIEGTIERLGFTPDLYYLHRIDPNTPLEESIPALDEIRKAGKTKYIGLSECSAATLRKANSIAKIDAVQAEYSAFETLHETDGLIETTKELGIAYVAYSPLGHGWLVDDFPFKTPDDFAPSDFRRTSPKFQGENFYNNKRIVDEIQKLASRKGCTISQIALAWVAAQGMIAIPGTTKVHRLEQNWASREVDLTEEEKEEMRKIIDAAKPHGNRYGPANQAMVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHA1</accession>
    <name>A0A317WHA1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">A49-like RNA polymerase I associated factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_566473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466750.1">
        <property type="nucleotide sequence ID" value="XM_025614555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHA1"/>
    <dbReference type="STRING" id="1450535.A0A317WHA1"/>
    <dbReference type="GeneID" id="37116698"/>
    <dbReference type="OrthoDB" id="532500at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009668">
        <property type="entry name" value="RNA_pol-assoc_fac_A49-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14440">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06870">
        <property type="entry name" value="RNA_pol_I_A49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY85733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="53709" checksum="38282F45A6FF4546" modified="2018-10-10" version="1">MPSDKVDKKRKRASDRHERPSKKPALELQDLPPLSSSVVEDDSELAPVIITTPGLSAPRNLRLNPYLKTRSKTSSASSRNKGIVSSELLLQSSEHPKLDFVGREAEEDADSQLKHYVAIVDPEKKTWQFVEVRKMTLRGSVRKMKAIEEEEEEESEEEEMKTMRAQRTELTNTFGTKQSRKAAQSLAENAQLSNVPAGAASAAENAILSAMPADAATDIASKTAAVQAQVQAAKPLPQANLDAAHPSDVYPIDVLVPNGLATLRQLPNIKEWQDTVNSGAAVNTTSRYVSRRVEAVALSGNTTHIQILRFILLLLELARCLRPGRDKSSGPGSKRLPPREDLRRILSGGTTNENAASGDQLPDPVIDAVRRKFAPQGASLSKNDITFLHTTICALSLHIPPQPAKDGGNSSAGGNSPNELATDPSDLRDDLRLDNVAITQYFRELGCRVDKPRESEFAKWGIKGGKAEAAARRVARLKIPVEFPKVSRGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHB9</accession>
    <name>A0A317WHB9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_536220</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466562.1">
        <property type="nucleotide sequence ID" value="XM_025611963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHB9"/>
    <dbReference type="STRING" id="1450535.A0A317WHB9"/>
    <dbReference type="GeneID" id="37114106"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="93"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="136"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="180"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="224"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="318"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="594"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="831"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="834"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY84637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="864" mass="96045" checksum="2B4AD9FC08F5BDA4" modified="2018-10-10" version="1">MKLDVKRQLFARSERVKGIDFHPTEPWILTTLYSGHVYIWSYETQSIIKTFELTDVPVRAGRFIARKNWIVCGSDDFQLRVYNYNTSEKIASFEAHPDYIRSIAVHPTQPFVLTASDDMTIKLWDWEKGWKCVQVYEGHSHYVMGLSINPKDTNTFASACLDRTVKIWSLGSPHANFTLEAHETKGVNHVDYYPQADKPYLLTTSDDRTVKIWDYTTKALIATLEGHTSNVSFACYHPELPVIISGSEDGTIKIWHANTYRLEQSLSYGLERAWCIAYQRGRQGVAMGFDDGAVVVKMGREEPAVSMDGSGKVIWARHNEVVSTVIKGGDASIKDGAPLSLPTKELGSCEVYPQTLSHSPNGRFVSVCGDGEYIIYTALAWRNKAFGQALDFAWGSKDNSNDYAIRESTTSVKIFKNFKEVSGGLDVGFQAEGLTDGVLLGVKGQGGIGMFDWETGNLVRRIEVDPKAVYWSESGELVTLACEDTFYVLRFSRENYINGLNAGEADEDGVESAFEVVTDINESVRTGQWVGDCFIYTNSTNRLNYLVGDQTYTISHFDQGTYVLGYLPRDGRVYLADKDVNVVSFGLSLSMVEYQTVVLRGDMDMAAELLKDVPQDQMNKVARFLEGQGYKEMALEVATDQEHRFELALGLNNLDIALEIAREANVEHKWKIVGDAALAGWNLALAQECFTNAKDVGSLLLLQTASGNKDGLRQLAEQASESGLHNVAFSTFWSMGDIDGCIDLLVRTNRLAESVLFAQTYKPSRAPALVAQWKESLEGSGKTKIARLIGIPPGCPDIAADDDLFPEWDEYIRLEKEGVVVPEPPSLESLIDVNADEEDAESAANGDEPEEEVEEAEEAEETEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHJ8</accession>
    <name>A0A317WHJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_494603</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466632.1">
        <property type="nucleotide sequence ID" value="XM_025609237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHJ8"/>
    <dbReference type="STRING" id="1450535.A0A317WHJ8"/>
    <dbReference type="GeneID" id="37111380"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000023">
        <property type="entry name" value="3-isopropylmalate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000003">
        <property type="entry name" value="3-isopropylmalate dehydratase small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01026">
        <property type="entry name" value="LeuC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01031">
        <property type="entry name" value="LeuD_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004430">
        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004431">
        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012235">
        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00170">
        <property type="entry name" value="leuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00171">
        <property type="entry name" value="leuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002458">
        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004016">
        <property type="entry name" value="PRK05478.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009116">
        <property type="entry name" value="PRK12466.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF9">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001418">
        <property type="entry name" value="ACN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="13"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="535"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY84707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="771" mass="83739" checksum="602817EA9BA64D58" modified="2018-10-10" version="1">MPGVDRKPKTLYDKVLDHHIVNEQEDGTLLIYIDRHLVHEVTSPQAFEGLKNAGRKVRRPDCTLVTVDHNIPTSSRKNFKNVDEFIEENDSRLQCSTLEENVKDFGLTYFGMGDKRQGIVHIIGPEQGFTLPGTTVVCGDSHTSTHGAFGSLAFGIGTSEVEHVLATQTLITRRSKNMRIQVDGELPAGVTSKDVVLHIIGVIGTAGGTGAVIEFCGSVIRGLSMEARMSMCNMSIEAGARAGMIAPDEITFEYLKGRPLAPKVDSAEWKKAVNYWSSLASDEDAVYDTTVLLDGKDIIPTISWGTSPQDVIPINGVVPGPDDFEDENRKLACKRALEYMGLTAGTPMKDIPVDKVFIGSCTNARIEDLRAAAKVVRGKKIASNIKRAMIVPGSGLVKEQAEAEGLDKIFTDAGFEWREAGCSMCLGMNPDILSPQERCASTSNRNFEGRQGAGGRTHLMSPAMAAAAAIVGKLADVREHVVSSPVLGKVQPKVDVQQTYEEPETEDELERIMDLPADNEPHTNSSAGGSSAGLPKFTTLKGIAAPMDRSNVDTDAIIPKQFLKTIKRTGLGSALFYELRYKDGAENPDFVLNQGIYRNSKILVVTGPNFGCGSSREHAPWALLDFGIKCVIAPSFADIFFNNTFKNGMLPVVISDEAALQKIAAEAHAGREVEIDLVNQEIKDTQGAKLASFDVDGFRKHCLINGLDDIGLTLQMEDKIRTFETKRTLETPWLDGSGYLKRGNCGGATMVQAAPVPKTNRGDVKTEPLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WIW3</accession>
    <name>A0A317WIW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_535550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466987.1">
        <property type="nucleotide sequence ID" value="XM_025611812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WIW3"/>
    <dbReference type="STRING" id="1450535.A0A317WIW3"/>
    <dbReference type="GeneID" id="37113955"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY86396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="276" mass="30993" checksum="44837A38E833AD23" modified="2018-10-10" version="1">MIQPRLLAPLRALERSIPSILRTTTPRTALNLNTTLLRTTLSTPTPLQQQIRQASHATQGTANRHSRDPAGKRLGAKRTSGEYVVPGCIIFRQRGTKWFPGENCAMGRDHTIYAAEAGYVRYYLDPERHSERKYIGVVFEKDGKLPVPRNAPSRRRLGRVNVKFEVEGEGVQKKEEGDLVAEVGVGKKVEDGGVVVGSVAKEEMQTDGGVQLRPGYMYREANWVIGRAAEKAGITAKVYRRKNRWLAWRKRTAKSERMAQMKSLKNKKKGAKKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ82</accession>
    <name>A0A317WJ82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase, H3 lysine-36 specific</fullName>
            <ecNumber evidence="4">2.1.1.359</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">SET domain-containing protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_467388</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(36)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60324"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:15536"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.359"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.359" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466718.1">
        <property type="nucleotide sequence ID" value="XM_025608203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ82"/>
    <dbReference type="STRING" id="1450535.A0A317WJ82"/>
    <dbReference type="GeneID" id="37110346"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140955">
        <property type="term" value="F:histone H3K36 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19172">
        <property type="entry name" value="SET_SETD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1740.100:FF:000002">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000033">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1740.100">
        <property type="entry name" value="Set2, Rpb1 interacting domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025788">
        <property type="entry name" value="Set2_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044437">
        <property type="entry name" value="SETD2/Set2_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013257">
        <property type="entry name" value="SRI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038190">
        <property type="entry name" value="SRI_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08236">
        <property type="entry name" value="SRI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00570">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51568">
        <property type="entry name" value="SAM_MT43_SET2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="20">
        <location>
            <begin position="160"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="18">
        <location>
            <begin position="217"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="19">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="17">
        <location>
            <begin position="607"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="537"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="665"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="782"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="592"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="782"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="824"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="869"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="909"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="926"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY85701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="952" mass="107166" checksum="21762FC94AEF4FAA" modified="2018-10-10" version="1">MSPHDYADHQSESVADAVTAMKLESDISPEISAVNGGGTMIKDESSNAASNASPIPTPKEQSRLSSRSPAKKEESEEDEQNSTGKDDNHVDKLEERVGGDIIVKLEPGQPPKLTRSSSQKVVARPPQFFSHLPDSTAEAEATFDLLDACTYANKFMGYTEHAMECDCAEEWEPSVSKNLACGEDSDCINRATKIECMGDCGCGPECQNQRFQRREYAPVAVIKTEKKGFGLRAEADLRPHQFIFEYVGEVINEAQFRRRMRQYDEEGIKHFYFMSLSKGEFVDATKKGNLGRFCNHSCNPNCYVDKWVVGEKLRMGIFAERHIQAGEELVFNYNVDRYGADPQPCYCGEPNCTGFIGGRTQTERATKLSNATIEALGIDDADGWDTAVAKRPRKKKMGEDDEEYVDSVQPKSLEENGVTKVMAALMQCKEKWIAVKLLGRIQRCDDERVRNRVVKMHGYQILNSQLGMWKDDFNVALQILDILDKFPRLTRNKIIDSKIESTIQPLTSCSDERVEKKAAMLLQSWSTLEVGYRIPRMKRDPNATTPAVNQFERREITRDERRRSKSRSRSRSRSIEAPRGPAAQARGGHGQRNTHHHGPRPFRRQFNPLPPGWFAAESNGRTYYYSARGDTTWTRPTKPAPQPPPPPKESRDKALQDIIDGIMNAKENTPKEKTGTPVTPQASRPTPDSKDGQEKWRTYSEEKRKKIYENTLYPHVKYVVDKFKHKLPKDDLKRYAKDVAKKLVNSDFKNNRVGDPTKIDDKQQKKVKKFCKEFFDKAVAKHRAYEQRKTERQSKGADLKPDVEDEALDVKMSDDEDDRAPAQAQETPTTMTDELQGNLKRKREEPSTGDGSTTEYTTPSSSKRQRSSTPPPPPPPPMSPGNELAQSGDDSNMKSDTDEPTPADKPLFDSPPPPPPPPPFPGQNFDSEENDFNGEEGVGELNPSQIGIEGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL33</accession>
    <name>A0A317WL33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_535907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466784.1">
        <property type="nucleotide sequence ID" value="XM_025611893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL33"/>
    <dbReference type="STRING" id="1450535.A0A317WL33"/>
    <dbReference type="GeneID" id="37114036"/>
    <dbReference type="OrthoDB" id="5530243at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="2">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY85767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="167" mass="17495" checksum="30352267D1602B6E" modified="2018-10-10" version="1">MTTSTSNPTTTTTTTTTSTSTPTKRKSSTSESTPKTIHFAARTPTWTYLKLISINHDITSTTPTLDPLTARTYLSAALSQFLGLTGTAIPIDILKVSTEHRTPTVWTRVPRDDASAVVAALSSWIGGSTNTGGGSDTSAGNVAWRVCAKGNYLGALVQGSGSELFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMY6</accession>
    <name>A0A317WMY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_585316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467617.1">
        <property type="nucleotide sequence ID" value="XM_025615688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMY6"/>
    <dbReference type="GeneID" id="37117831"/>
    <dbReference type="OrthoDB" id="4504027at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="99" mass="10817" checksum="E9B48084A9B19CE6" modified="2018-10-10" version="1">MCHVQRVLNTCGHINDHVFLACHIAKAAAALLAPSDINGGCDSFQPQFLKNFPAGTIWERISTTGYHAVTQPYCTDGRVYCLRSPRGFKCMVDGCGRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNC2</accession>
    <name>A0A317WNC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_624094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467737.1">
        <property type="nucleotide sequence ID" value="XM_025617195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNC2"/>
    <dbReference type="STRING" id="1450535.A0A317WNC2"/>
    <dbReference type="GeneID" id="37119338"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="349" mass="37925" checksum="DF0A2E132C846514" modified="2018-10-10" version="1">MSSSQVTHRRAFRRTDDYTPGNPKLKLVVEELPLPLAPTAVLIKVHALALNYRDANIANGGNPWPVIPNGILCNDAAGEVIAIGDKVKTFVIGDRAAPITDTENISGRETKRSWLAADEDGVMADYIVFDERVLCSLPYYLQWVDAATIPCAGVTAWSALKGMSIGQTVLIQGTGGVSVFALKLARAAGLRVILTSSSDEKLQQMKTKYSSPPVLTVNYSQTTDWDQEVLKLTDGVGVDIVVENGGTGSLVKSLRCTRRGGTVSQVGYLSKQDPSDLRELVPTLIDRRINLRGINAGSKHDMEDFCAALSASQMPLQDLVDKVFPFEQAEDAVEYIWQGKHIGKIVLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPQ0</accession>
    <name>A0A317WPQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_624300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467295.1">
        <property type="nucleotide sequence ID" value="XM_025617206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPQ0"/>
    <dbReference type="STRING" id="1450535.A0A317WPQ0"/>
    <dbReference type="GeneID" id="37119349"/>
    <dbReference type="OrthoDB" id="4482539at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY87087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24660" checksum="158488F32FAE64A8" modified="2018-10-10" version="1">MKHWIKDLVSQPQSSQLLTTTTTDDSFAITSNNQTYTPRKRTGTCFLLILAAMVVWLSGIVMGILLAQTNALRPNQAETAPTSTIPQMIITTHTTQKVQHNPAFEAPPPTGGGAEPYLIRRAYYAPHNPHSNPSSEEKASFDTGVDRPPHVGHCFDYLRQSLICTADSRLEPATQKANGNPTWGFERVCWDFEEVKNWAGKWKAYDISGSFVPFSVEDHHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPR2</accession>
    <name>A0A317WPR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kinesin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_546339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467305.1">
        <property type="nucleotide sequence ID" value="XM_025613288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPR2"/>
    <dbReference type="GeneID" id="37115431"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11557" checksum="7584088C340BA41D" modified="2018-10-10" version="1">MQKLAFTLKQLGKAPDALNLLRRCVDLRINILGSHHPHAISSSNTLRDWETAAVQPSKCQQPHASLPGSSHLNPMHAAANIHPTSASKPVGRKRRFFMSLFSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQG1</accession>
    <name>A0A317WQG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_574703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468031.1">
        <property type="nucleotide sequence ID" value="XM_025615035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQG1"/>
    <dbReference type="GeneID" id="37117178"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY88669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="298" mass="34111" checksum="791227D5572C6E24" modified="2018-10-10" version="1">MTSPPTSSYVMTKPDENDEKDRLDLQHEIWLLALQNRLHTTAFTHPPKTILDIGCGTATWALSMAEVHPEATITATDLHRPPKLTATTLSSSPNLRFSQFDADDLIWPFPEHTTFDFIHGRMITSGIHNWPRFLTHCSSLLTPGTGRLELLDVSHPFRAENAAADGEALSPFIRFGYAMERVWAANGIDYRATEKHALRLKELGFQDIVMEEVRWPLGPWVHTSEREMELGRLNLENFGRFIRTAGVNLLMSGDDNGEEREKRMAEAQRLVDDAVRDLEDDWDTNRYYLSMKIHRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQL1</accession>
    <name>A0A317WQL1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 25">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="4 25">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BO94DRAFT_491140</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="4 25"/>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468048.1">
        <property type="nucleotide sequence ID" value="XM_025609148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQL1"/>
    <dbReference type="STRING" id="1450535.A0A317WQL1"/>
    <dbReference type="GeneID" id="37111291"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 25" id="KW-0288">FMN</keyword>
    <keyword evidence="11 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="15 25" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14 24 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 24 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="PWY88686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="728" mass="81135" checksum="D6ADC89D454C2713" modified="2018-10-10" version="1">MEPTTANLEANAPKRDPQNGDSAADQAQEPPSKRARLDDAAGPSVQAADAPAPRVKGVAPIKAEFIIDQPTRSQPAPETNADDAAEAAHHDGRADEHKGVKKNKKKTGQNTNRKFGRSEDAKGLCSSVNFRPEFSPAECTFGEKCRYEHNLRTYLKEHKREDLTTFNGLCPVWDINGKCSEGYKCRFLGSHMEERDTADGRKELVLVEDEERKKKVQRLVPFATDGVVNIASVEEKVALARRKMDFPRAGPYSDWLENTARTMEKELHKRNRGGVESAESKDGESKDEKEAKEDNRAIYVEPPFLPSEKRRLYFGPETPALAPLTTQGNMPFRRLCVELGAQFTYSEMAMSLPLVQGNKSEWALMKAHESEMLPPTLLPGADIVQGYDNSKDFKFGAQIAANKPWQAFKATEALAKVTPNLRVIDLNCGCPIDLVFRDGAGSALLEHPAKLEKIIRGMNTVSEHIPITVKIRMGTKDNSPNALKLTERLLLGGYETSLLHHDGAAGAAAITLHGRSRQQRYTRSADWGYISECAALIKRLGEKTDAVTDTVREPDARTQPNGGKVFFLGNGDCYSHVDYDEHINNAGVDSVMIGRGALIKPWLFEEIQAGQYLDKSATERLAMVEKFVKYGLETWGSDEHGVGTTRRFLMEWLSFTRRYIPIGLLEHLPPSINDRPPAFRGRNELETLLASANYKDWLKISEIFLGPAHKDFKFEPKHKSNSYDEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSF3</accession>
    <name>A0A317WSF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Velvet complex subunit laeA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_47059</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-methionyl-[protein] + S-adenosyl-L-methionine = S-methyl-L-methionyl-[protein] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:60560"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:15592"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:142742"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:60561"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468023.1">
        <property type="nucleotide sequence ID" value="XM_025608344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSF3"/>
    <dbReference type="STRING" id="1450535.A0A317WSF3"/>
    <dbReference type="GeneID" id="37110487"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF30">
        <property type="entry name" value="PROTEIN-METHIONINE METHYLTRANSFERASE LAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0749">Sporulation</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY88661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="377" mass="43161" checksum="B41F4F533E7017D8" modified="2018-10-10" version="1">MFANGNGRVLHQPITMASPPHNHYASHSAGSSDIGRSRQNSDAMDIYVITDREPPGDDPAGSEQWDRNESPGSSSSPSSNRSPDRLAFHEENGRTYHGFRRGVYMLPCDEQEQDRLDIFHKLFTEARVSGSLIYAPHPTNARILDLGCGTGIWAIEVAQKYPDAFVAGVDLAPIQPPNHPRNCEFYAPFDFESPWALGEESWDLIHLQMGAGSVVGWMNLYKRVLTHLRPGGWFEQVEIDFEPRCDDNRLEGLAIRYWYQYLKQATQDCMRPIAHNARDTVRDLHEAGFTEIDHQMVGLPLNPWHKDEHERKVARWYNLAISESIESFSLAPFTRVYDWPLDRIRHLAAQVKSEAFNKEIHAYNILHIYQARRPVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTN4</accession>
    <name>A0A317WTN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative phenylalanine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_593983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468366.1">
        <property type="nucleotide sequence ID" value="XM_025616190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTN4"/>
    <dbReference type="STRING" id="1450535.A0A317WTN4"/>
    <dbReference type="GeneID" id="37118333"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="685" mass="75097" checksum="02AA1E8FD8887941" modified="2018-10-10" version="1">MESHLSHLQKTWQLVERLTGSNCHVFLDGDSLSLGAVVAVSRSLAKVSVHDPEQLAQRLDEGAKTLTRLLDRNEQVYGVNTGCGSNADTRTEQLRILQHSFLQHQQCGILPDMASAGLSAMEENSHSLPSDIVRATILLRCNSLLRGHSGVRIKIIDLLLYALNEDITPVVPLRGSLSASGDLSPLSYIGGLIEGSPDVYVRMKENGKARVMTAETALQQANIRPLSLNAKEGLSIVNGTAVSAAAASLVLYDSHNLALFSQVLTAMATEALLGAVDNYHEFISKCRPHPGQTEVARNICSCLRGSRLPQDTDVNKLGLVQDRYALRTAPQWIGPQLEDLLTADRQIDIELNSSTDNPLIDVSRDRFHHGGNFQAASVTSAMEKVRGALVMLGKILLGQCNELINPFQNGGLPPNLCADDPSLSFAVKGLDVHMTAYYSELAYLTNSVASHVQTAEMGNQSVNSLALISARYTGQSVQLLSMMCAAHLYVLCQALDLRALSLDFFATAKTETSDMYCKIFITDEELDSSQFENVWFQIESTWLSTAQLDLSDRCEKVAAQSVAYLMNERFMGPTTPSPQFCSSIKRWRERLSCLLCDLYNHTRAGFTKSPSTPSYLGEVTRSTYEFVRHKLAVPFHRGVSDHPTIIGNSATGESKKTIGFHVTRIYVAVENGDLMKPIKPILKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTP5</accession>
    <name>A0A317WTP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Histidine biosynthesis trifunctional protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-AMP cyclohydrolase</fullName>
                <ecNumber evidence="19">3.5.4.19</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Phosphoribosyl-ATP pyrophosphohydrolase</fullName>
                <ecNumber evidence="19">3.6.1.31</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="19">Histidinol dehydrogenase</fullName>
                <shortName evidence="19">HDH</shortName>
                <ecNumber evidence="19">1.1.1.23</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO94DRAFT_515487</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 19">In the C-terminal section; belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="19"/>
    <dbReference type="EC" id="3.6.1.31" evidence="19"/>
    <dbReference type="EC" id="1.1.1.23" evidence="19"/>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468014.1">
        <property type="nucleotide sequence ID" value="XM_025609923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTP5"/>
    <dbReference type="STRING" id="1450535.A0A317WTP5"/>
    <dbReference type="GeneID" id="37112066"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11546">
        <property type="entry name" value="NTP-PPase_His4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1080:FF:000002">
        <property type="entry name" value="Histidine biosynthesis bifunctional protein HisIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1300:FF:000001">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.810:FF:000002">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000050">
        <property type="entry name" value="Histidine biosynthesis trifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1080">
        <property type="entry name" value="MazG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="entry name" value="Phosphoribosyl-AMP cyclohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016298">
        <property type="entry name" value="Histidine_synth_trifunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF2">
        <property type="entry name" value="HISTIDINE BIOSYNTHESIS TRIFUNCTIONAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001257">
        <property type="entry name" value="His_trifunctional"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101386">
        <property type="entry name" value="all-alpha NTP pyrophosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="HisI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16 19" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 19" id="KW-0520">NAD</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphoribosyl-AMP cyclohydrolase" evidence="21">
        <location>
            <begin position="221"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="394"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PWY88652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="869" mass="92626" checksum="EE55A97B7C02A00F" modified="2018-10-10" version="1">MATPLLVSYDPASPSSSLSLKQIAYFGRVLIKASSLAQTEEFIKHNFRLLDVYVDATAISSSGDLVDILNAGAAKIFISLDQLTALSEEQSVPSSRLVVYTSESQVDAFQTWVGQSTERKDAGLSTDASAVKALAEKLGMNLEAQNLYRTYSSTPSEEALKDTLNQGGLSVVSADALTFEHKEPNGKIVAASLIAARAVADQSNGLYATTVTDERGTCLGLVWSNDESIAEALRTGTGVYQSRKRGLWYKGQSSGDVQELIRVGFDCDSDCLVFVVNQVGRGFCHLGTASCFGPYNGLARLQKTLQARKADAPAGSYTARLFNEPKLTQAKIMEEADELCRANTKEEIAFEAADLLYFALTRCVAAGVSLEDVERNLDLKSLKVKRRKGDAKGPWAEKAGLAAAAPESKPAAEPAPPAQPTPKADETMQMTRVVTALTPVEVVQDYLKRPSQKSNDAIVALVRPIIQDVREQGDAGVLKYTHKFEKATSLTSPVIRAPFPPELMKLTPETQEAIDISISNIAKFHSAQKDSNDGLKVETMPGVVCSRFSRPIERVGLYIPGGTAVLPSTAMMLGVPAMVAGCKKLVFASPPRADGSISPEIVYVAHKVGAESIVLAGGAQAVAAMAYGTESISKVDKILGPGNQFVTAAKMLVSNDTSAGVSIDMPAGPSEVLVIADKDANPAFVASDLLSQAEHGVDSQVILIAIDLNEQQLQAIEKEVDIQAKALPRVDIVKGSLAHSVTFVVRDLDEAMALSNDYAPEHLILQIQDAEAAVAQVQNAGSVFIGEWTPESVGDYSAGVNHSLPTYGYAKQYSGVNLGSFLKHITSSNLTAQGLLGLSRTVEQLAAVEGLDAHKRAVSIRVAHMKQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW15</accession>
    <name>A0A317WW15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Formate/nitrite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_534094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468982.1">
        <property type="nucleotide sequence ID" value="XM_025611459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW15"/>
    <dbReference type="STRING" id="1450535.A0A317WW15"/>
    <dbReference type="GeneID" id="37113602"/>
    <dbReference type="OrthoDB" id="4829at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000011">
        <property type="entry name" value="Formate family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024002">
        <property type="entry name" value="For/NO2_transpt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01006">
        <property type="entry name" value="FORMATE_NITRITE_TP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY90604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="309" mass="33631" checksum="690BA2D90423BD71" modified="2018-10-10" version="1">MSVNLDAYTPAEVIEFVARAGAAKGNMRLDKVFFSAVSAGCLLGLACGTSLSTNTSSWFQENAPGLIRTIGALVFPYGLCMIILTGADLCTGSFMYTTVAALQRQLPWYKMLLHWFVTFWGNLCGSLFLVAIIFGYGEVFSTDPYKSEVIAYATKKQVTPQFQQIFLRGIGCNWLVCLACYFGIQGRDLASKIIGIWWPIFGFVSLGFDHVVANMTFIPLAIWLDAPDITVGLYIWKGIIPTLLGNIVGGGLFAGAYYWYMYLLPGETMSLAALRRRQQQQSAGSSEVTATAGGKDDVEASAGVLEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW76</accession>
    <name>A0A317WW76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_584680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468328.1">
        <property type="nucleotide sequence ID" value="XM_025615643.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WW76"/>
    <dbReference type="GeneID" id="37117786"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="910"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="952"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="995"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1096"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="272"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="591"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="877"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1192"/>
            <end position="1426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="809"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="809"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY89417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1430" mass="156929" checksum="875DCE7AF69A7571" modified="2018-10-10" version="1">MAGCQDNSFGPYAGPECRGGFDFTLKFEEIVMTLVPATIFLLVATIIIICLLWTRGSVGAGVGFDRLSIAKRMASGMLCIQSLALLVCARYQTAAVTRLMLATTAVLFVENVALAAWSTLEHQRSAHPSLALNTYLVCMVLLQACRVRSLWLADTPLDLSILTTTSLATRLALLTLESVDKPRPEETKGSPNLLEDRGSFPSRVFFGWLVPLLRQGYSGILSAVDFSGLETDRTQQERQRRFTAAVERRRGTPASKFHLITILIYCNPADFVGAIVFRLSYIAALFAQPFLIQDVLNFLEDGSMPLNRGYGLIGAFGLIYLFIAIFTAHYAHCTNRFALGSWALLVNGVVDATLNAPVATIPQPGKVGAAVNVDAANTVQGFRAMHDLWASFVTVALCLWLLYLQLGLAFVAPLLSTIVFTALTVSVSPIMIRRQRSWVEATERRLGVIIRTISSIKEIKMMGLGSRMEQSIQQLRRDEVRMARYEAVSTHDISHPAGSYQGATFVTYGAFAIICRVTGTTLNTYNLDMSLSVLSIMTSPLYLMIQQAPVVVAGLNSLQRLDAVLKLPRVPNTPAQDVNCVAGPIEDKALITLQEATLDWDGNSPVLEDVNLQVFSGQFHAIVGPTGSGKSTLLRALLGELNPIRGVIRKRVSGGIAYCAQKPWLMNGTIRSNVIGTGPFEPSWYQQVLFACDLDKDLASFPQRDQTSIGSAGVALSGGQKQRVGLARALYARSELLILDDILGGLDNTTQHNVIERVFGAQGVARQACTTTVVVTHHATLISLMDTCLLCGDGRVEAQNSSTALHKLQRVESADTLDEKTESHDQEASSSMSHQAEGQYVAEGVEQAETEDQPKRSDPESWRLYRYYMQLVGNHHTLLFIILSATVAGVSVYQQYWLTDWADAESNRQLSMYITVYLGMLVATLIVIFGWCSHFLDIMIQKASLQLHEAQLLAFLRAPISFLMAAKSGALANRFTQDIMLVDDELPLALLNTVSSFFSVLAEVVVVFVACPIMAAVTPALFIVFWVLQSFYLRTSRQLRVLEIEAKAPLYQHTLQCAEGLATIRAFGWTAAQQTESTRYVNSAQEPMYMLYSVQVWLKMVLDLIIAGVCVLFAGLVVKLRSSSEAGMIGLGFISIITMSTTSRRFMVAWTTLEISLGALSRIHSFVTDSPSEDASSGSAQRPTVWPTEGKVEFSNVSATYTAQGRPVLSDINLTIHPREKILICGRSGSGKSSLVSSLLRLLHVSSGTIRIDDLDTSTMSVASVRSALTVLPQDPFFISGSIRDNMNLGTSVSSDEQIQAALRKVGLWTYVEKELGGLESTLDPKMMLSQGQQQLFCLSRMILQKGKIIIIDEASSSVDNDTDARMNAIIRSELDDRTVICVAHRLDHLLDYDRVVVLQSGRIVEVGEPKALLQRPSMFQELWQSMHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWN9</accession>
    <name>A0A317WWN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ZIP zinc/iron transport family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_22325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468689.1">
        <property type="nucleotide sequence ID" value="XM_025606230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWN9"/>
    <dbReference type="STRING" id="1450535.A0A317WWN9"/>
    <dbReference type="GeneID" id="37108373"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000006">
        <property type="term" value="F:high-affinity zinc transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071578">
        <property type="term" value="P:zinc ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF32">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY90311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="353" mass="38702" checksum="40FD046F70DB389D" modified="2018-10-10" version="1">MPSFDPTNVNLDTASVEDIYCYLQLSENDYNGQLGARISSIFVILVTSSACTLFPVVAKRIPRWNIPYPVYLFARYFGTGVIVATAFIHLLDPAYENIGTTTCVGVSGHWADYSWCAAIVLASVIMVFLLDVASEVYVERIYGVEREHDATDRFLIQASLIQSDDEYAVGGNSSGRKQPGSQETLSVESERSFRQDIAAFLILEFGIIFHSVIIGLNLGVTGDEFATLYPVLVFHQAFEGLGIGARMSALRFGQHRWLPWILCMAYGLTTPISIAIGLGVRTTYNSGSKTANMVQGVLNAISAGILIYSGLVELLARDFLFDPDRTKRRSHLLGMLLCVLLGAGIMALIGKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYU8</accession>
    <name>A0A317WYU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_513821</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469294.1">
        <property type="nucleotide sequence ID" value="XM_025609857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYU8"/>
    <dbReference type="STRING" id="1450535.A0A317WYU8"/>
    <dbReference type="GeneID" id="37112000"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000035">
        <property type="entry name" value="TrmH family RNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="11">
        <location>
            <begin position="171"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY91566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="493" mass="54360" checksum="8C35119B141B1CB4" modified="2018-10-10" version="1">MSLHSSLVPLRLYLRSSVAPAARLHSIRHASLNSAIGRGIRRSHPVDGPRKDRRDRNMDRDGDSRPPRSGYKDTREPRRAEVEFDEDEFIRTGNFRALPRVHQRFENTRSSSRMNDMSRTRDTRDMPRTKDNGHPKDRTAYHRTTEKVPVRVKENVLVPDSIPYTTPASEFIYGGAAVEAALRCSRRKLYKLYLYQAAGEELSSSKIALRKLALSKNVAIKMAFAGWDRLLDKMSAGRPHNGCVLEVSPLPQLPVKSFKTVSSAEENHFSLELGVQSREEAQVNGTNDRIKINHSLRNRYPVVLLLDGIIDPGNLGAIIRSAYYLGVEAIVFAGRNSAPLSPVTIKSSAGAAENMTLLHVRNEVEFIQRSKTNGWRFYAADAPGPGSTLIDPSSLWQTSSTGDGSSASEGPLAQSPSVIMMGSEGTGLSSHIRSQADAIVSIPGARISTELGVESDPARVDSLNVSVAAALLMDMFLRMPFAMADMPKKGKLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYW5</accession>
    <name>A0A317WYW5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_533723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469312.1">
        <property type="nucleotide sequence ID" value="XM_025611385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYW5"/>
    <dbReference type="STRING" id="1450535.A0A317WYW5"/>
    <dbReference type="GeneID" id="37113528"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045329">
        <property type="term" value="P:carnitine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF25">
        <property type="entry name" value="OXIDOREDUCTASE AIM17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="247"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="540" mass="61647" checksum="36AE92A2314C8B40" modified="2018-10-10" version="1">MARLLRIPFRLPRVSASSASTLCRRVYSSTGAVPPAGAVPPAGAGAPSAGAPLAGAAPPPSKSTAPVDTDPESLANPNKRPATDTESTEVLGPEEPITLTERLLQTPGIDLEEIGEVEYRDDKYTVLRTKKGLVIDEVGRRPIEIEDIVLRDACKCPVCVDPHSKQRNFRTSDIPTTIKASEPKVVRGKLRVLWQNDFMEESGHYSTYDLYNLQFPIVNPAEADAARKFRWRAFWDKRRMEHWQHWITFEDFMNNDIAFAWSMRTLAELGLIFVKDIPDSREMVEKIATRMGPLRNTFYGPTWDVRSIPQAKNVAYTNQFLGFHMDLMYMNEPPGFQLLHCLQNSCEGGESLFVDTFRVAYDMKKEHFPYYDILSKVKVHYEYNHEDHFYTNKWPVFELKRSKRKTRDGEVVKHALTHVNYSPPFQAPFQVKSFGTHKLPKFTNALKKFSDGLEDEGNMFELKMKPGECVIFENRRVAHARRAFGTDTGQRWLAGTYVDEDAMLSLFKTSANKYPNLWTYKRKGLNSKHVKLLKGIPTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ17</accession>
    <name>A0A317WZ17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bicyclomycin resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_564939</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469362.1">
        <property type="nucleotide sequence ID" value="XM_025614462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ17"/>
    <dbReference type="STRING" id="1450535.A0A317WZ17"/>
    <dbReference type="GeneID" id="37116605"/>
    <dbReference type="OrthoDB" id="9986881at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF138">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="70"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="992"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1004"/>
            <end position="1035"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY91634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1035" mass="113328" checksum="8F5A2D12C317C339" modified="2018-10-10" version="1">MNHPQSSDTSSEGSQIKGDVEKNPGRLLSMGKGKVFPPLLPNREDYVVGFDGPDDPEHPFSWAISIKLYVSIMVCFGTFTASFASAVFAPGAGGAAKAFGVSSEVGMLGTTLYVLGFASGPLIWAPASELIGRRWPLTMGIVGVGLFSIASAVAKDIQTVIICRFFAGMFGASQLSVVPAVLSDIYNNMHRGAAIAVYSLTVFVGPFSGPFVGGFLASSSLGWRWTLYIPAFMGFACAAMFVLFLKETYAPCILVSKAAALRRQTSNWGIHAKQEEVEVDLQELVQKNFTRPLRMLVTEPIILVISVYMSFIYGLVYALLEAYPYVFESVYGMSPGVGGLTFCGLIIGQLLACGFILSQHSVYVKKLAANDNIPIPEWRLTPAIVGAPVFTAGIFWFSWTGFTPSIHWLAPTAAVVLIGFGILCIFLPCFNYLVDSYLPLAASTVAANIILRSSVAAGFPLFAKQMFANLGVQWAGTLLGCLAAIMIPIPLLFRLYGPRWGYDCHYSRHTRPRPSTPSHPDSDPVPVPDDSPAAAARVAESLEANSGAAFVRKVALKVDPVNAPKLNLFGWNVGKRKSLAPGASADKPIDDICSATTLQTLGRRYFAKIDPCYGFIDSVQFFRRMDARWQPFAEESTYDGVLAGVAALGALFSDTEMDRVESSLVELARHISDTHLGSAPPSLDLLTVWTLRVVYLRMAAPPYPAWVASSTLMHLIEASKLHQVSSDERDLDIRRRLIGVAQHLNIWISYDLGLSRVSLSTDTLGLPTPRPGDFTVELLGLLPLTASLGPENQRHDQEIEQLLLQTLDRTHTIPPSLLAQCNLTFCLLRRLRLTNVTTTPTTMKRVIDLLKRSLAAARDMATNHSPWQHVANVPFHMISILLEMDTSAALELLPDAMQTLKLVASTYDTDTMREAYSTAYLFINLYEKRRIADTRLLTRPPSGLNEISWVEGVMADVPTLQGLDFEQFLQPDMLRLSPDNLCNLINPSPLITKHPKPYQHNQPLQPPYPTPQPDNQKPPPTAPPPPYDYTPNSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZM1</accession>
    <name>A0A317WZM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_461712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469562.1">
        <property type="nucleotide sequence ID" value="XM_025607947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZM1"/>
    <dbReference type="STRING" id="1450535.A0A317WZM1"/>
    <dbReference type="GeneID" id="37110090"/>
    <dbReference type="OrthoDB" id="2999773at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="199" mass="21992" checksum="3DC14D06FC3DD10D" modified="2018-10-10" version="1">MSSNPREAPSPRTAPPPPPPPLGSDRESTLLAAPRPPIVAGTGPAGAFMVQLLIYNGHPFKDHWAYWVCSHASPDYGVMIHATGDVRNGFKFEVKRGHDFRATQNPPSKRIPLQWVSGEYFDEGTILNNGQYKIDNDPVCGFEASAHKVKAPGKSLNTTDSKKVTQRNCQTWIVESADQLVRDNIFDKDVADYLHAIQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZS7</accession>
    <name>A0A317WZS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_461761</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469591.1">
        <property type="nucleotide sequence ID" value="XM_025607949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZS7"/>
    <dbReference type="STRING" id="1450535.A0A317WZS7"/>
    <dbReference type="GeneID" id="37110092"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="45"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY91863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="418" mass="47576" checksum="A08B4E91D86F69C2" modified="2018-10-10" version="1">MFLNEEDPGGRQFQYNWIDGVESLEKYRPGGFHPIMIGDVLRGRYRIIDKLGFGGYSTVWLALDTCLHRYIAVKVGTANSPMQETKILRALSNPGHDSIPTPLDEFKLDGPNGTHPCYTMIPARCDLREVSFSRLFPLEVTRALSGSLILAIAYIHSRGYVHGDIHLRNILVKLPSGFNHLSVEELYEEYGEPEIVSITRCDGKPLLSNTPSKAVLPLYLGKGAEEFSLSDTHILLSDFGEAFAPDLETRCGKDCHTPLAMQPPEARFEPQAPLSYSADIWSLAIAIWEILGMQPIFCNAYVTADEIVSQQIDVLGPLPSDWWMRWQERSQFFDSNGNPKEGRYVWPGIEMAFEDTVQKYRRKRGCEFDTEETTAIIDLMRRMLVFRPEERLTIQEVLQSEWVVKWALPQLKRDSQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X068</accession>
    <name>A0A317X068_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DSC E3 ubiquitin ligase complex subunit A</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Defective for SREBP cleavage protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase dscA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BO94DRAFT_564891</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the DSC E3 ubiquitin ligase complex composed of dscA, dscB, dscC and dscD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469289.1">
        <property type="nucleotide sequence ID" value="XM_025614457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X068"/>
    <dbReference type="STRING" id="1450535.A0A317X068"/>
    <dbReference type="GeneID" id="37116600"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000626">
        <property type="entry name" value="Transmembrane ubiquitin ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="24" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016381939" description="DSC E3 ubiquitin ligase complex subunit A" evidence="22">
        <location>
            <begin position="23"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="733"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="480"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PWY91561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="803" mass="90464" checksum="BC201C12E80401F9" modified="2018-10-10" version="1">MDHRGSFFFFLVVFYLLLSSQSHSPLVSQDREHQRELAREHNALRMLNESKYGDFDPAADRWLPFSGVRKNDSYAWDLLPDVQDRARLQLRSTMTEAGLRPPKTLAVPDAFPDLNLTQLLLPVYRNATGKLRGEWVRRKQDKEHPPLNTTAIVLENEYFTHEFSHNITGESGTFYLDLREGGGEELRLPHGHVREIRATLAVESGDFWGNTWYLSLFGVHFPETGSIILSTTSEKFGGVFSLPHLALSSDAYNLTHQLLIKSLSDTISEKQNRPPTLFPWSSLVGTEQMEYPAPKCEHIVYLQQHPVAIHGYLADKDIIEQLEQELRYPMGAPIPSPPLLVMSAVVFSPDCGYVLETKGTPDFPPTDALYLSGPKLEEFGKYSARIIFVISAFSVAQIALLLRQIKEASTPSTRSRVSFYTIALMAFGDSFVLVFMLLELYPAVSFLVMTTASFLAFLSVSYIGMKFMMEIWAVQAPERREQDRRPNLSTTPRTGNLPLPATTARVSDTGATPIILTPDQDPPAEEDEPPANPGTAPTARDTRGDVGAMYARFYFTLFVLLILSIWSFLWPNRMGAIYARALGFVYLSFWVPQIYRNVMRNCRKALRWDFVVGQSFLRLFPFIYFLTARGNVLFIRPDSTTALALAGWVWIQVWILASQDILGPRFFVPRGWAPPAYDYHPVLRDSAGSADDLESGGVLPIGALRADEREFSSEAKDEDKQRAKDKKKAIFDCAICMQEIEVPVLAAPRGSGGSSVTDGATSLLSRRTYMVTPCRHIFHSTCLESWMRLRLQCPICRESIPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1T7</accession>
    <name>A0A317X1T7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469245.1">
        <property type="nucleotide sequence ID" value="XM_025611368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1T7"/>
    <dbReference type="STRING" id="1450535.A0A317X1T7"/>
    <dbReference type="GeneID" id="37113511"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="524" mass="58338" checksum="F029BE2ACC8CD14C" modified="2018-10-10" version="1">MPAVHGDLMTTVIPTSNELPPDIVPRQVTLRDRVTVATLVPFTSADAVPRSLLAYLSDQLNKEIEGGDTYAMIDPIPLEQFGSYWFSNFGAIMLLGDIKSVHELQALGRGRANWSKICLGSFNIRPNYPGRSSHVCNGMFLVTDAARNKGVGRLMGEGYLEWAPKMGYTYAVFNLVYESNVASCRLWDALGFKRIGRVPGGGRLISNPGQYVDAIIYGRDLGPEGEDSVTQDRFDKIRYYLKHSKYPRGADRAEKSRLRSAATHYKLISGKEGDGEKLMLKDKEVVSDPQQQYDIARQMHMQQHAGINKTTAAIAVKYHWVRIKETVSRVIRDCPQCKETLKPPIINGIMNEDTPDEDEDELGTQEVDLPEDDADLGPGDPMGGHTLMNHTAMDAHHNSNPFVTAHSVVQGPVDSIADYTGLPLDPQIIEIHQQLPRFHSHDPISEAYAHAAHSLHASNFDNDVRHHSAHDYHMMVDDPTDPDSASALHQEALGLVHSQAHDVHHEQILKYQYVGQPDDDLDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2Y5</accession>
    <name>A0A317X2Y5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_358106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469755.1">
        <property type="nucleotide sequence ID" value="XM_025607151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2Y5"/>
    <dbReference type="STRING" id="1450535.A0A317X2Y5"/>
    <dbReference type="GeneID" id="37109294"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06137">
        <property type="entry name" value="DEDDh_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF114">
        <property type="entry name" value="EXONUCLEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="5">
        <location>
            <begin position="36"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY92994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="282" mass="30988" checksum="21838E5FB8BDC9D4" modified="2018-10-10" version="1">MSAISKGKGNPRIGTILRTKFENTPTSPTNRHQKRKAVVIDCEMVTVSSGRRHIASIGAVDFLTGEVLLNHHVYPEMRIVNYNTRYSGINHASMMAAVNSGVALRGWEGARQALWEHVDKDTVLIGHALQNDLATIGVIHSRVVDSQILTGEAIFPTLPVVDSLPRLTGLKGLTSELVGYEIQTGRKGHTALEDAYATRDVIIWCLRNPGLLDDWAVREKKQYEEYKKQQKEKREQKKKKDAAKGSAAAVATDPVKPLQTNNSDECGRERGSDIAEGSGPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3G7</accession>
    <name>A0A317X3G7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arginine N-methyltransferase 2</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_532923</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469945.1">
        <property type="nucleotide sequence ID" value="XM_025611224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3G7"/>
    <dbReference type="STRING" id="1450535.A0A317X3G7"/>
    <dbReference type="GeneID" id="37113367"/>
    <dbReference type="OrthoDB" id="19014at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019702">
        <property type="term" value="F:protein arginine N5-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000135">
        <property type="entry name" value="Arginine N-methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017408">
        <property type="entry name" value="Arginine_N-MeTrfase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051038">
        <property type="entry name" value="RMT2/GAMT_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026480">
        <property type="entry name" value="RMT2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32379:SF1">
        <property type="entry name" value="GUANIDINOACETATE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038148">
        <property type="entry name" value="Arginine_N-mtfrase-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51559">
        <property type="entry name" value="SAM_RMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RMT2" evidence="10">
        <location>
            <begin position="193"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="151"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="415" mass="46760" checksum="AE94B0B4DAA27E56" modified="2018-10-10" version="1">MTTITPTSDMEINVDIYTQELLLAASNHSIPTLRRLIRENQLPGNPVNVKDPETGFSPLHTAIAAYEPEEQQANGVDPNASEAEQSGSSAAETVKFLLQEGAIWNDLDLNNETPGCIAKRIGAGELYEMMVDAGVRAELLLGRLDGYEALSDDEDDEEEQEQEGEQAETENEQQEESTTTEPTEPTTEEEPSTDPSVTNPRYLDSTLTFTNDRLLDADQNGVMMSWESTIMEKSAQKLLPTPGLRVLNIGHGMGIVDTFIQSHQPSEHHIIEAHPSVVAEMKRKGWDQKPGVRIHEGRWQEVLPALVGEGVEVDAIYYDTFAESYADFREFFSEQVIGILEQDGGRWGFFNGMGADRQISYDVYQKVVEIDLFEAGFEVEWEEIEVPKLEGEWEGVRRPYWMIEKYRLPVCKFMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4R1</accession>
    <name>A0A317X4R1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_461594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469666.1">
        <property type="nucleotide sequence ID" value="XM_025607938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4R1"/>
    <dbReference type="STRING" id="1450535.A0A317X4R1"/>
    <dbReference type="GeneID" id="37110081"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="532" mass="60033" checksum="EE755084DE0BB81A" modified="2018-10-10" version="1">MSNPPVAIPLISLILGISTHLGYFIHADIEKHAVLVANCFFFWPVLGLISLAVLGYRDAARSGWMVFVSYESGLFLSIAVYRYFFHAVGGFPGPRMARISALWAVWPAVVQARWYVKVRELHAVYGDVVRIKPREISINDPTAIRDIYGVGTTCVKGPFYDLQYPHRSLQMVRDKGYHSRRRRVWDRGFSSRGLCSFVHCRDLVRLIESKGSQRQEVTELIDGVTFDSMGILAFSKSFNVLHGSLSKMMRRMKSMGRGGAGLVWAPWTIILLRNMVGVRRVTVQWLEWCAQEVEDRKRRSAELDRRDLFSYLIEDTTGTDGDLVRDTELAIGAGSDTTASTLNTLLYLLARHPDKLQRLREEIDSAVSADEELSHGALIGKPYLEGCINESLRLYPAVLSGLQRETGPEGLTTAGVYIPPYTLVSVPTYTIQRDPRNFGEPDEFIPERWSSHPELVIRKEAMIPFSTGTYSCVGRPFAMMEMRLLVSTIVRHFEIEFPPGEGKESLGSLGGTGPQDCFTTHMPRYHLIFTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5B5</accession>
    <name>A0A317X5B5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_511733</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470565.1">
        <property type="nucleotide sequence ID" value="XM_025609780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5B5"/>
    <dbReference type="STRING" id="1450535.A0A317X5B5"/>
    <dbReference type="GeneID" id="37111923"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="127" mass="14483" checksum="81293CB2F5F926A0" modified="2018-10-10" version="1">MVEHEPEPKRFSPKVPVQLDPPKYDPITVEELSKCDGTDPNRPTLVAIKGIVFDVTRNSAYSPSGQYHVFAGKDPSRALASSSLKPEDCRPDWYDLEDKEKTVLDEWFTFFSKRYNIVGKVQDATNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5S6</accession>
    <name>A0A317X5S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_315618</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470727.1">
        <property type="nucleotide sequence ID" value="XM_025606856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5S6"/>
    <dbReference type="STRING" id="1450535.A0A317X5S6"/>
    <dbReference type="GeneID" id="37108999"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="472" mass="51708" checksum="D687C52A387E26B9" modified="2018-10-10" version="1">MAIDFTTFYNVIDNELTSTAQTRHGINPATGQPNPQVPLTPDEDIDRAVAAAGRAFRTWSRTSFYERRAAIHAFADLIETHTEPFAALLTQEQGKPLSQATTEVSMALQWARGLSNLTLPETILEETEDLQVIQRYTPIGVCAAIVPWNYPLLLAVGKIVQAVYTGNTVIVKPSPYTPYCDLKLAELATQCFPPGVVQALSGDDELGPVLTGHPDIQKISFTGSAATGQLVMATCARTLKKLTLELGGNDPAIICEDVDIDAVVPKVAVLCFLCCSQICMMIKRLYVHEKIYDEFRDKLVQFVQALKMGEGTEPDVFFGPVQNSMQFNKANNFLRDIKNSGLTAISSHVPNPSGFFIPPTIVDNPPDSSPVVWQEQFAPILPILKWSDEADVLARANDSVYGLAASVWSRDLQRARRMADQLEAGSVFVNTHFECAPYAPFGGYKQSGMGTELGVNGLIGYCNSQTLWLRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5T5</accession>
    <name>A0A317X5T5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_555077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469638.1">
        <property type="nucleotide sequence ID" value="XM_025613768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5T5"/>
    <dbReference type="STRING" id="1450535.A0A317X5T5"/>
    <dbReference type="GeneID" id="37115911"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF42">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="172" mass="19392" checksum="37E752A9342ECE08" modified="2018-10-10" version="1">MARPRTDHLLEKYGKPAFTPSLPDSIFREQSTLELKGQMRRDFSTCTPLRGVEELLSKLVRGNRKPARDIYLVALEALNSALGSEEKAILPEECLVFEDSVIGVEARRRAGMRVVWVPHPDVAVEYRARQKDVLAGRTGMIEIGDDWQLERLMMGGGKYGGFGTLQLPNIWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X695</accession>
    <name>A0A317X695_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-L-rhamnosidase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_615870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469838.1">
        <property type="nucleotide sequence ID" value="XM_025616776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X695"/>
    <dbReference type="STRING" id="1450535.A0A317X695"/>
    <dbReference type="GeneID" id="37118919"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF1">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28455" checksum="C22E213EA8E8E998" modified="2018-10-10" version="1">MSLSKADKTVMTPGWVATTQAFLRWVFTPLGFFITIYGLNVIAWGGMLFLLLCNAAPAMCHPSCNSPNSSRRIWIEIDSQILNALFCVTGFGLAPWRIRDLCQWCRWRLARSPRTRQRGLAHLAEIHAKWFLPEAQDGVLPSTTDAASGLRLPTPLWKMDAVVWGNMLNSIFQVCLAVCMWAMNRFNRPSWTTGLFVCLACLVAAGAGIIMWLEKKRINKASEHPGALLLVPHANPSARSDTLGQGYLHVNQADSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6D2</accession>
    <name>A0A317X6D2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_510278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470880.1">
        <property type="nucleotide sequence ID" value="XM_025609728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6D2"/>
    <dbReference type="GeneID" id="37111871"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="336" mass="38580" checksum="AD03C9AF92280A0B" modified="2018-10-10" version="1">MPAFVSLSSFILAASLSTLTYLALLHRCLKNRINHEKSYGSLPSSESIIITTIPPEIYTSEYYALHDRASRRVPRQLLPHQKDTNILTIFLRRNMMAFANFPQAYMLWAVSPAATRPTFHASHISSLDFNKGDLTCGIYRVLERTADKVEFGMTHKGVEGRLVFRLWDEDKDVVFTSETAMWTRMDEMQRATMPLENPVLRFFHELAAWWLLDSGVKYLVDWDGDTDSERFAGGFLDKAWISHCCRFGADMDKKSRQLSFPLFLKRYYIWYLNQLQGRLWGFVCLPRITLLLIHEVPVYSDPIYTENRNPTCASTFTTTSLAAAMSDASALILASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6D4</accession>
    <name>A0A317X6D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_621583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470904.1">
        <property type="nucleotide sequence ID" value="XM_025617009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6D4"/>
    <dbReference type="STRING" id="1450535.A0A317X6D4"/>
    <dbReference type="GeneID" id="37119152"/>
    <dbReference type="OrthoDB" id="2262349at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000012">
        <property type="entry name" value="C6 transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="45"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="865"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="967"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="150"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116612" checksum="1F00986622985466" modified="2018-10-10" version="1">MAAPANNGQQEGPPVYAHQSRAPKSPSPSPSHQGQQPQHRRGYQACDPCRKRKVKCDLGSVDNPRPPPCVRCRRESKRCEFSATRRKRKPSEVEEPTEATLRRDKRMMVGEVISNNGSVSDGGSSYAPPERTSSFDNSASLPRPKWADESPAATTQLPSSSTTTSQRFTSTQTSSTTTQFPEPRSTRLPLYTAAERSHGPSFSLEGGQPMMNRTAVELLSPAISNSHDALHLLSEAAGRTEDLNRQSLENRYAARQSVSSFNSPMSPLTQAGTPRSGGGSFSRPPRSGTVPVGNYYQGGGSGSADSQLPDGRGQADPSETAQDPGFVDAVKAWSRLRFVRAGWLSVEEAMAYVAYYYEHLAPLSPIVIPDFSSPSTHRTLLTDEPVLAVTILTTASRHRKPKGDGAYTRAFYIHDRLWSYLRGMIERLFWGQEKFGGNGVGISKPRSFDLAPMSSKVSHKGNLRSLGTIEALLILTDWHPRNLHFPPGDDENALLDLDAQTQSRYERELETDAESTANRVPNSAAEGRLAFQKWLEPAWRSDRMSWMLLSTAQALAFELGVFDQKNDAKAASEPPSEQTRKRRLRRLILVYITQSSGRLGIPSMLPLPQWTSDIQPTSVTGAKGSDTIVDRMHDCWIGISKIMYQSNQLLFASSEQTSELIRSGRYRDQIDRFQPFLREWRHNIDTIDLAPPMRCLLMIEYEYTRLYVNSLALQAVVDRWTTMSNEAAQAQSTRPNSGPSSGTGWFHVLMELYRVNEQYIQEVVDASRKILQTVLEILVPRDHLKHAPVRTCFRILSGMIFILKTFTLGAKEDDVRVSLDLQDRTIEALKTCVVDDVHLNHAIARLLELLTTSIRTRFLRFAPLDRSGDGEQERPSAPASRHQSPRPREGAPNRREGSSHAWTPAQSATQNLGYVDSNSQAGAGMGSVHDPLAGIPAQPINSSNINVSFMPPPPSVYYNYYDPSATPPTGELEGTSVPSQSMHDNPGASGGLPDWFALPLDQFFNSSTAVVDQGLGGTGPMVGEFDMLEVLLNEQYDGHGEGGESAGGGNLPSQFLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6T2</accession>
    <name>A0A317X6T2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_563775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471097.1">
        <property type="nucleotide sequence ID" value="XM_025614376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6T2"/>
    <dbReference type="STRING" id="1450535.A0A317X6T2"/>
    <dbReference type="GeneID" id="37116519"/>
    <dbReference type="OrthoDB" id="5291055at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43701" checksum="E4261FF95601E5A8" modified="2018-10-10" version="1">MSHNPPPPPPAPPAPPPPQRQVSPKPIASPDAPKYPPGSFGIGVEVEFLLEPRGRSSASPSIRDFSQKVASTYNAYLAETGSTRHPQMHNAIDEAYLGPQFAEWSLDSDSTIETPNKGQAPWGLECISPIFRAHAGSQWRQHIEFLWRFFSLHYDISSNDSCGTHVHISRVGGYSLTNLKKICQSIIHFEPAFEALLPESRLSNEYSRSNWLDNANFGHRNLTRNQSIVVIEQATNMRELVLLMNPDHDKMFGWNFLYLLNSPHGTIEFRRGPASTSAQNVFVYIEVAMSFIEAAIQLGGPESLCKVPATVGGLRWFLQTANLPDQMPGLYDSRYLEVFFASKADSVFREPMPLGTLSAHKLNKLARKKEEDKRKNIAMIKMLHEPYWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6V5</accession>
    <name>A0A317X6V5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470826.1">
        <property type="nucleotide sequence ID" value="XM_025611031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6V5"/>
    <dbReference type="STRING" id="1450535.A0A317X6V5"/>
    <dbReference type="GeneID" id="37113174"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="301" mass="34092" checksum="CB411458745C4256" modified="2018-10-10" version="1">MPRPLVGIGHSYGGNIITNLAYIHPRLFTTVLLLDPVIQTSLPPMGFGTDPTGTINFSLWRQDVWPNRAAAAQAHRTLTKSWDPRCAERMIKYAFRDLPTPLHPGVHAANDTTTNQVDSPVTLTTTKYHDVIAQIRQNFSSRIVEGRMEIDRTTHADLDTEVVSTPMYRPEAPSTYYRLPTLRPSCLWVLGAKTYLRLDEMREGIRTCGCGVGGSGGVAQARVKEVIMSGLGHLFPFQDVGRSAETCAAWLETEMERYRVAEKEWKEKRQLMSKRDHLVLTDEWFKVLRPPRQSQSKKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7U1</accession>
    <name>A0A317X7U1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_511355</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470388.1">
        <property type="nucleotide sequence ID" value="XM_025609764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7U1"/>
    <dbReference type="STRING" id="1450535.A0A317X7U1"/>
    <dbReference type="GeneID" id="37111907"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="525"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="649"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="346"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="743" mass="81104" checksum="3AE07C31A3E6DBCA" modified="2018-10-10" version="1">MSSPRMSDNGEGSSSQRHRSSSPISTSAMRSGSPAPDASSFRQASIARLASPIPSPSTSYSSRQLPLPIQSTAGTNQDLRRVDNPSSLPGPGQSMIASALQDHLGRSPPPRVGTPPRRTASPALLNQPVRSIYGSFDNKAGREGSIYSTGPFEDPEVIKRHLVQPQIENRDIHSSGGVTNNTEDEFSSLQLQGGDITRQVYRWAEDAEAGSSLRKPNRSRSFSHARPAPEDDTMNINSIRVPGGFRRDYLRRAVGPGDLDGTGSQTAAAQQFPTSSFLEFLTLYGHFAGEELEEDDEVLGPDEYFSSDTYDEAEGREPGEDSALLRPDTAGRRKRKPRGGTGTNTRTGAALLLLKSFVGTGVLFLPRAFLNGGMLFSSLVLLAVSLLSFYCFILLVNTRLKIDGSFGDIGGALYGKHMRRIILGSIVLSQLGFVSAYIVFTAENLQAFVLAVSKCKSFIDIKFMVLLQLVIFLPLSLVRDISKLGFTALVADLFILLGLIYLFYYDFLTISNQGGIADIISFNPSTWTLFIGTAIFTYEGIGLIIPIQESMKHPQKFPGVLAMVMVIITIVFLGAGAFSYAAYGSATKTVVILNMPQDDKFVNAVQFLYSLAILLSTPLQLFPAIRIMENELFTRSGKYNPSIKWKKNCFRFFLVMICAFIAWGGAEDLDKFVSLVGSFACVPLIYVYPPLLHLKACAQSRRQQIADIALSIFGVLSCLYTTALTLNNWVNGEDVKAPGYCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7Y4</accession>
    <name>A0A317X7Y4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Blue light-inducible protein Bli-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_484960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471485.1">
        <property type="nucleotide sequence ID" value="XM_025608972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7Y4"/>
    <dbReference type="STRING" id="1450535.A0A317X7Y4"/>
    <dbReference type="GeneID" id="37111115"/>
    <dbReference type="OrthoDB" id="434253at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052917">
        <property type="entry name" value="Stress-Dev_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038725">
        <property type="entry name" value="YdaG_split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34818:SF1">
        <property type="entry name" value="PROTEIN BLI-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16242">
        <property type="entry name" value="Pyrid_ox_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="General stress protein FMN-binding split barrel" evidence="2">
        <location>
            <begin position="31"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="208" mass="22409" checksum="7CE78DD91BE648A7" modified="2018-10-10" version="1">MSNIQTPTTGTQPLDPYKAKSVEDPPLEQKISDLSTFINEQKFGMLTTKSSEDDLLTSRCMALAGQENASTTLIFHTNLFSHKTMDLTVHPTETNMSFLDPISGSWASISGTATIVADKETVGKYYSPALSAWLGDLGDGVHDGGPGDPRIGVIKLEAKTAVYAVSRKGILGRAVETVKSVASGDVPAINSIRELSRAELDEWRRTHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X822</accession>
    <name>A0A317X822_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative small nuclear ribonucleo protein complex protein Nhp2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_531697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471525.1">
        <property type="nucleotide sequence ID" value="XM_025610955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X822"/>
    <dbReference type="STRING" id="1450535.A0A317X822"/>
    <dbReference type="GeneID" id="37113098"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000027">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="100"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="234" mass="25196" checksum="09ACD9D797442F59" modified="2018-10-10" version="1">MAKDRTEKKDKREKKDKRAEKDGVSKSSKKDKKEKKDKVALADAVEKELTTKVLEGIDQAVSAETPANGVETELMEIDARPVGAIVPFASPLVEDKAAKKALKSVKKAAVNKCLKRGVKEVVKALRKSPIPAANASIGIPNGVVILAADISPMDVISHIPVLCEDHGIPYVFVTSRAELGNSAATKRPTSVVMVVPKSASKGKKKDSEDDGEDFTEVFEELAKLAQKEAKKVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X850</accession>
    <name>A0A317X850_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_461141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469839.1">
        <property type="nucleotide sequence ID" value="XM_025607914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X850"/>
    <dbReference type="STRING" id="1450535.A0A317X850"/>
    <dbReference type="GeneID" id="37110057"/>
    <dbReference type="OrthoDB" id="3436860at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18306" checksum="7F3D99C9D9100D65" modified="2018-10-10" version="1">MIDFTKFLDTADRPLFKRRLHILIASLICLTFLLIIVRLAIPRTPATRTNIWGIAVCIKAAVFLTYQVLTTYKDRFKRWASPKANMILDIIDTVFWFALFIISILGGSGGHSAGSKALGAIVAILALVLCGVVGFLSFICVQDYRYFKVHGVVPGKEKSAGEGEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X862</accession>
    <name>A0A317X862_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermidine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_509507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471544.1">
        <property type="nucleotide sequence ID" value="XM_025609705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X862"/>
    <dbReference type="STRING" id="1450535.A0A317X862"/>
    <dbReference type="GeneID" id="37111848"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="292" mass="33414" checksum="84AA237860AAE923" modified="2018-10-10" version="1">MSDITHPTIKDGWFSEQSGMWPGQAMNLKVNQILHHEKSKYQDVLVFESSDYGTVLVLDNVIQCTERDEFSYQEMITHLAMNSHPNPKKVLVIGGGDGGVLREVVKHETVEEAILCDIDEAVIRVSKKYLPGMSIGFQHPNVKVHVGDGFKFLEERKNEFDVIITDSSDPEGPAESLFQKPYFELLRDALRDGGVITTQAENQWLHLKLITDLKKSCKEVFPVAEYAYTTIPTYPSGQIGFMVCCKDKDRNVKEPIRKWSREEEERLCRYYNQDIHRASFILPNFARKALDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X880</accession>
    <name>A0A317X880_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 pisatin demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_610418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471575.1">
        <property type="nucleotide sequence ID" value="XM_025616608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X880"/>
    <dbReference type="STRING" id="1450535.A0A317X880"/>
    <dbReference type="GeneID" id="37118751"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="490" mass="54824" checksum="1D3657E6ED647F07" modified="2018-10-10" version="1">MASLIPILAQLAVASLVIRVAYLCYFHPLARYPGPFWARFTNLWRFFTFLGGHHHLSEQQLHEKYGRVVRVAPDWLSFSSLEDFDAIYGFNKSIEKGDFFTFGRGSSQCEASIFSTKSNSLHRQKKRKVFGPALSSAKVGKYESVITKHVAVLLARLESSRRPANDRIAAVNVAPLMSQFTLDTMLEVLFGPAVASHPYTDSAVAGDICSQLRKMTKMAWSFSLWPFYGWVMNSRPVSAFLRRPFYQKKGVPTGMAGLMAAGHISITRNPESIARAPQPGIVKSWLEVPVDDANRMTQGEVLAEAMNMVFAGPGSMAAALTAILRKEAVFFGGNTMAASIPLELQAVIKETMRLRAVFPTAFPRVIKPGAERVIPSLSSPLPVGTTVSANTYVLGRSRELWGDDVDEWTPQRWLGDDEHRRQMETKFIAFSRGPRGCIGRDLAMLVIAKAVMALLQQWQIRSVGQLEGRSWLEMQYDDCWLELERRIPAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X951</accession>
    <name>A0A317X951_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_458176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470888.1">
        <property type="nucleotide sequence ID" value="XM_025607777.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X951"/>
    <dbReference type="GeneID" id="37109920"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="262"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="618"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="745"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="889"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="968"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="999"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1383" mass="154073" checksum="8DCAF3380EA3C084" modified="2018-10-10" version="1">MSRPASATENTWSGPLVTPAASAQHDCSERPELLHDKQQRHHDPRGQLIQDDVQQAPSPSRAESPTAHQWAKPASTFSLKRATTVPVERLSRPDRSHTPQLSERDSIFATHYLPSDTELVVTPQIPPVDDIDNGPPTSLIPPLEDVPSSPSPISPHKVLLPRHTHVDPSHMEVDVRRKHQLGSPSLLPSAGPHSSPLLPVDSDATLGKRSELSSRSAHIPVWESLQHLRKLTPNDAATKPAVAEDPSAHRSLLSASLSDASLPPYQHVTRSPSKKSPVTSVEAIPHPWSGQQFQDGTRVAKPERSSSRGRRGRVEQSIEANLTNSEPTSHVRSRKSSHYLGLFKENTTSPDRKRREERVGRHDELSEPNEKQQLAAHSEPRYSGENRDSQLQIPSFSDETGLTGSKSLSQLSIADATLFSPRLESETRPQMSTDSVTKSKPKALPRNLLDEIRNFHLTPGGARGTSFSRSIPTQFAERGRDYFSKEPAHHDHLEPHLTPTDVGRDQRRGSGQLEDEEDEQISSAVYFPHERVTLSEEVDQVQTFTDGQDGVEPGDMSTAQSSHVLVPKRHVVSEEQEANHVDISLRSKNDSRILHGDLQGRQDAPIEELSEESLALIPERTAESSTCGSEFASADESGMSVRDEESSVTDEAEVTPTATPTQRPRVTRPRREHESTTPLGAVELKPYRHQVGGHTTVFRFSRRAVCKQLNNRENEFYERIERRHPEMLMFLPRYIGVLNVTFSKTPKRSKTPAKNAERPDSGSATHTSNGFDHDGAISADSRAPARNETEPQRIFSQKQVTGVIPQVILENNRHIIPADLFSHCQRPRTADGSLSANRRFPVEFGQLTKEGKTEGCLLEEPQTLKRKQWGATTVNRKLQEQVLREVFSPPAVHHHRRHARGHLNLPRTSSDGVEIRRRANLSEDQTSSSRRIAPDQAQPTQSGAIDITRQTKDGPGLSSSASTALEASHNRLEKVRTEESPPRSSSMSRTRQVRRRRSGSGLQRRGSISSGQPGGDLLFFEDDGYGGDKEDGIFSMEGDNPIALTSQPATNASVPTSPNGVDSDTLHLDGRAGNDIPSRHFFSPATKDVDDTQLPSNPKEAQTRQDDRVQFFLLLEDLTAGMNKPCVLDLKMGTRQYGIEADEKKRKSQRRKCQSTTSQQLGVRLCGMQSWNVKKQEYSFEDKYFGRDLKSGREFQDALTRFLYDGASYRSVAKKIPSILEKLAKLENMIRRLKRYRLYASSLLILYDGEPTTPDKASQNNGQSGSASIRDTLQRQASDDGYTDVQLKIVDFANCVTGEDELSPDAPCPPQHPDDIDRGYLRGLRSLRMYFQRILKEITQDDYVERGEGEAIALGSQHAGRHDSSQRYWDENVLETDPGEVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9I6</accession>
    <name>A0A317X9I6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_485204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471612.1">
        <property type="nucleotide sequence ID" value="XM_025608977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9I6"/>
    <dbReference type="STRING" id="1450535.A0A317X9I6"/>
    <dbReference type="GeneID" id="37111120"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31548" checksum="D860D16011E18866" modified="2018-10-10" version="1">MRLFVIPISTRQALIYARPLRHGASQAPSIHEKITQKAAETWAKWEEADKGWKKHLVSWGNRVQQRIPYQEWGLKSIPSLESARRIDESHGTKKVDVLFPGNAIRPEKLQTMLQAIATERQDLHRRRMWLSLLVTPLTIPIGLIPLVPNVPFFYLVYRAWSHGRALNGSKHLEFLLEKDLLNPTSHPGLEELYAKRVSYALESKGVGKPIVEMVEEVEKSDDRLLLRMKDAKKLATILEAPDLALEAERAIIQVEEELKKETKNDGEDVTSDKKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAR1</accession>
    <name>A0A317XAR1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_347372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470371.1">
        <property type="nucleotide sequence ID" value="XM_025607084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAR1"/>
    <dbReference type="GeneID" id="37109227"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="98" mass="11477" checksum="FA92037E2DBE67DF" modified="2018-10-10" version="1">MRGSGASKPKARPDRGIGLWCHQPVFLSLTWHLLNWSSLLCLETVRFPCHIHIYQVSTWQNRFIALQEVLLGMKVLFTCFFQYIAQASSFRLWTQYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAS8</accession>
    <name>A0A317XAS8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_563298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471503.1">
        <property type="nucleotide sequence ID" value="XM_025614352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAS8"/>
    <dbReference type="STRING" id="1450535.A0A317XAS8"/>
    <dbReference type="GeneID" id="37116495"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="509" mass="55071" checksum="272168721959D6EB" modified="2018-10-10" version="1">MDCNEKKIQPAAIDATLEVDRSRSHDEGETYELKKGFSSLTILSMTVILMATWEALSSTMAAGLVSGGPVSLVYGFLLAMIGALATAASLSELASMYPTAGGQYHFTAKLAPEKFQNPLSWAIGWTGTFGWISFAASAPFLAATMIQGLVVLNHETYEMERWQSTLVYWALVGLSTVINIWGSRLLSFVEGVSLLIHICAFIANIAVIWACSPTKHSADFVFTSFVNNSGWSSDGVAWSIGLLSSCYVLAGCDGAIHLGEEMNNPAVSVPYCMLGSVTINGVMGFAFLLAVLFCMGDMDAALNSSTGYPIIEVFRSATGSRAASTAMTSTIILTAWLGTIALLASAARMVWSLARDKALPGYRYLTELDTKAQAPTRSILATSTVLVLLGVVNIGSTTAFNAIISLAVLGLHVSYLVPITLILWCRLSRRHVALNYGPWRMGRFGVPINLVSVLYLGYTSIFMVFPPYQPVTAENMNYASLIFGAVLIFSAFYWFWRGRKEYTVSTIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAV3</accession>
    <name>A0A317XAV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_542564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472072.1">
        <property type="nucleotide sequence ID" value="XM_025613096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAV3"/>
    <dbReference type="GeneID" id="37115239"/>
    <dbReference type="OrthoDB" id="4507478at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="475" mass="53025" checksum="C73543B820718044" modified="2018-10-10" version="1">MGQLTIHWFTCNHLYPQWNAFVPFGGRPDQDIAPAAAIHASICPECLTPLTNCNKLFKEKLMSVKMLEIILDIPVTDGEFIHSMVHFYARGDHLRWEQPITPGARFLPGDPYLDSLEEESYMNTCDEESDFGLNVRWINYLPKSTYFYFSLMPLIIHDIPYATIQQAEAEHQTPATAQRVQTPPVAHPFVQMDPSVAQSDPFVSNPASASRGSNAQMVPGPNGPMYWLRKIPKINTGPRILRRKSCPDRTPPSSSGDETWSMVSDSPDGRWVPCIEASSRTNPSETAMDNDSENSPINSAADTSVPATENEYQESASFTDDDQLSQSADVIASVTSSDSPLVAPNMEPDVLEYQSSPVESNPWLLSSEMMREHSLQVRSPDESSSVLYPVNENTPLDDFMLSDPCPDLPAEEPQSLQDLLATELEIDPNGYDLECECQQDISFGCDFILYDSETDSTQAIELDDLDNRSYYPDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB45</accession>
    <name>A0A317XB45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_138172</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472605.1">
        <property type="nucleotide sequence ID" value="XM_025605706.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XB45"/>
    <dbReference type="GeneID" id="37107849"/>
    <dbReference type="OrthoDB" id="447173at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000007">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000004">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000075">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000829">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="1933"/>
            <end position="2071"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="2225"/>
            <end position="2546"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="2589"/>
            <end position="2739"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="2931"/>
            <end position="3097"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1633"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="3419"/>
            <end position="3460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY95844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="4344" mass="492567" checksum="458332B4C577495A" modified="2018-10-10" version="1">[encoded data, 4344 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBX6</accession>
    <name>A0A317XBX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_317921</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470811.1">
        <property type="nucleotide sequence ID" value="XM_025606883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBX6"/>
    <dbReference type="GeneID" id="37109026"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF26">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="556"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="697"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="33"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="206"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="418"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="797"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY94050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="897" mass="99722" checksum="8236FE7CE7A50AB0" modified="2018-10-10" version="1">MAIHDVGLQGLHHLAGRTSSEDVQGTSNSASGLVSTLVPSLIVAVAMVVGFIILRRREFRMYMPRTYLGVLRPSERTPASPTGLWDWILQMYRLPDEYVLQHHSMDAYLLLRFLKIVSMICFVGALMTWPILWPINATGGGGKKQMDKLSMSNITSDKYARYFAHAFVAWLFVGFVFFTITRECIFYINLRHAYALSPAYASRLSSRTVLFTAVTEDYLNRDKIRQMFGPEKVKTVWLTTNTSELDDKVAARDDAAMKLEAAETKLIKLANAARLKALKKQGNTEDGQTADDTLCNDSDDESGSVAARWVRPSDRPTHRLTILVGKKVDTINWARSEIERLSPEIEELQARHRAGDADLVSSVFVEFHHQVDAQLAYQSVAHNSPLRMAPRYIGLEPTQVIWSNLRIKWWERLIRYSATIAFVIALIVFWAIPTAVVGTISNINYIVDKVPFLGFIEDVPSWILGVITSLLPTVLMSVLMALLPIILRLAAKLGGAPTAAAVELTTQNFYFAFEVIQVFLVVTLASSASSVVTKIINKPTSAASLLAQNIPTASNFYISYIILQGLSFSAGALLQISGLILGKILGKLLDSTPRKMYTRWSSLSGLGWGTVYPVFTLLAVIAIVYSCIAPLVLGFAAIGLYLFYFAYRYNMLYVTNADIDTQGRAYVQALKHLTVGCYLLMVCLIGLFAIATAANTIALGPLILLIILLIVCILYHVALNSALEPLINYLPKNLEAEEEALLSREETKLSHSGEASDEGLAGGSGARDSGVANVDSAEKGLTVTDTPTEKPNFLLRYLRPDKYDGYVQMRRLVPSAQETATYSAEVERDAYFPPSIKAQPPLLWIPRDELGVSRQEIKHTSRVIEITDEDAWLDEKNNIRWDQDKGVPPIFSEKIYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC49</accession>
    <name>A0A317XC49_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_570492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472874.1">
        <property type="nucleotide sequence ID" value="XM_025614817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC49"/>
    <dbReference type="STRING" id="1450535.A0A317XC49"/>
    <dbReference type="GeneID" id="37116960"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY96113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="519" mass="55217" checksum="0F161A7B1A17AFC3" modified="2018-10-10" version="1">MTANDDDEAPLLRDPPLPVYGGLEGPPPTAHQPSFKRNLGTAEAFSIIISIVIGSGIFTSPGAIDSNVPSPGAALIVWLAGGILAWTGAATMAELGTAIPGEGGVQPYLQYIFGDVFGFLAAWTWVIAIVPASLAIASIVFVESIYSAVGVTDRSGKLTHKALAMLVIIVIGMANSVSTQFTTCLNRFFVMTKFAAILAIVTAAFGVVLSHLVGWNQTPQPESHDWLTRSWFGPRNTVTLDGSEIDWSKLSGWETLGHCSAALYSALWAYSGWDKVIYVSAELSAPARQLPLTINTAIPIVILSFIAVNVAYYILLPWGVVSTTDSVAVIQTSFSHLLGPVFGIAAAALICLVVAGSLLGCSFVASRMVVAAAKSDWLPGFLGRIGSVSGQSTSTADAPVNAIIFNTVCTVLYILFGNFRALVTFNGLAEYTFFFLAMVGAIILRIREPQLHRPYKPFIFAPILFNLVSGLVVTRGAIFAPMQAVVLIGVWAVGLGFYGGRRKWLRRGGKASSRASTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC52</accession>
    <name>A0A317XC52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_561740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472937.1">
        <property type="nucleotide sequence ID" value="XM_025614239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC52"/>
    <dbReference type="STRING" id="1450535.A0A317XC52"/>
    <dbReference type="GeneID" id="37116382"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="174"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY96176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="330" mass="37024" checksum="974307A6DC39A6B9" modified="2018-10-10" version="1">MATAPPIIDFGPFYGDDAGKKAELVQQVRQACERHGFFQIINHRVPSDLQAAILQQAQELFRLPLEVKDKYSRAVEPVNLGYERLREQSFGNGTGDLKEGFYLCQDLPMGHPLIGRFSLGLNKYPEEMQNLAIFRNTVNNYHIAMADLALNIFKVLAQTLDLNEDWFDGFCHDSANIMRLLRYPPQPADGLERGIGAHTDFGGLTILLQDDKGGLQVWDRESSQWADAEPVPGALVVNLGNMMMRWTNDQFLSNLHRVINTSGQERYSVPFFISGNLDYLVECIPSCKAETEEAKYPPIRVEDWLEARYSETYGGAGAGELSKDVVSASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC66</accession>
    <name>A0A317XC66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_458591</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470891.1">
        <property type="nucleotide sequence ID" value="XM_025607805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC66"/>
    <dbReference type="STRING" id="1450535.A0A317XC66"/>
    <dbReference type="GeneID" id="37109948"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14653">
        <property type="entry name" value="ZIP_Gal4p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="705" mass="79031" checksum="525426AD3EC80D61" modified="2018-10-10" version="1">MENQPASPAAQQGQRPRKVRTRISTACTRCQKRKIRCDALLPACSACKRAGVPCIGGGASRDYVADLEARIKWLEAIVQEHVPSIDLTAGPGHSPNLDGGVPYGDWNQLQRTQQSREPRDVESPSEINDQIGLVSITTGTDLRYLGPSSGLFFTKFVLAGLGRRLHVDNNSTPGVKADSLAVPPDLLVPQPKELPSDHRHARWLSQAYFDIVHLQFPILHEPWYWETVKKVYADTEVTAVDEFQVLMVIAIGASLLSRRTKVMLSAEGYFASAMKLVDKVMKTSSVGVAQCILLLQMYALNNPTSGLSLWTLHHHGLALAIELGLHRNMPASKFTLLEREVRRRIFWCTYTIDRLLSTLMGRPMGVVDEQCELNVINHHEPLTKMTSAVHLFKLARFNSEIKCVLYCVDRQYPPYTQPAITDAESWKVDILIRLRQWREAIPRHSEASTPYYLNLLSEIKYHELVMLVLRPNPRFQNPDKASLRECLSSAITCSELYHQLYIANSLHYGWISVHSLFLCLMVMFYCVWTPHGIAEEADLDSLMRALKSSSDVLSAMGEYWPEAKRSRDVLDRVLMATIRRFTHHHRSSIIRSSPISSGSQGSMTTMRSLLPSDHPAEGSSYMDLPSNSAPPLQNDDAGVGDDDDDLFGLNYGDPETSFTSADVLSHFLGSGTDVIMGDSYDFEQLGDRDGLGWFGESLRDFGHPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCF0</accession>
    <name>A0A317XCF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_226146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472133.1">
        <property type="nucleotide sequence ID" value="XM_025606260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCF0"/>
    <dbReference type="GeneID" id="37108403"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8231" checksum="D4ECBC32D3EA9A71" modified="2018-10-10" version="1">MTYLPTVLLFSPLRLGSVRDGREEGGVDKVVSGSFSWGWFGFFFWSLWISLVRGIYLWLVCYGGGDRIGKGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCI9</accession>
    <name>A0A317XCI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_601224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472806.1">
        <property type="nucleotide sequence ID" value="XM_025616377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCI9"/>
    <dbReference type="STRING" id="1450535.A0A317XCI9"/>
    <dbReference type="GeneID" id="37118520"/>
    <dbReference type="OrthoDB" id="5398233at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF152">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="382" mass="42618" checksum="3ED8803A7622E571" modified="2018-10-10" version="1">MGYNLTAEMFSEWAIGLVVVAVRLYARFSVDRGIFRWDDLCLVLGTIFWTLLVVFLYLCTAVYGSNIGLNDTTAAEVSDDYVPALRQGSIYAFLAWLAYILMVWSFKGVLVVLYNRLTVGLKQNRLALAVGVLSLCTFITSLLFDLLNCRPIQKNWQIKPYAGNNCTVRPLNYIVIEVLSILTDLCIMCVPIPLIIIAKIPTSQKWILSGLFSSGIFVMVAAALRAYYSVKELKTLSTALGWASRQAFVSAIIVCAPGIKPLLSRFSWFASYSSSRGYDKKDRTRTTTFFNSKSGGRDVTVVSTCEPQPYELSSLGWKRNRHMSSGESQEHIMDFPLPTQQGNGPDLERNTGIMITTHVTLAHEDVAPDDLHTVPTTPPFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCJ8</accession>
    <name>A0A317XCJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_542133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472816.1">
        <property type="nucleotide sequence ID" value="XM_025613080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCJ8"/>
    <dbReference type="GeneID" id="37115223"/>
    <dbReference type="OrthoDB" id="10401684at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="667" mass="73846" checksum="57B54C0CF1E0937A" modified="2018-10-10" version="1">MLKGIITAYLSLVYNIGCGPAMGLTLWPISVWFTFVLWTRSRWLLKENIEIGLEVVRLSAAKGHASYSVKVAEIAVDSLRGLIAKKGSNEAEADETVKALSDDLVRAINRLHKKNQTNILTEVIDTHIAKFDRALHEGSKKAKNLASAAMVILSSCVKQHDDSEYALNYLAERFVRCLQASKMRQDRLVTGIVNEEVMKLNHLAGKGAEKQAKFLLLAILALLRTSHRPYLVEPLRAISSATVDALSRMTDDGHHSILDNLLKDSADTIYTALRTKEFEAKHISGAIQSLMIAAFGRNADGLIEKLSVSWVDVWNRVAEIGHDVETKNKFQLLIAEREDAIYLGVENESHKSASSWDVSFELLLTAMKRGKEDVRDGLSHSIISGLARAKKERGDGSVRSLICGNALAFSQACRQGDIRRAKAVSNTCIQLIRTAMSEREDWLVKDLSAVWVAELDMISINGTGVSLDGMLYDVLTKPFTDMIRGGDKSKAQKQSNVGIELLLAAIRGRKPSSISSLSKSWVVSLINAKREEKLCPISELISARTCRFTDTIIYCDARESEAHGMAMIELRLAAQDVEGSRLAKDLETSFVEGLGKAVELQAGIKASQMLHQIRLNYLEKVVNSGTTQDVQKWFGMIRSIASHARGQNPAVYKILREERNWGVYILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDA8</accession>
    <name>A0A317XDA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OTU-like cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_580433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473365.1">
        <property type="nucleotide sequence ID" value="XM_025615328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDA8"/>
    <dbReference type="STRING" id="1450535.A0A317XDA8"/>
    <dbReference type="GeneID" id="37117471"/>
    <dbReference type="OrthoDB" id="409956at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22756">
        <property type="entry name" value="OTU_OTUD3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF7">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="67"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="470" mass="51920" checksum="B0033623FF117E13" modified="2018-10-10" version="1">MADVPNGGRIVPIVTTARQHYSSSPTNEVMVKTPQQPSEKVKLPRNTRSKTMEAETLEIPCLNELGLYALPTEGDGNCLYYALSDQLYGDFTHADQIRDRLADHISANKDYFMSFIAAAGGERRAPRRAAAAAARQSYCSSSSSSPAPPSAKDKERSFDSKVAESRKKGVWGGAEEIQAFCQSFKRDVNVYTMYGIQNFRDVHAPATEEREIVHIAFHDFHHYSSVRHSDGPHTGLPCIPKVEKEREKEASAAKPTIVDMATPWKISAIQAGLGGKFDQSAIVEMLQQCRGNIDRAFMNLLGEDNNTSLADAPSSKAIMKSRLQPSSRSSSPFSTGSKRSADESDADDNPRPAVRRTRARENKRRILPDVTVGIAFRDDQNDLVSLRLRVSPETVVQTPTIRPTTEQAETSSFESATDSPDLLAQDKKLRIRPKVAPSETPSQSNDSSDDRKPPRRSQRLSRSRTAPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDK6</accession>
    <name>A0A317XDK6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_9053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473176.1">
        <property type="nucleotide sequence ID" value="XM_025617736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDK6"/>
    <dbReference type="STRING" id="1450535.A0A317XDK6"/>
    <dbReference type="GeneID" id="37119879"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF694">
        <property type="entry name" value="AMINO ACID PERMEASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="51"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="471" mass="50563" checksum="EB292B2C034EBED0" modified="2018-10-10" version="1">MSYFDESKDIKVAPVQDPSEDIGIANSSELKTSDESHEVFKRGDGQVDFRTVSWIRASAIFLKMLFATGILSIPSVMYDLGAFPGAVNLVGWCVINAYGAIILGRFRTLYPQCHSVADMAQLTGGPILRELVGFMFIVTYVITAASGIIGVSAAFNALSLHPLCTVWFAFISTIIIAGFASVRKFSHIGWLTWVGFASILAAVLIVVIGVTTRSRPSIAPQTGPYDLGYRAIGNPTFAAGITASATIFVSSAATSAFLPVISEMRKPKDYPKAVYLCMTFVTASYLAFSLVIYRWCGQWIASPALGSAGPTLKRVAYGIALPGLIVSGSLYVHVAAKYLFVRILRHSQHLQANTFIHWGTWLGCTIGLAAISFILACAIPIFTYVLALVGSLGFAPLALCLPGCLWVYSHGHYWRGGLVKQVVYLLHVGLIVLGVFLTVGGTYGVIVQIMDAYKSGEIDGVFSCADNSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDM0</accession>
    <name>A0A317XDM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CorA-like transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_592680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473477.1">
        <property type="nucleotide sequence ID" value="XM_025616155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDM0"/>
    <dbReference type="GeneID" id="37118298"/>
    <dbReference type="OrthoDB" id="5396681at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058257">
        <property type="entry name" value="CorA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26616">
        <property type="entry name" value="CorA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="CorA-like transporter" evidence="6">
        <location>
            <begin position="28"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY96716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="451" mass="51418" checksum="62380C433F45AFFA" modified="2018-10-10" version="1">MSASSARDIDGGHYESVLPYLRYPPLIDPSERSEIRLVDFASEDASRHDKQFTDSERFECHISTKAKPHARIVSICSRSSITPLQITERALRWLMKLYEIDADFFDIVVSFGDKPRNSDAGLGEMKVKQRADGSYDMQYLLTHADEYKIHGSTKWTIRQIGVFHRYNPSGDGNIWIFLHAKPSSKLQLQLEARLSEYTSALWQDWFSLHSLVLSSYLVNWRWCIRGLGDQLENSANIALTRDLSKSEGIDQNVLLELLKPQHLGDVILPLSSWMGVAQATVSKMQEINTLLYSKNVSTEDNYDRVTGDLASYKVNLEGHLRSVRVLERKAQGISDLLAVALSQRNQAVIIDINQSMLKLTDEGFDDNATVKVVTLVTLIYLPASFVSTILGMNLFDFGNGKLSISRQFWIFIVLAVPLTLLTLAMWYFVTQRQLRNRQKMKSKRKEEELMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDM1</accession>
    <name>A0A317XDM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_216294</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471779.1">
        <property type="nucleotide sequence ID" value="XM_025606194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDM1"/>
    <dbReference type="GeneID" id="37108337"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="97" mass="10935" checksum="746489D6E3F5A646" modified="2018-10-10" version="1">MNLSTQPRNGGFRTRKLSSRATARGVNVVMTRYQSFDGSDPEASKVLQLKRYLRTAMEREQPAATVQAGSWIHIYVTKLEKSKPELIHLTSPVEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDY2</accession>
    <name>A0A317XDY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_619646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473296.1">
        <property type="nucleotide sequence ID" value="XM_025616878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDY2"/>
    <dbReference type="STRING" id="1450535.A0A317XDY2"/>
    <dbReference type="GeneID" id="37119021"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="56"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="395" mass="44125" checksum="081B5F8503E80235" modified="2018-10-10" version="1">MTLTLSSEQRQALLDGPAASPPPGVIPNLVDPPNLQAVGRALILVFWSLALITFAIRIYTKVFIIRSVRVSDYTMIVAWALSIGYFPIAWKVADIAPGIDQWNLQVKNLIGLLHWFHSGLVMYSIIICFIKVSILRQFLEIFSLKRDYFFWTCHFLICINILYYTAFTFTIIFACNPISKYWDVLNTDGKCLNTELQMFVAGIINMISDLTILILPHLKVWRLQMSPRKKRAVSVAFLFGLIACVGSSLKIYYAVRLLKTKNNQSYQIYLLGVCTLPEIGGGIIAGCLPSLPKFFRHVLQTPLLSSYKFYVSKLLSASSRWSSSSTVARSAGNSAGGDQDRDRDLEAAKKKKIQFDDQYPLTSVVSCPGSETVDGSVATIHSTQEFTMVSSRGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEE1</accession>
    <name>A0A317XEE1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_224559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472069.1">
        <property type="nucleotide sequence ID" value="XM_025606244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEE1"/>
    <dbReference type="STRING" id="1450535.A0A317XEE1"/>
    <dbReference type="GeneID" id="37108387"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="514" mass="56515" checksum="588F362960EAB270" modified="2018-10-10" version="1">MSPKTSHDIERDLDKSHVDNVEVVPNAVANADRPNPKKEAPAYVAGLTPEEREKAERALVRKIDLRLLPMIIIMYILNYLDRNNIAAAKLAGLVSDLNLVGVEYQTCVSILFVGYLLMQIPSNLLLNKFGKPALYLPGAMMLWGIISTCTAGAQSYAGLVTVRFFLGFVEAAYFPGCLYFLSAWYTRKELGFRTAALYSGSLISGAFSGLIAAGITENMDYKLGLRAWRWLFIIEGAITIVVAFLSIFILPNFPRTTGWLTEEEKELAAWRLEEDIGEDDWVDSEQQTFLHGVQLAFTDIKTWILMLLILCIVSSASVTNFFPTVVKTLNYGNIETLLLTAPPYCLAVICAFANAWHADRTGERYFHITLPLYFSVAAFIIAATTTSIGPRYFSMMLMVPSLYTGYVVALGWISSTLPRPASKRAAALAGINCVSNASSIYASYMYPDSDAPRYITAMSVNCVTAFVAILSATALRFILVRLNKQLDRGEGISGAVSSGGIPGQASSRGFRFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEF6</accession>
    <name>A0A317XEF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_530742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472788.1">
        <property type="nucleotide sequence ID" value="XM_025610736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEF6"/>
    <dbReference type="STRING" id="1450535.A0A317XEF6"/>
    <dbReference type="GeneID" id="37112879"/>
    <dbReference type="OrthoDB" id="4358740at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="154" mass="17323" checksum="6508398C573A033B" modified="2018-10-10" version="1">MTEQKPQRVLVIVSESNSYWEQSWSSSEDLLPIAFDILSDNHLLEGTYNEQPELKLLVKQKWATHVFLIFDISNTSYDPTLGHLPEQNKLPITIIRLGKKVQAYSASAPVGNKVNSNVARVHNANGVNSFPPFVTDYTIKSPLYSNPRDPSLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317URK3</accession>
    <name>A0A317URK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Senescence-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_561678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000106">
        <property type="protein sequence ID" value="PWY63856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317URK3"/>
    <dbReference type="OrthoDB" id="4378253at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY63856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="118" mass="12958" checksum="D1873C0920233912" modified="2018-10-10" version="1">MIGRADIEGSKSNVAMNAWLPQASYPCGNFSGTSSLKFRGTKGSIGHTFMVCIHTENQNQGDFYPFVLLEISVLHESPLGHLRCAKLPPDNVFNPDRPAKDLNARRWAVKPSSASLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317USJ2</accession>
    <name>A0A317USJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_615494</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000065">
        <property type="protein sequence ID" value="PWY64964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461339.1">
        <property type="nucleotide sequence ID" value="XM_025616756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317USJ2"/>
    <dbReference type="STRING" id="1450535.A0A317USJ2"/>
    <dbReference type="GeneID" id="37118899"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="43"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY64964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="541" mass="59804" checksum="D4E872540214AA1E" modified="2018-10-10" version="1">MDRSSTPEKKPHYIDEEDGDLEAAAASQLDEAQVFQQGLHQRHIQMIALAGTIGTGLFLSSGRAIAHAGPLGAFLAYSIMGLAVSSVVFAVGEMGALVPLAGGVIRYAEIFVDPALAFANGWNQIYSYLVSIPSEIVAAAVVIEFWTTINNAIWITVFGLLMLITALLFVRVYGELEFGFSILKIMLVIGINLMALVITCGGGPNHTSIGFRYWRDPGPFVQYLNIGGSLGRFLGFWTALNSALYSYSGIENITIAASETRSPRRSIPMAARRIFVRILLFYVLTMFMIGLVVPSNDPDLLGSSGTASESPFVIAARNAGIKVVPSIINAVVLTSAWSSGNSNMLGGSRVMYAMAAEGHAPKWFMRMNRFGIPWVAVTILGIFMALGYMTLSSSASTVFTWLQDIVSIATLVNWGCICIVYLRFYYACKKQGIDRHKELPWAAPFQPWSTWITLGLFSILFLTGGYTTFIHGHWDTETFISSYLNVPIIFVLYFGYKLWMKSKIIPLEAVPVRPFIQHYQENPEPEPEPKRGWQRLNFLWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UUT7</accession>
    <name>A0A317UUT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_540841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000058">
        <property type="protein sequence ID" value="PWY65365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461431.1">
        <property type="nucleotide sequence ID" value="XM_025612999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UUT7"/>
    <dbReference type="STRING" id="1450535.A0A317UUT7"/>
    <dbReference type="GeneID" id="37115142"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY65365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="272" mass="29172" checksum="1AC4858E8E371CC1" modified="2018-10-10" version="1">MSALVEVASEAEFPTIISSLPPSCLQVLYFHAPWAAPCAQMRAVLSALASQYPATTPPSIAFLSVNAEELPDISEEYNVTAVPFVVLVRDNKILETISGSEAIQVRDAVERHAGAAAADGLPKTTIIPPPLTAVPRENAPTTATQAPANGTTAAPELTPEQSKEALFARLAELVKAAPVMLFMKGTPSSPQCGFSRQLVGILRERSVKYGFFNILADEDVRQGLKEFADWPTFPQLWVEGELVGGLDIVKEELENDPEFLGRFSVNKAPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVI0</accession>
    <name>A0A317UVI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_504739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000057">
        <property type="protein sequence ID" value="PWY65635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461471.1">
        <property type="nucleotide sequence ID" value="XM_025609519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVI0"/>
    <dbReference type="GeneID" id="37111662"/>
    <dbReference type="OrthoDB" id="4153865at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY65635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="101" mass="10396" checksum="E51839DB278145E5" modified="2018-10-10" version="1">MFGNGLMSWLRLSSEMAVPESKWDPATLTMQPASPSAEHVITEQPRTGESMQLQIRGGGEGEDVCCGVCAGLCCFECCECCCGGDDGPPGPPGPPGPPGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UW66</accession>
    <name>A0A317UW66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_614143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000056">
        <property type="protein sequence ID" value="PWY65659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461486.1">
        <property type="nucleotide sequence ID" value="XM_025616722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UW66"/>
    <dbReference type="GeneID" id="37118865"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY65659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="212" mass="22691" checksum="3302AA949C725DB3" modified="2018-10-10" version="1">METLKSVRKWAGVRHNAVAWLAFCIGIFCCTFSLLVPYDYLPSMANQAGMNLDLAQYTLSITNAESMIGRIVPGFLSDYMGQFNIMVLVSAFSAVAQLAIWLPVYYAPTNAGFIFFAAFYGFVSGGYTSLLSPCVVALVDGRVADLGLKFGVACLYLAFGALVGIPASGALVDDSENWESLIALSGSIMAVGALCFVVARVKKGGWDVMKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWX7</accession>
    <name>A0A317UWX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_591162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461721.1">
        <property type="nucleotide sequence ID" value="XM_025616092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UWX7"/>
    <dbReference type="STRING" id="1450535.A0A317UWX7"/>
    <dbReference type="GeneID" id="37118235"/>
    <dbReference type="OrthoDB" id="408320at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051913">
        <property type="entry name" value="GH2_Domain-Containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006103">
        <property type="entry name" value="Glyco_hydro_2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006104">
        <property type="entry name" value="Glyco_hydro_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732">
        <property type="entry name" value="BETA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42732:SF4">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02836">
        <property type="entry name" value="Glyco_hydro_2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02837">
        <property type="entry name" value="Glyco_hydro_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolases family 2 sugar binding" evidence="5">
        <location>
            <begin position="20"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 catalytic" evidence="4">
        <location>
            <begin position="363"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY66523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="654" mass="73150" checksum="CAE8A3F8997509DB" modified="2018-10-10" version="1">MIMPAYPRPDFHRPNLNWLSLDGPWNFLFDDADRGLTDRWHHEGLPTQAASHARRQIQVPYAFQTPASGIGLHEVHEVLWYERTLPDIRFSDEHAQGNRLVLRFGAVDHECTVWVDGQLVGGHRGGHVPFDIDVSDAFRAQGNNDPHRLTVRVTDSASDLGQLRGKQYWGPVPQEIFYTPTSGIWLSVWLESVPPARLGSSSEGTVLRSDDIHGGHLHARVAVLGRSVAGECVVEIEASLAGTLVSSSKQSLPRDKDWVNLEVDMRVPEPSSLMGTAPFNRDDCWQGRVALWGPDHPILYSLTLRLYDASRSLVDVVATTTGMRSISWANGDGTFRLNGRPCFQTLVLDQGYWPDTGLTPPSQEALRADIEMAKKMGINGCRKHQKVEDPVFHWWADQLGFLVWGEIANAYEFSDEYVDRFNREWVEAVRRDINHPCIVAWTPFNESWGYPSLKDNIDQRNHIRSVYYLTKTLDPSRPINDNCGWEHVVTNLTTYHDYSDSPALAASCADFEGGILSKKSNRDMFVGPITSKPSGLLDPGARHTPGAPVICSEFGGVNIIPAKGTEAGERDWGYTTAADPEDLLSRLERLVMAVVKGGHSCGLVYTQLCDIEQEVNGLYSYDRKEKVPAARVKAIMDAAHQYYHEHVAPKSTHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXF0</accession>
    <name>A0A317UXF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_480307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000061">
        <property type="protein sequence ID" value="PWY65207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461374.1">
        <property type="nucleotide sequence ID" value="XM_025608787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXF0"/>
    <dbReference type="GeneID" id="37110930"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY65207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="8829" checksum="7A73A688383784EC" modified="2018-10-10" version="1" fragment="single">INRIFKHLIIFYDITYLSTIFFFRIYKKVLIKYLNKFITIYINNILIYSNNTTEYKLYIQLVLKKLQIVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYJ0</accession>
    <name>A0A317UYJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_591079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000050">
        <property type="protein sequence ID" value="PWY66825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461761.1">
        <property type="nucleotide sequence ID" value="XM_025616084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYJ0"/>
    <dbReference type="STRING" id="1450535.A0A317UYJ0"/>
    <dbReference type="GeneID" id="37118227"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY66825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="515" mass="58419" checksum="EAA810A1ADDC8C92" modified="2018-10-10" version="1">MLVPAIVLLGAIYLTFKVLRSLQQAYSDRKKAKALGCQPSKVVPTGFLGITGFIRIVKAAREKRWVEYIAEHYQSYGSTFHQTALGGLIIHNTIEPENIKAVLAIQFQDFSLGTRHREFYPLLGNGIFTLDGAGWSHARGLLRPQFTRDQVADLDLMDGHISKMINLIPKDGSSFDIQRLFFLLTIDSATHFLFGESVGSMRTSTEASLLEKSAVGSAQGFAEAFNLAQEYLASRSRAMAFYWMVNPKEFQEASRLVHEVVDHYVQLALESRRHPEKKEAGRYIFAEALAADNDDPRVLRDNMLNILLAGRDTTASLLSSAFFYLARHPNVWTRLRRTIVQEFGDAQRPEGKITHARLKDTPYLRYFLNEVLRLLPPVPLNFRVAVKDTSLPLGGGPDQKSPVYVRKGELVAYSVYAMHRRTDLYGPDAHIFRPERWEENSKRGWDYLPFNGGPRICLGQQYALTEASYTLVKLLQRFDRIENADPDLMEPIIQSSLTLSHDRGVNIRLYSSEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0N3</accession>
    <name>A0A317V0N3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_503721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461964.1">
        <property type="nucleotide sequence ID" value="XM_025609488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0N3"/>
    <dbReference type="STRING" id="1450535.A0A317V0N3"/>
    <dbReference type="GeneID" id="37111631"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33099:SF7">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="297"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="657" mass="72291" checksum="9DA40359D9250F97" modified="2018-10-10" version="1">MGQVRLFPNRPSVDKNKGHDAVSAILTQLETWAKERMDEEGNMDPCIDKFLVGVLKLDPSQRHRFSPDLEAVKAANASEMQRLAFNLKTSLDHQVPGYLDSALDVLDDPKLKPKFSQRWDAVGKQLDQLDPTGSFGGTMLETLIALPQQPSKGKKKKTTGASALTSAAFTEACQQLREAIENETSSASFTCGGIIPINRTEGHSASDNTSSAVGVYWKTQDKSTTHSLDLPVTDNLTGPVGSLIADCQPASFGRGGEDILDPEYRRAGKLDPGYFATTFHPADFGIVDIVERTLLPDISSMRSRKLRVELYKLNVYSGPSGHFRKHVDTPRSEHQIGSLVVCLPCEFEGGNLVVRHNGQETNFDWSPQSGSTIQWAAFYSDCEHEIETITRGDRITLTYNLYVRDVTEMTERVEAEIGLSSTIQPRSLSLYGLVESLLGTPGFMKEGGVLGIFCSHAYPHASDKTGLQLPQAFKGADLVVYAVLKSLGFKVSVVPILELNGSFGPGNDALGITGQIKDAKLRYEHSYSPRPSSGKLTWMLTTQPILEGMDIFRNKHDLPTPPARFNKAEGTRVGPEFRKYFTTETGGWEEEDIDVIGAEVWPSYYLPGITWITEPKHEEMAFTHMTYGNEAGLGTRYSCAAILAVIPPFSVRSQPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2R4</accession>
    <name>A0A317V2R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS amine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_628937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461804.1">
        <property type="nucleotide sequence ID" value="XM_025617520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2R4"/>
    <dbReference type="STRING" id="1450535.A0A317V2R4"/>
    <dbReference type="GeneID" id="37119663"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="13"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY67082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="440" mass="47441" checksum="0CEB7DAA2046A8D7" modified="2018-10-10" version="1">MSVQKLRSSTPFAVIVVCVAVFTDIFLYGLVVPMLPFALADRVGLSDGDIQRWNSILLATYGAAIMLGSLLFGWMGDQTRTKQLPFLLGVGVMGGATLLFSLTTSLLLIILARVLQGCSTAIVFTIGFSLLLDTVGDRHIGRAIGFTSMSLSVGLFAGPIVGGFLYDLAGYFAVFIPAFVLVALEFLLRMLLITPRHDPEVKQPITDEDQRPLIPGTAGRQSPRTPAVFTLMRTPRFAVAMLGMFMLNSFMTAYEAVLPVYLPEVFFYRSTQIAIVFLSNTLPMICSPVGGSLVDHLGPFWPAVLGFGLITPSMMLLSLIRVPGTLHSVLLRLFLFLFGCGVSVAMPAMMTEITLAKDAMEEGEPGIFGDRGACSQAYGLSNAAFAGGTLVGPLYAGYMREAAGWTAMNISLGVFSGLMVVLIIMFTPRKRPGVVRRTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3B6</accession>
    <name>A0A317V3B6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_301053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462189.1">
        <property type="nucleotide sequence ID" value="XM_025606747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3B6"/>
    <dbReference type="STRING" id="1450535.A0A317V3B6"/>
    <dbReference type="GeneID" id="37108890"/>
    <dbReference type="OrthoDB" id="5223589at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF6">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G07550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY68526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32918" checksum="D83B4EBA0764D772" modified="2018-10-10" version="1">MQPYTPDDIDPSPPRTTNTGHLRFAEDKGGLWSSGNSTNVSFSVNQREETIYGTITRHFKADIDRKYADWMLVVCGFVGGLVDGLSFNAWGSFSSMQTGNTVFLALGASSQPRYPAYLWAKALISLCTFMTSNVLFIQVSRKLNPLRRSTMVLSFAVQTICLLTAAILVEAQVVSPKPEDPRAPIQWMQIIPISLLAFQAGGQICASRILAYDEIPTVVLTALLCDLLVDPELMVKKNPKRDRRIGAFLALFLGAMTAGGLVKVASMASSLWFAFGLKFAVTLGWIVWRADGRGKDNGGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4V6</accession>
    <name>A0A317V4V6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_478450</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462130.1">
        <property type="nucleotide sequence ID" value="XM_025608687.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317V4V6"/>
    <dbReference type="GeneID" id="37110830"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041285">
        <property type="entry name" value="MID_MedPIWI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18296">
        <property type="entry name" value="MID_MedPIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med13 N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="MID" evidence="15">
        <location>
            <begin position="979"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="Mediator complex subunit Med13 C-terminal" evidence="13">
        <location>
            <begin position="1159"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="399"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="614"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="698"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="915"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1320"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="742"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="915"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1320"/>
            <end position="1339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF11597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY68108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1484" mass="161512" checksum="E2DEB8069563F1D1" modified="2018-10-10" version="1">MDFPGGSITNIRVIDGFSQIYWRIYTEEPNSANTPGESPANGYTILKHLSRLKDLELQIRDRDCLVSSYPRRLCLWVFSATPGFESLLPLSANEAKDDSSRLAIGSATMKASSSGNVSSLDLVKNLSTEPQNAPGTTGPQRQNALTPYATIYASFISAVSGAVSLQLVRQRNAIPLGSRTLFTAVERDSYDCFVKNDPLSASSLITLQIQLTSVGKLTVALQTVSQAGLRRLLAPEDDPAGIHDIPPGTDLWLSPSGSISRLVAANLSRLNAASPYPSSAGGPGNDKSSMATRKQWKVNVLWWLANFGLPVDEIDEEAWVEVEVWEPFYSRLAGEIGRSNDESSSTLPLKRILWPAIYCFKRTKSASSDSYGELDSVGPVLGDPLDFAEKWRVTEKPTFIEASPKPSSVHQEPQARDQDALSPDMPNLPEGIESLSRASQYPELQTASLVYPTPPDGAAATGLNPTVPSDVFPDDLEQGSSFMQSSRQNYHGQLNKDRTGAEVISFGPSAGLVVGSGLYDTNDDDDLFGDINERDFGSKGLTDADFSFFDDPDFDHVGGGGGEQEDPIHAMSDFMDTDEPELQPTVDEQASPEQTPAMDIDSSRISPVVEAADLQQEKAVPEAKTPVSSPRDGKPRTISPPLSPVEVKKILFPEPHIGSQHLVKQGQMPGYYNAVAFKQNMSLWDRKYSAEGKFGFTFRGREGPKGADAATSDIPTIGLPRRSGKLKSSTSKEPDSQASPTSGMQASSSDTDSSSDASVESDESGSESGLSPATSSTRKRKRTRSNSGTSLALSQDKAFVRADQETTPQRPEDSVFLGNFLSTFSDWSMAGYFSLAQNQVSPVLIRKDIQVQIAQLLVDQVTQSSLDHKIDGNLGLSDYDDEAYSLQTQLGDAAFVGGMERLDLNGFVSLQDASTLSPPTSNGPNPRQSSQRKEAGKGTILKIPPPHLRVCRGKDFLETLPPAISFWETFGLEPAHGQKDIFAYCIHPHFAAEAADAFLERLGLVYSGCNLGSHTRGERSNFFDRGLGSWDISPSEDSRYFEVMQSLKTICGVLGSAFLNTPPSKDSNLVVYIVNPFTHAAALVDICSAFWSLFQKYIADADKQQARQLNELVLQIIPIDFVTATGSLVVPPQADYLNLALEVYSRCPPKSTQPSLINCAPPVLLAEPLPRSIGFKLSSEGSSPLQEGKCLHIACSRSLDQRWISVAWSDNFGALQRNMSYCLRFRNSLMTRPLVEVRSEIWKATRDIMDRIQARWRVVIVNTDPVDQEEVDTWSNFADQYGKARSITLDLVILSANTTPDLYLEPPFLPVPLSVFNQQSSSTPVATPNLGGSVSSPDQLGNAPTPPGGLGVPANASTPTDALPEIESESLITDIYDETWGVVLSHRLNSSLHQTEYRPALASGYLLRRKGSTDGDGLYTMSVNILHARRSPSSYDTLLREILGMYRDLATLARARGTRTVQQGTLPWHVATAVKAQTMLSYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V553</accession>
    <name>A0A317V553_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_478583</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="13"/>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY68007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462056.1">
        <property type="nucleotide sequence ID" value="XM_025608695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V553"/>
    <dbReference type="STRING" id="1450535.A0A317V553"/>
    <dbReference type="GeneID" id="37110838"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="PA14" evidence="14">
        <location>
            <begin position="407"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY68007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="842" mass="91910" checksum="5B5BCE35AB35463C" modified="2018-10-10" version="1">MAAPETDKSFTQIESANVEDLIQQLTLDEKVALLTGDDFWHTVPIPRLGIPSIRLSDGPNGVRGTRFFGSVPAACLPCGTAIGATFDRDLAVQIGHLLAAEAKAKRAHVVLGPTINIQRGPLGGRGFESFSEDPLLSGIMAGHYCKGLKEKNIIATLKHFVCNDQEHERMAVNSIVTDRALREIYLLPFMVAIALGKPEAIMTAYNKVNGVHASESPALLQDILRGEWGWEGLLMSDWFGTYSTSEAIHAGLDLEMPGPTRWRGSALAHAIAANKVSMATINARVRAVLKMVQKASRSGIPERAPELQLNRAEDRRLLRKIASEAVVLLKNDDGVLPLNKTKKIAVIGPNAKIATYCGGGSAALNPYEAVTPFAGISNSSSGGVEFAQGIHGHQNLPLLGKRLRTQDGLTGFTLKVFNDPPTVSDRTPLEVRHETDSMVFFLDYNHPELQPVWFADAEGNFIPDESGIYDFGLCVQGTGKLFVDGNLLVNNADIQRPGPSFLGSGTMEERGTMELVAGQQYKVHVQWGCAKTSKFKVPGVVDFGHGGFRFGACRQLPPQMGIEEAVKLAASVDQVVLMAGLSAEWESEGEDRTSMSLPPYTDELIARVLEVNPETVVVIQSGTPVEMPWIKDTKAVLHAWYGGNETGNGLADVIFGDVNPSGKLPLTFPRHVKNNPTYFNFRSEGGRVLYGEDVYVGYRFYDETEIDPLFPFGHGLSYTTFELSGLSLMRHSNTLQATCTLRNTGSRAGAEVIQLYMAPVSPPIKRPLKELKEFRKVWLKSAAETEVTIPLDLVRATSFWDEKSGSWCSHSGTYRVMIGTSSRGEFLESSVELTETTFWSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V577</accession>
    <name>A0A317V577_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_551179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY68002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462051.1">
        <property type="nucleotide sequence ID" value="XM_025613531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V577"/>
    <dbReference type="GeneID" id="37115674"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="179" mass="19782" checksum="F65BD9A18B24C235" modified="2018-10-10" version="1">MSWIAVLAWLREIKPQVGRGKGASPVDCERVLSMSSPSIGGEWKAAGESFLIEHHQAAGRFRVTCAHGVKQSTKSDSTTGGYSQSREQKQDEVFARSQLPTDQMLSVSLAWRNSPMNLQLGCTKCHANINVLTIGQCPEEQFRSLLLHGLILEVFLCHGFDVDEHTCIMVLQAQEARSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6D5</accession>
    <name>A0A317V6D5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">SCO1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_628635</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SCO1/2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462160.1">
        <property type="nucleotide sequence ID" value="XM_025617496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6D5"/>
    <dbReference type="STRING" id="1450535.A0A317V6D5"/>
    <dbReference type="GeneID" id="37119639"/>
    <dbReference type="OrthoDB" id="270009at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000013">
        <property type="entry name" value="Blast:Protein SCO1 homolog, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017276">
        <property type="entry name" value="Synth_of_cyt-c-oxidase_Sco1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151:SF5">
        <property type="entry name" value="AT19154P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037736">
        <property type="entry name" value="SCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="118"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="156"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037736-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR603782-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY68497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="296" mass="33670" checksum="E3B06A123A2FE9BE" modified="2018-10-10" version="1">MASTMRPMSRILTRASRSTLFPIERTATQTALRTTTTSPISRLSSNNAILSSTRSFSTSPACLRARTMGQMKARHSTGPFSWKSALLFVLTGGGMIIYFRVEKERLERKRIAEMSKGVGKPRVGGPFTLKDLDGKEFTAEDLKGKYAFVYFGFTHCPDICPDELDKMAEIIDKVKEATKGENIFLPVFITCDPARDTPEVLREYLKEFHPGIIGLTGTYDEVKNVCKQYRVYFSTPRDIKPGEDYLVDHSIYFYLMDPDNDFVECIGRQDTPETATRTIMEHINDWKREGKPLRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8N8</accession>
    <name>A0A317V8N8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462417.1">
        <property type="nucleotide sequence ID" value="XM_025612836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8N8"/>
    <dbReference type="GeneID" id="37114979"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="95" mass="10170" checksum="913BD243BC9F9536" modified="2018-10-10" version="1">MSPTLTRPTPTTLLTPSTTTTTTSSSSSSTSPTTFSQDISRAILSASSHIPKAVVDPTSTTTSAPCHTEKNTLEWEFPLPPPPPPSPVEMRRFWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VAY8</accession>
    <name>A0A317VAY8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_257684</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462911.1">
        <property type="nucleotide sequence ID" value="XM_025606468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VAY8"/>
    <dbReference type="STRING" id="1450535.A0A317VAY8"/>
    <dbReference type="GeneID" id="37108611"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001297">
        <property type="entry name" value="Zinc finger and SCAN domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001289">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="379"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY71513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="447" mass="50068" checksum="A8A68E0243F051A0" modified="2018-10-10" version="1">METAEPVSYEFPGHPVGAVAPRRMMNSNVGHNFSFYTNPTAPFPLPFHQSSSAAYGFGHTLNHHHHHHHHHPGYQHYFVAGQQPLHHQPVRLSSEPPSIQQIPDIRPAKNAVNRVARDPLTKIEHNTSSQQPPGAQQSINGAAAQGKGSSTTEVEFSTEVDILMKAIQAKTGTQPPGVQSLPPLQQLTHGGSNGYTQSYSIPVTTPRCTVMVEEAPSRPGKKRKYACTLPHCGKSFAQKTHLDIHMRAHTGDKPFICKEPSCGQRFSQLGNLKTHQRRHTGEKPFSCDICQKRFAQRGNVRAHKITHQHAKPFTCLLDDCGKQFTQLGNLKSHQNKFHATTLRNLTLRFSQVTEGEHMSPQDRKLWEYFATLYKNSNKGIKGRGKDRRISPTSRSDHGSDSRRRIQPLSSNDDKLRRASYEDASIYNGGSSSEEEDAEPYFIERQAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDY7</accession>
    <name>A0A317VDY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_251007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463118.1">
        <property type="nucleotide sequence ID" value="XM_025606435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDY7"/>
    <dbReference type="STRING" id="1450535.A0A317VDY7"/>
    <dbReference type="GeneID" id="37108578"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="262" mass="29633" checksum="92751B4949366A24" modified="2018-10-10" version="1">MSTPFLDPSGNSISEDQLLGYGRSGVVILKDNAAIKLPLRYLSTSDDEVLDNITVIQREQNVYQHLGHCTRVVPYISFSEKTTHLAFMENGDLRSYLSRNKQPPSKSLQLSWFRQMALALSHIHHRSVIVADIACRNILLDSDLSIKFCDFTEATIMPPDSDLETVDDNGYSIQTDIGQLGKVIYEVVTGKKCLFDLHENNISRATLPRRETLPTTHDIWLGHIIEKCWIPGTYRNATDLLKELNTISLNDINSNSKYQPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VE21</accession>
    <name>A0A317VE21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">116 kDa U5 small nuclear ribonucleoprotein component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">U5 snRNP-specific protein, 116 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_475824</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463320.1">
        <property type="nucleotide sequence ID" value="XM_025608579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VE21"/>
    <dbReference type="STRING" id="1450535.A0A317VE21"/>
    <dbReference type="GeneID" id="37110722"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="137"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY72546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="990" mass="110230" checksum="41758BA6DC6E38E8" modified="2018-10-10" version="1">MDDLYDEFGNYIGEVDGSDEESPHHDEANAQAFAFEEAFGGDNEDDPDDVGEQQLMDVDDEGPSNAVVLHEDKQYYPSAQQVYGHDVETLVQEEDAQPLSEPIIAPVQQKKFAIEEAELPPVYHSREFMTDLLNFPDQIRNVALVGHLHHGKTAFMDMLVTETHDLTSRLEKRAGRRNEEQLRYTDVHFLERERGLSIKAAPMSLVLQGTKGKSHLFNILDTPGHVNFVDEVAAACRLVDGVVLVVDVVEGVQANTEQIIKHAILEDLPLTMVVNKMDRLILELKIPPNDAYFKLKHVIEEVNTIIENVLPGHGAARRLSPEKGNVAFACASMGWCFTLHSFAKMYAERHPQVDAVDFCLRLWGDIFFNPRSRKFTRKGVEEYSKRTFVQFVLEPIYKLYSHTLSESPEDLKQTLASVGISLKPSQLKSDANSLLNLVCEQFFGSATGFVDMLLQHVPSPAEGAQRKLERYYTGPLDTKLAAAMAACDSDGPLIVHITKLYNSVDGSRFHSFGRIMSGTAHPGQQVRVLGEGYTPDDEEDMVTATISDTWIAESCYNIPTSGVPAGNLVLLGGVDNSIVKTATIVPLHLEDNEDTHIFRPIRHITESVFKVAVEPVNPSELPKMLEGLRKVNKSYPLISTKVEESGEHVVLGTGELYMDCVLHDLRRLYSEMEIKVSDPVTRFCETVVETSAIMCYSITPNKKNKITMIAEPLDEGIAEDIESGAVNIKDPIRKVAHFFEERYDWDKLAARSIWAFGPDEMGPNILQDDTLPSQVNKKLLGSVRDSITQGFSWGTREGPLCEEPIRNTKFRLTDVSLADQAIYRGGGQIIPTARRAIYSSFLMASPRLMEPIYSCTMTGPADAVASVYTVLSRRRGHVLSDGPIAGTPLYSVRGLIPVIDSFGFETDLRIHTQGQAAVSLVFDKWNVIPGDPLDRDVKVKPLEMAPAMATARDFVLKTRRRKGLAEDVTVSKFLEPELWKGLKESGVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VEF3</accession>
    <name>A0A317VEF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_525983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463065.1">
        <property type="nucleotide sequence ID" value="XM_025610337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VEF3"/>
    <dbReference type="GeneID" id="37112480"/>
    <dbReference type="OrthoDB" id="202415at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF112">
        <property type="entry name" value="DUF821 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G14740)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="167"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY71829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="442" mass="50191" checksum="6B87BF9D52EDC33B" modified="2018-10-10" version="1">MQLLQGQSSGFRFLATGAVLSLIITTFIIFGTRYSNDVAKYALKAPLKSAPQSCSHLPQLTPVNDSKWEFMVERDGDNHGLSDTQCRLAFPKFFVELDKSVSLREGSRITFKELDGLEVGDGMVRGIIDRGELHIVDFGAMPATFTRGKATLHAINRALASFPDRDTLPSIEFVLTTEDYSNSEGPIWSYSKRDEQENVWLMPDFGYWSWPEVKIGPYKEIRRRIAAVDDGEATLDGKFAPGLSFQDKKKQLAWRGSVATSPEIRGKLLKAAQGRSWASIRVIDWDDENDVRFNLLPMEEYCQYMFLAHTEGRSFSGRGKYLLNCRSVVVSHKLVWREAHHAALIASGPEANYVEVERDFSDLDRKMAFLIDNPEAAQRIAENAVKTFRDRYLTPAAESCYWRHLIRQYASSCEFEPVLYTQENGRRQPRGVPFESWVLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VER6</accession>
    <name>A0A317VER6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">4-nitrophenylphosphatase</fullName>
            <shortName evidence="5">PNPPase</shortName>
            <ecNumber evidence="3 5">3.1.3.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_526884</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Divalent metal ions. Mg(2+) is the most effective.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="3 5"/>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462661.1">
        <property type="nucleotide sequence ID" value="XM_025610368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VER6"/>
    <dbReference type="STRING" id="1450535.A0A317VER6"/>
    <dbReference type="GeneID" id="37112511"/>
    <dbReference type="OrthoDB" id="413953at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008967">
        <property type="term" value="F:phosphoglycolate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288">
        <property type="entry name" value="4-NITROPHENYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19288:SF46">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000915">
        <property type="entry name" value="PGP-type_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000915-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY70370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="318" mass="34603" checksum="CD57B5452A91ACC1" modified="2018-10-10" version="1">MATSAPAPEYPASTHTPRYLTGDGAGIREFIDKFDVFLFDCDGVLWSGDHIFPGTNETLEMLRSKGKQVVFVTNNSTKSRADYNKKLTALGIPSTTEEIFSSSYSASIYISRILTLPPNKRKVFVIGETGIEQELKSENVPFIGGTDPAYRREIAPEDYKSIASGSSELLDPEVGVVLVGLDFHINYFKLALAYHYIRRGAVFLATNIDSTLPNSGTLFPGAGSMSAPLIMMLGKEPVSLGKPNQAMMDAIEGKFQFDRSRACMVGDRVNTDIRFGIEGRLGGTLGVLTGVSSKEEFVGGEVRPSVYLDRLADLLGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHL2</accession>
    <name>A0A317VHL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_237716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463608.1">
        <property type="nucleotide sequence ID" value="XM_025606343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHL2"/>
    <dbReference type="GeneID" id="37108486"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="177" mass="18957" checksum="7F0B8CFD3AF5C3A4" modified="2018-10-10" version="1">MNPFIDGIYPAGASTPCRGYGTHGGLLEYLIPAQSTRSDSDLLNLAVRSAQSSASRMILPKDERVRTHQVCCMRSAAAVGDIWKGTCTNPQGQCTMVPNSIPVLRTEGFKISSAKTVSVPATECLKSQRPKDPPSILFCFDEISPSRNGRPPGCDREDSLSPGTPDHQRHSAAGKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VMQ2</accession>
    <name>A0A317VMQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_607757</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463465.1">
        <property type="nucleotide sequence ID" value="XM_025616547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VMQ2"/>
    <dbReference type="STRING" id="1450535.A0A317VMQ2"/>
    <dbReference type="GeneID" id="37118690"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF123">
        <property type="entry name" value="GMC OXIDOREDUCTASE (AFU_ORTHOLOGUE AFUA_2G01770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="486"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY73200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="544" mass="59116" checksum="BABEC42ECBB68C16" modified="2018-10-10" version="1">MAPRYDYIIVGGGLAGSVLASRLSKGPNRPKVLLVEAGPDVTKNDIIPYAKNLPFLIHSELDWAYATVPQKELEGRSINNPAGKCLGGGTAINVCGWDRGDGHDYDQWAELVGNERYSYQRMLPYFIRTEEYHDPNVTTGQHGSDGPLYIATAASTGRHYPLCDLLLQAWKENGVQPLDGLDGNSGNPTGLAELTENRRNGLRQLASSAYPLNRVGILTNTLVKRIVIEESTAVGIETAAGVHYYGREIICAAGSYRTPQLLMLSGIGPKDTLSQFNIPIKADISEVGRNLFDHLEMTQYWKLKDQYAGYAFGVHNPNFTKPQFGLGVPVDWIVKTDVPKEGLAKALAADGHADNHPLLRSQRAVIEHLVLYAAACPANPVISFDGTHIASTIVHLLPTSKGSVSINSTDPATNPVIDPQYLSTEADRYAWRMGLRKTAQLFLGTDAGKSFVEREVSPDAFRPITLDSSDEYLDSRTRHGAFSTYHPLGTCSMGKVVDTDFRVHGVSNLRVVDASVIPVPIAAHIQAAVYALAELAADVISGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VMW5</accession>
    <name>A0A317VMW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_474379</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463892.1">
        <property type="nucleotide sequence ID" value="XM_025608510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VMW5"/>
    <dbReference type="STRING" id="1450535.A0A317VMW5"/>
    <dbReference type="GeneID" id="37110653"/>
    <dbReference type="OrthoDB" id="5809458at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026928">
        <property type="entry name" value="FAX/IsoI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01180">
        <property type="entry name" value="SUF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01200">
        <property type="entry name" value="SUF1.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="2">
        <location>
            <begin position="21"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY75265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="264" mass="30295" checksum="2DADCB32F8BFCD8E" modified="2018-10-10" version="1">MSPKITLYRGFPTPGIYTWSPFVTKLEARFRFSDIRYSTEGGSIRAAPRGKIPYIRIEKPTSSGESTTEILSDSTLITRRYIEEGNFDDLNAHLGVKERMLDRGITSLLEDRVYFLQSHEKWIGNYYTMRAHILSSLPYILQVIVGQLIYRKQVSTLHGQGTSRYSDEERKEFKREIWGEINAVLVQARAEMITRQDGDGPFWLLGGDRPSEADATVFGFVVGAVICTACPETQGIVRGFPVVVEYARRIHERYFPEYQVWSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQ52</accession>
    <name>A0A317VQ52_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myb-like transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_432979</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464307.1">
        <property type="nucleotide sequence ID" value="XM_025607482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQ52"/>
    <dbReference type="STRING" id="1450535.A0A317VQ52"/>
    <dbReference type="GeneID" id="37109625"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF265">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="2">
        <location>
            <begin position="73"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="73"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="2">
        <location>
            <begin position="130"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="130"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY76494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="19267" checksum="CA792C5DD32CA894" modified="2018-10-10" version="1" fragment="single">WTAEEDRILREQVMSQGMKTTSLGDDSEDRAYIGVSTVVNAVGSVKDWNAIAARLGSRTNKDCRKRWSKLEGNVNKGVWSPDEDGRLRRAVEQYGFAWTVVAQDVQTRHADQCAKRWYHFLDPILIHDGWTAAEDARLIEAVVAYGRTWRVISEKEFPRRSVTDIKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRP2</accession>
    <name>A0A317VRP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_538732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463763.1">
        <property type="nucleotide sequence ID" value="XM_025612551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRP2"/>
    <dbReference type="STRING" id="1450535.A0A317VRP2"/>
    <dbReference type="GeneID" id="37114694"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17639">
        <property type="entry name" value="LC_FACS_euk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="108"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY74570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="703" mass="77436" checksum="9F98DB819CF89514" modified="2018-10-10" version="1">MPMSKKELQELRIQPRMYKKAPFSVEAPGYEPVEGETIPRRLPAAKDGLILRPAEDVATTYDVFRRSARVYGNAKAVGSRHLVKTHVENKKIKKVVDGVEKEVDKQWTYFEMSGYTYKSFVEYEKLALELGCGLRKLGLEKPDKIHLYGATSANWLAMSHGSASQSLTIVTAYDTLGEEGLKHSLVQTSSAAIFCDPVLIPSVANVLKDAKSIKHVIYNTDQEPKKEHLDRLKSENEGLNVLSMEDLRKLGEENPVDPVPPAPEDLCCIMYTSGSTGPPKGVSLTHANVIAATAGIHEIVGPYIGPSDALLTYLPQAHILEFMFENLCLFWGGTMGYGNPRTLSDTSMRNCKGDIREFKPTILVGVPAVWESVKKGVLNNLNKNNILVKSMFWGAMSAKNFLMTAGFPGADMGAWFLDSIVFRKLKEATGGRLRIMMNGGGPVSKDTQKFLSMAIAPMISGYGLTETSAMGALNDPMAWNPDALGEIPASIEVKLVDFPDAGYLTKNTPPQGEIYIRGGSVSSSYWQNEEETKEAYTDDGWFKTGDIGEFDKQGHLKIIDRKKNLVKTLNGEYIALEKLESIYRSSPVVGNICVYAAQDQDKPVAIIVPVEATLKKLANDNGIEGDTLETLVHNEKLTSIVLKQLQTAGKAGGLKGIEIINGVVLSDEEWTPQNGYMTAAQKLQRKKILNRFQKDIDRAYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVI2</accession>
    <name>A0A317VVI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SWIRM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_174998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464695.1">
        <property type="nucleotide sequence ID" value="XM_025605938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVI2"/>
    <dbReference type="STRING" id="1450535.A0A317VVI2"/>
    <dbReference type="GeneID" id="37108081"/>
    <dbReference type="OrthoDB" id="5598695at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="295"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="393" mass="44506" checksum="80117625EC095492" modified="2018-10-10" version="1">MTSFTAASLLSRSDKVNMSRLPSVSTLMSPPESKPLENFHPNTSSPYTMSQDPSYSHEVRLPPISSDRKRTQSEMDLPSPPVTPYTGNKKRRSNTSDHIEKDVVVVSSRDPVLFPRHESLTDIATDEPLFGSILPPTAEALVDQHINSHMARFENKINKPTRDEYLLALSCVPIVSAQFNRNPAAWAREERETLERQLIMMNRCRPRALEARLKKIAPAPTKRTIAAQPRVQRTPRVKRTPRTTPKQKILDTFDSPPMSAKPSRAIGTNRDDTDYNSIKDYSPSIETLGGNAKALKADWKGQVLDLSHDPDRHLLSSAELNLAATLRLSCATYLCSKRRIFDSRVKALNVGKEFRKTDAQQACKIDVNKASKLWTAYERVGWFDPEHFRQYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW81</accession>
    <name>A0A317VW81_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLAC8-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_603756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464537.1">
        <property type="nucleotide sequence ID" value="XM_025616445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW81"/>
    <dbReference type="STRING" id="1450535.A0A317VW81"/>
    <dbReference type="GeneID" id="37118588"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12891" checksum="129551F6DB89D6E2" modified="2018-10-10" version="1">MSDTQKGYRSWPSNLPTYHPTSSEEVRSVTYNKNWNYSLCDCCSPGSLCLTSCCIPGLTFGKMQARLRNPTLENYSSCNGECAIFTLRTFTWTQWLLQTIQRGKLRQKYGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW86</accession>
    <name>A0A317VW86_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_537796</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464903.1">
        <property type="nucleotide sequence ID" value="XM_025612354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW86"/>
    <dbReference type="STRING" id="1450535.A0A317VW86"/>
    <dbReference type="GeneID" id="37114497"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="84"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="405" mass="45738" checksum="6B9BFFE7EE1EE11B" modified="2018-10-10" version="1">MIASPHGIPWLMCNLLPIRREVARGIRHSASRLSYRPHQPWLYHSRFVHPVSRSSSSVSRPQQASAAQNMSSQKVPKPKAAVAVPRPSSSVVLISPKNEVLLLHRVKTSTSFASAHVFPGGNLSKQDGLCPPPEDLSRHDDGPWYRHAAIRELFEESGILLAKDRDSGKMLAVPEEQREAGRRAIHQYKITFTDWLKERNPAAVPDIEQLIPFTRWITPTNVPKRYTTQMYLYFLPLPLDIEKPILDEIPSDGQTEEIQIPTSDGGMEISEARFLPASEWIRMAHDGEVMLFPPQFLLLHLVAEFLNPGPSGTESVDELQKRRAELMQFIQSGQPSWTEKYICPKMLKVSSDGRTVLALDHPGPELKSSGRQGETDRVVLVKFKKGSVQDVEVRWKKDMFDSSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWK5</accession>
    <name>A0A317VWK5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_538155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XFP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464475.1">
        <property type="nucleotide sequence ID" value="XM_025612432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWK5"/>
    <dbReference type="STRING" id="1450535.A0A317VWK5"/>
    <dbReference type="GeneID" id="37114575"/>
    <dbReference type="OrthoDB" id="2532903at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02011">
        <property type="entry name" value="TPP_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01403">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023962">
        <property type="entry name" value="Phosphoketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005593">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018969">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019790">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018970">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019789">
        <property type="entry name" value="Xul5P/Fru6P_PKetolase_ThDP_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003617">
        <property type="entry name" value="PRK05261.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003619">
        <property type="entry name" value="PRK05261.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31273:SF0">
        <property type="entry name" value="PHOSPHOKETOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03894">
        <property type="entry name" value="XFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09363">
        <property type="entry name" value="XFP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09364">
        <property type="entry name" value="XFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017245">
        <property type="entry name" value="Phosphoketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60002">
        <property type="entry name" value="PHOSPHOKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS60003">
        <property type="entry name" value="PHOSPHOKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase N-terminal" evidence="6">
        <location>
            <begin position="25"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Xylulose 5-phosphate/Fructose 6-phosphate phosphoketolase C-terminal" evidence="5">
        <location>
            <begin position="605"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY77288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="834" mass="93940" checksum="91383FE7ADA58329" modified="2018-10-10" version="1">MPLELPDQSISAYGAARSTIQGQPLDPEEVRKMDSYFRASMYLCLGMLYLRDNVLLKRPLKVEDLKARLLGHWGSDAGQSFTWIHMNRLIKKYNLDVLFISGPGHGAPGILSQSYLEGVYSEVYPDKSQDERGMQRFFKQFSFPGGVGSHATPETPGSLHEGGELGYSISHAFGSVFDHPNLITLTMVGDGEAETGPLATSWHSTKYLNPCTDGAVLPVLHLNGYKINNPTLLARISHDELSSLMCGYGWTPYFVEGSDRETMHQAMAATLEHCILEIRNIQAQARQSKKPFRPRWPMIILRSPKGWTAPREVDGKLLEGFWRAHQIPITDVLTNPAHLQLLESWMKSYKPNELFTPDGRLIPELQTLAPAGNSRMSANPVGNGGLLRRPLDLPDFRAYALASIDPGVTIRGSMVNMSHYLRDVVVSNPTNFRVFGPDETESNKLSEIYKAGKKVWLADYFPEDSTNGGNLSPSGRVMEILSEHTCEGWLEGYVLSGRHGLLNSYEPFIHIIDSMVNQHCKWLEKCLEVEWRTRVASLNILLTATVWRQDHNGFTHQDPGFLDVVANKSPEVVRIYLPPDGNCLLSVMDHCLHSSNYVNVIVADKQDHLQYMDMPTAIAHCTKGLGIWDWASNDQGHEPDIVMAACGDVPTHEALAATSLLRHHLPSLKIRFVNVVDLFKLISPSHHPHGISDQQWKAIFTANRPIIFNFHSYPWLIHRMTYKRPGQGNLHVRGYREKGNIDTPFELAVRNGTDRYSLAVDAIDYVERLWNTAAGVRERLVNMRLLAVQKAYDDGVDPEYIRDWTWGYTPKKGERVQDELGMLGEEDLVKRSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXY4</accession>
    <name>A0A317VXY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_431261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464808.1">
        <property type="nucleotide sequence ID" value="XM_025607480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXY4"/>
    <dbReference type="STRING" id="1450535.A0A317VXY4"/>
    <dbReference type="GeneID" id="37109623"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000048">
        <property type="entry name" value="Sreptomyces cyclase/dehydrase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="5">
        <location>
            <begin position="54"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY78499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="215" mass="23750" checksum="6B7E9D27D581350A" modified="2018-10-10" version="1" fragment="single">RPTPHNHTHNHPTTTQHLLQTQTRPFLSSLLPGSSSSNNSSNSNKRHVTATRTLPYPPAPLFQIISSVESYSSFLPFLTASTVTHRDATTNLPTRAFLTVGYGPLSETFTSKVTCDEKNYIVEAKSGAEFGIATKEGQDGLGFPGADEGIFEYLSTRWELNEVKKEDGSGDGTEVKLDIRFEFRSQLHAMLMGKVEGEMAGVMIQAFERRIRSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZI8</accession>
    <name>A0A317VZI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">EstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_559175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464497.1">
        <property type="nucleotide sequence ID" value="XM_025614047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZI8"/>
    <dbReference type="STRING" id="1450535.A0A317VZI8"/>
    <dbReference type="GeneID" id="37116190"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016419722" evidence="3">
        <location>
            <begin position="17"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="25"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY77310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="848" mass="92819" checksum="524F2926BFE74FA6" modified="2018-10-10" version="1">MRNLFWLSFFCHAVFGHPRLANRDQSPVIDLSYARYQGNRLAAGVDEFLGMRYASSPVGDLRFRAPQDPPTNNTLQSATEYGPICIGVGQAETAGEVSEDCLFINVFKPSTATPQSKLPVWLFIQGGGYAENSNANYNGTQVIQNSGDGIVFVTLNYRVGALGFLASEKVRQNGDLNAGLLDQRKALHWVKKYIEQFGGDPDHIVIHGVSAGAGSVAYHLTAYGGKDEDLFIGAIVESSFWPTQRTVAEMEFQFDRIANETGCSDASDALQCLREQDIATFQKGNTASPFPGGSSSPLPDWYWLPVTDGSLVPEELYSAFDAGNFIKVPVMVGDDTNEGSNFAYNATSSADVSRFLKNNYPNLSTEQLEVINEAYPRGELLPRHAAYFGASSAAYGDATFTCPGNHVALSTAKYSPNAVWNYRVNIIDKSNIAGGIGVPHTFELPAIFGAGSTGTLSSGSSYLSYNAEIIPVTMHYFISFVQTLNPNTYRYSTAPEWKTWGNGERLRLQTNDTAMEVIPETSVQLCALWKELAETMEMPTRDLTTQQWINSLMEPGQILLWAFKSYITVNAESILNGQILAPLLYTSRLRDEAFGRFWVAFSTNRESDAPPPPPIQNSGEIQGSSDLIPPILAHASGIVLDVGPGTGSQMPLLRSPAIQTIYGAEPCHGLHAELRARAISEGLSDKYHILPCGVEAADLIPELQKQDLVSTNNADPTTVLKNLDNIGEGVFDTVICIRVLCSVPDMQRTIKDLYTLLRPGGKLLVVEHVVNPWRTRKGSVIARGFQVLYELMGWRLYMGNCCLNRDTAAALKMAAEKDGGWESFELERSFESTPMPYISGVLVRKGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W0D0</accession>
    <name>A0A317W0D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="11">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lipoate synthase</fullName>
            <shortName evidence="11">LS</shortName>
            <shortName evidence="11">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_537481</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465027.1">
        <property type="nucleotide sequence ID" value="XM_025612282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W0D0"/>
    <dbReference type="STRING" id="1450535.A0A317W0D0"/>
    <dbReference type="GeneID" id="37114425"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="146"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY79455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="413" mass="45383" checksum="20D7DD3B1AA68ACA" modified="2018-10-10" version="1">MAATSTYRLRLLCSSTRAIPQSSVLTPFTTRGYATTDSPSATTGAANPRRRTQFTDKLNAGPSFTDFVSGNKDNAPLDPEEAYALKTALVGPAGRKKQMTRLPPWLKTPIPDSKNYQRLKKDLRGLKLHTVCEEARCPNISDCWGGGDKAAATATIMLMGDTCTRGCSFCSVKTSRTPAALDPHEPENTAEAISRWGLGYVVLTSVDRDDLADGGANHFAETVRKIKHKAPTTLVECLTGDYRGDLDMVALVAKSGLDVYAHNVETVEALTPRVRDRRATFQQSIRVLEAAKKANPDVITKSSLMLGLGETEEQLEHALAQLRAVDVDVVTFGQYMRPTKRHMAVHEYVHPQWFEHWQRRALELGFLYCASGPLVRSSYKAGEAFIENVLKKRRAGLSEAVSDKNVAVDEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W275</accession>
    <name>A0A317W275_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoporin NUP37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_521572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464944.1">
        <property type="nucleotide sequence ID" value="XM_025610153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W275"/>
    <dbReference type="STRING" id="1450535.A0A317W275"/>
    <dbReference type="GeneID" id="37112296"/>
    <dbReference type="OrthoDB" id="5323870at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY79372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="71758" checksum="710891251565A091" modified="2018-10-10" version="1">MPSFPSRPLVRPRDDGLQLSYQLPHRVHTAKGYPLLAPNGSSIIVYGYETGLKVIWRGGRPFSNEKSSTPRVDRPRKPSNANDDAVMIIDSDDESTAETQHTQQDEEPDYQFEEDESEVDPIHPYEDVLRQIDIPLGSRVLELAVPRILPETARSSLDPFPPALTKDIVVAAVCADYSTRIVTLPLLPPHPTQSEIGIQTVSISGGVSHQETPRGVSATFTYQEFDQQDQDSSRTQGASRSSTGRWDLLVATHSAESSGLLIVHRIPITEEETASGAVYHLRDDEIETRRRYLPAPAVNVSFNPSGYPAPRHSTLLVAFHSGCLKIYSCFTVKPLKASRRSSAPQSDFETSETEGRWLISLYPGFEQSASGLARRKTIINAEWVLGGRAILVLTSDGEWGVWDIEGAGPGTIKGPLQRQSSVQGVTGGSLTAFSVSGRILSPLPGASRSEMSGPTFEQRPRFAPLTPSTKRLREDTLLKGGSTGTASPSLSGAISVYQTNSWKDALPDESILLQHGDQSAVIPSLLSLWRNTVKASGTFDASNRCRVSPIQDISLMGERLKGIGHLPAASRHTCGQSFDMLLTAEHRVVILAPRLTEPQPAPIPRAPLVETLTTETDQQMLQKGQLGVDGMDRLLSGMASTKRSLRIGSPIKRARIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2R5</accession>
    <name>A0A317W2R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_537509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465050.1">
        <property type="nucleotide sequence ID" value="XM_025612287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2R5"/>
    <dbReference type="STRING" id="1450535.A0A317W2R5"/>
    <dbReference type="GeneID" id="37114430"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="112"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="144"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY79478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="477" mass="54140" checksum="712A6F9AB91809E0" modified="2018-10-10" version="1">MSKKPADVASKERNEYIPSFISKKPFYIDDDSSANDYLEHQRLQKSTTDQSKWYDRGKRAGPAATKYRKGACENCGAMTHKTKECLSRPRKQGAKWTGKDIQADEVIQDVNMGWDAKRDRWNGYDPSEYQQVVEEYEELEKLKRLTKQDGEKGDSNGEADDDDAPEEEARYAEESDMGRQQSTATRNLRIREDTAKYLLNLDLDSAKYDPKTRRMVDMGAQDDQAAALVAEENFVRASGDAAEFEKAQRYAWESQERGLQKIHLQANPTAGEVMRKKEEAETVAKREAQRKALLEKYGGQEHLDPTPLRDTMVVENERFVEYDETGAIKGAPKKVAKSKYAEDIFSNNHTSVWGSWWHNFEWGYACCFSTVKNSYCTGEDGKRAFQEADQLLMLTDADADADADAERLSAELEETNDTHDDPQTPEQPKEASGINAKKRTLMEVQSGISEEEIESYKRSRLAADDPMAAFIGKDDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W407</accession>
    <name>A0A317W407_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_148975</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465337.1">
        <property type="nucleotide sequence ID" value="XM_025605790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W407"/>
    <dbReference type="STRING" id="1450535.A0A317W407"/>
    <dbReference type="GeneID" id="37107933"/>
    <dbReference type="OrthoDB" id="4461621at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="597" mass="67075" checksum="76739A3F73174CD3" modified="2018-10-10" version="1">MDIQSLLNEGSPSFAPNYGLPRFQNAEGANSLLLVSLTDLSETAEATLLNGFQHSPQANVKLSVWRPSRRVLARIAHQGLYHDSQENIYAVAVLAYRAGWTSLVVADGLTKRQLHGTLRVGENPQVSVVAVTIRPRSVTTSAEDNVRVNAQRTTVSDISNAELTLQPRPLPAYVKPDCYHDLGIVLHDPDRAPLSLDNAASLGREEWLDSARHVLATRTPLPAELVQQVMSYASSGTESPIALPSWVRNDEGRVMTIFLLFPTTAATRQTIQSTLEGATKDWMEKHGHAISSRTTPYKLISWEHHRAMSRRQLMKLWYEYAPRRGPGGLADAFFFLGKPVDNAADIQIGIFHKVWDGQANVTHKPLHVILEHPYPSTWRWEWELPPAPGLLSLDREENEVTELFHAFDQPFYSNPPPWLPTQSRLNYVAVFALTKTTPNQTDAIQAELCTWRVREQRFEEKVACFVPWDGEEDGTLDDIWRIVQELAIYHRGSPIFYPIFFVDRQSTADNTVLAVRPRPPGTPLPTDLPSRNLGGFSYGRVPGRDAHYIFDNVSMRRNYFSDLAPVNVFRRPDWPAALASQFPPEGGPVVLRLGGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4N0</accession>
    <name>A0A317W4N0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_495854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465644.1">
        <property type="nucleotide sequence ID" value="XM_025609274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4N0"/>
    <dbReference type="STRING" id="1450535.A0A317W4N0"/>
    <dbReference type="GeneID" id="37111417"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="39"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY81576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="467" mass="51295" checksum="D17FFBF8B223EA1A" modified="2018-10-10" version="1">MTAFEATKVYDVVVVGAGLSGLQAAHSIRAAGFSVCVLEATNRVGGKTLSVQSCENGVNDLGGAWINDTNQNEIFKLHQRYNLEGEIQYTRGDDILLLTDGVARKIPYGQTPTGLPQQLIEIFREESSHIDLHSPASSAEAERIDRQTFRDFCISRTGSQHAADFADAISAALLGVDSNELSALYMLYYFKCGCGVDNMLSDGKDGGQYLRTRQGTQTISLNMAKELDPEALFLDTPVTSIDQSRSDGICVVQTLGRPTFHCRRVIVSVPTTLYRSISFSPPLPEAKHTLSRDTVMGYYSKMIFVFSEPWWRNAGFTGILNCANGPITFTRDTSIPADDQWSITCFIVGSRGQTWSKLSKPDRQAQVWKAFCQCFAEFVESIPEPANVLEMEWSKQPFFLGAPCPVMRPGGMVSAGNSLAEPFGRVHFVGTETSLVWPGYMEGAVRSGQRGGAEVVKAFKDDHRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4W7</accession>
    <name>A0A317W4W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_576613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465734.1">
        <property type="nucleotide sequence ID" value="XM_025615146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4W7"/>
    <dbReference type="STRING" id="1450535.A0A317W4W7"/>
    <dbReference type="GeneID" id="37117289"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002918">
        <property type="entry name" value="Lipase_EstA/Esterase_EstB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015">
        <property type="entry name" value="FASTING INDUCED LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32015:SF1">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01674">
        <property type="entry name" value="Lipase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016323936" evidence="1">
        <location>
            <begin position="19"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="277" mass="29769" checksum="F35B466F256CF3E7" modified="2018-10-10" version="1">MHFSSLLLASAAILPAFGYSINDFSCTSTEHPNPVVLLHGLGATFYEDLNYLQYWLQAQGYCTYAKTYGAYDGFPFLGGLKSIADSAQEIAAYIREVKEGTGAEKIDLVGHSEGAFQTLYVPKFEDGISEMLDKLVAIAPPTRGTNFAGIYDLAYAFGNMSRAAVGDILDTVGCAACDDLGPDGAAVDRLNDGEPIVQSGNNLTVIASRFDELVTPTTTSFVHEDGVTNEWVQSTCPLDPVGHIGEAYDLNVWNLVKNALDSTPKREFICLLGSPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W560</accession>
    <name>A0A317W560_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_548439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465321.1">
        <property type="nucleotide sequence ID" value="XM_025613400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W560"/>
    <dbReference type="GeneID" id="37115543"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="198" mass="22362" checksum="5C4201BD47FA8A5C" modified="2018-10-10" version="1">MSGGLFTETRPFQDLYLGSPIRLPSLSYMETVGADHLATGYPQDRGGCNLTLRRNLMSITTCRLCSTENRTRVSSGKPIARASRSSVITANMRQMSHQVVEEALWQSDGNISLIRTNFVEVDILIIHCIWALESFVEQLSRPLNGHSTEGTGDLTTVVRIQPILTRITWHHRSFCKLLPAWRTEKRMNISIQEICWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5E1</accession>
    <name>A0A317W5E1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_587945</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464932.1">
        <property type="nucleotide sequence ID" value="XM_025615864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5E1"/>
    <dbReference type="GeneID" id="37118007"/>
    <dbReference type="OrthoDB" id="5413466at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="129"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="121"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="227"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY79360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="280" mass="30823" checksum="090AECEC367BB40B" modified="2018-10-10" version="1">MAPRRHNIGASRRRRRDDEGEDEGSLDGELEDDSLSEGSIISHPDDEDADGEGSDESEDEASVARETGNTHAPQHNGRTPAVNQKLGRRHSASPGKRHTVTAMSDTEAMLNGLRLSDEATEVAEIHFDDMKGGLGQPTGRTPSAPPAEPKQESLTERKRRDLEKYTKEKDENPAFVPTRGSFFLHDKRSTDSATNGYKSFAKSKSRPYGLIVDGNVRKNHVKPIASEKPWTHDLHDTVAGDDAPVSKLPALPPPISTYPQSQSLQPLGRRRPIDLSRTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5L1</accession>
    <name>A0A317W5L1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-binding TFAR19-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_537462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465012.1">
        <property type="nucleotide sequence ID" value="XM_025612275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5L1"/>
    <dbReference type="STRING" id="1450535.A0A317W5L1"/>
    <dbReference type="GeneID" id="37114418"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY79440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="132" mass="15053" checksum="6516AEE2D9A4889F" modified="2018-10-10" version="1">MADAELEEIRRARLAQLQQQGGARGGSDGNQEEQRRQAEAERRTTILNQILEPEAADRLGRIRLVKESRAADVENRLLVLAQSGQLRQKVSEDQLKQLLNAMAENQRKDEEEHKIVISRRGGWDDDDDLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6G7</accession>
    <name>A0A317W6G7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_547955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465757.1">
        <property type="nucleotide sequence ID" value="XM_025613363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6G7"/>
    <dbReference type="GeneID" id="37115506"/>
    <dbReference type="OrthoDB" id="4502466at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016372126" description="Apple domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="13556" checksum="453DD6A3935CF9A3" modified="2018-10-10" version="1">MKTFSTLFVTLSLLASPISAKGTNCWSGYASDTIGVFSGAPITFSMKLNGPVACGQKCDSVDKCAAWLYTESSGKCELYRRNALHISSNLGFAYGTCDGSSALLNNTTSSSAARVSSISVQASVTTVSNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W738</accession>
    <name>A0A317W738_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_587572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465430.1">
        <property type="nucleotide sequence ID" value="XM_025615834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W738"/>
    <dbReference type="STRING" id="1450535.A0A317W738"/>
    <dbReference type="GeneID" id="37117977"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF6">
        <property type="entry name" value="SPECIFIC TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06130)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="283"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY80828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="631" mass="70452" checksum="D8F141B4CEA17E4D" modified="2018-10-10" version="1">MELAWLAETPHSNHRRRVLRACPRCQIRKKRCRHVEPVPSPSRARVLNRQAKPTVSEVTHPSGETSASDTTVSPKTPRAQDESTRPERFLGAMNPESLIREKLDPATDVNPRRDRIGLWITSPVAERRQRGFQDGAIPSSPYPVELQTIADQLRQKHESAMTACMRLPLSTQQHLIPIYLSNVNHILPIVDQEAFHTAQSEGTVSPFLERAICLVAAKDKAAAPYLRLYDNVPVVSPAEFCTDIYRGLSVVINEGLEPDRITRIRVLALMALHCEDSEGTETASMHLYRAIHQAQAVGLHLIRPGNTEHPLSGLFWCLWTLDKTHACMGGRAVLLADQDISIRKPAAIRNTLSRPRTAFEVWFAISDLLSDVIYLYRPGADRNSRAARWERGFPSFDEIIGSGVEEDVDIGTLGFLELFYHAVGILFARNHSPEHIESPSPFHIRQDHAAIRIQSIAAKECIHDLPPLPIVPYALSLSMGVSYQQYRSSNLITHLSRSKADLEARCSLLEILSPYWYSADKMAQLGRKAVNQIHERPDNQPGLTMTGNTTQPPVGMSGHGNRITWVNSTSIDSTREHSANAESSHNELQDLALDGFADIDVIFGDFLDLSLPNGYWDPAFPMTALDTNGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBB5</accession>
    <name>A0A317WBB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_468964</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466254.1">
        <property type="nucleotide sequence ID" value="XM_025608281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBB5"/>
    <dbReference type="GeneID" id="37110424"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="576"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY83786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="777" mass="85732" checksum="91132D1AEBAD2D55" modified="2018-10-10" version="1">MSPSLTDSPIEGDGILVSNQNAVDEKSAVTVLANKDETKVSGDELSGEDDRNSEDVIIVNGADAALHLLPLRDDFDNALTFRSILLASGLACFQAVMNQIYMFKPTAVNIQGTFIVLIAYFCGNAWAKFLPRGDKFEARWRAKGGEGKLPWSITLIKLLNPGPWSLKEHSICAITATSASNASASSQVFAAQNLFYNMPFSAVTVILSTISIGLFGYGLCGIMRPIAVWHVESVYWYTLPTVKTLQGLHWQEVKNSKPLRYFWYAFTGMSLYEIIPAYVFPWLNSVSIPCLAAQKATGLTGQTLTYIFGGATTNEGMGLFSLSFDWQYITSFQTSLPLKLQLHQAIGIGVCFIVMSGIYWGNGWNAKSLPFMSTELLMANGTSYPLTSVFPNGVLDKSALAEYGVPRLTGTFAYAMLMANAAIGALIMHCILFWGNDIMEAYRSAKQGRYDDRHHQHMAKHYKEAPWWWYIAVLVISFIFGLVVVLKENISLPAWAYIVSLVIGIIIAPFSTILFARYGNGIATNNLSKMLAGLMLPGRPVGNMYFAAWSHNVISNAVNLSNDLKMGEYLKIPPRVMFLTQIYGTILGGFINYAIMISIVSGNKALLANGNGDSSWSGATMQSYNTNAASWALASYLYKAGTPYAMVPVGLAIGAGAVIVHRLFYQFIPKIGRFDISEINMPQFIQYAGYIPYNQSQTCILFSWIIAGFYVQYYLRNWHPRIFKDYSYLITGAFDGASLTVIFILSFAVFGAAGSAHNMPNWWGNNANGNYDWCPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WC17</accession>
    <name>A0A317WC17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclohexanone monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_599432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466371.1">
        <property type="nucleotide sequence ID" value="XM_025616321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WC17"/>
    <dbReference type="STRING" id="1450535.A0A317WC17"/>
    <dbReference type="GeneID" id="37118464"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF8">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="650" mass="73926" checksum="AD2EC4797F4AFF62" modified="2018-10-10" version="1">MGNILSSCARDQAKSRGSDNTTPPPPSWKALTPSTPATSQSLPRPLSNEKKPLEETLADIPIPIPDRYHSEPHAVRIIHVGAGAAGLFAAYKAERMLTNYELVCYEKNATIGGTWLENRYPGCACDVPSHIYNYSFDPNPNWSSFFSPSEEIQAYFVRFYEKHQLQKYMRFNTTVRGIVWHDAKGQWEVELERKDGSRFTDWCHVLINGSGVVNKWKYPDIPNLEQYRGTLVHTANWDPDIQWKGKSVAVIGSGASAVQVLPQLVDDAASLVCFARNPTWIIPNVLNVDPVHPAGMPAAAYGKHHYVAEELQLFRDNPQALLAYRKQLESSIIHLFPGFLRGSPLNEMLKQQMRQVVEAQLGGEGNRGLRDAFLPTWSPGCRRITPSDTFLQCFQKPHVTLDRNHLASFTEQGLRTANGTEYKFDIIVCATGFDIQFTPHFPVIGRNNTPMQHEWRETPNLYLSITGPKFPNYFVINGPRGNWNQGSTLPSHETQISYALQCVHKIQTEHLHSLEVRQHPTTALNRWIDAWHAQKSIWAEPCRSWYKRNTADGRVYVWCGSMPHLLKSLKRPRWEDYRIRYWEEEEEEETGQGKEGNMWAFLGNGTTVLEEGFRRGLEVDVAPYIRAEDSEWDVEMLLPPVVEEVEGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCL0</accession>
    <name>A0A317WCL0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_519650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465882.1">
        <property type="nucleotide sequence ID" value="XM_025610080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WCL0"/>
    <dbReference type="STRING" id="1450535.A0A317WCL0"/>
    <dbReference type="GeneID" id="37112223"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="388" mass="43737" checksum="0A0AFA1D7A0155ED" modified="2018-10-10" version="1">MSKSTKYLLVSLPTSITPSHHRDDALDAISATVSSENGSVAPFPIPEFKIGTLDALVQQADELAKLETACQGVVVKVGDALKNILEGDEAQIDKMKTVNDKPVDQYLRTFSWNKVKYRADKPLAELIDSLQKEAASIDNDIRSKYTQYNQVKNTLATLQRKQTGNLSTKSLASVVDPRTIVQDSEYIETHLVAVPAQQVKEFLKLYETVAPMVVPRSATLVASDSEFALYAVTTFKKHSLEFVHKCRENKWIPRDFKYVEGGKEEERKEVERVGGDERKLWGETLRLGRTAWSEAVMVWIHVYVLRVFVETVLRYGLPLDFVCTLIRAPGSKQADKAKHNLDDKYSYLAGNAFGRDKKGRVKRDEPGELHGEGGGEYTAYVYYEFEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDH6</accession>
    <name>A0A317WDH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_599582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465893.1">
        <property type="nucleotide sequence ID" value="XM_025616327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDH6"/>
    <dbReference type="STRING" id="1450535.A0A317WDH6"/>
    <dbReference type="GeneID" id="37118470"/>
    <dbReference type="OrthoDB" id="3503419at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33633" checksum="A4FFEA02F939A2DA" modified="2018-10-10" version="1">MYESLSPYVSDRTPTLVSSRIWPRIIVRGHQDVLICGANNEDTSFDRQRTTAKMIDSETLEICCFPGKDHVHHYALLIAYHLALNDIQQSSVIECNLPTKVDTMGVIEQSNLRSMGKVDTVVLGCVEDLVVPTDEQDQWETGTSTANRLFAWKLFRRREGGVVSFLTCLFRPWGDILDTVVRALRHLNDVSCVLYTGKAGSLRPDDIPNDMLVTGDISYVAGKRVTWDNVLEPAISAARTSKVCRGINVTVMSPLVETDAWLNEWNGRADWVDCEVGHAAEACHVSQMRFGYLNLISDNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE49</accession>
    <name>A0A317WE49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase</fullName>
            <ecNumber evidence="13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_536256</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="13"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466588.1">
        <property type="nucleotide sequence ID" value="XM_025611970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE49"/>
    <dbReference type="STRING" id="1450535.A0A317WE49"/>
    <dbReference type="GeneID" id="37114113"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="19"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY84663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="499" mass="57161" checksum="9F33D62DFC8FE217" modified="2018-10-10" version="1">MGKDDQSKTYRYNETPIYTTSNGCPVMDPQAAQRIGKNGPLLLQDFHLIDLLAHFDRERIPERVVHAKGSGAFGEFEVTDDISDITVIDMLKGIGKKTKLFTRFSTVGGEKGSADSARDPRGFAIKFYTEEGNWDWVFNNTPVFFLRDPAKFPIFIHTQKRNPQTNLKDATMFWDYLSTHQEAVHQIMHLFSDRGTPYSYRHMNGYSGHTYKWIKPDGTFNYVQIHLKTDQGNKTFNNEEATRLAADNPDWHTQDLFNAIARGENPSWTCYVQVLSPEQAEKFRWNVFDLTKVWPQSEVPLRRFGKLTLNKNPENYFAEVEQAAFSPSHMVPGVEPSADPVLQSRLFSYPDTHRHRLSGNYEQIPVNCPLRSFNPTHRDGYMNVHGNYGANPNYPSTFRPIRYQPVKASQEHEKWSGSVVVEQLPVTDDDYVQANGLWQVLGRQHGQQNNFVHNVSSHLSAAHERVRKATYGMFRRVNADLGARIEKATEAKANNTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEA5</accession>
    <name>A0A317WEA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_536306</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466638.1">
        <property type="nucleotide sequence ID" value="XM_025611985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEA5"/>
    <dbReference type="STRING" id="1450535.A0A317WEA5"/>
    <dbReference type="GeneID" id="37114128"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.770:FF:000004">
        <property type="entry name" value="Phosphatidylglycerol/phosphatidylinositol transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00737">
        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016275809" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="46"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY84713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="175" mass="19360" checksum="21C9919B426A272D" modified="2018-10-10" version="1">MKLLSTAATFLLCVAPFSATARSLDFFGSQTPIKAEGKHVEGENPLEYCSDPSSYILQIEKVDLSPNPPLPGQTLTIEAKGTFNEKIEKGAYVLLEVKYGLITLVRQRADLCDQIVNVDLECPLEKGEMALTKQVDLPSQIPPGRYTVHADVYTADDRRITCLDAPNVVFKRNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEW3</accession>
    <name>A0A317WEW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">CP2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_557373</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466480.1">
        <property type="nucleotide sequence ID" value="XM_025613925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEW3"/>
    <dbReference type="STRING" id="1450535.A0A317WEW3"/>
    <dbReference type="GeneID" id="37116068"/>
    <dbReference type="OrthoDB" id="7680836at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007604">
        <property type="entry name" value="CP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057520">
        <property type="entry name" value="GRHL1/CP2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040167">
        <property type="entry name" value="TF_CP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037:SF20">
        <property type="entry name" value="PROTEIN GRAINYHEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11037">
        <property type="entry name" value="TRANSCRIPTION FACTOR CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04516">
        <property type="entry name" value="CP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25416">
        <property type="entry name" value="GRHL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51968">
        <property type="entry name" value="GRH_CP2_DB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Grh/CP2 DB" evidence="8">
        <location>
            <begin position="224"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="423"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY84555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="757" mass="83864" checksum="529233D98FC0A357" modified="2018-10-10" version="1">MFRNRKNSQKPDDELIQKFQRTFSDVVPQAPPPHRNATRFGQMPVGPITPARLSMNHDLKLNDPTPRATEDMRFAPPYVDPNAVSYVNALQPPGYYTPNSGGLGAMYHSQAGDLHTPGMGLSMITPLSLPQQISAATINAGTAAMGLDHFDQQYIPPHFQNPQPFAQQPAFAPSAFVQGDTGYDAMDDSVDELSLNDMDMQGHPSQFVTSTMQDDQASIQNPGETFRYHVTLRAPTAMINHQAEIPVTYLNKGQAYSVSVIDSTPPPMTVQPLKYRTYIRVSFQEEEQRAKPASCWQLWKEGRGSNEAHQRGGKLQAVEYVDPIQGGIEDTKNRQIQLESSSFDGFCVTWTLNPSTGASECSIPVRFNFLSTDFSHSKGVKGIPVRLCAKTEMVLPDDASPTSGKDSEVCYCKVKLFRDHGAERKLSNDVAHVKKTIEKLRQQIAQAEMGTGNYGKRKRSGGSIALKGTDPRPTKITKHKRTWSMGSQDGPGKLSLEDDLHAKLALMQDMFTSTRPVSILGLRGEEQDDPDLFPVSLPGSREFIKQENNRGSRFSIDGTSLHAVSPTSSSISINSPCHPTNVQSNLFYDSAYHGSMSTSRDNSRSCSEVLGDKGALKHPVKVQKVASTDGNAPMGYIEAVDIDPTYRPPVDRPVKPIACFYVRFPRNDQRSDDYYRAVYLTERTVRDLMEKISVKQRIDPQRIVRVLHVKQNGLKIMVDDDVVRELPDGQDMVVEISEASSFENAAATSAVEVKLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFH8</accession>
    <name>A0A317WFH8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CDC73-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_547275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466620.1">
        <property type="nucleotide sequence ID" value="XM_025613324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFH8"/>
    <dbReference type="STRING" id="1450535.A0A317WFH8"/>
    <dbReference type="GeneID" id="37115467"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000003">
        <property type="entry name" value="Pol II transcription elongation factor subunit Cdc73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="7">
        <location>
            <begin position="281"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="235"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY84695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="473" mass="51303" checksum="13DEA69AC8B114CD" modified="2018-10-10" version="1">MATDPSLQDPLLSLRRAIAAGTLPTPTTSSDLSDQNATDDLAKATHLYFQNPLPQNISLNTPTRFVSSSSDSAVDLRSIFFAWQKKDVAIPEYIASAQELNESLKQKERREGDEEEKVQNLVFVERLDLLTWLEGASDESEYIKPLEGAAAAAAAASAAAQAQASANIASGAAGGVSAVPSGAPGGPAQTQQGKAAKVIDPRLQEIYNGERKMGDRNSVLRGIKPTDFSHVRKTAESILGRNRSRPGQYPAGVKAGSKPQSMVVPSPSAGLSQSRKGSSKTQDPIILLSPSASSLIRMSNVRSFLQDGVFIPPDHSSLSMSNSNILYISRPLRMNSDPSGSSLRPGGGNSSQITSRKPTRFILVDSTANFRPDYWQRLVAVFTTGQTWQFKSYKWSSPPELFKHATGVHVGWRGDDVPREVRSWGRGVQSFGVERWDEKGGAHGAGRWRDREVVEGIWTAIEEGMRQRGWGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WG45</accession>
    <name>A0A317WG45_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_468094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466596.1">
        <property type="nucleotide sequence ID" value="XM_025608234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WG45"/>
    <dbReference type="STRING" id="1450535.A0A317WG45"/>
    <dbReference type="GeneID" id="37110377"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF2">
        <property type="entry name" value="DEHYDROGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="18"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY84671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="350" mass="37173" checksum="6E0F8FCEC1F50938" modified="2018-10-10" version="1">MAVPQTQIAAVLPPSGATTTSKLQIVHDRPVPSPTEGEVLVKLEYSGLCHSDVHSVRGETPMLTDIAGHEGVGKVVKVGSGLDEQAWMGRRVGIRWLYSSCLECEICAINNTACPYQKNAGANVPGTFQQYVVSPAIHATIIPPELAPDVAAPLLCAGIAMYSSIMKTKTRPGDWIVLPGAGGGLGHMGVQIASKKGLKVIAIDRYEEKKLCLSLGATSFLDYKTDDVEREVKALTSGLGAQAVICTANSEPAYIQSMKMLRSLGVLVCVGIPSVPFKLPATPFDMIVKGLTIVGNSAGTAKEMGELMEMAVAGDVKAHIECFDFDCIDDVLQRLGRSEIEGRAVVRIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WI24</accession>
    <name>A0A317WI24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_598787</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466633.1">
        <property type="nucleotide sequence ID" value="XM_025616288.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WI24"/>
    <dbReference type="GeneID" id="37118431"/>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000073">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016355154" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="2412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1073"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1987"/>
            <end position="2007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2019"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2045"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2076"/>
            <end position="2099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2111"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2157"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2202"/>
            <end position="2219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2239"/>
            <end position="2261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2281"/>
            <end position="2299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2311"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2338"/>
            <end position="2360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2384"/>
            <end position="2404"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="66"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1695"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1808"/>
            <end position="1843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1928"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1733"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1935"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1949"/>
            <end position="1959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY84708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2412" mass="270460" checksum="0991EC3BA45A4B6E" modified="2018-10-10" version="1">MKWGTAGSLLALFVSTTTGWPYEASLVDYNLNVNKTATSPFDYSPPKWPGHNYTASPKNWRFPFYTIMLDRWVNGDPANDNINGTLFEHDLNSNQMRHGGDAVGLVDTLDYLQGMGIKGIYLAGTVLMNQPWGADGYSILDTTLLDQHYGTIQTWRNTIDEIHKRGMYVIFDNTVATMGDLIGFEGYLNVTTPFSVKEYKTLWKSNREYVDFRPGNSYNETCDYPRFWNETGYPVDEYVNQELVGCYDSDFDQYGDIEAFGVFPDWQRELTKFASVQDRLREWHPSVRDRIKLHSCNIIKALDIDGFRYDKATQATVDALADISNTYRECARSVGKENFFIPGEITGGNNFGSVFLGRGRQPNQYPASAMDAIKMTNKSDQKYFLREPELEAIDGAAFHYSVYRTLTRFLGMSGNLAAGYDTPLDWVDAWNVMMQTNDLINANTGKFDPRHMYGVTNQDVFRWPAIEWGVERNLLGIFITTLQMPGIPLLLWGEEQGSYIIDATADNYVYGRQAMSPATAWKTHGCSAIDDTQYYDWPITKGRDGCHDMSVTYDHRDPSHPIRNIIKHMYQMRQNHPVLNDGYSLQTLSKQTRNILYPGSYGVETETGMWSILRDRISGVQDLGSDEDNQSIWLIYQNDNKTVEYMFDCKSNASALIAPFPTGTTVKNLFYPFDEHTLKDSPKRLHLNGSKELNGCLDSMTLKAFDYRAYIPKARFVSPLPMITKFTPGHDVPLLSTVAIDEAEDIDVSIEFSTKMDCDSVTQSITLTSQTEAGRTPSIDKGTVNCKSLTVSNDTQYIGQLPSAWAWSAKLTGVYNGIHKLTVKNATDSDKKDSTESVDHFLFRVGQGDNPLVFTTSNYSTSILHQYDNGTLYIQHKAAGANKYRYSTNWGTTFSGWLNYTGGNDTIEELPWSGTEKQKWKGKHVRVEYWSQLTGSSDYVQEGDYDWNGPKRRFPHFFFNGPYNQYGFDAGLDNVVKQDSEGFWNFKVVAEYPAQGQFNVWGMDPDGQPDESFVFGDVDGDGVLDRMPPSSLSKLSVNITKIPPYPYLVWNVHLDDGNMRLNLEPTGSRITQLVVYILLWLVPIVTGAACVYAFMKSFYQVKFNQVGVVEKKSLLSAIFGKRSRDGQSTNALGRLANRSGFLQSTSAFGAGGSRRRTTLIATMEYDIEDWGIKIKIGGLGVMAQLMGKHLGQQNLIWVVPCVGGVDYPVDQPADSMYVTVFGKEYPVQVQYHVVKNITYVLLDAPVFRQQSKAEPYPARMDDLDSAIYYSAWNQCIAEAIRRFQIDLYHINDYHGSIAPLYLLPKTIPVCLSLHNAEFQGLWPMRTQKERDEVCSVFNLDTDIARRYVQFGEVFNMLHAGASYLRVHQQGFGAVGVSRKYGKRTYARYPIFWGLKKVGNLPNPDPSDTGEWNKELPKESEILVDPLYEASRAELKRQAQAWAGLEQNPNADLLVFVGRWSMQKGVDLIADVMPAVLEARPNVQLICVGPVIDLYGKFAALKLDRMMKVYPGRVFSRPEFTALPPYIFSGAEFALIPSRDEPFGLVAVEFGRKGALGIGARVGGLGQMPGWWYNIESTTTSHLLHQFKLAIGSALNSKPQVRAKMRARSAKQRFPVAQWVEDLEILQSTAMRIHSKGLVKSNNQPLSSSGYNTPSGLTTPTIASGHITPSGVQTPPIAHSREGSYSNVRLSTLGPQQRNTIVYSRPPTPGANEQPKSGLGRQLSLGVRAGPGHLVRRGRRRLRRSMGHEESANASNTEESSDDDIRPSSYYGEDEYTITPEQAEAGRRMEAAQQLDTQRQPPARDFFSVRHSSQSSLPPRPALSPVSPGSPEPEEAHVTPGNRLSSASVLSVDSIIGEKKDYKLQKVDPFFTDSTGEYYRAFEKRLENLNGHNSESQLCIEEYLVKSEKKWFGKFRDARLGRNQSPASSIFHGKLDNSSPMGSDSNVDIGSRESGSEGHREKDEFLLGNDYVPPTGLRKWMQIRIGDWPVYSLFLGLGQIIAANSYQITLLTGEVGETATKLYGIATVYLVASIVWWFFFRFFKSVFVLSLPWLLYGLSFVIIGVAHFEGNTFARGWIQNVGAGVYAAASASGSLFFALNFGDEGGAPVKQWVFRACLIQGSQQAYVIGLWYWGTSISQAVQNGNTNVQGYITETWKMTAICLPIAAFLWVIGLLIFFGLPSYYHQSPGKVPSFYKSVFRRKIILWNFVVVILQNFFLSAPYGRNWSFLWNSAHAKAWEVGILCIVFFGFVWAGWLGLFGYLSKRHSWILPVFACGLGAPRWAQIWWGVSGIGLFLPWAGGYTSGALVSRSLWLWLGVLDSLQGVGFGMILLQTLTRMHICFTLLASQVLGSIATICARAFGPNKIGPGPVSPDISVGLDSLANAWFWLALFFQLLICAGFLMFFRKEQLTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMR6</accession>
    <name>A0A317WMR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NTF2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_78996</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466938.1">
        <property type="nucleotide sequence ID" value="XM_025617664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMR6"/>
    <dbReference type="STRING" id="1450535.A0A317WMR6"/>
    <dbReference type="GeneID" id="37119807"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990861">
        <property type="term" value="C:Ubp3-Bre5 deubiquitination complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="61"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="407"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="476"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="515"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY86347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="56572" checksum="DB27A06C176D3089" modified="2018-10-10" version="1">MADTTQAPINGGYPTQHAYPDSFNHAPANVNSAASFQPAPSSTTSNAPSNDQKNGISKDEVGWYFVEQYYTNMSRSPEKLHLFYSRRSQLVFGTEAESVQVAVGQKAINDKIKQLDFQDCKVRVLNVDSQASFDNILISVIGEISNRSEPSRKFVQTFVLAEQPNGYYVLNDIFRYLVDEEEEIEHEEAAPAAPAAPAAPAEEPAAEVPAQPEVESVPEPEETQVDSEPAAAKVDDKLEETEEDVEEEPAKESAPQTNGAAVQETSVEAAPEAVAPVETEAPKVEKPATPEPTPAPEQKEAPAPAKESAPAKFVPKTWANIASKSGAAAPVVPAIPVAPVKAAPAASSSPSTATSAAALAPTPAPAPAPEAAPSQPPSTDGSGWQTAGHDHKKTQSRAGEEQNVLGYIKNVTEKVDAALLKQTLSRFGKLKHFDVSRQKNCAFVEFGDAAGYAAAVAANPHQIGTEQIIVEERRPRSNAFGGNGNYGAGRGGAGRGRGDRAGSQGRGGFQRDGRGGFAPRGRGGNVNTKARNQAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN85</accession>
    <name>A0A317WN85_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Translation machinery-associated protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_585278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467576.1">
        <property type="nucleotide sequence ID" value="XM_025615683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN85"/>
    <dbReference type="STRING" id="1450535.A0A317WN85"/>
    <dbReference type="GeneID" id="37117826"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015157">
        <property type="entry name" value="TMA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28632">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09072">
        <property type="entry name" value="TMA7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="68" mass="7199" checksum="EF712458BE1E4935" modified="2018-10-10" version="1">MGGASREGGKVKPLKAAKKDKKELDDDDLAHQAKLRADAKAKKELMEKAKGKGPLNTGAQGIKKSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNG1</accession>
    <name>A0A317WNG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_535020</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467792.1">
        <property type="nucleotide sequence ID" value="XM_025611677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNG1"/>
    <dbReference type="STRING" id="1450535.A0A317WNG1"/>
    <dbReference type="GeneID" id="37113820"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.30:FF:000004">
        <property type="entry name" value="tRNA (guanine(9)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 18" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="17">
        <location>
            <begin position="121"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="339"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY88009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="403" mass="45458" checksum="7C9EA48ACFDB89E3" modified="2018-10-10" version="1">MEEEGRPRKLPKLDHDETQNPEPRMTGALETNTGDNEQRVESGDGANGSEPTQQTEDGAPKISKREMKRMRRREQWEGQRDQRKAKRKERGIARKEKRRAALEQAREDGTLEELKKTYERTHKRFRRSTLLPLTLVIDCGYDELMLEKERISLGSQITRSYSDNSRSAYRSHLVFSSFNKQLKERFDTKLNKHYLNWKGVRIVPQDFAQVAEMAKEWMVVPAGGRFEGVFADKTDSTPEDGEVVYLSSDSPNTLAELKPFSTYIIGGLVDKNRHKGICYKHAVEKGIKTAKLPIGDYIQMASRQVLATNHVVEIMLKWLELGDWGKAFLAVIPQRKGGTLKESAGAAGEGSQVEDAEEEEEDAEEDEEQAMAQAQQVTDEGIEEAQQATEEAPAEAGDAGDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPE5</accession>
    <name>A0A317WPE5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_596340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467340.1">
        <property type="nucleotide sequence ID" value="XM_025616252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPE5"/>
    <dbReference type="STRING" id="1450535.A0A317WPE5"/>
    <dbReference type="GeneID" id="37118395"/>
    <dbReference type="OrthoDB" id="2534600at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF2">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY87132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="586" mass="65253" checksum="BBFD75DD9FABDD17" modified="2018-10-10" version="1">MPSPRPSKRQRIGRACDQCRHRKSRCDGEQPVCSICRSTGRACTYQIASRHRGLQSGYVRSLEVALGLVLDRFPGNEGSLRRILRDTRQHTLEVASELADRGRHSKLARDVGRLLNGETDKGQSPSDDDPESEVMCAVDENGGERQATQPPKESASPSDCLDCPFPENSDRLLQFYFTHIHSWFPIVERREVLRSLHTPPQASKSARDVSCRLVLWAIVAYSSAMDDTLEKSHGPMQIAHAIRLQVLMAPDEAEIGHLQSLLIITLLHLGWGDLRLAWLLAGEVTRMLMMLPESSRTVRYQHTLHGCILLDNLISGILDKAPGISLDDVSHCEPVSEDDVDEWELWTGEKVAAKGPLRSLSTFNLINELMKRPYGGDSASPSLLTLHLTADFVVFCLALHKADSTVGQLALHSLHTTVDMLDTYVRLTGTAKSSPLLRCFIFQAYRCLRIVPMSSPTGPLHGRLVHLIHQLKLTNSETNAPEALFTWLPGRRLSGPMTVYNEYHLNLGNPDHQMATPELSITPVIPMPGQLDQTEDFDALFEEMVSSSPQTRGEPTFAENLGFYAGNLDADFLEQLQHIPDTSDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPN8</accession>
    <name>A0A317WPN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_491966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467778.1">
        <property type="nucleotide sequence ID" value="XM_025609170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPN8"/>
    <dbReference type="STRING" id="1450535.A0A317WPN8"/>
    <dbReference type="GeneID" id="37111313"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="73567" checksum="2CFDBD8BACEEBD64" modified="2018-10-10" version="1">MTEVLGKGNPHIFVQPHDEPDAFSFPSRSNRGSSGIPSGASAAHSEEDTVFNSRSEGCGDVVQPYAIEEPEDDPMETAGKSAGKPVIHLYLGNSSDIWQGELVDSMEGLYCDPDCANHQSTINHKRGKKRRPSATAAGSFRLFRQLSSGTTPDNQYDWSIDATKRRRRKGRCAREQFTAFPGTFWQHEANETESSDSFISRTSTRQAAQKAKEAIAAAPDVKSRGAAGTKRKESTDKGPAPKRGKKTEDKVTPKTQPPATDEQKATDEGAEVPEKNDVKSPEEPKKSVEEEPDRKTEEKPAGKPDEKSEQKDEEQSGEKPDETEKLEEKSQQSEVKNEEKPEKTEEMPDKKPEEKPEENAAPAPTDGTKAGVKTSQEREEKVASNVLEKGIIYFFYRPRVNVSDPHSINDVARSFLVLRPMPIGATLDQQQGSVEPGAKCRLMMLPKKKFPTSGKERDMGFVEKTGQSMKSLQENFIAGNTYETSTRGEQSVPEARPYAEGVYAITSTKGSSHLAYVLTIPETIGSIQEDFGLHSRGSWVIQLKNPKHPGPSYAHINKEPEYPESVREKFGDYRWVPVQPEFIDYPNAQFLMIGAATDDLGKAATAEDGDKQANEEQPDDELEKLEQKNEERIEGLRGNDTIYEDLGLDAKKYPKVPTTWNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQQ2</accession>
    <name>A0A317WQQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidase FUB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Fusaric acid biosynthesis protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_534732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468196.1">
        <property type="nucleotide sequence ID" value="XM_025611613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQQ2"/>
    <dbReference type="STRING" id="1450535.A0A317WQQ2"/>
    <dbReference type="GeneID" id="37113756"/>
    <dbReference type="OrthoDB" id="6475849at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000056">
        <property type="entry name" value="hydroxyacid oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF149">
        <property type="entry name" value="2-HYDROXYACID OXIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="304"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="327"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00083297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY88834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="385" mass="42212" checksum="B3F381BEF212297D" modified="2018-10-10" version="1">MSPPPDLMLSIEDIKIAGSKKLPKMAREFYNSGSTAQITVHENTTAYNKYRLRPRVLVDVSNLSLTHTLFNQTFDFPLGISPTGLQAMAHPDGELATSRAAAKRNIPMAVSSFATYPVEEIVDAAKLTPTSTPQPTIPTEKRGGPYAIQLYTLRSRPLQQSILTRAEKAGCRAIFLTADSPVLGVRYNETRNNFRTPPGLSWPMLNVSSEALQSQSHDSGFTATNSDSHSWAREIPWLRSVTNMEIWIKGVLTAEDVLLAREWGCDGVVVSNHGGRQLDGVVATVDALPECVRAAEGKIRVHVDGGVRSGVDVFKALALGAEWVWVGRPVVWGLAYDGEKGVSRVLDILYEEFKRCMQLTGFRTLKDITPAALARIRPDGTVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSL2</accession>
    <name>A0A317WSL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_36117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468355.1">
        <property type="nucleotide sequence ID" value="XM_025607168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSL2"/>
    <dbReference type="GeneID" id="37109311"/>
    <dbReference type="OrthoDB" id="5089392at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="175" mass="19291" checksum="08070086FF6BB37B" modified="2018-10-10" version="1">MDNYNQTSTQPTFHYHPHTLKRALSQSTTSSTSSTTTTPSSPNTHGSKTKPRKASRLSSVKDFLHSRSNSPTPSDCSSPVPTFDIPRSIPSNSDHRSTSPTAMSHRVSSDGDSHSASHKRSTSSAYARRSGDDYRRYSGTVNHYGRHSNDWLFGGFSLRDTVRGGVDRLRHHSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSQ1</accession>
    <name>A0A317WSQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_556742</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467448.1">
        <property type="nucleotide sequence ID" value="XM_025613887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSQ1"/>
    <dbReference type="STRING" id="1450535.A0A317WSQ1"/>
    <dbReference type="GeneID" id="37116030"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000004">
        <property type="entry name" value="Polyubiquitin Ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY87240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="308" mass="34620" checksum="95EEE306BBBF617C" modified="2018-10-10" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKNKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKSKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGNMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT55</accession>
    <name>A0A317WT55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_465142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467891.1">
        <property type="nucleotide sequence ID" value="XM_025608100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT55"/>
    <dbReference type="STRING" id="1450535.A0A317WT55"/>
    <dbReference type="GeneID" id="37110243"/>
    <dbReference type="OrthoDB" id="2533084at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="441" mass="48925" checksum="7A89345794F60FFE" modified="2018-10-10" version="1">MKDQAKTWDKALIEITYTISASIAGIAYGPLLINPLAQAFGRSAVIFWCLLFAMACAIWSACMTGKGDYERFVASRLFDGIFGSIPSIVGVGGVYDMFFLHERGKAYAIFHVSFLFGTVAGPTFGGFIVDHTRWPWVFWWIVIAQGLVLILAFLFLEDTSYPRDGHTPVAKPRTFWANRMATLLPHKTGISRAELGRIACLPLRIGLSPVGLLIGVFQLASFGWFVATHSLLTVWLEKPVTIGGWGFTPQRNALFIFALWVGLLTAELWGYLCNDRIALWVCRAWGKGVWKPECRLHALWIPSLIILPIGLGIVGSALQYHLHYMVLALGAYLITFASMSSVPVAVTYMIECVASQPTEVGVFMGAYRLTLGLAIPFFIDQWVARVGFGWVYGMMAFFSIFAFGFVIALMLFGDRLRQRTLGRLAASEIGAKMIYASEEDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTI1</accession>
    <name>A0A317WTI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_490280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468316.1">
        <property type="nucleotide sequence ID" value="XM_025609117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTI1"/>
    <dbReference type="STRING" id="1450535.A0A317WTI1"/>
    <dbReference type="GeneID" id="37111260"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="446"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="3">
        <location>
            <begin position="721"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="930"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="932"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="976"/>
            <end position="992"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY89405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1028" mass="120519" checksum="80E91F5B1416E620" modified="2018-10-10" version="1">MVLIDKQEYVSKEEVRLKEDREHIRYWKRWGPYVAERQWATVREDYSENGDAWSYFSHDHARSRTFRWGEDGIAGVSDTHNLQNIAFAFWNEKDDFLKERLFGLSNPQGNHGESIKEAHFHVDNTPTHSYMKYLYKYPQKKFPYKELVEENAKRGKQDREYQILDTGIFNDNRYWDIFIETAKEEDDEEELLFRIIAYNRGPEPAPLHIIPQVWFRNTWAWGYEDQKEKPSVEKVQDLVAKTTHQKLGERYVRFAPSPAVGDSQEDVFPQMLFTENETNNEFLWKTKNNQPHVKDAFHRLIVNGEKESVNPENKGTKFAAWYAFNEGEGIPPGECAVVRFRLSRKMHQYFDEEVLDNVIEQRIEDANDFYYNISPLPMSHDLRNIQRQAFSGMLWNKQFYHFVWDQWANGDPGMIPPPPGRRHVRNQQWKHLYMDDILSMPDSWEYPFFCAWDTAFHCIPLAMIDPDFAKRQLDILTREWYMHPNGQLSAYEWNFGDVNPPVHAWATFRIFKIERKMYGRQDLDFLERVFQKLLLNFTWWVNRKDSEGKNVFEGGFLGLDNIGLFNRSEPLPTGGVLEQADSTGWMAFYCLCMLNIALELAKHRRIYEDIASKFFEHFILISDAMTFKSGGQETSLWNEDDGFYYDAISYGDPWTQQLPVRSLVGLIPLYAVLTLEPELINKFPSFKKRLEWFVENRQDVAERNIASMKHRGKDERLLLALVSKSRLEKILKRMLDETEFLSEHGIRSMSKYHEEHPYSMEVNGQMFRVGYVAGESDSALFGGNSNWRGPVWLCVNFLLVESLLRFYMFYGDSFKVECPTGSGEYMHLGHVAEEIQHRLQHLFARNDEGRRAVYNGSDLLDYDEHWKDYMWFHEYFDGDTGRGLGASHQCGWTGLIAKIIHDTGINCRVPHTPRTPFAAASHYFDDSFSRNVRSRGGSRRPSMRRSSTSRSIGNRSDFESTFTGRDTPAPESALDDNERLGESGLGDEHNDHVSQYVGRELERVRSHVSMGAYEDEFETQADRIPNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WU90</accession>
    <name>A0A317WU90_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_534153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468302.1">
        <property type="nucleotide sequence ID" value="XM_025611476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WU90"/>
    <dbReference type="GeneID" id="37113619"/>
    <dbReference type="OrthoDB" id="5386823at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="118" mass="12765" checksum="8DD03670C332BBD3" modified="2018-10-10" version="1">MSDRNLMDIEPGGESTPYESIRLFTETPEKQTGQLGGQSQHTVSEMRTTLGDEGDEEENENRFRDTPLARQLEKGEATSGLSGIVDKDLKPKTPEEGAALAARIRREQGYGPGSGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW67</accession>
    <name>A0A317WW67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_574343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469014.1">
        <property type="nucleotide sequence ID" value="XM_025615015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW67"/>
    <dbReference type="GeneID" id="37117158"/>
    <dbReference type="OrthoDB" id="5511210at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF6">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016303980" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="278"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY90636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="32757" checksum="4A028507D0EA3C2F" modified="2018-10-10" version="1">MYFQGYLGRIVCLVWLLLALQDAWFVRAEGFTFPTSTEDKFIVGDLVNVSWNVVTSRISLYEVCSSAVALELNVTNDFSYVWNATRDNYRESGCAFELAPLDFNGNPNPPNLTSEMFGVSKRYNDDPAPVSYNFYGTTTTSTATATSTSVTTSTGTHTSTSTSTSTSTSTSTSTISTAVAETSAAFSTQTAVAQKTGLTVAQKVGIGLGVPLGVLAIAAIIGALAFLYRHRLRKERDSGHFPTMDQAASPMVVEEAKVPSDPRMSRAETLIAELPSHSDLGGIEEMDSNRPISELMGTPRNELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WX39</accession>
    <name>A0A317WX39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_25252</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468839.1">
        <property type="nucleotide sequence ID" value="XM_025606443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WX39"/>
    <dbReference type="STRING" id="1450535.A0A317WX39"/>
    <dbReference type="GeneID" id="37108586"/>
    <dbReference type="OrthoDB" id="3944240at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="297"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY90461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="691" mass="77343" checksum="3A4EF90F0F3F8C8B" modified="2018-10-10" version="1">MDMNMSGMGSMSMGNGVPGLFYLQKMYWAVIGSAIAAGTVINLLNRFLACQRLRDSSLTPSKPKSIFFGTYATLTALVREASYATLPPLTIRGHSYHFAPLGPLAIILANLIVVLVFCFYKLDTADQWKWEDVGYRTGFVAICQLPLIFLLAGRQNLIGILVGMSYERLNWYHRWIARTLWLTATIHMCFWFRDWGRYNYILYELKHYPLATRGFAAWCILTFIVITSAAPIRRFGYEIFVLQHLVTFVGFIAAVWLHAPAEVKVWVWIPIGFLIFDRVARYLWATYANLSIFHRSKNPTHALWANRATFTPLPGNVTLIAIENPGIRWKPGQHVFLTCHSIVPLQSHPFTISSIPGDNSLVMYVRAEKGGTRRFFRYASKNHHVLRGSDTSPAKEARAAFVEGPYGCMRPLQQFDSVILLAGGMGATFTVPCLRDIVARWRTESTQGQSSKLTRLAATKRIRFVWVIKSRTQLSWFESQLQSVLTDVQECQLANPDIIREIEMSIYITCDEKLEPAQSTLCAQASQFQPQTTAVPEKTVEKFSEKATTEEKDNISVDSVGQSGCKPGGGCCCTASIEDEEEITETKCTCSGHAAPLSTDINPPAPEADTKPEIPISRPHDLTILSGRPHARTIIRKVLEKAEGESAVVVCGPRGLSDDVRRSVVYLSDERAVHKGTGAQGIYLHVEQFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYC6</accession>
    <name>A0A317WYC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_555206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469087.1">
        <property type="nucleotide sequence ID" value="XM_025613775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYC6"/>
    <dbReference type="STRING" id="1450535.A0A317WYC6"/>
    <dbReference type="GeneID" id="37115918"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY91359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="263" mass="27400" checksum="ED7212F3B16DCBF2" modified="2018-10-10" version="1">MSINLTGKTCLVTGGAGGLGKAIAARFFSAGANVVICDVNEERLRQTSLDLAGPDGDARLKIIKTDITSATQVQTLFDEIVTQYQKLDILINNAGIMDHFDPVGDLDEGLWNKVIAVNLTAPFLLSKLAVRNMLAQEVVQGCIVNIVSLAGKAGFMAGAAYTASKHGLVGLTKNTASFYGSKGIRCNALMMGGMMTNITDAFMSNINMEGKDKAVGLMTAAGVPLCDVDRVAELCLSISCGPGAELINGTCIPVDHGLSGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZD6</accession>
    <name>A0A317WZD6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_533202</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469472.1">
        <property type="nucleotide sequence ID" value="XM_025611289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZD6"/>
    <dbReference type="STRING" id="1450535.A0A317WZD6"/>
    <dbReference type="GeneID" id="37113432"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000563">
        <property type="entry name" value="3-oxoacyl-acyl carrier protein reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY91744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="283" mass="30482" checksum="2926342DBD697F05" modified="2018-10-10" version="1">MITGGTSGIGFAIADRFVQEGASRVILVGRSYERLYNAATRLNISPSIRRTQSTGTQETASIEFQRHHLIETSEKINLLVGDISEAGSWARELERVMQTTNLDILVNAAGLSISSILPKSEPPDISRILRTNLEGSLLTSRAFIRASIRNRMKKNRDTSSSNPPAPSKCIINISSLLAHKSGTGAVPYAASKAGILGLTRSVAVEAAASLRDVSIRSNVIVPGYIETPMISDFSEGETTRLKDLIPLRRFGRPDEVADAAVFLAQNEYANNCVLNLDGGLSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZF8</accession>
    <name>A0A317WZF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">XAP5 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_554928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469451.1">
        <property type="nucleotide sequence ID" value="XM_025613754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZF8"/>
    <dbReference type="STRING" id="1450535.A0A317WZF8"/>
    <dbReference type="GeneID" id="37115897"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="3">
        <location>
            <begin position="191"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="388"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="427" mass="46812" checksum="F7210DEEE2E4ECC4" modified="2018-10-10" version="1">MSQSEQPSHSSTPRSFTSQTVSAEDLLKSQTVGLVHLSDFRKRRAEVLEQKEREAHDKSLGRFTPGISRSATPSTGEGTDGNSTPRSEGPPKKKKKKPISKSKLSFGDDDEEENDSAADAAATPRDSSIPRSVTKTPVGDSSAPSSRRITPNPNAPPPPKAMTKAALKAEAETRDALRKQFLAMQEAVKNTEILMPFIFFDGTNIPAGTVRVKKGDPVWLFLDRCRKVGAELGVGGSSGASKGRKDNRREWARVSVDDLMLVKGEIIVPHHYELYYFIANRIPSYSSTGGLLFDYSDKPPLAISKDDPLSRPNNDDIEGADKDPSLTKVTVLVNPDDAVATVLNPTEDYKTSVLSGLDPNTIMECAGRALLFWTYQTTQEIFYQKFLAKTLTEKYTNLNTQLDKVIHNANSEISALQARVSVNITIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0A2</accession>
    <name>A0A317X0A2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_461477</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469711.1">
        <property type="nucleotide sequence ID" value="XM_025607927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0A2"/>
    <dbReference type="STRING" id="1450535.A0A317X0A2"/>
    <dbReference type="GeneID" id="37110070"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000115">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF307">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="9"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY91983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="437" mass="47999" checksum="87091CB7F1BDF0E7" modified="2018-10-10" version="1">MEQAKTPLQVIVVGNACLTQAGIGGMAAALTLGLRGHHVTILESAPKLMEVGAGIQVSPNMLTLFDRWGVSPLIHAKDVALEHIHVRRWEDGSILATLPVNKTYGQQTVIHRADLHNALIEQALALSNVELRVNSPVAEVQFDPAAVILANGTVVEGDIVIAADGIKSLLRGQLLDESSIKAIPTGDAAYRIMLPRSALENDPELKTLVDEPQATRWLGPGRHVIAYPVRNHEMYNVVLLHPDCHGVEESWTTKGSKQAMIDNYKGWDRRVTKLIDMVADDDVLEWKLCLHAPLRTWVKGSVALIGDACHPMLPYVAQGAAQAVEDAAALGVLLSTITSRAEIPTALEAYQKSRKPRAETVQQSGSENRITLHLPDGPEQRARDEQFRASLKSGSNPDRWTDLETQKFLWGWDAEKAALDVWNELHGNHVSELRHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X148</accession>
    <name>A0A317X148_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_20915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468628.1">
        <property type="nucleotide sequence ID" value="XM_025606143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X148"/>
    <dbReference type="GeneID" id="37108286"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY90250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="123" mass="13813" checksum="240552A3685D0CC7" modified="2018-10-10" version="1">MQMICCLTASRGLSSAAVESFSSKHIGSTLFQTALVWETRIDSLQSFIGIWSILRVGRAIHESYVSLIMYSFPWSLSREQRGHLLPTMKGYFTMSIDAYDSIAQIPDPYDQNIIIEPSTASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1V6</accession>
    <name>A0A317X1V6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_463054</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468908.1">
        <property type="nucleotide sequence ID" value="XM_025608003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1V6"/>
    <dbReference type="STRING" id="1450535.A0A317X1V6"/>
    <dbReference type="GeneID" id="37110146"/>
    <dbReference type="OrthoDB" id="21557at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="155"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="238"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="275"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY90530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="328" mass="35292" checksum="0C6774BE2DA24E04" modified="2018-10-10" version="1">MGEPNGTGEHGSSFPPGTLAKLTCEILDDTFYNIIHDIVAKVHRDEKVSRMRSAVVTARQKADEEAAKRREESGKPAGAFKPGDLDFEELKDIHVETDAAVFDEGKVYLKGNPLQTTKEIICPDCRLPRLLYPVTGVGARAPPDPYREYCQKQPMISKPGHDVHGNPFATDKLNPKKKKQTNTSNTPASSPPTTPDSSFKQAAPEKVSFPTVKCPNCPRYFVVTRVAQHLDRCLGLSGRQANRNKTPMENGASTPSSAPPKRPLVDDDAPTALPPKKKKLGAPKKLSGKKPPPPSKLKNGLTPDMAAASDAAGSGDGDIKTEANGDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4A0</accession>
    <name>A0A317X4A0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_555227</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469108.1">
        <property type="nucleotide sequence ID" value="XM_025613777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4A0"/>
    <dbReference type="STRING" id="1450535.A0A317X4A0"/>
    <dbReference type="GeneID" id="37115920"/>
    <dbReference type="OrthoDB" id="2571985at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02215">
        <property type="entry name" value="cupin_QDO_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY91380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1011" mass="114271" checksum="D0CA2C64902B9F1C" modified="2018-10-10" version="1">MSLSFTERPPQGRIPYAIPQLEGERITIPGSKGAFRILASSKQTNGLMAVFQSGAVLSDAPGFHYHNHAHDVFLVTKGSLKLWNGDKCRVMGPGDFAYVPPTVVHNPELLGPHTETYGVVTPGDWVDFFRYVSEPYDGILVPEDDDRDLKSLLIPKVMAAKQDFDVVFQPHYQPPELGEWTKDEERLPETPQPYFLRANTGPKWMLGGVMSRPFITTSQSSGVCAISSIESSHTYGETLLSKFMTFQSVDHCLCVLEGTLTVRLKDSPEATFREGETVVIPAGQAFALGFASRYVRVWSFTDGDGIETLIHRLGKQFDGAVLPDQAPELDTADVKPVAEALDDSPPIIIAEDDSLPPPRAKRPRAAQACDRCRAKKYKCDEQYPCSHCKSLYVADLERKVDELTARLYLAELGITSQQSPSLQKAKASSGTQQLPQVGIEATPLSLPRTGSTPREEPPSLYENHDEAGESVGDEISELNHHTNGIEFHGSTSSAALLGHLQKARDPQRPLERRDARAEELGYSIVSTLHNSSFSPSGTGSAQTLTLREQNYYFEQAHAFINGYFENIHFIHPLIDKEDFLLRAHDLWFNRSLQPEPCFIALYLSILSFGALVRVWDEERLGGLTRFEWSRKLFGEAQMYLNYLQFSNTLDTVQCLYLMAKICQNELNPNLAYMYLGLAIRTCLAAGFNREVRSSTEQRSGWISKTWWGLFSLEIEMSFSVGRPDTLGMDEYHNRALPERDESEYAIIPWMVDFAYIIRKVSVQIYHSRITLQEKLHLALQIETELDRWMARLPDRIKPDVLQRATAGTLRDPKWARRQRLVLGIRYYNVKMLLFRPFLSHFTRKLRHTPMELEETIAKCLDAAMKTIQVIYDIYRIHTFFRCWWYNTTYVMFATSTLLLPMSKLGMCAETIPLRRSVEMAVEILEAMDESVVARKSVEIIKHYLREFRPIDVQTTAGSSDGNKIAEFADPGSTQSGFDIPEWAYGFGFPDCSFEGIARLFDDLGGLPMLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4Z7</accession>
    <name>A0A317X4Z7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_554393</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470417.1">
        <property type="nucleotide sequence ID" value="XM_025613710.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X4Z7"/>
    <dbReference type="GeneID" id="37115853"/>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="11">
        <location>
            <begin position="601"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="10">
        <location>
            <begin position="865"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="680"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="962"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1172"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1210"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1399"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1210"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1243"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1275"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1418"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1440"/>
            <end position="1454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1454" mass="159593" checksum="F6ED263AABE51CAB" modified="2018-10-10" version="1">MLRDELLRSKKDEIAHCLSSRKRKLSELYFATVGFAGATENAPAGSPYHQKEQAFLDANDLSKGRYFNEATLPPLPDYTSILARKFKHQVEEERKVHDAAVAQNAGAQATAANNERQSKPRQGSEQKPSGSKSEYLAPKASNQVAPAIASQVPEIPHVLIPVDTHPQHVGTETKVPLSKQDSYRPLSIGNAPVEASASAAQAHPTPAASVSSPRTPDVSLSSKKDDVRSILPHGRTAQVPEQPLSPVSSAGPCSNNTPAPVTVSPVTSPAEEMNNATDKVPTPKDEEAVKAPPPSLVPSTPDEQLRLEEAQSLQQNSLAAVKTGGDGIDGGATTSEVIQEDVVPAPAAVKETPKVTAELAPIAAPLEPKRHDGVVEPADESHPPIHQPALVPQAEAGAKVPTEMAPVLKKPTPPTHPLPSPPERMTTRVSSGAIRHKSVSEILGEVPKTPVSQSDKGTVAEKPAEMARDVSAATPDSAARMRFKDRKAREKERTKLSTVVFPKQQQQQHQTQEKNDSMELVRQHAGDLAKLNEEQDYLFTLFQNRAYAPPRGTSLSTLIASAHKTLTTSNHFLDYQEQMDCRTLRRIYSLQNANRWPLRQLKRSVEPPRAGTHWDVLLNHMKWMCTDFREERKWKIAAAKSCADWCAEYVNTDREHRSLLRIQVKGPALGAENRVEIKPSMASPPQEAGDEMSHPTPDLVPSTEEDSVSEGFNDEPRHDLHDTVAPAAIFSLGIDEFTFSLDMTPAAQKLLDELPTYTPVTITSDTELPAFKEPPDSVWKTEILPVSKYASGKITFHDDEPPPKRSRYDYSQYQSDPEQAVLDLPPEQINVALFRPENRHIRDRIHPGHSFRPPTEHPMPSVGFFESRQSSQWTYAEDDELRRLVKDYSYNWSLISNCLTPSSQFTSGAERRTPWECFERWVGLEGLPADMSKTQYFRAYHQRLETAQRTVLAQQQAAQQQQQQQQQQQQQSTTNNPQSLPPVRRRTTQPLRVDRKRSSKHLALLDAMRKLAKKRETMLQKQQHASHLASLRKVNEANQPKPPISSPAEFSRLKYERELKLQERQEQYRQQMIAQQRANIAAQRAGQVPNQQPMMNAPGRTPGAMAHNPGNSAMTGNATNGMPSGLPNGLPNGVTPAVGANQARPHMQGMPNGTPVNPPTPQNPMTMKMMPQSGIQQNSNGARPGMPMQTPPDNTRVIREANRLQEQQRILQTRQQQPHQQPLGQSQHPQQQFHNQPQFVPQGSHSPNPNMPNVNGTPNNPAMMAALQAGGGMQSPSFHNATPQGVSTPSPRMGQPNLLSGGVVPTISNIQSQIQRNNPNMPPEQVSKLATDRLHQYQQQRMSQVAMSAAAGNIGSVQANYQVDANFQSPQPGLNGGSGMQVPQAQGFSPMMRVPQPAQQNRVGVGGSPAMNGAIPQPSRSVTPQTQRSGSAQAGAVAGTSKSPNPPQAQTVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5K4</accession>
    <name>A0A317X5K4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_572424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470614.1">
        <property type="nucleotide sequence ID" value="XM_025614923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5K4"/>
    <dbReference type="STRING" id="1450535.A0A317X5K4"/>
    <dbReference type="GeneID" id="37117066"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF2">
        <property type="entry name" value="TERPENE CYCLASE AUSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="29110" checksum="55FCAF8F6636F9A3" modified="2018-10-10" version="1">MSANPVEPPDPLNSAWILPVSAVGMLLWCVSYILMIREGIRTKSYSMPLFALANNFAWEIVFTLHFADTPIKNAAFLMWAVIDVGLVWQTLKYGKYEWEHAPLVRDNLGKILFGLTCWCMLGHWLFLDWWFSRFEDPTECKFWDGGLSQLFISVLSVNQLITRGHTGANTIAIWLTRTLATILMPYVPLFWRTYTWPETYSYVHMSLGVYLWSTALVCDLVYGILLVYISKREKVLPDGRKVSIYAEHRKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X694</accession>
    <name>A0A317X694_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_583392</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469913.1">
        <property type="nucleotide sequence ID" value="XM_025615558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X694"/>
    <dbReference type="STRING" id="1450535.A0A317X694"/>
    <dbReference type="GeneID" id="37117701"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="56"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="661" mass="73308" checksum="6DB1E83AAAF373DD" modified="2018-10-10" version="1">MSSYQPFQCLVCLRRFTRHENLKRHSALHSRSRNDVSLPCDLCQATFSRPDLRHRHMKRKHAEHEHRRAIKRPRRDESFVRAIDSHSIQPEDLAVDSETETPMQHQRSHRHHAQSADLPRTTTRDKGDQTQLDTDTLTQLTSIVPDATGMEQTLRSILKPTDQLGPQSPAMTISQSPSLDIDLSGFDFGPDISPSPSKDDLTQPQTDRFPTAVQITRGCDLFFTNVAHFIPFLHQSTFDSTTLPSHLLLAMLSLAYQYGDDPECDALKGTGASLSTRCFLQARTVLPSTNAISTNPTDQLALIQTLLLLQICAMLYLCGDYSAQGLQMHSNMISLARSSGLMQPIPTESAQTSCLASLWEEFIKAESHKRTLFAVHQIDALWYQLLSIPRAISHLEVKHDLPCPESLWLASSAADWAHRRLLAPHPATNMQYADAVRHFLSSALTDPPTSIVPAFDPYGAINIAHFLISSAREISGWSTMTGMLSMERFSALRSSLVALGMFLHPQDTPRTTAITATAPATWETAMLELQIWSPSHTGGIIKSSIDTMLQQATDLAPSAGDILCEAETAKSFQSHVDWFLVYLDTTVDVAGEAPWVALYAYKAFLVAWQLVRGGVPGAMQAVGVRDGDAAGAVKWARRVFSRREKWGVGRVIGGCLDRLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6N5</accession>
    <name>A0A317X6N5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_533051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470073.1">
        <property type="nucleotide sequence ID" value="XM_025611256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6N5"/>
    <dbReference type="GeneID" id="37113399"/>
    <dbReference type="OrthoDB" id="10499888at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="228" mass="25058" checksum="1A73FEEF348D4047" modified="2018-10-10" version="1">MVCVSNVSTVRQFRPAFPGDYSPVSLTNNTNRHLAAGRAAWTGSGSGLTCFYAPVEEGMTAAARCGGCPVSSLWIAWPAESIATGVKSSHATTAYQCEPAEARARFFLDATGLITFPPVWNPPQPPFCDQSPRAVPEMLGAKTTNRDPSGDDRTYSLCRWTEESVLTYMRIYMQLLETMMKISVICNSSLQTSPCCCYLRSMFRCDRFEVCDLGVEVGDGLTFRFSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X784</accession>
    <name>A0A317X784_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Monooxygenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_457074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471215.1">
        <property type="nucleotide sequence ID" value="XM_025607725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X784"/>
    <dbReference type="STRING" id="1450535.A0A317X784"/>
    <dbReference type="GeneID" id="37109868"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF127">
        <property type="entry name" value="TYROSINASE COPPER-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016432995" evidence="2">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="353" mass="40607" checksum="4613A717063A52C2" modified="2018-10-10" version="1">MLFLCVLCVLCVLPSAHLSYAQQPQKCSKLLTRKEWRTLTFSEKAEWVGAVKCLASIRHERLSLTKDQTVLEGKRSLYDDFSYAHASVEHSVHRNAYFLPWHRWFTYLFDTSLRHTCGYSGPTPYWDWSRDHADLFSSPVFEDSPEYGLGGTGDCDSSPEADCTVTTGAFAPSAGNFELAWPIRHSLRRNLTLITGWYPHEQPQNRTLGPDFVRNLTEQTTGDFFRFQHAMELLHNHVHNFVGGDLAGDCPKVLPEEDCQGMAISFTPNDPLFWLHHAQLDRLWSEWQRHHPSNFAAFSGVPLTPYNMTDPRYDLDAHADYQMPFDVLSVAMTPRMVFDTEGWPLCYQYIDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7K8</accession>
    <name>A0A317X7K8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_484731</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471355.1">
        <property type="nucleotide sequence ID" value="XM_025608969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7K8"/>
    <dbReference type="STRING" id="1450535.A0A317X7K8"/>
    <dbReference type="GeneID" id="37111112"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21381">
        <property type="entry name" value="CTWD_TTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000611">
        <property type="entry name" value="TPR repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="299"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="415" mass="46975" checksum="77A652ECAB7D93E0" modified="2018-10-10" version="1">MGQIEELPDDYDESLDLNQPQPPAPEELPIPIKEERLKDINDNADPLAPKMPPAMEAVNTHTTDELAEILNRTPLFMTDINKAYDEKGENVMLDAIRALQNEGTRGEVAQNFREQGNEAAREKRWVDAKEHYSKGIAVLLAKEDKWDKPEDEKEEVKLRREAEEACYINRALCHLELKNFRSTTLDCAAVLKLNAKNVKAYYRSAMALYALDKIVEAEDVATRGLELDPMNKPLQVVAGKIAERKGVIERIAARKKAEDERTRKEKNLLSVALRARQIRTRKTDQPPEMEDAGIKLTPDPLSPESTLEFPTVLLYHMDAQTDFIKGFSEMHSIADHLDYIFPLPWDENKEYSMNTVECFMETVTGGLIRAGKKVPLLQILSGGKVEVVDELVKIYVVPTSKTATFIAEMKARKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7W2</accession>
    <name>A0A317X7W2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AEX-3 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_281953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471455.1">
        <property type="nucleotide sequence ID" value="XM_025606630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7W2"/>
    <dbReference type="STRING" id="1450535.A0A317X7W2"/>
    <dbReference type="GeneID" id="37108773"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF31">
        <property type="entry name" value="DENN (AEX-3) DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="3">
        <location>
            <begin position="84"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="784"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="526"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="823"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="918" mass="102836" checksum="974E930357AF54C1" modified="2018-10-10" version="1">MGPSLRDHASFVRPSTRDRPSTRDQGENSLVVPSRTSSLHSRITQPIPSQANPKAAQRTPKTLTHAYMVCGVGREPSQWVRAPAPAQGKIGHMKGAVGQFWLPEILGSSPRLEQDNEIAKSLHSAMRACFPHDVEICTGKSQPHCVHHAFVLQQDSSHTLYGIALRVWSRADDKRAETIRELRKKTEPDFYDNPEETYWIPYCLSFLSRYPLYDLLGDYLRGMWIHWNKATNLFHAEEVSRILSFPAPRLNDLVRIDMKDYALCYQFPSSPTGFQNFSMWPLFTCLSIPNVVGVVEAAVSPTRRIIFVSHYPAMLTMAAETIRYCVRIYEWSGLYVPVVHARHIKDLVQEPGPYILGVTAECRTLFNAPSDALVVDLDRNFVLTSSPPDVLSPGQRTKFINRLTQALNGDVSPSGVPNHLRSAYAGGKLIPAGQIIVMRGEVESVQDPSWWNQDAVMHVMDHVCEKLGRNTGMKAIFGGSVKKPLMTKVSMRHLNEIVRERNQYSRDAMEAWQDFINLKGRMDTELSKVTKRNNFLVEELETWKQQFLKFQAFAEQLTKETSELKVKIENHKRENRRLTGLIDQQKDDVARLSLRLSGTEKQRDDALEALVLQQEIAEELERERKRNQKELASLQHTNVSLARQRDEAQRVVLGLRSLINGQTHHMEHIVRSIGSSADLTELAEHEAAVETKTTEYEAVTPRGSAASSRRSSANVSAKGIANNVSPDLEQHLLNIGKGHNRLARLSITDVADRYLRDKTDAISDIIRSISEQCAAAVEGLQLAQDAEDDDSDVTGKATPSGRRLVPEGGRGHLTPAGSEMGDSDNHSLHPDHRRSSVPPTPDLVHNRSSTSMSMVSSSTFPERSSQQYGPGEFPTRIVEDDDERAHETDGLDDHTETGTLSKQASEDLMRSGSSRLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X801</accession>
    <name>A0A317X801_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_484394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471176.1">
        <property type="nucleotide sequence ID" value="XM_025608954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X801"/>
    <dbReference type="STRING" id="1450535.A0A317X801"/>
    <dbReference type="GeneID" id="37111097"/>
    <dbReference type="OrthoDB" id="4448936at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="286" mass="32332" checksum="AD3687BC2EA297E3" modified="2018-10-10" version="1">MDHPPPSQYDELSPPSSVAGQIWDMALTDPDYASHILDTENAAAPLSARLTRLAHLASQFNPTSKSDSVTLHHCLDTLESLLDPRPGLTQEVARCRPQSLSRSSNSAASISTTDSQETTDSLISIGEMSHPQLKDILGEVAALKVEFDQRRKESSDIYDLLTQERQALAQRITGLEEEIRELNMDILEDSAEREAIQGTIRGLESWVDEWHKQRLLIAARKQGSASRRNGQRRWTKCKAEDVDGDGEALFEGITGWMRGWKDVEEVFRIRERNRSLRREERQQART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X856</accession>
    <name>A0A317X856_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_282208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cell membrane</location>
            <topology evidence="1 11">Lipid-anchor</topology>
            <topology evidence="1 11">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471470.1">
        <property type="nucleotide sequence ID" value="XM_025606636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X856"/>
    <dbReference type="STRING" id="1450535.A0A317X856"/>
    <dbReference type="GeneID" id="37108779"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000032">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF4">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 11" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016194296" description="1,3-beta-glucanosyltransferase" evidence="11">
        <location>
            <begin position="22"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY94709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="498" mass="53028" checksum="D460EE09E51ECAFB" modified="2018-10-10" version="1">MVPTYAQLFAAACAFATTANAVTPIEVKGMDFVNSKTGDRFQILGVDYQPGGSSGFSSTEDPLGDADACLRDAALMQSLGVNTIRVYNLSPNVDHSKCASVFNGAGIYMILDVNSPLSGGSLDRTDPESTYNSVYFEQVFGVIESFKNFPNTLGFFAGNEVINEQSVYEAPAYVRAVVRDMKDYISANANRSIPVGYSAADVRPILLDTLDYFMCNMENSTSSRSDFFGLNSYSWCGDSSYTTSGYDVLTDDFSNTTLPVFFSEYGCNSVMPRTFTEVQALYGKEMDQVFSGGLVYEWTQEANDYGLVAINSSDTATLLRDYEYLTEQFAKVDMTSIESSNSTQTSQEPVTCSASLITNSTFLNSWDLPTRPSKVADWIKSGYTNVTAGTLVSVSSTAIPQTIYDYNGNKVSDVKYKVLSSDESNTPNNSTSLVSSTSNSSSSSGSASASASASASASASASASSSAASSVSGATAGHLSASFMGLLTGATLFAVFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8P5</accession>
    <name>A0A317X8P5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_509263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471416.1">
        <property type="nucleotide sequence ID" value="XM_025609693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8P5"/>
    <dbReference type="STRING" id="1450535.A0A317X8P5"/>
    <dbReference type="GeneID" id="37111836"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016190008" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="32"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY94655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="558" mass="60648" checksum="CAF15A5BAB9C0A42" modified="2018-10-10" version="1">MRAVSTLAGLAAAAPLVASASIRTRSAGSDLPIVNTTLGNVQGTFSPFRGGDTAVVYRGIPFAAAPTGENRWKAPQPAQAWDGVLNATEFGPQCAQSYSSAGIFSSGKESTSEDCLYLNIWTPNYNDTSDLASKNLPVYFWIYGGRFEGGSGDVPTYDGTGLAAKDIVVVTINYRLGPFGFLAHPELSAESGHNSSGNYGILDQQAALRWVHENIANFGGNASQITVGGQSAGSASALDSMWSPLNEGLVAGVISESGARGPHDPMTGSAATSHRTKAAAEAQGVEFLKEMNVSTIAELRTQVSMETLLKYDSLSDTTFDNTQFANLSAFFMDPPMWRPNIDGYVLPHDYTQALALNAHADVPILTGNNKDESGASTAPGLTVATYQELYSEAFLNFSQDFFKLYPGDTTAQANNNSNELYRDMSRIGTWQWALDWTAGGAKSPVYTYYFTRYPAENIADGAYHGSELWYTFNNIPYSDYSNVTWAPYDYKVEEYMSNYWANFIRTGNPNGDGLPEWSPSTETKQTMWLGDSWGSGPISDSDERVEFIESWFATMPEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X978</accession>
    <name>A0A317X978_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Developmental regulator FlbE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_572272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471482.1">
        <property type="nucleotide sequence ID" value="XM_025614914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X978"/>
    <dbReference type="STRING" id="1450535.A0A317X978"/>
    <dbReference type="GeneID" id="37117057"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26275" checksum="A2E49B8BA165E1B0" modified="2018-10-10" version="1">MPVYMLYGFRWPRAGFTGIRVYIVLHNLEDATAEYIQQPLTTSLLLSSFQKTDPDILSRLPSLRFIEQYDPEDTSDEAVSKPHAYVGAKVISIPEAGGEPLPETSWKPEDIFQESPLGEEEMQALTEFRDKYAAGERIGWWIVYNGDPERWFPVDEEGEMGLGDGDSYGEEYEGDSYGEEDDGEGREYGSDRTQTPPETPSSATVGLCFCSSWSLQMRLPERLTRLFARRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAJ8</accession>
    <name>A0A317XAJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_506722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472374.1">
        <property type="nucleotide sequence ID" value="XM_025609584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAJ8"/>
    <dbReference type="GeneID" id="37111727"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="335" mass="38432" checksum="29FD632B18AD001A" modified="2018-10-10" version="1">MYRPNSLWTWSFCIVTLIQTIITLALEAYVFANFQIQLFPKGEVSTASKTVTTFLALYCFGFIYELVLVYDALRLKNTIQVIGLCVCNLGLLIYGAVQVQQIKDSIEMLVAESAITVDVWGETEPFLIIIPCVVAMGSVLMMIIAWKLYDEFAWSIYKHISADLRMKRRYLTYQIYIALLKFDFFFFLGFTVQFLVIVTNKTDVEFGLTTAAIPVTILILICAAVFVKRESSVGMIIVILLYFAAMAYFLFKLVRMYQPETYQEYLPARRSLTFFAVITLLLIVLTIINACICMHNFHKGLKQHVYKKKSRDKDEKTTELSSNMSGQVPSRMMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAT3</accession>
    <name>A0A317XAT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sphinganine hydroxylase BasA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_224006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472052.1">
        <property type="nucleotide sequence ID" value="XM_025606239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAT3"/>
    <dbReference type="STRING" id="1450535.A0A317XAT3"/>
    <dbReference type="GeneID" id="37108382"/>
    <dbReference type="OrthoDB" id="408954at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="7">
        <location>
            <begin position="206"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY95291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="426" mass="48481" checksum="AAFF07F0C08CA0B9" modified="2018-10-10" version="1">MATNASVIFDLPPLPTYSLTPRPPVLAPIPDNILALMLPIVAYWALSMVYHYIDVNDYFPQYRLHTPAEVLKRNRVTRWEVVRDVILQQVIQTIAGYAVSYFDPPDYLGKEEYDIAVWARRIRLMQRGLPHLLALFGVDALGLGKNLSHNGWTMLGGAIAGGHYPAFTQSIILDSGVEAVAPAFTRWELSTASFMYWFFIPALQFIWGVCVVDTWQYFLHRAMHLNRWLYVTFHSRHHRLYVPYAFGALYNHPVEGFLLDTAGTGVAFLTARMSIRQSMWFFTFSTIKTVDDHCGYAFPWDPLQHVTSNNAAYHDIHHQSWGIKTNFSQPFFIFWDRWFGTQWQGEVKLRYERSRETAQKQLDNDASSATNSGVDTPVSGSVTPVSAVQEAPSESVSRTRRRKTVTLSPHVDGFKGVNHSVASSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB35</accession>
    <name>A0A317XB35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose reductase [NAD(P)H]</fullName>
            <ecNumber evidence="3">1.1.1.307</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_506708</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>xylitol + NAD(+) = D-xylose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>xylitol + NADP(+) = D-xylose + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27445"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.307"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.307" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472366.1">
        <property type="nucleotide sequence ID" value="XM_025609583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB35"/>
    <dbReference type="STRING" id="1450535.A0A317XB35"/>
    <dbReference type="GeneID" id="37111726"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="UniPathway" id="UPA00810"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032866">
        <property type="term" value="F:D-xylose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19115">
        <property type="entry name" value="AKR_AKR2D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044487">
        <property type="entry name" value="AKR2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="14">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="13">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY95605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="319" mass="36072" checksum="3F2AF0CCAEC983C9" modified="2018-10-10" version="1">MASPTVKLSSGYDMPLVGFGLWKVNNDTCADQVYHAIKEGYRLFDGACDYGNEVEAGQGVARAIKDGLVKREELFIVSKLWNSFHDGDRVEPICRKQLNDWGIDYFDLYIVHFPISIKYVDPAVRYPPGWMSESGKLEFGKATIQETWTAMESLVDKKFARSIGISNFSAQLVMDLLRYARIRPATLQIEHHPYLTQERLVDYAQKEGLTITAYSSFGPLSFLELDVKNAVDTPPLFEHDIIKGLATKYGRTPAQVLLRWATQRGIAVIPKSNNPERLRQNLDVTGWDLEKQEVEAIGALDRGLRFNDPLGYGLYAPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBH4</accession>
    <name>A0A317XBH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_530657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472677.1">
        <property type="nucleotide sequence ID" value="XM_025610719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBH4"/>
    <dbReference type="GeneID" id="37112862"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="362" mass="41338" checksum="B695B289C18016EF" modified="2018-10-10" version="1">MVDLQQVADYSEELNIDTTLLYSYIERHGDRDIDSLRELSPEERASSRVLSLIFEQEQLQPYLRWRADRQDRIQVDYSNYTIPDSFGAESVSGNEDAAATEDCEVIMPGYNAGFSLHRDKAIFIPALREEMASVFESRGSGWTVLSLGVVAHDTTLYLLLPTALVHDYRARVEDRINGDWVDTDVADPTFDDQIEGLKRWAPERTRFVGRRVDVHGDAGSHVCDRVKEVLVAAVVDSSLPPPITCTIVEAGHEVLQVLDTHMKRLTDWWRPSKDMSKEQTLGMANYDTMEEYETPNYHDEVHCKSPEEGTYNAPSEQREVYVKYRVRGGYMLSNGKFARDNAWGYNPYTSSFLSIRKIFGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCD7</accession>
    <name>A0A317XCD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_571877</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472038.1">
        <property type="nucleotide sequence ID" value="XM_025614890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCD7"/>
    <dbReference type="STRING" id="1450535.A0A317XCD7"/>
    <dbReference type="GeneID" id="37117033"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY95277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="355" mass="41089" checksum="B7269E03F1B7C03C" modified="2018-10-10" version="1">MTTILTIPTRISTRPSLLPRLIPSILHPPLSCHVRQYTRNLLYTSRAEPLEPGTTVTSDTNQTYKIEEVLFHAEKTTLHRPNQTIHPQEPNPGEFDYQRDIHNQLSPYPNIRTVIDTIQESETFIYPILKTNLLQFPQKNLSQATRKQILRSALQGLVDMHANNIHQTQQHPHRLHSPGNHRPRNHHYNPSPDRRSGGLSDHPPGKWIKGPLCGNAMWRSPESWARASQDQASDVFSFALVIIYVMHKHMPFYIPGVELNTEDAWRHILPLHLSYFADIDGLELFLGHIGEDNPYFQCMLELVSTFGPENPIKPIRRWTVLEPELRDLVERMARLDPRRRITAEEALEHPWFGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD64</accession>
    <name>A0A317XD64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_530263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472298.1">
        <property type="nucleotide sequence ID" value="XM_025610645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD64"/>
    <dbReference type="STRING" id="1450535.A0A317XD64"/>
    <dbReference type="GeneID" id="37112788"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF58">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="504" mass="54486" checksum="B9DDC7CC44008159" modified="2018-10-10" version="1">MSRPVPAVFRPIWRRNFSVSTTKRAIDKICPSAQEAIKDMKGSSTVLVGGFGFAGVPTTLIDAVRDRPEIKDLTVVSNNAGMPGVGLGQLLESKQISKMIASFIGENKVFEKMYLGGDLSLELTPQGTIAEKCAAGAAGVPAFYTPAAYGTIVQTGELPVRYNKDGSVAIKNEPKETREFNGKNYILEESIFGDYALVKVHKADKLGNCQFRKSMNNFNEAMAKNAKYTIVEADHIVEVGEIDPESIHLQGIYVNKVIQSTGEKKIEKLTFAKDPSEMLQAGSGEATARRERIVKRAAKEFKDGMYVNLGIGMPLIAPSYVSEGVEVVLQAENGILGLGGYPKPGEEDPDCINPGKETVTLGRGASVFGSQESFGMIRSGRIDLTMLGALQVSQYGDLANFMLPGKVKGMGGAMDLVSNPEKTKVVVTMEHTDKKGNPKILPECSFPLTGPRCVWKIITDLAVFEVSPTEGLTLVEYAEGVTVEEIRSKTAAPFKVSEDLKPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD84</accession>
    <name>A0A317XD84_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sarcosine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_481352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473250.1">
        <property type="nucleotide sequence ID" value="XM_025608854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD84"/>
    <dbReference type="STRING" id="1450535.A0A317XD84"/>
    <dbReference type="GeneID" id="37110997"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY96489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="435" mass="48091" checksum="69549EAD8383501B" modified="2018-10-10" version="1">MVSTSKSDPIAIIGAGVFGLATALHLSSNGFTNISVFEKDTQIPARYSAGHDINKIVRAEYEDPWYTELALQAIEGWKTPLYAPHYHQTGFLHLVSGSAPEKASQTMNRFLSSIRTHPTYKGKLSTITTPTDIRNIAWQLTGPLPGWNGYFNQLAGYAHSANALRAVYEACAARGVKFFLGDQIGKVTELIYDNTNKKQVTGVRTGNGQIHSCRLAVVAIGAAAATLIPEVGSQVVAKSWSLGHVKLTDDETSMLRGIPVTYARDLGFFFEPDPKTNLLKICPMGGGYINTDPASGVSYPPATLQESENVLPAEDEKRMRRLLRETLPQLADRPFVEKKLCWFADTSDSDFIVDFVPETDGSVVLLSGDSGHLFKMLPIVGDWVYTLLRERKQGVDRWRWKGSAQKKGKWDGDVSWRLGETREFEEVRLIPGPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDI7</accession>
    <name>A0A317XDI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CipC-like antibiotic response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_541218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473156.1">
        <property type="nucleotide sequence ID" value="XM_025613038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDI7"/>
    <dbReference type="STRING" id="1450535.A0A317XDI7"/>
    <dbReference type="GeneID" id="37115181"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="132" mass="14962" checksum="31B4583BAD679054" modified="2018-10-10" version="1">MAWGWEQSDDAHREVYGEQQKHEGHLSHQVIAGAASFEAMKLFEDHQRKQGKTVSHSFAKEAIAGLVGAEIEKLAETKGMDEVDKMKAHHHAKKNAQEMYEHHYEQQHGAPEFDPGRFPPPDRFGPGGRGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDL5</accession>
    <name>A0A317XDL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_529811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473186.1">
        <property type="nucleotide sequence ID" value="XM_025610531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDL5"/>
    <dbReference type="GeneID" id="37112674"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="54" mass="6080" checksum="3EB84CAF09CB6BC3" modified="2018-10-10" version="1">MARKVVYVWLLRSISGPAIEDPVWLKSGSTVVQSFGNFARFGEILSKHGWVLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDU4</accession>
    <name>A0A317XDU4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_563265</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471461.1">
        <property type="nucleotide sequence ID" value="XM_025614350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDU4"/>
    <dbReference type="STRING" id="1450535.A0A317XDU4"/>
    <dbReference type="GeneID" id="37116493"/>
    <dbReference type="OrthoDB" id="190375at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000017">
        <property type="entry name" value="Synaptobrevin-like protein Sybl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="12"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="159"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY94700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="256" mass="28388" checksum="857B2035DDD61E4E" modified="2018-10-10" version="1">MAASSSKPASFLLYSCIAHRTTILAEHSSPGTSSTAASSLASIILPKISHDQPQKLTYTHERLFVHYIADSPTGTNTTDDSTRQEPNSYAPLSYIVVATAEQGRRIPFAFLLEIKRKFLSTYPPSSTDFSALPAYGCAAFNNELRSLLQTYNTAPPADSLASARREIDSVRNIMTENIERVLERGERIDLLVDKTDRLGGSAHDFRIRSRGLRRRMWWKNIKLMVLLAVVVVFLVYLFVGMGCGLPAWGKCVGQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDX7</accession>
    <name>A0A317XDX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_219338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471889.1">
        <property type="nucleotide sequence ID" value="XM_025606211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDX7"/>
    <dbReference type="GeneID" id="37108354"/>
    <dbReference type="OrthoDB" id="5352400at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="35310" checksum="27AC3462D49B7AA0" modified="2018-10-10" version="1">MRIQRIPPLREFFPTRWRNHNMMYIFMTVELPLTVIILTLTGIASHNLYRTKLWQDGADNGFNSSPTDRLYAAANHQPYTTPIVWSSFITEYNLVLGILSVFMWITKIPVHILHMLTPPLSAFIHAGMIAVWCYSARYQAGPDMSDPEHPQPGAPWYIAKKCSVAAHKEDIHYCEQAKALFVFSIIIIFYYFAVLCLSLRNCIMTKEEREEQAERDEERKTMKEFEEFVLQSPGLPRTASLRQPGPMPGKAPFHHMIPRSNDASSSDLPLRQHFSSPNPRRSMHQESAETLSGHRAQSQTSFVQTSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEE6</accession>
    <name>A0A317XEE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phenol acid carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_453292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472913.1">
        <property type="nucleotide sequence ID" value="XM_025607557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEE6"/>
    <dbReference type="GeneID" id="37109700"/>
    <dbReference type="OrthoDB" id="4415004at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008729">
        <property type="entry name" value="PA_de_COase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40087:SF1">
        <property type="entry name" value="PHENOLIC ACID DECARBOXYLASE PADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05870">
        <property type="entry name" value="PA_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="20207" checksum="E65CF3FE67750C3A" modified="2018-10-10" version="1">MPIHPPTATPTFNTDLLNRHLIYNYSAHDKAGNPETWRYEMWFYNEDRIVYAIHGGPMAGRKNFQTATYQCIRPGELWQCNWLEETGTICSLVYDIPNRKITTLLGFSRGHWVKNVEARGDKRNREDMERWRELARVGESQADRVLLSEQADVVEVFWGKGELEGIEMGWETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFF3</accession>
    <name>A0A317XFF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_482635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472559.1">
        <property type="nucleotide sequence ID" value="XM_025608898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFF3"/>
    <dbReference type="STRING" id="1450535.A0A317XFF3"/>
    <dbReference type="GeneID" id="37111041"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="84" mass="9469" checksum="720C090B496A4005" modified="2018-10-10" version="1">MADKLRTIQNLEAMQARYIGTGHADTTKYEWVSNIVRDSYASYIGHPPMLSYMAMGMGESKEKVRAQMIEKMVRGAGNPPETQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFI2</accession>
    <name>A0A317XFI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_138177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472609.1">
        <property type="nucleotide sequence ID" value="XM_025605708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFI2"/>
    <dbReference type="STRING" id="1450535.A0A317XFI2"/>
    <dbReference type="GeneID" id="37107851"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000005">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000004">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8 11" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="9">
        <location>
            <begin position="75"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY95848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="153" mass="16508" checksum="85D614D2AE2E5062" modified="2018-10-10" version="1">MAKKALPKDQIVKLIVGAGQASPSPPVGPALGSKGVKSMDFCKEFNARTAHINTGVPIPARVTVRPDRSFMFDLRTPTTTYLLLQAANIEPRKNRIRGAQNPGHETIGKISLKHVYEIAKIKHTETRLSGLSLQGLCKSVIASAKSMGIQVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFP5</accession>
    <name>A0A317XFP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic rRNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_570911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473398.1">
        <property type="nucleotide sequence ID" value="XM_025614845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFP5"/>
    <dbReference type="STRING" id="1450535.A0A317XFP5"/>
    <dbReference type="GeneID" id="37116988"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="341"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY96637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="366" mass="41416" checksum="FCD01CB209B6853B" modified="2018-10-10" version="1">MVKRSKLLQALDEHRGRDYEAEKQKKLVKAARKRKGDVKPVEEKKEEEKEENEEKEEKEEKEEKEESEEEEEEEETPDSDAEEAQEEEEDEEEEEEDIPLSDLSDDEREDVVTHQRLTINNSAAITSSLKRISFLSSATPFSEHNSLVSQEPIEVTDPNDDLNRELAFYKVCQAAATTARGLLKKEGVMFTRPGDYFAEMVKTDEHMGKIKKKLYDEAAAKKAAADARKQRDLKKFGKQVQVAKLQQRAKEKRETLDKINALKKKRKSDTSGPTEDKDNLFDVAIEDAAAQPSRKRGRDSENGPSMKRQKKNERFGFGGKKRFSKSGDAASSGDMRDFSVKKMKGGAKGGAKRPGKSRRAAAKGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGK3</accession>
    <name>A0A317XGK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_562595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472821.1">
        <property type="nucleotide sequence ID" value="XM_025614298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGK3"/>
    <dbReference type="STRING" id="1450535.A0A317XGK3"/>
    <dbReference type="GeneID" id="37116441"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="246" mass="27310" checksum="3D08538A173E667B" modified="2018-10-10" version="1">MAGKKLHDNVLRTKAPSVLGRSVFIGLRALDVFWQYHLLSQGWLTRAIERLDGFLPRPYYSVVLMLSLGSSVKQILAMLLVSEQETPVASAAMIATFNTVINTVNTLLSVWMATRPASTSKSSSLVTNPIIVAGLAAYTVGILTELVSELQRRSFKRNPANKGKPYSGGLFSLARQINYGGYTLWRAGYATITGGVAWGGFVFSFFFYDFATRGVPVLDEYLVKRYGEPYKKVKRRVKYSLIPGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UUG1</accession>
    <name>A0A317UUG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_356547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000064">
        <property type="protein sequence ID" value="PWY65016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461367.1">
        <property type="nucleotide sequence ID" value="XM_025607134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UUG1"/>
    <dbReference type="STRING" id="1450535.A0A317UUG1"/>
    <dbReference type="GeneID" id="37109277"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000260">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF17">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="4">
        <location>
            <begin position="472"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="3">
        <location>
            <begin position="610"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY65016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="805" mass="89939" checksum="C215938DDF923EA4" modified="2018-10-10" version="1">MHKTSPIDKRRKFNPDASLVLVGIRGCGKRSLGFVAATALKRRFITEDHYFKEMTGHTRHEFLKRFGSQEFQQRDIEILKSMLDNHRSCCVIECGLGSLTRPVQEHLRRYSATNPIVYLIRDMDRIQSLLGLEDQSVKLLCEGDPLHRTCSNFEFYNVEDCSSISAQTDEGSPDRRCVDYSFKLKEAKEDFTRFVRFVTGTDVGHTSYDSPFVLLETPPELRSFTHAVFVRSSDLAEGIVKLPELESGGDAIELCVDRWGPGLTATLSKQVALLRRNARTPIIISIDKSPTGIAKEDMSPAQVNSSYFAIVEHALRLAVEYLAVDLGQEHARVQEAIRTRGNTKIIGQRIFEPSALETWESEECFSLYLEAEKLGCQLVRFLRVATAREDNAAVLKFTNKVHALSGNHPPVIAYNIGSLGRTSQVFNSILTSVTHPAIERTTDNGRDPQITSRDAVQALFQSYVLDPLQFFILGGNVAYSLSPAMHNAAFRHCGMSHTYTIPESPSLAIMDRLGRDSHFGGSSVVQPWRVQLSHKLAAKSRHVEAIGAINTIVPLRARADGSMFPLQEQASRRNQAGPVLGWYGENTDWVGIMTCINRNLSPRNAISPSKTTGLVIGAGGMARAAVYAMLRLGCRKIFIYNRTLSRAESVALHFNSWAASQVESTEVVYVLKSLKDEWPADACPPCMIASCVPADRDGDEPPANFEMPMQWLGSPTGGVVLEFAYKPLDTPLLRQMRRIRSETGRPWVLVDGLDNVVEQAIPQFELMTGRKAPRRLMFSEALRNYEGDDGRFDEKTIQARLDHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVP5</accession>
    <name>A0A317UVP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_333655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461598.1">
        <property type="nucleotide sequence ID" value="XM_025607000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVP5"/>
    <dbReference type="GeneID" id="37109143"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY66143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16867" checksum="FFD15F1FE247544E" modified="2018-10-10" version="1">MCGDWKDFFARTARGTRGRLVMAVSIGTPYRPLPLRRHLTGRNHRNASLQLTTSLPNMVVTFHGRRMYFTRLMAFKSLRQGLPLYLLLTYLHSTGPGIGLDTRSWPADGLRPPTAQGIVKRLKFVQLHRPMRSHGAGNFPSRTNLVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZI0</accession>
    <name>A0A317UZI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_590994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461808.1">
        <property type="nucleotide sequence ID" value="XM_025616077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZI0"/>
    <dbReference type="GeneID" id="37118220"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016271796" evidence="1">
        <location>
            <begin position="16"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="107" mass="11412" checksum="B022D9A261EDD3AF" modified="2018-10-10" version="1">MIVTGVLMALSPGWLLPVIGPISPSIHSIGCQMTGTSSIPLDSIASHRITSHPIASPETSPPIKLFLAKPTLIFPSALGPSQERPTGIVFVVEEERADVRPGHVNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZP6</accession>
    <name>A0A317UZP6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_540644</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461622.1">
        <property type="nucleotide sequence ID" value="XM_025612959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZP6"/>
    <dbReference type="STRING" id="1450535.A0A317UZP6"/>
    <dbReference type="GeneID" id="37115102"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF163">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="40"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY66358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="521" mass="56732" checksum="474BB6C98C95DD21" modified="2018-10-10" version="1">MKTEDPEITAGGDANSPPSPDPPGNVVDPTRWPLWRKWSIVVCIALMYMLANFGTIIIVPGVPRILSDFHVSRDHLYEPLIVSIWELGEGVGSFLVGPLSEQYGRSVVYHGGNVLFILCSVAAALSVNIGMLVAFRFINGLAITTITLAPSITGDLFVREERGAAMALAITLPLIGPCAAPIVGGYVTSDLGWRWAIWIIAIAVGSVSLCSLIVMKETYRFKIAQDQPASPGGSPPREPKLQTLLRPMRLLFSSPVVLVTSLYTALTYGISYLILTTLSEIMHDIYNFSQGPVGLTFLGRAIGNLIGLAIYGLTSDRYLQHRRQKTGRSLPEDRLPLMLLGTILLPTGLFLYGWSSHSHIHWIVPLIGTGIVGASLILTRLPTENYLVDAFDPDGTSASVLAANATLSALFGALFPLAGPSLYRTLGVGWGNSLLAFISLAFLPLFTVLWIHGEILRREGWGYLWVIVEPWFQGTHQRGSGGLEGERYHAEDENSGDGTQQGRREGEKHAVRTHQQGVRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZS4</accession>
    <name>A0A317UZS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_570247</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461652.1">
        <property type="nucleotide sequence ID" value="XM_025614789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZS4"/>
    <dbReference type="STRING" id="1450535.A0A317UZS4"/>
    <dbReference type="GeneID" id="37116932"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000163">
        <property type="entry name" value="Multidrug resistance-associated protein member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="692"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="154"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="438"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="753"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY66388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1010" mass="109623" checksum="BE7F970764BFDC59" modified="2018-10-10" version="1">MKSIKAMGFPQNVQGKIQDARDMELTAARVIYWLDVLLAASASFLNALGPAITLGIYTIWAKLTGNALLDADGIFTSFALVQMVTLPANSILFALPGFFSALAGFDRIQSYLLEPIQEDDRIVLALETETSGSTPERDQHVAFESIDFGRVDAVSVEDLTVTYGNGSRPVLQNITFGIGIGSIVIITGPTGSGKTTLLRTIIGDLQPESGTALVTSGVMAYCAQSPWLGSGTIRDNVAGPPGSKVTDEDWYRRVIRACDLEYDLQKLPAGDRTIIGNGGTSLSGGQRQRVALARAIYSGLDILVLDDVFSALDARTAGRIANRLLGPAGLFRELGKTVILSTHTVNFLPFADEVIVLNNDGSIAEQGPWDQIKGQDRFSSLKPLEVFDISDDATEETNYPPFQPEEPPKAKTPSDLNRQTGNGAIYWHYIQAIGKTRVFATLLIMISSATFAVLIQTWLRWWSEDNDAGQRTWLHLAVYLALSLGHWSALASISTVSLLIVPTSGRNLHNQLLKTVVKAPLAFITSTDIGTTLSRFSQDMTQVDRRLPGQVAALGSQAFKLLAQVFLLFMAQTYMLITFPILALIVYAIQKIYLLTSRQLRWLSMEANALPSNNFLETVQGIATIRAFGWEDAYAAENSKAVDAAQLPSYTLFSIEQWLALVLDLIVAGVALLNVVLIVTLTDSFTAGDVGISMNVILTVNMVLLITVQSWANFDASLGVISRIMDFAKTVTPEPEPASPLVPPKSWPASGAVELRNVVADYDQPTEASALLEPHAHALDHISLKLSPGQTVGICGRTGSGKSSLFLSFVRLLELSEGSIIIDGLNLSSISRDVVRSRLITVPQDSFILASDTVRQNLDATGTATNDEILDALDKVHLSSTLENRAIDSGFTSTVFLDVPMKEWPLSQGQLQLFSLARALLLRRSRGKVILLDEATSSIDFETDALIQKVLREEFRGYTVLVVAHRLETIAEADSVVVLDQGCVAEVGDVRELLQRDGSVLRSLFGSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZY0</accession>
    <name>A0A317UZY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_540411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461963.1">
        <property type="nucleotide sequence ID" value="XM_025612911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZY0"/>
    <dbReference type="STRING" id="1450535.A0A317UZY0"/>
    <dbReference type="GeneID" id="37115054"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016292388" evidence="2">
        <location>
            <begin position="19"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY67614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="377" mass="40903" checksum="98C52AB5FDDA2981" modified="2018-10-10" version="1">MVTLTAFLLLEAASIVAGAPTQVSNDSSTSFLANAKAGVTTLQTWYNQSTGLWDTTGWWNSANCLTVLGDLTALDSSLLNSSAAIFNNTFLRAPISNLGQSVWKSNASKPLPPTGVIETQGFINEYYDDEAWWALGWIQAYDLTHDQRYLDTAADIFEDMTTGWNATCGGVWWDKSHTQNGAIENELFLSVAAHLGRRIPSNASYYRDWAMKEWTWFQNSGMINAENTINNGLDLTTCRNDNGTVWSYNQGVILGGLVELSKLVGNTSYISTAQKIADAAIQALSDSDGVLIESCEPDCTGDAPQFKGVFMRNLQALYQASPEDGIKEFLETNANSIWQNDQGKDSELGDSWSGPLSNADATTQSSACDALVAAASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2U0</accession>
    <name>A0A317V2U0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_611727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY67959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462008.1">
        <property type="nucleotide sequence ID" value="XM_025616642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2U0"/>
    <dbReference type="GeneID" id="37118785"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="93"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="263"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY67959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="434" mass="48388" checksum="A6EBE4C0BA4BBAD4" modified="2018-10-10" version="1">MTVKANNANGHIGQVKETVQAFVDGNVAISPNAPEEVPTLLKRLALHGEAYLTESDENERTKILDTARSLVYALETPREAIIRHCWSQSTLYAAIETGVDLGLFTVLSQDDKPKTATYLAAATGADPTMLARILKHLAAMGVIVETGPDKYRRTGFSISMGSPRYSDAYPCMTGCITDGVLALPAQLKKTNYRNPSDGKNCAFQRGFNTPLHFFDFLRENPAHAIQFNNHMSAYHQGRPSWMDVGFYPVLSLVSDTGINEEDTLLVDMGGSMGHDLSEFHRKWPQVPGRLILQDLPKVVDQARTMNLDPAIELMNHDFFTEQPIKGARAYYMHSVLHDWTDDDCRRILANVMPAMKPGYSKLLLNENVIPSTNAYWETTSLDIIMMADFASTERTEMQWRALVESAGLKITKIWTVRRGVESLIECELAVDVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V378</accession>
    <name>A0A317V378_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_540294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462121.1">
        <property type="nucleotide sequence ID" value="XM_025612887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V378"/>
    <dbReference type="GeneID" id="37115030"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY68099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="92" mass="10080" checksum="E0EFE879CCBEC433" modified="2018-10-10" version="1">MLPTSPETQSAPYPPKCRRFQLVAFALLPIIIIISSSGSENLGPGNANAIKTHYPQVKGSRLNVPRNHHDDRTSISRRYLCPNSIALTGTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5K9</accession>
    <name>A0A317V5K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4419 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_540244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462234.1">
        <property type="nucleotide sequence ID" value="XM_025612874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5K9"/>
    <dbReference type="STRING" id="1450535.A0A317V5K9"/>
    <dbReference type="GeneID" id="37115017"/>
    <dbReference type="OrthoDB" id="9978173at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY68571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40280" checksum="39D3AB7DFAE43D53" modified="2018-10-10" version="1">MPITLKTSNVPPEPWISTKADNAEQLFQQTCPKLFEKSDRILQSSFPELPRHITPDENGFVRAVWKAYSNHHHLVLRPDDIWFAILVQLSFYINANAETLRSQFVAHHDQKQLTVSAGGNIHTVNVGLLAIQMTNLIKQNVIDLELHAWIMPSFTTTTQSDEIVAAVLMMGTFQKYFDYTMVLLCGIPTVTLLGEREDWVALLAKLERIPSLGTQPARFAGLLKPILEKFVESFDQPDSPELFDFWNNCVHHESGSGVSSLSGWIIEFCFWNEDGDLIHRSPPSLDGWGVQAVSIDTDVIPSGMTSVPVLLNDNGNQLRTRMVAGLVGIEAMSGPDSNQSALDSIRPYSGWWMFEEGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V670</accession>
    <name>A0A317V670_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_528195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461999.1">
        <property type="nucleotide sequence ID" value="XM_025610412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V670"/>
    <dbReference type="STRING" id="1450535.A0A317V670"/>
    <dbReference type="GeneID" id="37112555"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="48"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="626" mass="71265" checksum="EE8A21B193592C0F" modified="2018-10-10" version="1">MSLKDEFPIRLDQIRLVTVCPPSDYQDDPVRCNLEVLDLAHETQNMQYTALSYTWGAPAEYGQFSTMTSELKCPIIRQGTVVRVAENLAHFLNRVQHTPSLLEKKFWIDSICIDQENDEERAHQVKLMSHIYSSANGVVTWMGEEDEYTGTAFKALKRIHELILDGTMDESPAYLRRGENRLGLDVSDGEAWRSVGKFFQRCYFNRSWTIQEVILGKEIEVICGGEKMNWEVLITSSRFFSQTGWKGFLDNLSVAYPEEIYVPAYYMTKQHWTTTLLYALQRSRDYKATDPRDKVFSMLGLVGKFIKDKPRLAPAYGTQSVTTTYTNVAIQLLEDGEDLYILSCVEGELFQRVGKLPSWVPDWTCGKSTGLLIIGYKRYSAAGTITQRPYIDSSALTVSLKGAKIDEVTLVGEAKHEVLDGLPFLGWLEIVASLPQWYRDIPEEAGGESRLEVFWRTLLRNTTGRPPILIPTQDQGLHHAFETWLRDKTRDRPKGMTDAKWESMSKALLELLGPDDIVPISDLTDTIGFHTRLSWAKHLRLFRTRTGYLGLGSECVQEGDSVWIIPSSRVPLILRPVDNMDKTRQRYRLVGGTYLHGVMHGEMVCPCCSVPGQGDIESRWETILIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6F2</accession>
    <name>A0A317V6F2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_478371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462180.1">
        <property type="nucleotide sequence ID" value="XM_025608686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6F2"/>
    <dbReference type="STRING" id="1450535.A0A317V6F2"/>
    <dbReference type="GeneID" id="37110829"/>
    <dbReference type="OrthoDB" id="9978173at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY68517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="359" mass="41064" checksum="63415B3F3541471D" modified="2018-10-10" version="1">MPITLTFPGIPPHGWNGKPGAANGLEFFGQTNFGDTVETTEIINSTFDNVDFEARRLIGWKHGFLEALYNAYCNHHQLTIRPEDIWFSILSQLNLYVNAHPQESRHLFVRPSQRMPPIHPESTVSALANYMEAALAHHVNDPEVRAWALPSFSTTTEDDAVTASTLVMGAITQCFQFPCPYIWPRGIQSLTLLGERTDWEALLTRLEMIETWGEQPRRFATNLRPVLRRFVTSFDGNLRKCHYFWNWCFREKREAGMTMIVAGWATAFCFWDVDGECIPPVINPEERVVEFDGVSYPPLQMSTFPGSYATFKTFCIDEEGIRRRVRFVAGLVGFEVLYHPDGFDGGWTELQPVSGWWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V706</accession>
    <name>A0A317V706_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_300603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462356.1">
        <property type="nucleotide sequence ID" value="XM_025606742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V706"/>
    <dbReference type="STRING" id="1450535.A0A317V706"/>
    <dbReference type="GeneID" id="37108885"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="43"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY69041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="336" mass="37042" checksum="97A008BD013A4289" modified="2018-10-10" version="1">MSLDQVSDSGTSGDFEHPNQNLRRSVIIALYFAFILSTVAVALRLLARKITGSKLYLDDYLIIIALLFKYGCSIGVTILLFNGLGSHITMIPQKNLTVYFKIGWSNSFVYTCCVAFIKLSILAVYKRLFAAKSMTISVNIVGTIVILWALSVSIAGVLNCVPVHKFWDRTVPGHCVDTVSYYYGQQIPNILTDVVLLVMPLKSVWALPISKAQRLLLSGVFLVGILTLCFDIVRLVAMIQLTQAGPDITYNQVPVVVWTCMEAAVGITAACLSHIRPLFNVKLWTRLRTSSQEPEKRQLNSATSEAFSTDRTLFDPCGTQTTIYSGHEACVEAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V834</accession>
    <name>A0A317V834_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TRP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_590477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462383.1">
        <property type="nucleotide sequence ID" value="XM_025616030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V834"/>
    <dbReference type="STRING" id="1450535.A0A317V834"/>
    <dbReference type="GeneID" id="37118173"/>
    <dbReference type="OrthoDB" id="2115177at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF5">
        <property type="entry name" value="DUF907 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G06100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016282086" evidence="9">
        <location>
            <begin position="26"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="584"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="27"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="655"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="668"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="694"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY69178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="733" mass="79949" checksum="3618CFEB9BBE80A1" modified="2018-10-10" version="1">MVNMRAIPSLPTLIALGLFAPRVLAADTLSTQGLTTCLSDSAIQVDKLDVTYTRSTREIVFDVAGTNAKEQNVTAALTIYAYGSQIYSESFDPCSSEYYVEQLCPVAAGSFSAIGTQTLPESFASEVPSIAFAIPDLDGQVKLQLKSKTDNDELACIQSDLTNGNTMQIAGVSYAAAGVAGAALAVSGLSALGAVGHPGAAGSSSPNFGDVVTWFHTMATNGMLSVSYPTVYRSFSKNFAFSTGLISWGKMQEAIDNFRQSTGGNLTDNNYQYLLNATLVYSGDSSSNFSSNSKRGLNLVVGAVNVAAREVSTSYSNNTTSTNSTTASDDSDSFEHFVSGIEAYVEQLTVPQANTFMTVLLIFAILIAAITVGILLLKVILEVWALYGSFPQKLTNFRKDYWGLLGRTITNLILLLYGVWVIWCVYQLSGGDSWAAKLLAAVALTVFTGVLLFFGLRIAFLARKYKQSEGDASHLYDDHETWRKYSLFYDNYKKDYWWAFVPAIVYMFAKGCVIAAADGHGLVQSAGQLIVEALMLTLLLWNRPYVAKSSQWINITVQVVRVLSIACVLIFVDELGLSETTKTVTGIVLIAIQSGLSGVLAILIATNAIILCIRENPHAKRKREANKMNRDIDDLTPLDARESLLMEHPPRKEYSEMSNFNFTGPYEPYRDQHDSKSRQSTGSTERLVDPGYPLDDRHGRSISRESRRSHESHGSHDSPEGRHATTPGYGFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V890</accession>
    <name>A0A317V890_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_293810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462427.1">
        <property type="nucleotide sequence ID" value="XM_025606701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V890"/>
    <dbReference type="STRING" id="1450535.A0A317V890"/>
    <dbReference type="GeneID" id="37108844"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029167">
        <property type="entry name" value="Mug117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15474">
        <property type="entry name" value="MU117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="102" mass="10169" checksum="E16DB69AB4F9C62A" modified="2018-10-10" version="1">MNAGFGCGVFVEGKKCQMTGAELAAHYDHIMQFTGGGCKKCGQALLSNGCKVTVNYVGHCQNTDGILNLVGGDDESDGIPVGSGSGSGSSSALAATSHGLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8J2</accession>
    <name>A0A317V8J2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Ubiquitin-like modifier-activating enzyme ATG7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Autophagy-related protein 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_540018</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462367.1">
        <property type="nucleotide sequence ID" value="XM_025612824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8J2"/>
    <dbReference type="STRING" id="1450535.A0A317V8J2"/>
    <dbReference type="GeneID" id="37114967"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.70:FF:000001">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme atg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000243">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.100">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.70">
        <property type="entry name" value="Ubiquitin-like modifier-activating enzyme ATG7 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006285">
        <property type="entry name" value="Atg7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032197">
        <property type="entry name" value="Atg7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042522">
        <property type="entry name" value="Atg7_N_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042523">
        <property type="entry name" value="Atg7_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01381">
        <property type="entry name" value="E1_like_apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16420">
        <property type="entry name" value="ATG7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like modifier-activating enzyme Atg7 N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="10">
        <location>
            <begin position="375"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="695"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="697"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606285-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY69162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="714" mass="79260" checksum="3B00E359114E149D" modified="2018-10-10" version="1">MRYTPFASDIEFPFYTALASLKINHDKLDDAARKVLGFYEVRTTDPPNASCRMQIHGSALTNDETPAGLYRAEGMIKNVNTFEEYTNIDKAHILQRSAKMIWDAISDGTIYSTPSLLASFIILSYADLKKYKFHYWFAFPALHSNPSWTFSKDTERDDTSGLSRKATASDIPLSDAEIARLVETVKTWTHGVEDRQRGFFLARRVHDIKDGAGSENRSGITDQITESSNPDGPRWRIATLSAYENGFFNEASFEDCYVSFADPSNYDDAPGWMLRNLLVLVKRRWGLNKVQVLRYRDTQPQPSRSNYKSTVLILGSDTPSDGNSQIPSKDMPKVTGWERNPAGKLTSRLVNLTEYLDPKRLADQSVDLNLKLMKWRISPNLNLERIKHTKCLLLGAGTLGSYVARNLMGWGVSQITFVDNGSVSFSNPVRQPLYNFADCLDGGVKKALRASQALLEIYPGVDSTGHVLSVPMLGHPVIDVDKARAEFEVLQTLINEHDVIFLLMDTREARWLPTVMGKAAGKLVMNAALGFDSYVVMRHGIKTDEDPSAELGCYFCNDVVAPMNSVKDQTLDQQCTVTRPGVAAIASALLVELLVSLLQHPLGTAAPAPSSRSDDRGDHPLGLVPHQIRGFLATFENVPVVGRSYKYCSACSDNIILTYKEHGWGFVLRALNEPGYVEELSGLKEVQAVAEASLADVEWDEDSDSGEEIESSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBE5</accession>
    <name>A0A317VBE5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CoaE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_526759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462609.1">
        <property type="nucleotide sequence ID" value="XM_025610362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBE5"/>
    <dbReference type="STRING" id="1450535.A0A317VBE5"/>
    <dbReference type="GeneID" id="37112505"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001227">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY70318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="277" mass="31151" checksum="255B70358FF3E9AF" modified="2018-10-10" version="1">MLIIGLTGSIATGKSTVSSLLSSAPYQLPIIDTDLLARKVVEPGTPGYKAIVDYFGPTTPDLLLPPPPNDLPTSTSSSKSPNRPLNRPALGRRIFGTDPSRTRDREVLNKIVHPAIRREIYKSILYYYVRGHWAVVLDVPLLFESGMDLMCGVVMVVGVRDARVQMERLRARDAHLSETEAEDRVRSQGDVSGKVERAEWRGEGRGVVVWNDGDKRDLEGEVRRAMEGITVGRWWTWVLWMVPPVAVVVAGWNLGRNFWLKKGWEGRERERGRKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFW7</accession>
    <name>A0A317VFW7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Zinc/cadmium resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_525951</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463048.1">
        <property type="nucleotide sequence ID" value="XM_025610335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFW7"/>
    <dbReference type="STRING" id="1450535.A0A317VFW7"/>
    <dbReference type="GeneID" id="37112478"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000021">
        <property type="entry name" value="Solute carrier family 30 (Zinc transporter), member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000026">
        <property type="entry name" value="Zinc/cadmium resistance protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820">
        <property type="entry name" value="FI23527P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45820:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 63C, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="10"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="313"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="391"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="159"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY71812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="533" mass="58152" checksum="C443EFC87255B40B" modified="2018-10-10" version="1">MGLSKTNRILILLAIDTAFFLLELIAGYSVHSLALVADSFHMLNDVLSLCVGLWAVKVANRETNSKMYTYGWQRAETLGALVNGVFLVALCLSIFLEAIQRLVEPQEVKNPKFVCIVGCLGLLSNIIGLVLFHDHSHGHGHSHGHGDLEEGSDIEHEHAADHDHDHDHVHADGQGNNISLTKPIKHAEPSSPYSRRRRTLDSQHRGSRRYSGATARGYVDVEDIQVHPASLRQEIIAASRNRYDDEQSGSDSDLQEGAGNHPSERSALLGHSDRTGKYTDDAEVPARGRNTAGDDDLHKSHNHAQPKPRDQGHGHGHGHDLNMRGVFLHVMGDALGNIGVIVSALIIWLTDYSWRFYVDPGISLVITVIILLSAIPLCKAASRILLQAVPHGLSIDHIKEDIERLPGVIGSHHLHVWQLSDTKIVASIHIQVDTEIKGEGSERYMRLARQVRKCLHAYGIHSSTIQPEFAPDSDAEDTLTAPSYARAGSIGPSTSGTLPSRTPSVPDGDSQACLLECGEECARGGQCCPKKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VI77</accession>
    <name>A0A317VI77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_242178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463434.1">
        <property type="nucleotide sequence ID" value="XM_025606376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VI77"/>
    <dbReference type="GeneID" id="37108519"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY73169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="175" mass="19575" checksum="89B694E5EEDE9449" modified="2018-10-10" version="1">MYHLLFTIISLYTSTSPVLKKDIAPSHMLGTLEGKNPNQQPPAPSMGPWLGGFSLFRLPGMTSGGALFPRNRVTAVAANRWRKQRMGQIEFPRSRLLLRQVGPLARSLGGRRRRAPKRCAHFSWFGPYTEDYDRAEYDGREGREEPGKAQANGRQKRVGGVVARIGRLAWLGVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIZ7</accession>
    <name>A0A317VIZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_241531</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463422.1">
        <property type="nucleotide sequence ID" value="XM_025606371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIZ7"/>
    <dbReference type="STRING" id="1450535.A0A317VIZ7"/>
    <dbReference type="GeneID" id="37108514"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF4">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_4G09540)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="83"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="228" mass="26585" checksum="15A15EE0A39DFE7E" modified="2018-10-10" version="1">MAIEVVSLTEANIPEAIEIIQTAFAEDPYFEWVFDSCNFNKQRNSDSLAVRCLWGINNAIFQVARETDATGESRIVGVSCWLPPHSPHEPESWYSWYQGWVLSWRQMLNNVWHWGRGGLKTNRYWIWKDRQHEAQSQIWDDPKGYYFCNIVAVRPGVQGQGIGRKLFEAVTDRADQEGVKCYLESSRNVPNVQIYEKMGFAMKKEMECRDGEDVCMLYCMVREPKSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJY7</accession>
    <name>A0A317VJY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_559775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463531.1">
        <property type="nucleotide sequence ID" value="XM_025614098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJY7"/>
    <dbReference type="STRING" id="1450535.A0A317VJY7"/>
    <dbReference type="GeneID" id="37116241"/>
    <dbReference type="OrthoDB" id="4469984at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY73779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="263" mass="30279" checksum="7EE875221379D514" modified="2018-10-10" version="1">MSGKSISNLPCDDPQCFCHLRPPKPFPKIEAVLSGSEPDQVRELHQPNAQLDVAFDVVGNTMTLNECVFDPSRPKIAYSVGLIIKAANVHFLNLEGLPDHSLLLSLRIRRSACAVRGNKMILKEKFNGYFPDPPYSRLFNDLFECRWPDKTLQIRLPEERCRRWKTVALILKTFKQITPDSYCHMANMMFTPRVGGLDVRQTKKDIKAQLEKANHERRKNPVSSEYMVTVNDEEKIERINHAYEVHLLAFIYSSSPFTPPQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLS7</accession>
    <name>A0A317VLS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_607001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463712.1">
        <property type="nucleotide sequence ID" value="XM_025616535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLS7"/>
    <dbReference type="STRING" id="1450535.A0A317VLS7"/>
    <dbReference type="GeneID" id="37118678"/>
    <dbReference type="OrthoDB" id="3796612at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY74519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="300" mass="33562" checksum="228F19CB67782EE8" modified="2018-10-10" version="1">MDDICEYDSRSSLVNAGQDNQSDDGERVASLEDASFGISLVPVGCASGYHLLNDARSPDQREMITAYDGSVYYEGKALEVIHGNLSPESNAFATLLVYEFRFTGRRPKARITWASVSFKFRNSDSNSPELKVLQFSPDHQGPLSPVEQEYESSTTLKWHAKAGISVVSGGGAYDKSNVVRCTKTKDTKVVGTPIITPFQRVYGVKWTLEENEASQAGVPDRIRTAILLERYTEDRFEATVEINMNVKNCYWMERLGGMKDQNDPILYNPSTPPTNHLGRVYDRHHLAAVDLSSFYKLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQ00</accession>
    <name>A0A317VQ00_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_425418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464257.1">
        <property type="nucleotide sequence ID" value="XM_025607439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQ00"/>
    <dbReference type="STRING" id="1450535.A0A317VQ00"/>
    <dbReference type="GeneID" id="37109582"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY76444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="117" mass="13355" checksum="356494FBA67FD9C8" modified="2018-10-10" version="1" fragment="single">MAITLSVLVFRAEPFDCIEFRHTSIYLDYGDGTQSTLHIVGASRDYHFEEVEKDHAESGKLERHILVTTFHEGFTSAMIKDACSNTRVNNDGSEWNCHHWVGDVLAELMKLEILIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQ62</accession>
    <name>A0A317VQ62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_577868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464072.1">
        <property type="nucleotide sequence ID" value="XM_025615190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQ62"/>
    <dbReference type="STRING" id="1450535.A0A317VQ62"/>
    <dbReference type="GeneID" id="37117333"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="74"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY76075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="38188" checksum="5B4D14C771574C53" modified="2018-10-10" version="1">MFFFSRVLPMGPLIWQAVLDICRPRFLPFQRLMHGLTATGGRLPYHDEAHPQSSYTDTQHHVITTKHRPIIQQSNNQKLIMIGIFAEVYLVDGTIIRKAPRSGSEEDLQPIIREATIYNLLDDHPRIAQCTSRGRMDYIDIKYYSHGDLASFCQTNEVTPELKSKLFQQLIEAVAVIHSYDIIHSDLALRQFFVDNDFNIRLGDFNSSQYPGHPALGYEKATHCLPRDYELPNTVLSDLFALGSTLYELLTGKPPYSNLYPVESEDTVRSGDPDVIRARFQREHLANLEVEQRYKNHEFPDVCHLFRGDIILGLWNGKITSAAEAVTLSTHSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VST9</accession>
    <name>A0A317VST9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_473940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY75992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463989.1">
        <property type="nucleotide sequence ID" value="XM_025608498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VST9"/>
    <dbReference type="GeneID" id="37110641"/>
    <dbReference type="OrthoDB" id="4381838at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY75992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="38069" checksum="F8B9EE48E6792DF3" modified="2018-10-10" version="1">MSTSDLSWSECPSGLYALPPFCYICGSHSIGMPMDHAPLNGMSKNEHALFYSASEMEKIYSLNYAGWRTLYRMILYDPQEQLYCLSGIAQNALASPLQRIEYMAPWDEDDWVLNNRRKEGFANPRVILPSENIEAQTSLAGYLMHALCWRHLLRFINGPTSADDLRILSQTLIQHWVKGGVHESLSLPISRCNFNPDPLGINTIRKLVTECRKRAAMGVRIKRTALTTQCRLHTLPMELQYMIMDLLDCHDVCAMLRGINWDVGTGYWKHRLHRLSFDEIKSIQDEELDWRWLCLRLELLESSPTGGERRRFFEVLRGIGAQYDAAREEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTK0</accession>
    <name>A0A317VTK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_538582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463887.1">
        <property type="nucleotide sequence ID" value="XM_025612523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTK0"/>
    <dbReference type="STRING" id="1450535.A0A317VTK0"/>
    <dbReference type="GeneID" id="37114666"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF53">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY75260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="668" mass="74842" checksum="10D963BC2F438F3F" modified="2018-10-10" version="1">MSAPRRNGQLSSCEPCRKSKLRCDHSAPVCNRCVRRGRSDLCVYHPAPLTRPREGPRFKATKNDSNGTLMPAKTLAWESLSISPASSSSISVLGSAQFPNPTKLPFSGTGFLGPTNWSGAFDDNAEPDPVDHSAPKSTPIDPQQVARGAQVLFLLENLSLYVEVMEKRFAIAPGWVLGPPLMREVFKVLGDIYRNATQNATNKYAHLMDLSREFFRNTLTPIETHPSMRLSEYFATVTPRWEVLSLLFALTGTSTYQVPPHSLGLEETDDVTSKEGLRQICIQASETCLQFCNHLGTLSDPLAWALIQHTVFLCCMHGSSDHRPWQMLGEITTTVFALGLHQPGTDTKTPFFLSEVRKRTMVGAYAIDKELATFLGRPPRICWRYCNIQYPLDMTYDEIVAEPEVREAATQRLDSAGWNIDGSLDKGVRVRANLIASIDQENVLEVSLSNQVDGLEEKVQKTRRKSDELRRSLPSYLQWTEENDHPAVASLHLEFLYHEFLLLQTLFKRTGKGNDSLIAKASEIVTILLHMVSMETRAGRIHPSIVWDLCYNGLPAAGVLCTELLRRSQPQSNLFQTSTTPFPRSDIIQKLSVFVAQLKTFVRQEEGNYKICLKGQKVISQALDRVLSPAPVVVDSMPVGNALEEDVDFMAFLENFDWEQEMRLTFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVJ9</accession>
    <name>A0A317VVJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Microtubule binding protein HOOK3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_626456</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464723.1">
        <property type="nucleotide sequence ID" value="XM_025617358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVJ9"/>
    <dbReference type="STRING" id="1450535.A0A317VVJ9"/>
    <dbReference type="GeneID" id="37119501"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="6">
        <location>
            <begin position="88"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="269"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="676"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="824"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY78414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="915" mass="104385" checksum="85A308A96528B234" modified="2018-10-10" version="1">MRVAWIPPPTPRRRSKKGSHQGPVLPPPSSFNFTVLRGRQFAPPGRDPNPPCAHSQPFLQFATAVSPAQSTAPDFSQPPTMAAEHTVTQALLEWINSFALGKTIRTTEELSDGTIIWEILQDIDPQYFLDEIPQRAPSDHWLSKWQNLKHIHKLLVNYIRQQPDGMPSGLDPNPNLELVAEKNSVKEANKLLKLLLIAAIRSPNAQTYVETLQSLSTPTQENLKNIFEEAQNGQHEAIDGEDDIKEDRELPVDLELQFEERVGKVLAENNRMAREKKDMQKQIDDMHDRLARLQENNDTLQSRLASTEDRLVNLRSGKGDLGLNAKALESKSRQQEDIIATQEARLATAQDEIDSLRMTVESLRVKNQRFQKLQDDYDELKTERDQLARKANAAEKYRQKLQASQDFEKENQSLRNQIKDFQQQLKEADSQQKWNSEREVELEEYRRVLPRIEQECSEIQNLKKQLEFNNHALTERLSNADEQRERDDALISELRERVRELEGSPGSPSLTPGTETPKLEGTLQKDFEAIGVKESQLKSENEELKKEVESLKGPSIGSPLEGFSEAFSETLQQARANSSQSDEYWKLYDQYTSALKKLAEAQEALDVSKRSLNDALAEVELSNKENVDLITEIKTNNSSELTKAREGEDDAMRRVYSLQAELDSTQALVQVTCAERDDLRNLLEKKQAEFRAEDQEAAEEMKKLLAELTAQENGDDPETAQKSAVELTRQVAVQIEKNLERLAKRAEVSYKKPHRLVVCVGTSQIRPNRFGSFGGERKRLDLLADRPFGDSTQMLAAKAPSLSRLGRFIAKRPSKLTPIIVQYIHQQNEHIKFLQERLRQLEEDTDEGISKERELELQKIIDAQARELTLMSSSWYELQNRLQNNNIGMSRYRNGLLADAQKGWLARQRSVVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW76</accession>
    <name>A0A317VW76_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransferase enzyme family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_568255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464464.1">
        <property type="nucleotide sequence ID" value="XM_025614668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW76"/>
    <dbReference type="STRING" id="1450535.A0A317VW76"/>
    <dbReference type="GeneID" id="37116811"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="349"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY77277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="585" mass="67057" checksum="704A37BCEFBB3D89" modified="2018-10-10" version="1">MATDGDPSLLEDVVKLLEKLPSIIEDVRHSELWTIDLGGDDDKNTEIVVRKFLEQHSILPLLQWRRDAIPRSYLKKATEILTQSGLQYIMRVGDKHVMWVMVDENTIRSLSLLYEEFLRNRGLTRVGIAALENLTSVLLTARDEQDSDAHLKATCVVQFRPSYTPDIRSRGRSLRENIRDNFAKHVLRIQRYYPGLIGAIYVVRPSYDYLANMDIPENLLRNTTILQRARDLAGHLGADIPPEYGGTGMTLSECDCLKNMYGEPIDEPAIQEALQKHPLSMKSGSGLDEKNEETASFPVQETTHDTKAAKPEPEPALDKSALFPERLGPRHVRVDSNTIVKYGPGVRLAEAEAMHLVSTHTSIPIPKLFSAYSLYGTCYIIMSDEKGEPFSKYWDRNSERKRQNILGQLQDYVAQMRSMKGDFIGGINLSPCKGSIFIASSFEYDDEDYSYGPYASEEQFTEGIVQALQDRLPSHLLDEPADPDSNFWNTEYTIYQTVRQLPTMGHTIVFTHGDLHPGNMLVRSDGTVVILHWDHAGYWPDYWEYYRAMSARTWRRSWDRMVEEFVPPFYIEYAILRRVFITIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYR4</accession>
    <name>A0A317VYR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mating-type HMG-box protein MAT1-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_521655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464985.1">
        <property type="nucleotide sequence ID" value="XM_025610158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYR4"/>
    <dbReference type="STRING" id="1450535.A0A317VYR4"/>
    <dbReference type="GeneID" id="37112301"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="222"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY79413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="338" mass="37985" checksum="1A868013C7950D4A" modified="2018-10-10" version="1">MNSIPLALNHTTESSDKLTELLWQDALRHLGSTNNEVLLPINVIDMIGQSNVDKIKSRLCALIGAPVVAFVDESINALRVMRTPAFSGTTISVASHEVASCLEFKSIKVPMKKHERSSVPVKAAKVPRPPNAFILYRQHHHPKLKEAHPNLSNNEISVILGKQWKAESEDIRVEFKALADELKRKHAEAHPDYQYTPRRPFEKKRRTLSRQYPKSTAEYKSPDLTTTSTETTSPSIDTNVQIDDTGIEGTMNFFPEYNMPIMHTGDILYNDLIPSDMPLLSDEHFQLDPEILGSLIAHVQTDFGKGTGLCTPPSTHISFTDRHIGETIEFSDYITDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYT8</accession>
    <name>A0A317VYT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_537911</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464639.1">
        <property type="nucleotide sequence ID" value="XM_025612379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYT8"/>
    <dbReference type="STRING" id="1450535.A0A317VYT8"/>
    <dbReference type="GeneID" id="37114522"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="14"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY78127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="384" mass="41754" checksum="A6EB91488E64BC33" modified="2018-10-10" version="1">MPDQFHGWVSHSPTTPLTFTTFTPKPFTPTDIEVQITHCGICGTDLHTLRSGWGPTDYPCVVGHEIIGIVTRIGSAVPTTPSTDTTSSPLQLGDRVGIGAQTLSCLQATCIACTSGRENYCPRMIATYNSRYLDLSGNNKSRTGPKTYGGFARTWRGPASFVFKIPDAIPSAAAAPLLCAGVTVFSPLRKYGAGPGKTVAVVGIGGLGHLGILFAKALGCDRVIGISRTGRKKQDVTEKMGADEFLATEEEKGWERRWARTVDVMICTVDGDDMPLGKYLRLLKVEGTFVLVGAPETPLPRIRAWELIGKGVTVTGSNVGSRDDVREMLRVAAEKGVVPWVERRPMEEVNGALRDMEAGRARFRYVLENKKEGERERKRGESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZ28</accession>
    <name>A0A317VZ28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA excision repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_497981</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464890.1">
        <property type="nucleotide sequence ID" value="XM_025609332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZ28"/>
    <dbReference type="STRING" id="1450535.A0A317VZ28"/>
    <dbReference type="GeneID" id="37111475"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029256">
        <property type="entry name" value="Heliccase-ass-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057931">
        <property type="entry name" value="RHH_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25806">
        <property type="entry name" value="RHH_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14773">
        <property type="entry name" value="VIGSSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="255"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="626"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="934"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="870"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="935"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1017" mass="115529" checksum="436D5071D9362138" modified="2018-10-10" version="1">MSSHWEVDNIDATTVGSDDDDDDLDGARPLVLQPTSLAVASSDHAPKSEDVTPRRPTTTTPFKQSSSPLDQKTPTVVDLLETDTGNESFNEGEAAYREFKNRKATKRKRSTANLKNRATKVTRVATANSFVGRLPTSDGKARPIRPLRDYGEEVSSEDELMEYTLPDYLQKRRSQFDRSTEHLKQSGLKLPPDYDNVEYSDDERLEFLEEKPAFENMTPCNPYKDITLPYSLGLIPAPIAQWLRQYQVDGAAFLHELFVYQKGGILGDDMGLGKTVQVIAFLTAAYGKTGDERDAKRMRKMRRSGQDQWYPRTLIVCPGTLLTNWMAELSRWGWWHFDTYHGDNKELALQAARSGRLEILITTYSTYLHNKDAVNMVDWDCVIADECHIIKERKSETTKAMNMINALCRIGLTGTAIQNKYEELWTLLNWTNPGKLGPVTVWKKTISEPLRIGQSHDATIHQLRKARGTAKKLVENLLPQFFLRRMKALIADQLPKKVDRVVFCPLTDTQADAYENLLGSDIISYIKHSTDLCDCGSRKKAGWCCRQFLSSGLTWRSYVFPAIAVLQKLSNHLAILIPQGADSNEKQEKDKDMLELAVPDQWEKLYRYRDSIVNYANPEFCGKWKVLRRLLKWWHANGDKVLVFSHSVRLLKMLQMLFHYTSYNVSYLDGSMSYEDRTKVVDEFNSDPRQFVFLISTRSGGVGLNITSANKVVIVDPNWNPSHDLQAQDRAYRIGQSRDVEVFRLISAGTIEEIVYARQIYKQQQANIGYNASSERRYFKGVQEKKDQKGELFGLDNMFEYKNHNILLRDIVNKTNVAESKAGVQVMDIDVDLNSSVPDPTSGKSDDTNEVMNQLAAMIRGEAESDTDSKPTLPTTPINTKHDPIQAILAGAGVEYTHLNNEVIGSSKVEERLSRHAQLADENTKNLDMQVFAGSQSQSQSQSHGKSSSLTTQPLKYKFHPPKAVMKRQFCSMAKRFGFPNATEFALVVEGMTQAQRRACLEQWYTERREKLIDTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2F3</accession>
    <name>A0A317W2F3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="12">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Sulfate adenylate transferase</fullName>
            <shortName evidence="12">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">MET3</name>
        <name evidence="16" type="ORF">BO94DRAFT_537478</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11 12">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2F3"/>
    <dbReference type="STRING" id="1450535.A0A317W2F3"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="4 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="15">
        <location>
            <begin position="4"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="14">
        <location>
            <begin position="174"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="13">
        <location>
            <begin position="395"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="12">
        <location>
            <begin position="395"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="434"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="12">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY79452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="574" mass="63890" checksum="EB660E453B1F036E" modified="2018-10-10" version="1">MANSPHGGVLKDLIARDAPRHDELAAEAESLPAIVLSERQLCDLELIMNGGFSPLEGFMNQKDFDGVCENCRLADGNVFSMPITLDASQQTIDDLKLQAGTRVTLRDFRDDRNLAILTIDDIYRADKQKEAKLVFGGDEEHPAIKYLNTKVQEFYIGGRVEAVNKLNHYDYVALRYTPAELRVHFDKLGWSRVVAFQTRNPMHRAHRELTVRAARARQANVLIHPVVGLTKPGDIDHFTRVRAYQALLPSYPNGMAVLGLLGLAMRMGGPREAIWHAIIRKNHGATHFIVGRDHAGPGKNSKGEEFYGPYDAQHAVEKYKDELGIEVVEFQQVTYLPDTDEYRPKDQVPAGTKTLDISGTELRNRLRTGAHIPEWFSYPEVVKILRESNPPRASQGFTIFLTGYQNSGKDAIARALQVTLNQQGGRSVTLLLGDTVRHELSSELGFSREDRHTNIQRIAFVAGELTRAGAAVIAAPIAPYEHSRKAAREAVAGSGGNFFLVHVATPLEYCEKTDKRGIYAKARRGEIKGFTGVDDPYETPANADLTVDVSKQSVRSIVHEIILMLEGEGYFDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2Y9</accession>
    <name>A0A317W2Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_548782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464869.1">
        <property type="nucleotide sequence ID" value="XM_025613417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2Y9"/>
    <dbReference type="GeneID" id="37115560"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="268" mass="30686" checksum="E55A9A83669D59EA" modified="2018-10-10" version="1">MAVAGRQRVQYTLHSTEYTLEEIGGPGGRKKQKFSYSRRQRAAKANLTQRKRDEPDVRYISFDNSRNYSGTTGEYTFPMYSEGLYRWDGKYVDTPTKFYILHTSHFAPSRGRSSDSALCSTYLVFPPVPYTAKLSYVYDLSQWYTGRSLRWWTRHGCQMVIGKMGAAPYLARTVQTLPIDLRDFVMESLEDNWINVVSGKDIHAGRQTFHTDATWPGRIETLPIDGYDARIGKRTKCRDNMTFSGKVAGAFSSPYGYTVTPYVEDNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W489</accession>
    <name>A0A317W489_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_587578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465437.1">
        <property type="nucleotide sequence ID" value="XM_025615835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W489"/>
    <dbReference type="STRING" id="1450535.A0A317W489"/>
    <dbReference type="GeneID" id="37117978"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="90" mass="10427" checksum="E257383D86D5F5F4" modified="2018-10-10" version="1">MMVQTTSDRVLGFDFDCAQTLLAHERKQIHVDWVEIEMHLVDDFTKGLAEDAKIGRIDATWTYYYQQKADLCEGNFQYLTNNFVASGEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W521</accession>
    <name>A0A317W521_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_496907</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465246.1">
        <property type="nucleotide sequence ID" value="XM_025609304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W521"/>
    <dbReference type="GeneID" id="37111447"/>
    <dbReference type="OrthoDB" id="8864979at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="53"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="421" mass="48512" checksum="01C84D2BEDD0E6EB" modified="2018-10-10" version="1">MSSFHNLVLQAKKARAVINYRGKKSDAKKNNPSKHAAGPSSVSSSVVNLVPTSSPWDLLPVEIQIKIFAHCGVTDFLPLRLVCKSFHQLLNSQEQWITRQYLRQRRHGTLPSPIDSERTYTRNPEDDAVLLSDLFPPAKSAKGGHIYTFKYISGLRRRQTLCSRLCCYIADRVMDRFVRNETAFMKSMFSAKAERYVFVQRTTARLWFHLTPLMYYSLYFLESYALARREQTNILLRDWEAGRLPVPVPPHIRKTMYRELQVKIIRSPPFTDTPTLIATHHCMQLLVSYLRYTVPPDEPTVSDDSWIGSLLTVSPFLRIVEYFSAEIGDGGNQRMQRKDFMHNFHNDITLHEKDDINALVFQNAPNVHLHGSVEDVWFDVVKEELASRKAAPHPAERVMVWTGLPVLFCCQDCRISDGWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W574</accession>
    <name>A0A317W574_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_587417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465782.1">
        <property type="nucleotide sequence ID" value="XM_025615825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W574"/>
    <dbReference type="GeneID" id="37117968"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016241941" description="Cytochrome P450" evidence="1">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7947" checksum="C0FBF017649400A1" modified="2018-10-10" version="1">MADNPTVAQSLVFLFYNLILHPAKAEYMYREDYGMDCAQPLQQLPFLNAVTKEKLRLDRAVLAFGYGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W599</accession>
    <name>A0A317W599_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Fungal-specific transcription factor domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_520669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465363.1">
        <property type="nucleotide sequence ID" value="XM_025610122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W599"/>
    <dbReference type="STRING" id="1450535.A0A317W599"/>
    <dbReference type="GeneID" id="37112265"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF74">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="190"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY80761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="532" mass="61251" checksum="7E8223C23F88AD78" modified="2018-10-10" version="1">MRLHSHGANYVGSVHWAAVLDSISELREHYEEEEARMLVSGHVLRPSPGPRLLYEPVHDTKADLLAAIPVRPVVDRMVARYFNAQGVIPEILHRGRFLREYEKFWQEPAATSLPWIGLLFTLMCITTQYQQSIEDSADPETLMRVNLFREKTIHCLVLSEYTRGGDYVLEALINYLTSEMFLSNDGEIGLWLVQGMLVQLALSLGYHRDPQNFTNITPFAGEMRRRVWAVIVQLDLRLSSEMALPRLLKLQHYDTTEPRNLLDTDFDEATVELPPSRPETEVTPVLYSLAKSRIDQMNGLVSDLVNDTGEHPYPEILNLDRKLQEAEASLPPIFRWQPLSQSFMVPPQIVMHRVLLQLAIQRQIIWLHRKYLTLTYCHTQYKFSRSACVQAAIKILEFQQIVDEETQRDGLLYPVRWMFMSSRLQAVFLLGISILCYYVQLTRTRPDVALDPETGLKMHNLLRSTYPLWLRSSAVSQEARRVVDHLGPLLGLNRTSELRLDGSTTVAPSQFDPPQDPMMPLDQLDWDSYEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5B6</accession>
    <name>A0A317W5B6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_558202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465383.1">
        <property type="nucleotide sequence ID" value="XM_025613989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5B6"/>
    <dbReference type="STRING" id="1450535.A0A317W5B6"/>
    <dbReference type="GeneID" id="37116132"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="94"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="581" mass="65955" checksum="7E07C0A3F8B8519A" modified="2018-10-10" version="1">MSVYYLNSSGGFELIPQEGLDEDLNLELGTSTGDETTWALIDRWISRCIQTHTACNNHVGKNFLPSRLLELETAGNERLFRVVERHQVEPGERYITLSHCWGGNPSNNALILRDDTFHSLSKYQPLSTLPKTFRDAFSIIERLNVRYLWIDRLCIFQDSRQDWQRESALMGEVYQNSLLSISALGSSNDDGGCFFPRDPAAVAPTIVNLCLDNPSNPQPYRFSLEKGWAWRLLFDPEPLPRRGWTLQERLLSPRVLHFGRKQVFWECRECACCEIHPNSVYVYGDEDEESASEPLSTAKHQHVWKQLLDAPDRLHSDDPIEQIYVDWYAILDTYSACRLTVPTDKLVAISGLAKGVKRRLAEIGCEDTYLAGVWRHELPRALNWNIQGSSRRPPSCRAPSWSWASVDGVVNMHARYCRDSQDSTTLLFVTVIDAECSQCTEDETGQVSGGTVTLKGPLATATLVPIHRRYVRLESLMAMQTLASIKVGDDEPVVKTPKENSYGESWEVIFDVKDEMCDEIYCLPIEGQHFDEDTWVVNGLALSRTSRDSYVRVGCVFLYVENEQAARDLFAGFSEVTCILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6C1</accession>
    <name>A0A317W6C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_150066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465389.1">
        <property type="nucleotide sequence ID" value="XM_025605794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6C1"/>
    <dbReference type="STRING" id="1450535.A0A317W6C1"/>
    <dbReference type="GeneID" id="37107937"/>
    <dbReference type="OrthoDB" id="2980193at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="409" mass="46835" checksum="5B41C0CDD77751A4" modified="2018-10-10" version="1">MHPRYPMDPEFFRDALRAAIRCHSADSVDVLLRRGGGNPDVYDLSKYERQQSEFLRFLPKSEDGIRHPPSGSRAELLAAMDENGYPAQTVHITEEEVEEGRWQDEFWTQSSRRVDPQQQNVIHPLILAAWQESTAVVNRLIAEPPRPSALAISSPVHEAIARGNNTMLRHLLARGFSPNTLPLGNVRESITPLMSTFLHRTNETWDEAAYDILAQDPRIDLDLRSPFMLVHILHFATAYSLTALKRVERDVPLSHADTTAYGRTLLYIACLPKLRQRFASKVRESIHALRCHYSSAPETKVECEAELGPQLKLIQYLLASGTQSVTAYDTDLNTPLHYLASARVINEEAIALLRAQPDGEVMWTEWRNWYGYTAEELYEKVHRKRKQKDSWYGGTTLRVAKMPKLRLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W741</accession>
    <name>A0A317W741_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_547970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465773.1">
        <property type="nucleotide sequence ID" value="XM_025613367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W741"/>
    <dbReference type="GeneID" id="37115510"/>
    <dbReference type="OrthoDB" id="3200925at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY81705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="103" mass="11982" checksum="BAAA027B2F754ED3" modified="2018-10-10" version="1">MTFTEHIVYWDVKPFDDWFEPSDAFTAQTGITHWAVSSESRSGIYRYILWIFLESGASGFGRDYRFVDESGDTYCLTCWTDGNHSLNYNSDKPNIVRVFAEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8Q0</accession>
    <name>A0A317W8Q0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_567273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465690.1">
        <property type="nucleotide sequence ID" value="XM_025614617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8Q0"/>
    <dbReference type="STRING" id="1450535.A0A317W8Q0"/>
    <dbReference type="GeneID" id="37116760"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13578">
        <property type="entry name" value="Methyltransf_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY81622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="263" mass="29022" checksum="8157780FE77E604C" modified="2018-10-10" version="1">MSESSWTEWSQNVISTLQDSVTSFLVSTENRADALRAYIAEHPSASFRDNPWALMAAIEDFATTKSHMMIFRESKMRIARAALEAMPVKPKVILEFGTYVGNSALAWGAILQSLHGADAAAQGCRVYTFEIDPGMVRVAREFIQLAGLDDVVHVLEGPAAESVKRLYEEGKIARGGVDMVFFDHWEKYYLPDLLLCEDLRVLREGSLVIADNTDMPGAPQYLKHVRSGGGGVLGMVRYESKAFESTTQIGVPNIVEISTVVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W920</accession>
    <name>A0A317W920_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">proline--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_536584</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465891.1">
        <property type="nucleotide sequence ID" value="XM_025612045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W920"/>
    <dbReference type="STRING" id="1450535.A0A317W920"/>
    <dbReference type="GeneID" id="37114188"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000066">
        <property type="entry name" value="Proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000125">
        <property type="entry name" value="Prolyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000035">
        <property type="entry name" value="Prolyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050062">
        <property type="entry name" value="Pro-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME PROTEIN L39/PROLYL-TRNA LIGASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42753:SF2">
        <property type="entry name" value="PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="87"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY83106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="635" mass="70857" checksum="B067216636067C3F" modified="2018-10-10" version="1">MITGFRPVPGRYSGIGRAYFGIARFHRTSKCAFHVDGRSRISNFWIPTGGISKKPVQGETEDANDLLIRGGFLRQAYSGIFHMLPLGLRVQDKLERLIDKHMRSLGASKVSLSSISAQELWEQSGRLKEGSEVFRFHDRKESRFLLAPTHEEEITTLVGHLTKSYRDLPVRVYQISRKYRDEQRPRQGLLRGREFIMKDLYTFDYNVENALKTYVSVKSAYTELFNELKIPYLVAAADSGNMGGSLSHEFHFASTKGEDTVISCSSCDSVYNEELADGKSHSIDEQQLQASHASGFDTGEASGESAKAVSVGLWMAISQDKNTLLRCWYPQYTLKDPNKPPVEREVNSHAVKSIAKAAGIDLDISIENPLKQWAAHLKSNEASGQRPRVLDVYDSHVRAYKRPPLTDTLDGVSRSVEDIDFSKLDRFPGTNNHLNLVRVHEGDQCSKCGQGLTETHKATELGHTFHLGTRYSEVLQASVVVDQAHLDKADRSPASQKDQIVPMQMGCHGIGVSRMISAVADSLADSKGLNWPRAIAPYEVIVVPAKGLEEEAETIYDVLTSEPTAALDVILDDRDKQMGWKLGDADLIGYPVIVVVGKGWKKQRTLEVQCRRLEVREDVAIEALPEFVRSLLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9W2</accession>
    <name>A0A317W9W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_567064</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465938.1">
        <property type="nucleotide sequence ID" value="XM_025614606.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W9W2"/>
    <dbReference type="GeneID" id="37116749"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="414"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="498"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="908"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="960"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1032"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1061"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1143"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="286"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="635"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="921"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1238"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY83153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1479" mass="163331" checksum="834BD8F2FF67F56F" modified="2018-10-10" version="1">MPSVVGMAALPSCQQVDNTLHIPPSSCRSGFDFSLLFEELILGILPLGIVLALAPFRLGHLFGRPRKVVASWLAWAKTAAWIALAIVHLVLTVLWALPSATRTDASIAANAVMTVGILLLCLFSYAEHNLSAQPSFLLNVYLGATVLFDIAKTRTLWLRHLEEINKAIAIITSVNVGVKVLLLLLEATEKRRILRQEYKSYPPEALAGIYNKSFFWWLNSLFYRGFSKVLRVDDLFVLDKQLESRRLYRILKGVWDGGKKEGENALFFACLKAFKWQISSVIPPRVMLAALNICQPLLLERSLSFSEQAVNKNTDNIGYGLIGAYILVYTGLGVTMGQYQHRTYRSITMVRGGVVSMIYEKACTLSTKDADPASSVTLMSADIERIVQGWQTMHDIWGNALEIGLAIYLLERQLGLSCVVPVVVAVVALVGSLIGMSFVMSRQAMWLEAIERRISSTSSMLASMKGIKMLGLQSALMKCVHNLRLDEMSISRNFRKLLVWNMALAWLTRIFAPVCAFGAFVGISHDQGNDAALNTSVVYTSLSLFSLLSDPLLSLVMALMTFAGSVGSFKRIQEFLQQEGHTDFRNKASAPPQYTLDEKTQMTVVNDTETSTDESKSFSSHSLKESLPSSNQNVVAIHNGAFGWDTTEEPLLKNLTITIPQGGFTILIGPSGCGKSTLLKALLGEVPCLNGDIEISLDSLSFCEQTPWHMNGTIRDCIIAMSDFDSQWYNSVIYACALAEDFEQLPRGDQTVIGSKGVALSGGQSQRIALARAVYARKEVIILDDVFSSLDATTEDHIFHHLIGNQGLLRSIDSTIIFASSSVKRAPYADHIVVLDNKGHLIEQGSFKALDSAGGYVSSFALGLPEWGYKADLFPASGMQVEVMKKPDKPETEIDADTRGKGGDLSIYLYYVQAIGWIPTIVFIVAIAGFAFCISFPSIWVKWWASSNEAEPGKHTGYYLGIYAMLGVIGMLCLMIGCWQMVITMVPKSGEVFHRKLLSTVLSAPMLFFSKTDSGAILNRFSQDLQLIDMELPIAAINTFATFTLCIAQMILMAIASKYAAISFPLVILIVYLIQKMYLRTSRQLRFLDLEEKAPLFSHFADCLSGLVTLRAFGWQRALQEKNDRLLDHSQRPFYLLYAIQRWLTLSLDMVVAGIAVLLIVLVVALRGSISAGYVGVALLNVIQFSQSIKLLITFWTNLETHIGSIQRVRSFTEDVPSEDLPTENHETPPDWPSQGGIEFKSLSAEYRSSEPVLSDVSLSIRSGEKVGICGRTGSGKTSLIMSMFRMVDISSGQIVIDGLDISKLPRREIRSRINGVSQSPLLMKGDVRTNADPTGCFSDEAIENALRSVGLYSKVQEKGGLEVDIDDLFLSHGQQQLFCLARAILRPGNILVLDEATSSVDTKTDEIMQRIIREKFSSHTILTVAHKLNTILDYDKVVVLDAGRIVECGNPHTLLTSDKSHFNKLYASLTMDEQEESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WC10</accession>
    <name>A0A317WC10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_496021</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465738.1">
        <property type="nucleotide sequence ID" value="XM_025609278.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WC10"/>
    <dbReference type="GeneID" id="37111421"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="958"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2428"/>
            <end position="2505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="958"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1110"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="990"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY81670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2513" mass="275824" checksum="3FA8C5C89E7E54CB" modified="2018-10-10" version="1">MPIAIVGMGFRGPGDATSVGRLWTMIVEGREAWSPIPTSRWNPSAFFHPDHARHGTIHVEGGHFLTEDISLFDAPFFNMTGDEVAAMDPQQRLLLEVTYEGLENAGIPLSRIMGSQTACFVGCFNADYTDLLLRDPDSIPMYQCTNAGQSRAMTANRISYFFDLKGPSVTIDTACSGSLVALHLACQSLRTGDASMAIAAGVNVILSHEFMSTMTMMKFLSPNGRCRTFDENADGYARGEAIGCLILKPLKEAVQDGDHIHAIIRGSGSNQDGRTPGITLPSGVAQEALIRRVYQMACLDPVDTDFVEAHGTGTQAGDPIETEALARVFGPGRTAERPLRIGSIKSNVGHLEGTSGVAGVIKAVLMLENRMFLPNRNFNTLNPRILLDEWKLKVQLECETWGTLGPHRVSVNSFGYGGSNAHVILEDAWGYMSDRGLIEIARPPVSCAVGNHIKPLEAHRTRVFLLSAFNEDSITAHTRRLRAYILEKGPGADDVFMSNLAYTLNERRTAHLYRVGVLGSSAADVAEALAGAAKVYKAPRRPNVGFVFTGQGAQWCGMGKGLMAAYPVFRQSIRRIDSYMARIHAPFRIADILEAREHAQLSHPVYSQPICSALQIALVDLLASWGIHPDSVTGHSSGEIAAAYTVGALNMEDAMAVAYYRGVTAGNLPTNNNRAKGTMLAFGMSADDAQPYIDQLQSGKATVACINSPNSVTISGDEAAIQELEELIRDKEVFSRRLAVEVAYHSHHMEPVSHEYLKYISHIKPRSESEIAQCLPNRSVAFFSSVTGTEFRPTELGPQYWIQNLLGQVKFSQSLRTLCFETRGNRNNPNPLGKRRSKRAGTARKVNVDFLVEIGPHAALSGPIKQIMKGDSRLDTADITYASALVRKHQAVVTILTMVATLACSGLPVDFRTINEPDPSYEPHLIVDLPSYPWNHSRSYWAEPRLSKVFRNRKYPRTDILGVQDIMSSPFEPRWRNIIRVSEIPWLMDHRIQSNIVYPAAGYIIMAIEAASQVASVNPGGTITGFYLRDILIRSALVLQETSAVEVIISLRLSGDDGSFQGPLYEFHVYSATEDDRWTEHCTGVVGVRSLCTRPSATTSESQMGIASDTCVLDVQAFYENLASAGLDYGPCFANITQASYTDAASLAEITIPDTAAVMPMNFQYPHLIHPCTLDGIIHSCFINTDMTGSPAIPVRIEEINIRASMENAAGNKLGVRTWITKETKGEIVASIAVAEKDKTIAASITGLHCRRIDQGSTNLQIARLAYRIEWKADPDMTSVESLSNLVKVFTMLNDEDLERERLYEDYALFYLRKAMIDLGDIHFEGISPFIKLYLESLECDGKRVLTRPISELHTESAELPGPEGKALCTMGHNLPAILQGQFGGPTVSNDQSLWDAYWESSLRDPVYESISKYLDLVSHKDPMVSILEIDAGTGLSSWRFLRQLAHSSNSPRCSRYIVTSPDETVFETAAQTLSIWKRWITFKKLDITEDLKFQGLGDLAYDVVIVPYGLHRVRSIQDALENIHSLLKPDGHLILVNSLQSPVDVILFADRGETWIDNRATYSNDDWDMSLKAARFSGITTLVESGGRRSMIISRPGHEHVPSPADILLITEDDNELSAHLQDMLLSTSLAVEVTSLQHANPVGKICIVLCDLNTSTLAHVHKEIFAAIKRIFLEASGVLWVTQGGTMLYSNPDVSLVTGFARTARSESAVRRIVTLELDRRDSSNTNDVAGVIYRVIERHFLMDEPTPIDDEYAARDGLLLLPRIIEDAALNRYLATSNDQYILKDEYFQHERPLQAIYDSASRPQKVRFVETIRPDLATDRVRIRVHAADLKQRDAQAVFSTATGHMLGSSCSGIVEAVGKEVHDFVPGDRAAGLGDGTVANVYEDRKTAFYKMPPDMSFESGAALPETYCSAFYAIHHLARIRASDKVLICLADSTIGEALLELICLQNAHVVLLVDTAADRGLLSTSYDIPKDQILFHGETIVANDNAQLSGVAGFDVIVNCDSSDNRTYQSLWKYINRSGRFLQLSDTQSMNGSNWALPRSPGDVMFASFSLDSVRNMGSDFVDQIWKQVGGLLRGGKLRGPVSPTTYAISEIDEALDALVSDQPADLIVLSAGPEDLVQVMQPKQSDTFLQSDASYMLVGGLGGIGRATALWMADHGARTLIFVNRSGLSHVQSQATVRELAEKGVRVFVHAVDISNSTQVEQMICELAHTAPPIRGVIQAAMVLRDIHIEKMTVEDYNAVLGPKHTGTWNLHHHLPKDLDWFIMLSSISGIIGNATQAAYAAGSTFMDLFAAYRNSLGLPTVSLDLGVITDVGYLAENTELASKMAKQGFQGTGTPTLMSLIEAAITSALDHPAGLEPFSSQIITGLGTWNPTHSLPNFDSPLFAHYRRLFIDPTEDTTTTDSSPDTIRDSLQCTKSLDEASSIIYSALSTRIASHLSIPIDRIDPNNPITEYGIDSHVAVDLRTWILKNIESAVSILEILSSGSLMDLAGRIAEKSALVKVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD48</accession>
    <name>A0A317WD48_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_557549</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466149.1">
        <property type="nucleotide sequence ID" value="XM_025613933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD48"/>
    <dbReference type="STRING" id="1450535.A0A317WD48"/>
    <dbReference type="GeneID" id="37116076"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000029">
        <property type="entry name" value="Mitochondrial intermediate peptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="288"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY83681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="796" mass="88574" checksum="F1386313FFF67174" modified="2018-10-10" version="1">MGALLLPLRRRPWTCRTCLLQARRSLETAASAAQRSAFDYFPSKNDAQKQSDDDTLRRVFDSQPFWREFSQRSAAQLKPTGLVQNQYLTSPDGFRTFATTTLQKCQAIVAKVLAGSTLEDHRNMARDLDRLSDLLCRVIDLSDFIRVIHPDPRVQEAATQAYALMFEYMNVLNTTTGLNDQLKKAAANPEVTARWSDEEKIVAQILIKDFSNSAIHMPPHARQRFVNLSNDISHLGNNFVNGAEPAKSHVVVSANSLRGLDPMLVQQIKRWNRTASVPTMGLIPRLALRSVHDESVRRDVYLATRTSSSRQVQRLEQLLAKRAELAQLSGYESFAHMTLSDKMAKTPEAVSNFLTSLVGSNRPYVQEELAQLQSMKGSVGRLQPWDHAYYVHQRVMQYSQSRRSRELSAVPEFFSLGTVMQGLSRLFDRLYGVRLVPQETAAGETWNADVRRLDVVDEADRHIAVIYCDLFSRPNKHPNPAHYTLRCAREISAEEVAECATTLDASAHPNDGMATAIDRTSKTLRQLPTIALVCDFPEPPATGAGRPSLLSEHSVRTLFHEMGHALHSILGQTRLQSISGTRCATDFAELPSVLMERFATAPEVLALYARHWQTDAPLSESMMRSMEQDRTAHGSIYGAMENESQILMALVDQAYHSLPAEKAAIDSTALYHQVSSAHSTLPDPADSKPPTSWQGFFGHLHGYGATYYSYIFDRAIANKLWEDVFQSGAAAVDRRAGERYKNEVLRWGGGRNGWGCVAGVLGSANPANADGRLVEGGDEAMREVGRWGLGRDGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD53</accession>
    <name>A0A317WD53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_566960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466323.1">
        <property type="nucleotide sequence ID" value="XM_025614596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD53"/>
    <dbReference type="STRING" id="1450535.A0A317WD53"/>
    <dbReference type="GeneID" id="37116739"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF812">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="8"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY83855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="335" mass="36870" checksum="B4DC985A95A47A3B" modified="2018-10-10" version="1">MAGITPLVFVTGATGFIGSHVVTTTLRAGYRVRLSIRKAEQEATLRELFPGYDYKIETCIVPDISQQESFKEALQGVDYVFHLASPTPGKGDDFKQDYVDPAVKGTEAILYAVLEFPQIKKVTVVSSVLALAPVGFLIAKDLVLADNTGEVIPVDISMQFPEGFAGHALKYAASKVLAHQATRSFLKDNQPHYTLINFHPTFVLGHSLIQKTAEQISGMNALFWLSVKSGKTRISNAWVHVSDVADAHVKALGTDIKSGTEFILSRPSVSWDHVADFIKTKYPAADCKLEPPFEGNWKLDTTAADTILKMHWRSEETIIEDVVEQQLDLIANVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDU3</accession>
    <name>A0A317WDU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_557732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466379.1">
        <property type="nucleotide sequence ID" value="XM_025613951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDU3"/>
    <dbReference type="STRING" id="1450535.A0A317WDU3"/>
    <dbReference type="GeneID" id="37116094"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY83911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="662" mass="74846" checksum="A6898DB17CA32C81" modified="2018-10-10" version="1">MMFLFQASQSPQESISRGPRPKRIKIRVACNVCKARKTKCDGARPICGPCSRRRRNSQACIYRESDGEAASGIREKTISRTEQSRYTSERPNDPPTDDDDRASLYSAIVPSGSLFGASGGVHLPEVNTESKQENTSRVLPRALKQLPHLEKQTPRKESDLQYAIPPRKVADTLLNLYWDYVDSAYPWLDRPAIEGAYETLWVKDGEPAMNERVLHCLLNLMFATSCVASQGQPPLSRDHSSAVFFARAQELMSYEVMEMYNFEIIQILLLTAVYQQHEKVPQKCFRNIGMAIHIAQELGLHIPGTTEAMENPKERDLARQVWNGCVILDRICSMTFGCALKIPQSVAKQGLNSLMLPPDTANTALPSKVNFYISFCRLHHIIGDVLETFYIVGDTKAEQNSSLFFDKFACLFRIDSALNEWARGLHPFFQMPSDAEDPTPTKHITREANVLRARYLSVRLLLFRLLLLQIHQQRPENLPGSGIGLYTDDQIMPHVVFQCQVNCTKAAADMIEFIGRNSPEQKQAYILPSNWYTVSYVYMAVTNLLAAQSSPQIVEYFSAARLRDVLQQAHDILKDYEKHPILASRCSSVIKLIEDYAPVEGSNVVMDHDHTPVQDLVVEGNDPQVIENLAMVENYSFDWNEWPMFFAQLDGDTPAGSWDIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE06</accession>
    <name>A0A317WE06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RCC1/BLIP-II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_557439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466569.1">
        <property type="nucleotide sequence ID" value="XM_025613928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE06"/>
    <dbReference type="STRING" id="1450535.A0A317WE06"/>
    <dbReference type="GeneID" id="37116071"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF5">
        <property type="entry name" value="RCC DOMAIN-CONTAINING PROTEIN ATS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="152"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="332" mass="34912" checksum="47EB87C423598AE3" modified="2018-10-10" version="1">MPLYAFGSNGSGQLGIGHIEDVSTPTKCLFEDTSPPLPASEITRIAAGGNHTLILFSDGRVYATGMNEDGRCGSLPGVDDAVTRFRQVVVDGVERFRDVSATWEASFLVSGEGRRVFVLGSGGRGSWGLEGGLFVVGIASGMGHTVVVLENGEVYGWGAARKGQLGQARKGDKVVWELVRIEEVGFRATGAACGREFTVVVGDREKGEFVVLGSADDRWGVLVGSSIPAPVGCRSIEASWHGVYVHRQDGELPPREMGRVMDLAVGSEHVLATVDERTVVACGWGEHGNCGPVTDAQGNVKGICSPISLPEEALDVVGIGAGCATSWVITRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHD1</accession>
    <name>A0A317WHD1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_97324</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Protein phosphatase that specifically binds to and dephosphorylates the molecular chaperone Hsp90. Dephosphorylation positively regulates the Hsp90 chaperone machinery.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466790.1">
        <property type="nucleotide sequence ID" value="XM_025617767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHD1"/>
    <dbReference type="STRING" id="1450535.A0A317WHD1"/>
    <dbReference type="GeneID" id="37119910"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000039">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY85773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="329" mass="37372" checksum="4C16A91C9102E4A2" modified="2018-10-10" version="1">MAVDATYDGAPLGKAMTQEFIDDMIERFKNGKKIHRKYAFQIIKAVKDLVYAEPTMVEIGVEEGKRLTVCGDTHGQFFDLLEIFRLNGYPSDTHAYLFNGDFVDRGSWSTEIALLLYAYKWLRPNGIFLNRGNHETDDMNKVYGFEGECKAKYNETVFKVFSESFSALPLATLIGNKFLVLHGGLFSDDKTTLDDIRKLNRHNQRQPGQQGLMMEMLWTDPQTEPGRGPSKRGVGLQFGPDVTKRFCEKNGLEAIIRSHEVRMNGYEVEHDGRCITVFSAPKYCDTTENKGAFIKIGPELKLEYQVFEAVPHPDIKPMAYAQSSLMSMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WIT6</accession>
    <name>A0A317WIT6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-methylcitrate dehydratase PrpD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_556870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466975.1">
        <property type="nucleotide sequence ID" value="XM_025613895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WIT6"/>
    <dbReference type="STRING" id="1450535.A0A317WIT6"/>
    <dbReference type="GeneID" id="37116038"/>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="46"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="323"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY86384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="521" mass="55917" checksum="D154B8EC1DBEBF82" modified="2018-10-10" version="1">MVVVAVQSQTAASAAPSTISNGIDKETHTKTQETTPYNADGGVTSQLCGWIAGLQLDDIPEAVRTRAKYLVLDGLACALVGARVPWSQKAFDAMRAFEAPGKHVVIGYEERLGAVAAATLNGSWIQACEVDDYHSVAPLHSQAVVIPPLFAAAVSSKDHPTTPRVIDGQSFLLASVVGFEIGPRVGMALHGTEMLAKGWHCGSVFGGPAAAGSSAKLLGLSAAQIEDAIGVAATQACGLMAAQYDGMVKRMHHGFAARNGLIGTMLAWGGYEGIKKVFERPYGGFLAMFGLGSKHTPNSKPEEISKDLGQFWHISEWIRLKLHACCGGIHGTIECLAEMQEQYPDRLRGAAQLATIKDIHIQLSDAVYHHCGWAPEARPLTPTGAQMNTAFVAASQLVDGQVLLEQFSSGKLDRDEIWDLIHKTHCTHTTELDKPNIGCGSVITITFEDGTQLNHTLLKPKGVDEPITNEEILEKFRRLTGSLIGPERQAQIEQAVLNMEALEDVDELIELLSVPVVNPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJL6</accession>
    <name>A0A317WJL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_493368</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467144.1">
        <property type="nucleotide sequence ID" value="XM_025609199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJL6"/>
    <dbReference type="STRING" id="1450535.A0A317WJL6"/>
    <dbReference type="GeneID" id="37111342"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY86553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="431" mass="49417" checksum="E87A1426A1D61FA8" modified="2018-10-10" version="1">MAEENKPVAQEQDINPWSVDGGRDENGEVVAINYEAICRKWNTSVIDDKLLERFEKVTGHKPHRWLRRGLFFSHRDFDRILTLYERGEPFFLYTGRGPSTGSLHLGHTIPLQFTKWLQDVFDVPLVFMLTDDEKALFKDTVSFEDALHFAMENAKDIIALGFDLKKTFIYSDLKYVSNHFLMNAWEFSKLVTFNQVRGAFGFNESTNIGRIFFPSLQCVAAFGTSYPEIWKDEPLQTRTQEIANIQCLIPMGIDQDPYFRLLRDNAHRMTYPSPKPALIHSKFLTALQGAGGKMSSSDPNSAIFMTDTAKQIKTKINKYAFSGGQVSIEDHRRLGGNPDVDVSYIYLTYFEEDDARLEEIYKSYKSGELLTGELKKMTIEILQQYVAQFQEKRKEVTDEVLAAYMKPRKLEWKGNPNPVPAPAPAIRTKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKN1</accession>
    <name>A0A317WKN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Amine oxidase</fullName>
            <ecNumber evidence="15">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_518392</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="15">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="14 15">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="15"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466869.1">
        <property type="nucleotide sequence ID" value="XM_025610032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKN1"/>
    <dbReference type="STRING" id="1450535.A0A317WKN1"/>
    <dbReference type="GeneID" id="37112175"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000019">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 15" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="17">
        <location>
            <begin position="21"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="18">
        <location>
            <begin position="111"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="16">
        <location>
            <begin position="238"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="13">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="14">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY85852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="684" mass="76573" checksum="0A14F31B89070B99" modified="2018-10-10" version="1">MVLERLQQLTHQVKATSPPPHPLDPLSTAEIDTAVAIIRKEYGKVNFNAVTLYEPRKAEMMAWLEDPQKVPRPTRAADIVAIAPGGKVYDGVVDLDDKKIVRWEHTPGVQPLITMEDLQEVESIVRKDPKIIEQCAIIGIPKEDMDKVYCDPWTIGYDERFGTDVRLQQALMYYRPHVDDSQYTYPLDFCPIFNAETKQVIHIDIPPVRRPISKAAPNNYHPASIEKEGGYRTDIKPIHITQPEGVSFVVNGRSIDWQKWNIHVGFNYREGIVLNNITFNDNGNVRPIFYRLSLAEMVVPYGNPEHPHQRKHAFDLGEYGGGYMTNSLSLGCDCKGAIHYMDAAFVNRAGASTIVKNAICIHEEDAGILFKHTDFRDESVVVTRARKLIISHIFTAANYEYCVYWIFHQDGTIQLDIKLTGILNTYAMNPGEDTKGWGTEVYPGVNAHNHQHLFCLRVDANVDGPNNTIFQVDATRGAGEVGSAENKYGNAFYAKKTKFTTPLEAMSDYDGNTGRTWEIANTNKLHPYSKKPVCYKLVSREIPPLLPKEGSLVWKRAGFARHAVHVTKYSDDQIHPAGRHVPQTSGEPSQGLPAWIQEAGAYSSIDNTDVVLWHTFGLTHFPAPEDYPIMPAEPMTLLLRPRHFFARNPALDVPPSFARTPSQVAAGAASCSSCKKSDGSSVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL09</accession>
    <name>A0A317WL09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467281.1">
        <property type="nucleotide sequence ID" value="XM_025611724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL09"/>
    <dbReference type="STRING" id="1450535.A0A317WL09"/>
    <dbReference type="GeneID" id="37113867"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="327" mass="36290" checksum="5F923E18E5DC26AC" modified="2018-10-10" version="1">MAYMNKVFADYAARQAILQTSTNPYAKGIAWVEGQVVPLSEARIPLLDQGFLHSDLTYDVPSVWDGRFFRLDDHLTRLELSCAKLRLKFPIPRDEIKQILIDMVSKSGIRDAFVELIVTRGVKSVRGIKAEDLVNSLYMFIQPYVWAMEPEAQLIGGSAVIARTVRRVPPGAIDPTVKNLQWGDLTRGMLEASDRGAMHSFLTDGDAHLTEGPGFNIVLIKNGVIYTPDRGVLHGVTRMSVIDVARACGIEARLEVVPVELAYRCDEIFTCTTAGGIMPITTLDGKPVNGGQIGPITKKIWDGYWAMHYDPAYSFEVTYDDEVKAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL19</accession>
    <name>A0A317WL19_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_546423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467404.1">
        <property type="nucleotide sequence ID" value="XM_025613297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL19"/>
    <dbReference type="GeneID" id="37115440"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="276" mass="30532" checksum="818F2E0516FF6CEA" modified="2018-10-10" version="1">MNPLNATLHTSQSLDLTLAEPRHVSTSAVCSYLSYAPVNQAVKSSVSPTHQMTQATSRDRTQDSTRQQEYRHDTHVILVHPATRHADGFHIRVRSHAQEETGGEPGGEDKVTALVSKLPGAWMRNAGDGFKQGSGWWLNIHTCGEMAIDIEALIQTHGSRSTNARDAWHPSLVSQSDHNHNKGGRGKEASPTKQCHQGYRKTWLVLAQIELPRPQRSLVPEFAGIGRLPYSVVQHRRQKHDSQTTAVRSISGRSDPGKGKSEEDPEQSQCHAWVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL54</accession>
    <name>A0A317WL54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_95990</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466765.1">
        <property type="nucleotide sequence ID" value="XM_025617760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL54"/>
    <dbReference type="STRING" id="1450535.A0A317WL54"/>
    <dbReference type="GeneID" id="37119903"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09534">
        <property type="entry name" value="SAM_Ste11_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000075">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000214">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029458">
        <property type="entry name" value="Ras-bd_By2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14847">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01304">
        <property type="entry name" value="Ras_bdg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="12">
        <location>
            <begin position="63"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="625"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="147"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="211"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="535"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="558"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="654"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY85748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="904" mass="99955" checksum="DAC81806063CFADD" modified="2018-10-10" version="1">MLAKATYNPLGVSATQTPTASYYTGSSQKTTAVGDTQKGMMFVSPTESSFSDVYDGLDAVRSWDEKQVIAWLHSINCGQYEALFKANNFNGNNLIECDQKILQEMGIKKIGDRVRIFVAIKQLRNKSVLNRKSRNLNSLATLESVSYTNASSEPSRPPTHRQTSNTRRSSRAAETNSLSYSANRPSSRPESPLRPQQYVANSPMEMGRMEQGQSYFSHPSSSSSMTSRKPGTPSERSGSHLRQNPSLDGMTMGQLPTNSPVIRVIYTGGQTKMLDIKHCKTADEIILCVLKKLQLPEHQYRNYCFYVLDGLEPDAAHCRRLTDPELLDVCESPHRSERGRLILRKIHAGEPDPDELRRASQLAVEGSQLAHMNALSSSNVRNQLKIQQLTGEPWHNIRQPMSPVSSRHNQTPSEHDIRPPMNVERQVGKLRSFFGARPPSEMIIHEITSYFPSHQREEIEKTMRMSVRRSQRLSRAASRLSVVSNTSYASSLRDAPPIPSIADTWLNTGGPPSRASRPLSVSKFSLPTATYRDSIASSSLQPLQEESPIEPNRKSYVSFDSGSDDPTTSRQSVVDANVDENASVAATDGGSFNERLSILVAEDGEEEDDGLNDFLAGNNFAPKNWMKGSLIGEGSFGSVFLALHAITGELMAVKQVEIPSATKGTEFDKRKNSMVTALKHEIELLQGFHHPNIVQYLGTAADDQYLNIFLEYVPGGSIATMLKQYNTFQEPLIKNFVRQILAGLSYLHSRDIIHRDIKGANILVDNKGGIKISDFGISKRVEASTLLGARASGGGGHAHRVSMQGSVYWMAPEVVQQTIHTKKADIWSLGCLVVEMFTGAHPFPACSQLQAIYAIGKEKARPPAPEHASKEAVAFLDMTFQVDYEKRPAADELLKCQFLANPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL73</accession>
    <name>A0A317WL73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UPF0187 domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_535909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466785.1">
        <property type="nucleotide sequence ID" value="XM_025611894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL73"/>
    <dbReference type="STRING" id="1450535.A0A317WL73"/>
    <dbReference type="GeneID" id="37114037"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY85768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="474" mass="52885" checksum="6DE2C5DBA29F4660" modified="2018-10-10" version="1">MAEEASHDSLAPVAVELPAVGPQLEKEPRPGRLTPRPSFLENLASSRATQFMLDRRNSSELDRYFHGPRDLDRHSKWPIFLRMHGSIMPKMILPLAFVAAWATLITCIAKFVHNIGINDILLTVTGFVVSLALSFRSSTAYERWADGRKYWALLNQTSRNLARTIWINTAERNGEEGKEDLLSKLTAMNLILAFAVSLKHKLRFEPDVGYEDLAGLVGHLDTFAKEAHDREVLQPPKKTPWKSFGEYLGVSFAESNPRKLVKRSKKPLGHLPLEILNHLSAYIDRCIANGTLSVSLHQSQAITAISTLNEVLTGTERVLDTPLPAAYSISIAQIAWIYVLALPFQLYEFLNWVTIPASMVAAYIILGLAFIGSEIENPFGHDVNDLPLDTYCRQLAVELDIITAMPPPRLDDFGTRDDNYVLYPLSTCGYPEWKDRSVEEIRAALRTKVVANYPGATMSDAATVIGSVRSKQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMA3</accession>
    <name>A0A317WMA3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_535285</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467393.1">
        <property type="nucleotide sequence ID" value="XM_025611749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMA3"/>
    <dbReference type="STRING" id="1450535.A0A317WMA3"/>
    <dbReference type="GeneID" id="37113892"/>
    <dbReference type="OrthoDB" id="440202at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.610:FF:000002">
        <property type="entry name" value="Hsp90 co-chaperone Cdc37, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="204"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="382"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY87185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="491" mass="54689" checksum="60A1EE94B7CCAF8C" modified="2018-10-10" version="1">MVLDYSKWDALELSDDSDIEVHPNVDKRSFIRAKQAQIHQQRSQRRYEIDTLKYEHIVNDGLLSRIDQLLTSLKQNEGSKSVEEVIFQNLMEFAGNPSEDHPPPPPAGVHTQEKEQPKYSQMMSALLDQVKKEMGDVSTENLYKEYIKGVQGHENKVQGLQRELLQRLDQLEKEERSKITSDKLHEGFNTSHIAKGGEAGSTGSSQQTGTVELLNPGASTAGSSQLAAAADDDEEEDPENIKASDLAKRFAKIDRSDYRALLQFVSANPQIVAEKETDGLLVEAFNSQMEGKDDYARTCVHQGLLLQYCRSLGRDGISLFFKRITTADHQAGTLFRNDVNETYNKIKTRAAELAKDSSASNDPAGVEQIQLHAVDPNTKITINIPAAESNEPIEVEARKIFESFTKDLQTALASESLDEVNKVLGKMSVEEAEDVVEKLGQSGMLSLEEGIVDATTEEGRKRLEEIEAENKREREEQQEIGEPGGDVTELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPY4</accession>
    <name>A0A317WPY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_64519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467888.1">
        <property type="nucleotide sequence ID" value="XM_025617570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPY4"/>
    <dbReference type="STRING" id="1450535.A0A317WPY4"/>
    <dbReference type="GeneID" id="37119713"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO/CreE_NAD-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-dependent urate hydroxylase HpyO/Asp monooxygenase CreE-like FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="13"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="308"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="431" mass="47754" checksum="0440AD9E4A2A1A45" modified="2018-10-10" version="1">MASTTNENPLRIAIIGGGIAGVTLLLALLKHSSREIIAPHLYEATPEFSEIGAGIAFGSNSIRAMELIDRDMAAAYNKHATFQPDTGALEKKLWSSYRMGMDGRGSNTLKAGDYIHEVHASVARSSVHRARFLEAMTALLPTGYVSFGKRLTSIDDVEDGVTVHFADGTSVTADAVIGCDGIKSRVRQILLDGEEEANAVFTGKYAYRGLIPMDEAVGALGEYTARNNHFHWGYDGHLLTFPIEHGKTMNVVAFRTKPNGVWEHGSQWVLPGNKEQMLQDFEAWGPDVKAILSLMRNADIWAMFDHPPAKSYHRGGRICIMGDAAHASTPHQGAGAGMAVEDVYILSRLLGKVREKGQLERAFAAYDAVRRPRTQRLVRTSRDAGRLYQCQKEEVEDDVEKIRANLDERMRWIWDLDMEQHLEEALSVFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WS15</accession>
    <name>A0A317WS15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_623890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468187.1">
        <property type="nucleotide sequence ID" value="XM_025617181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WS15"/>
    <dbReference type="STRING" id="1450535.A0A317WS15"/>
    <dbReference type="GeneID" id="37119324"/>
    <dbReference type="OrthoDB" id="4446873at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="332" mass="37144" checksum="22974D1D4099A2A0" modified="2018-10-10" version="1">MAPTTRSTSSAAPAAGGSINTSDFLNTAINTDPRTQAEGLPSKLPGSLQGVTELLTGRKNFERWHLWVETSLRPLSLYQLLQKDLPRPQIDDPSYNLWHRLSSIICAWLLKQLSPEISERFVRAEGGREFADNAYKTICKIALGEELIKVINTCIKLVSESRNNYSTIAQYINSFMNTFTTAQRIRCKMPAFMATCILLSNLETELPTWTTPIRIALPLANPDTLTNTDFYKYCDEAIATGNGLDAKHLAASAPIIQASAAPRDIKSDHWKKRTFPEPGISPEDHVAKMRNQQPQQLDRKCAYCHIGGHGSLVYYHLNPSLRPPHWKPTRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSK1</accession>
    <name>A0A317WSK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_534204</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468345.1">
        <property type="nucleotide sequence ID" value="XM_025611487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSK1"/>
    <dbReference type="STRING" id="1450535.A0A317WSK1"/>
    <dbReference type="GeneID" id="37113630"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF13">
        <property type="entry name" value="ENDOPOLYGALACTURONASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016259049" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="21"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY89434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="364" mass="38000" checksum="793D2207A98BE38E" modified="2018-10-10" version="1">MHFLQNTIVAATMGAALVAAAPLELEKRSCTFTSASAAKSGKSSCSTITLDNIAVPAGETLDLTGLKKGTTVIFEGETTFGYKEWKGPLISMSGTDITVKQASGAKINCDGSRWWDSKGSNGGKTKPKFFKAHKLDESSITGLKIYNTPVQGFSIQSDHLTITDVTIDNSAGTSKGHNTDAFDIGSSTYITIDGATVYNQDDCLAINSGEHITFTNGYCSGGHGLSIGSIGGRSDNTVNTVTISNSQVVNSQNGVRIKTVYDASGTVENVKFEDITLSGISKYGIVVEQDYENGSPTGTPTNGVKVDGITFEKVTGTVKSSATDIYILCGSGSCSDWTWSGVNVTGGKKSSKCKNVPSGASCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WST8</accession>
    <name>A0A317WST8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication regulator SLD2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_556432</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Has a role in the initiation of DNA replication. Required at S-phase checkpoint.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SLD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467761.1">
        <property type="nucleotide sequence ID" value="XM_025613865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WST8"/>
    <dbReference type="STRING" id="1450535.A0A317WST8"/>
    <dbReference type="GeneID" id="37116008"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22289">
        <property type="entry name" value="RecQL4_SLD2_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1460:FF:000001">
        <property type="entry name" value="DNA replication regulator Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021110">
        <property type="entry name" value="DNA_rep_checkpnt_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040203">
        <property type="entry name" value="Sld2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28124:SF1">
        <property type="entry name" value="DNA REPLICATION REGULATOR SLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11719">
        <property type="entry name" value="Drc1-Sld2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="245"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="425"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY87978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="501" mass="55810" checksum="C01940D64CD6631E" modified="2018-10-10" version="1">MATVIVPEVESQSANLRAELKEWERAFADANGGKKAERNDIKKVPEIAAKYKEYSRLKALESKNEKKAIRLEERLKKRKHSSPTGPENVDTTSTPRKAAKGIFETPSKSRVATSHPSEVDPYDSPSVLRRLFSPSTHQSPLKAAIGPTPQRDGKALGLFDLLSESGGSTATPSATRMASVRDTAAQTPSRRNQLDTIAEEEEENPRPERTPASSGKKWMLSTLFATPTTWRYAMMENKGHRYPAYFKNEPEPETANEGPNESETPSFLRRSTSGRYDATNAGGLSPIAVRKRPQFVGKGLSVLVQGLRDMEEEQMQDDMDVLNEIEAEQAALNDVGDSQAPDEPGRTFKKKGQKRTTRKVRMKPVVSKPRPEPQLPGSDDEGEHLEEQDVVPETQHLNAPEAEADEVESLHSISEPDFDSDPDYDESKPTRSKSFSERMKEAIAADKPQEEPQKAPQPKAKEQEKKPPARKVNPAAHANYRSLKLRNKNTKGRGGRRFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT07</accession>
    <name>A0A317WT07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_516508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467841.1">
        <property type="nucleotide sequence ID" value="XM_025609965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT07"/>
    <dbReference type="STRING" id="1450535.A0A317WT07"/>
    <dbReference type="GeneID" id="37112108"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000025">
        <property type="entry name" value="C6 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="685" mass="76412" checksum="F35C4C254BE8F1F0" modified="2018-10-10" version="1">MDVSQSRRILRKTFACDECKRRKIRCSGNDNCSNCRRDAKPCRYSSPSQRLSTLQRRLHESERLRADMERAWSVYLPSVDLQDALQTVRLQNDSIPTTQQQGQHRQKHLSDVTHAIEQPPANFVEPNNAEDYEFDESRDFDNSTDGMGFLTVDPHKAGYTGPQSGVAALKFLQSLPLYLPLTSFSPSSSLDDDDEGASASAIQQRRQDVLRYLDDYFAFYHPAYPILHEGTFRARVSGALAKPRDGSWPILYNIVLAIGAFVGDSQGTKVDIPFYKEARKHLSMDVLEKGSLSYVQGIVLMANYMQKRNKPNAAFILIGIGWSMALAIGLHREFGMPSTSPFTMEIRRRVWWTLFVFVSGVQLTLGRPAVSLVGVNVRLPANVDDHDLAVDMDELPECGTGPMITSCLIAQVNLAKIANVVQVELLTHHLPTHQKAADLEQRIHTWYHDLPPHFGFNVPLESRFDIPRRVLLWRSFHLRIVINRPFLFQSIAAKSDLDTSAGPVATCLTAADECVASICSFLESTDNRRRGLTWYATCWLLTASFVQATCYIYEPGHSLAPAWKCHIQRAVDCLGSLGSSHDMALRARDVLQNILEHGHGIADGADIAPYVSSQHPGSFRPLWFPGDQPTFKSVSLGLDNSLASYAPGSFNAEFLDAAGGLMIQNLFDNYYEERSQNAAGSSIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTC9</accession>
    <name>A0A317WTC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Guanine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_623637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468574.1">
        <property type="nucleotide sequence ID" value="XM_025617164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTC9"/>
    <dbReference type="STRING" id="1450535.A0A317WTC9"/>
    <dbReference type="GeneID" id="37119307"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01298">
        <property type="entry name" value="ATZ_TRZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="62"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="480" mass="51465" checksum="F6396696FE9E16F8" modified="2018-10-10" version="1">MSSAMPKTTLFVHATIITINNDREIIRDGYLLVQDTRIAAIGRCPAPADVSPDVTINCTGKIILPGLINIHAHLVQSLLRGLAEDLPLHNWLCDAVWPLESSYEGRDGYHAARLTIAEMLKTGTTCFLDPMVTYRAGWENVCDAVGEMGIRGCLGKLVKFPETNRQLSITDPRDKDLLAMSIPALAAAHEKHHGTHNNRLHVWAAAGTPRGAPASLYRELGEVCAAHGISVTMYCAEAPKDREIYHDLYGCSAMEFVQDTQLCSQISTSAGRNESHNLVLAHMVNLDLDTDLPLLGATHTSVAHNPTSNLKLASGVAPVPAMLGAELEINVGLGTDGAPCSNHYDMFQEMHLAAILHKGVCRDATVVGAETALEMATINGARALRLENDVGSLEVGKKADMVVMDPYGKGGLGAAPWHYEDGGGVTAITTVVHGCTGRDVDITMVDGKILVVDGRLVGGQEPEIVNLAQLASREIRARCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WV64</accession>
    <name>A0A317WV64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_534629</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468090.1">
        <property type="nucleotide sequence ID" value="XM_025611593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WV64"/>
    <dbReference type="STRING" id="1450535.A0A317WV64"/>
    <dbReference type="GeneID" id="37113736"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="135" mass="15712" checksum="1F087ACF2DAD942E" modified="2018-10-10" version="1">MQNLLSKEDEALTGSEDNEVRREDQEKINRFSRLHQRETMLEEQLKLKLKDKEDLEEISTELELADEDELVPYKIGDAFFQLPLEEAQSLLSTATEQVDVEVGKLEEKLSDLRDELQQLKVALYARFGRSINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVJ7</accession>
    <name>A0A317WVJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acetylornithine deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_462894</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468751.1">
        <property type="nucleotide sequence ID" value="XM_025607992.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WVJ7"/>
    <dbReference type="GeneID" id="37110135"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08013">
        <property type="entry name" value="M20_ArgE_DapE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006058">
        <property type="entry name" value="PRK08206.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42937:SF1">
        <property type="entry name" value="DIAMINOPROPIONATE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="952"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1148"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="954"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="841"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1094"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1132"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY90373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1326" mass="144154" checksum="EBD11177D27D0405" modified="2018-10-10" version="1">MPGSRRPIFVNPNPTTTSLGGLPRVQAFHEHFPGYAASPLVPLPDIADELGVRAVYVKQESNRFGLPSFKVLGASWAIYQAVLAALGLPDGTPLETLIARVQASAASAAITLIAATEGNHGRAVARVAQQMSLQCRIYVPCTMHEYTKQMIQSEGAEVVVVEGDYDRAVQAAADSAAEMEQRILIQDTAFEGYEDIPAWVVEGYSTLLREADEQLHALGLLNTLVVAPVGVGSFGQAVATYYKSRETPAAVVAVEPDTAPSLTHSLQQGKLTSVITSPSIMAGMNCGTVSSVAWPLLQQLVDASVTVSDWESHGAVQDLTAQSVDAGPCGAASLAAIRRLKAEHHGSAFFTPESVILLLSTEGRRPYEVPQDVSTDDPVKLTQMLTRINSSNPTLSKSRGAGETAIVNYLSAWFSHRAIEHHRIETTPGRPSVVGIVRGSGRGSSIMLNGHVDTVSLTTYEGDALTGHRGVKEGKEVVFGRGVLDMKAGLAAGLSALLVAKESPLAGDVMIAAVADEEDASQGTIDVLAAGWRADAGVVLEPTNLAIAHAHKGFAWAEVEILGRAAHGSQPADGIDAIMNMGLFLQALRETQAQLPVDAVLGQGSLHCGIVHGGEEASSYPASCKLTVEYRTVPVQTNQGILDDLGALLDRLARENAGFQYREPRITMSRPSQHVPHDHPLVEQLVHISQDVIGHPAAVQSVPFWCDAALLTEAGIPSIVFGPCGAGLHSREEWVEVDSLPAFRFYSSSSSFSSPSSSFPAPIFLLAPFPSSVFFHNGFSYICVSRILNYQAGNLGFAMEASFPDSSRASFDDDWAEWLSTSDSIHPDTFSYPAGPVENTSLDPVIPGETRRDFAETDPTNHSSIRPTDDFSVSRWLEGAYRPSVPCAHCQQHRLQCLIIRTTPANPNPVSSCSSCVALFRECSLARGEKRHPAGFETFFPVFNHLHGVTDENDGRHKPRFSRKGAKVLRDWLYRNQHAPYPTEEQKAQFAQQTGLTEKQISTWFANARRRHRVARRTSRPSQIFRSGSPMPVSRPPTLTPMERWQRSPPDQEPVSESAIQDAIAAAGTDTAWDCPSASADASPGAHNLASSISSMDSEPSHASSESVSSAWSHRSESYLPFPLSDVPSRSQSRRRRPRRRSAAEGPFQCTFCVDSFKKKHDWARHEKSVHLSLESWICTIGPDILDIAGSEALPCDFCNATQGFQSHFATHEFDVCVDRPLSERSFCRKDHLIQHLRKFHHCTKVPALRVEACRVVTNDVESRCGFCQLVMSTWSERADHLAEHFKSGARMMEWCGDWGLDTLHQAMLRDAMLPADRFSLSEGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVR0</accession>
    <name>A0A317WVR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_565208</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468293.1">
        <property type="nucleotide sequence ID" value="XM_025614481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVR0"/>
    <dbReference type="STRING" id="1450535.A0A317WVR0"/>
    <dbReference type="GeneID" id="37116624"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.20:FF:000002">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="607"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="673"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="765"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY89382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="860" mass="94616" checksum="E7EDDACD9352C3B7" modified="2018-10-10" version="1">MSMRQPGPQTDAQSSLTQPYSDDEPQHPGVPLSGELREPLSFKRKQKQRSRFRFPNLFSSSAAESATNTGFGSLFRIEQPSDDMQPLREPVSGDGSMAHKDSGFLDWYVEGPGRRVGYDDLTAIDWIFEYTKERQRKRLLYASGQGIVGYLRKLLDSSNVWIVLIATGVLVGIIAACIDITSDWLGDLKTGYCRNGPGGGRFYLNRSFCCWGHDDVSECLDWTPWRKALGVSSSGGGYTVEYIFYVLYSVIFAVCACVLVRSYAIYARHSGIPEIKTVLGGFVIRHFMGPWTLAIKSLGLCLSVASGLWLGKEGPLVHVACCCASVIMKPFHSLNHNEARKREVLSAAAAAGVSVAFGAPIGGVLFSLEQLSYYFPDKTMWQSFVCAMVASVTLHALNPFRTGNIVLYQVKYTREWHRFEMIPFIILGIVGGLYGAFLIRLNMKIAKWRRSRNSSRPIIEVAVVALLSALINFPNLFMRAQNSELVHSLFAECGTGTTDDPFGFCKTGAVSAGTVALLLLAALLGFFLASLTFGLDIPAGIILPSVAIGALYGRGLGMTFRMWQEAYPKFFLFGKCEPDIPCVTPGIYAIIGAASALGGATRMTVSIVVIMFELTGALTYVIPIMIAVMLSKWCGDIFGKRGIYESWIQLNEYPFLDHRDDTTPPDVPAHSVMTTVDDITVITAVGHTIDSLRSLLLATSYRGFPVVTDTSNPILLGYISRNELAYALKYSTTPSDSELSGATQVFFTHQPFADPAETLDLRPWMDQTPITLNSNTTFLIILRMFQRLGLRYVLFADKGVLQGLLTKKDVWSVVSGPASHQDDTLHERTFNPGNTAERVGLLESDDGTSLASTIERRQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW01</accession>
    <name>A0A317WW01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ribonuclease P complex subunit Pop1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_565118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468901.1">
        <property type="nucleotide sequence ID" value="XM_025614474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW01"/>
    <dbReference type="STRING" id="1450535.A0A317WW01"/>
    <dbReference type="GeneID" id="37116617"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="5">
        <location>
            <begin position="55"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="6">
        <location>
            <begin position="553"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="7">
        <location>
            <begin position="717"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="663"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="756"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY90523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="873" mass="96915" checksum="F9603D83E934A40F" modified="2018-10-10" version="1">MAFNPASKRKPAFAGNQNGSAAARKRAKTFDARSLAVQAADAALSASGELDVAAYVEAREFEIRSLESGMQRSKSALTSRAFQKVPRSLRRRTASHNVKRVPKRLRARAKREMLEDNTPTVSSRTRKPTEQMRIRLETARRLQNLNKKSKAKREALKAKRDKNTRKTLEESGSHAFEIAPRVPKIKKNTLSRPIPPDAKFKKRQRCKTWLPTHMFHAKRAHMTTSKDPLWRFALPVSPTEKSYRPTHRARGIRGAVAWDMSYMATVQLEGTEEALEGVLRAVGVDGEDAWGVKGRKWRAGTRCLRAWMYELEGDQLPIAPVTLIRCAEAKVEDVDMVDADDAGKEKRKKDRKKIFVRVHPSAFLQLWNALLGASKKQNPPVMVDDLRFEIGSIEITGPGAMEALLASFKPVAVDGKDIPANSPEATWSSLLGVSNPSSLPQNAVLGFSVSDPRLEFPPKTLKPPSSDTQMQDLAILLSSWSPDNTQEAPALFDRRTRLAAARQLPSQKAINRRRTEAGMGIRPPAKDTDPKIPVIALACRPSVYTKNSNAPGSWTVLLPWKCVLPFWYSLMYYPLSSGGNPRFGGLKEQQQLAFESGEPWFPGDFPGIRAGWEWGLRERQEAKQEWERRPKGRRVEYESIDLRNGQKGEVGRGWACDWERLVQGPTESSTKDNEEPSEAETKPEDSAIHPPIDIHQVSTSLAASALKCPSFTADASALMTVKLSLLNRGTPTPRARIYRLPTTDPELRQKWLSLASNKPDDTEKQLQKQQARGSALSNEEARQRLAASLIAPSADADARQDHLPIPTEADLIGFITTGNYNLAEGKGTGIGSIQLSKVTKNTGSSKGITNGRNMCIIRSAGETVGRLGFWELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY13</accession>
    <name>A0A317WY13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_565429</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468589.1">
        <property type="nucleotide sequence ID" value="XM_025614495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY13"/>
    <dbReference type="STRING" id="1450535.A0A317WY13"/>
    <dbReference type="GeneID" id="37116638"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF16">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="8">
        <location>
            <begin position="329"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="6">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY89678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="526" mass="60300" checksum="2788B85960B18EAD" modified="2018-10-10" version="1">MYNNPILPGFNPDPSIIRVGGDFFLVTSSFEYFPGAPIYHSTDLIRWALIGHALTRPSQIQIQTPEPGGGVWATTLRYHNGVFYILAACFQRYRPQDDDRVWPRGFYVKTTDIWDSESWSDPVYFDQVGFDQDLFWDDDGTVYLSSTYRKLERTPNANLKDFAIHIVTVDLETGASTSEPKLIRESTSGVAEGSHIFKKGSYYYLFTAEGGTESGHCEWVSRSTTSPFGPWEVGSANPLWRNGKDDAVQNTGHADLVEDASGQWWAVLLGVRPVWRDECWEESVFGRETFLVPVDWENDWPVVNCGQKIPLQSDSPHLYELSVPVTWYDDFSARDLQLGWYRKNTPVVRDYSLTERPHHLRLYGGPYNLSDPACPTLFLRKQTHRFCTWETRLSFHLTNSAAEAGSVVWWNYFTYSSIGVRSKNGRRFVRLRPVQDDPVDCDLHHLQSDVRFIVECGDRYRFGIQEVPDEEPVEEPIRWIGEVDNRSMTAAPAVGAAFTGMMLGVYAFGERQRCLVPADFHYARWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYH9</accession>
    <name>A0A317WYH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_393929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469182.1">
        <property type="nucleotide sequence ID" value="XM_025607341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYH9"/>
    <dbReference type="GeneID" id="37109484"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="98" mass="11077" checksum="262D56EE9456C87A" modified="2018-10-10" version="1">MNPCGNVRGPTCMVNVLPVSYTVFTITIPAYCRRRADSINLIIITSKMNQVAIEHSIRQALINFDKKLTENHVDIQCSQSRCCRVNCTTWIYLVAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZA3</accession>
    <name>A0A317WZA3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_617019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469434.1">
        <property type="nucleotide sequence ID" value="XM_025616816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZA3"/>
    <dbReference type="STRING" id="1450535.A0A317WZA3"/>
    <dbReference type="GeneID" id="37118959"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="64"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY91706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="501" mass="55311" checksum="827881C8F345721C" modified="2018-10-10" version="1">MAGNNPLDADMYRSEIMKGNDNEQVHLEDIPPTPPDQQSSNMVLGLDASPANPQNWPAWKKDTQILMVAFHSMAATFMAAGIIPAYDAMAEAYAVTVPQASYLTSAQILLLGVCPIFWKPITSTYGRYHVSMFSVLGSMVCNIGGARCTTYGTQMVTRVLTAILISPPMGIGSSVITELCEPEKRAQKLGWWTLMLTLGTPGGPFIMGFVTKHVGFEWIYWIFAMINFAQFIAYLLLGEETLCVPADRDNHVASMARPRFFQKLVPRRINPRPLKPREFIEPLLFARLPKVLIPACAHAIVFCYGNIALIVEMPIAFGEKFDFDSQQIGLQFVAIIIGCLLGEQLSGPMSDWFLRVMHRKRGYHRPADRLWLSYIGFGTVIAGLLVWGFQLEKATSWNVTPCVGAAISSFGNQIITTILISFAVDSYKESSTNVGVCINFFRHIYGFIGPFYFPPMFDSLGLAGAAGVMCAIIGVCALPSIIAIQFVATRADQKTEDEVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X033</accession>
    <name>A0A317X033_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS monocarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_564941</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469363.1">
        <property type="nucleotide sequence ID" value="XM_025614463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X033"/>
    <dbReference type="GeneID" id="37116606"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="27"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="28"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY91635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="456" mass="48803" checksum="5B3E7C9F389C05DA" modified="2018-10-10" version="1">MPRLEPISVVASPPEGHLARDAKWKSVIIVAASFVIIFTCCGLNFAWGVYQALYESLSRKPGTPFTGATPAEIDLIGTISVSLMTIGAPFAVAWAKRFSPRMVSFAGGFVFGLSLVVASFGTQLWHFELAQGLLNGIGTCLCYMVPVTIAPTWFTHHRGLAMGIILAGTGVGGLVWAPALTACVNNLGYRNTLRMTGGLSFALISIASGAMAWEPGSRTRIEMENSTRTSRADGILKVPLVDWRVARTRRFMAQALSAIFQAAAYYTPVFFYASYAQTLGYSTTASSNFIALSNACNAVGKIVIGHLADRLGRLNALFLTTFLSAIATTAFWLPSTLSGATTQSQGLFITFTTLYGTFASAYVSLFPASLVELFGVQNFASVNGVLYMVRGMATMVGTPVGGVLVRNTANALSPRGYENMSLLVSGLLFAATAGVVWVRLEAMIGPDGHARWKWRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X100</accession>
    <name>A0A317X100_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">7,8-dihydro-8-oxoguanine triphosphatase NUDT15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_555724</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469006.1">
        <property type="nucleotide sequence ID" value="XM_025613821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X100"/>
    <dbReference type="STRING" id="1450535.A0A317X100"/>
    <dbReference type="GeneID" id="37115964"/>
    <dbReference type="OrthoDB" id="447842at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035539">
        <property type="term" value="F:8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04678">
        <property type="entry name" value="NUDIX_MTH2_Nudt15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000060">
        <property type="entry name" value="Nudix hydrolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099">
        <property type="entry name" value="8-OXO-DGTP DIPHOSPHATES NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16099:SF5">
        <property type="entry name" value="NUCLEOTIDE TRIPHOSPHATE DIPHOSPHATASE NUDT15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY90628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="170" mass="19354" checksum="C43AEA3FD61CA88B" modified="2018-10-10" version="1">MSQPTTPSTIRVAVAVYVFNKHGQTILGLRQGSLGAGTWGHPGGHLELNETFEACAAREVLEETGLQVTDIRFLTAINNIMLEEGKHYVTVFVGCRLVDEDAVPKVMEPEKCVKWEWVSWNEMKLTVERQAEAERLGRMERYEGRVLFKPILKLFEQRRGFNPLEAYGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1A1</accession>
    <name>A0A317X1A1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_544758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469100.1">
        <property type="nucleotide sequence ID" value="XM_025613197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1A1"/>
    <dbReference type="STRING" id="1450535.A0A317X1A1"/>
    <dbReference type="GeneID" id="37115340"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="8"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY91372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="346" mass="37667" checksum="2549B5A2640BC5C6" modified="2018-10-10" version="1">MVQAVAVTAPATMSVVGDRPRPVLRDDCILVKTVSVALNPTDWKTVLRRNPTVIVGCDYSGIVEAIGPDVKKAFRVGDRICGTIHGCNPEHPDDGAFAEYALALGDLQMAIPERLNFQEAATLGVGLLTIGQSLYQSLQLAPLDHPLTQPEPILIYGGASATGTLAIQFANLSGYKVITTCSPEHEELVKSRGADKVFDYKKPGAAERIREYTEDRLTLVMDTISTEETAAFCVRAMSTQGGDYTAILDVKVPREDVRSRWTLAYTCMGKELTYREVTIPAKPQDRTFAEEWMETAVKVIADGRVVPHPVKFGLNGLQGVIEGLSALREGKVRGCKLVYNVDETSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X226</accession>
    <name>A0A317X226_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_513899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469335.1">
        <property type="nucleotide sequence ID" value="XM_025609861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X226"/>
    <dbReference type="GeneID" id="37112004"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="15"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="207" mass="22803" checksum="EAF82916AD040C4C" modified="2018-10-10" version="1">MSSINTALSFDDSYAVLNLDMMSILINAVKDTREGQTMITNCAKWNDAVHEKSPHPLTIFSTLAFSAGKPEVQSTSPFGRLIAPYGEFASGSADVRIHESFKVDKKDLVLEKTRWSATMGNSLEQILRARNIKTVIISGLSLSGVVMATIYRLFDLDFDVYVIGDNVLELPVDQTAAFSSVMLGMLLPKMGFKVISLDEALQMLERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2I7</accession>
    <name>A0A317X2I7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_380945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469560.1">
        <property type="nucleotide sequence ID" value="XM_025607263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2I7"/>
    <dbReference type="STRING" id="1450535.A0A317X2I7"/>
    <dbReference type="GeneID" id="37109406"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000271">
        <property type="entry name" value="Alkali-sensitive linkage protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016240720" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="46"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="281" mass="29914" checksum="30CABEBB106BA580" modified="2018-10-10" version="1">MVSFKSFLTAATLASAVLAIPHNGHSHKHRSTHVASKRSSSGSKRGAAYNTASSVHTLSSAASGNGTVSWAYDWNMYADGSLPSNVEYVPMLWGTKMFTGWLAAIEVALASGSNYILGFNEPDASSQAAMTASDAASSYKKYITPYSGKAKLVTPAVTSSTTEGEGLSWMKSFLSDCSECDMSVLAVHWYGNTADEFKTFVQEAMQVADDYGLEETWVTEFALTSDSTAGGDTTSGADFLDEVLPWLDSQSGVGRYAYFMCADGYMLSGEELSASGKSYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2J6</accession>
    <name>A0A317X2J6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_533298</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469570.1">
        <property type="nucleotide sequence ID" value="XM_025611303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2J6"/>
    <dbReference type="STRING" id="1450535.A0A317X2J6"/>
    <dbReference type="GeneID" id="37113446"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="40"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="236"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="499"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="20">
        <location>
            <begin position="603"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="709"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1091"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY91842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1235" mass="137982" checksum="F9EAADCCF804197F" modified="2018-10-10" version="1" fragment="single">MAPAATDTNWSVDYDVLRREKLFRNPPKDHTAYPALAAAIRPHVDSFNALFDGPKTLEAALKDIGTKTFIDGEAETPEQKKARQAEGRKAPRRNKLHVRVSEVFLEKPALPASNKFTTRNRNIYPSECRERHATYRGKLRARIEWRVNNGDWVESVRELGQVPIMLRTNRCHLEKATPSELVDHKEESEELGGYFIVNGNEKLIRMLVVGKRNFPMSIVRGSFVRRGHTYTKYGVQIRSVRPDQTSQTNVLHYLTDGNLTFRFSWRKAEYLVPVMMILKALVETNDREIFEGIVGSASSEGIKNTFVTDRVELLLRVYKAYNTHSRAACRAYLGEKFKPVLGVPADMSNEDAGTEFLRKVVLPHLGNQNVTENQDYDKFKMLLFMIRKLYALVAGDCAPDNPDAVSNQEILLGGFLYGMILKERLEEWVRSFQPILRDWSNRNGGAKFTDPAFERDFLSKVVKRSNENLGGALEYFLSTGNLVSPTGLDLQQPSGYTVMAEKINFYRFISHFRMIHRGSFFAQLKTTTVRKLLPESWGFFCPVHTPDGAPCGLLNHLAHKCLIATSDVDTTHVPKALIQLGVRSESSVSVAESVTVQLDGRIIGYCSPKQAAAVANTLRRWKVAGSDKIPRELEIGYIPNTNGGQYPGIYMFSQAARMYRPVKHLALDKLDYVGPFEQPFMEIACLPQDLISGVSTHIEYSPTNILSIVANMTPFSDQNQSPRNMYQCQMSKQTMGTPGTSIQYRTDNKLYRLQTGQTPIVRSPLYNAYGLDNFPNGTNAVVAILSYTGYDMDDAMIINKSSHERGFGYGTIYKTKIHALDDNESRRGKSRREITKLFGFAPGGEIRAEWRATLDEDGLPHLGARVKEGSLVAAWHTVRYDAASDSYVNVDGITHFVKYKDAEEGYIDSIRIMGAESGVEPCQTLSVKYRIPRKPIIGDKFSSRHGQKGVCSQLWPAVDMPFSESGIQPDLIINPHAFPSRMTIAQMIESMAGKAGALHGHPQDCTPFQFSEENTAADYFGHQLRKAGYNYFGNEPLYSGITGKEFAADIFIGVVHYQRLRHMVNDKFQVRTTGPVNSLTGQPVKGRAKGGGIRVGEMERDSLIAHGAAFILQDRLMNCSDSTRSWICRDCGSFLSTQVAVPSSGSSKARIAAAKAASNQHSGANALSGSPGIVRCRRCAREAIFEDSRADVWEDGDGHRYVGGDNVTIVAVPGVLRYLDVELAAMGIRMKFWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4F9</accession>
    <name>A0A317X4F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_582901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470275.1">
        <property type="nucleotide sequence ID" value="XM_025615511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4F9"/>
    <dbReference type="GeneID" id="37117654"/>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="282" mass="32212" checksum="F16C852D81BE0AE6" modified="2018-10-10" version="1">MPLHPASQAHRHADDFWTLDTLVPIAKFLHDKYLFDSLDLETHDWVLGAVQEPAELFIPAAEHIAKRWLQDYRWQPRICMLIIYRIRCLVNGDRDEVFTDSPTTSNVLDSAEWNRRVAMCLRDMSYFEEAQVHFEAALRLDCQIWLARGGLAYMYSLNGQHDKALDLYKANLEILDAAYLNTEIWDMLPHDVGSDDIADGYQSIGEEYLALNALAYFEKALDISRKGECLEKFIELRAADKVSESNEQNIQHSKRMGTASDDGLPRDIHAGELPSAILTILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4K7</accession>
    <name>A0A317X4K7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin C-terminal hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_532997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470036.1">
        <property type="nucleotide sequence ID" value="XM_025611250.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X4K7"/>
    <dbReference type="GeneID" id="37113393"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000136">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1602"/>
            <end position="1931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2519" mass="284337" checksum="8186B8A6B55F431C" modified="2018-10-10" version="1">MAAAPLDSSSTPPDAISTDSTRPLGHPMEESDPQSTRKRPRLDSGSRACESWSASNETAASRLSNHIPDAPATTAQEASPSSRPASRVAIKLKPPTSGDKMASAPEDSPAEHSSGDLPAPSAGEAGVDISTAISLSSSPAQSPEIEVADLEDMDQDPNTSSWKSLGEAMREPETPDVVQLQAPLTDTFPRIHMGNELRENLEEICAIIEKGSQHDIPVFIAVKCWLDDVANNLDQLTYEVLAEDRDFWEELPTVVDSLLRRTSEFLPDEGRGPWTCLQEFFLDYAQLALQIVGLDTFLLTQVMEDADAQMSDPLSKAYLPSLGWVLQLNNIPFFRAMEKMHGSEVSNLLARTNDQVASSPLDIVQRLSEHAVCILTLITRWPQLSTSLVSIVTIVHNLLESGNERRRYRADDALMNSSVYSRTMKRAYTLIRAADDKYQTHITKKSPWVSSDTSESMLRLIAHSYLTLCRRDPDFSSQIANDLAIQLLEGLTPDDRSYIIHYGWKFAVLKKHIMDGRMELRVHGMEAMQTDLVNVWRQHIQNNPDGVEHPVVQYLVGFLRQNRIVEYIVGIDSHPQLISRSGNIVGFLVVTSTYTDADTDTIWKTVTESPDPRTVSEVLGMLGKTFHMHLPTSPALLYLCSKLLDLPLSRFDARMIDFCEQLLHQVREKYSDRTRRDLQDQIHVDAIPLRLCVRLIRESAGADDLPVEHKALLQKFAGAQLSSFMEIGLSEVDKMETYEQCLQDIAEMNQFTVGSIQALNALLTNHDILELRKLAEEFDLTRLVITELAQMVGMDQTDFTDPFSLTGFSARIQMLARIIDMVPDSITPELGDLLWRKVFMCKTLAQQGRRALWDMLCGTTRYSAQANSFIERCIQVYLPELSPSEDYLPEVLLFAKQTINYEVRFNPPPMAGENEVVTIPGMDRIWSFILTAPPGTIETDATAFAIEVYLDQGVINRSPRSAVEATHIALVDRCVDQLKSAASRLKAYRGDISTTQDEPMQEVASNPDMVQAEELRFSRSLLFLRQFLQGLRSRPQYSPPQNLPPDLPGKPVQGEVIDIRYQTFNGGTQSKVRTLPIGDLSTAAELVETLVRVTGFTKFSTISGGQRTDLLEKPDMTIRDLKLGSGLLLIRRDSDSRELALAGRRQSLTLVDSEVLKHFDDLYDLLVLEDHLAREIYDFLVVFPPQDRVLQLVKSVDKTEDDMFPMDKPYSLLYSVNALSVTLREESLEASPNQECVSHSVSVLVSALTRPAMSDALGSSPAKLLFATHMVECLLYALLVRPALPGEASTVPNPAALAQQLFHFMEVARRLPGSYLPETGIAKLICNSFAVLTEGSVRDLSFWEAIKQQAQFDELLRSLLLEEHRQPIRKGIAENVAVTCSPSKLLRKPSKSVGSDTQETRGASASDNPIRIEILATIWDAFVKTFPVTLDHARQCQEFFEIANLVFRSVAERSPHDLAFSEYLKQWSATMLRHRTEEFVGREPVDHLILGFSRLLRLCLDLASSNDTTVDTSDLAESLFDQYLFPDLSLSSTAVVAPQIPVMHGQTRQELYSILCQLCRVDEDYSKIVERLEEIIPLEDYTYSPSWGFDRYKMIRSPEGYAGLKNLSNTCYLNSLLTQLFMNVGFRDFMLQLHLDDPEGTQRLLFETKKLFGYMQETWTKSVDSQAFVDTIRTYDNEPIDVTIQMDVDEFYNLLFDRWEALILDPECKKKFRSFYGGQLVQQIKSKECPHISERLEPFSAIQCEIKDKASLEESLQAYVEGEIMQGDNKYSCTSCGRHVDAVKRACLKDVPDNLIFHLKRFDFDMVTMLRSKINDEFQFPEFIDMSPFKVEYLSDQTAEVQEDVFELVGVLVHSGTAESGHYYSYIRERPTTDARGSWVEFNDSDVSRFEQGKLADQCFGGYNDSLQSSAMGQVRFNKVWNAYMLFYQRVSSMEAAKTIYNPTKPHHPVRVPLPVALANHIVMENEIFIRTYCLMDPYHALFIRYLLSMLHETKEPRSEKRSKLDKSMIFIALDTLEQLLSRARELLGLETFVTEILGVITDVPKAAYRVLQWFERKPAAIRNLILRSPHAAVRNSSMRIIMCALSKLQDLHQKADDGSTDKEKWQMRYLDGFENVVGTLDGLWSTLYTASRSWDDYFEFLLLLASFGQHEAGIVLNNGFLLKCLEIVWLEHEDSKRLRRQYAVFIKLMEKGRRFSYKKLMDLLALLLAHIDLTVPPSPDDKRRTLPDGRYTLTTIETALIRPQGKNKELSFLKIILTHNSSPAACRNIVSHFADAEPDAGLTNPICKALEEGLRVAPANLCAPFLEATLIFCRRGPDETKIADLIDFVSKGVETINNSGGREHLSFFTSIMGSRNDRLGLNEAWFLTRLIDTVPDWAPTLLIFPERAVRNMTLEVLRQILFSGETEEMGDDWQTHQTEVARKLVHASVDRLRKTYVNVPGCNVESRSVESIRTVIEHCLSTYFGDSEEDQEAVLQAHETIGAVEDLVVDVPEELASEDWEDNSVMASDSEMGLAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X550</accession>
    <name>A0A317X550_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_582837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470216.1">
        <property type="nucleotide sequence ID" value="XM_025615503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X550"/>
    <dbReference type="GeneID" id="37117646"/>
    <dbReference type="OrthoDB" id="10598624at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="223" mass="24051" checksum="A21E3A47CB324AC0" modified="2018-10-10" version="1">MGRQCDYARDTAHPDRRMRLAGPNQSVASTWLASRFMIDAPGPGPGGLGLPSAHCTLRVGERAARPLSASSNHDDNSYVTEFVSDKVGTRFLGSRWDLGQTKRIAEALSIPKRTMLSYSQHGISPQGPDVSAEPGRGAVQCAERADGMEPRVAKADLGTKKWLKQLLHQKIGWTLIESTETGSCSDTAMIGPSDWQCRSTAYDGGPKSKRQGAIAVTVSLPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X664</accession>
    <name>A0A317X664_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_532019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470820.1">
        <property type="nucleotide sequence ID" value="XM_025611029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X664"/>
    <dbReference type="STRING" id="1450535.A0A317X664"/>
    <dbReference type="GeneID" id="37113172"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2060:FF:000008">
        <property type="entry name" value="Sec1 family superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000005">
        <property type="entry name" value="Sec1 family superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="465"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="612"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="699" mass="79467" checksum="F400223B7EF7DCDE" modified="2018-10-10" version="1">MSSSILNIQHDLILNTIRYAAGNEWKVLVVDETSRKLIDNAVSEDDILNLNVTNVEQIEHRRSPNPTMDALYILSPLPHIVDCIMADFERKRYRKAWLVWTSFLDPQQRARLDRSEMAREQIANFQIMNADYFPRESRLVTFRDPWSFPVLFHPGCNHLIRTHLEGLAQKIVSLCASLGEYPVIRYYRPRTPTHEASVLCSHLARFVQNELDQFAQFQRDFPPPSPRPRGVLLVVDRSMDLVAPLLHEFTYQTMVHDLLPISDGDKVTYKTVINEGSPKEEIKDMEINEQDNVWVEYRHMHMKDVLGKLGEDFAKFRAANPQFAEDNDKANVNTIKDMLAGLTEFQQGRDAYTLHLNMAQECMKYFQDHKLLEVSAVEQCLATGLDENYKKAKNLASQIVQLLDDDAIKQPERLRLLLLYIIYRGGILAGDIRKLMAHAQLPPQDGEIVSNLDLLGARVEKPLKDDKPPVQPLFTRKPPSGPIDEEDGLSRYDLNLKLILEELVRGTLDAGVFPFTRPHADNDAPGQQDSASQASLRSAKPTWARTRTTGEQPRQRIIVFMAGGATYGEARTCYEMSQTYGKDVFLATSHMLSPGLFLRQVGDLSVDKRRLDIPAERPKPTAPAHLFEREPPPAPAPVKKPNPVPHLNPPAPVSALAAMSLGPNGKANGAPVKEKDEKEKKKEKKEKEKKEKKRHHFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7G3</accession>
    <name>A0A317X7G3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">H+/nucleoside cotransporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_484541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471240.1">
        <property type="nucleotide sequence ID" value="XM_025608961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7G3"/>
    <dbReference type="STRING" id="1450535.A0A317X7G3"/>
    <dbReference type="GeneID" id="37111104"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="197"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="281"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="384"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY94479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="610" mass="67010" checksum="4581B10B4264FA91" modified="2018-10-10" version="1">MVDEKTLATSQMTAITSKPCSEPTQPTDAHAAAPPMTVDESDAINTADTKKTTLEYPQNKENDIVEAGINYGSQKWYHRHATRYSKHIVYATIWILFTGWWITGLILHRFDLGWLIPFLLYLAITLRLIFLYVPISVVTRPVFFVWNQTASRLVSYVPERFRIPGAALVTIAVILVGAFASPETHENTRADRAVSLFGLVVCLFILWLSSRNRKKIVWHTVIVGMLVQFIIALFVLRTKAGYDIFNIISTLARELLGFARQGVDFLIEPEWAEKHSSWFLVGVIPAILFFVSLVQLLYYSSVLQWAIRKFATFFFWCMRVSGAEAVVAAASPFIGQGESAMLIKPFVPFLTMAEVHQIMCSGFATIAGSVLIAYIGMGVNPQALVSSCVMSIPSSLAASKLRWPEEEETLTAGRVVVPDDDEDKPANALHAFANGAWLGLKISGMIAATLLCIISLIGLINGLLTWWGHYLNINNPPLTIELIVGYICYPIAFLLGVSRNGDLLKVGKLIGIKIVMNEFVAYNALQNNPEYQDLSARSRLIATYALCGFANIGALGNQIGVLAQLAPSRSGDVSRVAVSAMLTGAISTLTSAAIAGMLITDEQQFARSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7L7</accession>
    <name>A0A317X7L7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">General amidase GmdB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_509076</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471290.1">
        <property type="nucleotide sequence ID" value="XM_025609687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7L7"/>
    <dbReference type="STRING" id="1450535.A0A317X7L7"/>
    <dbReference type="GeneID" id="37111830"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF3">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="88"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="240"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="550" mass="60766" checksum="494857A022E251FB" modified="2018-10-10" version="1">MTITQLITQDWRAIVAQRRKDLDSKIPQEWRLKENFVASLPRPNHLLASNAVEKSGILTETELDLTENYDATQLLQKLATGKLSSVAVTTAFCKRAAIAQQLTFCLTEHFFDFALERAKYLDDYLKREKKVVGPLHGLPISLKDSYHVKGYHTTIGYVSFLDHGLATSNSAVVDMLLDLGAVLYVKTNIPQTMLTADSDNNIYGRTLNPHNTTLTAGGSTGGEGALLALRGSLIGVGTDVAGSIRIPALCCGIYGFKPTTARIPYGGQVRFLYEGPPSVEPCAGPMTATFEDLELFMSTILNAEPWRYDVTTLGAPWTRPPTQSLLTIGVLAADEKYPLHPPVKRALQLAIEALTRKGHRIIYLDNDTNKDLDIAYANRLFWQYGTYAPRLDHVTPSGEPLVTSVAQGPSPMVTGSFPVSKDLGIFEKIHELHHKRQDYRDAWRKVWVDTGIDVILAPGAQNTAVPHDTYAWPPYTVVWNLLDYPACVIPYGQASKDLDPEPMAINDGMQPSYNPEAVDGAPCALQIITSRFQDEKCLAAARIIDRDIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7V6</accession>
    <name>A0A317X7V6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_563263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471457.1">
        <property type="nucleotide sequence ID" value="XM_025614349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7V6"/>
    <dbReference type="STRING" id="1450535.A0A317X7V6"/>
    <dbReference type="GeneID" id="37116492"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="787"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1000"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1101" mass="118256" checksum="94F0E625A59BD489" modified="2018-10-10" version="1">MAECDIPQLPRRSSSRTSSSSRRSQKARTVRARSQKRHSASSNATTTDLTSFPSLSPDRAPDGFIGQPALNRALTNALLEGESGDSMGDVSKDRRATLAKLTGTSTPSPGRAALFGDSVPIRDFPGALHLADDTHIERLVASTGAVKLVRQFARDLAQRDAEISALRQRADARERELKRMLREVSVSNQDIERRLYQLENAPLSDEPSQDTGGNAEQPGSSSSSVHGLMQQAMIDGIGSRSHEDGAETANHVQATVRGPQRLDSDARSGTSSVDSGTNRKRHSSIRSWQDFIFGNATGSRKTSRASSVMGEVEEQEETQRQRNLGNPSSRRKALDDQLFLPPEAQNGPGASEIAGKRLGASAGGDDASTHSRKSSKSLSSWTVKLFAGNAQSNKDETSGDDTRGRASSANRSTSKGVSPALPPNARGAVSAVAALTRINSNTSIHSASGRINGPSGIAKSGQISRRQASASVSQGANSESTVKNATNLGPVEMDAILPLESRPPTLLNMYNNYQPGELLTDRFGFIYDQRRKRRQREANAFKTPGGSNRVSIAETLSSLRSETSDGDDASDSQRQLQPAADSQPSPASASPENLEAGTVALRGWQDYLRVPTGPTELLSHTPSAGPIVALTTAGDNSPRNSAVAVDKRGSVSVNPNAQPSASTSTVVADRPEFSGISSDEPAIFSLSANENEPVKLLLEQLTELHDFLQRERTVRWNEFLRKVRAERRKDGEAAAAAAAASDRPLQSVDMPEASLADGEVVGISGLGNKGKVGRAKWREFRSLVLGGIPVALRAKVWSECSGASSMRVPGYYEDLVKGTGGCEPDPSVVAQIDMDINRTLTDNVFFRRGPGVAKLKEVLLAYSRRNPEVGYCQGMNLIAASLLLITPTAEDAFWLLTSMIEVILPEHYYDHGLLASRADQVVLRQYIAQVLPKLSAHLESLGVELEALTFQWFLSVFTDCLSAEALYRVWDVVLCLNVTSAGNNTPGTSTVNGASSTTEPNDADPSVSGNGGGSTFLFQVALALLKLNEQQLLTTCTSPAELYTYINHQMTNHAISIDGLIQASEALRNVIRREDVVARRAEALREMQEFTRGRPTSSGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X874</accession>
    <name>A0A317X874_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO94DRAFT_621190</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471490.1">
        <property type="nucleotide sequence ID" value="XM_025616983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X874"/>
    <dbReference type="STRING" id="1450535.A0A317X874"/>
    <dbReference type="GeneID" id="37119126"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000004">
        <property type="entry name" value="DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 22" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="21">
        <location>
            <begin position="7"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="762"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="248"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PWY94729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="798" mass="91165" checksum="CCB6643BEE48C029" modified="2018-10-10" version="1">MKFFIDDLPVLFPYPRIYPEQYAYMCDLKKTLDAGGHCVLEMPSGTGKTVSLLSLIVAYQQHYPEHRKLIYCSRTMSEIEKALAELKALMKFRAEQLGYTEDFRALGLTSRKNLCLHPSVKREKSGAVVDARCRSLTAGFVKEKKERGEDVELCVYHENLDLLEPHNLVPPGVFTLDGLLKYGEEHKQCPYFSARRMMPFCNVIIYSYHYLLDPKIAERVSRELSKDCIVVFDEAHNIDNVCIESLSIDLTEDSLRKATRGANNLERKISEMKSTDAEKLQNEYSKLVEGLREAEQAREEDQFISNPVLPDDLLKEAVPGNIRRAEHFISFLKRFIEYLKTRMKVMHTISETPPSFLTHVKDLTYIERKPLRFCAERLTSLVRTLELINIEDYQPLQEVATFATLVATYDKGFLLILEPFESEAATVPNPVLHFTCLDAAIAIKPVFDRFSSVIITSGTLSPLEMYPKMLGFNTVMQESYSMTLARRSFLPMVVTRGSDQAQISSSFQIRNDPGVVRNYGNLVLEFARVTPDGIVVFFPSYLYMESIISMWQGMGILDSIWNYKLILVETPDAQESSLALETYRTACCNGRGAILFCVARGKVSEGIDFDHHYGRAVINIGVPFQYTESRILKARLEFLRENYRIRENDFLSFDAMRHAAQCLGRVLRGKDDYGVMVLADRRFQKKRNQLPKWINQAMLESETNLSTDMAVATAKNFLRTMAQPFKARDQEGISTWSLADLERHLEKQRLEEERAQRQALANDANGAYNGVHNGVRNGAGPDEFDDDIDEDLMMLDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8F0</accession>
    <name>A0A317X8F0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine deaminase</fullName>
            <shortName evidence="7">ADE</shortName>
            <ecNumber evidence="7">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenine aminohydrolase</fullName>
            <shortName evidence="7">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAH1</name>
        <name evidence="9" type="ORF">BO94DRAFT_532916</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8F0"/>
    <dbReference type="STRING" id="1450535.A0A317X8F0"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000039">
        <property type="entry name" value="Adenine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF6">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="14"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="352" mass="39652" checksum="43B01A9DDFA3639F" modified="2018-10-10" version="1">MCQSTWHDFLRGLPKCEHHVHLEGCLTPELIFQLASKNAVQLPATPEYTSIETLTQRYGNFTSLDDFLHFYFIGMSVLQHESDFSDLAWAYFQKAHADGVHHAEVFFDPQVHQDRGIAYETIISGFVAGCQRAEKELGLSTRLILCFVRHLSVDSAKETYAKILDNGHFESDTVHGLGWSSSEVGPPKDMFREIYASARERGVRLTAHAGEEGDPTYISTALELGARRIDHGIRLVEDPVLMERIAREGILLTVCPLSNVQLKCVKEVGEVPIRKFLDAGVKFSINSDDPAYFGGYILDNYCAVQEAFGLSVEEWKVIAVNSVSESWIEEERKMELLGRIEDHVVRFAELVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8I6</accession>
    <name>A0A317X8I6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_610012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471356.1">
        <property type="nucleotide sequence ID" value="XM_025616599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8I6"/>
    <dbReference type="GeneID" id="37118742"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="322" mass="35840" checksum="C50E4D288F14B283" modified="2018-10-10" version="1">MENQESEDNILAECHDILLGVPGINFSRAGEFHDPNVTKVAPEAIPKAEPEGEPGMLLGLPVGYVTKDFINFETLQEDARAIQQALNTNKNQGNQWLLIRNLTDVAISRLASDESPIPDIGYCFEWDGSTGLLKIIHSSFLHEEIFTRLAGTIDHQLKYMNAPGGRFHKDTAYGTGQRGKSGDWVFTPPTRGLDDSGKSPSWPTLVFETGVSESYDKLVNNARWWFKASNNDVKIVLLILMGPDEVRFAKLRRKIDSDGSVHCERVVRVTESEIVGAPMVFPLVALYGVNRISVDGEERNVSLWKIEIGEEDFKGVVNVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X984</accession>
    <name>A0A317X984_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_581403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471820.1">
        <property type="nucleotide sequence ID" value="XM_025615402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X984"/>
    <dbReference type="STRING" id="1450535.A0A317X984"/>
    <dbReference type="GeneID" id="37117545"/>
    <dbReference type="OrthoDB" id="4526332at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="99" mass="10500" checksum="BCCEC45390ACC539" modified="2018-10-10" version="1">MPQPTPARKSLLHLLHGMVDLHSEPSAIPPLPTTTKTATGIPNESAPASNTDQDHKKHLAWIYPLVVRAVPVAGKEQDDGEVLQALGKVLHEVGGGGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9Q6</accession>
    <name>A0A317X9Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Distal membrane-arm assembly complex protein 1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_531145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471990.1">
        <property type="nucleotide sequence ID" value="XM_025610836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9Q6"/>
    <dbReference type="GeneID" id="37112979"/>
    <dbReference type="OrthoDB" id="6604875at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028036">
        <property type="entry name" value="DMAC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053092">
        <property type="entry name" value="Mitochondrial_unc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048:SF1">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15055">
        <property type="entry name" value="DMAC1_Dmo2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Distal membrane-arm assembly complex protein 1-like" evidence="2">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="96" mass="10464" checksum="4E93C282F2547B01" modified="2018-10-10" version="1">MAPPTENTGAWDVQPKDAKRALAEDAYDDCLSCRVTGSAAFIGLGVYSYYSGMKNLKMQEKTIMQSATKYKMASRQLGIATISATLVGMGLWRAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA14</accession>
    <name>A0A317XA14_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_125574</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472214.1">
        <property type="nucleotide sequence ID" value="XM_025605604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA14"/>
    <dbReference type="STRING" id="1450535.A0A317XA14"/>
    <dbReference type="GeneID" id="37107747"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="11"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="374" mass="40114" checksum="76926899DA770F64" modified="2018-10-10" version="1">MASTVDTPIPLWLDCDPGHDDAFAILLAAHHPSLKLLGITTIHGNASLENTTINATRVLEAIGRPEIPVYPGSKKPFCRPALHAPNIHGDSGLDGTELLPKASRAPITDQNPILAMRDALMAQPKGTAWVVATGTLTNVALLFATFPEVGEHIQGLTIMGGGVGNGFTTAPMSRLVGQENRIGNVTPLAEFNIYCDPEASQAIFSDPVVSSKTTLIALDLTHQVLATKSVRNLVRHGVDDASIEPTTLRQMLYELLIFFASTYEEVFGLATGPPLHDPLAVAVILSTLNPLYAKNHPDQVLKFDERDGERFAVDVITDGLHGTDVALVGSLGRTVVKDTPNAVCIPRGVDLDAFWNMINDCIRRADECNAARKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAC0</accession>
    <name>A0A317XAC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_343724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470231.1">
        <property type="nucleotide sequence ID" value="XM_025607054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAC0"/>
    <dbReference type="GeneID" id="37109197"/>
    <dbReference type="OrthoDB" id="5287717at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="66805" checksum="20C9489980E4BBC2" modified="2018-10-10" version="1">MARTEPIEMECVTQHLTFAGSPMILGNSISDISDSTGNLNSSDSTGNSDSNDSTGNSDRASNRSTSSNRSNNNRLDTQETRLESAMLYQISSMNRFYTRTIVLVFIPPLVAAYFVVIWLVLLRKGADPAVKFASISELWVFYSWFVICTFGIGWSKYGLAGVEVAMLQSRLVDKKTLYMHSGNSWSGPDGWISCLGRLLRGKESQVHRLWYFLSALSLLPFVALPISGLCMELSDGYIFSSSAPWVIGRQWDNFNNRQLDQISSRARSRWETGASAVLPGIGILHTPPHTRREKFNGLRNLPNIFPLDELPSEFFISPQARTPFDGSAWGLRIEYNCSIVRDASEFTIISDRSNIIKQPTSNNITERDVIVNAGSQGNVYVSNSRSGDSTRSHNLFAYIEMGVSNSSNQPPAYDGAELETVNILELALWQMRTQSGYEEETQGFPFDEGIDVPLKGMGQPFIQLPNGTFTNNETFFEAYNTSDALDDFASPDKKILYLAPPIGLRCNRLSTLGFAELAVKASTYHNFTRTQPPDFDIGREEGRTPIFGYTTRDILRYQYLMYFDSINLPPPRTVSNSVYYTRFLQAVSRILIPTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBA6</accession>
    <name>A0A317XBA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_580960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472560.1">
        <property type="nucleotide sequence ID" value="XM_025615358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBA6"/>
    <dbReference type="GeneID" id="37117501"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08864">
        <property type="entry name" value="SRPBCC_DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="3">
        <location>
            <begin position="151"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="619"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="661" mass="72125" checksum="7F0FF27FE79BAA8C" modified="2018-10-10" version="1">MPDHDLQTALQSLSPTTWSDIPTTNPAALRAYLSDLRTKAHLIIDSVPLPSAPSSSSSSDGDASQTGYADQPAGLIRPSKVVPTQPLINIPIANGDTTPTPTTNGGAPGVNDILKEVRKEWSKPIKITNARDNPLQIPIYKLPGADGKGHWFGRRSVHEGLGFDRWREKLSGEMGETLRRNEERVRRGKMPDQAVRGIGAERLVEGVDVYHVSAQFPKPTAARDFVSCIVTWEDGDGEDGSQAQEGGTGGGGRGKGREWMMVSRPCVHDDAPPVQGYIRGMYESVEFIREIPVEGEGMNPVEWVMVTRSDPGGNIPRWMVEKGTPKSICTDAIKFLNWACRDGEGRKSTDKSVGSQYDGEGEASSEEDSEDDFQYDEVEHHGLIASFAYLVNAGLERYAPQTVLDYLPTHSRQPSAQNVPETDKEVDEGKGADEPDGAEADDAASGKASISPSANSALDSSAEAGPDISALELMTKNKKGKLTSHEKQLAKLAERKRNVEAQLDRVRTDIQALRVTSPVEGSKRDKASTAALAATNDQPSSEPTSSPASSVHKGQSGKSADQDTARMQKVASGLFHEESKLLKQLSKIEKDQVKEASKIEARQQKHADKQEKWRSRAESDALRREVDVLKKEVDRLRAERKQWLDLIGSLQSENTRLAAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC30</accession>
    <name>A0A317XC30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_483113</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472830.1">
        <property type="nucleotide sequence ID" value="XM_025608910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC30"/>
    <dbReference type="STRING" id="1450535.A0A317XC30"/>
    <dbReference type="GeneID" id="37111053"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="14">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="13">
        <location>
            <begin position="286"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="15">
        <location>
            <begin position="606"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY96069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="766" mass="83146" checksum="5B188CA3530E840A" modified="2018-10-10" version="1" fragment="single">MEEGPAEMAGYTPLDVNIPPVPTTQVLTNLHWETLLALADTVIPSIRARGHDVDVSSTTHQTVTETQLESATSRLTATITQTTPQAAEVARAYLQESASSLPGFREGLQRLIADYVHHEGQNGLRFILTVLNTRTGSLLLTGSTTPIQNQPLAVREQIFSGWASSRLSPIRLIHRSLSAMFKTTWVVSSPTLPVALGFPRVPVHGKYAPGCWEYEFLQFPPGDHDEKGKEQPEILETDVVIIGSGCGGAVAAKNLAEGGHRVLVVEKSYHYPSQYFPMDVRTAPVSLFEGGASILTDDASLAIFAGSTWGGGGTINWSAALQTQAFVRKEWADESGLPFFTSAAFQRSLDRVSARMGVSAAHIRHNRQNRDLLEGARKLGYAAEAVPQNTGGEEHYCGYCTLGCSAAGKKGPTETWLADAAKAGAVFVEGFKADKVTFTTTDRERIATGVEGTWTSRNAYLARGQGDDAITRKVVIKAKKVIVSCGTLNSPLLLLRSGLQNWHIGRNLHLHPVLFGAAVFGEEIRPWEGSALTAVVKEFENLDGRGHGAKIETTVTLPPFFLPIFPWRGGLEYKLFCAKLSAMTSFIAITRDRDSGRVYPDPVDGRLRVDYTPSAFDRNSAMEALIASAKIAYISGAKEFHVSYADMPPFCRSEDQASSHDLTESDEGINNPEFQKWITQFRQSSPLDVEKAGYASAHQMGTCRMASTASKGVVDPQCQVWGTQGLYVMDASVFPSASGVNPMITNMAIADWASRNLSKKMRKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCG9</accession>
    <name>A0A317XCG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_581168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472786.1">
        <property type="nucleotide sequence ID" value="XM_025615380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCG9"/>
    <dbReference type="GeneID" id="37117523"/>
    <dbReference type="OrthoDB" id="4369211at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="442" mass="51122" checksum="788AD3722718E741" modified="2018-10-10" version="1">MRRHKNPTISDWVYRIREEFYTKHGDQIKAEFQSDNPQFSVTESLIQEANQAIRAENQKNKVDMERGVIPEGTYDRTWKQWQDLIHSDFVKDSTKKKWEYFEQVQKTFRQFNQQNELPQEWNLPREFAEQNFGPRPADLDAQQDSDLDSAIAYSESDSESDVESEADQALEGLDALESRMRKQYSSLSQGKVLYWWPVGTGTQVFVRYGTRKCPIYRVRAGSSQPWDECATELVLSKTPGNSKIVLKDGGGSRREVWKYSRADVQDILGVGWKVYDDDDDSSGNALLEIRPKQEYYPHTRILIRWKSGQTSLERRGFMRRITAGSSLNGDRVIYTKAREMETAYWGYDPEDYSEERSTDSDSDSSTAYSISSSDSPRTRRATVSRSRKRRGKSQKPITVDSDTENDSPHHASSTRRKAKGRNIDKQISLLTKQLKKLQATKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDK1</accession>
    <name>A0A317XDK1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_530004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473380.1">
        <property type="nucleotide sequence ID" value="XM_025610581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDK1"/>
    <dbReference type="STRING" id="1450535.A0A317XDK1"/>
    <dbReference type="GeneID" id="37112724"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000191">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16043" checksum="3A19162E4D47BB30" modified="2018-10-10" version="1">MSDPLLFEDTFTITSINSQKYDRVSRLSCNSTDNFTHFTLDVNSELYPCAVGESVSMALASTLSLDGKEDSGSKGWREVGMGENTLANDYDYVCHGKVYRFEEGSSQGNMAVFISFGGLLLYLEGPYKKLAPLRIDHVYLLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDW4</accession>
    <name>A0A317XDW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPP4R2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_531019</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471879.1">
        <property type="nucleotide sequence ID" value="XM_025610801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDW4"/>
    <dbReference type="STRING" id="1450535.A0A317XDW4"/>
    <dbReference type="GeneID" id="37112944"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="39997" checksum="749A67879AA5159B" modified="2018-10-10" version="1">MSLDEETLEVVANGGSMDYEKWPSMVEPLLDRLDHIIYNVFPMPRVPPEIQQSLNTTVPYAQNPNTTASSTTLQTPPRPTATSLHQTPASERIPDSQPQSSQGPSLPQPLEFHLASIKSTLRSLFATKPPHTIQRLAELIVRPTAHYRTLPAYIRAVDRVVCVTSGADIFPLQTQTSAAPQPNGAVLNGTESGLLFSDHGLGSDESLGGALLTPIPWLSNAAASPEREDESGAVMGDTSFPAQAAEGTGPDQTGTGVVPSTAETVETNGNEGVGGSPPPDALEDIPHARGPSVLGVEDLGLQDGKGVEMDLSSAEDGASELHTAGQQGQQQQTGLTQGDSQMSEEAAKLSTDGDGDIALEDAKAGGEETPGSETANKEQQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEI1</accession>
    <name>A0A317XEI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_507526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472818.1">
        <property type="nucleotide sequence ID" value="XM_025609619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEI1"/>
    <dbReference type="GeneID" id="37111762"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="33"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY96057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="320" mass="35294" checksum="A38037FFC1B9DACD" modified="2018-10-10" version="1">MTIFRTLRSSESEPEPEYGTKQLHDSEEAEVDIVFVHGLGGAREATWTINDVCWPQALLPQDLPKTRILTFGYDSRVVSFTAALSQNGIIGNAEDLCAQLSRYRTESGTRPIIFVAHSLGGLVCAQAVVAGNRSAPSDNTETVSKHIRGIVFLGTPFCGSEIASWVSRFHKVADYIFEINKSNISDLRSKSDTLQHLMEEFANVLRKRDNSDDSVHTTFFYEQRKTQNVMVVDRNSAAIPGRGDMISIPADHKHICKFGSRDDEGYGLVLGALKKMLVIVPVRKKEISPVFNFNNAGAAINNQAGQQTIHGGMNFGSFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEL4</accession>
    <name>A0A317XEL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_581384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471801.1">
        <property type="nucleotide sequence ID" value="XM_025615401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEL4"/>
    <dbReference type="STRING" id="1450535.A0A317XEL4"/>
    <dbReference type="GeneID" id="37117544"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="84"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY95040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="537" mass="58814" checksum="89CC72AA101D0B4F" modified="2018-10-10" version="1">MHAPETTPHPHTSGLAGKTFTSVRRKDGGQEGDAVNGDQRSLSSGDREVNTRVKTTAQGIPLVPQPSDDPDDPLNWSAFTKHAALVVLAFESFLVKFSATLIAPDALELANEFGVHKSTATYIGSAPPILNAITSFFWIPLSHRIGRRPVLLIGNLIALASAIGVARSQTYAQALSCRMVMTLGGSVGLSIAPAAISDMFFLHDKGSRMGVNSMLLVVGPYIGGVAGGSIAYSQALGWRWSMYIAAILYAVQFIAQVCFVPETTYTRDENGTAVPNPSEQKQNTFLSLLKFRIPAVPQHETWAQTFRKPYKMFAYPTVVLPSFWFSVANMTEVGNTAGFALNFGKDSRWQFNLAQIGFCYFSGVIGAGLGEIFGGPLCDMLAKYSIRRGQEWKPERLLHLVWTGLITISAGLLLYGLELEYGNSWASALTGIGLFTFGQELLVTVLLTYMTDCYPDDAAEVAIVFQFFFAIQTFHVPFYLPQWLEGPGGPKVPYIVFAALPVVLYPFCIWVFTWKGEQIRNRGPLLFKDGEPQSEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF85</accession>
    <name>A0A317XF85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 12">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_552051</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9 12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 12"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473178.1">
        <property type="nucleotide sequence ID" value="XM_025613571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF85"/>
    <dbReference type="STRING" id="1450535.A0A317XF85"/>
    <dbReference type="GeneID" id="37115714"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000028">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY96417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="396" mass="44906" checksum="7FFCC43463CFBAF8" modified="2018-10-10" version="1">MAEFVRSQILGTTFETTNRYADIQPVGLGAFGLVCSAYDMITRQPVAIKKMMKPFSNSTIAKRTYREVKLLKHLRHENLIGLSDIFISPLEDVYMVTDLLGTDLNRLLTATPLDGKFVQYFTYQLLRGLKYIHSAGVIHRDLKPSNILVNENCDLKICDFGLARLQEPQMTGYVSTRYYRAPEIMLTWQKYGMEVDIWSAGCIAAEMLRGKPLFPGKDHIHQFFLITEALGNPPDEVVERICTKTTLDLVKSLPSRQPPPWKSLFPGSDSDAIDLLGKMLIFDPEKRLSAAQALEHPYLGVYHDPTDEPVAEHQFDWTFSEVAHSIDEWKIMIYSEVVDFHNLGPTGQLAITEAFLSPDVSLSPEVLDPLNSPENQSMIVKTMDNLDQDIMQYLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGB7</accession>
    <name>A0A317XGB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_139927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472651.1">
        <property type="nucleotide sequence ID" value="XM_025605718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGB7"/>
    <dbReference type="GeneID" id="37107861"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="73" mass="7997" checksum="91CB0314BC274674" modified="2018-10-10" version="1">MSFWPMSTGGFFSSAATLTRNISLPSGEYVLSKHCRDSTRPMRLRSLHSWPSRCCGLACSTPSRGSPMFPGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGC2</accession>
    <name>A0A317XGC2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_562497</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472661.1">
        <property type="nucleotide sequence ID" value="XM_025614290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGC2"/>
    <dbReference type="GeneID" id="37116433"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="241"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="439" mass="48804" checksum="91AC03AD4FAA3B7D" modified="2018-10-10" version="1">MALQHQNLESLGSTISGLSKSLADQLKYLNQPEPSFAADGPAALPSTIEVQGIRMKLLEALEGLHHLVTGPSDFWFQESMFLNHELLTFDVFNNFNFWDAVPLNDSARYADIAKSTNLPEQIVRRFLRLAFGIHVFAEEASGSDRVVHTAASAHIARSPFVRSFVSHNMEDVRPAATVGVEALRKWFVGHAEPPEDVATCAVPLATDNGLQRGTDLWEYLETFERPDQPKGFRAERFAQAMQGLRETSGTMTEMSLNEATVVDLGGSAGHISVILAENYPKLKLVVQDLAAAKSAFDANIKTSMYETRIQFQTHDFFQQQDVPADVFLLKSVLHDWSDKYVLQIVRNLLGVLQPGNHLLVFDFVVPAECDGENQSTMPLPVKKSIAAMDLQMHVACNSKERRVEDWAEVIQRADTRFKLRGAHLPSGSPLGILDFVFQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XH21</accession>
    <name>A0A317XH21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Non-ribosomal peptide synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_18351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473489.1">
        <property type="nucleotide sequence ID" value="XM_025605992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XH21"/>
    <dbReference type="STRING" id="1450535.A0A317XH21"/>
    <dbReference type="GeneID" id="37108135"/>
    <dbReference type="OrthoDB" id="408177at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05930">
        <property type="entry name" value="A_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF6">
        <property type="entry name" value="BETA-ALANINE-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="532"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113220" checksum="2C7D74D50F3E4161" modified="2018-10-10" version="1">MGSWASEGLAHALQRQVELSEATVAIRSGDHALTFKELHNRALHLAEQIDRKRLGTEFPVSILAPRGINHVLAQVAVIYAGGSCVPLDVKQPDDYLDGLLAHLHCSLVITDPEHQGRLVAYDHLVADHEASTPRIRAVDDDAWRPYPSVEGACSHIFHTSGTTGKPKAVQVLGQGILNLASSGTYLAERGQRFAHVGNVSFDAALFEIWVSLLSGCSLVVIPQEVVLEPVAFSDRLRSEKIDVMLLTPALLTSTANAIPNAFATLHTLYTGGEAINVPAVRTIFENGAPQRLVNLYGPTECTVYCLCHKVSAADVEDNHIPLGHPIDNMDAFVVDDDLNPVNPGEVGELLVRGTGVSRGYYGEEEKTAKAFVRAAHLAGSESASSHCYRTGDLVRRNAAGSYDFIGRKDNQVKIRGQRIELEAVELLLLETGLVRAATVLKVQPEDSTLPALLLAYVIPASSTVDANAIIREFIRRTPHMVPRIEFLEEFPLRLTGKVDRKLLEHQYLDKMRKARRSLVSSGKKGPRGQSFPALLEYLEVLWREILCLPVDRLHNSDDFFHIGGTSLQAATLVARVRQALAVELPSAALYEHSTLEGLARLVQSLQAGTVHDAHRQTEEVWREDCELGKDVTPLPGALPDWKSPDEGRVFLTGATGFVGAFLLYELLQMPAVRRVACLIRAKDVVTGMARLRQNLAKYQIRLEPGMEDRIFIVPGDFGQPNIGLDPYLYELLAAWSSVVFHLGAHVNYVQPYSSHRAANVHGTLRMIEFANSQRPKMLHYSSSIAAYGPSGFVLGARAIPEDARPREYMRALEYDTGYSQSQMVAETVIWNAIDNGLPVAIYRPGFVLGHTQSGISNPDDFAGRLFKSCLEMGCYPILPAQRKEFIPVDFVVGALLHIAASPAKLRKAYNLIQPRHEAAIDMVTTFKILNDLSPTPMQGMPYADWVRRFSLELRDPLHPLIPMLQEKVLGDLTRWEIQEHMAVYGTDNLRQALADAPGLLYCEPMSALFKRYVTQWMPSQLPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UTD1</accession>
    <name>A0A317UTD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_540896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000060">
        <property type="protein sequence ID" value="PWY65274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461399.1">
        <property type="nucleotide sequence ID" value="XM_025613015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UTD1"/>
    <dbReference type="STRING" id="1450535.A0A317UTD1"/>
    <dbReference type="GeneID" id="37115158"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF127">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016300842" evidence="3">
        <location>
            <begin position="23"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY65274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="520" mass="56178" checksum="AC231E3A5071E8B6" modified="2018-10-10" version="1">MLSSRQLVALATILHAATRVSAQDLKEQVWAVFAYTLYGDRVPTALPRPNILTPYGANGLYAAGSAFRDRYVAIHSTDVSPSTRIESISSYALEDEDLNILSTTDPSVIASAQAFMQGLYPPLNETYDVQYPDPSYLMANGTYATAPMGGYQYPRIVTVSSDDPQSVVVAGQDNCFLHQITDADYQLNSGTQQIIQESAAFYNRLYDQALSGDFDRSSVNYANAISVSEFLEYQLLHNETLLLTVSQEDILLARWYADQYTFATNGNTESSGAIDSGAVRTIAGQTLAGHILDAFDTNVLYRGSSGKMTLLFGGYEPAVALTSLTQLASPGDGNFYGRPALGASMTFELFSLENASFPTYPDPSQLYVRFLLRNGTTSPEFQSYPLFGHSPSNIDIPYTEFKAEMEAFSLNSTEEWCLMCDSKSVFCPGVLSDESGASASSKTKPASKGMSPVTAGVIGAIVTLAVTGLVALGGFLLLGVRMHRRRRSSLEEIKGGIALGSDSNLALREHAAPPAKTMKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYW5</accession>
    <name>A0A317UYW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA exonuclease 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ribosome biogenesis protein NOP53</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_503916</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461907.1">
        <property type="nucleotide sequence ID" value="XM_025609494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYW5"/>
    <dbReference type="STRING" id="1450535.A0A317UYW5"/>
    <dbReference type="GeneID" id="37111637"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Exonuclease" evidence="14">
        <location>
            <begin position="538"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="223"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="437"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="279"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY67263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="733" mass="83488" checksum="DCFF46107361DB12" modified="2018-10-10" version="1">MSDPVGAPKQYKQPSRKGKKAWRKNVDIDEVQEGLRVLKDEEIKGGLLSEKPSDELFVIDTKGSSEIRDAYRKKHKPLKSEEILAQRSAIPGVDTRKRLNSKVTDGVIEPKNKRQKSDWVTRKDWLRLKQVAKEGNPVNKPAGDALYDPWGDVEDATPVVDPQFDFLEKPKPKVEPVTLKQAPISLAANGKPVPAVSKPNAGISYNPTFEDWDRLLQEHGEKAVEAEKKRLEEERKEEERQRMIAEAKDDDGQVRSDDESAWEGFESEYEKPEWLNKKRPERKTKTQRNKIKRRKEAERQAKWEAQMQKKESQVIQSNAATIGIQEEEFDRAEQSEDSSSDESSEEGDDTALRRRPLGGKLHAPEKRLEVVLPDELQDSLRLLKPEGNLLDDRFRTLVVQGKLESRKPITQAKKPKRKITEKWSYKDFKVPGLNWKKLQGTLKKDSVPATKRKSSDRETQDGVVKKRKTDTFEGKRKLERPQIALKRKRMSQNGTDGGDDGAQETTKKSTSRRNSTAAVAESKPKVNEGRSTTTELGKYVAMDCEMVGVGPNPDHDSALARVSIVNFNGDQVYDSYVRPKEMVTDWRTHVSGILPKHMIEARTLEQVQKDVSNILDGRILVGHAVSNDLDALLLSHSKRDIRDTSKHAPYRKIAGGGSPKLKILASEFLGLNIQDGAHSSVEDARATMLLYRRDKEVFEREHLKKWPVRVVVEKKEDGEDQKKKKKKKKTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZ88</accession>
    <name>A0A317UZ88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_479490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461709.1">
        <property type="nucleotide sequence ID" value="XM_025608746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZ88"/>
    <dbReference type="GeneID" id="37110889"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY66511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="340" mass="38513" checksum="51159A64B348C562" modified="2018-10-10" version="1">MAHTRMRLLLAVILLFILTCLLAPFLWNLYLLLRLPFVWKGSSTDAIVTQEHDAFDPTFAAYDSSYSTADSGLPVLIPARLHHVHLGPEPIRPEWKTARDECLAQHPTWEFFLWDDRNATRFVQNHYPHFLPTWDSYTHLVQRVDALRYMILHTYGGAILDFDLACKRPLEPLRRFDFVAPAANPVGISIGMMLSSPNNTYVGDLVRNLPNFNRRWSLLPYITVMFSTGCHYASTIYTMQRNTSNLRILTGPPENPKLHMLNGLVDTPLFHHLGSSSWHEMDAKLIKSFAGFDQRLSFGMVLVAGAGAMWAMGLCVSRVRRWGGQGRKGVGEGCGGIWGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZL8</accession>
    <name>A0A317UZL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_339605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000058">
        <property type="protein sequence ID" value="PWY65380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461446.1">
        <property type="nucleotide sequence ID" value="XM_025607030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZL8"/>
    <dbReference type="STRING" id="1450535.A0A317UZL8"/>
    <dbReference type="GeneID" id="37109173"/>
    <dbReference type="OrthoDB" id="20473at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037830">
        <property type="entry name" value="ZZZ3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705">
        <property type="entry name" value="ZINC FINGER, ZZ DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22705:SF0">
        <property type="entry name" value="ZZ-TYPE ZINC FINGER-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY65380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="255" mass="27619" checksum="DACA8E6141E3DDD9" modified="2018-10-10" version="1">MQPSEETSETQPGRPGTPPRPPYSPVTPVFAHLAPVTVPGNGAPHPIVPPAASPSPTTNVPPYGSDFPPPATEPVFVPEPAPVPISESENPDAIALRSALSILQLQKQQSVRDIQTLEKFKRAAAEDPEGFADELVAGNMSAKDPGGFINFTQNDKDSDDGDAEIPRKRVLSGLGPMPTPQNVVRMPPVNWAKYQIVGDPLDKMHEEQRVRPFPGEPRLSSQKAPEYLIASPLRPLIDPLESPSKLRKAHKNRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0Y5</accession>
    <name>A0A317V0Y5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_528606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461675.1">
        <property type="nucleotide sequence ID" value="XM_025610430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0Y5"/>
    <dbReference type="STRING" id="1450535.A0A317V0Y5"/>
    <dbReference type="GeneID" id="37112573"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="27"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="520"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="527"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY66477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="545" mass="60133" checksum="C2F16CEC18EA0033" modified="2018-10-10" version="1">MFTINNDERARWKITSRLQQKPLLIAINCLAGLAIFFFGYDQGMMGGVNDSAAYVTRMGLGYTANGSVTVTNTLLQGGIVSVYYLGTLVGCFLGGHVSDRYGRIRSLGFGAIWGIIGAALQCTAMNPSWMIVARLINGIGTGVLNATVPVYGSELADYESRGQFIAMEFTLNISGVAVAYWLGFGLSYIDHGESNFQWRFPIAFQIVFLLLLVIGCWVFPESPRWLCMVGRREEALYVLRRLRGTENEAAALQEMREIEAIVEMEASGDSITYFHMLFGLGNEDWHIARRVQLVIWLQILQSWSGIAGVTMYAPTIFKIADFDSQKTMWISGLNDIFYTLSTLICVFTLDRIGRRWTLWWGAAGQAIAMFLAGGLSRGGLTHPQSQAAWGIAATAMVYLYTFIFGATWLTVPWLYPAEIFPLKVRAKGNAWGVVGWSLGNGSLTLALPYIFASIGANTLHVFGAVNLISIPIVWALYPESSQRTLEEIDLLFAAKSPWVWTAEANFKALLAENPELGAGGRRSSMNEAEKGLKIETEHAETIASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2U4</accession>
    <name>A0A317V2U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-L-fucosidase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_570116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461834.1">
        <property type="nucleotide sequence ID" value="XM_025614779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2U4"/>
    <dbReference type="GeneID" id="37116922"/>
    <dbReference type="OrthoDB" id="2848340at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000028">
        <property type="entry name" value="Alpha-L-fucosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF0">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21307">
        <property type="entry name" value="Glyco_hydro_95_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="3">
        <location>
            <begin position="261"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha fucosidase A-like C-terminal" evidence="2">
        <location>
            <begin position="684"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY67112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="768" mass="84191" checksum="BF17A08B86926B26" modified="2018-10-10" version="1">MSIFRRRANNFTSTLPIGNGRLGASIWGTAIENITLNENSIWSGPFINRVNPNAYAALWPVRTLLAEGNISKGNDLTLDDMVGIPDSPQSYSALGALRLDFGHEEAWVQNYKRWLDLSTGVVGVEYGYKGVGFRREYVASYPDGVVGMRLSSSRAGGVDVVCELVRDRWVVGNTATVVDGHGVLALTANASDQADPIRFTAGARFVADGGRIVSNGTAVVVRGASTVDIFFDTETSYRYSSQAEWQAEITKKLDAASRAGYVAVKENAIADYSALSGRVDLNLGSSGSAGNLPTDTRLVNFRTDPDSDPELVSLMFNFGRHSLISSSRASESPALPANLQGLWNQDFDPAWGGRFTIDINLEMNYWPAEVTNLADTFSPFIDLMDIVKSRGLDVAESMYHCSNGGYVLHHNTDLWGDAAPVDNGTEWTMWPMGAAWLSANLIEHYRFTRDETILRARIWPLLQSAARFYYCYLFPFEGYYITGPSISPEAAFIIPGDMSIAGNEEGIDIAPTMDNSLLYELFQSVIETCEILKINTTDCTNATSYLAKIKPPQIGSSGRILEWRLDYEEADPGHRHMSPIFGLFPGYQLAPLVNETLAAAAKAFLDWRIAHGSGSTGWSRTWTMNLYARLLDGDQVWNHTQIYLQRFPSPNLWNTDSGPDTVFQIDGNFGFTSGIAEMLLQSYEKVHLLPALPTAVPKGHVFGLMTRGNFVVDMVWEGGVLSEANITSRSGSVLDIRVQGGVDFTVNGEGYTGPIGTNIGKVYTVVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V432</accession>
    <name>A0A317V432_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462348.1">
        <property type="nucleotide sequence ID" value="XM_025612851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V432"/>
    <dbReference type="GeneID" id="37114994"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22582" checksum="E07C07B4344E60FF" modified="2018-10-10" version="1">MKLIALPDVQETSDVACDTGSDPEVLRKEMEENNVPIDLGLVHEGWNNKQGKYAPTHKAIKERARAARRWLKARPEKEIVIVTHGGFLHYFTEDWEDSSQYQGTGWVNTEYRTYEFTKEVHTDDLEGYELDGDNATLVETLESRQRRGKSGPMSDREQQKTLYKIGTQGWDDQGLQLSIAEREAAKVPEGKEVNGTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5P5</accession>
    <name>A0A317V5P5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_421845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462462.1">
        <property type="nucleotide sequence ID" value="XM_025607408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5P5"/>
    <dbReference type="STRING" id="1450535.A0A317V5P5"/>
    <dbReference type="GeneID" id="37109551"/>
    <dbReference type="OrthoDB" id="2999773at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY69634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="173" mass="19751" checksum="AEADAE0087819066" modified="2018-10-10" version="1" fragment="single">IPTKPPTPNSLLLELHIFNGHPFKDHWAYWIPSPSDPNIGVKIHATGDMRNGFIFEIKRSHNLRTSPDIPTKRIPLQWLDERYIDEKAIFNDGVEKIDYRPVCGFEEMLYGVEVPGKTLNSVADGGEEMGKGRARRRVVQRDCQTWIVESADRLVREGVVGREGAEFVWGVKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7G4</accession>
    <name>A0A317V7G4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_303274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462092.1">
        <property type="nucleotide sequence ID" value="XM_025606763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7G4"/>
    <dbReference type="GeneID" id="37108906"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016233938" evidence="1">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="159" mass="17863" checksum="60E1BD1E69EBE65B" modified="2018-10-10" version="1">MSRNKSKHHRAGGLLIIHLIHVTGGVAHTPLASLLGLETISLTSTFPKSRDTGDRGGVEKTSFTRSSHYARSLFLSPRRLSAQNPPSPSLFLSWLSPRERSVVSSLPVILEWSRKGTDRGGVEFWYWQARLRLSCWDLHVAMVQDYPLLSTLTQSRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8M2</accession>
    <name>A0A317V8M2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ent-kaurene synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_628480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462479.1">
        <property type="nucleotide sequence ID" value="XM_025617486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8M2"/>
    <dbReference type="STRING" id="1450535.A0A317V8M2"/>
    <dbReference type="GeneID" id="37119629"/>
    <dbReference type="OrthoDB" id="2343925at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739:SF25">
        <property type="entry name" value="(E,E)-GERANYLLINALOOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31739">
        <property type="entry name" value="ENT-COPALYL DIPHOSPHATE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="62997" checksum="22D2631F9FF2ED55" modified="2018-10-10" version="1">MQLEGNSVRQLARSLLERLVDAHDPRYGFGTMTCAIYDTAWLSMIPRTEQGLTEWLFPKCFFFLLDKQQPDGGWEATASPIDGILNTAAGLLSLCKHRETLYQISMSEHDLNERISLGRKALLALLREWEIYETLHVGFEILVPALLDSLEAYDMEFQFRGREALYNIRDVKLSMIDLQSLEDRTKPSHSILHCLEALYGHINFDKLAHHKVCGSLMASPSATAAYLIHTSSWDGESEAYLRHVLEHGEGRGDGSVPSAFPSTIFELTWVLSTLAAAGLSEIQLRGEALTRALNMIKDEFHAQLGLMGFAPQIQPDADDTAKGITCLNMLGVPASASGLVKSFGQGKWFKTYSEERNSSISTNCNALVALLSDNIHIQFYSPVIAKVTRHLCETWFQSISIQDKWNISSYYTIMLLAQALSRVSERWRCGELSSPDDHELYEEQAPLVLFQILIHILQGQDTGGSWDGSMEVTAYSILAIEAFKGTAHAQLLDKQIHDALRGGRSFLVRRFRVQQHPEMLWIEKVTYGSSAISEAYVLAALHSSSMVYYRATTPEPPQLGAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8X0</accession>
    <name>A0A317V8X0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_628221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462707.1">
        <property type="nucleotide sequence ID" value="XM_025617467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8X0"/>
    <dbReference type="STRING" id="1450535.A0A317V8X0"/>
    <dbReference type="GeneID" id="37119610"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016319448" evidence="5">
        <location>
            <begin position="27"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="49"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY70813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="494" mass="52478" checksum="52EABFBDDC0A8A50" modified="2018-10-10" version="1">MSLNATGPSNLSGACCLALWSLLGAAKVAFPGSQLYNLSRSSYFSQQEAEVQPLCVVAPSTVDDVSTALKSITSIAASLPDEERSTCDFAIRSGGHAPIAGAANIERGVTFDLRDLNAIELSSDRTIASVGVGATWGKVYAILDPLNRSVAGGRAAQVGVGGLTTGGGISYFSPRYGWTCDTVQNFEVVLANGTVVNANADENPDLLVALRGGSNNLGVVTRVDLTAFEQGPLWGGAVSYSVDTIDQQLKATAEFSIAETYDEYSSLIAIYTFSSAHAATIINSIKYTKPEENPPAFQPFTEIPSLQNTLRIASLSDISAEEGSSSPNGKRQLATVTTFESSLPMLNATYRHWNTSLAAIQGVPGIVWSFYLEPLPPSIYARAGTDNSLGLSDASGSLMVALLGAIWNDDADDEQIEKVSRELLTAIENDSRDMDAYHPFVYLNYAAPWQDPIASYGEASVERLSRVARDVDPRGVFTANVPGGFKIPGDRSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VB41</accession>
    <name>A0A317VB41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_539531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462972.1">
        <property type="nucleotide sequence ID" value="XM_025612718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VB41"/>
    <dbReference type="GeneID" id="37114861"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY71574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="90" mass="10005" checksum="9E74066D72B8BB25" modified="2018-10-10" version="1">MKETIRLVVSVVSLHHHYFSTQSFPPSTPPRQEKLDPSTWDTLGPETVLFTDFSPAWPLMLNLLADQLSFLLRTSPSGLRAKDAKVPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCI5</accession>
    <name>A0A317VCI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_590387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462428.1">
        <property type="nucleotide sequence ID" value="XM_025616019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCI5"/>
    <dbReference type="STRING" id="1450535.A0A317VCI5"/>
    <dbReference type="GeneID" id="37118162"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="94"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="274" mass="30630" checksum="574AB02E53C05463" modified="2018-10-10" version="1">MANASPFSPSLLTEAPSDISGFGVSQVEMNRRLERYTTTSQADDTVEFLRIVFQQLPEDGTMNLAVDIYSCDTDETLRQLVRSFETGLLFPMKAFALEAAHIIPFALGAYRNSNERAQNCVIWANILRYFPSLRSRLGFISDEINRHENVMMLEAGIHREFGRFCLTLVPTSTENTYTVKTYQGFSTLYNIALPTNGRVVFISHDNRYQLPHPLLLQVHNAVAHILHMTGRGGKAEKLKREYDDSGLLAPEGGSDVESLLSLSTLGLLESAGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDY2</accession>
    <name>A0A317VDY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_265564</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in maceration and soft-rotting of plant tissue. Hydrolyzes the 1,4-alpha glycosidic bonds of de-esterified pectate in the smooth region of the plant cell wall.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462877.1">
        <property type="nucleotide sequence ID" value="XM_025606517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDY2"/>
    <dbReference type="STRING" id="1450535.A0A317VDY2"/>
    <dbReference type="GeneID" id="37108660"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF13">
        <property type="entry name" value="ENDOPOLYGALACTURONASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016333913" description="endo-polygalacturonase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="14">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY71122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="372" mass="38821" checksum="A901E23D4316DDBD" modified="2018-10-10" version="1">MPSVQPLICLATLAGAALVSAAPAPSRASEFAKRSTCTFTDAATASESKKSCSSIVLKDITVPAGETLNLKDLEDGTTVTFEGTTTWEYEEWSGPLLYISGKDITVTQESGAVLNGNGAKWWDGKGTNGGKTKPKFFYAHDLDDSKISGLKIKNTPVQAISVESDNLIIEDVTIDNSDGDSEGGHNTDGFDISESTYITITGATVKNQDDCVAINSGENIYFSGGTCSGGHGLSIGSVGGRDDNTVKNVTFIDSTVSDSENGVRIKTVYDATGSVEDITFSNIQISGISDYGIVIEQDYENGDPTGTPSNGITISDVKLEEVTGSVDSDAVEIYILCGDGSCTDWTMSGVDITGGKTSSKCENVPSGASCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VE74</accession>
    <name>A0A317VE74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Translation elongation factor eEF-1 subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_526212</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462969.1">
        <property type="nucleotide sequence ID" value="XM_025610344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VE74"/>
    <dbReference type="STRING" id="1450535.A0A317VE74"/>
    <dbReference type="GeneID" id="37112487"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="91"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="6">
        <location>
            <begin position="251"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY71571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="412" mass="46200" checksum="9DC4F12A85B8F152" modified="2018-10-10" version="1">MSFGKVYGLPENGRTIAALVAAKANDVEVELVKTEANSTASFNQSAEYTKISPVGKIPAFEGANGYTLSEVIAIAVYLTSQNEKTTLLGKTKQDYASILRWLSFANSEVLPRFGAWFRPLLGLDAYNKKNVEDAAKAALKNAGVLNTHLTANTYLVGERITLADYFTAALLTRAFATVLDKKFRDENVAITRWYKTIVNQPAFKAVVENPVFVEEAIKYTPPKKEEKPKKEAAPAAAAAPAEPKPEAEKKPKHPLEALGRPTFILDDLKREYSNEDTRPVALPWFWKNYNPEEYSLWSVNYKYNDELKLTFMANNLIGGFHARLEASRKYLFGAQSVYGANYACVIQGVFLVRGQEFAPAFEVAPDWESYDFKKLDHTNAEDRKLVEDQWAWDTPIVVDGKELHHVDGHVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VH65</accession>
    <name>A0A317VH65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C-x8-C-x5-C-x3-H zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_569211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463195.1">
        <property type="nucleotide sequence ID" value="XM_025614728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VH65"/>
    <dbReference type="STRING" id="1450535.A0A317VH65"/>
    <dbReference type="GeneID" id="37116871"/>
    <dbReference type="OrthoDB" id="2270193at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057654">
        <property type="entry name" value="Znf-CCCH_tandem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25542">
        <property type="entry name" value="zf-CCCH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25543">
        <property type="entry name" value="zf-CCCH_tandem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="2">
        <location>
            <begin position="73"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Tandem CCCH zinc finger" evidence="4">
        <location>
            <begin position="394"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY72242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="455" mass="50965" checksum="8A5A35C3EA8B5AC9" modified="2018-10-10" version="1">MTAPAYFERYKQLASIEQDKNILIEELLQRVTELESAFQQEKLDHERETRFNRDIQLHEMDLMQQIARIKAIMDREPFIVVLLDGAGILFRDEFLQAGEEGGKIAAKKLSISLKNYVFGNFPGIEIPKIIARMYVNIKALGEICVRGGITADPSSVEEFARGFNSHPLFDLVDTGVDSAHEKIGEAFKLNLYNCHCHQIFLGCSDDSAYAQILVDSLDELDLLGRVSLIEGTPFGEDLNSIKASYRVSRFPEIFRDTKITPILAPWKAAVASKPPPVLTPSPNQRAVSLSRSSTNTSTNASTSLSSTSARPPSPGEFQVVQSKSVASARPKIVERNKYGQRVDRLDFKSIPRDDMNRLKKLKLCNLYYLLGECTVDNCQHDHSRKLTKNELSILTAIARMTPCRYGLDCDDPECTYGHRCPHTDPGKKDCYWGSSCRFDPAAHGVDTNIVKVTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VI12</accession>
    <name>A0A317VI12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_539199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463296.1">
        <property type="nucleotide sequence ID" value="XM_025612650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VI12"/>
    <dbReference type="STRING" id="1450535.A0A317VI12"/>
    <dbReference type="GeneID" id="37114793"/>
    <dbReference type="OrthoDB" id="5425130at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="260" mass="28497" checksum="4BA6A4CA539C106B" modified="2018-10-10" version="1">MAILDKENRSRGLRVPSFAMKGFKQKSTDSLPQKGAEPVQAPETTVTPAQTYSVPGDAARQQESKSPPLTPLPSAVQPPAFNAPSPRQDAHLPLAPAASYTPPPRAYQAYRPPVSSVPVQRTPPSSEEDPDRVIPRTEMDEPLEDFIPEPEPELDGTGAPIEPVSSEENNGPWTPPDIEPVAAPLNKLHFACYQDHRSMPPANNVWHTLPCMTCLKFDREVRHRCVFCCLRICAGCFQALQACPNRSLTQLMESITAAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIV4</accession>
    <name>A0A317VIV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_559946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463416.1">
        <property type="nucleotide sequence ID" value="XM_025614110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIV4"/>
    <dbReference type="STRING" id="1450535.A0A317VIV4"/>
    <dbReference type="GeneID" id="37116253"/>
    <dbReference type="OrthoDB" id="442243at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF1">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="47412" checksum="7078E3A6F7123231" modified="2018-10-10" version="1">MKKTLLLVFIHGFKGDDDTFRQFPGRFCALLSRSLPAVQVATAVYPKYETRGELKECVSIFREWLQNKVIDLEVANRTASPTVDPSVHVFLVGHSMGGIVAAETLLLLASEQPIPVTSSAGAPTNPLADSGTAVGADSFMFPHIQGVIAFDTPFLGIAPGVVSYGAEGHYRNVTSAYTALSEVAGLFGLGGNGSPNKAASTEQKSDPNKSLPPSAPSSSSSTDAAATPSWQRWGRYAMFAGAAGAVAAGGAAAMYSQRERLTDGLGWVSSHLAFVGCLARSSELRRRLALLSDVQKERGIGCTNFYTCLGKNASALVENRNAGTSSFSQKIIRSKNRTFCSLPAEVESSGFSQQDIRWARAVNDKAADEIKAHISMFLPNENPAFDLLVADACKVLVESVDKGWYATATGPIEEVDGDIPRADTDRTKVQADSRFMDGDDVVVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJI0</accession>
    <name>A0A317VJI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_499888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463659.1">
        <property type="nucleotide sequence ID" value="XM_025609397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJI0"/>
    <dbReference type="STRING" id="1450535.A0A317VJI0"/>
    <dbReference type="GeneID" id="37111540"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF389">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016419123" description="chitinase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="32"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY74466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="677" mass="74548" checksum="33ECB0686D66246D" modified="2018-10-10" version="1">MLVGIVLTLLASFRVLPSVMAATCDITSHSITRVIGYYNSGAVSRPCSVMMPYFFPQGIYSHIYFASGNIHPDTFEVIPLANRDKRLYTYLEGLHNRDFGQELWLSLGGWAFSDNDAPTATTFSDLAAADITQQNVFFTSLIRFMHTFHFSGVDIDWEYPVAADRNGRAEDYTNYPIFLANLKAVLDDYNFGLSITLPPSDRYLQHYDLASIEPSVDWFNFMSYDLHGTWNMGEEWNGAVNAHTNLTEIKNAFDLLWRKNIPPFKVNMGMAFHGRTFTLADPSCTEPGCTFLSGGDEGDCSLSAGTLFNSEINRMIHQDNLNPTLNSDVAVKTIVWNTDQWVAYDDQDTWKIKANFAKSQCLGGVFVRSVDEDDRNHTFSKGLMEALGNEYNLDIKTGLTKVAFNELSTTTGSRSQSSHKQYCRFVNCGASCPNGFTEVTRADQPSQIMQDSTSCPLDSDQTQKLCCPTSSKVPICQWRGFDDSGKCTGGCSGDETELGTSTDGCHSGYQSACCSITKSTEPWSQCQWTSCENDETCPSGYHFVAGSRQGWGGRKSCSGKQQYNYCCSGSVPGIFSRCEWTHPSGDYCSASCPSDSIRVAGQSIFSSGTDQTVDTLGCLHGNEAYCCSGAQQVSSPKSSLSSVSQEQSAEEFSGYLQKFLANPVIPEGWAGRMAEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VK12</accession>
    <name>A0A317VK12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_589569</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463477.1">
        <property type="nucleotide sequence ID" value="XM_025615953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VK12"/>
    <dbReference type="STRING" id="1450535.A0A317VK12"/>
    <dbReference type="GeneID" id="37118096"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000024">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY73212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="183" mass="21157" checksum="F2908B063A41F791" modified="2018-10-10" version="1">MGLTFSKLFDRLWGRKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRIVEAREELQRMLNEDELRDALLLVFANKQDLPNAMSPAEITQQLGLQSLTRRPWYIQSTCATTGDGLYEGLEWLAETLRKTNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VL01</accession>
    <name>A0A317VL01_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_234438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463549.1">
        <property type="nucleotide sequence ID" value="XM_025606317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VL01"/>
    <dbReference type="GeneID" id="37108460"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY73797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="73" mass="8203" checksum="45CFE444D1F2C0C5" modified="2018-10-10" version="1">MGAGVGMKVRVLKERNPRPTKVMIPPGKNGRRVCGVGSSESFVLHHHFLELDLPTDLPTCMHTDEYVHPQLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLK5</accession>
    <name>A0A317VLK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_559525</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463853.1">
        <property type="nucleotide sequence ID" value="XM_025614074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLK5"/>
    <dbReference type="STRING" id="1450535.A0A317VLK5"/>
    <dbReference type="GeneID" id="37116217"/>
    <dbReference type="OrthoDB" id="6486656at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="617"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY75226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="809" mass="90043" checksum="36DC962E74669AFA" modified="2018-10-10" version="1">MFRHFQMPPPPNGNTAQSDAAGRPKDRTRRACERCRQMKIKCDGATTCNHCRTSFNDCVYPEPRRKRKASPHFDRLQELEKRVKAMEESYQTISAVKDSPPSDKSSTQPHPLSATGANDPDTDPTDPRAQARPSQGEARFGVSSADRAFIERLKAELGDWPGADFDSRLRIREKPGVKLFQSANPAPRVVALPPRERAEHLINIALDASVLYHVVHRPTFDSAFELLYSLDRSDYGEGEMRHIPLVYALMALGCLFERVADGSSESGDDMTAERTNYFATCRDLVDLHDCSDIVTLQAIFYMNLFILSTERLSPCYTCLSHAFSLAVRMNLQLPNSRDSLIVAEIKRRLFWSLRQLLMVVASMCGYPQPIRSTEVDIELPLDLDDNDLKSTRISQSLQDPALIRSMSGSVALLKLHNILDRIVHELYPSGGVRRKTNSGSMSHLVSNEIVTQLEGELQKWAASLPLGYKLGRSRYAPHLEKAKYELWMTYSHVQILLYRPFLHYFVDSTEGNGHAEHGFHKYASACVDASRNLIHLTEDMYRDGLLYGAHWRIAYMVCTAGLSLVYVVVGSKSPDTVKALKIDLNTAKRMLMCLTPYSSHSRRLHVALTVLTATFTKSDHGSQSQSPNDTVEVGSERPSEPYTGGLAEHAFDASAQRNQKYIGPVMEETVAPDPNVYPRGMETHTSQATATETFPLVPVSQPPMTHLDSTPVASGYAVPSLPASVPGATMATPAPENATPQSAERVMEALSGGAPTYGPEPGLSDQTYYLEARPFNLQRPTEGEDYLFGREFGDFDGMTGDLLSFDYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLL8</accession>
    <name>A0A317VLL8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_538584</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463891.1">
        <property type="nucleotide sequence ID" value="XM_025612524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLL8"/>
    <dbReference type="STRING" id="1450535.A0A317VLL8"/>
    <dbReference type="GeneID" id="37114667"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF37">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016285597" description="Mannan endo-1,6-alpha-mannosidase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY75264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="449" mass="48355" checksum="091FCD47E9D5CDBB" modified="2018-10-10" version="1">MVRLTYVAAATLAGSATAIDLDITSQESIQNAAATVAYNTMSYYTGNQTGQIPGYLNSSWWEGGALFNTMIQYWYFTGDASNNPAVSQGLYFQRGNDNYMPSNWSSYMGNDDQMSWALAAMTAAELDFPQGTDMPSWASLAERVFDMQAARWDSNTCGGGLRWQIWPYEAGYTYKNAISNGGLFQLAARLARYTNNQTYSDWAERVWDWSVNSLIDEEWTVADTTTTDKNCSTFSKVQWTYNYATYVSGAAYMYNYTNGETAKWKTGLDGLLNTTFSTFFPEKYGGNIMSEVTCEPTHVCNDAESTYKGLLAGDLAFVSVVAPYTASEILPRLQGSAVGAAKQCSGGDSGTVCGQRWYQSTWDGWSGIEESMSATSIITSTLVAYKEQIPATQATATNQTVSANGTVTGNGTTASTASGSSSGVVKNGASALAYGPFGVIAAVVAAVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLU7</accession>
    <name>A0A317VLU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_499872</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463970.1">
        <property type="nucleotide sequence ID" value="XM_025609396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLU7"/>
    <dbReference type="STRING" id="1450535.A0A317VLU7"/>
    <dbReference type="GeneID" id="37111539"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF111">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016195120" description="Transmembrane 9 superfamily member" evidence="7">
        <location>
            <begin position="23"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="608"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY75343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="647" mass="71858" checksum="6871AE11CCB5B783" modified="2018-10-10" version="1">MWFTKRSSPIALLLAAPSLSAAFYLPGVAPTSYDEGQSVPLYVNHLTPGLAQQDEQLHSVFSYDYYHPAFRFCPPKEGPKDVRESLGSILFGDRIQTSPFELHMGKNETCKSICGQVSFDARSAKFVNRRIEQGYNINWLVDGLPGAQINMEAVTQTKFYSPGFALGSINDDGQPILNNHFEILIEYHRVGYGNQDKYRVVGVLVQPESRRNSVILEDGTPQCDSDGVGVTLSEDGETMVAWTYSVYWRESDTAWATRWDKYLHVYDPKIHWFSLINSAVFVVFLVAMVSMILVRALKKDIARYNRLDMINLDDFDGTSAAVEDGIQEDSGWKLVHGDVFRSPKSPLLLSVLVGNGAQLFMMTGVTVVFALLGLLSPANRGFLATAILLIYTLFGFIGGYVSARVYKSLGGESWKRNIIMTPVLVPALIFGVFFLLNLFVWAKGSSGAVPFGTMLALVLIWFVISVPLSVAGSWLGFKQSAIEGPTKTNQIPRQVPPMTGTLRTVPSLLLTGILPFGAIFVELYFIMTSLWTNKIYYMFGFLFLCYGLMVITSAATTVLLVYFLLCAENYRWHWRAFAGAGMTGSYVFLNAILFWITRVSFGGLTGAVLYVGYSALIGFVVFILTGSIGFFASWAFVHRIYGSIKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VR98</accession>
    <name>A0A317VR98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_205652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464298.1">
        <property type="nucleotide sequence ID" value="XM_025606114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VR98"/>
    <dbReference type="STRING" id="1450535.A0A317VR98"/>
    <dbReference type="GeneID" id="37108257"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000657">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000743">
        <property type="entry name" value="U3 small nucleolar RNA associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="62"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="105"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="322"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="9">
        <location>
            <begin position="355"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="418"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY76485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="447" mass="50878" checksum="A9178230B045EC7E" modified="2018-10-10" version="1">MKIKALSRPTSSQQAPGTSVVRQPRNLDPAQHPFERAREYTRALNATKLERLFAAPFLGQMGDGHVDGVYTMAKDPGSLQRFASGSGDGVVKVWDLTTQGEVWNTQAHDNIVKGVCWTPDRKLLSCASDKTIKLFDPYNSEPEAPPLATYLGQGAFTSLTHHRDLPYFAAASSQISIYDLSRPSSTPSQTLHWPTNVDTITSIAFNQTETSILGSTGIDRSIIMYDLRTSSPLHKTTLRLASNAISWNPMEAFNFAVANEDHNVYLFDMRKMDRALNVLKDHVAAVMDVDFSPTGEELVTASYDRTIRLWNRSTGHSRDIYHTQRMQRVFSAKFTPDNKYVLSGSDDGNIRLWRSNASERSGIKSARHRAKLEYDQALIKRYSHMPEIKRIRRQRHVPKPIMKAREIKREELGAIKRREENVRRHTKKENLPKRQSEREKMILAREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUK6</accession>
    <name>A0A317VUK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative AMP-binding enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_498136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464586.1">
        <property type="nucleotide sequence ID" value="XM_025609341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUK6"/>
    <dbReference type="STRING" id="1450535.A0A317VUK6"/>
    <dbReference type="GeneID" id="37111484"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="66"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="517"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="615" mass="66783" checksum="C8DC4774AE5FD223" modified="2018-10-10" version="1">MPGRTLMPLLSRSSAASSRPPLQTLIAWRACNHRFRSLVAPVIRRSLSSLPNLPLFRALQNHDQSNLAVVHSASARSFTYGNLVADVLQAKERLIGSAGGKQDGLSGERVAFLAENSYDYVVTLLSILASDAIALPLSPAFPIGELKYIMDNSQAKVLVATEKYAGKAQDLLKAGLDRVPVLDVKDKIKVGAHNSGSVSLEDLNAKSRGGMMLYTSGTTNRPKGVLIPQSALTAQAASLLEAWNYTPDDRLLHLLPLHHIHGTVNAIVTPILAGSSIEFMFPFNTDAVWKRLAAPFLPATPTTSKITFLTAVPTIYNRLLSSFPGLSPDIQEAARKGISPENMRLNISGSAALPTPTKKAWQDLSNGNVLLERYGMTEVGMAISCGLDFADRVDGSVGWPLPFVEARLVDTDTNEVINAGEERDNNGREREGEIQLRGPTIFQEYWANEKATKESIVSGEDGKGEWFRTGDVATRRIVDNAGKGTSGEWAKGPMYFIQGRRSVDIIKSGGEKVSALEVERELLSLPQIAEAAAVGLPSDQWGQKVAAIVVLRPEVAKKTGRNGKTWGALDMRRALKDRLASYKMPQEMKVLDGPIPRNAMGKVNKKMLVKEVFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW72</accession>
    <name>A0A317VW72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_604240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464335.1">
        <property type="nucleotide sequence ID" value="XM_025616455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW72"/>
    <dbReference type="GeneID" id="37118598"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="457"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY77148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="589" mass="63924" checksum="3DB3DFF2DFEEE341" modified="2018-10-10" version="1">MTFNITIGPSPHDSDHSSLSDEEDSSGVQVSPISDSESHGYHDHYEEWAHLTYPDEIKPSDSASRPRTTRRTRTRSIITGPTSTADRRHSARRHLVQERDTFSRRSRRHPSPDSPESADSAEEYGSPYGHASQERRYWSSVPQVPGYARSSSPGPSYVYPSGTSIPHAPFMHPAGLPPSDQLVRLSHNGQVGQQTTYTHPVYGYTSQLQQPHGPPMPPFFVHEHHPGHHPHQVSTASHSRGDGHNPPQHAMSHHISPHGPSPYGAPPLGPHDLVPYGPGSYYPFREPYPIVPGMISPYFNPYPRVPSPSQVESSESPAPAPAPAPAPVDTAKDEAIARLEKLIMEERTEREAREAREAARQAAIEQEAAEQVSREERAAHEKKITEEAAARARAEAEQKAAEEAAKAKQEAEEAATAAAAEAAAAATEAANAAAAEAVAAATAAAAAAAAAPPPPEKKKPIKFKDAVGRKFSFPFELCCTWQGMEELIRQAFLHIEVIGLHVAEGHYDLVGPNGDIILPQVWETVIEPDWTITMHMWPIPEKPKTPEPIPPPDPPAPQEPPPPEVAAAPVDEAIVILEEPKKKAEPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYC6</accession>
    <name>A0A317VYC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_164720</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464936.1">
        <property type="nucleotide sequence ID" value="XM_025605894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYC6"/>
    <dbReference type="STRING" id="1450535.A0A317VYC6"/>
    <dbReference type="GeneID" id="37108037"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000013">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="9">
        <location>
            <begin position="202"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="484"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY79364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="967" mass="106405" checksum="C134E91888450BB4" modified="2018-10-10" version="1">MAAMEELEIHSKSYFVRWVSVKSAHTISWSIQPHKKSINFGIFKHPGHSAVLGSNTNLSATDAPNSESTENLPSTAGTAAALRPNASVIDKLTGIGLKQIQWLGKCEAERIFRGTYDVPTNEGGNYALVFDNTFSKQISKTVTLALLTYPTALPPQSVPVPHASSQPVQRSDTADSGKPLAARRRGNSMAQPPPLVSDPDSGRTYTGLLQKRRRKRHQGWARRFFSLDYTSSTLSYYHDRNSSALRGSIPLSLAAVACNEKSREISIDSGTEVWHLRAYNDQEFAAWKRALERAASASPSKTPADDTLQPEPLLRVPSQRVVTNSVEEREWEHVQSLVSKVSGSRDAVRRLAKDTDPKYIGGNASEKPRGRSPSPQRTPTDLNGDESGDAKRPFWKRKNSTATQPGVKRSTTMASMSSQLAVPGAFDTASLAGDRKPSSVSSHPDQMEEIHEHLMAVLRDLDQVVSEFSTLISESKQRRHPPGTTVQSRRSFESDVSQEFFDADDGNLLTIKGDSDDEVADNASDNTAWEPKTKEPVADDAPSDSEDEADEALAGGAHDQFSPLFPARPKTLTPLPLSTVARRTNITAPTVMPPSLIGFLRKNVGKDLSQISMPVSSNEPLSLLQRAAEVMEYSTLLDRAASSSDPLERLMYVTAFALSPISSNRVRERAIRKPFNPMLGETYELVREDLGFRFLAEKVSHRPVQLAYQADSKDWSLTQSPMPTQKFWGKSAEIITEGKMRLTLHTTGEHFSWAQATSFLRNIIAGEKYVEPVGEMSVTNETTGHRSISTFKAGGMFSGRSEDVNTKAVDSSGRDLPLGLIGTWTSSLDLTKNGSPTCTIWSTGPLVPNAPKHYGLTSFAATLNEVTPIEDGKLPATDSRLRPDQRALEDGDVDQAEAVKVQLEEGQRARRRDMEASGESWTPRWFTQVDEDQATGETVWRLKSGKEGYWDERTRGSWPGVVPVFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYK0</accession>
    <name>A0A317VYK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_175989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464720.1">
        <property type="nucleotide sequence ID" value="XM_025605940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYK0"/>
    <dbReference type="STRING" id="1450535.A0A317VYK0"/>
    <dbReference type="GeneID" id="37108083"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="147"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY78411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="386" mass="42627" checksum="C99361A506CC3B30" modified="2018-10-10" version="1">MAPHNVRWGIMATGGIADSFVRDLLRDPAIRDVFDVSHTVVAVASSSSSARAEKFISDTGIPAPCAAYGSYHDLVADANVDVVYVATPHSHHFQNVMLTLEAGKNVLCEKAFTVNAAQAKILCDTAKQKNLFLMEAIWTRYFPLSIQIRDLIKQGAIGEVLRVISDNSFGDPVEETWGTEHRMVNKDLAGGCLLDLGIYSLTWVFQTLYHTLPREQRKPPSAVSAHMTLYHLTGADEATTILLSFPTTTPSNLPHLGKSQAVAMTHLRVATDPDETNSARPAIRIQGTKGEIQVDGPAFQPERYRIIPKKGEGESKEVECPFPGDGRGMFWEADEVARCLRDGKLESETMPWEESIVIMEVMDEVRRQGGLTYPEKIESTAYPLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W058</accession>
    <name>A0A317W058_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_182243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464867.1">
        <property type="nucleotide sequence ID" value="XM_025605980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W058"/>
    <dbReference type="STRING" id="1450535.A0A317W058"/>
    <dbReference type="GeneID" id="37108123"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="303"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY78558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="592" mass="65239" checksum="D9333E10838E0B61" modified="2018-10-10" version="1">MGQSHSKGNSSPGDSLQSYPSFSRSDTKESLRSIRGSIRSKIRSSDSPRASTSALSQTESQTDRSDAGSIKSAASRRSSTNLSTQSPIADDAASKSDAPDPPPSPSLSSSLKRGHQDVSAMQQSGEVDLVSDAPPTGVAPVGPSTQAVGESILIKRENQLNPILDFIMNAPIEPSGSPGMGMGALKSIDLDDMISRLLDAGYSTKVTKTVCLKNAEITAICTAARELFLSQPALLELSAPVKIVGDVHGQYTDLIRLFEMCGFPPASNYLFLGDYVDRGKQSLETILLLMCYKLKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFIDTFNCLPIAAIVAGKIFCVHGGLSPSLSHMDDIRGIARPTDVPDYGLLNDLLWSDPADMEEDWEPNERGVSYCFGKKVIMDFLQRHDFDLVCRAHMVVEDGYEFYQDRVLVTVFSAPNYCGEFDNWGAIMSVSGELLCSFELLKPLDSTALKNHIKKGRNKRNSMLSSPVSCPLLSHLPRQVTAQLLCNDAETSVLWLTMFLFCTNGCSPHLSRPRATRCLGDYMPSNRRPSYVTTRRCGLSPPWWLASIYSIVRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W0F7</accession>
    <name>A0A317W0F7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_603168</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465047.1">
        <property type="nucleotide sequence ID" value="XM_025616437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W0F7"/>
    <dbReference type="STRING" id="1450535.A0A317W0F7"/>
    <dbReference type="GeneID" id="37118580"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14654">
        <property type="entry name" value="ZIP_Gal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000009">
        <property type="entry name" value="C6 transcription factor (Gal4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005600">
        <property type="entry name" value="Gal4_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="11">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY79475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="668" mass="74938" checksum="3F7975440F76C0E9" modified="2018-10-10" version="1">MASTRDSHSYACDECRLRKSKCSKEKPVCAQCKQLNKECNYSPKVTRSPLTRQHLTYVEDRLQAFETALARLFPGGDLDATVRSLLHDQEGPKPGSSKSSSRHSTPAKAEPDRAEAAPEALPQQADGFDWAENKITVGDLTDGMAALSIKPEGTGYFGASSSVVPLRALLKHGFDLNIPARSSKSSYGVERVPLKAQLLSTAPSGLIEQAFMDAFFLNYHTSYPFIHEGTFRAQFHEQVPRPHGQAWQILLNTILALGAWSIGDDNSDLDITFYQEARSHLQQVSVFETGNLTLIQALLLLSNYAQKRNKPNTGWNFLGLAVRMAMSLGLHKEFPGWKISLLQREVRRRLWWGVYIFDSGAAKTFGRPILLPEDSVMDAKHVLNIHDEALTSITTTLPLEVNEPTLYSGLIAQARFHLLTNSVYQRLISGPSLTPEETLGLQKPMEEWYNGLPDYFKQPPTPVSDAFALVRNRLMWRDWNLRILLYRPILLRWASRRWTPNSAPEPEDPLEADCRKLCLRNARLTLSSIADFVNNHVCTRIGAWYMLYFLFQAGVIPIILLMTDPTSTEAPSWLQEIEATKKLLVHPSLSNNRLATRCLEVVNRLCSPAYTSAATDRAAGPPILMPFADQLFNDPAFGSLFPDVDQELNLSGMDFSDWVNFAPQNDFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W262</accession>
    <name>A0A317W262_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_163690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464909.1">
        <property type="nucleotide sequence ID" value="XM_025605887.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W262"/>
    <dbReference type="GeneID" id="37108030"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01254">
        <property type="entry name" value="PH_PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="467"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="935"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="12">
        <location>
            <begin position="1241"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="188"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="353"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="560"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1409"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1462"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1620"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1657"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="253"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1476"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1626"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1657"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1668"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1720"/>
            <end position="1737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY79337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1826" mass="207126" checksum="1D8B480AB94CEEAA" modified="2018-10-10" version="1">MTDYTVNPLEVRGSENTPNRYYSRQPEPMSLDSPELSSPLPSPSLTREDADRADVANEGEDQVDGTQITRGVRGTHHEAKGKSRAEHASGSWEEEMGNISRPGKPASLSLRQPNDATVNQQHPGSRKSQTPILGSSASPRRPSVQFTQDTPDVDTANQSQSRPPSVKGDEVDLGLKGKQSLLTKLKSFAASPSFTSHTRSASGATLSDFRTTNNDMATPGSERGEFRFPNTLEEEGSDIDADAEESAGEQRARQQKKKKKQPRRRQQDDSMPPTQPNTPKVTSRPSFHLPSSFAPFENYRPNFFPRRGSTGDFTHQHREGVSEDEGRDRLNKDTTWRRRSAWLANARGLTYSGRQLETQANPEERRPSNLRRLTGLAGPSDNAEGIAPPWRRHRTDRGSSLSAQRWRQIKAGLKLIGQRRKVDNTVDHAKSAELLAELTSGVPAALILASMFQRDEHGSKRIPILLEQLKVRVTDSKIDSHSGDRHLVFRIELEYGSGMTRMKWVIYRTLRDFANIHLKYKLHFGTQKYIQLRNTEGGQNLPRFPRSAFPYLRGVRGLESDMEDEEDDGGYETAAEATSGNERAGKKPQQAHRRSSGGLSRRQSNATNPEAEGAAGASGPTEAGQASKKESYPERQRKKLESYLQKLIRFLIFKPDSNRLCKFLELSALGVRLAAEGSYHGKEGFLVIQSSKGLDFRRALTPGMVKKRHSPKWFLVRHSYVVCVDSPEEMNIYDVFLVDPFFKLQTQKVSLRNQKAKDFAKSATESARHPQHHTLRLENSERRLRLLARNERQLHQFEDSIRFMVNNTPWARPNRFDSYAPVRHKCFAQWLVDARDHMWVVSRAINQAKDVIYIHDWWLSPELYMRRPAAISQKWRLDRLLQRKAREGVKIFVIMYRNINSAIPIDSEYSKFSLLDLHPNVFVQRSPNQFRQNTFFWAHHEKLCIIDHTLAFVGGIDLCFGRWDTPQHLLTDDKPTGFETPDGPKDADHCQLWPGKDYSNPRVQDFYDLDKPYEEMYDRNVVPRMPWHDISMHVVGQPARDLTRHFVQRWNYILRQRKPTRPTPFLLPPPDFEPADLEALGLDGTCEVQILRSSSMWSTGTPDITEHSIMNAYVKLIEESDHFVYIENQFFVSTCEIDGRKIENSIGDALVERITRAAKNKEAWRAVIVIPLMPGFQNTVDSEGGTSVRLIMMCQYRSICRGETSIFGRLRALGIEPEDYIQFFSLRTWGKIGPQKQLVTEQLYIHAKCMVVDDRAAIIGSANINERSMLGSRDSEVAAVVRDTDMIWSSMNGRPYLVGRFPHTLRMRLMREHLGIDVDELMEHSMATEEELRRIEIAEEGSKPPESQLDSESLMLEKKDERDMIERRHRLQDEFLSRSEDMHSFNHDVDWEQGNNPNLKSNRKLTADPRVTSNAEHKKDVDGFGPDNLTTAQGAGLGDARDSEFMGAKTEVLISPIASEGKGTIQQPKHPFQRNAHRENAAGDKEAKPTLKNILDEQGNEAMPVVEGLPTVRHPALASEQEIESNNSGNLVASRDKHDPVKSAHLFAPDLKHIFIDKDCMRDPVIDCFYLDTWQAVADKNTKVYRSVFRCMPDSEVKSWKEYKEYAAYADHFAEMQNQHSAKAFQPPGQRQTGPPGTGASVAGAAAGLKHNLSVHVQSTDGQQKEQSPVERSEPRVAESGQTTDAQHPELANPEGLLPLNEKSTTKVADGTAAGNLPNGRHEESGSSGEDLERQRSDPPLVDYSEALNRNATGQSRRRRRRATTLGSKREFHATDEVMDKQRAEELLNHVQGHLILWPYDWLEKEEQGGNWLYTLDQISPLEIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W478</accession>
    <name>A0A317W478_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_496987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465280.1">
        <property type="nucleotide sequence ID" value="XM_025609307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W478"/>
    <dbReference type="STRING" id="1450535.A0A317W478"/>
    <dbReference type="GeneID" id="37111450"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016297591" description="PEBP-like protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="23098" checksum="F768DE64B6C37169" modified="2018-10-10" version="1">MHATTLISTALVAATALAQTSSDIWPQTTTNLGVSFGNMIVTPGVWINPNDTVYPSVFPGHSTSTYPGTYMLMMVDYDVADSAFAALDQYSSLVRGRLVNTTTRLHWWGGNYTLQDGKFVNSSNALASYHPAQPSTSRVHDFTIFLFDQSDDYTPPQDVLDGLLEEHDPRHNFTLAPIVEAVGGPLAATYFWSSTPGVPDSSSATYSYAWTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4Q4</accession>
    <name>A0A317W4Q4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_558374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465126.1">
        <property type="nucleotide sequence ID" value="XM_025614005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4Q4"/>
    <dbReference type="STRING" id="1450535.A0A317W4Q4"/>
    <dbReference type="GeneID" id="37116148"/>
    <dbReference type="OrthoDB" id="2153661at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12769" checksum="1E2C98F4801E7133" modified="2018-10-10" version="1">MFPLFVVMYGIFNALGEMGPGVSTFLCAAESLPTPLRGHFLGLAAANSFSSTEKGQQAVFLIGSAFTIVGVLIAWFLIPDMSRELETEDAKFKAYLEEIGYDISSYGEALCVERKGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4W9</accession>
    <name>A0A317W4W9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinesin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_537208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465196.1">
        <property type="nucleotide sequence ID" value="XM_025612217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4W9"/>
    <dbReference type="STRING" id="1450535.A0A317W4W9"/>
    <dbReference type="GeneID" id="37114360"/>
    <dbReference type="OrthoDB" id="123929at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005871">
        <property type="term" value="C:kinesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000091">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000120">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115:SF1008">
        <property type="entry name" value="KINESIN-LIKE PROTEIN SUBITO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24115">
        <property type="entry name" value="KINESIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="11"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="700"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="116"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY80337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="733" mass="81233" checksum="BB458C1916886B06" modified="2018-10-10" version="1">MSSTKSSPASLFQVYLRLRPPMAQHVQDQAERCLTVESPGTNVIVEDGLEAPASFSTHITLQPPVDSRKRAVERFGFTKVFEESASQLDVFHGTELESMVRGVLLEGRDGLIATLGVTGSGKSHTILGSKTQRGITQMSLDVIFKSLASTIRPLDNSISPLLLSTVAASDVSESQMFTAPTFLEAVYGDPTERGRSSRAQTPMSTGRANTPMTDPMPAIIFPRRNMPQRPGNAPRSPDVSHLTMELNPHSEYVVLVSMYEVYNDRIFDLLSPAVAPGQGSTMSRQGGNAQKDRRKALFFKSTEGSPDRKIVAGLRKIACSTYEEALSVLEVGLTERKVTGTGANSVSSRSHGFFCLEVKRRMRNKRTGEEMWIGNTLTVADLAGSERARTAKTAGSTLAEAGKINESLMYLGQCLQMQSDIQDGNKAAMVPFRQCKLTELLFSNSFPSSNQTSGFNRRPQKAIMIVTADPMGDYNANSQILRYSALAREVAVPRAPSIAESILSSTLGSRHGSTSGRNTPSPSTNEELEKAAVEIARLTAETESLAVKLAEEEILRADVEMRLKASEERCILIEQEVREECWNEMDERMEEERKRWQSAWDQQAGFNDEHLDKKIEIVSRGFQIHEDPQPSSNERIEDLEFENDQLRSKIATLERELTCRSPTKKPRSKNTLETSRNSNILGRESDIEGALKRMDQLKLADSMFSPVPQTSSPGKRQRKMATRKWDLAPEEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5D2</accession>
    <name>A0A317W5D2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NCS1 nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_601453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465621.1">
        <property type="nucleotide sequence ID" value="XM_025616387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5D2"/>
    <dbReference type="GeneID" id="37118530"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF1">
        <property type="entry name" value="URIDINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY81553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60582" checksum="F74581B1E9E653A7" modified="2018-10-10" version="1">MAWESIHERLLVKSVNQDGALRPVGALDNDSIRPTPSRQRTWTRLTYIFFWFSATANVSNLYASSTGVAMGLTMWEAIACSFAGQFLAGCLMALNGRAGAMYRIPFPVLCRSSFGPWGAFWPTFNRAAMSIVWNGVNITQGAQCLYVFLHAIFPSIARIPDRMGSKSSLNTAQMICFLVYWLINCAFLVVPVPKMKKLIYIKVVVYYGGAFAMLGWVVSLAGGNPPGLRAPSEVQGEAKSWLICKFLFLGLASCGTFISNAADLQRYTRKPSDAILGQIISFPLSGLMVAVIGNIIAACSTSIFGELIWNPLTFLDKLMEGERYTPGNRAACAFISLAFVYSTVFSAIFENSIPAGNDIAALLPRYITVKRGFFICAILSYAICPWYLLATASVFITFLSSYQIFLSAIAGILICDYYLIRRGWLNIPELYTSRSDGMYHFFYGFNLRGFGAYIVAIAPNFYGFLHQMGVKAPLGIQRFYFVAYPVGVLIAFGVYYLGCFIWPPTGMEKTREWKEPKDYWDEFDPDRGDAETVEVVPVVVEGHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5R0</accession>
    <name>A0A317W5R0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase, CysE/LacA/LpxA/NodL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_601700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465751.1">
        <property type="nucleotide sequence ID" value="XM_025616392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5R0"/>
    <dbReference type="STRING" id="1450535.A0A317W5R0"/>
    <dbReference type="GeneID" id="37118535"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY81683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="188" mass="20626" checksum="94E12CD19042F0D9" modified="2018-10-10" version="1" fragment="single">MTSSPEWDKMLRGKWYHAGDAILQENRTRCRKACEAFNAARDASRREKVKLWREIIGDTRPLPTEHPDAKEDEALFEETDPFVDGPISIDHGLNFKVGKNSFINFNALVLDTCLITVGENVLFGPNVGLYGALHPMDPAERRGLKGPEAGKEIHIEDDVWIGAGATILAGVRVGRGSTVGACSVVTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5T5</accession>
    <name>A0A317W5T5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_471739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465092.1">
        <property type="nucleotide sequence ID" value="XM_025608395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5T5"/>
    <dbReference type="STRING" id="1450535.A0A317W5T5"/>
    <dbReference type="GeneID" id="37110538"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="3">
        <location>
            <begin position="127"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY79520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="328" mass="35895" checksum="7C750CE6F31E2D16" modified="2018-10-10" version="1">MTIVTVKHVAIAELVVYIPISLVTLLVVLRHGFHKQLGWIYLFIFSGIRIAGAVMEIISEKHPDNTSDVEWATILQSVGLSPLLLSSLGLLKRVFDEICQHGPSSPGSRHNMLLQELSSVSGIATKLIGIYSQKATAISGRSKIVQLLHVPSLIALILSIMGGTDQASSNPSDHAGGKTETRVGIIIFLAVYVALCILWLTTVKDLQRMASSQKRIIGVVLIALPLIACRLLYSLISDFSHDRRFSLVSGDVTIRLCMAIIEEFLVVLMYTILGVFTPRSDANRVPSSPQQWPYGTADPESHTAPIVPRGAGRQKYEPVGPEYSHLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W7Y9</accession>
    <name>A0A317W7Y9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_154502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465129.1">
        <property type="nucleotide sequence ID" value="XM_025605832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W7Y9"/>
    <dbReference type="STRING" id="1450535.A0A317W7Y9"/>
    <dbReference type="GeneID" id="37107975"/>
    <dbReference type="OrthoDB" id="4492304at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.20">
        <property type="entry name" value="Apolipoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016245575" description="Cell wall protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="23684" checksum="EAC3E3C631B98E66" modified="2018-10-10" version="1">MKFTGIAASLALASTVSAAAIPVVETTVQSTLTQLTGVLGKVDNVADGLVGCASNDLTDLKDELSTIEGKLTQLLPSSKRDLTSTVGGVTTPVVGIAGGAASTVGGTASGAVNAVGNVVGGAVNTVKGVASPVVETAGDAVNTVENAASPVVNTVEGVASPVVGVAGGAVGTVKGAVGGVVNGGVSANAGAGANVSLKRDVDDLSSLSETLVAKIQSGDLTVTGLDNILGLLTEDGGLANLQSVLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8L9</accession>
    <name>A0A317W8L9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sugar transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_625792</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465715.1">
        <property type="nucleotide sequence ID" value="XM_025617309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8L9"/>
    <dbReference type="STRING" id="1450535.A0A317W8L9"/>
    <dbReference type="GeneID" id="37119452"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016448233" evidence="10">
        <location>
            <begin position="24"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="15"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY81647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="502" mass="55578" checksum="A5E127BB02E2A523" modified="2018-10-10" version="1">MASRRSQWSRMLVFTTCLLAVSAFNYGFSDQAFASCQAMDSFERQFGVYHPTTGKYKVRPMFTSLYNSLKAATQIIGVFIGGYISNTYGRKICIFSMNLYALASAAVVVSSTTDGQILAGRALHYIYLGMQMAVIPTTLAELAPRNVRGAMGVLYWLSIKIGGLVVTGIARGTSSISTNTAWRIPFGLILVIPFICIFLVWIMPESPRWLLLRDRQEDAFQALKRYRSQNTPESEIQEDFDELAQKVAAQMQKKKFKDLFTPKNRERTFVVVAANFFQQASGQAFASQYGTLFVKQLKSVNPFSVTLGTNAVDIGALIISTGLSDQVGRRMLFHTSGILETAALMTMGGLGTADSKNVAAKEGIVAMLLLYSFGWSLAWAPLVYVLGAELPSAPLREMTLQIAYTMKLVTEFAVTFSYPYLETANDPGHVDIGGKLGFIYGSLSAVSVIFGYFFIPETRRMELEDIDKKYDSSTDSEMVEKVEYQLDSQKESHRGASRPVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8S6</accession>
    <name>A0A317W8S6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF862-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_148256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465775.1">
        <property type="nucleotide sequence ID" value="XM_025605780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8S6"/>
    <dbReference type="GeneID" id="37107923"/>
    <dbReference type="OrthoDB" id="4420847at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016264132" description="DUF862-domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32367" checksum="C9F66F606188B8FC" modified="2018-10-10" version="1">MWSKSISAKNGFALVSLLLTTRISAAAVPSGPVSVSVTPSYVADVAENTHISTIGADGETALVPVVGGPECYFCPQEEENNQTIGGWALLGISGAGTYLPSAVSEFTEPIPVITVSTNGDPTYVPSKTTRQPATEVKRAETPTVSDAKYRILEAALGKRPEVGKAYALKQKNVLTTVLGVDVPSHYLLVAGTVKQTYESLMGSYELTFDGYCYDIRRTGSKDQYITFNNRCGTAAATSWYQKEDEAKFELLGEIKASLTPTDINNIGKEVSKEMEKKNYGTFTNNCRHFVMKLYAKIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9A2</accession>
    <name>A0A317W9A2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="7 11">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_469141</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="10 11">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="7 11"/>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465971.1">
        <property type="nucleotide sequence ID" value="XM_025608284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9A2"/>
    <dbReference type="STRING" id="1450535.A0A317W9A2"/>
    <dbReference type="GeneID" id="37110427"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1480:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="225"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY83186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="446" mass="48395" checksum="3765E6BEED7675FF" modified="2018-10-10" version="1">MAAPAQKFKVADISLAAFGRREIELAEIEMPGLMAIRRRYAADQPLNGARIAGCLHMTIQTAVLIETLVALGAEVTWTSCNIFSTQDHAAAAIAAAGVPVFAWKGETEEEYNWCLEQQLNSFKDGQKLNLILDDGGDLTSLVHQKYPEQLKGCYGLSEETTTGVHHLYRMLKEGKLLVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCSDALRSMGARVLVTEIDPINALQAAVQGYEVTTMEEAAPQGQIFVTTTGCRDILVGKHFEVMRNDAIVCNIGHFDIEIDVAWLKANAKSVQNIKPQVDRYTMANGRNIILLAEGRLVNLGCATGHSSFVMSCSFSNQVLAQIALFKAEDVAFGKKYVEFGTSGKKPVGVYVLPKVLDEQVALLHLEHVNGKLSKLTPVQAEYLGLEVTGPFKADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9P6</accession>
    <name>A0A317W9P6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_576737</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465412.1">
        <property type="nucleotide sequence ID" value="XM_025615152.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W9P6"/>
    <dbReference type="GeneID" id="37117295"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="574"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="618"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="714"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="801"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="277"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="576"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="892"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="523"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY80810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1413" mass="157943" checksum="B5B55E5927176547" modified="2018-10-10" version="1">MGELGMRCGFPTDDHFGPRVLPCRREFDLTLLFEQTILGLGPDLLFLVLCPLRWYQIHARLRRVNQRSSGRWKTVSNGLYKRQAIRVITMIRARFVGMIYAETLHQVSKSSHESSSVTLMSTDADRITTGWQLWPLPYVRTPKFLAWASKIVNNITNPYKRVSFTSAILKGMRQIKMFGIEPTVETKINRLREVELESSKPYRSLIVWVNVLGAVSTALAPAVTIAVYAGMQLNLGFETPKTNVVFTSLSLISLLTNPVVLISVSLTRPTSAIGCFDRIQDFLSEEGKRPQVADRPLITGIVSGIEMNTMRLDTQELVSMNGACFSLPTGSSNSSTPSTSKSSIPRFRIFIAPVRKAYCQQCPWIFNGTLQTNIVGESPIDVKWLKEVVYACNLDVDVARLSHGIDTVVGTSGSQLSGGQKQRVALARAIYAKPDLLLLDDVISALDSVTCKRVVERIFGRSGLIRRLGIATVLVTAAAECFQEAENVIVLSSNGRIVDQGSLEDLSVKNEYIRELMCRTGSKQDENEVEDADAPSEETETQADNHGPRVAQEPTPNTRGTGDLSLYAYYINSFGWWAFCFTLTFATIYVLCVALSQLMLTWWADSTPGHNYVYLGSYMAVSTVAIPAIGVFIGFFFVWTVPRSAINLHKVLLGAVMRAPWPSIARMDTGSLINRFSQDMSLLDMQLPVAFGITLQNFLTCLAQAALIATGAGYMSIVISFCIGAVWTIQAFYLRTSRQIRLLDLEAKAPLYAHFLETTEGLIIVRAFQWQQRFSDRNARLLNTFQKPFYTMYCIQQWLQVVLDLLVAALATVLTALAVFVTRKTSSRGVGMALVNLLSFNSTLTLLITNWTQLETSLGAIARVKQFVNDPQVRPVVRNEMAVEDWPSMGRLEFRGVTASYSEVSPPIIKNISFTLEPGHKLSICGRTGSGKSTLLSCLFSLVTLTSGEIYIDNIDIFTLPKDRLHSAIVPIPQHPLIIPGSVRENLSLGTITTTDEAMISALSTVHLWTQILEHGGLDADIQSIHMSNRQQQLLCISRALLLPGSLVVLDEPTSGFDEQTEKMVQDVLSEGLRGRTVISVAHRIRTIMDSDVVVVMDEGRFPAPAPTPPHPCLTSPHPHDHLVIDTDPVADKTAQIIEKIQWYVNIIHTIIRALRPSNLPETAQKIAFWLELFLYGIGIYKPLRGTGYDYGDIVEMFGFTSRVGEIWNDEIGYRPEGLNERIAETAGRWPHEGVTRRKVSIVLHEMYETVKETHGADNLRFVETRRMKRTLQHGFRIRHVHGTIDFSLWFGDLDNAETNLLVKIGTNHLSSEVLLYMGLLQRDQQRLKTRKRGIIYGIMTDGSAYHFYRLDPDKTNDVGDGQVVDSGYLNRWDGLEWDDLDTECEVASLQSMALTSNSNRLIPYEPHMPTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WB85</accession>
    <name>A0A317WB85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3 6">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_494895</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3 6"/>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466224.1">
        <property type="nucleotide sequence ID" value="XM_025609245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WB85"/>
    <dbReference type="STRING" id="1450535.A0A317WB85"/>
    <dbReference type="GeneID" id="37111388"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000003">
        <property type="entry name" value="3-methyl-2-oxobutanoate hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001452">
        <property type="entry name" value="PRK00311.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY83756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="349" mass="37520" checksum="2490A5FB8C073A8E" modified="2018-10-10" version="1">MASRSSTQWLMPLARSSVRCRTASASVFSVLAGRPAIATRSGCEPQKRYSSHSPLGVDPANPRKKVTMQTLRSLYKKGEPITMLTAHDFPSGHVAELAGMDVVLVGDSLAMVALGMEDTSEILMEEMLLHCRSVARAVKSAFTVGDLPMGSYEVSPEQAVQSAIRIVKEGRVQAVKLEGGAEMAPTIKRITQAGIPVVGHIGLTPQRQNALGGFRVQGKTTASALKVLKDALAVQEAGASLIVLEAVPAEIAALITKKLRIPTIGIGAGNGCSGQVLVQIDMTGNFPPGRFLPKFVKKYADVWGEAVKGIQQYRDEVKSRAYPSQEYTYPIAKEELAEFEKAVEHVHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBF8</accession>
    <name>A0A317WBF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_566955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466304.1">
        <property type="nucleotide sequence ID" value="XM_025614593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBF8"/>
    <dbReference type="STRING" id="1450535.A0A317WBF8"/>
    <dbReference type="GeneID" id="37116736"/>
    <dbReference type="OrthoDB" id="5371334at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="36405" checksum="F74FE327F2BBC3A5" modified="2018-10-10" version="1">MSARPAPLGISRRLPGLAGSPGYGTDQDQRDIPIPTTNVTIPISPLQQRHRGRCPLHPLIIGLHGGGYDHQYFNATPTYSASRLSTALQVPFISIDRSSYGKTNSTPPIPETSDFSQETGHWLHKYILPKLWSEIGLPNQCTCIVLCHSFGVMGGIVAAALHAEEKTPLYALGGLIASGMWNTQAPSAMERSTLSYVPIDADHVMFGVDTKDTVMFKPGTAAPEILDQCEQLNAACPVAELRGFAETCLPSWKEKWAARVTVPVLFALVEDDPFFVATEEELGICVKAFRNSKRVDGSLVRGAPHCLELSLCLRGWYARCFGFALECAAGFEGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WC22</accession>
    <name>A0A317WC22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylate hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_520457</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465748.1">
        <property type="nucleotide sequence ID" value="XM_025610110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WC22"/>
    <dbReference type="STRING" id="1450535.A0A317WC22"/>
    <dbReference type="GeneID" id="37112253"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF5">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="142"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY81680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="429" mass="47242" checksum="6232711D4F872083" modified="2018-10-10" version="1">MSSVRPTKEFTVAIVGGGIGGLTLAVGLLRRGVPVRIYESAPAFKEIGLGLTIGPAAHRAMPLIDPQIRELYDSLITTHADSPGYERFRQTWFEVIWATGDKAGEVLLDLKALPSGQTSVRRADFLDALVSLIPPDISNFGKRMVSLSETPNGMDLFFEDGTSATADVVIGCDGIRSTVKEFVVPEEYRQSLPRYSGMYGYRAVLDMETMVKAVGDHRARVSSMYIGHGAYGITYPIARAKKVNAAFYTFRDEWDSDTWVRPASMADMMKDLEPVMGGCVNSLLQHMPDTSQWAIFEQTPISTFIRSRVALTGDAAHACTPHQGAGAGQAIEDSHVLAELLGDARVIRVEDAVAAFEAYDAIRRPRSRKVIDSSKQNAYLLSLCLDGVGADDEKFKSALQERLQWLWDIDVEDQVERARTDMLKRLGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDI6</accession>
    <name>A0A317WDI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_625656</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466077.1">
        <property type="nucleotide sequence ID" value="XM_025617301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDI6"/>
    <dbReference type="STRING" id="1450535.A0A317WDI6"/>
    <dbReference type="GeneID" id="37119444"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY83292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="490" mass="52992" checksum="51075FAEC0411B1D" modified="2018-10-10" version="1">MAIASPQPEPPSETTSLLAEHDEHPVQRKSATRRAHRVLLYACLIAVTLDFGNYLSVAPQLQAFESIICQRLHPELFAYTPGGGLPLVASPSCKSADVQGDLALLKGWMNTFDQLPGIILALPYGLMADRIGRKPVLAMSLLGIVMEEIAIRLICWYHTTIPPQAIWFAPLFQIIGGGSQITNSVAWTIIADVFPVEKRSVAYFILSGAILLSEIVAIPLSAWIMSSSVWIPWMLGLACEIGGALIVLLLPETKPKSAENPVSDVESETADRPEGSSAFAWSSIVRFARSQITELKDFVCEHPSSLVVFLAFFMSSYGIVAVPFMLQYVSRRFSWSLAEASLLISVKGVLNCLALVFILPMVSKLLGRYFTPVKRDHRIVLGSACILVAGFGFMSLASHPALFAVGVALIALGWGYYAALRSVSSALVGQSHIGLLNTTMALAQSVGLMVSGPLLAGLFRAGLAWEGIWMGLPWMFGVVLYVAAGLAYHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE38</accession>
    <name>A0A317WE38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_536337</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="16">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="5 18"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466661.1">
        <property type="nucleotide sequence ID" value="XM_025611994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE38"/>
    <dbReference type="STRING" id="1450535.A0A317WE38"/>
    <dbReference type="GeneID" id="37114137"/>
    <dbReference type="OrthoDB" id="418412at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000001">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000009">
        <property type="entry name" value="Galactose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943:SF1">
        <property type="entry name" value="GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 18" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="11 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 18 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase N-terminal" evidence="19">
        <location>
            <begin position="7"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose-1-phosphate uridyl transferase C-terminal" evidence="20">
        <location>
            <begin position="216"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="14">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="28"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="347"/>
            <end position="348"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="352"/>
            <end position="353"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY84736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="385" mass="43422" checksum="AE43F826639EE13F" modified="2018-10-10" version="1">MVESVLDDISHRRFNPLRGSYILVSPHRTKRPWQGQQESPSKTTLPTYDPACYLCPGNKRAQGDSNPAYEKTFVFVNDYSAVKEEQAPYTAEGGEDLESFFLKAEPVTGKCYVLTFSAAHNLTLADLSPAEIVPVIDAWTEIYTAHLSPKSPLAAVAPATTLPPNSPTASLTKPKEQYRYMQIFENKGAAMGCSNPHPHGQVWTTSSLPEEPAMELEQLKKYRQENGGKHMLEAYAALESRKQERVVFENDAFLVVCPWWAVWPFETMVVSKTHKRALVNLNSTEKEQLAEAIAEVTRRYDNLFETHFPYSMGIHQAPLEGTEEEIESSYLHLHFYPPLLRSATVRKFLVGYEMMGEPQRDITPEQAAARLRGCGGELYRKKMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH03</accession>
    <name>A0A317WH03_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Anion-transporting ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_468220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466467.1">
        <property type="nucleotide sequence ID" value="XM_025608235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH03"/>
    <dbReference type="STRING" id="1450535.A0A317WH03"/>
    <dbReference type="GeneID" id="37110378"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="11">
        <location>
            <begin position="26"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY84542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="326" mass="35876" checksum="0C393A0917C1E258" modified="2018-10-10" version="1">MSSAVVHSDDLMEPTLQSVVNQKTLRWIFVGGKGGVGKTTTSCSLAIQLAKVRRSVLLISTDPAHNLSDAFGQKFGKEARLVDGYSNLSAMEIDPNGSIQDLLASGEGQGDDPMSGMGVGGMMQDLAFSIPGVDEAMSFAEVLKQVKSLSYEVIVFDTAPTGHTLRFLQFPTVLEKALAKLSQLSSQFGPMLNSILGSRGGLPGGQNIDELLQKMESLRETISEVNSQFKDADLTTFVCVCIAEFLSLYETERMIQELTSYNIDTHAIVVNQLLFPKQSSACEQCNARRKMQKKYLEQIEELYEDFNVVRMPLLVEEVRGKEKLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHE6</accession>
    <name>A0A317WHE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_536002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466883.1">
        <property type="nucleotide sequence ID" value="XM_025611915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHE6"/>
    <dbReference type="STRING" id="1450535.A0A317WHE6"/>
    <dbReference type="GeneID" id="37114058"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="43"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY85866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="386" mass="43273" checksum="5D17CDB575E75AB3" modified="2018-10-10" version="1">MLGFPKSDRTVRVRLVDTTTLMTVRSEVLVQPVQAGHEILNLTDVAFLIEHEGTNQKVMFDLGTRKDYWNLPDAVRLVFDQGMPSARIDKDVSEVLTESGIPLSDIGSIVWSHYHWDHIGNVALFPPSTSLYVGPGFKAEPRLLPGFPDDPYSPVPADAFVGRDLVEPNFADGLKIGGFRAHDFFGDGSFYLLDTPGHCVGHLCGLARTTADTFLFLGGDICHFPGVIRPNVNLPFPTHIPKESLDEDSFFPAPCPCRLFSDHHPRVKSDQSQTPFYEVSSYEATAFTDPQLAQQTVTKLLEFESSPDVLICIAHDTELLRHLPTLNDSPSSDLNAWKEKGWKEKIRWGWVNELPRAGHPGRKPLVEGYWREGKVWEEAVETLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHK6</accession>
    <name>A0A317WHK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_112453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466148.1">
        <property type="nucleotide sequence ID" value="XM_025605515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHK6"/>
    <dbReference type="GeneID" id="37107658"/>
    <dbReference type="OrthoDB" id="4509557at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="363" mass="41176" checksum="CE5B108787AE9063" modified="2018-10-10" version="1">MQNHNHNRILTPISIPDTTNTNDKNMTLRRWLSLKPKPKAKSTPNLSQSITTTAKPRGLFRSKTPAPTSIPIHTDPNPLTNPTSTNTPPASTVTTNPPQTGPPNPPPPPTRTRTPLSILNLNLHFNLTFTPKGANPNPNPNPNPDADADTDATSTTTASTTRTTSHLIPQTTSEQELTSSYAAYCEAFTSGLTDENYLHASVEDEQSLQQLQQQQHTVQSAEGRGKEKGPVYDVEMQTDTRMDMRLEGGEEEDDDRVLPSRDDQREVLHWLRNPDDQDQDQDDSVEHRRISPPARILTPARYEQSRRAVRLQQRRQDRWKREQQQQQRHAWWTAIRTGWARVRRRAGEAANPENNRHNRQGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHQ2</accession>
    <name>A0A317WHQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein Psi</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_467741</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466816.1">
        <property type="nucleotide sequence ID" value="XM_025608219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHQ2"/>
    <dbReference type="STRING" id="1450535.A0A317WHQ2"/>
    <dbReference type="GeneID" id="37110362"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000136">
        <property type="entry name" value="DnaJ domain-containing protein Psi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY85799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="373" mass="39969" checksum="217B4A8F15CEB884" modified="2018-10-10" version="1">MVAETRLYDALSIKPDATQDEIKKAYRKAALKFHPDKNKDNPAASEKFKDVSQAYEVLSDPEKRKVYDQFGLEYLLRGGPPPSSAGADGSNPFEGGMPGGFSFGGMPGGGGGGGGGTRTFHFSTGPGGSGSGFRFSNADDIFRNFAKGGMGGGMGGMEEDDIFSMLGGGLGGGRGFRNSRGPSGFKQSSQRAPTPEPTVMEKELPLTLEELMRGTTKKVSVKSKTFDASGKRTVQDVTLEANIKPGLRTGSKIKYRGVGDQEEGGRQDVHLIVTEKEHPNFKRQGDNLVTAVELSLKEALTGWERIVRTIDGKSIRVSKPGPTQPGHEERFPGLGMTISKKPSERGDLVVRVNIRFPASLSASQKEVLRDVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHR7</accession>
    <name>A0A317WHR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_586584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466533.1">
        <property type="nucleotide sequence ID" value="XM_025615767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHR7"/>
    <dbReference type="STRING" id="1450535.A0A317WHR7"/>
    <dbReference type="GeneID" id="37117910"/>
    <dbReference type="OrthoDB" id="5300765at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="76231" checksum="63FBE17671770991" modified="2018-10-10" version="1">MSVEFSYYQPSTPPALHLQEYVGTGHSRNASDSSVYSNNSSPWSAITSATSPIVDSPPQHHHGPTLLPKIRPQDVVIEPPPTSGSHRQRRVLSNTRNPPGFLPFSSNRRPSQHNAVEASECVSLVSPVVASPTYTARHGSTLSSPVSVTPLQKRKATSGHSRSVSASNVDDSRPNRGSYPAYRQVLRYSSQPQSSPTTPATPATPNIIVYPPYAQHSPIEPCYPKVWPQMQVPLMLPGSPYGYVRASSAQCSPVGLVHHTEGPHPQSTTLLSYLTAPTQAINLVRNVNVIPMRGLHDFFWWDIRNLRSWTSFSLSTFNSISGLPKLLKTAISSHLTPSTILPSSYLSPDCEPALVSVIRDIYAPRINAALAVSQGPDHLTLYDVPIPHGSPNKHYGGPHFLANYASDTERTSSGLPRGRLVGIVKTFDRWNTGMRNEAPHRRVEYLNGLAHLQRCMREHSCRYGFILTEIELVCVRAGCDEGDDVPYFGFLELSSPIPTKIAVSQHGHGPEPYSSAYGYPHSPTPSTDSSLASQSPVLDSYPMSGSEELDVPMTASLALYFLLMLSKSVPLPAQPSAHLNVGGPGALTRQRFLPEGKDKWIPEPQMGERRDAKRVRVFIVFLFAYVYKHSAVSVGSPDQCLQPTDLPESSITSIITYNDRLKVDQFMKPSPKVLTPLSTPISSVSSMAIPNFPFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHS6</accession>
    <name>A0A317WHS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptide hydrolase</fullName>
            <ecNumber evidence="11">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_493913</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase M28 family. M28E subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466846.1">
        <property type="nucleotide sequence ID" value="XM_025609214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHS6"/>
    <dbReference type="STRING" id="1450535.A0A317WHS6"/>
    <dbReference type="GeneID" id="37111357"/>
    <dbReference type="OrthoDB" id="2214at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF56">
        <property type="entry name" value="AMINOPEPTIDASE YDR415C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016189502" description="Peptide hydrolase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="12">
        <location>
            <begin position="212"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY85829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="442" mass="49017" checksum="6831CC6F2C98632A" modified="2018-10-10" version="1">MLASTLLLLWGTAGAALASPHPLAESQVVFAPSPEAPNAPNAYGQHHVDEAILSALNTHSDPVAALVSLRPEAAAFLAEPRLLHVRGEEKAEWMTEGDKIRLRRRGQKFIDITDHHEFYAEQATTASAGNPNLPDLAHKRLVKPLFAHVETQRMYNVLQHMTSYYNRYYGDFHGEKSSEWLHDHIAEIIAKSPFRTHISLEYFTHPFRQSSIIARFEPKVRNFSLPLTIIGAHQDSANYLFPLLPAPGADDDCSGTVSILEAFRILAENGYTPKYGPVEFHWYAAEEGGLLGSQAIARYKKEQGAKIGAMMEFDMTAFIARNATETIGFVATQADAALTNWTVNLSREYISIPAEVYELGPNAGSDYMSYTQLNYPSAFASEGNPLAGGDFPGEFDPYVHGVNDTMYIDDETGVFSLDHMARFSELAIAFAVEQAGWDNSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WIX4</accession>
    <name>A0A317WIX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_517479</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467005.1">
        <property type="nucleotide sequence ID" value="XM_025609996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WIX4"/>
    <dbReference type="STRING" id="1450535.A0A317WIX4"/>
    <dbReference type="GeneID" id="37112139"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="11">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY86414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="296" mass="33270" checksum="30C17BEE15C4BEC1" modified="2018-10-10" version="1">MNRFRFGDSDESASDLDDDTSGLPFPEPLSRASFLAPDFDPATYLSSLTNRHQSLEDLRQELRDLDQLLSRELLDLVNENYQDFLSLGSALHGGEEKVEQVRVGLLTFQRDVQSIRDNVEARQQEMEELLKEKKRLKTQANIGQALLDYADRVEELEKKLMIGDTPRQPHDGSPDGSDSDSDLLESASEDSDEEELPNGASTTSLVSLKTLEHHIQKYVYLTRLSSRIGDEHPFLKSQQPRIAKIRSAVLLDLKTALEQASHAGDKRDTKTLAVLRLYKLMGEDTTAVSALKNMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJC7</accession>
    <name>A0A317WJC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_557014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467147.1">
        <property type="nucleotide sequence ID" value="XM_025613911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJC7"/>
    <dbReference type="GeneID" id="37116054"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY86556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="519" mass="59281" checksum="EFB18D6C3AD4F5CE" modified="2018-10-10" version="1">MLSCRLSSRSSPPREDFFKNTSRRWIMNENDRGKERYVKFDPNELQRVAGRAIGEDHCPFIIKLAEGGFNKVFLLRASSGKEVIARIPTPIAGPSHYTTASEVATMDFLRGIIGIPIPKVLAYSTSATNPVGAEYILMERIEGVSLASRWLSLTTEEVKSVMKQIVEMEQRTFTYSFPGYGSLYHQKDIKGEEQIPIPVEDFCIGPVAARQFWHGDRNKTKIDRGPWLSPKYCFTSAARRETTCILNHAKPQPRKTFLLPTLYDIEPSEHISLLSKFLRLAPFLISTNPDHNSPILRHPDLSLDNILLEPGSTIITSIIDWQDTVIFPLFMQAGYPAFCEHDLSQPQSLQPPTLPDNFNYMNQANSYYTATTGIYNDIHMNALRIPHLGMRRYLYQQTGYPWDADIINLRAALIGITTPHIWDAISSVPCPVSFTDQKRETAKEDSEEWIESEKLLSAFRDHLGVDLEGGTVPKNFEWASHRNVELRLEMLQQAEHHERDICWQNWPFKDDADFSYSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKH6</accession>
    <name>A0A317WKH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_536288</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466615.1">
        <property type="nucleotide sequence ID" value="XM_025611983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKH6"/>
    <dbReference type="STRING" id="1450535.A0A317WKH6"/>
    <dbReference type="GeneID" id="37114126"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="79"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY84690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="174" mass="18704" checksum="0127989E79407B3C" modified="2018-10-10" version="1">MPVLPSTITAGTVRPESELSPFEKLVLSYSTGPESSNEGGEVWDYFPEACNLRLESATPGPPARVSYLLTVIPKQCNYMGSLHGGCAATMVDILSSTLLLGLSKPGHYSLGGVSRNLKLTYLRPVPSGTEIRVMCEMVHMGKRMALLRAEIQRINGSICVVGEHEKANTDPAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLY0</accession>
    <name>A0A317WLY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_75984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467557.1">
        <property type="nucleotide sequence ID" value="XM_025617652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLY0"/>
    <dbReference type="STRING" id="1450535.A0A317WLY0"/>
    <dbReference type="GeneID" id="37119795"/>
    <dbReference type="OrthoDB" id="5404323at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="591" mass="65365" checksum="4636F586708AA76D" modified="2018-10-10" version="1">MLFNLGLTADAAAAHENEYLGSPSEAQLPGPTRHSSPAISFASLPSWGLGNIYSRHKTPEPDMTQRTMPRKVTIDTLSSSDDERSTIAPVLAPSRIARSQSQSVRKQSSRPKTSYQLAHPAGHARHRRLKLRPKLLLQLQRVSQTPRPLPILDVLPSTVFLPPLARKFPTIFRGKKGLGPNDLIVVTSDLYERAHGDVGDRHLSSDDESGEQREVVATICQLFRDDALSKGKAEICLNHGPVWEATPLANGSYEFVANTDHGVRVLRWVLRGGGKNRRVSAPPGFASQEDGKRFTFSVINPNTRRHPVVGTMTRNYLEVYDEFSMPTASGIASSPTSAMSVMSDLSEMDDSLDRKVMTTDNELRMLIIVTSIWVAFREGWSHNFTYDDSALALNSKTMCPSRHSSPTAVRVDSDKLFEQENGQDDGPAPNGSRPRLSTSTYVPSQTTTSDRSAFGSLSRRSNSTGAAFIERTNRRASGSNGRLNRHSTLSSPREQRQDEAAEAAPARQDSKSRRLWSHRKSDIQDPKKATTPDQKPDRSQAFESHQSRPVETSRDLGAKPSAGDSAPTKGKRRHRISSLFDFIIRKTGHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMC0</accession>
    <name>A0A317WMC0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_466162</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467413.1">
        <property type="nucleotide sequence ID" value="XM_025608149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMC0"/>
    <dbReference type="STRING" id="1450535.A0A317WMC0"/>
    <dbReference type="GeneID" id="37110292"/>
    <dbReference type="OrthoDB" id="4132249at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF19">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="580"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="591"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY87205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="610" mass="67660" checksum="DF662F263EDEBDBA" modified="2018-10-10" version="1">MDSHPSPTKQKAPKQACDNCRRRKIKCSRELPCDKCRRLLLSCSYSDVLRRKGPKFRTLYPLAPIHPLVSRQQNQYYQNPPQNPLNKQWPADGVGYPLSSPTSPPFTVADAQYLPHDVPEAFAQLPPPELVSSPDSTNSLSDSGMAIVRPYARRLSPPVLLAHVNVYLKYLFPIMPVVRKEELQQDCHQPDRLSPQRYAFLVALCAATHIQLKLDGTASVPDPSHLQPGIDGHSWMSGEDLLAEAVRARKDCDPVDGMNIESLLTSFFLFASYGNLDRQDHAWFYLCQATSMVFTLALHRESSYVELSVEEAEERRRVFWLLFVTERGYALQQAKPVMLRNSIRKPQVLCSEDPILAYGFINLISIFEKLTVNLYDWVSAGGMDGSPEMPPTSAIQSSLSNAISVEGVSEIQKVDILITQQWLQTIMWKLSMTRVTQPGSRDEAVLPFHLPVLVGKAVMNVIGAASQGAVDAHGIGMEQKLFDLGSSVADVSRSLNAKAAHRLTEVAIDPRELLWGILSTLSRIRGSQSYLFPTLLERCKGALDFTSPTSMSNFLPLPPSSASWGGESGLAVISLPENPDLHEQETEVGEPLPQLLPPSQVQFPDGSLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNH2</accession>
    <name>A0A317WNH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_61290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467802.1">
        <property type="nucleotide sequence ID" value="XM_025616691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNH2"/>
    <dbReference type="STRING" id="1450535.A0A317WNH2"/>
    <dbReference type="GeneID" id="37118834"/>
    <dbReference type="OrthoDB" id="4243861at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY88019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="171" mass="20169" checksum="CF62E169F44DEAE3" modified="2018-10-10" version="1">MDNTIQPVREHIIRQIRVVLSEFLPDVGSGTLRILGVTPNSLLDPEDYVESIRPFVSETEQYLQKYHPDNETRFIAAKIVRGKTSYFILDLNNTDYNYETAHECKTRIPVYVLRPSKRQPTIFRKRELDASIAKILRNMHNLHGQDPLPLFDNHYDENLQYPNPRRPQFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQU0</accession>
    <name>A0A317WQU0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_574876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468236.1">
        <property type="nucleotide sequence ID" value="XM_025615044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQU0"/>
    <dbReference type="STRING" id="1450535.A0A317WQU0"/>
    <dbReference type="GeneID" id="37117187"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="269" mass="29274" checksum="C793D2C1A34ADC1A" modified="2018-10-10" version="1">MSSQSPPTIVLVHGAWHTPTAYQPFISALKAQGFTVHAPLLPSSAQSLNPSQSQHQDKPASLPEDIACIRNLISTLANQGHRILPLFHSYGGVVGTDAITRDLTLPDRQSRGLPGGVIHLVYICAYMLLPGGSVVKTIQEGGVENPAETIVDVGDDRFMYPKDPIAQMYNMVERGVAESVVGGLVRFPFEACDMESVGEAWRFVPVTYVVTGSDRMVWREWQVGMVGRVREHGGDVRMVELDSCHSPFLSKRGELVGVVVGAARDERNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSA6</accession>
    <name>A0A317WSA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PD-(D/E)XK nuclease-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_565484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467973.1">
        <property type="nucleotide sequence ID" value="XM_025614498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSA6"/>
    <dbReference type="STRING" id="1450535.A0A317WSA6"/>
    <dbReference type="GeneID" id="37116641"/>
    <dbReference type="OrthoDB" id="4161186at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046797">
        <property type="entry name" value="PDDEXK_12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20516">
        <property type="entry name" value="PDDEXK_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PD-(D/E)XK nuclease-like" evidence="1">
        <location>
            <begin position="58"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="297" mass="32407" checksum="0051FF252AFFCFD0" modified="2018-10-10" version="1">MSSRRSSSPSRVKAQLATATPKVVFLNESLNPECDAARELLGVLTSDEDATSRSNGRGIQMISNASSRCATELRSEGSWMMDVARPLLDLAIDELPLESWSVQTELANAKYLPRFANGTFSPKFDLVVGLPTEPWKAEYEQAGIDIFDRDLSHVDHPHTGKRILGLGMKVKAYGGNLIEAQVELAAWMAGLVSWGFASRCEPSESAEDASALPPPIVGCTFYIVYGIAGPSNQLSEVRIWGPLSDLSGQATSEKHTTALADTLRRVMQYIQGSYAEQLFSLITPRQDLSHEDQEGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT41</accession>
    <name>A0A317WT41_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_39091</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468437.1">
        <property type="nucleotide sequence ID" value="XM_025607322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT41"/>
    <dbReference type="STRING" id="1450535.A0A317WT41"/>
    <dbReference type="GeneID" id="37109465"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY89526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="185" mass="20550" checksum="C908C295094926F7" modified="2018-10-10" version="1">MADILTQLQTCLDQLATQFYSTLSYLTTYHDNIPTIPPPDIPPSLSAPPLAKIPKNSSTPPVPATIAQHQTTTQTSPPPPTPNPQENPEGGETDPALPAPDSAELFAARQRELARDLVIKEQQIEYLVSVLPGIGSSEEEQERRIRELERELRGVEGEREQRRRELGELRRRLGSVLGVLERGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WXC7</accession>
    <name>A0A317WXC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">EBP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_534224</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468359.1">
        <property type="nucleotide sequence ID" value="XM_025611491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WXC7"/>
    <dbReference type="STRING" id="1450535.A0A317WXC7"/>
    <dbReference type="GeneID" id="37113634"/>
    <dbReference type="OrthoDB" id="5415655at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="97"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY89448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="302" mass="34202" checksum="18276E8D341D5FD1" modified="2018-10-10" version="1">MAFKDSFESLWAASSVHYDNALQFLKTLADQNSTAVTTENTTLVESQIGRSNLPELSTMPFSIDLQTVFSFLFVAVLLVAAYAFTNRCLPARDHERRFRLLFFWHLIDALVHFTMEGTFLFHCFFSYAAISPSQNREPVFLGDKDHVYGATYSTWPSAQLWQEYAKADSRWGGADANIISLELITVLFGGTAAAIICTWIYQVSTGRSSKGSVGEKRGKMWFTMIALATAELYGGIMTFMPEWLTGSQSLSGNWFHVVVYLAFFNLVWVFIPAWVLYEAWKECTTVFYRHGKDSSSRKMTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYA0</accession>
    <name>A0A317WYA0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP-LTD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_22326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468690.1">
        <property type="nucleotide sequence ID" value="XM_025606231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYA0"/>
    <dbReference type="STRING" id="1450535.A0A317WYA0"/>
    <dbReference type="GeneID" id="37108374"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY90312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="36420" checksum="A8FE793DB7DD9808" modified="2018-10-10" version="1">MGKPNLTPEPFNFVELVQQTYDDSRVIIAVCLVSWIVGRLDLGLTWLLFVLAVCRTYAVVSLTRVQRILRDECRRYHAYKILSRGETVEWANGVLQRFWHMYQDRICDHVVRYVNNGLARRTTTENGGALQKVVIQSLELIDLPLRFTRVFVHHKPSSPNLIVEGQFQVNLAPHPSHHHLIESSGHPLIDLTIVHDKNARDPHNRTHDLAVQVRQFSSTGSLRVELDLEGDHPALLQPQVDLQDHPKMDCTIKSISQHHFPLHFAHQVDWRRVVEMQLREGLGWAFHRPLPLPFTLGERWVFRAMTWWWHAVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYS5</accession>
    <name>A0A317WYS5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Opi1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_555370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469274.1">
        <property type="nucleotide sequence ID" value="XM_025613789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYS5"/>
    <dbReference type="STRING" id="1450535.A0A317WYS5"/>
    <dbReference type="GeneID" id="37115932"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="483" mass="52277" checksum="A595C965B2E45709" modified="2018-10-10" version="1">MKPRPNGRSDPDATAPTVPLPHTSAPSSSSASILPAHSSAPSTAYPPFQHVPPPMMDVDHGTVAEDRSRRATSVLSMDDLEAAQALEGLRTDDLAEPPDSKPQPEPLLSLLTSTHPLISSAINGSVSAYTNSKSYSPRFKSSAEFIERNIGSPVANTVGTVGRKTGVESGLRWALLRRASSSAQSSRSKRRKVSGEQHPTEVDVEKGPDDTMESPRMRSPSDLSPAEVPPPYDDEKSPNYDEVNRNSPSRQTPPTWQSRLMISTSGLGVAMSEESLRSLQYCLTWLRWANGRLDKAIDALKTALKEWDSSRQQSDDAATGSDASSTTLLSQRIQAVKEDVLSTLKRVVDIVSKYAGGALPENARNLVRRHLTSLPHRFQVASTSNPPPDSMAAASDATVGAHRILVLAQEGLDMMSQVSGVVNDTLVSAELWCERLGRKRSEGKNSAEVQPPREHDEPYPADVKLPIQEPSPRDVSMTGMEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYS9</accession>
    <name>A0A317WYS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_573950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469257.1">
        <property type="nucleotide sequence ID" value="XM_025614997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYS9"/>
    <dbReference type="STRING" id="1450535.A0A317WYS9"/>
    <dbReference type="GeneID" id="37117140"/>
    <dbReference type="OrthoDB" id="2163491at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035516">
        <property type="term" value="F:broad specificity oxidative DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051747">
        <property type="term" value="F:cytosine C-5 DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032852">
        <property type="entry name" value="ALKBH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31573:SF4">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="3">
        <location>
            <begin position="413"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="645"/>
        </location>
        <ligand>
            <name>2-oxoglutarate</name>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR632852-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="688" mass="77050" checksum="5A2663994951A0E1" modified="2018-10-10" version="1">MGPRKPAKATSRQAPPVISGRITRSKTSPRTGGVQRRTPSVEGRSRSRSQETSPATVEGQPPAWAMSRPELCDALPWFRAVQGGVYHSGNLCLGFLIDADFGIGSYADEEIIITRADSGGGCTKDAEGNLVLLKDQDDDSSAISSIANSMKLRVPVGLIIGDRNTLLDRKPPHRYNVMAYFRITHLWYEKIGRKTGAKVRFQKLDLSQKSWWATKDPPLLEERDFDLQPAQACCAACGRASPQVYEEGWMCLRPSCDRFWTNENASTPSQNLSFHPDFLRARLPPDLSIQPHYSLVPDLLSTFTESDGDVLSRRIAWKGIVCPQCARCISRTFWWGWKCADISFPPGVSHECTFEKMLGMRPVSLRSVIEELEMSPIKRALSFDPKFMVPEIDDRTLYPYRKLTYEIPGVGSITHLVSNRAINTRPNGPDDLFKQLQVADLGLRRYPLERSVVGGTLTAHFAVNYGMPYKYVVSVATKGFDEACDEILRALGRLTWATEQAVTNAGDCFLPPNELLVLGYFEDMKIRYHDDGESSLGPTVATLSLGAKSTMLIRMKYKYYHGYSKSKKVLSEDPVLEGCEDYARRQDLKSQLTDGSINQTTDDELRSGPLTKGRGGEASPCIKMELNHGDLVVMHGKDLQKYYEHSVIPEKRLRFALTARHVKPEQLDATELEKGQFSLLQDQVYDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZP0</accession>
    <name>A0A317WZP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter, amino acid transport and metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_395105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469223.1">
        <property type="nucleotide sequence ID" value="XM_025607351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZP0"/>
    <dbReference type="STRING" id="1450535.A0A317WZP0"/>
    <dbReference type="GeneID" id="37109494"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF332">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="200"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="592" mass="64633" checksum="383D90D821B2922D" modified="2018-10-10" version="1">MADLSTSPGRNPDSDPREASNNNTNEDNNHILSQHLHPQFTASLQDELVPPPGDAPAEQSSGEAPSEPQSSLKLQGGDIHRDLYRIDAKSKQARLDKRAATFSFLPRHADDAVEEGVASLEPGSFRRHFIQNKYGRLDQPGVTSSFLDFLDIYGNFAGEDLADTEEESAIVEEEDEREISERTALLRRQKSSRASRPGDASNVKTFFTLLKAFVGTGIIFLPKAFRNGGILFSSITLVTVALISTLCFHLLLECRRQHGGGYGDIGERIAGPRLRTLILASIVISQLGFVCACIIFTAENIHAFVEAVTKNQTTAVSIGGLIALQLLVLIPLSLIRNISKLGPIALLADVFILVGLAYIYCYDIASLVSRGMASTVELFNRQSFTLTIGSCIFTFEGIGLILPIQSSMKRPEHFDKLLYTVMAIITVLFTAVGALSYATFGDETKTEIISNLPRTDRFVNALQFFYSLAILVSTPIQLFPAVRILEGKLFGQGSGKRDPMIKWKKNVFRTGAVVCCGLIAAVGAGDLDKFVSLIGSFACVPLVYIYPAYLHWKGVAESPWVKRGDIAMMVLGVVFMVYTTSATVSVWLEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZZ9</accession>
    <name>A0A317WZZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Smr domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_533392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469677.1">
        <property type="nucleotide sequence ID" value="XM_025611320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZZ9"/>
    <dbReference type="STRING" id="1450535.A0A317WZZ9"/>
    <dbReference type="GeneID" id="37113463"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058864">
        <property type="entry name" value="UBA_10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26286">
        <property type="entry name" value="UBA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="145"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="469"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="60036" checksum="2FBE7004581C9B12" modified="2018-10-10" version="1">MGDKGDGPLQDLEKTYCPPLDPALLTAIAFDYDLTDSTQLQQLRDTLDALRLSAWEQEDLPFDPSGTSGLSPENSLEADGIFSERSGSQCDRSRTTDLTSLTSGFSSFGLSDRSSNSKSKSGSTTSDHVSYTIGPDGSLCLSGASDEDKIGYLTEMFPSADRFTIQHTIKKSNGDVDRAMDVLLNLVFFDEQAPDEDGLKVAVPKGVDGFEDGPGEARKQGRKRKPKNKSGRKQEVPSPLGSQPTLDGMPSLNKWDAAGKDVEFIHARTSPILKMEIVRSTYHANGASLSATIRTLASAHAPKDEKVINDDPVMVAQVAELTQEFAWVPPLTFAGLLKITRSSVSAASELAAAMLTEPVAPSISEMIKITTPPPPVDLEEDVHPRRGADPPATRDLYRARSAAGLHFAAGAEALSKASLAYRRGKSDRLMGGAAAYYSAVGRDHMERAKRNAAAAADALVDSQSTWNMLDLHGVSVQDAVRIASARVSEWWESLGDTKYRRGGSDPAWGGYRIVTGLGRHSHDGTSRLGPAVGKMLAREGWRVEIGAGVLTVVGVVRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0U3</accession>
    <name>A0A317X0U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ankyrin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_584570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468956.1">
        <property type="nucleotide sequence ID" value="XM_025615636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0U3"/>
    <dbReference type="STRING" id="1450535.A0A317X0U3"/>
    <dbReference type="GeneID" id="37117779"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY90578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="372" mass="42164" checksum="89BC761E77B6B72C" modified="2018-10-10" version="1">MDDLLLSIQWILFAKRPLKLGGFYYAILSANPDNLTDAWEPGSICPDDMSRFLLDSSKGLAEVTKSKDKTVQFIHESVRDFLLKENGLRELWPEHQHRFEALSHDQLKKCCNNFLQTDCRKHIPMDEDLPSASSEDARMLRQTLAEQFPFLEYAVRNLLHHADVAERDGIHQETFLRDLDFLGWVRCSNAIERYQIRRHTPSASLLYVLGEYDLPNLIRTVRKRKSCIDAAGERYRQPLFAAMVNGCEASVRALLQPDEAFRNIDGAYEVAQTLKYDSLLSFAADAEGGGLFLAACHHCHMNGVELGKLIFQAANDENKHLLQFMSMAYPLEIQTYVRDSICGDKAMFGSTVNVDVSGHILATGYVDPNAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1E6</accession>
    <name>A0A317X1E6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Importin 13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_533570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469150.1">
        <property type="nucleotide sequence ID" value="XM_025611358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1E6"/>
    <dbReference type="STRING" id="1450535.A0A317X1E6"/>
    <dbReference type="GeneID" id="37113501"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000560">
        <property type="entry name" value="Importin 13, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040520">
        <property type="entry name" value="Importin_rep_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18806">
        <property type="entry name" value="Importin_rep_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="41"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY91422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1031" mass="114568" checksum="0078C546716D81B8" modified="2018-10-10" version="1">MSVDIPGQAPDVQLLINEAKTLVSQLYDPGNTGNPAKIKAIQEHLQSLQKGPQAWLIANHLLSDGSTDLRFFGALTFTVKINQDWQSLSSEEAQELLGRLIEHYVFLVNGGERPLVIRKLASSLATIFLKPNAPWARALCNLAASLADGKHVSEEYCKSIDLRNAVLPAMSERQVTSLLYFSNILAEEIHRWSSEPRRSREEHHIYVNIKDAFVLVDFVLSHIMQQHASGIPVSDEILGTEVINSYQAWMNVRSAIQLRDSLSALDLASTTTYVIQSMKVPGLSKSATQVVVELIDWRDSIFTQHHLTAIMDYVISDLGTAHVASLLESDFEDENMTFLELLLAYATLKQRDLLTKQLDSRHAKMLSLLHTLFKAPGYAAVDDPASPLVIEWWTEVADDLQDTYMNSEDQTGLEPAKHNLAQAALDCFEKLKYPTPEELQGWGDDDRSEFGAFRRDVCDFLLAIYPMLGVGLVRVFQEQARLSLIQQEWRTFEAAIFCIAQLSEAVDENQHADECLNSIFFCDEFARLCEGNGVVIPDKPRQTLVDMLGKYQSYFERTHALLPRVLTFLFASLDVASCAPTASKSIAHLCKSCRNALTSELPAFIDQFEHFRFKPTATAHTMEKVLEGIAAIIQTLPTDEARSQILERILRFFHGQAEAARDEVVRGLVEQAQIRGQFVLRCVASIGKGLRTDSEVNLDSNDLGDGDPYPPTFWNTGSGAVSQNLIMQCMQLLITDFPVDVTVIEAACDILKAGYTEKSGPYVFPPMMTVDFVKSIPLGSVGTDMVMGTASAFLASHSLHPQRIRDETVALIVHVYDTFCWMHEKPAYYDPEVANSGIDFLTRLLAKYHPFLFALTSTPQEASQVTSTDGSGFQRPSVLEAVLNFTLISLQGPEPLPLRSASQFWVSVLNLPSDSGPIQNAIHQCLPALCRILMNQVAGRCARSDLEHLCEVLRKVIFRQQGAARPHLAAALAELGSTDNSSQHQGPSTSPEDRQRFLASLLAARGARAQTSQLARTFWVKCRGVSFDYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2S8</accession>
    <name>A0A317X2S8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4440 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469026.1">
        <property type="nucleotide sequence ID" value="XM_025611330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2S8"/>
    <dbReference type="GeneID" id="37113473"/>
    <dbReference type="OrthoDB" id="2865667at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="13"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="129" mass="14840" checksum="854E1BC5D4EBB461" modified="2018-10-10" version="1">MVGSIHERIREDLLAKERRLWTALTSADPGPEIKKMCNEEANLLFPKRDVLHLYSKPSISEALKPPFHHFEEYELQDVRVIVIDLMAGSVTYKIHARRGQDVFRGTGSTTWSQASDGEWRIVVHQETLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X356</accession>
    <name>A0A317X356_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_533566</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469146.1">
        <property type="nucleotide sequence ID" value="XM_025611357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X356"/>
    <dbReference type="STRING" id="1450535.A0A317X356"/>
    <dbReference type="GeneID" id="37113500"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="12">
        <location>
            <begin position="17"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY91418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="310" mass="32944" checksum="8ACBA20CBF8E25BC" modified="2018-10-10" version="1">MASQQNGGSNSAAANGFTVKAGLAQMLKGGVIMDVVNAEQARIAEDAGAAAVMALERVPADIRAQGGVARMSDPSMIKEIQEAVTIPVMAKARIGHFVECQILEAIGVDYIDESEVLTPADDVYHVTKHNFKVPFVCGCRNLGEALRRISEGAAMIRTKGEAGTGDVVEAVKHMRQVNSDIARARAILQSSPDYEPELRQLARQLEVPYELLRETAEKGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDAKKRAKAIVQAVTHFRDPKVLAEVSEGLGEAMVGINVSHLPEADKLAKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3P2</accession>
    <name>A0A317X3P2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_583209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469726.1">
        <property type="nucleotide sequence ID" value="XM_025615542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3P2"/>
    <dbReference type="STRING" id="1450535.A0A317X3P2"/>
    <dbReference type="GeneID" id="37117685"/>
    <dbReference type="OrthoDB" id="3533814at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="2">
        <location>
            <begin position="12"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY92965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="275" mass="32282" checksum="DF3B2470AA1BA8CE" modified="2018-10-10" version="1">MSTLNIRPVEGYDKLATFIASDPGLAFFRRFSKLNIKSLLYYQAEISNIEDDLDFIIQNDKDSQDDEKQGYPFSVRDLKDSMRRAKEEHPTQWLKIQEVRELLDKYNKALIQQRDLIRLSAPDKCDLAVLRDWLDRPECGNMFFETAAEMNVYHPRNEDDMLALFSRHEGVDTMTRWIFNRVIPWFHERWGEKYQKQSDDTGTWQYSDRKIKVFTYLFSVLIAAVLPASSMIVLYFIKDTAIRMVTIMVYNIVFSLALGLMVRARRVEIFAAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X481</accession>
    <name>A0A317X481_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_512752</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469486.1">
        <property type="nucleotide sequence ID" value="XM_025609820.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X481"/>
    <dbReference type="GeneID" id="37111963"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061499">
        <property type="term" value="C:outer plaque of mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031028">
        <property type="term" value="P:septation initiation signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052574">
        <property type="entry name" value="CDIRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47566:SF1">
        <property type="entry name" value="PROTEIN NUD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="452"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="522"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="734"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="825"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="937"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1058"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1188"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="629"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="834"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1065"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1081"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1105"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1133"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1199"/>
            <end position="1210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1841" mass="204216" checksum="A6E7151D786BD87B" modified="2018-10-10" version="1">MTDNPPWLDNLSDDWVPVPVPGTPTSPVPSRSVTHSRQSSLQLQDSPSRIPVPARRSVGPSPSPADNKKKVSRPCHFVKREPPKPKTPRLPKTPSKLRTPVPDKSKKSPRPDPPSRRKQQRAMDTRSPLRSVSNASGQSVQQSTVQVRPKKAKGTEGTPEWRRRLVQGDIPSGEQRDLFAPIGLESVFKPPTPGTEKTQDEAISRLKQSDSIWNFTTSPKLRDDVYSKDSPGDGRHGVGEGAGYSSPKSPRSPAKSPRLGQVEPKTGQGSLQGSHNGMLEVKKEPIEPALNQADGHDDSWNGTQLRTASGLEDLRNEDITPITFSQPNTMDGNAASEVIRSALKRVTNKLERLQLPPYERPDSRLSDSLLLNQPSELPAEPLPEDDLLDVTSHSLPKDLSMGTLDFRGRGAFANLRRDDYLNDGSFQKLHLSPPPFPSERLSPFLPANQRIRSSPPFYQKANPVTEPPTLPRPSSAHVGARRGADKVEVMPSSGSPLKLFGNHDTFTNNRLMRRMSQFEETFGGFSEDDEPVSPSEEARRKGESRSFMSAKQDTLGEPTRRHDRPRSRNTANPRINRFGDGELDHFDFSDTSPYEPKLLNNEALDPHQRSPSQRLSVERRYLRRRSYRNQSYSTEPNRSTKNSNSAGILDTASSTNVTGNRGLRGVEEFFQSESGSRPNSPAKDPNPKRRRTILKSHSLMQEDVGSGKIPSQAPDNLSLLQRSLMQHGVAYEGNDPLLRSQSTHRPNTPTPSQIRSLSRKRPSSSRNYSRAGYDDHGDQNSPPENAIPVVRVNGVNTETRKGSITTQDFLNEATKIMDIIRSKGRSAGGLSSVEESDAENQDESGSYEDESTREEFSRPPSREGVDIRKLREPTEPNPRILSHLKKFQEDDDQEFDVNASVMSLNLDQDESRSEDNHSIWDGDVLNEMDDGADANAQSVDSVQHMRKMSGPSDDGEEDDLPDLLTINTHVSAKSLSARSIPTGSSQSSHAKGVLSSDIVSHLIPEQVNGLTYDRYRNQWVKEKPRQSPGKLKGEDSEDDPFKDIPDLSVDELQEMMRMQSSLSPERVKGSSVRGEDNARQSSSSPHKSFSPSEEPPQTKEGDPSVNFSSLQSKATPFTSRFSNSETRATSWETDVRKTSKSTSEVEHEIQLHEGCLSKPSRRHQEHRQQARVVTISFSSPLVSQIAYDEDESPTKLRHKLGDPPPKHDPAIAEEGASVNESGGNSADALSLVRRGSGSVASTPDKNNGNNSLICLQNFGLDTTYSFHLSPLPDFTVHQIDQPLNLEMSYVAQRTHPTSLRQVHGTFALATEDLVKHITEAEPFEPHWEHVRRLVLRHKGLITLHKLSDFCPRLEDLDVTGNDIGQLSGVPPSLRTLNIQDNCLSNLTAWGHLSNLQYLDVSGNELESLDAFSSLIHLRELKANDNHISNIEGIFDLNGLLSLQLRNNGLTTVDFSRADLTRLHDLDLSHNQLNSITSFGSLPFLSALNLSYNRLTELEITTPLPSLQSLKLSNNVLRTLDIGAFPSLNLLYVDQNCLSSVSGLEQCRYLEVFSAREQMSDDVNRGFFDVDLGLVKDLRKVFLSCNKLSLQSLSPSTPLLSLQLLDIASCSLQGLPNDFASSFPNVVVLNLNFNSLTGVNELAGMKCLSRLTAAGNNLTRLRRLCQVLSHIGRTSKGKACSLQKVDIRSNPLTVRFYPPVIRNGKENVKKLKMKEELGYQHHVGLDIPSALAEFGRSGEMTHLDAVGEDDMPSPAKEIEVNDPYTLPLADPLADQRYLIHMDESTRLRRRIFELMLYAGTGGSIRLLDGLELRPSVHDGSDMDRAWAKLEKLGVLKKKAITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5D9</accession>
    <name>A0A317X5D9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_353017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470550.1">
        <property type="nucleotide sequence ID" value="XM_025607117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5D9"/>
    <dbReference type="GeneID" id="37109260"/>
    <dbReference type="OrthoDB" id="4508164at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016351495" evidence="2">
        <location>
            <begin position="22"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="162" mass="16681" checksum="B71ABFEBE6DB2ACB" modified="2018-10-10" version="1">MARFSLSFLVLCLFLAIMATAMPIKRADPDGATEMDSSLAEEVAAKSLQSAAKMMDEMAGQADESSQKDDNDTSTSDKTNSTPSPSTSNNSTPETENKQQPEADNQEPTPTTPTSTESSAASSPQPSSSSHIVNNNPFANLPIVGGLLSGGGEGSLGSGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6J7</accession>
    <name>A0A317X6J7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_325914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471007.1">
        <property type="nucleotide sequence ID" value="XM_025606936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6J7"/>
    <dbReference type="GeneID" id="37109079"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="234" mass="25569" checksum="78AC777CC38BD1B1" modified="2018-10-10" version="1">MITYVSDLPEPIAPCATLQRSPIQPASKKGCLSVRGYGNFCLPVADCVGLIGIDWGTDPTEINPTGLAAAFAFPLRQLARIGGMAIFKLPRSTRKLRSVQRAWSDMKVWLLPSWSAAVTPIHHLLPNNPVRARGLEVRYPCLMVPPVGSRSQAWCRVPDSYHGFPTGSSAPVHGTDRPVRSVYLFTIDVRYSGQTNAGRSNSVDGISRWDLAWRPATEYGVEAVERIGTLSPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6W4</accession>
    <name>A0A317X6W4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein TmpA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_532263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471074.1">
        <property type="nucleotide sequence ID" value="XM_025611087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6W4"/>
    <dbReference type="GeneID" id="37113230"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075306">
        <property type="term" value="P:regulation of conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN TMPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54215" checksum="AF6560C91E10BC4D" modified="2018-10-10" version="1">MSEPVQTVVTVPPPAKCASGPPSPSEATLTEKTFANSLSEKVEESRYPADNGSFDLESQVHKKRFAVIRYAFLNIYRRLFTIVFLANIAVFVAVLVTERTMLALVNATAGNLLACGLARQPLVVNTIFVSVCSIPRSAPMWMRRLAAKVYHYGGVHSGCGIAAFVWYVGFVGVMSQEYWSGQSALSLAPIILAYIILALLLAIIIVAHPKFRAKKHDYFELTHRFSGWLVVALFVILLMIFADQASAAYNESLGRFLLKLPAFWFLMVTVVAIIHPWVFLRKVKVQPEYLSSHAVRLHFNHTTTTFGKGIQLTRHPLQDWHGFATFPDPEGKSFSALVSKAGDWTSACIQDQPTHLWKRGVLTYGFAYAMRVFKRVVVVTTGSGIGPCLSFLGDANRPELRVIWQTRAPLKTYGQEIMNLVSEMDRNPVVIDTNQSGRVDMVPIIRQLVKDFDAEAVCVISNPLMTKKVVYELESHGIPAYGPIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6Z1</accession>
    <name>A0A317X6Z1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_272434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471145.1">
        <property type="nucleotide sequence ID" value="XM_025606571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6Z1"/>
    <dbReference type="STRING" id="1450535.A0A317X6Z1"/>
    <dbReference type="GeneID" id="37108714"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05137">
        <property type="entry name" value="RasGAP_CLA2_BUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039360">
        <property type="entry name" value="Ras_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194:SF60">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN RASKOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10194">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="509"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="4">
        <location>
            <begin position="731"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1118"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1135"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1198"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1244"/>
            <end position="1260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY94384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1260" mass="141113" checksum="C7CE5A591FC7EE22" modified="2018-10-10" version="1">MEPESSSGFKRNSIHQGIYSRPVERRPSKKSSSKDRHGMVYPDSFRDTGIRTVTPDSEAGNHSPSSEAEYLASSAAASPRPATRTRASDRESRRDYHSYHSAGDEEETHVEMKSQRARSRTTTLDDQRSEISQNTFFRARNRLGSINTANTQPKTPDEPTGSIGYPSIQSPTYFSHSLGRPRLSKHPGGSNLATSVSANQASSPLSSTDASKILQLMKTTCGRMHGILSFRTASTTAWSSGYCAINVATGSLIYQAKGEPALAKTLIPDLRGCQVRSLVDPELRTNYLSVSTFTSGLGVELRPHVSETFDSWLAALLCWQPIRPKGVQNKMTKPQSVAIGDRRLADRRRNSESTVQKEAAIIKVGKMLLWDRPSASGVRPSSGRRVSTYRQQRALSASWLRVSCTLQENGAFKLYTESDITLVTCVQLSQLSRCAVQQLHSSVLEDEFCIAIYPQYAVHSASGITRPVYLALESRVLFEVWFVLLRAFTIPELYGPETCTEDDPKSASGSADAAAPSMADMFRIERVLSVRVTEAKLLRNKAAEKAPRSRKQSRSHSNSTPTSAVGDYYTEVLLDGEIRAKTAVKYRTANPFWREDFIFSDLPPVLSQVSILVKTINPTQKDWTLIAHGSYALGHEHNNPNRLLDDVELSSHDATFGRVDLKLDDLQPGVETEKWWPILDDKDQPVGEMLMRARMEETVVLMSHEYTPMSEILHSFTNGLTINMAQVMSSELNQLSDALLNIYQVSGTTVEWISALVEDEIDGLHKESTANRLRYTTRIHSNDSRESGQEREVLVRDMGRTATVEANLLFRGNSLLTKALDYHMRRLGKEYLEETIGERLRDIDETDPECEVDPSRVHRSDDLDRNWRNLINLSTAVWKAIASSSSRCPAELRLIFRHIRACAEDRYGDFLRSVTYSSVSGFLFLRFFCPAILNPKLFGLLKDHPRPRAQRTLTLIAKALQGLANMTTFGSKEPWMEPMNKFLVSNRADFKQFVDSICAIPADRPAPIVTPSYATPIQILGRLPPTSREGFPSLPFLIDHARSFANLISIWLEIAPERLSELEDIDPAVSKFHEMALRLYQRTKECLSRAEQAERPNGSLEVKWEELVDSMERSVTFYDESSKPTSPATEAAVAGSTSLTGSHRNSIGYFASRPSLPRRSTDCAPEADEDTPPSSSSATWDQSRVPFSIPRWADPRDSTGSSKNSSTYSLDQEPSKSRRSSITRETSSKYRFFDFVPPSRRKAKDREQAQQSREEQRSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X703</accession>
    <name>A0A317X703_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_581790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471157.1">
        <property type="nucleotide sequence ID" value="XM_025615433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X703"/>
    <dbReference type="GeneID" id="37117576"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="429" mass="48151" checksum="4C75009BB5E4F60E" modified="2018-10-10" version="1">MEPTNFTFLNTTGASSLSKPATKRMRAHITKTNFAKRRQRIADATATKRSLDVSSGRPGWVSVSEASSASAFRRLQELSFLEGNYTPENPRDEAWLSLIASEPALIEALLAVAVRQWSPGSTWQLQADNHSYTAVKLVKQLITSTRPKTDGVLGAVVSMAIGAALTQDQVVWNIHINGLVDIVKSRQFQALPVVPSWFIDFLVQLVLLGPYTTHANDMNGRDSINSIFGFPRVYHQSIVEALGDDQGQRISKLANICNRVIQLRELMEFRHQHQFDAYFIAREIEEPLARLHYELRALRVESDAQVDAAARAIELVLYLLWPSSSGAHLTLLAAELKDAICRFPIKCCYYMNLTSFQLMVGAIAAEEGSLTRAWFVDRLARAVRVMHFHGWNEPLGIMQRKLTTDVGLNGRFRALWRELHHTAVNAEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7A6</accession>
    <name>A0A317X7A6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_318342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470832.1">
        <property type="nucleotide sequence ID" value="XM_025606890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7A6"/>
    <dbReference type="STRING" id="1450535.A0A317X7A6"/>
    <dbReference type="GeneID" id="37109033"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="151"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="249" mass="27195" checksum="08A7865894A5394F" modified="2018-10-10" version="1">MSATADSKVDPASTAPNDSNLSSQPPVINSEELSGPTFRENAQLESQEPSSSDAKPTDGDDNITSTPAPKQIPVDAAPSASASPEHYDEAKATAAGSELPSQGSDDTAKDEEDSGPSLVITLLLITGSRHPFKIDGKYLRKRSVNVENHDPFAMSVYTLKELIWREWRQDWEPRPSSPSSIRLISFGKLLDDKAPLSDSKFSRDAPNVVHMTVKPQEIVDEEDAKTSKSQYPRERESSERSPGCRCIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7C2</accession>
    <name>A0A317X7C2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_274949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471200.1">
        <property type="nucleotide sequence ID" value="XM_025606585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7C2"/>
    <dbReference type="GeneID" id="37108728"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="87" mass="9707" checksum="8F91490C7188A480" modified="2018-10-10" version="1">MILEWHSRTTTKLSLFIPSGHLHLQSSCTGFPAPKLLSVVVFCLASSVFFMLIALWSTSIERVVNLAIDIFEFQSARYVDGSLTCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7P9</accession>
    <name>A0A317X7P9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_457304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471320.1">
        <property type="nucleotide sequence ID" value="XM_025607739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7P9"/>
    <dbReference type="GeneID" id="37109882"/>
    <dbReference type="OrthoDB" id="3990906at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="8"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="652" mass="72851" checksum="E674DC39E8BF0430" modified="2018-10-10" version="1" fragment="single">SKQSKKVSCRRCHAQKVKCSGQRPCSRCQLAGCGDACTYVARDRKVRVDESYLEQLIKDSEELRRNRQRGGGNSSTLDKSDSNTRNPLLQDQAWFQPYEGDTLPVFVSEAACTGFATRLCQCLDGDSAPVSHIPRNRYIAESTLTQVTHAGIQWPSLIRARLLVKTALDHASPFFHVALRKPSLDYLQTIYEQPDTDPVLMCKYFALFALGEAYSSPNNRSNQGLVPGMEYHARAMNLIAVLPERPTIVHIEALLILALFSQFLNRWHSAYLMVGNALRFALLVGLNHNIPDNQCPDPTAREHRLRLWWTIYIFDRFWGLKLGLPVQLSDDDIHVGLPMDLDTPTYTEDFVPSLYQVAFIKLAQISTRIMRTIYSRTQFTETFLQREQRLLIELRQWMQSLPGPLRLQTNQPNPKGNILIHLQFNYCVILAIRPILLRILDNLALSPQTTISPTLAALKDACIHSARHMLVLCADEWTNGSSATYGYAFAQYSFTAALILIIACLVPDGGVGNTAVEDLTSVQTATEMLSSFAANGSLVADDLYRHLVRAQQCLRTGRFASQVPFHPSHHSSSYGPPSAGMQWPIFPSIVASSTPGRGAGDVLSRNAETALDETRIQEFVAQPAEDLGLLDSLDMMSGSELDMWLGLPLWTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7S8</accession>
    <name>A0A317X7S8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_458446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471106.1">
        <property type="nucleotide sequence ID" value="XM_025607792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7S8"/>
    <dbReference type="STRING" id="1450535.A0A317X7S8"/>
    <dbReference type="GeneID" id="37109935"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="216" mass="23981" checksum="E5DA4DD967F136DE" modified="2018-10-10" version="1" fragment="single">LAIGSNVAEEPQGKALVDESLKQGVKFFVYSSVDRGGEASWNNPTNVPHFLRKHNIEHHLADRAKGSGMEWTILRPVAFIDNLVPGFLGKVFVTAWEMALKGKSLQVIAVSDIGHFAADAFLNPEAYKGKAVSLAGDELTFDQMVQVFQQKTGQRLPTTFQFVCSLLLATMKDMGSMYQWFHDEGFGVDIGELRRQYPGLKDVGAWLEQESKFVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X814</accession>
    <name>A0A317X814_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_532723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470543.1">
        <property type="nucleotide sequence ID" value="XM_025611180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X814"/>
    <dbReference type="STRING" id="1450535.A0A317X814"/>
    <dbReference type="GeneID" id="37113323"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050068">
        <property type="entry name" value="MurA_subfamily"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43783:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="690" mass="75399" checksum="32D73A0BCC0E1BAF" modified="2018-10-10" version="1">MQTALHQPMGMTLLADAATSSLTALKGSASSAFSSTSQIVPPEPARTVVAVYTPGQEAIVQVVADILGKPWTTETSLSTFGRGSNAVVVGFLATEDSIRGLEVDDHTACILVNTHCVDDGSFPDDALTDRCHYEFLYSLRSPFFRRDLTRFLSLILGQTRPHEDLKTKNRTNFISTTFPDVHAALPNLDILSVGSDAVEIRVDLLIDPEPPQGAPASVPSLRYVGQQLMLLRQHTEMPIIFTTRCTKENGKFPMEDPLLFYKYLRRAIQWGVEYIDVELWLPEDIRRRLSEVKGNSIIMSAFHDFSGTWRWTSAEAPRIFAESAKYADIVKMIAMVNTIEANYELEYFRSTIKGTHGSYPLLSAVNMGQMGQLSRALNTVFSPITHPLLPMIAAPGQLTAAEINEALHIMGQLPKRDLYAIGSFRSTPQSMFMEKCFNELSLPHTLTSIDRGPMGSIERVITQPTFGGASVHPPITSGTTSIPTISEAAQAIGLVDTIVAVRGSGAQPQLIGENAAWKGIRATLTRDYVPSAYRGRAAIILAGSESEASATIFALRSLGVGAIHTVGFRARGPLAEGLEPFTSIQSVKMVEQPFVMVSALPPEKSLLVQPLLRHYRTSGRASPPSTRGKVYLDLTRGERTGDPVGVAERAGWTAYGIEDVDAWTTVETLRLLVGQNVPFDFVRMASGRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X846</accession>
    <name>A0A317X846_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mannan polymerase II complex ANP1 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_350897</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ANP1/MMN9/VAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470498.1">
        <property type="nucleotide sequence ID" value="XM_025607097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X846"/>
    <dbReference type="STRING" id="1450535.A0A317X846"/>
    <dbReference type="GeneID" id="37109240"/>
    <dbReference type="OrthoDB" id="204164at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000017">
        <property type="entry name" value="Mannan polymerase II complex ANP1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052086">
        <property type="entry name" value="Mannan_Polymerase_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083">
        <property type="entry name" value="MANNAN POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43083:SF4">
        <property type="entry name" value="N-GLYCOSYL-TRANSFERASE (AFU_ORTHOLOGUE AFUA_4G06870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03452">
        <property type="entry name" value="Anp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="411" mass="46878" checksum="E8EB2FAFBACC0529" modified="2018-10-10" version="1">MLLPKGGVTWKSAKARLPPWRAVLFLVTRTRFLVSLAITGLVVLLWRGISKSASEMQSFYCYGPSKSPMEMSINEMVEWSAHTQTPVVFNHHDPYEVNSSSIKTVDLNPIKSTTQAVSNSERVLVLTPLRDASDHLINYFNLLYKLTYPHDLIDLAFLVGDCSDDTLAVLTAELARIQDQVDEKIAFRSATIVQKDFGADTEMNVEDRHSFAAQGPRRKAIGRARNYLLYSALKPDHSWVYWRDVDIFDSPASIIEDFIAHDRDILVPNIWFHRYRDGVDVEGRFDYNSWIESDKGRRLRETLDPDTVLAEGYKEYDTGRTYMVSMGDWRKNKDEEVELDGVGGVNILVKADVHRSGINFPSYAFENQAETEGFARMAKRAGYQVYGLPNYVVWHIDTEEKPGNLGDRKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X854</accession>
    <name>A0A317X854_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RlpA-like protein double-psi beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_447909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470518.1">
        <property type="nucleotide sequence ID" value="XM_025607526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X854"/>
    <dbReference type="STRING" id="1450535.A0A317X854"/>
    <dbReference type="GeneID" id="37109669"/>
    <dbReference type="OrthoDB" id="623670at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="10934" checksum="E8238192F1000F36" modified="2018-10-10" version="1" fragment="single">SSGYSGSCSGGAPCTGDLTYYVAGLGSCGSYSNGSSDKVVALPVGIMKDSDCGKTVHITYNGVTETGTVLDKCMGCDDVSIDLSEKLFGYFGTEAEGRLKGAEWYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X975</accession>
    <name>A0A317X975_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_218982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471877.1">
        <property type="nucleotide sequence ID" value="XM_025606208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X975"/>
    <dbReference type="STRING" id="1450535.A0A317X975"/>
    <dbReference type="GeneID" id="37108351"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="621"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="886"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="911" mass="101479" checksum="5D2BE8631C698491" modified="2018-10-10" version="1">MPSKAVNYPLNTQQKEQDINQKLQLYGIYQAFKNGKLPSNKQCDVALNSALTSKALSSPSQELSGEGQALVKDLRHVIEHAKKLVLSKNEGQLLQEFLWEAQNISSGDTEKPGVPVTKDSAQQDAQEALEGLKTLGRLLITNGEFRKLLNDAMTLARDMAGDVSQKAADRVRPSADQLAQIDEPAEENVWHEQPDFSKHKDQFRARFKRNKDEVADTTAQAATRGQEPSSVSDVDARAGVAAGAERAQQKASETVPEETKGRAREYRERTKGYLSEKVPQERREQTIWRLKKMVIEVQGHSDYQQAIRTLLSMAEKYGGHTRNLSQQGAGSVQGFRSGDKIQRMETNLRTLLERFANNTSLDNLFDSLDNIYRDADRDPELKGWFKNMDTFIRKTLTEQGYIMDDDCTRQWDQLTDHGRYLLRDRYRDHTDRILDEMKFIGDQFNKDPQNKAFGDSVQKLFDDLGRDTSGNMAFKKHLLRDIRDVILPAILEDVRYVPVPRIEVSDPSADVVVENLVIESDNLMPNVVEFGSDNYFRWGRKKISNKRDNKVLKIMISVSGIQADLRDVSYYINRKQGFPAITDTGVMDIFLGGEGFGFKIAASTAQKEDRQNYIKLEKVSVKIDSFNVKLKQSKHKTLFTIFKPLLFRVVRPTLQKVLEQQIRDAFAKGDAFAYDIQSEAKKAQEASSQDPANAPNIYSRYLDAFRARNEDKRRKAQEIAKRDTKVQTATTLHESLFPEIKLPGGITSKATEYKELAMKGERWESPIFSIGSASESTDIPKAGEISRKRASPAEKGGVDGVTNGGATSNGVTAQNGVTNGRHTNGGATNGTTAVTGAPTMTNRGGKAMDGRVTNGRHAVPDSNGHAKAYDHAAASQKFSDEVNQAFSNGHAGTGAHTTVRGAETAFNPQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA62</accession>
    <name>A0A317XA62_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_531310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472150.1">
        <property type="nucleotide sequence ID" value="XM_025610874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA62"/>
    <dbReference type="GeneID" id="37113017"/>
    <dbReference type="OrthoDB" id="4831122at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016419158" evidence="1">
        <location>
            <begin position="20"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="241" mass="25614" checksum="B7A935831A3FC76F" modified="2018-10-10" version="1">MKLPLLIPLLYATLSHAAATTLCGPDEAILILENNTTATIKKADLASYLPNISFLPPNTTTPPLLTTTTTNTNHTKRGSSTELIIELPDLDFLGWDIAMSTVTHANQADATLAIAGGQMIANSIAIGASADFTLVEDFLSASYSLTYTQTVTSTLTGTVTMTIPANKWGAIVSNPLTHRKRGYVFTGEPGNGQFEYYQADSFDSASYTYSAGTLSWVKGVVTTCLGDGYPLPRCEGSGDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAM3</accession>
    <name>A0A317XAM3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis acuK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_621141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471443.1">
        <property type="nucleotide sequence ID" value="XM_025616979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAM3"/>
    <dbReference type="STRING" id="1450535.A0A317XAM3"/>
    <dbReference type="GeneID" id="37119122"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="492"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="545" mass="58641" checksum="83ABD53B2125C32D" modified="2018-10-10" version="1">MQSLVLPPSSFIATEFGHPRFNPGPERLPLNLPRSTNARRYPPRDLPLPRSMSGSVPADDPLETSGNTRRPGHPELPQPVTTVTATTSISAGLSGPVLPPGSTHEAVAQRMISASGNDTLRQPFSVGDTFPSSRLPPSLVGPGIPQAAAAAYAQPSFGTSPPGTTTRALPQKPTRRTKAHVASACVNCKKKHLGCDPARPCRRCVLSGKEATCVDVTHKKRGRPPLKAEEASLRTYAAHIDNRATAGEQHGPQSRRSLHRATSSREIRPMTDLQMPGGQAGAMAMRASAGHPQRWAASVYPQAIDPTITMQRGLGHRRFSSSGSAQSLAAASPPSFVPMPVGYNPALGAGRMPMGVGRPMSSYTHQGMNPATTPPQYQQPFVPISPYPESARMPNRMSMGESPMSRDPREGYLESPVRLPPIYPPTMGTPASASQGHRLSDPYPAAWSPRTREEFLQQEHRQQMASHGLIDPLSPNSQMRHAVSDFGYGEPIPRQFGPTGSAAERHSLHMSLVQSQDEPPANEADAEGNRPAKRRKMALDDMVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBM2</accession>
    <name>A0A317XBM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BRCT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_483593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471843.1">
        <property type="nucleotide sequence ID" value="XM_025608928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBM2"/>
    <dbReference type="STRING" id="1450535.A0A317XBM2"/>
    <dbReference type="GeneID" id="37111071"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000066">
        <property type="entry name" value="BRCT domain protein (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="104"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="341"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="615"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="858" mass="95520" checksum="A0BEEAC7A896B30B" modified="2018-10-10" version="1">MADQEEELQLFSQCKVCIICSKDLSADTAHQLASTVEEYGGETVIYEPPATFPPLSEFTHLLSCTVDFPAFDAASDALIPVVKPHWLHACLSKRKLANPRQYSPDPRLFLNDVVITCGDIPGGDKEAIIGGVLAKGGIYSPKVSQQVTHLVDLTADSDKARLVVAKKLNIKIVLPHWFDDCLKLGRRIDERPYTLPDPEILRAAPDAPIRSSENRDIIGASTTNPATLPSSVKSPETQPSLTVFQDKHVMLSSDLGIGPRLLGSIEEIINNGGGSVTTDVSKADILICRYREGFAYRTASRLNKDVGNLSWLYHMMTYNTWTSPLRRLLHYPVSRSGIPGFKGFKVSLSNYVGEARAYLENLITATGAECTKTLKQENTHLVTAHGNSEKCAAAKEWGLHVVNHLWLEESYAKWKLQPVSDPRYTHFPKRTNLGEVVGQTRLDRSILESLFFPSETQARVTASPRRAMQTKEQNTVAKSTDTMQPPSAKVTESESEVPPPQSATPRPVGKSRKAGETPKLQTPRARLASEGKENETPSTTSSRRSKDAATARLHEIAPDIALYEKEKKRVGGVIYGGRRKTDEDRVTLNNSKKRRSMEAGEESDEEDTTEAKRQKKSKPPVAMHLLITGYQKWVGNAKKEDSDKRQLRDLGVLVVQDARRCSHLAAPSILRTPKFVNALAYGPVIMNIEFITQCLKRDELLDPADFPLKDEASEKKYGFSLEAAKANAKQNKNKLLRGYQIYCVETIRGGFDAFKSIVDANGGECSLFRGRVSYRSQREESDESSGDDDRSRKETYLLSSTAVDHVKLWPRFRQMVLSTGKTPRIVRVDWLLDIAMSQTSHTADAYELNEDMAEDMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBQ5</accession>
    <name>A0A317XBQ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_141754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472710.1">
        <property type="nucleotide sequence ID" value="XM_025605728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBQ5"/>
    <dbReference type="GeneID" id="37107871"/>
    <dbReference type="OrthoDB" id="4505295at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="378" mass="43816" checksum="E87327B3DD5C096F" modified="2018-10-10" version="1">MCVIEEYTDVYPADVRRRRVLQRCLLGKSVGYCYRTTVINLGERCHDQPPRQFRYDQPGSEMSSLRHRIIDPREPARKGSPDYPRRQSRRSSRFRLLFPFLRRVPGSDEEHEERIPRGRPRSRLSTSTPDIPIPPIEREPRATPRRPPQIRVVSPRRTVIRERPLPRRPQMPLPRDEPRPRPPRTPYPVVIHQEPVARPARYRRRPPPPPPPPQPSSTVPPATFHMQPPPTPPPKKSRPPRERSPVAEREPIRKPRSTPTTPVQVHNPSTPCTEQHPGSRVEPRHVRFSDTVDHVSLSSDGIPSPAMPSRYYSRFRSSAIHGDHSPSSYGHQRSNSPFPEQREAHRQAYRYAYPEMRSHSSPAQPRPRTDGLYRSASM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC80</accession>
    <name>A0A317XC80_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM-cenC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_570589</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473005.1">
        <property type="nucleotide sequence ID" value="XM_025614826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC80"/>
    <dbReference type="STRING" id="1450535.A0A317XC80"/>
    <dbReference type="GeneID" id="37116969"/>
    <dbReference type="OrthoDB" id="3565477at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016378164" description="CBM-cenC domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="CBM-cenC" evidence="4">
        <location>
            <begin position="38"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="380" mass="38723" checksum="82248A2F221578E2" modified="2018-10-10" version="1">MLLPTTLVLTSCLFFPFVTAGTTVITGTTESCTTTAEFLTNPSFDTGSLSPWNAMTGFGSASVVEDTADNRGHVATLAEDQTMSAIYQTVTGLTVGASYTLSYDYMIKSAGMVGSAAFYICVDGIASANRLTLQGVTYTAAGTSWETISTTFTPTSDSHEFYILVYVVRSSTDPEILLDNAQFLAVSEEDDLETCTTSTYTTTVAVSTSSSSAISSIPAPASSSSAIATVSPTIPTSTPSHSSVVPAASSSPSRSLISSSGSVAASAPLVPVSASSRVIQSSPSSSLSSSSSLVQSLHSSSNVIRSSTMTPSKALASSSLLAVSRSISASTPVIRSSGGAKVNTPPAVSTPTSEPDEVVTVVSTVYTTLIATVLGCSASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDH7</accession>
    <name>A0A317XDH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_15163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473350.1">
        <property type="nucleotide sequence ID" value="XM_025605802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDH7"/>
    <dbReference type="GeneID" id="37107945"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016266515" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8805" checksum="00B2EB22946A8348" modified="2018-10-10" version="1">MRLFSFGSLCWCMGVGICFEYMTSAFEKLSDMYTAVCYIRSERFCWILPGVIGDSGMSHYTYRCQPFEYESIYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDL6</accession>
    <name>A0A317XDL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_482447</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472458.1">
        <property type="nucleotide sequence ID" value="XM_025608892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDL6"/>
    <dbReference type="STRING" id="1450535.A0A317XDL6"/>
    <dbReference type="GeneID" id="37111035"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="122"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY95697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="165" mass="17689" checksum="392059A39D7FD11D" modified="2018-10-10" version="1">MSSLRFARSALRARPSAFRVPLQRRGYAEAVSDKIKLSLTLPHQSIFKSAGVVQVNIPAESGEMGVLANHVPSIEQLKPGLVEIVEEGGASKKFFLSGGFAVVQPDSQLSINAVEGFPLEDFSIDAVRSQITEVQKIASGSGSEQDIAEAKIELEVLESLQAVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF41</accession>
    <name>A0A317XF41_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1688-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_552013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473118.1">
        <property type="nucleotide sequence ID" value="XM_025613569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF41"/>
    <dbReference type="STRING" id="1450535.A0A317XF41"/>
    <dbReference type="GeneID" id="37115712"/>
    <dbReference type="OrthoDB" id="2153176at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012469">
        <property type="entry name" value="DUF1688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31687:SF3">
        <property type="entry name" value="PROTEIN URG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07958">
        <property type="entry name" value="DUF1688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="501" mass="55120" checksum="3D278991DA342FA1" modified="2018-10-10" version="1">MGLFKRKDSKNSIQSEKEDLDSSVTINSARTSNASLRSPGYKGSGLPASIPELPIAKPPDPALDPAAYLRSIHAIRERCKLVLNQAKRNRLNHFDVDMGKFMATASYIVSIIKRDYAPDYDSIPPHGRWQHFDVGGRPRVNQLLQSWPSTIDAQERTRRLIDLFVVSVLLDAGAGTRWSYKSKESGKIYSRSEGLAVATLEMFKSGLFSSDPTEPCQVDGAGLKKISVDVLAKGMQHSESNPLAGIEGRAGLLIRLSEALNNQDFFGVDARPGNMLDYLLSHPSTLASSVPIVPITTLWSVLMDGLSPIWPPSRTQIDGLSIGDAWPCSDLPRSPPAKPWENIVPFHKLTQWLCYSIMVPMSKLMKIHFAGSELLTGLPEYRNGGLLIDMGLLSLKEKELERGVAAFKENAQIKGQPNMEVVPLFSTDDDVVVEWRAVTVGFLDELLDEVNGQLGLTGEDQLTLAQMLEAGSWKGGREIAEVSRPNTKEPPIMIRSDGTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFJ3</accession>
    <name>A0A317XFJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_530248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472281.1">
        <property type="nucleotide sequence ID" value="XM_025610642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFJ3"/>
    <dbReference type="STRING" id="1450535.A0A317XFJ3"/>
    <dbReference type="GeneID" id="37112785"/>
    <dbReference type="OrthoDB" id="566238at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE RDL2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44086:SF10">
        <property type="entry name" value="THIOSULFATE SULFURTRANSFERASE_RHODANESE-LIKE DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="233" mass="24730" checksum="47711310B2DA28CF" modified="2018-10-10" version="1">MASLLPLRRAPSTLLSSTSTSTTTLRPITTTLTLTRPFKTRRPSTTTPITRTLPLTTTPSSTPAPSTPSPSAKNPPPEQQTANPPSANGALKTYAPSPFPIHPTQTNTSIPPQITASLPTTTPSPPSTAQKSLILIDVREPAELNSTGIIPSAVSVPLASQPDALFLTEEEFETRFGFPKPGVKGDGEIVFYCKAGVRARAAAQLAVQAGYEADRIGVYDGRGRVERWEGEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFR9</accession>
    <name>A0A317XFR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Leucine rich repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_131779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472391.1">
        <property type="nucleotide sequence ID" value="XM_025605649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFR9"/>
    <dbReference type="STRING" id="1450535.A0A317XFR9"/>
    <dbReference type="GeneID" id="37107792"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="272"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="610"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY95630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="803" mass="87983" checksum="BB266DD0F042491E" modified="2018-10-10" version="1">MEKLNTEDGQLFVKNLASFVRTHEKALANALQLRRQPTKNAQSTHTQSASSGSASSTLAAALSFGALKFTSQNVKPAKLTLTPHHLFYLLSRFEELSIAVGPLNVRLENIHTDGSQSYVSFLNKPQRSRGDRDSIHSVSSVRSVMSGMSSLWSSIGLGSKDSVSKSEKAKAALEADTKYLYSAFTKIPCLRLAPDRRARLIRGYEEFPFDTAVPLHSFKNLSALEIIDIDFRSFFGWDRLSEQLRTLTVKRANIEDPADLLTGIVLDDIDKRRRRSSKHHHSPMMSWAGNANPQPVHKSELSGSLSAPGSPVADAPFGTSSSPQAASMIRMASEGSKARPRTGSISPSRPTSSKHSTYRHSRGNVSRIRRTGSGSSNSSETSGHRNGSSTNLVLPASKWRFLRHLGLPDNSLTSITAAGLAPVANTLQSLDLSTNLFTEVPDSLASLVALRALNLSHCMIESLHSVSRNPLPAITALNLRGNRLRSLAGIERLLSLERLDLRDNNLTDPTEIARLTNLPEIREIWVSGNPFVKTHSNYRVVIFNLFRRTPGYSEDIIIDGSGPGYTERKQLVDRAAEPEAAPVIRSVAADLSAVVSKPMHTATQEPPLLHEQVGHVGRVGQNGIEVGSTRRKKGARRKIADRPQEKPSTDGHRDSGAVVPSIPSAQHVQLPVDPFITASPDRQWKSDGGPQDRPVSPKSADKTDVDRDSSALQAKDRLGLQPGPQSKDWGVDGDFYRRQLEVLRQELGNSWLRTLEDHRWKDAQTDINVSCTGPDYHDPTRIPVDTLIRVNPQVILSGGHALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFV0</accession>
    <name>A0A317XFV0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_552270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473468.1">
        <property type="nucleotide sequence ID" value="XM_025613591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFV0"/>
    <dbReference type="STRING" id="1450535.A0A317XFV0"/>
    <dbReference type="GeneID" id="37115734"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000388">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000451">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="31"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY96707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="573" mass="63240" checksum="04A97C36A54041D2" modified="2018-10-10" version="1">MVVSQSVVGRANAEKPHGLAGMLKNPYVFGTCAFASLGCIMYGYDQGVMSPVLVMENFENHFPYFMGSTIQGWLVSALELGAWAGALFNGYLADRISRKYSMMVAVVIFTLGSGLQAGAQKPSYFFAGRIIGGIGIGMFSQVIPLYQAEIAPPELRGSLVSLQQLSITIGTSIAFWLDYGMQYVGGTTCNPEGIDNPYLSDGTYNAAQNHGHTCLGQKTIAWRLPLALQILFAWILFFGMFFFPFSPRWLMSKHREEEATAALSKLRRLPPNDPLLRAEILEIKAAVLFDEESEEEAIRSGGKLAPWKALFAPNMLKRLVLGCGTMICQQFTGINAVLYYAPQIFASFGFSSTKQTLLATGVTGILQIIFTLPAVLLLDKFGRKTFLIAGATGMFLCHIVVAIVEGLYEDNWNKNEGLDKPQGWVAITFIWLFAVNFAYSWGPVAWVLAQEIFPNSTRSRGVSIVASTNWMFNFVIGLTTKDMLNSMKYGTYIFFAIFSALGGLFIWRFAPETKDKTLEELDIFFGGGMDSIAEKDRVRMQRINERLGLAGMQEVGDLDVGEKGDVKGEVVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFY6</accession>
    <name>A0A317XFY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cycloheximide resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_507564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472839.1">
        <property type="nucleotide sequence ID" value="XM_025609621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFY6"/>
    <dbReference type="STRING" id="1450535.A0A317XFY6"/>
    <dbReference type="GeneID" id="37111764"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="144"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="583" mass="63753" checksum="89AD734824E91A16" modified="2018-10-10" version="1">MARVFSNSAIGVILRLVSGGRLFTPREYRRDFTLPPPYQLAASNALAQQQQQQSPEKTAPSADGSTLFNQALPRDDPVKEIDGIQDVTLPTPAPTPPSSSSLQSPSSSWIEPEVMPDGTILVDWYSPDDPDNPHNWSFAAKLLVYVEVNLFTFLVFMAAAIVAADEGQIQDIFGVSRTVSSLGLALYVLGYGMGPMIWSPMSEVPEVGRNPPYVISVTIFLILAVPTALVNNVPGFLILRYLQGFFGSPGLATGGASLADVTAIKNLPYGLYIWGMCSIAGPAIAPTISGFSVPVKGWHWAMWEILWAAALCFVMLLFLPETSGPAIMHLRAKRLRKLTGNPAFRSRSEIQTQNATAMQIAYEALVIPWKVNALDPAVLFTTVYIGLVYAIFYSYFEVLPLVYQDIYHMNLGQLGLIFLSCVVSSLLLIPFYYAFVHFSLNKAFRRGEFPHPEHRLVPAIVGSVLIPAGLFLFAWTSRASIHWIVPTIGLVIEVAGMSLVLQCIFSYLSVAYMTYSASLFAMNDLARASLAFAAILWSGPLYDRLGVARGTTLLAGLTVGCIVGVLVLYWFGPSLRKRSRFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UT33</accession>
    <name>A0A317UT33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_629363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000081">
        <property type="protein sequence ID" value="PWY64288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461276.1">
        <property type="nucleotide sequence ID" value="XM_025617558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UT33"/>
    <dbReference type="STRING" id="1450535.A0A317UT33"/>
    <dbReference type="GeneID" id="37119701"/>
    <dbReference type="OrthoDB" id="2012566at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY64288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="53798" checksum="408C05AC7FC7BD38" modified="2018-10-10" version="1">MIKMTPQKQPQYKAIIFDLGGVLFTWEPSKDILITPILLQSILSSQIWHDYKRGTLTQEDCYQALATQFSIDVSEIALTFNQPRQSLTTNLAGMTLILEMNTIVPKIAVYAISKPDDAVLLQTNPKACIFDRIFPSGLHSARKPQLGFYQKVLDEVRIPPEQIIFIDNQLGNIISAQSIGMHSILYTQPSLLSQNLKNSILDPVQRGMEYLRRHAKALHSTVDDGQVVLENFSQLLILEATGDETLISLKHHESTWNFFQGPPTFTTSTFPDDVDTTSLAWLILPAPKPMISALLDRITTSLVNEDGIVTTYFTPHRPRTDPVVCTNVLRLLHKYNYNYNTTLPSTLHYIHTTLHHRTYLHGTRYYPTPESFLYAVSQLCAQDPSLTSLKEVLVERLQERMNVEVDALALGMRILACLSMGFTRGEVEGEVEELVLRQCEDGSWPAGLFCRFGVSGVGMWNRGLGTAVGVRVLRVYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVI1</accession>
    <name>A0A317UVI1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_504500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461544.1">
        <property type="nucleotide sequence ID" value="XM_025609509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVI1"/>
    <dbReference type="STRING" id="1450535.A0A317UVI1"/>
    <dbReference type="GeneID" id="37111652"/>
    <dbReference type="OrthoDB" id="446368at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000266">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="72"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="521"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY66034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="608" mass="66131" checksum="5C6DE7126EF4E53D" modified="2018-10-10" version="1">MGTAGTVANGDAPRPSKIPFWRLVLDQKVVTPEIVDFPYEGSGTEESPYVVSWIPNDPRNPMNFRVLSKWLYTALVAFVTLTTALVSSVYSGGMSQVVKHFQCKEEVAILGISLFVLGFAFGPLLWAPMSEVFGRRNIFMGTFAVFTAFNAGAAGAQNIQTLVIFRFLAGFFGSSPFGNAGGTIADMFPAAKRGIAISFFAAAPLCGPTIGPIIGGFLGANAGWRWVEGFMAALSGVLWLCLCFLLPETYAPVLLRQRAAKLSELSGKVYRSKLDIDNGKVSLRRSLKIALSRPWLLLFFEPIVLLLCIYMSIIYGTLYMLFAAYPIVYQEGRGWSEGIGGLAFLGILVGMVIAVALTIPHNLEYSKKCQVKGRLPPEARLPLCIVGGIALPIGLFWFAWTNYPSLPWIASVAAGAPFGFGLVLVFLTVFNYLIDAYTIYSASVLAANSALRSLFGFAFPLFTTYMFNNLGIHWASSIPAFLALACVPFPIILYLYGARIRKRCLYAAQAEAFVQKLMQQNQAPPQEKSDVEKGDPATVSDDDVSDNESLSTGPSGGAAERRASHVSRKTGHSITRTVTYEENPYDIDRVNTCNSTISGRPPKNSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWV5</accession>
    <name>A0A317UWV5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_504263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461701.1">
        <property type="nucleotide sequence ID" value="XM_025609501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UWV5"/>
    <dbReference type="STRING" id="1450535.A0A317UWV5"/>
    <dbReference type="GeneID" id="37111644"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF5">
        <property type="entry name" value="O-METHYLTRANSFERASE ASQN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="191"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY66503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="421" mass="46794" checksum="255BB2FC738774A8" modified="2018-10-10" version="1">MSIPSSNLADLAAQISQATDQVNAFLVANGHPQPSFDRDAPPAFPEAPAAIQAARQQILDACQSMYDALVGPAEHLRWMACRYHDMSSLRWLYHFNIAAAIPLDRAVPYSEVAATANVDGNRLKTVLRLAMTNRLFSEPRPGFVAHNAASALLVTSPALNDWVGYTTEESYPASVKLVEATERYGSSQLANHAAYNLAFDTDEPMFVHLQRFPERERRFANTMVEMTSTEGYGVHHLVDGYPWEEIEGTVVDVGGSTGHASIAISHKFPTARFVVQDVEGVVEQGRAVLPAALTERVTFQTHDFFTPQPVSADVYLLRFILHDHPDARAVQILQNLIPAMKKGSRVILNEGVLPEPLTLGRGEERTARIMDMEMITSFNARERPLEDWKKLCQDAHPGLKLRRLFKPAGSIMSIMEFVMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UX53</accession>
    <name>A0A317UX53_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein SQS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_504582</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SQS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000055">
        <property type="protein sequence ID" value="PWY65939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461518.1">
        <property type="nucleotide sequence ID" value="XM_025609512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UX53"/>
    <dbReference type="STRING" id="1450535.A0A317UX53"/>
    <dbReference type="GeneID" id="37111655"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02646">
        <property type="entry name" value="R3H_G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034082">
        <property type="entry name" value="R3H_G-patch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051189">
        <property type="entry name" value="Splicing_assoc_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14195">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="11">
        <location>
            <begin position="499"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="10">
        <location>
            <begin position="626"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="301"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="582"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="336"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY65939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="669" mass="74251" checksum="04ECEA81C917E4E3" modified="2018-10-10" version="1">MTRSTKAKSRNRKQRTTADDYLGHHNGQLTMQQEARNTEGRNLWRTGASLRHQTVRFVSAQDPQPDRETEHHSVSTKNLVEMAQPKETLEPQIPSETMVALAPEPILEDKDRSQCIEVVDHISTPNQVVGFKSQTSVDSSEDEIVFRGRRNEQDDSKNPSIESQEQHTTTVTSGLQHRREIEHVQSGHQYFIFDTGLSSVSRDDSTESHPRARGDSIGYISLRGGKQKQNNKKWERDEDDILADYIQNIDDDYLMLTSTLHPTRGQGYDSRASDSAGSMTNLDPVTSAAAKTLVLHQETTFPRCDGLTPEEKHESDGTDTSFPGQTCREAAAEEGATQNQNPQTHSGPAASSGISDTEDEEKDGLDVSSKSSIGRGKVMLQSEAQHGSATDFMQTLHTLEQGFFASATAFADALEFDPYYGFDIMDFNRPSVKKKPKGKNHALDITLSDSELESELINAWQNDRAKKKARKQKREELRSQGLLGRSREEPVLKTKYTNGIGFEDLKTEFRKFLSSSKNSLALPPMSKQHRKLVHELANALSLSSQSRGKGSSRFPIVHKTSRTPAYTPKTISQMDRILFKRYSQRGTKSRDMKSTKSIKSRRDRPDASVSYMDGDVVGGSAPEIGAGNKGRAMLEKMGWSTGTPLGATNNKGILLPVAHVVKNSRAGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXM5</accession>
    <name>A0A317UXM5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Myoadenylate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_480184</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000059">
        <property type="protein sequence ID" value="PWY65277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461402.1">
        <property type="nucleotide sequence ID" value="XM_025608781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXM5"/>
    <dbReference type="STRING" id="1450535.A0A317UXM5"/>
    <dbReference type="GeneID" id="37110924"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01319">
        <property type="entry name" value="AMPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.800.20:FF:000001">
        <property type="entry name" value="AMP deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000214">
        <property type="entry name" value="AMP deaminase Amd1, putative (AFU_orthologue AFUA_8G02860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000035">
        <property type="entry name" value="Probable amp deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01429">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="990"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="991"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00078830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY65277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1011" mass="113602" checksum="423783C6C68995B4" modified="2018-10-10" version="1">MTSSRSSHAPRLDANASTPQDLSKNYVDQQTYNKNATSPLFVPGDDGIDHTETNNSDLDSAEKAPGNILPRDRQLKTPTYDYAFEKSMSHAEAKLFYQHHQIASRNVDGECPNEISAISSSVGDTDPKDMAGSPPAIGLGALPTTQRNLSSPNGNRIFDLPASQQAPEPHGAHLIVRQDDESTLPCPDNMGNVSDSLGTAQGLMNISADSSAVTSELNVICRKIRGLLDRRSKYMQLSLQGPEDNPKDHPGWEVYPPPPEPAWDNEKDIGKSADSSRVDQKKRKMGQDIGEDFDMAQCLPLPQESSWVYRLDENSVYQVYESDAAADSRRPVVNIPSLRDFYMDLDAVTDVSTDGPAKSFAFKRLSYLEGKFQLYALLNEYQEIADCKKVPHRDFYNVRKVDTHVHHSACMNQKHLLRFIKSKMKKSPDEVVLFRDGKHLTLKEVFESISLTAYDLSIDTLDMHAHTDSFHRFDKFNLKYNPVGESRLREIFLKTDNFIKGRYLAEITKEVISDLESSKYQMVEWRISIYGRSIQEWDKLAAWVVDNKLFSPNVRWLIQVPRLYDVYKSSGMMENFEQVITNVFQPLFEVTRNPDSHPKLHIFLQRVVGFDSVDDESKAERRLYRKYPIPREWNTKQNPPYSYWIYFMFANIASLNTWRKRRGFNTFVLRPHCGEAGDPDHLAVGYLCCHSISHGILLRKVPLLQYLYYLDQIGIAMSPLSNNALFLTYDKNPCANFFKRGLNVSLSTDDPLQFAFTKEPLIEEYSVAAQIYKFSAVDMCELAKHSVEQSGFELSLKRRWLGNDCCLRGVPGNNVAKSNVPDIREQFRHETLIGELTLNICIDCVMFRIDRYAHTGDDATIRLKGLAAVNHPGPLPSVQPNAGVRSDSNSGPLICAEELSKSEQKAKVEVCNLATQPGSQNTMKGACIEGPTLQDLEANAVTTPGEFATSFGSTSTAGITAHSADCVPEQKIFPGIVHERAHRHNMPIEGLAEDDKEEGSGDSEATSSFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYC6</accession>
    <name>A0A317UYC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_540645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461623.1">
        <property type="nucleotide sequence ID" value="XM_025612960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYC6"/>
    <dbReference type="STRING" id="1450535.A0A317UYC6"/>
    <dbReference type="GeneID" id="37115103"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF96">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY66359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="31964" checksum="5EC410E55CF759A2" modified="2018-10-10" version="1">MPSSNSSSVAPSPASFHLADGLGYALQQSHRSVIRLNLQHFLWRQVFGYSIHPSIPTTPALSKVVDVACGTALWLIDVAHENPNGIQLDGLDLDLTQAPHPAWLPSNVHLDQWDLFTPVPQHLQEQYDLVHVRLLVLVLSGLDPLPVIRRLYQLVKPGGYLQWDELDCVNMCIKKVDPSIAAPALEEIRVGSHADGRHDWVLDLPRLLAEAGFEEATIDHYDEPPEMVRAFNDQHLLTMEEFATRLAGQGQHKAAARFTQLIQVGYQESVNGAALSFPRVVVVAKRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V156</accession>
    <name>A0A317V156_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_628707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462086.1">
        <property type="nucleotide sequence ID" value="XM_025617503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V156"/>
    <dbReference type="GeneID" id="37119646"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="110" mass="12137" checksum="36ADDAA9363C2BC8" modified="2018-10-10" version="1" fragment="single">MCDVGFKHQFHKIGPAASSVCLKVAKLKLLDQFGKFTAQIKGGKYGYCQAFYQKKSGYVDATRAAAIGSRLQMKKMVLLAGSCSACNCLLFSLIDRALFCSDEWTHFDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V1H2</accession>
    <name>A0A317V1H2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Extracellular serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_479047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461885.1">
        <property type="nucleotide sequence ID" value="XM_025608730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V1H2"/>
    <dbReference type="STRING" id="1450535.A0A317V1H2"/>
    <dbReference type="GeneID" id="37110873"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF8">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_6G00670)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016357124" description="Extracellular serine-rich protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY67241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="37341" checksum="CF3E655D1C1D87D3" modified="2018-10-10" version="1">MVSHLLAIAAMLATARAQYSSTDVPSSTTSTTRTSQASTTTTTSTTATHTVQVGSKEDPHQYLPHNITAAVGDVIVFEFYPRNHSVVKADYLAPCVPASGTIFYSGIFNSFNEQDGDLVGPPPTWSLVVNDTKPTFFYCTAIDSCIGNGMVGVINPNATMTWEAQYEKAKTYPYMLVPGQSMPAEGTIPPSSSATSTSTPSSSSSHSGLSTGAIVGIVIGSVAFVGLLGALFFLLGRNRVYKQWMSSQDGRHERTARWAALLSPSSGNTNTGPRKSEMEHSTGMPQSEFPGSMGGMSPPQQQTGGGLWGWDSTQPQPQPQHQVYQGPGHGQGQVYYEAMARGPSELEAPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V592</accession>
    <name>A0A317V592_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-specific glutamate dehydrogenase</fullName>
            <ecNumber evidence="4">1.4.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_540055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.2" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462391.1">
        <property type="nucleotide sequence ID" value="XM_025612831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V592"/>
    <dbReference type="STRING" id="1450535.A0A317V592"/>
    <dbReference type="GeneID" id="37114974"/>
    <dbReference type="OrthoDB" id="184415at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056365">
        <property type="entry name" value="NAD-GDH_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016210">
        <property type="entry name" value="NAD-GDH_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055480">
        <property type="entry name" value="NAD-GDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF24">
        <property type="entry name" value="NAD-SPECIFIC GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23147">
        <property type="entry name" value="GDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23152">
        <property type="entry name" value="GDH_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000184">
        <property type="entry name" value="GDH_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="730"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY69186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1099" mass="124124" checksum="407C3146995A439C" modified="2018-10-10" version="1">MVSPAPSSSPLSDGHINGNNTLPMRTGPKLYGSNDGSQSGAGTPIGFQRHPHNKFFDNVAGSSVRQPSPQPTHLGIPGGGQHRILSEEDPGYVAAKFEGKEKQMEQVMDQLEKKGFLPLEFVLGETEWFYNQLGIDDTYFQTESVDAIVTQILSLYAAKVAAYARDDKKLEIRLDKEAEDHAVYIDTSKPGVSTVEGPGYEQRIDKKYINSSTHENSYRVETFRSPTPIPGDDGQQLRCYFVYKCQFANPNPDPNETNIDIIGEKRFLQKATPNTKAIYQEIISNAVSRSGPVIEMFEIEKSREKRLVIAYRQGSAMGLFSALSDLYHYYRLTSSRKYLENFSNGISVISLYLRPLPGKEIVQKYPPIEAAIHQIIKEVSLLYCIPQNRFQHHFASGRLSLQETIYAHCAWVFVQQFLNRLGSEYTSLTDLLDSNNSVHAELLAKIKKRLRTETFTSDYISEIVNKYPELIHKLYLDFANTHYVQTRGPAEDDFLPTLSYLRLQVDEVLDGPKLKQLISSSAANEHDEMVMSAFRVFNASILKTNFFTPTKVALSFRLNPDFLPEHEYPQRLYGMFLVISSEFRGFHLRFRDIARGGIRIVKSRNKEAYSINARSLFDENYNLANTQQRKNKDIPEGGAKGVILLDVNHQDKARVAFEKYIDSILDLLLPPVSPGIKDPIVDLHGKDEILFMGPDENTAELVDWATEHARNRGAPWWKSFFTGKSPRLGGIPHDTYGMTTLSVRQYVLGIYRKLKIDPSTIRKLQTGGPDGDLGSNEILLANEKYTAIVDGSGVIVDPQGLEQEELVRLAKKRATISEFELSKLSPQGYRVLVDESNIHLPSGELVHNGMIFRNLFHLRSDQQYDTFVPCGGRPESIDLSTVGKLIQNGKATIPYIVEGANLFITQDSKLRLERAGCILFKDASANKGGVTSSSLEVLASLSFNDEEFVENMCIREDGTVPTFYGEYVKQVQEVIKHNATLEFEAIWREHEQTGLLRSVLSDRLSVAITKLDEELQKTELWDNVELRRSVLHDALPKLLLEKIGLDTILQRVPENYLRAIFGSYLASRFVYQYGSSPSQFSFFNFMTKRLAQLEASHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6G8</accession>
    <name>A0A317V6G8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_503291</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462200.1">
        <property type="nucleotide sequence ID" value="XM_025609469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6G8"/>
    <dbReference type="STRING" id="1450535.A0A317V6G8"/>
    <dbReference type="GeneID" id="37111612"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF37">
        <property type="entry name" value="ABC1 FAMILY PROTEIN C10F6.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="171"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY68537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="661" mass="75447" checksum="EAFC71844715C2A9" modified="2018-10-10" version="1">MASATVSRALRSFPSQLARPRLPRAPRFLPPLARHVHPGRYQPFVPPSPVSLGKPTPAKTYDRTRKWLRRFVYLSLATGVVYVLDTQFYAASLTRTARTFSLGLLVAIDYKINFRPNPPLASSINAVHTRNAERLSDLLRHNGGLYLKIGQAIAMQSTILPPEFQKMFSRMFDDAPQNDWKEIEKVIREDFGRSVEEVFGVSFTGEPGKGVMERAARASASVAQVHWARLPDGREVAIKIQKREIAQQLKWDLWAFKVVSWIYSRTFDIPFYSLVPYVSERLSLETDFENEADNSENMARLVAGESRLRGRVYIPKVYRELSSKRVMTAEWIEGVRLWDKDSITRTWRGGWRTGTPGCHGTPLDPRNAENPVAKFARNPQLTSKIKPERDHWRGGYARAGLGLSLKEVMTTMVDLFSAQMFLWGLVHCDPHPGNIFIRRTPSGHPELVLIDHGLYIHMDTEFRHQYARFWKALLTFDNTTLTSVVRGWGVQNTDVFASATLMRPYHGGDLSTRRSFEGLSKAERATRHYEMQQAARKAIREVLGDEEKWPRPLIFIGRNLRIVQANNQFLGSPVNRVKITGTWASRALVESPDLPTGEKLRNFARHMLFRVVLFSTDLFFWFTKVRQFLHLGGGMEDTIEAQMQGMAKDLGVELSQNVFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7H0</accession>
    <name>A0A317V7H0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_527516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462313.1">
        <property type="nucleotide sequence ID" value="XM_025610389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7H0"/>
    <dbReference type="STRING" id="1450535.A0A317V7H0"/>
    <dbReference type="GeneID" id="37112532"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY68998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="169" mass="18939" checksum="C5BB838CE8F60070" modified="2018-10-10" version="1">MPPPQTTHIFTLRVQAGTESLNASHPQSKISRHITSLVGGFLRGVPGTRAEGFNATLVTGGSDWVLRDEASNIIHLDVRTQGRTDSGDGVYIQYKGHLVLDKQSRKFMSRDGDAEMTAFGDHDWWVVVGFEVSDPGYEWVQRTMFFGRGRFYVEGDLRAVEYEVFAVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8I2</accession>
    <name>A0A317V8I2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_424934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462439.1">
        <property type="nucleotide sequence ID" value="XM_025607433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8I2"/>
    <dbReference type="STRING" id="1450535.A0A317V8I2"/>
    <dbReference type="GeneID" id="37109576"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY69611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="224" mass="24916" checksum="B337D670F5391A67" modified="2018-10-10" version="1" fragment="single">LGYNEAVNCLAFSPDGKYLATGSARGGGQSLNYPPSIQLWDIESKTLVHTLQGHYGVISAMDYEPRRGYLVSGGRDATVRIWDMNKRTLIQTLTMDRSITSVSMSVDGRQAAIAFINAPVRVVTVPDGELMGYPTGLEVYDNYIWSGHCPKTGKSDEAVTKLWYPNATHTVLLILTWYMFQVRVNCTMFTADSEFIIKGTEDSTVQLWNLETGEQHVELKAHQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBT4</accession>
    <name>A0A317VBT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP-type transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_539411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463059.1">
        <property type="nucleotide sequence ID" value="XM_025612701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBT4"/>
    <dbReference type="STRING" id="1450535.A0A317VBT4"/>
    <dbReference type="GeneID" id="37114844"/>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY71823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46437" checksum="C8F006ECF95A1E67" modified="2018-10-10" version="1">MTSMNGGPMPLDVSTANRQTLPPEAMQSQSGSRPSTLSADFFKFFSGTQKKVTRDGQPAKRRGPKPDSKPALTRRQELNRQAQRTHRERKEQYIRALETEVSRLREAYTQEISAANLTVVQHRDMVQSLSDENNILKEILTAHGISFEADLERRKAERSNLGYQSSPFASSSVGSQPAGVAASNPSNSNMYTTPPTTVSASLSPITNGIENIDVSPMQELTPLQGPYQAAPCDALATLDQIAPASRAPTQPPGIFEEQPQLQVDFILTLESPCREHTDYLCRRSITEADDEDMPFSGHALMATCPPPTYIATTTNEQVYPHKTYDLPHANLTTLLNLSRQLVTDGQITPIMALQCLKNHEMYRNLTRDDVKIIIETLNTKVRCYGFGAVVEDFELMDCLSSVLGSKVDRGLSHAGDEMYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCN8</accession>
    <name>A0A317VCN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Small oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_560125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463087.1">
        <property type="nucleotide sequence ID" value="XM_025614126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCN8"/>
    <dbReference type="STRING" id="1450535.A0A317VCN8"/>
    <dbReference type="GeneID" id="37116269"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="581"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="722"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY72134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="786" mass="88546" checksum="B4812F1515965CB1" modified="2018-10-10" version="1">MSEKEQAYSSAVADEASPEVAAVHLKHLKEQHHWDPNLPDEIADEIDEALTTDDKGARVGMTAELLENSPYPEVRAAVANFDEGGHTNTIRAWTIGMLFATIGSALNMLFSMRDPYIVIPSYVAQVVAYPVGVAWARWMPATQFSFFGIQCNLNPGPFSKKEHCLIVVMANATFGGGAAYATDVLLAQRAFYKERYGWAFEIFMCISTQMLGFGMAGFFHRFLVTPAAMIWPSNLINCTLFTALHDHSKPDPSKVSGWKIGKYRFFLYVMIGSFCWYWIPGFIAPFLSIFAWVTWIKPQNAVVNQLFGGATGLSLIPMTFDWTQISGFNFSPLIAPWHAIANTLIGMFIFFWVVTIGMHYSGIWWFKYLPISDSNSYDNTGAQYNVSRIMNADYTLNLKAYQEYSPLFLSTTFALCYGLSFASIIAILVHTGLFHGKELWVRFRNFGKEEEDVHSRLMARYKPVPLWWYGAVTLIMIGIGLGMVLGYPTHLSWWAFFVSLIMAVVWYVPIGIVQAATNIAIGLNVLTEFIVGYIQPGKPMAMMLFKTYGYMSMYQGLYFNQDMKLAHYMKLPPRVTFSAQMVAALWSSLVQIAVMNWGLATIKDVCSEHQANNYTCPNGRVFYQASVIWGLIGPQRIFSPGQLYSPLMWFWLVGALLPIAIYLGARMWPKSPIRYINAPLIFGGAGLIPPATPLNYLAWGMVGIVFNKWIRDRWRGWWMHYNYVLSAGLDVGLDLCTILIFLTLDLTSTSFPTWWGTSITGATMDMQGTAVQKFVADGETFGPKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCS0</accession>
    <name>A0A317VCS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_501260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463117.1">
        <property type="nucleotide sequence ID" value="XM_025609428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCS0"/>
    <dbReference type="STRING" id="1450535.A0A317VCS0"/>
    <dbReference type="GeneID" id="37111571"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05269">
        <property type="entry name" value="TMR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="311" mass="34656" checksum="519771D8E242C948" modified="2018-10-10" version="1">MPLQYLLTGSTGGLGSQILSHFLTLLPKNNFAASSSNPSNSERFTSQGIQFRTVNYDDPATLETAFADVENLLFVSTNTFDVERRRRQHWNVVDVARRVGVKHIWYTSLAFGGFDSHSKASVQQAHLMTEEMLRGSGVTYTSIREGVYTDAFPVFMNWYPSTTTLYLPSSTRDGKIAFTLRSELAEATAKLMIQGGHEDQIVLLTAKETITFGEIVGIINETTGREVVLEFVDPETYVRVCAETDEGGKKEGFFRQLVGWYEGIGKGELETTDGLMGRVLGREPVGARRAVRELLEGVKGGEYVWHQNYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGV3</accession>
    <name>A0A317VGV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTF2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_590051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462835.1">
        <property type="nucleotide sequence ID" value="XM_025615991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGV3"/>
    <dbReference type="STRING" id="1450535.A0A317VGV3"/>
    <dbReference type="GeneID" id="37118134"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY71080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="57102" checksum="0227D2B555BB97E5" modified="2018-10-10" version="1">MSLKDVYRRFLADPRSAPLASDASLIYITTTTKLDGASAVVNHLTKQQKGIKTKSENVLDLIESANSLCLDIETTLEFVSGNGGAYLPSLDDNFLAGHVATFPTIHIVRFNSQNQIQNVRIYWDQASLLKQVDVIGSRGRAWPVREPKDQIRLIKSSVASGPADDGPAPTSSLPTETAKESNDREEPSKQASPGKKHIKDPHAADSLFELLSPGKDRSDPVRPPRAPASAQPQQREYNEIFGDHDDVDLDAIEASPSRSKNTARTGAGKNYQGSRIFDNEEAGAGEGGHEQIAYRAHPKRFDHFELGADNSQREIHEKPGRPVSRQAPHWDFDDFVTPEKPKRQLRGEEIRHFGWSDDEPDLTSPPVRPRVVHARPDAETHFQLTDVQEEDKNGPRIISSYQNKGMGLYKNHLFNDNEGNENAPLSAVNNGPNRKNEFETHWSMADSPRKHQPNRENQKPIPGDRQRALKNMESSWDTIESPKPPVKMTPPQRRSVRSVNQRSWDMGENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHM2</accession>
    <name>A0A317VHM2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial F1F0 ATP synthase subunit Atp18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_627558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463618.1">
        <property type="nucleotide sequence ID" value="XM_025617430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHM2"/>
    <dbReference type="STRING" id="1450535.A0A317VHM2"/>
    <dbReference type="GeneID" id="37119573"/>
    <dbReference type="OrthoDB" id="5520611at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006995">
        <property type="entry name" value="ATP_synth_F0_jsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28060:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT J, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04911">
        <property type="entry name" value="ATP-synt_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6215" checksum="C958ABA5DDF0C156" modified="2018-10-10" version="1">MSLLGKKFPTPVAKPLAPFFAAGVVILYGVNSFANVLMNTAEFKNDPRNPNAKNQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJI9</accession>
    <name>A0A317VJI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_589175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463686.1">
        <property type="nucleotide sequence ID" value="XM_025615933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJI9"/>
    <dbReference type="STRING" id="1450535.A0A317VJI9"/>
    <dbReference type="GeneID" id="37118076"/>
    <dbReference type="OrthoDB" id="5367135at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50720" checksum="1B5A39D532D38724" modified="2018-10-10" version="1">MSDEESFELNPLVWDPSRSRLPEKEESWGLKKARTQDREDWVVRLKFKQDGEPDEKVGTGFFLNIPGAEWYVILTAGHNLVDKSGHPSKDLIIERHKHKYPIEPLDIPPFVCPLYHRERGEQGPDHDYGVILVRRQFETNKNLRKALDLDLGFGFALNLAYENLESKTLELTGFFPHEEDKTGRKVQSKEQELEPLSTSSGECRIARESHLEYDITTDKGLSGSPVFMPYNGHETVVAVHNNGPARRGKGSTGARINATVLKQIFEWANLSQHHKALKAASDKSEPDPLYLHFPPYEDLAWVHWGKEGMNTAFDVFPAYAPTPLVDVSMLHVFQHVPPPDWPEARKDQQWVLWDVMAKGVTLTDTLQQFCFVELKQSKKGKMFTVVVRLEGGRDQSMACLVVNGDDITELDRETDTFDGSNVSLEKYIKNLPLKYNTFCWDDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VN06</accession>
    <name>A0A317VN06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_538646</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463660.1">
        <property type="nucleotide sequence ID" value="XM_025612534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VN06"/>
    <dbReference type="STRING" id="1450535.A0A317VN06"/>
    <dbReference type="GeneID" id="37114677"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF16">
        <property type="entry name" value="LYSM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016375355" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="34"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY74467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="229" mass="24039" checksum="3F405F9188B45325" modified="2018-10-10" version="1">MRGIFTALWAATCLMTGHAISDVNMPSRNCLSGNTYTTKEGDTCDSIALAHSVSAATMSFTNPNILNCSSIRPGTPLCLPLECDVYTVQPGDTCTSIALGVYSSTRKILSYNTQLNWDCSNLHSPDPYWGSTICVSVPGGKYPGQALNASSSEPGAVDPPSGATVASGTTMVCGAWLINDVDLDISCAQICLAHKISINAFTAANPSLGKRTCDSDLVVGDAYCVRPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQ40</accession>
    <name>A0A317VQ40_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_538352</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464289.1">
        <property type="nucleotide sequence ID" value="XM_025612474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQ40"/>
    <dbReference type="STRING" id="1450535.A0A317VQ40"/>
    <dbReference type="GeneID" id="37114617"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016485894" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="29"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY76476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="332" mass="38958" checksum="2B71DB1AFCAB9228" modified="2018-10-10" version="1">MALGTARRKTYWCFIFLLLAALIGKSTASLGDHLPDFKECVKVCQAENCQDGNSAIPFHLRLMLWTCPSECDYTCQHVVTDRRVARDPPMLNPVLQFHGKWPFRRILGMQEPFSVLFSFFNFLAHWYGIGRLRETAPSWHSLRSYYIVFGYFGLACWTFSMLFHTRDLSLTEKLDYFGAGANVMYGLYLAIIRIFRLDQEEPRHKPTLRRLLTTVCALLYTLHVCYLSFWSWDYTYNMIANIVIGMAQNVLWVGFSIYRYRKYGKEWMAWPGMIVVWIILAMSLELLDFPPWHELIDAHSLWHLGTVIPTAWWYLFLIRDIQNDVAGERLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQC8</accession>
    <name>A0A317VQC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_210854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463884.1">
        <property type="nucleotide sequence ID" value="XM_025606157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQC8"/>
    <dbReference type="GeneID" id="37108300"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY75257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="96" mass="10527" checksum="7033D2DA3251E541" modified="2018-10-10" version="1">MNSTPDLEGHYSRLGAGNSELRGTEPKICSGLPVRCEVDIQSVLWTVHLLKSLQSAITLSEKLLGHRVFVLSVLQIASGFLFWPTGMNLTGYKPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSP9</accession>
    <name>A0A317VSP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_605297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464054.1">
        <property type="nucleotide sequence ID" value="XM_025616480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSP9"/>
    <dbReference type="STRING" id="1450535.A0A317VSP9"/>
    <dbReference type="GeneID" id="37118623"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016357139" evidence="3">
        <location>
            <begin position="24"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="125"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY76057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="586" mass="63738" checksum="E760735676781193" modified="2018-10-10" version="1">MKASAMVSQLLFLVLILTNLSSAGDRTWSWTVLNATLQGRLHAASPLAQPCFSHYDGRPVSPQPSQCSELQAQYTTAAYRADLYNGFMHAQNEICAASSNPITSQCLLDPSNPTDLAAVLSHSCGQGSVSRYYIPVHEAADVQTAFEFARHTGVALSVKNSGHDFSSRSSLHGSLALWTRPLQNLAFHPEFIPEGCPIAPSASHPAITLGAGVNFDQVYRFAHQNNVTFIGGTAPTVGASGGLAMTGGHGLLSAQFGLGIDRILEYQIVTPDGQVRRANACQNTDLFWALRGGGGGTYGVVLESTSSVEPRLPLVFAYLTVPANVTHPDAFAQLLMEHAVRWSQQGWGGPNSMNSLVMANPFLNLAAARASLAEAIDYVKAQPGGTVVFESYPDFFPVYEAYMLPTANAGVGQARFATNRLIPTAMLQNATGRARILDTLNQLVAEGYKPTLFATPPSDIHSPYTDPGSTSATPAWRNSTWMITTEAQWPWNSTLTQRRAFVRRLKAVTRALERLAPDSGSYISEADPFTDNWKTSWWGENYAELLRIKQKYDPDGLLRCWRCVGWDEQWEQPGGRFDCLGGLLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSS0</accession>
    <name>A0A317VSS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_499431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464074.1">
        <property type="nucleotide sequence ID" value="XM_025609376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSS0"/>
    <dbReference type="STRING" id="1450535.A0A317VSS0"/>
    <dbReference type="GeneID" id="37111519"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF2">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY76077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="419" mass="46851" checksum="A25CA10DCB3A117B" modified="2018-10-10" version="1">MTKHLRPSPQSLKYALKILIVGSGCAGPALAFWLSRSGHHILVVERSPSLRDKGAQIDLRGQGIEVVKRMGLLDTIRDKCVDESGFNLVDSNSTIQASIKANTSGKGRQSLTSEFEIMRGDLVRIFHDATNHKPNVKYIFGMTVDHFTQDTNQVMAYFSNGTSDTFDLLVGADGQNSQIRKAITPATAPDPYLHLGFHAAYWFIPRIESDTNTFTAYLSPGGRAIFRRSHSPTESQAYFFLKDPSPELSSIHRASTSQQKQFWTQRFRSAGWETDRFLDGLQTTENFYTQEIVQIRTDTWYKGRVVLLGDAAHCPAVITGLGTTSSVIGAYVLAGEIEKNKGDLEQALRGYERVLRPYVNEIQKLSTSVMTFAFPVTWWGIMLLQWVARVVCWLGIPELVTRFEGAGEKGGWKVPVYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSZ1</accession>
    <name>A0A317VSZ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_499537</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464134.1">
        <property type="nucleotide sequence ID" value="XM_025609382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSZ1"/>
    <dbReference type="STRING" id="1450535.A0A317VSZ1"/>
    <dbReference type="GeneID" id="37111525"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="542"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY76137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="572" mass="61791" checksum="A22CF8F0C338E2A8" modified="2018-10-10" version="1">MRYTDWVHRVNLAVARSPVGRWFRLENSGHPKERKGSFFFTELRAGLATFFAMAYIISVNATITSDTGGTCVCPPESYADQCNTNTEYLLCVQEIKRDIVTATAAIAALSTFCMGLFSNLPVALAPGMGLNAYFAYTVVGYHGFGMIPYKVALTAVFVEGFVFLALTLLGIRQWLARALPASIKLATGTGIGLYLTLIGLTYSAGIGLVTGATDSPIELAGCVDGLRDATTGLCPSDAKMRSPTMWIGIFCGGILTAVLMLYRVKGAIIIGILLVSIISWPRPTPVTYFPHTELGDSMFDFFKQVVTFHPITHTLVAQEWDISGHGSQFGLAFITFLYVDILDTTGTLYSMARFAGTIDPRTQDFEGSALAYMVDAISISIGSLFGASPVTAFVESGAGISEGGKTGLTSCMTGICFFISVFFAPIFASIPPWATGCTLVIVGALMAKAAAEINWRYYGDAIPAFLTIAIMPFTYSIAYGLIAGILSYITLNGIVWLIEKATSGRVVPPNKDEKEPWTWRIPGGFFPPWLRRAARGKRDFWREDEERQGLDEGSVESQGSAEKGVDVAGKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTW3</accession>
    <name>A0A317VTW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Only prolin and serin are matching in the corresponding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_200749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464205.1">
        <property type="nucleotide sequence ID" value="XM_025606093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTW3"/>
    <dbReference type="STRING" id="1450535.A0A317VTW3"/>
    <dbReference type="GeneID" id="37108236"/>
    <dbReference type="OrthoDB" id="3882058at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="54864" checksum="B66068AD8798ED2F" modified="2018-10-10" version="1">MLKPSQFLDTRRRDSFETMAESSPSSRLPPSPWTTTSSTPVSPAVSLFSAKGHTRFSSSVSSLVSSPGHGNSMESSSRNPLTGVKEEPCGAQPRDLEEDYFQHFDQGLSVVEDSYFASFDASDSYDLTDAGMDLAHSPRNRRSDSISARGLSRIGSRISTISTRWKSKRASDGPDSADVFTPQLRSRTNSASSAMASPTTGSFTRVNSIQIPPSPARTIFEEAISEAGTQPIDIVKANRHGQEDSAPHATTPLLPPFMGDQPSYPTASRVHSPLQSPSVADMTDDSPIVCSAITDLRLAGLPSPPLSSKPSVASFNRPRASTVRTVSGDAPPFTLSDPNDEWANKLGHANFTIQPEPYVPEICDLMSFRQLRTNWDLAQCNFTRHLVRTGEHYGVTSTIYKLTEEKWESINREWRRYHESMLSELEVTEGPRLSLMKSHCGPCDPVKIPRLHDDKFPELGDGEIVGPMKIGPAANGSGLCRSRSLKRNFVKFFQDLVIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUY2</accession>
    <name>A0A317VUY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_604275</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464348.1">
        <property type="nucleotide sequence ID" value="XM_025616457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUY2"/>
    <dbReference type="STRING" id="1450535.A0A317VUY2"/>
    <dbReference type="GeneID" id="37118600"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="626"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="808"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="533"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1071"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1080"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY77161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1119" mass="122989" checksum="941DD60B034A709F" modified="2018-10-10" version="1">MGNVGSRLDDSGNLYFKDQTRFTIASVTITNSKRRVLLNLVPNSFPATRYAAKRETGDESPIEYIQEPDLSPSTPVPTFLLRLNNEDELNFNFTFILRQTQTGNVANSTVNGVSTSLPEVTDTVLTGLTFAHAPNSKELDNLITREFHANPNLQNNSNVQLVGDYSTGGSPSVQFDWSWKWKPPKVVEDKGGGWRNSCSFLDYDQRANRLNTLAHFSFWVQNTVRSLPSPQISSPNLEINVPFRNRIPSSQSILSHSSDADATSNHQVVPATPPEASDTTAIPLHVSIPPPPVKVDLPHSRPGEDMSVVEDGPLFRATMKALEQKTGNMRAKIKKVLKKAEAAQQAQTVCNDAVEAFLFALTEASTSNANAIQPALDHYFEKTARQILNYERLNTVQLQKLVIDPLVRLYNNDIKQAEAKKKEFEEESRDYYAYVSRYLGQRQDSLKEKKRVESDSKYQAKRRNFELKRFDYSSFMQDLHGGRKEQEVLSHLTKYADTQAKSFLAAARNVDDMIPQLDALIHEVSQADKEFQFQRTEREEKRRNLEKSSNMYIEPDSLANAGAPPILSGNGGGNPKSEIELGRADSTGSQLRGVISNTSSILPQSNSANPSAGSPMLASTINSPGQQRKEGLLWALSRPGSHIDPKGINKQAWHKFWIVLDQGKLSEYSNWKQKLDLHMDPIDLRMASVREARNAERRFCFEVITPQYKRIYQATSEEDMANWIRAINNALQSAVEGRGMSPPPVSSDGDGTYLGRDIGSVLTGKSSSYSGQHSYSTASNNSVTRRTTVGARPSYVRGDGLGFEENPSKLLQAIRDADQGNHWCADCGSTSKVEWVSINLGIVLCIECSGIHRSLGTHISKIRSLTLDVNSFSNDIVEILLQIGNRVSNMIWEATLDQIQKPIATSTREQRLKFITAKYSDQAFVEPLPSLLSRFATPDETLLAAIKRNDIQGVLYGIALHANVNITDRSRNTHAVFLALAAADPASPGTTSNLPAKPSGASSVKAIPFPIAELLVQNGAEIPSQPPPIPLSSAAQLYLSQRTARVSAFGALPAAPAPGKATADSLGSLPTIRGAGNDITIPSSQPPSSLDSKEREKLHKRGSAGARFAGKVASLGIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWW4</accession>
    <name>A0A317VWW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_472595</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464591.1">
        <property type="nucleotide sequence ID" value="XM_025608441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWW4"/>
    <dbReference type="STRING" id="1450535.A0A317VWW4"/>
    <dbReference type="GeneID" id="37110584"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY78079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="399" mass="43900" checksum="28CCE8B0D878470C" modified="2018-10-10" version="1">MAPANRPMGPSTRALHADDALNVVSDVAPPMHVATTFRYSDNPDDLVPVADLSGQDQEKTTHIYSRLTAPNPTRFEAILSSLLNGEVISYSSGLSALHAALVLLNPRRIAIGNGYHGCHGVISLFTRLTGLQKVDLDCPVEQLEAGDVIHLETPVNPEGTAFNIQAYAEKAHSRGAYLVVDGTFAPPFLQDPFKWGADLVMHSGTKYFGGHSDVLCGVLATRRKDWAKQLSQDRVFLGSVMGNMESWLGVRSLRTLEIRVQRQSQNATSLVSWLNDALHAPSPAPDSDEAVVQRALERVFHASLQKEDESWLLKQMPCGFGPVFSITMKTEDFARKLPSKLAFFQHATSLGGVETLIEWRTMSDATVDRRLLRISVGLENWEDLRQDLVTAFGELVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZD8</accession>
    <name>A0A317VZD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sterigmatocystin biosynthesis P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_523106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464447.1">
        <property type="nucleotide sequence ID" value="XM_025610204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZD8"/>
    <dbReference type="STRING" id="1450535.A0A317VZD8"/>
    <dbReference type="GeneID" id="37112347"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000093">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF96">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE STCB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY77260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="485" mass="54157" checksum="17167645A9EBD833" modified="2018-10-10" version="1">MERQAALCVAIGMAIWVLQLAYNSLRSPLRHIPGPLYTRATRLPLKISIITGKRIYFIHDLHQRYGPVVRIAPDEVSISSLPEFKEIHRAGSAFLKTAWYQKTTFDRKPGIFAMRDPKEHSARRKLLARPFAKSELRRTWEPVVKEKVHLAVSQIRRELLSTGRSDVLKWWTFFATDVSGHLMFGESFGMLQLGRRTKYIDALESIMKGGGINAELPVVGLIGRHIPHPSFKAMFRSSDYLSEYGGRAVSNSRTNSMSTRNIFTGMLTESEKESGTLTEEDVVTEAGNLIVAGSDTTAVTLTYLVWAVLLQPALQHDLEEEVGRVDPSYNEAALEELPLLNAVIMETLRLYGAAPGSLPRSVPHGGGIFGGYRMPQGVTVSTQSYTIHRDETLYPDPESFDATRWLPGDGRDSDAARQGLSPFGHGSRGCLGIHLAWMELRLAAAEFFRECRGVRLAPSATWESMKPENYFLISPCGHRCEIMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W081</accession>
    <name>A0A317W081_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_522395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464887.1">
        <property type="nucleotide sequence ID" value="XM_025610180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W081"/>
    <dbReference type="STRING" id="1450535.A0A317W081"/>
    <dbReference type="GeneID" id="37112323"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46067">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46067:SF27">
        <property type="entry name" value="ACYL-COA N-ACYLTRANSFERASES (NAT) SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="91" mass="10300" checksum="72AD6AD09BFF36F6" modified="2018-10-10" version="1">MKYRTMKVGYWLSKSYWDHGITTAAVKAFSAWTFKTFPHLLKLKAEVFGDNTASARVLTKAGYTLEEQKRQAVEKNGVVIDLLVFGLVRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2Y5</accession>
    <name>A0A317W2Y5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidyl-tRNA hydrolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_537107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465558.1">
        <property type="nucleotide sequence ID" value="XM_025612191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2Y5"/>
    <dbReference type="GeneID" id="37114334"/>
    <dbReference type="OrthoDB" id="277888at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000065">
        <property type="entry name" value="Peptidyl-tRNA hydrolase domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052405">
        <property type="entry name" value="Mito_Transl_Release_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203:SF1">
        <property type="entry name" value="MITOCHONDRIAL TRANSLATION RELEASE FACTOR IN RESCUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46203">
        <property type="entry name" value="PROBABLE PEPTIDE CHAIN RELEASE FACTOR C12ORF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="6">
        <location>
            <begin position="45"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY80956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19995" checksum="88B016B68014A70D" modified="2018-10-10" version="1">MFRPLHLTPYIKFNRPFLTSNYSPSPRLFTLSALSLANKALPPRLKIQDADVTISYLKGTGPGGQKINKTNSAVQLIHKPTGVVVKSQATRSRSQNEKIARQLLADKVEQLLHGDQSRAAIRVDRARKKKASKTKKSRRKYRDLEDGKESLEAEGDDAHEQSPRQLPDRQSLQQEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W3H3</accession>
    <name>A0A317W3H3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="11">1.1.99.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_626250</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate. Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-malate + A = oxaloacetate + AH2</text>
            <dbReference type="Rhea" id="RHEA:67460"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67461"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.39" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465328.1">
        <property type="nucleotide sequence ID" value="XM_025617345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W3H3"/>
    <dbReference type="STRING" id="1450535.A0A317W3H3"/>
    <dbReference type="GeneID" id="37119488"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051990">
        <property type="term" value="F:(R)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="16">
        <location>
            <begin position="113"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY80469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="545" mass="59630" checksum="32D57AFDF37BEF32" modified="2018-10-10" version="1">MSGARNLSAALRRARVPKPRALLRPLTVHAPSPAATVARAFSVTSAANATKEIKYTSNAYPNLKRDPKFAEISAEDVAFFKGLLGAQSAVIDGVTADAADDIEPFNSDWMRKYRGHTRLVLKPQTKEEVSKVLQYCNEKKLAVVPQGGNTGLVGGSVPVFDEIVINMSRMNQIRSFDEASGVLVVDAGVILEVADSYLAERNHLFPLDLGAKGSCHVGGNVATNAGGLRLLRYGSLHGTVLGVEAVLADGTIVDSLSTLRKNNTGYDLKQLFIGSEGTIGIITGVSILCPPRPKAVNVAYFGLESYEQVCQAYGEAKGHLSEILSAFELMDGRTQKLVHESTGTHYPLEGEYPFYCLVETSGSNAEHDMAKLEGFLEHIMGEGTVADGVLAQDETQFHAIWRWREGITEALSHLGGTYKYDVSIPLPELYQLVEDCRERLTKLGFVGDDDSFPVRAVVGYGHMGDSNLHLNIAVRQYNKEVEKAIEPWVYEWIQKRNGSISAEHGLGLAKKEFIGYSQDETMVKLMKQLKGLYDPNGILNPYKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6M0</accession>
    <name>A0A317W6M0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_558301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465509.1">
        <property type="nucleotide sequence ID" value="XM_025614001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6M0"/>
    <dbReference type="STRING" id="1450535.A0A317W6M0"/>
    <dbReference type="GeneID" id="37116144"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031303">
        <property type="entry name" value="C5_meth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00095">
        <property type="entry name" value="C5_MTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY80907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="564" mass="64064" checksum="3FF997FF3B3A5450" modified="2018-10-10" version="1">MDIGSQSDSSVTIDNDPDQVLFIGRNPIYRPMIDLTQEGPKEGDYLTDAAYNSLLRNWHRNRPATNPTIDERPKRVLNGGRVNGILYTPGQSFELHNGHFIRVQTMFESATGEVMFNGRHLIRSERHIRTYLPKRPNELIWISNEPAEIPFQAIKRFVKINFTNYCHVDNDIQKEGRPHDFFCRLKEHVSMNMQEPSSLEFISFDEADEGFRHDPIVLRRTWRGETRSFGAADSPLTITLEDDGVVDLTEQGIRRDRRQYTFGDGFCGAGGVSCGARSAGLRPTWAFDNSAHAVATYQLNFNDAQCEGSDVFNFLTNNYDFLKVDITHGSPPCQTFSPAKTVESANDDANSACIFSCSDLIRRARPRVHTMEETYGLLERHKDMLYRVIQDFVEVGYSVRWTLLNCVDFGVPQYRRRLVIIASGPGERLPPFPNPTHGPPGSGLLKYATINQVISRIPQGARDHDVEGAYERMVRHRTPFDPDQQARTITCGGGERNYHPSGERGFTNREFACLQTFPLRFRFGPREVRKQIGNAVPPMLAEALYKAIKESLHQTDAKELGQQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9J9</accession>
    <name>A0A317W9J9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LaeA-like methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_520716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465382.1">
        <property type="nucleotide sequence ID" value="XM_025610123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9J9"/>
    <dbReference type="STRING" id="1450535.A0A317W9J9"/>
    <dbReference type="GeneID" id="37112266"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32616" checksum="71CEC258184CFE51" modified="2018-10-10" version="1">MDIHDKYVFGRDEVESKRLDLQHKLLVKVSANTLIHPTIPTENIHAIADIATGTGIWLEDVSQFLNLTTPHIQRYYHGFDISSEQFPTSNPESIHLSIHDLTVPFPTEHHNRYDLVHVRLLVAALEESEYRVAITNIYDILKPGGHLQWEELDSETYLTKDNNPVIEELYRCFDYGFRAEGKCFSASAKVYEESKMVGFVDVERVVYDSQRFPELREDTEKRLVAIIRSLYVRLLVRSGQVGSEEIARGRAEELVVRLGGLCEGGLASPGVKLMRVLGRRPLESLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WAP3</accession>
    <name>A0A317WAP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">R3H domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_123740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466064.1">
        <property type="nucleotide sequence ID" value="XM_025605591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WAP3"/>
    <dbReference type="STRING" id="1450535.A0A317WAP3"/>
    <dbReference type="GeneID" id="37107734"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="262"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="326"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="693"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="799" mass="85385" checksum="628A8EAE8D5C9CF7" modified="2018-10-10" version="1">MASNSSTRDDHRLSFAKIAAMPPPSIPEAPVLPDEVHGSQSVDGLSCSEQHGSEHVPSDQGASSNVRDEAATVDRNVDCLSQAVHNVHIEEKKYHGSPVFSGEAPDSGSLKRETSFEDDRTHLSNSSTKPTSFDSKSMASVTTFAMDEKDSLRPDDSASVQAVDEEESLSGPASGAPNSLTGSESGARGFRDLQRPRGILQPPGPIFNDGIQRTNGAVIPDTVANNYAVPNADAFLNGRPIHGFPSEPDEKLLEAMKSPKDRLLILQLEEKVRHFIQTSKEHSLELPPSNAFGRLLAHKLGDYYHLTHFVDNNVTSVRLHRTPFCRLPTPLSVLHAASSSTPPPAMPAMKIMRRTDSERPSTEGSIAASSSAPSKNGSEAGDSGDGERGGSSAGATPAKDRLALTREEREAKYQEARERIFRDFAEPKPSENANGEIGANMSRSSSASGRRKGHRQKTPHDDSFEARSQFNAYYPGMHYTNGTMPYGMAMNDPSFPNQPCMVGPGVSPPTMGYGPGGQTGPMYSGPMNMNAMPHYSMPVSPQMTPSGPWQNGPVPQQSPYSGYATINQSPAMASTKSSPALNSYPMPNSVQYPPNPGWSTPPYPGGYPQPSHRNPPPSAWASYQTQPPTPTSYPYTQYPGQPLSPGMQSHSVAHPLPGSFNRSPFNPQTRSFVPGSAPLARHPSKGSQHGMNPYPGIQPGIQPQWPGFQDANNKPQEASGSVGHGPSRGGPSGGRDSIAKWGTPSHLPPKPPPSEVPSDFDLKPRSGPNSTHPYSGNTLPTPKNGPLVVSGGATLPRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBW4</accession>
    <name>A0A317WBW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_586892</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466311.1">
        <property type="nucleotide sequence ID" value="XM_025615787.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37117930"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1313"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1317"/>
            <end position="1337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1588" mass="176094" checksum="6F3F8A2D891ABD82" modified="2018-10-10" version="1">MIFKNSSDVEYTNSVLSDGPGSSHDILHDDVTVRETSHLILSIILEHALNKFDHGKDRFEGIADTFLPIIDQSVAARTRIEACLPAFPFKSANKVYKVLGTLPDKAEELALDRLNRMCVRIKEVYPPGARITIISDGITYNDLLCISDRDTWAYGEALREMAVQKQFTNVAFSRIKDLLDLPLPKRMSEIVYIANCTAFRRLLLNKYGNPDLDIDHEIATNPDTKLTYLGYKRFLESDLKHILHIGRDKSAHSYKQDCKYLAKQMLIRGYAFAGMIKDAFPNHLRLSIHESLSGNKLSISLLNTMTGFTTPWHCSVAQLANGEWVSAPMGEFRKDDKLELVYEDGRPSHFRQKASERGAGATIETMASYLRPAKALNASEYLNRALSSPSVSAESSTGMTLETQSHPSLVLSDLDLMGDDKPSGESLPNPAGASGSIPYGKRLIPQIMDNLAATEPERTVFSLTTLSGGSLGFRHISASTFTRAVDKTAWWLRGQLGKLDSIQPVGYIGPHDLRHVLLTYACVKAGYTALFLSPKNNTEGVLAVLEATKCNVWVNACDVTPVPLVKEVLEKRPMTLLQLPLLDELLDATPTEPFLYIKTFEEARDDPFCLLHTSGTTGAPKPIPWSHGLIGTMDAVRLLPPVATHDYLPPWTTDWNPGDTIYSSFPMSHGAGIIMDILMPALFNLRCILGPVDVPPNINLVEALAGNTRVDIWSMVPSLVDELGETPVVLSKLKTSKFICASGGPVSPVSAGKVNEIIRVLNLTGTTEGLFIGNLVPPRDDWFWFCFHPYSGFEFKEIEADTYEHWVHRNEHWELFQGIFHTFPDRQSINFKDLYMKHPTKPNLWAFMGRSDDLVVLSNGYKISPLETEALITTHPAINGCLIFGTGKPQAGLLIELKDPSQKTDELLDRIWETVKKANSMSRHKGQLLRDFVTFATPDKPFLRTDKGTVKRGATLRLYFDYIERFYSSRGEDLTDSFDMNMSSTEAIQENVRKIFASSVPEVQHASLDTDLFALGLDSLGVFAAIKTIRTATGLGDSIGPRHVYASRSVNELSATIVRLAAEAESNSKTLSSPGNSSTANIEHAVAQHKARQSFSLNAFDYVNPNHGMGLVFYFSVREGVSYEQVFDNLQEGLNRTFDLIPALSGKMMNCSEQAIGYTKGDLCVTIPPLSEAASVRNRLVYKDLSAVLPSFDKLREGGFAPSAFKDSLVLRDDPFPKMPADIIIGQANFVSGGCILAVDLNHCCLDGLGAMVAIKAWAENCRYLQGDESATCSWYDPESFNHSLPEILHEQEGWARPLDTINPGTWGFLPFVPPDENSTTNTKSPDPNGVSDTTLSPRPLYPLHPIWPLPRAERCLKTTLLSITPENIEAMKQEVLSDPTTNGLITSISDILQAFIWRAAIRARYRPGRGLHPRTPRRRPPILLLPLTPTYMGSMLILNRCTMPIKTLCAPETTIGQVALMLRQSAARITPSLVHDAFTILQSLPDHSRFSTANMGLEHMHAMISNMLLFPADEIRFGTELFGNGGSPESMRPQLERGNGRFRFLAVLPMKRDGGVDLALGTHPEELQMLWADEEFVRYVDVVDVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBY2</accession>
    <name>A0A317WBY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_558070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465708.1">
        <property type="nucleotide sequence ID" value="XM_025613980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBY2"/>
    <dbReference type="GeneID" id="37116123"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY81640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="57009" checksum="96222A37402FDC7E" modified="2018-10-10" version="1">MKCVIESNDTCRRCRRSGLPCIFVPRANAATLPDGIMATRDGDFKDDVLRRLRIIEDRLGLSGASRPAVESPPSHNEDISPDFSGLGALWDAVVILERTAPSWIPGSVWRKSTVKGLWLSFHDRMPGLHFMPRKQTFSAPQPLLVASILFCSSVRGPPDVAEQASHYLSVVCHAIAQLSIPGSEVGKVPGDPEEWAFQTVLGLVLAGLLTEAVHRETGIWISIAYRLILENCPAHIDETSREWRKLFSGLQIIDLEHASLHLSCPIIPIECPLLGLQTSNRDQLYRLSRMMHTGLTHFTGRGLPTIWSCFTGQMPGPGSSTSNFTAVDAAVIRDWARQLDEWLVEFSHSAEGSEQDLKLVFRQYVLHRLVVLSIYHPARGCDLWSNSTTPQEQQELLLSARATLKLHSHDDSIWSNWDQVMITWAALIVIQGIEGGAGEPDDLLGIRIHLEKLKQVMGLGDKLVARLEASLTNVHTPVGPQDGAADTGIMGPADQSWQIFDQASLQSMMYSNWMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCJ7</accession>
    <name>A0A317WCJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol 2-dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_495208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465872.1">
        <property type="nucleotide sequence ID" value="XM_025609254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WCJ7"/>
    <dbReference type="STRING" id="1450535.A0A317WCJ7"/>
    <dbReference type="GeneID" id="37111397"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF7">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G10190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="2">
        <location>
            <begin position="214"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="370" mass="41378" checksum="81B75E8801AF97F8" modified="2018-10-10" version="1">MSSPQRLSVGIIGAGEVFQVCHGPCLLLLSHLFKIESICDLSPKTVDHCAAKFFIPHKTATPQEVIDNPNVQVIFILTSDDSHAPLAIASLKAGKNVFIEKPVSLSLPSVESIIAAEKAAPGNARVFVGYMRRYAPSYLQAFKREIATIPKILYARIRDFSGPNAQFVNQSGTFQVKHSDYPPHATEERNRCLDTLFAEVFPDQDITDEKKNYCRFLGSLGSHDISLMRETLGFPEEVVGVSVHDPFYSAIMTFRNEDGSTYAATYESGIDQVPLFDAHIAVYGAQKRVTIKYDSPYVKGLPIYVEVDELNEQGEIQRRTMLSSYEDAYTTELQDMYEAFANGKAIKTTVEDAKQDLQIFDMMYKKWGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDP9</accession>
    <name>A0A317WDP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIM-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_519833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465973.1">
        <property type="nucleotide sequence ID" value="XM_025610087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDP9"/>
    <dbReference type="STRING" id="1450535.A0A317WDP9"/>
    <dbReference type="GeneID" id="37112230"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.460">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034452">
        <property type="entry name" value="TIM-br_sig_trnsd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIM-barrel" evidence="1">
        <location>
            <begin position="9"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="280" mass="29962" checksum="7133619EA3BFAB71" modified="2018-10-10" version="1">MPRPTTRKEVLARLRKTIADGSIIVGAGAGIGLSAKFIEKGGADLILVYNSGRFRMAGRGSLAGMMPYSDANAVVLEMANEVLPIIQETPVLAGVCGTDPFRDMRAFLQQLRNTGFVGVQNFPTVGLIDGNFRANLEETGMGYDKEVEMIRIAREMDLVTTPYVFTVEEGEKMARAGADVIVVHLGLTTSGTIGAQTALGLEESVDVVQKVRDAVVKINPEVIVLCHGGPVAGPEDAAFVLKRTKGVHGFFGASSMERLPVEKAIEENARLFKGIKVGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE25</accession>
    <name>A0A317WE25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_108685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466558.1">
        <property type="nucleotide sequence ID" value="XM_025605490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE25"/>
    <dbReference type="GeneID" id="37107633"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14612" checksum="BC8993292E557763" modified="2018-10-10" version="1">MKSIPTGLQRRKELKTTACRSSRRIRDGQSRPESSSALLPCQDGFSGHDRSNAEAQVWIGSVSDLACEPINAVWLDEARTPPTSFHLMPSNGRSCTGLLLSFGVCCVWPEPALFPTYLVVAMRWTWIAWMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFG1</accession>
    <name>A0A317WFG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_586790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466206.1">
        <property type="nucleotide sequence ID" value="XM_025615779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFG1"/>
    <dbReference type="GeneID" id="37117922"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="103" mass="11757" checksum="3B4E51366476A422" modified="2018-10-10" version="1">MTQHPESNRNNLSSLLTICLLLHPPAPPLPVAGRLPHFQFALRDPFAKSSIVHGRFTRGKPLRLCAVFTRPRPRQAFTLRATAFNETQHHIGSYHWRLRAVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFZ6</accession>
    <name>A0A317WFZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin subunit 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_536589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465895.1">
        <property type="nucleotide sequence ID" value="XM_025612046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFZ6"/>
    <dbReference type="STRING" id="1450535.A0A317WFZ6"/>
    <dbReference type="GeneID" id="37114189"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY83110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="172" mass="18446" checksum="DF587E8E9525FCE7" modified="2018-10-10" version="1">MPPPNTPASDPPPGSVNINSLSVPQLRALQTRLSSELEHLTTSHAKLRAAQLKFKDCVRSINEGVIGSAKKGTDGKEDILVPLTSSLYVRGKLADREKVLVDVGTGFYVEKTAPKAIEFYEDKVKSLETNLTELEKIVQTKSGQQRLFEDALRQKLLAEGAASSATASAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHB8</accession>
    <name>A0A317WHB8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Fatty acid synthase S-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_624992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466891.1">
        <property type="nucleotide sequence ID" value="XM_025617253.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WHB8"/>
    <dbReference type="GeneID" id="37119396"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="45"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="927"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="927"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1066"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="959"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY85874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2482" mass="273313" checksum="11875CBF49BECDA1" modified="2018-10-10" version="1">MAIDNGSEHVVEAAIHIEDVRRQPHLDQPTTPWATNHGQEPAGLPPPIAIVGMGMRFPGNIRTGEDFWSMLVEKRSAVGEIPPGRYHGDSFYHPTRPHVVKTKHGYFFQEEYLGKVDPGFVGKPHEAGLLDPQQRLLLEVVWECMENAGQSDWRGHNIGCFVGTFGEDWLEVTSKDFQAIDRFRAMGTGDFALANRISFEFDLKGPSITYKTACSSSLVALHEACQAIQSGDCSSAIVGGSSIIFSPTMSVTMSDNLVLAPDGRCKTFDASADGYGRGEGINAIYIKPLDTAIRDGDPIRAIIRSTATNSDGKTPNISTPDRQSQETLIRRAYSRAGISDPCQTALFECHGTGTTMGDVTETEAVAGVFGEKGILISAVKPNVGHMEGASGLTSVIKAVLSLENRKIPPNIYFERPNPEIPFEKGKLEVPIDTLPWPEDREARVSVNSFGIGGANAHVILDAYQRRDSMPKPSSDGDHDQLVVVSAWGANALDKKIQQLQSYLDQHPEAFNDVAYTLGSRRDHLAHRAFLVTGGKIENLEGFQRAHLPESQASEIIFAFTGQGAQWSGMAKGLMERYPQFYRDVQIMDVTLRGLPSPPRWNLHDTLLNGNQSAMDRAECAQPLCTAIQLAIINILAAYNICPSKVVGHSSGEIAAAYASGAISMETAIILAYYRGQVSSQCEGKGAMLAVGLSPKQVRSYITGGIVVGCYNSPESVTLSGDSGALDEIAARIRADLPDALMKKLPVQVAYHSSHMMFAAAHYEELIRPHVTCKPNMIAQMFSTMTGQTIHNPTQLDAAYWRANLESPVQFTAAMGAALKSATDTPQPLILEIGPHSALSGPIRQISKDIEKRHSYCPTVVRGDDSTSTFLNAVGQAYLHGAPVRFTAVNGTGSCLNDLSPYPWQYENLGWSETRPPRQWRLRKFAHHELLGSRTLESCDSEPSWRNILRLDEVPWIWDHSVASQVVFPCAGYIAMVVEAARQVTESDAITLRNLLIRTALIVEPNMEYELLTTIRPVAINDLVESSWYDFTVYSYDGTSWKKHCAGQVKSGTSASLSQPSVLPVYPRSVSSSYLYRQLKKAGLKYGTTFQGLQEITASPSTYEAAATIQDDPQLHVGRYLVHPTAIDQCLQLHCVAACRGLAPGMSVVGVPSYIGEVYLTHSSETMSLGVSPTASNAITDGLGGDAHLIRSDGTTALSMRDARFFALESDGKSAREEPFLCSYMKYQPDIRLNPAKGLVKRAPVNTGLEITARLAVLAILDFDILVCNLTPTVPHMIKYRQWIQSEALQIKTSDYHCIEEARNWARISPGERLGLWKTLLEKVPDPRLSGFFADARYCLESEMDSLMTGQSSAAQVLTPRDSWKDIYGYGVDIFDWQQLFELLGHSSPQLRIVEIGAGTGSATAAALRALVDSRGDRSFARYVVTDITPGFLIPLQERYGSQLEYAVLDISLPPADQGFDVGGFDLVIASNVIHATPSLNKTLSNVKTLLRPGGWLVLHELSAAVPYVDWVMGTLPGWWLGDADQRLSRPYVTVERWNDEFVKAGFTEIEGMSYDEDFPYQMSATMVTRSAPSKPSIPVITLLGTLETQRQPWAAVIEDRLTLQGYTFQWCILGECPKESVVISLLDLDGPFLYDLPEESFSQLQNYLSIARRTLWITRLSHKKCSDPRFGLIQGFGRTIRAETGMDFRTVELDKFNDTSADVLMRVCEEFFDEKANPSGKDFEYSIEDGTVYTTRCNRLSMEEQLEVTGNDGPLRIHPGTRGVIDTLHWVEEEQQETLQPSEVEVDMKYLSLNFKDLMFALGLLGNNLPLGLEGSGVVRRVGSAVTDLHEGDSVIVIQQGTFKTRLVTQDLKCMRIPSEISLEQASAMPCVYATAIYSLLTIGNLSRGQSVLIHSACGGVGLAAIDICRMVGAEVYATVSSEEKIQFLIQTFNIPRERIFDSRSVSFRSGILDATHGRGVDLVLNSLAGELLHASWDCVAPMGKMIEIGKRDMLEHGKLEMVHFANNRSFFGVDLSEMLDDCPELVRGSINEMFTYCQEGRLQARLFPRMFDASEIAAAFRHMQTGRHIGKIVVKMPEVPHSLKNKPIERKYIFSPTRSYLLVGGFGGIGRLLATWMVTHGVRHLVIMSRSAGQSESDQGYIKELESQGCTVTVVNGSVEDTNTVEQAVSASEHELAGVVNLSLVLQDEFFANMSYDQWVGPQGSKIRGAWNLHNACSEKHLDFFVLFSSVVGTAGNPGQSSYGAANTFVDAFVTYRRGQNLPASRVTLGAVEEVGNFSRNTRLLELFHAQSRFSLSEKDVIDSFRLALPHTTTIPSQPQTTTQTPHPLDLMVGVTSFLNPGELDTKKSYYDQDIRFNIPSLMRPTKTPDHNQEDDVLLRLFESIANDPSFLNDPKCESIIIRELGKRVGNFSAQAGLDEKQIASFPIDSLMGLEVKYWIRRSLDLETSVLEIAQAKTVAGVAGLAMKGLRAKYGVGVPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJB5</accession>
    <name>A0A317WJB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_535575</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467010.1">
        <property type="nucleotide sequence ID" value="XM_025611820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJB5"/>
    <dbReference type="STRING" id="1450535.A0A317WJB5"/>
    <dbReference type="GeneID" id="37113963"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000145">
        <property type="entry name" value="Class III chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF63">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016443995" description="chitinase" evidence="14">
        <location>
            <begin position="23"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="30"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY86419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="357" mass="38892" checksum="D57CC5A085F14E23" modified="2018-10-10" version="1">MTFLKNLLAFSMGLASLGGAYAKLDLSSPDNVVVYWGQNSFRGTGDLAQQNLAYYCDDSNIDVIVLAFVMRVNGFGGAPEYDLADNSKDCPLFNGTNLANCPQVGADISTCQSKGKTIILSIGGATYSEGGFQSESAAQAGADLIWQTFGPAQSNSSAYRPFGDAAVDGFDFDFEATVNNMAPFANRLRQLSDADTSKQYFLTAAPQCPYPDLADQEILNGPVSIDVVWVQFYNNPCGLTSFIEGQDTQTTFNFEQWDNWAKNVSQNKNARVMLGVPADTTAASTGYVPVSQLQPIIQYTKTFSSFGGVMMWDVTQAYGNPGFLSGVRGALEQTTSRVQPTYRYPMRPWLFGPNKHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJH0</accession>
    <name>A0A317WJH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_575650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467195.1">
        <property type="nucleotide sequence ID" value="XM_025615088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJH0"/>
    <dbReference type="GeneID" id="37117231"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY86604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="270" mass="30145" checksum="2E54E4A410A7432B" modified="2018-10-10" version="1">MDLQSLLTNVTWQNALLVAGGAYILLNLKGLPFVWHIRLLNVLKSHILLHRPRTISITHGPHTPETLFYPVITTSRSPLLETDYNMHKSNATYFTDLDINRVHLIASLFKNQLSLGFSGGELGIALGSTACVFKREIKPYQKYEIHSRVLGWDGKWLVFVSHFVRPAARGVKGKVSGEGKGEVDEKRILASAVTRYVFKKGRVSVSPETVLTAAGLLPEKGVEGKEQEGGWSWERVEEERLRGLEIAKSFLALDELHQTFRGDGKAIGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKA6</accession>
    <name>A0A317WKA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_107620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466555.1">
        <property type="nucleotide sequence ID" value="XM_025605488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKA6"/>
    <dbReference type="STRING" id="1450535.A0A317WKA6"/>
    <dbReference type="GeneID" id="37107631"/>
    <dbReference type="OrthoDB" id="4207123at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095:SF1">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="195" mass="20021" checksum="03E646424297BE61" modified="2018-10-10" version="1">MSTNRPFLANFLAAFRAQSTYKASTAGSQTAGGPSSSLSSSQISQSARAIATKASGNTSSSDASPSTTTHHYHHHSTTSTSSSHSRPHSHHRSALNQPESSSGSPGPTQQAASSPPTPAASNPIPITNSHGRQRRGSDSSSGSGGFRDALGPEKWYIGGRTPGGEERFYRLGMVTKGGGRLGGSGRVGSIDQLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKV7</accession>
    <name>A0A317WKV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467332.1">
        <property type="nucleotide sequence ID" value="XM_025611731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKV7"/>
    <dbReference type="GeneID" id="37113874"/>
    <dbReference type="OrthoDB" id="10439173at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="114" mass="12064" checksum="B567834A9DAAE1CE" modified="2018-10-10" version="1">MGMDSGDRLTATTASSRGATDRRVATGTLSVRAGMSQNGRYPKRRVGEAFPEGGRQQEEGKQLATGRRSSPSSRRGQTCLRLRVGIFWLSNSGAGGAACPIRPGLIATEKLAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKY3</accession>
    <name>A0A317WKY3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cora-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_546875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466695.1">
        <property type="nucleotide sequence ID" value="XM_025613310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKY3"/>
    <dbReference type="STRING" id="1450535.A0A317WKY3"/>
    <dbReference type="GeneID" id="37115453"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000006">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.20:FF:000002">
        <property type="entry name" value="Cora family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY85678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="662" mass="74486" checksum="C8126264A2CEF604" modified="2018-10-10" version="1">MSESPKSEKYMCLTRYSTPVPELDDHRFQLDPPRFEATPDVPLSRQNTAPQGLNLETPQRQELLNIEDALREAGSLSRDFETAVVDDDRSDQDFNAMGRRFSVDPTGNIRHGRTYSRTHQELANLSRESSVSARSTSPPNSVEAFADPRRRERANTLESHAAPDLEAILQRTVSGGTHPRRPTFSNASVIRPQPGDITLEPTDDGCLPTFEQPGRIPVIDYEELEEFVALSQRAKPTANRRRHSLSSQSTKPRVFYDLRPGVQNSENDGVKRLSSIDRSSDDILDVPSEKNGKEFTDVVNEKELLATLKNENEPTRFGFFSSESQSTVHAAELGDLVLPGDTFRDLFQLGPDGGVWWLDVLNPTEDEVGALSRAFSIHPLTTEDILTQEAREKVELFKQYYFVCFRTFYQMDKTSEEFMEPVNFYMVVFRDGVLSFSFTENPHAANVRRRIGKLRDYVSLSSDWICYAMIDDIVDSFGPVIREIEVESEAIEDLVFIARMDDFESFLPRIGGLRKKVMSLMRLLGGKADVIRGFSKRCNEQYSVTPRGDIGLYLGDIQDHVVTMMSNLAHFEKMLSRSHTNYLAQLNVTNLMLGNHVNKVLSKVTLIATMLVPMNLICGLFGMNVNVPGQNAEGLGWFFGILGVIAAIVILSGVVARCYKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL38</accession>
    <name>A0A317WL38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO94DRAFT_71248</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467424.1">
        <property type="nucleotide sequence ID" value="XM_025617616.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WL38"/>
    <dbReference type="GeneID" id="37119759"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000159">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000172">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF174">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="627"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1358"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1408"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1442"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1471"/>
            <end position="1490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1510"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="317"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="19">
        <location>
            <begin position="1294"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="744"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="941"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1002"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="766"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="951"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1024"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="698"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="839"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="887"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="910"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1615"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PWY87216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1669" mass="187139" checksum="4EC757B57F4B0D43" modified="2018-10-10" version="1">MSRPDDVSESNHGQESTSEEQHTTEEGSSFPQTLPRSQSLNIHSAQEGAAPIRPSLSPSRTLSDAGRRPSQHHVRFSTDLERPSAEEVAGPDGNQRPGSRGLTINTNIAQLQVPASGRSPGQGATSPLSPHSALSPSSPQSPESVGRSRSRHRGYSLRRTIFAKNIESAVTSPGAIELGPAQGVSPQREEPVAEPLVEVPVRKSADVPRQSTEDEKQDALVTQRSASDSNLDISTTYYSEPSENLKDRKHLSTSISYEKWLQRRAAIATLKLRLEDMLETARKTILRIKEIPPSKDGRHIDLDATRTEDLVDERTGTLYVGNSIRSSRYSFWSFFPRQLFAQFTKLANFYFLIVAVLQMIPGLSTTGSYTTLVPLLIFVAISMGKEGFDDWRRYRLDKEENNRYAFVLRPGAGMFTQMAPSDSLSVSSEQDWAPVKWKDIKVGDVIRLERDQPVPADMVLLHADGPNGVAYIETMALDGETNLKNKQPSQPVAKVCGSVEGICSNALHFAVEDPNMDLYKFDGNVTIAEDEKLPLTNNEIVYRGSILRNTECAYGMVIYTGEECKIRMNANKNPRIKSPSLQAKVNRVVMLIVLLVVILAVSCTLAYKFWFHQQVEPNSWYLTQASVAIGPIFTSFLIMFNTMIPISLYVSMEIVKVAQMLLMNSDIDMYDPETDTPIEARTSTINEELGQVSYIFSDKTGTLTNNSMRFRKMSVAGTAWYHDFDLVEEAAKAGDQTKLIHKKRNVKGKKALSRKSNVSEARRQPPRTSMSMTNELQGRGASMRNNRTTDMLKYIQRKPYTVFARKAKMFILALALCHTCIPEDDEAGNVTFQAASPDELALVMAAQELGYIVRDRQPNTLTIRTYPNGPDDTPCDEVYEIMDVIEFSSARKRMSVVVRMPDQRICVFCKGADSILMRLLKRAALAQERAVEIERRASKRKAAEAAQVVRRNSEYHSRKDSGLRTSFARPSMTRRRSSVTGDHVSALRESIDVWLRDRETDGGMLTRGDDPEYYSPRPSAQLGRPSSTWSDSGSSVHENEEEDLVEEALVVNETAVFERCFQHLNDFATEGLRTLLYGHRFLDDATYNSWKAAYREASTSLVDRQEKIEQVGEQIEQQLELTGATAIEDKLQHGVPEAIDKLRRANIKMWMLTGDKRETAINIGHSCRLVKDYSTLVILDQETGEVEQSIVKLTADIIQGTVAHSVVVVDGQTLSMIESDEILEAQFFRLAVLVDSVICCRASPKQKAFLVKSIRRQVKGSVTLAIGDGANDIAMIQEAHVGIGITGKEGLQAARISDYSIAQFRFLLKLLLVHGRWNYIRACKYTLGTFWKEMLFYLTQALYQRWNGYTGTSLYESWSLSMFNTLFTSLAVIFLGIFTKDLSASTLLAVPELYTKGQRHGGFNIRLYLGWTFMAACEAVMIYFCMFGLFENVMFTHTGSDIFSAGLLSFTACVIVINTKLQVLEVHNKTYLCLIVWVISVGGWFLWNLILDARYNPSSGDGIYHVLGNFIFASGHDLAFWAALFVTIVSVIVFEMTVNAVRALLFPTDVDVFQEYEQDLDIRKRFEEAAASELQQGWDHGKKKSSFELAREEEMEARELQIRELLARPRVMTTNPKAAGPIKTEDVELGGYRANSMPEEEVPKTPRRSVEVHELFSKGFGAIRKGHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMD3</accession>
    <name>A0A317WMD3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHH phosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_441335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467023.1">
        <property type="nucleotide sequence ID" value="XM_025607508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMD3"/>
    <dbReference type="STRING" id="1450535.A0A317WMD3"/>
    <dbReference type="GeneID" id="37109651"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="285"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY86432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="461" mass="51120" checksum="967344F72C0C1555" modified="2018-10-10" version="1" fragment="single">PVEHSLFQFLAKALQTHHRFLAGRLSRAEAPIYVIGNPSADLDSIISAIVYASFAHPRPHVPLINLPSVRAGPELRRLRPEFVKSLWLSTHPPAPDDQTWADTPESAGSLLHDHLLTVADFVSHLEQLPNSPDTLISADAVLVDWNALPIRSPDHPRGQGSLSSLPNITFTVVGCIDHHVNEDFLGPITDPDQPFLLQPSGSCTSLVVNMLDKMDRWRRTTPAPSPAEHQLAKLAMSPILIDTSNFTAKEKVTDSDTLAYSFLRSKINSIPYGDTEKPWDHNSFYEEINTAKRNSLDLLTVEEVLDRDYKQWTESPGSNSQEEKVEIGICSMVRSLPWVVRKAETAEAFLHALGEFAKQKELQIVMVVTAFTTGSEGRFCRELLVCAKEGTGVRGVEAFIERAGAELGLEEWKVLDGEEGGELGDAECEDKTMRKWIWVQGNVTKSRKQVAPLIREAVGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMS6</accession>
    <name>A0A317WMS6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="16">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_535522</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Microsome membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SFH5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466948.1">
        <property type="nucleotide sequence ID" value="XM_025611803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMS6"/>
    <dbReference type="STRING" id="1450535.A0A317WMS6"/>
    <dbReference type="GeneID" id="37113946"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000017">
        <property type="entry name" value="Phosphatidylinositol transfer protein sfh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="18">
        <location>
            <begin position="204"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="400"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="8"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="78"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY86357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="455" mass="49886" checksum="AB1C6388B997257D" modified="2018-10-10" version="1">MADQPEKTTAPVAAPEAQPPTTTTVPVPEPAVSELQPQPEQKVEEQTIAEASTAPAAAPAPTDPPATEPAPAPAQEATEDKKDETEEHKEEQAEESQDVKVEEPKEEPKEEPKEEPKEEKKEEEKPAQPEYLAMNPALSQFFDRLPAILSSTGYSEMWGVSLKDSSDVPTVNVLIKFLRANEGNVKLAEEQLTKALRWRKGMNPVALADGHYSAERFGGLGYVTKYPEASGKEVIVTWNIYGSVKSVDATFGDVDEFIKWRVALMELAIKDLKLSEATTVIDYDGEDPYQMLQVHDYLNVSFLRLNPTIKAATKKTIEVFSTAYPELLREKFFVNVPAIMGWMFAAMKVFLSKNTTRKFHPISNGANLAREFPSLKDKFPKTYGGNGPTLQEESLTVNLDKAEPAPEPAAETPAAPAATESQPAAEAPKEEPRAEEPVKADAAVTAQETPVVEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMT1</accession>
    <name>A0A317WMT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Acetolactate synthase</fullName>
            <ecNumber evidence="4 12">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_556313</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 pyruvate + H(+) = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 12"/>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467609.1">
        <property type="nucleotide sequence ID" value="XM_025613856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMT1"/>
    <dbReference type="STRING" id="1450535.A0A317WMT1"/>
    <dbReference type="GeneID" id="37115999"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000008">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000053">
        <property type="entry name" value="Acetolactate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="16">
        <location>
            <begin position="97"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="14">
        <location>
            <begin position="295"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="15">
        <location>
            <begin position="503"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY87826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="695" mass="76147" checksum="E889334E25B5020E" modified="2018-10-10" version="1">MMPMRPTQGALRTLHYQRYLASGRRTFTTSSVAATASPHRFAAQKRSQSTATAPASNSRPVPSPAFNQEPHRNEVSPLQNRQVPELDDSTNSFVGLSGGEIFHEMMLRLGVKHVFGYPGGAILPVFDAIYNSKHFEFVLPRHEQGAGHMAEGYARASGKPGVVLVTSGPGATNVITPMQDALSDGTPMVVFCGQVPTSLIGTDSFQEADVIGISRACTKWNVMVKSVAELPRRIQEAFEIATSGRPGPVLVDLPKDITAGILRKPIPMNSTLPSLPSAATMAAREVSMQQLKGSINRVARLVNMSKKPILYVGQGLLARPDGPQILKELADKACIPVTTTLQGLGGFDELDSKALHMLGMHGSAYANMAMQEADLIIAIGARFDDRVTGNISKFAPQAKLAASENRGGIVHFEIMPKNINKVVQANEAVEGDCAENIRLLLPQLETVPERKEWFEQINDWKARFPFSLYEKQTAEGPIKPQALIEKLSDLTAHMKDRTVITTGVGQHQMWAAQHFRWRHPRTMITSGGLGTMGYGLPAAIGAKVARPEALVIDIDGDASFNMTLTELTTAAQFNIGVKVLLLNNEEQGMVTQWQNLFYEDRYSHTHQKNPDFVPMAQAMGVAADRCTKPSEVEEKLKWLIEHDGPALLEVFTDRKVPVLPMVPAGCALHEFLVYDEAKEQERKALMRKRKVPGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN43</accession>
    <name>A0A317WN43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secretory component protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_535249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467359.1">
        <property type="nucleotide sequence ID" value="XM_025611738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN43"/>
    <dbReference type="GeneID" id="37113881"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029187">
        <property type="entry name" value="Shr3_AAP_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="210" mass="23528" checksum="3B3311A732225B12" modified="2018-10-10" version="1">MAFRNGSFATFLIVCPTSFFLGLIFSLFPYDYPILWSPTPTPEDYFTYFETHLRFLHASPPLIPRILHIVIFLGLMGLILKLYKPSESNMLFDGASLVLYMCGITVYIANIVKGLRLVSAGRYGDELLELNKGDGVDVEEGQILGREDSLKVLAASNTILALVLVGVLVLQAGQWYAERKEAQEVESFRSREQAGEKEKEKVEGGKKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN61</accession>
    <name>A0A317WN61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Structure-specific endonuclease subunit slx1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_556901</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467019.1">
        <property type="nucleotide sequence ID" value="XM_025613899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN61"/>
    <dbReference type="STRING" id="1450535.A0A317WN61"/>
    <dbReference type="GeneID" id="37116042"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1440.10:FF:000006">
        <property type="entry name" value="Structure-specific endonuclease subunit SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GIY-YIG" evidence="11">
        <location>
            <begin position="14"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="341"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY86428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="424" mass="47694" checksum="D7EF17DFE909B53D" modified="2018-10-10" version="1">MDDAEVDHTKPIPAFYCCYLLRSTKQRTSLYIGSTPHPARRLAQHNGDSKGGARKTAKDDKRPWEMVLLVEGFTSRVAALQFEWAWQNPRMSSQHPANRHQLELGPGGETQATSGTQPSAETGKAKHRGRGSRRSLKAHIEDLHLFLRSTYFSKWPLKVRFFNADVYQLWITWCDRVDGLLPDHVRIILDGDCPNDHLPCKDDSRVQHVDQIKADYSNIHDYLEKSHFLLDDPTDLRCKVCQATIIPSEELAVVCPQTNCHCISHLLCLSTRFLDSAKEPDQLVPIDGNCPLCDNLIQWSTMMQELSLRNRGRNEVQTVLQKAKKSRGRTPGAIHVTSAADKGANAMGEPGSRAEWVESSTGGSSDSFDVNCRDDASLDENWTETLDFDIEPCILDHSRTHNTGTSRIEIVIDDSDCDEMEELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPB7</accession>
    <name>A0A317WPB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_565995</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467310.1">
        <property type="nucleotide sequence ID" value="XM_025614530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPB7"/>
    <dbReference type="STRING" id="1450535.A0A317WPB7"/>
    <dbReference type="GeneID" id="37116673"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY87102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="195" mass="21934" checksum="2E84B1FC8B941784" modified="2018-10-10" version="1">MKLLYLGILQNAQAPAVELCAERDLSSYSRFTKGSISEFMTMFSKTVAERTKQGQRQDIQEQDFTFHVYARTQGIAGVIISDNEYPSLAAHQILSKMLDEFVSLNPNAGSSRDPVPFPSLKTYIQAYQDPHQVDSILKIQKELDETKIVLHKTIESVLERGEKIDDLVSKSEGLSAQSKMFYTSAKKQNSCCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPK3</accession>
    <name>A0A317WPK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_585426</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467738.1">
        <property type="nucleotide sequence ID" value="XM_025615693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPK3"/>
    <dbReference type="GeneID" id="37117836"/>
    <dbReference type="OrthoDB" id="4493311at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016463759" evidence="2">
        <location>
            <begin position="18"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="396" mass="37384" checksum="09136F77D4346CED" modified="2018-10-10" version="1">MKFHNVAPLCLAGCALALPTPVEKREDLSDLFGFSLPSGLSLSSGLPSLSLPTDLSSLFNNRRDLPFSLPSGAALPTNSEGLSELLPSGFPDLSELGISLPTGLSSTKRQLGGGGPSGGSPFGGQSSGSSSLPSLGGGDSSQSGDSSSSSGGLPDFLGSLGGSSSSSEPSSGSSSGGLPDFLGALDGSSSDSSSSSAPSSGTSSGGLPDFLGSLGGSPSGSSSSAEPSSGSSSGGLPDFLGALGGSSSQSSSSSKPSSGGALGGVPDFLKPFLSGGSSSSDDSSSAAQPSGTLGGSSGSPPSLPSGSPFGGSSSSSSDDSSNPAQPSGSLPSISLPEPSSSSSSSEDSSDSEPSLTPPTPLAAFPGSPNIPAPSSSAVPTSSAVPKAVPTALSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPU0</accession>
    <name>A0A317WPU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4139 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_624327</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467335.1">
        <property type="nucleotide sequence ID" value="XM_025617211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPU0"/>
    <dbReference type="STRING" id="1450535.A0A317WPU0"/>
    <dbReference type="GeneID" id="37119354"/>
    <dbReference type="OrthoDB" id="10068793at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4140" evidence="3">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4139" evidence="2">
        <location>
            <begin position="288"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY87127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="758" mass="83174" checksum="A56E22921831EF94" modified="2018-10-10" version="1">MADISSTEIDLAELSTTAVTFHPSRATITREIPVAVQPGPNKITIHGLDRAVDIDSIRIVGSGPATVTDIQTEFVKRRDPLFSDSEDSSSDEDSSFSDEEDTVWTPDLESARANVASAEEEYLRAQCAQETAAAVIDFLDRQSTSFRVGWHGLNVGKLNGYLTICSTVRGEKAWEHAQAGIKMRKALEKKGMWVRKCERLEEKARKEKSRRLKEVSKERQRKVRERKELREKRERERAEKRRFWTRMVGQVVVHLDGQERVVSSRRGSMCEKPKIVDEEEEEKKGVVLRLTYVVPGLSWTPRYDLSINTPSSSAKLIYRAQFSNVSSETWRDAKVTLSTSQALFAGLGERIPSLQTWNLVVESTEKGKDQPSWDKILRSVPEEKALPSVKSNHQGLEQQPRPKPLFNQPLFQPEPVFGRPPTQCTQPSAFGQPTSSSLFGQAHNPSGQARGGIFGVSPQPSAPDSTGPPAVGASASPFARPVAGGLFGAPAQPPTLLASTGKLTPESGSESDDESVTVEELPVPSLEVQDSFKQDYGLTTTYELPGRRSLAPSSVPRRHVLAELDLDSVSLAYVIVPKHRAAAFLRAEIKNSSSVNILRGKVGMTIDGTFLGTTQVPSCSPNESFTLSLGVDPSIQVTYGKPIVKPVTGGFFNKETAAVFRRTCVVKNTRSNAVDVTVMDQVPVSEDERVGVQILEPKGLNVLGDEVTLPLEKEGKGTAKLGVNGEIKWVMKLEPGKEVRLVLEYEARVPVGSEVNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQB2</accession>
    <name>A0A317WQB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_624314</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467316.1">
        <property type="nucleotide sequence ID" value="XM_025617208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQB2"/>
    <dbReference type="STRING" id="1450535.A0A317WQB2"/>
    <dbReference type="GeneID" id="37119351"/>
    <dbReference type="OrthoDB" id="4492087at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY87108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="341" mass="37943" checksum="C23356BAFCF4DF0B" modified="2018-10-10" version="1">MLRAIHNPLTSRPIIIPSLHPPPIPITPITHQKKPITTHSHPKYNPQSLKPTLQKILSHFPTPIDYAIAYGSNIFPQSQSQSPHTSNIPKMTDLIISVPSTQTFHTHNLSTNPTHYPPLISTLGPTLISKLNDTLGAGISYTPYITINNTSLKYGIINTPSLIHDLLHWESMYLAGRFHKPILVIKDHEGVEEARKRNLESAVKVALLILPGTFTERMFYGVVVGLSYSGDVRIVLGGEGRGKVDGIDMCPRVRAELVRGLPRGLRRSVYARFSGGDEDEDGMARRVVLDPRSKEIVERAVVETVRWPSLVQSLKSIVTAGVGRSWRYAMEKRRKARGGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQS0</accession>
    <name>A0A317WQS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_585222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468216.1">
        <property type="nucleotide sequence ID" value="XM_025615678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQS0"/>
    <dbReference type="STRING" id="1450535.A0A317WQS0"/>
    <dbReference type="GeneID" id="37117821"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="2">
        <location>
            <begin position="82"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="271" mass="30428" checksum="7C779E329505D5D7" modified="2018-10-10" version="1">MSPPPTPSTTIPPHHVHPRHRINTTNYNNNNNNNQQQHVLKHVLKHNHNHTHTHTHQPPIHTTSTPTPTIPWTPTTPQTRPLAIIGAGCLGRRIACIFSAAGHTVHLRDPSAKARTEALEYITTHMPEYTDFPLIPRPQGPCHTFSDLDTCVQNAWLVIESVPERLPLKIEVMGELDAKTPSDCILASNSSSFKTSFMVEKVRSERRPLICNMHFAMPPRIRAVELMTNGETDLQVLSFLTWVLDDCGMMPVTARKERSGLVRSHCLNTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRQ7</accession>
    <name>A0A317WRQ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_546003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467600.1">
        <property type="nucleotide sequence ID" value="XM_025613275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRQ7"/>
    <dbReference type="STRING" id="1450535.A0A317WRQ7"/>
    <dbReference type="GeneID" id="37115418"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="266"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="403"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="833"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="537"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="706"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="735"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY87817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1184" mass="131183" checksum="10A8C858B733C26F" modified="2018-10-10" version="1">MSHHASTTLPAHTTNGEAHAPNDRAQVPLSDSKPMSVNRKKQKRRQKQAARLAAERELGNGHASAEITSPNGLSPTAPESHVSGDHDIDEVTPNGEIYYEEIHDATHVQDDPLELSNGQIGQQIPTSSKTKKKKGKKAHAGSQSHGDESSTPISTLSDLSQPIPPPLPPHLGPHTILKSSKDRSIWNTSTQEERENIKTFWLELGEEERRQLVKVEKDAVLKKMKEQQKHSCSCTVCGRKRTAIEEELEVLYDAYYEELEQYANNNQGSFEKGPPMIPPPRLYHPPLRSPGQHTRTQGQFHPSRGRIHELQEDEDDLDDDYDEDDEDDEPYSDEEYEDDDTRAARADFFAFGNSLTVKDGILTVADDLLKNDGKHFIDMMEQLAERRMQREEDTQYGIAAAHQSLHSGHNHGPLDDEDYDDEEDEDYDSQEDEDYEEDEMVSSGNWPGGEAVQADTFLQDAMTEEQRMEEGRRMFQIFAARMFEQRVLTAYREKVAEQRQQKLIEELMEEQTRNEQRNAKKAREAQKRKDKKRLQKQAKEEEKARREAEKAAEEAAAKAEQEKKLEEQKKKREEQRKKREAERKAQEAERVRKEAEKQKRLREERERQAEIERRQREQKELEKKRREEARQKDERERKVKDEQTRRDRDTTPREPEVSKRVSHGPVPIPPNLHQHAQGLLAHFQSPHFQVATPVVPKAPTPARPRQPSQQGSRTSSPRSQPASTEPSQVSISPRSMAPSQSSGASSITSKQGHAQPPLLHHPQPSTPLSPLGALSRSHPPGFSPSNPPGLGLVSRPPIGHDLPSYPPHSGPLMNQLRGFPAPNGLPVLPGMNGTRPIPPGRGFPLDPGHGLSFHHQPIANVFSTQPSGLSHAHSRQPSSSFDRSPLEALPIARPSPIKRPSSTQQDQNNRPARRDVDDLSAHLGSSALLDDTDVPFTSNLSQSLPGATAPGSLPGPARASFAGTSLFTDPLGELLAKQSILTDADSSTAGKHSSFSIGNGIGNSTWGAQIPFGASPFPTAQPWGTGPGSGWSNNAFAPGGHHRAHASRPVTIRLLVIQACKQLNMMSPSKGASGYHDVKIVLRQVDQLRPSDEPPITLKEMLDICDTEGSTQNGGGSFLIRSDETGDYVKFEPDTNSASSGHRASIVPGEIGSPVPSSSLPAFGIGTSISTPSVLRQFSSPTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSB1</accession>
    <name>A0A317WSB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_465334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467810.1">
        <property type="nucleotide sequence ID" value="XM_025608109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSB1"/>
    <dbReference type="STRING" id="1450535.A0A317WSB1"/>
    <dbReference type="GeneID" id="37110252"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="100"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="383" mass="43221" checksum="913E8A381BD98EF1" modified="2018-10-10" version="1">MAPSLVEATPLSLRSAPNAALKTDAGFNKENLIGYGEAYKHDNELKGTEKQPPASFPNYLPVWDNETERYPPLQPFEHYDHGKDADPTFPDLLPKDKVEVDDITPTIGTELRGVQLSQLTKEGKDQLALYVAQRKVVAFRDQDFAHLPIDKALEFGGYFGRHHIHQTSGAPKGFPEIHLVHRGADDRSGAEFLATRTNTITWHSDVTFEKQPPGTTFLYILDGPTSGGDTLFADMAQAYRRLSPEFRKRLHGLKAVHSGVEQVNNSLNKGGIARREPITSEHPIVRTHPVTGEKALFVNPQFTRYIVGYKKEESDYLLKFLYDHIALSQDLQARVRWRPGTVVVWDNRVAIHSALFDWEDGQRRHHARITPQAEAPYETPFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSP1</accession>
    <name>A0A317WSP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_37807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468394.1">
        <property type="nucleotide sequence ID" value="XM_025607238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSP1"/>
    <dbReference type="STRING" id="1450535.A0A317WSP1"/>
    <dbReference type="GeneID" id="37109381"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="39"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY89483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="355" mass="40828" checksum="2B25195C5B2071E7" modified="2018-10-10" version="1">MRGKVAIEEAFELKDATGEIEAQAALYIAPNDVERYKRQIVSITDERLELSEKNGIGYTILSLTVPGIQGITDQSEAEKRAEKVNNYIHDQIKGHRDRLGAFAALSMHDPRQAGQELRRCVKELGFHGALLNDVQHTGKGDADQPLFYDGSDYDEFWRVAVELDVPVYLHPAAPLRDTINYKQNYADRKYLVGPPQSYCNGVALHLMGLITNGVFDRFPNLKVVVGHMGERIPFDFWRMNHWVNGVERPLAQKNGDTICEREPLYYFQRNIYITTSGHFCTQNLRYLYEYLGDERLIFSVDFPYERMEHGCSWYDDDEEQIKEALGGRDGYLRVGRDNARRLFKLSKFKDCDAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSP8</accession>
    <name>A0A317WSP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_585142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468133.1">
        <property type="nucleotide sequence ID" value="XM_025615674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSP8"/>
    <dbReference type="GeneID" id="37117817"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY88771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="93" mass="10717" checksum="C7C5EB96CAD22A25" modified="2018-10-10" version="1">MGYTTLKRTMDWYFVPLDLAAGDVTNPSIEDANGIVMQVVYCERRPITNRSPKSRRTNVFSQLAGGLSLPQQVRRTWDAQYWMIEAWLVASYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSQ4</accession>
    <name>A0A317WSQ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMMECR1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_58884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467711.1">
        <property type="nucleotide sequence ID" value="XM_025615910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSQ4"/>
    <dbReference type="STRING" id="1450535.A0A317WSQ4"/>
    <dbReference type="GeneID" id="37118053"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="90"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="325" mass="35931" checksum="3D5626573F873978" modified="2018-10-10" version="1">MATPAQCYYCFETLAASYRRNEPISLASVEELWERHEQYKKLAALDDDGDSQSVDDDEVTGGPAGNSSRSQKIKVPRVSRLQSGSSSSTTPSITSANSSQSILSSSTTVTTPSSLSTQSDTASRKPREEKYPLFVTWNTISKHGHKSLRGCIGTFEAQELAEGLKSYALTSAFDDTRFSPIPESLLPSLSCSLTLLGSFEPCTNAMDWILGVHGLRISFIHRGRRYGATYLPDVAVEQGWTKEETVISLMHKAGWDGPTESMARRFLRGSNSNSTSHGATKPWEQVSDFRAVKYQGLKASSSYADWQDWRQWVLSLDDRSEQLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSX2</accession>
    <name>A0A317WSX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_75349</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467538.1">
        <property type="nucleotide sequence ID" value="XM_025617648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSX2"/>
    <dbReference type="STRING" id="1450535.A0A317WSX2"/>
    <dbReference type="GeneID" id="37119791"/>
    <dbReference type="OrthoDB" id="5951731at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006586">
        <property type="entry name" value="ADAM_Cys-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905">
        <property type="entry name" value="ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11905:SF159">
        <property type="entry name" value="ADAM METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13688">
        <property type="entry name" value="Reprolysin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00608">
        <property type="entry name" value="ACR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016385673" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="13">
        <location>
            <begin position="25"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="15">
        <location>
            <begin position="275"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="14">
        <location>
            <begin position="512"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="739"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="751"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY87330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="787" mass="83858" checksum="A2802D3D9AD06D89" modified="2018-10-10" version="1">MRFLTYSIPLVASAISLLGVNVQARSQSPSAIRHVSTLDHTTIKTPSQQVDHLSNFDIIFNLHDNDQRIKLELEPNHDILAEDAYVQYLDADGNVRREEPIARHEHKVFKGRSLLGRGKSMWDPVGWTRIYLKNDGPDPLFEGVFSVNGDNHHVELKSTYLEKKRDEDVDIVNTPTDYMVFYRDSDMVRRHTELKRSSLGSTSCQADKLGFNTDPNHPVLQSFGQEDTSAWGGMSLTSMFGLSRRQSDIGNVTGNAGGVNLQSTIGDTSGCPNTKQVALIGVATDCSFTGSFGNETAAKESVISIVNSASSVYEKAFNITIGLRNLTITDSSCPDNPPAATAWNMPCSSGNLTSRLDLFSKWRGDQTDDNAYWTLMSNCATGNEVGLAWLGQLCNSDASSDGSSTVSGTNVVVRSSGASWQIFAHESGHTFGAVHDCDSQTCAQDLEATSQCCPLTTSTCDADGKYIMNPTTGTDITAFSKCTIGNICSALGGNSVKSSCLSANRDVTTYTGSQCGNGIVESGEDCDCGGEESCGDNKCCDATTCKFKSGAVCDDSNDSCCSSCQYSSAGTVCRASRGDCDEAETCSGNSSTCPTDAFKKDGTSCGSSGAGLTCASGQCTSRDYQCRSVMGTLLHSNDTYACSAFSSSCELICTSPKIGECYSVNQNFLDGTPCGDGGSCSNGDCKGQNVESWIKNHKGIVIGVACAVGVLILLALCSCILGRCRRARAPKPMPRPAYGGWTGPMPPPPQMNQWPARGYYGVGNEPPPPYPGPTGQPVQYTPPGRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTV7</accession>
    <name>A0A317WTV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family helicase/ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_534297</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468436.1">
        <property type="nucleotide sequence ID" value="XM_025611511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTV7"/>
    <dbReference type="STRING" id="1450535.A0A317WTV7"/>
    <dbReference type="GeneID" id="37113654"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="464"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="924"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY89525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1097" mass="121923" checksum="6C6F95DE32BF5531" modified="2018-10-10" version="1">MASHAAMLLDPRAYKKRLQQKNKNNGTAQEPSTPQRGGVAVLSPRRRQPSQRGSPKSNSRSLSRSTRSSIARDTASSSPQHEASTEPVVEVEFTNAHLEDERSDGKRGSEQMDDARHGSLIENQPYKRIKVDGDQDLRSRARRFPVGNTGLGKWVKEGRSQSDSPAVVPNVVDLTTDASAATTDDDDVQVTGSNNLSLQRVCYGKIENATIQAQLVPKPSSQTMFSGSTHDWPSMKLGVHRQPGQNNRIEVSDPNGKVFGLVDAKTASVIVPLLDSPALTVNITARLDVRRRKDGEWPWAPCSSIYRASVNLYGLRKDAVGVGKHLGQHNVWLGTPFSVELGVPVCNPHAERRRIPPALGPAGAARSRVGVNYEVRTAEEVNDAVMKMFDQLQSADNLPEMDPPPSLSTPLLRHQKQALWFMTEKEKPRKFGPEEADNNSLWRVDYRANGKKRYREVISGTVLDEEPPQSLGGLLADMMGLGKTLSILSLVLSSLEEASQWTGLIPDPDMVRSLPGIRNTKTTLLVAPLSAVNNWVAQIKEHLQADALSYYVFHGSSRTNDVDELSKYDLVITTYSIVLSELSGRGAKRGVSPLTKMNMFRIVLDEAHTIREQSAAQTQAIFKLNSQRRWSVTGTPIQNRLEDLLSVTKFLGLFPYDDRGRFGIHILSRFKTGDATVLASLRVLVDSFTLRRVKDKIDLPARHDKIIMLTFTEKEQQLHEFFRKESNVMMRVIAGEEQTKMKGRMYHHILKAMMILRQISAHGKELLEPDDRKRIKGMSVHDAIDLEEGAGDTTGATDKKAYEMFTLMQESSADTCAVCGKRLEEPSSDNGPTDRRTAMAIVLPCFDVQCPDCFSDWKDAFDNPGPAHDIKCQVCDGWIPASYSMITVGGLQDYMMDQAQAKQSRRHGKTLGEYGGPHTKTKALMAQLLESAEESQGQDRPIKSVVFSAWTSHLDLIEIALRHNGITGFTRLDGTMTLAARHKALEEFQYNDGITVLLATIGAGGVGLNLTSASKVYIMEPQYNPAAVAQAVDRVHRIGQQREVTTVQFLMKGSIEEKIFELAKKKQQLADLSLNRGKLDKKDVQEQRMREYRGLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWC9</accession>
    <name>A0A317WWC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_574665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467982.1">
        <property type="nucleotide sequence ID" value="XM_025615033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWC9"/>
    <dbReference type="STRING" id="1450535.A0A317WWC9"/>
    <dbReference type="GeneID" id="37117176"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016468399" description="FAS1 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="106"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="251"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY88620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="501" mass="55914" checksum="8EC80D03073B9F4E" modified="2018-10-10" version="1">MKLPLWPLVALPLSAALHHPQVPLQDATNDVDIDIDIEPDLDNLDLDSLTTSLACALHHSTTDTWSSYIDDLDSTETSTLPQSLSQLPPPFRHPSPPPFHRHPPSNKSLYDLILSDPDTTILAKFISHDQDLTDLLNTTSSNLTFFAPTDDAIRRIHHHYLLHPHHPNLPHHQQHLLPRRPLPHPHPPHNPNLRASHPPNTPSTNSLPQRLTIHPTWKGLTLNFYAHITSLDHRASNGNLYHIDSVLLPPLPSLTLLNLVPTEFSTFVLALYKTGLDGWLNLTTTTTATHFSSSSDPQEKGDEEEKGGLTLFIPNNVAFEHTFSKLTSAWLFNSPRGLKYLAALVKYHIVPRETLYSDTLYRRDGEVVGFGLKGLVRVTLKSLLSGEHCDEGGDGEGDGNGDVIVDVGRFGPYASLRVNGFQRVKVADLVAEEGNGHVLDRVLVPPRRVEGRVVDEGKEEEMEGEIGMEELKRRLVGFVDEEDEDEDEFDYDYMGEGSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYA6</accession>
    <name>A0A317WYA6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exosome complex subunit Rrp46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_462845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469081.1">
        <property type="nucleotide sequence ID" value="XM_025607991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYA6"/>
    <dbReference type="STRING" id="1450535.A0A317WYA6"/>
    <dbReference type="GeneID" id="37110134"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000036">
        <property type="entry name" value="Exosome complex subunit Rrp46, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY91353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26164" checksum="4B9DF1928E8E370C" modified="2018-10-10" version="1">MVGPTATLTPLARADGSASYQCPSTGSNILGSVNAPVELPGRRDALKPEEATVEVFVKPGTAPAGVSERYVEGIIKGVLGRLILGRERGYPRRGVVVTLATVGGESVGRGESYLTLLPALLHTALLALLSASVPLSMTFSATVLAVSDLGDIIREPSTEQAAAAKSVHVLAISSKGHLLLNESQGAFDFETWEKVHERALAICHGTSAIGTDGDIAMVEDVDGQPLEGTIRETIDDQVHRDYAWKIDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ75</accession>
    <name>A0A317WZ75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4232 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_544404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469407.1">
        <property type="nucleotide sequence ID" value="XM_025613176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ75"/>
    <dbReference type="GeneID" id="37115319"/>
    <dbReference type="OrthoDB" id="21416at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25052" checksum="CC7FDD8230646FB9" modified="2018-10-10" version="1">MLKVLVLSEPLHALRTYLRVADNVWALLWYAAPFRPVAEDVSWTRLPVPSDLRDNGMQMLRHGAGSTTDAECLDDCRPKTMTSADKSDGFASTVVTIRNANPGTCSVGGQVWSAITIDGQKMVRQMTPRTHYYGGERFHTVPRRACQPRGMASAHRVPGRLRRLQPHQAAASQSPTPIQQVLNTPSVLSVRLENRELNGNIALFVQYRLDRAEFPPPSVQEKPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZE9</accession>
    <name>A0A317WZE9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ORC6 first cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_564497</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469477.1">
        <property type="nucleotide sequence ID" value="XM_025614422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZE9"/>
    <dbReference type="STRING" id="1450535.A0A317WZE9"/>
    <dbReference type="GeneID" id="37116565"/>
    <dbReference type="OrthoDB" id="5367324at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008721">
        <property type="entry name" value="ORC6_cyclin_first"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05460">
        <property type="entry name" value="ORC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ORC6 first cyclin-like" evidence="7">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY91749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="447" mass="49401" checksum="F09B395591983CD9" modified="2018-10-10" version="1">MNKRPVEQALGILLPTHAQDLPQELLSLALSLVAQSRSFSSSLKPEEEIARPYACAEIACKRLTRALKLPPLLGHPPCPPRAYKKLYAFLDRSLSTSLTSASRTGTTSAPGTPSRTGSAPSTPRKGQKTPSKITATPRGFQTNTPTKSTSLKRALTHDTDKPSPSPRPQKITKLRQNGVSGSTIIPDAPAWVMTSIRTVCKTLSTPAPRMSTWSRPPISRTLPPHIFAGVSTTLYLISETTAKHEEEIDEEMMEFLEPVITTKDKDKDEDFKELINALIVAVYFIVLARRRQPADDAPETETKKMDKKTFSEMRQTALVSLGLPSTERRHREDVDQWIALVMEQSWAQRREWFENIPLAGELDGDEGDLSDQAGGFAEGEDGGRAAVAGRGSLVVGKSSRRGLLPGLGTMMQDRVDWLSEDRREDYVEWKAEMMARIELVERSAQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0Y2</accession>
    <name>A0A317X0Y2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_513126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469683.1">
        <property type="nucleotide sequence ID" value="XM_025609832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0Y2"/>
    <dbReference type="GeneID" id="37111975"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="108" mass="12720" checksum="861545404ED05AE7" modified="2018-10-10" version="1">MYHPKESSHFPVPRKAPVPKRTRPLSHKQQQMHLRRLFEKQVQQEQHPHLPTHQRPPPSNQDHPPQAEKSLYCDTTPIIINNPYKPSLISFPPLESITPQTQQRLYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X192</accession>
    <name>A0A317X192_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_533807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468678.1">
        <property type="nucleotide sequence ID" value="XM_025611399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X192"/>
    <dbReference type="GeneID" id="37113542"/>
    <dbReference type="OrthoDB" id="4153865at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY90300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6280" checksum="5D25942E551D1205" modified="2018-10-10" version="1">MTMQQPSSPEVPTTDRVVTEQPNYQEEMKMNLRGGGAGDVCCGVCAGLLCFECCEECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2U4</accession>
    <name>A0A317X2U4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <ecNumber evidence="3">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_533383</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>oxaloacetate + ATP = phosphoenolpyruvate + ADP + CO2</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469670.1">
        <property type="nucleotide sequence ID" value="XM_025611316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2U4"/>
    <dbReference type="STRING" id="1450535.A0A317X2U4"/>
    <dbReference type="GeneID" id="37113459"/>
    <dbReference type="OrthoDB" id="184182at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.8.10:FF:000001">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.449.10:FF:000002">
        <property type="entry name" value="Phosphoenolpyruvate carboxykinase [ATP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.8.10">
        <property type="entry name" value="Phosphoenolpyruvate Carboxykinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006820">
        <property type="entry name" value="PRK09344.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006821">
        <property type="entry name" value="PRK09344.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYKINASE ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="PEP carboxykinase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53795">
        <property type="entry name" value="PEP carboxykinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY91942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="600" mass="66446" checksum="527A1C4053F32D4D" modified="2018-10-10" version="1">MSPATNIHIPPVSPVETGPLYSDFFQQQVAKQRNNNYHSTSLRNMVAASVNRTALHPGGVLPGKGHTELEEELHEHAHIDYDRVAIIANPAVPALYEDALVYETGTAITSSGALTAYSGAKTGRSPSDKRIVEEESSKDDIWWGPVNKPMTPDVWRINRERAVDYLNTRNRIYVIDGFAGWDERYRLSVRVVCARAYHALFMRNMLIRPSQEELKHFHPDYVIYNAGSFPANRFTEGMTSATSVAINFAEKEMVILGTEYAGEMKKGVFTVLFYEMPVKHNVLTLHSSANEGENGDVTVFFGLSGTGKTTLSADPKRALIGDDEHCWTDRGVFNIEGGCYAKCIGLSAEKEPDIFNAIRFGSVLENVVFDPISRVVNYDDCTLTENTRCAYPIEYIDNAKIPCLSDKHPTNIILLTCDARGVLPPISKLTTEQTMFHFISGYTSKMAGTEDGVTEPQATFSSCFAQPFLALHPMRYARMLADKISQHKANAWLLNTGWVGAGATTGGKRCPLKYTRAILDAIHNGSLSQAEYETYDVFNLHVPTSCPGVPAELLNPKNSWTASTSFKDEVNKLARLFNENFSKYADQATKEVIAAGPVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3D1</accession>
    <name>A0A317X3D1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_618297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469216.1">
        <property type="nucleotide sequence ID" value="XM_025616844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3D1"/>
    <dbReference type="GeneID" id="37118987"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="292" mass="31052" checksum="A8AFEEC99CAD381B" modified="2018-10-10" version="1">MSCFRALLPIVGSCVAFLLGILCLFAGSQRQILPQADLLTLYTGGAGGAGAPDYFSVYTMSYCTGFQETVVSDETTNSTTTTNEIIGCSDRSVLFTFNPSDAILKALGTPSGSLSPDSWPSCITDDFEALGPTNTTMVVFFIFGTATAALAIGARIWSIACARASENSRPPSYTGDPSPRFDSESPPSLVEFVIFLHPSDISILQVSLLSFGIASVIASVITTEFVKLINKSGNDYGVSATTGTSFLGMSWTAAVLQALCTTYILIEILRYHARCRMPRSESAEEKPLVGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3G1</accession>
    <name>A0A317X3G1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_583399</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469920.1">
        <property type="nucleotide sequence ID" value="XM_025615561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3G1"/>
    <dbReference type="STRING" id="1450535.A0A317X3G1"/>
    <dbReference type="GeneID" id="37117704"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="266" mass="27907" checksum="3C6B4F66A8744CBF" modified="2018-10-10" version="1">MSSLTTSHAGKTYILTGGCSGIGLAILNILLSQSATVHVLDISSTPPQISAHLPQKNVHFYPNTDVSSRPSVHNAFTKILTITPTIDGLINNAGIASLPPVSGMESDESFDRTMEVNVRGVWNTGTEYLSRILPTPDPSSPDTDDTGPTEGKGVIVNIASTAAIQASIGFVSYTVSKHAVLGMTRAWAANFAHRGVRVNCVAPGGTDTPLVSGILDEKGKESYISRVPMGRLARPEEIANAVGFLLGGESSFMTGQVVVVDGGRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3I9</accession>
    <name>A0A317X3I9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_544170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469887.1">
        <property type="nucleotide sequence ID" value="XM_025613169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3I9"/>
    <dbReference type="STRING" id="1450535.A0A317X3I9"/>
    <dbReference type="GeneID" id="37115312"/>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="920"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6987" evidence="3">
        <location>
            <begin position="773"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="982" mass="104746" checksum="BEC6A2A732FDED95" modified="2018-10-10" version="1">MATTNQPVKQPSSLGRGEVTKEAPVRKQAPPELPKTVGQKGQAGQPALDEGGAKLQTKTVDEGQSGQFEGVDMWEVENLDQQRQVPEQRQAMPPETATGSASSHKQSFVDRSKAAAGRLGRFAKGAQSVKDHIPQGITEQTSHEIGDQEVGDRADGLGESRGGVGLDDTVPKPNSSDIKNIAKTVGDLKGLSVDETGKIVTSTGQPVGKVIEGDPKDLIGQIVGEGGEILDEDGDLIGRVDVLADDELEPVMEDGIPSQPLLPDISTLEGLQCTKFGSILNAQGTLVGELVEGDAKRLFRGGFEMDDKGQFWDHRGNIIGKAWPVPPDVDEISPFEGVKDLHVGQDGWVLDEDGRRVGQVVKGEAKKLEGRAVDEDGDILDRRGNRLGRAEPWQEPDEPEKVEEVEEKPNLSCLSGLKATKLGLVIGPDQVPMGKVIEGDPRHLAGKTVAPDGQIWGDQGEVIGRVELIPENERKDLMRPFQGEMDLMVNGSGWVEDDEGKVVGRVVEGDPKALQGYEVDEDGEIVDQHGTVLGRAERCEPPAETVEEPDLSVLGGKLVNKMGNVVDADGVVIGRLVTGNPRKLAGKSVDDQGQVWDSSGHVVGQAEVLPDAERDRPEGPFCGLDGLTLDKEGMVVNPSGTPVGRLVQGDVQRLAGRAVDEDGEVLDGSGNVIGRAEPWASPEEPASPMTGHKVNREGEVRDEGGNLIGKVTEGDLSNLVGRTVDKDGYVMDSAGNKIGQCTLLDNLPPEPMSEPEPEPEPELEPEISPEELEQQARQAEENELAKKMCSIVQQTLDSVEPICRLITQHIERANGAPKEDLDEEELVKQVKPLIEEAGYALQECKGALRALDPDGHITANAKAHSASQEATPQEHHLAELLKNLTKLVTETIERGKSLIADMPHAKKELNPLWALLSEPLFQIIAAVGLLLSGVLGLVSNLLDGLGLGGLLRGLLGGLGVDKLLEGLGLGTITQGLGLGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4K8</accession>
    <name>A0A317X4K8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_512980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469616.1">
        <property type="nucleotide sequence ID" value="XM_025609827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4K8"/>
    <dbReference type="STRING" id="1450535.A0A317X4K8"/>
    <dbReference type="GeneID" id="37111970"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="171"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="413"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="481"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="418"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="505"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY91888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="555" mass="61188" checksum="B0012226AF3C0165" modified="2018-10-10" version="1">MPPRGTRKAASTAVATEPPHSPEAGANKRKPDETQEQSSPLRRSKRAKPVATQSPSDKSTTRTAPTRSAAESPKATPRKPREGKVVSVKKELEEEEEVFVEAEVVDKGVAKEEEVDEKPMVKAKATRKRKIKEEVEMVPLRVRTQGLRMCVGAHVSAAKGVFNAIHNSTHIGGNAFALFLKSQRKWDNPPLQDDHRDQFRSLCTEHKYDAAQHILPHGSYLVNLAQEDKAKAKQAYDAFLDDLRRCEALGINLYNFHPGSANQSSLPDALTRLATALTNALRATTTVIPVLETMCGHGTTIGGYLHEFRDIIAQIPKEYHHRIGICIDTCHSFAAGYDLVNPAGFKAFMQEFDDTIGLQHLRALHLNDSKAPQGSKRDLHANIGTGFLGLRAFHNVMNEPRFQNLPMILETPIDRPESSISTTTSSSPKKKPTKKPTSTPTSAKLIADPSVWANEIALLESLIGMDPEGEEFRALEAKLSEEGREMREKQQEQYERKLATEEKKKTKAPVKKKGQKTLMEMMNGAGKTKKGKAAKGDESGGEGSDDEGCQSHAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4W9</accession>
    <name>A0A317X4W9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_340602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470136.1">
        <property type="nucleotide sequence ID" value="XM_025607035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4W9"/>
    <dbReference type="GeneID" id="37109178"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="80" mass="9282" checksum="F87DDD4CF424EA6E" modified="2018-10-10" version="1">MTIPKMRHRPNTLDRCLPNHHPLTTYPCSLYLSLLSLSIPALSIYPGLKNLDHIISMDEQGYRLCPRMCGYQLSLVYHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5B0</accession>
    <name>A0A317X5B0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione S-transferase UstS-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_614436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470152.1">
        <property type="nucleotide sequence ID" value="XM_025616736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5B0"/>
    <dbReference type="STRING" id="1450535.A0A317X5B0"/>
    <dbReference type="GeneID" id="37118879"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="90" mass="10251" checksum="177AE551C3877343" modified="2018-10-10" version="1">MEFLCLFVHGLPFNPVTAEKSKAEFVRRAGKKCWEELTVRGEEPVYADLVVGGWLKCFEVALKEWEVVRVWHGGLWGMLVAGLERFAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6C1</accession>
    <name>A0A317X6C1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">pectin lyase</fullName>
            <ecNumber evidence="12">4.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_458477</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Pectinolytic enzymes consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan methyl ester to give oligosaccharides with 4-deoxy-6-O-methyl-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.10" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470870.1">
        <property type="nucleotide sequence ID" value="XM_025607795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6C1"/>
    <dbReference type="STRING" id="1450535.A0A317X6C1"/>
    <dbReference type="GeneID" id="37109938"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047490">
        <property type="term" value="F:pectin lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000003">
        <property type="entry name" value="Pectin lyase F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF16">
        <property type="entry name" value="PECTIN LYASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016334750" description="pectin lyase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="15">
        <location>
            <begin position="95"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00036818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00039082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY94109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="379" mass="39742" checksum="C8F8AF87C59EA28B" modified="2018-10-10" version="1">MKYATIFSAAAAVFAGSAAAVGVSGSAEGFAKGVTGGGSATPVYPDTIDELVSYLGDDEARVIVLTKTFDFTDSEGTTTGTGCAPWGTASACQVAIDQDDWCENYEPDAPSVSVEYYNAGTLGITVGSNKSLIGEGSSGAIKGKGLRIVSGAENIIIQNIAVTDINAKYVWGGDAITLDDCDLVWIDHVTTARIGRQHYVLGTSADNRVTLSNNYIDGLSDWSATCDGYHYWAIYLDGDSDLVTMKGNYIYHTSGRSPKIQTNTLLHAVNNYWYDNSGHAFEIGEGGYVLAEGNVFQNVDVVLETYEGEAFTVPSATAGEACSTYLGRDCVVNGFGSSGTFSEDNTSFLSDFEGKNIASASAYTSVASSVVANAGQGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6N7</accession>
    <name>A0A317X6N7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_563691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470994.1">
        <property type="nucleotide sequence ID" value="XM_025614369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6N7"/>
    <dbReference type="STRING" id="1450535.A0A317X6N7"/>
    <dbReference type="GeneID" id="37116512"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="44"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="217" mass="24644" checksum="56361E243E8F8EF7" modified="2018-10-10" version="1">MTPIHNLEDLTYSHPDTADYTLDDIPTLCPLDNGQLHDAPIYGLGTLEQLPLELLQIILVQLEIKALTDFRRVNRQARQIVNSVPQYNQIVQHAPISIRAILSIETGDWITCQHLHETLLTDTCEKCGSFGGYLYLITCRRVCFLCLSTRTTYRPLLKVTAAREFGLRREDFANLPQMRCLPGVYSPVKSTYRRRFTYVDHDAARQAGIKLHGSVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7A8</accession>
    <name>A0A317X7A8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_582820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470198.1">
        <property type="nucleotide sequence ID" value="XM_025615502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7A8"/>
    <dbReference type="STRING" id="1450535.A0A317X7A8"/>
    <dbReference type="GeneID" id="37117645"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF2">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016192682" description="Carboxylic ester hydrolase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="502" mass="54561" checksum="8A2694799DDDD1F4" modified="2018-10-10" version="1">MTKTFLITSILATLARAAIDYTWDAVSAITPSNVSLSFVQAIPENGTFVVPSGNTGWPTNPIHLPELCAVGATVPGDTQNGTFGFGPFLPVQWNGRTLTVGNGGLAGGVNWVDMGTGVKYGHAVLSTDNGHNSTSTDASWSYQNPAAQTNLGGRALHETVVYGKEITEAFYGTEPAYHYYQGCSTGGRQGFKEAEMFLDDFDGVIAGAPAWWTSHQQICPYTTPNSTLFFPSWLHGSEHFWSLNIDSGNPNIIGLGYIQYTLGLGATWNWRDYNSSIQTLSSTLNAGQADASDYNLTPFYRSGKKLIHYHGMSDGGIATGASYYLYKEIDRAMRSSGGELDEFYLFTDSGDGHCVDTATYVNAPYYIAGISMTNNGQYSVPGYQDPKHDVLLALMNWVENGTAPKAIIGTAYENFTTMEKITRQRPILLLSANSINLLFVPPSHPRPRNNPPTNAAETIYVEELPLGAIAARVVEFLVDQAKYKNVDVRKSARGGTRRLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X808</accession>
    <name>A0A317X808_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_511953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469799.1">
        <property type="nucleotide sequence ID" value="XM_025609787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X808"/>
    <dbReference type="GeneID" id="37111930"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="267" mass="28495" checksum="B7B7346D1D6CABCA" modified="2018-10-10" version="1">MSSYAITGASKGIGREFVRQLAANPSNTILAIVRNPESAEISSLASKYSNVHAIKGDVTDPTSILEAASAAAAITGGTLDVLIHNSNAVDMASMSLNPTQLPYDAQAIRDIFDASFSTAIYGGIWTTNAFLPLIEKGNQKKIVHISTGMADLDLIKKSGVSYAVAYSVAKSGMNVQVAKYAAELAPKGIKVVALSPGWVDTWEGEKPPMVVEGMKLMLKQFQEVKPDLEGQIQPEESVRKVLQVIDGLNAESSGLLLSHNGDRESWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8C6</accession>
    <name>A0A317X8C6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_508928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471222.1">
        <property type="nucleotide sequence ID" value="XM_025609684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8C6"/>
    <dbReference type="STRING" id="1450535.A0A317X8C6"/>
    <dbReference type="GeneID" id="37111827"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000282">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048492">
        <property type="entry name" value="Stu2_CTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21042">
        <property type="entry name" value="Stu2_CTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="280"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="745"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="810"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="831"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="899" mass="97376" checksum="3A581D066EE17842" modified="2018-10-10" version="1">MAEGEEDFSSLPLPDRFTHKNWKARKGGYEEAKALFEKTPDESDPVFTPFIQDPGLWKGAVADSNVAAQQDGLGAYCAFLKFGGVQACTRSRATTVFPICEKGLPSTRPAAKTNAIEALLLCVELDKADPVIEEIIPALSHKVPKVIAATLAGLKAIYHNFGCKIVDPKPVLKVLPKAFGHADKNVRAEAQNLTVELYRWLKEAIKPLFWGDLKPVQQQDLEKLFESVSQEGPPKQERFTRAQQDAMAAASAAPEGGDDEFEGGEEYAEEEEEAGVDAFDLAEPVDVMAKVPKDFNEQLSSSKWKERKEALDALHDVLNVPRIKDGPWDDVVRLLAKSMKDANIAVVTVAANCVDLLAKGLRSAFLKYRSTIMSPMLERLKEKKQSVADALGQALDAVFIATNLSECLEEILEFLKHKNPQVKQETLKFLIRCLRTTREVPAKPEVKSIAEAATKLLTESSEVNRAGGAEVLGTLMKIMGERAMNPFLEGLDDIRKTKIKEFFDTAEVKAKDRPKPIVAPPKPAPGKKVLGAKKPALGAKKLAPPPAEEPVAAPSPKPATRSIPSKLGGAPKPSGLSGPGGLKKKLGGPGGLASPQRRVISPPSEDQPPPPAAPKFGLARGLAGRPIAKPSAPSEPAPAPAAPQLSGISAIERAELDELRAEKERFMRMVEDLRSERTKLNSQVMELQDQNAQLIEDHTRDVLSIKAKETQLVRARSDAEAAEQSVQKQQREIERLKRELARALRASAMSPPNTLPENIGLPMSDAGSVYQDDGRGPMSRSSLLVGSRFESSRPRSYASASPSEEKENNGLESSGLSSREGGLGRRKLSPTFGTSYSGLGSPTRSSVLGSGSASGEDQPTRSAEPAESWKRAAEVTSQLKARIEQMKARQGLIRPPSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X965</accession>
    <name>A0A317X965_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_621861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470229.1">
        <property type="nucleotide sequence ID" value="XM_025617025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X965"/>
    <dbReference type="STRING" id="1450535.A0A317X965"/>
    <dbReference type="GeneID" id="37119168"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF13">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN MOC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="530" mass="59979" checksum="2805B6E666B9D024" modified="2018-10-10" version="1">MDPRGKALNNAPKRSRMLICKARTGCLTCKTRRVKCDEQKPVCNRCISAKRHCAGYQKPQDNHPKPFHITYYVSDLISSTGALHRPLEDLRDQRALESFYLWGKACFPDDLMEPFTHDDILREPALRHAMIAMGRLYEIYRDGAVRASNPELNVYAMQHYGKALRGLVLRNLETAGEPSPIFLIACFLFVCLETSQGHTEAALRHLQSGYKLFQEARRSGKLLKQCEPIFRWLFTRLMCQMTHFDPNDCARFFGLNGSQSKPLDTFTHLEDARTHLGNLMQKMIHRRYLATLIKVSPGPNKQVFVADQTKRLLAQELAELDTWILAFNHYLSFDISTHDTGDYYVLATCSFLLKFRLMAESRNIGKHDENGSLDFKHILDLGHTLLSDGHIAGSLSRSPTGSNCRPETDFHGNQMLETEVATSMALMQTNAPTDPHFLFLGIMSALSVASAHAPDQAVRQQAQQIVRTICESRMDRDSGLAVYLTSCLSHTRSPGCHDDRTLYGDFSVPEASYSQESRRLIELLGDFGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAA9</accession>
    <name>A0A317XAA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_582842</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470221.1">
        <property type="nucleotide sequence ID" value="XM_025615505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAA9"/>
    <dbReference type="STRING" id="1450535.A0A317XAA9"/>
    <dbReference type="GeneID" id="37117648"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="241"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="477"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="543" mass="59105" checksum="014099614E9BCEB8" modified="2018-10-10" version="1">MADAAVESGYQKGVLPDTKAVEEGPRRTDGVSGLYEGNVFEATPDDRRQIGVISASFLIFNRVIGTGIFATPSTILSLSGSVGLSLIMWVIGTLIAMAGTAVYLEWGTAIPKNGGEKNYLEYVFRKPRFLVTAMYAAYAVLLGWAASNSVVFGEYILNAADVEVGRWNQRGIGLACITAAFLIHSFAVKWGLMLQNFLGVVKLVIIVFVVVAGWVALGGHMKIDPPHNFTNAFEGTTDTGYGIVMALYNVIWSFIGYSNANYALSETKNPTRTLKIAAPIAICSVGILYMLCNIAYFAAVPKEQFLSSGQTVAATFFGNMFGSRAEKVMSVFVALSAFGNVLSVIFSQGRIVQALGREGVLPLSKIWASNRPFNSPAAGLFEHWVVSVIIMLAPPPGDAYNFLVNLITYPLSIVNVFVSGGLVYIYVTKAKNFPDWAPGIRATLPVTIFFCLSNIYLVVAPYVPPSAGQSVYNDLPYYLHCVVALGIFALGAVYYLVWAVLMPRFGRYILVKETVIDADGWSRSVFTRMPLEQAEQQQQQQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAY0</accession>
    <name>A0A317XAY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative proteasome component Pup3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_564030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470431.1">
        <property type="nucleotide sequence ID" value="XM_025614392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAY0"/>
    <dbReference type="STRING" id="1450535.A0A317XAY0"/>
    <dbReference type="GeneID" id="37116535"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21100" checksum="EF0D509C9B0170D9" modified="2018-10-10" version="1">MVGKDCVAIACDLRLGMQALTVSNNFPKIFNYGPSTFLGLTGLATDVSTVSDLFRYKVNMYRLREERNIAPQTLANLVSSSLYERRFGPFFVSPVIAGINSTTGKPFICGFDSIGCIDFAKDFIVSGTASEQLFGTCEGLWEPDLSPEDLFETISQALLSAVDRDALSGWGAQVYIIEKDKVTKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB15</accession>
    <name>A0A317XB15_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_621215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471518.1">
        <property type="nucleotide sequence ID" value="XM_025616986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB15"/>
    <dbReference type="GeneID" id="37119129"/>
    <dbReference type="OrthoDB" id="4380184at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016435111" evidence="2">
        <location>
            <begin position="19"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="193" mass="20520" checksum="6E5C9247BC163384" modified="2018-10-10" version="1">MSTLFVASTLCLAPAVYGYGVAEVTARAHADCHPEDPPNDRLIGDPQDAVATEDTCEKIEVKHGFDIDAYSVSMVDITKDTSDRCHALGIYANEECMGLPNALIPFFPGDTQGETRCFKDTPFDKYLYVRLLCDADDKDKDGKDGKDGSPDQPESEADKSEAPEAPADASADTPADAPAAPSSGGLLSSLGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBL5</accession>
    <name>A0A317XBL5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trichothecene 3-O-acetyltransferase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_141709</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472704.1">
        <property type="nucleotide sequence ID" value="XM_025605726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBL5"/>
    <dbReference type="STRING" id="1450535.A0A317XBL5"/>
    <dbReference type="GeneID" id="37107869"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="3">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="464" mass="51038" checksum="8F506E73131B803F" modified="2018-10-10" version="1">MGSIAPEPVPSLTPLELIGPKGYLRYVFTFPLASDYEVKEVAAVLKAGYAAAIQRLPVMDCEAIPDLNARQGGVMKLRKVDNSKDDGILVKDMRMDAFPTYAELRAQHFPVAAFDADTFCRSDVWPTPGEPLPISLVQANFIRGGLILTWCILHMAGDGTSFQTWMQVWAEECRHAQGLDSKPVALPPAIFEDRERVMRSTGRNLGRPEDHPEYIVLPVKPPAGIPPKMLSKDHRAQVFYFSPEALSALKSDASPSNATEPTNVPWISTNDALSALLWRTVMAVQWPVETLEGDPVSFFNIALNGRLRTDPPVHPDTLGCFLEYIGVSMPVRKMLSSASLADLAVLIRQELQRVNNQFTDDVTTLIEGLDDISQIFPASLVDLPGFNCILSSWIGFKLYDIDWGTLLGGHIESVRTPHVGIINGLQIVLPSPPEGGMEVVIGVADGCLERLLNDPLWTKYAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCA2</accession>
    <name>A0A317XCA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_529617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472987.1">
        <property type="nucleotide sequence ID" value="XM_025610481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCA2"/>
    <dbReference type="STRING" id="1450535.A0A317XCA2"/>
    <dbReference type="GeneID" id="37112624"/>
    <dbReference type="OrthoDB" id="5307821at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF7">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE (AFU_ORTHOLOGUE AFUA_2G00830)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY96226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="290" mass="31614" checksum="4A29BB6E169E5869" modified="2018-10-10" version="1">MSPIHPVFRKEATALITGAASGIGLATAKLCYSHGMNLILIDKNEQALSTTSALFPSTTKSTTSTYAIDVSDMSAWKTLQTEVTSKYPSGIDFLMLNAGSAFKPAEGKTRWQDPEYFQKTFAVNTMGYTNGLAAFLDSVTGPNKEQPRAIILTGSKQGITNPPGDPAYNASKSAVKTITEQLSLDLHETYPNVAVHLLVPGWTYTGLTAGHASKPDGAWSAEQVVEYMNAKMVEGRFYILCPDNEVTEDLDRRRIAWAAGDLVHGRPALSRWRADWKQKASEGIAQMQFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCF4</accession>
    <name>A0A317XCF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="14">3.2.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">1,4-beta-D-xylan xylohydrolase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Beta-xylosidase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Beta-xylosidase xlnD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Xylobiase xlnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_508456</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Xylan 1,4-beta-xylosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="14"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472048.1">
        <property type="nucleotide sequence ID" value="XM_025609664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCF4"/>
    <dbReference type="STRING" id="1450535.A0A317XCF4"/>
    <dbReference type="GeneID" id="37111807"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001420">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000007">
        <property type="entry name" value="Exo-1,4-beta-xylosidase xlnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF13">
        <property type="entry name" value="EXO-1,4-BETA-XYLOSIDASE XLND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016388459" description="xylan 1,4-beta-xylosidase" evidence="19">
        <location>
            <begin position="17"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="20">
        <location>
            <begin position="697"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY95287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="791" mass="85294" checksum="6587FB95712A4376" modified="2018-10-10" version="1">MAALLAFAALLPTALGQANTSYVNYSIEANPDLWPLCVATLPLSFPDCSQGPLSSQLVCDTSATPYERAANLISLFTLEELIANTGNSGLGVSRLGLPPYQVWSEALHGLDRANFTDAGAYEWATSFPQPILTTAALNRTLIHQIASIISTQGRAFNNAGRYGLDVYAPNINAFRHPVWGRGQETPGEDVTLAAAYAYEYITGIQGDGSHLKLAATAKHFAGYDLENWHNHSRLGNDVIISPQDLSEYYTPQFHVAARDAHVHSVMCSYNAVNGIPTCASPYLLQTLLRDTFSFLPDGYVSSDCDAVYNIYNPHAYASSEAQAAADALRAGTDIDCGTTYQWHFNESVIAGEVARTDIERGLIRLYTTLVRLGYFDSTPSPYRNLSWSDVVSTDAWNVSYEAAVQGIVLLKNTQTTLPLTSSPANTSIALIGPWANATTQLQGNYYGTPPYLISPLAAFESSGYTVHFAPGTGISSINTTGFSAALSAAQSSDVIIYAGGIDNTIEAEALDRESIAWPGNQLSLIHELATYAGSTNKPLIVLQMGGGQVDSSSLKSNPNVSALIWGGYPGQSGGAALRDILTGVRAPAGRLVTTQYPASYAESFSALDMSLRPDNKSGNPGQTYKWYTGESVYEFGHGLFYTTFDEQPTNNTRALVFNIQDILSQPHPGEAVETITQNGLFNFTAQITNTGTVESDYTAMVFANTSDAGPAPYPNKWVVGWERLAKIEAGESRELRIEVPIGGLARVDVNGDWVVYPGSYEIGLNLERKVVVKVVLEGEESVVVKWPEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCH4</accession>
    <name>A0A317XCH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO94DRAFT_570642</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
            <orientation evidence="3">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473067.1">
        <property type="nucleotide sequence ID" value="XM_025614834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCH4"/>
    <dbReference type="STRING" id="1450535.A0A317XCH4"/>
    <dbReference type="GeneID" id="37116977"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2900:FF:000002">
        <property type="entry name" value="Mitochondrial intermembrane space import and assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="13" id="KW-0811">Translocation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016351496" description="Mitochondrial intermembrane space import and assembly protein 40" evidence="21">
        <location>
            <begin position="27"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="CHCH" evidence="22">
        <location>
            <begin position="180"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="93"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="266"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PWY96306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="294" mass="31606" checksum="A5AF0799B624E208" modified="2018-10-10" version="1">MQRQVRWLAGRMVCLLCLLCIRISNQLSPALLRAPAVAVRGPASRRLISTTPADSKPRSWKNTAARLGLAIGAVYYYNTSPIFAQTPSFSLLSQATSDPEPDTTLTLDSVKPKIREEKKASAPAPAPTPAPQDAQPSSDPSLMSPEELEAEAGQEGAFNPETGEINWDCPCLGGMAHGPCGEEFKAAFSCFVYSSEEPKGIDCIDKFQGMQNCFRQHPDVYGAELEDDEAAPAAPETGDEQPVTAAQIDAAPLPEEKRAQAQEIVAQTKQELTEKGELAESEVLVPKAAHDAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCK9</accession>
    <name>A0A317XCK9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_138709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472622.1">
        <property type="nucleotide sequence ID" value="XM_025605711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCK9"/>
    <dbReference type="GeneID" id="37107854"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="181" mass="19885" checksum="5AFDA64C773982B6" modified="2018-10-10" version="1">MRPKGGNEGGGVRRRGKKRREEEEGGRGGGGGRRSGDRMLLWWWWCGGAEGRNSNSSNSRCRGALVDSCRGTGRGIRSIATGCQVSQSIMLKPLGKRETKWPVAMTAQTLVLVAGNPTVAQAVERKKPREGKKMRECESPCCLFFLLLRSLPPGIKPFLSFRQAVTGRNAHQPHSVSPKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCT6</accession>
    <name>A0A317XCT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phenol 2-monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_509457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471519.1">
        <property type="nucleotide sequence ID" value="XM_025609703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCT6"/>
    <dbReference type="STRING" id="1450535.A0A317XCT6"/>
    <dbReference type="GeneID" id="37111846"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF20">
        <property type="entry name" value="2-MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="17"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="199"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="456"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="73820" checksum="2A10EC288DE0D419" modified="2018-10-10" version="1">MCKSSISDCPLLLTITSLIIGAGPSGLTVAYWLAQYGINARIIDKRGTKLFRGHADGLRSRTLELFDSMGFAHRVIEEGYHAAAFMFWRPDGKGGLHRTGQQRSTIHTSSPYRMALLSQGRIERFFLDVIKSTSGLEVERGVIGESLSYDESLEKDPQAYPITVQLRILSEEEATPAPNPGICPYQPALDDLEDLIQKRKHKVGTIETIRTKYLIGCDGAHSWTRKQLGIPFEGSHTDHIWGVMDVVPITDFPDIRWPSSIDSPEGHLLTITREGNMVRFYVPLQEDDEVVADSFDRSAVTLDMLRERVKKIMAPFYFDFKICHWWAAYQVGRRLTPTVNKGRMFLVGDAVHTHSPKIGLGMNMSIHDGFNLGWKLGLVLKGMASPSILDTYSSERHHLAQMVLDFDQKWASFFLKKEKQEQQGLEASPQEQDDIQAAMRQAFIDNEQFAEGHVTFYKSSPLVHKGSTTMAKHLVAGERFPAALICNQSDGQPWWTTRLLKSDGRFRILLLAGDMRLQDQQSCMSTLSESLTKLLKRFTPSEQKLDSVIEVKAIHSAPLDQVELRDFPPIVRQFDEDEGWDYTKVWSDSKCFWDEQCKGNAYEVWGVDRSRGAMVVLRPDQYVGWMGELDDVTGVTEYFEGILCERNPSPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD12</accession>
    <name>A0A317XD12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_126273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472238.1">
        <property type="nucleotide sequence ID" value="XM_025605614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD12"/>
    <dbReference type="GeneID" id="37107757"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="164" mass="18479" checksum="2358CDEBC5037BB7" modified="2018-10-10" version="1">MWCAVPASRRDSNPSPLPHLARFGVPLQQYRIMAPWSRNNPTVNSHLVLLVAGAKKTGLSSNRINRFGRVVLSSVTVYSPRKALSRSWWIQLGRTRPSLPAYQVVCAGNPWQGHMVSCVTVYLPKHSAWILTSLVVYKDAARSRRTLSSSSRTLIIHHPTLLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDE8</accession>
    <name>A0A317XDE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_542846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471321.1">
        <property type="nucleotide sequence ID" value="XM_025613111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDE8"/>
    <dbReference type="GeneID" id="37115254"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="238"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="606" mass="66870" checksum="89AF884A5E6D64CB" modified="2018-10-10" version="1">MTTNTIRQSAPTPGVPVSQTEAGMSIELFDVQRDLRVRTETGPRAAGALEGGLATREQQAPLSSEWTACVPLNRPIETDFIIPGNVGGFEHGLVCKAQEALRSALVHSSSGQQELRAFLQDERGIPMESVSLECLTWMLQDIGSAKFGSYVLDYFKHVAKSTLKQMCSRLLSNNVSNDERDGERDIFTFCTNAAAHKFLTTVLMVGGHDNDLTDYPRMRFSEYKKSAQAALDRIRLMTAPSLSLLQAILCGGFLHQGSGNTHYCYELTKAACRVATDLGMNLGNAGGSRNARAEEEIYCLLWCYMLDKNNAWKFDPTRSYFDPQSGVQDETSSLVKRLQLLSTLPQSARPMLHNSIDILLQKVEEVRQRIEKISLASPQCWKGVDAADEISALHFDNNSIRTTILYLSEQLQGQVLGSGELLLKSARQELSSLLSICLINEQHRAVGYLHWTLMYYPLTACFVLFCNAVMASNLEHLNLLKTVATVLMPSVSMSHPVAIIQRLVEDFVALSQPVFSNGSIGAGEVGQTSTLLQMPPSMLHHQPLPTNEAILTPAAPFWTEHTSTLLPPDLSETWTPDPTESQPGLLLDLSLDIPIPLDFDLAERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDF8</accession>
    <name>A0A317XDF8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_531519</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471331.1">
        <property type="nucleotide sequence ID" value="XM_025610917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDF8"/>
    <dbReference type="STRING" id="1450535.A0A317XDF8"/>
    <dbReference type="GeneID" id="37113060"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="555"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="592"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="629"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="665"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY94570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="704" mass="79471" checksum="D856204C6DFA27FB" modified="2018-10-10" version="1">MELSRFWRPRQWTLWLLFVSYAYAFYIPGYSIKRYNDDEHIPLLVNKIFSDHTQLQYAYFDLPFVCPPSGRSHGGSPFGSGQSISLNLGEILRGDRIMTSDFELQMGKNVECQALCTQEIGRKDVKSSRQLIQEGYVAEWIADNLPGATSFVTVDRSRKYYATGFKLGFQEFSPIDGKARYYINNHFTIVIRWRSAPEGGKVIVGFEIYPKSIRAADHLEGGCPKQVHEAHDGLELYIPPNTSKLREMYPGSSYIPEDDDELDDDATLKIPYTYSVYFKEENSVEWWNRWELYFSNQDEGSTTHWLAILNSMTIAGVLGVAVYVIWSRTVQGDIKGRGDGAMEDGKLKVRGTKSRLERKGDEQGADLERDADVSSDDEGLDDVSGWKLLHGDVFRVPQYSGLLAPLVGSGMQLLFMVSGLLLLSCLGVLNPSFRGGFVSVGMGLFVFAGLFSGYFSGRLYKTFGGTYWRKNTLITALFCPGLAFSLIFILNLFVWAQASSTAIPFSTLVGLLALWLLIQVPLVYVGSWYGYVRTTPWEHPTKTTSIARQVPPQPWYLHSIGGTLLTGLGPFAVLFIELLFVFKNLWQDKSGYYYVFGFLSAVSTVLMVTVSEVTIIATYSQLCAENYHWWWQSFLTGGSSAFWVFGYCVWYYIFHLHITGFVSSLLFFSYSFLACAVYGLLTGTVGFLTAYAFIRRIYSSVKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XES9</accession>
    <name>A0A317XES9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_483676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471891.1">
        <property type="nucleotide sequence ID" value="XM_025608932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XES9"/>
    <dbReference type="STRING" id="1450535.A0A317XES9"/>
    <dbReference type="GeneID" id="37111075"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000054">
        <property type="entry name" value="DCR2p Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="218"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="551" mass="62199" checksum="694EBF5144680F34" modified="2018-10-10" version="1">MTRRLVRAGVQLAIFASFVALLVVTLDNRFRVLPASIHGHLPSHYDGYAITDVTVVTCSSMNVFSNCQPSQESWSQVDKDLYLRTGWTSSAFVRFQRKKEEELLPTDKVVIDLKISRLVPEYIEDPEAEGETWEQRPGGIWLRRTAKRHASDSQKAITAIDVLFGADAVDPRIGWEVKDTPLLLDSRTEGLETRISVRRGNPPRTKKPVPRINENGRFKIMQLADLHLSTGLGACRDPVPAEPVPGQRCEADPRTLEFVERLLDEEQPDFVVLSGDQVNGETSRDAQSALFKSVKLLVDRKIPYAAIFGNHDDEGDLKRPELMTILEDLPYSLSTAGPEEVDGVGNYYVEVLGRGSTAHSALTLYLLDSHSYSPDERQFRGYDWIKPSQIRWFKNTAQGLKAKHHEYTHMHMNMAFIHIPVPEYRDTGNYYRGNWSEVPTAPGFNSGFKDALEEEGILFVSCGHDHVNDYCMLNRDNEEKPSLWMCYGGGAGFGGYGGYGGYVRRVRFYDFDMNPGRVVTYKRLEYGETEAKIDEMMIIDGGTVKGPEQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEU9</accession>
    <name>A0A317XEU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Allergen Asp f 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_592765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473512.1">
        <property type="nucleotide sequence ID" value="XM_025616159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEU9"/>
    <dbReference type="GeneID" id="37118302"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016436630" description="Allergen Asp f 4" evidence="2">
        <location>
            <begin position="20"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="29416" checksum="CF4450AAC83C2442" modified="2018-10-10" version="1">MHFTTPLLLAAALITPTFSSPTPTKPQHGHTHGHSRRQISIGASASISISIPSASSTSTSSGSSSDWTSTPSSGSESTSGFGTQTNSTGSGDTYIGNVGSPWGSNMLEVSSSSASSYKYVMELTLPSTSSSSDSWTVVFWNKYGPDGKMDGFYGYSALSFTMSPGDTKYVAFDEDTQGAFGAAEGSSLPTGSSGIYDCTWGEFDFGSTVNDDWSGFDVSAIQAQKNSATVQGLQMCDVLGGTCSSITADAGSVDNAYTEAEEDEGGIGGNISAGAVRIKSVLDYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFD9</accession>
    <name>A0A317XFD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ and TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_541877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472539.1">
        <property type="nucleotide sequence ID" value="XM_025613066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFD9"/>
    <dbReference type="STRING" id="1450535.A0A317XFD9"/>
    <dbReference type="GeneID" id="37115209"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052758">
        <property type="entry name" value="SRC_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44200:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="411"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="554" mass="60368" checksum="90E119490B955C6F" modified="2018-10-10" version="1">MAAARDDLRSSMDVDMNDPRLGSPSAATNGANGTHTEKSPTPPPHRANGSTADADSFKLAGNKFFKDGNYTRAIEEFNKALEICPDSSVYLSNRAAAYMAANKYLAALEDCERARVLDPTNTKIMYRQARILTSLGRPTDALDVLTRIEPPASATDRAAAEKMLRFVSQAEEALSQDRGVSMVLFCLDQARQLLGQGVKEPRKWTLMAAEAQLKMGNDNSFGKAQDIAIGMLRENSQDPDALMIRARAFYGMGDTDQALKLLKMCLGLDPDMKVAIKLLRTVQKLVRTKEEGNTAFKAKDYRRAIELWSEALTVDPKNKDMNAKILQNRAQAYINLKEFDSAVADCTEALRLDPGYVKAQKMRAKAYGGAGNWEEAVREYKAVAETNPAEKGIQEEIRRAEFELKKAQRKDYYKILGVSKEASEQEIKKAYRKLAIVYHPDKNRDGEAGDEKFKEIGEAYETLIDPQKRAAYDNGDDLMDPADMFSRGGGFGGMGGMGGMGGMGGMGGMGGMGGMGGTHINIDPSVLFNMMNGGGGFAHAGGQRGGGFPGGFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFI0</accession>
    <name>A0A317XFI0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_505869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbxX/CfxQ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473308.1">
        <property type="nucleotide sequence ID" value="XM_025609557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFI0"/>
    <dbReference type="STRING" id="1450535.A0A317XFI0"/>
    <dbReference type="GeneID" id="37111700"/>
    <dbReference type="OrthoDB" id="2423195at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000216">
        <property type="entry name" value="Type VII secretion ATPase EccA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041627">
        <property type="entry name" value="AAA_lid_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050773">
        <property type="entry name" value="CbxX/CfxQ_RuBisCO_ESX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN / ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43392:SF2">
        <property type="entry name" value="AAA-TYPE ATPASE FAMILY PROTEIN _ ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17866">
        <property type="entry name" value="AAA_lid_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="204"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="481"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="735" mass="82528" checksum="0DFB62312AC0C931" modified="2018-10-10" version="1">MFIRRADQLTKDPKSFDKFLAFMEDYTGEIFLILIGPPKDFCDMGASRRFTMKMDLKDYSNEEIYRLLVRILKKRSLHVEGGWDGENMKILARRICRRRTDTSFTNMLALRTVLEQVMGRQASRLCRSSRGVTAKCEKPPNYYFLTKSDLLGPAPLDMRERSEGWKQLQSMIGLQEVKEMIDDLALRANTNYHREIQGLPPIETSLNRVFLGPPGTGKTTVARIYGQLIAELGLISSGDVVLKDPSDFIGQHTGESEANTREILRATEGKVLVIDDAHMLYQGSGHGTNESDSHRIAVVDTLVANISSKPGEDRCIILTGYPDQMKEFFDNSNPGLQRRFLLEEAFRFQDYSVDQLAEILDLKMSRDGLTATDEARKAAIEVLSRALDRPNFGNGGDVENLLGKAKAAFNKRLKGVSDRQGKMIEPVDFDSEYDRAFKISKACESLFSTMIGMDPIITLFKDYQQMAAGMRLREIDPRPYVPFAYVFKGPPGTGKTTTARILGQVFYDMGFLSTSEVIECTATDMTGEYVGQTGPKVIKLLERALGKVLFIDEAYRLAGTSTGHSSTFAEEAIGELVDCMTKPRYARKLVIVLAGYSDDMDRLIQMNPGLRSRLPTDIVFPSMGPAHCFEFLEARLRKLHINVDRHGSDPSGEKYSTMLSMFSRLQKTESWANARDIETLARNIIFQVYKMQKSPGDLSIGLSISMDTVITSLGDLLHQRGQEDENDTPDNTGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVU2</accession>
    <name>A0A317UVU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Shugoshin C terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_551573</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461609.1">
        <property type="nucleotide sequence ID" value="XM_025613548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVU2"/>
    <dbReference type="GeneID" id="37115691"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045132">
        <property type="term" value="P:meiotic chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin N-terminal coiled-coil" evidence="12">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Shugoshin C-terminal" evidence="11">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="243"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="589"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="689"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="284"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY66154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="727" mass="80869" checksum="E71E3131704459FD" modified="2018-10-10" version="1">MQVMARLNESSAPTEHIEALKRRFVRQNREIARVNSIQSLRIRSLESEISHLLSENVSLREQVIRLSQDIERYEAARLLQDGVYDIKTRLDNKLAELNNLVADLGALPRRLCNKSTEKPPSADHTRSISDWRPKSTDDELNVRQDENGRLPVILEDKCYPRRTESQDLQDMEVNGTDIMRIPNLEGPVAMQPDAEDDGRSSNNSHDAEDDQSLSYEAHISTDDDAFLPPTLETRKRKKHNLAQMNVECSNADPGPSPVRDDSEARMNPGTKRKFSVHHGDRLESTPTHNDNLLPNLQSPSPVGRAGHSLSPGSEGTPSRGEIQPSKEGNINYRLAKRKALEHTDEETGSTNISILLPGKEDAAVAQEPTDKVTTPRLTGERGGKGGLSPISPKVDIISAQSRRTSISGQCRLDQPTDDKEHNGHTIQESKVPKIKPGTQSPSGPTTRSESRTSTFVPSEPMRPARRQRAIVSYTEPNLRDKMRRPTNELIAAVGDRPRRISGSLNARSDTTDDENLVKNEKWNDRKPRHSDFTSKESKLQTIETPTSLCTQQMNVSERKRKTSPASEIDITASQGIATGAHPQWVAKECNDEEPKGTDDHTETQPPWKMGNNTRNLPANACKERQTTGRQPRRHSSHPEHSGENRSQAADQDIRSIKSQDASPSEARAKNPAPTKTLEEFAILNPQALKATESTHIHSSATTLTDAKRSRRGQRAAAAAARRKSMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYF2</accession>
    <name>A0A317UYF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_540508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461805.1">
        <property type="nucleotide sequence ID" value="XM_025612928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYF2"/>
    <dbReference type="STRING" id="1450535.A0A317UYF2"/>
    <dbReference type="GeneID" id="37115071"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="30"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="156"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY67083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="392" mass="42725" checksum="83103CED2EFA1D6F" modified="2018-10-10" version="1">MVSTPTPTSTPFCLRWGILATGTIAATPAFARDLLHPPSSRSVTDVSHLLLAVASSRSTTIAQQFITRIGASSTIAYGSYESLVADPRIDAVYIASPHSHHYQNAMLALRAGKHVLCEKAFTVTANQAQRLMDTARERGCFLMEGLWTRLLPIAVRIRQEIEDGVIGSVVRVVADNSIGTDALHELRESYLTKRELAGGALMDLGVYPIHWILQALHQLPDRKPSTILSTMVPLGSAGVDESTMLIMTFPANPPSPASVQAIASASLRATGDSDGETPVVRIQGDEGEIQVYGRPWCPSKYRIVKREQRFGMVGEVDEFQFPIPGGAHGLCFEADEVARCVRDGRLESMSLPWEETLLVMGILDEVRRANGLSFPDTIESDKYPVPMAVKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYY4</accession>
    <name>A0A317UYY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_331312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000050">
        <property type="protein sequence ID" value="PWY66846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461782.1">
        <property type="nucleotide sequence ID" value="XM_025606979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYY4"/>
    <dbReference type="STRING" id="1450535.A0A317UYY4"/>
    <dbReference type="GeneID" id="37109122"/>
    <dbReference type="OrthoDB" id="2192830at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045030">
        <property type="entry name" value="LYSM1-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932:SF8">
        <property type="entry name" value="LD22649P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20932">
        <property type="entry name" value="LYSM AND PUTATIVE PEPTIDOGLYCAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="65644" checksum="EBDEE5A7B3814730" modified="2018-10-10" version="1">MSSNGGFADLFSLGTSSTTNTSRRSTSTVRSRTRRLISFTDDDVDENGRQMQSSGLSSMLSPDTSAVRARGATPSPNPSRGVSPIPMRHPSRATEAASRSKGNGSLDFLDVSWTSLQSLASSVLGSDIARPATNGTTKTHARKPSRPDAYPRLPTPSSAPSTWGPSAPSTPEIGSGTQEERQALVQAKKREALLLADTGPAWSTTARHKRRDSSDRTGHSTVDPEHDEDALAYIHHVQATDTITGVTIRYGCQPAVFRKANGFWPSDSIQGRKTVLLPVDSCSVKGRPIRPRIEEDLMGEGCLKRESLEDLSGSSIAPASSSGPVEALTPATPAAEFEGDRTWKHESWVHIEGFPAPVEIGRVPRRTLGFFPRTRRKSLAYTDSVPSPVSGRGGTTVSSSSSPVEPAFAQPAIPAWSRPHADSSASRTSSKTKPGVRHQRQRSGIQLSGPGVGTLDHDSTAPGPAMDGLSKFFAQHLPNLAPVAHPPDFESSSESTSTAAANTPTGLDHLGGAVESWVRKMTTRAKASLNELQQPQSSPKDDPAQAIGRRGNGDLIELNDGLESRSSSNVVSEPRWKPDLLRSGSSLHDGTALRGRFLSPSPGTSRTRSGGDRAKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0E2</accession>
    <name>A0A317V0E2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_479353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000050">
        <property type="protein sequence ID" value="PWY66841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461777.1">
        <property type="nucleotide sequence ID" value="XM_025608742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0E2"/>
    <dbReference type="STRING" id="1450535.A0A317V0E2"/>
    <dbReference type="GeneID" id="37110885"/>
    <dbReference type="OrthoDB" id="275936at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="34548" checksum="16FE62E8CC7B0211" modified="2018-10-10" version="1">MPRNALSPEAPLTMSTISEQSISTDWNTNRLGARLGVDVASAATAGALTCPVITVIDRAIIEKAAKGVSIRQTITSCFRSMLTKPGGFFLSTPFLLIYTLYTSTYLTANTIDTFTSTMRNKPFETVFPGTAKFLTTTAVNMGICVYKDARFARIFGASSPPTSASASPSAPPSQSAPASASTSTSAPASCHPSGAAKVPKISYSLFCLRDSITIFASFNIPALVAPSIPDTIAATPGMKAALAQFSCPALMQFVSTPMHLLGLDLYNRQPPGGLGWRERASRIRRDYVPSCFARMGKIVPAYGVGGVVNVRMRASLMEYLEGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0E8</accession>
    <name>A0A317V0E8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase subunit K, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_331525</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000050">
        <property type="protein sequence ID" value="PWY66851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461787.1">
        <property type="nucleotide sequence ID" value="XM_025606980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0E8"/>
    <dbReference type="STRING" id="1450535.A0A317V0E8"/>
    <dbReference type="GeneID" id="37109123"/>
    <dbReference type="OrthoDB" id="2094445at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021278">
        <property type="entry name" value="ATP19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28074:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT K, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11022">
        <property type="entry name" value="ATP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY66851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="7759" checksum="FA5F0FBFD3201444" modified="2018-10-10" version="1">MVVYYQIAGKQIGSHVLAMGVLGALFGGVGLATRGGSQPKPAAPPIQASSKDEETFIQDFLKQMNGEDKKKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2I3</accession>
    <name>A0A317V2I3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462156.1">
        <property type="nucleotide sequence ID" value="XM_025612856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2I3"/>
    <dbReference type="STRING" id="1450535.A0A317V2I3"/>
    <dbReference type="GeneID" id="37114999"/>
    <dbReference type="OrthoDB" id="4480078at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016418024" evidence="1">
        <location>
            <begin position="22"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="283" mass="31792" checksum="2B1504E25A3E374D" modified="2018-10-10" version="1">MPPSKTTTRLLILLTPPALLTYTTHRYLSTLEAKYPPVDPTTTTSLALRTPSSPTQHCPEIDVYEARAVPVKSLLKRYKHILQINGQSQLITAEDNPPKNEKERRKETLTKSWTLTFLNTAPLLHEASIFGLFLNRSYSPGDTGLTTLTSTPTTKKGERLLNGIFTIESFTPSHSPSTPNTLPGLILSWSIPPEPILFFEKMAKWGYPFRLMSGGRHEIGISPVYIHEGEEVVDVRFASAHDYEVLESEGGLESQKMIPKWTGRLHRGYARFLLHSAIQDLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2M3</accession>
    <name>A0A317V2M3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine-rich repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_611470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462186.1">
        <property type="nucleotide sequence ID" value="XM_025616637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2M3"/>
    <dbReference type="GeneID" id="37118780"/>
    <dbReference type="OrthoDB" id="4463088at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Leucine-rich repeat" evidence="1">
        <location>
            <begin position="142"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="452" mass="52086" checksum="E1155BD91D1A5557" modified="2018-10-10" version="1">MRHLPPELLCMIGNYVDDKPTQRALAECSRYFHNLFMPRLYSSIEPFTSIPYTDAKPSQLKSSRTFALIRLLWSRPDLARHVQHMEFHLHNGYRDAWVGVLLTRLSRLKTITAHACPIALDINLIFEKAALRQSPFHRDVPFPHLNKVRFVQLPGHYPVYAETLIPFFYFPALRSVEGLGVRESLRPYVHPKLRGIKNIGSPVREITVSGPSHFRTVGLWIEACSNLERVHVNIEPSRAVDLEWYQSRVKGVRKSLLPAKRTLKSLCLLLIDFRVRSHYLRDHYEALRGVLDGPFGSFKEFEVLEHLSIRHPNLVTLSGEDTGGEHSKDGERLIDLLPRSLKSLEITEIQRKFLAGLIADILFLGQHRESSVPCLESIALVVIEEWPPYVASLKSLALMLDAGRIYRDRWDDSGDSDEDEYSDENFCLYGYEYSDEYSDEDEEDEEDEEVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V640</accession>
    <name>A0A317V640_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_307252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461979.1">
        <property type="nucleotide sequence ID" value="XM_025606801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V640"/>
    <dbReference type="STRING" id="1450535.A0A317V640"/>
    <dbReference type="GeneID" id="37108944"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY67630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="673" mass="75284" checksum="0E2ADA91710A5C8D" modified="2018-10-10" version="1">MTPLGGPRRRLRSNHACLNCRRKKTRCPGEKPACSCCVRLNQPCSYTPITRISMGSPPKDRLAELEEKVNLILTGNIPPRESGLGTKPPQSNNYASNDPYPPTVELEDVETPDPSPSVIARAIDLYVERCHRQPVWCFDFDGPGEPGSLPEELISSLLALTLRYLHEPDRGQHYAENAKTMIMLRIANGTVELATIESLCLLSYSSFIDGDMHLGQFYLGLASQLCRSGMLDVAATYSPEDPHGERKKRLFWSLQLLEQSYGRQTGLLRIPIEIWRPPYFADDGDKEPPKETAPIPPPLPQDTVGCSEPDDTGIWSMSIQFGWVWSKVRGYVSDCASSRMREPWRHESMYSVVLSDLTEIENRTPLCHRYDHVRFYERQGEELSNNLSYWVPWLKLQFMYHAILTVLNHPFLYIMASRHNPNLAIPNSFWRRSSELVVLHATWIVRLIDMVLEKEVQLSDPFFAHVAAIAATVQLYYCCAGDPRLKYKSRVDLAKCRAFLKHRILDQMMRVASGSDGVSYETWVPSKIHLSIPLMWDILQFRCADQSAEGISDGRLLHPSLAMAMVGHGSEEASTLEVIVTASPEVTVNTADGGQAVPLPLYPTPVTSKGNAGGKAAVRDRLVAPIDSLMVNTPWLWTDAAPLGDMDGSLGYDSAGPAIGDAEFSSWWNLGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7H6</accession>
    <name>A0A317V7H6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_527430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462426.1">
        <property type="nucleotide sequence ID" value="XM_025610385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7H6"/>
    <dbReference type="STRING" id="1450535.A0A317V7H6"/>
    <dbReference type="GeneID" id="37112528"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="454" mass="49197" checksum="4AE0D04AC2F1BCC0" modified="2018-10-10" version="1">MEHHSPDLTKRITTIIYGVIGAFTDRAPVGLEESRHAPRVEAQGLEPPQRCSGNQPASFTFVNTLHNHTTSTSPASSSSRFPPRVHHHFTPSSSASPSIRSFSSTSSVKSKSTKMPVADVDDTVGFMTAARTFKLPQNYGSPAVHSAVDASSEQGSVSKADADFPADPFDHGATVSRDDIFAPSSPTVPGDLENNSGFEEFGVTVETPKAREASNVAGDFSPQDDTTVAGSAQPVGSDAVTPDQINDEQEDRTDLTTFKSWGVPVVRDKPAAKVRRIIINGLPTTWCSPAKVLSLVHGGIIESISISDHGTAHILFCDHEACQAFYDKYPNGIDLGRERRHTVFVEMGKDVDVVSTKLSFNLSVGSTRAVRAVGVDMKITMEQLVKIASVNGRKVEKILDSYVPGDARNVVFRFCNIEDAVRFRSALVRDADWEHCNVQYATDPCEFATGMHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7I7</accession>
    <name>A0A317V7I7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeats protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_628725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462112.1">
        <property type="nucleotide sequence ID" value="XM_025617504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7I7"/>
    <dbReference type="STRING" id="1450535.A0A317V7I7"/>
    <dbReference type="GeneID" id="37119647"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="573"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY68090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="671" mass="76009" checksum="503AFA281DE5112C" modified="2018-10-10" version="1">MGKKNKKSAEHKERVAAKQSKKADKKEKKGKGKGKDADSDVEDADLDAILAQYAEEQAKFLKVTEVVGGPPTPRSSATVLASPSNRNELLIYGGEYFDGNLATFFNNLFVYNIDRGEWREVTSPNSPLPRSGHAWCRGGNTGGVYLFGGEFSSPKQGTFYHYNDFWHLDPSTREWSRLETKGKGPPARSGHRMTYFKNYIILFGGFQDTSQQTKYLQDLWIYDCSRYTWFNPTLPPASQKPDPRSSFSLLPHETGAVLYGGYSRVKATTGINGKPVKNGPQRMTMKPMVHQDTWFLRVTPPAPDAPANAAPTVRWERRKKPANAPNPARAGATMAYHKGRGIMFGGVHDVELSEEGIDSEFFDTMFAWNTDRNRFFPLALRRPRAQGKKQLANQMKSRDRSKADEEELLQNLKALEAKGGIRSQDDDDLELNAPKKEEEPEKPEKPAIVRFEMPHQRFNAQLAVQDDTLFIFGGTFEKGDREFTFNDLYSIDLVKLDGVKEIFYNEPGNWHLLNEADSDEEMDEDDEEDLEDEEEEDAMSLDTASPAPTEVTVPSVTQELEQLEVEEQEGEPSVQDSRPLPRPFESLREYFSRTSEDWQRILLETLKEKGIATEKNIKELRKDAFNMAEEKWWDSREEVMALEDEQEEAGIGEVVSIADRGDNAGGAGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9J5</accession>
    <name>A0A317V9J5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_477687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462495.1">
        <property type="nucleotide sequence ID" value="XM_025608655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9J5"/>
    <dbReference type="STRING" id="1450535.A0A317V9J5"/>
    <dbReference type="GeneID" id="37110798"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF38">
        <property type="entry name" value="PROLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="44"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY69667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="543" mass="59928" checksum="64E37ADB153128C4" modified="2018-10-10" version="1">MSHRDPESALASADLKSGTMHEMIERDLLDERYKVTQRGLKNRHVQLMALGGTIGTGLFVGSGQALHIGGPLSLLLGYIFISGLVYALVTGIAEIGAYMPVHGGTMSYHGFRYVSRSMGFAMGYLYWYSLGILVPYEVVAASMVIDYWHPDVNLAVWITIMLVIIVLLNCLPVGVYGETEFWFSGIKIITLVGLLLLSFILFWGGGPNRQRLGFHYWKDPGVMNTYLVSGDAGRFVGLLQCIVKSAIAFIFAPELVVISGGEMESPRRNVPKAARRYIYRLVIFYILGALAIGVICSSNAKQLTAGSGTDASSSPFVVAISNAGIPVLDSIVNAAILTSAWSAGNSFLYMSSRSLYSLAVSGNAPSIFKSCNRWGVPYFAVAISSLFSLLAYMAVGSGSYTVFNWLINFTNTSGFISWICCSIVYFRFNKAVTVQGVEKPYSSRMQPWGMYIGLGGSVFLALINGFTCFFPSEWSASTFFTAYIGIPAFVVLYFGHRIVFWRDPWAWKSEEVDLHTGLREIMEAEKPERVRDTWWKKLALLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VB51</accession>
    <name>A0A317VB51_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_560364</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462982.1">
        <property type="nucleotide sequence ID" value="XM_025614147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VB51"/>
    <dbReference type="STRING" id="1450535.A0A317VB51"/>
    <dbReference type="GeneID" id="37116290"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="29"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY71584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="359" mass="39003" checksum="D2F0E72B9824FF1E" modified="2018-10-10" version="1">MIAIGLESSANKFGVGIILHPDDGSTPQVLANVRHTYVTPPGEGFLPKDTARHHRAWVVKLVKKALRDARITPRDVDCICFTKGPGMGAPLQSAAIAARMLSLLWGKELVGVNHCVGHIEMGRLITGSTNPVVLYVSGGNTQVIAYSSQRYRIFGETLDIAVGNCLDRFARTLRISNDPAPGYNIEQLAKKGKKLVDLPYTVKGMDISMSGILAAIDGLAVQYGLDGEWNDAEETSVAASDDLENAKPTRADLCFSLQETVYSMLVEITERAMAHVGSKEVLIVGGVGCNERLQEMMGIMARDRGGTIHATDERYCIDNGIMIAQAGLLAYKSGSTTPLKDSTCTQRFRTDEVFVKWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VF70</accession>
    <name>A0A317VF70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Store-operated calcium entry-associated regulatory factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Transmembrane protein 66</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_260928</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SARAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462990.1">
        <property type="nucleotide sequence ID" value="XM_025606491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VF70"/>
    <dbReference type="STRING" id="1450535.A0A317VF70"/>
    <dbReference type="GeneID" id="37108634"/>
    <dbReference type="OrthoDB" id="20303at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001256">
        <property type="term" value="P:regulation of store-operated calcium entry"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009567">
        <property type="entry name" value="SARAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15929:SF0">
        <property type="entry name" value="STORE-OPERATED CALCIUM ENTRY-ASSOCIATED REGULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06682">
        <property type="entry name" value="SARAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016395833" description="Store-operated calcium entry-associated regulatory factor" evidence="16">
        <location>
            <begin position="22"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="247"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="205"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY71592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="303" mass="32808" checksum="20C3A85E5198A3F7" modified="2018-10-10" version="1">MHILLILQLLFSFLLPSYVVADRSSKSPSNNAILLSRVHSLTLHGGRLTSSRRVSPIPQLKCTGPSRRICNMYQIDTMRCTNEGYGYDEEDIQWTCTAELPQEFKLGSTDVVCEGYRNADDKWVLKGSCGVEYRLLLTELGEEKFGRDTSSSSGELGPIGTLIFWGFMALVFGIIVIAMLNECFGTQRGERVNVGGHGGGGGGGPPRPPPPYSSSPPPYYSSSDPHTSGSSWRPGFWTGALGGGAAGYTLGRRSNRPSGSSYTTTRYPSSRRWDDSGEGSSGSRTTQLSSTTTSTGFGSTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFL4</accession>
    <name>A0A317VFL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_242860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463449.1">
        <property type="nucleotide sequence ID" value="XM_025606383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFL4"/>
    <dbReference type="STRING" id="1450535.A0A317VFL4"/>
    <dbReference type="GeneID" id="37108526"/>
    <dbReference type="OrthoDB" id="4223756at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="110" mass="12782" checksum="EF85AE38FD1D0328" modified="2018-10-10" version="1">MSNRFRSQQRKKNARSIASEDPWKVDTPFGPPQIPHFPGRGIRRIRNTLQKLSSSARAEKELLKQKNRLKVPLTERNVDALVTEQRFTDACYPGNHSRELQISAWLERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGA9</accession>
    <name>A0A317VGA9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_245068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463243.1">
        <property type="nucleotide sequence ID" value="XM_025606397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGA9"/>
    <dbReference type="GeneID" id="37108540"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="162" mass="17960" checksum="F55BDAFE822AA70A" modified="2018-10-10" version="1">MEFGVWMDRCEVESRLSIRSNQTTIRPYTVAPTRASSVVQQRAADRYLQPVLPPPRTLHSTGQEGDQQRTMAAELPSPVVAMRASKMGQPARWKDQESLPMLSRLRIMKELRAGGREAGSGSTGSSKRQEGTREDSRGIPSGAWIQTGDPWVALMEKPAQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGP8</accession>
    <name>A0A317VGP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_240106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463370.1">
        <property type="nucleotide sequence ID" value="XM_025606362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGP8"/>
    <dbReference type="STRING" id="1450535.A0A317VGP8"/>
    <dbReference type="GeneID" id="37108505"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="418"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="640"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY73105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="950" mass="102691" checksum="7859FD0E9A641B27" modified="2018-10-10" version="1">MTAKGDFSIPMHRTPSSRRPQGRAIRRWQLPICAGICAAAILLVGASPRELLLPTDATTRHEFYDGLHQCYDVERQQQARRAGDSTRQNPRWNPVAGQTTPVVIQNATLFDGESTLADPVDIVFEAGVITSISATGLGDDTPQNANVIDVHGKHVTPGLVDLHSHHLLLPFPQLAATSDVNERPLLGPITPFVRAIDGFTPSDPAIRIIASGGVTSSLVLPGSANIVGGEAYPVKNLLFPGADREPVIEELLLEHGIPEPDRQRYLKMACGENPKGVYHHTRLGLAWLLREKLAEARELLERQSDWCRAAFEIEGIKFGQGQHIASFLERQGRRPDSFQLETFVALIRGELNVNVHCYTPEDLERMLAVLHEFGIHPQAFHHALEAWQVPELLKRQEPNITIATFADNALFKAEAYGANLRAAQVLNDHGVRVAFKSDHTGEGNYAKYLLDQASIGHSFGLPADKALQSVTSIPAQSMQQGHRIGYVRPSYDADIVIWDSHPLQVGATPVEVFIDGRALLKDDVTDQLIPSSSGDIDQHAPETRPIVDLEERNDVCSQSRLVFTGIRTALIDSPRLEQAPEDLVFVVEDNRVSCFGTKSACVRGEDEERITEITLKNGYITPGLVAFGNNLGIQAIPPESSTGDGSSGTTGDPLNEAKNVHFAKYGVHLHGEAFDRARIGGVTKAITPPHGTGLIRGVSTGLRTGPHATILDGGIWKDDVALHLSIGQGAKDGDTPTIGSGIDYLRRILQQGSKNGAEQRSVYTQAANGSLPLVIEVYNEDDIAQLILVKREFPAVNLIVYGGHGAALVAKPLAEAGIPVILTGNRGAPDKWEKKDALPGPPLSDSPAKVLIEAGVQLGLAVRGDSKIHGLAREARWAAKQAGLSEKQAIALVSSNIEQILGLGRTVDNDDAYKGDFVLWEGNPLRGEGSVVVAVREDGVIADCWPDSGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VH91</accession>
    <name>A0A317VH91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcriptional regulator PacG/VIB-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_247463</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Transcription factor that acts as a positive regulator of nonrepressible acid phosphatase activity. Is a major regulator of responses to nitrogen and carbon starvation and is essential for the expression of genes involved in vegetative incompatibility (like pin-c, het-6, and tol). Vegetative incompatibility is a non-self-recognition system ubiquitous in filamentous fungi which results in programmed cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463311.1">
        <property type="nucleotide sequence ID" value="XM_025606422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VH91"/>
    <dbReference type="STRING" id="1450535.A0A317VH91"/>
    <dbReference type="GeneID" id="37108565"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000002">
        <property type="entry name" value="PhoG like DNA-binding family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NDT80" evidence="11">
        <location>
            <begin position="81"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="9">
        <location>
            <begin position="81"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="328"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="490"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="229"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY72537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="593" mass="64436" checksum="647E8E5F16DA0036" modified="2018-10-10" version="1">MEGFDTMAMPYLASPLSLSNIQSTDYLNSMSGMDLPDQRSNFDSETFVSGDDISFPQHALPPASLKRFPSGYEDPFTDIVAPFEPAPPEQPPDSSIDHNNKLLSFSMPAYGFTLLDYSLRRTSISLSAQLHGMFFLAESPWTTSPTENAPPQQGAELTCYRRNLFQITGSVTLPRSLRYIMTEQGDRIPILAQELTVSATESVEGNPVKIISVPWKTPAANINPAAEDGNNVSSGSGGNTNSATSIKVEKEPPPIPLDIMAGQDLDTDYATFPIAWKRLQFRVATANNGRRKELQQHFLIRLKVVATLSTGAKIPICEVQSGPVIVRGRSPRNFQSRKDLPLSGSAAASRKSAQVAQSATVNRTPTSDSAPHSSLTPAKAKVTVKSSSPETSVSQGGVATQQASPDWTQIPPPVGGTLPSTTLPHSTVYSQSSPEFSRPAEVQRHPAAVAAPINLSLLEDDDGRESINPADPVRSASYTNDMSHKILSMESSAPPTKMRKLSHGLPETQSRSTSSLPLLNTTNMQQPFASTLPFPNESADLLYEYFPLGLDDWQAPVDAVYRPHVVHHTTLPEVKFVTARGRSKRYFTAEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIU8</accession>
    <name>A0A317VIU8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_539020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463406.1">
        <property type="nucleotide sequence ID" value="XM_025612614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIU8"/>
    <dbReference type="STRING" id="1450535.A0A317VIU8"/>
    <dbReference type="GeneID" id="37114757"/>
    <dbReference type="OrthoDB" id="6372431at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="226"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY73141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="505" mass="55295" checksum="41B3C3053EE83DFD" modified="2018-10-10" version="1">MSQTQRSRYLKTGAIVGAVLLMLLWLSPSKPTVSNFGTQQPSTGVAPLTDKCTKPHDPSKPLIQYALMIDAGSQGSRIHVYRFNNCGSTPELEDEVFEQTEKRQGGSGLSSYKEDAEGAAKSLDPLMQVALKSVPAEYQSCSPVAVKATAGLRMLGPEMSQRILEAVRTRLETVYPFPVVSREMGGVQIMDGSDEGVYAWITTNYLLGKIGGPDETPTAAIFDLGGGSTQIVFQPTFPKSPSGGMPEHLAEGDHKYALQFGGRHFDLYQHSHLGYGLMAAREAVHKAIVEAKLAASTVDMSWLKQPITNPCIGPGMEREVELTFDNDHALAGKVTVKMVGPKEGTNAAAQCRGLTEKILNKDAGCKLAPCSFNGVHQPSLEKTFTREDVYIFSYFFDRTKPLGMPDSFTLEELHQLTATVCAGEPEWKIFEGVEDALPQLRDRPEWCLDLNFMLGLLHTGYEMPLSREVKIAKKIKNNELGWCLGASLPLLSQESGWTCRVKEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJF9</accession>
    <name>A0A317VJF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arrestin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_589522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463423.1">
        <property type="nucleotide sequence ID" value="XM_025615951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJF9"/>
    <dbReference type="STRING" id="1450535.A0A317VJF9"/>
    <dbReference type="GeneID" id="37118094"/>
    <dbReference type="OrthoDB" id="2238745at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF174">
        <property type="entry name" value="ARRESTIN-RELATED TRAFFICKING ADAPTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="441"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY73158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="829" mass="91430" checksum="36B9D69CCF781040" modified="2018-10-10" version="1">MTTHISHLEQDFSGSVTTTTTTSSDSQLSCAAPESLPLFHNLLGFRSDPRRSIETSTVVGDSVAVGKLPRPGHRRRESILRKLAGPRENAKRLLRLGTPIHPPLTPPTHPMPMPETHRPRPVSEIVLSPNDAQMLATTGLRAGRLRSHSSSTVSAAQPTSTSATQTMPASDPTVPFPTLRNEKIVATGSGITVGVALTEPVLFLQGYDQNDPSTKKSAILRGQLHLKITKSVKVKKISICFRGHAQTDWPDGIPPKKVHFHDKKDLVTHGVMYFNHGDTALMQNDYGAHFYQHAKPVTSVTGKDGATTSTRELLSKTGSSTSLSHNGQFTPKDMKRLSLQSNQSRSFGKNDLPPPPVHTQRNYRLFPVGDYLYSFEFPIDGSLPETIKTDLGSVRYDIEAIVERAGAFRPNLLGTLEVPVIRTPAEGSLEQVEPIAISRNWEDQLHYDIVISGKSFPLGSQVPIAFKLTPLAKVECHRIKVYVTENIQHWTSDKSVHRFQPAKKVLLFEKRADSASTSTYPGSSMRVMAGGGIDWDRRAAAARGEEIVDRNRTNLLGNLSSDAGVGPTEMEFNVQLPSCQEMRNRDESQRLHFDTTYENIQINHWIKIVLRLSKVDERDPGKRRHFEISIDSPFHLLSCKATQANIYLPAYTSPDSEPSPQAQEFECGCPGAPAVHRNGSRNGSSRQSLSSDREELPIGGAVSRSFTNGSGGLTRPPQAHLADEPNDRAPAPPRPMHLLRAPSFAPPPFEDVPPPPPLVTPPPEYNSIVGDNDRESVLQDYFSRLSCYEEHADDDRGRGRVDVPLTPGGRVNRSMDVPREWVRLEESAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJY0</accession>
    <name>A0A317VJY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility Het-C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_525780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463163.1">
        <property type="nucleotide sequence ID" value="XM_025610323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJY0"/>
    <dbReference type="STRING" id="1450535.A0A317VJY0"/>
    <dbReference type="GeneID" id="37112466"/>
    <dbReference type="OrthoDB" id="2506204at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010816">
        <property type="entry name" value="Het-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052577">
        <property type="entry name" value="VWA7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905">
        <property type="entry name" value="NG37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14905:SF7">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07217">
        <property type="entry name" value="Het-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016370755" evidence="2">
        <location>
            <begin position="29"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="778"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="795"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY72210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="808" mass="89281" checksum="368D570E3C036E1F" modified="2018-10-10" version="1">MAARMRLGTHVLLVLGLLLVVLPTKTWAFGAGNIASISAVEGKNWRHGDIEDMLKTVAFIKGHKWTSTMIKRVYFGNWLRDYSQAMDVGTLKSLPTETIRILVWILSFMTFGYATAEFEVTSDRLGVYRPEEHIDNPKDYADNQDARQYDERLRGPIRQVELDIDPETGMKNYIANEQGGWATSAAYIKYSLARSIHYGRTYTHGSRKGNDEDLCEALRCLGQGLHTLEDFAAHTNYCELALREMGFRNVFPHTGVNTQMNVRGHQVFPLVTGTFGMVDFFHSVLGEATDHFTQSEVNEMDIALGDAEANSSSGSLGAFTSLLGNIPGTKDLVAEAEELKRCSEAQESANRAGGSRSGYTTRGTAREVDDYSSSRSRGFEDDFPTSSRSRGFGDDVRSFRANENERPAGSAQSGSGLQDLDPSKTIAQIYPILEFRDKVVRKLSSIIEKIPGLEAIVEKITETLTVFIMSLLAPFIRPIINAASKSLQSGSSGVIDASGQHQYEPWTDPDCTDPTHSLLSKDHFSNILNEPAGQVASAILKYVAPRVLHAWENINVSEEQVLDDCLKVFHHPALRNMRNEAHRTMFEAVESWVHSRPGRGADLDDVLSAEGVRQGKNSSGEGGHSHAHGGGHSHGSHQQRPPQSQQPQGSSLPWDKLSSLPIPGISNLNKLNSAFGNLMVGGSSRDEASTSENPSQYESYQQTQYTQQQSSHQEHGYQYQYQSHSQSHTQEQSYHHPPPPDFADSGYDAHNGSHRRHHGDHPHQHYPPPPGGSPPRRPSGGYEEQSYSSYSSHGHGSGYGQNYGGGYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLR6</accession>
    <name>A0A317VLR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_559570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463913.1">
        <property type="nucleotide sequence ID" value="XM_025614077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLR6"/>
    <dbReference type="STRING" id="1450535.A0A317VLR6"/>
    <dbReference type="GeneID" id="37116220"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY75286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="141" mass="16445" checksum="DB9B37CF48BBC289" modified="2018-10-10" version="1">MQVFLKLDYILWFYNILAAGYLVISGTFTFLQEKIKTLDNDVIKDSIKESIIKAIRNLLLLEISCSCLVLGVTLMMWLSWERRNNYIWLGGDWLIIAMMTVIITNLLIVVSITLIIIYKFKYEIEISIRSYKILPKLSNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VMT8</accession>
    <name>A0A317VMT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NPD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_538712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463744.1">
        <property type="nucleotide sequence ID" value="XM_025612546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VMT8"/>
    <dbReference type="STRING" id="1450535.A0A317VMT8"/>
    <dbReference type="GeneID" id="37114689"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY74551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="355" mass="37553" checksum="CC7CC68675053FCF" modified="2018-10-10" version="1">MASPQKIRTTLTDLLKINHPVLLAGMNVAAGPKLAAAVTNAGGLGVIGGVGYTPDMLREQIAELKSFLTDKNAPFGVDLLLPQVGGSARKTNYDYTKGKLDALVDIIIESGAKLFVSAVGIPPKHVVDKLHAAGILYMNMIGHPKHVQKSLDAGADIICAQGGEGGGHTGNVPTTILIPTVAKLCQGKKSPLTGLPVQVVAAGGLYNGNSVAAALMLGASAVWIGTRFILADEAGAPKAHQEAVRTASFDDTIRTIIFTGRPLRVRNNEYIKNWEENRQDEIKQLTSKGVIPAEYDMENLPDDVDDETLENARPYLMGKVAAVVNEKKPAKAIVDELVTDAAALLQQGSKMLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTX9</accession>
    <name>A0A317VTX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DUF887-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_538364</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464300.1">
        <property type="nucleotide sequence ID" value="XM_025612475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTX9"/>
    <dbReference type="STRING" id="1450535.A0A317VTX9"/>
    <dbReference type="GeneID" id="37114618"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="68"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY76487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="388" mass="44011" checksum="36557B3E890FE1A4" modified="2018-10-10" version="1">MLDPFPPPPAWLRDFVEPWALYLNVPALTEHAHEVVIAFVGYLFIHFILSPVLSPVLFPRYYPKLNPRTKLNWDVHVVSLVQSTFINAMALWVMFVDDERNSMSTGERIYGYTGACGLVSAFAAGYFVYDLIVSTIYVKLFGIGMLFHGISALWVFSFGFRPFVNFYSPIFILYELSSPFLNIHWFLDKVNLTGSKIQWYNGMLLLFTFFSCRLVWGTYQSIAVYRDMWYALKQTWDATAASTPLDPVDITTQVFQLRGGSAAGLEMSKYAPYTAGGVPTWLVLTYVISNVVLNFLNYFWFSKMVETVLKRFRGPAEKSGPAGKPSKEEKIHHLQEDIAQKVILEAASKLEQEEGSPFLDGISEEKVASAIDSGLNEELRKRKAKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUX8</accession>
    <name>A0A317VUX8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">rhamnogalacturonan hydrolase</fullName>
            <ecNumber evidence="14">3.2.1.171</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_568079</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pectinolytic enzymes consist of four classes of enzymes: pectine lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Hydrolyzes alpha-D-galacturonopyranosyl-(1,2)-alpha-L-rhamnopyranosyl linkages in the backbone of the hairy regions of pectins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Endohydrolysis of alpha-D-GalA-(1-&gt;2)-alpha-L-Rha glycosidic bond in the rhamnogalacturonan I backbone with initial inversion of anomeric configuration releasing oligosaccharides with beta-D-GalA at the reducing end.</text>
            <dbReference type="EC" id="3.2.1.171"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.171" evidence="14"/>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464615.1">
        <property type="nucleotide sequence ID" value="XM_025614660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUX8"/>
    <dbReference type="STRING" id="1450535.A0A317VUX8"/>
    <dbReference type="GeneID" id="37116803"/>
    <dbReference type="OrthoDB" id="2268901at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000025">
        <property type="entry name" value="Probable rhamnogalacturonase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016295999" description="rhamnogalacturonan hydrolase" evidence="16">
        <location>
            <begin position="19"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="17">
        <location>
            <begin position="39"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00051850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY78103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="446" mass="47114" checksum="FEC45388847B0D85" modified="2018-10-10" version="1">MSALSILALALAPLLVNGQLSGSVGPLTSASSKAAYKTCNVLDYGAVADNSTDLGPAITSAWDECSDGGLIYIPSGNYALETWVTLDSGKATAIQLDGIIYRTGTDGGNMILIENTSDFELFSSTDEGAVQGFGYVYHREGSLSGPRILRLQDVSDFAVHDLILVDAPAFHFVMDTCSNGEVYNMAIRGGNSGGLDGIDVWGSNIWVHDIEVTNKDECVTVKSPANNIQVESIYCNWSGGCAMGSLGADTDITDILYRNVYTWSSNQMYMIKSNGGSGTVKNTLLENFIGHGNAYSLYINSYWSSMTAVAGDGVELSNITFKNWKGTEADGAERGPLKVVCSDTAPCTDITIEDFAMWTESGNEQTYTCESAYGDGFCLKDSDSTTSYTTTVTVTTAPSGYSAATMAADLSTAFGTDEPIPIPTMPTSFYPGLTPISSLGAAATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VV42</accession>
    <name>A0A317VV42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S28e</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_588568</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464418.1">
        <property type="nucleotide sequence ID" value="XM_025615889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VV42"/>
    <dbReference type="STRING" id="1450535.A0A317VV42"/>
    <dbReference type="GeneID" id="37118032"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY77231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="68" mass="7639" checksum="21E5AB2A435908DA" modified="2018-10-10" version="1">MDSAKQPAKLVKVTRVLGRTGSRGGVTQVRVEFMDDTSRSIIRNVKGPVKVDDILCLLESEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVY4</accession>
    <name>A0A317VVY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_605358</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464077.1">
        <property type="nucleotide sequence ID" value="XM_025616487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVY4"/>
    <dbReference type="GeneID" id="37118630"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000006">
        <property type="entry name" value="2-oxoglutarate-Fe(II) type oxidoreductase hxnY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF5">
        <property type="entry name" value="MAJOR FACILITATOR-TYPE TRANSPORTER HXNZ-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="482"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="732"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="784"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="178"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="410"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY76080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="892" mass="98568" checksum="C31EBC9D451A6A6D" modified="2018-10-10" version="1">MAPSAPPILDFSSFYGGDSAAKAQLVEAVRNSCLYNGFFQITGHRVPIELQHRVMRCAQRFFELPLEEKLKIDKNHNTFNRGYELLRSQMLEVGTGPELKEGLYIGQEIPEDHPYYLQKKLNSGPNQWPPTVEDKEEFQRTSMEYYNAVFDLAKDVLGLLALTLDVNEDYFDPLTDGAVATMRMLHYPAQPKDADEKLNRGIGAHTDFGCITLLLQDEVDGLQVLDAPTGEWLDVQPVPGAYVVNLGNLFMRMANDRYKSNIHRVINKSGRERYSIPFFFSGNPDYLCECLPNCCAEGEAPKYPPITVEDMVTASYKESYGRAEQYKREMEEKAKLKMETVSATAAVEQKRDESHVYSNSIVGEEKGVVIDDPEVEQFYGSSTSEAYRLKSELVGKCMEEIGMGRFQWKLFVVTGFGWIVDNFASQGISSVQPAIELEFPGIVQVSYSSVAYYTGLILGASFWGISSDLIGRKPAFNSTLLLAGIFLCGAAGTMNFVAFSAMWAVIGTAAGGNVPVDSMIFLEFVPGSHQYLLTALSAWWNLGQLIVSLLAWVFLANFACPSDSTPATCHRSENMGWRYTLITLGALSLAFTCIRWFVFKLPETPRYLLSKGKDQAAVDAVNYVARENGKPEPLTIGMFQEIDARLGITQGESTEGPGLTTKQIIQENMKDFRSTHYQALFATRKLGIHTTIIWVIWLTIGIAYPLYFNFLPSYLDTKFSSNSSLSTTYRDYCIESAVGIVGPISAAYLVTTFFGRRWMMGISSIVTGVFLFAYVGVNSPTSSLAFACITGMLGNFGTSPPLPPLLHHPRVNEVIEYAIMYAFTPESFPAPHRGTGTGTAASLLRFGGLCASLIASQTGFTTAPIYASAALWVVVGVVCFGLPFETHGHAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VX10</accession>
    <name>A0A317VX10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c oxidase assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_537916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464641.1">
        <property type="nucleotide sequence ID" value="XM_025612380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VX10"/>
    <dbReference type="STRING" id="1450535.A0A317VX10"/>
    <dbReference type="GeneID" id="37114523"/>
    <dbReference type="OrthoDB" id="76305at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY78129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="89" mass="10090" checksum="F5021DD44D1AB6CD" modified="2018-10-10" version="1">MSRASKLTLAATGLGTAGIICFVHWAQEQEKVGMHKAVEQDMEKQRIRRERQAEFEMQRALEEEYRKLQTVSPSVDETSGGQTHQGQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZK8</accession>
    <name>A0A317VZK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_577649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464517.1">
        <property type="nucleotide sequence ID" value="XM_025615184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZK8"/>
    <dbReference type="STRING" id="1450535.A0A317VZK8"/>
    <dbReference type="GeneID" id="37117327"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY77330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="521" mass="58037" checksum="4F6E216C9F7599DD" modified="2018-10-10" version="1">MRPVQRYGLDDQRHFRLLTAPTQAKHVQCTEELPICQLCKRHGWPCERGLRVVFQDDAAQRGVGFGRHGTLTSQPQLWQEDSEFRSVPLNAYVGRWIFVNTVSSNFTEVAGNMDGVSTGDEGSDILSEAEELDDKLPMDPCLAHPLTVYPDSESYLLEFFIHGIGPNCALTTINNPYISLITPLAFCDTTLRNAVISVAANQLRLLGDSRFSHQALVYKNKALKGLQQAISLGNIDDGTIATVLMLCFHAISHESDPSWVTHLQGGLDLISSVPCNATTGDSLRKFFEMYFVAHAIMSRTASPGKRCVKGKYTWSDNDNLDEIDTIMGCSRRLMGLINDISDLPLNVGHAVREVDTSDEETEDRPIDSNISRASKIACSLSTITQTLPDHSKDRDDLSQIAETKRLAALIYLIGRVNDADMIIDEGTTKFSLVSMLINIISTLPDTPTLLWPLYILGHSGLEDEDHRRFVLDRLERMQRIRNLGSVRRARVAVKHAFQVFDMRLSTARVKNAEAFSSISLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZS7</accession>
    <name>A0A317VZS7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS8m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_537703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464821.1">
        <property type="nucleotide sequence ID" value="XM_025612331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZS7"/>
    <dbReference type="STRING" id="1450535.A0A317VZS7"/>
    <dbReference type="GeneID" id="37114474"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000006">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000005">
        <property type="entry name" value="Mitochondrial 40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY78512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="170" mass="18602" checksum="6CBFE954C22EFFA0" modified="2018-10-10" version="1">MSLVNLSHVCSHLNNACKARLGLTSIPNSKLHLKLCLALQNDGLISSVVRGGPTPPPVHPILGTPNAVDEVENIEPLTQSNIATRRLWLGLKYWQSEPVLGKLSMVSKPTRRVTIDVAGLRRVIRGERSETVEGIRSPGEVLYLSTDKGILEARECVEKKLGGLVLCRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W326</accession>
    <name>A0A317W326_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial cytochrome c oxidase assembly factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_429004</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465556.1">
        <property type="nucleotide sequence ID" value="XM_025607470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W326"/>
    <dbReference type="GeneID" id="37109613"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY80954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9962" checksum="D3B2C0DBEEE2D931" modified="2018-10-10" version="1" fragment="single">MSSILRRLQGGNLEVFKFGMYIIFPIGWMYYFGTNLDDRFSVPGFWPTTEQSHKIPLEKEEIDCELARMRMVDAVRREKRQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W444</accession>
    <name>A0A317W444_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_601882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465331.1">
        <property type="nucleotide sequence ID" value="XM_025616402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W444"/>
    <dbReference type="GeneID" id="37118545"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="148" mass="17084" checksum="C8DA21FA41AD63EE" modified="2018-10-10" version="1" fragment="single">MHLAKWVPMDNIYPEAVADEFEWALWYAVWKARKALNLPHTMIANMYRREADDKLLTHKVLIFLAVMITRLGGNDFARHTVVPIMAITVFAGYKLRILQAHYCLEGLVIRKSHLLSFTDKDVALPNMDIVMRFMAAKMVGNTKNLHVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4R1</accession>
    <name>A0A317W4R1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_471182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465151.1">
        <property type="nucleotide sequence ID" value="XM_025608370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4R1"/>
    <dbReference type="STRING" id="1450535.A0A317W4R1"/>
    <dbReference type="GeneID" id="37110513"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000055">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="549"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="829" mass="92147" checksum="D17E190E5BD68555" modified="2018-10-10" version="1">MVETRSASIPAAIMSDSASTIQTVPYDETIAATAPVAVRSASFPVPVDCASCSEGRSHSASSGGAWDQSGPALSQQNTRSLRNRFIALPEAGASTVSLRSLRNSIPSIIVNDAASRPVSRPGSRWSERRWGGLRNKKSGEFDRDEDDTPPVPPIQAPFNGIPLDIPNSALDGLGTQSMRFSKRGSLIQEESKRQLQQQIQQEEARRREAGQRTQNREDQQQQVPAEREMASPDVASEQNSTEPENMEAPPRRSKPASTLRVRHSAIASRAISADEDMLSRRVRLMYEKGEENVTDSEVAKSMAMENGVLWEDGPTSMETSRLSGPSISGTDTKSVVSSLGPDNTPAIKREAHELAGGIEYWQNIKAGDVDRYGFIRSPTSNSTEGIDPSPIQRVSTSLLLASETPRRKHSIRPPSAIGGNRSFTGLTGRSPTRKLSEPSIRPTSSHSMYSSFMMRRSTSRFRRAANHLPHNRDRRVKDEASDMLTHPTGPVTPGEKQDAAAARAARKKEWEREDKWTKMARPIRSPDGGGMTFEFDTTSSKLIERTWKGIPDRWRATAWYAFLKASARLHSNSPSEEELIEAFNEYQLISSPDDVQIDIDVPRTITSHIMFRRRYRGGQRLLFRVLHAMSLYFPDTGYVQGMAALAATLLAYYDEEHAFIMLVRLWQLRGLERLYQSGFAGLMEALGDFEREWLEKGEVAAKLNEIGIPPTAYGTRWYLTLFNYSIPFPAQLRVWDVFMLLGDADDLTVPGSSGKGSKKEAPTSAFGNGLDVLHATSAALIDGMRDIILESDFENAMKVLTSWVPIKDVELFMRVAKAEWKVHRRKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W760</accession>
    <name>A0A317W760_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_536936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465793.1">
        <property type="nucleotide sequence ID" value="XM_025612153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W760"/>
    <dbReference type="STRING" id="1450535.A0A317W760"/>
    <dbReference type="GeneID" id="37114296"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY81725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="683" mass="75847" checksum="AFC5A9856D8CE879" modified="2018-10-10" version="1">MNGPSNISKDAGSFPQRSPVSTPREPLNPEPSKENTDKSTRRKACDTCQRRKIKCDLSTKARCSQCEKLGISCTRNKRHKAQLRRQAMINHLEGNLERMESRLQGLGFTVGDNDLPSSSPPSEILDDIPTFPWPTQIAEATNDTDLEHIYTSPQPEATIPAAEESPIPSIPQLFKHLDYPPAISSCFNVPRYLGGILNPGSFSLISPEGLEWIAQKTGDEPLDHLTQLVSTEEHDGFVADYPLHCVSSRRVFCPLPPQEDIVHLLHHYMEYFNAMFPVFRQSDILFLFPGEHVDIRSQSPGQWACINAVLAVSYMLPQNGASPQIGHQKSWLFLKNALEAVGELYLGPPDIQGLQALLVMAILFLAASAARPCNFLISVAIHISDQLGLGRAEDVSTFSVEETQHRQTIFWFAYCLDREISFRFGEPPVQNDDAISAALPTEAPTCDIYSMPTSDQPGSFSAFRSVCELARIRGEVYQHLYSASAANRPFHQILASVGQLDEKLQTWKNSIPSEYQPDSQAVTPFRQSPVSLSLLHIHYTYYNCMIAIHSLIAARGINSAQDLTDNPAFSIQPGSFANPRVLLSASLTSKAARASINLMKYLPQDDITLGITMYYPTVALKTLASSIVRNPRDTSQIYNMRILDQAEAFLSSTTLSATSEGMRRLGKHCAEYRSVAERAMKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8E6</accession>
    <name>A0A317W8E6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_587225</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465580.1">
        <property type="nucleotide sequence ID" value="XM_025615810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8E6"/>
    <dbReference type="GeneID" id="37117953"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY81512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="672" mass="75225" checksum="66C980CFCBB44F3E" modified="2018-10-10" version="1">MPGGKATTVSSSLPRRHRRGLTRSAAACERCRRRKQKCDARTPTCGACKAAGASCVPSERLVVRQAHPECQCGLLRDQLQTLRHQYETLLQQFEQLQGQTSGKSPRSNSNAPDASGPSPSGIISVSRSHVSPMHEEWRKQNLIFNCDIPYTGRILLPTFSHRSRVRDTNGSALSSAWKLWGDDPGLVDAPLRLTTIPPESDSEAYLKLVGTFFDRRWPYLPVLHRPTFLREHLSPFLSRRVSSGISRFLVNMVCAIATAEKPLHQEESHYSHRAFFNQATQDMHLVIGTGDFECVQCLLLLCMYGYNEPQSVNLWYTSGLALQLAIGIDLHRKESLAGRDNLSAEMVKRVFWSAYVTNCIMAINMGRPLGIQESDITMSLPLQLTDDELDNSPAVLDHTSIVPQVTDTSTFIHIIRLRKINAVIYSSFHSIGQTRPGAEELESRRKQYFSDLNHWVSTAPRYMQTTSTFQSPHWFQIAFHHAVLTLYRPSRGAPMPSSEDLRICTESAIGLISSYSALYAMNQIKYTFVAIHALFMAAITMLYALRASPQLRHDLTKSIVQTNILTFLTLFRGISNGRMVGEKCSEIVERLGDCILSLFDDATGAGVDVDTEFQSWFGLQSHAFTKSAHGDSVKGMENKSPDYPDARVDLPWADLFLEGIDIGSTDVWSFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8J1</accession>
    <name>A0A317W8J1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">2OG-Fe(II) oxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_536827</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465620.1">
        <property type="nucleotide sequence ID" value="XM_025612121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8J1"/>
    <dbReference type="STRING" id="1450535.A0A317W8J1"/>
    <dbReference type="GeneID" id="37114264"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="204"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY81552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="358" mass="40049" checksum="E7F0A6B9B76E8707" modified="2018-10-10" version="1">MANSQYTHVELLTLHGPEYRRVSTAPPRPPRDDEIPVLDLAGIDGDADARAALAASIRAAAQNTGFFYIKDHGISQDLIENALTQAKAFFHQPEEEKQKVSNFKLQHMDGYHAVGTTQVNKTETKDRKETFSLRYNARNDPTVDSSKSSARAWDDSQLWAGTAHLPNFRETTIAFWQARLALARKMVRIFALALDLPETYFDDVVTHPGSDGLYVHYPATPDADREKTDVDVGIGSHTDIQCFTLLWQDMSGGLQVLSSSDEWLDARPIPGTLVVNIGDFLQRLSNNRFRSTVHRVYNRQGTSRYSMPFFLGFNPESVCKVVPSCVDEEHPALYEPISCGQWHRDRLALAQGKKAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9M3</accession>
    <name>A0A317W9M3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Concanavalin A-like lectin/glucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_147963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465746.1">
        <property type="nucleotide sequence ID" value="XM_025605776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9M3"/>
    <dbReference type="GeneID" id="37107919"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY81678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26289" checksum="47A2420ACEDDED68" modified="2018-10-10" version="1">MRYSSMAVPLAFAARAAATTADAWAFGNGFYTGPPTNAHITKATWSLVPPAVPSGVTVKNTDDEVWVSLWIGLSSTAGDYDADLYQPLLNWSPDNESQGCPADDDEWCVAASTYTPDGQNGQAYVTVPTNTQVDFEVYVENDKVYQVVTMDGKTVSKESDALDNPLLYLYSGDECYTGSGDCGTLQSYSWNNITIHLSAADETFGNTVSLYSGSSTNGLSTSDGGKTWHTDAIKINKDTFADVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WB92</accession>
    <name>A0A317WB92_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_469654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465980.1">
        <property type="nucleotide sequence ID" value="XM_025608296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WB92"/>
    <dbReference type="STRING" id="1450535.A0A317WB92"/>
    <dbReference type="GeneID" id="37110439"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001704">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000432">
        <property type="entry name" value="zinc finger protein Gfi-1b isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="435"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY83195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="569" mass="63198" checksum="5AACBE9C0AF6C196" modified="2018-10-10" version="1">MASHTKKDDFCLECHWEAFHLDGKETEDPSEAQPDQWNCPDQVHTPLPHCEVDEQCHVDEDCCDVDDCSVNCSSVCDGFVDCDEALVCSESHCDEDHCKNVDPVCFDEHCFDDSNVDGEHSLESLLGLGSPLNLETNDLLSPTTIPPSQVEQPKTVTQPAAGLVAPASSNDTFLNSYAVPVSHCHSHSHQHFHCHDFSKDAHHAANSWLPLQNAVNPADVFHMMACPDLSGCHQFHVHEAQACPVPDKPADDSASNPFACFHIPHIPHHHHPPTEMKSPALPHKPTNNWKPCRTHVHRCRTHGHAHVHPYGPYSPYSRHSRSSVSSQLSPGETPPPLDGGTSSVLTSPEYAPDTELFMCQWATTTDGVKMRCGATFADACALQEHLVGCHMATVEGAKGTGYYCCWEGCHRPDEPFSQKSKLQGHFLTHSNYKNFKCSVCGKMFARQATLERHERSHRGEKPYKCSECGKSFTDSSELKTHSRTHTGEKPFKCTHPGCDFQTGDSSNMSSHRLTHGERRHKCHHLGCTKSFTRHATDQLKRHLKTTHKENITMPSPVAEQFGLAFSEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD32</accession>
    <name>A0A317WD32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_536592</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465897.1">
        <property type="nucleotide sequence ID" value="XM_025612047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD32"/>
    <dbReference type="STRING" id="1450535.A0A317WD32"/>
    <dbReference type="GeneID" id="37114190"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.490:FF:000024">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048867">
        <property type="entry name" value="WHD_ORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21312">
        <property type="entry name" value="WHD_ORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="97"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="591"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="287"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY83112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="800" mass="88428" checksum="4F7026B80AE5D9E4" modified="2018-10-10" version="1">MASDSADETDRSRSRKSSVRKRAQLWMTKGGLVRDDSDDELGEEDHPWEWIYDLDDENEEQATADGLEDTPKSSRRRSSRPNTKRRRTIIGARMGSFECALGQVVLLKSPESGKDWIGIITEFVEEEDEDAEGEVLKLANIMWFASPDEFMSTRNKRRADALPNEQYLTADFNVNPLTSINGKATVMSKDAFYAKYPGGNPPKGKDALAEFNKCIVCRRGVNQVQGRYTDEFVWEDVYHEDRIFELITMIKEGLKVAKKRKQVDNDYVDTKEEDDFVPTTPRKRQKVATNATPQSRRQKSFTTPAHKRIVVKKPLEFTPLGTRVLSPSHFASPYRQARTLLHVSTVPTSLPCRKTEFETVYSHLSAAIMEGTGACIYISGTPGTGKTATVREVVAQLNSAVLAEEMDDFIFVEINGMKVTDPHQSYSLLWEALKGDRVSPSHALDLLEREFSHPSPRRVSCVVLMDELDQLVTKNQSVMYNFFNWPALRHSRLIVLAVANTMDLPERTLSNKISSRLGLTRITFPGYKHTDLMEIISTRLANVPGNIVDADAIQFASRKVAAVSGDARRALDICRRAVEIAEQDSEAAVKDLDADRIDADDTESLPPTPSKTPARRERALKQSSQLSPQKKPPTKPHSVGRVTIATIKQAIHEATSTPLQQSLRCLPLAAKLFLAAMLARVRRTGISESTFGDVIDEAKRIADAAVAVAGAAGAGIREFLLGGGNSARVRALGYAAMELTSSGVLALEYGAGAKGPLGSAAIPHRGERSGKVRLRIAAEDVKIAFREDEEAKGLGLGMDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE13</accession>
    <name>A0A317WE13_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_468392</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466444.1">
        <property type="nucleotide sequence ID" value="XM_025608248.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WE13"/>
    <dbReference type="GeneID" id="37110391"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="96"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="1057"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="562"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1163"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1204"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="813"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="897"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1243"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1290"/>
            <end position="1312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY84519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1360" mass="154453" checksum="77B25C7FA9F48EBE" modified="2018-10-10" version="1">MSLHIYIAHTGEHFLQDPVSFASLDALRSWITRYTSIPPQRQILMTARGKNVKIQTLATESEVFVYDRRYVSEPNSFELPELPPPQPLQAENPPDTLTNQTDLQAWRNLYLARKTWAVNLTERCESADKQTHEHNERTDVINRAASVALENLKTHVGTLEHRFQEAQSWANDLLSQQQAALDGWRRALSNLDSIPARKDFPFLGRPSTPTKGRDKALGTLRDYVDTDEVQRAGSEAPDVSARFAHQVSNTEKNVSKIAADTQRLIDEAFPASVDSVDNILDEVKTISKKIQSDYEHVLALPNNQKTLANISRLALSHTKDLLPSLFDVSNEIQAGLEEAVRRYNAAMKAALSQMRLISSIELRLADVQNQISTMTFQSEVFDAIYTVFHMPLVYGSVLIESVRRREFNDKMKNDSLTLAEEMSVFRDEEQRRRKKWLKNMADFISISDSTTPGIEVNLRGQVQEWPMVSRKEVESYIEDLKTKTGMGNHAQELCQLFKELDTPTRLQRRRAKAFKQGSLFDLSRSSLLLRSDDMVRSLKDEKVKLEDRLKGSESRVRKLEDLLHRQSHMSRPSSGNFSLEFPSSPASPHPDSLSRRSSVSSRRMSSNQAPEEKALVQRITRLEAELATERDLVQRLQREAHAERQSNTDKIQEAQSTKKDLIGNLEARQREFDDERRFLEGELKRLRIRTEELEEEMDRNLDSREHEKQDADERIHHLEMELQDAHARAEDELRKAGQMIEQLQSEKDAGDTLRARIDELQNQVAEDERKDKENTHALQVAFLNLSPGGAVPAEIPNIIKAIEVLSEGLTIHAKSAEESATKAVAESKALEERLGQMESEAEELRKRAASQESELSRAHIELAEERSKLSIVSSELEDERSKLITLQSQFAAGETGSDALRERVTEEERKLTNLAQRLAEVESLARQSEEEVTAWKKKVEAMSEAEQQATVRFETCGFRSQELSKQLFAQVEKLERMLEHLGFTIIRQDGDIVVQRSSKVNALSGTGDSLSQSGVVSVRPDASLLDWMHADTKEEETDKFMAFMESLYQFDVDIFGDAVVKRVKDIEVLARKWQKEARGYRDKYHRVQSEAHEKIAYRTFKEGDLALFLPTRNQAIRSWAAFNVGAPHYFLREQDAHKLQTRDWLLARITKIEERVVDLSKSMNGANPDRRSIGEVSDGTSFDDENPFELSDGLRWYLLDATEEKPGAPATPGLGKSTVAPAHVDAKGSIRLKRTSAGGNVARTLTKSLDSRRNSSNSKKGHSSTPSQRGNESTTDLVRQAEQDPAASLHSREAVPRPDEGTERTHQRRISDGRASPFSPRVEDLDASSIRSPRRSTARYRPWEKLWSVDYRLESGNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEA8</accession>
    <name>A0A317WEA8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AAR2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_536196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466544.1">
        <property type="nucleotide sequence ID" value="XM_025611959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEA8"/>
    <dbReference type="STRING" id="1450535.A0A317WEA8"/>
    <dbReference type="GeneID" id="37114102"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.550:FF:000003">
        <property type="entry name" value="AAR2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="3">
        <location>
            <begin position="8"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="2">
        <location>
            <begin position="237"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY84619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="449" mass="50930" checksum="E5828A9DDA675BA2" modified="2018-10-10" version="1">MTSSVSPSPTILLPHLPPKTLVGIDLITFTSTPNFHGIRYLPSGWHFLYTGTTESLSLRSGGWFYVGDLNTLGEHQDGAIIPAHTSADIIIWKWNTDTETLSPLTANSDADKQEAMRHKANLGAIWQRGGLFRYCSRVSPAALSQQNSGRPVQYEIDEEDEQEGRQTWRDLTDRLTPGLLMRVVGDPVRDVDGRPRWMVTSASSAQRDNDVIPGITDTEQAEELEKVTGEKESEFSFLPVDLKRTWREGAIGRERTEAAQDRSWALGDLVQRFSNSGGERGGEAQVLGELQFTFLMILTLMNYSCLQQWKRLLELVLTCRSAIRDREMLVSGVLRLLLLQLKRCDDVEGGLFDLDGEEGGEFLRKLLIKFRRSLYEIVDGTESVVKIEFDKLEAWVKEEYDWELNREVVVRRGMVQLEDGEQVELDMHDDDEDDELGEYAPMVVDLEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHG0</accession>
    <name>A0A317WHG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose-5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_536271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466602.1">
        <property type="nucleotide sequence ID" value="XM_025611976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHG0"/>
    <dbReference type="STRING" id="1450535.A0A317WHG0"/>
    <dbReference type="GeneID" id="37114119"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY84677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17175" checksum="04677CA05E10F30E" modified="2018-10-10" version="1">MSDPKPLRIVMACDEAGQPYKETLKAALEKNPLVECILDVGVNSTSDKTAYPHPAVAGAKLIKEGKADRGLFICGTGLGVAISANKVPGIRAVTAHDSFSVERSILSNDAQVLCFGQRVIGIELAKKLANEWVTYRFDPKSASAAKVQAISDYERELAGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WI70</accession>
    <name>A0A317WI70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_95470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466752.1">
        <property type="nucleotide sequence ID" value="XM_025617758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WI70"/>
    <dbReference type="STRING" id="1450535.A0A317WI70"/>
    <dbReference type="GeneID" id="37119901"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY85735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="202" mass="23009" checksum="840C5B7ACECDA646" modified="2018-10-10" version="1">MEPRKTPPEYFLEVFADTTTVRDVLKGILNLIFFHRYFPSIRPTTFEVLDFTLPAINDVDLETLIESRISTLVRQHSSVTSAPDGSGGGGVRGRIAVEFYEKRRRRSGIWFGGLAGKGEEEVCWEVWNLDVTIATPRTESERAKVRKAMENMLQKAALKILAVVNRDKDHIPPITTSDSNPFPYRIVLNPRPDGWQNRFGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ30</accession>
    <name>A0A317WJ30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Rheb small monomeric GTPase RhbA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_517894</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466668.1">
        <property type="nucleotide sequence ID" value="XM_025610014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ30"/>
    <dbReference type="STRING" id="1450535.A0A317WJ30"/>
    <dbReference type="GeneID" id="37112157"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY85651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="20943" checksum="D369A38A56230877" modified="2018-10-10" version="1">MPSAPKQRKIAIVGSRSVGKSSLTVRFVEHHFVESYYPTIENTFSRIIKYNGQDYATEIVDTAGQDEYSILNSKHFIGIHGYIIAYSVASRQSFDMVRVIRDKILNHLGADHVPLVLVGNKSDLKSEQRQVSLDEGRQLCEEFHCAFTEASARLDYNVAKAFDLMIGEIEKSQNPSQPAGSNKCAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKA2</accession>
    <name>A0A317WKA2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_556958</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467086.1">
        <property type="nucleotide sequence ID" value="XM_025613904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKA2"/>
    <dbReference type="STRING" id="1450535.A0A317WKA2"/>
    <dbReference type="GeneID" id="37116047"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="436"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="323"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY86495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="528" mass="60889" checksum="C52BCE67758A583C" modified="2018-10-10" version="1">MRFHGIDAFDPILTLNPWTGEQNTLTVHSLVKFFQRHNIANDLSRHIVPSVWGPFCDDGSPEMNFDAELRLAQRLERGLLVLFHMADIARDTERLKHRRKPLAPVVSGRLFVLGKMLDEYDELPQHRKQLMSFEDYTNHVYTVLKWGHVEADIGRRRLEFRGWLDEQTEIDFHASLRMLRELMERMLLRHGPKDWHRDAKNEYSVISWFLLKQPPRSLAKLFLSPQNECCDIEVKATDCGVRKCRFSDPLDNYWKAWKNVPDLNCQDCDCKRRPALIDARGREFNRAAERYLREIDVLSTLQSTRPLFSSYLRIRSLAKSPSNPELQQARSELETTLTDLTADLDDLVESVRAIEQDPYRFGLELEEVQRRRSLVNDVGAEIEKMREELQRAVTASGGAGGGGGLPNPADFDNVLSPSAENRGDDYYAAMEQQRQMELMHEQDEQLDGVFRTVGNLRQQADDMGRELEEQGVMIDEVDTLADRVGGKLQNGMSKLKYIIRKNEDTMSSFCIAVLIFVLVLLLILLIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKQ1</accession>
    <name>A0A317WKQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SNF7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_585636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467272.1">
        <property type="nucleotide sequence ID" value="XM_025615702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKQ1"/>
    <dbReference type="STRING" id="1450535.A0A317WKQ1"/>
    <dbReference type="GeneID" id="37117845"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF18">
        <property type="entry name" value="SORTING PROTEIN SNF7 FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16692)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="467" mass="52043" checksum="765E7FDD4B3A227B" modified="2018-10-10" version="1">MPTLLQYILSQDSFRKNRLPSLYSDFPIHRKTNPEGYTTNVAAWEHALASAARHGYIISSSSHGHPSAQKTNHLVLRADESLLRDLEIPECGRPVALGAVFDDATRNRTMVPLHLYRSNPASLRKPQWGIDTSVLSPWAVMSWGMKQLKGVVVGSEEATPRLQAQELVLVKNLKEAADRVVKKATGHNPSKTDLVYSKESFVSEFSGVLEEGSRLSDADMDVLLLYLSRDSGAIAYDGKTIKFRTSDAPKDITEQDTAVASIKTLMSTMTKQVENLENKIVELNSTAKMALQNKNRVSALSAVRSKKLAEHNLKQRLDTLMQLEEVYSKIEQATDQVQFVKVMEASTGALRGLHTQIGGAARVEDVVEELREEMSKVDEVGNIMNEAGPQIDETEIDDELEELENRERQEMEEKEAEETRKKLAELDNLEQRAKEAARTAAGEQAVNSELEERLSRMSVEEGPRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLE6</accession>
    <name>A0A317WLE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_535318</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467421.1">
        <property type="nucleotide sequence ID" value="XM_025611756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLE6"/>
    <dbReference type="STRING" id="1450535.A0A317WLE6"/>
    <dbReference type="GeneID" id="37113899"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF11">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY87213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="313" mass="34374" checksum="39E23F622E332E54" modified="2018-10-10" version="1">MTPPKTIVVFGATGQQGGSLIQYILNDPHLSSTYQIRAITRDPSTPAAQSLKTAGVEVFPADANDPSSLLPALQNSHMVFSMTLPNFFAPDAKQIEIAQGKAIADAAVASGTEHIIFSTLPHVSKISNGKYTKVEYFDAKAEVEEYIRGLPIKSTFYAPGWFMQNFGGNMRPRTVEGADGKKVLVNVVGPGTKLPLIDPSRDTGVFLGGVLREPERWLGRVVQAAAEVYSYEEVAGMMSEVLGVEVQYQVVEREVFEGDLPPVFADRLVEMVRYIEEFGYFGPGTEEMVSRTVGETKDRLTTLREYLVREGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLF4</accession>
    <name>A0A317WLF4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha and gamma adaptin binding protein p34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_71589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467431.1">
        <property type="nucleotide sequence ID" value="XM_025617619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLF4"/>
    <dbReference type="STRING" id="1450535.A0A317WLF4"/>
    <dbReference type="GeneID" id="37119762"/>
    <dbReference type="OrthoDB" id="10261384at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034627">
        <property type="entry name" value="Irc6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28043:SF1">
        <property type="entry name" value="INCREASED RECOMBINATION CENTERS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10199">
        <property type="entry name" value="Adaptin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="44406" checksum="E51894DFED131B4E" modified="2018-10-10" version="1">MPPSPPSPPPPTTSKPIPNPRRLLILTPTTHSQTIIPPLLHTLTGTPVTTPPTTTTPTPPLSSSETLVPSINTTTTTTTFAGYTTHPPLHLSNKYYSADIPIWVDEIPLASTTSPTPTTSEGTTISPSQWKTEFSSPEAQVVRDAIGAVMICLKNPVYNPSLGANEGVDVDVEDRPEVRSLKDFVQAVGDVRALIEEERGLGEVPGLVVLVGEEAGGSSANGNGKGEEEEGMEELEIDEPFSVGWWEDQVCEMGLMGMEVVRWDGSGKGEDEGRNRYGELQGMRRIKEVLETHDWAATEDGEPGLLDDGFDDELERELLGLDDETETGFGLEVDELQREMVGLRMAIERGGGDGFDDGDEEDEELRVDAVEALLLRMRAIKDMSDELPETERKRFAAKAVRDIMKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WME0</accession>
    <name>A0A317WME0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD-superfamily phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_71668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467433.1">
        <property type="nucleotide sequence ID" value="XM_025617620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WME0"/>
    <dbReference type="STRING" id="1450535.A0A317WME0"/>
    <dbReference type="GeneID" id="37119763"/>
    <dbReference type="OrthoDB" id="198652at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25841" checksum="FB4F9DA32F00D73C" modified="2018-10-10" version="1">MQPPNSNLRAFNLAVTTLLKSPSQFLPHLTIPTITHLPENLGPAIHPNVSEKKPPTIRALVLDKDNTLCHPKTTAFPSEILAKLTALRTSATSPFNKENSILIVSNRAGSHPRYDEEVRELEETLGELKIPVFRLPEGSEKKPFCGNEVLEWFRERGVVTRPDEIAVVGDRLGTDVLMAVAMGSWSVWCRDGVTEGGREMNLLEKMEAWVEKYLRESRGLRAPPPKGWESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN44</accession>
    <name>A0A317WN44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_556322</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467622.1">
        <property type="nucleotide sequence ID" value="XM_025613857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN44"/>
    <dbReference type="STRING" id="1450535.A0A317WN44"/>
    <dbReference type="GeneID" id="37116000"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="8">
        <location>
            <begin position="98"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="538"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY87839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="573" mass="65402" checksum="69CFF97B6A03B54F" modified="2018-10-10" version="1">MYRPPSTRLWCSIQTTTPILKQHCRSISKASTLSYPDHPNNIPSQTNWNSNDDFFKFTRGRFLVSEAENLRAREIRFDMNQLARVAAESIGATQCISITKYPDGMFNKAFLMTMDDGREVVAKVPNPNAGVPYFTTASEVATMDFARTVLDTPAPRVYSWNLRAESHPVGAEFIIMEKSEGVPLSQVWDTLKLPQKLQVLLAMTRLQKQWLSVSFSHYGGLYYVRDVQISPGNHYVKDGKVVYDSKFAIGPATGRDWFDADRSTLDIEREPWTSLKQYLQAIGTRETKAIQSLNPPKQIALFCGPKLYQPDTEKKLAALAWYQQIVDTLIPKDTAIINPRLWHNDLHDDNIFVDPHNPEKITGIIDWQSCHISPLFNHNPDPAFLHWDGLEPETLDLVPRPNLSGLSPEERSAAVLEYTIQNVFIGWRKLMHAKNPDLYQIVNFRKTPAYGLIFVAHRMFEYGEAHFQSLLVDLEDTWADLPAVTSDVPFPYQFSEADIERIRSDSDGAVAGTDLVAEVKEQLGDLWPDKGLIEHEQYEDCKAALNEIKAQILEQLAETDEEKAEYERYWPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN88</accession>
    <name>A0A317WN88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_58545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467702.1">
        <property type="nucleotide sequence ID" value="XM_025615694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN88"/>
    <dbReference type="STRING" id="1450535.A0A317WN88"/>
    <dbReference type="GeneID" id="37117837"/>
    <dbReference type="OrthoDB" id="444127at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="550" mass="60659" checksum="7B32F5C06471B3EC" modified="2018-10-10" version="1">MSSFEPSICSSERLFPNPETSSERIAALSLLDAITVNFLDTCAVWLFERPHLQTQFDLVDHLRQSLRVTLDAYPQWCGLVKIINTVDGPPATGEDHLAPHARRFGRVYAHHGTRSDPGVAFVAARSTATLDELHPSSRPTSQALWNQEKVSLSQFVPKTQLVNPAKVSDADIIPPIMAIQVTELACGGFALAVKIAHTLADASALVYFVKDWASVSRSVLLGEATPVLSPVFDPERLDNAAAGDINAVTPDESIIQQTKSLPFHRYDWWNVPADSPLKMRIPEVFRNQELPPAGKQIPWPEWDTKAPVSHYIVHLSRDQVEAIWKQTSNASSADTNDSRLSRHDAVLAHIWASINRARNMHNDPGPVHCDLTYGCRPAFQLGDAFMGSLAVMVNVEMAGADVTTTANSDGKQSAVLPPIAQRIRQTLSQVRDPALLAAHLHSLAYEKSPQRIWQGFLGSRHVMTTTWARAGLYEVDFGLGPQPTARYADGILANLDGLVLIKEAPPDRTSDVNDEALPTWTDHGVDVQLHLQTEDMERLLLDPLLFPNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNB6</accession>
    <name>A0A317WNB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alcohol dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_586287</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466747.1">
        <property type="nucleotide sequence ID" value="XM_025615754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNB6"/>
    <dbReference type="STRING" id="1450535.A0A317WNB6"/>
    <dbReference type="GeneID" id="37117897"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08297">
        <property type="entry name" value="CAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000002">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF3">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="16"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY85730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="350" mass="37135" checksum="0960DC7907736E99" modified="2018-10-10" version="1">MTIPEIQWAQVVEQKGGPPVYKQIPVGKPGPDEILVKIRYTGVCHTDLHAMKGDWPLPVKLPLVGGHEGAGVVVAKGDLVTGFEIGDHAGIKWLNGSCLSCEFCKQADEPLCPHASLSGYTVDGTFQQYAVAKASHASNLPKEVPLDAIAPILCAGITVYKGLKESGVRPGQTVAIVGAGGGLGSLALQYAKAMGLRTISIDGGEEKKAMCEKLGSEAYIDFRTSNDVVADVKAATPEGLGAHAVILLAVAEKPFQQATEYVRSRGTVVAIGMPAGAYLRSPVFNTVVRMINIKGSYVGNRQDGVEAVDFFARGLINAPFKTAPLEELPRIFELMEQGQIAGRYVLEVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNF2</accession>
    <name>A0A317WNF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_535627</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat MORG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467059.1">
        <property type="nucleotide sequence ID" value="XM_025611836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNF2"/>
    <dbReference type="STRING" id="1450535.A0A317WNF2"/>
    <dbReference type="GeneID" id="37113979"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051980">
        <property type="entry name" value="WD_repeat_MORG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842:SF3">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING PROTEIN 83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22842">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="15"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY86468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="35683" checksum="ABF4FE562CB976FB" modified="2018-10-10" version="1">MPAIKQFPTRLVHTLKTHNGPVNAVTFSSDPGVYVLTGSTDRAIHLTRAISNNNNAETTSPIQKYEAHGYAVLDVAVAADNSRFSSVGGDRQVFLWDVEQGGTIRRWSGHNARVEAVQFAGESDSVVVSGSADTTINIWDTKSNSHKPIQTLTEARDTVSSLHVHMPTYSIASGGYDGRVRVYDIRMGRTIVDVLAHPVTSVRCSNDGNALLASTTDGRIRMLDRSDGKLLKAFGGEDVSASQSNATYRKSDLRIRSVFAKADAVVLSGSEADNSGNDNGSRQASVFAWDVLSGEMIACVPTGEGVKAVSAVSWNEKGGSWAAGCSDGTVKVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNF3</accession>
    <name>A0A317WNF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_535005</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467777.1">
        <property type="nucleotide sequence ID" value="XM_025611674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNF3"/>
    <dbReference type="STRING" id="1450535.A0A317WNF3"/>
    <dbReference type="GeneID" id="37113817"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000022">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="137"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="255"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="12">
        <location>
            <begin position="349"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="14">
        <location>
            <begin position="622"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="13">
        <location>
            <begin position="839"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY87994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1212" mass="135970" checksum="F955C3F41365F6C1" modified="2018-10-10" version="1">MQSSPNMLTKFESKSSRAKGIAFHPKRPWILVSLHSSTIQLWDYRMGTLIDRFEEHDGPVRGIDFHPTQPLFVSGGDDYKIKVWNYQTRRCMFTLNGHLDYVRTVFFHHELPWILSCSDDQTIRIWNWQNRSLICTMTGHNHYVMCAQFHPTEDLIASASLDQSVRIWDISGLRKKHSAPTSMSFEDQMARANPAQADMFGNTDAVVKFVLEGHDRGVNWVSFHPTLPLIVSAGDDRLIKLWRMSDTKAWEVDTCRGHFQNASACLFHPHQDLILSVGEDKTIRCWDLNKRTSVQSFKRDMDRFWVIAAHPEINLFAAGHDTGVMVFKLERERPASAIHQNQLFYITKEKHVKSYDFTKNIETPPMLSLRKLGSPWVPPRTLSYNPAERAILVTSPTDSGTYELIHLPRDATGAVEPTDVKRGQGSSAVFVARNRFAVFSQGNQQVDIKDLSNSTTKSIKPPAGTTDIYFGGTGCLLFITPTTVVLFDIQQKKQLAELAVSGVKYVVWSNDGLYAALLSKHNVTIVTKSLEQVSSLHETIRIKSAAWDDAGVLLYSTLNHVKYSLLNGDNGIIRTLDQTVYLVKVKGRNVYCLDRNAKPRVLEIDPTEYRFKLALVKRNYDEMLQIIKTSSLVGQSIISYLQKKGYPEIALQFVQDPQTRFELALECGNLEVAIEMARELDRPNLWSRLGAEALAHGNHQTVEMAYQKQRNFDKLSFLYLSTGDQEKLARMAKIAEHRGDFTSRFQNAIYRGDVEDRIQMFKEVDLYPLAYLTAKSHGLTEEAESILEACGLTEDQITLPTVDEPARVPHPIAPTFKSNWPVKAAGHSSFEKALLGEVGAGDEEVAAIEFEPEEEGDAVTARDTLEDEEEDVAGWDMGDEINVEEDVDFVNVDSAEAGAGSTEADLWARNSPLAADHVAAGSFETAMQLLNRQVGAVNFAPLKPRFLEVYKASKTYLPATTGLPPLVNYVRRTVDETDSRKVLPIIPKDLETIANVDLQEGYAAMRANKLEDGVKIFRGILNAILINTVSSEAEVEQAKKIIDTAREYILAMSIELERRSIPTDTPDNLKRSLELSAYFTIPKLEVAHRQLALMAAMKLAFANKNYSSALSFANRMLANGGAVKLLEQARKIKAQCERSPQDKIDIGFDQFAEFDICAASYTPIYHGSPSVSDPFTGAKYHEQYKGTVCRISEVTEIGAPASGLRLFVPGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPU6</accession>
    <name>A0A317WPU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL28m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_535405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467500.1">
        <property type="nucleotide sequence ID" value="XM_025611775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPU6"/>
    <dbReference type="STRING" id="1450535.A0A317WPU6"/>
    <dbReference type="GeneID" id="37113918"/>
    <dbReference type="OrthoDB" id="361870at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.40:FF:000003">
        <property type="entry name" value="54S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="entry name" value="Ribosomal protein L28/L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_bL28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribosomal_bL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="Ribosomal_bL28/bL31-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribosomal_bL28_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13528:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL28M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="L28p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY87292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="212" mass="24622" checksum="9FC26B18C5F515FD" modified="2018-10-10" version="1">MAGLQTRSAMSLPFSLSAAFRNLSLTTPKRSFSTTLAAQKTRQLPDYIPPYPYGPNYVFKQANSGLYAGTMIRFGNKISQGRNEGKTRRSWKPNVRRKKLYSEALGEDLFIKVTRKALRTIRKSGGLDNYLLSDRPGRIRELGIFGWELRWKVMQTPKIQEQFRLERKKLGLPEPPTFEEWVQQKEAEIKAQVEEETNIREITKPTYNEKQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQC7</accession>
    <name>A0A317WQC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_534495</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467968.1">
        <property type="nucleotide sequence ID" value="XM_025611566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQC7"/>
    <dbReference type="STRING" id="1450535.A0A317WQC7"/>
    <dbReference type="GeneID" id="37113709"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY88606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="320" mass="33140" checksum="6297AA5B292A7DEC" modified="2018-10-10" version="1">MGFGAPRGGGRGAPRGGRGAPRGGGGRGGGFGGGRGGLGARGGGRGGGRGGPRGGGGRGAPRGRGGRGGGRGGAGAKGGAKVIIEPHRHAGVFVARGGKEDLLVTKNLTPGEAVYGEKRIAVEGPAGEDGAVTKTEYRVWNPFRSKLAAGILGGLDDIYMRPGSKVLYLGSASGTSVSHVADIVGPTGNVYAVEFSHRSGRDLIGMATHRTNVIPIVEDARHPLRYRMLIPMVDVIFADVAQPDQARIVGLNAHMFLKEGGGVIVSVKANCIDSTAKPEVVFAREVQKMREERIKPREQLTLEPFERDHCIVSGIYKRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WS89</accession>
    <name>A0A317WS89_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_516391</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467780.1">
        <property type="nucleotide sequence ID" value="XM_025609960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WS89"/>
    <dbReference type="STRING" id="1450535.A0A317WS89"/>
    <dbReference type="GeneID" id="37112103"/>
    <dbReference type="OrthoDB" id="425936at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027372">
        <property type="entry name" value="Phytase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957">
        <property type="entry name" value="BLR7070 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37957:SF1">
        <property type="entry name" value="PHYTASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13449">
        <property type="entry name" value="Phytase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016320418" description="Phytase-like domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Phytase-like" evidence="3">
        <location>
            <begin position="80"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY87997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="508" mass="55508" checksum="68E295E54AB4C0FA" modified="2018-10-10" version="1">MRLHSLLATLPFTAAALTSSNIVNQTTCGNTTYTYVGLEGYGFVPSNATDKYGDTMGGFGSSAAFDLATWRRTGLNSYTGILYTLPDRGWNTNGTLNFQPRIHTFNLTLHLAPNASSSHPSPPNIHLHYLDTLLLTGPDNQPLTGLDASFTGTSSYPNLPPLPIAVYTGDGFGGPGPGGHRIPLDSEGLALPAHDPSHIWICDEYGPYIYKFNKHTGQMVQAIQPPPAYLPRRNSTLSFSADSPPIYNPSLTPSPADPDPGRDNNQGFEALTISPDGRKLYTLLQSALNQEGGLKKTSRNQARLLQYDISSGINATYEHSYVVTLPKYHNPTKDEKVVAAQSEIHLLPTGDFLILARDSGFGHGQSNSLSVYRHADIFHIGSNTTDLKSLTGVDSPNGTIASKKGTLNPGITAAEYCPFLDYNIEDQLARFGLHNGGPQDQWLLNEKWESLALVPVDPDSDSTEYFVFSISDNDFITQDGYMNFGRFRYADASGYNLDNQVLVFRIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WS91</accession>
    <name>A0A317WS91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside-diphosphate-sugar epimerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_491529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468267.1">
        <property type="nucleotide sequence ID" value="XM_025609156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WS91"/>
    <dbReference type="STRING" id="1450535.A0A317WS91"/>
    <dbReference type="GeneID" id="37111299"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY88905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="301" mass="33624" checksum="CA9C7D2D6B50AA3F" modified="2018-10-10" version="1">MTAVLITGATGNQGGALIRSLVSRKAPFEILAVTRNPTSASAQRLSQLSSNIRLVQGDLDSPSAIFDNARRVTKSPIWGVYSVQAAIGNASAEESQGKALIDESLKQDVKFFVYSSVDRGGEERSFTTPTKIPHFIKKHNIEHHLVDRTKGTAMEWTILRPTAFFENLTADFFGKVFATSFDMALKGSPLQMVAASDIGYFGAEAFLHPEQYRGRGVSLAGDEITHTQMAKIFQQQTGQPFPKTFRPLCSLFLASMKDMGYMFKWFHDEGYRADIASLRLKHPDLKNFETWLAQESDFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSA4</accession>
    <name>A0A317WSA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_546168</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467800.1">
        <property type="nucleotide sequence ID" value="XM_025613281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSA4"/>
    <dbReference type="STRING" id="1450535.A0A317WSA4"/>
    <dbReference type="GeneID" id="37115424"/>
    <dbReference type="OrthoDB" id="9368434at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="511"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="613"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="625"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY88017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="750" mass="83763" checksum="BCB136C59D763B71" modified="2018-10-10" version="1">MITSQKPEAVKSQHPRRGRVMSSRPPSLLSPTDAHASSHPRFRLRKEETFHATSPSSDDEDILADLHPLPRRSPTSPAALQAIIAGQERMTKMLSRFDLRSPRKPLSREDDDELPVRKGVLEIHLRRSQSGRGDSFNMDVDKDQRSPRKEAPTKARKVHCHPSDSGLGTSVSSCQTTSSRQVKEGQLSQDNSITNSQAQSAITSSIMAIEPEATPKQKLSLGACLEIEKRILGPLLGQDMIKPFHHIVESARRQIANEQIGTLRDLEKALLYVAADVESEVGSYYQFCSSTILCLHETYTYLNPRDLCMPSDKSYSNSYFLDLTAQVHRFKAMRDEARKNKKDAPEAKLILKGGMSETGRPLELVAQKDGEAVSMQTGKPYDAHAPPLVKRTLSLGEADEGARRSMARRKKNAPPMNINTKCSHCDKIFQRPCDLTKHEKTHSRPFKCPFEGCKYHELGWPTEKENERHINDRHSTTPRMYACTFNGCAYKSKRESNCKQHMEKAHGWNYVRAKNNGRNAKRRATSARASPAEESTAHSSPLHMGPDPVSSIQLAPAQVASLQMASDQISPLQMSSDQVSLLQMHPDHMSPLQLSLDHMSPLQMTPDRASPAEMHSLQMSPDQGSSVQLSPPQVSPAQLSTPATGPLQSPTGFVNYPQTQMFQLQDPYTQLKNEDCVLYTDNDFAPYNGSTEFFEDASFGYGEHLYQTGQMDISSMGALCDDPFMNNMLWDNTFPDENLYAINQPPMGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSK9</accession>
    <name>A0A317WSK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_623402</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468297.1">
        <property type="nucleotide sequence ID" value="XM_025617149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSK9"/>
    <dbReference type="STRING" id="1450535.A0A317WSK9"/>
    <dbReference type="GeneID" id="37119292"/>
    <dbReference type="OrthoDB" id="7813104at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042719">
        <property type="term" value="C:mitochondrial intermembrane space chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.810:FF:000001">
        <property type="entry name" value="mitochondrial import inner membrane translocase subunit TIM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="15">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY89386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="96" mass="10448" checksum="B6B6F02C0B678C9D" modified="2018-10-10" version="1">MSFFGSGSGSDPSSKEVKDALVKQVQAESAMANARSLITKVNENCFSKCIPTPGASLSAGEQTCLTDCMEKYIAFWNEVSRTHHNRMGLESKRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSM0</accession>
    <name>A0A317WSM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_584713</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468365.1">
        <property type="nucleotide sequence ID" value="XM_025615646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSM0"/>
    <dbReference type="STRING" id="1450535.A0A317WSM0"/>
    <dbReference type="GeneID" id="37117789"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF13">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="420"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY89454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="580" mass="64074" checksum="14D145D4E299B5D7" modified="2018-10-10" version="1">MALGASDQFDVVIIGAGPAGLMAAVWMAQTGVKTLVIEEKPRRTLTGHADGLESRTFEILNSFGLGESIWMESNRTVDVCLWSSSACGLQRKSVSPNYNPGWSRFQEATLCQGRIEKYLLNFVKRHGHMKIEWATVPTSLELSKDHTETPGVYPIGLKINSFSTKTGEQPRKTKIEPDRTVQARYLIGCDGAHSWVRKQLGLALEGDRTPDGHWGVIDCIPITDFPDIRKRCIIKSDGGNLMIIPREKKLVRFYIQISPTVAAGFKANYCPSALMTVLKNILQPYTFDTSHTEWSTIYTVGQKLCNTFSVKNRVFLAGDAVHTHSPKAGQGMNVSMQDTYNLGWKLSSVLKGVAPPEILCTYQAERLPVAKRLIAFDRKMCSGICSATGEEYPDSSSDRFSDLKSTLSEENTCASGLGVVYGPGLLVTSTNNQEFNPCADGTHLCCAHSKPHLARNIIVGGRLPSQPVLCQSDSRPWNLQDRLVSTGQWHLVIFGGNITDLTQMTRVKRLTDSFSHPESLINRMGLTDGSPVGSVATYMVHSAPREEVEFMDLPPILRPFDNVTGYDYSRVFADNKSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSM3</accession>
    <name>A0A317WSM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_70020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467408.1">
        <property type="nucleotide sequence ID" value="XM_025617606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSM3"/>
    <dbReference type="GeneID" id="37119749"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17196" checksum="BC2F5924BE39151D" modified="2018-10-10" version="1">MIGMIGTGEGESLVGMCSRRCRGEEAAMTDWQGSDGRHLIPGHTLRAVCLLCSRRQLVASSLQSIQFVPSFVSLPIQGASSSLPKVFLETQTADRAHLICHANFTAPPPASSKKCSIKCLEIRHAVTFFSDSQLHERKSSAQRQESALGPESWAQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTQ6</accession>
    <name>A0A317WTQ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_46999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468024.1">
        <property type="nucleotide sequence ID" value="XM_025608311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTQ6"/>
    <dbReference type="STRING" id="1450535.A0A317WTQ6"/>
    <dbReference type="GeneID" id="37110454"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000649">
        <property type="entry name" value="Compass component swd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000614">
        <property type="entry name" value="WD domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037850">
        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="63"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="483" mass="53991" checksum="09726AE40DB02BE6" modified="2018-10-10" version="1">MNLSLVDPFVLAQDYPDTLTEKLRSGHATCLRFNRKGDYLASGRVDGTVVIFDVETNGVARKLRGHTRQIQSLSWSRDGRYLLSSSQDWKCILWDLKDGSRVRTVRFEAPVYIAELHPYNHLLFVASLFEDQPILVDVSLPKPVKRILPSAPFRPPPPKNEEIDPAVAAKQAAQDAKHSTCVTVFTALGNHIIAGTSKGWINIIETQTCTTIHSTRLCNGVVILLRLASNGRDLLVNSSDRVIRTILMPDLSQLGIDLEPTNIKLQVEHKFQDVVNRLSWNHVAFSSTGEFVTASTFMNPDIYVWERSHGSLVKILEGPREELGVVEWHPCRPMVVACGLESGCIYTWSIVTPQKWSALAPDFGEVEENVEYVEREDEFDIHPAEEIHQRRLDQEDEVPDVLTIEPHKDGAEEDIVTSFRMPVLLDISDSESEDDIVAVGPGTMRRRSPGAGRDRANANGDGEKDSTTGGRNGTTRAQKGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUG7</accession>
    <name>A0A317WUG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_556364</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467673.1">
        <property type="nucleotide sequence ID" value="XM_025613860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUG7"/>
    <dbReference type="STRING" id="1450535.A0A317WUG7"/>
    <dbReference type="GeneID" id="37116003"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000606">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000758">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF127">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="171"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="375"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="428"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="517"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="581"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="540"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY87890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="653" mass="70687" checksum="AA4FF8F0F7CF6B07" modified="2018-10-10" version="1">MSSFLPVNNISSPPDRVMEEATTSSTPRPHPKAGSVSQDTIQSLGAAHDESTPRNISIDDSHHADSQGSASLTSEDPMHGESDEGSDHEAETKGGAPPSKKKKGQRFYCTDFPPCNLSFTRSEHLARHIRKHTGERPFQCHCSRRFSRLDNLRQHAQTVHVNEEIPGDSLAATGTRFQRQIRTDRVRPQGRARAGTAGSQGTHSRGHSRNLSASSITSTASTFSQPQELRRRPAPLMMANDRARLMEQMDAPSTPPARGLPGPTAGGSPYTPSHHVFSAGGNGSPHVASPISTASQASGFWEGKTAARRLSVPTGANPFASQHVNVYPPGYVATQAYAPHGSVYASPVNSTYSLARDETSHSATDTDLRRRTWHPSTWSAVPRPATSGLSNYQTPEVFKPSFSNGSTEQPPRLPGIESFDKVVAQRPLTPPVRRSSPMQIDNPNKPPPNYNFGGGFNYTQPAKRPAPPISGPGHRRGHVSWDMSLHTNLTGLHIRDKPAQRDASNWSQQTIAELHNVGSRPSSSYQQQFQEYRGHGHAPSYSNATSSSQATRTSPEDSSSSEGVHTPSTASLEYHPAIVHNNGYVEPHHPPFSSDTSHAACPPLPPQSDSYHGKHDPRTEFLPHSAREPGMGRLEALVAVATSENKGAAKLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUI1</accession>
    <name>A0A317WUI1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_623910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468209.1">
        <property type="nucleotide sequence ID" value="XM_025617182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUI1"/>
    <dbReference type="GeneID" id="37119325"/>
    <dbReference type="OrthoDB" id="4507040at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016404244" description="WAP domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="13697" checksum="F2BC29FEEA0616BC" modified="2018-10-10" version="1">MHLQKSLTFIIPLLPLTHTQSTLTTTTTTPCGPIPSCPTKHFCTTATFYTPTTTYITTCVPTPTCLTVYANCISGGGGPACCSGYCAATKCRSTDPDWPGCSEDEGVCRDDGDCCYGNECVDGLCERET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVX2</accession>
    <name>A0A317WVX2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor CWC24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_565271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CWC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468363.1">
        <property type="nucleotide sequence ID" value="XM_025614485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVX2"/>
    <dbReference type="STRING" id="1450535.A0A317WVX2"/>
    <dbReference type="GeneID" id="37116628"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000045">
        <property type="entry name" value="RING finger protein 113A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 7 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 7 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="254"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY89452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="339" mass="37553" checksum="2E13F32E8640F793" modified="2018-10-10" version="1">MTETTNDTAAAADPQPPVITFKKRGAKASQNIRKRPAAPATSQDDDSSDFSSSEDESGHRIKRRKNKGAGIVSASSANTKPVVREPAATATGDRKVQIADTNDATKHVDWFDEDAKNGRSSKPQDASNDLQMPDGTYKGLANQTSFIKKNPNAPNRSFGPIKAATNIRTITVTDYSPDVCKDYKQTGFCGFGDNCKFLHDRSDYKQGWELDREWENVTKGKQLKGTVVASADRTRVENKDDDEESMLEDIPFACFICKGPYREPIVTKCGHYFCEQCALQRYRKDPSCAACGSATNGLFSTAKRLKKLLDRKRELAAKRRQEAIEAGEEVSDEEDEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVZ3</accession>
    <name>A0A317WVZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TIGR02453 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_463069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468891.1">
        <property type="nucleotide sequence ID" value="XM_025608005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVZ3"/>
    <dbReference type="STRING" id="1450535.A0A317WVZ3"/>
    <dbReference type="GeneID" id="37110148"/>
    <dbReference type="OrthoDB" id="2537769at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02453">
        <property type="entry name" value="TIGR02453 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="CHROMOSOME 12, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452:SF1">
        <property type="entry name" value="DUF2461 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48247" checksum="6A5AD0126DC33799" modified="2018-10-10" version="1">MPRRSSRAVPASAAAPVSAPKRRASDRISEASRTGPKKQKYDNTTAKKATKSTAKKSQYFQEEASEESKPSAPKTASHDNPDTSFPASPGASAEVSDATPPKTGLTRPRKPEQAPKRGQKNSQEEEEPSKPAQRRKGGIKANTAASTGGKELWREGVTTGLGPGKEIFIAKPKARDPGSVAYQENALHPNTMLFLQDLNEHNEREWLKAHDADYRASKKDWETFVETLTEEIIEKDGTVPELPVKDLVFRIHRDIRFSKDPTPYKTHFSAAWSRTGKKGPYAAYYVHCQPGSCFVGSGLWMPQADKLALLREDIDRNSHRLKAVLREKEIRREIFDGIADDEEIAVTAFVNHNKESALKTKPKGYDLDNENIQLLRLRSFTIGRPLSDEELLSPNAQERIAALIGIMEPFVTYLNSVVMPDPAQEESGSASEADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW73</accession>
    <name>A0A317WW73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_565171</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468987.1">
        <property type="nucleotide sequence ID" value="XM_025614477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW73"/>
    <dbReference type="STRING" id="1450535.A0A317WW73"/>
    <dbReference type="GeneID" id="37116620"/>
    <dbReference type="OrthoDB" id="10257085at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF4">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="52"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY90609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="202" mass="21973" checksum="EFFFA274E8B0165F" modified="2018-10-10" version="1">MTISLPSNVHTPQNETFTSLLSQLRQRTLKPSQVRSLIRDMTATITKSLHIETTETETVAVIVVLRSGLSMFDGFMDNIPADVNTAVYHMGIFRDEASLQPVEYYNKLPLKPAHIKQAYILDPLIATGGTAAAVVSILQDWGVEKVTFLSMLSTPVGLGHAAAVWPEGSRFVVGAVDPEVDEKGYIQPGVGDIGDRLYGTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWC7</accession>
    <name>A0A317WWC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_45508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467972.1">
        <property type="nucleotide sequence ID" value="XM_025607632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWC7"/>
    <dbReference type="STRING" id="1450535.A0A317WWC7"/>
    <dbReference type="GeneID" id="37109775"/>
    <dbReference type="OrthoDB" id="5392716at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46177:SF1">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="1">
        <location>
            <begin position="5"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="178" mass="20407" checksum="2BE35398E1D6F157" modified="2018-10-10" version="1">MPRSIDLEPFKPEIISLFHNNTTAAGIASHLQQTHHLQVRERTIKARLSAWGISKRNRTATSNTQLHTRISELFINQCLEERELLQVLQSEGFEISSRTLRRIRTRLGLVRRTNDPVQRQMQEDEALKYLREESKKGTIKGYGRGLLTSHMRGQGIIIARDRLYNLYRTIPGGSSGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WXG0</accession>
    <name>A0A317WXG0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_31064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468959.1">
        <property type="nucleotide sequence ID" value="XM_025606821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WXG0"/>
    <dbReference type="STRING" id="1450535.A0A317WXG0"/>
    <dbReference type="GeneID" id="37108964"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="409" mass="44552" checksum="AD7E95880298CAF4" modified="2018-10-10" version="1">MPLIRKSYTIAWISPLEVELTAAYLMLDEEHPPLAQPLGDPNHYTLGRIATHNIVIVNLPITGNTSTAAAVAHMRRTFPSVRFGVLVGIGGGVPAVTDKGRIHLGDVVVGKPDMGTPGVVEYANFQEWSDGWSSYAKCGSLLLPPAELLEGVQVVERKRARLRVDPVREHLRRIDTTIRGLRRYDFPGRSQDFLYATGYHHEVPGLSCLEAGCDLRVRCLDDSDALGDEDDGNDPIITVHTGIIGSGPKLIKDGVVRDRLAQRHGIVCFETEAAGAMHGFPCLVIRGISDYCDSRKNNVWHGYAAAVAAAYARELLCNVPGRGGRRKANVKDNAKPDINHAVPCYVLPLVVIPGQTAVSVFDNYLPGNGAWRLGLRAARRHGIPNPRNVTHGEDLRPRPPSGKPPGRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WXR9</accession>
    <name>A0A317WXR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_574537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468499.1">
        <property type="nucleotide sequence ID" value="XM_025615025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WXR9"/>
    <dbReference type="STRING" id="1450535.A0A317WXR9"/>
    <dbReference type="GeneID" id="37117168"/>
    <dbReference type="OrthoDB" id="5404940at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="661"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="699" mass="76601" checksum="F737C6C1B47081B1" modified="2018-10-10" version="1">MGNNNTPPFLYDSPPSNRFYGQFDPSFNPKAVTQASWARPAPKPEVKGPLVDLNSHDLGNTSDSKPKWTPMSPKTKGRVVYGRKVQLGLRVFALVGALGSLFCSIVIKNAAATAIWIVRVGPAVAILHTLYGIYHLSRSSITRPPGSQASYMLFAVTFDLGLVPFYVFAAYLGYRQYSDNAYDWTTMLGSDIDVTTKIAEATFLLGIINGALHAISLGISLFLGNILRKITKLPPDMNPLEDNLTARPLKRTKSEILEKHASKSTLGSDNISSEDPLIGVPRNVPFIDTRSNSSFNNDYSRFPSGFTDRTHPQHAPSFHRPPRVETIPHLPFHQPNDIADDITISSPIENPDIFTRPTTTIPYGSPVREPSPDLPNRSQCVSPASDNWIVYPSRSATPVDEVQDEHPAPRDPSSVYSRAETAGSSKGGVMDWLSPQRYGLNMRGAITENAHGEYESVAANEYYGNDDEAHDILYRGFYANAEQDLGDHPIDIFQDHEDLDEDTLNSLRVNPLALNPPSPQPKPDQIRNRTPSNGRMALTDIPNLSPKPPAEEPLLDSIRKKASFYGVLNTSGLDTPRKASRDEPKPSSKKSKMTIRKGQKFNAYGALKQHDDGDLNGLDVPYADPVGDRKGRVVSNSGADASHANSSLSYGNYISGLGAGRRRDVSGKMAEEGRVEVSKPQNENTTPIRAAGWARFAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYI7</accession>
    <name>A0A317WYI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_462542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469192.1">
        <property type="nucleotide sequence ID" value="XM_025607978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYI7"/>
    <dbReference type="STRING" id="1450535.A0A317WYI7"/>
    <dbReference type="GeneID" id="37110121"/>
    <dbReference type="OrthoDB" id="2104739at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="149" mass="17005" checksum="21105F328386E7A8" modified="2018-10-10" version="1">MFNPTAIPLISGNDIDRPMNALTLTQNLHTLFGRFEITFKYIGPHTYKIDYVKQDRLLQIVKLPVTRTLYLTPDRNIDPPSVDLLKIHHTIAKILHLSAAGEFIDKFLRDMEEMEGGQVMSNGTSRIDEYVRFKLAGCLDGCFEEMSVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYV1</accession>
    <name>A0A317WYV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_513780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469277.1">
        <property type="nucleotide sequence ID" value="XM_025609855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYV1"/>
    <dbReference type="STRING" id="1450535.A0A317WYV1"/>
    <dbReference type="GeneID" id="37111998"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="35237" checksum="B41DB92DDB7C26B5" modified="2018-10-10" version="1">MSNPYPIRSPLDPNGDESKKDYSYTNPLSSSGSDFPCKGYAKDPFRSVATYSPGGEYDLELQGSATHEGGSCQVSLSYDQGDNFQVIHSMLGGCPLTESYKFTIPSDAPTGDALLTWTWFNKVGNREMYMNCAQVTIGDSDDSHSAKQKRDSFSSLPPIFIANVNGPGQCTTTEGDDVNFPLPGPSVEGSVSGTGYNCTGTAPFLGSGSSGSGSSSSSSSGSSHSAASSSSTGHSTTSTTSKSTSSTTKTGTKAATPASSSANAPAMVASSFGSQSARLMSHPTAVSADGTERFTPGKPCVDGAIICGPQGTSWSMCSNGRPVHMGAVAAGTYCEHGEIHALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X072</accession>
    <name>A0A317X072_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid adenylation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_622510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469403.1">
        <property type="nucleotide sequence ID" value="XM_025617084.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X072"/>
    <dbReference type="GeneID" id="37119227"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="1053"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2579"/>
            <end position="2655"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="4692"/>
            <end position="4765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="5238" mass="576370" checksum="A455C9780C8EAC87" modified="2018-10-10" version="1">[encoded data, 5238 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X087</accession>
    <name>A0A317X087_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_584191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469309.1">
        <property type="nucleotide sequence ID" value="XM_025615608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X087"/>
    <dbReference type="STRING" id="1450535.A0A317X087"/>
    <dbReference type="GeneID" id="37117751"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17052" checksum="5169E1018E4F67AB" modified="2018-10-10" version="1">MSPGHDADKYGRPLTGNSKSELDTMAIVEVKKRIRDRASQQILMQEACEVCGWLMKTSADMTIFNGHFLLVSQNRHEIYITFAQYKRSLEDYLNRGIQTDEFLVMETYGPWFAEDAESLRHFAQVIVTAVLIAKAARLSRQSMPPPPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1S0</accession>
    <name>A0A317X1S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_462095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469280.1">
        <property type="nucleotide sequence ID" value="XM_025607959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1S0"/>
    <dbReference type="STRING" id="1450535.A0A317X1S0"/>
    <dbReference type="GeneID" id="37110102"/>
    <dbReference type="OrthoDB" id="10260946at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000789">
        <property type="entry name" value="Transcription factor (SPT8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000927">
        <property type="entry name" value="Transcription factor (SPT8), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057544">
        <property type="entry name" value="Beta-prop_SPT8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23798">
        <property type="entry name" value="Beta-prop_SPT8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="103"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor spt8 beta-propeller" evidence="5">
        <location>
            <begin position="469"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="280"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY91552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="638" mass="68252" checksum="814FA2B037877208" modified="2018-10-10" version="1">MVEDDDDRDLAGSPDGSSDNEMDDTLRNADDGDHDNEPDADADADQDAESQSNVSHISESAGGVTQPNPVVEMSTATATNALSDPLAAFHPRVRAECLTAPTFDIVPTTAAPHSTSINAVTATADMRWVFSGGSDGYVRKFNWVDSINSKLMLTVAQRHPFVDSVIKAGVLMTYWENMDGNALSPVYSLASHSEGLWLLSGLESGSIRLQSVRHDEGKEIALLQQHTSAVSVLSLTSDEKSLLSGSWDKRVFDWDLNTGQIRRAFGSSARQISAIEVRPESSLAVPRDTTEFQQPNGTYSSNYSAPANDSFGFMDTTNDGENGAGSNPQAGSPADSLFGGADSLFGDENANGGEDAGAPENAFGIDEDDEFGKALTNGVMPDVDAPGEPEPSQPAVAEPPAASMPSTVAAGEAANSNAATQPPDSGEGEMLHGFSQPVVNGGPHAEELERPIYTQDSALPTHNESGAATDNLFLAASIDGTIRVWDRREPEAVARITPQNCPPWCMNACWSPDGNYIYAGRRNGTVEEYSLHKGLRNPQRTFKFPQGSGPVTALKAMPNGRHIVCASHDILRLYDLKHEQVTRHSTVPFLIIPGHRTGTVSQLYIDQACRFMVSTSGNRGWEGNTTEVLLGYEIGVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X217</accession>
    <name>A0A317X217_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_623022</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469325.1">
        <property type="nucleotide sequence ID" value="XM_025617119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X217"/>
    <dbReference type="STRING" id="1450535.A0A317X217"/>
    <dbReference type="GeneID" id="37119262"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF1">
        <property type="entry name" value="TRANSPORTER_MALIC ACID TRANSPORT PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY91597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22554" checksum="BE7B36242A7811E6" modified="2018-10-10" version="1">MISLFILAEYFYNLHHHGLPPMRRRPQMFIAIGPPAFTAVALMGMAEIATEKFPSYYIPLAAHVNTAEVLLILTIFLSIFMWIFSFFLWMLGWLSIFAACHEWKFDITWWATVFPNTGFALATIKIGDLLASEPIRWVGSAATIIQVALWLGCFSLHVWAYFTRRVLWPGMDEGFGAETHLGRGLDLEGNVVSSKSSCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3C2</accession>
    <name>A0A317X3C2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative carbonyl reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_615840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469824.1">
        <property type="nucleotide sequence ID" value="XM_025616775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3C2"/>
    <dbReference type="STRING" id="1450535.A0A317X3C2"/>
    <dbReference type="GeneID" id="37118918"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF252">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="328" mass="36380" checksum="0238671130A186C4" modified="2018-10-10" version="1">MGQPVIPPNPPRTSLEGKTCLITGANTGIGFETARQMLTLKASRVIITARDKSKGQHAVAALCQDPEVVAANPSARIEMFHLDLDDYHSGLALCDQVKREVPDLDVLLCNGGMNIMSYQESKNGHEQVMQVNCYTHFLIVLELLPLLQATAVKRKSPSRVTFVGSGTQYHHTLTKAPLADNENVLSHYDDTKIYHGLQRYSDSKLVVNAFIRRLARIVSDSEVIVNNFCPGLVETTGFDRGIPRWLKIIMYVYRGTSSRPLKHAGWTAIYATAVSGRESHGKFMQSNKIDPGPPFLNQPAGNDFLERLWTDFVADVAPLDPKLKPFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X423</accession>
    <name>A0A317X423_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">FRE family ferric-chelate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_533161</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469426.1">
        <property type="nucleotide sequence ID" value="XM_025611274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X423"/>
    <dbReference type="STRING" id="1450535.A0A317X423"/>
    <dbReference type="GeneID" id="37113417"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016318428" evidence="11">
        <location>
            <begin position="19"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="434"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY91698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="763" mass="87064" checksum="BFD47D80367D4365" modified="2018-10-10" version="1">MLSLGWLFLLVYSGLALAGRPRTDEGCVTAVYTALGYLSFAGEPADGFWETRCQNPLKVISIYASSDVYCTPDEQAAGVGQLEGFCREFGNVDLIPRAQLAGNLTHDALSRMPVVDYLEISKSQRLPTPVLISPTYYRRTFQTIDTWQFEVWSHNAFGLVGYAFWGFILLVGITHRLVRHLLHSLDVRAGQWSRSQIRWLWVPLDGVYHWVQTHLVVSSPLSAPRRQLLWWTFPTRIEAVTILLFWVMSAVFCTLGYRVVEGNIYWPTISSQLLRYAADRTGVLCFANIPLIWLFAGRNNIFIWATGWSFATFNLFHRHIAWIATFQAVFHTLLYLVIMTQKGNVAKKLRKPYLIWGTAATVLMVLTLPFAVQWFRHRLYETFLLIHILFSLGLLVGCFYHTVIFEGHKYWNYLWPAVIIWIVDRFLRLVRLVYCNIHVRLNAGYQIQRTNSSATYDPAADVIRLELTPGSSMIRPTPGDFYYLYQPFRLTGWESHPFTLGYWSYETRYQTSSQPRSSKDHSVDVSQVPLLSDSSNTSDEMQLKQSDQQGLRFVFWIRPYDGWTRSLRQQCTQSPDLTINTTILLEGPYGNPFPLWSYESVLLIAGGTGIAAVVPYIQGHLLRSSTDSDQPTTTMQTREMHLIWTTRQSSFIHQVASRELAPALTRDDFRASFYTTGSKFSPAESTGNHSAGGIENKVETLEGRPDLESLILDHAEEAQLSESPAAVLVCGPAALADEARAAVHLAMRRGYRRIRYVEESFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4K2</accession>
    <name>A0A317X4K2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_511205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470315.1">
        <property type="nucleotide sequence ID" value="XM_025609753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4K2"/>
    <dbReference type="GeneID" id="37111896"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="287" mass="31595" checksum="DD4A8CEB3225E37E" modified="2018-10-10" version="1">MTTPERKYYLVTGASRGLGIGLVQQLLGRPETTVIAAVRDIESASPRLLALPNEKQNTLIIEKLDSANDDDALTVLESLKEIHQIPHLDVIIANAGMSQEKASAAVVRKQAMRDHFNVNAIAVLLLYQATKPLLRSGGKFVAISSTSGSILDVAARPSSNIAYGSSKAALNYIIRKIYFQDKDLITFPVHPGWVQTDMGNSSARKQGLEQAPVTVEESTRGILDLIDNATRENSNRFLDYNGDEVPWSTCISYLLDLAIEVVSRNVVVYNLHQLRTLTKSMIINHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X641</accession>
    <name>A0A317X641_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_487511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469788.1">
        <property type="nucleotide sequence ID" value="XM_025609040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X641"/>
    <dbReference type="STRING" id="1450535.A0A317X641"/>
    <dbReference type="GeneID" id="37111183"/>
    <dbReference type="OrthoDB" id="5100247at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="143" mass="16350" checksum="E9DD6C4809EDC79E" modified="2018-10-10" version="1">MAAPPSQIVEGIFLEFSIEEILTRNTQGFPVVEPWATDYVNAVRDKRYGDAIWARYHIAGDVHDGISEEENKPVLEVIEDEALNYKVSDPEAYAEALVFYADTSSADGHPEVMEIIRRIGNMDTTELRAKYEREQWEDHIADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X697</accession>
    <name>A0A317X697_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_544002</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470596.1">
        <property type="nucleotide sequence ID" value="XM_025613160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X697"/>
    <dbReference type="STRING" id="1450535.A0A317X697"/>
    <dbReference type="GeneID" id="37115303"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="33"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY93835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="454" mass="50933" checksum="C6BB242C1AA9C2C2" modified="2018-10-10" version="1">MGVTAEDMIPAPGEWPVDPQEDLPISENRIWVDGCFDFSHHANAYPKLSSLGHAGAMLQARRLGDELFVGVHSDEAILENKGPTVMTLDERVAAVEACRWMTRCVPFAPYVTFLPWVSHYGCKYVVHGDDITSDSNGEDCYRFVKAAGRFRVVKRTPGISTTDLVGRMLLCTKNHFVKSVKDTLIGVEGSGNLEERKQSADSLMQRIRDYATDETGLQPGPQVWIWSGSSSAKLEDTVEEPGEFETIVNGKLPRPGQRIVYVDGGFDLFSSGHIEFLRQVLAQEESEGHRRGWYNQAQKEKRFKDHGEDYGPAYVVAGIHDDDVINHWKGLNYPIMNIFERGLCVLQCRYIHAVIFSSPFSPSKPYLEAMPLGPPDAVYHGPTTFIPLTYDPYMAPKRMGIFKETSSHPYQNVNAGEIVDRILKSREAYEERQRAKLEKGAVEELVKSKELASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6Q9</accession>
    <name>A0A317X6Q9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_317014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470776.1">
        <property type="nucleotide sequence ID" value="XM_025606873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6Q9"/>
    <dbReference type="GeneID" id="37109016"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="88" mass="9665" checksum="B5826B1078E83EBE" modified="2018-10-10" version="1">MRRAQPCPAGMSSTLLYVSYDSACLFIGDVILFGLVRIMYAPDFPTLLLLPGHSIPTGYFPPHGDRSRFPTADSHFSDATATSARLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8W0</accession>
    <name>A0A317X8W0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_571671</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471804.1">
        <property type="nucleotide sequence ID" value="XM_025614882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8W0"/>
    <dbReference type="STRING" id="1450535.A0A317X8W0"/>
    <dbReference type="GeneID" id="37117025"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="10">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY95043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="238" mass="27390" checksum="621C2426D4CAF6B7" modified="2018-10-10" version="1">MDYQNRAGSKFGGGGVASQSATNADRRERLRKLALETIDLEKDPYFFKNHVGSFECRLCLTVHQNDGSYLAHTQGRKHQTNLARRAAREQREGKNQDPSSIAGAMGVQVKKQTIKIGRPGYKITKIRDPLTRQLGMLFQLQYQEITPGVTPKVRFMSAFEQKVEEPPDKNFQYLVVAAEPYQTCGFKLQAREIDRREGRYWTWFDEDSKEFWVQIMFKTEREERFSGVPGLAPMESKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X908</accession>
    <name>A0A317X908_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thymine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_456728</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471854.1">
        <property type="nucleotide sequence ID" value="XM_025607713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X908"/>
    <dbReference type="STRING" id="1450535.A0A317X908"/>
    <dbReference type="GeneID" id="37109856"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000030">
        <property type="entry name" value="Thymine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="180"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="335" mass="38891" checksum="713F3E5368FEAD48" modified="2018-10-10" version="1">MKIPVVDFSSWYNTQDESSRQRVAHELVEACQKVGFVYIVNHSLTETTLVATFDWMRRFFELSDEQKMQAPHPEGWAVHRGYSWPGLEKVTQVMSNGDYEESREKLREVPDVKEICDIGSENNTDQPNQWIPKETLPGFQAFMVRFYEECHKVGSEILRALATGLDLEDEYYLTKKHSGYNNQLRLLHYLPVPAEDLEKERTSRCPAHTDWSSITLLFQDDCGGLEVEDVSRPGTFAPANPLKNAIVMNVGDLLQRWSNNRLRSTNHRVRLPQLSDRFEGPNRMTRERYSIPYFMSPDPDMVIECIPSCMSEENPAKYKPITQAEYNQMRASMMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9A2</accession>
    <name>A0A317X9A2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_532886</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469901.1">
        <property type="nucleotide sequence ID" value="XM_025611214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9A2"/>
    <dbReference type="STRING" id="1450535.A0A317X9A2"/>
    <dbReference type="GeneID" id="37113357"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="497" mass="55862" checksum="2BDEEEA34D4A2DE3" modified="2018-10-10" version="1">MGGIPYTSSGCATCRKRKIKCDLGKPECAKCIKKGTPCPGYDDRNFLHHTVVSRRARNGETKRPVPQLVGQLKPLALPEQFDMSAEARTQLFATFMDTFFASACLKGKDDSWYLLMARFPTMAGQSELLDRSVIGLASVFLGKTMRDSQLAYHGLEIYNSALNAMARVLKFDDSPSLAVLYSAIVFQTYETMQNSDTVLRNCLTHIQGATAMLNHHGYNHHTDKALIKAIVSRQKWAASMFILNTPYSTEVNGECLILGREESPNDQLFGVIAECIFLRRDLGKIIKLQHRDREHACQALLQGCYKLKKRLHVDWILESTHKLGGKPSPCHREKLTPDPSLLPLDPDLAPYEFESLETAKTYILFCVASIVIHRMIYQTEKLLFRNPDPSYMLYYAREICRTVAYCMQPTTRMSAGQAVLMGLSQASKCYIDCGDKARFLWCQAIYPLIEASGFGIALRMSQVEWKYWNAAGSQSMGSTLLLPEVLQDGIEISTNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9Q8</accession>
    <name>A0A317X9Q8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_622010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470399.1">
        <property type="nucleotide sequence ID" value="XM_025617039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9Q8"/>
    <dbReference type="STRING" id="1450535.A0A317X9Q8"/>
    <dbReference type="GeneID" id="37119182"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="355" mass="40291" checksum="E8634460A2C80A1C" modified="2018-10-10" version="1">MFCTLRRSKNTMESYASELTTPPFAKPKSKFNAACANCRKSKLKCSGEPQGCQRCLTKNLQCNYLSFREGVSHNKSHTGPSETFPTEGNAVVETESEVQTHDSEVVSLSFDTLGCVDGFPIFGLSAAMPSRGDLDADLSSGISPCFDFEQQPALEPRTQTTDLDLNHLVNYHTQTPMEVSTIAEHVCLCFTRAVRIHEALEVDLLWINKKRCRDALDMLQHQKRNLVNSKILFECQHCEIQSPYVMLLLSILSKTSSALEFVFRDSRLGHTDCMFEVQQGENDHHTSCHHKSTFAMRQLDEEDERLVLKSLFKSRVAMLKALMTRLESMVRDQDWPAHKIKVGDLKDKVKDMEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9S3</accession>
    <name>A0A317X9S3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_609554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471138.1">
        <property type="nucleotide sequence ID" value="XM_025616583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9S3"/>
    <dbReference type="GeneID" id="37118726"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="193" mass="20394" checksum="C1F7449736BE68B6" modified="2018-10-10" version="1">MDLINGSAPGSDTLEVGLMPLPVPLFRTGEAGGHSVITAIVNIINQILPTFLPPSSPRLRLSGPPSVQGNHSALLSTAERNLSHTEDLPDRAWLVRPALTSSGRAGLVGVAVVIFDWLIVQIAWPGTDRWANQATLSGNNNNNNPYSNTSSAGTIVLHGFDGVPPFPFPPADGNPSPITHHPSPFRVQTHASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9S7</accession>
    <name>A0A317X9S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO94DRAFT_620721</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472010.1">
        <property type="nucleotide sequence ID" value="XM_025616952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9S7"/>
    <dbReference type="STRING" id="1450535.A0A317X9S7"/>
    <dbReference type="GeneID" id="37119095"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PWY95249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="243" mass="26682" checksum="164FB32F9D8811BA" modified="2018-10-10" version="1">MSRRTSAMPSNTSTTSGVPPAGDGGQEKQKMLLSSETGHFSMIRALHLADLVTELNGFCGVMSVFSSMRYCLGDPHDYGAVWAALIFMPFGLFFDFMDGRIARWRKKSSLMGQELDSLADLISFGMAPAAAAFALGMRTSLDHLFLSFFVLCGLTRLARFNVTVAVLPKDKSGKSKYFEGTPIPTTLSITFFMTYCVSQDWVQENLPLGLIAEGTAFEFHPLVLLFVLHGCLMVSKTLHIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA34</accession>
    <name>A0A317XA34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF974 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_459896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470539.1">
        <property type="nucleotide sequence ID" value="XM_025607861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA34"/>
    <dbReference type="STRING" id="1450535.A0A317XA34"/>
    <dbReference type="GeneID" id="37110004"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055429">
        <property type="entry name" value="TRAPPC13_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23647">
        <property type="entry name" value="TRAPPC13_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 N-terminal" evidence="1">
        <location>
            <begin position="17"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Trafficking protein particle complex subunit 13 middle" evidence="2">
        <location>
            <begin position="223"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="36685" checksum="A64364CCAE77882E" modified="2018-10-10" version="1">MARPRALSGADAPKEPHAVSLKVLRLSRPSLSYQYPLPAAETKISGKASLSYPADNVDDQFILTPNLTLPPAFGSAYVGETFACTLSANNELPDEETSRVVTSVRIVAEMQTPSQVASLDLEPAEDTASKDGIQKGHSLQKIVRFDLKEEGNHILAVSVSYTETLIGSDAQAASGRVRTFRKLYQFVAQPCLSVRTKSSELAPLEVENKTLGPYGKTRLLRFALEAQLENVGDGPVVVKQTRLNPKPPFKAVSLNWDLEGPDQTDPQPPALHPRDVLQVAFLVEQKEGQQDGLDTLQKDMKRDGRAVLGQLSIEWRGAMGDKGFLTTGNLLTRRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA60</accession>
    <name>A0A317XA60_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">JmjC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470569.1">
        <property type="nucleotide sequence ID" value="XM_025611189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA60"/>
    <dbReference type="STRING" id="1450535.A0A317XA60"/>
    <dbReference type="GeneID" id="37113332"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="159"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="381" mass="42596" checksum="820BA6DC55C097F2" modified="2018-10-10" version="1">MKLQKCMRYNNPRVWHRLPSVALRFLSPNQPRQQRCFTSQSQSSPTASRQYRPLETLDNVDISHFRANYFAPERPIILPRRSFREFPAFERWFQPDPTDSNVSQLNTTYLGQHGADAFVPLELTQSSSDGTVNTGVDGLTFRQFHAPLSLFLDWISTAETLETQSTRLYLAQCQLLDLPQVLRDDFPTPELVAQAGKGDVYDTNVWIGYPPTYTPLHRDPNPNLFVQLAGQKVVRLLSPEDGQKVFGAVRRQMGMSGGREAAAIRGEEMMQGQERTLLEQAVWDDATVVSGLNGYEARLEAGDGMFIPRGWWHSIKGVGTGVTASVSSLISSVHAHAYLITGQLVVPLIKSTITEPGDKYVGDMVASLGSNLHLYRTEPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAH0</accession>
    <name>A0A317XAH0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FRG1-like family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_455327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472344.1">
        <property type="nucleotide sequence ID" value="XM_025607649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAH0"/>
    <dbReference type="STRING" id="1450535.A0A317XAH0"/>
    <dbReference type="GeneID" id="37109792"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30105" checksum="1D926F4A03189755" modified="2018-10-10" version="1">MVKPLTFKGDKPKKRKHTSDSSAPKKKPTLTSSESQPQSAPAIEEEDTSTLSDQSWVSADTPSDISGPILIVLRTNPPTCLATDAHGTVFVSEIENLIEGDPATAEPHDVRQVWVATKVAGIEGWSLRGGSGKYLTSDKHGILSAAASAVSRHEIFSIMESESGGDGFFNVGTASSDTASSDTSGVKIEVRGDETRLDSNEGTNIRVRMQARFKPRIQASKEIKAREKIGRKELEGIVGRRLDEDEVRRLRKARKEGDFHEAILDVRVRGKHDKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAK5</accession>
    <name>A0A317XAK5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Ferrooxidoreductase Fet3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO94DRAFT_531125</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
            <orientation evidence="16">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471972.1">
        <property type="nucleotide sequence ID" value="XM_025610832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAK5"/>
    <dbReference type="STRING" id="1450535.A0A317XAK5"/>
    <dbReference type="GeneID" id="37112975"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000025">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 18" id="KW-0732">Signal</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016367730" description="Ferrooxidoreductase Fet3" evidence="18">
        <location>
            <begin position="23"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="568"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="21">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="19">
        <location>
            <begin position="156"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="20">
        <location>
            <begin position="367"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PWY95211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="68404" checksum="09EEEC6798221B3B" modified="2018-10-10" version="1">MAFPRHLLSWLAAVVFLAQCQAKTVTYDFNVTWVTANPDGLAEREVVGINGQWPLPVIEVDKGDQLVVNMYNGLGDKSTSIHFHGMYQTNTTDMDGPALVTQCPVPPGSSMTYNFTVNQNGTYWYHCHTDYCYPDGYRQALIVHDNSSWFADEYDEDLTITMTDWYHELTQEIAPTFITVDNPTGAEPIPDSFLFNDTLNTKIPVEPGKTYLLRLINIGAFVAQYFYIEDHTMRIVEIDGIYTDAAEADILYISAAQRYSVLVTMKNSTDKNYPIVTVADSVLLDTIPSDLKLNQTNWLEYNSSASFPQAVMTVSDCSDLDPYDDMGLVPYDRMPLLEDPDVSLELTVTMQVLDNGADYAFLNDISYTKPKVPTLYTVMSAGSLATDATVYGDYTHSVVLDEDQVVEIILNNGDTGSHPFHLHGHAFQMVDRFPSYGEHFYDYADGDPVTYNASNHSTFPAYPPRRDTFVLPPQGYFVIRFKADNPGVWFFHCHIDWHLAQGLAMVFIEAPLAIQERVTIPQQHYDVCEAAGIAYEGNAAGNTEDYTDLSGQNKQVAWLPGGFTARGIVALVFSCVSAFLGMGMIAFYGLSDIKKGAQAPTARREEVREHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAT7</accession>
    <name>A0A317XAT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_531688</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471513.1">
        <property type="nucleotide sequence ID" value="XM_025610953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAT7"/>
    <dbReference type="STRING" id="1450535.A0A317XAT7"/>
    <dbReference type="GeneID" id="37113096"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="12"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="682"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY94752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1068" mass="123607" checksum="89460D792EE197E5" modified="2018-10-10" version="1">MSIDFPHEEEVILQRWREIDAFRRQVELSEGRKPYTFYDGPRSRLVFLTMDIIPRYWSMKGHYVERRFGWDTHGVPIEYEIDKKLGMSGLEAVQKIGIEKYNEECRAIVMRFASEWRQTIERLGRWIDFDNDYKTMNVSFMESVWWVFKQLFDKDLVYRGYRVMPYSTALNTPLSNFEAQQNYKDVQDPAVVVTFPLVEDPETSLLAWTTTPWTLPSNIALAVNPTFEYIKILDEASGKHYILLESLLRTLYKDPKKAKFKIVDRFKGATMKDWKYKPLFDYFYEEFKDYGFRVLNAEYVTAEDGTGIVHQAPAFGEDDYRVGMEGGVISESRLPPNPVDEKGCYTAEVKDFEGQHVKAADRGIIKHLKAAGRLVVDSQITHSYPFCWRSDTPLIYRAVPAWFVKIGPIIPQMLQGIDDSHWVPSFVKERRFSSWIQNARDWNISRNRFWGTPLPLWVSDDFKEVVAVGSAEELKQLSGYEGELTDLHRDKVDNITIPSKQGKGVLRRVSEVFDCWFESGSMPYASQHYPFENKEQFEQSFPGDFIAEGLDQTRGWFYTLTVLGTHLFGKLPFKNCVVNGIVLAEDGKKMSKRLKNYPDPSLVMDRYGSDALRLYLINSPVVRAEPLRFKESGVKEIVAKVLLPLWNSYKFFEGQAALFKKTQGFDYTWDPKAEATNTNVMDRWILASCQSLLKFVNEEMAGYRLYTVVPRLLELIDNTTNWYIRFNRRRLKGENGVDDTLHALNTLFEVIYTLVRGLAPFTPFLTDTIYLKLLPHIPEALRSEDSRSVHFLPFPEVREELFDEVVERRVSRMQKVIELARISRERRNIGLKTPLKTLVVIHQDQQYLDDVKSLQSYILEELNILDLVLTSDEAKYNVQYSVSADWPTLGKKLKKEVQKVKKALPSLTSEDVKKFVAEKKMLVDGIELVEGDLVVKRGLKEDSSSANMEPNTDNDALTILDANLYPELAEQGLGREIINRLQRLRKKAGLVPTDDVKMEYAVLSDPEDVGIDKAFETQAQAIEKVVRRPLDRYELVHGKLPSGDEPEMIIQEEQEVQKATFLLRLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB56</accession>
    <name>A0A317XB56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flavo protein WrbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_530481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472500.1">
        <property type="nucleotide sequence ID" value="XM_025610681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB56"/>
    <dbReference type="STRING" id="1450535.A0A317XB56"/>
    <dbReference type="GeneID" id="37112824"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="203" mass="21558" checksum="C0455DF29BB31EA9" modified="2018-10-10" version="1">MAPKVAIVFYSMYGHILKLAEAEKKGIEAAGGTADIYQVAETLPEEVLAKMHAPAKSSYPVVTPETLLEYDAVLFGIPTRYGNFPAQWKAFWDSTGKIWASGGYWGKYAGLFVSTGTQGGGQESTCLAAMSTLAHHGLIYVPLGYKTVFGQLANLDEVHGGSAWGAGTFAGGDGSRQPSALELTVAEAQGKAFYEHLAKVNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBC9</accession>
    <name>A0A317XBC9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BO94DRAFT_507177</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17 18">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472604.1">
        <property type="nucleotide sequence ID" value="XM_025609604.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XBC9"/>
    <dbReference type="GeneID" id="37111747"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18802">
        <property type="entry name" value="SF2_C_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000015">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000026">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.380:FF:000004">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001669">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001988">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 18" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="123"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="438"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="24">
        <location>
            <begin position="641"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="21">
        <location>
            <begin position="881"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="20">
        <location>
            <begin position="1048"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="20">
        <location>
            <begin position="1243"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PWY95843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1525" mass="172432" checksum="065FE7A8C29A8BBD" modified="2018-10-10" version="1">MASTDTIRRVNIQRPVQAPAAKSFIEHAGASTQDTPDKDDSSSDESNDDEQESSNQTGVTQQRRIQNAKFEALLAQRADTAPANVTRAVPCDLPDAQLSTAHLVAKQDLGSGTLDPREYQVELFERAKLQNTIAVLDTGSGKTLIAVLLLKHTIQKELNDRAEEKPHRISFFLVDSVTLAYQQAAVLRNNLDQNVAHFFGAMGTDLWNKQVWDEHFQKNMVIVCTAEILNQCLLNSYIKMSQINLMIFDEAHHTKKDHPYARIIRDSYLEVTPSNRPRIFGMTASPIDTKGDIIEAATRLETLLDSTIATTSNLTLLRQVVRRPVEKIWPFNKLDQPRATKLYKILEDRFGDMACLEAIFRFAWQASAELGPWCSDRAWARALADDVLPKLEGNVNKAMNSEAVTKVPEGAYKEVLRIKEASEIVKNHTFNSPDAPGQLSSKVQLLREELGRYFGRQTETKCIVFTQKRYTALILSELFETLNIPFLRPGVLIGVRSGDLSGMNITFRQQFLALVKFRNGEINCLFATSVAEEGLDIPDCNLVIRFDLYNTLIQYVQSRGRARHFNSTYASMVEKNNPEHDERLLEVRDAERMMQNFCRTLPEDRLLHGNDHDLEVVLQREEGNRSLTVKTTGAKLTYHSATAILARYASSLQYEKESSAQVIYVVLPSNSAYVCEVILPEKSPIRGVTGGPAMRKSIAKRSAAFDTCLLLRKNKLLDDHFNSVYHRRLPAMRNAKLAITSKRTSQYDMISKPSIWSQNRGLPPKELYATVIKFLPSKPLLHDPRSLLLLTRERLPEFPKFPIFLDEDIETTVHTIPLTEKLILSAEEVDWLTTFTLRVFRDVFHKTYDKEPEKMAYWLAPAKAQSSYNPTRDPRQTMEWKSLLFVSANDGIAFSKDAAPESMVDRFVFDAWDGRCRYFTVAVEETLRPSSPPPPFVPRRRHMSDIMNYCLSLSKNSRAKFLAGCSWDQPVLRAELVRLRRNLLDKMTDTERDVETKCFICVEPLKVSAIPASTAFSCLAFPAIISRLDAYLICLQGCEALDLVVYPELALEAFTKDSDNTEDHRAQQIHIQRGMGKNYERLEFLGDCFLKMATSISLFTQNPDDDEFDYHVNRMCLICNKNLFNTAVKKELYRYIRSRGFSRHTWYPDGLSLLQGKDHSKKVSTEAKHALAEKTIADVCEALIGASLLSGGPDHRFDMAVKAVTALVGSSNHNASCWRDYISLYSIPKYQSQAPDGSELDLCKKVEEKLSYHFNYPRLLGSAFTHPSYPSAWAQVPCYQRLEFLGDSLLDMVCVEDLFYRFPDRDPQWLTEHKMAMVSNKFLGALSVKLGLHTHLKYFSGPLQSQITHYAEEIQTAEGESEGAVDYWTVTKDPPKCLPDMVEAYLGAIFVDSNFNFEVVEKFFKGHIRPFFKDMAIYDTFANKHPTTFLHNRLTNDYGCMNYCLKAGEMPAIDGAPAGVLAAVIVHDAVIAEGTASSGRYAKVKASENALAVLEDITPAEFRKQYHCDCRESDGSASLDMGTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC67</accession>
    <name>A0A317XC67_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_529545</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472894.1">
        <property type="nucleotide sequence ID" value="XM_025610468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC67"/>
    <dbReference type="STRING" id="1450535.A0A317XC67"/>
    <dbReference type="GeneID" id="37112611"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="251" mass="27393" checksum="FCF161787586D0A6" modified="2018-10-10" version="1">MEKQQPTVAFFGATGGCLNACLALALQAGYHCTALARTPSKLHDLLHQHNVSDSAIEDYLTITQGNVTDIQAVQQTLHHNGRPVDLIISGIGGKPRFDCVFKPTLDNPTVCQDATRTILAAAQSSSRKPRLVAISTTGLSNKRDIPVMMMPLYHWLLKVPHEDKKVMEGQIVAEMEKPVAERAIDNYLLVRPSLLVDGNGDGLAKIKTGTDTNPAIGYVICRRDVGLWIFENAIRRASDSPSWGQIVTLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC73</accession>
    <name>A0A317XC73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translationally-controlled tumor protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_531213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472053.1">
        <property type="nucleotide sequence ID" value="XM_025610851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC73"/>
    <dbReference type="STRING" id="1450535.A0A317XC73"/>
    <dbReference type="GeneID" id="37112994"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018103">
        <property type="entry name" value="Translation_control_tumour_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01002">
        <property type="entry name" value="TCTP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="179" mass="20150" checksum="D1236A0200604447" modified="2018-10-10" version="1">MIIYKDIISDDEVLADTYNIKTVDGVLYECDCRKYLKKANEDFELEGANPSAEGGDDDAGGEGESVMVHDIEDQFRMNWLKVEEGLKPSKDAFKAHLKTYMKKVLTKLTEKGAPQETIDEFKKGAPGAVKKILANYDNYDVLMGQSMDGDAMHILIDFREDGVTPYATLWKHGLEEMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC82</accession>
    <name>A0A317XC82_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_507390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472706.1">
        <property type="nucleotide sequence ID" value="XM_025609608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC82"/>
    <dbReference type="STRING" id="1450535.A0A317XC82"/>
    <dbReference type="GeneID" id="37111751"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="71979" checksum="8F392F478F290780" modified="2018-10-10" version="1">MRQAAERMKQAEERMRQEWKRGQRSTFTELLCFCHNLLSRPLRIESPSHSTTEPIPLSIGKYCPVRLEPWTDCAAQLQEIYNSVCSYLEPTDGDGARLFVPRVVLEEDARRVHLYPMDGERALRYYERFAVEGHVSDIVAELCKIKAAQDQFGLGNGIRFENHTNTLDDTNRIEEANRRQPSTIEHPTPDQFCIYRNDEGTDTLLTSVEYIPGHKLPDETIRLGLRPMYVWRDMVYSNKIPREGEEKLKYDAERLVCSALVQEYHVMIQEGLEYSYVANGTARVLLRVPSDDPSTLYYFFCDPNRELEGDIAQSLQEPKTSIARVLCMCLMAFGSTVRGQEWRQAAQSGLPLWTSNFDTGSEIPQDVLQQSGSQSDSSSKQRVAHERKTKDNRGSQPGGHDALFCTQRCLLGLQTGGNLDDSCPNVKLHRQNQTEVKHPLTSENLVRFLKAQLDENIDRCIPLGGCGAYGAPFKLTCVTYGYTVVGKGTTSGLWKQVSREAKIYQILQKAQGSAVPVFLGSIDLLKTYFLHGAGAIRHMLVMGWGGETTAKMEPTSSLDQEIRRSSAEIEALGIRHEDLRRDNILWNEELGRALIIDFHRSTFINQQLTSHRPQKAKRRLSSEETRDGKRLHMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCB8</accession>
    <name>A0A317XCB8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_621615</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470941.1">
        <property type="nucleotide sequence ID" value="XM_025617010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCB8"/>
    <dbReference type="STRING" id="1450535.A0A317XCB8"/>
    <dbReference type="GeneID" id="37119153"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="277" mass="30744" checksum="F272F51E040331A2" modified="2018-10-10" version="1">MLSAEKTGQLIYEKRRRQGIPRLRQQAAAAIAIEDNGTLLFISLHPIYYSLPPLPSPPPLTSSSGLRLDSTQLTKNTHLKHHAPQKAHRNNNPHHLHPTPKRPRARQSKLAKENDISAEEETEIKEVFHLFTEPNNEFPDEKEGVIPREDVRKALVAMGLEPSSSEELHSILEAVDPTDTGYVPYGPFLTVAAAKLRSRSEEAMSAEVDAAYRLFTKGSGGLITFNHLRRIARELKEDGLGDELLKDMILEANGGAGVNAGVTLEQFHEVMQRAGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCM7</accession>
    <name>A0A317XCM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_509316</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471449.1">
        <property type="nucleotide sequence ID" value="XM_025609697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCM7"/>
    <dbReference type="STRING" id="1450535.A0A317XCM7"/>
    <dbReference type="GeneID" id="37111840"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="575"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="620" mass="68047" checksum="0DE0797C2A1E20FE" modified="2018-10-10" version="1">MARRDSIRGIADEHRYRSSSPRARRAIARDIEDYADDEGSMLTTDDEASETSTIRAINSQPGTRPHSLAGSYQRPSFFTTVSHATVVPHRPDHDGLTRRERERAIEDERNLLTDNNFIESSPHKGRRMRLGSATGPETASLLGGEQRGSQYDGVDSEEIDRKWEEAVTAGLIQTTWKREAQVIGKNAAPLVVTFLLQYSLTVASIFTLGHLGKKELGAVSLASMSASITGYAVYQGLATSLDTLCAQAYGSGRKKLVGLQMQKMVFFLWVISIPIILLWFFADRILIRIVPEEEVAILAGLYLKVVALGAPGYACFESGKRFVQAQGLFSASLYVLLICAPLNAFMNYMFVWQFGWGFIGAPIAVAITDNLMPLFLFLYVYFVDGSECWNGVTTRALRNWGPMIKLALPGLLMVEAECLAFEVLTLASSYLGTTPLAAQSILSTISSITFQIPFPVSISGSTRVANLIGATLVDAAKTSAKVSMVGAVIVGLLNMLFLSSLRYYIPYLFTSDEEVIELVAQVLPLCAAFQLFDALAANCNGILRGIGRQEIGGYVQLFCYYAIAMPISFGTTFGLHWGLFGLWSGVALALLLVSIIEAFFLTRTNWNRSVEEALRRNALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317URM8</accession>
    <name>A0A317URM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_387109</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000081">
        <property type="protein sequence ID" value="PWY64285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461273.1">
        <property type="nucleotide sequence ID" value="XM_025607297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317URM8"/>
    <dbReference type="STRING" id="1450535.A0A317URM8"/>
    <dbReference type="GeneID" id="37109440"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000021">
        <property type="entry name" value="MUTL protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="252"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="425"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY64285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="612" mass="65543" checksum="53487CAB39CA2E94" modified="2018-10-10" version="1">MAVSAPTPKLDRYIVIHVATTCDEHGVYVTKDSAEVIELGWILLDTKTCEELHHESVLVKPVNTPITPLCTSLTTLTWEHVRSAGTFRDAINRFDAFAQEHLISKNLEFAFVTLDSWDLRVQLPREARDKAVVLPAYLQHSRTFDLRTEYQRWQTHHPESLPFGPSSLSNICAALEVEPVQSSAPIKHNLPFHLQALAPASPRRAMEEAITLARVLRGLIRKSQPPHEHPEILTRPMDARADVRAFLTERSKVLHLSGLPHDTTQSELESWFTQFGGRPIAFWTLRTPDQHKPTGTGFAVFSSHEEAAESLCMNGRALNEKAIEVSPSSSRVLDRAAEILTPFPPSKNRPRPGDWTCPSCGFSNFQRRTACFRCSFPAMAAAPDPMGYGAYGYGPPSMMPPHMGHGHGMGHSRGMGGNGGVVPFRAGDWKCGSEGCGYHNFAKNINCLRCGAPRSGAAVVADSAFPSPMDPPSSFGMGPNSMSSTPAPGPFTASTGSFGGFSQQFAAPPNNYALPSGLGSAPAAYPPMGQMNAGYGSANASHSAASFANPAAQAAFTGADHTSSTSASNGAFYGNDGSSDPFAFLSTGLGGLTVGEDAHSRRNGAGANKSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVF2</accession>
    <name>A0A317UVF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_480323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000064">
        <property type="protein sequence ID" value="PWY65018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461369.1">
        <property type="nucleotide sequence ID" value="XM_025608790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVF2"/>
    <dbReference type="STRING" id="1450535.A0A317UVF2"/>
    <dbReference type="GeneID" id="37110933"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY65018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="544" mass="60703" checksum="2747CD9430473218" modified="2018-10-10" version="1">MTAILPASNEGRSRFSSDPLRCPITQTYFLDEPNIATAKFNVPEFHRRDCPDDAAPPSPRSDSSSPDFTITAVDHFPPTPTTLSSLSLMSEGQEDGDLVLPSYDSSQFDQKEPKALSDVSVDSSADLQRLTQAPAADDSTIEDEPSRHVDYLSHEWRQEDIWASWRYVVARRNVYDNGVRLENASWRTWAKLKLNLGTVSPEALNWLKDCDVTWLYGPLKTCTRREKPSNGSPPPSCLETPTMYPDRKPILKKRTASETILQRSLSQHTLLQHAGAILKAQEAETNRNRPPFQRCPSEFGQILNKSSTTLVGDSANGTVTNTSSSGIGSPSERRHIHFNNEVVQCIAVEAKEEDDGWPIPFDEESSEDGIVMMKQIHSDTSISDKSTPRGSSIGENKTIAPLPSTTLKYRWDNRRDTPQPPASSIMNRWSSYFSKSTPSSSGSVKPSRASAPSANFLLDEEDNDLAFDWEPSRNSYSFGSLSRSWFVNPEDDEELDYYFHSMSPGGSTPNEDEPLSASIFDRVADTVNTAKDIAHVIWNVGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWY7</accession>
    <name>A0A317UWY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_334739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461546.1">
        <property type="nucleotide sequence ID" value="XM_025607004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UWY7"/>
    <dbReference type="GeneID" id="37109147"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY66036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="141" mass="15602" checksum="4ECA0883D653A0E6" modified="2018-10-10" version="1">MCWEDGEIKRRVDRWRQRASIQQMSVACWPLLSEPWIFPSSPSLIFGFLSQNSSRLGRGGYDRNDLAGAGAGLNPVTTVMVPCLIISPLLLINGCQSAGNFAMFQRNYFLGSPSGFPTRPTELRALTHALVYHSLINASLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V000</accession>
    <name>A0A317V000_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461983.1">
        <property type="nucleotide sequence ID" value="XM_025612912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V000"/>
    <dbReference type="GeneID" id="37115055"/>
    <dbReference type="OrthoDB" id="4399101at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="59" mass="6763" checksum="4820B86DD049B861" modified="2018-10-10" version="1">MPITSLPPELVSAIRGYLEVSDWCALRLTCRFLFVHLLDDFANRHFDRISVLITSDGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0N7</accession>
    <name>A0A317V0N7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_479537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461651.1">
        <property type="nucleotide sequence ID" value="XM_025608749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0N7"/>
    <dbReference type="STRING" id="1450535.A0A317V0N7"/>
    <dbReference type="GeneID" id="37110892"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY66387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36328" checksum="8B9210D6B9CAAB80" modified="2018-10-10" version="1" fragment="single">MVNSNDEDLEVCDYTIGWISTTDDEYIAATWVVDELHEPNTSLRRLNDQRKFDYQLGRMGNHNVVICIPATGPEFTVAAVIDDMLLTFTSLRFVLLVGTASGVPPVKNNHEGIDEHAADVRLGDVVIGTSIVVPYSRGAVQTPGTELKHQPSRTISTGITEFKRRLAGGLGIGLSLSSLVEQICMTDDHFKCPHPQSDCLYQTEYAHIPRCCECLVPSPKQVLVTISRPQRTQDREFQVHYGAVGFVDQRIMDAGIRNELSLENNVLCFQTGTTDVTTKIDCLPIRGLCDYADSHQYRGWSGYAALTAAVYAKEFLGSVTEYMVSGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V163</accession>
    <name>A0A317V163_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_479100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461853.1">
        <property type="nucleotide sequence ID" value="XM_025608733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V163"/>
    <dbReference type="STRING" id="1450535.A0A317V163"/>
    <dbReference type="GeneID" id="37110876"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY67131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="200" mass="23041" checksum="1EB0D5CF17E078E2" modified="2018-10-10" version="1">MQQLEAMIHLEFATGSPRADLLLPVTRLNILRALDTNLDVLGYRAIDMRDDDVLSMFSTNGPRCAATQNREDFLPPALQPTLIQRTIPHHPWLDLIPIPKMRDNLILVESVMDDTQLCYDMCGHRRSQAGNGRNSGIGETGVIVWKDPWDPEGWEVTETFVQLWGWAMQDCWELFQSTNAWRKQRGERPLFRCSEPKDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3A7</accession>
    <name>A0A317V3A7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_540322</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462151.1">
        <property type="nucleotide sequence ID" value="XM_025612895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3A7"/>
    <dbReference type="STRING" id="1450535.A0A317V3A7"/>
    <dbReference type="GeneID" id="37115038"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000070">
        <property type="entry name" value="Translation elongation factor EF-1 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015033">
        <property type="entry name" value="HBS1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08938">
        <property type="entry name" value="HBS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="166"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="83"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY68129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="576" mass="62594" checksum="1804F717AAD841C3" modified="2018-10-10" version="1">MSRHRVKAVSYDEDDFDDGYDSPDPEEQEFLQQCTTEVLNQLRAGDPSVTATRDEVQEALWHYYNDVEKSVNYLRNKKAKEIKKKAPAPAAVPATKAKGPSPDDVILNAQSSAKGFKSKQPAAKAGDKKSQAGLSEGMNNLSVEEKVNVKSKNLDVLSEYQKSQRKKAMNFAVIGHVDAGKSTLMGRLLADLKAIDQRTLDKYRKEAEKIGKGSFALAWVLDQGSEERARGVTIDIATNKFETEKTVFTIVDAPGHRDFVPNMIAGASQADFAVLVIDSGTGNFESGLKGQTKEHALLVRSMGVQRIIVAVNKMDSVQWDQERFDEIEQQVSSFLTTAGFQAKNIAFVPCSGISGDNVTRRSDDPNVSWYKGPTLIEELEATEAYSHAVDKPLRMTIGDVFRGSVQNPLSISGRMDAGSLQVGDQILTMPSGEKATIRSLEVDGEPSDWAVAGQNVTLNLVNIDPIHLRSGDVICRASAPIANVTSFTCKVLAFDHLLPSMVDIHRGRLHVPGRISQLVATLDKVSGASIKKKPKIVAPGTVARIVVEMDQAVPLEAPTRIVLRAGGETVAAGLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5I2</accession>
    <name>A0A317V5I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_540316</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462144.1">
        <property type="nucleotide sequence ID" value="XM_025612892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5I2"/>
    <dbReference type="STRING" id="1450535.A0A317V5I2"/>
    <dbReference type="GeneID" id="37115035"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01887">
        <property type="entry name" value="SPECTRNALPHA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="214"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="371"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="475"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY68122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="607" mass="67282" checksum="F2728EF5C4AB1DA5" modified="2018-10-10" version="1">MFRAQQNAFDDAVAKATDENLTSENWEYILDVCDKVGSEESGAKDAVAAMIKRLAHRNANVQLYTLELANALAQNCGPKIHRELASRSFTDALLRLANDRNTHQQVKSKILERMQEWTEMFASNPDFGIMEQAYMKLKTQNPNLQPPSKPGKREITDTDRQKEEEELQMALALSIREKPTVAAAPQPEASSSAAPVNQAPAAASQPVPSGTSAATVSRVRALFDFQPSEPGELQFRKGDVIAVLESVYKDWWKGSLRGQTGIFPLNYVEKLPDPTVEELQREAQMEADVFGQIKNVEKLLTLLSTRSSELNVQDNEEITALYHSTLAIRPKLIELIGKYSQKKDEFTQLNEKFIKARRDYESLLEASMSHPAQPQYGRPAQPPYGYPGAAAPVGYPQGPPPADPQRYFSPRPQETQPPQPNPSAYYGADQAQVYPPSSQSPDPRRTPPTGAPYQQQQRQSSTESYQPVYHRPESTYENPQELGTSVYDSPIEHPSSGQRPQYSGHVQVPAAVQQHFQQQQQQQQPQPEYPASAYAPEDASRPPAGASSAHQPQPPYPSHQAPPMHQPPPIPGTSTTPTPYPALNAGGSYQAYNPSQTDVSNPASFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6W1</accession>
    <name>A0A317V6W1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_590693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462235.1">
        <property type="nucleotide sequence ID" value="XM_025616050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6W1"/>
    <dbReference type="STRING" id="1450535.A0A317V6W1"/>
    <dbReference type="GeneID" id="37118193"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY68572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="680" mass="76424" checksum="4815FA3C1BAE3C98" modified="2018-10-10" version="1">MSSSMPEESRRKRVRKGTKSCWECKRRKIKCVPSQDNAICASCLDRSTPCLSQEYVNDPAPHHADYSALAERMARVESLLEALMDRMTPSSITARTDSQPLVASPSNASGLQAEVAPLSSKLEILRLQLAAMLPCQADVDCLFASSHGCWLIQQHMMPDSPDSVDHQLFNVSEVSKQHPITITRLLLCIAICIQQLPFDMNLPTLQTTAPLRDVMSDIIDFIVQNVTSIDELTGSTESVECLALQGMYEVNAGNLRRSWRTFRRAITIAQLLGLHRVAVTPSQERQNSIKTKQHHLWYQIARGERYLSTLLGLPSSTGSAVFPCDDDASWLSLEDRYHKHLYHISGLILARNQGDGTHSFSTTQQISEKLDALAEQMPPSWWEIPTKIPTNRTKEASAQFERIMCQIWHFELATLVHLPFMFRAATDRRYEYSHISCLDASRNLIQRWIFIRESHNMLLFSNLLEFQAFTAATTLLLGLLAAPKSTNQGILQERCEDSQLIETVVANFERRKQHGIGMSVGTQSISVIRTLQQFLHGRNSSDRLCVEIPFFGVIKIVRGAVQPLEGERLLGANVCQSASFLGPAQSTAFSSMRTERISTSMTYPRNQTPRKTDENEDNAFNNSMGIENTIFHFSGGHFQLPGALSPIPEGLDPSEWTFNESDMIFFDSLINTDLIGNWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7W1</accession>
    <name>A0A317V7W1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/FMN-containing dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_540117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462257.1">
        <property type="nucleotide sequence ID" value="XM_025612841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7W1"/>
    <dbReference type="STRING" id="1450535.A0A317V7W1"/>
    <dbReference type="GeneID" id="37114984"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016336666" evidence="6">
        <location>
            <begin position="20"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="111"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY68942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="568" mass="60967" checksum="21CC44CC45B24CF2" modified="2018-10-10" version="1">MKASWTLAAIAALTSQAVASSDCHCLPGDSCWPSTSTWESLNSTVGGRLVATVPIGTPCHDPTYNGTACTDLQDNWYYPQTHFVSSSSVMQPYFANQSCDPFTAESKPCVLGNYVSYAVNVSSTADVVAAVQFAQSNNIRLVIRNTGHDYLGRSTGAGALSVWTHYLNDVEVQEWSDSTYEGKAVKLGSGVMGYQVLDALYGTGIVVVGGECPTVGLAGGFTMGGGHSALSTSFGLGADQTLSFEVVTASGEVVTASRTNNTDLYWALSGGGAGNFGVVTSLTVKGHEDATVSGAEVEFTVANITSDLFFEAVARFHTLLPAMVDAGTTVIYEMTNQVFLINPLTAYNKTSAEVKTILSPFLSALTELGIEYTVAYTEFSSYFEHYEKYMGPLPYGNLEVGSYNYGGRLLPRETLETNTTNLVAALRSITSEGVIAVGVGLNVTHSNDVSNAVFAPWRSAAVTMQIGSPWNETAPWSEMVANQEHIADSYVPQLEAVTPNSGAYENEASFRQHNWQEAFFGDNYAKLCEIKEKYDPNHVFYVLKGAGSEYWSVDESGRMCKTEQSCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9W1</accession>
    <name>A0A317V9W1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_438154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462749.1">
        <property type="nucleotide sequence ID" value="XM_025607496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9W1"/>
    <dbReference type="GeneID" id="37109639"/>
    <dbReference type="OrthoDB" id="4267316at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17615" checksum="8063798CEDEF92B4" modified="2018-10-10" version="1" fragment="single">TGIPNFYGSYSMDFTHPDGRHCTVRLILIELVDGCTMNTLDPKSLSQLVRKAIMEQIITVESRVYEIGVDHFNTYPRNVLIEGLEMGPSRVHIKLVDFGHAKIGRSPHPEQIPESHYLGGTSISPILRWTTDGEREPMDSYDEWVDWDWNEWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCH0</accession>
    <name>A0A317VCH0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_476769</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462874.1">
        <property type="nucleotide sequence ID" value="XM_025608614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCH0"/>
    <dbReference type="GeneID" id="37110757"/>
    <dbReference type="OrthoDB" id="4525861at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY71119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="81" mass="8758" checksum="E877E7AE6E2E1927" modified="2018-10-10" version="1">MGSSTTTSSARLQNDFGADLWVKNTPKRHPTAGRGLFAGLQDMKSYNVESGWAKRSAAENQGFFASILSRFVGGSYKPPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCL0</accession>
    <name>A0A317VCL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RHS repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_527179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462448.1">
        <property type="nucleotide sequence ID" value="XM_025610375.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VCL0"/>
    <dbReference type="GeneID" id="37112518"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.180.10.10">
        <property type="entry name" value="RHS repeat-associated core"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050708">
        <property type="entry name" value="T6SS_VgrG/RHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32305">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32305:SF15">
        <property type="entry name" value="PROTEIN RHSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1603"/>
            <end position="1628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1628" mass="181180" checksum="A37C2E02D7CC7D57" modified="2018-10-10" version="1">MANNNAIYTQGCNFGNLLEKGVDPRTGQYSCAISVWEAPAQARNCPPFKLTLTFNSLDSFDFGLGEGWSFNFTYYDHRKRSLYLSTGERFRVTETSTSVSVPDQKLKSFVFRKLDSGYQLTHKSGQTEILNDNNGTFDKCVPYEIYAANGCLLKPVWGRLGEHPRLVKIQESSQDLLTVDYESTTRKLVRFPDTPEESTFQIRLQANCLERLSLPLTDASWNFDYLKLGQSVCITKVTSPTGLVEEITHKADGHKLPTGAPMSYVPYVTMHIEKPGQSQPAITTRYEFSARNFLGYDGGFRWKDGEDNLYRSRDDYQYSSSVIVDGGSTTTNTYNRFHLIVSSEQKKGYTTVLESIKYYATDHGTFESQPPQCHLPKSIEKKFVDKSSQTPRSRSETTQFEYDEWGNPTKEVRPDGVKVLRTYYPAEGEASNDSADLGCPADPNGFKRYMATESIVPADSDYPAPTRTDKYCYDQIVTADGAKTSYFVSAVQHLSTDGNQILSRTVLAYLNEPTSVNHGRLNQQVTYHLDGFPITKKWNFESQDTNELAIRTSITNFDGTGVKEETVYSTLHGLTLAHKDEAGVEERFEYNLLGQIVKATTSPGTSYETSRSYEYILLQDAKGTQTTVTDAKGVQTRHISDGLERACLVEKQDSDELGSGADYAFSDGFRTVERRNYNAQGQCIEVAEIDWLRSDNGDPIPQESIQQLEYDDWGQVSKTTESNGAVMLSQSDPVDLTETRGIKDEGSTITYRDVSGNDIQIRLCESDGSVYSEVKKRYDGLGRLVEEEDQLERVIKYESDSFDRILTTTWPDGRVSRTTYANHSEDRLPAKVSINNVSLAEQSFDGLGRVTLQHIGPRTVTQTYKGNEPEPVQVTNAQGDECQIKYESALQFVPRSLSRRESTDTYEYDPQSMVPTLLKGAHSTQTREYTSSSRLKHETIELSGAETFFSEYQYSMSGKLQRYVNPHNQTQSVKYDDSGRPACLEQGNIKVSFTYDKASRLSKYSVEENSIVFDFSLAYDEFGREIDRVIRRKEEIVCRLHQTYSQTGLIETRLVKGNEGVSLQEENFKYDDRNRLVEYTCEGTHPPIDGRGNQLQTQIFSFDNYDNIVGMTTSFQDGGHNVTTYTYSKDDPTQLTEITNTNNTYPSQIDLEYDTNGCLTRDEQGRRLEYDSLCRLSTVRDEKENKICEYHYDAAGKLICQLVPDEPNNYLFYRGDSLIATRVGERRISYVSDGKAYWGQIIQDGETEKQQTQLWMADSHDSVLGWLDSHQPDTIHHQSYTPYGLGAHSSIGFNGQWRDPVTGWYHLGNGYRIYNPVLMRFHTPDPWSPFVSGEINPYTYSLGDPSNHVDPSGHFSLFGIHFGWKKLIAAILGLVASIATGILTAGASLAVQVGVGAVAGGVASATGGALGDLAEGRTPTWSSVGKDFLMGAAGGAAGPALGRLGGAVTSRVGKFLGQSPTSYTVSKAIAGHGLQDIVKQSVKGAAKGLVGGQTISLAWEAFNANVIYKRPSQTASKSGSGGESQVSRPEQIRLPYVKVGSSLGRDTIRPLLKNGHNALAGYMIQASASSMSSSYAAKPTSGQSVAEILNLSFRCSFDLSRKERDSEDDSALYSSVRGALRSPADWES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDJ7</accession>
    <name>A0A317VDJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_501632</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462907.1">
        <property type="nucleotide sequence ID" value="XM_025609438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDJ7"/>
    <dbReference type="GeneID" id="37111581"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY71509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="124" mass="14268" checksum="07028D3DE0F4F9EE" modified="2018-10-10" version="1">MASYLLYFLTLSVVVCGTALYLTRFRWLHLVTVPDYIYHRLPSTFAGDVEAGLTSSEFDISANITEGDTRAGLDDQAKREILRIMKRQKVDFNEARRIYIQQRFSKNNIGPDGRPRDPKFVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDM3</accession>
    <name>A0A317VDM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_589626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463248.1">
        <property type="nucleotide sequence ID" value="XM_025615960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDM3"/>
    <dbReference type="GeneID" id="37118103"/>
    <dbReference type="OrthoDB" id="10486512at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY72474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="76" mass="8189" checksum="6D82B4FFC12D4C90" modified="2018-10-10" version="1">MLLDVAAMKDSSKSRPKHWDAGMPVGMLVLVLQPGNAESLLHNNETGKLSQNPRWRSWAGVDGQMATNLKGCAANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDN8</accession>
    <name>A0A317VDN8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_578874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462892.1">
        <property type="nucleotide sequence ID" value="XM_025615235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDN8"/>
    <dbReference type="STRING" id="1450535.A0A317VDN8"/>
    <dbReference type="GeneID" id="37117378"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY71137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="567" mass="63830" checksum="5E3E5BC244BC55CA" modified="2018-10-10" version="1">MSTLLFVATATPVLYLVWVLLTRWQHVQNARKWNCGSMPSYPGDLLGINTLKEALQLDKDRQLPMLTRRRIATLSARENRYTTTFQFRQLGTDIISTSEPKNVQALLATQFKDFELGQVRRNSMHWLLGSGIFTADGDHWSRSRALLRPQFTRDQISDLDLEERHVQLAMQAMPVDATGWTPATDIQTIFFRLTMDTATEFLFGESVQSQAAALSNGAIPQDNFPAQFDRGQWYAAQRARFEKLYWIVDNKESRELNSAVHAYVDRFVNAALSSDPEKKPAHYVFLHGLAEATRDPVELRSQLLNILLAGRDTTASLLSWCVLFLARYPDVFTALRATILAEFGTYTQPHDITFANLKSCRPLQNFLNEVLRLYPIVPGNRRTAVRNTTLPTGGGPSGTDPIYIKKGQSVFYSTFVMHRRPDLWGPDADEFRPDRWSERKVGWEYLPFNGGPRICIGQQFALTEAGYVLVRLLQRFDRFEGVGPTAQGDIKMAVNLTNAPGDNVTPPPDKIPPLNLIEMFAWTGLDSRQGGDVSAVGRYVAYTISCLLAWVGGDEGIAGLRGGYYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDT7</accession>
    <name>A0A317VDT7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APG6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_590042</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462827.1">
        <property type="nucleotide sequence ID" value="XM_025615990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDT7"/>
    <dbReference type="STRING" id="1450535.A0A317VDT7"/>
    <dbReference type="GeneID" id="37118133"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000005">
        <property type="entry name" value="Autophagy protein Apg6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6/beclin coiled-coil" evidence="5">
        <location>
            <begin position="164"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Atg6 BARA" evidence="4">
        <location>
            <begin position="295"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="107"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="205"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY71072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="540" mass="59293" checksum="6ECB8F98D00DF81D" modified="2018-10-10" version="1">MYCQKCRTPLKLDGSLESLNPAAFDLLIGSTGKSIPDHNSNTLSRPHYPQERRELYDRASKHATQPVYRRSIPAPRQAGSNSANPSRLGRSESGNMSFVMLTESQVGLPHGISGTNGDSPSKSKPPISTPSNDRGSEEASFADQVERTSRLFDIISSRSDIDHPICTECTEMLVDGLQQRLVDATKERDAYISFLRNLNTSVPTAEELEAAQKSLKETLDAEKAAFEELLALEQEKAALDEEIAGLEEESRQMDVEEEKFWRDRNTFALTLADFQNERDALNMKYDHDSRQLERLQRTNVYNDAFCIGHDGYFGTINGLRLGRLANPSVDWPEINAAWGQTALLLATIADKLGFHFQGYQIKPLGSMSRIEKIEQSRPSPAQSALSGANAMSTATPKITTLDLFSSGELPLNLPWLHRRFDAGMVAFLECLRQLGEFVEKTPAPVPSNRRGHANTTVPGLKLPYEIKRDKIGDASIKLGFNQNDETWTRACKYTLTCCKFLLAHASNVASAGSSNAAAVAAAAVAAGEQAGMPPASPTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VEM9</accession>
    <name>A0A317VEM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acetamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_550349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462925.1">
        <property type="nucleotide sequence ID" value="XM_025613489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VEM9"/>
    <dbReference type="STRING" id="1450535.A0A317VEM9"/>
    <dbReference type="GeneID" id="37115632"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="78"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY71527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="543" mass="60563" checksum="B59456AF972E3EB2" modified="2018-10-10" version="1">MGSLQPWEQIVSQKRSSRDKLLEPYLVNDVNQRVPQVLSVQERSCVKEDPAVQEITDIDSIPRLFELLKTGQYTAEQATLAYIKRAVIAHQLTNCLTEVVFEDALKQARQLDHDFRQTGQVKGPLHGIPVTLKDQFDLKGVDTTLGYVGRSFAPATEDAVLVQMLKDMGAIVLAKTNLPQSIMWAETENPLWGLTVNPRNPGFTPGGSTGGEAVLLALHGSILGYGTDIGGSVRIPQSLMGLYSLKPTSSRLPYHGVPVSTEGQEHVPSSVGPMARDLSSLCYISRLVANAQPWQLDPKCAPLPWNENSFQEIQNRPLVIGLILDDGVVKVHPPIERALRELSAKLEAQGHELVPWDVSDHLDCIQLMDAFYTVDGGEDIRRDVEAAGESYIPHVEALVNRGKPISVYEYWQLNRKKVTLQKNYLDKWNAARSPSGRPIDVLLAPTMSHPAIPHRGLRWVGYTKIWNFLDYTAVTFPVDQVRAEVDELPADYQPRNELDAWNWSLYNAETMNGHPVNLQVIGKKLEEEKVLGAATVIEKIWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIR9</accession>
    <name>A0A317VIR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Developmental and secondary metabolism regulator veA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Velvet complex subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_239338</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the heterotrimeric velvet complex composed of laeA, veA and velB; VeA acting as a bridging protein between laeA and velB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the velvet family. VeA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463352.1">
        <property type="nucleotide sequence ID" value="XM_025606357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIR9"/>
    <dbReference type="STRING" id="1450535.A0A317VIR9"/>
    <dbReference type="GeneID" id="37108500"/>
    <dbReference type="OrthoDB" id="5384689at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034250">
        <property type="term" value="P:positive regulation of amide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051176">
        <property type="term" value="P:positive regulation of sulfur metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043455">
        <property type="term" value="P:regulation of secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3960:FF:000001">
        <property type="entry name" value="Sexual development activator VeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF14">
        <property type="entry name" value="DEVELOPMENTAL AND SECONDARY METABOLISM REGULATOR VEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="12">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="237"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00064248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY73087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="586" mass="64553" checksum="BE3869E8B2BB5090" modified="2018-10-10" version="1">MATRPPLSPPVNETEHTASRITRDGKKITYYLKITQQPERARACGAGAKSSADRRPVDPPPVVQLHIYESDPKDDRHRTDITFAYNANFFLFATLETARPMAQGRLAPTPTFPVLTGVPVAGVAYLDRPVPAGYFIFPDLSVRHEGVYRLSFHLYEETKDSKDADEGTPILSPVMKVNGSKPSAPRSFLNFRLEVVSVPFTVFSAKKFPGLTTSTSLSRVIAEQGCRVRIRRDVRMRRRGDKRSDDYDFDDDRSYPGPLPDHGSAHDAYPNPAERPRSTSIGSIGPASSYGGEDPRRLSATEYGFPNSQTYPRQVPPAAVPPPSSTPTPVAPIAPSSRSSSYTSHLSFGATRAQYSAPQLPGTPQSATTPTQVYSPHPSYSHTRNPSTSTEVESAPPGYPPSSRLPTERSEYPKLLPPIRTWHHSEPPTNRAVDPFVPRAQTPTNPAFSLPPITSIATEYPNNPSRPPVHIAPKLNNPPQPPNHIAPTAHNPPQPPSHIAPTPNLDRRRNFWETITAASSKRPHEDAFGHSERALYNGMRPDSDLHPNMNRRPSDVHRAAVLNNGEEMAYRRANGRMAIKISPVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VND6</accession>
    <name>A0A317VND6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_474732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463790.1">
        <property type="nucleotide sequence ID" value="XM_025608525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VND6"/>
    <dbReference type="GeneID" id="37110668"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="99" mass="11214" checksum="461F43645B335705" modified="2018-10-10" version="1" fragment="single">PVMMDHGMPDGSRSDRPARPNFRNPSSGPGIKFKRHETASDRQVIFREDKGVQLSCLQPRIGPHPARRGHNRSYQSASASHRPDWVSGRGEWEDVFSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VR56</accession>
    <name>A0A317VR56_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_559399</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464036.1">
        <property type="nucleotide sequence ID" value="XM_025614066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VR56"/>
    <dbReference type="STRING" id="1450535.A0A317VR56"/>
    <dbReference type="GeneID" id="37116209"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY76039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="447" mass="49984" checksum="FD397162430C2BE7" modified="2018-10-10" version="1">MFDMVSHALPLGLYVLVLLCLVRCSILLNKRPFPANAPKFISGYPVVGALRLFFDRGRFCQSSKTASPTGNYSYYLGRQRVVGLSGPQGRKTFFECRDLDLEQGVDLFVPFTSAVEAANDPSIETHISYFRTTVRTALLRTQSLEFIPAAIDACTTSTLNRIKIKGLIDPFQDLSWLYAQSTMAVLGVDEVARSPELSRKLSELVSAIDGTFSAIDMVIPWLLNPFHIPVMIAMGRLYVMMWKIIRNQQQQQPHKRDLYNESMLPSLIEKGRSTRAILKGNSPTVASWLLVGLATNASWMARIRQEVNQVVAKHRKDGESAEQVLRTLNAHAWENEFPLIDACHLESIRLTAGLLLCRKNISPTDVPIGDTGEVIPPGAYVTYHAEEANMDPNIYPYPQRWDPGRFLSDRAEHLKEPLAYAGFGAGRQKCLGENSNVHASGEIRHHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VS97</accession>
    <name>A0A317VS97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_588599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464451.1">
        <property type="nucleotide sequence ID" value="XM_025615894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VS97"/>
    <dbReference type="STRING" id="1450535.A0A317VS97"/>
    <dbReference type="GeneID" id="37118037"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY77264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="580" mass="64261" checksum="EA122802850754DA" modified="2018-10-10" version="1">MADQKPSPVACVPCRRRHLKCDARMPVCTRCHNTNNDCRYVRSRRGLRNRSSPDPGDLDLPDFTSWLNGSLDIDPELLDLPDLDVSVDIHSDSIPSPPEFISAVADSEPLAHDAMIQLYYHHFHRSHPILLPRRSLASPLCQQIPAYIPHIMRYIGSHYYPHPGFSDSFHTSAYTVLSAPNDGYKVQGLLLLAIIEHASGGEEKARKLLHEAIQLACRLGMNSTSFARAHSCGSPILEESWRRTYWELVVVEGIISALSGAILPSQKWINNEMQLPCDENAYNAEPPSLSTLPDPDMHHISSFTHRILAIQNLRAVLQITQCLDPDTEFRTETLDARLATSLMRLPSSLPDHDASTVDEMAFQTLMITYLSLIYLHHPHSTIRLSAYHATTINSTSSILPPTSTSTSTSCTRVHASPISCANTHITQRTPNTNTHNQKLLRAADLLSNLATLPSSVISRTPFFTCGLAIAVVVHVAALVGRNSPLSLKNHNTTESRDRERAKEDSLKARIELGYNQLTSQEQPAAAAHTRRVGVIGYKTLRFLPFVFVIFATFASSSLGNVIPQIEYPDGSLVLGLFPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSE6</accession>
    <name>A0A317VSE6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_559135</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Gamma-glutamyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464443.1">
        <property type="nucleotide sequence ID" value="XM_025614043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSE6"/>
    <dbReference type="STRING" id="1450535.A0A317VSE6"/>
    <dbReference type="GeneID" id="37116186"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000008">
        <property type="entry name" value="Gamma-glutamyltranspeptidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="796"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="814"/>
            <end position="816"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="838"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="866"/>
            <end position="867"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="889"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY77256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="986" mass="108178" checksum="30FBB12D97613961" modified="2018-10-10" version="1">MPSRRSHTKSRKGCLQCKKRHVKDPPDVTPGPDGDALSTRMLEMRLFHHYVTETYITLCQGRLDANHFQVVIPRIAVAHPFLLDSLLALSALHLAYLETHDNHSWLEVALKYQNRACSAFSRVLAEMSPANCGPAFICSIFIMLCATAYPCVTQDRQTFEPLSHVLEIRQLIAGCAFLFEQLNGMEYRGDLQGWLKYKDDEVDQDGNPYSAILKSMQRVHVKYTSLGGPHQATYQGTWNILHEAIKRWPFGGPNGGVIAWPINIGEDYIALLQSGDWVARVLFLHYGVGLHLLSDKWFVRDWGRRLIETVLQAEEDVPSIWAETITWTREASQFGLRRIRIPFSCNMQSNQPNQHLSQDAEKQPLLGPLETPVAPSRLGLSHDKRLSPPTMFRLMKFTVLSTLLLTVLVIQLPSVLTSPLDFATRQLVREDGLEDGKRGAVASESAICSRHGTDIITMGGNAADAVRTSELDWSLLWRYANPNPADGGHNALRMYHSGIGGGGFMLVKTPDGSFEFIDFRETAPAAAFEDMFNNNTNAATIGGLASGIPGELRGLEYLHSKYGSLPWSTVVQPAIQTARDGWSVGQDLIRYMEAAVGDGEDFLSRDRTWALDFAPNGTRLGLGDIITRKRYAATLETIADQGPDAFYSGPIAKTMIDAVQAANGTMTLEDLAGYTVAIRNVSQIDYRGYRITSTTAPSSGIVAMNVLKVLGTYDNFFGSDTLNLSTHRMDEAIRFGYGLRTNLGDPSFLDDMDKYQAMMLADSTIGEIRGNISDLQSQAVSAYDPEGLESLETPGTSHIATIDHSGLAISAITTINLLFGSQVMVPETGIIMNNEMDDFSIPNSSNSFGYIPSEANFIRPGKRPLSSSTPAIVTHPNGTVFFVAGSAGGSRIITATIQNIIHAVDQGLSAAEALIQPRLHDQLIPNHVTFEYTYDNETVSFMAARGHNVTWVAPGQSTAHAIRVLPNGTFDAAGEPRQADSGGFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VT06</accession>
    <name>A0A317VT06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_499417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464069.1">
        <property type="nucleotide sequence ID" value="XM_025609375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VT06"/>
    <dbReference type="STRING" id="1450535.A0A317VT06"/>
    <dbReference type="GeneID" id="37111518"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF1">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY76072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29914" checksum="3015D7158CCE64C4" modified="2018-10-10" version="1">MARDNTHYQQFPAQESDPLLGPRHGSKSSPLGRLRHHLRTEIDPHRADLLLIFCYVITGLLDSSAVFIWGSFVSMQTGNTVYLGLGLAGMDDTQRWLKSLISISSFCIGSFFFALFHRLFRTPRQRSALALSFTLQMICVTIAASIVTVHQTGKNDLLSWKIAVPLALVSFQGSGQAVTSRVLKFSSLTSVVLTSIYCDLFSNPALISPSVVKDPDEWRRAGAVLGLLLGTLLGGVWAKSEVGLPGALWTAVFFKGLIAVAWLWWKGKDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VT12</accession>
    <name>A0A317VT12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_538328</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464264.1">
        <property type="nucleotide sequence ID" value="XM_025612468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VT12"/>
    <dbReference type="STRING" id="1450535.A0A317VT12"/>
    <dbReference type="GeneID" id="37114611"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="113"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY76451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="304" mass="33338" checksum="F0E7EAFF2AA88AFD" modified="2018-10-10" version="1">MESEAFEDMQKGGGSLRMVKDLGAGAAGGIAQVLLGQPFDIVKVRLQTTTQYSNALDCATKIFKKEGPFAFYKGTLTPLIGIGACVSVQFGAFHEARRRLEKLNKKKYADSTLSYSQYYLAGSFAGLTNSVLSGPIEHVRIRLQTQPHGADRLYNGPIDCIRKLCNQGGVLKGLFRGQNVTYLREAQAYGTWFLAFEYLMNQDAKRNNIKREDISSLKVATYGGLAGEALWLSSYPFDVVKSKMQCDGFGAQQQFKSMTDCFKKTYAAEGFAGFWKGIGPTLLRAMPVSAGTFAVVELTMRALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VT42</accession>
    <name>A0A317VT42_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_605178</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464005.1">
        <property type="nucleotide sequence ID" value="XM_025616472.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VT42"/>
    <dbReference type="GeneID" id="37118615"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029226">
        <property type="entry name" value="Ecp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF1">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14856">
        <property type="entry name" value="Hce2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016359978" description="chitinase" evidence="12">
        <location>
            <begin position="38"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="320"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="384"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="524"/>
            <end position="891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY76008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1503" mass="160219" checksum="CCCC689B80135861" modified="2018-10-10" version="1">MSFSSPFSAWLRPRNPFLTLLSLVLVTLSFSIHTSSAITVPVRLPASLGYQGRSAACPARCAVSGPNPANWSLYHNFDQLALCDESLFYSFSFVDPVDDPDTAHRIYTCTSFGPDWANLPANTSSLVSQSEGAPAPVNGTYQIGSWPSTPGSSVSSSLATLTKQFRQYLSNGFGAGNHPTILFASYGSTSVGLYIGQGLQSQGIGNIALAYLENTMATSNTSLSASVAMQFCQPGQTSHHVFGLMATGNGMFATVQDALSSWSKAECLAIPSVQNVTGTVPLATPLLSSSTKTLSPNSTSTYANVTSIRGRALAPRTTCSTVQVVSGDSCSTLAQKCGITPAQFTKYNPESNECSSLTPGEHVCCSAGTLPDFAPKPQANGTCATYTIQPDDSCSTIAATYSITVDDINEFNNDTWAWNGCSCLYPHNVICISTGNPPMPAPVANAICGPQVPGTPTPPSGTNISLLNECPLNACCDVWGQYGTTAGFCTKTGTGAPGTAANGTNGCISNCGTNIVLSSAPVTYRSIGFYEGFNLQRPCLYQDISQLDISAYTHIYFSFGVLSSSYEVQIPNVTTTYEFNLFKELQGVKRILSIGGWAFSTDPSTYMIFREGVTATNRLTMATNIANFIKDNDLDGINIDWEYPGAPDIPGIPAASTDDGDNYLAFLAVLRNLLGDKEITIAAPSSYWYLKGFPIKKMAPLLDYIIYMTYDLHGQWDSNNQWSQLGCPTGNCLRSDVNLTETIGALVMITKAGVPSNQVVVGVTSYGRSFAMSEAGCYGPQCTFLGSADDSQAAPGPCTQTAGYIANAEIEAILANSSRVTQSYIDPTSNTNILVYDETQWVGWMSDGVKASRKSLYKGLAMGGTTDWATDLQKYNDPPFIAKSWEALIDDVVLDKDPYEEGNRTGNWTSLTCSDPAIQDALWMPCAQRWAQLDASNAWSDAINVWKNIDKPRMSGVEKDFSISIMNTFHGGENTYCGIVAPRGSCFTSQTCGWFQGFGQGTGDSGAAAMAIYDSLTAYSQFHAAIDAVAGTYIDTQLQYFETTFSPVPPTESNTWLEILLNLVGLGITAVAGPFFDDIYESLPALVGDANTATSLTSATVAYGVSITTDVLPTDAPGQWSATSQESFTATLGSVVSGWAAIAENQLWYLFNGSDASISLLTSMITNGNLMEGSGGSPSVSHKTDPQTNARIEGYISKAFFGFAIPSVWEVSGTAAFVLDSGYDCSAQNPLTEYMTNATQEATYACYKDKLYYLVYPDGKWSGCTDEEIAKIDCNDCGGSTSTCGDDATYFTAPPGLSDLGPGLWGNITLAELIEGSVRTYEANGNANGGPVANPMDKDTLHDLSNQDITTPGYIRLPVCSAQVAWASWSNPSQSNSSAQYYPCNPLQGITKCSGYTYQDETSSASPKVSDCQTIIKNIQGTNGEWTTGIDHQRDIAKFGTCNFGVQNVGVTGDVTYHTGSQDIVNIITEAISMYASNGLVGAKGYMKCDGNTGSQKVEWGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW08</accession>
    <name>A0A317VW08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">EXS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_538069</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464394.1">
        <property type="nucleotide sequence ID" value="XM_025612412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW08"/>
    <dbReference type="STRING" id="1450535.A0A317VW08"/>
    <dbReference type="GeneID" id="37114555"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="189"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY77207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="402" mass="46322" checksum="2E8900D78CCD7528" modified="2018-10-10" version="1">MGPDQHAQLDGFSLFLPFPYRVAVILLAGFWGWGANLQYLLKANIDVPALIKYPARQSSSQRPHHASTYQLATLLTIPLAISLLVFWPVTHGSAQRVESVEFIPQSYFFIGLFILLLPFYRIARSGRYRFFMTLKRISLGGLAEAQDGKFGDILLADALTSYARVLADLVVTFCMFFTTDISSTSKPTRKCRQNDYVVPLIIALPSMIRLRQCLIEYLRVRRAGPRSHGLGGQHLANALKYATAFPVIILASQLKHYSPLDFYGYSEMSLSRLLFFFMFINSGYSFYWDITKDWDLTLLTPARHSHEYPYGLRRHRYFTDRQYYIAIAADLAIRFSWLSRYVPGFLWLSDTEFGLFVLMFLEVARRWMWNFLRIETEWIRNSRGPAPDDILLGEFGGKLDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWT1</accession>
    <name>A0A317VWT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Increased loss of mitochondrial DNA protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_538243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464193.1">
        <property type="nucleotide sequence ID" value="XM_025612448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWT1"/>
    <dbReference type="GeneID" id="37114591"/>
    <dbReference type="OrthoDB" id="5299849at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018815">
        <property type="entry name" value="Incr_loss_mito_DNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029:SF1">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10311">
        <property type="entry name" value="Ilm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016348473" description="Increased loss of mitochondrial DNA protein 1" evidence="2">
        <location>
            <begin position="28"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY76380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23373" checksum="A6117746C09F277D" modified="2018-10-10" version="1">MALLSSKTLIQAHALFLFVLAVYLTRSPEVVTESDVVFMLGEFLNLDASPSLSRPQSPFALCGVLLVLDALVDLVLVSKVPQINEIIAMAQAARIQSPIPVAGAIRTNPFMARLASLYSEIWTLLSASRFCIFFAVSFFIYQSQPAAWGMDAASVMGSYGSAGVATSGLDQLKNRVVFTYGFMEMMFWLWIFITLREERQEAAARFVEHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWZ0</accession>
    <name>A0A317VWZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_537895</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464621.1">
        <property type="nucleotide sequence ID" value="XM_025612372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWZ0"/>
    <dbReference type="STRING" id="1450535.A0A317VWZ0"/>
    <dbReference type="GeneID" id="37114515"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 11" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY78109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="521" mass="57971" checksum="FF621E2B7DE993C3" modified="2018-10-10" version="1">MAAKVLPSHLRAPASDATSGASFGKHHGKTQSHMAFENASTSVAASQMRNALNALAETVTDEDERKRFEAEMDNFFALFRRFLNDKAKGNVVNWDRIAPPQPSQVVDYAELGSEASVEFLNKLAVVKLNGGLGTSMGCVGPKSVIEVREGMSFLDLSVRQIEHLNRTFNVNVPFVLMNSFNTDQDTQSIIKKYQGHNVDIITFNQSRYPRIIKDSLLPAPKSFDAPLQDWYPPGHGDVFESLYNSGTLDKLLERGVEYIFLSNADNLGAVVDLRILQHMVDSKAEYVMELTDKTKADVKGGTIIDYEGKARLLEIAQVPKEHVNEFKSIKKFKYFNTNNIWMSLRAIKRVVEENELEMEIIANEKSIPADKKGEADQAIYQLETAVGAAIRHFKNGHGVNVPRRRFLPVKTCSDLMLVKSDLYRLEHGQLVMDPNRFGGVPVIKLGSDFKKVSDFQKHIPSIPRIVELDHLTITGAVNLGRNVQLKGTVIIVATEGSTIDVPPGSVLENCVVQGSLRILEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXB2</accession>
    <name>A0A317VXB2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Glutamate synthase [NADH]</fullName>
            <ecNumber evidence="19">1.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BO94DRAFT_177016</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Forms L-glutamate from L-glutamine and 2-oxoglutarate. Represents an alternative pathway to L-glutamate dehydrogenase for the biosynthesis of L-glutamate. Participates with glutamine synthetase in ammonia assimilation processes. The enzyme is specific for NADH, L-glutamine and 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="24">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="24">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-glutamate biosynthesis via GLT pathway; L-glutamate from 2-oxoglutarate and L-glutamine (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Energy metabolism; nitrogen metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.14" evidence="19"/>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464734.1">
        <property type="nucleotide sequence ID" value="XM_025605945.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VXB2"/>
    <dbReference type="GeneID" id="37108088"/>
    <dbReference type="OrthoDB" id="4327079at2759"/>
    <dbReference type="UniPathway" id="UPA00045"/>
    <dbReference type="UniPathway" id="UPA00634">
        <property type="reaction ID" value="UER00690"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016040">
        <property type="term" value="F:glutamate synthase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019676">
        <property type="term" value="P:ammonia assimilation cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097054">
        <property type="term" value="P:L-glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00982">
        <property type="entry name" value="gltB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00713">
        <property type="entry name" value="GltS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000160">
        <property type="entry name" value="Glutamate synthase (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000006">
        <property type="entry name" value="Glutamate synthase (NADPH/NADH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000031">
        <property type="entry name" value="Glutamate synthase 1 [NADH]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000017">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000113">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000022">
        <property type="entry name" value="Glutamate synthase [NADH], amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.60:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000001">
        <property type="entry name" value="Glutamate synthase, large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="entry name" value="Glutamate synthase, alpha subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012220">
        <property type="entry name" value="Glu_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006005">
        <property type="entry name" value="Glut_synth_ssu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051394">
        <property type="entry name" value="Glutamate_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01317">
        <property type="entry name" value="GOGAT_sm_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008730">
        <property type="entry name" value="PRK11750.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43100:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000187">
        <property type="entry name" value="GOGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="Alpha subunit of glutamate synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 24" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0288">FMN</keyword>
    <keyword evidence="17" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="13" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16 24" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="26">
        <location>
            <begin position="53"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="960"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1563"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="972"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1579"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="23">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1184"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1190"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1195"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00057049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00068518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000187-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PWY78425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2126" mass="234111" checksum="7E1A7EC62860451C" modified="2018-10-10" version="1">MGLNLEEIYGKSIVDEQKPQEYSEYQPKKGYGWANTLPERQGLYDPEYEKDACGVGFAAHIKGKPSHKIVSDARNLLCNMTHRGAVGSDARDGDGAGVMTSIPHKFFIKNFAREVGVDLPPLGQYAVGNLFFKPDEESVKESVENFEKIATSLGLRVLGWRDVPRDSTILGPAALSREPTILQPFVVLKSAYGEGNKPEITDPESFDEKTFERQLYVLRKRATHIIGLANWFYLCSLSNRNIVYKGQLAPVQVYQYYHDLVNVDYEGHFALVHSRFSTNTFPSWDRAQPLRWAAHNGEINTLRGNKNWMRAREGVLKSDIFGEELDSLYPIVEDGGSDSAAFDNVLELLMINGVLSLPEAVMLMIPEAWQDNPAMDPSKAAFYEWAACQMEPWDGPALFTFSDGRYCGANLDRNGLRPCRFYVTDDDRIICASEVGAVDIDPERVVQKGRLQPGKMLLVDTVAGRIIDDSELKYTVSHRHDFASWLDKELLKLPAIKDRLDEQSVGLTYALDDTTIQNDPRLKAFGYSFEQVSLLLGPMAADSKEALGSMGNDAPLACIAKQPRLLYEYFRQLFAQVTNPPIDPIREAVVMSLECYVGPQGNLLEMEQSQCHRLLLPSPILSIPEFNALKNIAQAHKDWTVKTIDITFEKKKGVPGYLEALDAICDATTEAIQNGDKILVLSDRATGDDRVPVSALLATGLVHHHLVRNKWRSLAAVVVETAEAREVHHMCVLVGYGADAINPYLAMECILKMNREKLIRKQLPDEKVIENYKASCDGGILKVMSKMGISTLQSYKGAQIFEALGIDDSVIDRCFSGTASRIRGLTFELIAQDAFAFHDRGYPSRGIVDIPGLPESGEYHWRDGGEEHINDPVSIANMQDAVRTKNDKSYEAYAKAAHEQIKNCTLRGMLDFDFEQRTPIPIDQVEPWTEIVRRFVTGAMSYGSISMESHSTLAIAMNRLGGKSNTGEGGEDPERSNRLENGDTMRSAIKQIASGRFGVTSHYLADADELQIKMAQGAKPGEGGELPGHKVVGPIARTRYSTPGVGLISPPPHHDIYSIEDLKQLIYDLKCSNPRARVSVKLVSEVGVGIVASGVAKAKADHILISGHDGGTGASRWTGIKYAGLPWELGLAETHQTLVLNDLRGRVVVQTDGQIRTGRDLAVACLLGAEEFGFATTPLIAMGCIMMRKCHLNTCPVGIATQDPALRAKFQGTPEHVINFFYYVANEMRAIMAKLGVRTVNEMVGRAELLKVREDIRNAKQEKIDLSLILTPAHSLRPGVATYNVRKQDHRLHTRLDNKLIAESELALEKGLPCRIECDIVNTDRGLGATLSYQVSRRYGGEGLPQDTIHANIKGSAGQSFGAYLAPGITLELEGDANDYIGKGLSGGRLIIYPPRGAAFKAEENVIVGNTCLYGATRGTCFFRGMAAERFAVRNSGATAVVEGVGDHGCEYMTGGRVLVLGSTGRNFAAGMSGGIAYILDMNQDFHSKVNMEMVEVSGLEDPAEIAFVRGLIEDHHHYTGSELAARILLDFTRALPHFVKVLPTDYKRILEEEAAKAEAAKKAEFSLPQLPSTPIPAEKPKAPEGDAKKAEMLDIEDSISDSKTEKKRSALILDKTRGFMKYSRRKEKYRNPATRTRDWAELSNRLSEDELKYQSARCMDCGVPFCQSDTGCPISNIIPKWNELVFQNQWQDALNRLLMTNNFPEFTGRVCPAPCEGACVLGINEDPVGIKSIECAIIDRGFEMGWMVPRPPKTRTGRTVAIIGSGPAGLAAADQLNRAGHTVTVYERADRIGGLLMYGIPNMKLDKKVVQRRVDLMAAEGVQFAPGTPVGPDHEVTLESLRQTNDAVIIATGATVARDLKVPGRELDGVHFAMQFLHRNTKSLLDSNLADGAYISAKDKHVVVIGGGDTGNDCIGTSVRHGAKSVTNFELLPQPPPERARDNPWPQWPRIYRVDYGHSEVKTHMGKDPREYCVMSKEFVDDGNGRVRGINTVRVEWTKSASGGWDMKTVEGSEQFFPADLVLLSMGFLGPEDRVLGEGIERDARKNVKTPPGQYSTNVSGVYAAGDCRRGQSLIVWGINEGRQCAREVDSFLMGISSQLPVTGGIVRRPAIDTVPQVAQQTVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYE6</accession>
    <name>A0A317VYE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_537400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464956.1">
        <property type="nucleotide sequence ID" value="XM_025612258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYE6"/>
    <dbReference type="STRING" id="1450535.A0A317VYE6"/>
    <dbReference type="GeneID" id="37114401"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="12">
        <location>
            <begin position="51"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="11">
        <location>
            <begin position="166"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="10">
        <location>
            <begin position="282"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY79384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="401" mass="43861" checksum="7023BAAB6C84087C" modified="2018-10-10" version="1">MNPSVFRTASRHFQSANRLCRASAASRNASVRGYATAFNWEDPLVTSDLYTEEELAIQDTARQYCQERLLPRVLDAYRNENYDRQILTEMGELGLLGASIEGYGCAGVSTVASGLITKEVERVDSGYRSGMSVQSSLAMTAIHDFGTQELKDRLLPDLAKGKLAGCFGLTEPNHGSDPGSMETVAREHPTKKGYYLLSGTKTWITNSPISDIMIVWAKLQTTGKIRGFVVERSQCPPGTMETPAIKNKTALRASITGMIQLDDCPVPAENMFPEVQGLAGPFTCLNSARLGIAFGAMGALEDCLSRARTYALERKQFKGNPLAKYQLIQKKLADAATDAAYGTLAATQVARLKDAGKCTPEMISMVKRQNCDRALANSRMYASPFSCLLCLRHDIFYKTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYX5</accession>
    <name>A0A317VYX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_537971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464679.1">
        <property type="nucleotide sequence ID" value="XM_025612388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYX5"/>
    <dbReference type="STRING" id="1450535.A0A317VYX5"/>
    <dbReference type="GeneID" id="37114531"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="347" mass="37571" checksum="C43A49C33B39E1E6" modified="2018-10-10" version="1">MRAIQVREYVKGPLDLQVATLPTPSPSATEYLIEIHSAGTNFFDLLQIQGKYQHQPPLPWIGGVEFAGTILAVPTATQASLRFRVGDRVFGATQGAYATHILAQEHTLLPVPAGWSFEDAAGLFVTAPTSYCGLVHRANVQPGDWVLVHAAAGGVGLAAVQIAKAKGATVIATAGTERKRQVARQFGADHVIDYREKSWPEEVKRLCAQYRTGNGKDGVDIVYDPVGMIEASLKCVAWNARLLVIGFAAGKIEKVALNRVLLKNVSLVGLHWGQYARFEKETDQAVWRGIFDIVTQGKFKGTAFIDESFVGLESVPRALQALGGRETWGKVVVKIIDDDAAVAKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZB9</accession>
    <name>A0A317VZB9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538101</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464427.1">
        <property type="nucleotide sequence ID" value="XM_025612421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZB9"/>
    <dbReference type="GeneID" id="37114564"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY77240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="53" mass="5570" checksum="ED55DDA5DA82CCCF" modified="2018-10-10" version="1">MDDGTLDQGRQAGGVTKKGGGEYLGFWLPINGNMSTMGGEVQLLNLLSSWAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4C3</accession>
    <name>A0A317W4C3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_558240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465431.1">
        <property type="nucleotide sequence ID" value="XM_025613994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4C3"/>
    <dbReference type="STRING" id="1450535.A0A317W4C3"/>
    <dbReference type="GeneID" id="37116137"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="183"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY80829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="379" mass="43700" checksum="31FAC13D18DDE005" modified="2018-10-10" version="1">MISSLFRPASPSQNAPTYFDIRLDTNVIWLPGDDIPTGYCHLTSKVILCLNQPLCIKDLKLHFEGWRYLKWNPHFSYFETHHQKSTLWERLFMRQTWNFLQCSKTSTSTTLPPGNHEFPFHFCLSSKTSDSVQGLNDCSIRYNLKAQIRTLKDSTFDTAKHITVCRIHRSLLFPEPKILQNIWPDKIIYRAQSPSTTYTFNGTIPLTFHFVPLRKGLKIASIHTQVIETHKAIQPSLSTRSRIIIQDDFNVPSCDELETTSDDEGYWHHLNRLLRLPKGLRKCVQSTANSFLRVDHELEIQIRLVNPDGHESSINLTWPIFIYFPLPQELGDGYASSLIKALRMVDETLDLSLPNYNDHVLDRMPDDVPDGLGCRGYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W575</accession>
    <name>A0A317W575_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FMN binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_567358</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465333.1">
        <property type="nucleotide sequence ID" value="XM_025614625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W575"/>
    <dbReference type="STRING" id="1450535.A0A317W575"/>
    <dbReference type="GeneID" id="37116768"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04733">
        <property type="entry name" value="OYE_like_2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="15"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY80731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="416" mass="44926" checksum="1A6906EFC6E1E2DC" modified="2018-10-10" version="1">MTSIISQNLTLKCGLQLENRLVKAAMAEHMADGNSLPTELHDRAYAEWGRGGWGMLLTGNVQVDRMYLGGAGDNTVNPAIEDELIRRWKSWAAASTSHGTPTVMQISHPGRQSPLGAGARCMFAKNVSPSAIPLDLGSGLMAKLTSAVVFGTPREMTQNDIDHVIQQFVYTARLAHRAGFQGVQLHAAHGYLLAQFLSAKTNRRTDSYGGLSAGRVKIVLEIIHAIRAAVPATFGVGIKLNSVDHQSKSELNSCIEQLKLIVEAGVDFVEISGGTYEDPRMMGATPQPVPEKSARTVAREAFFLEFARAIRAEFPGIPLMVTGGFRTRQGMEKALADGDCDMIGIGRPAVLHPTLPNDILLNADVPEERARLITQPISPSRLIKMTGIKSAGSGAESRWYSNEIQKMARSAARSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6Q3</accession>
    <name>A0A317W6Q3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_558092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465703.1">
        <property type="nucleotide sequence ID" value="XM_025613983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6Q3"/>
    <dbReference type="GeneID" id="37116126"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="83"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="218" mass="25060" checksum="ED3570A7DCE46A02" modified="2018-10-10" version="1">MTETRTMCCTCLTLHNPWRPSTGCPLKLEFATIDDVPELTQLWYNAFSPSMLKVWPDTPGVRQWWESANRHDMLNKPCEKYLKVVDPNNEGRIAAYAKWSLETAEERGPRYPSWHPDMDAHHNDAFFQPLKGSRARLVGGGRRNFYLDMLATHTDYRRRGAARLLLEWGCEVADQENFPIYIDSSEEGRPIYERFGFVAQSTTGGLASMVREPRATEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6R4</accession>
    <name>A0A317W6R4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_425393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465807.1">
        <property type="nucleotide sequence ID" value="XM_025607438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6R4"/>
    <dbReference type="STRING" id="1450535.A0A317W6R4"/>
    <dbReference type="GeneID" id="37109581"/>
    <dbReference type="OrthoDB" id="5422579at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="489" mass="57221" checksum="C4F7A5BFBD9657E0" modified="2018-10-10" version="1" fragment="single">TLSCLPSELLLIVASYLPNRDIKNLRLTARFLHDTVRLRLDRVFLSANPLNISVFRAIADDERFRQGVVEIIWDDAVLVETRSEADFSLWGLWSPLSPRMFEDHPEEQCPVWFAKACRSNLKRLFHHKHNDVDGPDHMARALQVVAAQRALIYFWEYYQRLLIGQKWVIETAADTDALIYGINQFPALKRVTVTPAAHGWLFAPLYETPMILSFPYGFNYPIPRGWPTTNEGLSLNVPSWASLSNHRKDQWRGFRITTRVLAQQRENHVTEFILHTNQLYTGLNCRIFEESCEEYDNLICLLRQPGFSRLDLALITDQQEDLDWYSFYNGRLRYALAQATQMRHISLTGNMKNHVVYANDSYNEDDNDTTSHLIPIRTIFPIEKWTNLQHFELSSFVITKDDMVSFLAALPKTICSIKLRRLNFFKKSDHWPGLLIDIRDKLHWRERDIKSRPKLTIIIDKVLATPPWWAIWIEDEVSKFLYENGPNPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6W3</accession>
    <name>A0A317W6W3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_548043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465350.1">
        <property type="nucleotide sequence ID" value="XM_025613374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6W3"/>
    <dbReference type="STRING" id="1450535.A0A317W6W3"/>
    <dbReference type="GeneID" id="37115517"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="344" mass="38123" checksum="8BB81BAF5C2A22E4" modified="2018-10-10" version="1">MTTLPKIFITGATGYIGGDALYALFAKHPEYIYTALVRTPEKAQKVQAQYPSIRVIIGDLDDSSLLEKESAEADIVLHTADASDHEGAARAIATGLEKGHSRERPGYWLHTGGTGILTFHDTDRNVFGEYSEKVYDDWDRVEELLNLPDHAFHRNVDRVVLETGRTKKGVVRTALVCPPTIYGRGRGPVSQRGRQAYELAKVTLRLKKGPIIGEGKATWNNIHVHDLSELYVLLAEAAVQGREDPELWGERAYYLTENGEHVWGELAKAMAQTAVELGLLSEAKAGVISLEDAKKYAGYESLSWGMNSRGRARRGAKVLGWTPSRPSLEATLPEILEDEVERMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9F3</accession>
    <name>A0A317W9F3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_469425</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466021.1">
        <property type="nucleotide sequence ID" value="XM_025608288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9F3"/>
    <dbReference type="STRING" id="1450535.A0A317W9F3"/>
    <dbReference type="GeneID" id="37110431"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="264"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="416"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="495" mass="53642" checksum="96821A998C3D1E67" modified="2018-10-10" version="1">MMSQSGYSVSNQFGNPNEGVDPSDLSMQGSGFMTYPFTSQQNFNFGNSGIDTDELLDLEINGQNGMQQNYMQDQHSSAGMSMSHPGQMSQMFSNTPEGAPMHSPFMHSFNYDHFRNMSQPGQPGSHLQSGSHFEQSYLSSKGRPSLQAVDRASLDARSPMTPKTPALGGLTLGTPESGSFPTQPIRTGLQHRHQKTLSNQWDGTPGSAHSFVESPISSPGHPSHHAGISEILKSGKHASLPAKVDAHMPGSAQDLESQEAKRRRRRASHNLVERRRRDNINERIQDLSHLVPQHRLEDDKVRKQLVNNTAMSATGAPSNAATSLLAGGNGRRATAGNITMGLPIEEKEKGPNKGDILNGAVGWMRDLMWALHVKLQQESELAELISSLGGTWPFEQTEEEKRMRTEILDALEKNDPTSFSYSRAPGSGLRVPKHTNMAGDSVAGNGALSPQSLSPPFNSGGSSNGGGSGQAQYWSSSGHAGMSFKEEDEYAMEMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCR7</accession>
    <name>A0A317WCR7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="9">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="9">MTA phosphorylase</shortName>
            <shortName evidence="9">MTAP</shortName>
            <shortName evidence="9">MTAPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_557568</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-methyl-5'-thioadenosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="9"/>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466173.1">
        <property type="nucleotide sequence ID" value="XM_025613935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WCR7"/>
    <dbReference type="STRING" id="1450535.A0A317WCR7"/>
    <dbReference type="GeneID" id="37116078"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000040">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000634">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1580:FF:000008">
        <property type="entry name" value="S-methyl-5'-thioadenosine phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="3 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="5 9" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="197"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="563"/>
            <end position="564"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="596"/>
            <end position="597"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="698"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="722"/>
            <end position="724"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="9">
        <location>
            <position position="680"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="9">
        <location>
            <position position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY83705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="806" mass="88801" checksum="931D90DF05B4644D" modified="2018-10-10" version="1">MPSQNDRSHSFKRIGIVGAGNMGSMMSLAFTELGLDVSIWDAKRENIDGIKKWCDEGKFKGKGKVEGFYEIDKFTKSLEGQGERKLFIFSITHGDPADSVLDMIKDDLKKGDIILDGGNENYRRTEQRQKRCKDLGVSWIGMGVSGGYQSARHGPSLSPGGDPEALELVLPLLEQYAAKDEKTGLPCVTNVGPAGSGHFVKMVHNGIEGGMLSTTAEAWAILHYGLGLKYEEIADIFEDWNKKGELRKNFLLDIGVQILRTKKTPQGDQNGEGASQDDGYVLNDVLDKVVQDDDDTEGTPYWSVMETANRHVAGPTLATAHYMRIASGNRAERLKVAQKLNIPDPKPIEVKDRKDFVEKLRRAVYCSFLASFCQGLELIARASKDEGWNVDLSKCIQIWRGGCIIQSEAIADLLQPAMKVDLTNMKFVDEIARELHKEWDALKEIVLAATVADQYIPAISATLEYLKYEGGTMLPTKFMEAQMDLFGAHAYYKPGVPGEDPGPRRPVRIAVIGGTGLSELPGFTQVASLNVSTPWGNPSSPITILHHQCSHNQQTVAVAFLSRHGLHHQIAPHEVPARANIAALRSIGVRTIIAFSAVGSLQEEIKPRDFVVPDQVIDRTKGIRPFTFFEGGVVAHVPFGDPFDEGVAKVVRACGHSLEGEGVVLHDRGTLICMEGPQFSTRAESKLYRSWGGSVINMSCLPEAKLAREAEIAYQMICMSTDYDCWHESTADVTVEMVMGNMKANAINAKRFVTAVLDELAANQNSELVQAKHIEGSIKFGLSTAQPNWSPESREKMNWLFPGYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD98</accession>
    <name>A0A317WD98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_598231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466421.1">
        <property type="nucleotide sequence ID" value="XM_025616284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD98"/>
    <dbReference type="STRING" id="1450535.A0A317WD98"/>
    <dbReference type="GeneID" id="37118427"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000003">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000016">
        <property type="entry name" value="Oxysterol binding protein (Osh5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY84496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="415" mass="46128" checksum="29EBBA2CC72113B6" modified="2018-10-10" version="1">MSSSKDPQSGVPANSKGSWTSFLKSIASFNGDLSSLTAPPFILSSTSLTEYSAYWAEHPGLFVAAAREADPEKRALAVLKWFLSTLHQQYCSRSEKLGSEKKPLNPFLGELFLGKWNSDADVGETTLISEQVSHHPPATAYAIRNEKHGVELQGYNAQKASFSSTIQIKQIGHALLTLTPPGADKNDTAQQERYLITLPHLHIESLIYGTPFVELEKSTRIASSTGYVAKIDYSGKGWLSGKKNTFSAILYKENEGEKKPLYTVDGQWSDSFVIKDSRKHEVDRFSVKDTKTTPLTLAPIDEQDLYESRRAWRDVAVGIERGDMDAVSVAKSKIENAQRELRKVEKSEGREWDRRFFKRVNDNDDDGFWKLARMLGITSLESEKTGGVWRFDAANAVNAQPPYHKTGGEGLGVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDG8</accession>
    <name>A0A317WDG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_118485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465883.1">
        <property type="nucleotide sequence ID" value="XM_025605558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDG8"/>
    <dbReference type="STRING" id="1450535.A0A317WDG8"/>
    <dbReference type="GeneID" id="37107701"/>
    <dbReference type="OrthoDB" id="4509729at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="109" mass="11827" checksum="999DF2AE18AA3658" modified="2018-10-10" version="1">MTSPSKTHHQPAASSNKVPSLHTIQPMKRSISYSPAQDDEHIASSKASESRGSDHMVKAALMELLNDDGVKASARGSRSVQNLLMDTEKALRKQRRESLSGRASISVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDL0</accession>
    <name>A0A317WDL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_536786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466097.1">
        <property type="nucleotide sequence ID" value="XM_025612110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDL0"/>
    <dbReference type="STRING" id="1450535.A0A317WDL0"/>
    <dbReference type="GeneID" id="37114253"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005796">
        <property type="term" value="C:Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF5">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="151"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="250" mass="27713" checksum="289377E1261C0398" modified="2018-10-10" version="1">MLSQRRIRLLTIAVLVMVLMAFYYSSEARSVQNQQFYRSTVAAMEARKQAKEAGTPANIPAPKEQTIQNPIKEEMKPVGNNDREEPAIPKANGAEEMEEIPIAGRTKMTIPKNRNDLEKENSEQAHAQEPERDDHAAAVAELNGILKRAPIIVFSKSYCPHSARAKSILLDKYSIVPAPFVVELDQHELGRPLQTLLGENTGRHTVPNVLVNGNSIGGGDDVTALDQRDELASTLKSLGGKWVQEVRRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDR0</accession>
    <name>A0A317WDR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Basic leucine zipper (bZIP) transcription factor atfB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_102610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family. ATF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466469.1">
        <property type="nucleotide sequence ID" value="XM_025605466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDR0"/>
    <dbReference type="STRING" id="1450535.A0A317WDR0"/>
    <dbReference type="GeneID" id="37107609"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021756">
        <property type="entry name" value="TF_Aft1_HRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11787">
        <property type="entry name" value="Aft1_HRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="11">
        <location>
            <begin position="408"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="433"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY84544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="520" mass="54401" checksum="B3362D76DE998E79" modified="2018-10-10" version="1">MSAAVASTVSTTLAHHTDTRNSSPMDVKKAGLDTEDSRATSSDLKDPKPDVDAQTSLAPPPRPAITSATDTPDYFNSVHNPFSLEPNPFEQSFGSGGSSGETPGKSILPPVAALTSPALPGATSASGGYGWSNSLRSGPLSPAMLPGPTGSSDYFDSIGRGFPTPNESSLRTGLTPGGGGSMFPAPSPNSQALLQQLQSGGATPSTIEFHRTALNAAKKNSLNGPTSNPTSDPDSAAQNSSMDIKPNQPAGADPFGHHDAADAANGLFMLAKGGQANPNQFSVPNQTSIQPQSIQANDQQLEAGADRRNSQNINGVTGRETSGDASDMQGEQTKPAGKGKAKKNSSKAGTAANNKRKPEDASKGINKKAKTSNGSGSVEPPSDVGDSEDEDDDLKRKSTTESKKMTDEEKRKNFLERNRVAALKCRQRKKQWLANLQAKVELFTSENDALTATVTQLREEIVNLKTLLLAHKDCPVSQAQGLGPIMMNTMSTGFDPHPYNLSGTMGMQPGAPIPAQGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEM9</accession>
    <name>A0A317WEM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_111320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466654.1">
        <property type="nucleotide sequence ID" value="XM_025605510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEM9"/>
    <dbReference type="GeneID" id="37107653"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="123" mass="12792" checksum="A74C04EEA01561B9" modified="2018-10-10" version="1">MPAALCSPSSTLQAIPRCPSQSPLSEICRLVAFPPRVANPSLKAISIAHKFCLSACLPICQATPLARVFQTALSLTPVPAPGPTSNSLSSFTVSPSTVGIASLDRASGIAPPIPPPRPYRRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFY6</accession>
    <name>A0A317WFY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha-1,2-mannosidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_118438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465885.1">
        <property type="nucleotide sequence ID" value="XM_025605557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFY6"/>
    <dbReference type="STRING" id="1450535.A0A317WFY6"/>
    <dbReference type="GeneID" id="37107700"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016307326" evidence="2">
        <location>
            <begin position="20"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="34"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="287"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="801" mass="88454" checksum="27BCDF5212511CAE" modified="2018-10-10" version="1">MVLWGSLAVFFALPYIVDCTNSSGAIDNYDVLQYINPLIGSANGGNVFAGATIPYGMAKAVADTDSINNQGGFAYDGSSITGFSSMHDSGTGGQPSLGVFPLFPYATCTNDEIDGCAYPKKDRKTSYVSDSVKSSPGYFGLNMSSGIQVDMTAAHHTSLFRFQFPTDKSSSPLILLDLSDLSDTRQDNGTISVDPTTGRMTGYARFLPSFGSGSYVPYFCADFHGSGDIRDNGIFVDARASADVKNLTISRSINGYPLPGGAFIRFNTSPDNIVHARVGLSFISNEQACENAEAEIHDFDFNKTYSAAVDMWTQKLAPIRVSRNGINSSTLTNFYSGIYRTMVNPQDYTGENPLWNSTEPYFDSFYCLWDSFRSQFPFLTIFDPAALTRMLRSLIDTQKHLGWLPDCRMSLCKGYTQGGSNADVILADAYVKGISDGIDWAAGYAAVQKDAEEEPYDWSNEGRGGLMSWKALNYIPVEDFDYIGFGTLTRSISRTLEYSYNDFTIAQMARGLNKTRDAEKYEGTSQYWQNLFRADQTSFLNGTDTGFEGFFQPKYLNGTWGYQDPLTCSNIDTSGRSCSLQNNAAETFESSIWEYQFFVPHDMATLVTLLGGPTQFVRRLDYLHDQGITYIGNEPAFLTVFQYHYAGRPGKSTARAHFYIPRYFNPTPTGLPGNDDSGAMGSFVAMTMMGLFPNPGQNVYLITAPFFESINITSPLTGKTATVSTVNFDPTYQNIYIQSATLNGQPYTKSYVGHEFFTQGQELVLVLGRNESTWGTKAEDLPPSLSTSQDATSNFRRDDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH38</accession>
    <name>A0A317WH38_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="15">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">TAH18</name>
        <name evidence="18" type="ORF">BO94DRAFT_518269</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="function">
        <text evidence="13">The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
        <text evidence="15">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="15"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH38"/>
    <dbReference type="STRING" id="1450535.A0A317WH38"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160246">
        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046395">
        <property type="term" value="P:carboxylic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000011">
        <property type="entry name" value="Electron transfer flavoprotein subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000013">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000030">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03178">
        <property type="entry name" value="NDOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028879">
        <property type="entry name" value="NDOR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 15" id="KW-0274">FAD</keyword>
    <keyword evidence="7 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 15" id="KW-0288">FMN</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 15" id="KW-0521">NADP</keyword>
    <keyword evidence="12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="16">
        <location>
            <begin position="12"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="210"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="65"/>
            <end position="68"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="395"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="433"/>
            <end position="436"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="543"/>
            <end position="544"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="549"/>
            <end position="553"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY85796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="929" mass="102612" checksum="E75CBAE36341ABD7" modified="2018-10-10" version="1">MNGTQPEQRRSALVLYGSETGNSQEVAEELGALAERLHFRTHVAELNQYKPEVLKLHTIVIFVVSTTGQGDFPVNARSFWRSLLLKRLPPTFLEGVNFASFGLGDSSYPKFNWAARKLHKRLLQLGANEIYRAGEADQQHPEGWTYPLPSGLGPIPDDVQLPPKWVLELQEQNTTEIKEDHMVSGTQEYQAAPDEFPKLTRLDHDLRPLPDTLTATLTENKRLTPSTHWQDVRHVLLTVPEHTSYVPGDMICITPKNFSSDVDALIQMMGWEEQADQLVSLVPNSHIPAEDLPSPPILGLESYPQLTLRALLADYLDIQAIPRRSFFAEIAHYTSDEMHKERLLEFTYTSPEYLDELWDYTTRPRRSILEVLHEFDTVKVPWQHAVSVFPILKGRQFSIASGGELKSAGGGTKFEVLIAIVKYQTVIKKIRQGVCTRYISVLRPGSTLKVQLQRGGLNSSVNQLVGPTVLIGPGTGLAPLRSMLWEKAAIIKAYQEENPGLELSIGPTLLVYGGRNREADFFFEDEWQQLGKLIKLNVLTAFSRDQKAKVYVQDVIRQNYALLFKLLHDMAGSVYICGSSGQMPKAVREALTEAFQHGAEVETDRFNEQGAEQYLLGMEKTGRCSVGSASLHASARLKCQFPSRPCPAPPPLTLLRDLPSTTINMASSLRILVPVKRVIDYAVKPRVNKANTGVEIAGVKHSLNPFDEISVEEAIRLRESGAKNQSPMKVDNILALSAGGAKCADTLRTAMAMGADRAFHVDVGDSADGGPEPLTIAKMLQGVVKSENINLVLLGKQAIDGDQGQTGQMLAGLLGWPQATQASKVEIKDAEGTVEVTHEVDGGVETLRAKLPLVVTTDLRLNSPRYATLPNIMKAKKKPLEKKTLADFGVEDKRRLKTLKVTEPPARQGGGKVENVDGLIGKLKELGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHM0</accession>
    <name>A0A317WHM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_468459</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyruvate + H(+) = acetaldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:45484"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466493.1">
        <property type="nucleotide sequence ID" value="XM_025608249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHM0"/>
    <dbReference type="STRING" id="1450535.A0A317WHM0"/>
    <dbReference type="GeneID" id="37110392"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000025">
        <property type="entry name" value="Pyruvate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="17">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="15">
        <location>
            <begin position="212"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="16">
        <location>
            <begin position="410"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY84568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="570" mass="62578" checksum="D450D26E4FD008E6" modified="2018-10-10" version="1">MATTDIATRELRKPISVPEYLFRRLYEVGVRSVHGVPGDYNLAALDYLPKCGLRWVGNCNELNAGYAADGYARVNGIGALITTFGVGELSALNAIAGSYSEFVPIVHIVGQPNTKSQKDGMLLHHTLGNGDFDVFAKMSAGISCTLGRLNETLEAATLIDNAIRECWTRSRPVYISLPTDMITKQIEGDRLDTPLDLSLPPNDPEKEDYVVDVVLKYLHAAKKPVILVDACAIRHRVLDEVHDLMETSGLPTFVAPMGKGAVDETRPNYGGVYAGTGSNAGVREQVESSDLILSIGAIKSDFNTSGFSYHIGQLNTIDFHSTFVRVRYSEYPEINMKGVLRKVIQKMGAVNAAPVPHLSNAVPEVEQSSGNQEITHDWLWPNVGQWLKENDIVITETGTANFGIWETRFPANVTAISQVLWGSIGYSVGACQGAALAAKELGNRRTVLFVGDGSLQLTVQELSTMIRNNLNPIIFVICNNGYTIERYIHGWDEGYNDIQPWDIKGLPTVFGAKDKYKGYKVTTRDELRQLFANEEFASAPFLQLVELHMPRDDAPAALKITAEAAATRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHR0</accession>
    <name>A0A317WHR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_597905</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466826.1">
        <property type="nucleotide sequence ID" value="XM_025616279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHR0"/>
    <dbReference type="STRING" id="1450535.A0A317WHR0"/>
    <dbReference type="GeneID" id="37118422"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF28">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016237541" evidence="5">
        <location>
            <begin position="18"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="57"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY85809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="495" mass="53795" checksum="53ABFBD25943A542" modified="2018-10-10" version="1">MQWLALPLVLIAPYLRSSLFSPSPCANLAILLPDKVFFPDSETYAASQRSYFALQEQQLAPACIVIPSSVEDVSVAVKTLADLPDSTFAIRSGGHSSVPGAANAHTGVTIDLHRLNDIHMNGDVVSIGSGALWTDVYDVLVPRGLAVVGGRTGNVGVGGLLTGGGLSAFSPHRGFACDNVVEMQVVLASGAIITSNTTHHPDLFAALKGGQNNFGVITRFDLATFPQADLWAGAIVYPASVDAAQLDAFRLFKNASAQAFDPHAQVELSFLFESREDSLAAYTSNNMFYTKPVVDAAALRVFSDIQPQMFSSMRVSNLSDFARELANSQPVGQFSIYATTTVRLSYTILPRIYEIWKNFTRNRMSSIPYLLSALTIQALPPIIPTSPNVLGFAPGTHPETDFVLLLVSNYWSDPAYSATMSSHTRALIEEIDAAAQSEGVSERFRYMNYADQWQGVLESYGRESVHELWRVSRKYDPQGVFQKKVPGGFKLPKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ02</accession>
    <name>A0A317WJ02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467027.1">
        <property type="nucleotide sequence ID" value="XM_025611822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ02"/>
    <dbReference type="STRING" id="1450535.A0A317WJ02"/>
    <dbReference type="GeneID" id="37113965"/>
    <dbReference type="OrthoDB" id="16547at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594:SF1">
        <property type="entry name" value="HD_PDEASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33594">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03035)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD/PDEase" evidence="1">
        <location>
            <begin position="42"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="235" mass="26253" checksum="05D4F65337D91992" modified="2018-10-10" version="1">MDSVDRILASAHAAPYGHLLPAKDDMFRSVALAVEAHMKHYDASHDFHHILRVLALSQRILSSEFENQTGPNIYDPTVVILSALLHDVNDKKYLPPAVDGQQISKVTLVLEQAGASTTLVNSVEEVVNHVSYSTEIKDPSKVQRVLQQHPELAIVQDSDRIDAIGAIGIGRTFTFTGAKLQGASMQNSREHIDEKLERLEGMMKTNTGRQMARDRTERLTVFKKWWDEETMLVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WK45</accession>
    <name>A0A317WK45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_467362</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466669.1">
        <property type="nucleotide sequence ID" value="XM_025608202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WK45"/>
    <dbReference type="STRING" id="1450535.A0A317WK45"/>
    <dbReference type="GeneID" id="37110345"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.40:FF:000003">
        <property type="entry name" value="Serine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="189"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="439"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="444"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="272"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="288"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="12">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY85652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="474" mass="53899" checksum="15A11F413EFF1481" modified="2018-10-10" version="1">MLDLADFISDRGGNPNKIKESQRRRFAPESVVDEVLALYEEARRARYDVMQINSQLNAVQKEIGKKKKNKEDASDLMEQKAGLENRKKDAEELALQKEKQRDGKIRTIGNLVHESVPVSNNEDDNAVVRMWTPENVKVEKRDCLSHHEVLTRLDGFDPERGVKVVGHRGYCLTGFGLFLNLALINYGLEFLWGKGYKPNQPPQFMLKEMMAKTAQLEQFDEELYKVTESEDKSTDKYLIATSEQPLSALHDGEWLQDKDLPIKYAGYSTCYRKEAGAHGKDAWGIFRVHQFEKIEQFVLTKPEDSWQAFEEMMATSEEFYQSLGLPYQVVAIVSGALNNAASKKYDLEAWFPFQGEYKELVSCSNCTDYQSRALEIRYGTKKATDVKKSYVHALNATLCATERTLCCVLENYQTDDGIIVPEPLRKYIPGAPEFIPYTKELAKDSTSNKSKSKQSSKTTSGPEETAKKLEGLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKK0</accession>
    <name>A0A317WKK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_110937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466645.1">
        <property type="nucleotide sequence ID" value="XM_025605508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKK0"/>
    <dbReference type="STRING" id="1450535.A0A317WKK0"/>
    <dbReference type="GeneID" id="37107651"/>
    <dbReference type="OrthoDB" id="5358398at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="204" mass="22919" checksum="B3353FF687E480FE" modified="2018-10-10" version="1">MNPLVSPHIPSPHLTPILPSSHRYHHNHNYTPHYHNLNTTHSPSPIHHKTSTLNTKMPPSLSWPKSLSLSLPTHTSSHFTTTLSTTTLTLTTLTIILCPLAYKNYKTYLSYGPGGAPYNLLGWFGVTFLLYPFGRNMTSTTIYEKKIASGETESFISEDVDTLLGELKRERAVVGPHYVPQRQVVEGEFAGEEVREVSCLFIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL49</accession>
    <name>A0A317WL49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_71672</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467434.1">
        <property type="nucleotide sequence ID" value="XM_025617621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL49"/>
    <dbReference type="STRING" id="1450535.A0A317WL49"/>
    <dbReference type="GeneID" id="37119764"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051000">
        <property type="entry name" value="Homeobox_DNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057939">
        <property type="entry name" value="TRF2_HOY1_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324:SF5">
        <property type="entry name" value="HEMATOPOIETICALLY-EXPRESSED HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24324">
        <property type="entry name" value="HOMEOBOX PROTEIN HHEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24818">
        <property type="entry name" value="PH_TRF2_HOY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="508"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY87226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="604" mass="65642" checksum="DE00FEE777F24EC9" modified="2018-10-10" version="1">MSSRDTPDPLTTSNSSITNAPTMTSSSSTTSSPSPAMSNSAAPSASARRPQRKSTLTQQQKNNKRQRATQDQLVTLEVEFNKNPTPTAATRERIAQEINMTERSVQIWFQNRRAKIKMLAKKSIETGEGCDSIPESMRQYLAMQFDPSKPGARDPFGRTGGYGTNGAYPHESAPSGKVVIHHFTCRSLTIGSWRRIGQNAMDLVVFYSPEKACMTYYINNDSAGYKIEYPFAYIKNITLESGDQTPQPNGAPPRPGGLVVELNRPPLFYMDSSNSGGFYQCGDFTEDQQASQIMVHHLGGHPKVLSVQLAKLVSLESFQNRLAYNNFAMNPPMSPPFIQRPASQPNQFAPTFLSVLPESHPHLNIHAMRGHKRQRSRSVPVAVDFSAMQAPLAHYNMPQTPAQFNHSDTGIFAPVPQSTHPLAVNLRIDTSAAYGFDPRTHPMSATTTASPSDFASPGLFSTGAGGDSTPVATNMGTPFNLPFVSPAVDSTVAPQAASYSNVSHADPMIANHSPPLSNISHTPQDMYSLGNEHQPTYTDDSMSMNGIYPKHNLSFAVPTSMGLESNTFDLPMQTMSGHTSPGVHGDFQSLTLENVDPNSLAPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLH2</accession>
    <name>A0A317WLH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_535444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467532.1">
        <property type="nucleotide sequence ID" value="XM_025611784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLH2"/>
    <dbReference type="GeneID" id="37113927"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="198" mass="22212" checksum="7091AFF0A3B14CCC" modified="2018-10-10" version="1">MSRSFSPWPRTSLGPRLCSPTPCTENWKDCILFLQTAEYSFLGFGTDCHEIAQSSIVHGMRPESRCVQVTASPETVNIPTILLPPRFPFMWGGLWVSQAGSLDYAINAGITMLMRLRTTEQLFTTSRGLWRPAGITPFDFNAAKSAAFRSTLGVLLHLSIRGRGNRIIRRSVPLKMSLVASLNRHVFFLQLQPLRTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMK3</accession>
    <name>A0A317WMK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_84651</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467093.1">
        <property type="nucleotide sequence ID" value="XM_025617704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMK3"/>
    <dbReference type="STRING" id="1450535.A0A317WMK3"/>
    <dbReference type="GeneID" id="37119847"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000283">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF38">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="15"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="496"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY86502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="536" mass="59438" checksum="23C6513ACA078377" modified="2018-10-10" version="1">MGTFGSQTSTYNRLVTIFVAVGSMTYGYCTSIISSTIGQPGWYTYFDLPADGEPGYASITTPVISTANGVFSAGGAVGALFIMWSCDFFGRKRNIQLGAFLAMFGGALQGGSNSLKMFQAGRFVCGLGIGILVTVCPMYLSEMSSAFRRGWLVGHHAIFLVFGYMLAGWVGYACYFAENKLGTFGWRFPLCLQCLPPLILLLGSPWLPRSPRWLISKGMHEEAKMVLERLRQSPDDPNNLVAKEEYYQTAEQIRLEGERLATYGNVWAAVLKKKSYRKRMAIGFLTQWGAEFGGPLIINNYAVLLYENLGMTGGMPLLLSAVWLTTAGLIYNPLGAWLHDRVNSRRKMYITGFIGIIITTSCLAAMTAQYAGTTNRVGNGFGILFIYLYLAFQGTFCDTTMYLYVSEIFPTEIRPIGMGFSLFGQFAATIILLQTAPTGFDNVGWKFYLVIICWSIFFIPVIYYFFPETARLTLEEIAKNFGEEVAVHLTDATDEEQARFQRDLEKRPDSLGHSDSSRDNEAGIPPSSSHEMPKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMP0</accession>
    <name>A0A317WMP0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="22">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BO94DRAFT_467008</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="function">
        <text evidence="21">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="21">Mitochondrion inner membrane</location>
            <topology evidence="21">Peripheral membrane protein</topology>
            <orientation evidence="21">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 22">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="22"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467133.1">
        <property type="nucleotide sequence ID" value="XM_025608191.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WMP0"/>
    <dbReference type="GeneID" id="37110334"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 22" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="16 21" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 21" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10 21" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17 22" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tr-type G" evidence="24">
        <location>
            <begin position="68"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="880"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="77"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="141"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PWY86542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2115" mass="236283" checksum="EBBE0BB3E155D9B8" modified="2018-10-10" version="1">MRGCLHLARWLSAAPKCPAASLLKPPTGLSNPARFFTTSAAAWASRSRGPARHPTSDLESRIADIPIERFRNFCIVAHVDHGKSTLSDRLLELTGTIQPGMNKQVLDKLDVERERGITVKAQTCTMIYNHNGEDYLLHLVDTPGHVDFRAEVSRSYASCGGALLLVDASQGVQAQTVANFYLAFSQGLELIPVINKVDLPSADPDRALEQMEHTFELDTESAVLVSAKTGLNVQQLLPTVVEKIPAPVGDYTKPLRMLLVDSWYDSYKGVICLVRIFDGEVRAGDQLASFATGIKYFVGEVGIMYPNETPQSVLRAGQVGYIFFNPGMKRSKEAKIGDTYTKVGFEKAVEPLPGFEEPKAMVFVAAYPVDADHFEHLEDSINQLCLNDRSITVQKESSHALGAGFRLGFLGTLHCSVFEDRLRQEHGASIIITPPSVPIKVIWKDGKEEIISNPAKFPEDEELRSKVAEIHEPYVVATLTLPDEYLGKVIELCESNRGVQKSLEYFTSTQVILKYELPLAQLVDDFFGKLKGSTKGYATLDYEESAWQQSNIVKLQLLVNKAPVDAVARLVHYSQIERLGRQWVTKFKEHVDRQLFEIIIQAAVGRKVVARETIKPYRKDVLAKLHASDVSRRRKLLEKQKEGRKRLRAVGNVSLSPCHDHHLTTAMQPPEGVQVDLGKAQVIDRVPKVISELKFGVLSNDDIVSQGVVEVSDRKFFDLDHDRAVVANGPLDARMGISNKTSSCQTCGGTLQICNGHFGHVRLVLPAFHVGYFKRVITILQEVCKECSRILLPEADRRAYLREMRRPGLDNLRRGQIAKRINERCRKTRNCEGCGAVNGVVKKAGTSALKITHDKFRAFNASTSVKKVPPPSKIVFDRSFDEARTSNAEVEKHYKKAQDDMNALRVLNLFKKISDTDCELLGLNPKEARPEMFLWQFIPAPPVCIRPSVGQDAASTEDDLTAKLGDIVQSNINLKNALLKGAPVQTIMECWDYMQLQIAVYINSDVPGLNKADLGKPIRGFVQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRVDEVAVPELVAKNMTYPEVVTRYNKEKLQQRVRNGTKKWPGANYIMKKGQTFKLFLKYGNLNMIADQLQEGDVIERHIEDGDIVLFNRQPSLHKLSILSHFAKVRPHRTFRLNECVCNPYNADFDGDEMNLHVPQTEEARAEAMELMGVKNNLATPKNGEPIISAIQDFISAAYVLSSKDNFFDRRSFTQICLYMLGPQTRFDLPPPAVLKPQMLWTGKQVFNILMRPNTSDPVLVNLDAACREFKAPKDGRPRDLDPKDAWLVIRNSEVMCGVMDKSTIGSGKKDNVFYIMLRDYGPAAAAEGMNRLSRLSARWFTNMGFSIGITDVYPSESLLRSKHNLVETAYAQCDEVIAKYKAGTLEKYPGCDELQTMENQLSGILSKVRQQAGDECIAQLSKYNSPLIMATSGSKGSSINVSQMVALVGQQIIGGQRVQDGFQDRTLPHFPKNARQPPSKGFVRNSFFSGLEPTEFIFHAMSGREGLVDTAVKTAETGYMSRRLMKSLEDLSTRYDDTVRNSSAAIVQFQYGDDKLDPLDMEGKAKPVHFDRTFIHSESTTYKNDERSLLPGEIMDICEEMLSKERAKLVRKDLMGNELGYMDRSDHGIDQFESARDFLESIQQYVATKADKLISRGGDINVNDERSRKGLNHTGKLTERTLRAFISACLMKYKKAQVEAGHAVGAVGAQSIGEPGTQMTLKTFHFAGVAGMSITQGVPRIKEIINASKEISTPVVACELVTKDNIIAARIVKGRIEKTYLRDIIHYVRETWTGKEAYITVKINWKTIQDLALELKIENILAAIKGHKRFKADDLKFRCSRSHIHVYMDVDPSTKANLSKTEIASTSADPFLRLKHLKRMLPDIQVLGHPQAFRAIIRTDETSTTNTLLVEGYGLRECMTTLGVDGLRTTTNNVMEARDVLGIEAARTTIVQEISEVMKDMDIDPRHMQLLADVMTYKGEVLGITRFGLAKMRDSVLQLASFEKTADHLFDAGGAGRSDLIEGVSECIIMGKTVSLGTGAMEVVRKMNFFEGQIGARKTTFEDTWTEVYEAPLERAKARRKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN69</accession>
    <name>A0A317WN69_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_57554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467672.1">
        <property type="nucleotide sequence ID" value="XM_025615079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN69"/>
    <dbReference type="GeneID" id="37117222"/>
    <dbReference type="OrthoDB" id="5355126at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="108" mass="11694" checksum="FEEC230AC84C83B0" modified="2018-10-10" version="1">MSKNPTALYLGIAAKEQAKQDAHLARLKAPTGNQAEKAGEKAAFETRLNVDEAIDTSTHEAKNNLNRLEKITRDTTAELRSGAEKIEGKVEEKAAEAKGSLSGWFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNI2</accession>
    <name>A0A317WNI2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="10">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_491968</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467779.1">
        <property type="nucleotide sequence ID" value="XM_025609171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNI2"/>
    <dbReference type="STRING" id="1450535.A0A317WNI2"/>
    <dbReference type="GeneID" id="37111314"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY87996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="602" mass="66818" checksum="668EE9E1A2307229" modified="2018-10-10" version="1">MSTIELGDSIPSLTPHAVSVSLPTWRDNVGYEEGDKRVLDKLPTGYPRFFIHKLIVAFADDIVAKYGTPDQTAMLFPFSKISQRCLDFIKAKAESGFAGDIKIINLFLDKSKEVSDMIAKVSPSVSAVIFHKDLFPIAKQYWQHSGDGISSRQAEFCHALFLDGKLINPAPPQPTVNQKRGPKRYQRGSGFQTPPRESKATSENVGVSQLSSKTDAAERESTQFLEERFGRNLDISFVDNAKVAIRRRVAGSLVDEVDLAVEPRPNTASNTRGVTGLSDNDVYLYPCGMNSIFNTHRMMLKCKGQLKSISFGFPYVDTLKILEKFGPGCLFYGNGSSEDLDDLEARLKAGERYLALFCEFPGNPMLACPDLKRIKKLADTYDFGVVVDETIGNSINVQVLPHADVVVSSLTKIFSGDCNVMGGSAILNPEGKYYQALKNAFDADYEDTCWVEDIMFMERNSRDFVNRIREINHNAEAICDVLHAHPLVKEVYYPKYGPSNQFYEDCRTPTGGYGGLLSFTFHQKKHAIAFYDRIETAKGPSLGTNFTLVSPYVILAHYWELDWAAGFGVPADLLRVSVGIENSEDLKARFAVALQAAEAVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQJ8</accession>
    <name>A0A317WQJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_535610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467041.1">
        <property type="nucleotide sequence ID" value="XM_025611828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQJ8"/>
    <dbReference type="STRING" id="1450535.A0A317WQJ8"/>
    <dbReference type="GeneID" id="37113971"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016442000" description="GOLD domain-containing protein" evidence="10">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY86450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="210" mass="23729" checksum="6B31739B8256D098" modified="2018-10-10" version="1">MRFAALVIGLLATFVSSVAATALTYRLEANEKACFYSYVDQRNVKVAFYFAVQSGGSFDIDYSVVGPGEKVVLDGTKERQGDFVFTAQSIGEYRFCFNNDMSTFAEKIVDFEIAVENEERAQLPSRQGASPEQASALEESIFKLSAQLSTITRNQKYFRTRENRNFSTVRSTERRIFNFSVIEGLMMVSMAALQVFIVRFFFQGARKGYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQK3</accession>
    <name>A0A317WQK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_464580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468065.1">
        <property type="nucleotide sequence ID" value="XM_025608073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQK3"/>
    <dbReference type="STRING" id="1450535.A0A317WQK3"/>
    <dbReference type="GeneID" id="37110216"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="182"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="342" mass="38141" checksum="E2A205EA8FBF5C59" modified="2018-10-10" version="1">MSRQPKLRPKSHIPGFPDAIYNLAAVSSLSQLESRAGLGEEKHDQRVFRVKRKHVLKACDRCRVKKTKCDGKQPCNRCSAYNHPCLFRERKATQTKVYSRGFVEMLESHHSLVVKALQRLYKLCLDKEGFPGEPLVEVSDGHPLTHAILDRLGLIKQAEENPDEPEEDSEDLRYLRFLSTSTDCSATTDPSPEPATPPDPSPSNCSPITPSSKGNEPWKWELQPVQPLHSGHYGYPHPGYHPMAMPRPSLEPTGLPVEPKSPDIVPPMADHGHSLYYYMGASCDEGPTKSRLEAEVTARPESQQPATASGFPVVMMSDYNLHVQEHQSVYPPLPSGWAYTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WS88</accession>
    <name>A0A317WS88_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_594729</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467953.1">
        <property type="nucleotide sequence ID" value="XM_025616209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WS88"/>
    <dbReference type="STRING" id="1450535.A0A317WS88"/>
    <dbReference type="GeneID" id="37118352"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF9">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="502" mass="58294" checksum="BF66C896A08E7E06" modified="2018-10-10" version="1" fragment="single">PVFGYRFFLEPTFLLKSRFILGARGIIHNAYTTMKGHPFVLRRWDVDFLVLPMKYLEEVRLIAPSKLSSKGAQTGNLAPEYTSMQFLYHSNLHLDVLKKKLTPELYTYVDKAKEELVYGWERDLPHTDADYFCFNSIEWTPVPIEHLLRMLVARMTAKVFMGAPTCRDPDWLRISIDFSVDLFTTAFTIKMFPPWLYGVVARLVPARYRTFQQLKTGRRIVGELTQRHHLVQEKRRRGEMVEEEEEEEDTLLNWMLDHGTPSEVEVHEMGARQCVLTLASIHTTASNVSNMLYDLCTYPEWFSELRAEVLTIAEQLGGPPGQEHPPVSAKEWCSRLDKLDSFFVESQRHSPVLLLNPQRLAYQDIILKDGTLIPKGSRLAFANHEHSMDPTVYPNPQSFDPMRSYRKRMSHPDQRDRHKAGMTHPDNLAFGYGNQACAGRQFAVAEIKLIMARLLYDFEFEFPADQNARGRPRTLHINENCFTDQEARLLMRRRVRGRGREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WST9</accession>
    <name>A0A317WST9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_556220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468193.1">
        <property type="nucleotide sequence ID" value="XM_025613848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WST9"/>
    <dbReference type="GeneID" id="37115991"/>
    <dbReference type="OrthoDB" id="3549294at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="611" mass="68443" checksum="901E1E8D680F6BE3" modified="2018-10-10" version="1">MTPHAQLLSSFEAAPNADENEVQKRDTNDLHPPQLSGIVADSDALQPTKQQLEDALAKSRSYWYKHGIKPELANPHHMLMKVLSMHAGPHTTHSHHVGASLSPLLCLQASVSWHVDESTDCDRIERDKTNIVLLYIGTKASVPYALNGNGFRHWVGTEDETAGRGGMKYTESKAAVYRQTTQYTPTHMIDIGEADDDTISWWSSILAPGDGWKAIMKECDDGEFLAPWSVICRSQQSFAIQCKRKTATGDFPPIPMSSSRAFEALSRFALMYNLGSQFPVALGTAITVPTHNCHGSTIQLPPPTLTGAQFAIQTLFMSSLCGMFWEPGVPCNLVSAWLHPILNEVPEGTKFEDLPGLYYDILAIICGIRRPTISALWLGAVAGGLAPIILRRTRRGRPPLDPVAFPWTGCLQSFMDIAGMGPYIIDQYKKQVRRADVWRLLHLPTTEEDDLSYNYPPRTPWEPCGMMETRNCALRVASHLDCPRHHLRYQYWIWEPENGPAIQDKGFSMATVMPTTLDVDSLRVQDLQRFPHKPLDQDASEEASLDIFRWFITNGEGFPPGMIYKDEWLEGLDDEDTDEDQEDDGMKSNSSRANHPNNLEKWLATLQDPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT99</accession>
    <name>A0A317WT99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nudix/MutT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_40778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468470.1">
        <property type="nucleotide sequence ID" value="XM_025607387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT99"/>
    <dbReference type="STRING" id="1450535.A0A317WT99"/>
    <dbReference type="GeneID" id="37109530"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034431">
        <property type="term" value="F:bis(5'-adenosyl)-hexaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008486">
        <property type="term" value="F:diphosphoinositol-polyphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901911">
        <property type="term" value="P:adenosine 5'-(hexahydrogen pentaphosphate) catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901909">
        <property type="term" value="P:diadenosine hexaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901907">
        <property type="term" value="P:diadenosine pentaphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071543">
        <property type="term" value="P:diphosphoinositol polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000046">
        <property type="entry name" value="Nudix/MutT family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF0">
        <property type="entry name" value="DIPHOSPHOINOSITOL-POLYPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY89559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="162" mass="18217" checksum="AFA581F89E179551" modified="2018-10-10" version="1">MFKMADHPRSMESRVGRKNQRYGPKGERLVAGVVPLSTDKTKVLMIQSAGRGGWVLPKGGWETDEVSAQQAACREAWEEGGIICTVQKDLGLIPDLRPSALLTSTAPKASYQFFEVTVDREEDQWPEMHKRKRQWVSYATAAEALASRPELLEALKRSSMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTI5</accession>
    <name>A0A317WTI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="4">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_464451</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467954.1">
        <property type="nucleotide sequence ID" value="XM_025608063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTI5"/>
    <dbReference type="STRING" id="1450535.A0A317WTI5"/>
    <dbReference type="GeneID" id="37110206"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF42">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02280)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="14">
        <location>
            <begin position="98"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="429"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY88592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="486" mass="51244" checksum="EB49060236C56E76" modified="2018-10-10" version="1">MSYRNLSSIDVGDRTAIPDYELHNVPVAPPYSATDPAPAVAAAPAAEKSNVAKSAGGAWYDPRSWSLLTKLIIAGGVVVVIVALVVGIYEGTKSSSYPDYSALSYRLADTYSGSSFFDEFEYYTATDPTDGFVDYVDSSTASEMNLTYASSSRAVLRVDTSTSNQTSGRKSVRITSKKTYNDGLFIFDITHTPYGCATWPALWLTDPDNWPEHGEIDVLESNNKGTHGNAMTLHTTKDCTMNVKRKETGTASYTNCLNTANDNAGCSVSGGKATYGEKFNSNGGGVYAMELRNAGIRVWMFSRDDIPTDISNTSDTPDPSTWGEALADFPNTNCDIASHFKNQSIIVNIDVCGDLAGATTYYTDLYDCPSTCTQWAAENGANFTNAYWEFKSFKVYQTSSSSSSSSAAASSATAAAAAAYGTSTTTAGAATATATSASTGQGQSGSQSGSGQQGEGNQGGGQSGGQSTNQEEESTNQAQRGQGGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTQ4</accession>
    <name>A0A317WTQ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Folylpolyglutamate synthase</fullName>
            <ecNumber evidence="17">6.3.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Folylpoly-gamma-glutamate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Tetrahydrofolylpolyglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO94DRAFT_556020</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>a monovalent cation</name>
            <dbReference type="ChEBI" id="CHEBI:60242"/>
        </cofactor>
        <text evidence="17">A monovalent cation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.17" evidence="17"/>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467929.1">
        <property type="nucleotide sequence ID" value="XM_025613835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTQ4"/>
    <dbReference type="STRING" id="1450535.A0A317WTQ4"/>
    <dbReference type="GeneID" id="37115978"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023600">
        <property type="entry name" value="Folylpolyglutamate_synth_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038895">
        <property type="entry name" value="FPGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 17" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="19">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR038895-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PWY88567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="491" mass="54629" checksum="6CE37BFF02B51F21" modified="2018-10-10" version="1">MAYGYMFSFHPWRSAIKETEFPSHADAIEKLNSTQAGFKVLEERRRTGYKAECSGLEQMPEWLRRLGYNVSDLNRLNIVHVAGTKGKGTTCAFVSSILLEYQRTVGVPRKIGLYTSPHLVSVRERICINSQPISEELFARYFFAVWDALESSAIKEELDPAQKPGYFRFLTLMSFHVFLSEGVDAAIIEVGVGGETDVTNVIPQPVVTGITTLDIDHVKSGSSAFTVSQVPDAREILEQRAQEKNVNLGTVEICSALRHINIKPTEDFQKANASLAIVLACTLLNIFGIEANTKGTNLPTQFVQGLEKVVWRGRCETVDTGRQHWHLDGAHTERSLEVACSWFGRGSHAKDSPHVLLFNQQSLRDAAELLRTVHRVIYESCKMTFQYALFCTNTTYKDDNHKADLVNRNVNPQALKSLSLQGELVDVWHGLDSSTEVAKVLSIEEAIEYVRNIKGGTPETEILVTGSFLLVGGALMVLEDKHAVPQMATAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WX65</accession>
    <name>A0A317WX65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_595126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468192.1">
        <property type="nucleotide sequence ID" value="XM_025616215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WX65"/>
    <dbReference type="STRING" id="1450535.A0A317WX65"/>
    <dbReference type="GeneID" id="37118358"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF64">
        <property type="entry name" value="IQ MOTIF AND ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="306" mass="34751" checksum="F13885F353E9C236" modified="2018-10-10" version="1">MPPPHLPYEMKTAIAKFLTRKQDLNALAQTSRDFYHAVNPVLYEKAVTTHRLSIFRWAAMNGQVSTIQMLLEHGGEVPRPGSYELPEFYDTDHVEYNPRLDELRYDYRWARTITYAAYNGHVGVVELYLDKRGASPNHRDRDGYTLLHHAVLNNHDSLVRMLVERGASINHCNGEDQTPLVVKAAELGNLAMVECLLSPTKKRYPRNYLKYICRAVRSAIFSKSAVVVEFPLSQGAPLDIPGKELSGDPFAAAFLSNNKRLLSLVLDHGAKVSDRQRLGVYRRAAEADYVDMLKLVVEKRPGWRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYZ0</accession>
    <name>A0A317WYZ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Protein SUPPRESSOR OF VAR 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_462437</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469301.1">
        <property type="nucleotide sequence ID" value="XM_025607975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYZ0"/>
    <dbReference type="STRING" id="1450535.A0A317WYZ0"/>
    <dbReference type="GeneID" id="37110118"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.40:FF:000002">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001109">
        <property type="entry name" value="ATP-dependent RNA helicase suv3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1080:FF:000005">
        <property type="entry name" value="Mitochondrial ATP-dependent RNA helicase Suv3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="238"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="595"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="595"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY91573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="634" mass="70703" checksum="18AEDA9D4AE4E2C4" modified="2018-10-10" version="1">MLNACKMDENGKSAGSLRHVKNTLLRSYLQNGLRGLASELEFHMYAEDVTSKYSAPNLEAQKKMADLRRPAEWYPQARAVQRTIHLHVGPTNSGKTYHALKRLETSGRGFYAGPLRLLAQEVFNRFQANGTSCSLITGDEVKLAEDGKPSKIVSNTVEMVSLGDTYEVGVIDEIQMIADPHRGWAWTRAVLGARATELHLCGELRAVPLIKELAALTGDKLEIHRYERLNPLKVQNRSLKGDLRNLQKGDCLVSFSRVGIHALKADIEKTTGKRAAIVYGSLPAEIRTQQARLFNDPDNDYDFLVASDAIGMGLNLSCKRVIFETLIKRVPGGLQRLTVPEIKQIGGRAGRYRSAMQHESDGSEDENVGWVTSLEDIDLLYIREAMETEPPPLVSAGILPPDSVFQKISAYFPQNVPLEYLVKRLSVVSQVHPLFFLCDPRNQLENAEVIDTVDGLRMADQLTFMAAPMHTRLIAGRDAAVAFIQCVADHSDGRLLDIEALNLEILEEPVSGNKEYLNELETLHKSVILYLWLSYRCGGVFTDRALASHVKQLVEERMVRALTEFSANKKLRKDASLRRQIALAKQMREEKELLADADVDSYGTEDETAAVNLSTEENQLEEPVEEAAPQARTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZV4</accession>
    <name>A0A317WZV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469621.1">
        <property type="nucleotide sequence ID" value="XM_025611308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZV4"/>
    <dbReference type="GeneID" id="37113451"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="51" mass="5767" checksum="B50CBB0BEE2ACADE" modified="2018-10-10" version="1">MQENVAIAVIIIVLFIILAIAGWWIHRMRNQVAFSREKRAVDEESGGEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X240</accession>
    <name>A0A317X240_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_573513</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469400.1">
        <property type="nucleotide sequence ID" value="XM_025614973.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X240"/>
    <dbReference type="GeneID" id="37117116"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF16">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="418"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="916"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1226"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1270"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="308"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1270"/>
            <end position="1289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY91672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1480" mass="166141" checksum="F4714B28429648BB" modified="2018-10-10" version="1">MAKLDHDVARPPKKSPAGVTSAPKPKPKPAAAAAPKPKAPTPAPAPSKTPTPPKNTKPTLEPKKSNGIAKAKSSFNSNSTSNITGSTTSTLLEPERNLWEEAWMSVDVGDDNRNRLSQKWHNKTLNRMGKLPKDYVESVMELTKSKLSVYQERWPSKSREIAYDRSVSILKSAMAVKALGDVVVKFDPTGYASSAWAVVSFGLTLVQNTQERMQRTLEASQYLAVLLARYSRIEAHYHRVHQNNAEDLGNAIVKVYIGVLRYSAKVKEAATSKRLDRVVQSFKSLTDEPLKALKTAIENDDQMVDKWYRQLMAEQQQLMLESQEEEIQRVKEVQDMLSKASHNASLIIQGVAKIDTALSSEILTQLLEWLFPNGKDAPSESKHRRLRSAIVTKPGPHTAGKWLLERHDYRDWVDHPQSLLWLYGESGCGKSSLCSTIIEQLDTMIKKDRDRVLLRWYFRFDKPDTMSIDLLLRFFLRQLGSSLGGFPEEISTSLEDDRRFARYPDTKVLIEYLHTVLAAIEFHKDVFIVLDGLDEFPTQSKDQNRRDLLDLIRRLGVSGLSNLHILLVSKNEEDIRECLRGRLKDILVQIDVTEGLDIDIRNYINTIMNQGEGIGDLDKPLKSSIRARLTQGAGSNFLWATSLVQELRDCRKDPNKIEEKLNTVPTSMVAIYEKHLSSVKEADERYVKLIFVWLLRQLRPLTQDEIAAAVGLHDVDAVYDICTGRWVTQSTQTVTINRQHQTSEKVLQFTHFSAKEYLESQLRLSSQSSISRFVCSEEEAHVTILQRCLDILIQSRETDDTTGKTSLDSKLTNYAAEYWFEHYRQLEKTQGLAEERSLVQQRVIQLFQSPESFGAWLDCFDPDRQSTPVEDPGKKKSIQRWRRASPVYYAIKLRLKTIAEDLLKGEPKDLNLRGEKGETVLQLAVYQAYRTVTKALLKHNVDVNAEKGQHGTALYVAAARGYASIAEVLINAKARVTGTEDGTLGNPLHVSAYRGHDSVVSLLLAGRQSTSKQSRGVPVDHLAGFFGTALVAASSVGNESTVQMLLERGADPNFVGGRLGTALQAAWNAQPRPKGVIAVLKASGAKYQQNEDHPWTTAYRRIEKGDKDAIRTYQKLFLPQQTITKEVSERQKLLVAALDRWKGLSRLRTLEVCQTSLTTACHCVAPFDEQLEAIKRLVSRLTVDDEDWRSEDLLYKALFWAGISHILENLGPLVLKCMDGVMNESQSLKKPSSKETAPFPHALTTGLPRDITKGLSSAALSDMVAIDLEQQRKQTNDKNTQERASETKRAGLTPGYLAASDLMTLVKNLIRFGNKCTQYHRLASRDEIEIPHWTKVAIEDLTFELFAAVIRLATIKQWNHESTVFQQTIRSLTTVRIPRINDLDTACCRELALAGTSTHRQSNLDREDQYSEAANKLQDAILGQIANVQAGISAQLDGFQTRLIGDIQSRLSELIGQEVSRAVKQIQPAEEVDAPGAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2G4</accession>
    <name>A0A317X2G4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_380240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469530.1">
        <property type="nucleotide sequence ID" value="XM_025607256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2G4"/>
    <dbReference type="GeneID" id="37109399"/>
    <dbReference type="OrthoDB" id="4506575at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21050" checksum="0FDEEE8C4C4F6E17" modified="2018-10-10" version="1">MFANMDRQISYTGPLPSTTSKLHHLPQIDPLFSLPSVPYTSTLKPHTTPMNHPLPPKPPVSKNFISGSFAPPHASATAPRNAKGKGNSNTGENMGKLHTKRAVCRDTAIRSPVNTLGISKAASQIKVHGRDDLELIDRMLDDLKSLDELDDLPHPDTLFSFSQKDDNLHNKSPGEPLGTAQLYTWPSDIQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X383</accession>
    <name>A0A317X383_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbon catabolite repressor D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_544654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. May be involved in signaling by recognizing appropriately phosphorylated substrates via its arrestin domains and then recruit a HECT-type ubiquitin ligase such as hulA, leading to ubiquitination of the substrate, providing a link between ubiquitination and phosphorylation in protein regulation and stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469695.1">
        <property type="nucleotide sequence ID" value="XM_025613192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X383"/>
    <dbReference type="STRING" id="1450535.A0A317X383"/>
    <dbReference type="GeneID" id="37115335"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000018">
        <property type="entry name" value="HECT-type ubiquitin ligase-interacting protein creD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="7">
        <location>
            <begin position="198"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY91967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="613" mass="68200" checksum="2242252529214720" modified="2018-10-10" version="1">MALSFFGGGGSSSHAKYFDIRPASFLNMTTNPVLSHNSLDEDYIVFRGGEEEAASAHLSGKLILCLSEPLSIKHIRLHLTGISRVCWHLPSSTAGGGRKSWRERVFYEKTWRFRDAGKSKTEVLPAGNYEYPINLVLEGSMPESVEGLTDTYVTYRFKAEIGRKYAKDIIVRRPLRIIRTLEPSALELAHAMSVENVWPNKIEYSISTPTKAVIFGTSIRVDFKLIPLLKGLRIGQIVSQLIESHDLTLNPEDPDSIRNTYKSTRTILNDEHELDEDNGLEIIDEMAEGFQFSRHLELPKTLARCLQDTDTRGIKIRHKLKFRVQLLNPDGHVSELRATLPVSIFISPNLAIDENNNLVDQTPQTAQRAIDDLAQQAPPLYGEHQFDQLYSELDPSGYRTPGPGSGPGTPFGTLSRNLSAENLASMNALTNTDISASALHTRLAILRANGHNHHSPTDQDHTENESRRLGIPPDYFGPSSAPNSHSPTSPELSRRPSDEVDHDYIHSGMATPYHPQYAEVETLSRVPSYSTAVRSTVRPCDSELPDYQAVIAEDVIISAPQSPQQAYIRTAGRGSSYFSAIDALHSRSGLLHSTSSHDDDDRRLRLVQARARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5S2</accession>
    <name>A0A317X5S2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_313232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470680.1">
        <property type="nucleotide sequence ID" value="XM_025606841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5S2"/>
    <dbReference type="STRING" id="1450535.A0A317X5S2"/>
    <dbReference type="GeneID" id="37108984"/>
    <dbReference type="OrthoDB" id="4510310at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016311095" evidence="2">
        <location>
            <begin position="25"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="902" mass="93575" checksum="B4326228796E652F" modified="2018-10-10" version="1">MSLFTTKTLLAGLWAISTISPSLGLPQSSYPSSSVIASYSSRASSESPHPWSSEPDSASTITTSSVPLYFPSWTTHPFSSTQDTLTEPATSHSLIHSSGTTKTAHSSAPVDSLHSVFGSSASIFTPSIAHTTLPSSSAGLFAQHYTTSPTPSHSHLSTETSTSPSTSLFTSSLSDSSTEARTSSSKSSIHIISNYSRSSGHVPSESSTPVSSVTTSKHTQTYTSTSPLSSSKAPTSSSTSTQLESSTSSSTHVQSQSSTIPTPLVSKSATSSTTKTHTYHTRSESSSSSTTSPSTSTQSSSSSDTTTTAQSSRTDNITSAPTTTGTPTTTSASTTTSSSLDVYSLIKHLYKLVKESYPVVKKWMKDKDSVKASDVANIVKRVIPVADDILDSLNAPSVLESSSGGGSDGCSSGGGLLGDVVGIVSCIASTADDMVTVLDKVPSSGDDDSSYISSVSSFFEAFQTEGSSLSAVGITATGSAATNTGSTTTTTLDTASKSSKADSSATSTSQSSSAVSTSSSKSHSSSTSTLSTSPSSTSTSESSSIPRTSTDLASSKPVSSTAAIKSETLSSSSTESTSSSTSRSLSASSSHISNLSTSMTNTTYTRTESNSSTATETTSTIIVHTLSGATSTTHHPSTITASPSRNQTATTLITSYTTASASKPLCYNYADPDNNAGDYCICTQDGHTTTMPVITTSNSVCDYTTLPPPITTSTSTKPTTKKPTTHAPFTTSYIDGDVIVCASSTLSYFQYSTTTYTYTKCAGSTTAIKTGTHTTTTTAATASPTAQLVISYLTNFYSYWAFFTPDIGSDFNVCDGSIGEIEASGSIKVADPPYPDGTKKLDFKVHGMKDCVYEGTEKKPGTFTCPDLGKTVQCVEYPVNKVLDCYETVTVDMYNPKVWCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X601</accession>
    <name>A0A317X601_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_511339</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470382.1">
        <property type="nucleotide sequence ID" value="XM_025609762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X601"/>
    <dbReference type="STRING" id="1450535.A0A317X601"/>
    <dbReference type="GeneID" id="37111905"/>
    <dbReference type="OrthoDB" id="4835445at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="694" mass="77611" checksum="3326D0E3F4D8F3CE" modified="2018-10-10" version="1">MRRVKKSRNGCARCKSKRVKCGEERPHCSRCTRLGVNCPGYVQSLRWVTKYPPLVHGEPNQDTAEAEDIPDESRSTPYQHSDLKNLATSPLNPDFVDPLVVQTLTVDGDSLNLTASDDPANPRNLDEPNGICDSLWDLQQNGSLPELADLQSPVPTSVSSSGQPNPALNYESSGSHVEDPFGLFSLAAPALQDEPHIFSGFSPSAIVRQYPPPGSRPPQRDFAAIPQPLNNPSWTLIEYYFKEVAALFSSYDSQMNPFRSTVSRLWGSSLAMCRTMQSMAAATLVQDFPQFGPLGRKMRDEAVDIITKESTLDDKSLLALLMLGQTASWHDPKDLGISFFNLLRNHLDTKQAGPPIPGRSNNHQFFEEALVYWEMLLSFVADDSAVLSGSAAVAADESLVLQRVPHPWTGIARDTQYTVQEVGRLIRRERRRIRSRSFTSNADIARAQQAMEKARELEERLLGLAHPAEAEIVSPGDDETPVWHLLTMAEVYRCTGLMQLYRVFPDLLRRRLPPQRPPNPHDPATTIRDPFLSPPMGGTPWFCEASYAPSNSEPTETADPTTAHPESYYDSWLTEFTLTTLSRLKTIPLESRTRCLQPFLLVASSSELRLPRLPPLDTNLDSNGPSISSHAVDVSRTRRFILGRLTSYLHVLPPKPIGVCLQLVREVWRRMDAGEPEIYWMDIMIEKGWETTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X624</accession>
    <name>A0A317X624_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_511383</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470402.1">
        <property type="nucleotide sequence ID" value="XM_025609766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X624"/>
    <dbReference type="STRING" id="1450535.A0A317X624"/>
    <dbReference type="GeneID" id="37111909"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY93641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="465" mass="52473" checksum="E26D218840A5EA08" modified="2018-10-10" version="1">MILYNIFLHPLRCFPGPVLFQATGLMKAGHMVSGNLQFKVKLFHDQYGPVVRIAPNELSFIEPQAWKDNYGHRTGGELPKHYSLYRLDQSAPCNIISADQEQHSILRRLLSHGFSERSMQAQMPIIGGYVDLLMQRLRGNAADGTTVVDLNSWFNWVTFDIIGNLSFGSDFKNLGGADWHPWVRMSAKHNKLSAILASLRGIGLGVLVRWFVYSGLLPTQTYLNYIEQQVRRRIDAGDQRPDFIEGLVQRKNDLSAHEIAANAEALIGAGSESTATLLSGVVFSLLTHPKCLQKVIEEVRSQFRNEQEITLTSVQRLDYMLACLNETFRYYPPVTNGMPRCTPKGGAVICGRHVPEDTVVAIWQWAICHDPGLWTDPDGFHPERFLGHPKFADDRLDALQPFSVGARNCIGRNLTYAEIRLILARLVYNFDLELCETSKDWIGVQKAYLVWDPPSLNVRLVPAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6E2</accession>
    <name>A0A317X6E2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_321576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470890.1">
        <property type="nucleotide sequence ID" value="XM_025606902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6E2"/>
    <dbReference type="GeneID" id="37109045"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016407242" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7951" checksum="6A1542E168EDA513" modified="2018-10-10" version="1">MIRRWAERLLLLVVEAVLFPQPIDSSERIIRATATLGAHYLVECSLPGYSLPDLSPPLIFYLLMGQPRADG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6I6</accession>
    <name>A0A317X6I6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_323479</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470940.1">
        <property type="nucleotide sequence ID" value="XM_025606915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6I6"/>
    <dbReference type="STRING" id="1450535.A0A317X6I6"/>
    <dbReference type="GeneID" id="37109058"/>
    <dbReference type="OrthoDB" id="2020758at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="143"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="615"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="621"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY94179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="663" mass="73722" checksum="4C24288FE1CD71A0" modified="2018-10-10" version="1">MNARREGIDFLTQNPFSVQYSNYEKVLQHLQDNPSLVAYIFITVITVYLGLRYLGLVSLSLARVIWNIVVYLAPSRLVAALDSKAPKSDTADENPLSMTFEAKSEAMRRVFGLDDSAFSLLPRAPAFSGFGTSLLSSKNNVPPGLGNWDNSCYQNSIIQGLASLQSLEAFLERNVDQLGQKVLLSTHQALRDIIERLNSAENYGQRLWTPADLKSMSSWQQQDAQEYFSKVVDQLDLEVQQATRRHTRNLGLKMAGPREHVIGSGLVQEVSGNDAPEPQTTGNQIFRNPLEGLLAQRVGCIQCGWTEGLSLIPFNCLTVPLGPKFEYDIRECLHHYMHLEPIEGVECAKCTLLRAQAQLVNLLKQLDDDEETPNATTDSPKISNALRSSAQERLQAVEQALTEEDFAEKTLSEKCHIPGKSRVSTTKSRQAVIARPPECLVIHVNRSLFDETTGMLRKNYAAVKFPKALDLNQWSLGGIPDNGNEQDLEGWETNPSVSMLSHVGRGVNIDRHYELRAVITHYGRHENGHYICYRKYSTETFPAHVPDAVMEADGDEEQSQRWYRLSDEDVQMVSEASVMSQGGAFMLFYEATDYSPEAAEEVNYGLLEEESSASTSNFTLSENMSTTSATAESTSDVSEATSIPATVKVEPCGEKPLLMSDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X817</accession>
    <name>A0A317X817_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative isoamyl alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_564218</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469809.1">
        <property type="nucleotide sequence ID" value="XM_025614404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X817"/>
    <dbReference type="STRING" id="1450535.A0A317X817"/>
    <dbReference type="GeneID" id="37116547"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016462514" evidence="6">
        <location>
            <begin position="21"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="115"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="602" mass="64146" checksum="7521FC42E523595E" modified="2018-10-10" version="1">MFPTIVSALFLAVTASASSACKVTPYDPAWPSNADWAALNASIDHRLLSTVPVASSCWTGNPFGSSVSCSAVEEDWANASWQSRFPESIDYPVYANNSCLPPTADGYLAERGCTTGGMPQYIVNATSEEQIATAMKWAADRNIRIVVKGTGHDLNGRSSGAFALSIWTYNLRKLVRNTSWRNPSTNASQDVYIVGSGQQWGNVLDLALEQGRVVTTGQDPSVGLGGYIQGGGHGPISRTYGLAASHVLQMRVVTTEGQILVANDAENQDLFWALRGGGPGLYGVVTEYVIRHHPVPHNVIMGNVLIGPKDGSNASAEKSWDAAVRHLSALPDLMDAGVAGACMVATGEMAMSFASLKESTTGVVIKQVFWSFNSTPAAMEALVNPVLANITQAAGNNSLTVSFSASNSGNYSSFYSAISGSEVAGGQSLVSSRLLGRAELVDTPFQKQKGYLKIAMRSQNSTAGTYATVGLQGGPGVRDTPLTAWGAILPAWRSAYLHFISNGATVDPVAAGSPKLALESAARYNEAKEEMWREWSPNSGAYMNEANPYDSNFKHDFYGSNYDGLVQIKAKYDPSESLFVLSSVGSDKWQYDLDSGRLCKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X821</accession>
    <name>A0A317X821_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_610138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471440.1">
        <property type="nucleotide sequence ID" value="XM_025616604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X821"/>
    <dbReference type="STRING" id="1450535.A0A317X821"/>
    <dbReference type="GeneID" id="37118747"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016451415" evidence="1">
        <location>
            <begin position="29"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="332" mass="36499" checksum="89B09BC8DE9D9F0C" modified="2018-10-10" version="1">MVARHLAHHNYTVAWVCVLACEVDAARALLDEEDDPLEPLFGDNNVYVLGRMWKLNVVIASPSIRGDTPMGQAVAHLIRTFHNIRFGLLVGVGGGAPDLAHLDPSNDIRLGDVVVSYPTGKHGGVINYNAPSWKDENSPEIESRLTAPPNALMSGVERLQCDHRFSKGKEKMLSNVEVAFTRLTEVHHYPIHYSVPGHDPDQLFNAVYNHVGGKSDCGRCDPGEIIKRAQRTKDEPQVHYGLIASADRDVNSTKLRDLLRNSWGVACLEMEAGGSLIDFPCVFIRGISDYCDTHRSDEWQPYAAASASAYAKDLLRLMGPEQVGGIRLAQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8U2</accession>
    <name>A0A317X8U2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_507790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471730.1">
        <property type="nucleotide sequence ID" value="XM_025609633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8U2"/>
    <dbReference type="STRING" id="1450535.A0A317X8U2"/>
    <dbReference type="GeneID" id="37111776"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000045">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY94969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="531" mass="57159" checksum="CB2A8B42E92EEE92" modified="2018-10-10" version="1">MASFGNPTQIFADDVIEEKGENARLSAFVGAIAVGDLVKSTLGPKGMDKILQSASTGDILVTNDGATILKSIALDNAAAKVLVNISKVQDDEVGDGTTSVTVLAAELLREAEKLVNRKIHPQTIIEGYRIASKAALEALEKVAVDRSADMESFRKDLHAIARTTLSSKVLAQDRDQFATLACDAVLRLRGSTDLSHIQIIKKAGGKLSDSYLDEGFILDKKIGVNQPKRLENVKIMVANTAMDTDKVKIFGARVKVESTGKLAELEKAEREKMKAKVERIKSHGINCFVNRQLIYNWPEQLFTEAGIMSIEHADFDGVERLALVTGGEIASTFDHPDQVKLGHCDVIEEVIIGEDTLIKFSGVAAGQACTIVLRGATEQLLDEAERSLHDALAVLSQTVKDPRVTLGGGCAEMVMSKAVEQAAQNTTGKKQLAVDAFAYALKQLPTILADNAGLDSSDLVTRLRQAINNGMTSSGLDLLTPGGGIADMRELGVVESYKLKKAVVSSASEAAELLLRVDNIIRAAPRRRERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8V3</accession>
    <name>A0A317X8V3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_542308</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471794.1">
        <property type="nucleotide sequence ID" value="XM_025613087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8V3"/>
    <dbReference type="STRING" id="1450535.A0A317X8V3"/>
    <dbReference type="GeneID" id="37115230"/>
    <dbReference type="OrthoDB" id="10626430at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="232" mass="25951" checksum="2196AFE2CEBBF763" modified="2018-10-10" version="1">MEQQPAPRKKFTLIGNHSKDVIGFPKTASGSGNAVLSEMRGGVHLLRYFLKNLLGLDEDDDMNPGSGQPNSFIELFKSKRKDENDVEKEYYQVRRHLHVEKNPPSRIQEPLENNPEGADIDDVMIIMLEEPCAPNGGSFGEGNVLRVGPVRDTNLNTTITTFTGVLVCKMPYPSYDGPRGQSPLMEAFKTRANNNRDTVIIIDADDLRRKGAKISRHLSWAKTAEDLDKFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8W8</accession>
    <name>A0A317X8W8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tetratricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_318633</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470843.1">
        <property type="nucleotide sequence ID" value="XM_025606892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8W8"/>
    <dbReference type="STRING" id="1450535.A0A317X8W8"/>
    <dbReference type="GeneID" id="37109035"/>
    <dbReference type="OrthoDB" id="411857at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000266">
        <property type="entry name" value="Pentatricopeptide repeat domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057585">
        <property type="entry name" value="TPR_dom_fungi"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24603">
        <property type="entry name" value="TPR_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="358"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Tetratricopeptide repeat" evidence="7">
        <location>
            <begin position="484"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="969"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="1004"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="777"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="786"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1271" mass="138960" checksum="7A3857E9E1E90AE7" modified="2018-10-10" version="1">MVFKPFTHLARQSFTKAFTHGYAQSVVAASQSSYASTTTFNQLANQPAKLSRTALQNVFQPSSSSGAGAKASQGTSGSGDLGLAAYYAAWQHAQQTGDDSDWKQLQLTRKVGWKPPLNEDGVKSKDADNLPSSDNFQNSPHITKASANADVSAKVEEAVAREIQIQEEQAQAEEASEAKENTDTEAFPELPPDVAAVADATTEQSRLASEHITELASSKKYADIPGAFATLLRDGLTPTVGAYNALLESAIELHGDTAQAIQKALDVYSDMLRRRVVPDEQTYQTLVQLFVVHANETIKSKGLLEQERVRYGGMEEPGKFMLHSSELERAILAEDHSLAIALKLFNTAAARHADLVFPLDTYRYLITACATEGQVEDMVRVYAHMESHKVTPHASIFPSMIDAFASTGDLQSAVECYNEYKSLAVSDDNGTFCIVQRLDGEVYAALVRAYLVCGKEQQALRFLDRIGASFEEVTENREARQTALESAVVQDGLVRHALKSGEHGRALEQAKTRLHDGALDHAMSQICIAAADAGNLQTASEAYDALPTDMALRQRPAVSMLALHVRQGNVSAARAVWLSLSTAGQATPDMVQPTAMYAVALLKSGQIEEALVQARNMFARIRNSSASDIHSTLNPIREQINESLHLLGRVLVQTAAVLSPQAAMSLLWSMVENGGLISPVAEHVVASLGPIGISQLNSRDLMLALQVQAGMLVNNSAMFDVAHPIRFSHMLDIALATGLPMDAVTTRLVDQAVGKLFNSRPDMVKRWHDHLALTSSPSSFVSGRHSPSSDMSTMSPVSSEDSFDPYAYATDFRGSSMIADELESTSGKPEAHLNDALSRVRNMRRNGRHPRYITYAKMITAATKCNRVDLGYEILSMARRDVPLLPQYSAVKYGWVSILDAMVASCLTLGDRSQASKFHQELLELGSAPSANTFGLYITTLKESTKTFDEATEALKIFHRAVAEGVEPTSFLYNALIGKLGKARRIDDCLLYFAEMRANGVRPTSVTYGTIVNALCRVSDERFAEEMFEEMESMPNYKPRPAPYNSMIQYFLNTKRDRSKVLAYYERMLTRNIQPTMHTYKLLIDAHASLEPVDMPAAEKVLETIKAAGQRPDAVHYASLIHAKGCVMHDMEAAHDVFKSVASNGRVRMQPCLYQALLEAMVANHQVSQTEEIVRDMSRRGVEMTAYIANTLIHGWATEGNVAQAKNVYDSIGLNKREPSTYEAMTRAFLAVNDREGASRTVQEMLSRGYPAAVASKIADLVGTGAAVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X907</accession>
    <name>A0A317X907_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DCG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_531730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HyuE racemase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471556.1">
        <property type="nucleotide sequence ID" value="XM_025610965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X907"/>
    <dbReference type="STRING" id="1450535.A0A317X907"/>
    <dbReference type="GeneID" id="37113108"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052186">
        <property type="entry name" value="Hydantoin_racemase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053714">
        <property type="entry name" value="Iso_Racemase_Enz_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28047:SF5">
        <property type="entry name" value="PROTEIN DCG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="31202" checksum="7C553CE03C976351" modified="2018-10-10" version="1">MDVPTKPRYTILVINPNTSSHMTNALIPILDNLGHGGIQFDYFTAPASESVKVHDGSYVEGVPSIDSGEDSVKSALYCMPFIEQLVTEYDGFIVACFSAHPLVGMLKEKVRSIEEAESSGVPSELKVKKKYVTGIFEAAVLAALGVISSFQTSSSLGFGKAQSRDKFGIITTGKVWEAELTKAVGDMLGNSGDFTSTGRFAGVETTGLTAVELHTTPPAEVRKRLVEATERLLKKSNCPVGAICMGCAGMVGMEDAMREGCVRAYGRERGNQVRIVDGVIAGAGMLATACKAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X939</accession>
    <name>A0A317X939_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_216000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471770.1">
        <property type="nucleotide sequence ID" value="XM_025606193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X939"/>
    <dbReference type="STRING" id="1450535.A0A317X939"/>
    <dbReference type="GeneID" id="37108336"/>
    <dbReference type="OrthoDB" id="4802432at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="499" mass="58074" checksum="6D071E281BCCE9CB" modified="2018-10-10" version="1">MDLLPYEILCKIASYLAYSQDPERKPFYASGPWDSPNLALYSTISRKWQVVVEHIIWEWVLLLKADSTAKLAEYTRGSPARHARVGYIRHILWEVQVSTSQIEQTFHDHFWDRAKKLVACHTQQFCISLLPLFQVLHSWDRQNPGLELILSECEPVSLPFYGREAGNNVSLYDMKHLYVAGRHPMMFYLTAKNLKRFPKPRCITSLQISKITPLFIWPSAVLQIVNILPNVNDVSFINFVWEDTFHKALSDLREDTAKHLAQVPRSVETFRYTSCFSQRHCYNPTGNSINCLMGSDKLDNHSIALRKFSTQLRELRLHNVRISSALFWPSGENDTDTPYWPKLEVIKVLDIPPLNADGTWMIHNDPLKVVGCAELARQMWAAWRNPYSAGRWYGQRGLIQSTEVDTLYQAMGKAAHQMPRLRLLESSFCTESDVSRECLRFERDDLTGHGHLIITTEWKYRLGEEVISAWGLEGKKAEEFRRTWNVRYPWHPCRSDKWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X971</accession>
    <name>A0A317X971_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Enhancer of mRNA-decapping protein 3</fullName>
            <ecNumber evidence="8">2.3.2.27</ecNumber>
            <ecNumber evidence="9">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BO94DRAFT_563626</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the EDC3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="8"/>
    <dbReference type="EC" id="5.2.1.8" evidence="9"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470908.1">
        <property type="nucleotide sequence ID" value="XM_025614368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X971"/>
    <dbReference type="STRING" id="1450535.A0A317X971"/>
    <dbReference type="GeneID" id="37116511"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10260:FF:000007">
        <property type="entry name" value="YjeF N-terminal domain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="entry name" value="YjeF N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13612:SF0">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="YjeF N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16 27" id="KW-0413">Isomerase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0697">Rotamase</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DFDF" evidence="25">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="YjeF N-terminal" evidence="24">
        <location>
            <begin position="434"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="26">
        <location>
            <begin position="726"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="23">
        <location>
            <begin position="1003"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="157"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="298"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="871"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="913"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1171"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1242"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="22">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="22">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="22">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="22">
        <location>
            <begin position="934"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00015797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PWY94147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1267" mass="137968" checksum="9BA3CFDCED38984B" modified="2018-10-10" version="1">MASEFIGYNVLVSLRAPPNATVQGQVANVIGQRLMLRNVTLSWLGHQLPEYSIEAPDIADLSLGPSTQPIAQRPPPPAPAVPPAPHSFVDPAILSFSKPPYVPSAQGTESGPAQLPAPSISRSTSQTFQFPQLAHRDQAAVLDEPFSNLELDVGKSGEKSLKAGQSGSVPGGRENLNSSQPTPQTGPKANRRTGQPRTPKPVNEHDGATNTDPKSKGWRQTAFVEPSYLHLNRSLNKQRRKKKNKANYAEDPNGWATEDATDIQEMGEFDFQSNLSKFDKRKVFEEIRNDDTTADEDRLVSFNRKPPKPGTNGGKNLHWTENVLDSLEETESEDTDQVPSDAKLSSGTYSGRERSRASRASSSRKGSAILGQPLVPPQINTLGRGQLSTSRTTSPRPNKSSVSASPISGPGAPGASLRLTTTNRSCPTVSPLQTLEVEQIAVAELGLTEDMITENTGRGIAEAAVGLLSSDAAAPTMLVLTGNHRTGARAVSAARHLRNRGHRVTVCMLGIEHENELLESCRKQLEVFKKIGGRVHRWEDLSTRLSTSEFAPDLVVDALFGIHIAFDDLRTDDQATAFEMISWANRSNLEILSVDVPSGLSAMSGEATTVEGGRLCINSRSVVCLGAPKTGIVNALLSGEGLSWNLSVADIGIPQIVWRKYGSRRRHGIDFGNRWVVPLRYQPSPTPTINGLLITHSEWASEDAFSASAGAGVGRAKRGGVDTAFKRLPFNFCSLSLQPFSHPVCTPTGTIFDLTNILPWIKKHGTNPVNGAPLKASDLIKLHLAKNESGEYVDPVTYKVFTDNTHIVALRNTGNVFAWDTVERLNIKGKLWRDLVTDEEFSRKDIITLQDPQNIESRNLSSFNYLKEGESGLTDEQIREREDPSNNVNVNALGSSAKILKAKEAVAKARAERAQRVGSAATAKELSKTGGTGNAAQSQKTASYQSGKAVPYNAARHTTGLAAASFTSTGMTPHTSAELALLSDEEYMLKRGRVKQKGYARISTTAGDVNLELHTEYAPKAVWNFIKLAKKDYYKDVTFHRNIRGFMIQGGDPSGNGRGGESIWGKYFNDEFEGPLKHDSRGTLSMANKGKNTNSSQFFIAYRALPHLNNKHTIFGHVIDDPTPSSTTLNNLEMHPTNPTTNRPTPDVRITDVTVFVDPFEEFLKQKQTEEAKAKGQVVNPEEEEQNARRAEDDRITWTGKRVRGSGEGAKEEGSGGVGKYLKAALAERAGQEEDEIVEFVDDEPEPEPTRKKFKGGGGFGDFSSWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X988</accession>
    <name>A0A317X988_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_456534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471935.1">
        <property type="nucleotide sequence ID" value="XM_025607705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X988"/>
    <dbReference type="STRING" id="1450535.A0A317X988"/>
    <dbReference type="GeneID" id="37109848"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="243" mass="27755" checksum="03E2EE18D92E1B73" modified="2018-10-10" version="1" fragment="single">MRLLQVSDLKLLDFLPDSIPPYAILSHTWGKDEVLFEDILHHTAINKSSYVKVEGAAKQASANNLEYVWIDNCCIDKSSSAELSEALNSMFAWYENATVCYAYLSDVPTNVNVNDPGSEFTRSRWFTRGFTLQELLAPKEVIFFSSNWEVIGKKTELYEILSTITGIGVQYLRHKAPLSSASIANRMSWVANRETSRPEDIAYCLLGIFNINMPLLYGERDRAFIRLQEEIMRQSDDQSIFAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9L3</accession>
    <name>A0A317X9L3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_532986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470021.1">
        <property type="nucleotide sequence ID" value="XM_025611244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9L3"/>
    <dbReference type="STRING" id="1450535.A0A317X9L3"/>
    <dbReference type="GeneID" id="37113387"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000014">
        <property type="entry name" value="AflYg/ npgA protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="31"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="132"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY93260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="309" mass="34840" checksum="04A70288E08F78D3" modified="2018-10-10" version="1">MASTPDNKPPVLVRWYIDTRPLTAHITTLPLLSTLQPTEQEAIQKFYHLKDKHMSLASNLLKYLFIHRTCRIPWNQITISRTPAPHKRPCFIPSPTLSTLSTPIPTIDFNVSHQNSLVALAGTTYSHPNIAQVGIDITCVNERHGKRGPEPRTRSSFLEYATIFTEVFSARELSLIKSLTHPSGKYSLTSPEGIEYSYRVFFTYWALKEAYIKMTGEALLAPWLRELEFTNVIAPDAGEAYQYVKTSLYGKEVRDVRLEVMAFEEDFLIATAARGGEIGSRSGAWEGLVSIDIEKDVRPCAMVECQCLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9R4</accession>
    <name>A0A317X9R4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Involucrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_460436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470071.1">
        <property type="nucleotide sequence ID" value="XM_025607882.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X9R4"/>
    <dbReference type="GeneID" id="37110025"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053268">
        <property type="entry name" value="Woronin_anchor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641:SF2">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40641">
        <property type="entry name" value="INVOLUCRIN REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_2G08060)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="829"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="948"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1325"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1517"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2209"/>
            <end position="2270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2316"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2516"/>
            <end position="3049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3062"/>
            <end position="3957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3973"/>
            <end position="4462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4480"/>
            <end position="4713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4729"/>
            <end position="4976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="5004"/>
            <end position="5299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="5319"/>
            <end position="5604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="5637"/>
            <end position="5763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5763"/>
            <end position="5797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5826"/>
            <end position="5936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="712"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="762"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="838"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="871"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="892"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="948"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1221"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1374"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1415"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1431"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1565"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1625"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1641"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1679"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1710"/>
            <end position="1725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1740"/>
            <end position="1766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1767"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1789"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1823"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1901"/>
            <end position="1910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1955"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2012"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2025"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2047"/>
            <end position="2064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2075"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="2113"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2137"/>
            <end position="2147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2160"/>
            <end position="2170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2173"/>
            <end position="2182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2209"/>
            <end position="2235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2380"/>
            <end position="2393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2394"/>
            <end position="2408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2412"/>
            <end position="2421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2454"/>
            <end position="2471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2628"/>
            <end position="2639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2673"/>
            <end position="2686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2713"/>
            <end position="2727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2789"/>
            <end position="2804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2834"/>
            <end position="2854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2877"/>
            <end position="2890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2912"/>
            <end position="2923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2963"/>
            <end position="2992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3083"/>
            <end position="3096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3121"/>
            <end position="3134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3151"/>
            <end position="3169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3237"/>
            <end position="3248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3268"/>
            <end position="3283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="3284"/>
            <end position="3304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3326"/>
            <end position="3353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3374"/>
            <end position="3383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3389"/>
            <end position="3401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3425"/>
            <end position="3434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="3439"/>
            <end position="3453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3459"/>
            <end position="3474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3478"/>
            <end position="3488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3515"/>
            <end position="3526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3550"/>
            <end position="3567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3604"/>
            <end position="3617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3641"/>
            <end position="3654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3666"/>
            <end position="3680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3706"/>
            <end position="3716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3734"/>
            <end position="3743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3758"/>
            <end position="3777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3778"/>
            <end position="3789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="3811"/>
            <end position="3831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3855"/>
            <end position="3865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="3993"/>
            <end position="4006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="4106"/>
            <end position="4122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="4123"/>
            <end position="4141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="4202"/>
            <end position="4213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="4230"/>
            <end position="4239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="4317"/>
            <end position="4330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="4355"/>
            <end position="4364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="4377"/>
            <end position="4398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="4561"/>
            <end position="4571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="4589"/>
            <end position="4600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="4607"/>
            <end position="4623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="4704"/>
            <end position="4713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="4745"/>
            <end position="4755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="4781"/>
            <end position="4795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="4801"/>
            <end position="4821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="4896"/>
            <end position="4906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="4952"/>
            <end position="4974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="5051"/>
            <end position="5061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="5090"/>
            <end position="5100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="5131"/>
            <end position="5142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="5143"/>
            <end position="5154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="5178"/>
            <end position="5187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="5335"/>
            <end position="5346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="5365"/>
            <end position="5374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="5410"/>
            <end position="5428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="5473"/>
            <end position="5482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="5568"/>
            <end position="5589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="5649"/>
            <end position="5664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="5675"/>
            <end position="5686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="6251" mass="678878" checksum="C4643930CAF51336" modified="2018-10-10" version="1">[encoded data, 6251 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAH4</accession>
    <name>A0A317XAH4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_130467</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472345.1">
        <property type="nucleotide sequence ID" value="XM_025605640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAH4"/>
    <dbReference type="STRING" id="1450535.A0A317XAH4"/>
    <dbReference type="GeneID" id="37107783"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="357"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="305"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY95584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="429" mass="46671" checksum="669968B9742710BE" modified="2018-10-10" version="1">MTAKSLTTVATLFADPSNTTAPLNESSVFSLKLESTIQTLSEQNAPDKGPIQGLLFVPRLDEQNRCNNATAPFIPANVTRLQGVTQFGSRMIGLAPWVNDECTQAFLNASQDPTPDALVFFLPSNDDTKPPSANDPVWLLGGSAAWQSRSEFPVYAIPGAAGVTLMDQLSRDGTTNQTALAQMQSGVSQLMAVIDIDSGGSKMPSIWGFILAILGTILVLTIILLLFYQLVHKRHQRELQRRLEAGEADLEQLAQHHVKVPPEFLETMPIYLFSGPNASDSGSQNEIAPFREPLADIIEEGEVEDAASQPPAFANQVADDEPEKATDDESARRPSQSDPEAAYARHQNRLSRLQTTCAICLDDFVPMSSRVRELPCGHIFHPPCIDTSLMQSSSLCPLCKKSVLPGGWLAYSGIDTTMHNDPYLQTAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB68</accession>
    <name>A0A317XB68_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AdoMet-dependent rRNA methyltransferase spb1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_530606</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472635.1">
        <property type="nucleotide sequence ID" value="XM_025610708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB68"/>
    <dbReference type="STRING" id="1450535.A0A317XB68"/>
    <dbReference type="GeneID" id="37112851"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="234"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="578"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="433"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="550"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY95874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="794" mass="89798" checksum="571031DB8F545FD7" modified="2018-10-10" version="1">MAIQKKHGKGRLDKWYRLAKEKGYRARAAFKLIQLNKKYGFLEKSKVVLDLCAAPGSWCQVAAECMPAQSIIIGVDLAPIKPIPRVITFQSDITTEKCRTTIRQHLKHWKADCVLHDGAPNVGAAWVQDAFSQAELVLQSMKLATEFLVEGGTFVTKVFRSKDYNPLLWVFKQLFSSVEATKPPSSRNVSAEIFVVCRGFKAPKHLDPKFLDPKHVFAELAAPTPNNEAKVFNPEKKKRKREGYEEGDYTQFKEIPVTEFINTTDPIAILGSYNKLSFQQSPTGDLALATLERLEDTTDEIRSCCEDLKVLGKKEFRNLLKWRLKVREQFGLVVKKGSQAKDDEPEEVAEIAPMDEELAIQEQLLRLREKETTKQKKERRKENEKKRKEIVRLQMHMTTPMDIGKEQLGPNGEDATFSLKRAERGGVRDAIAAGQEATIESDSEDSESESETEESDDEEDRLERELDNLYEQYTDRKEDKDTKLRAKKARKGYEADEWDGFSDSDKEGSDGESDEEGVNSAFAGDKAQSGSLSNNASLFFDQDIFEGLEDIDDVEDEDSAIEVKEDRPKSKKSSEKQTAKDSKKKTVQVAEDSDDEFVELEEPRKKNGQLDIDIITAEAMALAQQMASGEKKSSDVVDDGFNRFAFRDVDGLPEWFLDDETRHSTPNRPITKAAAAAIQEKMRAINARPIKKVMEAKGRKKFKAAQRLEKLRKKSALLADDEALSERDKSQAIARLMSRATKKKPKQQVKLVVAKGNNRGISGRPKGVKGKYKIVDSRMKKDIRAQKRLAKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB70</accession>
    <name>A0A317XB70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD-repeat protein Mip1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_541859</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472520.1">
        <property type="nucleotide sequence ID" value="XM_025613063.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XB70"/>
    <dbReference type="GeneID" id="37115206"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000514">
        <property type="entry name" value="TORC1 growth control complex subunit Kog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000194">
        <property type="entry name" value="WD repeat-containing protein mip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000278">
        <property type="entry name" value="WD repeat-containing protein mip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="179"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1324"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="924"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="975"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="975"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1450" mass="163472" checksum="A1E909897F993E9F" modified="2018-10-10" version="1">MEHAVQQQASNPEPRKSHHKSVRVAFGPDLETHIPPRDRSPAPVPGHHRSFTTVEPKQPPVITPERPTSSSAGENPALIESNGRLISDRASDSARPSMLKRARSDYGPRVGLDKSFAGDEEEDIAMRHGWQEEYTSSEYLKVLHSNFYMYFTEKRHETNGIPRDPVGSWPSQDWRMKDRLKTVSAALAICLNIGVDPPDVVKTNPTAKLECWVDPTSTTGGGHNKIMEQIGKKLQEQYETLSLRTRYKQYLDPSVDETKKFCISLRRNAKDERVLFHYNGHGVPLPTQSGEIWVFNKNYTQYIPVSLYDLQSWLAGPSLFVFDVSHAGNIVHNFHTFVDKHEKENVEAKKRDPNAIVQNYGDCIILAACQKAESLPTNPDLPADLFTCCLTTPIEIALRFFILQNPLQTNISIDDFRVPGRLQDRRSPLGELNWIFTAITDTIAWNTLPRALFKKLFRQDLMVAALFRNFLLGERIMRTYKCHPISSPELPETHHHSLWKSWDLAVEMVLSQLPALIDHEEGRRQYEYQHSTFFAEQLTAFEVYLSSGPTEKNPPDQLPIVLQVLLSQAHRLRALILLSKFLDLGPWAVHLALSIGIFPYVVKLLQSAAQELKPVMVFIWARIMAVDHTVQNDLLKDNGIHYFISILNPSSPIPVGNASEHRAMCAFIVSIFCKNYPQGQNVCLSSELFDSCLKHLMDVENPLLRQWSCLCISMLWSDFPEAKWMGIRCAAPARLCELNFDPVPEVRAAMLHAVTTFLGIPDLTDQVAQIEESLAMAVLPMSSDGSVLVRKELLVFFSTFVRRYQNKFLVAAYEEFQDEKQNLLLKLEQDGTRSLYLEDVPNVSANGSTDPSHRSQTLSRNTTFGTIWKQLLILSVDPHPDIAQDAGMVVDFIHICLLQSPMASLTNKIRNEILDLSSRISQKFQVRERPESKKAAPPPTPPSVAPPKQEGYLSLSLKRTASVAASLKNLAFGNSSPAEAQSQQASTAPKNRVPMTPRGRAPPEWTRPPEVNDQVAPATAYHQAPTPTSRGFEPRDPSANPTIPLMSRFLDWSTEVILELFDLMSAKNHLEYEQLLTPIQYFREPQMKPNEPDEPGSADYNERLWRRSRNEKIIAETQPLKGVAGSSRWDNSLSLLSNSSQPLKMCFHQFEDHLAVADDRDTIAIWDWQSHKRLNRFSNGNPAGSKINEVRYINEDDQALLMTGSSDGVLKVFRNYESSKNVEIVTSFRALPELIPSNRNAGLVLDWQQGQGKALVAGDVKVIRVWNAATEVCTNDIPARSGSCITSLTSDQVAGNIFVAGFGDGAVRVFDQRLKPTTSMVKVWREHKQWITNVHMQRGGLRELVSGSRNGEIRLWDLRMDMPISTFSATRDTLRTLSVHEHAPVFMVGTNRHEVKTFNVDGSYLSTFEPYSSFLHHNRSSPIASTAFHPHRTLLACAALNDNHINLVNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBD5</accession>
    <name>A0A317XBD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioesterase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_456481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471678.1">
        <property type="nucleotide sequence ID" value="XM_025607703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBD5"/>
    <dbReference type="STRING" id="1450535.A0A317XBD5"/>
    <dbReference type="GeneID" id="37109846"/>
    <dbReference type="OrthoDB" id="2532955at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052389">
        <property type="entry name" value="Sec_Metab_Biosynth-Assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110">
        <property type="entry name" value="CHROMOSOME 23, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38110:SF4">
        <property type="entry name" value="THIOESTERASE-LIKE SUPERFAMILY-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="1">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="2">
        <location>
            <begin position="167"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33808" checksum="A0AB8C43D1F7B5B2" modified="2018-10-10" version="1">MSSRQHPCLLDVVSSVSSVPGSPNQFTVKITRDWCTQHSVLGGFLTAIMLAAGQRFLDQELGAARYPDPVHAFVQFLHMAHPGPSIITCTLLRVSSKHCVIQVELARAPTSTEDLDSLPVATLGIFTYGDIRKEKGLSQESRSTITRPPPDRRTECVTINDPVVYATPVTAKMNWVAPRSPDGLWGHRLGGHNRELWLSFRDGSRLSDILHLAYLSDLPLQPPATHIPDFYTKYAISTLCLSIEFKRRPDPSTEWVMIRSNSNKVSNGRYDAALQLFDEKNNLLALSHHVVFTSDLKPRPARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBG6</accession>
    <name>A0A317XBG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_530646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472667.1">
        <property type="nucleotide sequence ID" value="XM_025610716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBG6"/>
    <dbReference type="GeneID" id="37112859"/>
    <dbReference type="OrthoDB" id="4403049at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="338" mass="39296" checksum="4A487CED945C85BC" modified="2018-10-10" version="1">MTSPTDADQTMQQSLQRFRNRMAAANRKFIQDRIDEIEARGLATERQKWRKMVEYRHFDMPDENEDLPKRLVDLPTVVDTDPFAMDGVHPPRLRTEKAREIILDTLQQVFQRQAEKWAAEQGKDTPGLIPRCDELGMFLKYAHAVEDPDFRLSSIPPFEAGLWVMGADEAELVETQPERYYERVRAECERVRENLEDDDGIGDLINKSMVAPRIEGSDLEVKAGVITGTGYIDEYPHWFSAYLYCRQRVDADEGNDTISDAPNIQDWAWRVVVVDSEPDILNPTVMYGRRPQFDSIPEFLDWYCSWPDHLDTRGILSLRRHAIQCETDCESDCEYHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC02</accession>
    <name>A0A317XC02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome maturation factor Ump1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_572592</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470831.1">
        <property type="nucleotide sequence ID" value="XM_025614930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC02"/>
    <dbReference type="STRING" id="1450535.A0A317XC02"/>
    <dbReference type="GeneID" id="37117073"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="169" mass="18391" checksum="C6C0FC0AF22D0A06" modified="2018-10-10" version="1">MSLRIAPAPTHATQTTNTTTHDPITLPHPSKGAPSAPGLPDTLRDNLTLPAARGPPSSNTAIPSSAHPLEARLLAWRATQDALKMESLRRAYGIAEPVRRGMELKIVRDGSFRPGLLGGAAGGENLHEEILVLGGRDAEVAWEDVFRGNEFREPPAFHDEMEKRLRMDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC33</accession>
    <name>A0A317XC33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="11">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_530634</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472656.1">
        <property type="nucleotide sequence ID" value="XM_025610711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC33"/>
    <dbReference type="STRING" id="1450535.A0A317XC33"/>
    <dbReference type="GeneID" id="37112854"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="183"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="407"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="462"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="708"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="715"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY95895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="777" mass="86569" checksum="4EB0E4B8BE236497" modified="2018-10-10" version="1">MADDGLLLNFTLPDTTVLNHEPKKVKGGTWRDRLSAKKIAAHRTTHPRGDKPANSNNNNNENVRNPNRIQVTGTRPVKRQRVDEGGHSQQPGHGHQHQHQQQTGPRQFVSSLFTKNPAPRNNEDEEEKKKGEGEREETKPTNAPLIDGLDTFTNLGLSAPLAAHLLTKLEVKAPTAIQKASISQLLKEESDAFIQAETGSGKTMAYLLPLVQRIMTIAKDQKQREEGGMVQRDSGLFAIVLAPTRELCKQISVVLEGLLRCAHWIVAGTVIGGEKKKSEKARLRKGLNILVATPGRLADHLENTQALDVSNVRWLVLDEGDRLMELGFEKELAGIIQKLDARQRPSRIPGIPAKRTTILCSATLKMTVQKLGEISLKDAVHIQADPADEDGEPRKKDEDDAFRVPAQLKQSYAIVAAKLRLVTLTAFMKRTFMRKGSVMKAIVFVSCADSVDFHFEVFTRKQGEEEEKKDEEEESGDSDDEGAEEKRKRLEASAHGTIAPATAFSNPSNPVTLHRLHGSLPQHVRTATLNAFARNREPSVMICTDVASRGLDLPNVDLVVEYDPAFSAEDHLHRIGRTARLGRDGRALLFLMPGCEEGYVDILKKGYRDGGKALTRTDADDILKRGFGGNVESQNTDWEEKATEWQLDVERWSLENKKYLEMARRAYQSHIRAYATHIANERSMFNIKELHLGHLAKAFGLRDRPSKINVPGLRQGKDDIKKDFKAERKPVAGNKRKAAGRDDDDDAPPPTDMQMAARKMRAKMRENMAGASEFNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC60</accession>
    <name>A0A317XC60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_581232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472860.1">
        <property type="nucleotide sequence ID" value="XM_025615388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC60"/>
    <dbReference type="STRING" id="1450535.A0A317XC60"/>
    <dbReference type="GeneID" id="37117531"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="6"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="215" mass="24253" checksum="C05A249CA6D0BACA" modified="2018-10-10" version="1">MPPPPPLVPDGWKAEFDDRYQEWFYVNLYTGRSQWQRPDRPAQPEGQTPPPTGPPPSYETLSQDRLGQARDPRDRPDRYSPRPPSQSNYPANRDGYGYPQPQYGYNNNPYPQQYGYPNQYPNQYPNQYPNQYPNQSPNQYPAQYQNAYQQPPPPQQNQKHKKGMGKMGAAALGVGGGLLGGFLLGEGIEALEDDFAEPPPPGPDFDDFGGDFGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDG6</accession>
    <name>A0A317XDG6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-ketoglutarate-dependent taurine dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_2913</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472972.1">
        <property type="nucleotide sequence ID" value="XM_025606689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDG6"/>
    <dbReference type="STRING" id="1450535.A0A317XDG6"/>
    <dbReference type="GeneID" id="37108832"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF30">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE (AFU_ORTHOLOGUE AFUA_7G06030)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="88"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY96211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="376" mass="42777" checksum="CBF201BA9C1CD584" modified="2018-10-10" version="1">MPSSAPVLRPKKAQPINAHKEEEPISYDINIPYVDVTKESNSRTRYPEYLPTWDKVWFDPLPPFEYQDPALRVTDKSKRNLLSPGTKVTEIQPRIGSIVEGVQLNQLSDAAKDELALLVAERKVVAFPNQDLIDDGPAAQEAFMRHFGKPNYQPVSGSMRGHPGFHIIHRDGNREEITRFLEQRTTTTLWHQDVSYEIQPPGYVMLGLLEGPEVGGDTVFSATDMAYKRLSPTLTSWLDTLRAVHSSAKMINHARLTGSLVRKEAVDTVHPLVRVHPVTGEKCLFVNGEFITKIPGLKEPEQRWLLDFLMQHIITGHDFQARVRWQPRTIVIFDNRCTTHSAIVDYLDDDNGAKLRHIFRLCALGEKPIPVYDQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE97</accession>
    <name>A0A317XE97_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mannosylphosphate transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_543142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471651.1">
        <property type="nucleotide sequence ID" value="XM_025613122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE97"/>
    <dbReference type="STRING" id="1450535.A0A317XE97"/>
    <dbReference type="GeneID" id="37115265"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF28">
        <property type="entry name" value="RIBITOL-5-PHOSPHATE TRANSFERASE FKTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016389207" evidence="5">
        <location>
            <begin position="22"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="101"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="289" mass="33636" checksum="4856C736FD91BA5E" modified="2018-10-10" version="1">MIPRGLLALVTCAIWSTVATAYPNPADHSTHGSFINRNAPDPLWQKYGLNRSDEFKYFHEPGRDDTLGHYDSRFFQGEPVPDAERSITLTHMIRAYLNFFEDNGLETWIAHGTLLGWWWNGKIMPWDWDIDTQVMDTTLLHLADRFNQTVVQYTTTNPTVERRYLLDVNPWARQRDRGMGLNIIDARWIDISTGLYIDITGLSRLQADKPTEWECKNGHKYETQDIYPLRTSTFEGVTAKVPFRYDAVLTEEYSKTALTATQFHDHTWDPTLEEWVPDEPAAKDDRQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEU3</accession>
    <name>A0A317XEU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Probable ubiquitin carboxyl-terminal hydrolase creB</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbon catabolite repression protein B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Deubiquitinating enzyme creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin thioesterase creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Ubiquitin-hydrolyzing enzyme creB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-specific-processing protease creB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_542414</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Also plays a role in response to carbon starvation and the control of extracellular proteases activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with creA, creC and qutD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471911.1">
        <property type="nucleotide sequence ID" value="XM_025613091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEU3"/>
    <dbReference type="STRING" id="1450535.A0A317XEU3"/>
    <dbReference type="GeneID" id="37115234"/>
    <dbReference type="OrthoDB" id="27652at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000075">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase creB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="18">
        <location>
            <begin position="94"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="70"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="473"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="527"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="664"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00041870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00041962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY95150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="711" mass="80141" checksum="471E02A3A9A27DB4" modified="2018-10-10" version="1">MTPLEKMLQDMGSVREDGSDKFFGMENCLYYSVPFREAVINYPTRTPIESLEAALAKNLRYQNAAANLEAEAQAEKQKAANAQRPGAPPSQPQKPEDKESPEYKKKMALQTLPLLETKNNAASYGMSESLFTSLKDIFESIVGSQSRIGIIRPQHFLDVLRREHEMFRSAMHQDAHEFLNLLLNEVVANVEAEAMKQPIPSLPPPETAESSQQSVSSGSKTPNTTRWVHELFEGTLTSETQCLTCEKVSQRDEIFLDLSVDLEQHSSVTSCLRKFSAEEMLCERNKFHCDNCGGLQEAEKRMKIKRLPRILALHLKRFKYTEDLQRLQKLFHRVVYPYHLRLFNTTDDAEDPDRLYELYAVVVHIGGGPYHGHYVAIIKTQDRGWLLFDDEMVEPVDKNYVRNFFGDKPGLACAYVLFYQETTLEAVLKEQELENMNSNVADSYETAVKQNGSLQPPGLAHVHSASQIPLHDEPQRHTGLRRAPTAPQLPTHTEHTGPESDAPSPAVAIPPPVPPIPEVQNPPLSPKKSDIQSKKERAKEEKERKAAEKELEKQRRREQEARVKENQRREEAELKAALEASKASKADEDRRHPPDNGKDSDSKKSGNGLSRLKRGSKSFSQRLGKDKESRASSSGLSSVPSAEPLTPNHVPPEHAQSFSPRKASPKESHIVHKPLVHDDEQDTLKSPKGDRAGHGKWRSFSIRKKSFSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFN1</accession>
    <name>A0A317XFN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit Sen34</fullName>
            <ecNumber evidence="5">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_530002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473378.1">
        <property type="nucleotide sequence ID" value="XM_025610579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFN1"/>
    <dbReference type="STRING" id="1450535.A0A317XFN1"/>
    <dbReference type="GeneID" id="37112722"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000008">
        <property type="entry name" value="tRNA-splicing endonuclease subunit Sen34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016690">
        <property type="entry name" value="TSEN34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059049">
        <property type="entry name" value="TSEN34_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13070">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26577">
        <property type="entry name" value="TSEN34_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017250">
        <property type="entry name" value="tRNA_splic_SEN34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TSEN34 N-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="8">
        <location>
            <begin position="209"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00059865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR017250-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF26577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY96617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="301" mass="33195" checksum="9BC04EC8605B17F7" modified="2018-10-10" version="1">MDIEPTLPIPISYIAGSYFLFSIDAVTYLRREYHICGVLSGTLPQIPQQNVFLGLPLKLMPEEARLLVEKGVACIVDEVKVQKDGMRSLMEEDRKKYLRELESQGQHAMRLQNDRKEQQREKALKKIEEKKAAKARKSEQPPVANSPGEGSVVDLFANDQGSDQASRRSSTAAPYGTAMGVTPATSYPPLPYESSAEQRLPLPDVPASYPLFAHLHSEGYFLSPGLRFGCQYLVYPGDPLRFHSHFLGVAADWDEEFDLMKIVAGGRLGTGVKKGFLIGGAEGSDGDPSSVRTFSIEWGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFV3</accession>
    <name>A0A317XFV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_530420</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472441.1">
        <property type="nucleotide sequence ID" value="XM_025610670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFV3"/>
    <dbReference type="STRING" id="1450535.A0A317XFV3"/>
    <dbReference type="GeneID" id="37112813"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TNase-like" evidence="16">
        <location>
            <begin position="82"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY95680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="283" mass="32583" checksum="7CE76C07C04B357F" modified="2018-10-10" version="1">MRWPPWASKPPSPDQQPPSTSSPNNDPSNNDIIDWHAFTEPRTLLATLILTTGILSAVHLHKHYLRRIPTAVDISPSYLRRRSILGQVTSVGDGDNFRIYHTPGGRLAGWGWLPWKKVPTSKKELRDRTIHVRLAGIDAPELSHFGRPAQPFSKEAHDWLTEYLMNRRIRAYVHRQDQYQRVVATVVVRRALDFPIPFRKRDVSFEMLRRGLATVYEAKFGAEFGGAATERKYRGAEWWAKTKGTGLWKGYRKKDGKWESPREYKTRMGLEDLGTVKEVEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWX6</accession>
    <name>A0A317UWX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleoside-diphosphate-sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_540638</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461722.1">
        <property type="nucleotide sequence ID" value="XM_025612955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UWX6"/>
    <dbReference type="STRING" id="1450535.A0A317UWX6"/>
    <dbReference type="GeneID" id="37115098"/>
    <dbReference type="OrthoDB" id="9975943at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY66524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="249" mass="26788" checksum="187CC8840A3D866F" modified="2018-10-10" version="1">MSLILTGATGLVGSGALNHLLSLPQGQLSRLYILSRRPVPMADNHPNVTVIEHQDFTKYSPELLSQLKGASGCIWALGISQTEVSKEDYVKITVDYPLAAAKAFSTLSPSFNFVYVSGEGATQSPGMFTPFFGGIKGRCEQALIQLSGESPSLKPYSVRPAMVDPTYDPQVLEPFLQRADQKTLPKKLLRGILGPTIRGTYPQAVSPTQDLGRFLNDLASGDGKPLSGDGVTGDGWIISNKAFRRYAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2Q7</accession>
    <name>A0A317V2Q7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_421818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461990.1">
        <property type="nucleotide sequence ID" value="XM_025607407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2Q7"/>
    <dbReference type="STRING" id="1450535.A0A317V2Q7"/>
    <dbReference type="GeneID" id="37109550"/>
    <dbReference type="OrthoDB" id="2958217at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY67641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15249" checksum="775310210AB0E1BC" modified="2018-10-10" version="1" fragment="single">YTHYWSVIDTESREWHQAWPQLVQDTWTIIERAGIALTGPPLYGHETTPLVCEQNGIMINGVGEDGCECLVLRKEETTVTSCMTLERPYDLVVGCILLRAYALAPGQFDLISDGYWEDWRHVRQFYAQLWPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V392</accession>
    <name>A0A317V392_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">pectinesterase</fullName>
            <ecNumber evidence="5">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_560949</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462218.1">
        <property type="nucleotide sequence ID" value="XM_025614188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V392"/>
    <dbReference type="STRING" id="1450535.A0A317V392"/>
    <dbReference type="GeneID" id="37116331"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000045">
        <property type="entry name" value="Pectin methylesterase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF137">
        <property type="entry name" value="PECTIN METHYL ESTERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016453578" description="pectinesterase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="11">
        <location>
            <begin position="169"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY68555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="397" mass="43271" checksum="692CA91E39F61964" modified="2018-10-10" version="1">MLFYGLFLVLQAILVHSAALRQSSSSSLTTAAREKCQITLQCPPGTLVVSTTEHPLSNFTSLQAAISSLPNDNSSQTILLLSGSYNEQVNITRSGPITLLGQQPDRSALTDAARNTVNLTFAGANQDSSGSLDNVWFSVMIVAPTLDASLTGSGTTGYPVPADTPFGNTNFRVYNIDFRNTFSEYSAGPAHAISFSRSNGGFYYCGFYSYQDTIYIGKLGSAYMYKSILAGQTDFLYGFGTLYVQSSQILLRSCGGGITAWKGTNTTVPNNYGVYIHDSTVRAANISIAPDIKESCALGRPWNALHRSIFANTYEDGSIEPSGYINWEDRWSANETLMAEYKAYGPGFNLTGREDSEVSVLLDSREYARYSDPERVFLFPDGKVGNVGWIDWEVVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4I1</accession>
    <name>A0A317V4I1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_297621</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462398.1">
        <property type="nucleotide sequence ID" value="XM_025606719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4I1"/>
    <dbReference type="STRING" id="1450535.A0A317V4I1"/>
    <dbReference type="GeneID" id="37108862"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000063">
        <property type="entry name" value="MFS multidrug transporter, putative (AFU_orthologue AFUA_2G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="133"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY69193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="594" mass="66861" checksum="8BBD31B6BD2E2BD1" modified="2018-10-10" version="1">MSSTERAERSRESIGICSGERFPSTEQSDGEDLEEEKLEGNVDGTFAPISARVPSHEDRLRRHQSASSHPLERSWSLNDGYSFHTTDEEAAAERVISRKEGGATDETDDLIVGWDENDPMNPRNFNLLRRWLVVIICSSGSLCVTCTSSMYTVTYDQITKEFNCSRLVATLGLSFFIWGLAVGPLFLGPLSEFYGRRRIYICSFTFFLIWLIPCAVAKNIQTLIICRFFNGIAGSAFLSVAGGTVGDLFARHELSAPMMLYTSSPFIGPEVGPLVGGFINQFTTWRWTFYVLLIWTGILLVLIVFLVPETYHPVLLRRKARKLRKETGDDRWQAPIEKLHRSVAQTVLRSIYRPLLLLTLEPMCLNLCIFSAILLGILYLFFGAFQLVFDTVYGFELWQRGLCFLGLFVGMLFAIFSDPLWRRNYVLLELEHEKAVGRSDDFQPEWRLPPGMSSPCIAQDGGSNRLNAAIAGGPLVTIGLFIFAWTIYSRVHWIVPLIGSAFFGAGTILVFSGVFTFLVDAYPTYAASALAANSFARSIFGGVFPLFGIQMYNNLGYHWATSLLAFLTLVMAPFPYIFFRYGNRIRQKSRFAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V528</accession>
    <name>A0A317V528_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_295382</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462360.1">
        <property type="nucleotide sequence ID" value="XM_025606710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V528"/>
    <dbReference type="STRING" id="1450535.A0A317V528"/>
    <dbReference type="GeneID" id="37108853"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="12">
        <location>
            <begin position="9"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="11">
        <location>
            <begin position="184"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="14">
        <location>
            <begin position="292"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="13">
        <location>
            <begin position="449"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY69155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="604" mass="67924" checksum="BBD594DC24205214" modified="2018-10-10" version="1">MASEAASQVSAGALSAIFDETKHQIREPIVQCVQIKPLPPQQNHQERYRAVFSDISNYVQTMLATQLNPVVSSGLLRKGCFVRLKSFQANSVKGKKILIILDLEVLQELGEADKIGEPKPLENKPDEDEKHQPTTISSNGFYGSKIPGAQMQTNTRVPSTRPVMAASHATIYPIEAISPYSHKWTIKARCTSKTNIKTWHNRNTEGRLFSVNLLDDSGEIRATGFNDQCDMLYDTFQEGSVYYISNCRVQIAKKQFTNLNNDYELTFERDTVVEKAEDQSDVPQVRFNFTTIGDLQSVEKDTTIDVIGVLKESMEVSQIVSKTTNKPYNKRELILVDNTGFSVRLTVWGATALSFNALPESVVAFKGVKVSDFGGRSLSLLSSGSMAVDPDIEEAHKLKGWYEAQGRDENFTSHASLLGATTSTMKSDRFKTIAQIKEEQLGMSEEAVYFSLKATVIYIKQDNMSYPACLSEGCNKKVTELDPGQWRCERCDKTHSRPEYRYIMHVNVSDHTGQLWLSCFDDVGRLMMGTPANQLMELLQTDEKAAGDVFQDANCRTWNFRCRAKIDHFGEQQRIRYQISSARPINYSEEASRLADLIESYTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5R3</accession>
    <name>A0A317V5R3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_539975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462461.1">
        <property type="nucleotide sequence ID" value="XM_025612810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5R3"/>
    <dbReference type="STRING" id="1450535.A0A317V5R3"/>
    <dbReference type="GeneID" id="37114953"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="67"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY69633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="302" mass="33385" checksum="5F638F97AACD50AF" modified="2018-10-10" version="1">MDISTPEKRHTYRTFLSTLFTLENTLKGHESTITYKEVEIPGPTGPLLATIFSPKHPRTDISTIPGILHMHGGGHSTGNRFMGFTVLEWVEKLGAVCMTAEYRLAPEHPQPAQLEDSFSALRWMSEHAEELGFNADKLVVCGGSAGGNLAAGVTLLARDRAGPAIRGQVLMYPWVDDGVEGCSMEQFGDIAPLTRADAAQASDFAFGMEREFADMYTVPLRAESFRGLPATFIDVGEADVFRDQDLKYAAALWRDGVSTELHVWPGSWHGFDVFVPEAEVSRRARAARLEWLRRLLDVPEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6Y7</accession>
    <name>A0A317V6Y7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_299172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462424.1">
        <property type="nucleotide sequence ID" value="XM_025606724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6Y7"/>
    <dbReference type="STRING" id="1450535.A0A317V6Y7"/>
    <dbReference type="GeneID" id="37108867"/>
    <dbReference type="OrthoDB" id="42525at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009784">
        <property type="entry name" value="DUF1349"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35332:SF2">
        <property type="entry name" value="REGULATION OF ENOLASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07081">
        <property type="entry name" value="DUF1349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY69219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="196" mass="21740" checksum="F2A114AD1467259F" modified="2018-10-10" version="1">MTKFTFANSSQKVPGDGILPAEFAIKAAPSTDAWSKPPSTDIFNAPILYQTVPLKSFKRVRVAFNALWQQNYDQGGLILVLNGPGGTRKWVKTGIELTRGRPHLSTVTKDKWADWSLQPVPSGGGAATLELVKEADNSLWIYLVEGIQKSPLREITWIFEEPEVQDFWVGLYAARPSKEGEDLVVNFGHLIIEATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V784</accession>
    <name>A0A317V784_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_590810</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY68000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462049.1">
        <property type="nucleotide sequence ID" value="XM_025616062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V784"/>
    <dbReference type="STRING" id="1450535.A0A317V784"/>
    <dbReference type="GeneID" id="37118205"/>
    <dbReference type="OrthoDB" id="4540587at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="8">
        <location>
            <begin position="73"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY68000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="442" mass="48015" checksum="B131F65F5208A68C" modified="2018-10-10" version="1">MLDYNMNDSRVTALLWGLTGADQDIPNLACVLCAPVWDCIRYVTGMMSATVIASECLSRGMCFCWAKCLPNGKYQGGYVAAPTRGIHDDVAVCDFSSMYPTIMIGANISPDAILTPAESLRSEGAVTWDGYSVSAVCSGRTARFSTVNKGVVPQTLQKLVDERRKHKASRPTRAMALKVGANSIYGSFVYEMSTLYSPSCSAATTAFGRWCLALSICVFEKCGLRVIYGDTDSCFLSGTNVTAAKYHGSLRDHCNAALAVLKCVLGFTPFRDMDMCLEGLHKRMLLLGKKNYAYMSSSGDVRYKGIPVARKDALGICRKVSKCTVDMILYGGSTQEAKSAIALMCARARDSCALSSLTLMDLSKVIRAEGGSCYTYVDFNGDPKNVKIEDASPEMIVQYSKAEIATRISKEVTRYTSAAGLGTVYDIMWVCPVFESLGYVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9D3</accession>
    <name>A0A317V9D3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_590392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462435.1">
        <property type="nucleotide sequence ID" value="XM_025616020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9D3"/>
    <dbReference type="STRING" id="1450535.A0A317V9D3"/>
    <dbReference type="GeneID" id="37118163"/>
    <dbReference type="OrthoDB" id="2103397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="295" mass="34338" checksum="1B0A85BBB059AF41" modified="2018-10-10" version="1">MADVPPYALYDRIFIALTMAWFDRLQKRVLTSVESNEELQKACEGFFNDAILESQVLNLAASEIKNVPEVFHLHADPDSKWWELSEEERTKPVPEYLDNIWTDCYSAGFLSFDSEYITMVLLALLSKRFISCQYTLQLRARTPLTLKNWQYENRTAKIKGKIGWTVWCNQRAFPRRDPETGERVEDDSYKVESSVTLADDPPTEETSRSSRLQSLWVAASLREWHFFRIDSDSTYSHKCYRTSIDLMDKDAFRKFDRLLNEVTSTNSPGLKKEVTDDEGDLVNIPIDEAGDLYWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VB33</accession>
    <name>A0A317VB33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">alcohol O-acetyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Alcohol O-acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_539523</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Displays enzymatic activity both for medium-chain fatty acid (MCFA) ethyl ester synthesis and hydrolysis (esterase activity). MCFA are toxic for yeast and this enzyme could thus be involved in their detoxification by esterification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:17229"/>
            <dbReference type="ChEBI" id="CHEBI:2571"/>
            <dbReference type="ChEBI" id="CHEBI:47622"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.84" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462962.1">
        <property type="nucleotide sequence ID" value="XM_025612715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VB33"/>
    <dbReference type="STRING" id="1450535.A0A317VB33"/>
    <dbReference type="GeneID" id="37114858"/>
    <dbReference type="OrthoDB" id="5954035at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004026">
        <property type="term" value="F:alcohol O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000137">
        <property type="entry name" value="EEB1p Acyl-coenzymeA:ethanol O-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="173"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00066969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00080774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY71564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="487" mass="54442" checksum="3341434FE28DF5BF" modified="2018-10-10" version="1">MSSVETPASLLLSSLSIPLLIAGLLVMGLFSWIRPNGRIAYYHAKDNNLLLAKKSGKSGSKGQVTLVDLCHTATPETCQLNPFLFNGHLQTAWTTVVFDNVPVYYKRWMFEADNPVFTGHFAIDFVVDPYEPSSDAHATDSQRKYTQPSGLPERTSFFSEDEYAALPSDDTKPMLVVLHGLSGGSHELYLRHVIAPLIKDQTWEACVVNSRGCSRTKITTGVLYNARATWDIRQAVKWLRKTFPNRPLFGIGFSLGANIMANYLGEEGDACELTAAVLCASPWNLEIGSMNLQSTFAGRQYSKVMGTSMRALFEQHVEQVSKNPRIDVDAIRNITYLHEFDRALQCATWGYPTEGSYYRDATSTDAMLNIKIPFFVIQAEDDPIATAKALPFQEITKTPYGVMMTTSWGGHLGWFEFGGGRWFVKPVLNFLNLMTKEVDLTIPFEVEDPENVPGRVAHHSGPDKDHDTTPKPEFNPTLRRLVMQLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCY8</accession>
    <name>A0A317VCY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_539357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463187.1">
        <property type="nucleotide sequence ID" value="XM_025612689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCY8"/>
    <dbReference type="GeneID" id="37114832"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY72234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="69" mass="7720" checksum="A6AC2C9F036F727B" modified="2018-10-10" version="1">MKALEWIASEEGGLDRPLSRRNLEPKLDTTKVEAGQLPVRLMCRRSNGRLVRCTWAPGSFPTVAPAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VD08</accession>
    <name>A0A317VD08_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_525626</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463099.1">
        <property type="nucleotide sequence ID" value="XM_025610315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VD08"/>
    <dbReference type="STRING" id="1450535.A0A317VD08"/>
    <dbReference type="GeneID" id="37112458"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY72146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="561" mass="63579" checksum="23F0593AF47C2D2D" modified="2018-10-10" version="1">MLAPRRKTRTTKSKTGCRTCRARRIKCDELPGACRNCTSTGRVCEGYDAYRLPVRRTRRDAGPEGLVLTQTPSGLRWKITSDERRCLSFFQHRTIPDLVGLYDSPLWQKLVLQLSHAEPVVYHSVVALAATHQALEVNKKPCFKQSSKNIWSQFALERSSKAVALLTQRRMSQDPQLQEVTLVSCLLFLTRELLCGNYDVASLHVLGGLKILKQLGIQRRISGTLISPVEQCVVEMFLHLQMQSVYYGTGAPLTVDDDFVYHQPYEDYLLIFRRLQDARQVFEPLLNTAFLFVASCRHRSDEELLAGYSNLEQKQLLLLSYFSRYLEQFELLYHGAYILLNQREQREADMTKLTCLSALLSLKTCLLSKDQLFPDYLTPECEALVSFAEAVVGRLQSHSLITLDSAVIAGLYNASYKCSDFSVRVRAIDALRSWQHWEGFLHSGITADILEESMRGDLLKLKQKRDTTGRCLPPGVSFITTPDGQGYARVPYRIGQAERERWISMETPASLFAAFSANKTSSKWACVRSLGTCSPAGRWAFISERGSHDGESRGRWVLFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VD11</accession>
    <name>A0A317VD11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_550249</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463206.1">
        <property type="nucleotide sequence ID" value="XM_025613485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VD11"/>
    <dbReference type="STRING" id="1450535.A0A317VD11"/>
    <dbReference type="GeneID" id="37115628"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000190">
        <property type="entry name" value="C2H2 finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="65"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY72253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="823" mass="91620" checksum="BC3354AE447D1CD2" modified="2018-10-10" version="1">MAPAAPSQATNSPAKKTSAPEKKYKCQFCNRAFSRSEHRSRHERSPMESPALIFAALIDTKERPFKCLKCRSTFVRRDLLLRHDRTVHAKDGGIPLVSEGRRRGGAGVQKTSPAPGPSKPSITIDPATLEQIEASSDGMVDLETAAMLMTDFQHKAAAAATGQANDRAESDRSYSPGRGSLLEPPVSYLSGNATLPQMPWDTLVSPVDTKHHPMGSPFVSQESGSESHTLSSVMDRHGAVGDALAPSLHSLVNSLPMSGNSTPNALSPYPSMTGPVSPVNYRRSPGPSQALTLPKAPQIANEIEHNMVVERLQNVDSLGVLPETFQLPSTPALNKYLSTYFNLYHPHLPFLHQESFKPTTASPPLLLAVLSIGALYTFERQHAFMLHVGSKMLVNQFLQHKDNFDSRKCPLWAMQSTLLNMIFESWSGDPKGLEWTCSIKSLLANMVAGNRYQLKLRTEAREGGQPTREEWIEDESCRRTYFAVYIFFGMLTLTFNHTPAMSFDEFDNLELPSSESMWNLDVSDDEAWRRSLASSSPLTVREAHDCLFQGEQTRYSAFATRVLINALFLQVWNHKRSFEALQDVVTEYKLRLALETWESSLDVCEPETIVVPLSTPQKGHPLIFNSMAVYRNTRARLEVDLKSIQEALRYHSSYEVAAAMTVAREKVKRSQEMNKVIQSCFECIEIAAVQGINWVAKTSATNWSVEHPLCGLDLMVILSLWLYRLEHDEEPATEAEMAIYNKVRNLFDDDAVDAFGKLSSTVARVWGNILDGVVVWGITKLMGESFKLHSQALVGYEDSLRVAKDQPIHPMPTKTLASVGTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VEL2</accession>
    <name>A0A317VEL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">malate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_589918</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 16">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462905.1">
        <property type="nucleotide sequence ID" value="XM_025615982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VEL2"/>
    <dbReference type="STRING" id="1450535.A0A317VEL2"/>
    <dbReference type="GeneID" id="37118125"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="148"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY71507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="330" mass="34565" checksum="46934E6465A3F24F" modified="2018-10-10" version="1">MVKAVVLGASGGIGQPLSLLLKACPLVDDLALYDVVNTPGVAADLSHISSVAKISGYLPKDDGLKHALTGADIVVIPAGIPRKPGMTRDDLFRVNAGIVRDLVKGIAEHSPKAFVLIISNPVNSTVPIAAEVLKAAGVFDPKRLFGVTTLDVVRAETFTQEYSGQNDPSTVQIPVVGGHSGATIVPLFSKATPAFQVPADKYDALVNRVQFGGDEVVKAKDGTGSATLSMAYAGFRFAQSVIKASKGESGIVEPTFVYLPGITGGEEIAKATGLEFFSTLVELGTNGAEKAINILDGVTEKEQELIQTCTKDLKVNIEKGVDFIKNPPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIW3</accession>
    <name>A0A317VIW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_559952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463426.1">
        <property type="nucleotide sequence ID" value="XM_025614111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIW3"/>
    <dbReference type="STRING" id="1450535.A0A317VIW3"/>
    <dbReference type="GeneID" id="37116254"/>
    <dbReference type="OrthoDB" id="8093034at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12614">
        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12622">
        <property type="entry name" value="RRM3_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000117">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000224">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000134">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated rna-binding pub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="777"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="825"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="90"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="183"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="309"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="544"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="596"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY73161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="864" mass="94402" checksum="7F927CCE0E5892BA" modified="2018-10-10" version="1">MADNVAVSTSSSLPPPQNPAAASNQQYDASQGNGQANPSHMPPPPRPPVVIPQNTNPIPTAITSPMSGNMMSPTSAGGFVRRAAPEPNKRALYVGGLDPRVTEDILKQIFETTGHVVSVKIIPDKNKFNSKGYNYGFVEFDDPGAAERAMQTLNGRRIHQSEIRVNWAYQSNNTNKEDTSNHFHIFVGDLSNEVNDEVLLQAFSAFGSVSEARVMWDMKTGRSRGYGFVAFRERSDADKALSSMDGEWLGSRAIRCNWANQKGQPSISQQQAMAAMGMTPTTAFGHHHFPTQGLQSYDMVAQQTPQWQTTCYVGNLTPYTTQNDLVPLFQNFGYVLETRLQADRGFAFIKMDTHENAAMAICQLSGYNVNGRPLKCSWGKDRPPTGQFDNFSGQQGNSGYNSNPTPYFPQYGGPGAPMTPQGPTPTQRGWDQSGMAGQGYGQVPGNAGYGRGQATPTSGWNQPNNANFGNGFSGYQAAWPRRASRAQLAPMEDASNGKGVALSLDNNEQLPGRVRSGSASSGHKRNSSGSLLSRLSFLRMIQATQNTPERSHSGIEPDNGSDFGSGLRGGRAMSNAIQQHRRTRRRRGSLRKTALLGTRLDYRDKKPARLPADALRTDLNGQPQRPGPSPLPSDSQIRPFADPTSPDNDTITQQSPGQQNRGGNSTWTLMDAPQRTRNTHRQQNQSKESILGDEMTTDDEDIISFPRSNSSTTAIAAAATTAGLHLLPASSSSDSYYALQADSTYRPIHRAKSPLATHSVDIASSSEITWDYSETEWWGWIILIVTWLVFVVGMGSCFGVWSWAWDVGETPYAPPELEDDPTLPIVGYYPALIVLTAVMSWVWVVVAWVGMKYFKHANISGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJS9</accession>
    <name>A0A317VJS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_539285</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463113.1">
        <property type="nucleotide sequence ID" value="XM_025612673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJS9"/>
    <dbReference type="STRING" id="1450535.A0A317VJS9"/>
    <dbReference type="GeneID" id="37114816"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY72160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="120" mass="13989" checksum="AE3090E8E9F0A19C" modified="2018-10-10" version="1">MSSKTQTPRFDILETPDGYTLEGEYPGIKREDVFIHFPKPSTIVIQGYVKPKDPFEGYEGRGWWVSERVTGKSYRAFIFPMEIDVERTVVKLADGILSIQVMKHDTGREKEWCAKWEMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLF0</accession>
    <name>A0A317VLF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_549757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463520.1">
        <property type="nucleotide sequence ID" value="XM_025613461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLF0"/>
    <dbReference type="STRING" id="1450535.A0A317VLF0"/>
    <dbReference type="GeneID" id="37115604"/>
    <dbReference type="OrthoDB" id="27975at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="5">
        <location>
            <begin position="1066"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="582"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="729"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1161"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="43"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="323"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="604"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="741"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="815"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY73768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1216" mass="133054" checksum="8848FD69EFA2D67B" modified="2018-10-10" version="1">MSPRGSNRRSDPANLGFESSNSTANIFLGGVRRSWMRDTMATGPPLASNASASPPRSTTTRSAPTSTAASGGPSGSPQRRARLRETPPRGPPVDLTTSTTTTTTTTATPSSSSVTTSSPSAAPPPPPPPPPPPLPPSGPMAQSDPLQPISTSNGRNEKESNLSRSFPTLPLASSTTIATAVRSVTCQTTALPSPDPSISCSQPSPISAIDRNGAPVGPSPLLTTLPSPPTGGTPPVSATRSNAPQTGLPTPTPLTHATTTPGGVQGTSPILRGPSERIGNTELHPHPHPRPQQPQSQLPSQSQPQPQPQSQPLISHDPRAGPQVSSWTSMPTSPVVQGHQQSAVMRPVPMLPIDVPLFKHWLEKLETFAAEATRNRTISEVVESPRIRLLQSALLDKDPVYLALHQMYCLSSYAPSELRKLPGFGREQEQGLAVVKQLLVDNRRLSGDFLRWCVNFPEPIQNLLARSWWRDALEQIMNSLVHLSRRWDTFEQVTRERGLPPLIEEIIMTFAIRSHVMQYNIFLALYRRLPGHRGEQNLFDIFNRDAKYTDDRLDSPNPVHAARAKKERDLILSMYHKALTSTTAQATTATSQPRIHSQPVESPLTPTSNLPPQTTPHQIMTMPPGSAVPGYETRRSSHASMPGNGPHPTAPSAAGPDPTMSIAPVPYHSHTMPFPSQIARTHSPRMAPVHQPQPPPHPPQVVYPSQVVPSKPENIHQAPLAIHMPGSVVGHPQMAFPPQTAPSHPTNTPVSPAISSPMSVPNLPPTPGSNPASSASAPPPRRRGRPPRSSQPNAQPLMRYRAMQPANQGSQPGPTQDPPPPPPPPSVFTPFFPRRAHFHLPIHDPIRCGTGCTRLIYVALSIGEQVMQLYQYLHSFAVHPTPLGQLACRFDWTFDLPKPAFERLAKVNQDGDKLRPARIITSGQQIFRLRCIQVDVSTETVPEHTWCTTETCWPNVLYMFVNEVEVFARRRQQNGKDLPLEITEQLRKGPNTVTIHVLRSPAEMRDQVYAAAIEILNISDLGSVVAAAQSLPASESQEQIYKRLTPDTDDELSIMSEDLVINLVDPFTARIFNRPVRGRLCTHQECFDHETYITTRASKSGRRSFREDWRCPICKKDARPQTLLVDGFLVTVHDHLSRTNQLDDARAIRVKRDGTWTLKADADTSTEQTSDRISRTASVSLKRKSSDSTTPASQKPKFESAPDNRVGNPEQVIMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VMY1</accession>
    <name>A0A317VMY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_549541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463912.1">
        <property type="nucleotide sequence ID" value="XM_025613453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VMY1"/>
    <dbReference type="GeneID" id="37115596"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY75285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="502" mass="54827" checksum="638C9D4DC194BB9F" modified="2018-10-10" version="1">MWLIVFNFLCSIFTFIIPVLSFLQVQYLQTPDSDNSTFGGRPGFNRNFNTQYTPHSVVDTSTTAYFCSEYERQLIQVNPWDRLRTVPGPDDRTLADVLQSGKLLGASPPLSATEKGIPFNIPVQAQVGRLYTIYWMWNTTTEVEGGFLVYTSCFDIEIIETSGDSPTTKGATSDVLSSTALVSTSTPSNLTNDFPTTKRTKSSLLSRTRVVSTSVSSYLTSYIMLNSSAVRRPTFSGSSQLSGETVCPSISGLNINMTSSPSLRSPSIAMTSKADMNSSCSLLQTTTHSKTGMITQSILGGSESTNRPFITPPWQRNSTLPISITGMNLPTSLCSTPRIGSTQTVRVNTGNMTEFDPPSLDLSIGDAVMFYPINGSFNLYNTTLDESCVGVTRLGDDIDGSVLYNVTSSKPAWFLGLQHDDGWYYCFPGSHFALNPGNESEQFSSTIRTTSYMSIARPDRHLSTTTVVVTDTFSGTTLTTSYLTIAEPYARTSTTTLVVTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VP07</accession>
    <name>A0A317VP07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BO94DRAFT_627416</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463775.1">
        <property type="nucleotide sequence ID" value="XM_025617420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VP07"/>
    <dbReference type="STRING" id="1450535.A0A317VP07"/>
    <dbReference type="GeneID" id="37119563"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="223"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="760"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1024"/>
            <end position="1171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PWY74582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1171" mass="128721" checksum="18D16E3A0CD53018" modified="2018-10-10" version="1">MVLATRCGQATSALLRQRCLAESRRSALALRPFSSQTTAHSTASSLRLKTPSPWRPQQLRSFSSALRRLASESSNAPSAESYLASGIVKPGSKLVDVKKVLVIGSGGLSIGQAGEFDYSGSQALKALKEAGVQSVLINPNIATIQTDHKLADEVYYLPVTPEYVTYVIERERPDGIFLSFGGQTALNLGVQMNRMGIFERYGVRVLGTSIKTLETSEDRDLFSKALNEINIPIAESIAVSTVDEALQAAETVGYPIIVRSAYALGGLGSGFAANPEELKNLSSRSLTLSPQILVEKSLRGWKEVEYEVVRDADNNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEEYHMLRTAAIKIVRHLGVVGECNVQYALQPDGLDYRVIEVNARLSRSSALASKATGYPLAYTAAKIGLGHTLPELPNAVTKTTTANFEPSLDYIVTKIPRWDLSKFQHVKRDIGSAMKSVGEVMAIGRTFEESFQKAIRQVDPQFLGFQGDKFENLDDVLKNPTDRRWLAVGQAMLHENYSVDKVHELTKIDKWFLYKLQNIVDCNNELKEIGSLFGLQKEILLKSKKLGFSDKQIALLVGSTEDDVRARRKSFGIRPWVKKIDTLAAEFPADTNYLYTTYNATSHDVTFDDHGIIILGSGVYRIGSSVEFDWCAVNATLSLRNMGKKTVMINYNPETYSTDFDTADKLYFEELSYERVMDIYELEAASGVVVSVGGQLPQNIALRLQETGGAHVLGTDPKDIDRAEDRHKFSQILDSIGVDQPAWKELTSVAEAERFAETVGYPVLVRPSYVLSGAAMNVIYSVDELKEKLLNASAVSPDHPVVITKFIEGAQEIDVDAVASNGKLLLHAVSEHVEPAGVHSGDATLVLPPADLEETVMGRVKEIAEKVAKAWNITGPFNMQIIKADVEGAQPELKVIECNLRASRSFPFASKVLGTNFIDVATKALVGRDVPEPVDLMSVKRDYLATKVPQFSWTRLAGADPFLGVEMASTGEIACFGKDVVEAYWASLQSTMNFRVPEAGEGILLGGDINNPALAQIVEYLQPLDFKFFAASPAVKEHLEAAAKVPVQVIEFPKEDKRALREVFQKYNIRGTFNLAKTRGKTLLDEDYVMRRNAVDFGVPLFMETKTALLFAQAMSQKLPRAEGIPSEVRTWSDFTGGKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPM4</accession>
    <name>A0A317VPM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_235641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463562.1">
        <property type="nucleotide sequence ID" value="XM_025606323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPM4"/>
    <dbReference type="STRING" id="1450535.A0A317VPM4"/>
    <dbReference type="GeneID" id="37108466"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="97"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="97"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY73810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="21863" checksum="E4F0064251B1C02A" modified="2018-10-10" version="1">MNFDQSPPTSKRIKTSISTNAPSHLLAQQQVNPFSRVPSFEGIPMPQPQIPPQNPRKRRASPSVSSTPTMAAPGATTATGDTAHEQASGVSEPVPKKKGRTNTPWTAEEEQRLKTMRDAGRSWSEIAKTFPTRTEGSVKKHWYKDMHYAEFAEDESIALREAIKEYEASKWKVIGQKVGKPAKACEQYAKEHFKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQS1</accession>
    <name>A0A317VQS1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_577968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463869.1">
        <property type="nucleotide sequence ID" value="XM_025615196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQS1"/>
    <dbReference type="STRING" id="1450535.A0A317VQS1"/>
    <dbReference type="GeneID" id="37117339"/>
    <dbReference type="OrthoDB" id="5401170at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY75242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26777" checksum="7438C9E361E7EBBE" modified="2018-10-10" version="1">MTPYNESCLFDPKWLTQTINFKNPSSSWVITQKIQEHETLFSADEYLSSGFYSESTCISTCQEIGSSNQAIMKIRMQVPNSPDDASSSASFIQPPEREICGRTLLEIKALETMTAAKCSCIPKYITSKHENRGSNGWVSGGFVDYIVMEKVEGVTVSERYVDGLQVEEQDELRKAFRLSYLECQDLGFVHLDQNLTNLIWDKRNMKCYIVDWEAWGGKAYEWSDNEYYRWGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRU7</accession>
    <name>A0A317VRU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_627453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463813.1">
        <property type="nucleotide sequence ID" value="XM_025617425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRU7"/>
    <dbReference type="STRING" id="1450535.A0A317VRU7"/>
    <dbReference type="GeneID" id="37119568"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="320" mass="36160" checksum="B25020F1FAC294F9" modified="2018-10-10" version="1">MASHAQPGKGPGSRLKPVADPLDLVGFVSKGDRKLLDHQVQKDYYNKIVNRYMEFCSNHFKDLEAAWMSLPRSASSDATSNPPAPFPSPTNKSTGPHSPSASTEVSSILLSLRKLREAVLATGSAIPISFSQQVHIFSIKVAIQARHPPSYFPSFRYILEELHTLSHPLPGTDLKDLISYWILDYACRQEDMVAAYQLRARARKRYGFQSSTIDRVLNALAHDNWVVFWQIRNGVDSRMRAVMNWAEDRVRRHALKAVGKAYLSADARWITEGCTGDRNWTWENLVEAENLGWAKEGDRIIIRKPKQKPQTSLPPIKENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VS78</accession>
    <name>A0A317VS78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_192791</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464370.1">
        <property type="nucleotide sequence ID" value="XM_025606044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VS78"/>
    <dbReference type="STRING" id="1450535.A0A317VS78"/>
    <dbReference type="GeneID" id="37108187"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000240">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000011">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="261"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY77183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="549" mass="60495" checksum="F5C16E5279B576D1" modified="2018-10-10" version="1">MSAPLTKVLHRMQELFTNIVAALEAMLLFPSIFRDPTRKRRKPFHGVYWGRRSLDTFADEVDYLFTAPLSVQNMIAMSDKIRAQFRSCLESSPVCMLPSYNHALPSGTETGTYLALDVGGSTLRVALVELRGQGDMRILHVSSSYIDNDVKLLEGTLFFDWMAEKIDSMLREVGANCGREAVPLSMGLSWSFPIEQTSISSGLVIHMGKGFHCSNGTVGQELGDLIVQSCRERNLNVQVDAIVNDSSATLLSRAYIEPKTRMSLILGTGTNVAIHFPVHEIGLTKFGTRPPDWFEYAKNVIVNSEMSMFGGGILPKTRWDEVLNRTHLRPDYQPLEYMITGRYLGEIIRLITVEAVESAKLFGGELPHSMRDAYSFDTSIVAALEADASPLLTSSAALLQKEHTFVVPPSVEDLRFLRRLCQTVSKRAAGYLATAIHSMWCLRNEVEFPTTATSAPPSLKETQAVTVVESEGNPLSLSIACDGSVINKYPGFRDRCQGYLNDLAKETNAVRPSLDAITEPRVRLDLAPESAILGAAVAVAVAVAEKKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSY2</accession>
    <name>A0A317VSY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_549354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464039.1">
        <property type="nucleotide sequence ID" value="XM_025613440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSY2"/>
    <dbReference type="GeneID" id="37115583"/>
    <dbReference type="OrthoDB" id="3546385at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="8"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="270" mass="31860" checksum="AFBEA36BA77C066C" modified="2018-10-10" version="1">MDTAAIGFPLFPCLPTELRLQIWEEALPKLRRPLYMYRLGCWGRGSVSETHIHYEFKHRRLRDLVFSTSLFFVNCETRYVVLRWMRKHGIQMMYDPETSSFRFRRSFNPQSDIILIPATEWACFIVDPWMLVQAERLGPRAVTVGVPGYTHIAIPMEICESKRFFLGDLFRRVYWSTIEKIFVVTNAQDMLEGDVIKAGQHWELDSFTGFPIFVWNSERRLFEPHHNVLYEGTWDYVLERLQEASGGMMNLSGWEEGHRLEVHSVSVIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTZ7</accession>
    <name>A0A317VTZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_473608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464320.1">
        <property type="nucleotide sequence ID" value="XM_025608482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTZ7"/>
    <dbReference type="STRING" id="1450535.A0A317VTZ7"/>
    <dbReference type="GeneID" id="37110625"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY76507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="653" mass="73043" checksum="D82A27F293987CB4" modified="2018-10-10" version="1" fragment="single">DILNRHVLQHNVPPDGAKRTPLACQTCRRRKTKCDSNHPCSTCADTGEPCVREPSSMQAFMPMTRSRRKGSPGNPANAPEEEEDPDGEGNEMISSTGGTPPMQPDWGASMSVGGVAVCQVSGPPNPTPMRSCPGPDNDAVSSSSRRMTSTAITTPSSSGSWQLNDAAASQAQFVTTQIRSSDFGHFHQAWPFLHVPTFAPEKQATLLTSALANLSMWMQNTYRHHLIPYTINQELTRALMPKIVSIMHRRVAPASTFNWAAQWTDMAISTFRQLGVLHDQWLPDDGRQSAEERWVLCEQMKRLVFAVLRIDAYLSIILDRPPTMRYQEIGVPLPVSEGLWRAETRVARTQLHWSEPAGRARSAFCTMMRDGLDTAGFVTGYLQMPHLSLEDNHFSICSFLSELWGVCKEAHEEHHRHYRSPERNHTVDQVKIWKVYIQEWRDHIEKTDRLEESFFAQSPGDSNHFLGLNLTLYHLVCLKLHANLRLLEQKRCCAHCQEIDVEDVISTWAQSPDARQAVYHAAQLKRIYEHETMLYSPNDQRLGNVLGPAGLLASAVVVCLYCAKATSIGSSAAATEDDAFKTPTIELTQSQLPETPEFAEWISQEGGGGRVTVDGLSLNAFSLPRFSSWYRERLASSPVYSSRLIAFLLTLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUM9</accession>
    <name>A0A317VUM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_185333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464588.1">
        <property type="nucleotide sequence ID" value="XM_025606003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUM9"/>
    <dbReference type="STRING" id="1450535.A0A317VUM9"/>
    <dbReference type="GeneID" id="37108146"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016290446" evidence="6">
        <location>
            <begin position="25"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY78076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="496" mass="55159" checksum="EDBC19C96FE44EBB" modified="2018-10-10" version="1">MSSLSRWPIIVILITVLMATLVAADICSKLKADGIQVEEPLTLDYNVDLWRYWSTACGDLRPTCIAAPSNALEMSQVVKELHHFETLFAVKSGGHMPNNGFASIQDGLLIATKNLDQVLYNSDDQTATIGPGLSWGNAQKELHGIGRTLVGARMAGVGVGGYMLGGGMSFLSSQYGWAANNVINFEVVLANGTVVNANKKANTDLFTSLKGGGNNFGIVTAYTLQTHPQDHKVWGGNYVFASDKGPQILEALRDFVEYCPDDKAAIILTAECAAFLDTWIMFLFYDGPKPPQGVFDNFTAIGPLDATKTWNRYYDLLKHNDFFILHGKRYAIATETAPLPDKSVGAEVLRTYYRHWHSVTKTVLDVPGMVGSLAFQPMPKAITSKAKARGGDLIDFPIDQDYIVIEFDFSYDLSRHDKEIDTAIRSLFNGFDNITSQYIDNGILPNVYRPLFMNDANHAQDYWGRLRTTEQARQTRRRYDPEGFFQKRTSGGWRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUW5</accession>
    <name>A0A317VUW5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_188837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464678.1">
        <property type="nucleotide sequence ID" value="XM_025606028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUW5"/>
    <dbReference type="GeneID" id="37108171"/>
    <dbReference type="OrthoDB" id="5308957at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clr5" evidence="2">
        <location>
            <begin position="7"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="359" mass="39719" checksum="9296E4652C2E9B24" modified="2018-10-10" version="1">MKNSIPSDVWERKKALIAKLYKDEEWPLKQVIKQIRSDDFNPSETQLRSRLKKWRVTKPSRQTRKKSDDSQQETTGDDSGQEDASPKDQASTISPKARPPLRSVASDLSVSEPEWYMANGLPTTMCLDGQHISNVWAPVMAQQSPLSPSHKQRDPSHASSMMVLPSSNSYDSPHTSPLMDSMLINSTSSMASPFPDHSYAVTTDCMQTPATTAGPIQWSIPQWYSMPLEAGSPFYTSAPLSPPIDPAMHLMSPHAQTPPPSSIGRQQMADLQEGTWKRAMSAPYVQDAAGGHPRLEQKGPQPRPLERKASLQPKPAGQPAMGLVSPPSFYPHGQHPMCAPMYQYPGSENLVHRPQSIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUZ4</accession>
    <name>A0A317VUZ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_537909</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464635.1">
        <property type="nucleotide sequence ID" value="XM_025612378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUZ4"/>
    <dbReference type="STRING" id="1450535.A0A317VUZ4"/>
    <dbReference type="GeneID" id="37114521"/>
    <dbReference type="OrthoDB" id="5422384at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373">
        <property type="entry name" value="FROUNT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13373:SF21">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7 9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="114"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY78123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1131" mass="122513" checksum="8FDE86C2F009265B" modified="2018-10-10" version="1">MSFKFSLESSPPSTPGHSRSLFSNLSETPAGDPPSASKSFTPQGHPSSSVFGSSQMSSGSLFTKSGNINPNDSIFGSSIASADFALPRGKKTTQTKSFAASQSLFSITNGSRFAESTSFGKSNRFADSQMDEDADQDAEGEEDVLPEEEVEETGDTMDMGISQKDPAPRFSFLDSQLGDSIAAPPATLGQRKSIYSNPTNAKRPKLDEQWANKSPLRKGKLSPKKDSAMPSIVRNFASRSRLAAVKESSEFIMSTEDEICRMYDEVKQSELNGADFETALSDACDRLVTVWKTSTNPNGLEQSTGAGIGPGDHASSVAKATFLASLLLQLHHPPRLAAKPSLLSPLGFPARNLLLAAPRTNSPTPLPKLLLDWLDANHMPLTAELQALREVEPNPSASSNFWEIINAAVLRGHLSEAAELLRSADFNYARSALEDGIPQSGYRGAQLQNIQRCVNRALQILESCPSVQHGDWDIRGSDWALYRKRVLAAVSDLEEFAEGNEQPSPEPPAAENRFQAVNFGLKATPAAPMFSFAQNARMAESKVPWTIYQNLRSLYRIILGDTSVVMNHAQDWIEATIGMTVWWDGEDDEEGSNNDFGASTNLLFSRLSKPQASPANARHAYLRRLDLAFSHATNAETDDAGFRINSLSSLEVGLASVFEGNVEGVLELLQTWSLCVASAVVEVAAIGGWLDPGAGAKSLPGLSEDDLMVLSYGQDGNAPSRRVHKNDVISAYASGLSQRATVECESGAREGWEVAIEVLSRLDDREKMQKSVAELLDKLPLNTSEQVDKVVLLCSELDLDIEGRKVSERFGDDTVAKSQDYGLALLCYARAHNRRKVKSIVDLLISYSLVQSRAYPESTDLDEQLEALIREPKHCLSAVAVTDEEAASILQYYFSGYATLRRFYETRDEAVSLQEGQRPRFKPLARRRAAAQALVAVIGSAADSIYGGLYDPDRDAVIQVDGLLTLLGEALPFIDQPTPLLSVSQQFTILSAIEDLQTVTPRVYAQCEECFRSTLIQYHSSKRAHTSDSFVLPPSPRAMLKKSVSALTASSTFSLIGSDMIESARTRSGSGSGSVGSSGVLVPRSDAEAATTARGWDWRAGLPEDAAGEDILRILRLGLAKGLSHGALGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWA5</accession>
    <name>A0A317VWA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_626797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464375.1">
        <property type="nucleotide sequence ID" value="XM_025617376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWA5"/>
    <dbReference type="GeneID" id="37119519"/>
    <dbReference type="OrthoDB" id="2446291at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY77188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="297" mass="32653" checksum="4C3EBC2DB217D011" modified="2018-10-10" version="1">MFTFTSKRQRDPEQDDFDGNATREKKKHRPLPLRASPTTLQFPSFQKSNRVVSRFGLSTPTPVESSDDDKDDNGVGESLYNCSTQPWCLPMPTTARLQQCPPTSATQQDPQHLPHTLSANMDIDNGKETHGLKTASITHCLVGHSHIISERPVAHSANDAVRAAQDSVAKGYHQSSTSSTQRGVLRDPYSIHDRVWWCGQRLPSPVSDDEDAMAISSKDSASDADMTYLSQPASPPPWDPGATADLQPPTGLADNLVLGCSPTSVLKKKVTFSMGYRADCEKCRHKVPGHYSHIMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZE7</accession>
    <name>A0A317VZE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_498710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464457.1">
        <property type="nucleotide sequence ID" value="XM_025609354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZE7"/>
    <dbReference type="STRING" id="1450535.A0A317VZE7"/>
    <dbReference type="GeneID" id="37111497"/>
    <dbReference type="OrthoDB" id="5332281at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="663"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY77270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1177" mass="128895" checksum="5727EB5910A102D8" modified="2018-10-10" version="1">MFANFMPKAKAFTRVAQKPPSSHVRTVSSHSDDSLAGGLNHEVRRQMWVPVMLHSMTFVAFAVLFIIFIIVIEVLYSVSNRKDGLSSSQEKYHYLWTYGPTAVLTIVAGFWGQVEYRTKQLAPWKSMSQEPKPGSQSLLLDYVSDWNVVVMFRALRQSVWVVPLAVLGTLLIKLVTVVSTGLFMLQSVYMEAVPTTLHTQASFNAAGYDGAKVDGTAAMVVAGAWWLDLSYPVGSTDKYAFQPFTSKSQLGSQAVVSGTVDMFSADLQCDVGTVTNWTQECTSQGCEDLQLNMTLSTPSCSKYPLSSFIRSTSCVGGYYADVFSATCADTAADEQLIFAAAHWSENLTEIQTLICSPTYNITQGSVSLLYGNQSVVSLHPSNSSTYRTIPDLRPAELGTGLVSTMAGAEDTLDTLTYVDDSTTEGRGYQYNFSDPNSTYPSGFYVVANLSSPHAMSDLLDASILERVSRPAFTAIAAQIARQYLLSSADADFKGTYSAHIQRVVVRELSARIMEAALAVLVVLTAMLWVWRPVRSTPRDPGTIAGLATILSRSPDVSHRLAGCRNAQDITAELADGKYHTRVTDYDGRTFSIEEQHATEGTRTRVSSGPMTWWQPMSVSLWWWAISIFLPLLIIAGLETAYQMSAQHDGLGTVDSSGYIRYTWVYLPALVMLIVRIFFDCIHFSAMLFQPYLELRRGGVTAPSSLMENHLSEVTIYSFITAIARQQWAICATAFTVLLAPVLTVAVSGLYSTQDVVNTSPASIARTDTFNYTITPHSSTDSDPGLGLTGALVVAVNMSYPAWTYDELVIPTLSEDSLTDKHGKVQDQSYLNSTTDDPTVLELSLPALRASLNCTALPSDVIYNVTLPDDFFPAWSIEMSLGENCQDGDGTVSMSVETDYPNQTQAVFGSFQYLSGFAFGECPSLLGFYGVFNGNSTSNLRGFTCNPQIDQVNATGTFTLPGLEIQSVTTDASSSQLFSTNITSNLYFTDFLPEATNQYNQAFDNVFSAMLNDEKTLSISDLTDMSHYDTVVNATQHLYRVLMAQSLNGNSRIPSTTNSTRYTGTIVNPNRVRLVQSAISTRIIEGCLLAMVISTVIAYYFMHTKEVIPVNPCSIAGAATLLAGSDMVKSDVLPPGSEWCSDKELLRRGYFNGLVFGLGWWDGPRFGIDIGKPEPYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W046</accession>
    <name>A0A317W046_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_603605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464857.1">
        <property type="nucleotide sequence ID" value="XM_025616442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W046"/>
    <dbReference type="GeneID" id="37118585"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="60861" checksum="7F13B638BC04E52D" modified="2018-10-10" version="1">MRQRSTPGALGAIRRDPQIAQASAAPYSYGGSSGYSSGQWNGGYSGSYGQQSGATDMSAAGSAGTAGTAGTAGTAGTGSTWGTGSTAASGAYEASANTASTWSETGTTPQESPAAWSNQWAAPSPSPWAASDTWETSAIPTPTTTWESTSTPVSSISTTTTAASSTTTAASAAATGAPATGTPTSTKVGIGLGISLAVIAILGLFLWSLHSKKRAVQRAIAEHHRKSEKSNPSPGPRRPSSVKRCASSFYNSSVSAMGAVPEAARSVSSRLPSMPVISKPDYAPIKDFTNKVYANGRNTLRTATGIVKATWRRSRMHVPRPASENMHDPNGTLRDGFRQIHQSYLELPRPNEKIHPALRGLHSSTETLVGADMGRLKEVSVSNTPPKVDTGRIPEAKVATLDTVSRGTSTNESTPAVSRSPTIEIPTIELPTSPGSPPISLARVYSVDMAFRPVSPEHIELKEGQTAILHLVYDDGWALVTLLETNKEGLVPRACFSAQPVRNQAQYLGNNISISTESVPRSTGSATPTPSETASDGGLGRFYSQCASPDLGPMEPEMPPNAKLKSLPSLASLFKSAPSFKSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1W1</accession>
    <name>A0A317W1W1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="5 15">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_162551</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Endo-1,5-alpha-L-arabinanase involved in degradation of pectin. Its preferred substrate is linear 1,5-alpha-L-arabinan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="5 15"/>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465322.1">
        <property type="nucleotide sequence ID" value="XM_025605878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1W1"/>
    <dbReference type="STRING" id="1450535.A0A317W1W1"/>
    <dbReference type="GeneID" id="37108021"/>
    <dbReference type="OrthoDB" id="195678at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18831">
        <property type="entry name" value="GH43_AnAbnA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF7">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016252025" description="Arabinan endo-1,5-alpha-L-arabinosidase" evidence="18">
        <location>
            <begin position="16"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="17">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY80463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="318" mass="33992" checksum="CEAD11D201CE9772" modified="2018-10-10" version="1">MFSFVLLLCVALANAYSDPGACSGSCWAHDPNVIQRKSDGTFFRFSTGLGIHISSASSITGPWTDLGVALADGSEVTVGNASNLWAPDVHYVDGTYYMYYASSTLGSQSSTIGVASSTTLEVGSWTDHGEIGVTSSSSTPYNAIDPNWITIGSTPYLQFGSYWDGIYQVEMTDSLTSSGSTPTNLAYNASGNHAIEAAFMFERGGYYYLTFSSGQAQNYISSPPAQGDEYRIVVCRSQTGTGDFVDQNGVACTNSGGTTVLASHDYVFGPGGQGVLNDTTYGLVVYYHYANKNIGLTVDDYQFGWNQLTWNDGWPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2D3</accession>
    <name>A0A317W2D3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-T/Histone H4 histone fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_497278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465004.1">
        <property type="nucleotide sequence ID" value="XM_025609311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2D3"/>
    <dbReference type="STRING" id="1450535.A0A317W2D3"/>
    <dbReference type="GeneID" id="37111454"/>
    <dbReference type="OrthoDB" id="10071681at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22920">
        <property type="entry name" value="HFD_CENP-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000105">
        <property type="entry name" value="Inner kinetochore subunit cnp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF5">
        <property type="entry name" value="CENP-T_HISTONE H4 HISTONE FOLD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="6">
        <location>
            <begin position="362"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY79432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="470" mass="51791" checksum="6F1243A2EC01B739" modified="2018-10-10" version="1">MATTPNPRRRSPRVSDGSEAFTPVGDTTLTGLQRLPGHTRYPLTPSRLAANTPSANRRTPRNRGAGAPSTPYRVQAMQRRAANTPGRDRRRSGRVQRETTFDILQNLGKALAPTTQPIRSSPQDKPEPEPEPEPERDEIEELDNEPEIERPRLSLPLEEVDEVDEEPEMRPPRLSLAFEEEDLTHTSIEYPRRATSEHDRGRLSMMSAGGPRMSEIGAATRIESESEDGDDTGIVGDENEGEGEDTVISQGDFDRGGETEDLGRFNFDFNFPTPPPPGEDLDQDGPIHDDEGFELPVDMPLDTEAGVDDASVSIAGNDFGMESPMPEPMVLSESQSPGIAGGGLRDEDRFIPGTKQEKLSRHGIPVPNLPVGVVKKLATRFARARHGSKAKISKETLAAIEQASAWYFEQASEDLTAYSKHAGRKTIDDSDVATLMRRQRHVNSATTIFSLAQKHLPKELLQDMRLAMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2Z5</accession>
    <name>A0A317W2Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phospholipase D/nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_537116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465568.1">
        <property type="nucleotide sequence ID" value="XM_025612192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2Z5"/>
    <dbReference type="STRING" id="1450535.A0A317W2Z5"/>
    <dbReference type="GeneID" id="37114335"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="88"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="632"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="3">
        <location>
            <position position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY80966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="699" mass="77384" checksum="A70A7C2117680B52" modified="2018-10-10" version="1">MSSDDLLDADLRAAISASLAEAGHQSEQSSRPRSIQFVDLTADSDSDDDDIIPVFPKSRSVIGSDTEEEDYEDDDEALRAAIALSIQEAGGQISDINSSGGSESTSSEASQSTDSEDGESQDTDSPSVTEVEARPSSQEPARPMGILGLDRRQMEEERLARLAKRKAQDTTLADQRPTKQSRTNSASKTSVSEPKRATRYVTTSPSQAGSSSSTPSSSPSIQFPEGVVKKTWAFGSLRQGDDIKIGEVFQKSDLQLAVLSSYMWEMEWLFSKMDIGRTRFILMMQAEDDAKKRQYESETAYMPNLRLCFPPMDGQVNCMHSKLMLLFHPGYLRIVIPTANLVPFDWGEEKGVMENTVFLIDLPEKRNTLFDGQPKTSFYEELVYFLEASTLHDNIVAKLDGFDFSKTSKFAFVHSIGGTHTRSRWKRTGYCGLGSAIEKLGLRTSSPINVDFVSSSLGAITDELLRTIYLASQGDNGLTDFTLRTAKKFPAPRRDDSSVTIKKETAAEWKDRFRIYFPSQATVNSSKGGSGYAGTVCFQSKWFESVKFPRHVLRDCKSQREGLLMHNKILYVRPDDPISLSDTTQCRAWAYVGSANMSESAWGRLVQDRATKTLKINCRNWECGVLVPIIEDKKSGPSPQNEHKGSETTKGKGKAPASSALSDDGANLVSVFGDTVPVPMQVPGERYQNGQKPWFFMEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W3X3</accession>
    <name>A0A317W3X3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_587758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465160.1">
        <property type="nucleotide sequence ID" value="XM_025615850.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W3X3"/>
    <dbReference type="GeneID" id="37117993"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000024">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000104">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000158">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF74">
        <property type="entry name" value="HISTIDINE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="10">
        <location>
            <begin position="959"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="1217"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1764"/>
            <end position="1886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="333"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="833"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1438"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1509"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="333"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="838"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="858"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1455"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1513"/>
            <end position="1530"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY80301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1909" mass="211119" checksum="58ADB3430847851D" modified="2018-10-10" version="1">MRTPPLPSPAEAPSPVAAPHSHRRGSSHSTGFLPVHTAGFSIDEDAIAENNTWNANSHSSPIPLEQTTNACHISTPAKKDNPEVGKYPEDQGRSLQTLKELRRQMEELLVYQQMQQSQNQSSSASREAPSSQTEPVSSNSPGSTRKRPLNVSFQKVTSSTGAMPSASFSDSTGSGGTIRAMDSTPENLTGQTPSYPFPRMQTQPTAKPSQNSTLNRSSFKLTLPSEKLKIHMAPSQVGEEQQLTGLDTPHLQRFFLPPQSKSVIEDPNYPSPNLYDLTLQLNADPGLDAWWGNVIHILQAHYGAERVSLAVPGDATDLENVPWGQKAVFDRNIEPESQARHLHDETTTPRDNNSKEKEDLEKKKMKKESFIAEALANGSSASKSPKRPPLLSRHSFAGFGKERKHPNIQDSDAQHLRSLKTPSKPEVKRTSTLPENPTAAETEPVPTQDTPRQAVFPIPRPLEVEADPLIKRTGVVKLFGRTEPVVLTREYSQGLASDQTPCETPEDKIQVTPTAEPCNNQPPYDVRSRSTSNPPALGLQAQRSMEFFDEYEQIPPSPWSQSPAPSPAPRAHAEQNPFFVSHAVDEEAFAKHPPPHDYSNLQPLEAIGVDMAKSVVHIPLLHAGRSKQTSPSTLRFPVAVISILSSIMPYPSNLRKSLAYLMPHLTTSFCLAQQYSQLERQVTSRLEVPRYGHLLGLGGTFSDESSELELVAGLSGHVNYTIADDGSLSARASLSSPEERSSSAKLSPSISGLGTPGFDLSNIGAGTTINPNESPGLAARIGNDGVDSYFNVQSKQFREAIAQRMILSKAKQSVAASNPTSPGKLLGKVPTEEELAPQAQSPATISPSQEIKAPPVISPTQTSSRHPSTNSFYAQLQRELPRPFTDTVAQLMLNSVPLHLFLAKPQSGEVIWTNSKFDAFRRSQPQEQKLRDPWQNIHSSEREHVSQEWANALRTGSQFTERVRVKRFNDESAYRWFIFRANPLLSSTGEVLYWIGSFLDIHEQHIAELKAAQEREKFATDAKYRAFSNSIPQIVFEATEYRGLIFVNEQWHLYTGQKLEDALNFGFAKHVHHDDLEKCGLLSVYLHEAQKNGAGLDSGEIATETTTAKTSQDKHLGHGVTPALEELVKRGVASVQRDENGRVFYSTELRLRSKGGDFRWHLVRLVCVETSSFGSGEASWYGTCTDINDRKNLERELNKAMQQLNNQMESKTKFFSNMSHEIRTPLNGILGTIPFILDTQLDTDQRRMLDTIQNSSTNLRELVDNILDVSRVEAGKMSLVNSWFHVRSVIEDVIDTVSSRAIDKGLEINYLMDVDVPPMVIGDRFRIRQVLINLVGNAVKFTAQGEIHICCSIYHDASAHIKKSELLLNFDVVDTGKGFSARDAERLMQRFSQLGQNGSQQHAGSGLGLFLSKQLVEMHGGKLTPSSKEGQGAKFSFHVKVDAPPPPTPDETRTIRQSQSASETLGAQPKLSSLQKLLFSKDPLNNKGPDQFELSSALESSLAKAHAHADPSSRFSTNNLSERSSLSSALPTPDLSTVDPLAKIDSSAPGEGDTVTPVGGDNPRPATESSSQLQEPPASIKSTALDGVTDAKQLPSSFSILILCPMDNTRKAIKQHIEQVVPLEVPFSITSTPDVEDWRDHVSDESVSKLTHLVLNLPSVDDVLDVIQYVSESDPATAPTLVIISDLYQKRQVNSKIKELAASGRRVYTVPKPVKPSAFSAIFDPDNRRDLSKDRNQDMAREINNNFKTMSKMVKEVIGNKGYRILLVEDDETNRMVMLKYLDKIKVMAETATNGQECTEMVFSKEPGYYSLIICDIQMPVKNGYDTCREIRGWELKNHYPQIPIMALSANAMTDQIEDAARAGFNDYVTKPIKHNELGKMMMGLLDPNRPLLLLRDRLRADSEDHHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5F3</accession>
    <name>A0A317W5F3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor Rba50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_537387</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RPAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464942.1">
        <property type="nucleotide sequence ID" value="XM_025612255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5F3"/>
    <dbReference type="STRING" id="1450535.A0A317W5F3"/>
    <dbReference type="GeneID" id="37114398"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="4">
        <location>
            <begin position="99"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="290"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY79370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="461" mass="48506" checksum="E2497A0C0B3F32D0" modified="2018-10-10" version="1">MAFRGERFVLDLDSDDDTTPEAPYNAPPGSSSISIPGMIGEIRERSPAAAPAPPTPKPSTTGFPAHRRRAKPSAFKQRRAPAAPASAPSPGPTDEKTVIAEENERQLASMSDAQIQQEREELMESMDSSLLERFLRRARIDADDTIATSKPAASSSAEQPAEAEPTPAPSPPATLISSPSSSSKPTPANEPSPDDVPPAQTPSDLHAAAELPPSGSVHFPAPPSQASPMPNLDPSSPSFLSDLQTHYFPNISHDPAALSWLQPPSADPEDPDSTSAYHPASNAEAVHPANLRFSLLGTVLSPATSLSLPTTLGLHHHGKDPHAAGYTIPELAILSRSTFPAQRCIAWQVLGRILFRLGKGQFGERGSPLVEGLWSVVEREGVVAGMLAEADGVTAGSRGEKGSTAEETKESSQDKESAGTGASGRRQHASATAWAVEGVWLWQMGGAGDRGVLKEGTIRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8R8</accession>
    <name>A0A317W8R8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_147028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465710.1">
        <property type="nucleotide sequence ID" value="XM_025605770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8R8"/>
    <dbReference type="STRING" id="1450535.A0A317W8R8"/>
    <dbReference type="GeneID" id="37107913"/>
    <dbReference type="OrthoDB" id="2898509at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052228">
        <property type="entry name" value="Sec_Metab_Biosynth_Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534:SF2">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47534">
        <property type="entry name" value="YALI0E05731P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="333" mass="36693" checksum="5D12B802EFE74374" modified="2018-10-10" version="1">MVSLKAVQASNAGLRALPNITALFVGGTSGIGQSTLRQLARHADSPTAYIVGRNQARASPFLSELHELSPKGRFHFIEADVSLARNVDVACQQILNKEKHLNFLFMTPGGISLGGRNETIEGIDYLFALRYYSRIRFIQNLLPLLESSSGPSRVVSIYGGGFEFSINTSDLDLKHNFSLLNAYKHSITMTSTSMEHLSNTHPKVSFVHAYPGLVGTNIYNNSFPWPISSFYNYAMWPFFQVNLQESGERHLFHLSSARYPAKEGTTNQGVPVDSEAGGVATGITGHVGSGAYLLNWKGDVSSSNKILAQYREQGVPEQVWKHTEELLAEAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8T6</accession>
    <name>A0A317W8T6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_520494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465785.1">
        <property type="nucleotide sequence ID" value="XM_025610112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8T6"/>
    <dbReference type="GeneID" id="37112255"/>
    <dbReference type="OrthoDB" id="3546385at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="297" mass="34695" checksum="E28DF4CE72C67E67" modified="2018-10-10" version="1">MSSYSFSSSVFPKIPTPNHAQPTPAQFPKFPLLPTELRLLIWHFSLPSPVHHGLYIYQKGCWETHLDPENAPGPDPHFNLIFNDSSLSTMRIDIPPFLVNHEAHPIAHHWLQRHRGPIRFQQTPTGFHFMRPFQPNSDALYVPKNRYLEFICEPVDVAWAPGLEYATNETFPPTFPRIAFPKAVLESQKNAIKGIFELYHYENIREVLIVDEMEEEEDDLMVLARVQRPWEWVRARGEELLVWDHQGKRYQRQGGWDWHPEADEFMGLVEKASVNIDAGMSWTGDRFEVRLVHAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9V1</accession>
    <name>A0A317W9V1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_470518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465452.1">
        <property type="nucleotide sequence ID" value="XM_025608338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9V1"/>
    <dbReference type="STRING" id="1450535.A0A317W9V1"/>
    <dbReference type="GeneID" id="37110481"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY80850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="498" mass="56381" checksum="08C71DB27689E1D8" modified="2018-10-10" version="1">MLRSIGTRSVKAPMVGHRSVLEPAWLVGYRFTTQGRSMLRAGYKNFRDKIFKVRCNGLEVVLLPNRYIDELRNVPEEKVSPPKALFTKGLGHYVGMNIIMESRLHVHIVQQRLTPNLVSIMPQLQQELEFALEAELPDCRTDEWVSVNVQDLLARLVGRLSARVLAGPELCRKEEWLSASVKHSGHAFATSMTLRMFPGWLRPIVAPMIPFYWRARSDLATAKRLVGALVERRRATEAQQGTAYEKPNDLLQWMMDEATGTDAFPHKLAHRLLFVSDASVLTTGILTTHFLLDLCAHPQYLKPLLAEITHVLREGGNFQRTMVHKMVHLDSFLKESQRMNTTFLMTFDRVLNTPITLSDGIKLPKDTHVAMPTDAMLHDPTYLPGGGDPDSFDPFRYARLRQKPENAHRYQLAMTDSTSLPFGHGKHACPGRFFASSEAKLLLCNLLLRFEIRLPDGQTRPDNLLVAENLVPDPAARLLFRKRAVGDELSRNLRTLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBD8</accession>
    <name>A0A317WBD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_119358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465916.1">
        <property type="nucleotide sequence ID" value="XM_025605566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBD8"/>
    <dbReference type="GeneID" id="37107709"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="121" mass="13384" checksum="4F34E2822736F14B" modified="2018-10-10" version="1">MFILGCGNTLFTFSSFRPGQCSAFVFLIKLCFSVLPIHSLSCALCPSGPPQFALKDRPGEMDGYHWSMRVSLPPPAQKTSSFVRMPALPSQARTGPRQWLERGQLSSTDNSVDSLAYFHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBR4</accession>
    <name>A0A317WBR4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative MYND domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_115265</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466261.1">
        <property type="nucleotide sequence ID" value="XM_025605530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBR4"/>
    <dbReference type="STRING" id="1450535.A0A317WBR4"/>
    <dbReference type="GeneID" id="37107673"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY83793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="246" mass="28158" checksum="1E8063299BFCA7BB" modified="2018-10-10" version="1">MADTDAPATCTVCFKSGSDAMPLKRCAKCQTQRYCSRECQKADWTKHKKTCGESADEKLPNPFVTQKAFPRPQTLEVHIQKPFHELHNKTWLHNRHENDVYQLLIDVYRMRMEDRYVFFGDADLDCIYGGAPHSGKEFRRFLRLTEGHPGLLPEWWSSENAMECMAFGLRPPNGWSSLAHPVEKADVIDHHKDPSFPMQLRMFGEQVWGMGPAGLPGAVMMQQMMQVERGEGVMILENHASAMRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBW9</accession>
    <name>A0A317WBW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_576451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466046.1">
        <property type="nucleotide sequence ID" value="XM_025615138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBW9"/>
    <dbReference type="STRING" id="1450535.A0A317WBW9"/>
    <dbReference type="GeneID" id="37117281"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21456">
        <property type="entry name" value="DLC-like_SpDlc1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15132" checksum="99181C52A1F87E28" modified="2018-10-10" version="1">MAVDVATPSSPVPIPELTKIATEACDTSLKEVTEYEHTKVGEWNSQIINTILKSLITATAPSSPSTAPPYRFTVNSTIVQQGLIDKSAAADGAASNTGKRGMHSASGAFWDVNRDGMWTFKYPGAEERGLDVVVSVTWFALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD30</accession>
    <name>A0A317WD30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored serine-threonine rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_547743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466052.1">
        <property type="nucleotide sequence ID" value="XM_025613344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD30"/>
    <dbReference type="STRING" id="1450535.A0A317WD30"/>
    <dbReference type="GeneID" id="37115487"/>
    <dbReference type="OrthoDB" id="2507140at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016304864" description="GPI anchored serine-threonine rich protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14604" checksum="44C8DE843A08090E" modified="2018-10-10" version="1">MYILHLLHLLLTITLATVSIATPTAAAAAAADTAPAPTSTSDSSSPYVQCAKNILEACLAQMKPEMDNCSQNDWSCLCTQSKNMLTCYNDCPSDPNHVGADQQKMEYCNAAEANSLYSTTTSSMHLDGVDEDGGCKCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDT9</accession>
    <name>A0A317WDT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_536144</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466499.1">
        <property type="nucleotide sequence ID" value="XM_025611950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDT9"/>
    <dbReference type="STRING" id="1450535.A0A317WDT9"/>
    <dbReference type="GeneID" id="37114093"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="122"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="333"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY84574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="521" mass="57056" checksum="5407867DB5143FAB" modified="2018-10-10" version="1">MAPSLSPEPVVDEPYESSDSEAEQTDLQSRAPKRRRLSESSNDSYVAPAPLPTLSRIKKKEAKEDKPATSDKDEPVLIKDALEIGLQDAQSSFTSLKVAPWLIGALTTMAVRKPTAIQKACIPEILNGRDCIGGSRTGSGKTIAFAVPMLQKWAEDPFGIFGLVLTPTRELALQIYEQIKAISAPQSLKPLLITGGTDMRAQALGLSQRPHIVIATPGRLADHINTSGEDTIRGLKRVRMVVLDEADRLLAPGPGSMLPDVETCLSALPPSSERQTLLFTATLTPEVRALKSMPRSADKHPIFVTEISTENKSSIPPTLKQTYLKVPMTHREAFLHVLLSTEGNATKPAIIFCNHTKTADLLERMLRRLSHRVTSLHSLLPQSERNSNLARFRASAARLLVATDVASRGLDIPSVALVVNFDVPRNPDDYVHRVGRTARAGRHGEAVTLVGQRDVSLVLAIEERVGRQMEEWTEEGVSIEGRIVRTGVLKEVGEAKREAAGEIEEGRDVLGRKRNKLKKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDZ6</accession>
    <name>A0A317WDZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NOT2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_536283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466611.1">
        <property type="nucleotide sequence ID" value="XM_025611979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDZ6"/>
    <dbReference type="STRING" id="1450535.A0A317WDZ6"/>
    <dbReference type="GeneID" id="37114122"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1020:FF:000007">
        <property type="entry name" value="Putative not2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="310"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="186"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY84686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="452" mass="49027" checksum="2AA2132A680CF802" modified="2018-10-10" version="1">MGTFAQSLSGSQPATPLDLSDFPSLSGAPPQSQTQNPSHLVWANASQRAMQQTPVQRPQHATSQAPSRAPQTQTHHPQQPSQPSHDDVFPSGAQFANRLDDFRNGGQGISGQLGAGGQPQTGNIEEFPPLGRNVPTDLGQDRRGSLMQSAGLGNYTGGLPFTGVSQAQSAQARSMVAASVNGQERIMSPANAGSGGIETSRSPVNQGSSRAPGQEKEELNNSVISNPSVYSEQHLMRPPGFPTTGKEASGAAPSTDQLPFAEMSELDKFGLAGLLRMIHSDNADVSSLAVGQDLMTLGLDLNQPEPLHTSFASPFVASMSGVPLEQDFALPSCYSVANVQPLQSRIPSFSDETLFYIFYSMPRDILQEVVAEELMGRKWRYHKIERCWLTRDETYPGPVDVERGVSERGVYLLWDPASWKKVRREFILRYEDLDNRMDPNRGLARVGFPHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEN1</accession>
    <name>A0A317WEN1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_536376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466150.1">
        <property type="nucleotide sequence ID" value="XM_025612007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEN1"/>
    <dbReference type="STRING" id="1450535.A0A317WEN1"/>
    <dbReference type="GeneID" id="37114150"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="247" mass="26727" checksum="4C37D3B1D0C24D3E" modified="2018-10-10" version="1">MSFRPMLQQRAVAPIAATLLAGGITLYPRRTAFAEEPQDAKKPIYDDFPTEIPAAPKPVLRSAPTPVSAPLSSSSSPTPTDILTAQVRQARLFLYQNSLAVETCFNNFLSRALHIENAFTNTVASLAPSPESGERLLPGGVYVVVAAMAGSIVARNRGVLLRTASPLALGTVAAWTLLPVTMRNVSDLVWEYEKRVPAIADTHLQVRGQAEHLWYTGVAHSGMARAMMEEKIGDARKKLEEVVSKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WF66</accession>
    <name>A0A317WF66_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_557697</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466340.1">
        <property type="nucleotide sequence ID" value="XM_025613946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WF66"/>
    <dbReference type="STRING" id="1450535.A0A317WF66"/>
    <dbReference type="GeneID" id="37116089"/>
    <dbReference type="OrthoDB" id="5424793at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="8">
        <location>
            <begin position="65"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="749"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY83872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="847" mass="94389" checksum="86DE85516CB12601" modified="2018-10-10" version="1">MSTPFDLRNPGRPIHVGVVLLNTVTEHLDIAPVGFFHNISKDFIKTLPPFAMTDEVRSQALDFVTHWVTEDGKTPGVLSGNLKVIPTDSFTTCSPLDIILIGAGQTGYQATETEKAFLRKCYSECSAFLSVCGASDALLATGILEGKTATGPRSFLPLFRQIAPGTNWVEKRWVRDEKIWTTGTLLNGLDMIAAFGTEMWGGEGSLVEHMLTLAIHVGPARSGTPVEGKHEVPRIICFVYHAELRRCAKLGYMCTVTGSPPLTTARSEKSPKTRDVGATPHPPSSSDDLVSNLFQDKPREKDQVMQLRELHRGLLPGHTTDDGNPPTPIHTPPSISETVDCEPKSIKINLSMQEAEELLHQFNQRRTYFPFISIPKDTTASSMATSQPFLLLAILTISLTRKPLLQKRLDERFRRVLSERIIFYGEKSMDYVQGLLVYMAWRPLHIRPLSNQGSQFMQILVTMISDLKLTERMHDEGARDVCLGCYSLSSLVSVGFRRRGDDTAYSYLKAAIESNSTPNQPYNEQLQLAKLQILFEETIRSQTECISLKCPNTKDQRLKQKMESLRLELQIFQRVHTLNTSTSTPTSKKLYTNTPTVPLHLSTLSLKVHIALLPFRILNPKSPLRPDLDQATSCATAIRSFFEYFLSIPQEEYITFSIREWCQLILTISASSYICFLPLAPGSGLTSPEWIDFQVKTRSNMLIYLESLSHRMCSLSVTKRGDTPDLFFMFKSVLDIVLPTYAPVHGGSSAMREEESLREGSPEMSVPTRSATSTRCPMMNGSIRQSEFWEAMEQSDLYFEGLGNGNGGNGGSGEDMCSLGVPGVGSLFDDCGDWPSIFSEWVNICNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFU1</accession>
    <name>A0A317WFU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Snare-dependent exocytosis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_536141</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat L(2)GL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466496.1">
        <property type="nucleotide sequence ID" value="XM_025611948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFU1"/>
    <dbReference type="STRING" id="1450535.A0A317WFU1"/>
    <dbReference type="GeneID" id="37114091"/>
    <dbReference type="OrthoDB" id="19944at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045159">
        <property type="term" value="F:myosin II binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000848">
        <property type="entry name" value="SNARE-dependent exocytosis protein (Sro7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013905">
        <property type="entry name" value="Lgl_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241">
        <property type="entry name" value="LETHAL 2 GIANT LARVAE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10241:SF25">
        <property type="entry name" value="TOMOSYN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08596">
        <property type="entry name" value="Lgl_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Lethal giant larvae (Lgl)-like C-terminal" evidence="7">
        <location>
            <begin position="515"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="898"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="901"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="926"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY84571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="997" mass="108327" checksum="977ECC02989307EC" modified="2018-10-10" version="1">MAHFLRGKQAGIQKDFSENLSPHLFALDDFARCGINSRISAIAYDPVQSLLAVGTSDTQFGHGQIYVFGQRRVSVVFSLPRKASAKFIQFCADKLVSVDSKSEISIFSLATRQTLVSYAPPSHASALLTDPSLDYAFIGLQNGDIIAYDLDRETLTPFRVPNLWAQRNPRARLCPVLSLSFSPRDIGKILVGYPEGAVTFSFKQNVAQKYFEYEVPPGALGGNGDVPSPDLRKPRLTRALWHPNGIFVLTVHDDNSLVFWDSKDGRKIMARSIQTPNIDQPGVAPERPPSAGTAGLKDPITQIAWCVKDNGDDSGLLIAGGRPKAEANKGLTFIDLGPSPNYQTSSWAIISKHFETPKRSAFLPTPPGAEVVDFCLIPRSTPYYSGGHDPIALIALLSSGEVITMSFPSGHPITPTNMIHPHLNFVHPFVNKATLTPVDRAAWLGLKEKRSQGPKFLLGGAEAKKALKRFEDRNVLTTSHADGTLRIWDVGNDDEIENGDVIQVDLARAVGRVGNIEVTEMSLGGSTGELSVGLKTGELVVFRWGSNQNFGREEPPGANEGPGSLTKITHRVDPGLKQGILPLTLLNMQQGPVTALKHSQVGFVAVGFEGGSLAIIDLRGPAVIHTAHFAELLKVNKRSSIFNKRSSESPAPEWPTAIEFGVLTLEGEDFSSICCFVGTNRGNLATFKILPAENGRYMATFVGTSLLDDKVINIVPVNADDGGLALATPNAVGGLRNGTRVNGVVIAVTVSGCRIFKPATSKGAHRSWDDYLCDSAAVVKTEARGYSIVGLFGDGHTRAFSIPGLKEIGSSPINQIADMRRLSDATISSNGTVLVWTSPSEVGLFSVWGAGHGLRPSEDQLYNPQAVIPPRPTITNIQWISGTQYISPADMDILIGGPDRPPSKRMQEQMRMDEEERRKAFREGRTPTNQSSSSNQEGYWSYMQRQMTERTEKLNFAGDNMERLEESSSNFARDVNKFVQNQKKKAVLGVLGSKFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH10</accession>
    <name>A0A317WH10_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YggU family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_566503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466783.1">
        <property type="nucleotide sequence ID" value="XM_025614559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH10"/>
    <dbReference type="STRING" id="1450535.A0A317WH10"/>
    <dbReference type="GeneID" id="37116702"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420:SF7">
        <property type="entry name" value="UPF0235 PROTEIN C15ORF40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY85766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14455" checksum="883E5EF9E87A13D5" modified="2018-10-10" version="1">MSNPFPLLRLIQTVTTKSRNNASLHPKRYSLQVSCHVRPNASSNREGIYSIGTDRVNVCVAAVPRKGEANAAVSRVLAQVFQVPKSNVEVIRGLKSREKTLAITDLNIGLQSEDEFLLQARGKLEAAIMQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHG4</accession>
    <name>A0A317WHG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466903.1">
        <property type="nucleotide sequence ID" value="XM_025611919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHG4"/>
    <dbReference type="STRING" id="1450535.A0A317WHG4"/>
    <dbReference type="GeneID" id="37114062"/>
    <dbReference type="OrthoDB" id="5419927at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40619:SF3">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY85886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="638" mass="72647" checksum="2B33CE8C40FD9AA8" modified="2018-10-10" version="1">MTTSMGNSNPLEYTASAVAFISSEGPDIHQGLGGYSQYSFQQDRFMPVNCHRSLEGLLQQYLPLNLGLQLPKNANELEQLSERLAGAEDRYNGEKNGFWHSIWYNLGEGEEVISNWIGLIPNEYGLAIVKTGLAVVFKLAERSAERRQKILNTFVAIRNALAKADPKRRNFRAHKDVAACAERLTQTITQSIEDMIKLTSAKPSWLKRLGNVPKPKQKTPQNPDYILERLAKSTREFEDVVNLARDNTIEATGYMAQSITSALPVMDDNIRGTYNRLQTMDRKQDVRDEESKMERQNLYTIIEEHHATLLGMAREQHENQLLARTTMVHLLRETKRLEAENKLLRRQQRFTPNFGGIIDEIQLIEILTLAPSFADGESSDSTYMLRQPNADLQLALTYKGKLNPESLRKVQTAVVTDTRVLEWLQCAESDLIMVDAKAINPGMTKISAISVFSATFITSMITARPEDVVVHYFCGQHFRPKDTWHGPNGLVRFIAMQLLMKLMGMKQVNLSFIRRETYVRKLEECDTWTLCHLLHRIVAQFPHEMTVCVVIDSISRIDTSRTSDELGVVMDHLHRIVTDPSLRPTVKVLLTSQMNTSRTLLQSVVFQDDPSRIVRLMPNKISRPLADMSGRVVRNMMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKC8</accession>
    <name>A0A317WKC8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lysophospholipase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_625173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466575.1">
        <property type="nucleotide sequence ID" value="XM_025617260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKC8"/>
    <dbReference type="STRING" id="1450535.A0A317WKC8"/>
    <dbReference type="GeneID" id="37119403"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF85">
        <property type="entry name" value="A, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016425663" evidence="2">
        <location>
            <begin position="19"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY84650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="341" mass="38403" checksum="875EBD6BC6E7868F" modified="2018-10-10" version="1">MFVTWRFLALAAIPMISAHPSGTLQKRVFKWGSTKYLIAFGDSYTYVQGTHGLQNYSFIGDLQNFEYSPQTLLTNKIVQNQAATAEGGPNWVEYLTGCGLEEGVTSPFDCGQQLWDFAFAGADISVEYTPLHHNFTVSLVNQVKQFNDYGQPVLKQTVDQSHALVAIWIGINDIGDSSKYDVDFPTFYNELMDTLFSSVQTIYSLGYRSYLFMNLPPLDRRPGNLGSADPSPNATQITWYNDALAQHADAFHGRYSDTNVMLFDAHSELSYILDHPSQYGIVNTTNFCAGYDQPDIEWNYEAYGCPTPLNTYFWYNSGHMTSHIHKILASAVLKKLKEWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKE1</accession>
    <name>A0A317WKE1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Extracellular mutant protein 11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_109666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466585.1">
        <property type="nucleotide sequence ID" value="XM_025605495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKE1"/>
    <dbReference type="STRING" id="1450535.A0A317WKE1"/>
    <dbReference type="GeneID" id="37107638"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029178">
        <property type="entry name" value="Ecm11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15463">
        <property type="entry name" value="ECM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Extracellular mutant protein 11 C-terminal" evidence="2">
        <location>
            <begin position="373"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="395"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY84660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="519" mass="57854" checksum="6041B29F428E7C10" modified="2018-10-10" version="1">MGVGDYVHAKEAGQPRPRTTDVPTQSRQTLAAQARVEVPPTNLVAPVPLPVNKSIPLEHYGAASFTEQMPQAPAENAVHRDMFDTDVEGIDESTIAATSVIGAEDVPIQYQLRPATVPQYQAAPVEERPLHPSRLPRRAYDGKWYENLGDNAMKSAGFDSEEADDASQLTSMAGDDERSDTTEDGNYARRYRSSTEEPLSKRLQNFWAASRKSHQNPEPTTYPEPLKGPSLNQSTSDVRMTSQVLSNRKVTLQRSMTATPRTRFSPPKPSLLEQLDLTPTRRTSGPRPQPGKETGVTSTTNHRDSEDDGRLFGNGHERRDSLPPLSSFDMTNIDDLDDDDDPINDPFARRGSVQRIIPSPDPQSKKKRNIESDYPPHVLREKSFNDLQSEPFDHTPTAPTAPSKTTTTTTAPISVPGPKATSEDKLSFLLNSTDKDRRNFFSTLSIDSWEDYGDLLIDQFSNALSKMKDLRHARRKTAAVFEAEIRRRNEVVEEQSSDLSRKFEEMRSGGAEVLRGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL66</accession>
    <name>A0A317WL66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467341.1">
        <property type="nucleotide sequence ID" value="XM_025611734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL66"/>
    <dbReference type="STRING" id="1450535.A0A317WL66"/>
    <dbReference type="GeneID" id="37113877"/>
    <dbReference type="OrthoDB" id="5360893at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050312">
        <property type="entry name" value="IolE/XylAMocC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110:SF57">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12110">
        <property type="entry name" value="HYDROXYPYRUVATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="1">
        <location>
            <begin position="26"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="37695" checksum="36DCB847A4507EE5" modified="2018-10-10" version="1">MPCQPAIASMSVSRAWVHSLPEKLSQIAQAGFKGVEIFHEDLEYLAKGKGEPNEDTLLAAARETRAICDQHGLQVIGLQPFMFYEGLLDRQFHQQKIAKLHTWFKITKILGTDIIQIPSNFQPDGISGDLDLIVSDMKEVADLGLQQTPVVRFAYESLAWGTYVSTWDAMWEIIQRVDRPNFGCCLDTFNIAGRVWADPTSLDGKVPDADTVLAESLARLKKTIDVKKVFYVQVVDAEKMQQPLVPGHPFHVEGQPARMNWSRNARLFLYEEDRGGYLPVVEVARVILKDLGFEGWVSMELFSRTMSDPDPSVPQTHAHRGIQAWKQLAYELNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN73</accession>
    <name>A0A317WN73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_546677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467039.1">
        <property type="nucleotide sequence ID" value="XM_025613304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN73"/>
    <dbReference type="GeneID" id="37115447"/>
    <dbReference type="OrthoDB" id="4498167at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="112" mass="11697" checksum="4C32AEDC3A8AF6A4" modified="2018-10-10" version="1">MATAMQDDQFHSMPPTSGEGCRPPGDPYARAADPHSSVEDYSRVMLEYTQRRMADFADLDDDKGSFSRSSRSSQTSGGSGTSTSGLLARQAAGASSAAHDSPDAAGYKSGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNB1</accession>
    <name>A0A317WNB1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_55700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467616.1">
        <property type="nucleotide sequence ID" value="XM_025613909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNB1"/>
    <dbReference type="GeneID" id="37116052"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="169" mass="19375" checksum="5DB30CFF620C8CCE" modified="2018-10-10" version="1">MYFCYCSFFYCLHLNCNTSSMLYHRCSIFELAYCCLHDCEDLSGSPFSSDAEDIHSGFWNNITHDGRHFPIHHCVYKTASKPKTNKAILLNSYMAPCTFLFTIACMKLPLSLGQTKSYSTAHTLADPMRHYLRFLRASKAPFETEEEAVLETRSSATVKQPILLDLYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WR50</accession>
    <name>A0A317WR50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Delta-12 fatty acid desaturas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_595266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468258.1">
        <property type="nucleotide sequence ID" value="XM_025616220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WR50"/>
    <dbReference type="STRING" id="1450535.A0A317WR50"/>
    <dbReference type="GeneID" id="37118363"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="436" mass="49713" checksum="5DE81F3915A09E17" modified="2018-10-10" version="1">MELEPEKTGFHTLAEPHPTKLVEGGVLGKDATVDDLRRAVPDYCFTPSLFWSFFYLFRDLAYSGILMTALYQLLNTTAVQESSLLYYFTVNVYGVCQGIVWTGLWVIAHDCGHSGFSHSAMLNDSIGFVLHSSLLAPYFSWKSTHRRHHIYANHIEKDLNYVPPQRQSYAEKIGQAVEVLEDIGQDAPLVLFLRIVLQQTIGWNWYILTNITCPPSAVPKKGMSMWRHSHFDPQGALFYPSEWLSIVLSDIGCLATIAGLYHLYTVFGSFETVFWVYIVPWTWVNHWIVMITYLHHTHPAVPKYTPESWTFLRGATATIDRDFGIIGTHFFHHISSDHVTHHLFSRIPHYYGPTASKAIIPLLGKHYHGRGEFNYQALETSFSRCQWVEEDLGKDVAFGLRTADAAGEKDAKSTGLWYRSGRSPLPEYKMRGSPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WS55</accession>
    <name>A0A317WS55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NRPS-like enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_623668</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467923.1">
        <property type="nucleotide sequence ID" value="XM_025617167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WS55"/>
    <dbReference type="STRING" id="1450535.A0A317WS55"/>
    <dbReference type="GeneID" id="37119310"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020802">
        <property type="entry name" value="TesA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF267">
        <property type="entry name" value="MALONATE--COA LIGASE ACSF3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00824">
        <property type="entry name" value="PKS_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="594"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY88561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="957" mass="104942" checksum="FC3A013818B879D0" modified="2018-10-10" version="1">MAPHVIEANTQFPEPTSKAIAAKDVPVTSIESTVQNLAQLLARASTSTAGLTFYSSGAEPTRVSYAELQRNAAEKARALLRIDGLSPSSIILLHFENNRDTLVWFWAATLAGLLPALSTPFVHDPVQRKKHLHHLQTLLQEPVILTNERLVPEFLELEELRLHPVESLGKAAISNGLASTYTLPGIEKKSQDAAVLMLTSGSTGSAKAVPLRHGQLLAALQGKKAHHGTEPGDVFLTWVGLDHVASMCEIHLHAVSLAANQVHVPASELLRDPLRFIQLLDSHQVAYTFAPNFFLTQVRDALTDNSAVKADLSRLKSINSGGEANVVATIDGLTRELRRFNIQREVISPGFGMTETCAGCVHAPASPSYDLAQGLEFASLGPCIPGIEMRVMRLTAKDEPAARGEVGELQLSGPALFTGYFNNPEATAAAFTADGWFITGDLAWLDDSGYLNLAGRTRDTIIVNGVKWSATEIETAIEEERIPGVVPSYTVAFPCRAPGSASEDIAIAYCPTYAADDAATRFETATAIAKTAALLTGRKPAHLIPLPAELLDKSSLGKISRTKVRTAFEKGEYASMEAEDTEAVQRYRESTQRPAKTETEKRVQSTLAGLLQIPLEDINVDMSIFDLGITSFNLILLKAMIQEAVDAPVEIPMSVLMTDPTTTAISAAIDKLLSQPPVYNPIVPLQPHGTKIPLFLIHPGSGDILVFIALAAQFPTRPVYALRTRGYNTNERFFHSIQETAETYVHYIRETQPEGPYAIAGYSLGSTLAFEVGKVLEAQGQEVRFLASIDYPPHIRQYVRGQNWIDVLLHIAFFLELIDQKIMAEAGKYLHGQEISRQDALVHVLSISDQERVRALALNPERLERITDIGENFRVHGESYEPEGTVERLDVFVADPPSYAALNRQDWEENKLGAWRNFSRTEVGFYNCPGIHATMLNPVYVPEFVRSFKLAMKRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSC7</accession>
    <name>A0A317WSC7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-gulonate 3-dehydrogenase</fullName>
            <ecNumber evidence="8">1.1.1.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-gulonate 3-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_464259</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.45" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468284.1">
        <property type="nucleotide sequence ID" value="XM_025608055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSC7"/>
    <dbReference type="STRING" id="1450535.A0A317WSC7"/>
    <dbReference type="GeneID" id="37110198"/>
    <dbReference type="OrthoDB" id="2021159at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050104">
        <property type="term" value="F:L-gulonate 3-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF1">
        <property type="entry name" value="LAMBDA-CRYSTALLIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016340332" description="L-gulonate 3-dehydrogenase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="13">
        <location>
            <begin position="9"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="12">
        <location>
            <begin position="203"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="10">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY89373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="337" mass="37194" checksum="1258235C7B221573" modified="2018-10-10" version="1">MSASRPQRIALIGLGTIGISMAALHLSRDSNIVDVFDTRPDFEDYIFKMLPNYMGQIPSLSSKQNPDARPSTSLVTSLVSSGRLRIHSTLESACASATIIQEQGPENVDWKQSIWAQVEAVAPPSAHLWTSTSGIAASTQQLQMRNKTRLLVVHPFNPPNIMPLLEIVPARGTSPERVEFAREYFSISGSKHRPVVIRKEIPGFVGNRLAFALLREACYLVKEDVVDAKDLDTILMASLGPRWAGNGVFESYQQGGGEGGIRAFLEKLGETMQNVWDGQGRVNVLGDEGTEWKEKVIAQVDEAYGTLSAEQIQEKEARLKDFVRIQTKKYTPEGPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSH6</accession>
    <name>A0A317WSH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD-repeat-containing protein Slp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_534565</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468043.1">
        <property type="nucleotide sequence ID" value="XM_025611578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSH6"/>
    <dbReference type="STRING" id="1450535.A0A317WSH6"/>
    <dbReference type="GeneID" id="37113721"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="346"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="391"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="474"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="605"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="83"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY88681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="668" mass="72595" checksum="BC0F96F2980B3518" modified="2018-10-10" version="1">MATPIVSTPVKTHHGIFSTKTAGGRMPLTPSPRTHAGSVTSNHSSPFTPPCGAQETGKEHGKSVYGGNLSSYFAKSVSRTARTYRESPKSNIARARTRKSPRHLELGVSEWALTGTGPSSQTPSKERLRKEVTRKEVVKEVTKKEVPRKEAPRKEVARKEVTRKEVPRKEVSRKEAPRKEISTRTTRSGKTTVRIPHTAGDRFIPNRTASEGLVTAGTAKPEESQRPKTSSNDGSSVLASAASAFDIGGRGTEEDITAALESLGLDDGETTTSYTKPAPDAVAYESSLADACGVNLNTRILAFKPPPPESSKPIDLRAQYNRPLKSAKSQSAQFRRRVQTAPERVLDAPGLVDDYYLNLLDWSSGNQVAIGLERNVYVWSAESGSVSCLLETSPDTYVSSVKWSGDGAYVGVGLGTGEVQIWDVEEGTKLRSMFGHDSRVGVMGWSKHTLSTGARSGLVFNHDVRIAQHKTAELVSHTSEVCGLEWRPDGAQLATGGNDNLVNIWDARSLSTPKFTKTNHRAAVKALSWCPWQLNLLATGGGSYDRHIHFWNTTTGARTNSIDTGSQVTSLRWSNHYREIVSSSGFPDNSLSIWSYPTLVRNVEIPAHETRVLHSCLSPDGQLLATAAADESLKFWKIFERKPGTSASASREGGVGSKAEMTKSMTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT78</accession>
    <name>A0A317WT78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_594175</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468450.1">
        <property type="nucleotide sequence ID" value="XM_025616195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT78"/>
    <dbReference type="STRING" id="1450535.A0A317WT78"/>
    <dbReference type="GeneID" id="37118338"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000004">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000040">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="342"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY89539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="384" mass="42583" checksum="886247A505538F8C" modified="2018-10-10" version="1">MAELNVSERLALITENLQEVLNLDLIETILAEGRNPKIYWGTSPTGKPHCGYLVPAVKIAQFLAAGAEMTVLIADLHANLDSLKSTFEQVEYRAKYYEFTITALLQAVGVSTEKLRFVRGSSYQKNMDYVMDVYKLSSLVSEHDAKRAGAEIVKQSSNGPLSGLLYPLLQVLDEQYLDADAQFGGLDQRKLFAASTEWHPKLGYRKRAHLCNAMVPGLSGGKMSSSEEDSKIDLLESVDSIRKKIRKAQAAPKETDNNGILAFAQYVLLPVSTLKNGRPEFRVSRERDGLEPLVYTNIEQMHEDYKNDILSPQILKPAVAEAIIELTAPIRAAYEASPEWQEVTLKAYPPPAPKQKKDKKKDKGSRHPGAAAGAKEETPKPVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUI3</accession>
    <name>A0A317WUI3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_464018</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468392.1">
        <property type="nucleotide sequence ID" value="XM_025608047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUI3"/>
    <dbReference type="STRING" id="1450535.A0A317WUI3"/>
    <dbReference type="GeneID" id="37110190"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000670">
        <property type="entry name" value="Serine/threonin protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="49"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="400"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="524"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="593"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="664"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY89481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="858" mass="94393" checksum="351D9D45A5C1C7DE" modified="2018-10-10" version="1">MDSSRASRFLDPAVAAITKHKAEAIKLAREQGAAVQEMCRRAKTETPPYEFEELIGKGSYGRVYKGHQLPSRKVVAIKVMDIDSMDYKSVRDFKDESIKDFIHETKVMKQVKDAGAKNINELIEAHSIHSQLWLVSEYCPGGSVRTLMRATGDRLEEKFIIPVARELAAGLRAIHDAGIIHRDIKAANILIHEEGRLQICDFGVAGVLQSQMDKRSTWIGTPHWMPPEMFSTRGEAHKYGSEIDVWAYGCTLFEFATGNPPNSNLRERMQIGRQLTRNTPKLDNSKYSDGLKSIVSFALESNPISRPAMADVLAHPYIADTAEAYPTSSLSELVRMYYQWSQRGGQRISLFHPGGAVAAELPEDEGGYEEDWNFSTTDGFERRFSVIDLDQLAASLAEMEDQISPTTTTSSENDLPEEPSEEVMTVEDQANFDERVRRGAAAMEGLFNEDMPSYKYETKNDFVPIEPKAPVSDLPLRTDTDRSSVTSTFIDIDIGSFDSSHYAAGATSAQPFQLADADTIRANRTSGRQHRNSAESRSRSSSSGVSSNRDEEDMTYQPASGPRPPTMDWKFPVFMQPPEEEAEAASEPASEPPETKPAEPDTSDKRATMEWTFPVMTAPADDGPANDSLADAGRYDTLKAPIIEIPPPSATIRRSSIGEPGDSRPSTSRSGESNASVSSEMDYDPFRFDRPSTPPANSGPGPSQPEYPGLMHSLQYSNYGQTHIMDGPGPDEEEEPEWKPSEDDDPSLSEPFPTAIPTKGLDLSLPFVPSASSSVSDSLPTARTTFPALTTDDGEPILFPDLTLPQLDIFMSGAGDHAISSELDRLLESFIDSLNATGRALSRVSLEETKTEAKPDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUP7</accession>
    <name>A0A317WUP7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Swiss Army Knife RNA repair protein HAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_516348</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467763.1">
        <property type="nucleotide sequence ID" value="XM_025609959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUP7"/>
    <dbReference type="GeneID" id="37112102"/>
    <dbReference type="OrthoDB" id="5596992at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018812">
        <property type="entry name" value="SAK_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF23">
        <property type="entry name" value="OB FOLD-CONTAINING PROTEIN, NUCLEIC ACID BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10307">
        <property type="entry name" value="HAD_SAK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife RNA repair protein HAD" evidence="2">
        <location>
            <begin position="62"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="566" mass="63804" checksum="193D93DC0BB1256B" modified="2018-10-10" version="1">MRSAKAVVTENAAAAMRVQAHGSPSRTITSLRRWSIINKELPAVSQVRSIHVYDFDNTLFLSPLPNPQLWNGPTIGFLQAYESFANGGWWHDPKLLAATGDGIEKEEARAWEGWWNEQIVQLVKLSMEQKDAITVLLTGRGENNFSDLLRHMVDSKKLEFDLICLKPEVGPRGQRISTTMEFKQTFLEDLVLTYDQAEEIRVYEDRPKHVKAFRDYFEQLNRRLQAGPTGTRKPITSEVIQVAEGSMYLAPVTETAEVQRMINSHNLTIRNPSANRAKSPYGRLRIKRTIFYTGYLISNSDSSRLIRQILNPMLPFGLADSNDLKYMANSILITPRPAPRSILEKVGGIGKKLNWQVTGTACYENRIWAARLTPVPATEKYYTENPHPVVVLAVRKGARPIDAGKIQNWHPVPSDKALTMETVVGEKVVLRVEEENPNEGEWESQFLNKNNKRRHQQERDEEILYPDQTQDGPSHGRPHYNPRYGGSNRHQYEDGPRRGSYRGRGRGSAPRGRGQNRGGRGRGRGRDTGPPGGYRSLDDYGGGYEGNHYEEKPGGNSGGGGPVMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WV93</accession>
    <name>A0A317WV93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBC-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_489620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468657.1">
        <property type="nucleotide sequence ID" value="XM_025609093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WV93"/>
    <dbReference type="STRING" id="1450535.A0A317WV93"/>
    <dbReference type="GeneID" id="37111236"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000093">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcF), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="3"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY90279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="185" mass="20718" checksum="D8B76620FCB2FA1D" modified="2018-10-10" version="1" fragment="single">MTTSTKRLLREATELSTHPSPYFHAAPISDTNLHDWHFTIQGPPSPSPYANGLYHGRIVLPPTYPLRPPSFRFLTPSGRFEVNREICLSISGHHEETWQPAWGIRTALIALRSFMDGDARGQVGGLDVGAEVRRRYAVESRAWRCDGCEFVGGRELGGVMAEWRGVCRERGVEVGVEEEEGVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY17</accession>
    <name>A0A317WY17_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endonuclease III homolog</fullName>
            <ecNumber evidence="8">3.2.2.-</ecNumber>
            <ecNumber evidence="8">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <shortName evidence="8">DNA glycosylase/AP lyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">NTH1</name>
        <name evidence="11" type="ORF">BO94DRAFT_513269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="8"/>
    <dbReference type="EC" id="4.2.99.18" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY17"/>
    <dbReference type="STRING" id="1450535.A0A317WY17"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000003">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000014">
        <property type="entry name" value="Endonuclease III homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03183">
        <property type="entry name" value="Endonuclease_III_Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030841">
        <property type="entry name" value="NTH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="182"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY91326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="883" mass="101255" checksum="73A6EBCEB9C222CA" modified="2018-10-10" version="1">MRTSRASKDTAKVLQALSPPARRQTRSSHALSLLRDFAYNGGGPAAASISDDDTSSLSSVPTVDIEDLLEPPAKRRKSALSAPRKTSTRSSRRVAERPASIKKELEEKPVRARRVPARKIKRESGDYTVEPPSNWETMYAMVKKMREENPTAPVDTMGCAELYWRASSPRDRRFQTLIALMLSSQTKDTVTAVAMQRLHTELGDQAVIIVKKEPDEYKWKPTEQVKDSTLNLENILAVAPERLNELIRTVGFHNNKTKYIKAAALIIRDQYDSDIPSTAPELMKLPGVGPKMAFLCMSAAWGKHDGIGVDVHVHRITNLWGWHKTKNPEETRMALESWLPKDKWHEINKLLVGLGQTVCLPVARRCGECDLAGTKLCKSEIKGLVSRKRNTRLISFVDLPENIKKKIFEYVGLLRPCLINISFEQVRSKLDRGLCSRPNEQRAPRGGWTASWTSFYEGPCDHPKLPIEVFQSCQAFREDAGALFFAHNRFSMLLYSKSDFVTFRTSMEWGMHHMRYLHLDLGPRDNRFLKIAPGVHRTILKMWVDFCDMSRTQMPSLRYFSMKCKVRDLEVACKLMCMMDPFPALFHCAFHLGHTQDDDIRPVIKRAAWRLTDNLPNKPPFQFSRLPKEIQLMVLEEILLNRSDPTLQPSDCAPGIITFQDRKRSRIAMFHSLTCCGTCSPLKAMCFCYARQTAFSTSCTCFSSPLPYFLVSREFYENARRIFFTKNKFAFVEEDPEYMMRFLHYIPTASTLLIQHLSFKFPVCYRSAPRTGPRSEDATMLSWSVLRRFIREHFDLSRLSVKIVDLGLKGAVVYSQENRKRYLRKLLFAFSDLAGLREFRVYLADDHIFEREAETAVLGPIRVERKRPGVPFISRQYLESVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYG6</accession>
    <name>A0A317WYG6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_533811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468685.1">
        <property type="nucleotide sequence ID" value="XM_025611401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYG6"/>
    <dbReference type="STRING" id="1450535.A0A317WYG6"/>
    <dbReference type="GeneID" id="37113544"/>
    <dbReference type="OrthoDB" id="3650366at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY90307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38789" checksum="61AF2AB0A2D1D643" modified="2018-10-10" version="1">MTVTTPRRLLLVSIPRSASNLLLKILDILNQPNVLTNSEAGYFFFPAFIPAMQGGYLDKPMDQWTDAMKQEVKASFNGCVERLEEFSARAEEEKKFMFTKEHAYWFINPAALHEMFTGTEDAKLYEAFRLRVAETYGPQSFSPANKTVLPDAYLRSWQLAFIIRHPALAWPSMYRAMAKISDIGGMGEKEIRGVWSTNMTLRWTRMVYDWALEQGTTPAILDADDVTHNPLAVTRFCELTGLDKETLKFQWSEEGTKESGPSVGNESAEALDMRLKINSIMRSTVDSSSGIIKNKTPSTIDLDVEIKSWKAEFGEEVAKLMEKSVLESMPDYEYLKARRVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYT1</accession>
    <name>A0A317WYT1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavin-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_565057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468805.1">
        <property type="nucleotide sequence ID" value="XM_025614472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYT1"/>
    <dbReference type="STRING" id="1450535.A0A317WYT1"/>
    <dbReference type="GeneID" id="37116615"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY90427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="581" mass="66322" checksum="9000C71E7A5CE867" modified="2018-10-10" version="1">MNRLAQLFVASAAKSPGQPADSWIVEERSVDEARPLRVVIIGSGISGIIASIRFRQRIPNLDLCVYEKNVDIGGTWLENRYPGCACDIPAHTYQATFEPNKEWSAFYATAPEIHRYWGRVVDKYGCNRYIKFKQQVVEAVWKEKDSKWILQVKDLHSGSVYADQCDVLISATGFLNNWKWPDIPGLHDFQGMLMHSARWDKSFDYSNKRVAVIGNGSSGVQIVPGMLPKVARMDHYVRNRTWIAPTFARAELDRRGVKSDNFSFTPEELETFNKDHNAYQKFRKDIELQLQSIHGATLLGTPEQLGAKEAFTQDMRRRLSSKPELFEELVPSFPPVCRRLTPGPGYLEALTDEKIDIITSEIVRIDADGIITADGTHHPTDVLVCATGFDTTFTPRFPITGCNGLSLAERWKKTPESYLSIAVDEFPNYFICFGPNSALGEGNLLLLLERVIDYFTSCVQKMQRDNIRSMSVQKDAVERFTRYCDQYFSRTVYSEQCRSWYKGGEKDGRVIGVWPGSSLHSLRVLSQPRWEDFRYEYVGDNANGWIGNGWTENEKNNDINVDYLDDDQVDFPWAVFEPLKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYV6</accession>
    <name>A0A317WYV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_545395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468311.1">
        <property type="nucleotide sequence ID" value="XM_025613234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYV6"/>
    <dbReference type="STRING" id="1450535.A0A317WYV6"/>
    <dbReference type="GeneID" id="37115377"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="868"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="988"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="883"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="921"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="988"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1054" mass="113823" checksum="AF0185EA2B7D2061" modified="2018-10-10" version="1">MANNSLSARCKAASSLRITPSNSPVLRPPTRSSVHKTPLNQTTLSLQTVIGTTTTTPHGFSSHEESKSFALCAGSVVVLAELDDEHCVNQRFFRARPSAASVNPVTSFYSQSTPPTTPDSRAKFSGSIRSTTHSNAYNGSPSNDPVDNGSPRGWSSRERVKAVTSTAISPNGRFLAVGETGYSPRVLIFSTAKDASSEIPLSILTEHTFGVRGLAFSSDSQYLATLGDVNDGFLFVWSVNLKTGSAKLHSTNKCTSYVRDMCWMGQTLITVGVRHVKVWRLPDARPASPRSRLTVEAPSISPNHTPRAFSGRNCLLGSLAESTFTSVASISDRESVVGTDTGALCFVDDSEGSQKLSVVQHMEFGIASLAVDSYRSCVWVGGRGGQIQQCTFEKIRSSTVPLSPALSGRSSAEQGFKGPAIVCLGSLGSHLVTVDMTNAIDIYSSNNVSEDVDQRDAQNRICAHRDGVLGIRPLQTPNQLEADFFTWSRKGTVNFWNTQGKCKDSRTIALEHPAGNDEDISNELKVVRTTDDMDRFFSGDKFGVLRVLQGDSWKSVHEVRAHGGEITDIALHITPESCLVASSGRDRMVQLFERNNDKLQLIQTMDDHVGAVSQLLFIDDGEKLLSSSADRTIHVRDRVTREVDGEPVIAYLISRVITMKASPVSMTLSTDTDVLVVSTADRCILQYDLASGRQITSFRAIDSDGSDTVVMNSLTVASDMSGQSFSKLLVGVSGTDKSIRVYDLERGVLLTGEFGHTEGLSDACLLDHHSSSPASPNGRVLISSGLDGLVMIWGVSMLPQSSQDVAQAVIKDDDAPVKELTVAKPPLRKILSKHELAGLQRQENIAVTPTPARGHSPTFLRKFSKFSFSTSTKNGHTPPPTTPSSTSNRRSPVPSVRREKPHSSSPSLHTSKPAGMRKSGGRSDSRRSSLDFRARARNSGKSDFGSLDTSTEQVCRTLKAYRKKLNGSTEHVHAQKELERELSLTLRALTSRSHSSESAETETESSGKENEKLVGDGASNNTIYAPCSIPSPDERSNETPEASVGLSVHADGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZQ6</accession>
    <name>A0A317WZQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="2">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_555996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468601.1">
        <property type="nucleotide sequence ID" value="XM_025613833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZQ6"/>
    <dbReference type="STRING" id="1450535.A0A317WZQ6"/>
    <dbReference type="GeneID" id="37115976"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00114">
        <property type="entry name" value="DeoC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY89690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="271" mass="28800" checksum="2383F5794C211380" modified="2018-10-10" version="1">MSKTNTITVTLSDLAKTIDHSLLHPTLTDASIIAGLHLAKNYNVATACIKPASIDLAKKVLAGSSVLICAVIGFPHGNSTTNIKILEATEMVRVGAAEIDMVVNIGKVLGGDWEYVSAEIKAVNDAVVGGGGVLKVIFENDYLGVEEIGRLCEICTQVGVGFVKTSTGYGFVKQADGGYNYKGATARDLKIMREKSGERKTLDDLLHVMSLGVTRIGATATVAILDETKKRGIGNEPVEVEFKPMAEEEIGAPPLEDPQGLADPWHPELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0J0</accession>
    <name>A0A317X0J0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hscarg dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_617221</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469523.1">
        <property type="nucleotide sequence ID" value="XM_025616825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0J0"/>
    <dbReference type="STRING" id="1450535.A0A317X0J0"/>
    <dbReference type="GeneID" id="37118968"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF11">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="305" mass="33924" checksum="B1EC3EAFC56A520A" modified="2018-10-10" version="1">MSPKLLTIIPATSQQGHSILTTIHTHPTLSKEYTLRGITRTVTSPTALSLKNQGIEVVSADLNIPETLSPAIASSHTVILITNTTYASPDFKSLELAHTKSVAKACLEAGVQHIIFSSAVPGKANWEGRPVDVFDSKATAEEYLRGLPMKVSVFWPGMFMQNFEGFMKPTLSQAGEWVVNCVVDGEKKLPMVDAAGDMGAFVVPLLMGEERTYAASGVWSFNEMVEVIRRVSGRKVRYERMDEEVYAGFMPGQMGPKVVEMLRFYDEVGYYGGDEEGKVRETLEVVERKVSSFEEFAERRLREWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X123</accession>
    <name>A0A317X123_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_513206</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469020.1">
        <property type="nucleotide sequence ID" value="XM_025609834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X123"/>
    <dbReference type="STRING" id="1450535.A0A317X123"/>
    <dbReference type="GeneID" id="37111977"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF7">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="582" mass="63410" checksum="F484885FCFD533FC" modified="2018-10-10" version="1">MRQYSRAAVAALAAATANAASLSDICTVSNVQSALPSNGTLLGIDLIPSAVTANTVTDASAGMGSTATYDYCNVTVTYTHTGKGDKVVVKYAFPAPSDFENRFYVAGGGGFSLSSDATGGLEYGAASGATDAGYDAFSYSYDEVVLYGNGSINWDATYMFGYQALGEMTKIGKPLTQGFYGLSTDQKIYTYYEGCSDGGREGMSQVQRWGDEYDGVIAGAPAFRFAQQQVNHVFPATIEHTMDYYPPPCELEKIVTETISACDPLDGRTDGVVSRTDLCMLEFNLTSLIGTSYYCAAQNYTSLGFGFSKRQAQGSSTSYQPAQNGTITAEGVALAQAVYDGLHDSEGNRAYLSWQIAAELSDADTTYDSTTDSWTLDIPSTGGEYVTKFVQLLNIDNLENLDNVTYDTLVDWMNTGMIRYIDSLQTTVVDLTDFQKAGGKMIHYHGESDPSIPTASSVHYWQAVRQAMYPNVTYTDSLKQMSDWYQLYLIPGAAHCGTNSLQPGPYPEDNMEIMINWVENGVKPSRLNATVSSGTYEGETQMLCQWPSRPLWSSNSTFSCVHDQKSLNTWDYTFDAFKMPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X131</accession>
    <name>A0A317X131_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_488802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469030.1">
        <property type="nucleotide sequence ID" value="XM_025609074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X131"/>
    <dbReference type="GeneID" id="37111217"/>
    <dbReference type="OrthoDB" id="10010954at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016259803" evidence="1">
        <location>
            <begin position="18"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="287" mass="32791" checksum="C801D0880C2B3C65" modified="2018-10-10" version="1" fragment="single">MHLLCLIFLPLIGATPASYTFNQLWSLTTHFWDNFLYPANTAHISPNDTSIFADNVQGRVDVTRTFSNRDLNNEYIFGLFSQPTHPGIFGVPIAYNITQFAATQDTAASTTVITFNISTFDLIIPGVITAWFQFNSAGQVTQYDAVFRWLDLLFTQIMQAAGRKFNTSDPTEIESRVADLFARTICQTHEKYCIGQNRQYTSEDACYVFLTQQIRFGQPYEMGRNTLLCREVHDNMVRYNPDVHCTHIGPTGGDYCVDDQTYEGVVLERYFRASWVPENYAPENVWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X254</accession>
    <name>A0A317X254_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_514562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468998.1">
        <property type="nucleotide sequence ID" value="XM_025609894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X254"/>
    <dbReference type="STRING" id="1450535.A0A317X254"/>
    <dbReference type="GeneID" id="37112037"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY90620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="541" mass="61978" checksum="1A123AD7B020BD8A" modified="2018-10-10" version="1">MSFFDIQLRTAIVTGLLSHWTFFIHGERDLAAASIARFHLIVASLVTFLNWRLGEFPIRDAFRQAVVLVAAYAGALFTSTLLFRMFLSPLNHIDGPLSLRITKLTHVWKQARYRNCEVLHELHQKYGDVVRTGPSEVTVFGTEAFYKVHGKESHCARAAYYDLLHPLVSLDTTRDPVMHAHKRKVWDQAFSVRAMEKLEPVIYRKADLLVKQLQNQKQNPVDISVWLEYYTFDLMGEFGLTIDFKNLERVRPHPILTLYHMAHRSLGPLAAAPWIKHLLMGIPYIERMKYYRQFMDWATAELGRNINVRMIYRTDIIGYVLDDARQTGGIEANWRFVLGDFALVIAAGSDPMRQVLANLLYYLAREPIHLQQIREELGSIDMRDYKALQQSPHLNACIYETLRLNPAVPSSGLRLAPSEGLEVAGKFIPPGTTIAVPQYSLFRDERNFVRPLDWIPERFTSQPDLIRDKQAFMPWSAGKYACIGKNLSLMEIRVAAALILTTFDYEFAPGEDGQRIFSEAADYFTTTPGPFYLVMKNRGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2M8</accession>
    <name>A0A317X2M8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_617518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469600.1">
        <property type="nucleotide sequence ID" value="XM_025616831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2M8"/>
    <dbReference type="STRING" id="1450535.A0A317X2M8"/>
    <dbReference type="GeneID" id="37118974"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="48497" checksum="DD6EF3AB8A935277" modified="2018-10-10" version="1">MTHIHPPTTEETCKRRLLLIYIHGFMGSEASFGDFPAHVHSSLKEVLDESHVIYTRIYPRYKSRGEISMAVENFRAWLSPHIADDLDVILLGHSLGGIVAADVALLSASEASTTTTPTLTNRTRILGLVNFDVPFLGLHPHVIPTGIRGLFRRKEDPTSIDTTNGIPDTATDALFDPPFVNDVHLVERDRINGIMHFIQKNHQHLVRSIYERVLSPYRFAGGLNNYGMLRRRYQRLMVLEGGDGDGSLSGGRVSGVVGEGEEGKVKRRGKGREEMVTVHDSALLETETCTVYASPSKSAEQLQFTNSLSTLDLSTDEDSTAASECSLEVTESSIQENNSIATQVDKATKKAPSKPHKFVLMPSHHWKHGDNSLWVPVQMENMDEVTAHQSMFVPHGDGRSYEKLIGEVVSQIESWVKDDLSERLLQAESRSSMELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3A8</accession>
    <name>A0A317X3A8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nitric-oxide synthase (NADPH)</fullName>
            <ecNumber evidence="3">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_622291</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469870.1">
        <property type="nucleotide sequence ID" value="XM_025617068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3A8"/>
    <dbReference type="STRING" id="1450535.A0A317X3A8"/>
    <dbReference type="GeneID" id="37119211"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="517"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="11">
        <location>
            <begin position="692"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1036" mass="116537" checksum="D9BB0F1A139F2FB6" modified="2018-10-10" version="1">MPLTRSTPNAEAMPASRCPFAEYDKILERNPILAPTGCTDKFCQAGRLVHTDEPKVGENHPIEIVRDEASAFLWQLWQDGIYTENRYSERKEQVMEEINRSAKDKIVWIQGAKRVGKTSTWMQTSEELRYGLQLAWRNSRKCIMRSRYQELELCDLRHIQTSVEMVTALLEEITKSFNDGQIRPTVFAFPPKSVDGEGPMFWNKQVLGFAAYELDDGSVLGDPSNIQLTRDMIDLGWTPPCPKTRWDLLPIVAMAENDAPAMVELPDRLRRLIDIEHPDYPGFGKLGLKWYQFPALSRLGFDIGGVQYTAAPFLGWYMDAEIGVRNLADTFRYDSLPDVAKVIGFDIDSYRQRQEYSEVRAMEDLPDYEQLRWLSRAQAELNYAVRCSFLKRGVTCVGTLAASSDWCQYDDDYAAKNGYRLNSDPYWISPPQGSIVPIWHRGGAPNYQPKPMICRNRYDPVKCWQRRKSATDADPVRLVRKEERWVTETLSTFAAGWSNGHGSVGIDHLSQGPSNTVRICYCSKGTTARNLADKLHRSVKKKCTKGFRVTFTSLNALDLHKVDPSDVILVVASTTGSGAFPSNGEEFAKARGHMLRTHTADFSQLRVSVFGVGDSAYSNFNAAAIDVYDFFRELGVLQIAGGLVKADVAAEALPLRLFNRWLEAVESSLTGGVGELRENPEEEFMAQAVMLHQFDTATLLSKSSPATGEDERLIVMTLKGVEYGEMKHLRLLPTNSSSQVARAMAALGIADAQKLVPFSDPKLRQWTYQEFLSCFVDLEDRFKTQSWTNQPRKDNETVIETLERCATVENPSQLSEALRLSICLDLPLLRPRAFSVASSSRYLGDKKVELLIKPHRHGRFSEIYLATLQPGAQVKYSLVPTAPAAGFLAVQTPLIAITTGSGFAPVRSLLQHRIHIVQTSQAQSSKAHPFENSPISLFAGFRLLDGDIIRSTTSLAERHRVLDMSCLVPSNKEKKRVQDFLWHKRDEIRNKLVEKKGYVYVCGSAIMTEGVLAKLSQIVGGDAKQRLGDRYVEEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X427</accession>
    <name>A0A317X427_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_488817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469038.1">
        <property type="nucleotide sequence ID" value="XM_025609076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X427"/>
    <dbReference type="STRING" id="1450535.A0A317X427"/>
    <dbReference type="GeneID" id="37111219"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000007">
        <property type="entry name" value="Acetolactate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF13">
        <property type="entry name" value="ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="8">
        <location>
            <begin position="10"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="6">
        <location>
            <begin position="225"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="7">
        <location>
            <begin position="427"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="598" mass="63805" checksum="410B24CBE235D693" modified="2018-10-10" version="1">MERTDLLDHTGGEILRELLLAHDVDHIFGYIGGAALPLFDYLCKPGASTPPFNFIHVHHEQGGGHMAEGYARASNKPGIVLVTSGPGTSNTVTPMLDGLLDGTPIIVICGQVTTSAQGTQAFQEIDVLSLARSCTKWCTCVQSIADLPASIDAAFYHATSNRPGPTLLAIPKDIGQAVFDTAALHQPSHLPDSNSDTSSDSDNSNTSRASTPTLMYNTATHYDRIEHIADLINRSQRPVICAGNGVINSRNGPALLAQLSQLSHIPVTTTLLGIGSFDETLPEALHMVGTYGTPYANLAIQSADLILALGARLDERAVDNPKLYAPCARHPPSGLGVIYFNISPSTVGKVIPPTEIIPGDLSTTLPILLPHITPNPRTQWLQTIHHWKTTQSLPTPTPSPSTPITAEQIITTLKTLTPKQTTTLTAGVGQHQMHAARSYTFPLHPGIFITSGSLGTMGFGLPAAIGAKLARPTHTVIDIDGDASFCMTMVDLLTASQNNIAVKVIIMNNNGQGMIRQLKNLTKEEEKMQWCTRQGNPDFVALAESMGVPGRGCGDGGRLEEDINWLLECSGPAVLDVITEDGMRPMVNLGKGLDSITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X434</accession>
    <name>A0A317X434_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence/damage-inducible protein CinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_488024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470087.1">
        <property type="nucleotide sequence ID" value="XM_025609056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X434"/>
    <dbReference type="STRING" id="1450535.A0A317X434"/>
    <dbReference type="GeneID" id="37111199"/>
    <dbReference type="OrthoDB" id="2350783at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA C-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="173" mass="18110" checksum="7C14D54CDD6E839F" modified="2018-10-10" version="1">MSEFPPASLRPLIEEVFELLRARVETISVAETASGGLISACLLSTPGASSIYKGGLTVYTLGSRIAYTGWTPQHIDAYAGPTPGVVAEIAENVRSTLHSTYTVCESGTAGPTGAETQNRTPGYVALAVATPSGTVTREVETGSAERANNMVLFAGEGLRLLRDVLVGEIRPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4P1</accession>
    <name>A0A317X4P1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_582926</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470304.1">
        <property type="nucleotide sequence ID" value="XM_025615515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4P1"/>
    <dbReference type="STRING" id="1450535.A0A317X4P1"/>
    <dbReference type="GeneID" id="37117658"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="26"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="505" mass="54483" checksum="2B2DFCDFED8F5B54" modified="2018-10-10" version="1">MSSTSPNIVPMAKPTWLQMPPRYILASLLTAMGDFLLGVDTSIIGPVTVMPSYIDYFGSHSAIVHGIIVSSILLSASFMSFIAGRPADVMGRPLAIALGAAILGAGAALEAGAVRLAMFMVGRIVEGMGFGLYFGTLTVYVCEIAPPSVRGPLTTGPQFMICLGLVAGYFTCYGTAKIEGSMSWRLPFIILVCLAAAFVTSVLLYLPPSPRWLQLHGRGEEAHAAWEALGVKVEDRPGIEEVLEGVANSGDGSPSSLSPTRAVIEQPKTEGSLFDLFKRDVRGRTMLAIFLMGFLQLSGIDAVLYATGLSSTEASFFASGISGIVLVVVLVPALLFADKWGRRSSTIIGGIGLTTTILLIGPLYASNAVNPSHGAARWIVIVCIYFYAVFFASTWAVNIKVFAPEIQPQHTRAKATALAHGFNWVCNWFVAFICPILLEKTRFGAYFLFDGCCALTTVVCFLFMVEARGKSLDEIERAFMRSVVDEEESKGLFWYLRKVKAMKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4V0</accession>
    <name>A0A317X4V0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_563970</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470357.1">
        <property type="nucleotide sequence ID" value="XM_025614388.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X4V0"/>
    <dbReference type="GeneID" id="37116531"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038769">
        <property type="entry name" value="MTC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38426:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="157"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="610"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="802"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1191"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1326"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1428"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="292"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="806"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1195"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1215"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1253"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1274"/>
            <end position="1288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY93596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1612" mass="177079" checksum="552AC10DAB2FB8B4" modified="2018-10-10" version="1">MLRSSVAPGRQLLLSSARQRTAPQWLSRAGASSRLSGQRFFADSKPPTTAAPTPATPSSESVVPPETVPKPSPSEQGSEILTPPPPAPKGGRFRRFLLYLLLTSGFAYGGGVFLALKFDNFHDFFTEYIPYGEESVLYFEERDFYRRFPNTLRNQNRLISSPRDEGNKITIPSKSGLTSKVAEEEASGTDVSQKGPHMSASAQKSSEAQVKAASAKPEDKTTAVVKAKEEAPKAAEKKEEPRQPALPAITPLEFAQVNEGDEAIVQELVKTFNDMITVISADENSGKFSAPVAKAKEELQKVGEKIIAVRDEARRAAKEEIDQAHATFDESARELIRRFDEARAADAAQYREEFEAEREKLAYAYQEKIRTELQRAQDVAEQRLKNELVEQAIELNRKYLHEVKELVERERDGRLSKLNELTANVSELEKLTSGWRDVIDSNLKTQQLQVAVDAVRSVLERSAVPRPFVRELVAVKELAAEDPVVDAAIASINPTAYQRGIPSTSQIIERFRRVADEVRKASLLPEDAGIASHAASFVLSKVMFKKDAVAGSDDVESVLSRTEGLLEEGNLDAAAREMNSLQGWAKILSKDWLGDVRRVLEVKQALEADESYSPSPLMPKTHETQSGLPLHSNTSNDISDRRKGLHMNQGRPSGELEGSTLGNSSRDGDKGGRSQRRTASSGGFLVDSSFLPRSKSLRTSHYRPRRSESDRKEKREAPEPDLVVPKKRSRFPWIRPKEPKVSQVDQTEAKAPEEIPASSLVEQDAAPHESHTQATESQTPVGLDRDSLQIVNLALNLSESRKRNSLGRSASNRLSGGRWNLSTGARNGRNITQSLGDDHLPPVHAPSSVARSEILPQGFSESTLARAEKARRHFDLFSEYLRLLPSLPPLTRVNGHPADSASFDASSLPSYRVYNPLQCIQRCAIDTGAEGWYDIDKVHQWVDSVEAQHSQHSHSPLECLQLPSFHSCRETKPREEVDEADYLAVSPPSSLRRASRASNWIIGPAEFLSDAAWSKIVDRDGNYLYPDPSILITADANQETIGLQEQLQNNRVSLDSELPTSRTSLSDARSGLATEFRGSGRSGHATGPKKHKLGLLSSSSSSISSADGRLYRHSPMHNTLSSERDASPLPDASRLRASGALSEDDSAVDARLTPTHDTFPRYKSRISPAWALVDDRYDPLTNLATAESSIAANLSPPSSRSPSPSKGRFSRAIGSRHERSKNDSSLDSAALRKDSLLEPSPIPDRVSSIHSQTRKDALQPESKLRGIFKGPGKIAEKVGNEMSKDNTTHSRRSSISSTKARGDKISGAKSLLRRFPTFTDDANRASRKNLEKLNGKHSVPSVGQDRLEEHRPSEYSSPPKSGADAGTVEPQREAGGFSTSLHAPVTRHESSRFGPELHTVREQFKKGNIKDAGVPFSLTRPPITGLAQARADTMSPEERRPRLSNQSRSWSISNRSLSTSLVVGVPGKQEVERTRALLLSSGIKAREITRRADCVRHPPPDFLRRAFDTEASIPQVTRLYEYDVAAQGLLRRVEKTHHLFQQSMDNFSGSVSSPLKSQLSRLEGLVNETISPRVQAATQDAEDLSIQLNTTSTLAGSGGAIAGCAGYGALDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4Y1</accession>
    <name>A0A317X4Y1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18 19">Pyruvate carboxylase</fullName>
            <ecNumber evidence="6 19">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BO94DRAFT_532565</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="6 19"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470394.1">
        <property type="nucleotide sequence ID" value="XM_025611143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4Y1"/>
    <dbReference type="STRING" id="1450535.A0A317X4Y1"/>
    <dbReference type="GeneID" id="37113286"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.600.10:FF:000002">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 19" id="KW-0092">Biotin</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16 28" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="26">
        <location>
            <begin position="40"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="25">
        <location>
            <begin position="162"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="27">
        <location>
            <begin position="578"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="24">
        <location>
            <begin position="1115"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="22">
        <location>
            <position position="755"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="787"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="920"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="23">
        <location>
            <position position="755"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="23">
        <location>
            <position position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="PWY93633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1192" mass="130854" checksum="17297A405B1529D1" modified="2018-10-10" version="1">MAAPRQPEEAVDDVEFIDDHHDHHRDSVHTRLRANSAIMKFQKILVANRGEIPIRIFRTAHELSLQTVAVYSHEDRLSMHRQKADEAYMIGHRGQYTPVGAYLASDEIVKIALEHGVHLIHPGYGFLSENADFARKVEAAGMVFVGPTPHTIDSLGDKVSARQLAMRCEVPVVPGTPGPVEHFEEVKAFTDTYGFPIIIKAAFGGGGRGMRVVRDQAELRDSFERATSEARSAFGNGTVFVERFLDRPKHIEVQLLGDNHGNVVHLFERDCSVQRRHQKVVEIAPAKDLPTDVRDSILADAVKLAKSVNYRNAGTAEFLVDQQNRYYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGATLEQLGLTQDRISTRGFAIQCRITTEDPSKGFSPDTGKIEVYRSAGGNGVRLDGGNGFAGAIITPHYDSMLVKCTCRGSTYEIARRKVVRALVEFRIRGVKTNIPFLTSLLSHPTFVDGTCWTTFIDDTPELFALVGSQNRAQKLLAYLGDVAVNGSSIKGQMGEPKLKGDIIKPVLLDEAGKPIDVSAPATKGWKQILDQEGPEGFARAVRANKGCLIMDTTWRDAHQSLLATRVRTIDLLNIAHETSHALANSYSLECWGGATFDVAMRFLYEDPWDRLRKLRKAVPNIPFQMLLRGANGVAYSSLPDNAIYHFCKQAKKCGVDIFRVFDALNDVDQLEVGIKAVHAAEGVVEATICYSGDMLNPNKKYNLPYYLDLVDKVVQFKPHVLGIKDMAGVLKPQAARLLIGSIRERYPDLPIHVHTHDSAGTGVASMIACAQAGADAIDAATDSLSGMTSQPSIGAILASLEGTEQDLGLNAAQVRALDTYWAQLRLLYSPFEAGLTGPDPEVYEHEIPGGQLTNLIFQASQLGLGQQWAETKKAYEAANDLLGDVVKVTPTSKVVGDLAQFMVSNKLSAEDVVARAGELDFPASVLEFLEGLMGQPYGGFPEPLRSRALRDRRKLEKRPGLYLEPLDLVNIKSQIREKFGAATEYDVASFAMYPKVFEDYKKFVAKYGDLSVLPTRYFLAKPEIGEEFHVELEKGKVLILKLLAIGPLSEQTGQREVFYEVNGEVRQVSVDDKKASVENTARPKAELGDSSQVGAPMSGVVVEIRVHDGLEVKKGDPLAVLSAMKMEMVISAPHSGKVSSLLVKEGDSVDGQDLICKITKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5C0</accession>
    <name>A0A317X5C0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_583153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470557.1">
        <property type="nucleotide sequence ID" value="XM_025615536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5C0"/>
    <dbReference type="GeneID" id="37117679"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7325" checksum="EBA65DE62330CC0D" modified="2018-10-10" version="1">MARGNQRNQSRKRNEEQKKKLNKTKTVVGKGGLSAKKEMDAAQMRAKQALADQKKEAEALAAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5U2</accession>
    <name>A0A317X5U2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_357911</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469753.1">
        <property type="nucleotide sequence ID" value="XM_025607150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5U2"/>
    <dbReference type="STRING" id="1450535.A0A317X5U2"/>
    <dbReference type="GeneID" id="37109293"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY92992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="487" mass="54854" checksum="7DABF88716FCC981" modified="2018-10-10" version="1">MSVDEKQPVGDKEASPPPSQYAVNERKLMAKIDWHVVPCLCVMYLLAFLDRVNVSNAAILGLKSDLHLETGTKYNTALTIFFVPYIIFEIPSNVLMKKLKPHAWLSLCMFGFGLVMVCQGFVQNWGGLMATRWFLGMFETGLFPGCFYLLGMWYKRSEAQKRFSFFFSSTTLAGAFGGLLAYGLGKMEGIRGYSGWRWVFIIEGILTCMVAIGCFFIVPDFPEDAKWLTEEEREFLRDKLAKDTGKAAVDASMNWRDVIGVFKDYKIFIGGLMYFGQVVTAYGYAYFAPTIIQTYGYGSIKTQLYSIPPWAVAFGFSMLIAYLSDRFQHRFLFTIIPMLVAMAGFGVLLNIHDTAQYHVQYGALFLVTSGCYSAMPVLVCWFAMNLGGHRRRSVGTAWQIGFGNIGGIISTYSFLAKDAPFYRPGYIIGVSFLAFSAAMSIAYMVAIWHDNRKRDRAIAEGRIDPQTVTEEDEAMMGDMAPTYRYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X621</accession>
    <name>A0A317X621_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_318047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470815.1">
        <property type="nucleotide sequence ID" value="XM_025606885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X621"/>
    <dbReference type="GeneID" id="37109028"/>
    <dbReference type="OrthoDB" id="4500002at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="420" mass="46845" checksum="058DC5956EDD6660" modified="2018-10-10" version="1">MNDIIDKMDQEDLIHPITTPSFNTNTYASTTTSTTIASTHRKRAYDNANDSDSDPNSTQPHNAKRPRLPSPFTLQAERLEEALNREIQAQEDEITMHRYRMLNRRVLNEAHDRMFRLAMLPDQARDEEYNAQLRRCYELQRWEERIKGGDGDMDVDVDVDVDVDVEVDGEVGDGYECAGEDEQESEEMVVSSAGATVNSSPVHRTHHHHVQIQDDVTPKSRKKGCLTGVGAGARAEFAIYEDPVTEGYDVGVNHHEVRVYRDWDENKENVDEGDDNPNGTETETESFSQVDAHQQMEGGDGLQGEDVFGSPVGVYCYADEVEGRHLGDVDVDEEEELEYADTEVDPMDEALGDQLRRRRYSGLRRQRGQLASRSGGGLGVTEVSLNPLMQSEVLGGGGEGEGEGSQSVGVGRGRRGTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X673</accession>
    <name>A0A317X673_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_512093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469893.1">
        <property type="nucleotide sequence ID" value="XM_025609795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X673"/>
    <dbReference type="STRING" id="1450535.A0A317X673"/>
    <dbReference type="GeneID" id="37111938"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="526" mass="56336" checksum="6FEA3BA144F55442" modified="2018-10-10" version="1">MGSDTISHATIQTEASHPDDDSLKGGERLTVNENHVLQDRKIGVLGAISLIVNKIIGAGIFSTPSTIFKLSGSVGLSLLLWVVAGIISACGALVMLEFGSAIPRSGGIKVYLERSFAPKRMQTCIYLFFCLFLQVSASNAITASEYLLSAAGVESTTWKERGLAIAAVSFAVGVHTVAPRVGRGLQDLLSMVKLFTLLFIVCTGFAALAGHRRIPNPHNFDVKTSFSGTSNNGYDIGTALLDAIFSYQGYDNVNAVLSEVKNPEQTLRIALPCAMGIITVLYVLANVAYFAGVSKEEFRTASVTIAASLFRNVFGETAATRALPALVALSAIGHLLGVAFVVPRLLQELAKDGITPFPDLMMQNRPFKTPIAALVVHLGVTILFICAPPAGDAFSFVVGLSSYPMCVMLTAITVGLVKMRLSPSEGWSSSYTAPWAVIAFYLAANIFLLVMPFVPPNTSKSSIPYWLSPVVALGILGLGVIYYLLRFVVLPWLFGYSLHPVTKDLTDGSQVTRFSMQKNGSVEPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6T3</accession>
    <name>A0A317X6T3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_326795</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471040.1">
        <property type="nucleotide sequence ID" value="XM_025606947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6T3"/>
    <dbReference type="STRING" id="1450535.A0A317X6T3"/>
    <dbReference type="GeneID" id="37109090"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="156"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="318" mass="35256" checksum="F45B0A36528860B7" modified="2018-10-10" version="1">MAEQASFGQPGVSGGISATASQFTATNSFVAADYLTMPLAEENNLWTYSAMPQSMPSWPGKNESQAFPNSALEQSLKNSHVRNGQPTPPPVDGMYQISQYDQYNDSTYANPTPRGSFSQQARPGGEGPAPKRRRTNTMKSASPETDDLDLNLDLDRMKRQKFLERNRVAASKCRQKKKLHTERLQARHDELASKRDELDILVEKLRTELLNLKNELLTHAGCADEAISVHLSHMVKNITSRDTAAAEMRPDQLEALTMGSANMAPRSQTQSFGFDTPLQVQSRTDSLAVTPRRDSEHSLLTDGSYSFTDDAFEELIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7V4</accession>
    <name>A0A317X7V4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative arylsulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_563200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471370.1">
        <property type="nucleotide sequence ID" value="XM_025614344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7V4"/>
    <dbReference type="STRING" id="1450535.A0A317X7V4"/>
    <dbReference type="GeneID" id="37116487"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="7"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="159"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="503" mass="55945" checksum="DC1C29B2F7299536" modified="2018-10-10" version="1">MTASKRPNFLVIVADDLGFSDTSPFGGEIDTPNLHRLAMEGLRMTDFHTAASCSPTRAMLLSGTDAHIAGLGVMAERRNRFPHVFDGKSGYEGYLNYRVAALPEILQDNGYFTCMSGKWHLGLMKDVAPCSRGFTKVFTTLPEPHPRSKTTALLLLPPLHSPHWPLQAPSSTIQKYHGLYDDGPLALRARRLQSLIKNGLVPADVDPAPILTLGTTPWSSLPASEQQKSSRAMEIYAAMVDLLDVNIGRVRSYLESTDEWDNTFVVFMSDNGAEGQLLEAIPILAGATLGDVIEKYYDNSLENLGNHNSFIWYGPQWASAATAPCRATKSFTTEGGIRCPCIVRYPPLMNMKPGSITNTFTTVMDILPTMLDLAGVEHPGQMFRGREVDPVRGHSWRPLLESEDGDVDIYHEDVVGWEQLGIAAVRVGNWKAVFLPPPRGEGKWELYDLEKDLGEVNDLSEERPEKLVEMIAHYETYFQESGMFDSYSVFQEELKKSGVKRAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7V7</accession>
    <name>A0A317X7V7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_282165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471467.1">
        <property type="nucleotide sequence ID" value="XM_025606633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7V7"/>
    <dbReference type="STRING" id="1450535.A0A317X7V7"/>
    <dbReference type="GeneID" id="37108776"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05941">
        <property type="entry name" value="MCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF15">
        <property type="entry name" value="AMP BINDING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="459"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="550" mass="60650" checksum="ADBA2BF6A39AC8B5" modified="2018-10-10" version="1">MGLTTSLNDQSIGHSAEHLSLPLTALPSLPLFVEANVHAQNTPDKIAIVDATKGQQFTFGQLLADAAALKKVILEKLDLTEQANLEERRITFLTPNGYDYVVTQWAIWAAGGVTVPLCTTHPVKELLYTIGDSDPSLIILHPSFEKFEAPLREGISKEIPFMSLTPFQQRPGPVPLPEISPVSFLHRRALMIYTSGTTSNPKGCVTTHKNITFQAKSLIEAWQYNSSDRLIHVLPLHHIHGIINGLTASLLSGVAVEMHPKFDPKVIWGRWEEGGSTMFFAVPTIYSRLVDYFEANIRGTEHEQAARAGAQALRLIVSGSAALPTPIKSKFAAITGQVLLERFGMTEIGMGISCGLEVDKRIDGSVGWPLPGVQVRLTDKETGRVIDAVDEDGMIEIKGDNVFLEYWRRPEATSKEFSTDGWFKTGDVARRDTNGAYFIQGRASVDLIKSGGYKISALEVERKMLAMDAIQEVAVVGLADEEWGQRVAAVVKQRTGTEPLELTSLRTQLKQEMAPYKIPTVLKLVKAIERNAMGKVNKKTLVQKYWPELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7X5</accession>
    <name>A0A317X7X5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_621173</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471475.1">
        <property type="nucleotide sequence ID" value="XM_025616982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7X5"/>
    <dbReference type="GeneID" id="37119125"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF27">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="230"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="419" mass="46812" checksum="A9C9A94AF595822C" modified="2018-10-10" version="1">MAISADLLFNVVFFLQCLITIILLVRTPKGSILRWICLPSLVYMAYLEGVLMKISNHGGFFKATAGGLPFTTIIQLINLLLVTSIDFTEQPGTPKGKLVSAFFILQTLRGIGTQWQAKNVPEFPLVFKRNPPSRAQFIRRQMAIVMGEALTLVLVLMLFVPYIKSDHNGAYLYGPGREFLYADSSIEQLLARVKAAFVFGLPGLMVFLDSTYRVGSVLAIGAGISKVDSWPPVFGCLRESYTVRRFWGKFWHQYLRWSYTSVSTAITCRILRLPKPSLIERYTNLTTVFALSAAMHVVVNIIGGIEGGNTGTVLFFLSQVGAIAFEDNVQHCWAVFLQGKKINATETPLWQRCVGFMWVFCWLSATFPWWWYPIIRALEACDWSEMLDVVQGLGLTKSNLSALVVGGGVFLRIAFGAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X855</accession>
    <name>A0A317X855_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dynamin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_487610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469849.1">
        <property type="nucleotide sequence ID" value="XM_025609044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X855"/>
    <dbReference type="STRING" id="1450535.A0A317X855"/>
    <dbReference type="GeneID" id="37111187"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001425">
        <property type="entry name" value="Dynamin GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="37"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="608"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY93088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="78302" checksum="F853BAAFAACD78D1" modified="2018-10-10" version="1" fragment="single">MVRRNFSTTALEVLCTPERLELIDHIDSLRLRGISHYISLPQIIVCGDQSSGKSSVLEAISGVPFPVRSNLCTRFPTEVVLRKAAQAGVTVSIVPHQSRGSFEQVKLSAFHETLDNFEDLPPLIEKAKAAMGLHAQGKAFSNDLLRVEISGPDRPHLTIVDLPGPTHSETQQQSARDVSLVQDVVKMYMRESRSIILAVVSAKNDFANQIVLRLAREADPSGTRTVGVITKPDTLVRGSDSEFQFLSLARNQEVNFNLGWHVLKNMDTEKGTSSLATRNREESEFLSKGAWARLPRSYVGIDTLRTRLSKLLLEQIVAELPDLMEEVKTKMEDCQQQLDGLGQPRETVTEQRSYLLQISESFQSIVRAGVDGTYGGTFSGRVDAVKQYPNRIRGVVQNLNEKFAKYISEQGHYRHISHSQNDARDVTSGQTVVTRKKYIEHIELLLRESRGRELPGTFNPMIITDLFQEQSQLWQKIAENHIDEVWAATQAFIIAVVRGVSDEATTVTLLHDITAPALDDRLQAMKRKLTEVLERYRSGHPITYSREFVEIIQKVHRERFKAVLSNGLEEFIEQQNKLRHFYVNPSEIGNVLDRILASSEVGSASFAAAEALDISMTYYEVSLERFIDCVAIGVVEITLMQHLGNILSPIVIDVMSDTQVSRIAEETVGHCCLRNELLTKLEVLRKGSEICRKFVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8B1</accession>
    <name>A0A317X8B1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_531785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471605.1">
        <property type="nucleotide sequence ID" value="XM_025610975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8B1"/>
    <dbReference type="STRING" id="1450535.A0A317X8B1"/>
    <dbReference type="GeneID" id="37113118"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="170"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="310" mass="34848" checksum="E586513ABF16E3B3" modified="2018-10-10" version="1">MAQSSRSVEVPMSQRTEAQYTPTHQYNLGSRVLQPPIYANKTFDQLQLNEIRSVSLAAHQFREGEFIPTGFFNKVNPALFKLPAKEVDWSYDKRRTAQQILPCLHLGPWSCLAERGWLNQDGFSLLLAIRDRRLAVARLVSGEKAAADLNILADSVDIQDYQELITALPQTIYRINKHIASSAPSGLSGSTEKKVLVFCETGNGSSVLVVVAYLMVMFDLDAARALQVVQSQRFCTDVSESATQMLLAFEAIIKAKRDVERARRASSMDVTVHSKKRSNDRDIYETGVDEYMALDQDRRPLAPFQDRPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8V6</accession>
    <name>A0A317X8V6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-1,2-mannosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_457643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471382.1">
        <property type="nucleotide sequence ID" value="XM_025607755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8V6"/>
    <dbReference type="STRING" id="1450535.A0A317X8V6"/>
    <dbReference type="GeneID" id="37109898"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF42">
        <property type="entry name" value="PUTATIVE SUBFAMILY (AFU_ORTHOLOGUE AFUA_6G13760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016262707" description="Alpha-1,2-mannosidase" evidence="2">
        <location>
            <begin position="24"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="3">
        <location>
            <begin position="291"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY94621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="86719" checksum="944118883CC4E484" modified="2018-10-10" version="1">MLALKATVTIILASGIATGLVSSNSSFDVLDYIDPLIGTANGGHSFAGATLPFGMAKAVADTLGENQAGFAYDTTYVSGLSHMHDSGTGGVSRLSPSLGNFPIFVHPGCPDDDLDKCTWQQSDRATAWTQESPKARPGYFSITLQNGVRAEMSVTNHSVLYRFTVTNATTQSLSPVVLVDLMDLPQSRTNGTASVDRSTGRLTGNGTFNPSFGIGSYDLHFCIDFKGASVRDTGVWSNNRAGQGQTTISLTSDGSNTAATLSAGTFVRFNAPINQTLLARVGVSFISVDRACSNAENEQPDFDFPGTVSAAEAAWRDRLNVFQIDAGDVSSDLQKVFWSGMYRAMISPQDYTGENPLWQSDEPYYDSYYCIWDSFRGVHQLLTLADPLSQSRMMRSLVDIYRHEGYLPDCRMSLCKGYTQGGSNADVLLSEALLKNVSGIDWTTAYEAVVKDAEIEPANWNVQGRGGLTSWKTLNYIPTDDFDPNGVGLHTRSISRTVEYAYNDFCIAQMAQRLGHQGDYEKYIQRATNWQNMFKDDQTSFLEGIDTNFTGFLQPRYPNGTWGYQDPIFCSALLNFTSCYLNADGHETYEGSSWLYTFFVPQDMATLVTRLGGPETFTSRLSYLHDSGLLYVGDEQAFLTVFQFHYSGRPALSTERAHYYIPSQFNTTVAGIPGNDDGGAMGAFAVLTMMGLFPVHGQDVYLISPPFFEEVSIRNKETGKVATIRNVNFDATYKDIYIQSVKRDGEEWTKNWIAHDFFTGGGVLEIELGSEESDWGTRDEDLPPSMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8Z9</accession>
    <name>A0A317X8Z9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-ketosteroid reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_572844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470139.1">
        <property type="nucleotide sequence ID" value="XM_025614941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8Z9"/>
    <dbReference type="STRING" id="1450535.A0A317X8Z9"/>
    <dbReference type="GeneID" id="37117084"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="436" mass="47969" checksum="A758B45B00F2E5F3" modified="2018-10-10" version="1">MADTTQDNPQNDFYVLVTGANSGVGFDICKRLILDFPLTHPATHHLTIIFTTRSSQKATDTLRRLQTHLPPSSSNTTTTKSTSQITLHPETVDLSNLLSVRALSHRLTTTLPHLDSIILNAGIGGWTGINWPSAIFGVLTDLVHQVTWFTHKVAPTGMVTSPQTTSTNPEPRLGAIFCANVFGHYMLSHNLMPLLHRSTQPGRVIWMSSLEATIQHFNVEDMQGLRTNVPYESSKTLTDILALTADLPSTSPWVEGFYSCSAASGSTDSDTGTREVKETGAPKTYLAHPGICGTGILPLALPLFWAMIAAFWLARMLGSPWHTLSTYAGASAPVWLAVSGQKELDEAEEKYRGHGGGRGSGGFDGGGGMGSWGVVGGAVVEEDRLRRRKRGMRDLTAEEKMEFEELGRKCWRQMEELRVQWEEILEREEREKRVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X953</accession>
    <name>A0A317X953_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_343357</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470219.1">
        <property type="nucleotide sequence ID" value="XM_025607051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X953"/>
    <dbReference type="STRING" id="1450535.A0A317X953"/>
    <dbReference type="GeneID" id="37109194"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="664"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="722"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="762"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="881" mass="97167" checksum="A714399575146521" modified="2018-10-10" version="1">MAISLSQEEDESLPIKGPALDPDVSDHSRQPSRSPHPYRRKGSHSASLPADSGDRSARLHWPRTSSDSGTEADDESTGVLKGLPAAPLRPRKGLRSGRQVAGEEDQWFPVLRPWPSITRSTSRSSRRSSGEEADVEATGLREQAKRKRRIGILQRLLETALLLSVGAVVLGQKDTRSVAWAWRKELLVHSLLVTGLYVAYPFHRDGRFRFSRLRSFVIPTSFDPAPLLYPILIPLYVALSLAQHTPTLILPNIILSLSSLPAAVIPLHGWVHGHSLVHWMITLLPIVVSEHLSAGISPPKYLSLLGLNPESLALVFPLHQALIPTLDFLLTTSVLPAELQLLTSALINLFLFASSPQAEILKALLWLGGLCIFISCRDVLRWEVALARIPSWKFRRAPSNSQSRRSIFNVLDHKLCQRLSRTGTSEDNMSDSDSPEGQFVLVSRKTMFESREKNKAGSPALSAETAGTETVRQSPKFTHRRRHTISSVNEVARTGKIRTTPSGRRKRSMAPGLASFLSMTVPQAQVRKWLYASFVYVIVSLIILGPIRKYVGERALHGEEPFGWALSYLLGNVSWFRFWVIMWNLEYWIPLPARLDPDLSHASCALGWVEHLRQVTFGEASSRLLIAAYCIMVLATGLAVVLQLSSVAEVDTRRKVFHGMMVLMFLPTVYIDPTFCALALSLVLSVFLLLDLFRASQLPPISRPLTYFLAPYVDGRDHRGPVIVSHIFLLIGCSIPLWLSLADIPRTGDHPWVGWNALTRDVGMVSGIICVGMGDAAASLVGRRFGRRKWFWGGGKSLEGSVAFAVAVTGGLIFARGWLVLGQWPVSGPDGQHDGFPWLRVVVKAILAAGGTSATEAILTGCNDNVVVPVVLWLLVRGLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAC8</accession>
    <name>A0A317XAC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="3 5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_532411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="3 5"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470241.1">
        <property type="nucleotide sequence ID" value="XM_025611113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAC8"/>
    <dbReference type="STRING" id="1450535.A0A317XAC8"/>
    <dbReference type="GeneID" id="37113256"/>
    <dbReference type="OrthoDB" id="1659429at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122">
        <property type="entry name" value="APOSPORY-ASSOCIATED PROTEIN C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11122:SF13">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE 1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016020">
        <property type="entry name" value="PHexose_mutarotase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="291"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016020-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="317" mass="34786" checksum="18DF875D03973EF1" modified="2018-10-10" version="1">MDRSNKPSAIGVSAFLPQPTISLRDNTVEATLPTGESVTVHLYGATVTSWKLANGKEQLFVSEKANLDGSKPIRGGIPVVFPVFGPPPSNHATSSLPQHGFARNSNWEFLGKSSSEAFRKEGDDAVKLDFGLSHPMLSEEFQKAWPYQFGLVYSVTLTKGSLATSLQVQNQGEQNFDFQVLMHTYLSVEDITDIRVKNLQTKEYLDKTLNGAAVTETSEAVEINKETDRVYKALDPKVPIVVSTASDDQPLFSITREALTDVVVWNPWIEKAKGMADFGPDEAYKNMICVEAGSVAGWQTLEAGDSWEGGQTIRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBP2</accession>
    <name>A0A317XBP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_530721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472757.1">
        <property type="nucleotide sequence ID" value="XM_025610731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBP2"/>
    <dbReference type="GeneID" id="37112874"/>
    <dbReference type="OrthoDB" id="332863at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050114">
        <property type="entry name" value="UPF0173_UPF0282_UlaG_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF7">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546">
        <property type="entry name" value="UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="96"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="350" mass="38947" checksum="8D0230198517E1A0" modified="2018-10-10" version="1">MATSNTNSKSPCDILTIDPSASQPPTRNHHHPIPTNLPKAKVTKTHPSTLAEENASVYFIGNATTIIQWHGIRIMTDPNFLHAGDHVHLGPGVTSMRRKNPAVDLENLPPVDLVLLSHYHEDHFDRHVEASLRRDLPIVTTPHAKLNLTAKGEDSFTKVTAVDVYNHAIVDIKSDETSRQPRLRVTGMPGKHIPMGKPLEKLNDIVGAIPPTNGWMLELGYSDQSTEFQSGYRIYISGDTLVFDELKEIPRRYGDQAINLMLIHLGGTTVPSPAMLPLAMMVTMDAKQGVELMRLIRPQVTIPVHFDDYDVMASSLEDFQAQVKEAGLDEEVVYLERGDEFRFCVGGERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBS0</accession>
    <name>A0A317XBS0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_562565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472754.1">
        <property type="nucleotide sequence ID" value="XM_025614297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBS0"/>
    <dbReference type="STRING" id="1450535.A0A317XBS0"/>
    <dbReference type="GeneID" id="37116440"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="571"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1055" mass="116214" checksum="836FA861AB6040BB" modified="2018-10-10" version="1">MNVFGTTVDPTSNPLLGGECGKRLIPHVIDATARETPDVECLSVPRTNNPRDGWKPVSWAQVAHAVDYVAHMLLNQAGHPAPGTFPTVAYIGLEDPRYPIFIVGAVKAGYQALFISPRNSVEAQLNLFNKTQCNLLYYDPQYAFAVQPWVNGRPGMKSVPITQWDDWVNAEGVTPFPYTKTFEEAEWDPYVVLHTSGSTGLPKPIIIRQGMLALNDLHRYIPPLNGNRTLMPTWSSFPNPRYLVIFPLFHTAGIMTSSLFAFYYNTPIAFRDPSVPITAENVIDWLQNSNPGWTLMPPSTLEQMSRLPQGVEELKKLHAVGFAGGSIAPAPASHLLSHGIQMVNAIATTEYIFFPYYSQPDSAMFSWFIIPTEMMGIEWRPFGDNAYEQVIIRQNKQHPGQQGCFYTFPEVAEYSTKDLYRPHPTLPDHWTYVGRADDIIVFSTGEKLNPTTIEGAVMGHPGVLGAQVVGTNHFHAALLIEPVQHPQTEAEKQQFVDDIWPIVEKVNAETVAHGRIPREYIFLTDPTRPFPRAGKGTIQRAMVGKVYADDIERIFETSRDVPSTAVHLDLTSLVTFGTGMHTLVQSVVKIPILGMDDDMFSAGVDSLQVIQIARLLRVSLDKAGIKVFIEPRTIYTHPNLTQLAAFVYSLAVSDAAVVADATEACRALVAKYTHSLPPPIPNKPAPSTDGQVIIITGTTGAIGSYLLDAALASPRVRKVICFNRAADGQARQTEASASRGLSTDFTKAEVLQVDLTNPSFGLDSDTYTRLAGEVDRIIHNAWPVNFNLTITSFEPHLRGTRNLVDFSAQARKTIPITFVSSVSTIENWSAPETPIPETALSDWSLAATGYGQSKLASSMILDAAAIESDVPRAIVRVGQVGGPRGQHGQWNPQEWLPSLVRSSVYLGMLPDSLGALGHLGWAPIEDVAAVVLETSAVTIDVPVDERNGYFHALNPTPVDWAGLVPTLREFYGERITRVVSLGEWVDALDKSQSRPEDVERNPAVKLLDTYRAAAKDAGAGFVFATEQTEMCSPTMRRMEPVSPELMRHWCGQWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCJ2</accession>
    <name>A0A317XCJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_529651</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473024.1">
        <property type="nucleotide sequence ID" value="XM_025610493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCJ2"/>
    <dbReference type="STRING" id="1450535.A0A317XCJ2"/>
    <dbReference type="GeneID" id="37112636"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="195"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY96263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="409" mass="47005" checksum="279D68B5FFEE9056" modified="2018-10-10" version="1">MRYLAWVGIPARVFNVGTYRRQGTPQPNATFFDPHNSEGEKMRRAAAEAAVSDMLQWFRSGKGVVAILDATNSTKERRRWIHERCQEDGVETLYVESICDDEDLIMNNILEVKTTSPDYKGQDPEVAALDFRNRIRNYEKAYETIDDNEKNFTYVKLINVGSTVIINQIKDYLSSRLVYYIQNLHIKPRSIWLSRHGESEYNLTGKIGGDSNISERGEAYARALPGLLKKSGVPPNTKIVIWTSTLKRTIQTARHLAAETGFEKLEWKALDELDSGVCDGLTYEQIAQKYPEDFAARDEDKYNYRYRGGESYRDVVIRLEPIIMELERSENVIIVTHQAVLRCIYAYFLNTPQEQSPWMEVPLHTLIKLTPRAYGTDEQRFKADIPAVSTWRAKGTSAKHQEYPTEIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCV3</accession>
    <name>A0A317XCV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_580733</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472303.1">
        <property type="nucleotide sequence ID" value="XM_025615348.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XCV3"/>
    <dbReference type="GeneID" id="37117491"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000015">
        <property type="entry name" value="IQ and HECT domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="1016"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY95542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1392" mass="158683" checksum="F84AC7B7F41FA1FC" modified="2018-10-10" version="1">MFKPSQPMMARLRLTTKQINGGYYKGNRTGSMGYFAKNGSYVIDWKKVRTYVVPENLDQFKLTPFVTKRMPPTKSKYTNEVERRGRTMTIERAFGGKDYLDMWASDNGQEVLEQERLESEAAEKAAEKSNSTKPTQYLCIVACPSHLSDRVLSTDFQPQRDPDATMFQSFTGNSRRPRQVNLGGRNTNPFAAYPSGRQNPHGAGPQNTLAIAQQERLVRQQERERLTSSRLIQRTWRGYRSRKITRRTWRTEWDTTERQGNEDSLSFEALAQRPDVVLQQCLRYGTATECLSQLRLLVQFLEPWNSGDVARLVYFSEAFQRTLREVPTIATEGEWTTPLKRLANLTLRVLRSAMSSTVPVFAVGHLLRLLVFLMGLIPKQMARLAKSYYSVMAMFTKDFGSMSQRYQLSQDGLVQCVLALLRPITSETLTAYEWFARSYLTIPNLLEYIGSLDGISNNINYKLLTSALGSLRTLLEDYPRSSEDVDARLWLLAYFIFFHRCALGNQTGRQAPEPGFVKVVSKLLNSTAVHVSRRLESEDSNEYDDTPERTPLHPFVKDQLVSLVNQSSITGLLSRLQSTRLSQGDLADAQSDASREAKVLATYALTLLRVFPRRGDDIRMWLYLGSATSGDQTAGQSGSRIPAIKYFWQASRASKIFAAISHDSTKVLPLLKPAQDAQGASPGISQFDRDEEWTIILLFLELYTFVLKVMDDEEFFSSESSFTASSNARVSWTKESALPLRDIREMTVFLKNLGFTLYWNSADLSEKEITQDTGGIRSYFNSTTAPSDTIASVRDIEMKNKEKGLPGVTGIPLDYFKGLVTGLLRMIHERDSRRKFLPDGHWLMTSRFDMEGFIPAVTAEEENRHQLQDEDNKEEHDDLIHDDYYEPSPGLIGTGRAQQTLRIEALRRRQQQAARRKQLEAVAPRLEILRNMPFFIPFPTRVQIFREFIYRDQMRRRQGYIEPDSWRISVAQVPMGRMIDGRPAVVDILSRHHANIRRESIFKDAFDEFYELGVGLKEPIQITFIDKFNTPEAGIDGGGVTKEFLTSVTSEAFKSTNDTNLFEENDQHLLYPNPVAVEQRREFLRQLGFVENTPEWNENIRDLLRRYEFLGRIIGKCMYEGILVDVNFAPFFLLKWALTGGTGSAQRETAYRANLNDLQDLDQGLYQGLLQLKNYTGDVEDFSLNFTITDTVPLPDGGSRTTTRDLKSHGSDIPVTNQNRLVYISYIARYRLQVQPALQTNAFLQGLGQIIQPSWLSMFNQTELQTLVSGDSGDIDVADLRRNTLYGGVYTIGDDKEEHPTIKLFWEVMEKMSNAERQKVLRFVTSTPRAPLLGFSHLNPRFSIRDSSEDQERLPSTSTCVNLLKLPRYTNADTLREKLLYAVNSGAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDX2</accession>
    <name>A0A317XDX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_619639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473286.1">
        <property type="nucleotide sequence ID" value="XM_025616877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDX2"/>
    <dbReference type="STRING" id="1450535.A0A317XDX2"/>
    <dbReference type="GeneID" id="37119020"/>
    <dbReference type="OrthoDB" id="4507172at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="111" mass="12156" checksum="53A3BC2262A5F805" modified="2018-10-10" version="1">MSYRSSSYTTTSTSYSSSNNTTTNNNNNNPTSNTSNTFSTQNTTSTPSSTHPQTTGHRYASTSHTNPSGETTTRSGYQNLGDDPIFQERRVDGAGREDLEMDEGDVDDFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDZ4</accession>
    <name>A0A317XDZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">OPT superfamily oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_531693</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471521.1">
        <property type="nucleotide sequence ID" value="XM_025610954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDZ4"/>
    <dbReference type="STRING" id="1450535.A0A317XDZ4"/>
    <dbReference type="GeneID" id="37113097"/>
    <dbReference type="OrthoDB" id="627262at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="591"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="806" mass="85164" checksum="DCF23ED015F2676C" modified="2018-10-10" version="1">MAGHASDGDRQQDEPARDGSSPRSSVDHDGRTAYAHISQPSATSPQSFTSRSLLVGLLIGALITFSNTYFGLQTGWISTMAMPSALIGFSVFKVLSKHLSYPFTPIENVLIQTVAGAVGTMPLGCGFVGVIPALEFLIKDGEDGPSGDGGTGEGGPLKLNFWKLVVWSLGVCLFGVVFAVPLRKEVIVREKLKFPSGTASALMLRVLHGSGQGDEKAKARAGDVEGVPQREEVYEEPALAHEPGESGPLLKKTDSSHLDNDQKDWRSKMRLLVGAFAVSGFYTLFSYFVPQVRDIPILGLYLAKNWLWTLNPSPAYVGQGIIMGPSTCMHMLFGAFLGWGILSPLAKARGWAPGPVDSWEDGSKAWIVWISLAIMLADSLVSLGWLVVRPLVPRASKMKDKLLRSRAGQRVISGGSASSNLHLYITYSALSPITEESSIPSHAVPSIGRRSANDNDDDDEDAPPSQLISTRTVIILLPLTLILNVVCMHIVFGDIMSPLLSSLATFLAVLLSIMGVRALGETDLNPVSGISKLTQLLFSLATPASHFSRRTALVTNLLAGAVSESGALQAGDMMQDLKTGHLLGASPKAQFYGQIIGSLVGAVLSTAVYKMYVSVYEVPGPMFQTPTAYVWIFTARLVTGQGLPPMAWQASLIAGIIFVAITILRLVAASPIANGGRKDVSAPWRDWIPGGIAVAVGIFNVPSFTLARAIGGLIAWWWSQRHAAKSAAAASDSAAATGDVDVQTNLSESWTAAQAGGTPAPGQAIKEANADAASSTVVVLASGLILGEGIISIVNLLLASGGVPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGN0</accession>
    <name>A0A317XGN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_530781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472861.1">
        <property type="nucleotide sequence ID" value="XM_025610748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGN0"/>
    <dbReference type="STRING" id="1450535.A0A317XGN0"/>
    <dbReference type="GeneID" id="37112891"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="116" mass="12683" checksum="1FA2029F2DF6F5A7" modified="2018-10-10" version="1">MSSSLFTEPSSTFQATHSFQNRVRSRMPIVLPLVGFMLAYPYCHRCPRARRYIRLALEIFDSAGSNSAATVRAAALTGHLSAKVDTLLRILNIDDSLVPMRNSQGGGRSTTIAAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UUY8</accession>
    <name>A0A317UUY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_579913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000060">
        <property type="protein sequence ID" value="PWY65261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461386.1">
        <property type="nucleotide sequence ID" value="XM_025615293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UUY8"/>
    <dbReference type="STRING" id="1450535.A0A317UUY8"/>
    <dbReference type="GeneID" id="37117436"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="547"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="684"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="689"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="712"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="750"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY65261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="809" mass="90637" checksum="F42AF75636E7C763" modified="2018-10-10" version="1">MNWLIVRAARELTLEAAQSAAMSRGTSTGLSNRNLTTSHIKKLLDSRNDREVLDGMRRVITLMYRSEPSLPFFSAVVKNVASANLEVKKLVYIYLVHHAEVEPDLALLSINAIQKSLTDQNPHARAMALRTMSGIRVPVISQIVSLAIKRGCGDMSPHVRKAAALAIPKCYRLDPNTLPQLIGYLTILLGDTQYFVLGPTVAAFLDVCPDRIDLIHKHYRSLVKKLVDMDEWSQLSTLRLLTFYSRKCFPLKTQKGKQAVSEGFYEDDEAPESSGDGNAHEMLVLDPDLEFFLRTCKLLLQNRNSAVIVSVVRCFLYLGTPEYLDAAIGPLVALLRSPQDTQHVALYNIVAVALKHPKPFTKYATHFLVHAVDPPHIWRLKLEVLTLIFPHCGLHLKGVILSELEHFSQSADPDLVRESVRAIGRCAQSDPRTADHCLCVLLGQITSLDDNLVAESLTVVRHLIQQDPPSHEKTVIQLVKHLGLMKNPDARATIVWLVGEFAGVEPERNIAADILRILVQDFANESEAVKQQIILLGAKVYLHHLLRNPPKEAPPPEPKPERIINEWTETEEDQKEETGDEEKPSEEPEEDQMTLLWRYLLLLARYDSSYDLRDRARLYKALLASPSSTQLANLLLLAPKPVPHAPSPSETRKDLLVGSSTLVVGPDAGMLGLKGYQNIPDWVESGQEPDPRLRENEIKPDFAEKSSMTAGKRLDRALKDHETSVATSSRQQNGRVGAGGSSSKGKSLDEWLEEAETETEEETETEEEVTDSEYEEVTDEEETDEEEETDEEYETDSEEHEQTMGLLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXY5</accession>
    <name>A0A317UXY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-1,6-mannosyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_339494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000058">
        <property type="protein sequence ID" value="PWY65372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461438.1">
        <property type="nucleotide sequence ID" value="XM_025607027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXY5"/>
    <dbReference type="STRING" id="1450535.A0A317UXY5"/>
    <dbReference type="GeneID" id="37109170"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306:SF5">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31306">
        <property type="entry name" value="ALPHA-1,6-MANNOSYLTRANSFERASE MNN11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY65372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="461" mass="53444" checksum="E9FB661DB658AF16" modified="2018-10-10" version="1">MSLSRSPSPHPAGAGWSSPGLTPGSGTSTPHSGFLTPNPIGASGISWAAAKAKSDEVRGYPSFSTRNSGFFSRSRRQLSATLPRFRLGSGSPNGYVDKDEFGRGPQVSPAGGWRLGFGRTLPRRRRSRLLLVLIFCLLGYLFFGASIVQKYRRSPLGGGRKFVIILESNIEGGVMEWKGAREWAIERNSVWNKNHYAEQWGYEVEVVNMLAKKRYSHEWRESWEKVDLIRETMRKHPEAEWFWWLDLNTWIMEYSYSLQEHLFNRLDEIIYRDINVYNPLNISHPPTDAYLDEVSRSPNGDGDASSVHLLLSQDCGGFNLGSFFIKRSLWSDRLLDSWWDPVMYEQKHMEWEHKEQDALEYLYATQPWVRNQVGFLPQRYINSFPQGACGDENDPNVHYQEDERDFLVNMAGCQYGRDCWGEMYQYREYSNQLNRSWWERLKEKLNGVYERVLPGEEQQVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYQ0</accession>
    <name>A0A317UYQ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_561523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000057">
        <property type="protein sequence ID" value="PWY65622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461458.1">
        <property type="nucleotide sequence ID" value="XM_025614225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYQ0"/>
    <dbReference type="STRING" id="1450535.A0A317UYQ0"/>
    <dbReference type="GeneID" id="37116368"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="23"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY65622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="575" mass="64093" checksum="87EEAEE697B30575" modified="2018-10-10" version="1">MKAPYQWALFATSTLKNLETASPTVTISSPSATIIGELDNKDVKNVEVFKGIPFAEPPVPSNALRLKPPQPITTSLGTVQATGYPAACPQMDVRETKCMPLPPNIAALMGPTGPNPEVIDEDCLTLNIWRPKDSTPDKKYPVLFWIYGGSFEVGSNMDLPGGPIVEASINQDLPIIFVSANYRLGGFGFLPGQRVRDDESANLGLQDQRLALQWVADNIHNFGGDPSKVTIWGQSAGSHSVFHQMALYNGDHTYHGSPLFQGGIMNSGNTWPVDDVNGTRGEQVYKHVVENSPCSPGNDSLACLRDLKYPDFLRAVNSVPSRSGHFSLSLSYLPRPDGKVVTASPEEAVLNGTYAKVPFIVGDPEDDGSAVVMNMTNITTTDHVTDYLWGYYYRNAERSQIKELVSIYADDYEYGAPFHTPPSNSLYPQSKRLAAILGDFTVLLTRRFILADAVPDRRNVPSWSFIFSAFKGIPYLGSFHGSELYMREIWKMLQRDFPDLFPGDIEPAIASMWSYYFSFIYYQDPNKANQTLKWPQWTDNQQIMNFTRNGNEIKPDTFRYKATEFLVNNVESLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V350</accession>
    <name>A0A317V350_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_570044</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461876.1">
        <property type="nucleotide sequence ID" value="XM_025614773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V350"/>
    <dbReference type="STRING" id="1450535.A0A317V350"/>
    <dbReference type="GeneID" id="37116916"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="159"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="384"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="539"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY67232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="584" mass="65605" checksum="1C5D9B7EA6C4309A" modified="2018-10-10" version="1">MERFDVSDMSNALNESTANEPKLPNEAASAAREKGWTTPEQYDYEKYNATVAPLGPSQNGGEENLPAWAAQAAKYEWRDDYGDVGPRNPALEEQLYRGEYINRTGLKIGNLQNIEVIAESRERPSPVKSFDEAGLHPIIRENIRLCRYEVPTPIQAYTIPAVLTGHDLIAISQTGSGKTAAFLIPVLSQLMGKAKKLAAPRPNVADGYDRMLHRVTAEPLVLIVAPTRELSTQIFDEARRLCYRSMLRPCVVYGGAPSREQREDLEKGCDILIATPGRLLDFMNQNKVLSLRRVKYTIIDEADEMLLSDWETEFQRIMSGGDVNEDADHRYMMFSATFDKGCREMARRFLAADHVRVRIGRPGSTHLNVDQNIIYVEPGMKNRCLYDLIIAMPPSRTLIFVNSKSQADFVDDYLYNNKLPSTSIHSDRNQIEREDALRAFRTARCPILVATGVSARGLDIKNVMHVINYDLPRVQHGGITEYVHRIGRTARIGNEGLATSFYNHDHDSDLAPELVKLLMETKQTIPDFLESYIPEDKVVKFDDDTDDENEKNDNTGGDTDASWGGMPMDSGDAPPVAPDANWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4S4</accession>
    <name>A0A317V4S4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_628582</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462291.1">
        <property type="nucleotide sequence ID" value="XM_025617489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4S4"/>
    <dbReference type="STRING" id="1450535.A0A317V4S4"/>
    <dbReference type="GeneID" id="37119632"/>
    <dbReference type="OrthoDB" id="4060227at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="25"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY68976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="642" mass="71592" checksum="FF82F1F5BCC2C5EF" modified="2018-10-10" version="1">MTRKRQRTSHPPNEIQGLRLTRSKACTECKTQKTKCETNHGETSCSRCLRHGLECVSYDVSQQFLQSDMAWKNQTTEEVGLLRAAVQHLLRHTQQPELSSFASQTSPSGRSDARVEHQDAAIDMSRENSPQPQENGPTGLITAPMRSLYELTRLKTLRNNPAWKPRTPLIDEDFISQGVVSVEEADFLFNQFVDSNNRMLWDGALLLHRTLDSVRRSSSLLTAVIFTVGALHTPGRTEAFHQSYNVFVSLASSLSLSRHHSLDDIRALCIGAFYLANLSWKLSGQAIRIAAEIGLHQSYHRLMQGERNQMEHVRLWYATYVCDHQFSIAHGRPPAAVNDESIRNIELFLSQEGANNGDARLAAQVSLFATLTEAYMAFGSDPNRPLDQQDIEKLRVFNVAVEQWKLQWVPRSENCVILGSYPSKALVLYYHFARFQLNSLALRGVAPPGPVPTDLSLGHREAANKAIAAAMATLTLILEEIDLRLAFPNVPIFTYTMVAFCATFLLKMAATWGRDTAGEVGDGSNRLGLMIDTRYIVSLVQQSADMLAGVAASLNEKHLAKHIAAGMLEMLQQFHSLDKEARNTFAPVPDLNTMPTVQGMPDETAFWAGEYNFHDLGGTFGFGLDETLLGQMAADNFELWPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V571</accession>
    <name>A0A317V571_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_540006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462361.1">
        <property type="nucleotide sequence ID" value="XM_025612821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V571"/>
    <dbReference type="GeneID" id="37114964"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY69156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="69" mass="7712" checksum="FE6969D97A676B50" modified="2018-10-10" version="1">MISAVVGWIRDELDIQTQLGVSACKSMEKRGRSELLKANTNSILVRLHDGAALPHDQLLTIKLRPQLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7U0</accession>
    <name>A0A317V7U0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_611392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462352.1">
        <property type="nucleotide sequence ID" value="XM_025616630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7U0"/>
    <dbReference type="GeneID" id="37118773"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY69037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="299" mass="34841" checksum="F843B73C79173D7C" modified="2018-10-10" version="1">MDTVQKTSQYESDITKLLDKAGIPNCIWGEGILQLMGAGEQFNRFSWVIPDEEIHKASKALSDAKYTRQNRSRSPGESMGDCVYLYPSDHMIEVHLFAKSRLCWTFPDLPREAPQPDDEFYILTSQVQRLEDNVPCVRDYPSKESHPVRMPRPEKFLEALVLLCFRDLILQEFFDPWKKQLRMIAKHLFKGFRCCGLHPVFADYLIRFSIRIGSEDRKNQSLPDPDLHLMYVCLTRLGQLPLPEKDVPRDAWPGEQDIRKRFRKVNKALDVCSYDGPAQGTVMWTHQEVVMTLESEMWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8N2</accession>
    <name>A0A317V8N2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tricorn protease N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_539993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462489.1">
        <property type="nucleotide sequence ID" value="XM_025612815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8N2"/>
    <dbReference type="STRING" id="1450535.A0A317V8N2"/>
    <dbReference type="GeneID" id="37114958"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32161:SF8">
        <property type="entry name" value="DPP6 N-TERMINAL DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY69661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="618" mass="69114" checksum="CA00AE2ACD18F7DF" modified="2018-10-10" version="1">MNRIGPSGSQLWISNSDGTNATKLMGNQTNAFDYHPSWSPDGQWIVFTSERRGPGQSDLYRVHPDGTGLEVLADTNSVEDIGVLSPNGNKLAYVSTAGNYTTNIWVKDLTTGLANNLTDTASTRADNIYPTGHFRPSWSPDGEWIVFSSDRNTDWTGHSEGVGWEHTQTLGLYAIRPNGSDFHTVIRQSGYSLGTPQWSPNGKRIIYNNMTTEDTYGCHGVSAQQEAIEAQIYSVDFATSSNVIAHTSGSYPKVGQHYIGNSTNIGYLIKAGDYEGIHYTQPDATHHAFNLTYLRDPSWSPDGSKLVYWIPNWTQQAADLELWSYDTDWEYRYMDVFPMHNTVVNRLATTQKVLGSANGSLVHSSPTYTDVVDALDSYDIYSLNNSTEVVWLEEGNSGAFQPSWNPDGTELVSGFGAWFVSRTEAEARIWHAFANGTYHTNLTDGTDNSGFPSYSPDGSAIVYRKWSLETGVPQGLHILNFTTGQTHQLTSGWDNTPGWSPNGERIVFTRNNNWTESYGARWYADRFDIYTIRPDGSELNRVTDSLSNDAHAVWSKDGRIMWSTGMYGFKDESALFDNTFQPYGQIMVMNYDGTNKTLVTDTIWEDSMPLYMPNEYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9F8</accession>
    <name>A0A317V9F8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_477663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462496.1">
        <property type="nucleotide sequence ID" value="XM_025608651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9F8"/>
    <dbReference type="GeneID" id="37110794"/>
    <dbReference type="OrthoDB" id="2105912at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY69668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="394" mass="44816" checksum="5B3974875D132D28" modified="2018-10-10" version="1">MGRPNDLPPSYEEAVASDPASRAPAFPAPPTDTAAPPIPNNRPYHSVRSDSEESETVNISPALSQDATALHAHIARQVEIPPRPYLTVRGSHTETRHDHNRKEDRKETVEDFTFKVDLSGYLIRDEHPPQHYDDDDIGLQLAPDSQDGWHVVTLVRDNDGQQAYRGGRCKSDTWTGHEQRPRSEPVQLEDGPNNETAGLVREHEDGPSLMGWCERYCEDPAPVKSFAFGRSVVGFDSSVLHSALTSHLRSLHYKGDISITTNLANQELFVYSPHWVNQLRNNGFVYWFCIILQLWIITWPVIWFLERRYDVVRSVWYFSRVQGGETQYACHRSEAAIADELAPAVTQAALERRLDGKILTPQEMELLDRLGKERQQRGVVVMQWDRFLGWGNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9V3</accession>
    <name>A0A317V9V3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_609121</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462739.1">
        <property type="nucleotide sequence ID" value="XM_025616569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9V3"/>
    <dbReference type="STRING" id="1450535.A0A317V9V3"/>
    <dbReference type="GeneID" id="37118712"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016248202" description="chitinase" evidence="12">
        <location>
            <begin position="27"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="335"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="13">
        <location>
            <begin position="399"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="544"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY70845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="943" mass="100285" checksum="5F554DEEFAD83DE5" modified="2018-10-10" version="1" fragment="single">MRWASGVASALLGTLAYHAAPGLALAEVDPAEVASSVSAYLAAHPISTRHATQTPDPSSLMAAVLAGNYTSRLSNTTRSRCPVSCSSSGLNSTAWSVYHSVDRLGLCGSPMLLDFNLFNQLDDAATHVSIAACTADFKSVSSSSLSTRDTSDDSSCIAQSVSRSTVTASVQLASSGNASSTGATDVVDALEQLQSTFTLSGSDCNEVIRVAYAGQAAVGVYVGSGLSGQGVMSSVLNQLVTEIDSNGSIAQETLVQVCDNSTSRYSLGIFASTTGNLLSVQRALQSWHNSSCVTFMEESMPAWQTISYLAPSMQQNSSVPSNYTSLAAREHDECTTIQVASGDTCTTLATECGISGADFDDYNPSSDLCSTLTVGQHVCCTSGTLPNFAPSEDSNGDCYSYTVQTGDTCTALAAAYDITVDEIEAWNTGSNGTWGWMGCSDLLVGSYMCLSSGWPPMPANVPNAVCGPQVNGTSTAPHGTDLSTLNECPLNACCDIWGQCGITADFCTQSNSTTGNPGTAAKGENGCISNCGTEIIVSDAPSETYSIAYFEASDQTRPCLTMSVDQINTTFYTHIHFAFATINTDWTINVTGLEDQLSLMSNMTGVKRILSIGGWDFSTDADSYMIFREAVTEANRDTLLTNVVDFLEEWDLDGVDFDWEYPDEPDIPGIPAGTTADSTNYYLTLAVLKATMPVGKTVSITAPASFWYLERFPIEAISSAVDYIVYMTYDLHGQWDYGNAYADSGCSDGNCLRSHVNLTETLSSLSMITKAGVSSNKVAVGVASYARSFEMTEAGCWTDMCTYTGPDSGAWPGPCTQTAGYISNYELELVLAENPSAEVYWDNSSYTNIMVYNETQWAGYMNDTNKAVRTVLYEGLNFLGTSDWAVDLQSEDGNEDTGGSGVIYIDPIIFNEPSPTVAGYPPFTMVWPTSTLATPSVVHFPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VAE4</accession>
    <name>A0A317VAE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_269443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462620.1">
        <property type="nucleotide sequence ID" value="XM_025606548.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VAE4"/>
    <dbReference type="GeneID" id="37108691"/>
    <dbReference type="OrthoDB" id="2582433at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12526:SF630">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="859"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="895"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="926"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="962"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1269"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1298"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1321"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1665"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2753"/>
            <end position="2773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2794"/>
            <end position="2837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2762"/>
            <end position="2773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY70329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2876" mass="321988" checksum="4F2EE66526F348BE" modified="2018-10-10" version="1">MAKILDVSPVGWIYMREYWWQFVLIAILLASVVCGCSYFTYSGTRRAIRWYKSRPRVETIPVTVLQRLDKLATQQLALATHRTKQKPSSVGVYLGSLSTPSDATHRQLLDSYDLLIVDPSKSGVVQAISHANGKQFMGRVDLALVPAQDSTLAAIEKIDSFLAGSFHGAAFCGILLANWEDKFTPTVLVKLAEAIHGLGLAVYLETAPPTFLTDGQILQSPAISGLVIRNASILPDGQKRDYFQLNDLRPTIKAFVSEACMREFSVIAWETVDDDAYLSNAVVQRSMGWCNFYSAIPWIGRQSALENAALNVKTPEPLSSFGWLKDAEIMKVHDRWRTNLHIARDSDTKDSWDALMPFFPSLENVLTSSEYPSRSNRTPTTTLREPPEWVAQVKSQGSPLSISMASVEYKELGCFPLGSEATPAAFAEIVQSQLRLKSLSLLHPVPVSKLQSIGLLLRQFHDNLALSSWIPSDQLAASIKELSNIASNDMLNVYLGLDSGLRKSTDVRFWAVYQMDTDGFDIFASKNAQGLVGTVLHTFLSAKGYPRHVCFEAETALARWSKDFNEDIGLSRRVVQDIDVLSPEERLLLLQHLSLTDAKSELSETICAYLRRQLVDAPTLAQLKNLNTVSYLEGSTSPAQLIETRINWYKEQGCQYPSAASCLALFNEAESVFTEVLRERKEDDLARISSGLCELIQDGPVDTYTDMMLLSLFCAARKGALDEIYAEVTDRNPLFNSQSDQAAAFAESFALGSRCEAYFDILPSAFGKLLSDRFRKSYTDEQLPNWINGAPDMATSYAGAQIDVNPAHKVKPMRGYQRFTFLSVFAFPALIDIIMLTIIGRGLYLSAFMTYDEQQSATIALMISLLLSGAIGTWIACGGPYYLISMAFAAANMFVLIRLIAGIAFTVAGGLIGFICISAVDGPRSGIIFYLYLIALTIYFSAFASLASFSYPGSTFLSGRKIIFACVPILFISPIVTTFAGHDSAIYLAVIYVFIIALLFGLRSVASKWVTWYQSIRRTDDTEIRKWYVATYGNNDEKVFGNLSDPAVLKLSREALLKDVMAETQRWFFRKPTTDKLVLELAKDWDATNFLLDWYCRYADVPRPIPFSSSWNIQTKVGLDVLRNSQKGIRLHNAFIQWRQSSREIGCGVLYFILALLDKWVELLTGGHLVGLSASVTSSQRMAVGFGLAYYLIGAVLIDTKAQELHDLIGKQTSVAVHKAKDIRLVQKRDVRYKRKVYWRTFFKFLMWHVWSLALSTALLWTFQNTMEAMIIYCSYILAYTGLLWYQYTKIFTGPHAFKTLLIGCLVGLPVGIALKVRLPHFLYSEVIGLGSATWTVAILTLFSAKMGMPKNVASPVELGKVFHAYTAPWADPEWSQQELQTFYEKISLVPSDARLNLTPQAHPGVEVKEILLSRRREPRIEEAFPKSEDLVNLALGAWAKGEISLELVPIGSLGPGVHALSCSTTGQLHIAICVGRGLDQRIDVSANCQVIAETLLHAVAESMLRMPHEYAVLAESLVTAGVTETMARQLRAESNTAGVIRWAKTELLQQLCLGFECDAHWEKLPKDIRTALINRCLGQPCELSEASRKWLEESLCRFDTDVLDVHVARSNLGAASAVSILDYAHYGTGEAAVFRDPETPEHIPYVPRKLPAIMQVLVKPWNSLYYALASIIKFIVVALVADPEFQREFNHVIRQHHTIIRVPATLALSLLWSYSRIMQNLGLSFFLFHGRDNVKQLWNETKGMTISIKKSRFIIQSLDGTFTAFKHDEPDGGFKVYYYAGQHKVEPEGTKSLSYVCVYSKDVLLLVRQEFKAGKLLNEYHYDYRAPTKKTFGLSKSSQAKIPMGRRCVRGDNHLQSVQYNRKGLIEAGSFMKDGNLIRFKYHYRKNPRFGDELLRAEFALSHITCTVSWCAPPLRHPEKVDRWIPHSKVTEATFVQGADVYEARWLYDHKFHPTIFTTLNGQKVQTPPMIEHDYLAVLAKPKYTSFVHDNPLVYCDSLNSSVFTRFFGLTKKRFPVSTSRARSLIWKAWKDRVDFDGVIVRWMDERLLRRDKTLAPYWRSRDCGDLASAKKYLDIRADTVTASADLDDNISSWTPLAVKISDLFNFGPGGDAVVNTRSKDFGADTEKSLHVMAADNGTWPNEGGGVSACRRDMINSLRTIKWHMICESANDFGIPKHQTEQNILSLKVVPLWGLDFLTPTHGLFTNKLDSEVENVTSASEMDIKMNFIPILTALVKGARAVHLSKADIQQATRALVNLNTYFQDSRHWTQVWDSEIVKESWRDLWLSQEMANAVPSSEWFHTELPTLASLDIALELWYRYLFIFSIPIPEKIPNVFQASHHSVSASYGVVCKMKRNCTLQIWDHAISWRETNLCLSSALCKLSPFVRNTLLGLMRVTSVLTLHHADIILPCADFFNPGWEVEIGTCQGTIEHRNVFRRKVDPVVNGITDMQKFAPVKEIKSERPTVTMLSHVWYAKDIKIALLAADIIINQWKFDDYHLDIYGAIDKAPTYSTECQEIIASKGLRGKVTLRGTADPMKVLENTWLFLNSSLSEGLPLALGEAALTGAPVVCTDVGASLRVLSDPDDFSRFSAVVAPNDALALARAQITMLGLLGEWSKYAEDTEAPPVLTSSPTPEDVAKITRRMYEKSEHRRKLGMMTRNIVQKSFSGDRYLREHEQMLWIGKSARTMASRPNGNLNEPLDVATALQQTLPIDEEVITIPRSAVNSWRSSAGSGMSTLYSSVSNFPMLNSHQRPSSIRSSVSNASTDASSFMPLPSSASLPVFAPRQTLSFSGMPGSKSPTGHLSPSGRLSPVLSRTGRHSRTHSLSTAGREQLRGLQREDLHQYRNSDVSMIMREEFLQSSIFRGIEGGNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCV1</accession>
    <name>A0A317VCV1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_252227</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463147.1">
        <property type="nucleotide sequence ID" value="XM_025606441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCV1"/>
    <dbReference type="STRING" id="1450535.A0A317VCV1"/>
    <dbReference type="GeneID" id="37108584"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000211">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="49"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="299"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="565"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="523"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY72194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="629" mass="69423" checksum="2B05631DDD1ED712" modified="2018-10-10" version="1">MASINAIGVDKSQDDEHEHMHEEPVEDDEEDGADMDPAFQEYLERQRMLDEFLSPIALDEAVLYKLARRFSVVYRDLALHSKEQFLPTPVTRLPTGLETGRYLAIDVGGTNLRVAFIELLGEATESDVRSTDASERSRDTIRKAQRQRVRRTLERAWPIQEHLKMDKAEDLFSWIGDCIAEVVAESLTSEATRGHIPEELEMGITFSFPIMQESLTEATLMPMGKGFAITSDLDLRKILLSGYEKHTRRPDNEFEPSSKRRKLFELPKLKIAAITNDTVATLASLAYAVKSLPNSRVAMGMIVGTGCNATIPMKLGMLHDSKAKHVKSKDPQAEETVVNTEWTIAGAALPLRELNIITKWDIELDRACVRPGFQPFEYLTGGRYIGELIRLVLYDYLTNVSKLSRRVLPAMLIQEYALTTTFVSDKVARSRSDQELADELSRSLPPPENSEWGWDAVSAAVFRKIARTVQRRSAGLIAAAVVGLLACAQEIELKVDSHEGSPQNPNVSLPEYNGTPDLFAVSKSLSPSTLGPEGANSSDSRSGHGPIVPVLSPTPTPADWQSGPEELVVAYTGGIIQHYPNFKETCQQYIDRLIMRTGPQKSGKSVFLREASDGGVIGAGVLAGMVGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDY9</accession>
    <name>A0A317VDY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_476768</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462887.1">
        <property type="nucleotide sequence ID" value="XM_025608613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDY9"/>
    <dbReference type="STRING" id="1450535.A0A317VDY9"/>
    <dbReference type="GeneID" id="37110756"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF57">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY71132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="647" mass="72970" checksum="EB735DB3E8F162C2" modified="2018-10-10" version="1">MDRPGRYNVERSCLRCHQRKIRCNKGSPCGSCVRANTACQYPGPNRVKRRASKITHADVMARLESLERSISALLGDRSHHVNREANRTKSPAPAAESPPSNAVSPTDITDQSAHDGLLVDDGRYINEQLLSRVLENEKDLQSATNTPRSDEIGFRRPPALKAEGLLINLFVEVGDLQSLHPGQWQATQLWQDFLNHIDPVIKLLHAPSTQPRIFAAINRPQDAPSDLHALLFAIYLAAATRMLAEDPTNEQKALEACRYQKGLELALYHSNFFESPTLTSLQAISIYQTCLRYYNSGRAGWTLRGLVIRAAQSIGIHRDGKHFKLTPLECELRRRLWWHLCSADSRAVEDHGVGVTGGREFSDTAFPANIDDQNLSATATVPPESQACWTEMTLSLITTIANQKRLELHCALTSNVPKKRPAEIVQDVKTHIHDTYMRHGDPNIPIQRYGMLLGEILVLKMEMYVHQKTLQTQSTAVPVTERREMQARTLDVACQALEQTNELFTDELLRGYRWLSSTYMPYFILTYMLWHLCVYPMGLHVERAWRGVNLVFEMTKDPSWPSPGPKWAIITRLRDKALHIRRTQMAAEQATQSVETPAIGADQGGSAVESFFDFVNWDMGMIGFPDWTGLTQSVDITGFEHLLDSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VF09</accession>
    <name>A0A317VF09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_245233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463249.1">
        <property type="nucleotide sequence ID" value="XM_025606400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VF09"/>
    <dbReference type="GeneID" id="37108543"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF7">
        <property type="entry name" value="PA-PHOSPHATASE RELATED-FAMILY PROTEIN DDB_G0268928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="157"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="235"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="353"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY72475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="447" mass="50075" checksum="16CFF713ED921E31" modified="2018-10-10" version="1">MGVGAVLEPLTVIVLLFGGTWINRTIGSSPARRGRRKSIVTSRGTSPDAIESGVATPTAKDGLLPRRLSSSSSLPQVGQTRWRKRQVGIFSSIFEVTSPDTTVFHDRLLSRLLRKFPFLVECWYWALVYWTYQLGRAFTAVTLQEGTVDVARKHALQLIQVEEALGLFWEVPIQRFFLRHARLMTWTNWIYSFIHIPGTIAFLVWLYYFTTTRNRFDESQPGKPHGFMSGSPAGPRLYQARRRTLAVCNLLAFVVFTLWPCMPPRLLSDKDAQGPDAALGRSYGFVDTVHGVNGAGSVWTENRFCNQYAAMPSLHFGYSLMIGLTIMTIPLPPHQRRRSRVTIGSVGLQIPSWRRLVCLVVGLSYPLVILAAIVATANHFILDAVAGATVCALGWKFNGILLNLLPLEDYFLWALRIHKPVPTELDEVEGADGWIDDGLPEHTALPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VG70</accession>
    <name>A0A317VG70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_569484</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462734.1">
        <property type="nucleotide sequence ID" value="XM_025614739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VG70"/>
    <dbReference type="STRING" id="1450535.A0A317VG70"/>
    <dbReference type="GeneID" id="37116882"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY70840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="508" mass="58862" checksum="71F86264B0518010" modified="2018-10-10" version="1">MGFSLLLLVGLGVGIFQIPKIFYRLYFHPLRHIPGPRLAAITHLYDFYYNVYHEGKLIFQIEELHKIYGPIIRIAPDEVHISDPTFYDEIYASSRRRRDKPGYYIPLTGFPQSLVSTTTHDHHRMRRAVVSPFFSRRSIQELSVVSEGCTLKLMDRLQKFHDEDKIVRLDDAFAAMASDIITYLCYGYSQGFLGSENFGSYIRRAVNETTTASHLNRLFPLLPLLMRMIPMRFMCFFRPGLGIMYTYLKKLYELSAQALPTNDMDVNNTGTKRAKYKTILAKLGDPRIPPQERTLDRFRDEGVQFLSAGTETTGSTLTFAAYILATHPDVLQRLRTELKQILPTPISTSTWMDLEKLPYLTAFIYETLRLSYGPIFRAGRIAPTETLRYNDYVLPPGTIMCSSTYFIHRDPILFPDCDKFDPERWLQGEKSDYLKRYHVSFSKGSRSCVGKSLAWNELYFAIAYMVRRFDFELYNTTAEDMKFVSETVFPKTRRGMMTVYAKVNNVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGT4</accession>
    <name>A0A317VGT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NADH-ubiquinone oxidoreductase 14 kDa subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_539024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463410.1">
        <property type="nucleotide sequence ID" value="XM_025612616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGT4"/>
    <dbReference type="STRING" id="1450535.A0A317VGT4"/>
    <dbReference type="GeneID" id="37114759"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="95" mass="10609" checksum="844460E8A10431B9" modified="2018-10-10" version="1">MVHKVLFWGGFGIAVRLWQLGIEMRPILAKESLWVYPLFAGVGGSFGYWLQGVENRQLKILAQRREAILEKRRRRDERNGADEGGVLAAAAAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJF0</accession>
    <name>A0A317VJF0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein bS6m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_539026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463413.1">
        <property type="nucleotide sequence ID" value="XM_025612618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJF0"/>
    <dbReference type="STRING" id="1450535.A0A317VJF0"/>
    <dbReference type="GeneID" id="37114761"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000007">
        <property type="entry name" value="37S ribosomal protein Mrp17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY73148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="121" mass="13680" checksum="B611E80E982AEE09" modified="2018-10-10" version="1">MLYELIAVVRPGSLQEVRDIARNAGIQVLRSGGVVRGYTNWGTFRLPRTTTKHQARYKEGHHFIMRFDASGPVQAAVRRTLGLDPRMVRFSVVKLGDKLEEIKDVSGKVEWTNARTITESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VN46</accession>
    <name>A0A317VN46_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_627361</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463700.1">
        <property type="nucleotide sequence ID" value="XM_025617417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VN46"/>
    <dbReference type="STRING" id="1450535.A0A317VN46"/>
    <dbReference type="GeneID" id="37119560"/>
    <dbReference type="OrthoDB" id="10017208at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF151">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="28"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY74507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="384" mass="43271" checksum="72C185A2A9F4BB72" modified="2018-10-10" version="1">MTEDSNLQPWATATTAAVTVLAFVCVCLRIISRLERKQKLWWDDWMIIFSMAWNLIVISFIFTMIHLGMGIHATHLPTPNIILIAKYLVVAEILYVFNLVWTKLSILLMYYRIFHFPYFKKWAYGIGTFVILWVICITFLFIFICVPVQKLWYPSLPGKCISQVGTWIANATSTIATDLVILLLPLPQVWRLQLRLSEKVALTVAFGLGFFVIFASAYRFTVLFSYTSTDSSYTLAPVVGWTAIEMSAGIVSACLPTIRPALQLAARKLGIQRFMPALLRSRSGNLSSKTNPSQIPADSATNSTAGMMNRRSFYHLPDEETGLGKGVLAQQIRLDEVLRPKHDRGLTVTNIRGSGNAHDDRLGGEEDEVPLHGIRVMKDFRQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNP1</accession>
    <name>A0A317VNP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY75984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463981.1">
        <property type="nucleotide sequence ID" value="XM_025612484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNP1"/>
    <dbReference type="STRING" id="1450535.A0A317VNP1"/>
    <dbReference type="GeneID" id="37114627"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY75984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="197" mass="22072" checksum="24EA8E9540440E21" modified="2018-10-10" version="1">MFQLHPLSADDLPALVALWYDSFSIPINLRLFPDTAGVRAWLEGYHRVSLDSPDQHYLKITLDSASSPLVAIVKWDFNTTAPGHRFPAWHDESDRAFCDAFFGSIDKARRKIMGTRQHYYLDTLLTHPGYQRQGAGSMLIRWGCDRADHDGLPIWVDASPEGAVLYQRFGFRDVSVPGVTPEGAVSMLRDPIPADAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNX9</accession>
    <name>A0A317VNX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S64</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_605286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464050.1">
        <property type="nucleotide sequence ID" value="XM_025616479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNX9"/>
    <dbReference type="STRING" id="1450535.A0A317VNX9"/>
    <dbReference type="GeneID" id="37118622"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012985">
        <property type="entry name" value="Peptidase_S64_Ssy5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08192">
        <property type="entry name" value="Peptidase_S64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58343" checksum="010853E973B1DAAB" modified="2018-10-10" version="1">MSETSVTEVYGRGDECYASPQIRIAGGRSPSSSDGRSSDDEYPGNLDGYDLFQQKAGDFYRGANEILELAGIKSGHMAFSAFLSTYDPEINPTVTSSIDAEKERIDSSWITAARKVHALLSEGGCVQFSVEITDKAAFLPQKYHPVARSHKIYPVWNTTLRRILKENDIQQWTSLGCYRVGTSDMAAECPVTVMVTVDPYAHKDWRGTRDCIVQTLDEIGCSDIVVMIKKDMANPPMVNAFFSNWVIATDIWRKNGVKPGDQNAMKALNFEQPSVEDMSIESKRLNDQYQDIVKSPSFKVIKEAMKNDELVFPRDRKIYDLNLQIAGHYESQLNKLRGMKANNSHSLGTIFACSGERVIESTTIKDARKTIIDWSLISVHSTRLGNNMSNTYDPLPDFMPPAMNIVPLAHRRSHEIGESAGLFKVGRGTGYTAGIYNSLRTAYIHTISQGGKETVDATIEHNILGDFSQEGDSGALIFDRHLEVVGLLFAGHQRTGITYFTHIEDVFHDIKRMTGALDVRIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPX7</accession>
    <name>A0A317VPX7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GTP-binding protein rhoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_201346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464219.1">
        <property type="nucleotide sequence ID" value="XM_025606100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPX7"/>
    <dbReference type="STRING" id="1450535.A0A317VPX7"/>
    <dbReference type="GeneID" id="37108243"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY76406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="193" mass="21720" checksum="7EAD9E2A79F617BD" modified="2018-10-10" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKHVELALWDTAGQEDYDRLRPLSYPDSHVILICFAVDSPDSLDNVQEKWISEVLHFCQGLPIILVGCKMDLRHDPKTIEELHKTSQKPVTPEQGEEVRKKIGAYKYLECSARTNEGVREVFEAATRAALLTKTHKSKKKCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQ92</accession>
    <name>A0A317VQ92_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463844.1">
        <property type="nucleotide sequence ID" value="XM_025612512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQ92"/>
    <dbReference type="GeneID" id="37114655"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY75217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="55" mass="5979" checksum="C8B771F192F0D1DB" modified="2018-10-10" version="1">MAVHWIWHAFPAMILLVVALLPCLPLRQNLKLPVGDLGAWDLLHGTDPADPASIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTN3</accession>
    <name>A0A317VTN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_549095</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464472.1">
        <property type="nucleotide sequence ID" value="XM_025613429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTN3"/>
    <dbReference type="STRING" id="1450535.A0A317VTN3"/>
    <dbReference type="GeneID" id="37115572"/>
    <dbReference type="OrthoDB" id="5403280at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF52">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY77285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="514" mass="56893" checksum="AE3042034C01AB23" modified="2018-10-10" version="1">MTSSDDGEKSSVPSSDVPEVTIVDWDGPKDSENPFNWSTPRKWLITITALLTTFVALMNGTIITVAHEAINTEFNISDANFPNSYWPVASWTMGGVFFSLLILPIMEDFGIRRSFLVTHFVLIIFIIPQGVAQNFATLIIVRFIAGGCVAVLGNSSASIIGNLFESELDRTKPVALWIVAYLGGSSAGPVVGAAIFQFLSWRWLSYMQLIWCAALWLVNIVILKETRGSVILQRRAQRLRAKGENAYTQHELEAEPFRQILLTSIRRPFKMLFTEYVVFFATLWSAFTVGTLYLFTQSVEQVFVGLYNWTPVQSGYIQAAIVIGEACGWTFSLFSARVYFNSAKRNKEIPGMPIPESRLYLSIGGGIFGIAGGMFVYGWTSYPSLPWIAPAVGLWMVGLGSVVVVSGIADYVVDAYSKYAGSACACFVVGENTVAAFLPLATSSMYNTLGFQWASTLLAFISLLLTLAPLSFIVWGKRIRERSPFMAEAMFDKRAEMMNHTPNHDGPAREIREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTT7</accession>
    <name>A0A317VTT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_559213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464175.1">
        <property type="nucleotide sequence ID" value="XM_025614053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTT7"/>
    <dbReference type="STRING" id="1450535.A0A317VTT7"/>
    <dbReference type="GeneID" id="37116196"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF49">
        <property type="entry name" value="LYSINE BIOSYNTHESIS REGULATORY PROTEIN LYS14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY76362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="692" mass="76855" checksum="1FBD5B30354309A2" modified="2018-10-10" version="1">MGACSAVTIQAPLVNATSKATTSMAAVSISMTNRSMRSSRKPPLRLPIIAPKNSLMGPSPGFDVPTTKKVTIRQHRLRFPPRSRTGCWYVLKCDEVRPQCNQCARLGHVCDYRPRLCFRDDTRRVRERMLDVRTVGNVVWDPKLRTSNTPPATGDLLPPFAALTSDEERERKAQASIPGTYHVVAIPESFSQLPEYMGETSEVNAGISATLEMGNGDHSQVGDGNSAYGPNVVVLKSFRSARRHFYPDRRSTPHFSLSAPSVSELIPDYPGDSMPHMQEGLDLLLLDHFRNFVCLQLIPKDGVFNIHGLDAAVFEREASSFPPLYHAMMALSVLSLVRQGVGQHIDASYYYNQVASSHGSVCGNEDFLSDAVYLTHFLLLIYEVVAAKPGSSNRWSHHVSRLLHLILLRQSIPRAERFPGIAWWVCHMDLYSLMGGAGTGEFVRAVLDNQLLLELQSLCYLVGPDGSPLIYADGSLPMIMRLYYDTFVLAIRIGLLAVETRGAKGPYFNNSSSQQQGLKELRELLVRLWGHEEIGYLFQNQASLPLRSQNLLQQLAILFHTCLLFSFTSLWSGQRSEPGAAPDEEVHHHAAQILQIVSAMIEKGSGGDRRFTAFPIFLAGAVAPSSGLKMMALELLSNLEDHEIGYNAATTCQMLQVFFEQQIQHSRRGGHALEIEWVEVLAEHGLQLVNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VU32</accession>
    <name>A0A317VU32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DUF1640-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_473474</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CCDC90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464181.1">
        <property type="nucleotide sequence ID" value="XM_025608478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VU32"/>
    <dbReference type="STRING" id="1450535.A0A317VU32"/>
    <dbReference type="GeneID" id="37110621"/>
    <dbReference type="OrthoDB" id="889336at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.340:FF:000018">
        <property type="entry name" value="Mitochondrial protein FMP32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024461">
        <property type="entry name" value="CCDC90-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14360:SF1">
        <property type="entry name" value="PROTEIN FMP32, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07798">
        <property type="entry name" value="CCDC90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY76368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="311" mass="34881" checksum="7E40F6C9FF56724E" modified="2018-10-10" version="1">MASQKSVTEVPRSILPRLTWNGSSARTTVTPPQTTALPAKRQQKQHPGRSWIPAGRQLHTLTFSPSSPFGFLAVSREVGTSSSIARRFPLAGKATSRPTAEPLGNPIRHNGVYVATFNPARRAFHASAPHQRDHHFDTLKFVQRLKDEGFSEEQAVAMMRVLNDVIQESIQNLTRTMVLREDTERSAYTQKVDFAKLRSELLNADSTEAQLTRSSHEKIAADLAKLNSRLRDEIGRTQASVRLDLNLEKGRIREEANGQEMRIKETETRIEQEVAGLRERVEAVKFSTLQWLMGVCTGTAALILGAWRLFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUK2</accession>
    <name>A0A317VUK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_604546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464466.1">
        <property type="nucleotide sequence ID" value="XM_025616461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUK2"/>
    <dbReference type="STRING" id="1450535.A0A317VUK2"/>
    <dbReference type="GeneID" id="37118604"/>
    <dbReference type="OrthoDB" id="2328924at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40128:SF1">
        <property type="entry name" value="PHYTANOYL-COA HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY77279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40430" checksum="634F77CA463383A8" modified="2018-10-10" version="1">MTTSLCESELFTSARLVADNYVLPQDDQYGNYYPTDPRNLSLESNFGPMIPDNIGYLQPTSKNTPIEIMRERFNRDGYLFIKHLLPRNQVLECRCKYFSYMAPSGLLKEGSDPVDGTFSEKDSRKFLPPGNLRPLFGLKNNYESEKYLDLMINAHEEPFYLHLCGSTELRGFIQRLTGWEDITMLQRTMLRAFVPDSELTPVHFDQMYLRAGPPTSLTAWVPIGDISLKGSGLMYLEGSTDIGRQTEAEFTRNAINLTDEERVSAFNKNMSDGGFLSRDTVAYGEYAQRKWLITEYEAGDVIFHDPFLVHASCKNKDPERRIRLATDLRFVDSNKPYDKRWMKVWRPLDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VV12</accession>
    <name>A0A317VV12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_472473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464655.1">
        <property type="nucleotide sequence ID" value="XM_025608436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VV12"/>
    <dbReference type="STRING" id="1450535.A0A317VV12"/>
    <dbReference type="GeneID" id="37110579"/>
    <dbReference type="OrthoDB" id="5394557at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="75"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY78143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="471" mass="51129" checksum="B826150FF1BD22E9" modified="2018-10-10" version="1">MYSSAPLDQAMAQPLYSPEEIGFDPSSKREALSLAPSGRRESHYESVDRSSGCMSPSTELDSKNRHSTRRRIQVACNRCRKRKIKCSGDPGDGQGCSNCRTSGNTNCQFLRVNSSMLQTKASSWNPYPSGTATMPSSQRPGLYVPSMTPKIGGAPMTAPPTFRMTSFPRASNYDMGSAHAQSAYHRFPFGVDPPVHYEEDASAYTTPSSAYMSGVSPNVFTDLCTWNPKTWGHSVHVDRSPHGPVFSDSDAETALTHSAFFNLTQSTDAPPIVPTMSFSAVEGQGENRTLPNPSRNQAQMGLCAFTTPEEALSGLPHDYRMSSWTPKNTFLNHGSMQSPHGGYRSGPIKRPKTTSDMLYGLLPSSGTSSPLISAGSFTTTMDTINAEDGQPSRTFSHDHLSDYGSDTYVYSSSERRDKGQSKPDGSGSMLLNGLSYTRPPLGHHSSPPLIPTSAFRSTTEMHHTAIPASQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVI7</accession>
    <name>A0A317VVI7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cap-Gly domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_577212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464713.1">
        <property type="nucleotide sequence ID" value="XM_025615167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVI7"/>
    <dbReference type="STRING" id="1450535.A0A317VVI7"/>
    <dbReference type="GeneID" id="37117310"/>
    <dbReference type="OrthoDB" id="5295208at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="5">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CAP-Gly" evidence="6">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY78404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="273" mass="30194" checksum="52746046A67CF2D0" modified="2018-10-10" version="1">MDFQTTPADVSVAITTPMANHSAEPRLLTERRVTPTWTVMQLKGKLETMTGVPPSSQRLLLRSPGRPDQWVDGDDTIIGDWGLMKGCEIEVHDSRPQSVRPNFTDLSSVEKYVLPTSTYESLSNSVLAWKKNQKLGRFDPNALTPEESLRQQSEKDAAEIQERGIAVTQRAIVLPSSPPHIRRGTVRFIGPVPTIPYPGVDPKTAQLEAVALPLWVGIELDEPLGKNDGSVGGQRFFTCPNKTGVFVKPEKVEVGDFPPLDLDDLDDELMEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VY84</accession>
    <name>A0A317VY84_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_567688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464908.1">
        <property type="nucleotide sequence ID" value="XM_025614644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VY84"/>
    <dbReference type="STRING" id="1450535.A0A317VY84"/>
    <dbReference type="GeneID" id="37116787"/>
    <dbReference type="OrthoDB" id="2152248at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY79336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="40458" checksum="D38463AD3419A3A6" modified="2018-10-10" version="1">MADPLKVLDDANCYAGTSSVSRKIYPIAGILTTVYGLDELPEQASEITCLWLLHHRGATQERMAGIAMTIIANWNATIHDARASPSQQVKGLIAVAFDQRNHGTRLVEPLANEAWRQGNPRHAQDMFSIFQGTARDVSLLIDYLPSFVCPQSDRKISDNLVLGVSLGGHAAWSCILHEPRISAGVIVIGCPDYVSLMADRARLSKLPSWTNSDIPGSQFLGSEAFPSSLVDAVRKYDPASRFLSHVSSKPDMGSLHTGPLPEPTESEKAALRPLLAHCVAGKRILNLSGGKDKLVPYHRGEAFLTWWKQAIAPSGWFADGAVTFEDLIDDDAAHEMTPKMFIEAVRFIYETLEASSNPLEKVGSVRESKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2A4</accession>
    <name>A0A317W2A4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_537393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464949.1">
        <property type="nucleotide sequence ID" value="XM_025612257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2A4"/>
    <dbReference type="STRING" id="1450535.A0A317W2A4"/>
    <dbReference type="GeneID" id="37114400"/>
    <dbReference type="OrthoDB" id="5414271at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY79377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="368" mass="40457" checksum="1C7DFAA53E4E6415" modified="2018-10-10" version="1">MALFTVTNARPVFRHSSASGHRAAYASYCGQWYVEWPIGDAAHVHFAAHDSLMLNKDVYPPAFELRVDRCLRMLAGVIESPASVPSTPFKCAFPGRKASGTWILEHTVRGFGGAHGSRHLYNMIGGNVNEVDFLFMKPLADDEASPIAEPITILSLPSSEANPRHQNSNQDPVTLYILPNEATILNNCLDYLPWTSLSWSIHRGLRDILIAFAKPRMNHHRSQLAQTLRSTVSTRPDRLIARGWDAQFVQDGSMADMAAGAVLAGSGNSGDAVRIVTDIAAVWCESREDITSYDETMFWRVEPTPLSPLSPSVISDDSFTSGPGGNNSGSEGLSSMAVVALVKFFVLEWSVELDYQMYHDLPLELYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2X9</accession>
    <name>A0A317W2X9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_577325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464859.1">
        <property type="nucleotide sequence ID" value="XM_025615173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2X9"/>
    <dbReference type="GeneID" id="37117316"/>
    <dbReference type="OrthoDB" id="3259529at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="122" mass="13496" checksum="A3082FE53DC99A9E" modified="2018-10-10" version="1">MRDVQASVRTINGQRLGTGQASFLDPFYLFKGKLRAAATRSKFHDSADMLWLADRYGNAIQAHKEGLDLRYIGLAMKRYPELELLTERLGVDLGNAREAVRDIDPSRLPAPAPGDGQRGLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4H8</accession>
    <name>A0A317W4H8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_496454</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465501.1">
        <property type="nucleotide sequence ID" value="XM_025609293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4H8"/>
    <dbReference type="STRING" id="1450535.A0A317W4H8"/>
    <dbReference type="GeneID" id="37111436"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="482"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="726"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1060"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY80899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1117" mass="123345" checksum="C1028D4806841C18" modified="2018-10-10" version="1">MPHPESPTPAMTTVVSKTPSGIPPTSEEIASIVNTIFNAETSQQSLDAAYALTNLLIQSVGCSGFQKYNILPEIKKAATDKKNGARRESAMLILGALFERFPREHPLSEVVFLLQDGGVLNLALDLLADKGAVVRDAAQYAIDALFGCLKAEALVNALLPAITAYLHQNTAKWQGFVGAYSLIEKMASKAQMGTGTLEEEREKDVLREAMGKTLKDLIPLVESGMHDLKNEVAKKSIKAMNAITTLLSNDDVAPRIPLLIKTMEQPSEQTLQKAIHALSQTTFVAIVTSPVLALLTPLLERSLNAPTTPQETLRQTVVVVENLTKLVHDPAEARTFLPKLKPGVQRVKDRASLPEVRELATRALDVIEKAMADKDVAQGVIVKITPEEVMVVLDAKIQEHGGLAHPEDATLFTLGKNYIAEMVREDVNCRMHDRIPACVAPYLRGLLQDGKHDEVAAAVQEHFIEEDHRKFGKPIPDDPNEVEIVNANFSLAYGGMLLLSHTNLRLLKGHRYGLCGRNGAGKSTLMRSIANEKLEGFPPQSEVRTCFVEHNQGEDADLSIFEYVQKDPLIAKEGEEHIRSVLLEFGFTDGPEGRQNQRVGSLSGGWKMKLALARAMLQKADVLLLDEPTNHLDVANVKWLQEYLKKHTDITSLIVSHDSGFLDEVCTDIYHYEQKKLVCYKGNLADFVKVKPEAKSYYTLSASIVQFKFPAPGILSGIKSNTRSILRMTNCSYTYPGASKPSLSEASLSLTLSSRVAIIGGNGAGKSTFIKMLTGETIPQTGKVEKHPNLRIGYIKQHALEHVEMHLEKTPSQYLQWRYANGDDREVHMKQTRILTEEDKAQLEKPVDLGDGRGPRRIEALIGRQKWKKSFQYEVKWIGLLPKHNTMISRETLLNLGFFKLIQEFDDHEASREGLGFRVLDPKVISKHFEDVGLDPEIANHNEISGLSGGQKVKVVLAGAMWNNPHLLVLDEPTNFLDRDSLGGLAVAIRDFKGGVVMISHNEEFVGALCPEQLHVADGRIVSRTNNAVALDRFEDSAASSPQPGSTAVNSTVTSAAASAVNSGAEEQGELKFKARKKKKLTRAQLKEREARRRLRHLEWLQSPKGTPKPVDTDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5G5</accession>
    <name>A0A317W5G5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_625966</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465443.1">
        <property type="nucleotide sequence ID" value="XM_025617322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5G5"/>
    <dbReference type="GeneID" id="37119465"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF158">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14490)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY80841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="557" mass="59183" checksum="940EBFDB857B17B8" modified="2018-10-10" version="1">MDEISPIDPESPPDNQNTTPPATTITPLQFDPPPPQRSTLRTTSIILILCLTLFISALDQTIISTTIPTITKSLNSAAGYTWIGASYLLAICAANPIWIRISDIWGRKPALLSTIVIFAIGSLLAATSRTMAMLIAGRAVQGLSGGGLMALVNIVISDLFSMRHRALYISATALVWVLAGTTGPVIGGALAEFVGWRWCFWINLPVCGVAFIIVLLFLDLHNPRTNLSEGLKAVDWLGGISILAVILLLLLGLDFGGVSFAWSSATVICMIVVGTVLIGMFLFVERKVARYPLMHLGVFNHWENVAVILVAAAHSMATRGAEYYLPFYFQSVKGASPTRSGVLVLPMMIAASVSDVVVGVVVHKTGRYREVIWLGSVVLTLGTGLYVLLGVDTSLAEIIVFQVVGGVGLSLLLSTPMLAIQNTVRQGDVAVATATLGFVRSIATSLAVVIGGVVFQDSMAMRKGGLVEAGLDAELVGLFGGEDAAANVDVIGSIGDVGQQRAVREAYACSIRNMFVLYTAAAAVGVLAAPWVRQRVMSGEHTETKTGVENMRERGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5J4</accession>
    <name>A0A317W5J4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 finger domain protein Acr-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_537191</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465177.1">
        <property type="nucleotide sequence ID" value="XM_025612212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5J4"/>
    <dbReference type="STRING" id="1450535.A0A317W5J4"/>
    <dbReference type="GeneID" id="37114355"/>
    <dbReference type="OrthoDB" id="5380854at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF11">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="570"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY80318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="628" mass="69710" checksum="592FE6F976B0586D" modified="2018-10-10" version="1">MSKGCYTCRRRRIICDNGLPTCRKCRDAGKECLGYQKPLVWVKGGVASRGKMMGRSFNDVMRAPDSRRDDSSSVSSNASPPSAADSPSQLGPDLSIDISLCVPPNVSGIQSVLDSPHPEDYDNQGTLQRAASVPAPWGMVDPLFKDLSQLSRYYIVHFNQNLANYLTLYSDARNPFRDLIPLVADSPLLSHVLAATGALHSAILASGDFSLAPWLSEGSSPAGPSMSSEQVEKAVISSMSRRPTSKAYEHFLGLKQRALQQLSSDIQDLVLRNDNRTLAAIMVLALMDAIESGDGAWKYHLEGAKKLLKGRQELSTFNPAQHIIKWLEDFAVDGFLIIQLMGSTLARPGSLTKPFYTSSMGPAMLKRLEETSWVGCPAYLLEVIFLIHAGLYFDPDVDPNTQPTMIFSSAFLPKNSNPLQSPGALLQHIQAFDPAAWAESMQSCWYLADLSMRTALAAVYKGAVYLYASRVLSRPRPGAATIPNHFGLTSDHAMVADLTIRQIALIPIADPHFKCLIWPTFIAGAECRDPSQRPFLLDKLRALYYDITSVNVRNAAWVLSVMWQKKDQKKAEKSMAHSNEGRRSWDSHSQFSNTNCDQTYDNDDDNDDEDEFDWIQELDESRIDWLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W678</accession>
    <name>A0A317W678_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mannitol 2-dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_536864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-mannitol + NAD(+) = D-fructose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12084"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16899"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.67"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.67" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465667.1">
        <property type="nucleotide sequence ID" value="XM_025612133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W678"/>
    <dbReference type="STRING" id="1450535.A0A317W678"/>
    <dbReference type="GeneID" id="37114276"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050086">
        <property type="term" value="F:mannitol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046029">
        <property type="term" value="F:mannitol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000129">
        <property type="entry name" value="D-mannonate oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000028">
        <property type="entry name" value="Mannitol 2-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050988">
        <property type="entry name" value="Mannitol_DH/Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43362:SF1">
        <property type="entry name" value="MANNITOL DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43362">
        <property type="entry name" value="MANNITOL DEHYDROGENASE DSF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="300"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00058571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY81599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="502" mass="56210" checksum="1E1112DCA2F764B9" modified="2018-10-10" version="1">MPPLKLNSKNLSQIAAAGAARVRVPTYRRGPAVKEGIVHIGVGGFHRAHLAVYVDQLMQKHGVTDYAICGVGLQPFDATMRDALASQDHLYTVIERSAKGSFAHVVGCINSYLFAPDNREAVIAKMAHPDTRIVSLTITESGYYYNENTHELQSGHPDIQFDLDPVNETSPRTTFGFLYAALARRHQQGLMPFTVMSCDNMQKNGSITRHMLESFARLRNPEVAEWITEKGAFPNAMVDRITPQTSPADKQALADNQGIEDSWPVVTEPFMQWVIEDQFSDGRPPFEKVGVQVVKDVHAVEQFEKHKLRLLNGSHSALGYPGQLAGFNYVHEVMENPLFNKFVWQMMQEEVKPSLPEIPGVDIDEYCKTLMERFSNPTIMDQLPRICLNASGKIPQFIMPSIAEAIWVNGPLRRLCFVAAAWFRYVNGIDDHGKPFKVDDPMVEELQAKARAGGTNPAELLSIKSLFGDDLRNDPRFLKEITSAMEDIARDGILKTLPKYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W7B7</accession>
    <name>A0A317W7B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_520259</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465639.1">
        <property type="nucleotide sequence ID" value="XM_025610099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W7B7"/>
    <dbReference type="STRING" id="1450535.A0A317W7B7"/>
    <dbReference type="GeneID" id="37112242"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="34"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY81571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="470" mass="51221" checksum="9FA264CB8C11D1A8" modified="2018-10-10" version="1">MDSTGHSNGLKRVPEWEDDPANAQNWSVRKKIYNTAVPSILCLLISFALAIYSPSHSHVQTAFHTSTTKSLLPFTMYVYGLAFGPMIAAPISETYGRRLIYLVMTPLAMLFILGAGFSQNLASLAVCRLLAGMFISAPLAVGAGTIMDMWSGPATGGGVTILMTIAFMGPAFGSLVGGWVAEYKGWRWSQWTTLFLGAACWVFSLGAQETYSRPILRRRAAKLGLPVPPSPIPRGLAGIRMMLTVTLARPVYMLLTEPIVALCSLYSSLNFSVLFCFLACVPLVYTDIYDFTPGQCGLVFISLALGCVLGCLGLLMTDQYTMSLHRRRHPEGNTPPPPEQVLWAAMLASPVMPAALFWFAWTSTCHVHWMSSIVAIGFFGCSNIMIFVSTVLYLTRVYGATSGASALAANGLLRYSIGGSFPLFTLAMYHNLGYSWASSLLGFLAVAFAPLPWLFFRWGSRVRENSAYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBB3</accession>
    <name>A0A317WBB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_495498</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Vacuole membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466010.1">
        <property type="nucleotide sequence ID" value="XM_025609265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBB3"/>
    <dbReference type="STRING" id="1450535.A0A317WBB3"/>
    <dbReference type="GeneID" id="37111408"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="8">
        <location>
            <begin position="747"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="645"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY83225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="812" mass="90245" checksum="1EB837B3A4F84BCE" modified="2018-10-10" version="1">MSSIARPPDPCLVAIILIVRSRAGPRFVFHYPPNPLSENGLRGAPKARRPSRTKSKSNDSSSSEDSSSSSSSEEDEAQPPNPAPNPPNSIQNQPHIGGCHPITGRRLSNFGLDDGTISGSPGGESQRAGSVGSGRGLLMMRKRGTNSDAEDDAGAASDRQEDEAGPYRPPWESLLGLPADVWEKLLSPSRSWHKRRFEVGINDLAFVGWPVFVREDGTWRKQRRKKRKPRAHWEGGELGHNENPGDDAEDDAREGSAELIAASTETLSPKQMAPYESQRASMQSVRSFRTLSEALDPDDKDCMTMFNVVFVLDPPLLEYSMRLREIYDNIIKKFSKALKWEQARTDYVWKEAQHISHIKEKAKEKRMSVNSLYSELINQSSLARAICTVFTSISASKIASVTLNADVSISLQIPPLTSTPWLPGPTDKAYPGLWLTTADSVTPVDDPTADENTAPHQVLAKHFALLLLDNEAAILKDVEASGGALAPALAHYIRCSKPTKSFAQISVSSGIPLSTIQMLASHLVYWRRARAIPPLHQRDTYVVSPNCDLSKLEVATVAYQAAFPTLPSLPKMLSAMSGTPRPYGSFIPSKDHKDTYFSILAWLLRGGWVTQLRAFARIKISPEIKMAVETALRQEEVDKYLIKRGSMPDAEQQDNIDDASSSSSSSLESHESGEETPMPGRYKRDNELDLSHSLLDRNTSLKTSSLILYPHRASPLESRWLEEIMSRFPELKGDVPDGDLEYAGLQTSLKKYWPTFTKYFNGYDALEKIPVRENLKRKLVWQILMRLGLVTGQQSSIPLDPREQVLVSVRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBF9</accession>
    <name>A0A317WBF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein of the small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_536745</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466060.1">
        <property type="nucleotide sequence ID" value="XM_025612097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBF9"/>
    <dbReference type="SMR" id="A0A317WBF9"/>
    <dbReference type="STRING" id="1450535.A0A317WBF9"/>
    <dbReference type="GeneID" id="37114240"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="145" mass="15838" checksum="9FA6451DEB712913" modified="2018-10-10" version="1">MGKGQPRGLNAARKLATTRRENRWADLHYKKRLLGTAYKSSPFGGASHAKGIVLEKVGVEAKQPNSAIRKCVKVQLIKNGKKVTAFVPNDGCLNFIDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDN6</accession>
    <name>A0A317WDN6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_518543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466418.1">
        <property type="nucleotide sequence ID" value="XM_025610037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDN6"/>
    <dbReference type="STRING" id="1450535.A0A317WDN6"/>
    <dbReference type="GeneID" id="37112180"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF4">
        <property type="entry name" value="SYMPORT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="121"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY84493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="618" mass="68673" checksum="125663BA55BDB72B" modified="2018-10-10" version="1">MAKDEVAPIQAVDAVIEPYNRNDPEITEKGTSEHINLNKNTSAKIKNPLADLSPAQVVQDVEDFANEHQLTDIFPLLKKGALVARDPQSFSEVPDITQAEVAAIEAEVTHKWRQPKSLYFTIILCSIGAAVQGWDQTGSNGANLSFPVALGIPETGPDASRNQWLVGVVNAAPYMSSAVIGCWLSDPLNKYMGRRGAIFMSAIFCLLSPIGSAVSQTWPQLFVTRLLLGLGMGLKASTIPMFCAENTPASIRGGLVMCWQLWTAFGIFLGTSANLAVKDTGDISWRLQLGSAFIPALPLLIGVYFCPESPRWYIKKGNMRHAYASLCRLRNTEIQSARDLYYIYAQIKVEQELAGESNYATRFVELFTIPRIRRATLASFVVMIAQQMCGINIVAFYSSTVFQQAGASVTGALFASWGFGLVNFIFAFPAVFTIDTYGRRSLLLFTFPQMAWTLLAAGFCFYIPQEQTAHIACIALFVFLFAAFYSPGEGPVPFTYSAEVFPLSHREIGMSWAVAVCLGWAAVLSITFPRMLAVMTPTGAFGFYAGLNVTAFFMIYLWVPETKQRTLEELDYIFGVPTRMHMRYQVFHVLPWWINRYIFRRQVTLEPLYKLDHLATSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE71</accession>
    <name>A0A317WE71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Intermediate filament protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_576497</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466103.1">
        <property type="nucleotide sequence ID" value="XM_025615139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE71"/>
    <dbReference type="STRING" id="1450535.A0A317WE71"/>
    <dbReference type="GeneID" id="37117282"/>
    <dbReference type="OrthoDB" id="120967at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="6">
        <location>
            <begin position="101"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="4">
        <location>
            <begin position="418"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="5">
        <location>
            <begin position="863"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="560"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1224" mass="137699" checksum="BC12145F5253E4B5" modified="2018-10-10" version="1">MALKHRDYALLGFGGFIAWGLAVKWLPVLRYLVYALALGILLSSAVFLSLVLLTARSLNHATLTSPKPLPVAFLARRHWEKEMQAVRTRSIYHPPSLYPQSFVVSEGIDELLTLATRDFIASWYQHISPNPAFVNEVDQVIRTAIGNLRHRLLAEDLISLVVSRIFPVITAHLKEFEVAERLVRGRNLTRNVTESEELDLAIASKYREGHLHPAAVLSVSDQKLMEQEYLRKIAVGLLPQLFPESVLNSRIVSVLIREIIACSVLFPLVSVLSDPDTWNQLMEAYGRTAIQDRKTVRKLRAALDEHASPAPKFKRGHPFPRLTPHDSERAFERFVRAIRRCNNISDARRFRALVASQLKRETMVEGQDQVYLRRLETGKRVLDQKVAKLSAPGGTQMTHASAAVSHFRRKNSVPQEASLVDVMHDASGLSYFMEFMDRQQLMSLVQFWIVVDGFRNPLEDDFGDESSPSSTTWTPADRSDMALISETYLSKPELKVTDESRRVVKTFLSAGKRASSEQYRKARTVILSTQSAILEELQETYYPRFKQSDLYYKYLASDEASQAGTQSPQRSSPSITEVPERRPLPPLMSRTSSQPGAKSKDLRRAAVSSSDVRSMGKLFDDDESSRRSFDSERSAPLFDDDYDTDPLAMSTQSLGRDSQNGETEANQNEVIENMEAALNDIIANEPKNSRIEDLKSADVSPTGLPGSDQYPKSPRSSMVLTRAESRTDDRIKPSIASLGLVDRSSRLGVFDDDLFPEQQKYIEDEYEEPVGTDNDSADQVHEAAPGDLGLTEAIEALTADIDKLGSQESVVDTLTRKAELTNNTAELRILRKSKASIQREMHRKEMQRQQYIIQESDNSLYGRSTVRIKSIVVGKEEDGREFAMYVVEVQRNAGEQMPAASWAVARRYSEFHELHHKLRMRYPSVRHLEFPRRRVVLKLQKEFLQKRRLALEAYLRKLLLLPEVCRSRDLRAFLSQRAIIPRNEAQSSTNGETKDLVTRIYNSVADGMDDFLGNFGVLDQLSTAGQNLISAATNQQATAVPDSDLATEDAVTAAEAEAELNAFEDRELEPFIKPICDLFLEAFELNKGNNWLRGRAVVVVLHQLLGGTIERKVREGARSLIQDDSLLRYFSLVRDTMWPGGVLRQSKIRTASERLKSRTEASLVLATLIPDLAGNVVGRANAQAAARRIFATLNNQRLNAHLVFTMLDEIVLVLFGGGDAGRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEC6</accession>
    <name>A0A317WEC6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466658.1">
        <property type="nucleotide sequence ID" value="XM_025611993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEC6"/>
    <dbReference type="GeneID" id="37114136"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="96" mass="10640" checksum="F04B4E3C4009ADC5" modified="2018-10-10" version="1">MTLSIHTLRAIQPECLCRRVTVHGTVTPDNDSGDNNNNDDDDDDDDDSGRLNGFIAGWQTTVTRHSDRLHSTVHTYVPPPGLQETDILTLPETNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJJ9</accession>
    <name>A0A317WJJ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_566312</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467090.1">
        <property type="nucleotide sequence ID" value="XM_025614546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJJ9"/>
    <dbReference type="STRING" id="1450535.A0A317WJJ9"/>
    <dbReference type="GeneID" id="37116689"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000182">
        <property type="entry name" value="Outward-rectifier potassium channel TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 12" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="211"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="383"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY86499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="667" mass="75214" checksum="2028442C13B55AAF" modified="2018-10-10" version="1">MDENKVGPRGTEKKSLGERLRSHFHPRPAEDDGPQDWWVASTAIPLIAATSAPLANLMSIIALVMPWKSKLLGRTDSSGAQAQELLTDPRWCIGLNATSIACGIAGNIFLLFNFTRTMRYIIALPASIILWCISTAILIGITIAVHVYDSPVSPDETYSQAYWSAVIAAALYFFLTIILMINMWGYVRGHYPQYFALTDGQRTLILQTTAFVVWLLIGAAIFHAVIDISFADALYFSDVTILTLGYGDITPPTSVGKGLVFPYAVMGIIILGLVVGSIHDFARELQYDNVVRKHVERKRQATIQHSISIEPGAEAAHFDYQPKHLRRSGMRSTIDAFSLVGRPKALIMREEKDRFDAMRAIQYETVLFRRWYNLILSLIMFGIVWTCGAVVFWKLEDITYFQALYFGFCSLLTIGYGDFTPTTNAARPFFIVWSLISIPTMTVLISEMSDTIVLAFKHATNVVADWTVLPHSGKYRNFLRRFPAIYAALQRHEENRRVAQGFHVGVDNAENGTKHPHHDPEHPPARSIEDLASEPDTATASGAASSGFQLAQQLAYAIQRTTRDVVAGEPKRYSYEEWVEFTRLIRFTDPSPDGVDVHEDEYGILNWDWIGKTSPMLATQTEPEWVLNRLCESLIRYIDIQARNASKTREEDEPTLKKQREIKFQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMV9</accession>
    <name>A0A317WMV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_535177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467269.1">
        <property type="nucleotide sequence ID" value="XM_025611722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMV9"/>
    <dbReference type="STRING" id="1450535.A0A317WMV9"/>
    <dbReference type="GeneID" id="37113865"/>
    <dbReference type="OrthoDB" id="4491087at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="639" mass="72341" checksum="B883F64702091E4F" modified="2018-10-10" version="1">MDVSTEPARRYTRSPHCLLCGERFTPDTHFRSVVLSKTDQHPVLTRSISFRGKGGIIHLQDLNVEIHSNPRLKSANAFSVHSLCWAALVGQPSVHKLYDLGRAMTPLTWTGLPQSLYNNRLVLSKSIYRLDAEIRQNNDEDNTLWRLLQRCGSLPTELVAIIWGLIDPSPVRCLLALWAADGYWTKSSSAPNSGSVYLVGNIFIYFTRVLDGTYICGIRQRDILYGHESKNSVEVSAPVSMEGLTFSLGPYGLRSIRFLSDTGTHHKSIGGAATMDTEFIGVIYPQPGAPLQLNIEWDALKIARISCPNNLEFGHNFLWETQLPWTEIYPPSERSFYDWPRHWDFTINPQRFMAYIPLHRDGFHLYGLTAFCSSKGLIGLGTHFRSRSHSTTSYWYGNQKGCLVHAQFGPSETVSLISVYWHPYDRLSKPYFAITTNKKRTLFLGPCFTSVEVGSKNIYDARDGGLMGLYYDKSLGISGFTSLGTVCRRLRDSSVKQIPDRSIPQTPQHSNTMNLSSTSIFEGFTSKASLINIQTLKACYIGPRCKGMLLIYDDDTRCILGQWYEGTSSQPDDIRELYFESNDVLRFYFMQNNGNQILNRIETSPQVSSPEESELFVDFKYGDDIIWLFSEYTDTIFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN22</accession>
    <name>A0A317WN22_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS multidrug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_535226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467329.1">
        <property type="nucleotide sequence ID" value="XM_025611730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN22"/>
    <dbReference type="STRING" id="1450535.A0A317WN22"/>
    <dbReference type="GeneID" id="37113873"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000460">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY87121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="489" mass="53486" checksum="D3FB56E526C556F7" modified="2018-10-10" version="1">MPDLEEQHEKASTPLMTPGSSTTTVALLYPETDLSQDIKWTLLALISSFTFISPLASSMFSPAIGYVAAEFRVTNETLLSFSVTIFLLGYTFGPLLLAPLSEIYGRRIIFSSANWFFVVWQIGCALAPNLTSLIIFRLLAGVGGVGCVTLGAGVIADLFPVQQRGMATSIWALGPLIGPVVGPICGGFIGESIGWRWVFWILLIASGTIATAIEILNRETYAPVLIRWKTEKLAQELHRPDLRSAYDVARGTAVPTVSQVLIQGLRRPLILLIKSPIVLLLSTYMAVVYGLLYLFFTTITSVFEETYGFSTGLAGLAYLGIGIGFFIGLTLIALSSDRIVKNLTAKNNGVFQPEMRLPTMIFFSCLLPISFFWYGWSAKYHVQWIVPIIGMVPFGIGLIGIYMPIQTYVIDCYPAYAASANAALTALRSLLGALLPLAGPKLFSSLGLGWGNSLLGFIALAFVPVPIFFNRYGQRIRERWTVDLEGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNE6</accession>
    <name>A0A317WNE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_595463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467666.1">
        <property type="nucleotide sequence ID" value="XM_025616227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNE6"/>
    <dbReference type="GeneID" id="37118370"/>
    <dbReference type="OrthoDB" id="4382065at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="233" mass="27321" checksum="32ABA1B97282641E" modified="2018-10-10" version="1">MGPFWPGEVPKFHALPDDIQRAILGYGLDIDSLHRLLAVKDATCLAWVANGEVLLAKMFEKSVDARLWPLAYLHYEVSQRDWWENESADVIYEMWERFSDMIYTPTPSSRQARDMLRFYKHVEFFASKYLADFRNELPTQNLEMLGHNMLISEKAFHVQRALYQHDILLQASATQCRTPNWSRETAEQACIRYLFSWSKSVRIQFRLINWYLHRDGSPRLLSASTRGEVLTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNJ8</accession>
    <name>A0A317WNJ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_556487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467827.1">
        <property type="nucleotide sequence ID" value="XM_025613870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNJ8"/>
    <dbReference type="STRING" id="1450535.A0A317WNJ8"/>
    <dbReference type="GeneID" id="37116013"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="187" mass="20975" checksum="F043F4A2E29E808C" modified="2018-10-10" version="1">MVSPQVTNLAIIVVMMQLAKKVPFENPDVLLLVRGMYILSNVLILGLYLYTQSKINKKNDLTTLKYVEPAPMGSGEEPRPVTTTNMEYDKQQLRQLMRSQLMGVGMMGVMHLYFKYTNPLLIQSIIPLKGAIEANLVKIHVFGKPATGDLQRPFKTANSFMNQGQVKSDKASVESAEKNWRGGVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNT8</accession>
    <name>A0A317WNT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_465213</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467879.1">
        <property type="nucleotide sequence ID" value="XM_025608103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNT8"/>
    <dbReference type="STRING" id="1450535.A0A317WNT8"/>
    <dbReference type="GeneID" id="37110246"/>
    <dbReference type="OrthoDB" id="5431013at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039327">
        <property type="entry name" value="CON7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36167:SF4">
        <property type="entry name" value="FUNGAL N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016366513" description="Fungal N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY88096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35199" checksum="A8C3BF2C4C764FC2" modified="2018-10-10" version="1">MSGLDIAGLVFSILGIAETGAQLSQKLCNVYRRVKNANRSIDSLSSDVGLTCNVLRQLGDNLSHDEHAKLYSAQALSTAQDILRECKVVFEKINKALNESNTSSARNVFQRVRKGVGFVMVEEELHVLGSNLERLKSTMLLLLNVIMYAGQVRSRADLSTLEEQRSLIQKLVEEKKQNDQRFENLSQALGACIVTNFMTINGSRSEDTLSAELRAYNRLLGLILSEIDTYQSTLEQTRYQRVRNGILDIHSKEISHIRVSHGDMAADALNDRVAKRVEPSCTHLPRLPKPRRGDTAPISPRASQHTHAATCMSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPU2</accession>
    <name>A0A317WPU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_535067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467838.1">
        <property type="nucleotide sequence ID" value="XM_025611691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPU2"/>
    <dbReference type="STRING" id="1450535.A0A317WPU2"/>
    <dbReference type="GeneID" id="37113834"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016299848" evidence="4">
        <location>
            <begin position="26"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY88055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="474" mass="51228" checksum="6EA5F815C8E8D26F" modified="2018-10-10" version="1">MRTFLQSPHVFLALLAMPLALPASAEKVLGAYIFARHGDRTAKVLKNTQLTDLGYSEVFSTGSYYRSRYIDSDSTLQVQGISEDIVKLSQISASTPSDTVLQNSATGFLQGVYPPVGASANETLADGTIVDSPMDGYQLIPLTMTDSGSNSEDTTWLQSATNCQNAEISSNNYYTSSLYNSLLSSTKDFYQSFSSMLNSSFSESAMNFKNAYTIFDYLNVGYIHNTTNVPTEDQLHQLLLLANIEQYNLAYNSSETVRAIAGAKLAGDVLQGLNKTVISKGKTKLNFQFGSYGTFLSYFGLAQLPAADVNFTGIPDYASSMAWELVTNSSGDFPPTSEISVRFVFHNGTINESMSDGPTVYPLYGQSSLTIPWSDFVHRTEKIAVTSTSQWCQVCGNTNGQCASYSNSSDSGSTTQTKSTNGMSRPVAGVIGAMVTLAVILGVEALFLVVGGFRVIKKRGTTEDAATDEEDKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQ07</accession>
    <name>A0A317WQ07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_466992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466911.1">
        <property type="nucleotide sequence ID" value="XM_025608187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQ07"/>
    <dbReference type="GeneID" id="37110330"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="236"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY86320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="414" mass="46429" checksum="5509335E436B9492" modified="2018-10-10" version="1">MSGYTRRNHDGPDSYIMNHQIALPVPYSHGDSHEFGVNDSGSYHFQQHPFNTYPSHFTSPYSHSGISSSTHHLSPHHSPGHSVPSTPDHVPLQHHSLQYMPQSRYLQSPGFMPLRDAFSEADIECQDSQNENTMLSEAVIPPLDGFPNVREFDQLMKSYVDDLSVKKQDKALIHAKRARNIKTVLMDPKDTAVESAQFRFWVKKMFKLQTVGSGTSDCTKMICHEGKPVAIREKLFKILTRAHQQCQHGGRDKTSAQVRQIYSWVPKELISRFVKICPTCQVRRGGSRLTPPSSRRSSPRLEVISRSPKLPSPPMSRRDSTLNGQLSLERPQSDYFTQLSGHTTWLDNQRSLQERQAVSPGHVRSFNGGAMGHLPSTLSGTLDSFHSDMPVASSQVSYSAGYPSAHGSSSHRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQA9</accession>
    <name>A0A317WQA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_490937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467948.1">
        <property type="nucleotide sequence ID" value="XM_025609137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQA9"/>
    <dbReference type="STRING" id="1450535.A0A317WQA9"/>
    <dbReference type="GeneID" id="37111280"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1340.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="6">
        <location>
            <begin position="162"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="235" mass="27151" checksum="1D4D866C2370FDB7" modified="2018-10-10" version="1">MDEDYSAGSVDADREMTRLWRTWRTVFEMLLDRGYEVTEEEVQMPLAVFKRNYSDPLGYPDRNKMKVSARPTEAMQAKYTPLPSKSNPDPQPDCGTIYVEFCPDATGVGTKQVRTFNHFVDENNFHTGIFITQTPISPSAVRLLSSMPGRICEHFQEQDLLVNITRHELVPKHVLLSPDEKARLLERYRLKESQLPRIQVSDPVARYLGLRRGQVVKIIRKSETAGRYASYRWVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSJ5</accession>
    <name>A0A317WSJ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indoleamine 2,3-dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_556667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Produces N-formyl-kynurenine through the oxidation of tryptophan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-tryptophan + O2 = N-formyl-L-kynurenine</text>
            <dbReference type="Rhea" id="RHEA:24536"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.52" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467378.1">
        <property type="nucleotide sequence ID" value="XM_025613882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSJ5"/>
    <dbReference type="STRING" id="1450535.A0A317WSJ5"/>
    <dbReference type="GeneID" id="37116025"/>
    <dbReference type="OrthoDB" id="540174at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000004">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF10">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00876">
        <property type="entry name" value="IDO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY87170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="431" mass="47979" checksum="D5217A300C4EA24E" modified="2018-10-10" version="1">MLDTPAISLVEYGVSLQNGFLPEVLPLRRLEDPYYSRWEDIVQDLPAIIKAGTIRQAVNNLPILSTENLQQEPEWRRAYVVLAYLTHAYIWGGETPKDRLPPSIARPFIEISNHLELPPCATYAALNLWNFSVPSEDTDLTDPDNLSVVTSFTGTKDEEWFFVLSVAIEAKGAQLIEFMLDGIHGASIDDEKRVIARLEQLSYGLGELGKLLERMYEKCAPSAFYHQLRPFLAGSKNMASAGLPNGVFYDLGDGQGEWHQYSGGSNAQSSLIQAFDIFLGVEHSATGETKSNGKSQTQVRSGYIQHMRNYMPGPHRRFLEMMARTSNVRPYVMSHKAGSALRDAYNMAAMSLGGFRDKHVRMVTRYIIMAARTPPPNHTPSQTNLATTTSTLMDKSHENITGGIRGTGGTDLIPFLKQTRDTTKAAARYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSN2</accession>
    <name>A0A317WSN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_70937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467418.1">
        <property type="nucleotide sequence ID" value="XM_025617613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSN2"/>
    <dbReference type="GeneID" id="37119756"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="81" mass="8192" checksum="407C241B70B25D9D" modified="2018-10-10" version="1">MGFASKIANSQNPPPNMSANKPGTYDGAPPTGYAGGPPSALQPGGGAGGLQQQQQHQPQQQQQPQYQAYQGSPAPSATSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSN7</accession>
    <name>A0A317WSN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_534899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467681.1">
        <property type="nucleotide sequence ID" value="XM_025611649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSN7"/>
    <dbReference type="STRING" id="1450535.A0A317WSN7"/>
    <dbReference type="GeneID" id="37113792"/>
    <dbReference type="OrthoDB" id="10044938at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12342">
        <property type="entry name" value="RRM_Nab3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034167">
        <property type="entry name" value="Nab3_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052600">
        <property type="entry name" value="Nuc_rcpt_coact/corep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295:SF6">
        <property type="entry name" value="NEOSIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23295">
        <property type="entry name" value="NUCLEAR RECEPTOR COACTIVATOR 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="436"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="512"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="870"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY87898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="929" mass="99694" checksum="D6A2C4D42841B0FB" modified="2018-10-10" version="1">MTPSSPDEALHFRGKTLTPESPRPLHVAEPARIPVLQNQMDPVFNDTSTYEKSEAFLGNTSLQAHPNDPTSFRGPYAGPGEVRGTTGAVQVPEQPPPRQPPPHTQGSSHSGSSQGKDGSMNGIANALSATATTAQTSFASDQPAPPMATGPSSAVQDAPANSSLTTLPSSDPVSLLAPPFPDVHSSSSHAAQNIPSASEVDHAVASWTAPSAPPNRLDSQSKSDDNTGEDGVDFQNLLDNLPPSSTAPSAPAVSETAPLFADVSALPPAGTDEDALQSALGLPPRPPPQAKPSIHPNYNATDDIRSYHQLPPNSSNAQPSPPASYSAQQSNYQSGLGLPSLAAAGAPGTSSGASALPPPPVPSFQQSSPSASESQDPPVPANNKNGRSERPTARQPKSADEDTPWGPDVQKKYDEFLHDERIYVTEGLWDRFPPGSRLFVGNLPTERVTKRDLFHIFHKFGKLAQISIKQAYGFIQFLDSSACKEALDAEQGAVVRGRKVHLEISKPQRSTRPGAAPAEASRAPPSRRSRSPEFSRSGPSGSRNARAPADRYDRSYESGRVPFSDFRDEPTHRRRDDYRPPPPPRSPSPRAFRARDGYRSRDRTPERYDRRERRRSRSPYTRDRRYRSPSPRGRGAYEGDADLPVPRRAPRDVPEVQILVLEEVDRNFIFHVENAFRNRGLRVDVLVLGPRIPLNAAVQRQVQEGVLAVVRLSRPSQFSRKIPLQLFDRSGGPDNFRSNEYPDVEPSIAAEIVFHAQSMQRGAPPAPFPPNPAAFGVPPLPVPAASVPPVPQVPQVPQAPLPMANQPNIANLITSLDGPTLQSLLGVLQQRPPAIPSAPQPFPAASTPHGAADLASLLNAATRPPVAANPQQQLPSQPFPLQAPNAPVVSDPNLISLLAKGLGGQQPQNQAAVGSQVQNIMNQLGKWKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSX8</accession>
    <name>A0A317WSX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_61626</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467811.1">
        <property type="nucleotide sequence ID" value="XM_025616801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSX8"/>
    <dbReference type="STRING" id="1450535.A0A317WSX8"/>
    <dbReference type="GeneID" id="37118944"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000247">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000106">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF104">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="92"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY88028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="552" mass="62731" checksum="43121667EB891EC2" modified="2018-10-10" version="1">MTTDGVKEVPTDTVPASDDTKTPNVASSSSSSLTESDNRVVKYVSDGAFDSSEDPRFYKPIPEYESAHRWDPYFEWTEEEEKRLIRKIDLRVCTFACVTFFALQLDRGNIVQANSDSMLADLGMTTNDYNNGQTIFYLTFLFAELPSQLLSKKVGPDRWIPIQMVAWSFVAAFQAFLKNRAGYFACRALLGLLEGGFIADTILFLSFFYKSKELPQRLSYFWVSYEATSIVGAFLAFGFLHIQNSDGGGGWRYLFAFEGLITGLIGIIAAFWMPASPTQTKGGFRGKDGWFNEREEKILVNRVLRDDPSKGSMHNRQAVTPKMLWHALCDYDMWPIYLIGLTWMIPNTPATSYITIELKALGFGTFETNLLTIPAYVIFIINLLFWTWISERFNQRLLLGVVSELWCLILLITLEVLPDGVSAWARWIINALLIGAPYVHAIIVAMTSRNAGSVRTRTVASAVYNMMVQASSIIASQIYQEKDKPYYRVGNKVLIALSVLSMAFFIGAKFYYIWRNKRNSARWNAMSTTEREEYLAANQDLGNKRLDFRFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WV12</accession>
    <name>A0A317WV12_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_420364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468642.1">
        <property type="nucleotide sequence ID" value="XM_025607399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WV12"/>
    <dbReference type="STRING" id="1450535.A0A317WV12"/>
    <dbReference type="GeneID" id="37109542"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="14"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="117"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY90264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="143" mass="15612" checksum="143A326A86653D88" modified="2018-10-10" version="1" fragment="single">LEANCDPDIKDTEYGWTALSWAAGHSHEGVVRLLLTKGVDLVGSDYKGRTPLSWTYILRKGHANVVQFLLDNGAELILTKSMLNRHPLMWAVMEGNADVVKVLLSQDVNLKLQDPMTGETPLLWAAGSDHETMAMLLLGGGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVY9</accession>
    <name>A0A317WVY9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_545464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468383.1">
        <property type="nucleotide sequence ID" value="XM_025613239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVY9"/>
    <dbReference type="STRING" id="1450535.A0A317WVY9"/>
    <dbReference type="GeneID" id="37115382"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000043">
        <property type="entry name" value="Protein transport protein sec9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000048">
        <property type="entry name" value="Protein transport protein SEC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="6">
        <location>
            <begin position="356"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY89472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="419" mass="45919" checksum="94E543DD129381EB" modified="2018-10-10" version="1">MGRFGFKKSGDDNEEDSSNRLALFGSRSKSKSPAPPANPYAKPIPTDPYTKAKIQAGVAPLPAGEQPPPANPSGAHNIPGDHKHQGYAPNRYGNQGGYGSDRFGGGGAAPAASRYGPGGYGGLGSADPNDPADGNRDALFGGARERVQQQQQAGGAPPPPYSEGSAAYGGGSNEYNTSTYQERNLTAEEEEDEEIQTIKQDMRFIKQGDVASTRNALRIAAQAEETGRETLARLGAQGERIHDAERSLDVATVEGRIAEEKAKELKTLNKSMFAVHVSNPFTSARRRRERDERVLNTHRAERDTREGTEKEAFKTNQRMERTFREIDREAAKQTTRSRTNVTERAKYQFEADSEDEAMENEIEQNLDLLSGAAGRLNGLARATGRELDEQNRHLERITGKSDFVDDQIAMNRAKLDRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWY8</accession>
    <name>A0A317WWY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_44039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468618.1">
        <property type="nucleotide sequence ID" value="XM_025607503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWY8"/>
    <dbReference type="GeneID" id="37109646"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="92" mass="11168" checksum="9EC0F9849C922CA0" modified="2018-10-10" version="1">MIRWPSRFLQHPQPPRHRHLQPQMRLRVGQHRGLKSNFNTRHWSTLTTGTPPWEPPFGPHGPFPPAIKGHQDRQIHQDHHCRHYHRDHFHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WXI3</accession>
    <name>A0A317WXI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_555850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468409.1">
        <property type="nucleotide sequence ID" value="XM_025613827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WXI3"/>
    <dbReference type="STRING" id="1450535.A0A317WXI3"/>
    <dbReference type="GeneID" id="37115970"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF19">
        <property type="entry name" value="LYASE (GLO1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="188" mass="21107" checksum="52EC1AB03A3F511E" modified="2018-10-10" version="1">MLRTRNPSRTLHFYINLMGMRTVFTMNTGPFTIYYLGYPATSADCADLPAWAARVSDIPTLTKTLGLLEFYHIHGTETGTDQEGEEGEEKFRVCTGNEPPNLGFGHLGFTVPDVGEAVERLRREGVKVVKELGDVSRRSVPLSRWEEERRCGVGEISQGFRDIWGRIACVADPDGYLVELVPQDMELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY85</accession>
    <name>A0A317WY85_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">High osmolarity signaling protein SHO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">High osmolarity signaling protein sho1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7 8">Osmosensor SHO1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Protein BZZ1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_533466</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the BZZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469061.1">
        <property type="nucleotide sequence ID" value="XM_025611339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY85"/>
    <dbReference type="STRING" id="1450535.A0A317WY85"/>
    <dbReference type="GeneID" id="37113482"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11912">
        <property type="entry name" value="SH3_Bzz1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000161">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000040">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035459">
        <property type="entry name" value="Bzz1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F-BAR" evidence="17">
        <location>
            <begin position="8"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="16">
        <location>
            <begin position="407"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="575"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="15">
        <location>
            <begin position="683"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="455"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="635"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY91333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="741" mass="81999" checksum="5AB29F6EE22AF57C" modified="2018-10-10" version="1">MATPDVAPHFGAELKDAFKPVNNWVSNGIGWLDEIQQFYRERSVIEKEYAAKLTALCKKYYDRKAKKISSLSVGDTPSMTPGSLESASLTTWSTQLSAVESHAAERDQFGTELLTHVAEPLKQAANQYEELRKCHVDFHAKLEKERDSSYSDLKKAKGKYDGACQEVEARRKKMEGSFDHSKPKAQAAYQQQILEMNNVKNTYLISINVTNKMKERFYHEYVPELLDGLQDLNETRVAKLNSLWSLAAQLEKSSLSKSVDHMTNLMNEIPRNVPHLDSLMFLRHNVTQSQEPANVGFEPSPIWHDDDALITDEAAKVFLRNLLSKSKTQVRELRVETDQKRREVEAAKRVRESIQQGKDKRNEVEVVRSIFFQQEALHECDRRRLTAEVETSTIMSVVGDLSLGARNHNFKSQTFKIPTNCDLCGERIWGLSAKGFDCRDCGYTCHSKCEMKVPAECPGEQSKEERKKLKAERQEQANAAPAPLDLETTTTSSTAPSLTRKDTMNSLSSGYAVSANRSMSNATSQSPSASPAELPTPIAETKPTPVRKNRVLAPPPAQYISSPPPTPGLSSSAKTSEQHGKMLYAYQAGGADEVDVQEGDDIVILEPDDGSGWMRVRAGPDEGLVPASYVEVGPAPSPVPSTSPGFATDRPGSTYSNSSASLTGGSAANKRIGPAVAPRRGAKKLQYVEAMYDYEARSDMEWSMTEGDRFVLVNRDGGDGWADVERGGVTKSVPANYIQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYC3</accession>
    <name>A0A317WYC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_389659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469101.1">
        <property type="nucleotide sequence ID" value="XM_025607312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYC3"/>
    <dbReference type="STRING" id="1450535.A0A317WYC3"/>
    <dbReference type="GeneID" id="37109455"/>
    <dbReference type="OrthoDB" id="5423111at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF1">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="7"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY91373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="175" mass="19181" checksum="6C14ADA82D4DFD85" modified="2018-10-10" version="1">MAARGIQLGLRIWEFIWTLLIMALVGNMIAEAFAGNPATVNYAMFVSAFSMFTLFYLVPSSINMDWAIHPVFVIVIDTLNAIFFLTAGIALAAKLECHSCSNNAYTLSNEITNGSNNRQKRCREAQASTAFLWFAWAGYTASMVLSIISSRQTGVNLRGRTGPARGVTRPSMAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYN4</accession>
    <name>A0A317WYN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD dependent epimerase/dehydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_489770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468755.1">
        <property type="nucleotide sequence ID" value="XM_025609098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYN4"/>
    <dbReference type="STRING" id="1450535.A0A317WYN4"/>
    <dbReference type="GeneID" id="37111241"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="359" mass="38873" checksum="A82FC2CA8979E199" modified="2018-10-10" version="1">MSHNILLTGTSGYLGGTLLAHLSTPSNPSLPPYKTLYALTRTPSQSHSVEQYGAVPLPLDLTDTPTLIQTIIDKKITIIYFLIDATSSKIQVPMIEALGKVKEITGQEVHFLHTTGAKLFSGHAGHPTEGSFGDGNGEEVYEMQGLAGGRVGNPFIKEALKVNSTIINTAEKHGVKSYIFIPCIVYGKGEGFGNRISIQTVAVVKAAMRTRRVFRVDDGAGRAVWPVSHIQDTVSLYLELLRNMLQGTDALGHGKNGYYLAASGSVAWDDLYAAMGKRLAERGVVDDATVVDADDEALEKIGEALGRPKDFVRVEMGGSCVMEAKHGLQIGWKPKYAPEHALEVAGEEVDWILENLERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZI4</accession>
    <name>A0A317WZI4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_390445</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469119.1">
        <property type="nucleotide sequence ID" value="XM_025607320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZI4"/>
    <dbReference type="STRING" id="1450535.A0A317WZI4"/>
    <dbReference type="GeneID" id="37109463"/>
    <dbReference type="OrthoDB" id="431169at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12245">
        <property type="entry name" value="RRM_scw1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000089">
        <property type="entry name" value="RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="402"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY91391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="607" mass="63428" checksum="223B86ACB33C663F" modified="2018-10-10" version="1">MSGSSNQSTRTSPGSYSTTQRTPSVSSGASPTHQPLSSSQVPSTAQNAMSTDVYNTPASQAPTSLGPSFTYPFSPIGPSPSFDSVSSTAMRLGDSDRSAQGLNGFIRPANGTSGGAILMRKLPRNTSRDALRSMLLFAKDFVDADFVPSDAPEDNGYLCAVARFSTLAAAEEARALLDGKPNSKNDATMVVEMFYGSVGSSLAPRRNTIDHTATRGLLGHVNGGLPRQSSRFNGTFQTLEMLSATTGSSTGDALPPSERLHSIFSPQSPIGNGVPELPRVSGKSMIDQDIDEDTGAILKDPVGYAENGHSASASAPRRSTNPQMLHNQFGNLSLATNLNSPPLQTYSSGGTAHIGVPNPTSAFPQPMNNNIGAGHGFPYGNPHVPRHSLPAANPNDMNPPCNTLYVGNLPPDTSEEELKALFSKQRGYKRLCFRNKQNGPMCFVEFDDVGTAGKALNELYGVKLSNSVKTGIRLSFSKNPLGVRSGQPGSMSASNAMAPQGSVPGGSSLGGMHNHMFSTVSGPPPGLSAPPGLPPPMAIRNNVTVHSTGSPNAPLPNNGAFNANSGLGIRTNPMNPMVSPPPQLTGGTSGPNMGAYNSYYPDYMMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0F9</accession>
    <name>A0A317X0F9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_555460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469379.1">
        <property type="nucleotide sequence ID" value="XM_025613800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0F9"/>
    <dbReference type="STRING" id="1450535.A0A317X0F9"/>
    <dbReference type="GeneID" id="37115943"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF6">
        <property type="entry name" value="BIOSYNTHESIS PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G02660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="470" mass="53079" checksum="C40FD29C68A515EA" modified="2018-10-10" version="1">MLANAISFNHLPGTDDAILPFHATALNIMHILKSYSVNCKDVGTVAEDMRTFLPRIMSYIEKQEPIRMVLPAFPFKSPNYQDKTLGVLPDLAEELALHHLNGLCLNISRVYKHGAEVHITSNGLVYNKLTIHFRDPSFSPDAAIKTDINICLTYRGYIKFLTKDLAQKVVSKSKRAQATEIAQTARSMIVQGQMFAAAIQAQRGNYVQLSIHESAKGRKLSVPLIPQKQGIISHTPWHSCVAVGVNSFYRATHVNQVRDTHDLAENGLQIQFEHLYPCGLIIRPFSNTSQSPSLRSLPMRKIRQLSCHMSPVICCGFSDTNNKDIFVDKAAELGKVTAWSQDIIVKVRDSKRQDKNNNNIKSNEAMPMHFDGMFRLEYKTDPTTGETNRGMDNDGFWDTKIYNLPLVIPYPHQPWTVNETKFSTCNVTIHNDNASLIPQIDDLTYNYRDVLINDNISILHTRTVYTSDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0R4</accession>
    <name>A0A317X0R4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_564506</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469489.1">
        <property type="nucleotide sequence ID" value="XM_025614427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0R4"/>
    <dbReference type="STRING" id="1450535.A0A317X0R4"/>
    <dbReference type="GeneID" id="37116570"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF4">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 9" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="NodB homology" evidence="11">
        <location>
            <begin position="477"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="10">
        <location>
            <begin position="716"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="719"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY91761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="789" mass="85503" checksum="2F641B6F755BF261" modified="2018-10-10" version="1">MADRHSVQLSLNSLLSKLGDPDPDMRYMSLNDLLGILNSPSSTFLAHDQGGSSALAECLLKALDDQHGDVQNQALKCLGPLVLRMPFESLALLLEKLTNLTASQTIDTSVPNTALRYIVTALPRPQAGQPPSQEATMAYSAVSRGLIPRLTGPTPSPTSRRGSIVKGMLEKDPLKGFSSDAIDVLIQVVTCFGPLLKEPELSALQNSVMSIIDNDTAGTVVTKRALAAISALVFHFSDAQLSAFVGGLVQRFNSTQLSTVHRRHLIAAVGGIAKSAPAKFGPHLPTLAPFIFSAVGEDNLPQAAESLLPPTFLSIFSLLFSHYTSHHPYQNIYCLHYPASYSGLHFTTPYLLTMHMLRLVASGLGLVACSTARNIINLQPDHQGTRLLPLSHGNSSAQDLVGRGASNRCGPDVGKCAPGKCCSTAGNHCSSPDCQIDYGHCDAHITPGGPPTDKIPRPLNGNVPYGPRFIRSCTVPGTIALTFDDGPKEYTQDLLDLLDKYEAKVTFFVTGNNNAKGEIDSPGMPWASLIQRMHRSGHQVASHTWSHQDLSKVTQSQRRVQLLWNEVALRNILGTIPTYMRPPYSSCTAESGCLNDLGSLGYHVILYDIDTEDYSHDSPEAIQRSKDIFDRNLDSRIEFDRPWLVIAHDVHEQTVHNLTEYMLKKLIAEGYRAVTVGECLGDPPELWYRKDDNFDDRNIRKSNKTKNSDTKPVSVDGMCGENTSCLGSRFGPCCSSTGFCGSMSSFCGEGCQPDSGSAKKPSKSDAGSLLQLSPSVAVVILLTLMVLME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3T4</accession>
    <name>A0A317X3T4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_544315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470055.1">
        <property type="nucleotide sequence ID" value="XM_025613175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3T4"/>
    <dbReference type="GeneID" id="37115318"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="231" mass="24891" checksum="4CFC140D115FF84A" modified="2018-10-10" version="1">MVHGGEAVSSFSIKAKISADAYQLSPPQMSPAVLQHNSNKGLSKQTFLFHGQSFGWKKASGYPTSGNRISAVEIAGHRDAASDHSACAGQSARGTDRLTAVQGPGQFKWNRSDPEMSGFHRRSGRPGASCNSSLACISLFERIPTEDPASGVSLSHLHFTCKSLTWYLLPGQSLGLILVLAVAENMDLLKSSNRTTTTTKHLSEELRKETSPKKIWIIESSGLPNTRPVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X431</accession>
    <name>A0A317X431_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase NM domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_488203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469436.1">
        <property type="nucleotide sequence ID" value="XM_025609059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X431"/>
    <dbReference type="STRING" id="1450535.A0A317X431"/>
    <dbReference type="GeneID" id="37111202"/>
    <dbReference type="OrthoDB" id="2588832at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="9">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY91708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="511" mass="57260" checksum="8B5BAE4D72256EF4" modified="2018-10-10" version="1">MSKSFTRAEVAQHNTEDSVWCIIDHRVYDLTDFIDAHPGGSVVLNQIAGTDATVDFYNLHRQEVLEKYKDLCIGTITGETPVVVTPEPGSLSQVPYAEPLWLRPQFKSPYFNDSHHRLQKALREFTDRYVTPEAQEKEKDGSYISQDLIDRMAEAGVLAMRLGPGKHLHGRKLLGGAIDGKEFDYLSDMVLSQELVRANARGFQDGNMAGMCISLTAVQQWLRDEPLRQKVTEEVLSGKKKMCLAVTEAFAGSDVAGLRTTAKKTPDGKHYIVNGTKKWITNGMFCDYFVTGCRTEKGFSVLLIPRDEGVETKQIKTSYSTAAATAYVQFENVKVPVENLLGEEDKGFIVIMSNFNHERFMMVCSVVRMCMTVVEECMKWCNQRIVFGKKLIEQPVMRQKLARMIALCESNQAWLESIAYQMCNMTYAQQSANLGGPIALLKSHATRSAQEIADQATNIFGGRGLTQSGMGKFIEMFHRTYKFDAILGGTEEILADLGVRQAMKKFPKAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X476</accession>
    <name>A0A317X476_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_583233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469752.1">
        <property type="nucleotide sequence ID" value="XM_025615544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X476"/>
    <dbReference type="STRING" id="1450535.A0A317X476"/>
    <dbReference type="GeneID" id="37117687"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016334749" evidence="2">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY92991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="363" mass="38278" checksum="FC975DC42B73D2D4" modified="2018-10-10" version="1">MHSVSKGILLVLSSNLLAVSARPLATETDSAPATTTTAPANYGNYGDYGNYGNYGSYEAYKRDEEPESSSTESTAAPTTTTAAGYGNYGNYGDYGSYGSYQAYKRGEEPESSSTESTVAPTTTAAGYGNYGNYGDYGSYGSYQAYKRDDEPESSSTETTAAPTTTTTAAGYGNYGNYGDYGSYGSYQAYKRGEEPESSSTESTAAPTTTAPASYGDYGDYGNYGNYGSYEAYKRDGEEDTTTTSSAPATTTTAPASYGDYGDYGSYGNYQAYKRDEEPEVSSTASATTSTETATTTAANYGNYGDYGNYGNYASYGSYKRDAEPEESEPSSTSEPASTTTAPAGYGNYGNYGNYGKYGSYGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4I0</accession>
    <name>A0A317X4I0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Synembryn</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_532413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470244.1">
        <property type="nucleotide sequence ID" value="XM_025611114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4I0"/>
    <dbReference type="GeneID" id="37113257"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="467" mass="52018" checksum="96E37193DBFB8C10" modified="2018-10-10" version="1">MEFRPLQGPEKLQRVTQLLGSLKTDLGEKSLTSKQRVQTLLELRQHGTNPSHAHPIYSKEGMEILAKYGADGDTPDVRRAALRCVANALLLDESMRQVFVDTGYGGRLAERLKCDSSEDEMVISRILFLSTYDTTMDFENLIKHHSLGDNVNYQIVRHAKQFPKSGKKSLSQIDELALIDTLKLIFNVAKIYSHLSATFSASIPHIFKMISRLDIPPKPLEGLLSYLLNCLSTLDLENKKGKVFDNSPIFPTFNQNCNVDKLINILDQAVSAYGPDELETKAIPLFHSLVVIHEMAPDGPRKYMQWLLLPEDNDRSRPIGQSDTLSSKLLNLSTTPYPNLKTAISELMFVLSGKDAENLTKNIGYGFAAGLLASRGMEIPKTAGEAFATNPNGFSPDVNPITGQKWAAEKKDDGPPMTKAEKEREAERLFVLFERARANGILSVENPVTRALQEGRFEELPDSDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X537</accession>
    <name>A0A317X537_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_573512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469398.1">
        <property type="nucleotide sequence ID" value="XM_025614972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X537"/>
    <dbReference type="STRING" id="1450535.A0A317X537"/>
    <dbReference type="GeneID" id="37117115"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="3"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="142"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY91670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="361" mass="39705" checksum="1C99CF24EF37B6C2" modified="2018-10-10" version="1">MVRWGILGTGDNALKFGKDLLIDPTTRDVHDLTHDFLAVASSTSLDKAQSFLSAVGAPSTARAYGSYEALVADPDVEIVYIASPHSHHFPHARLALTGNKHVLLEKAFTVNARQAEILVQLARERGLYLMEALWTRFFPLTRHVQQLVREGRIGTVQRVVAERNLGRDVERLYGTSHRLVNPALAGGALLDLAVYPLTWVRLFLGSEGENNSRSLQVSSAVIPYEATGVDETVTVVITSPETKTQGVATASLRVTADPSEPGVRILGTKGQVQVYGPAARPNWIRVVTYGSSEAPETTSFPIPVGHGLFWEADESARCIREGRIDSEGMPLKDTLWMMRVLDEVRQQHGLRYSEELESTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X558</accession>
    <name>A0A317X558_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial outer membrane protein porin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_532660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Forms a channel through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470487.1">
        <property type="nucleotide sequence ID" value="XM_025611166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X558"/>
    <dbReference type="STRING" id="1450535.A0A317X558"/>
    <dbReference type="GeneID" id="37113309"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000004">
        <property type="entry name" value="Por1 mitochondrial outer membrane porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY93726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="284" mass="29953" checksum="130658AE227D222C" modified="2018-10-10" version="1">MSAPAAFSDIAKAANDLLNKDFYHNSAANLEVKSKAPNGVTFNVKGKSAHEGPIAGSLEAKYVDKPTGLTLTQAWTTANALDTKLELDNNIAKGLKAEILTQYLPAKQSKGAKLNLYFKQPNLHARAFFDLLNGPSANFDAVLGHEGFLVGAEGGYDVQKAAITKYSAAVGYSVPQYSAAITAGSNLTVFSASYYHRVNAQVEAGAKATWDSKAGNSVGLEVASKYRLDPSSFAKAKINDRGVAALAYNVLLRPGVTLGLGASFDTQNLNQAAHKVGASFTFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X595</accession>
    <name>A0A317X595_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytokinesis protein sepH</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Serine/threonine-protein kinase sepH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO94DRAFT_622106</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Required for early events during cytokinesis including localization of cytoskeletal components to the cytokinetic ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470510.1">
        <property type="nucleotide sequence ID" value="XM_025617044.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X595"/>
    <dbReference type="GeneID" id="37119187"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000176">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000212">
        <property type="entry name" value="Cell division control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000246">
        <property type="entry name" value="Putative Serine-threonine kinase SepH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF26">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DDB_G0283821-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="11 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="59"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="347"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="458"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1197"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1213"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="1315"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00056925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PWY93749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1336" mass="149633" checksum="F928E6D37C5A3BC4" modified="2018-10-10" version="1">MVSRSSEASEGLPPPSKTPGTPAKTRLTRLGSSPSKQDKPKDDRVVKSSAKDVAELKDYQLGDCLGKGAFGSVYRALNWNTGETVAVKQIKLADLPKSELRVIMLEIDLLKNLDHPNIVKYQGFVKSVETLNIILEYCENGSLHSIAKNFGRFPENLVGLYMSQVLHGLLYLHEQGVIHRDIKGANILTTKEGLVKLADFGVASRTTGLSESSVVGTPYWMAPEVIELSGATTASDIWSLGCTVIELLEGKPPYYNLQPMPALFRIVNDDHPALPQGASPAVKDFLMQCFQKDPNLRVSARKLLKHPWIVNARRSDSVVPKKSTEYEEAVKSVQEWNEALRSPDTGTLRKPYRYDTQGAAPLRPDMAPSRYTPTKDILPSPVSKHVTDRFRSPDSTEEDNWDDDFATAISPSALQLPHLRPQDNFGGMLSSEKLKAFASLDGTVLRSDDGFDDFDDPFTQQPGESDPLRTIRPYSAKPTGENMPPQTKATISAMHPNVPILQTPVPPLRPQRPTSYFKENSVEDYSDLISANEDVLDDKLSAFQEIDEEDSDVSFPSPSKEVVRYQALPEHEEDHQPQLRKRISVKRHRSAIEIQKFAENERDEDFSDILGADEVALDKPESDESSDRSTLMLNSKLSNNSWLGDQDDEDDPFAQLEEGLDEMDLEANIARDKYARLRGQVEGLVSSLKTSQDEDVLGEISDQLLTVFCDLPETKNIIMSAHGMLPILEILDMCRRRDIVLCLLRIVNAIIFNDYEIQENLCFVGGIPIINEFASKKYPREIRLEAAAFVQQMYQTSTLTLQMFVSAGGLNVLVEFLEDDYEDERDLVLIGVNGIWSVFDLQGSTPKNDFCRILSRNSVLDPLSLVLSRVLDEEGELAEIVEGRIANIFFIFSQAENHVKVMVAERTVLHRVLKELKRMTPAHQITMLKFIKNLSMLSTTLDSLQNSNAIDVLTDLLRSTIKRPHFREVSNQILNTIYNMCRLNKSRQEDAALNGIVPLLQKIVKTERPLKEFALPILCDMAHSGKVGRRELWRNKGLAFYISLLSDPYWQVTALDAIFTWLQEETAKVEEHLLDNRYDKTSFTDSIVRCLTVSKANAFENILEPLQKLLRLSPPIASTFARPDLFMRIGQKLHHNKAAVRLNLLRIISSICDSSEEQGGLLAKYGLLEAIRELEHDPAILVRDMAGKLIQSNEKSEAFSLEKRKPGMRRKSTSTTPPGYLANQSAPATPQINRFSQPKAYFDGRESQRHPRPSLSSSALAMRPGSRDGTGPGLSAGLNGSAGPSRNRLSRGVVNRLSQVELLAEEESRPSSSLSRRRSILPQRRRPTHTDADWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5D8</accession>
    <name>A0A317X5D8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RSC complex subunit Sfh1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_353830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470577.1">
        <property type="nucleotide sequence ID" value="XM_025607120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5D8"/>
    <dbReference type="STRING" id="1450535.A0A317X5D8"/>
    <dbReference type="GeneID" id="37109263"/>
    <dbReference type="OrthoDB" id="10258327at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="407"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="567" mass="62906" checksum="C50F1B1806FA4CBA" modified="2018-10-10" version="1">MANMSPLRGYITSYPPRVRQYGNALLTPIIPPSQVGPTPRTTKRGTAAINYAEDGFDDEDFEDSEGPRRPTGLRSLRREESTFDKVPLAEKLGKEIHAPVEVQGVFRDWMIKRMLRPACADQLQIQAQLPLTLIPIRIDLEIPAHQPLEPFPLPRTILDPSINPTLPAYRRPEALPAYRIKDTFLWNLHEALATPEEFAVGFVRDMDLPNPQAMTMTISNQIRQQLEEYAGVALHPLFQSVQPKLPAPQAGLSRDVSATPVSAHAATPDSRANQVTVTKEPLVNDSILNPDDAYRCLINLNINLQNKLYTDKFEWSLLHPPGMAEEFARTTCADLGLGGEWVGAIAHGIYEAVLKLKKEVCESGGLISGMGGYGNEIDNQAANGAEAGWRYDPEGLGDEWEPKVETLSKEEIEKREGDRERQIRRLRRETARFSSTAGITPDTSRQGSGYFDVDSETPLGRGERSKRKKRFRSLSPLGRGGTPGGRGTPDTGSGAGYGGGGGTLSDWERQNWRCTNCMVWGTAVWAVRDGPAGQRTLCHNCGLLYERDKVAPEWSRDLHRHDMPIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5G7</accession>
    <name>A0A317X5G7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO94DRAFT_532771</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470580.1">
        <property type="nucleotide sequence ID" value="XM_025611191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5G7"/>
    <dbReference type="STRING" id="1450535.A0A317X5G7"/>
    <dbReference type="GeneID" id="37113334"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="15" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0811">Translocation</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="8 19" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="53"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="19">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00025261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PWY93819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="309" mass="34076" checksum="5C00D3A8855F28F1" modified="2018-10-10" version="1">MAAAQVISNSGHDEMIHDAGLDYYGRRLATCSSDKTIKIFEIEGETHRLIETLKGHEGAVWCVAWAHPKFGTILASSSYDGKVLIWREQHQNTTSPVGGGAWTKVFDFSLHTASVNMVSWAPHESGCLLACASSDGHVSVLEFRDNSWTHQIFHAHGMGVNSISWAPAATPGSLISSNPGPGQQRRFVTGGSDNMLKIWDYSPETKAYNLTQTLEGHSDWVRDVAWSPSILSKSYIASASQDKTVRIWTSDASNPGQWTSQQLEFDTVLWRVSWSPSGNILAVSGGDNKVSLWKENLKGQWEKVKDIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5R2</accession>
    <name>A0A317X5R2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c oxidase-assembly factor cox23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_451141</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470426.1">
        <property type="nucleotide sequence ID" value="XM_025607540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5R2"/>
    <dbReference type="STRING" id="1450535.A0A317X5R2"/>
    <dbReference type="GeneID" id="37109683"/>
    <dbReference type="OrthoDB" id="9971592at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033108">
        <property type="term" value="P:mitochondrial respiratory chain complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051040">
        <property type="entry name" value="COX23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46811:SF1">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY93665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="70" mass="8388" checksum="5C58841FB2F1AA03" modified="2018-10-10" version="1" fragment="single">QQPSSSEQSQTNAWERVERRFTSKPASEYFDPCQDFADRSLKCMKRNGFDKEMCSDYFQAYRDCKKQWVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5Y6</accession>
    <name>A0A317X5Y6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_317310</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470787.1">
        <property type="nucleotide sequence ID" value="XM_025606875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5Y6"/>
    <dbReference type="STRING" id="1450535.A0A317X5Y6"/>
    <dbReference type="GeneID" id="37109018"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="136"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY94026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="559" mass="63620" checksum="E54FFB8FAA84EC16" modified="2018-10-10" version="1">MARVIRGEGDSLQQRGQLLFRQGNYQDALSAFTEALHCKGADVMGILDNRVATYIKLKQYDRALTDSRQMIKRDEKDLDGRGVLRYGQTLLLTGDYKRAQKAYGWGLNKLPMENPRRKTVLQMFCKVRDRASVKRLDPFAVLPLELAMMVLQHFTFRQLAVLLRVSKGWQRMLSQPDLWMQLDFTEARRKVQWRSFRAFVQRSRAMLTHAVMTNISTPFQDKVLEYLGRCPKLEHLEIRDPINQPAGLYDMFRGSTQLKSLVIGKQTPVAQEYIAKFLTSLPQLERIEIQNAQPSAESKVQWPSHLPNLRSIALLTEASIPPPGRVAALYIPPASEGMSCSMPNLEEIRLDSYPRVWAPYYLSFDPIQFPRLRRLDLKGVYIGLFSLPPSLEHLSIHAGAAPTGNEFPFHGEYPPHLPNLHTLRFRDLLWVTFYTLHSIIVDAKAPLRSLMLDRCPALMPEKLHFVLVENSINLTELGVSQLPGLNDTTVKSFVESMSNLTALDISGTDVTGRSLKMLADARSSDSDLPQIEHLYVRNCDNVPLEAITYARSHGLKVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X678</accession>
    <name>A0A317X678_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_532041</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470844.1">
        <property type="nucleotide sequence ID" value="XM_025611035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X678"/>
    <dbReference type="STRING" id="1450535.A0A317X678"/>
    <dbReference type="GeneID" id="37113178"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="9">
        <location>
            <begin position="192"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="10">
        <location>
            <begin position="310"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY94083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="356" mass="40213" checksum="3290920A2DF92EF9" modified="2018-10-10" version="1">MNPGKLADGDSAKHPKKLIFAPGDIQATTDPKTTPTPSLDASTAPAPISRLAAETLRSNASTPDSVTENDIVSHPARAHQFVSNPPLTISQMHPTNPLHQFHSWFCDPRLLPSSAPETCTLATASMPTGRVSARVVYLKELDERGWVVYSNWGSREGKGGQVFGNHADGEDTLSAMPEPGQDESLQEGLQQGNKWAALTFCWSNLERQVRIEGLVEPLSREESEVYWRTRERGSQIGAWASWQSKVLWSMEPQILIDRRRKSLDPTLRPQIPVDVDETDIDDGRALLEKRVREMEERFAGVEHIPLPPYWGGVRLVPESVEFWQGRRSRLHDRFRYVRVHAEDESAYRWRIQRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6J0</accession>
    <name>A0A317X6J0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA mismatch repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_532712</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470532.1">
        <property type="nucleotide sequence ID" value="XM_025611177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6J0"/>
    <dbReference type="STRING" id="1450535.A0A317X6J0"/>
    <dbReference type="GeneID" id="37113320"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="680"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="939" mass="104251" checksum="0C4F64CCD53742E8" modified="2018-10-10" version="1">MSSNDSKIQPLPPDVVAKLKSSTAITHLNGVIVELVKNALDADARIIYVTVDFLRGGCVVEDDGDGIPPAEFEPAGGLGKAHHTSKYHTSQSVYGRRGLFLASLSALSLLTITSHHARHPSTNTVTFHHSTPVARLMPVPVYQELRFSNHGTSVTVNDLFGNMPVRVKSRALALQRPDELVRQWDELRQLLVSFMVTNDRMVKLVVSDLHREKRLIVHPQTRVRPQGGELDLQRIRSILAQSGLIEAQNTGIWDVVSASVADFAVHAAISLIPSPTKKVQFVSLGPDPVFARNNANLIYTEVNRIFSLSDFGTIKGSSSFSKSGDGADGESVHSKPTSKAVNKWPMFYIRINTRDAWGIDDEGQDLPDSERSLQRIIDVLATMMNEFLKQRGLRPRARKRTRGTPGIPPATTSPSNLRAKRPLSPECAASSTEEAFRDQLKLPSFRKSSKTSHHFGDWTRIKSAKKDTTGKRLPLRNLESDSTPQSDNNPLRIVKDHLDQEPALPSEQGGNEGSTIEPISRRQELGMRKEVPNGDQEASEVDTMIPWVDPYTGRSHLINSRTGQSLLIGPSVELGLTLRPRSTGSLRAPNLALDGVKRPRSAALGRTENKWVENLLDNWVNPVFGRPEKPISAMDPSGHEATRPGSSSHDNRSAQCRLDNMGVSKFRGKLRKQDLRTAEIIAQVDQKFILTKMQTSPSHPLGDPTSSLILIDQHAADERCRVEHLLAELFASSDSPDRIQTIQLEPIIFEIPATEASLFGRYREFFQSWGVDYTVEQGPGDINVFIFVSTLPTLIAERCRAEPHLVTDLIRGEIWRREEENGRSRQGLPAGLGDRADMEWDKRSWVDRLDGCPRGIIDLLNSRACRTAIMFNDVLDSDECQSLVRRLADCVFPFQCAHGRPSMIPILDMGAMLDQSQSDEYEGPGFVDAFKGWQDGKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6R0</accession>
    <name>A0A317X6R0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Inactive metallocarboxypeptidase ECM14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Inactive metallocarboxypeptidase ecm14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_512274</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Inactive carboxypeptidase that may play a role in cell wall organization and biogenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469998.1">
        <property type="nucleotide sequence ID" value="XM_025609805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6R0"/>
    <dbReference type="STRING" id="1450535.A0A317X6R0"/>
    <dbReference type="GeneID" id="37111948"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03860">
        <property type="entry name" value="M14_CP_A-B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000060">
        <property type="entry name" value="Putative metallocarboxypeptidase ecm14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF147">
        <property type="entry name" value="INACTIVE METALLOCARBOXYPEPTIDASE ECM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016395864" description="Inactive metallocarboxypeptidase ECM14" evidence="17">
        <location>
            <begin position="22"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="18">
        <location>
            <begin position="200"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00026213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY93237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="599" mass="67113" checksum="425B25D57450499E" modified="2018-10-10" version="1">MMRHLLSLLVLLVASAALVSAVPAGSIITPQPPVEPVHLLSSRPSDPKRPWIRLRDWIIESIWGIDKPSARQFPLNESPRGRAPPSRVLARYGSDVVLRFNLRNEDEAEALAQAADILFLDVWASTPAFVDIRLAEEVIPSLLGLLPDSLQTAYTPLMDNLAEMIYTSYPTRKPIGLEGQSGFAHSGRSAAHFGDLFFHEYQPLTVIIPWMRLLASMFQSHVRMISVGVSYEGREIPALRLGAGSSTATSGPRKTIIVAGGSHAREWISTSTVNYVMYNLITKYGKSKAVTRLLQDFDWIMIPTLNPDGYVYTWDTDRLWRKNRQQTSLRFCPGIDLDRAWDFEWDGDRTRSNPCSENYAGDEPFEGMEAQQLARWALNETQNNNANIVSFLDLHSYSQQILYPFSYSCSSVPPTLESLEELGLGLAKVIRYATHEIYDVSSACEGTVTSGAADGNPGRLFPIGGSSGGSALDWFYHQLHATYSYQIKLRDRGSYGFLLPSEYIIPTGKEIYNVVLKVGSFLVGESSFESDLKAELYDLETETDPDILINSNNHASFSTHSLVDTQKANDPLSDLDDDEWDEEVESEYRTAEHLFEFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6U7</accession>
    <name>A0A317X6U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_582314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470652.1">
        <property type="nucleotide sequence ID" value="XM_025615471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6U7"/>
    <dbReference type="GeneID" id="37117614"/>
    <dbReference type="OrthoDB" id="4386154at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10493" checksum="0DF53363C759EC53" modified="2018-10-10" version="1">MPQDAKNAFYSVGYLKDLKARYEAATSDPCRGLTFEDALEHVNSTGRKNFSRDDVKRFDDNHDDNINFAEYLAMMLENDEQMAFQNAKFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X755</accession>
    <name>A0A317X755_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_553330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471140.1">
        <property type="nucleotide sequence ID" value="XM_025613651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X755"/>
    <dbReference type="STRING" id="1450535.A0A317X755"/>
    <dbReference type="GeneID" id="37115794"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000232">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="107"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="227"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="390"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY94379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="493" mass="52515" checksum="DCB789A4BD54C263" modified="2018-10-10" version="1">MSPSAFDDTDHAQRERSRSPRRRSRSPRRSRRSYSPRSRSRSRDDYRRSDRRSRSPMSTTQGPSGGHSASGYGGRSSYPPPPRSFEDRAVAKEQMMQAVRESSQQDRRVYVGNLSYDVKWHHLKDFMRQAGEVIFADVLLLPNGMSKVGANAIVEYATRDQAQNAVNTLSNQNLMGRLVYVREDREPEPRFTGGPSRGDFGGPGRGGFGGFGGPGGPGGPPGGAGGRQLYVSNLPFNVGWQDLKDLFRQAAQQGAVIRADVHTDATGRPKGSGIVAFESPEDARNAIQQFNGYDWQGRALEVREDRFAGAGPGFGGRGGFGGGFGGRGGFGGRGGFGGGRGGFGGGFRGGYSGGAPGGYPGGGGPGFEGMASVPPNPFTDFATSGGDKGAVIYVRNLPWSTCNEDLVDLFSTIGKVDRAEIQYEPNGRSRGTGVVQFDNGETAETAIAKFTGYQYGGRPLGITFVKYMNAGPGPGEPMDGTEPTAPITQDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7B3</accession>
    <name>A0A317X7B3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_457164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471190.1">
        <property type="nucleotide sequence ID" value="XM_025607733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7B3"/>
    <dbReference type="GeneID" id="37109876"/>
    <dbReference type="OrthoDB" id="10563235at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="70" mass="7752" checksum="B56B9E083EC5429C" modified="2018-10-10" version="1" fragment="single">VGASTSSVRTWPSHAPLTSLVAPIFSATDHLRRSVMLHWHVPGLTISPPELDNEHNSWASWVHSSWATLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X834</accession>
    <name>A0A317X834_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470573.1">
        <property type="nucleotide sequence ID" value="XM_025611190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X834"/>
    <dbReference type="GeneID" id="37113333"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="163" mass="18060" checksum="05871F33C2A3A39C" modified="2018-10-10" version="1">MIDNCPRPVVSARFVSNVVFHRQRSRRTPTIPSWLPGSGPRSRVSRRGSGTVVVVVQDNFWKIPTTSLSKQTNQLPSQWAPFGQLLRARSSSSPAPTIYLEATYLSKHYYYSAGRIRPVSASVHSSPRRSESITTQCSIKGLLTSESSPSKTRGGVPPYQPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X885</accession>
    <name>A0A317X885_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_487264</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470548.1">
        <property type="nucleotide sequence ID" value="XM_025609030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X885"/>
    <dbReference type="GeneID" id="37111173"/>
    <dbReference type="OrthoDB" id="10544325at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="66" mass="7427" checksum="4784CFC828DD33B1" modified="2018-10-10" version="1">MVFGSSLPFALCPLDFRLLARTAHCPRSISLSSTPDGRARLLEVRRRWSMALPSRVDPGTRNILFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8N4</accession>
    <name>A0A317X8N4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_582034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471406.1">
        <property type="nucleotide sequence ID" value="XM_025615450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8N4"/>
    <dbReference type="STRING" id="1450535.A0A317X8N4"/>
    <dbReference type="GeneID" id="37117593"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="392" mass="44309" checksum="BCB3DA051CFB0EBA" modified="2018-10-10" version="1">MEPPIPSKPLFRGHTAAIGDWPLELCLHMEECLGVSVKQFVLLRSDMSFYRLLQVEAILSEDRALVGFPLEIYRCRYIGGRASRCLFEPCTSEAAPRLMRDGNCKGLQHLLDNGMDPCVYSTSEIPLLALAVAHMQLECVRLLLHYQANPNQTGYWRDARPLDYVLPHCLSDSYPTQSTIIEVLIEAGGTFTFANVIDTICVDNRLDLLHQAVCNGTKIRDLSFAYGATALHRAALNVRGGPEIIDYILEQAPELLNARNTAGHTALQYALWNPNRIVAMHLLRYPIDLYALDVTKESALTTAIGYNRMDIVDAIMGRKDLDMLQLHRDIPFHQTPLGRAITTRNEELLDFLLSYPRMHVPKSARDLALDQTRATFKLHECWIPMIERLPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8Q5</accession>
    <name>A0A317X8Q5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_530837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471700.1">
        <property type="nucleotide sequence ID" value="XM_025610764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8Q5"/>
    <dbReference type="GeneID" id="37112907"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="100" mass="11275" checksum="28157A651041BB0C" modified="2018-10-10" version="1">MNSDSTDSDTSTPDSIHDKCGDKSATTHSSTALVDTAYLFFQKSYGVMVEELSWRKSRIRSPINERRDKRGVEVLCSCWAKIMALCCTTIMYYVHNAVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8V1</accession>
    <name>A0A317X8V1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NIMA interactive protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_485677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ADIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470788.1">
        <property type="nucleotide sequence ID" value="XM_025608986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8V1"/>
    <dbReference type="STRING" id="1450535.A0A317X8V1"/>
    <dbReference type="GeneID" id="37111129"/>
    <dbReference type="OrthoDB" id="312015at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47057">
        <property type="entry name" value="AFADIN/ALPHA-ACTININ-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47057:SF1">
        <property type="entry name" value="AFADIN_ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY94027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="581" mass="64399" checksum="577DE0F016920AAC" modified="2018-10-10" version="1">MEPQNLEAASTYINNVLLARGLLKSGRPIEFANPEDEDGGSAATMGRIINLVNDLVLRRDREAEHRENLATTIRTLRVEESQKTAELEKVKTKASELTRSLALAEAQERALKSNVSSADATIRGLKEQVQRMKTTMQQVRAQCANDIRKRDLEMQKLKSHLAERQRGRREGLAMTTININPAATQSSRSRLAAGGEGINDPGYSLKQETNDFLTELCQTLSDENDTLISLARNTVETLKDLQGLSQAEEDDKYSTGAASVGPSRSVQGSVTALPTSCDELSTQMDHVLEHLRTLLTNPSFVPLEEVEMRDEEIKRLREGWEKMEGRWSQAVTMMDGWHKRIADGGHSVQAEELRRGMDLDLHLDIATALSKDGEREPTIQSPIFEDQQAEEEEEKAAAKITTEDTRRSPSPKKAPRSTRETRSKRLSQALKERSDNIMTGRSPRKVSFTTGLQDSPCVSSGTDETLQVKAHQSEAVTRRSSRRKPESKFLSRPGGSGRSPQPKESRLATAAPVSTSQARLSVPQKLAAVESEARAAEQARKESESRKRGRALKGSSKGHRDRRRSTLTSDELGELMGMPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X901</accession>
    <name>A0A317X901_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_531719</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471546.1">
        <property type="nucleotide sequence ID" value="XM_025610961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X901"/>
    <dbReference type="STRING" id="1450535.A0A317X901"/>
    <dbReference type="GeneID" id="37113104"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="6">
        <location>
            <begin position="26"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="280" mass="30948" checksum="3259B131174C205D" modified="2018-10-10" version="1">MAANSLYNIYRLAVPATIGFSLLGSSIYDVRGGTRAIIFDRLSGVQEKVMSEGTHFLIPWLQRAIIYDVRTKPRNISTTTGSKDLQMVSLTLRVLHRPDVPKLPAIYQSYGIDYDERVLPSIGNEVLKAIVAQFDAAELITQREAVSNRIRTDLMKRAAQFNIALEDVSITHMTFGKEFTRAVEQKQIAQQDAERARFIVERAEQERQANVIRAEGEAESADIISKAVAKAGSGLIEIRRIDASKEIATTLATNPNVTYLPGNDGKEGGKSTSLLLGLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9A4</accession>
    <name>A0A317X9A4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_323616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470948.1">
        <property type="nucleotide sequence ID" value="XM_025606919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9A4"/>
    <dbReference type="GeneID" id="37109062"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="150" mass="17435" checksum="DBBB98B18CFADC8B" modified="2018-10-10" version="1">MDVHTIIYHLHTYIDSMKINAVYQLTTTTLLTLLSSSSSPLIPNHKQRTNPIPQPRRSPKIKFKSQISSAYLVLHRTPYTQWYIHTPIHRYFPTHPPTLHPHRRTGNGCCHTHLHPPPQLQFPATSRYPGRISFWKKITCGLDYHLPSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9N6</accession>
    <name>A0A317X9N6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_450244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471113.1">
        <property type="nucleotide sequence ID" value="XM_025607536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9N6"/>
    <dbReference type="STRING" id="1450535.A0A317X9N6"/>
    <dbReference type="GeneID" id="37109679"/>
    <dbReference type="OrthoDB" id="4480493at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29035" checksum="02DF981B17EF7F38" modified="2018-10-10" version="1" fragment="single">SIADQPQYSPPSLISHPLPQLPKFPKLYIYDGDNATALAIRQFIHERGGVRIRSGLLDVQPKDQVLPLLVHEHDYAGEVPILYLDHPARRPVEKVFGFGPITEYVDSVAVGGRKLYGDTAQDMAVVRSLIYCLNRDVVEPLYGWNNNRPGNGSGEEVTGLVPVPSRQEVLKRRVLESLEKMELDFLEQGKGGYLLGRSSAADVFFFSLVVAHGDRWDWFFDDDPRPRITQYFDRVRQRPMTGFAYEFWDTEAANVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA91</accession>
    <name>A0A317XA91_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vanillin dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_530208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472245.1">
        <property type="nucleotide sequence ID" value="XM_025610633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA91"/>
    <dbReference type="STRING" id="1450535.A0A317XA91"/>
    <dbReference type="GeneID" id="37112776"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000012">
        <property type="entry name" value="NAD-dependent succinate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF6">
        <property type="entry name" value="CYTOPLASMIC ALDEHYDE DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY95484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="435" mass="46114" checksum="E2D827F555919BD1" modified="2018-10-10" version="1">MIAKNPNANYAIIPLIINNESVVADTIFDITSPATGEVIDRCAGATVDDANRAVAAAKAAFPGWSSMKPYDRRDILMKAADVMLSRKEELIRYQMEETNAGRSFVEKTFKMGVTFLKDFAARIPSIEGAVPSVSEDGECAMVIKQPYGVVLGIAPWNAPYILGTRAVALPLAAGNTTILKGSELAPKCFWAIGDIYREAGLPAGCLNVLYHRTSDAAAVTNALIAHPAVRKINFTGSTTVGSIIASTAGKYVKPVLLELGGKASAIVLDDANLEKAALACAQGAFMHSGQICMSTERIVVQRSIADRFKPLLADAVEKLYGKQGPAFGLVAPAAVKKNKELVEDALAKGANLVYGDLAAVELDNSSMRPLVVGDVAKNMDMYSMESFGPTVSLIVVDSDEDAVALANDTEYGLTSTVFTGNLFRGLRVAKQIEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAH6</accession>
    <name>A0A317XAH6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_582021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471393.1">
        <property type="nucleotide sequence ID" value="XM_025615448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAH6"/>
    <dbReference type="GeneID" id="37117591"/>
    <dbReference type="OrthoDB" id="4423022at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016266514" evidence="1">
        <location>
            <begin position="20"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="116" mass="12190" checksum="F47BCE63B891CBC5" modified="2018-10-10" version="1">MKSVLSKATLLALPTLALSSPLVSYAGYYFTNCTSPSVTATNVAASYCVNVENIPIKSFTAYVFSGACDDSTTPVLNTYTEAGCAADSLFETVDVDSEKQCFEADVTLVSLGVECV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBD6</accession>
    <name>A0A317XBD6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_581099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472705.1">
        <property type="nucleotide sequence ID" value="XM_025615370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBD6"/>
    <dbReference type="GeneID" id="37117513"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="296"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="379" mass="41356" checksum="909B4B4F4F2ACEC7" modified="2018-10-10" version="1">MAVDPAIVAIFGSPPSNLDLADSRVLVDNAVAGVILSLAVISVLLRFVARHLLRNPLKADDWVIILALVFIFTTTGLCISGGFFGAGRHVWAMSIPDVVTLFKILFVYVLVYAAVCASAKLSILFFYRRVFLASQGDLSLRLSIYLGFFLTISYPIIIWVTMATACRPTSYFWTQFSGATGSCIDTNTFFLALGIINMLNDVIVLLIPFPQIAKLHMNRRKKLAISGILAVGVVACIASIARISAVDEFTKRTDITWTLGPVFIWSTVEPGLSIVCACLPHLAPLVRLAHIKLSSSQDSKPSRPTHQSTPWRSRSGHAAKPSPKNKFNLSGYDDEICLTNHVTTSTSLRKQQSIESVTEGNQVQAIVVHSSLMQSVSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBJ6</accession>
    <name>A0A317XBJ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_581101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472707.1">
        <property type="nucleotide sequence ID" value="XM_025615371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBJ6"/>
    <dbReference type="STRING" id="1450535.A0A317XBJ6"/>
    <dbReference type="GeneID" id="37117514"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="344"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="544" mass="60870" checksum="366DF68E2DAE8BCF" modified="2018-10-10" version="1">MATPGLLWVTMHPRPSLPAAQFHDWYNTEHGPLRLRLPFCTNGFRYRATDEEEPEWVALYDITDMVEMTRETYLALRGDTIKTPREKATMAQIAVDRRLYDTVLEQKAADYKALEDTPDTEAAGSVLIAISLTLSDAAHEDDFTRWYAEEHIPMLTRVPGWRSSRLFVTAAIDPNAPREYLAVHEYRAQNGLGGPEHKASLETPWSKRVMTEEVAKARRRVYQWAYTFGPAPRELSSLASPDVVGPWSSIDGRTRTFPSPTRPAVESFVTTPDGVDLPYRLEGSTDPHSPVIVLSNSILVDYTIWDDFVDQFLSDPRNQNFRILRYCTRGRLQECGEKPVNIDLLASDIIALLDALRIPKATLIGVSLGGVTVLNTSLLYPDRVTRFISCDTNSSSPESNRKAWNDRVAMAEGEGAVSTTTQQTIVGEQLAEITVRRWFTPESYETQPHLPAKAKELVRTNSLEGFRRSVQALCAYDVRDRMAQAQVPGLFVAGDSDGVLPKTMQQMAADLKGDAELKLVPKAGHLPMLENATAFTAVVNEYLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBU0</accession>
    <name>A0A317XBU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">succinate-semialdehyde dehydrogenase [NAD(P)(+)]</fullName>
            <ecNumber evidence="6">1.2.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_530784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>succinate semialdehyde + NAD(+) + H2O = succinate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13217"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate semialdehyde + NADP(+) + H2O = succinate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13213"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.16" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472865.1">
        <property type="nucleotide sequence ID" value="XM_025610749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBU0"/>
    <dbReference type="STRING" id="1450535.A0A317XBU0"/>
    <dbReference type="GeneID" id="37112892"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000005">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00050387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00052698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="438" mass="47207" checksum="9840198EC1A11BC2" modified="2018-10-10" version="1">MTQAIVAADKALASFRTTTARQRARWLRKWNDLVLENIDDLALIVSLENGKALPEARGEVMYGASFLEWFAAEAERAHGEVIPAANPNQRILTVKQPLGVAALLTPWNFPIAMITRKAGAALAAGCTTVWKPAGETPLSCLALAVLAHEAGLPVGSINVVLTLNKVAEVGQALCEISVVRKLSFTGSTRIGKLLAQQCIQTLKKLSLELEGNSPFIVFDDAKIDHAVEALVMAKFRNSGQTCITANRVYVQKGIYNQFTEAMLKRMQTLQVGPGTQDGVTIGPLTHERAIDKAMQHIEDAKRHGGQVLMGGAPLPELTGYFMQPTLIRDMKPEMITTREEVFAPVLGLYPFETEDEVIGLANASNVGPGGFLMSENISRCVRVAEALEVGMVGINVGMLIACESPFGGVKESGYGREGGKQGIEDYLTVKSILLGVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCF5</accession>
    <name>A0A317XCF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_541898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472562.1">
        <property type="nucleotide sequence ID" value="XM_025613067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCF5"/>
    <dbReference type="GeneID" id="37115210"/>
    <dbReference type="OrthoDB" id="4509827at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="110" mass="11689" checksum="B4758A0EEFD08B45" modified="2018-10-10" version="1">MTLEVGTVSLLTSDSLVATESGSYAAAEIPATIYHWTGPRRRSSPDFLESEIGLVASPQHVHPRASWLADGVPWLVLVSTRTQVNLEILPGPGTISEPMVGGKPSCEHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCJ3</accession>
    <name>A0A317XCJ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_6643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473097.1">
        <property type="nucleotide sequence ID" value="XM_025617586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCJ3"/>
    <dbReference type="STRING" id="1450535.A0A317XCJ3"/>
    <dbReference type="GeneID" id="37119729"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="712"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1193" mass="132615" checksum="4A8C7283A30C901E" modified="2018-10-10" version="1">MRRTMTELTLNVPRHRTSGWLPRTLRRQYLVPLACLMFVMLLLTEFLRQLGNDKGSLSLFTSTDQITDTRRFAYTYVPTILSMIIAILWSLVEYDALRLEPYFQLSKPQGASADVLLLNYEFGHYTTAPFFAMRNRHWIAVCISILSILLQLVFPSLQSSLFKMDDATVYNNQHLETWPDLVNLAEQGALADNDNLNLTGAGLRDHRDLAYNQPQSSKYAMAPVAIPLDVQYDTKLWELTQSIYWAELSCAEVEVSDAITLEVSSNASSFGIGSPNSQPSIWNLNEVPSTGQNCSLELIEEIIIPPTNGSLQISHWQPSTSGVSVTEQCASFDIIGVTVDISLNKSSEHVDRQKSDFSSSDYTHQVSGFGCKIVYQTSQAGISVQVNGSLSIADLHPNSTTEVSEASLNTTHFKGIILQEVASTNGTSASNKKPVRPSTLQRDLMSKLELSVQGAFVPLMNRIFDISGQSHYVKASHVTHQMAIIVGPVQSFVSEAILLFGVAVVLYLAYTYPRRPNMLRSDPASIASMCGIMADVIDASCLSHLNLDELSTRQLRTILQNYTCRWQRAADPPRICIEPSAVPRSQRQIFQGKSDPRPHFLLIPIFALEIFLFIAAFAGIVTIFVLCAKDGAFHSLTYLDSDSLAALFQLIPSAIASIIRAICLSIYRYLSVLEPWSVLQAGGASAASSLLLEYGSLNPLASLFRWFSYRHILLGLVGVACMFNTAMNILASGLFQHELGPTRADTDMKSNYSYESFAIRQPSSLVPELSTIKSSIYSGTSLLSWTTSTYSFLPAWTDTSSEWLVGGTIRGVGADLFCKELSIADSYSEDSVSNVAHWQYSPFNESDTVCQINTIQTSETSQEESLTVHFFASSTSDETNGCQKPAVLVVAYPSGSGYLQTTSENAVALYCESQLIMQNFSVGFNSDGYIQYYVPLNGTSVVDEPILQNGSTNLANYNLRLSSPLSVTYNGSHQETNNASDADWFGALTANLYRILDTNTTVVTADVLEVASRDVYRTIFATDLSLERDAYFQYQDPPSHINDGIIYNMSWAVVPSLASFIYVLLIVLFDGCVVASVFFTRRGRFRFPRIPRSIGSIIPWVIHGRVLNDFKGTYAWSEGEREKHFADLDKRYKLDKHEMPDGKWKYILEEDVSRRDSEPPTGEILQSTTTSKSRFQTLLRRVTSDFDKKDQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDR2</accession>
    <name>A0A317XDR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative Ran-specific GTPase-activating protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_620249</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472643.1">
        <property type="nucleotide sequence ID" value="XM_025616918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDR2"/>
    <dbReference type="STRING" id="1450535.A0A317XDR2"/>
    <dbReference type="GeneID" id="37119061"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000254">
        <property type="entry name" value="Ran-specific GTPase-activating protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="104"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="YEATS" evidence="5">
        <location>
            <begin position="224"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY95882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="460" mass="51610" checksum="8ABA0441D336EF89" modified="2018-10-10" version="1">MSDVAETKPDPAISAPEGAEKAEETTTNTAETKPEETQSATETAAETVKDAATKTTDSVFSMFGGGPKKEKQEEPEDAKDEPSGSSKAQKGEDEDEAPESPDVHFEPVIRLTEKVETKTNEELEEQTFKMRAKLFKFDRDSKEWKERGTGDVRLLKHKENQKTRLVMRRDKTLKVCANHYIVPDMKLSPNVGSDRSWVWNAAADVSEGEPEAQTLAIRFANSENANLFKDAFEKAQQENEKLLSQNKDSGVEGFPLRSWSIEIYVVNEHGEQVPANVFDKVTYTLHPSFGERAVQVFKNPPFRISEEGWGEFDMQIGLTAADKEHFVTHDLNFAQPRYESKHVITFKNPKPALLAALRESGPVPGDENGVKSKRSAAGEEGSKKKKRMEKSVDMDKLADGLQRLGEDDLLQVVQMVHDNKAPDSYTKNDVEQGEFHVDLYTLPDTLIKMLWDFTQEKGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDS9</accession>
    <name>A0A317XDS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alpha-1,6-mannosyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_13256</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473246.1">
        <property type="nucleotide sequence ID" value="XM_025605658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDS9"/>
    <dbReference type="STRING" id="1450535.A0A317XDS9"/>
    <dbReference type="GeneID" id="37107801"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016373935" evidence="12">
        <location>
            <begin position="27"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY96485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="359" mass="40695" checksum="E6048DCF8407BED7" modified="2018-10-10" version="1">MLTFRKSLFAAVLLITFIVYLRSSHSASSLPSPDSASAGNIYNEDQPKSDQKGGDKDTVQQLPLMPPPTAPLRDRLRYHFPYDLEAKFPAYIWQTWKYTPSSMFFSESLRDPESSWSELHPGFVHEVIPDDTQRHLIKYLFGAVPDVYEAYDSMPLPVLKADFFRYLILLARGGIYSDIDTTALKPASDWLPSELDLATVGAVVGIEADPDRPDWHDWYARRIQFCQWTIQAKPGHPIMRDIVSYITEETLRMKKAGILKTGKMDKTVMEYTGPGAWTDAVFRYFNNPDYFNIEPGSTLNVTYEDFTNQQGYKKVGDVVVLPITSFSPGVHQMGAGDIDDPMAFVKHHFGGTWKDDPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFK3</accession>
    <name>A0A317XFK3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_16679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473383.1">
        <property type="nucleotide sequence ID" value="XM_025605908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFK3"/>
    <dbReference type="STRING" id="1450535.A0A317XFK3"/>
    <dbReference type="GeneID" id="37108051"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="250" mass="27600" checksum="7BC865E86805D463" modified="2018-10-10" version="1">MAPLRIAVLECDTPVEKVNIKYGGYRGVFSLLLRESAAALGQSEKLDPETGLEISGWDVVTAQEYPNLEDVDAIVLSGSKHDSFEDHPWILKLVEYTKKAFEDKRVKIFAICFGHQIMARALGARVGRNTAGWELAVCEVDLTETGKQLFGRDKLRIHQMHQDVAYGYPSEVVSLGASPKCAVQGMYVPGKLITVQGHPEFRGDIMTELITLRTATGLFSKEQSEDALGRAGIPHDGIAITMAFLKFFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGE2</accession>
    <name>A0A317XGE2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Inositolphosphotransferase Aur1/Ipt1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_453699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473099.1">
        <property type="nucleotide sequence ID" value="XM_025607577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGE2"/>
    <dbReference type="GeneID" id="37109720"/>
    <dbReference type="OrthoDB" id="2566866at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF16">
        <property type="entry name" value="INOSITOLPHOSPHOTRANSFERASE AUR1_IPT1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Inositolphosphotransferase Aur1/Ipt1" evidence="7">
        <location>
            <begin position="118"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="322" mass="36888" checksum="635C0B11D3E5E38E" modified="2018-10-10" version="1">MGGLKNILEPAAIVAAFTAGTLINRRKNSKLLTTPDVESPLLEAPPEDLKPSDEGADERTIRNRRTIQSRILAKFPFLLEIWYWLLTYWVYQGLRAFSARMISGHKAIFDTAERHALSILSFEHFLHIDVELAVQRYILGQKPWLMAFLARVYYSHIVLGVIFVVYCYTFMQCDKYQGIRRTLAFENVIAFTILTLWRCMPPRLLPEEYGFVDVLHSNTGGSAWTQNKFQLTIAAMPSLHFGNSLFIALCLLKFSPHWYLRAIAPLWPMLMGLTIVATANHFILDAVVGACVTLTAFRFNYIMLSLLPVERALFRLLRLEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317URY5</accession>
    <name>A0A317URY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_357028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000068">
        <property type="protein sequence ID" value="PWY64724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461309.1">
        <property type="nucleotide sequence ID" value="XM_025607140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317URY5"/>
    <dbReference type="GeneID" id="37109283"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY64724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17315" checksum="263618C5F47720B2" modified="2018-10-10" version="1">MLVATVISTMLSPPPSPSSNGAIPTSSLIQHPPMSPHLSVLFPTPLHSLLTPSSVENPTFLSRDPRFPTYHVPAFHDLIPLVPLSPHSPLPVSNATNPASPIPDLVPSLPPPPHPSLPPLPQQHPHPTPPNPPRPQPTPYPYPYPHPNPPPFSSTLFPPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXH8</accession>
    <name>A0A317UXH8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fungal-specific transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_579770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461549.1">
        <property type="nucleotide sequence ID" value="XM_025615289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXH8"/>
    <dbReference type="STRING" id="1450535.A0A317UXH8"/>
    <dbReference type="GeneID" id="37117432"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY66039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="65800" checksum="6A076E3F7EA856EA" modified="2018-10-10" version="1">MSGMQLSWQPGFSLSRKPVKRSRARRTRLGALGHADGPQKFEFVAEHPVRSQRGYCGGVEPTLGYEAGSKTDDSSLPLAHCSTTEHPAASDSPGTLFDQAAREIISSVGAPHHSLSDSALVGDGGSDLEALYRTTDPYTRSNAIQCTSLYPPELTNHHMQASEGGDMGHGAFCVGAGLAAVSELHIVLRSPTSVPPSILYSSLSRRFQPILDRYNREFCKIPLTANLRRNPFQYHTDLGMKPMFLVHAVMSLAGHHIESTSTLVHRHAALQLLRESLTTCSNMGQGYSMLDTIIILFSLDETQSALGNWRTHIMGAFGLVEAYGGIDKWITSARTQVQIGLLTWWDAITSLVNREDCIFPYAYFEAAVSNQNDQEWDYFSLCGCPPSLVEIVMQLARLGAEKRKASSLRYVNFDTTVILELERSLESWHYVSPEAAFQDEESLQQDLDSMHCSEAWRNGLLLYIHRMFQWEPGSSIPMHILCRARVVMDHVVACRDEGMMSRQALLPLFFAGCELRDLSSRRRILQLCSDWNERTRYYMFGTTIPLLKEVWAEQEAKGFENVWWGQIVDRQHSSDGHSPLQVRLCFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZX1</accession>
    <name>A0A317UZX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyamine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_478743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461953.1">
        <property type="nucleotide sequence ID" value="XM_025608708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZX1"/>
    <dbReference type="STRING" id="1450535.A0A317UZX1"/>
    <dbReference type="GeneID" id="37110851"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000653">
        <property type="entry name" value="Polyamine transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF24">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="73"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY67604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="528" mass="59226" checksum="4A0A943CA99C879D" modified="2018-10-10" version="1">MTEETHIGDLLATDQKHEISDSHRETLPLIVTEEEALARARTQPDVALPLRITFGPHDRDNPRCWGYWRKWYITLFVSMLNVVTTWSCGSFSSGATGIAEHFHVSTEVTTLCLSMYVLGYAIGPVLLAPLSEYFGRQPIYIVSWFIMSLFQMPLALAPNIGTIIVCRFIAGFAGGAPLTNTGGTISDLWERNNSGGPMAFYGLSSTFGPPMALVISGYIGLNLNWHWIFWIMMAITGGVWIALVLTIPETRHSIILQRKAARIRKQMEQEGLRSAATTTDLHADDRQGLHQLFGITLTRPFRFLFTEPITAFSAIYNGFLYGLVYLFNEAFPLVFGSPNGHGFNVGQQGLCFLGMAIGPIVAFALYPLQERYYLRRVAENEGRSVPEARMWMARIGSLLIPISLFWFGWTSYRSVHWIVPIIASSFFGAGLYIVILSILNYVVDSYQTYSASALAGVILVRNIVGAGFPLFATQMYEKLDYEWASSLLGFIAILLVPIPFIFFYMGRAIRLRSPWAREHFDSNEDSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2Z5</accession>
    <name>A0A317V2Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461861.1">
        <property type="nucleotide sequence ID" value="XM_025612916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2Z5"/>
    <dbReference type="STRING" id="1450535.A0A317V2Z5"/>
    <dbReference type="GeneID" id="37115059"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF242">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="63"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="293" mass="32444" checksum="E2D3D6A7C935DC0F" modified="2018-10-10" version="1">MFFLVYLYYKFLAVVIRKFLGPKREIKATPDDVYQIQSRDAGRTIKAHVYRNVSASTEPIPVLINFHGSGFLLPLHGSDDAYCRQMSRETDRTVLDVQYRLAPENPFPAALNDVEDVVKWVLGQPEKYDLRRVSLSGFSAGGNLALAAAANLFPADSFHSVLAVYPVIDLHTDPALKTAPDTSGRPIPARMSRIFDRCYTHTAFDTRDPRISPLYASADRFPGRVMIVTAACDNLAPEAEALAEKIAKEPGKLVVRQRMPGCNHGWDKAARAGTVQGDAREKTYAMAAAMLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3W0</accession>
    <name>A0A317V3W0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AAA family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_478080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462279.1">
        <property type="nucleotide sequence ID" value="XM_025608677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3W0"/>
    <dbReference type="STRING" id="1450535.A0A317V3W0"/>
    <dbReference type="GeneID" id="37110820"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="420"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY68964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="620" mass="70035" checksum="E326E9FF0D467E78" modified="2018-10-10" version="1">MADQTESTTAKSPTLQRVKTDLGNHSQRLLRVDQIKDRQIHFVKTAKAKPKPDRFSKTALVVRRIISRQGMVSHTEIDIRSPLLQDLFRDLFKGVDGLELNKTPPIAKPELLFWAAPDLVRIKEEEKQKTSPNKPLIDDIGTALRFVEEDYASQIISLESLLQEKQITWDLLWAIFPPREVIIAPRFGVMNEEQAFNMLTSGYEERANGQRYFSANGQHIKHDGQDFGSTTLPLEIDEFDGARSISSLNFYPIQHHEEESALRERLIARGRKYVALMKEPACRDYTILTAIKEVERANGDTVPEKFNALGRVMVDPPGFYLHNSSSDLNRPWVYAENKLNAVGLSDDQLLICASWISGFSFAQKAWCQLAVTGLSDVEWNHNAFKRLVMAENRRQLIHGLVKAHRQDDAVFDDIVVNKGKGLIALLTGSPGVGKTLTAEAVAEVTQRPLYVVATGELGIDPDEVDNRLGMILDITRRWGCVLLIDEADVFLSARGKDLARDALVSVFLRRLEYFRGVAILTTNRKSDIDQAFKSRIHFTLHYPDLDATSRQEVWKNFLTNVAKTSELSEFTADDLTALSRHPLNGRQIKNIVSCTVSLARERGKNITVEDMETLIDVMID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4H1</accession>
    <name>A0A317V4H1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinone oxidoreductase putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_612302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461822.1">
        <property type="nucleotide sequence ID" value="XM_025616663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4H1"/>
    <dbReference type="STRING" id="1450535.A0A317V4H1"/>
    <dbReference type="GeneID" id="37118806"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY67100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="336" mass="36460" checksum="282097E5B6174AE5" modified="2018-10-10" version="1">MKAVGVKNGKGDADALFIEDGIPDPVPVGNRVLVRIKAFGLNRMDIMQREDRYPYPLLPESGKIMGVEFSGIVEEKGPDCSDDFQMGDKVFGLAYGGAYAQKIAVSEKMLVHLPSTLSFEEAAGIPETSFTAIQAIHLVGNLQPGQSVLIHAGASGVGQSAIQIAKVGGAYQIFTTAGSDQKCDLCRSLGADFAVNYRSGEDFAEVIKRETNGKGVDLIIDLVGRDYFHQNMASAAMDSRMVLVAALSGSKVDDFDLRALLNKRIWLLATTLRTRSADYQGQLRDLFAEKILPHIKTGEVKTTVDKVYSWTQVTDAHKRLESNVNAGKIICVVNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7E1</accession>
    <name>A0A317V7E1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Inositol polyphosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_539750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462575.1">
        <property type="nucleotide sequence ID" value="XM_025612767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7E1"/>
    <dbReference type="STRING" id="1450535.A0A317V7E1"/>
    <dbReference type="GeneID" id="37114910"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001686">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000036">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="818"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY70284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1207" mass="134338" checksum="CACA09F0244671CC" modified="2018-10-10" version="1">MEGTRKEKDATDSAPIRPVSTLLSHFENLSHRRAPSAVTNGSRDPPSFLRTPEYSDDVRSSRASLDLPRPRSPWGSVPEIERSHSIVHNGIPARPSGSPGISPGRRQNRPMSMNLHSSPQLAPTLTVDSPRSPPRGFGADHEEDIRVSRSPPNASRESLPTIPQGVPSHRPTTPVTASFATDNKPGRLSPGSTDAVANGRESPSERKGKSVSLPPPANRAEKPKIPAKPAALSHHDTGSLAPRQERASSEDRISPFSTPPSSPEKASPKQQPATRAAPVSRSPSHRSPSRPVPGLPTHRSLEERSPAPPAGVFREPSFSQRRPIPEPPRETKPLMVQIPPRHSLPPEPLASAPLHRASMHDPHERPGLPPRQPSVARRGGPSPSRYSYQPPPESPAFSLPPPTPFRESRPLYRDELPTSTNVHRQPSFSRESRPVPPPAVPERPVVERQAVRPVPSEDEQAPDDAPVARTDYPDASIANRRPPLLKSGPQEIHTRYDTRLMDVCGKHVCTTGYITRVWDLTTGEQIMSLSHGETVKCLSLAFKPGAGLEDEGQRLWLGTNAGDLHEIDIATRSIVASRSYPSRREIVKILRHKKEMWTLDDEGRLLVWPPDETGTPNLQYSYHNPYDRVSRGHTFSMVVGDLLWLASGREVHIYRPNARDDVSFKVLSRPLGLQHTGDVTSGAYTTQDGGRVYLGHADGKVTVYSAHDFACLSVVNVSVYKINCLGIVGDYLWAAYKTGMIYVYDTATNPWTVKKDWRAHDSPVSGFLLDSSSVWTMNRLQVTSLGDDNCIRMWDGMLEDDWLESRMQTRDVEFCTFREIHAVIVTWNAGASTPGSVRTSTFIQDAIHPENPPEILVFGFQELVDLENKKITAKSLLLGSKKKEHGDKEHMSRQYRVWMEHLTRAINDCMPLEESYVLLHSGNMIGLFTCVFVKHKERQRIKNISATEIKRGMGGLHGNKGALLLRFVLDDSSLCFVNCHLAAGQSQTAHRNNDIAAILEAESLPAESSLATRANHYVSGGDGSMIMDHEICILNGDLNYRIDSIPRHVIIDDIRSNNLTKLLERDQLLASRRKNPGFRLRSFNEAPITFAPTYKYDVGTDEYDSSDKKRAPAWCDRVLYRGLGRVRQLEYRRHEVRASDHRPVSATFKLRIKTVLPTERAGTWESCQQEFQQEKRRLASEASIEYLITVLGTDPQQARGLILGNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V876</accession>
    <name>A0A317V876_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_540161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462347.1">
        <property type="nucleotide sequence ID" value="XM_025612850.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317V876"/>
    <dbReference type="GeneID" id="37114993"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="936"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1131"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY69032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1341" mass="150607" checksum="831BA9CF0D873392" modified="2018-10-10" version="1">MTRLRGASVSSYEVSRGGIDRPQFHRSKLPPNAPDVIAQNTIDVSDPAQVLLWCRDERRRQFNLLVRRYKNQLLYGCQDPGCQTPTCASYRKRVTDGPFRRYTELSARTLACYLASLDNAEDGLCRNLSRVPYELSPHDNQRRSKRRNRALPSNDSARERTESKEVGHTGTDEVSRSSPARDIGSPSSNDRNGRSPSPGLGSQDQELVIVEEDAPETQRLKDPKSFTQNLFDTLSLRMIEWLPLRRSPNTLGPDPGRLDIRPETRSPKPARDGTQPYSDKARPQLTRQRTPQHIIPTGGAPHTPSSRHVNGQTTALELRLPNQRVKRLSLTEVDQWRQNPRASSEEKSYQELKPARKLTVNTHVSGDELHNVPSPPALRHRPQKHRGRTGDGICVPSQEKQKKGRRVSWDGAKYLNNVLLDGPKKTEPPSDDQLPLEAQSPSDSKPKRRSSSRKRTISAIQSLTHLTGEIIDGMMQMMVVSEDEAERWRDELTYMESTGSFEESEWRFATPRQRQVFTFIAQSTFYALSNTKQLLLSFRQNTAGPSETNEDHNRPNLDLAQLQPSLHKLLRTCPRDIVFHSLWSATEAMFVPPKELSMPGKPARRSSQNSSATSTTPIIRRSDSGSSEQLTDSSAADIATVAMFALASSLPEIDASTWRTILRMRAAGGVASSSDMKKLSVARARLIVETTDMLEHELALRLLGRLVRGIGARLAYHEISKARPVYSRDLPQRKNNVLDIIVNNLSEHYGAMTATISDPNTTPPPGAPAFITEWLRTLLLKEWDGSAELSRCSSAGAAVRILSTLYKERDRLGLIPEDFQTPFLSDRLEPLDMPVEWIESGPSNKTLHLLSYPFLFPPSALVIYFRALNYAAMSKYYEAAMTTTRHVTQTAFGPIRVQDDVGLLAQLKTSMSTYLVLVVRRDSLLTDALNQLWRRERRELMRPLKVQMGMDEGEEGLDHGGVQQEFFRVVMGEALDSSFGMFTTDARTRMSWFQPCSLEPLYKFELLGLLMSLAVYNGLTLPVNFPTAFYRKLLGLKVKHLEHIRDGWPELTKGLGDLLTWEDGDVGDIFMRTYEFSFEAFGLVETVDMQKVDRDAPWPATSTPGRGLSGSRSLGFSPPWSEVRHYTDHVNLSPPSSMAAETAGSYGDTTKATDTLVPVQSPTPPGDEACLVTNNNRSEFVKDYVFWLTDKSIRPQFEAFAQGFYTCIDRTALSIFTPEALKTVVEGIQTIDIRELERHTRYEGGFGPSHQVIRDFWSIVRHYPAEKKAQLLEFVTASDRVPVNGIASIMFVIQKNGVGDARLPTSLTCFGRLLLPEYSSRSVMEEKLSKALENARGFGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9Z5</accession>
    <name>A0A317V9Z5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_609339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9Z5"/>
    <dbReference type="STRING" id="1450535.A0A317V9Z5"/>
    <dbReference type="OrthoDB" id="4330770at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="83" mass="9324" checksum="1905B1188B3A2A00" modified="2018-10-10" version="1">MSANWRVVFVKRRRRDPGSAPVPHPDAPSNRPALPGLSVGVLLHKSSQGRADAQRLVATRLLDRLHDPLGHFSRLQRIHPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VA28</accession>
    <name>A0A317VA28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">2-hydroxyacyl-CoA lyase</fullName>
            <ecNumber evidence="24">4.1.2.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">Peroxin-5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Peroxisomal targeting signal receptor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">BO94DRAFT_560412</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32 33">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="25">Catalyzes a carbon-carbon cleavage reaction; cleaves a 2-hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 2-hydroxy-3-methyl fatty acyl-CoA = a 2-methyl-branched fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:25375"/>
            <dbReference type="ChEBI" id="CHEBI:49188"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:58783"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:25376"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:67444"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:57376"/>
            <dbReference type="ChEBI" id="CHEBI:170012"/>
            <dbReference type="EC" id="4.1.2.63"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:67445"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.63" evidence="24"/>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462831.1">
        <property type="nucleotide sequence ID" value="XM_025614152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VA28"/>
    <dbReference type="STRING" id="1450535.A0A317VA28"/>
    <dbReference type="GeneID" id="37116295"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106359">
        <property type="term" value="F:2-hydroxyacyl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02004">
        <property type="entry name" value="TPP_BZL_OCoD_HPCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000006">
        <property type="entry name" value="2-hydroxyacyl-CoA lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000071">
        <property type="entry name" value="2-hydroxyphytanoyl-CoA lyase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000218">
        <property type="entry name" value="Peroxisomal targeting signal receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000054">
        <property type="entry name" value="Putative 2-hydroxyphytanoyl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710:SF2">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="20" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="18" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="17" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="13 27" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="15" id="KW-0832">Ubl conjugation</keyword>
    <feature type="repeat" description="TPR" evidence="27">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="27">
        <location>
            <begin position="481"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="27">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="31">
        <location>
            <begin position="644"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="29">
        <location>
            <begin position="837"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="30">
        <location>
            <begin position="1043"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="28">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="28">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="28">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00044451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00044454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00044518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00059692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00070390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="PWY71076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1237" mass="134086" checksum="9DE7B19337C3711F" modified="2018-10-10" version="1">MSFLGGAECSTAGNPLTQFTKHVQDDKSLQRDRLVGRGPGGMQEGMRSRGMMGGQDQMMDEFAQQPGQIPGAPPQPFAMEHLRRELDQFQTTPPRTGSPGWAAEFDAGEHARMEAAFAGPQGPMMNNTSGFTPAEFARFQQQSRAGMPQTANPATSSQSPMMAGYQRPMGMGGYMGMGGMGGMGIMPQTFNPMAMQQPAEATTQDKGKGRMVELDDENWEAQFAEMETADTEKVDEEANAAVEAELNDLDRSVPLTSTAEDQDYGAFESVWERVQAETATNRKLAEEGENLFDVHENFHAGDMGDWEGFDTLNTRFRNPQLGDYMFEEENVFRNVSNPFEEGVKIMREGGNLSLAALAFEAAVQKDPQHVQAWTMLGSAQAQNEKELPAIRALEQALKIDANSLDALMGLAVSYTNEGYDSTAYRTLERWLSVKYPQIINPKDVSSDADLGFTDRQLLHDRVTDLFIQAAQLSPSGEQMDPDVQVGLGVLFYCAEEYDKAVDCFSAALASTESGTSNQQEQLHLLWNRLGATLANSGRSEEAIEAYEQALNINANFVRARYNLGVSCINIGCYPEAAQHLLGALSMHRVVEEEGRERAREIIGGDGGIDNEQIDRMIHVSQNQSTNLYDTLRRSCDRLAMTSITGAQIIARTLRDLGVTVIFGIVGIPVVEIAEEAINLGIRFVAFRNEQACGYAASVYGYMTGRPGVCLVVGGPGVLHALAGIGNASANNFPLLVLAGSAETTGITKGAFQELDAISLLTPHTKLAVRASSLDFIPSAVKNAYRTCWYGRPGPTFVDLPADIIQGKCSPDYRLPQPETLRVPSPPKASGDPALILKAAQLLRTARSPLLVIGKGAAYARAEHGINQLVEQTSIPFLPTPMGKGVVRDSHPLNASSARSAALKNADVVLVLGARLNWILHYGEAPKWSPTAKIIQVDICAEEIGRNAGTAELGIMGDISLVVDQLLSSLSNWKYSPQSSAKDDFASILTASAKKNEEKALRVALRPTPPNSPLTYQRAYHIIKGTLAGLTPMDEGNIVYVSEGANTMDISRSMFPLNHPRQRLDAGTYATMGVGLGYIVAAHEAFNAIPGSPPKKIVALEGDSAFGFSAMEIETLARYRIPALIYVINNSGIYHGDSTSEDAWKTLQHETALNDTKSADGKKGLRSTSLLYETRYEMLATMCGGKGFFVRTEDELRAATVEGFKSGTVTVVNVIVEPGIGRKIGFAWQGNTAEQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VAB7</accession>
    <name>A0A317VAB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_590217</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462590.1">
        <property type="nucleotide sequence ID" value="XM_025616005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VAB7"/>
    <dbReference type="STRING" id="1450535.A0A317VAB7"/>
    <dbReference type="GeneID" id="37118148"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="181"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY70299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="331" mass="36315" checksum="2F3333693621C64E" modified="2018-10-10" version="1">MQIALFGPTGQVGQSILHALLSTTPYQILQITSPRSNTSALSTAQTLPLEQQSRLNTKSIDLVTCTTDALIPLLTDIEIIISALNGPALHSQSKIQDAGAITGVRRFYPSEYGMHHVYQPAEQGDGKGCGWGYIHPTWMEKITATEKCLHHPAITSGSMTYTIIGSGDLYNQAKEETWCPWTNPTLPSYTIYIIGDPSAKINFTHTDDLAAFLIQTIQHPEVSENKELNFVSDTVSYNDIAALLEKYSGREVQKVVYPGSLVDEVLRDRGMVPREVKAEGGAFGDDFWVLVRGVQGLGRFVRPRGMVHNGLFPVVEGVRTVEGYFGGLFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBP4</accession>
    <name>A0A317VBP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_608365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463010.1">
        <property type="nucleotide sequence ID" value="XM_025616555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBP4"/>
    <dbReference type="STRING" id="1450535.A0A317VBP4"/>
    <dbReference type="GeneID" id="37118698"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF19">
        <property type="entry name" value="DUAL O-METHYLTRANSFERASE_FAD-DEPENDENT MONOOXYGENASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="196"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY71774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="454" mass="49783" checksum="143D554C4669124C" modified="2018-10-10" version="1">MTTFPLEELSWTITKNASIVSQYLAAHQLPQPSVHGDGPSTVVPSKAPPAIQQARQHLMAASLELLQLAIGPSEYLPNLAMGFQYTATLHYLLQFNIFHLVPLPPAAAISYTDLSTMSGIPEPRLKSILRMAMTNSLFLELPDTQHVTHSATSAFLSRNPDAHTYASYMCAKSAPMALDMAAAHQKWGAGTTSLSETAYNVAFDTDMPFFEHIGQDEARMNQFARYMRNVRSSEGVDINHLVNGYPWGRIPDQAVVVDVGGSTGTSSLALAESYPHLHFIVQDLPANTETGKQMAQTLTSELSARLTFQAHDFTKPQPVRGADVYLLRMILHDWPDREAARILGNIASAMEDKKSTSRLVIMDTVLPTPGSAPVSVERIVRARDLTMMQAFNSKERELDDWRDLLTAADARFRIVGVEQPVGSAMSVLEVALSCYSEQGEDLQPAVAVVGIEQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDM0</accession>
    <name>A0A317VDM0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_264666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462863.1">
        <property type="nucleotide sequence ID" value="XM_025606514.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VDM0"/>
    <dbReference type="GeneID" id="37108657"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="832"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="605"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1122"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1165"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1551"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="120"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1165"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1554"/>
            <end position="1564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY71108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1611" mass="180834" checksum="FEEFA7FE0ADCB029" modified="2018-10-10" version="1">MNSSGNDNWHPGGPPAHPGMDQMNQQPRPLGSFSQNPPPQQGPSTQPTGPVLPPPAGPYHPANQPGGHSLPGLAELSQSHAGPHQPSAYGQHPAAPGHNAGHSLPGIGQAMQHPSPQSINRERERDSRERELIERQRQEEMVHREREQREREQIERQQLERQREQQHHPVQSHTGSIPIHQPVASKVPNSIHGPNGLLSNLGSNPANGPQGSMPTPGGPGGIYGPQMQHGESTPRSYIQHPAGPPGQAMMGFNGSGPQIPGNVAALAQGQQPILNDALSYLDQVKVRFVDQPDVYNRFLDIMKDFKSQAIDTPGVIQRVSTLFNGHPALIQGFNTFLPPGYRIECGTEDNPDAIRVTTPSGTNTLSMPRARHSLDSSGELGPSGGMGPHGRPEYFDQARPGWQQPQPQPQPQQQQGNLPGSYSPGSRMMGPSMFGQQAGQNQTQDHHFDYPTQQEQQAAAGAAAMAHQQDQRGVSQLQGAASAASAGLTRPSLLQVSAASGQGPSLTQPMNSLAGVGTGMLQGSQDLTKRGPVEFNHAISYVNKIKNRFASAPEIYKQFLEILQTYQRESKPIGDVYAQVTQLFNTAPDLLEDFKQFLPESAAHAKQQAAARQAEEAAPMSNVRGEPSYPSANALPSQTPNRDVKMPPLGQFNVKDSAKDGKKRRGGPGAPSSLGPSMSGPSATDAARMGDVQVRSSALQTGNANKRAKVHHTKPSQAEVPTVSPTLVPALPEPIQPTFSLTPTQEEFAFFDRVKKYIGNKQTFSEFLKLCNLYSTDLIDRHVLVKRAASYIGSNPELMAWFKRFMHVDEPEDKIIDVKAKQQESGLVNLSHCRSLGPSYRLLPKRERQKPCSGRDQLCYSVLNDEWASHPTWASEDSGFVAHRKNQFEDALHRIEEDRHDYDHHIEACTRTIQLIEPIVQQFLVMSEGECVAFKLPPGLGGQSEAIYQRVIKKIYDRTRGEKIIKEMFERPTHVLPIVLFRLKQKCEEWKASQREWDKIWREQMQKAYWRSLDHQAIASKAIDKKLFVAKHIQTEIQNKFEESRNLRKSGYQTAKHQFEFTFDDPAVIIDATHLLLTFIDRNSAGFGADPQKVMTFIKDFIPVFFGMDRDTFHVYMNELSRGTSPMDEGDDESLVAEESSTPRSRKGINGKKIDLLRDVLERRSEKVRRGDKEGSTPASRDGTPDAVLIPSTPIPDPTEPFDVAELKWMEHPGQGNFNQHREYNLNETYEKKAHHLYANLNIYCFFRTFEILYSRLLRIKLHEKDAHDDVRRAMVTKPAQELNLIDKFPTDFFYDCDSKANLYQQIVRMCEEVIKGDMEPSHLEETLRRYYLRSGYQLYNLEKMFAGISKFAGAIFNGDSKDRSSDIINQFFKERDKEETTHNQEIQYRKQVERLVKDGDIYRITYSPGTKKTAVQLLTPEDATLENEELSQEARWSYYVSAYTMRDPTEGVPFSQMRMPFLKRNLPAKLEQEEEYNRYYRPLVHQDGLIIRICANSYHILYEPSSYDWWWRPTAPAEDAAEDAAKEEAAVKERRRDRFTEKFVNNPHWAHGLSKDQVDESNQRFRSWIKGPEGDSGTAAAENSGTDSKGDKEDSEMADVEAPAAESKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VEX1</accession>
    <name>A0A317VEX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CCAAT-binding factor complex subunit HapE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_526016</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462900.1">
        <property type="nucleotide sequence ID" value="XM_025610339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VEX1"/>
    <dbReference type="STRING" id="1450535.A0A317VEX1"/>
    <dbReference type="GeneID" id="37112482"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000017">
        <property type="entry name" value="Ccaat-binding factor complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="78"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY71502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="265" mass="29087" checksum="5B06932B5E977797" modified="2018-10-10" version="1">MEQAAQNAGQQQGRQQPVYDTRNGGHYGASAALSAQGYAPVAELYTGTWANVNQGLQGTARDILTTYWQHIINHLESDNHDYKIHQLPLARIKKVMKADPEVKMISAEAPILFAKGCDIFITELTMRAWIHAEDNKRRTLQRSDIAAALSKSDMFDFLIDIVPREEATSHAKRSNQTAGTSAGVAGPAGATGQLPPSQHGVQHHMPPPDYSSLGQHGLQDQEYRQPTMYAGAVQSDPTAAYGQHQPQMFEGMYAAYPHLPPQQVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFH1</accession>
    <name>A0A317VFH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_539011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463398.1">
        <property type="nucleotide sequence ID" value="XM_025612609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFH1"/>
    <dbReference type="GeneID" id="37114752"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37063" checksum="1F47C6891E0CE62C" modified="2018-10-10" version="1">MADVLSTLRETLPSLLSWKALALVLAILSFKNLPGVWHIRLGYHLFINLRRHPTDAPFPTCPPSTNSSSSTKSIKSHPIFAPHSLTTHTSLWETDYNIHKSNSTYFSDLDISRTAIVTRVYTPGVTLISKQLDTELAKVSKEQGRENVGKKIYIALGSTYTSFKREIKPFEGYKVVSRVVGWDRKWVYILSLFVSGKGGKGKVFATAVSKYVVKKGWLTVHPERVLRASGLYPDVPIAEGITNKDKDGEGEGEEGVVLVEEGEGLETPEGIKENVAVDGGVVGEVLDKVKHGKAWDRNEWTWEQIEEERLRGLKVVEGYVGLDEKLLAEWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHN9</accession>
    <name>A0A317VHN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_247453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463312.1">
        <property type="nucleotide sequence ID" value="XM_025606421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHN9"/>
    <dbReference type="GeneID" id="37108564"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16732" checksum="28F1FE54240B3552" modified="2018-10-10" version="1">MSQNGVYERRRSTSPDGQIKSMCESKFWYMNVPDGQPSINLPSVGPVAGEGNHQKEPHVRYMQSERKKKGGGGCKNKDEAKCRKDEKVKMGITPGKGRDQNPLPILDSITPRPISVIRSARLHSRTFRYSKRDEKKLERKCGDKKGGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VI73</accession>
    <name>A0A317VI73_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_259429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462938.1">
        <property type="nucleotide sequence ID" value="XM_025606476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VI73"/>
    <dbReference type="STRING" id="1450535.A0A317VI73"/>
    <dbReference type="GeneID" id="37108619"/>
    <dbReference type="OrthoDB" id="4153178at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY71540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="76711" checksum="EFA1E3BBAD93B999" modified="2018-10-10" version="1">MRSAVPTTNSPKRRALHERSPSHTNENSPPASLRAVSDRYNDQEEPDVYSATPYPTKPEQILLPRPGKGQDFIPDARFHVDEAPDHYLGNTSTDISHIADSSLIDQSLSDPWDLSSTFDAANTPSQVWEDDPSSSKSSFPDPEPHDHKPTDQKSDEGSVAAYSDEEPNTLPRAAPTIKTIVSQTPSRNPSGPETVASSNSSPNVVPIGPPSSPNFVALDSSSLNFVPLGASSNPGSVTRSNSLSSLNSLGTVIRYIGAAQWTHGSSSEQSSSRSRSQSVRSNPPYQAPSLRSNSIQARERSHSRSVTSSSRSGPPSDIQAIVDSGVFIQYPTIQAPSSSSSRVDVSTSEDAPDHNPQEPTGDYSSERFKSHLSTVPSMWSAECDSRSISPAADSFDNSQGEPKRPSAALVRQRPTSSSMWLVNDSDGDEHMDNISSLPARPSNPAVPCSVSSESRRSSMRSNMRPPTSGSFSFHILPNWAKMYYRSDEQTADSVLSVGEASRPPSARASTSHTNALHRLPTAASRARTFTSEMREVRWKPDPRDPRSHWVREPEPQSREASRHRLRHSWSPHLFPDRRAVNPRKGTWGAPSLDSRTEPLLGRRNIQVWSFCVGFVFPLAWLIASFLPLPKKPDTIPEADVESQLEMTLRMRLFDLERRRYENARWWRKLNRWMNPLGLVIITIVVTLAVVGTTVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJP3</accession>
    <name>A0A317VJP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_229672</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463746.1">
        <property type="nucleotide sequence ID" value="XM_025606292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJP3"/>
    <dbReference type="GeneID" id="37108435"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY74553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="153" mass="17593" checksum="CA60B65F861A26CF" modified="2018-10-10" version="1">MGHIKHHPADRFLLLSPQTRYPHLNAQDYFDFLLAVTLPTDQLLAPVPSSLGRNFLMEERNRALDRRNQGRKSWPVFTRGSSLRKRETGPETLSHVIQPLQRLSRFPLSPSSFLLCFSIFALLVMDIKRQFPGVHWVWGGASPLSMRSILSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKM4</accession>
    <name>A0A317VKM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATPase inhibitor, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_524669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inhibits the enzyme activity of ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ATPase inhibitor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463523.1">
        <property type="nucleotide sequence ID" value="XM_025610281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKM4"/>
    <dbReference type="STRING" id="1450535.A0A317VKM4"/>
    <dbReference type="GeneID" id="37112424"/>
    <dbReference type="OrthoDB" id="5532350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.500">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007648">
        <property type="entry name" value="ATPase_inhibitor_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04568">
        <property type="entry name" value="IATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY73771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="101" mass="11209" checksum="56B2E02C47D32651" modified="2018-10-10" version="1">MLRQSITKPITTTNRLLVSRSFSALAPRMGAGDTGAPRAGGAAHSDSFTKREAAQEGKYIHDKEIEKLRALRAKVQEQRKHLDELDKHIDDITKNQGGEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VL24</accession>
    <name>A0A317VL24_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_236201</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463579.1">
        <property type="nucleotide sequence ID" value="XM_025606329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VL24"/>
    <dbReference type="STRING" id="1450535.A0A317VL24"/>
    <dbReference type="GeneID" id="37108472"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY73827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="110" mass="12779" checksum="F78104EAC14F2202" modified="2018-10-10" version="1">MGLVYNVYLTASKIFGCKKCKTHLADYDDIISRNFRGQHGKAYLFNNVVNITQSEAVERSMTTGRHIVRDIHCRQCKETVGWKYDKAYETSEKYKEGKFILEEELLCVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLH1</accession>
    <name>A0A317VLH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_538830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463540.1">
        <property type="nucleotide sequence ID" value="XM_025612571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLH1"/>
    <dbReference type="STRING" id="1450535.A0A317VLH1"/>
    <dbReference type="GeneID" id="37114714"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01370">
        <property type="entry name" value="KISc_KIP3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000053">
        <property type="entry name" value="Kinesin family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="633"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="693"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="760"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="930"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="693"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="808"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY73788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="953" mass="105278" checksum="BD0271054EF5B14A" modified="2018-10-10" version="1">MPVCLNPFHAACLLARFNWSCNRVFDPPEDNPVQKFSKSVVPQGKRVKDQTFAFDRIFDQNASQGEVYESTTRNLLDSVLDGYNATVFAYGATGCGKTHTITGTAQQPGIIFLTMQELFERIDERSGEKATEVSLSYLEIYNETIRDLLVPGGSKGGLMLREDSNKSVSVSGLSSHHPQNVQQVMDMIMRGNECRTMSPTEANATSSRSHAVLQINIAQKDRNADVNEPHTMATLSIIDLAGSERASATKNRGERLFEGANINKSLLALGSCINALCDPRKRNHVPYRNSKLTRLLKFALGGNCKTVMIVCVSPSSQHFDETQNTLRYANRAKNIQTKVTRNVFNVNRHVKDFLVKIDEQMALINELKAQQKDYEKVAFAKFKKQTEKKDAVIREGLSRIRNAYDHSQSERQERTNHMIKQKQISRRIGLLSSWIAAFDHVCASCEIDDALSNLQAVRKTAQGILLELESSRQHYHQRLARSTWDRGMNSAVEHAVRQLQDFDISDNNDFVNMSREAELLRATADREALAAVAEQDKAGEAATVQLLLQAQFELMTELENLMQLSEEDAIDQGKKMLAKMLNSCSSTASSIVKPDGSLPPMPLSPIKASPVKQKKRLSIATAVPTSRTMLAPILTPTAAPPSPTKGSPRRRKLNVGRKSVSFSPKKTQPKPTKRGVRWKDDEHEGTLTEFQKTPQKTQITTIPENSPEPQLPRTSPIPRGIPVPTRNFSPSSGSPPISAIPELTLNIQKNSRFKAGFLTKKNSSSPIAPPPTTTLPLSDHGKSPLRDIEGSSFLNRTPAERPSRIAVRTSSGSYSGSPAAESKTSWKASKDDAIKITSAMRRISGGSFGVGSSANTLRIHRRRSPTSATYGSSPTENNTMNTMFTASQARRMVKSEKELEGKPGVLGPRTLPIMKNTHRRTTFGGDIRPRRLSVMAGPSPPESFYPSAGFALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLN0</accession>
    <name>A0A317VLN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA damage checkpoint protein Rad24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_233363</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463524.1">
        <property type="nucleotide sequence ID" value="XM_025606311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLN0"/>
    <dbReference type="STRING" id="1450535.A0A317VLN0"/>
    <dbReference type="GeneID" id="37108454"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="233"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY73772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="260" mass="28986" checksum="3ECBAB489286907E" modified="2018-10-10" version="1">MGHEDAVYLAKLAEQAERYEEMVENMKVVASADVELTVEERNLLSVAYKNVIGARRASWRIVTSIEQKEESKGNESQVSLIKEYRQKIEAELAKICDDILEVLDKHLIPSAQSGESKVFYHKMKGDYHRYLAEFAVGDRRKGAADASLEAYKSATEVAQTDLAPTHPIRLGLALNFSVFYYEILNSPDQACHLAKLAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSSEAEPAAEPSAPADKKDEAPAEGEKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VML5</accession>
    <name>A0A317VML5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_549956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463425.1">
        <property type="nucleotide sequence ID" value="XM_025613470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VML5"/>
    <dbReference type="STRING" id="1450535.A0A317VML5"/>
    <dbReference type="GeneID" id="37115613"/>
    <dbReference type="OrthoDB" id="5409998at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="331" mass="34808" checksum="49D742FF622B8D48" modified="2018-10-10" version="1">MAATNFSNPKSLDVLTSMVNQTLVETGRFFKTGGSLQSRAQLKRSIPIAHDQFQNALDNLSEQIFLAKAFLERDYEAVKARKAALQPAEDVVMSDSEVKIEPESAPQPPEQPVVATDMVQAKVEPADDVLASKPEANVNDNKQISGDQPVKVEKSDESVAGVAGAQSLSAPGDFNFDSMLNDNAGTNDFDLNLDFGDDDVGNDSFLSGSNILNASTGPNNGSNGANNQPTDATPALPGSESNPATAPMGGDAFDLELQKAAAFTSQGDTSGEQPFDGQGGGNVEDVMPGESSFDDLFMESDNFGGDDPGDASLLDGDGLVNINELDDSWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRB7</accession>
    <name>A0A317VRB7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_206657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464318.1">
        <property type="nucleotide sequence ID" value="XM_025606123.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VRB7"/>
    <dbReference type="GeneID" id="37108266"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="1"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="866"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2219"/>
            <end position="2297"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="866"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1015"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="898"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY76505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2303" mass="251415" checksum="E78F480E4D760718" modified="2018-10-10" version="1">MHMRGGYFLQDEDIRSFENEFFGINNLEAKYMDPQQRKLLEVVFECFESAGLPLEKLSGANVGCYVGNFTVDFQLMQLRDAEYLHRYTATGMGTSILSNRISHAFNLKGPSLVIDTACSSSLYCLHIACVALQAGECEGAIVAGANLIQTPEQHLATMKAGVLSPTSTCHTFSDTADGYGRADGVGALYLKRLGDARRDGDPIRSIIRASAINANGKTAGITLPSSLGQAEVIRKAYTKAGLSLDETTYIECHGTGTAVGDPIEVEAVSIAFRRPEGSAPILIGSVKSNLGHSEAASGISSVIKGTLALEHAFIPPTIGVQRLSPKIKSSKWNVQVVTKGREWPGAESTNVRRMGVNSFGYGGANSHIILEGASSLLQGLPFPKQQARPSQKRTTFLFPLSASTPAALAARCQDLASYDLSSKSLADLAYTLGERRSQLRTRGFVVASQATLQKKLTEGDLVTLSGVAPEPPSQYAFVFTGQGAQWPQMGADLLLEFPVFCAALADQDAVLQSLPNPPSWTLSDSILEPPETSQIHDASRSQPVCIAVQVGLVDLLWSWNIRPATVLGHSSGEIAAAYAAGHLSRAQAILVAYYRGLAIKSLPTVGSMAAVGLSSDAASVEIARAQLQGQIVVACINSPESVTLSGDEPAVDAIVATLQARNIFARKLKTGGRAYHSHHMLAIGGEYETLMGVAFSDHRIPSFQYARGASFFSSITGQLKVDGFTAAYWRENLEKPVRFVDAVSRVAQSGRHQMIELGPHSALELPIKQIRAQLQLSADQLPYISALIRGQNSTESVLSLAGQLWLNNHPIQMSLVNHPVYYKGNAGGLRPQVLHDLPPYRWTYDTLLWNECRQSSEFRHRQHRRHEILGSKVPAGNATELVWRNLLHSDDVPWLLDHSLEKTAVFPGAGYLAMAAEALGQALGQAHFAGHTIQFQNVHFLSALAVPSSQAPPVELFTSLRQTPHTKTVSSSIWWDFSISTYEEGTATVRATGSVSRLDSQEALRPVCDINPAVLRPSTAGAWYERFVGEGLNYGKAFTSIMDVSVPCSPTERACRAQVRFTQQSPGNEGYEAEYPFHPILLDAMVQAGIIATSAGCTHEMKAFVPTAIRWATFRVPGPVSPETKCSINATASPVGFGAAGFQADLVTSENQVMAQIEWGRLRQYEPNRTKAPIARHPMLRVLWKPKIYGLEFMRDLDFARYLDSFVGETGSSTMADEGLLKLMATIHLLSHRNPRLRILELGSDDYGFTLAALALLSADNDYRHLAFYSTGYLDEERHLHAADWDLKAHKPTETESFPVVTDGQKQWDLIVLPATPSATRYMRDHLHRLTKFLSSDGVVLAKPIVGTWLGEDSSSDYNALRSRLTNGGEEILLARSPTASSLPEVAKNKPLVVIEKDPSALGDSLVAIKGATRLAFDRIAADSETLLRGATVISLIEVSHPLLATISDNEMGAIKVITDNASTLVWVTNGDIMSGTRPDFALASGLSRALMLEQPSLRFLTYDIDDPTRDPSRSTHNLMQTLLEINEPLADFEYVEKNGVVHISRFIPDDDLNREFRQRQGSEMVELSLQEARPVQLALDQPGQLDGIYFKQIGLPRTLAPDEVQVQVKAVGLNAKDVYVLAGKVDSRDATCTLEYSGVVERVGDEVEGLRVGDRVVAMAPGHFRSSEIVPQWACQKLREDEDDATMCTLPLVYSTAIYALMMRARLQPGESVLIHSGAGGVGIAAIQIAQVIGALIYTTVSTEAKKQFLVTNFGIDPGHIFTSRDDSFARNILAATDGKGVDVVLNSLTGDLLHASWRCCAAFGRFIEIGKHDLADDGRLEMNRFLHNATFSAFDLADLYYHPRESYRELWSGLLSQVIDLYRSRRIAKVEPIRVFSVSEISNSLRYFSSRNRIGKVVVSLESESTTIPVQILKYRTTFSPSKTYLMVGCLGGLGRSMAKWMMSRGARKFVFLGRSGMDKPSARQLIEDLALHGAQCKVIRGDVCNRADVEAAVAAVDGLIGGVIQAAMGLSEAIFTAMSNKQWHTGIDPKVRGSWNLHHAIKGKDQALEFFLMTSSVSGSVGTATESNYCSGNYFLDTFARYRREQGLPAQAIGLGMITGVGYLHDNPDIQALLVRKGIQAITEDELLQMLDITLSNNHLTIPHPVDHGANAHVLTGLEPFGLMALRQKGFQVTNLTFRDPRAAILSRVMDDDDAAAASKPKDASAPHPELEENLPLPEAIQRSLARRLGNLVLLPLEKVHVNKPLAQFGMDSMIASEFRTWLFRVFDVDVSFLELLSKTVTVASLAKTVMEKVERRPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRQ7</accession>
    <name>A0A317VRQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_538409</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY75981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463978.1">
        <property type="nucleotide sequence ID" value="XM_025612482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRQ7"/>
    <dbReference type="STRING" id="1450535.A0A317VRQ7"/>
    <dbReference type="GeneID" id="37114625"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016256845" evidence="3">
        <location>
            <begin position="20"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="47"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY75981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="583" mass="62610" checksum="104CDDB70657DA9A" modified="2018-10-10" version="1">MIFSRSSLLLGTLCALGLASPLRSSNTAPTVHLPDSDVWFTGTTVNSTESFLNIRFGEDTSGNNRFAPPKPYAYPSGSVVNATQSGAACPQQKQPLPDFPLFDNVTKISEDCLTLRVDRPAHTSASDKLPVLVFIFGGGDTIGQIYDSAYDPKLLVAGAAQKDVPVIYVAMNYRVGVFGFASSPALNESDSLNAGLLDQRLALWWIQDHIAAFGGDPDQVTIFGESDGATGVGLQMTAYGGQVAKVPFRRAIMESGAASGDSGTAFDESGQHTAVLIDRINCTASTSQEELECLRRLPMLTLLNTAYAYELTLNSMGGMDVFKPVSPSSFIPDRPTQLLKSGRFARDIDLISGWCENDGAFFTSTDLKTSADVAENLRESYPRLSNASIAKALQLYPLSDFSNDTTVDPPVSAQYFRASQMERDHGFTCPSLLAVETNAQYASHGHVRNYLYSLNQTAFAEVFALEGLTYYGVPHFSDIPYIFNTVTDGLLAPVSTASDRQLASAIGASWASFATFGDPSHANGTVSGWSQAWSSSNSTSAAPKLRVLGGPDSRFTGGRGYHEKLVQRCAFWNSDEVTAAFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VST5</accession>
    <name>A0A317VST5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_538231</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464184.1">
        <property type="nucleotide sequence ID" value="XM_025612446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VST5"/>
    <dbReference type="STRING" id="1450535.A0A317VST5"/>
    <dbReference type="GeneID" id="37114589"/>
    <dbReference type="OrthoDB" id="413400at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052606">
        <property type="entry name" value="DnaJ_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44653:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016403502" evidence="8">
        <location>
            <begin position="21"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="44"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="353"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY76371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="401" mass="44642" checksum="5AD7B72A00F1D5E9" modified="2018-10-10" version="1">MRPIALRLLVLAALIVLAAAWSKEDYEIFRLNDEVTAAEGANVTFYDFLGVKPSANQDELSKAYRQKSRLLHPDKVKRTFIANSSKDKSRSKSSQASVHVNKGRSQREIAAAVKEAHERSARLNTVANILRGPARERYDHFLKNGFPKWKGTGYYYSRFRPGLGSVLAGLFLVFGGGAHYAALVLSWKRQREFVDRYIRQARRAAWGDESGVRGIPGLDSAPDPASAPSPAPEPEAAAMPMNRRQKRMMDRENRKEGKKGGRATSRNSGTVTPTFESVEPTGERKRVIAENGKVLIVDSVGNVFLEEEMEGERQEFLLDIEEIQRPTIRDTMVFRLPGWFYHKTIGKFLGPSHTADSGAEAEEELSDMVEQSAEGISSSAVPSKTGSSKRRGKRSQRSSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYF2</accession>
    <name>A0A317VYF2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_537819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464554.1">
        <property type="nucleotide sequence ID" value="XM_025612358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYF2"/>
    <dbReference type="STRING" id="1450535.A0A317VYF2"/>
    <dbReference type="GeneID" id="37114501"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY78042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="471" mass="52714" checksum="64FB87FFF2BDABCE" modified="2018-10-10" version="1">MVADTSYYDALGVPPTATELEIKKAYRKLAIVTHPDKNPGDETAHARFQEIGEAYQVLSDEELRKRYDKFGKEDAVPGGGFEDPSEFFGMIFGGNAFVDLIGEISLMKDLTTTMDITMQEMEEDELAASAEEKLNIHEEETQAHAAEGAAEATSAESTTAAPEKPAAAPSPSSGTSTPRRYMGQQAIMDKSEEEARMEAAGLSQEEKELRKKEKKKGGLSREQQERLAAYELERKKARDDRVNTLATKLVDKISVWTETDKSADMTRAFEEKIRLEVENLKMESFGLEILHAIGATYVQKATSFLKSQKFLGISGFFSRLKDKGTLAKETWTTISTAIDAQMTMEEMAKLEERGGEDWTDEKKAEYEKKVTGKILAAAWRGSKFEIQSVLRDVCDQVLGDKRIKLDKRVERAHALVIAGNIYSKAERDPEEEGDFMAFEQLMAESMTKKGKEDKKKKKKHDHHHEDVPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2C3</accession>
    <name>A0A317W2C3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_577102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464994.1">
        <property type="nucleotide sequence ID" value="XM_025615163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2C3"/>
    <dbReference type="STRING" id="1450535.A0A317W2C3"/>
    <dbReference type="GeneID" id="37117306"/>
    <dbReference type="OrthoDB" id="437889at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07652">
        <property type="entry name" value="F-BAR_Rgd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000063">
        <property type="entry name" value="Rho GTPase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000041">
        <property type="entry name" value="Rho GTPase activator (Rgd1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF136">
        <property type="entry name" value="RHO GTPASE ACTIVATOR (RGD1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="37"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="478"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY79422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="673" mass="73986" checksum="B84E9A42322415EE" modified="2018-10-10" version="1">MADAALHDSPVPDPDARPSSDGSAGHPGALELRPGPPPMTEELKARLDKVIYSDIGVTTLLTRLKQSVSSAKDFSTFLKKRSSLEEEHAQGLRKLSRSLHDSAYRNENRQGTYGQNYNELNRFHDRMADHGLQFSVSLQQMADDLQELASNIERGRKQWKQTGLSAEKRVLEAETSAEKAKAKYESLAEQYDRVKTGDKQGGKFGLKGHKSAAQHEEELLRKVQNADADYAAKVQAAQSARQELIATHRPQAVQNIQKLISECDSGLTLQLQKFATFNEKLLLGQGLSISPLKDATANPNLAPKSLYEVVSQVDNEKDFREYVLSHERNPGAVTSDQIRYQRHPTLGGSGPVVPASQPATQNKRQSIFLPQSFSQQNLPASTPVSSQPPAPAPAPVSATAPAPALAPAPTTEPLPYPQNPDSYSTPHFQPPYPTSSAPSEHRHINQAPVPPAKTPLVPAGNGFQSSPNLPPLKPVFGVSLDDLYTRDGTAVPMIVYQCFQAIELFGLDMEGIYRLSGSATHISHMKALFDNDSSQVDFTNPENFYHDVNSVAGLLKQFFRDLPDPLFTSHTYTEFISAARLDDDIQRRDSLHALVNNLPDAHYATLRALILHLNKIQEHYTQNRMNAGNIAICFGTRPTLMGANSGGNIADAGWQVRVIETILVNTFQIFDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2X8</accession>
    <name>A0A317W2X8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_567532</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465128.1">
        <property type="nucleotide sequence ID" value="XM_025614634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2X8"/>
    <dbReference type="STRING" id="1450535.A0A317W2X8"/>
    <dbReference type="GeneID" id="37116777"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000073">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="238"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="306"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="399"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="440"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="552"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY80269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="610" mass="67822" checksum="5C5610360B80AC58" modified="2018-10-10" version="1">MATNSGYGQVIEYIQDRLYLASYDNPPDARTPFPYPVEQSRSPSKRSARAQPSTPGSKKRSPVYFTVDDTLLYNSFHADFGPLHIGHLYRFAVHFHEILGDPANSDRAVVFYSKTDARSRANAACLVACYMVLIQSWPPHLALAPIAQADPPYMPFRDAGYSQADFILNIQDVVYGVWKAKEQSLCSLRDFSLEEYEKFERVDMGDFNWITPRFLAFASPQHQPIEPVPQNTPEFDALPSTVSEVMSSKLPLSFKNVLAHFSSRNIGLVVRLNSELYSPSYFTALGITHVDMIFEDGTCPPLPLVRRFIKMAHEMITVKKKGIAVHCKAGLGRTGCLIGAYLIYRYGFTANEIIAFMRFMRPGMVVGPQQHWLHLNQGSFREWWFEDSMKEKLAQMQVAPITPGRPSTRQRANGPVATPPNNGHSKRAALGEIDHNEGAGTQAEENLPAPTPGQPRKSHRKDSRHHPYARTTSGSLVVDKEASKNGEHTSHRHHRLSNDSSESEEEIQLRMLAKRSSKSPVASPSQRSVSYSATVTASYTLNDDNRENWGDAAAYAAPKTPMGNKSGNGAIAVTKVRTSPRRVTDSRSETRGVRKASGRVGSAGSPTRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W320</accession>
    <name>A0A317W320_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_587857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465264.1">
        <property type="nucleotide sequence ID" value="XM_025615859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W320"/>
    <dbReference type="STRING" id="1450535.A0A317W320"/>
    <dbReference type="GeneID" id="37118002"/>
    <dbReference type="OrthoDB" id="7939818at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.960:FF:000002">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000001">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000004">
        <property type="entry name" value="Glutamate-cysteine ligase Gcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="516"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY80405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="668" mass="76161" checksum="0B069A04BFEA6B79" modified="2018-10-10" version="1">MGLLALGTALDWPEAKKRADQVRKWGIEQLLANWHRAKGKERNALLWGDEVEYLVVAVDDETKKARLSLAQAEILKSLAKDEALWKEGNSSKSQNQGHEGEEPPHFHPEFGRFMLEATPGKPWGIDFKDLLKVESNMKWRREVAKAHMAPNESPITLTTFPRLGTKDDYIQPYYPPSGPALRSQFVPDEIANPHIRFPTLAANIRSRRGRKIELNVPIYKDTNTPEPFKDPTVDYDLHNWPEDDDVRNGAAKDGHVYMDAMAFGMGSCCLQITFQAKNMTEGRKLYDQLSPLGPILLALTAATPIYKGFLVDTDVRWNQISGAVDDRTREELGELPLKNDRWRIPKSRYASNSTYISQDPRLRKEYLDPDLIVDEDIKKRLIDDGMDDLLATHFAHLFIRDPLVIFSEDLEELDLNKADHFENLQSTNWQHMRFKPPPPDKDDIGWRVEFRSMEIQMTDFENAAFSIFIVLVTRAILSFDLNFYIPIQRTTENMETAHARDAVLEQKFYFRKDPFARRRQNQQSPNGSNVSSNSSSAQNTPPPSPPLNPVESEYDLMTISDIINGSADGTFPGLIPLVESYLNSVNVDVETRCSLASYLDLIRKRANGTLWTGAKWIREFVASHPGYKHDSTVSEEICYDLVKAVDEMTVKEGKHGTIGWELLRGKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W558</accession>
    <name>A0A317W558_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_536924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465762.1">
        <property type="nucleotide sequence ID" value="XM_025612149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W558"/>
    <dbReference type="STRING" id="1450535.A0A317W558"/>
    <dbReference type="GeneID" id="37114292"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY81694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="302" mass="33041" checksum="16F27E58777A6395" modified="2018-10-10" version="1">MVQNVIVLGASGALGSVVLNALADSGFTVSALVRSSSKATFPPGIPVHRVDYDDLQALTAAFQGQDAVVSTITTAHVDAQRVAVDAAVAAKVQRFIPSEYGGDSSNPDRVDVGVFQSNKRRIVEYLESKEKDGLTWTAICTGSWLHWNLELDSAELGWDLPGRQVTIYDGGEPKVDLCTLEQVSRSIISTLRHLEETENEYVYVKSFSANQNELLPLVERLSGQKFKVHHCSSEERASTGMKELKEGKQESMYKVIAATAYGPWGIGQFGNKPDKWMKVLELPTDEDLEAAVRASLKRKGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W7V4</accession>
    <name>A0A317W7V4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_548023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465829.1">
        <property type="nucleotide sequence ID" value="XM_025613371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W7V4"/>
    <dbReference type="GeneID" id="37115514"/>
    <dbReference type="OrthoDB" id="10602092at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016259792" evidence="2">
        <location>
            <begin position="20"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY81761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="189" mass="19443" checksum="EEF7FC7E63B5A8B0" modified="2018-10-10" version="1">MKPTHTLAFLALCAGLSLAAPGGPGMLNTDYHNIAFANIFTGADSNQHLDVHGVHGRDGISASGDIKAHVGRREIFDSNDDLPVHGVHGRGHVSGSGDVDAHVGRRQDDGYGSSVLGHSNERRNDIGDVIGDVVHARDNISGSGKAGASLSGEDLNRRQKASAGGEEDVGVHGVRGRGHVSGSADADAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBC7</accession>
    <name>A0A317WBC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466264.1">
        <property type="nucleotide sequence ID" value="XM_025612025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBC7"/>
    <dbReference type="GeneID" id="37114168"/>
    <dbReference type="OrthoDB" id="5387413at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="288" mass="32739" checksum="E65006B203BF8015" modified="2018-10-10" version="1">MALPQGPSLSLFLIHFSHLLTSSKSRSRTTLSNTVTSTVYLSSPRDHTSVTLSPSKSSRFWPPFYYSVRESLRLERPPPRTRPPLRRSTTMPHPVEQPAEPVVLVRDLEADEQLVISQFERHASHCSQCADPMTVLEEKLLLCKRGNQYARDVVDYLRSKNGKIYSVVDLEHNRTTLVKVPLKNAAARQLLLAIEQGLCVLPKTSSVTPPPVISYDPAPPRRASTQENMACTTIIEREPRSLKRRRVIVYTSPRSSPSRGSLYEADAADRIERVNRTSRIYRPSEYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBI9</accession>
    <name>A0A317WBI9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">beta-glucosidase</fullName>
            <ecNumber evidence="11">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_519209</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466171.1">
        <property type="nucleotide sequence ID" value="XM_025610061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBI9"/>
    <dbReference type="STRING" id="1450535.A0A317WBI9"/>
    <dbReference type="GeneID" id="37112204"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016344646" description="beta-glucosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="13">
        <location>
            <begin position="775"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY83703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="870" mass="93606" checksum="01E3EA70141F87DC" modified="2018-10-10" version="1">MSMTRFLYFTLLSGFIPWSLASPEGHLHPRDDEAFSPPYYPAPKGGWLSEWTDAYEKAYKVVSNMTLAEKVNLTTGTGMFMGPCAGQTGSALRFGIPNLCLHDSPLGIRNSDHNTAFPPGVTVGATFDKDLMYQRGVELGQEARGKGVNVLLGPVVGPTFRKPRGGRNWEGFGADPSLQAIGGALTIKGMQSTGAISCLKHFIGNEQEMHRESSVITQGYSSNIDDRTLHEIYLWPFAEGVRAGTGSVMMAYNDVNRSTCSQNSLLINGILKDELGFQGFVVTDWLAQLGGVSSALAGLDMSMPGDGAIPLLGDSYWGSELSRSILNGSVPIDRLNDMVTRIVATWYQMGQDEDYPLPNFSSNTLDETGPLYPGALISPSGVVNQYVNVQGDHNITAHAIARDAITLLKNDNHTLPLSTADSLHIFGTDAGPNSNGLNSCTDQGCDNGVLTMGWGSGTSRLPYLATPQEAIANLSSNAQFHITDSFPSSLSVNSSSIALVFINADSGENYITVESNPGDRTTADLYAWHNGDDLVTAAAAKFSRVVVIIHTVGPLILESWIDLPSVKSVLIAHLPGQEAGYSLTDVLFGTYSPSGHLPYTIPYQESDYPSSVGLLDQAFGQIQDPFTETLYIDYRHFLQANITPRYPFGHGLSYTTFTYSSPVLTPINPPNTTYPATRPSKGPTPVYPTSLPSPSEVAWPSTLTRIWRYLYPYLDNPSSIPSNSSTAYPYPSGYSTTPKPAPRAGGAQGGNPALWDIAYSIQVTVTNTGNYSGRAVAQLYVGLPGSDVLGIDTPAKQLRQFEKTGTLAPGESQTLELTVTRKDLSIWDVVMQDWKAPVDGEGVTFWVGEGLGDLRVVCVVGDACGEVDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WES3</accession>
    <name>A0A317WES3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_598978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466195.1">
        <property type="nucleotide sequence ID" value="XM_025616294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WES3"/>
    <dbReference type="GeneID" id="37118437"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="104" mass="11719" checksum="BB417145F8C3A17F" modified="2018-10-10" version="1">MPVTWLQVHHTEQEMSSRDDFQDCHPLTYFCRLHSKQSDPLYGPRGMISSLISQLAHGGSLVWGFTAGWASYRDGRYLPYDTARISNAHDGRPAISTAMKGYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFB0</accession>
    <name>A0A317WFB0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_494435</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466560.1">
        <property type="nucleotide sequence ID" value="XM_025609232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFB0"/>
    <dbReference type="STRING" id="1450535.A0A317WFB0"/>
    <dbReference type="GeneID" id="37111375"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016295979" evidence="7">
        <location>
            <begin position="21"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="248"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY84635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="732" mass="81948" checksum="2692259D887559D0" modified="2018-10-10" version="1">MRVSLLAWSLLSLVSIPTLAAPSNDVSPSHHLVKRDGPSDAKSELQSTTFNGIEVPPIKALGPDNFEETVKDGYWFVKQYSPSCPHCQKIAPTWQTLYEYYYTSNPLSSSSSKSPDTDSLNSFHGFYNFHFAEMNCLAHGDLCRKLDVKYFPTFALYHNGELVEQYTGKKSMEGLSEYVEDKLEQIKPGSRPAQGLNLPKPGDKGVDTKAEPDTPVAKDKDREAGAKAGEKHNEQAAQLTVEDEPADKTSSKSKPKAKPAPANPQGISVPLTAESFQKLVTTTRDPWFIKFYAPWCHHCQALAPNWREMAKEMQGVLNVGEVNCDVESRLCKDARVSAFPTMYFFRGGERVEYTGLRGLGDLISYAKTAVDVGSGVQDVDATTFKELEEKEDVIFLYFYDHATTSEDFEALERLTLSLVGHARLVKTNSAALAERFKISTWPRLLVSRDSRPSYYNALAPKDMRDFRQILNWMRTVWLPIVPELTASNAQEIMDGKYVVLGILSRKHSDEFLQSKRELKNAALEWMDKQTQLFQLERAELRDAKQLRIEEAEDRNDQRALRAAKNMRITIREDDKKQVGFAWIDGDFWERWLRTTYGIDVENGERVIINDQDNRRYWDTSSSGASIMASRTSILETIPLVIANPPKLTPKSTVGTFESVFFFTRSFISGHPIIFFILLTLSVAGATFLARGRAARRGGRGGILGVTGNTGGGFFNLDGKEGLLNGGSTGKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WG72</accession>
    <name>A0A317WG72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor CLF1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Pre-mRNA-splicing factor clf1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_536657</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465965.1">
        <property type="nucleotide sequence ID" value="XM_025612064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WG72"/>
    <dbReference type="STRING" id="1450535.A0A317WG72"/>
    <dbReference type="GeneID" id="37114207"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000048">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000254">
        <property type="entry name" value="Cell cycle control protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000306">
        <property type="entry name" value="Cell cycle control protein cwf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="12" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="15">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="12">
        <location>
            <begin position="72"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="225"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="14">
        <location>
            <begin position="376"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY83180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="677" mass="82072" checksum="5C70B9A64B28A94C" modified="2018-10-10" version="1">MESSRGPPRVKNKAAAPVQISAEQLLREAVDRQEPALQAPTQRFADLEELHEYQGRKRKEFEDYVRRNRINMNNWMRYAAWELEQKEFRRARSIFERALDVSPTSVVLWIRYIESEMRNRNINHARNLLDRAVTILPRVDKLWYKYVYMEETLGNVPGTRQVFERWMSWEPEEGAWSAYIKLEKRYNEFERARAIFQRFTIVHPEPRNWIKWARFEEEYGTSDLVREVYGVAIETLGEDFMDEKLFIAYAKFEAKLKEYERARAIYKYALDRLPRSKSMTLHKAYTTFEKQFGDREGVEDVILSKRRVQYEEQLKENLRNYDIWFDFARLEETSGDPDRVRDIYERAIAQIPPSQEKRHWRRYIYLWIFYAIWEELEAKDIERARQIYNECLKLIPHKKFTFAKIWLMKAQFEIRQMNLQAARKTLGQAIGMCPKDKLFRGYIDLERQLFEFVRCRTLFEKQIEWNPSNSQSWIKYAELERGLDDTDRARAIYELGIDQSTLDMPELVWKSYIDFEEYEGEYDRVRQLYERLLEKTDHVKVWINYARFEINVPDEEEEEEEEEEEEERPISEDAKRRARAVFERAHKVFKDKDLKEERVELLNAWRSFEHTHGSPEDIDKIEKQMPRRVKKRRKLDDDRYEEYMDYVFPADDQSAANLSKLLQRAHQWKQQQQGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WGE6</accession>
    <name>A0A317WGE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_495556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466035.1">
        <property type="nucleotide sequence ID" value="XM_025609267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WGE6"/>
    <dbReference type="GeneID" id="37111410"/>
    <dbReference type="OrthoDB" id="5381672at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="611"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="795" mass="88086" checksum="8A62D10E45F0AE9A" modified="2018-10-10" version="1">MHRSPLHLIVVVYRMAALNTPSNPAGNGQKISQKKSPIQEPLRYRTKSLYLLAFYVAILLIPWVMTCVMMVRPLDATSYTRQGFGLPASVLLNILASLDVITVLEKIQAVLAIPIVSGFLAQAAVVYAQRRSPDQKLSLQQLIALADRPWANVISWFRCLSSNNGTGSWLAVFGGLFVLLVAVTPAIQSLLVKFEVFTIATCGEMPVWSCNPANIATVVGLDPEPAALEYFPQSLAVQQVAKKTQLVSELDVQPYLWPEHWTSISDAEAIETGTFLWYDEAFPSEKYFVSALQNGTNTGVLREHALRLNSTSACVTVPASEFPQTCPGDRPFVTNLTAPDTLDIRICVPGVYGQTPWTLSRDRQDISEEMWIDVVPQLWEYDINQYNFTLRCTTNSTRGYFEISNYRNNDNPGPLLEKWPSQEELEKDFNDYLGVGGDFAIPSVINNDTDSNLFILGPAPADPFNIEELYAAGPLMTSALALFGNQSFFSVARNATNSSTARSALSSICLFDAIPFTRLDSEGFSTALDTCSELQWMLDNEDNDVFYLQLMYTVYTWIASFSENQTATTALNIATYFANEAVLTNTAAQGYTHNSREIYFDSGTVLIRPRWTLAGVITVSILIGLQVLGLCLIIAYCYSVPTWTGSFDAFAMLRMGAELQRVQHVRFAGIRDTDKRDLAALTRIDGLVGVVDNHEQREPEERHGAKENPPLVNQLVGESASTEIDFNESQTVYSGVSVDGDKSGEDRDERAKEEGLEPPFHLAVGAPGLITKDLVPGRKRRWNRTKVTKTEDGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WIL0</accession>
    <name>A0A317WIL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_547059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WIL0"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY85885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="102" mass="11872" checksum="DD7ED536EB53AAA7" modified="2018-10-10" version="1">MAGAIGKKKDKWYDRWRVIKQEWCGEQGFPSAQPYLSHTPGGLFGFDRSTHHQNKTETSRPCMSRTPAIPRHARLSMIVFTRFYNQMTLELDSEEYTMVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKL5</accession>
    <name>A0A317WKL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PUA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467232.1">
        <property type="nucleotide sequence ID" value="XM_025611709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKL5"/>
    <dbReference type="STRING" id="1450535.A0A317WKL5"/>
    <dbReference type="GeneID" id="37113852"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="42"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="129" mass="14155" checksum="CB21832496179583" modified="2018-10-10" version="1">MATSIPRSSLLSLGVAIGRFTKSGLFRLSLTALDVIAPHARYKVWIKQNGVMPFLYGSNVAKAHVGRFSEDCPENAGVIVMDMNDTPLGFGVTARSSAETRRMEPTANVVFRQADIGEYLREEDTLFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKV2</accession>
    <name>A0A317WKV2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Poly(P)/ATP NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_535819</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466704.1">
        <property type="nucleotide sequence ID" value="XM_025611871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKV2"/>
    <dbReference type="STRING" id="1450535.A0A317WKV2"/>
    <dbReference type="GeneID" id="37114014"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000033">
        <property type="entry name" value="NADH kinase, variant 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF26">
        <property type="entry name" value="NADH KINASE POS5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY85687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="444" mass="48372" checksum="5FE281B21D139257" modified="2018-10-10" version="1">MHFATIRLQPARLRAPSRMPWTRTFSSSSQRYEIRDVGLLPQRLIPKYQESQVGDLLSLQWPAPPRNIFLVKKDYAPAVTASLIEFANHATSTYPSTSIILEPSVAEEVHSLLQSPVYSASLDQPWPVLHDKVDLTVTLGGDGTILHASSLFATCYNVPPVLSFSMGTLGFLSEWKFAEYKRAFREVYMSGAGAGDRGTVLGDPRPASDDESLELGAGPTGWSSVRGKSMGLTRGARILMRNRLKVGLFTADGQPVQRGSKSVGMPNSLDEQGAYVMNEVLLHRGKEPHLAVLDVYVGGRFLTEAVADGIIISTPTGSTAYSLSSGGSIVHPLVPAVLLTPICARSLSFRPLVLPSSTPITLRLSEKNRSRELEVSIDGVNLGQGLTAGMEARVWDEEMRHGKNEWQKGVPCVMRRITGGEAHDGWVGGLNGLLKFNHPFGEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLF9</accession>
    <name>A0A317WLF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">HORMA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_535709</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467132.1">
        <property type="nucleotide sequence ID" value="XM_025611847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLF9"/>
    <dbReference type="STRING" id="1450535.A0A317WLF9"/>
    <dbReference type="GeneID" id="37113990"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="16"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY86541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="226" mass="25371" checksum="732FB0D05738AEC0" modified="2018-10-10" version="1">MSSTKDKSKVHKLSLKGSSKLVAEFFEYSINSILFQRGVYPPEDFTTVKKYGLNMLVTADDQVKAYIKKIMSQLNKWMMGGKISKLVVVVTDKETGEHVERWQFDVQIFGKQSKSQTSRASGDKENATPGDKDPQAAATVDKTEKEIQDEIQAIFRQITASVTFLPVLDGDCTFNVLVYADADSEVPVEWGDSDAKEIKNAEKVQLRSFSTNNHRVETLVSYRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WME4</accession>
    <name>A0A317WME4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HypA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_556914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467033.1">
        <property type="nucleotide sequence ID" value="XM_025613901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WME4"/>
    <dbReference type="STRING" id="1450535.A0A317WME4"/>
    <dbReference type="GeneID" id="37116044"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49714" checksum="5417664FE59FB634" modified="2018-10-10" version="1">MASATAKNIHLSSTEKGIISHHAREDSARAVSDVLQEDMTSHHVFFNQMGFHNHIPHHILSIYALGATPEQIRAAYTSNKSYQRPALRVDEKIVRDMADVGTFLKYLGQGEHYSDYLAFFQHEIEGKGVERVLKEYLFSGEKVAERLLVMLFGGLIHPFIHLGFGIEFNQPALVAQGLAQTAVHDEWTGPMFFWPAEKAAGGVGKPGKKSMLQILEEIRADEKLARSARWEDSGRMENGVLKRAPEEMIKYAAQFTVSEEQIEEKTAEIINTVAYFASAAQRPDKQIKLDFFYLHGVTSSIFLSKIITLPFLDARTKARLLEWTGRLDLMLYVGYGTADLRLDEVTNYPATKSWETIFDYSTAQASDDGHLPKLVRALKNGEQACRPFEDRAEELGLKIKGDMWLKIANMVMDSTSGQSSLWVRGAGFDEAWKEFGERSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WML3</accession>
    <name>A0A317WML3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_85192</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467103.1">
        <property type="nucleotide sequence ID" value="XM_025617707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WML3"/>
    <dbReference type="STRING" id="1450535.A0A317WML3"/>
    <dbReference type="GeneID" id="37119850"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="486"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="869"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="742"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY86512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="898" mass="101269" checksum="6F9F6D31BCC1B3D2" modified="2018-10-10" version="1">MSSPLRPSNSAANRGLGNLGRRKRSREPDDETSSVVPPSSPPPSSPPMLPFDDDDNERDEEAELLGDIDDIDEMAEDEDGIDLFGDNFEKDYRSTAEDQYRGEYIDDDGDHEELDMATRRQLEARMNKRDRELERRRRMPAAFLQDDEDGDLDLTRQPRRRRHHYDEDREDVEMGDDALEELSLEELTDVKAANLTDWVLQPQVLRSIYREFKSFLTEYTDPAGASVYGNKIKTLGEVNSASLEVSYAHLLETKAALAYFLANEPTEVLKVFDQVALDVTLFHYPQYHDIHNEIHVRITDLPVSYTLRQLRQSHLNCLIRVSGVVTRRTGVFPQLKYVMFVCGKCNITLGPFQQEASAEVKISYCQNCQSKGPFSVNSEKTVYRNYQKLTLQESPGSVPAGRLPRQREVVLLADLIDSAKPGDEIEVTGIYRNSYDAQLNNKNGFPVFATIIEANHVVKSHDQLAGFHLTEEDEREIRALSRDPEIVDKIVHSIAPSIYGHLDVKTAVALSLFGGVSKEAQGRMSIRGDINVLLLGDPGTAKSQFLKYTEKTAHRAVFATGQGASAVGLTASVRRDPLTSEWTLEGGALVLADRGTCLIDEFDKMNDQDRTSIHEAMEQQTISISKAGIVTTLQARCAVVAAANPIGGRYNSSAPFSENVQLTEPILSRFDILCVVRDLVDPSEDERLANFVIESHHRANPARPLRDQDGNLINTDGQAIDEEGYRIDKKTKQRLPLTDEELATRDAEKHRREEEKEGEIPQELLRKYILYARERCHPKLYQIDQDKVARLFADMRRESLATGAYPITVRHLEAIMRIAESFCKMRLSEYCSAQDIDRAIAVTVDSFIGSQKVSCKKALSRAFAKYTLSRPKPQSKRRAGIPAPDPFKLRMQSSTRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMY7</accession>
    <name>A0A317WMY7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466989.1">
        <property type="nucleotide sequence ID" value="XM_025611813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMY7"/>
    <dbReference type="GeneID" id="37113956"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43781">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43781:SF1">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="335" mass="36142" checksum="9C8A72AB01E95468" modified="2018-10-10" version="1">MPSFIIYGATGYTGRMASEQAIRIGLDFAIAGRTEQKLKKLASQLQVPYHIFDVNQSTVIDQTLKNAYVLLNCAGPYRHTARPLMEACIRTGTHYLDISAEITSYQQAQELDETAKEAGIMLLPGCGGSVAMLDCLASHALDRVRNPKRIDIALHVAGSMSRGSAMSATGTVAETLHLLDGNLVEYDISNTAEFDFDDGNGPVAAFPVTLPDLLTISRSSNVDNIRTFAHASGGSFPTGDLEMLPDGPTAVERDAAPYHAAVMVTSEDGHVTRAVLHTVNGYTFTSLASVEAAKRVLDNQTKPGFQTPALIFGKDFLRAIPRTEIKITIPEDEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN07</accession>
    <name>A0A317WN07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_466494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467309.1">
        <property type="nucleotide sequence ID" value="XM_025608164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN07"/>
    <dbReference type="STRING" id="1450535.A0A317WN07"/>
    <dbReference type="GeneID" id="37110307"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="259" mass="28752" checksum="DCBC18182A9D5642" modified="2018-10-10" version="1">MTSIKPPCHLHNYARSADPENPGNHANVLMLHGHGQSMDIFYHKTHFLQDALNVGGSPASQPLPNLRLYYSEAPFDVNIPGLGSKVWGYGLFDTQRIGGLERSVGRVLQQLEQLNPVVGIVGFSTGATLAMIIASLLEKKDRCRLFGVHTTHPPLKFVVAYSGFMLGHPMYRELYSPAICTPVLLYIGELDTMIPPNATYRLAKRCSQAEIRTFWGTHFVPRHVKTTRVAINFVCRCVNGEIHAENADEAQAEDGWIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN12</accession>
    <name>A0A317WN12_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_534856</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRP1/MDG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467647.1">
        <property type="nucleotide sequence ID" value="XM_025611635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN12"/>
    <dbReference type="STRING" id="1450535.A0A317WN12"/>
    <dbReference type="GeneID" id="37113778"/>
    <dbReference type="OrthoDB" id="5873279at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF81">
        <property type="entry name" value="CRUCIFORM DNA-RECOGNIZING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="444"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="572"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="607"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY87864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="704" mass="71374" checksum="911E68BF8B9BE9E4" modified="2018-10-10" version="1">MGSFTFRWPYNANEVFVTGTFDDWGKTVQLDRIGDGFEKEVPLPTTDEKVHYKFVVDGIWTTDSGAPEEDDGSNNINNVLYPDQIKEESTSPLLNGTTAMAGVTPDSTTVALAAGVPKESSSRYGQNGYYPTISSAAPGSTTAGLGQDVPLEQRASVPGSYPATPASETEKFSVNPIPASSGIGNPIKLNPGEKVPDASTFGQNTIHSTARTDKAGYEQGAGAFPGSSNFDESAFAVPPVSKNMIPESSLPMGEGQEATKPIYTIQSITPMSTTAGLAAAVPLESQKQTASGLPATDVPDVVRQSLSEAHRDPEAATSEAAVEEKREMEDELRQKVPVDNSPGTPAPAITAAAPLGSQKQATGVPARDVPDVVKQSISEGYRGPEAATSEAAVEEKREMEEELQQKVPVDNSPGTPAPAITASTATGLGAGLGAAGLGTAAGVGAAASLESQKQTTDGLPAEDVPDVVKQSISEAHEDPKAATNEAAVEEKREMEEELQQKVPVDNHAGAPAPALTAATTETAPRATGEAAPAGTAGTAGTAGTVGTAVTTDTVPRATGEEPASEQISPRATSPTDGPTVTTGVGASKVPEVSGPASDRGDASNDISTTPAAGATGASATKTVDSGVESGPTAEEPTAPTAGATGTSATKTADSAETGTSGEAASTGATNGAASKTNTAGSNGKEEKKKKKGLFSRIKDKLKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNB5</accession>
    <name>A0A317WNB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_535375</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467469.1">
        <property type="nucleotide sequence ID" value="XM_025611765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNB5"/>
    <dbReference type="STRING" id="1450535.A0A317WNB5"/>
    <dbReference type="GeneID" id="37113908"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000002">
        <property type="entry name" value="Sphinganine-1-phosphate aldolase Bst1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY87261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="572" mass="62042" checksum="E50B884C39AA0502" modified="2018-10-10" version="1">MASSLLPAALQNKLLGYSRAPSTQLAALPLDLLRNIVFILFILRYVRKTFYSLRGYGIFGSIRNVYASVRLFFYSVFLRFPGVRGQVDKQVSTAIEGLESKLIASGPGVTRYLNLPKEGWTAEQVRAELDKLANMEHTRWEDGRVSGAVYHGGQDLLKLQAEAFGQFGVANPIHPDVFPGVRKMEAEVVAMVMALFNAPSDGAGVTTSGGTESIIMACLGARQKAFLERGVTEPEMIIPDTAHAAFYKACNYFKIKLHRVPCPAPEYKVDIPAVRRLINSNTVLIVGSAPNFPHGIVDDIPALSRLATAYKIPLHVDCCLGSFVIAFLKKAGFPSPYEEEGGFDFRLPGVTSISVDTHKYGFAPKGNSVLLYRNKAYRSHQYFIYPDWSGGVYASPSVAGSRPGALIAGCWASLMSVGENGYIKSCLEIMGAAKKFEASIKEHPVLSKNLGIVGKPMVSVVAFDSTNEAIDVYDIADNLSAKGWHLNALQTPPAIHVAFTVPTSAAVDALTSDLVVVVEKELAKAEERKQQGKAYVVKRGDTAALYGVAGSMPDKSIVSRLAEGFLDTLYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNP3</accession>
    <name>A0A317WNP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_491961</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467776.1">
        <property type="nucleotide sequence ID" value="XM_025609169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNP3"/>
    <dbReference type="STRING" id="1450535.A0A317WNP3"/>
    <dbReference type="GeneID" id="37111312"/>
    <dbReference type="OrthoDB" id="17199at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000003">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF0">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="10">
        <location>
            <begin position="106"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY87993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="220" mass="24487" checksum="E5D81E711D04C03C" modified="2018-10-10" version="1">MSDSNNPGLDTQKHLFIYQQQQATASSSSTQQPSTPASTKDDSVPAGMTKLPNGVILDKDGKPCRLCTSAASWRALTKQAKSTPTTTAAASTPSSTTPTTGSYTDCPPDSEALGRSTWTFLHSLTASYPVRASNEQQSEMRTFLGIFSRLYPCWVCADDFRNWMAEPSGANEPRLNGRQEFGDWMCRAHNEVNRKLGKKEFDCRLWEERWRTGWKDGRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNX1</accession>
    <name>A0A317WNX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_535125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467919.1">
        <property type="nucleotide sequence ID" value="XM_025611707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNX1"/>
    <dbReference type="STRING" id="1450535.A0A317WNX1"/>
    <dbReference type="GeneID" id="37113850"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF2">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE PYRROLE 2,3-DIOXYGENASE (AFU_ORTHOLOGUE AFUA_5G01450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="39"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="438" mass="46985" checksum="1626B11165349582" modified="2018-10-10" version="1">MGSINQAPRVIQSEQTPYFTPANNGGAALNPADPDTPTLFRPLQIRDVTLKNRVVVSPMCMYSAESDPSSPLLGALTDYHIAHLGQFALKGAGLVFVEAQAVQPNGRISPNDVGLWDHSPESEQFKSLQRIVRFCHSQGAKVAVQLAHAGRKASVVAPWVAAEAKKAAIIAEESVGGWPSNVVGPNGGVEHTWGPGYCTPRALSVEEIQELVQAFAKSAEAAVRAGVDVIEIHAAHGYLLNQFLSPVTNKRTDAYGGSFENRTRMLREVLTAIRAVIPTGTPLFLRISATEWLDGQDVAAESGTWNMESSLRLLPLLPELGVDLLDVSSGGNHKDQKINLHTNYHIDLASEVRQAIRATGAKTLVGAVGFITQAEQAQGLVQGADEAHAANATVSGPEPVADLVLMARQFMREPEWVMNAAKKLGAKVDVPVQFRRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPI4</accession>
    <name>A0A317WPI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_466400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467380.1">
        <property type="nucleotide sequence ID" value="XM_025608159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPI4"/>
    <dbReference type="STRING" id="1450535.A0A317WPI4"/>
    <dbReference type="GeneID" id="37110302"/>
    <dbReference type="OrthoDB" id="2943660at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="305"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY87172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="675" mass="75591" checksum="D9928CFDE44926BD" modified="2018-10-10" version="1">MEPTSGERPAKRVRQACEPCRRKKAKCPGEQPVCSLCSRLNQRCAYAGEHRRSLTAGLAVSGEPAPTPSNSESKLSQILEERLGNLEARMGQVLDALGQSTTRQEQRATAPTASISSAMASSMLNPTTPFPTWEKVMSIAELYLIYCDAQPLPLFYRDSFLSTLGSRDPEIIYAMLALSIRFSDDISFTTNDLTSIINGYTEVARGLVMKRVSEGPIELSTLQSLCLLSLVDFANGNAHRSSIHCSLAMNLAQCANFGSESHLVQSPTAREERRRCFWSICLLKRLHGVDFDNLDFADGCFPPFPESPSRPAPTSSLSDGTNETRSSGMQDQGIIAYVIMLSEIFAKAARYVRRHGRPSNVPPWSSQSEYSKILTALMERETQMPYSHRFKPANLSERTFDDLQGKRDYWGPWLLNQFLYHTILCLLNHPLLLSLSLRNFRSTIPEIFLQHTSDLISSHTTWIIHFIDYFEERSFIVSDPFMGYGAAVVATIELQLSFTENTTIREEKRNRFSKCVGFVQTLGNKWPHMARLADRLQRLEDAVSASYELESGAQNKYLLIDLSRFWEILEYSSSDADSARRMFGDSLYTEAPTLGAEVSQTSPLPEPFRLHSQQTTSQSPTSQFNIQTPLATGVQYPMGVGSPLHDEFSILAANFFSQAQDFLRSGDPRDGFGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQH3</accession>
    <name>A0A317WQH3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear elongation and deformation protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_534547</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468018.1">
        <property type="nucleotide sequence ID" value="XM_025611576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQH3"/>
    <dbReference type="STRING" id="1450535.A0A317WQH3"/>
    <dbReference type="GeneID" id="37113719"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="439"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="634"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="642"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="720"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY88656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="750" mass="82444" checksum="2D26ADD8F7A7071A" modified="2018-10-10" version="1">MQYVRSISGSVSKTWNSINPATLSGAIDVIVIEQEDGTLACSPFHVRFGKFSLLRPYEKKVEFSVNGIRQNYAMKLGEGGEAFFVFETTDEIPASLQTSPLVSPTSSPKMRSEENLPPSLQEPDYLDLDRTNGSTALPMLSRGMRATSDLGTITPLSRSPDDSSLGRSRHGSFGDEPKQIDRTVTDTVLLTKSRSNSVSVADQVYGLQSPGASASSDDVGPDGRPRSPPLLSPEEAMSRAVSLSKKLSGSNIPSRVTETGDLMLDMTGYKSSEEDALRAEVLARKILAEELEGSYDIGALIGADEHGNLWIYSSEEAKEAANRRATFNAMRPSSAMSEHAISDPGYHSDSDRSINDKPMPTRHHRAQSDVQPGFPTPPQSPTQEPLATESARNYAKTLRLTSNQLKALNLKPGANNMSFSVNRATCTATMYLWNGNVPIVISDIDGTITKSDALGHVLNMIGRDWTHAGVAKLYTDIANNGYNIMYLTSRSVGQADLTRAYLYGVNQDGYRLPKGPVIMSPDRTMAALRREIYLRKPEVFKMACLRDILNLFNGKENPFYAGFGNRLTDALSYRSVNIPSTRIFTINSNAEVVLDLLSLNKYKSSYVSMTELLDHFFPPVSLLVQAGGEEYTDFTYWREPPPDLEDFSCTDSEAEEGDQEEEEEEEEEEEEEDYDGELSEEDGSDVEEDEAGEDLGASYISQDSVDGSELADSRSLQIDEGVEEEDEVLSDEEPVVSPRLTKSNPGSPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQW3</accession>
    <name>A0A317WQW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_574830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468185.1">
        <property type="nucleotide sequence ID" value="XM_025615039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQW3"/>
    <dbReference type="STRING" id="1450535.A0A317WQW3"/>
    <dbReference type="GeneID" id="37117182"/>
    <dbReference type="OrthoDB" id="2519291at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="12"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="143" mass="16612" checksum="1B4AAC4FDC19701A" modified="2018-10-10" version="1">MPFQILLLAHRKPTLSPTTFHTYYESHIELLKRVTGSDFPLSHRRSYIARTTTTTNTPPSPTSVEEASHPATLLLGQQSNFPFDAIAELTFEDRAAFERFTAKIQEPENKRLIEEDEERWSDGGGWGLWFWGRWLLRNDNYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WR37</accession>
    <name>A0A317WR37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_595287</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468265.1">
        <property type="nucleotide sequence ID" value="XM_025616224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WR37"/>
    <dbReference type="GeneID" id="37118367"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF18">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="205"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY88903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="367" mass="40622" checksum="FAA5CD8661835FE9" modified="2018-10-10" version="1">MSTPQNIPIPDAGKKVLGTVTLAPALGFVPIAVHFDLFGCLQDVGKPATAGDVCDVHRRKYGDTDLYDALFMMGGLGFLDLLPDDVYVANDVTKYLVNTPSAQHGAMHFTSEGLLGAAFLMRQLQDTNYRYPFQECETPFQYAYKSMGDEFLAKEHVYSVMHHTGRLDSFNTFMTGKFGRWGTMPDRVRKLGYDLDGLLESATPEILRIVDIGGGRGELLLELKATYPHLLRKENLILQEYNADIGVVPDVTEMGWNYKEDGSEQPVKGALLYSMAHVLHNLSDIESIKLLAKVARVMAPVSRLLIQELTKNAASATTHAAMIVMHAGRERTSAEWKDLAAFAGLEVTFEAYPPLGECVVEMRKVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WS97</accession>
    <name>A0A317WS97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_535017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467790.1">
        <property type="nucleotide sequence ID" value="XM_025611675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WS97"/>
    <dbReference type="STRING" id="1450535.A0A317WS97"/>
    <dbReference type="GeneID" id="37113818"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="86"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="212"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="35728" checksum="BE4B453B3CEE5C77" modified="2018-10-10" version="1">MSSSSSSRSGSRPPPQSTKNNNNNNNNNNSTTSLQQSAASYFSYPVTHVVSGLYRRLTDPPSNNTNSNNTMRRKTDQVYTPVRTASPFQPPPLTPSPSPIPPHYSPGLWPKKFAFSLDRDGASLSTLYDHCRDISARSPRAGYVLVIRDASPSSTAVFGAYMTDPPHPDSHYYGTGECFLWRASVLPPSTAMLNFTSDMDGAGAEALEKAGFPLPPSADTTNAGRSTTLRTGGGEKWLSPGTASGTASGRTSGTATPEQIRFKAFPYSGVNDYMIFCETGFLSLGGGDGHYGLWVDSSLEKGVSASCQTFGNEPLSDEGVKFDIIGVEVWYVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSF5</accession>
    <name>A0A317WSF5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nuclear transport factor 2</fullName>
            <shortName evidence="4">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_534790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467581.1">
        <property type="nucleotide sequence ID" value="XM_025611624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSF5"/>
    <dbReference type="STRING" id="1450535.A0A317WSF5"/>
    <dbReference type="GeneID" id="37113767"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00026247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00053082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY87798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="123" mass="13900" checksum="1D7948708E86385D" modified="2018-10-10" version="1">MADFSNIAQQFVQFYYNTFDSSREQLAGLYRDESMLTFETSSHLGVAPIMEKLLSLAFQKVQHQISTLDAQPSIEGSIIVMVTGALLIDEEQRPMNYTQTFTLKPDGAGSYFVFNDIFRLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSV3</accession>
    <name>A0A317WSV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_585861</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467518.1">
        <property type="nucleotide sequence ID" value="XM_025615718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSV3"/>
    <dbReference type="STRING" id="1450535.A0A317WSV3"/>
    <dbReference type="GeneID" id="37117861"/>
    <dbReference type="OrthoDB" id="1920692at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY87310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="87" mass="9946" checksum="FB2B902DCE72B9F1" modified="2018-10-10" version="1">MGVPFEALLPFGIIIASFSVGSAGLWAVKRYANEGKKARWNRDLWDRSTLMERDYRITGTKRGQSSNPEAPKGFELSNPWKLEKRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTK0</accession>
    <name>A0A317WTK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_584687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468336.1">
        <property type="nucleotide sequence ID" value="XM_025615645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTK0"/>
    <dbReference type="GeneID" id="37117788"/>
    <dbReference type="OrthoDB" id="10530538at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="247" mass="27886" checksum="BCED04324DE63033" modified="2018-10-10" version="1">MSDFYTRKAFRSIIVCPAPEDFFPFELPRPTTEQHFISIDEKSRTERTTSDSTEMKFITRFGKPIISATEMRCNTPVVHKRSSIESRMAADSGKLPVIVEEETDEQAIEDNKAHLGDMAPTEGEATNTSEQDISDDKVHRNSMTASANKELVITIDDPPAVPEKAHSRIPVPPGENVPKVRNLSSLFKVKIYPVMMRAMTERSKATGVKGRLIERGKASNKEVLLWIAVAMFWMMMHFGTWRSCKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUM8</accession>
    <name>A0A317WUM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_38999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468432.1">
        <property type="nucleotide sequence ID" value="XM_025607315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUM8"/>
    <dbReference type="STRING" id="1450535.A0A317WUM8"/>
    <dbReference type="GeneID" id="37109458"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY89521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16676" checksum="A10EE0621EEAA025" modified="2018-10-10" version="1">MSIVLQQSAHYDRLQGIERSDAVHFEHFDRQHISSEFPQAGDAIADRLGLAILQRSAIHRYRERHHLKLGQALNHALSDHPDSVSTRLSETVATEFAETMHIDHNLDSESIVSQTSYAETLINGSEGMVIPPPPPESVHGNPFKCSCCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUP3</accession>
    <name>A0A317WUP3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_545680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467930.1">
        <property type="nucleotide sequence ID" value="XM_025613254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUP3"/>
    <dbReference type="GeneID" id="37115397"/>
    <dbReference type="OrthoDB" id="4301468at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016346178" evidence="1">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="192" mass="21200" checksum="F57C7A8F8F344CE7" modified="2018-10-10" version="1">MKFTIASTLVATTSLLSVANAQFSLPNIPETCLEIPQVLGNKPLQLLSYFHKEVCEKNCTATINQHNQYLQQSVFPQIMKDLDQKLDISASEQASFQKIQTQVEAAIKKDCVAEGNKQLCNDLEGLADYGLCVLKATEPIIKQNIGQLKSSVNITDADCAKIKSIDSDATVWQKTLPAYVDKFAQICESEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUS0</accession>
    <name>A0A317WUS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginyltransferase</fullName>
            <ecNumber evidence="2">2.3.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_534337</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468472.1">
        <property type="nucleotide sequence ID" value="XM_025611521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUS0"/>
    <dbReference type="STRING" id="1450535.A0A317WUS0"/>
    <dbReference type="GeneID" id="37113664"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="5">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="6">
        <location>
            <begin position="176"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY89561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="438" mass="50749" checksum="AF0F4C21CF646A55" modified="2018-10-10" version="1">MEPIVDAEQARKLSLFRPLGYQRNSCGYCKSDNGSASYYTSSLSVRPAHYESLVNRGWRRSGTLYYKQNLQRSCCPHYTMRLEASAFTPRKDQRKAINRWNKFVLGPEYIRRAAYLCPKTREEKKHRKCNFDVLGVVHEAEYNNVKRPIDPKTKKHLEPAHRFEVNLEGDSISQAKYELFLKYQTAVHKEDVSKWSNKDFKRFLCSGLTRSPANSAKSDEKKLGSWHQCYRLDGKLIAVAVLDLMPNGVSSVYIFYDPEYEQLEFGKLSAVREIALAVEAQYQYYYMGYYIHSCQKMRYKGTFRPQYILDPETYTWDPLDGELSKKLDEWPYVSLSRDRQPNTNPRDDRAEADAEINDEEVSLFDLHMPGALTIDEVKALDLDHWFLLYHGSFVHMIDLVGWETMPLNNPQSVKGIIAELAAVLGPEIVQHSAVVLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWW3</accession>
    <name>A0A317WWW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_463277</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468903.1">
        <property type="nucleotide sequence ID" value="XM_025608015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWW3"/>
    <dbReference type="STRING" id="1450535.A0A317WWW3"/>
    <dbReference type="GeneID" id="37110158"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000006">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019807">
        <property type="entry name" value="Hexokinase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00378">
        <property type="entry name" value="HEXOKINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="10"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="228"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY90525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="494" mass="54613" checksum="5DB2ACDDB1F21A6D" modified="2018-10-10" version="1">MSSALLDEATRIARQFDYPAADVRRGVTEYIREIDEGLSKEHTTLSQIPTYVTAVPNGTEKGLYLAVDLGGTNFRVCSIDLHGDTTFSLTQSKIMIPRETMASGTAKDLFLFLARQIEAFLRIHHNEHFEAHLRRRNEKNGNCEEDLFDLGFTFSFPVRQLGINKGTLIRWTKGFNIPDAVGQDVCALLQSAIDELELPVRVAALVNDTVGTLMARSYTSPGETGTFLGAIFGTGTNGAYVEKLDRITKLQTIEHSSYDKTTGEMIINAEWGSFDNHLSVLPNTIYDQQLDADSNNPGIQMFEKRVSGMFLGEILRRVMLDMYRNPSLGFLKSSESTVSVPKESSLYRQWGIDTSLLSLVEADKTEDMEQIKTALRDHLRIQRPSIADCKAIQTVVHAIGKRAARLSAVPLVAVLISTGKLQRDDLVDIGVDGSLVEFYPNFEGYMRDALREVPEVGEAGNEKIRIGISKDGSGVGAALIALVASKEDARRKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYJ7</accession>
    <name>A0A317WYJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_393535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469171.1">
        <property type="nucleotide sequence ID" value="XM_025607338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYJ7"/>
    <dbReference type="STRING" id="1450535.A0A317WYJ7"/>
    <dbReference type="GeneID" id="37109481"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16084" checksum="E9A39705D4B5D5CD" modified="2018-10-10" version="1">MSAFMSSLRPALRASSGAALSARSFSSSSSRSVARLMITGRLAAQPELQATSSGQEVVKYTVASSHGPKDRRQTSWFKVSAFVEGNQREYITNLQQGTLVFVEGDASIRQWEDAEGKRQSALSIVQRAVEVLKRPYSETSAEHDNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYY0</accession>
    <name>A0A317WYY0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_462586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469307.1">
        <property type="nucleotide sequence ID" value="XM_025607980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYY0"/>
    <dbReference type="STRING" id="1450535.A0A317WYY0"/>
    <dbReference type="GeneID" id="37110123"/>
    <dbReference type="OrthoDB" id="2431049at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.80:FF:000001">
        <property type="entry name" value="Chromosome segregation protein (Pcs1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="3">
        <location>
            <begin position="405"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="514" mass="56115" checksum="2B1E7A4AFD09B1D4" modified="2018-10-10" version="1">MPKRKAAAALSGPAGSGDEGMQANDSGRERPTKKQRGRPRSKSAELKPLAQSARESSIPAPSEAPVKKSSRRGRPKGSRNSVQASQEAAEEQVEVAESQPEVGDQGAESAPVSNDELDGGSQSVTKSARPTKSTKPLPTRSRKNATALSSVQTDGGFEYTPSSSRQRKSLDKPEERPEPPKRQRRKAEAEENKDVPVEDSAAPDVVDETMLQDEPIESRSVSRSPTKRRQSVYNSPTKSRLSGTADEPELRRRIGDLTKKCDTLENRYRNLKEIGIVEANANMEKLRKQCESMTNASNNLIASLKAELEAQKALGQQSRSLQRQLKERDAEVARLKTQAEEATGQLSSTQTEVKALQTKLAAARNTAASLESAAARVPGSAIKSGANRANAAITAEAAHAAQFAQLKEDLYTDLTGLIIRDVKKRPADNLYDCIQTGSNGTLHFKLVVPHVSSANFESAEFQYIPLLDENRDRELVDVLPEYLTVDITFVRQQASKFYTRVIDALTKRRSTAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ52</accession>
    <name>A0A317WZ52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_554875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469387.1">
        <property type="nucleotide sequence ID" value="XM_025613749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ52"/>
    <dbReference type="STRING" id="1450535.A0A317WZ52"/>
    <dbReference type="GeneID" id="37115892"/>
    <dbReference type="OrthoDB" id="4691160at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016396447" evidence="1">
        <location>
            <begin position="20"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="114" mass="12538" checksum="C21953D544C30CE5" modified="2018-10-10" version="1">MQFTVLFYTLVALAISALALPTGDTREIQLRLWSENGCAEENLGELGLYRSTLNQCTTFLGSDTIRSISTEFVIDGYAAQFFTDSDCQEGQQNVTTTGCLDGDAPYVSYKLVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZQ9</accession>
    <name>A0A317WZQ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_617531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469604.1">
        <property type="nucleotide sequence ID" value="XM_025616832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZQ9"/>
    <dbReference type="GeneID" id="37118975"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050349">
        <property type="entry name" value="WD_LIS1/nudF_dynein_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44129">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY91876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="22090" checksum="B589667460A2BCE6" modified="2018-10-10" version="1">MGFKRYVSREGTVQFWDPDTTHLRSGMSIGSTTVATSPPDGRLLFAVSEQGRLQVWNLARPTFRTSFEDADLEYWGTDTCVAWLPQTGTHVMVASTKGIRIWEASTGKLQKKFESSEDQSLPFKQFSTKMTISPHGNLILAYHSSALILEWISGASMVGNDLVHKTGSFRALSPNGTFMITVERNSLLVWDMKTQGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X025</accession>
    <name>A0A317X025_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_544983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469353.1">
        <property type="nucleotide sequence ID" value="XM_025613209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X025"/>
    <dbReference type="GeneID" id="37115352"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="216" mass="25289" checksum="51FB9253A66775F7" modified="2018-10-10" version="1">MTLINRKKEYYKCFDQRNSNRLAVIITFAYLQGFQDKDERGLEGKVIEENNNKNMEYAGKRERSSGQHGRHKRILRHHGGDLDRRSGGVRVNLPERRPEENQWQYELWDGHSHIPKGAFTTSRRKCDRITLEEQYRVNTLFERKEDKMQIIHVAKSSEEGPGGETEWKKKAITESLMWGTKGNQSYLSIYTYVCDAEGRYYSGKIKGAENPRLAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0D8</accession>
    <name>A0A317X0D8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_555440</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469359.1">
        <property type="nucleotide sequence ID" value="XM_025613796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0D8"/>
    <dbReference type="STRING" id="1450535.A0A317X0D8"/>
    <dbReference type="GeneID" id="37115939"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016331416" description="laccase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="66"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="189"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="405"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY91631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="562" mass="62065" checksum="34DD6F4E56A28F03" modified="2018-10-10" version="1">MYFHSFLTASLIAATGVHGISPPSNPCAGNTPQTRDQWCDFDIHSDYYTEAPNTGVIREYWLELGNTTAAPDGIPRNVLTINGTSPGPTLYADWGDWVRVHVYNGLENNGTSIHWHGVRQNHTNPQDGTNSISQCPTPPGGSVTYEWRATQYGTTYYHSHFALQAWEGIYGGIVINGPASSNYDIDASILYLSDWSHRTSDQLYSTAETDGEPTLATGLINGTNIWVKQNNETVGSRFTMNVTAGQSYRLRLLNGGMSNLFRFMIDNHTLTVIAADFVPIEPYNTTSLNIGVGQRYDVIVTANQDAIGSDFWMRAIPQEACMEIENTDIRGIFHYANPGNEIATPTTTPFGYTDSCYDEPLTSLIPMVAIDASGVGYTSHNDVNVIENTAGLYKWYMGPTTFKADWNNPTLLQIANGNTSWSNSSHVVQVEGNGQWVIVDIEMAINVPHPIHLHGHDFAILAQGKGSYTTNTTLNTYNPPRRDTAMLPALGYLVIAFKTDNPGAWLLHCHIGWHQSEGFAMQFVESIDQLKPMVDVDVLERNCAAWDRYAVADDIVEDDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3Y2</accession>
    <name>A0A317X3Y2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_370832</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470080.1">
        <property type="nucleotide sequence ID" value="XM_025607207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3Y2"/>
    <dbReference type="STRING" id="1450535.A0A317X3Y2"/>
    <dbReference type="GeneID" id="37109350"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY93319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="529" mass="60348" checksum="4AEE486A12759C12" modified="2018-10-10" version="1">MWSLFSIAPYAFVAGLLGISYFLIWPFVQYMRDPKGLRKYPNLTPFSGMSAIPFMIMASRGFRSRELMELHREKPVIRTGPNTLSYGDVRAIKDIYGHNTKCIKDLSYVVTAGTHYHLADVVDKPDHARKRKVLSSAYALKNLETWEHKVSDKVEKVVAHFDKVCTAAPSEAMATGKVAPDPKDLTVDFRAWTNYFTLDAIADIGLSEKLGLLDSGSDVCVAERKDGTTYEVHLREALYPTARKQSLILWNYEWYPVLNKLVNVIPFFNRMQKSSDNWDNIVWRRSMERLRRYEAGEKLDDFFQALMEDRNGRANNLEWGEVVAEVNIMMNAGSVTTAIAIANVMYQLLRNPWCLAKLREEVDAVLDADEIIAPYDKVKHLPYLRACLDESLRIFPPTSHGLPRETPAEGIEILGQWVPGNTTVSMSAFVAHRDERAFPKADQYIPERWLGEEGKALQPYFVAFSAGARSCIGRNISYLEQTKILATLVHRYEFALAYPGWELKRLETMNLILGDMPVKVWRRSLEATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4P8</accession>
    <name>A0A317X4P8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_346157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470307.1">
        <property type="nucleotide sequence ID" value="XM_025607075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4P8"/>
    <dbReference type="STRING" id="1450535.A0A317X4P8"/>
    <dbReference type="GeneID" id="37109218"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF2">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016191013" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="539" mass="59334" checksum="E894E1E9256DB472" modified="2018-10-10" version="1">MRLSLLLAGAINLVATQAISASHCTPETFTPHLSSNASLVYAVPYGPNDTFVGPLGNYSGLPEYCAVYVNVSSSATSSFEFGLWLPINTWNKRYMAYGNGGFTGMIAFADMAPGVNYGFATVSTNTGHNSSVTQAGDAPWALNDPETRTDWGWRALHGSVALGKELTEAFYNEDITYSYYAGCSTGGRQGLKSVQMFPEDFDGVLAGACAWWTTHQQNWDLKLATYNLPNNASHHITETQVDALAAEVLRQCDGVDGVEDNIIMNGYACDFRPETLLCDGPSANTSTCFTADQIDTVYKIYAPWVETNDTLVFPSFAYGAETQFAQMIMTDDDEQDSPSGIAYPRDFVYNDADWPWQSLDYSTIQLSDRLDPGNATADDFDLRPFKKNGGKLIHYHGFADGEIPTGSSIYYYKQVQKTLIPLGIDLDDFYRFFLIPGMEHCLDSVHDAPWYIGAANQPGGLTGTNIWGVPGYRDRKHDAILALMAWVEQGIAPEELIATKFVDDTPAEGVQAQRRLCVYPKEAKYVGGNWNETSSFECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4Q5</accession>
    <name>A0A317X4Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_462480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469268.1">
        <property type="nucleotide sequence ID" value="XM_025607977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4Q5"/>
    <dbReference type="STRING" id="1450535.A0A317X4Q5"/>
    <dbReference type="GeneID" id="37110120"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="10">
        <location>
            <begin position="406"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="493"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY91540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="524" mass="56805" checksum="2E79A4A0FEB1EB9B" modified="2018-10-10" version="1">MVHSAPVPSSGFQALILCGPGESLNTISSNPEENPKCLIPIALRPMVYYPLDWCKRAGITDIVLITPPSALTPLKAALQQNPYLTSLHSPSPTVIAPKDLKMTTGTAELLRLPEVQACIQSNFLLLSCDLLCDIPGEHLLEAWLASQSELGPAAQGGLSVIYPVKGVQDEIKKEPTDFVAITSLEPDEAPAVSRYELSKLVLSMPMDTLKEQIENDKGLLLRHTLVEKHASVKMLTSYRDAHLYILPKWVRSLAQHQERFESVSEDLIGYWAKAEWQRGLSAKLGIDEILGGRDETQEEQGSNDGDSLEEEVDLRGMTTTHAQGSEARSTNSKPSVEVPPILAYTAKPSKQLIRRVDSSALVLAMSLRLAKLESIEEVGRAAASPFSHASKIATPEGVASKSIVTKGDCLLGSNVTVEEKCVIKESCISANAKICSGARLTRCLIMDNAVIGPKCVLTGCIVGRYSQVGRDSVLKDCEVQDGVVVEEDTDAKNEQFMSFEGLDEDDEDGMDVGDDEDSNDDAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X505</accession>
    <name>A0A317X505_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pentachlorophenol 4-monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_513934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469358.1">
        <property type="nucleotide sequence ID" value="XM_025609864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X505"/>
    <dbReference type="STRING" id="1450535.A0A317X505"/>
    <dbReference type="GeneID" id="37112007"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="406"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY91630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="571" mass="63645" checksum="AD024157C5A9BEA3" modified="2018-10-10" version="1">MSDPIKTDVFICGGGPVGLLTAYSLALQGVTSVIVEKHDTAQQAMYGRAGTLYPRTLEMLDQLQLLDELNQIGYIARNSVTYKNGQLITSRGWHIMYQRMHETFMDYILNIRQKYSEDAFRAAYEKLGGTPYIGWQLETFSVDESCEDDYKVTSTIKNVSSGKTLTVKSKFIVGADGGHSLVRRLANIASEGDRTEFKWVRIDGHFRTDMPDADLGFASIESESHGNVLWVQMDHGVKRIGFAMTEEMLAKYGDNLTLEDAKAEAVKSMAPFTLEFDSITWWTLYSIGQRVAETFVKDDRVILAGDACHTHSSGAAQGMNTGVHDSVNLSWKLGGAIKGWYSPEVLRTYDTERRPAAQHLIHLDKTFSASISGKVPDSYKDQNITADELFTKTFDDNIQFNIGLGIHYDENILNRPSLATMVTAGWRAPDATVYAPGSKFPIRLFQLTKNTGAWSIVILAGHPDKTRKNLTHAIQELQKLQERLPSEMLRFITVVAQAVGGGDQWYQIPKIGRLYYDAERSAHTAYTVSDSTGAVAIVRPDGLLGYATRLDDLSHVEEYFSGFVAPAYMKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X515</accession>
    <name>A0A317X515_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flotillin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_583530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the band 7/mec-2 family. Flotillin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470062.1">
        <property type="nucleotide sequence ID" value="XM_025615565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X515"/>
    <dbReference type="STRING" id="1450535.A0A317X515"/>
    <dbReference type="GeneID" id="37117708"/>
    <dbReference type="OrthoDB" id="6080404at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03399">
        <property type="entry name" value="SPFH_flotillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027705">
        <property type="entry name" value="Flotillin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806:SF31">
        <property type="entry name" value="FLOTILLIN-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13806">
        <property type="entry name" value="FLOTILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="50"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="422" mass="47316" checksum="A1DEA86D87EB83CA" modified="2018-10-10" version="1">MTIEKLQFSLPAVFTIGPDNEQVALRKYALLLSGCAEEASSAQPTDLTNQTRHNHVQDIVRGIIEGETRVIVSSMSMEEIFKERQVFKTKVIENVQNELQHFGLRIYNANVKELQDTPGSEYFAFLSRKAHEGALNQAKVDVAEARMKGEIGEVEKQGRTKQEISKIDADTAVLETQRKAEKAKADSELTNRETELDYNIQLNKITTQRQKEMRDAKLQKQVETKRAETELERLRAEQVTKSKVERESAQEAADAAYYTEQKAADAQLYKQKMEAHAAYYRQSKEADAAFYTQKREAEGTLEMAKAYGALVDVLGGPQAFLQYRMIETGTYERLAEANGCAINGLQPKITTWNTGDTGNGSRDSMAAIRNIMQGLPPILSTIHEQTGISPPSWFAEMPKSNGMDNSLPPKEPRPTNDMLLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X557</accession>
    <name>A0A317X557_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_372224</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470102.1">
        <property type="nucleotide sequence ID" value="XM_025607217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X557"/>
    <dbReference type="STRING" id="1450535.A0A317X557"/>
    <dbReference type="GeneID" id="37109360"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="12">
        <location>
            <begin position="30"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY93341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="317" mass="35266" checksum="90AAB32C3A15D648" modified="2018-10-10" version="1">MVEDPGFVPKVGSRNQQRAVIAELFEQWKFDEENFCVSCMVRKPLRSKHCKRCGRCVAKHDHHCPWIDNCVGSNNLRHFVLYITCLEAGIILFVQLTFSYITVLPAPVNPTCNVINETLCDFVLRDTFTLVLDVWVIIQLVWVTMLCAVQLVQISRNQTTYENMRGHSIDRSYPSSRAFASALAAGTTSFEGAGLSSAGQGPNPALAHGAAHRHQRGGCLQQWTSLLGIDTFFATARDGLRDGPRATRAKNPFSRGVVTNCRDFWCDPAPYFGQREAGSGMLGGEVVNYNQMYEMPSHMHSGGRYRSLAGDDPEQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5V0</accession>
    <name>A0A317X5V0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Lysophospholipase NTE1</fullName>
            <ecNumber evidence="3 16">3.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Intracellular phospholipase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO94DRAFT_621451</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 16">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 16"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470745.1">
        <property type="nucleotide sequence ID" value="XM_025616998.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X5V0"/>
    <dbReference type="GeneID" id="37119141"/>
    <dbReference type="OrthoDB" id="421051at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000062">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000007">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000018">
        <property type="entry name" value="Lysophospholipase NTE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056556">
        <property type="entry name" value="NTE1_P-loop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF29">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE SWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24179">
        <property type="entry name" value="NTE_Ploop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 16" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11 15 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="696"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="18">
        <location>
            <begin position="847"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="19">
        <location>
            <begin position="1226"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="302"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="763"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1508"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="15">
        <location>
            <begin position="1230"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="15">
        <location>
            <begin position="1257"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="15">
        <location>
            <begin position="1377"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="763"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="15">
        <location>
            <position position="1259"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="1377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PWY93984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1529" mass="168725" checksum="8E9666FA64DF83E6" modified="2018-10-10" version="1">MAYDGIIAAPSLESSSLGSGLVPLASSSTSARSLATSHPALTASFSVVSGFSSHLPPPPLPPPAPSTMVGWIGWVFTFVFQVIPSILYWIVTFSTITLPTWLFTLFSMSLTFTMNFTTLLLIALAVVSTISWFIRYRFLNMYSRLPPEPQRKEPQIDLFPDVPEGDTKPGLANYLDEFLSAIKVFGYLERPVFHELTRTMQTRKLIAGETLLLEEEKGFCLVVDGLVQIFVKSVRDRKSGTEEDFTRMAGESSDDDDHRMDGRQGYQLLTEVKNGASMSSLFSILSLFTEDIQLRYADSSASSTSSIGLGPARAPDSFPASPEGMADFPHALPRDDVDPMSNIGSSTDDLPAVPPLHLGESQVPPADSSRSENERHSGKTRRKSVHPDIVARAMVDTTIAIIPASAFRRLTRVYPKATAHIVQVILTRLQRVTFATAHSYLGLNNEVLGIEKQMTKFTTYDLPNDLRGAALDRLKDKFIKERDRLGHEEVTKGIALHNPYAGRRPRSSSFRRKEAVLQARMAASKRPVSMVAHDNALSDRENAGVSPGDLLSTIQLSRFGPRYEHLAPRLLSPLTEKEHSPLRSPSPMLPGRGSPFHRKESIDEDALFRESILECIMKGIGLTGSTNDFLRKSSHASGDASPKLLSYDSRRQKAVFSNNAFGFIDPYEGSADGETESVMSMSVTSAGGTSPIVSLREELRNDIEIVYFPQGSVLVEQGERHPGLYYVVDGFLDVGIPVNDKEEDLVGSSRPAQEEIFPMLRRTNTSSSRVSGSGAAANDPRRKKQSRKSLYLIKPGGIQGYVGAVASYRSYTDVVAKTDVYVGFLPRASLERIAERYPLALLTLAKRLTSLLPRLLLHIDFALEWVQVSAGQVIYHQGDESDAIYLALNGRLRSVLEGPDGKMTVVAEYGQGESVGELEVMTESTRPATLHAIRDTELAKFPRTLFNSLAQEHPGITIQVSKLIAQRMRDLVENPMTEKGIEPSGSGMVKTARSTLNLRTVGILPVTAGVPVVEFGNRLLQALHQIGVTNGATSLNQAAILNHLGRHAFSKMGKLKLSQYLADLEEKYGMVLYIADTTVNSPWTQTCITQADCILLVGLAESSPSIGEYERFLLGMKTTARKELVLLHGERYCPPGLTRQWLKNRVWINGGHHHIQMAFRLTAEPSHPQAKRFGTVLKQRVQVLQAEIQKYTSRRIRQSPLYSAQTPFKGDFHRLARRLCGRSVGLVLGGGGARGIAQVGVIKALEEAGIPIDIIGGTSIGSFIGALYARDADVVPMYGRAKKFAGRMGSIWRFALDLTYPTVSYTTGHEFNRGIFKTFGDSQIEDFWLEFYCNTTNISRSRAEYHSSGYTWRYVRASMSLAGLIPPICDEGSMLLDGGYIDNLTVDHMKGLGADVIFAVDVGSLDDNTPQGYGDSLSGIWAVVNRWNPFSSCPNPPTLSEIQARLAYVSSIENLERAKNTPGCLYMRPPIDRYGTLEFGKFDEIYQLGYAYGKEYLDKLKREGSLPLPEETEEKKKLQRTLAPRRASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6M5</accession>
    <name>A0A317X6M5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase II transcription factor SIII subunit A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_460744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470063.1">
        <property type="nucleotide sequence ID" value="XM_025607895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6M5"/>
    <dbReference type="STRING" id="1450535.A0A317X6M5"/>
    <dbReference type="GeneID" id="37110038"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39385" checksum="14E272BA1FD1B4F7" modified="2018-10-10" version="1">MPPPSLLQLCTAIAIRNVKHLDDIGNMPYTLARPFLLKVESPEKLRSLELNSPHIMRDDEELWLEFIKRDIPRWEEYDLPEKPDCWYDVYCDLREQVQRAVDEDAEKLKLALDGISSEREKHSAKLVTDRRIIGLPRERPTAKQRYASFDRRMGGIAPTKKKNSIFTATRRNTVLAVPTKHLNNRATQVRQAPRSLIEEHRRPAEPAVPRRQAPQALRAPGRSLSQVSIGSASQNNPTVNPTLREREARLRAITSGRSTNPQSHPPGASSRAVRNVPTSPPTSDPSESVSKGARSQPNMQASNSHDSSATNPQLKSGVADMPASPPQPPRPAAVRKRPAPSLFIQPKKKKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6S7</accession>
    <name>A0A317X6S7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_554066</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471034.1">
        <property type="nucleotide sequence ID" value="XM_025613695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6S7"/>
    <dbReference type="STRING" id="1450535.A0A317X6S7"/>
    <dbReference type="GeneID" id="37115838"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY94273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="549" mass="56947" checksum="78C833A2458D7377" modified="2018-10-10" version="1">MANPVDPALTSSVSASQPPAPEMQSPSVQQPPQGASPSKPAKQQPPKQPAKGKDGAAAAASAPSGDGAALTPAELKKKAKADKAARRARERAERETTGGGPAGGPGGQHAASAKKGASGPGGAGGKDSAAAAQQKGQKQLPRRGSAQATAQVGAAELKKKQEEKNVSVFGHLYGQQRRTTIAGAGKEVHPAVLALGLQMRDYVVCGSSARCVATLLAFKRVIEAYTTPLGTSLARHLTTHLSHQITYLSTCRPLSISQGNAIRALKLAISSIDPSVPEATAKSSLCDFIDSFIREKITVADQVIAGSAAQKIQDGDVIVTFAGSSIVKQTLLMAHKQGKQFRVSIIDSRPLFEGKNLARSLANAGLDVQYSLMNGISHAIKDATKVFLGAHAMTSNGRLYSRVGTALVAMSAKERAGGVEVPVIVCCETVKFTDRVALDSIVVNEIADADELVTIEPVQQLTGLPDPAAPAPAETKKGGKATASAPVESSTASQSTASPLEDWKESANLQLLNIMYDVTPAEYVDMVVTEMGSLPPSAVPIVHRMSTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6W1</accession>
    <name>A0A317X6W1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_532297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471125.1">
        <property type="nucleotide sequence ID" value="XM_025611095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6W1"/>
    <dbReference type="STRING" id="1450535.A0A317X6W1"/>
    <dbReference type="GeneID" id="37113238"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF668">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="53"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="457" mass="49340" checksum="ADF5485BBE35DE4C" modified="2018-10-10" version="1">MTTTPRDVEALAVHHEPGVLDDTLEKKVSANESPPADDPFGNEECGEVKYRVMKWWHCGILMIAENISLGILSLPSAVATLGIVPSIFLILGLSGISWYTGYVIGQFKLRYPQIHSMGDAGELLFGRIGREILFFGQLLFCIFLMSSHILTFTVLFNTITGHGTCTIVFGVVGLVVSFIGALPRTMGKVYIMSLVSCTSITIATIVTMVAIAVQAPDHVEVDITTHPSFANAFLAVTNIVFAFIAHVAFFGFISEMEDPRDFPKSLAMLQVMDTTMYIVTAMVIYRYAGPDVASPALSSAGPLMSKVAYGLAIPTVVIAGVVFGHVASKYIYVRLWRGSPQMHTNSLAAVGSWVAIALGVWVIAWVIAESIPVFNDLLSLISSLFGSWFSYGLPAMFWLVMNKGQYTASPSKIFLTIVNLVIFGIACAICGLGLYVSGKSIHDSSSSASWTCANNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6Z8</accession>
    <name>A0A317X6Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MOSC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_583555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470088.1">
        <property type="nucleotide sequence ID" value="XM_025615567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6Z8"/>
    <dbReference type="STRING" id="1450535.A0A317X6Z8"/>
    <dbReference type="GeneID" id="37117710"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF34">
        <property type="entry name" value="MOSC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G07820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="202"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="390" mass="43074" checksum="84B947B925E50F57" modified="2018-10-10" version="1">MQIGELYTYPIKSLQGITLSTAELTARGFPYDRRFMLLKVVYNDDGTSTKKNMHVPHFPEMSLFYTDLIYPSMDGAESGRIIVTYRPPDHAKSRTLEVPLQPDTRGLEELAIVMHQSPTKGYNMGERYNGWFSKCFGYEVVLAYLGPHSRGVLGSFAPEKSVAHMSLNNSWVSMKAVGGLTIATLLLNWVVGPGEISVREMLPSLAATVVAVLLLGWTRYGGGWARKGERITFADTAPYLLVSRTSVADVSARLTGDEEMDVTKFRPNIVVAGAQTAFEEDFWAELKVGQDQGAGEGLARLLLTANCVRCQSLNVDYATGKMGTGETGTVLKKLMKDRRVDKGARFSPVFGRYVFLDGKSDGQTVRVGDAVVVARRIEERMVYDWPGLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7Q8</accession>
    <name>A0A317X7Q8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_621108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471405.1">
        <property type="nucleotide sequence ID" value="XM_025616975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7Q8"/>
    <dbReference type="STRING" id="1450535.A0A317X7Q8"/>
    <dbReference type="GeneID" id="37119118"/>
    <dbReference type="OrthoDB" id="3898179at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="613" mass="65671" checksum="7B964F8CA1BCBC27" modified="2018-10-10" version="1">MGKPPAAIIIARHGARLDAADKNWHLTSPTPYDPPLSYGGWLQSRTLGTRIIDIIQSLGGSLDSTTQTEDGVKAPSDRLQKPKPKRRIIIHTSPFTRCLQTAIAVSSGICQNSGEPDFTPSKASTIVQSSSESSLTPGPISSNDHRCLLRVDAFLGEWLCPDYFDEIIPPPNSDRMITAAKLELLRREHSFVPPADTGPRPSTGFFPGGWGSASTPVSPAIEPTGAVKAGLPPVTRQTLGQRSRAGSCDALGSAENTRGRRTLSRINTNLPSIPDAAYVPPTPSYAISPSDPIPAGYVTHARDACVKIDFQWDSMHGEQNWGDGGDYGEEWSTMHTRFRTGLDRMISWYRDHDPSIPSGRPRRHSQTLDGSEEASPLNDAEEATETILVVITHGAGCNALIGALSGEPALVNIGTASLTLAVRNDRLPETAEGDSIGGPVRARGSADESSSLASYSMKLVASTEHLRATGSTSRVSSPSHVTSPSVSSYRRVANRPSLSQGLFIIGPSSTSGPTTEPWSAERPSTAVSSKSSGLWGSIAEPTDEIVPNFDWPTPSAPAVNGDSQASTLKADDSTWAKLPQRTLSQRGLWSSSPLSKERDLGHKRRWTVTERRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7U3</accession>
    <name>A0A317X7U3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_532631</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470463.1">
        <property type="nucleotide sequence ID" value="XM_025611160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7U3"/>
    <dbReference type="STRING" id="1450535.A0A317X7U3"/>
    <dbReference type="GeneID" id="37113303"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="16"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="202"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY93702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="404" mass="43506" checksum="64A1CA32CE38B820" modified="2018-10-10" version="1">MAAPADNQVFRATTTAPVNIAVIKYWGKRDTVLNLPTNSSLSVTLSQRSLRTLTTASCAPFYPAKDELTLNGNPQDIQSSKRTLACLASLRSLRRELEEADSSLPKLSTFPLRIVSENNFPTAAGLASSAAGFAALVRAVADLYKLPQSPRDLSRIARQGSGSACRSLMGGYVAWRAGSLEDGSDSLAEEVAPQAHWPEMRAVILVVSAEKKDVPSTEGMQTTVATSNLFATRANTVVPERMAAIETAIQNRDFPAFAEITMRDSNGFHATCLDSWPPIFYMNDVSRAAVRLVHDINRAVGRTVCAYTFDAGPNAVIYYLEKDTELVAGTIKAILGEKGEGWEGPFYEPLRNLTAPGVALDQVDPRTVESLKDGVSRVILTGVGEGPISVDEHLVSEKGDILSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8H9</accession>
    <name>A0A317X8H9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin cytoskeleton-regulatory complex protein END3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein end3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Cytoskeletal adapter protein sagA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">Endocytosis protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BO94DRAFT_531788</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the END3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471610.1">
        <property type="nucleotide sequence ID" value="XM_025610976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8H9"/>
    <dbReference type="STRING" id="1450535.A0A317X8H9"/>
    <dbReference type="GeneID" id="37113119"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000323">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein end3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000339">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein END3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025604">
        <property type="entry name" value="End3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12761">
        <property type="entry name" value="End3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="24">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="EH" evidence="23">
        <location>
            <begin position="139"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="22">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00032224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PWY94849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="404" mass="46106" checksum="90DB8A9D149B2BFA" modified="2018-10-10" version="1">MSTKKIEQWEIERYWEIFASLAGGQPRLNNSQAASVLRNSRLRDDQLEKVWDLADVDGDGELDFEEFCVAMRLVFDLVNGELQSVPNVLPDWLVPESKSHLVHATRALSSRPEQFERIEDEDDTPGLKDGFEWYMNPADKSKYEEIYIANKNHRGEISFESLQPLYDSLDVPDTDIRSAWNLANPSASPSINKDATLAFLHILNYRHEGFRIPRTIPASLRASFENNKIDYQIDNARPAQKWGANGDTETRTGRKAKFGDTYLSRLGAGGKTSYTPKGTDFSDTIQDEEWEKVRLRRELAELDSKLDSARKASEGRRDRPRNGGGPNWVLIKKEALQLLEYKERELRELREGAGRSKDGQNVERLRDDVKTVGEQVEGLKSHLAQRKGVLSDLRTQVEEAKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8M9</accession>
    <name>A0A317X8M9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL14m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_532992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470029.1">
        <property type="nucleotide sequence ID" value="XM_025611247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8M9"/>
    <dbReference type="STRING" id="1450535.A0A317X8M9"/>
    <dbReference type="GeneID" id="37113390"/>
    <dbReference type="OrthoDB" id="274765at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000005">
        <property type="entry name" value="50S ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_uL14_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="186" mass="20302" checksum="F4425AA09A3A4759" modified="2018-10-10" version="1">MRCEEGCRAPSGVGRRRNLPARDCCWAAFLSGDPITSSTSTPPSTPPLRQGIRSKMIQLKTMLNCIDNSGAAVVECVNVLKKQRPATVGDRIVVVVQKQRNFGPDSTNNVGIANKVRRGDIRHAVVVRARKEMQRPDGSIVKFDDNACVLVNKSGDPIGTRMNGVVATELRGRQWSKILSLAPMHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X945</accession>
    <name>A0A317X945_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_553580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471452.1">
        <property type="nucleotide sequence ID" value="XM_025613667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X945"/>
    <dbReference type="STRING" id="1450535.A0A317X945"/>
    <dbReference type="GeneID" id="37115810"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="222"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="256"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="293" mass="33152" checksum="D9C3ED8C8FC3532F" modified="2018-10-10" version="1">MDRTPTSFPSSPVAYSSPLHAVPFDRYDFQSLSGLGLSNCDTGSPSDQIRLYPCPEQYALSTSNWSDPITRSPNFLETPPDVSHFPHYEQFGSRADVSVSPSYSPVMDFRVMHEDISRFWPNTPPSETAMVSEGWTNVKEQPEEIWDASLVDGANNPTMSTMPQLPRLQINTTFIHPQRPDETQTELDASREVPAETISKWIEDVNGSPHGEQLKIPSASGLECTTCGLRFTRRSNCREHMKSHDPTYIHKGIRKYGCEKCGRRYSRQDTLSRHLLDGCDGRTRKSRAPRRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9L5</accession>
    <name>A0A317X9L5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_508429</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472037.1">
        <property type="nucleotide sequence ID" value="XM_025609662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9L5"/>
    <dbReference type="STRING" id="1450535.A0A317X9L5"/>
    <dbReference type="GeneID" id="37111805"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000008">
        <property type="entry name" value="Related to potassium channel regulatory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="10">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Prp18" evidence="9">
        <location>
            <begin position="211"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY95276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="361" mass="42227" checksum="EB92E12DBEE24EE5" modified="2018-10-10" version="1">MDFAALMSKEISKAKPKADAQDTAKPKYTRRGDLEAARIAAYNEEQERLSREREERLIQKRKLEDEEAERRQEREDKKRKLAEESRKKREEEEASRERERRKRLGLPELPPTEAGDDKDADKDGEEDIPEEELLQKLRELEEPAILFGETHKGRLRRYRRLVQRASTPQQQLSDGPIPTTLELVPEVEMKIPETVPKDLEGKKFLFRQLASYFNMVLREWELALAKRDVSVKQSLQGRQAYNAMVQSRENMKPLFRKFEKVEIDNGVLEHVVEIVSKAQQRRYVDANDAYLRLSIGKAAWPIGVTMVGIHERSAREKLHQSDQQAHILSDEITRKYLQSIKRCLSFAQTRWPPDDQLQIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAX4</accession>
    <name>A0A317XAX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470859.1">
        <property type="nucleotide sequence ID" value="XM_025611042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAX4"/>
    <dbReference type="GeneID" id="37113185"/>
    <dbReference type="OrthoDB" id="3798541at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016274772" evidence="1">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="240" mass="23706" checksum="BE34E72F0460B83B" modified="2018-10-10" version="1">MKASFITILATLATSAIAAPTGGLSGLTEVTKTVTSGSVVSSNVVSTPVASSGATGHIVQNAGSSVNQVLTVTGPNAKKLLIQLSPDVASLLSGLGLPSIKASVGSIVKSAASVGDLIKDLGPAVDGLLTVVGKDVGALLIQLDPEVAGLVTGLGLPGVGVPVGSVVGTLGENLKRSPDGKIVEDLSPKVKDVLEVTGTDSKRLLVQLSPSIASLVSNLGLPSVGTSVGQIIKTPYPAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB83</accession>
    <name>A0A317XB83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_531795</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471618.1">
        <property type="nucleotide sequence ID" value="XM_025610978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB83"/>
    <dbReference type="STRING" id="1450535.A0A317XB83"/>
    <dbReference type="GeneID" id="37113121"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="314" mass="36195" checksum="1B45BF6CCC05EC1A" modified="2018-10-10" version="1">MKPFSTPVLSKRTYRELKLLKHLRHENIISLSDIFISPLEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVVHRDLKPSNILINENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAACIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVIQTICSENTLRFVKSLPKRERQPLASKFKNADPDAVDLLERMLVFDPKKRIRAGEALAHEYLAPYHDPTDEPVAEEKFDWSFNDADLPVDTWKIMMYSEILDFHNIDQTNDAGQVLVEGAADGQQAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC32</accession>
    <name>A0A317XC32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_582504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470861.1">
        <property type="nucleotide sequence ID" value="XM_025615481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC32"/>
    <dbReference type="GeneID" id="37117624"/>
    <dbReference type="OrthoDB" id="5374206at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="195" mass="20921" checksum="A889DD1B621DEDF6" modified="2018-10-10" version="1">MTSSSSDDYPGDAAYAKISLVDENQRQLVDAHELMDQYTGLKQLFDFETRYHVGAYSVDSTLIVDIAKFVDACYLVSTNPTAAPHDALYLANATDIRGSRYEAKGSNIPPSGGKIWWSLLKDENVKSYVAQVSKAEQMNLQEAQTSDLGAGAEIALNVLMAASLVPYVGPFLSTVGSAEIEGLTNVKVDSSAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCE6</accession>
    <name>A0A317XCE6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Arsenite efflux transporter ArsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_455214</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472552.1">
        <property type="nucleotide sequence ID" value="XM_025607642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCE6"/>
    <dbReference type="STRING" id="1450535.A0A317XCE6"/>
    <dbReference type="GeneID" id="37109785"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY95791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="370" mass="40655" checksum="60E72B1428478E7A" modified="2018-10-10" version="1">MAHEKHQPEDVEACSESQHHDNSPTSAFQQLAILDRFLAVWIFLAMVVGIILGNFIPNTSKALDRGKFVGVSVPIAIGLLVMMYPILCKVRFETLHRSSREKDLWIQIGFSIVVNWIIAPLFMLGLAWAFLPDERGLREGLILVGIARCIAMVLVWTGLAGGDGEYCAILVAINSILQMVLFAPLAILFIRIIGGADHGLTIDYSLAAKSVGVFLGIPLGAAIVTRFCLRFLISREWYDKQFLKWISPLSLIGLLFTILVLFASQGRHVVHQIVSVIRVAAPLVVYFGVIFGVTLAVTRRFGFGYRLSCTQSFTAASNNFELAIAVAIATFGVDSDQALAATVGPLIEVPVLLGLVYVVKWFAKRKKWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCK0</accession>
    <name>A0A317XCK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Formyltetrahydrofolate deformylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_484283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472193.1">
        <property type="nucleotide sequence ID" value="XM_025608952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCK0"/>
    <dbReference type="STRING" id="1450535.A0A317XCK0"/>
    <dbReference type="GeneID" id="37111095"/>
    <dbReference type="OrthoDB" id="4239773at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008864">
        <property type="term" value="F:formyltetrahydrofolate deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04875">
        <property type="entry name" value="ACT_F4HF-DF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08648">
        <property type="entry name" value="FMT_core_Formyl-FH4-Hydrolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.170">
        <property type="entry name" value="Formyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01927">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041729">
        <property type="entry name" value="Formyl-FH4-Hydrolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004810">
        <property type="entry name" value="PurU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044074">
        <property type="entry name" value="PurU_ACT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004684">
        <property type="entry name" value="PRK06027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00655">
        <property type="entry name" value="PurU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42706:SF1">
        <property type="entry name" value="FORMYLTETRAHYDROFOLATE DEFORMYLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036480">
        <property type="entry name" value="FormyFH4_hydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01575">
        <property type="entry name" value="FFH4HYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="283" mass="31330" checksum="68D0C0E4BFB20776" modified="2018-10-10" version="1">MSYILTLSCPDRPGIVHAVTAYLVQQNLNIIDSSQYGDPTSERFFMRVHFKDESNPGQSLTELRSAFEPTATSLSMDFQLVTASTKPRVLIMVSKIGHCLNDLLFRASTGQLAIEIPLIVSNHPDFATLAATYNIPFLHLPVTAATKPQQEGRILELIREHNIDLVVLARYMQVLSPTLCEAMSGKIINIHHSFLPSFKGAKPYHQAFDRGVKIVGATAHFVTSDLDEGPIIEQNVVRVNHAMSPKELTHAGSNVESNVLATAVKYFAERRVLLNGHKTVVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCR9</accession>
    <name>A0A317XCR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_530661</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472682.1">
        <property type="nucleotide sequence ID" value="XM_025610721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCR9"/>
    <dbReference type="STRING" id="1450535.A0A317XCR9"/>
    <dbReference type="GeneID" id="37112864"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000011">
        <property type="entry name" value="Cyanide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="329" mass="36008" checksum="FE4CB2634AE3826B" modified="2018-10-10" version="1">MQEPTSSQIRVAVTQAEPVWLDLNATVDKTCSLIAEAAANGAQLITFPECWIPGYPAWIWSRPVDMRLSSIYIQNSLKVDSPQMSRIQQCAAENKIVVVLGYSENIHNSLYIGQAIIGSDGKILTTRKKIKATHMERTIFGDSPGDCLHSVVDTSAGRVGALSCWEHIQPLLKYHTYSQREQIHVAAWPPLFPDNDDGNLFSISSEGTSAIARTYAIESQSFVLHTTTVISQAGIDRMDTQAKALMSTPGGGCSAIFGPDGRQLSQPMPSTEEGIIYANLDLDLIYHSKSFVDVCGHYSRPDLLWLGVESGVRTHVRDQAGVAAQEQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDJ7</accession>
    <name>A0A317XDJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="4 12">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_529787</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="12">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="4 12"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473166.1">
        <property type="nucleotide sequence ID" value="XM_025610529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDJ7"/>
    <dbReference type="STRING" id="1450535.A0A317XDJ7"/>
    <dbReference type="GeneID" id="37112672"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="11 12" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="14">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY96405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="154" mass="15916" checksum="DBB3354D66C4CA4C" modified="2018-10-10" version="1">MVKAVAVIRGDSKISGTVTFEQADENTPTTISWNITGHDANAERGFHVHQFGDNTNGCTSAGPHFNPFGKTHGAPEDADRHVGDLGNFKTDAEGNAVGSKQDKLVKLIGAESVLGRTLVVHAGTDDLGRGGNEESKKTGNAGPRPACGVIGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEQ7</accession>
    <name>A0A317XEQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_480996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473053.1">
        <property type="nucleotide sequence ID" value="XM_025608843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEQ7"/>
    <dbReference type="GeneID" id="37110986"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40257:SF1">
        <property type="entry name" value="DUF1330 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="269" mass="30034" checksum="7BDCB23EBD4797C9" modified="2018-10-10" version="1">MPVASLYLLSLTTDTSSFLNSLRSTRKVIVSSRPRHAVIRPTVLDKDILTRTPWDLLVLIQPPPDSPPIPLTLQSQIKTQYYVTVGVPSKLLSTYASRDESLKRTAPSIPLTGSLDQARSKPSSQNLELSPELISFMDELTPQHSGPVTMLNLLHFNQPDGKKSYYQYGQAFIPVAGKRGGDAKLVGNVVKPKTADNATVDSRGDWAKREEDWWNEISIVHYPSIRHFCDMLAGEDYQGINEKYRLSALKDTFLLCTTEFDVESSPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF43</accession>
    <name>A0A317XF43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_8957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473173.1">
        <property type="nucleotide sequence ID" value="XM_025617729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF43"/>
    <dbReference type="STRING" id="1450535.A0A317XF43"/>
    <dbReference type="GeneID" id="37119872"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000100">
        <property type="entry name" value="Zinc finger 45-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="227"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY96412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="844" mass="95404" checksum="3E429E2F3AD445A3" modified="2018-10-10" version="1">MLPQPSSQPARGSRRSNAGAKTRVCVHCGRSFRRTEHLERHVRTHTKEKPYICFCGSAFTRRDLLKRHTTIAHQSSGLVSPNSQPDNEALDHANRPRASEPATVQPHYNNQPTSRPDVSLSVPPNVEQWTGPQRGPYIEQDRNHVLDTGGSSTGGLGAHNSAVGHDAEILEAAQLLLPGNYRHAQAAPAQPMPYLHEELNHFQDFTHFLDSIGLPSEWVPAFGDIPQIHNPVSTEPPEFSRNAGEQHESSSRPRQTDRSRADSPFRSWLPSVPPGDQSFASVSDYEPPQLAKSQSPLKVTEEHRQRLAASLDEFRYLIPDFVLPSRHTLTRYLTSYFSGFHTHLPFIHVPTLRINERAPELILAFMTIGAQYRFEHRNAERLFYAAKAIVLYRLSKESSPPPYNAIIQIPLNSIRDSSQRSNQDPSLSPSEFAAGMDAWRRIENIRTLLVLMGYSTWEKAELVQEAFGLQTLLVRCLREFGLLENITVAPRHAPLQWHEWAEEESIRRTRFISFCFVHVHSISYNIYPVLRSSEVHLRLPCSTKEWKAATAHDWEIAQKEVGSQQLFFQDALALLLQPSRAPVLLDPIPAPLGNYILLHGLLQRIHLVSELSIPNGDQSFSLPTEELNKLERALRSWTSVWQQAPESSLDPHNENGPIPFTSSSLLGLAYVRLSLNLGPHRQLETRDPYRIATAMHRSPRPGRSYRLTPALIYSAHALSIPVRLGIDHVARSQAFFWSVRHSLASLECAVLLSKWLMSLAETGSNQALSENESRILHWTRCIVQEAYESMDLDEGEAFPSQDPSSLGLAVIKLWARLFRKNTQWPFINVLGESLERYLALIRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFI4</accession>
    <name>A0A317XFI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_14484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473318.1">
        <property type="nucleotide sequence ID" value="XM_025605752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFI4"/>
    <dbReference type="STRING" id="1450535.A0A317XFI4"/>
    <dbReference type="GeneID" id="37107895"/>
    <dbReference type="OrthoDB" id="3798541at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016319478" evidence="2">
        <location>
            <begin position="18"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="520" mass="50531" checksum="454BF5960CC907D5" modified="2018-10-10" version="1">MKASFVTALALAACTLASPVGQPHARGNECTCGGSGPSSGTEPTQPAPESSASPSGPSGVSTYPGTSSQAPTLPGYQPAPTVTVTTTVPYKPVPESSSSSQAPAPTAPASESPAPETSEPCTTPATSEPAGQSSGQPTGPAGPTGPASQPSASSSSAPVSGPTGEPSGSSGYPSGSTGPASQPAPSSSSAPASQPSGPTGPTGPAGSPSSSSPAGQPTQPSGPSSPAGPSGTGSSGNPGGSKPSSTSSTPSSSTPASTPSSTPSCENGHCHGTGHLIQDLGPQADHLLTVIGNGTEQLLIELSDPVADLLSSLGLTGLAEPVGHIIKDASTIGELITDLGAPVDHLLIAVGKDTGYLLIELDHDVKDLLNSIGLNSLADPVGDLLGAIGSSLKRREDASNPNGLLEKLGPVVDCILRVTGEDTKDLLIKLSDPVAELFKSLGLTGVGRSVGEVIKSAASVGDLIADLGPVADCLLTVIGDDGSALLIKLAPDVADLVSSLGLPGVGQAVGEVLYVVGENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFX5</accession>
    <name>A0A317XFX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_18557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473508.1">
        <property type="nucleotide sequence ID" value="XM_025606006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFX5"/>
    <dbReference type="STRING" id="1450535.A0A317XFX5"/>
    <dbReference type="GeneID" id="37108149"/>
    <dbReference type="OrthoDB" id="2580841at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019268">
        <property type="entry name" value="DUF2278"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10042">
        <property type="entry name" value="DUF2278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="225" mass="25284" checksum="9D8D4A14D5AE0C41" modified="2018-10-10" version="1">MTIPHYGVWIAQPTRYTAQTEQEDPKSPHIYLYFKDDSSSRRNLEAAINVKSTGQDSRLVYWFDQSFTHPITEKLTNLNEGFHLLKSYAHRRYRRQESDLSGLDFIRTQGLVDIEAGTVLSEADTGPNNAVLQKLEPILNEAISREATVYIFGSSYGSGIHDIHMNQGSSPSYENGIYEDGALLFRFDDGHWEAVFLAFASQEIPTNDKGEAEEGSKSLASILGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGH2</accession>
    <name>A0A317XGH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_530723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472761.1">
        <property type="nucleotide sequence ID" value="XM_025610732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGH2"/>
    <dbReference type="GeneID" id="37112875"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="265" mass="28351" checksum="DCD3816A3460FC55" modified="2018-10-10" version="1">MSKIVLITGSNTGIGLEVVKALVGASKPYTILMAGRTPQKVHDAISTTQKTFPSTPSTFVPLQVDLESDNSIEQAFTEVNSKFGKLDVLINNGGATFDHEVLSGKLSARDMWNKTWNVNTAGTHILTSTFAPLLLRSSDPRLLFLTSGTSTLAGTDNLATPVNQVPPKGWPKTGFNVPAYRSSKTGLNMLMREWHRWLKEDGAKVFAISPGYLATGLGGDPEASKKHGAQDLVTSGVGAFIRGVIEGERDADAGKVINKNGVQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGT0</accession>
    <name>A0A317XGT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_561754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472961.1">
        <property type="nucleotide sequence ID" value="XM_025614241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGT0"/>
    <dbReference type="GeneID" id="37116384"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY96200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="512" mass="57566" checksum="79BB87750C7C0C3F" modified="2018-10-10" version="1">MEKPQGQLLCIMMTVTCGISYLLYGYDQGFMSGVLLSQDFLIIMEDPSTFIQGLLSSLYTLGCFFGCVSSISFSEKLGRKKPILIGTLLISVGAVIQTAAYSPAQFIVGRPVAGTGTGLNTSIIPVWQAETLPAKKRERFGAIQYVLVCTGTTISYWMASARSFSANSVFQWCFLVRAQLVFAAMIVCLVPWMPESPRWDFVHGHREKGLRTLMRMHGTSDEHQCEVEAEARLIQQAVEFEAIHKATRWVDLFKNESRTQNLRRLMLGWWLMFMVMWSGVCSIGYYISYLFEVSVGLSHNLSLLLSGFNGLWYLLSAFVPFFVINHLGKRRCMMISAAGMGCCFLTMALAIRSGTFAASIICIIAFFLYYTFFALGYLAIPWLYNAEIMPLHLRSQGTAITTSSNWIWNFATVMMTPSLMSQQGWKGYLVFTVFNFCFVPAIYLFYPETTGRRLEEIDAIFYGTSVLVARTEWAEKGRFDVSPLGVTQGLEPSQKEMVGPHVEYVNSVSEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XH83</accession>
    <name>A0A317XH83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_454319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473231.1">
        <property type="nucleotide sequence ID" value="XM_025607605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XH83"/>
    <dbReference type="STRING" id="1450535.A0A317XH83"/>
    <dbReference type="GeneID" id="37109748"/>
    <dbReference type="OrthoDB" id="1922977at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="198"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="865"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="783"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="673"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="922"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1042"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1055"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1101" mass="117930" checksum="3A0CD8BC75C04F1E" modified="2018-10-10" version="1">MPSLYPHNLGFSQNPSPVPQHPQDGLSHPFDYNTDNFNGNSHLPGLGGPGAVGPLPPPPFAFMGPFASTQFPPPPFPPLQMPPLRYPSIPVPSAPIYDPTRPAVGDYQMDHSAPTPPVPQLATAGNSESDPDREEGELTDREAPSTSQPRQRGPGTQIHRVINGDSGSIRRGQAMKSNGRGSYGSDVSHLSAMAISEGSAQGNPDLEKGEVSPESRPSSRSSGSPYNPAPPSSTEPPVGSIRPEAPALSKPQHEAIPENGTNNAASCESQSLPSGGRSPAQLRVQAQGALLSLAPHNIRYGEFVGEGINPVILRQLYEEVGIKITTPQPELSVASPPSDMSVGSEHSTTSQSGEPEPVNRPLGNSSADGSSAQQSTPTEIVTAVSPSLPSDTAKPMERKEVIARMLAAKAAKNSGASVQVQAEETNEASVPDGSGLPDADNMSVITSQDGQAKEKEVRVKEKNKAQTELARQRIELLKKQGLVRNGQKPQSESVPPEKGQPPNAPAQDVAATSTPIPIQHPLPERPPDPESNAPARIPGLFMTEEPNDENTPASTTQSLADTTPQARVNQRKRPRASDFDEPVPIPKKSFNNGVNHAIPDTQRLIIDISDDEFYGDDESDSMDVDSPAGKDSQDADSLLQTFTTSVDAMPLRPATASSQGFSTSATPQSLRNNDQEHQEHLRRKDLEIKAMHKRIAELEERKKAKLAASRTQSPRASDVLGPSPPANIVLADDVSHASRPSTDAEDGNNPTSTKNILSVSVDIAHMERMRDKLLRKQEIEVGIPALENEIHKSEARLAEVKHEEDQLLLEITKGREGRQQLLDELMNINLELNGLTFEDVDAAMQRSQTEEQPCEVEDPVLQETIENGDMTPENAHPPQSVQEEREEESTRVSVQGAQAVLPVSASGSSIVSNDKLMHDVSDSSGEVSSSDSTGSAMDESSDSSSEESDQDEHQAHNPVPKTTDEPAEPEPQKSVEAGAGLHHNLPERPLPMDVEPQVELAIDEQATENQDQASRESSVSDGYEPPEPEVTASPAESSYSPPFSPASPGPVEPIETSTTDSMKQANEPLTETVQALDTQQPSTSTQVGILDVRCTSIQPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XHG1</accession>
    <name>A0A317XHG1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_15814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473361.1">
        <property type="nucleotide sequence ID" value="XM_025605851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XHG1"/>
    <dbReference type="STRING" id="1450535.A0A317XHG1"/>
    <dbReference type="GeneID" id="37107994"/>
    <dbReference type="OrthoDB" id="4152802at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="594"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="805" mass="90489" checksum="2586639AA545C286" modified="2018-10-10" version="1">MAIWPFGRKNKRHTIQLDAPAVADIQSSQEPRHSFDDSKLSRKLSRKHSKRQKNRHAQPVEVIPSSLRDVSHPTSSRVAQYLPPTSHSEQPTPMKENRLPVSRAGQHSDAYTTYSNMSHDQPSLSRSASLLRSKRNDTGPAVLKKKLSKRKAYEIAREREIRMLASSPIDIPRRPSPLPAEQFSIETRRGARAQSRRSDRHCSDGSLSMRDSAASSLSDIFESYTFKVNTFAAWTPRPVIRYVEAPRVSTAKSQRPPEASFRRDKTPTFATHDENIHSKKRVDRLADDLDAGALRELLERDRRRRERKQLEDQEKLHRKLQQAAEQQRQTEADAEAGVDTVPQNLPGETEEQSVAQRGRPGAESCATSDRLDEHTPRTNETNAFLGGESSGSWLREASKDTERGGRQSMESVHVLGNIDDSSIREPKLVMRRSFAPSQDMGMSGSSLSHSPSRRELYSPTSSQLYGIGRESTSDVSRTIDSDRRLSDHSSGRVNTITSIFRRGSSRLKRSYRERFHERSPEHSNPSHESFFKVQTQSSGPPPSFVTPRTFLGSGTIKRSQSKFTEHFGDEPLSPPDSRLQSPDIPEVVDEFERENEMSDINMGTQYPIPSSGSEAQDIPKNRHHSWTGDSWEGDPDNLPLSQSLASVDSEGSWMSGQFLRRISQKKASNPLRTSLNSSRNIVEEGRESSSKGDENPTSEPLVRFGTHQDDSPKAGTDITGPQPDKDTNMDRVPEQTEEAWHDHIARRPVLVTPAIRPKSNEGLLRNVQSFCADEEFSPIEEHSAEFEFETHDDTKAGSRTESGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UU65</accession>
    <name>A0A317UU65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_591461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000064">
        <property type="protein sequence ID" value="PWY65011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461362.1">
        <property type="nucleotide sequence ID" value="XM_025616108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UU65"/>
    <dbReference type="STRING" id="1450535.A0A317UU65"/>
    <dbReference type="GeneID" id="37118251"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="6">
        <location>
            <begin position="261"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY65011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="424" mass="47298" checksum="DCDF88C0060DBD3F" modified="2018-10-10" version="1">MLILPFLVVALFLQVKFPLLPGLRDFLYGLILLSACSAIFYPPESGNFITYANAFLSTSLIIRAVELLLVRNLSHVKRLQKVSYLSSSPLYAWEPISPTLGLKRFLQVCDLVINPRAIGWSYGSPKYQPPLQKMDAPDGTNGCIPECQNIGLVAEGDRFSFLTGKLCRVAVAYVLIDSYQAAIGRNYAGVCEGIEAFLTGVLGIQASPATSEMLMQLCILPTFCWMISYAFVDGIHAAGGIFSVGILRVISPQIAGDPWMYPPVFGAMQYLFTFSLRDIWGKMWHDLCRRPFLALSLALIPDSCPTGLKRFLVICVSFAVSGIVHSAGTYSVSKDWFAVGVMMVFFCSLPFFLAMQQIISEQILPRTFPRNSSISRVAIWLFNATFLMVWGHYTSPWYLRYSELPEAMASIPLPFSLWRTLFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UUG8</accession>
    <name>A0A317UUG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_629214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000056">
        <property type="protein sequence ID" value="PWY65683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461510.1">
        <property type="nucleotide sequence ID" value="XM_025617540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UUG8"/>
    <dbReference type="STRING" id="1450535.A0A317UUG8"/>
    <dbReference type="GeneID" id="37119683"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY65683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="371" mass="41489" checksum="6C9003C6FEE7E023" modified="2018-10-10" version="1">MIIPSAIYKPPDNPPFNILTITTHSPFHYHHHAPFQNPHSAPQPLSPNGPHLPRIGIGTMSLGGAYKQQNTLSEKLAFLTHAHSIGQTFWDTADIYFSSEAVIGEWFKQTGKREDIFLATKFGLSFENMKQEIRSDPEYVRFACERSLGVLGTDWIDLFYCHRVDGKTPVERTVEAMVELKREGKIKYLGLSEVSATTLRRAHAVHPITAVQMEYSPFCLDIEYPQSDLLRTCRELGVAVVAYSPIGRGLLTGQFTSSTELGDDDFRRIIPRYSSGLDKILAIVQRFKAIGEKHECTPAQVALGWLLAQGPDIFPIPGTRSVKYLEENAAAVDVVLSEEEVVEIRELVDMAGFEGERYPDGMTILPDTPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWI5</accession>
    <name>A0A317UWI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nonribosomal peptide synthetase sidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Siderophore peptide synthetase C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_504387</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461658.1">
        <property type="nucleotide sequence ID" value="XM_025609508.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317UWI5"/>
    <dbReference type="GeneID" id="37111651"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000055">
        <property type="entry name" value="Nonribosomal peptide synthetase sidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000038">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000014">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000015">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000056">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF2">
        <property type="entry name" value="FERRICROCIN SYNTHETASE (NONRIBOSOMAL PEPTIDE SIDEROPHORE SYNTHASE ) (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="848"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="1970"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3088"/>
            <end position="3164"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="3637"/>
            <end position="3710"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="4196"/>
            <end position="4269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY66394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="4749" mass="519473" checksum="62BC7BC6F0482222" modified="2018-10-10" version="1">[encoded data, 4749 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZL6</accession>
    <name>A0A317UZL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sterigmatocystin biosynthesis dehydrogenase stcV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_503825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461869.1">
        <property type="nucleotide sequence ID" value="XM_025609492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZL6"/>
    <dbReference type="STRING" id="1450535.A0A317UZL6"/>
    <dbReference type="GeneID" id="37111635"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY67225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="383" mass="42754" checksum="5EF3BB0E6CD2C42C" modified="2018-10-10" version="1">MSDFFTPPKPKSLLGFHQVLSPTGGIKVSPLCLGSMNFGTAWESYMGECSKENSFAIMDTFFENGGNFIDSANAYHDGQSEQWIGEWMKQRGNRDQMVIATKYTTGCRRAHAATEPIQSNFVGNSIKSMHLSVKQSLENLQTDYIDILYVHWWDFTTSVAEVMHGLNALVLAGKVLYLGISDTPAWVVVKANEYARSNGLRTFSVYQGRWSAAVRDVESEIVPMCRDQGLAIAPFASLGQGRFRSAEQRQEEYKGSARGAVQTEADIKISDALEEIAKRRGTTIHAIALAWIRFKTPYVFPIIGQRKVEHLKANIEALKIDLSKEEMDEIDNATAFDPGFPMNFILGDRFSTSFTAADVSATRWTAYIDAPTPAMPVRPRKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0A8</accession>
    <name>A0A317V0A8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_480041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000057">
        <property type="protein sequence ID" value="PWY65620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461456.1">
        <property type="nucleotide sequence ID" value="XM_025608774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0A8"/>
    <dbReference type="STRING" id="1450535.A0A317V0A8"/>
    <dbReference type="GeneID" id="37110917"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016456560" evidence="2">
        <location>
            <begin position="18"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY65620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="351" mass="39429" checksum="597EDB07CDEADEE8" modified="2018-10-10" version="1">MHLFYYLLLLFLGLAHAHQNWGPSKFTTLVTFGDSYTDDTRVSYFYNHNGSAPPVGWVEPITNDSSTGGYIWGHYVHQYAPLTHRYNYAVSGASCSNAITPRTTSFGLYPSVLEYQVPAFTADSLYTPPNSTEPFLSLPVNETIYAIWIGTNDLGNYAFLTDSQVPGKTIPDYIDCVYDALEGVYATGKAKYFVIMNVVPLELAPLYATPENGGIGKNMYWPDKAGNFTEISGRMGGQVELVNEVYKWRTEGEWGVGKRYRGSKVAVMDVHGLVLDIYNNPTRYLNGSAPANVTGYNHHCDLTGTECYRLPSPDSFLWYDQLHPSERTDQVIAEEFVKVVRGESRWARYWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2Z4</accession>
    <name>A0A317V2Z4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_438817</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY68009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462058.1">
        <property type="nucleotide sequence ID" value="XM_025607499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2Z4"/>
    <dbReference type="STRING" id="1450535.A0A317V2Z4"/>
    <dbReference type="GeneID" id="37109642"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="337"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY68009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="475" mass="52104" checksum="62E1385142F5B000" modified="2018-10-10" version="1" fragment="single">MKIVIVGGGISGCVAYLALRKHLPRPPPPAEDHEFTIYEAYDANTNHDRSEQDTHSSTPIIGGGLGIAPNGLHVLERLDSDLLHEIVQGGYMVDHSNVKTKHGHLLMRLSSSTACLSPNNPLPMHLLGTSRHNLWQALHRRIPEDIIINKRVVKVTPNTTGPKTLTFADDSPPVSADVVIGADGLKSITKRALFPEATEDPYSPHYENLISIGGFLPTTSLPPTPPGSMNLLFSATGFFGYFYANSSPTSPHRSSPHHISPPGDTLAWWTTYSMPTPTPTPTPPDLTSPNLNLTTLTQHLHTRYSTWTDPTISTILPTITIKTIYPVFTSPPLPTFSSTGIILIGDAAHTLPPTSGQGASQALEDVEVLSLFLKHYLGISYHDENGGVSELEAVSRAGEEYTSLRRPRVQGILERAEKMQGLKRDSIGWLGGRVREWMMYLGMWLMGWFPGLVGWGMGLRGVVEYDLPWEVERVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V362</accession>
    <name>A0A317V362_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_570053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461886.1">
        <property type="nucleotide sequence ID" value="XM_025614774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V362"/>
    <dbReference type="GeneID" id="37116917"/>
    <dbReference type="OrthoDB" id="160054at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35396">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35396:SF1">
        <property type="entry name" value="SMALL SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016268661" evidence="1">
        <location>
            <begin position="19"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="147" mass="15262" checksum="A2E5D994141CF913" modified="2018-10-10" version="1">MLAKSLLTIVLGAVLATATVNPATTNTKGKCPGTYNCSAAKTSTAIQAAECSHNTRTSGTQTFAVFKTDHQYDSSYGAPYGTCAAYTCTAPTDSEMTDDDDDCWTFFWNDNGESSGSGTGCIRSPDDGTCGCEDSDGTFVYGGSNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V419</accession>
    <name>A0A317V419_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_551216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461936.1">
        <property type="nucleotide sequence ID" value="XM_025613534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V419"/>
    <dbReference type="GeneID" id="37115677"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="138" mass="14635" checksum="0F8C4CDCB5DDD3E4" modified="2018-10-10" version="1">MAITIMGPRLGGDLSTYLACVLITTYGLVASEIGSHWRCPGGPILFIARPPPAILQSGQWSSNHPIDPPEDSDSTVPGATRHRRHTLGPCNHASVIKQLAPSSFGLTPSRMVVVTPAAVTPRDKVNLSTDSNQRGRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4R6</accession>
    <name>A0A317V4R6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_540126</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462281.1">
        <property type="nucleotide sequence ID" value="XM_025612843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4R6"/>
    <dbReference type="GeneID" id="37114986"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="334"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY68966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="816" mass="92357" checksum="4EC8DFAEED4EF45B" modified="2018-10-10" version="1">MTDSPKGPVSLSSHSDKEKAAATETGIEETDLQSLLNQLRHIVAENELDVNFPVHILSQAREILDAETQHIDLSQLHEVIAEIGKHRDLIENDSPYPEVRAVVDPTDDPEVSANTFRAWFLGMIATILFTGVNQLFTLRYPTITIYSIVAQLLAYPCGVFMEKTLPTRQWNLFGWKFSLNPGPFNQKEHMLITVMSNVSFGGTNGTAYVTYIFQVLKAKSFYNLTSLYDKPGFQILVTLSTQLLGYGCAGVVRRFLVYPPSMIYPKCLSTIALNKALHSDEGRERVNGWKISRYRFFMYCFGGMFVYYWFPGYIFQALSYFNWINWIAPENVKLAIICGGINGLGLNPLPTFDWNIVYALYDPIIYPFYALANIGIGTILTAFCVIAPIYFSNVWKTAYFPIISNDVYDDTGSTYNVTRVLNTKGEFDLAGYEGYSQPYLTAGYSVMFFFFFAMYLATIVHVALYNRREITKGFSALWKWTNAREEHEDVHNRLMKRYKEVPEWWYLVILAVSFVFGCIGVAKYDTGMPIWGIVFAIILCLALQIPYGMVYAITNSEVTNNVIAEFIGGYAIPGKPVANLLFKAFGYIACAQSIQFVADLKLGHYMKIAPRVMFSAQLVATIVGAFVSLGVNVWALDNISDVCSLDQAQKFTCAGARDFYTSSVIWGAIGPRRLFGTGQIYNPLLYGFLVGALLPIPFYFFTKWWPRSGWRYVYIPLAFYGAADIAPYNVTYAWTPMVVGFVFNFWIKRRWQAWWEKYAYVFTSAMSCGVAISAIIIFFAVEYHAVNINWWGNEVSYVGCDNDACTLLSIPEGGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8J7</accession>
    <name>A0A317V8J7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Morphogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_550691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462676.1">
        <property type="nucleotide sequence ID" value="XM_025613505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8J7"/>
    <dbReference type="STRING" id="1450535.A0A317V8J7"/>
    <dbReference type="GeneID" id="37115648"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04401">
        <property type="entry name" value="RhoGAP_fMSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="43"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1007"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1028"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY70385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1053" mass="114504" checksum="D2383EE34123E21E" modified="2018-10-10" version="1">MPFFTRVFRSKDTNVSKKATKSPEVENKGPAKPTWTDAWQRTEVAPEEVQQLLRGCTQELKARGQALRIPQIADPCLVAPLTALQTPFLLLPFRPSTDASAARTFIRNYFTQSLERGSPLSGDALAQELRLSDPMVLCSVLKWCWSRLPGGVVTWEAYELFKVGEQDSQFARDAFSTFIPISVDSDARSKIIFDFFDLLAAVAAHGKSNGLGGRKLSRYAGWWAFDHTDTGNGFEAAYKNWASAADATSHLFFAYLRSLSPDLRGMNTISTLPIALQTLVQATEYPPETPTLLQVSTTKVVMIVDTVSPTPFALLRRAKNFEYRDSDRHLQEFASFEEPTKALTDECLRVLKCISSINQQAAPEPGTSTREASWSRFEDFGFGGAIESDLDDDSNAARLARNEFGGGLRSAPQSGAGDLGRPTTPSWADFMSSGFSDENVLKGSVPPLLLPPDKVLPPIATVRGQSSQSHKRSLNDEPSAGPGELASITTLDLDDSFWWVWISSLAGEEPTSRKAVFGRCALVETIIKDTKWLVLEEQVKGAAPEPEPGAYIVEKKRFFGFSTRKRGVGRRKSSAKKVSAVEDSYKRPDNQAPQSKTSIAPDQHARIQAAAAALQKRHREEQEAANGSKNVPEDVRNNTKTNSVMTLQPAILNEASQAMKWATNYDKNTYRSAYLSNSRAGTGAAAEEAKEAIDQPSTPTSPTASTSARQAPPPLPKDTPTGSPKPAVPSKNSPAHSRNGSASLAADLSTTESLPKQSMDSEESGRKIKKKPGNAGFKSMFGTVKKKNDSEAKPPMKPTGAGSAVAAARAALEDKARAAQEQSIRPGTNGKSTLKKKPVPVYVPVEAAKPVESTKPMETVQPAEAKPAEIKPAVTINPSEPTAEEKESESAEPKAPSEATKLTVTQSDEPQIRRQAEYDALSRIDTRERAAADQEFSRFDQGPLVEQPAFVPEDSPVSERFPEKPASFHSANDQVPVEAEEEPTLSVQPASTSYDRWAQIRQNAAARAAQLEARADQSDDDNTSEEESFESRAARIKARVAELTGNMQAASQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8Y5</accession>
    <name>A0A317V8Y5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_526617</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462728.1">
        <property type="nucleotide sequence ID" value="XM_025610356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8Y5"/>
    <dbReference type="STRING" id="1450535.A0A317V8Y5"/>
    <dbReference type="GeneID" id="37112499"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF532">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY70834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="504" mass="55134" checksum="B683776A66F5EF38" modified="2018-10-10" version="1">MTHERQPLLGATSDAPVHQRKHLTWMSAYILVVSRVIGSGIFATPGTIVKSAGSVGLSLSIWVVGTILAACSLAVSMEYGCMLPRSGGEKVYLEYTYPRPRFLASTMVAVQAVVLGFTASNCIVFAKYTFFAFNVVPTEFQHKVLAVGLMTAVTIVHGCFLRTGIWIQNALGWVKIFLIGVISLTGIWVILLHPYGSDAPATSVFSWDTLWEDSNWSWNLLSTSLLKVFYSYAGLNNVNNVLSEVDNPVRTVLTVCPAALLTAGALYFLANISYFLIVPLEDIKNSGELVAGLLFERLFGNVGRTLFPLAIAISAAGNVMVVTYALARVNQEIARQGFLPWSRLLSSSKPFGAPLGGLIVHYIPSLLVIALPPQGDVYNFILDVEGYPGQVFSLAVAGGLLLLRYREPSLPRPFKAWLPAVWLRVVICVTLLAAPFFPPADGKSDVNFFYATYAIVGMGVIVFGVLYWYVWTVLLPRWGGYQLEEEEEVLDDGTPITKLVRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9P3</accession>
    <name>A0A317V9P3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_560384</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462799.1">
        <property type="nucleotide sequence ID" value="XM_025614148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9P3"/>
    <dbReference type="STRING" id="1450535.A0A317V9P3"/>
    <dbReference type="GeneID" id="37116291"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="114"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY71044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="227" mass="24895" checksum="507DA543A16086A7" modified="2018-10-10" version="1">MEPANENTGSVPRQQPRPSSPSQPSTPPSDTISNATIAASLSNGVAVSNGPVLPRAEDLSNKDRPVSGIVPPYWSHHRNASRASHISIDQSPGITLEDHTEDPDCETSRGLWAKSVAVDDHVVVRGKTGIGSYVVWNCRIQTLDGGPITVRLRYSEFDDLRQRLVASFPHAKNALPPLPPKSVIFKFRPSFLESRRVGLEYFLNCVLLNPEFSSSPIVKDFLFGRLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VA09</accession>
    <name>A0A317VA09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_539591</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462811.1">
        <property type="nucleotide sequence ID" value="XM_025612730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VA09"/>
    <dbReference type="STRING" id="1450535.A0A317VA09"/>
    <dbReference type="GeneID" id="37114873"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY71056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="159" mass="17460" checksum="EDBB39F6B8ED497A" modified="2018-10-10" version="1">MSKTSQLSTPCLISLAFTTLFLITITILSFTPPDILPRILPPICPAQPPDQAQQTHGRIFTERPELERINADSDSDEVQTWESLLIPPSGGGIHSHTVPDSIHLNHSREGKILSWGISMFHQLHCLVALRALVFPETSESKINSTSGAHTGNMAHDRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VAS1</accession>
    <name>A0A317VAS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF500-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_590589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462325.1">
        <property type="nucleotide sequence ID" value="XM_025616045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VAS1"/>
    <dbReference type="STRING" id="1450535.A0A317VAS1"/>
    <dbReference type="GeneID" id="37118188"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ysc84 actin-binding" evidence="2">
        <location>
            <begin position="91"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY69010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="326" mass="33600" checksum="DE2E672A2D0316E1" modified="2018-10-10" version="1">MPGGIHNPFPSSLQSECDKAAQIIESFTNPDAFNSPGHTIPRKILTGAKGLAILTVAKVAFLGSGRIGSGVLVARLKDGSWSAPSAIMSLGGGFGGQIGVELTDFVFILQNDLAVRTFAQLGSLTLGINVSLALGTLGRNGEIASGVSAGGVIGMFSYAQTKGLFGGVSAELSLLVESRLANRKLYGNKAKAPELLGGEIPPPEEASALMRALQSDVFNDTGVELSRGLASEEPPAEVTIAIPSELPSEVVSERAVELPSEAPSEAQGATSSQPTPIRMPSVSDVINTPPELPGSIQELDATPVQPRSSDQHDPVCAPPSSANRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VD09</accession>
    <name>A0A317VD09_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_539376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463207.1">
        <property type="nucleotide sequence ID" value="XM_025612695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VD09"/>
    <dbReference type="GeneID" id="37114838"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="58" mass="7009" checksum="49B2B9421DF5822E" modified="2018-10-10" version="1">MDERERKAKGREKRKKEESKMLNADPGKRKRRRRGGGGGREGGVEKREEERRKREKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDS1</accession>
    <name>A0A317VDS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_261893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462807.1">
        <property type="nucleotide sequence ID" value="XM_025606497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDS1"/>
    <dbReference type="GeneID" id="37108640"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY71052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="117" mass="13294" checksum="B27805CF1A56B778" modified="2018-10-10" version="1">MGTFASTSYGTGYIPPYSHTHKHTSVHAYMHAYRVLILLPTLSAMHQEKINNPITKNTMEKRKVKRREEKKRRRGSNYIPDPNPTSSSPSLSPHARTIIIPSLCVARRSICTPYETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGV9</accession>
    <name>A0A317VGV9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_254012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463201.1">
        <property type="nucleotide sequence ID" value="XM_025606453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGV9"/>
    <dbReference type="GeneID" id="37108596"/>
    <dbReference type="OrthoDB" id="4150467at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="601"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="332"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="414"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="414"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY72248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="688" mass="75001" checksum="C08D9248C7B49392" modified="2018-10-10" version="1">MQAVYYEQHAALGELPTYTDHRAPQEPSPRSSVPKNVAFELLLDENSKVRARIPMRVQIYPHDTTDSIVTTVKNFYGIYDGAASGVSFEDEYGITLIARYENLRNNMTVYVRVIPVQAYTDGYGDRYYGHIPVEARKRPSLGEPFQMAPAMQPAHVLEHGQPPSRPASRLARKRSISPSGRSRRSASQHKQSSRMGNKSRGSSAHGSFREDGTPGYSDSEGGYSGTKKSRSEQFGSSDISMDNILQDGRRKRPKFESSELPLFVPPQVPLTTSTSSISPQRRSIGQEGAISPFARPTQRPSNSQQPLPSPQSYGYNEQAGSVSAVRNPVYATPVVPEHGGHRLRDRATTQSSGQYSNQAGRGGGPGILPTPDPTIASCISDEDVAMQLIRLGDASNFSHGRTSASTLDDAFSGAADAASSTGATSDGEDYSDEDDDLPARTKQRLDSSPMLPPGTTKRTHKRLDDILPSFDSSEGSYDGYDDEYHHEEYPDNQTRHEIDEDSLYRESAPKSKKAKTRPTNPVVAKARAPKPAPVRQNKSSKPATTNGTVRKVKSTSTAVAQKVAVSPQMMSPVPARKTSTSSVNFQHQLAADEEDLSTKPRCQRCRKSKKGCDRQRPCGRCKDAGIGLDGCISEDEGNGRKGRYGRHMGVPVKKAFEPAVNGVETQSIVAAIPVCSAALVDKSKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIW2</accession>
    <name>A0A317VIW2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Beta-lactamase/transpeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_525903</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463016.1">
        <property type="nucleotide sequence ID" value="XM_025610331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIW2"/>
    <dbReference type="STRING" id="1450535.A0A317VIW2"/>
    <dbReference type="GeneID" id="37112474"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058664">
        <property type="entry name" value="ARB_00930-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051478">
        <property type="entry name" value="Beta-lactamase-like_AB/R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935:SF95">
        <property type="entry name" value="BETA-LACTAMASE-LIKE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22935">
        <property type="entry name" value="PENICILLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26335">
        <property type="entry name" value="ARB_00930_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016363805" evidence="2">
        <location>
            <begin position="20"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="73"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-like ARB-00930-like C-terminal" evidence="4">
        <location>
            <begin position="405"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY71780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="561" mass="60036" checksum="2A76D39641957057" modified="2018-10-10" version="1">MRLTQSLSILLPLATQALASCEPEIPFHPPKYTPDSLSTVFNQVDASIQTLVAAGVFNNTSFSVQVASRDGPLHAIYHAGQDTANPVNGSSAYRVASNTKLFTALGILKEEAAGRLSLDDRITKFVPALRGVGNKIQWENITLRTLLAHLSGIPDNYAEDDLVLSLSDPTVVGLPPVTAEEKAALPTCEGFSDYETACSFADLLDWVEDATPVFPPKREASYSNVGFDLLGLVLANVSNTTYEQYVQRAILQPLNLTGSAFTPPATGIAIEDSYWGVDLGAGNPSGGLYSSANDMITFLRYALVHANSITPALNWFLPAAYSSGSHSYLGYPWEIFRSPAILPNSTRTVTMNTKGGGLTGYYSYSFILPVYDLVLFMGVAGDLTGLNDLLDEVVDPIVVGAETIAQKQLNATYAGTYVATDIGLNSSLTLSHSLQQSLYISEWVSNGTDVLAALVPLVANQAGTGDNIYFQIIPTFETRVAADGNVGEVWRLINVMNGNGGDTETRGNATSIWADYCVSNIDPLAYAGVALNEVVFWRAGNASAPVIEAELSAFRVLLAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VK68</accession>
    <name>A0A317VK68_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_627569</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463631.1">
        <property type="nucleotide sequence ID" value="XM_025617433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VK68"/>
    <dbReference type="STRING" id="1450535.A0A317VK68"/>
    <dbReference type="GeneID" id="37119576"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF33">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="14">
        <location>
            <begin position="102"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="13">
        <location>
            <begin position="239"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="652"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY73879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="671" mass="75816" checksum="ED7DBB13C67DA661" modified="2018-10-10" version="1">MSLHPLDPATAEEIEQATSFVKSVYHGVPLHFKCGGLQEPPKAALLEFLDAEHNNKPLPFLPRCIFLNWYIKKTPRLFEAVVDVTNGAFVYHTELPRDFHGPVDRAEMNEAAQVVLADPAVQAEIKRLQIDDTTVVLDPWDYGVDGEETQERHTQVFMYMRNPKNNDPDSNHYCFPLDFMVIVDLCAMRVKKIIRLPLGADESVTQGSNVPHRRTDPAEPEYDHRLQKSPPRTTMKPYQVIQPEGASFTVKGHLIEWEKWRFRVGFNWREGLTLHDLSFDGKSNFYRLSLAEMFVPYGDPRNPIYRKGAFDLGNVGAGVTANNLQLGCDCLGMIKYIDGHVVAVDGSAAPRPNAICIHEIDNGIQWKHTNHRTGKATVVRKRQLVLQTIITVANYEYIFMWYFDQSGEITFETRATGILSTQPIGKDVTVPWGTRVADGVMAPYHQHLFSVRIDPAIGGHQNSFASTDSVAMPWDDQLNPLGTGYVTEQSILDRAGSVEDDVSKGRVFKILNENIENPVSGTPLGYKLVPHRSQMLLAKPGSWHWRRSEFAEHSIWVTKYHDDQLFPAGKYTNQSLGGTGIKSWIEDRENVRNEDIVIWHTYGLTHNPRVEDFPVMPAEIVQVHLKPYNFCLFNPTNNVPPSNQKANQSVAYKAPEPEPEPVGPVCCKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLZ0</accession>
    <name>A0A317VLZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin cytoskeleton protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_524502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463772.1">
        <property type="nucleotide sequence ID" value="XM_025610268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLZ0"/>
    <dbReference type="STRING" id="1450535.A0A317VLZ0"/>
    <dbReference type="GeneID" id="37112411"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY74579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="260" mass="27854" checksum="6727D03FD45E9544" modified="2018-10-10" version="1">MSERSTVHVEGIAPATTDKEVQDFFSFCGKITAISVTPVSSEAEAQKSATVTFEKEAAAKTALLLDHTQLGPSVVHVKAAQTLDDIAGEQAVSAGQAKDEHNHDLEQEDKPRSRIVAEYLAHGYTLSDSAIQKAIALDQKHGFSSRFTTALTSFDQKYHATDRARGLDESYKISDKATTGWRSLNHYFEKALGTPSGRKLRDFYSQTDKQVRDIHAEARRLADLKSGKPAEGGEAPAATGAPSTAPASQPAGTAAPAEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPZ5</accession>
    <name>A0A317VPZ5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_524278</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463968.1">
        <property type="nucleotide sequence ID" value="XM_025610256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPZ5"/>
    <dbReference type="STRING" id="1450535.A0A317VPZ5"/>
    <dbReference type="GeneID" id="37112399"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF10">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY75341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="509" mass="55675" checksum="EA65B258175B590E" modified="2018-10-10" version="1">MVRVPRGCQACAEGHLQCDGKSPCGHCKGRNVPCLTQARTFKFRNEVPALQQRYRASPPSSTSTSTSSNSTASTATNSSPSLPSTPRSGPARGRDVQFAPVPLPLPLPLPMDESVSPSLTVTAVAAQQTQVFTNYVLTAFPCFFKCTETRVPVNWVEYVDRRRGAMNSCFDWAIRACTLAYSGALYNVPEFHDAARAFYTRSLRGLAGLLADESTAKSDEALSTAIVLAVFEKHHCTGPQAWIHHAHGIRALLKLRGPKAHLHGFGRAMYIVYRPILIAAALIEGEACFLEEPEWHSLNEQISNDNAKLPDSSLYTDVVDRGLREIIKIPGYVKRIRELIALPLAKRAKLEPPLLQSVQATRAALRGIHTEFGVSISMLRAGHAKPRGFIGPLPEFFFEGYSAHVTRGVHSALLILDYLVVMLDPSQRSTTLPREPRRLSSPPSPSPAESASPTPSYDSPMTPPSSPGQPQLVVESLITPNYKQGPTTDWMDQLTSTMGMDGVRVRIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQW2</accession>
    <name>A0A317VQW2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_197700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I LYR family. SDHAF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464168.1">
        <property type="nucleotide sequence ID" value="XM_025606082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQW2"/>
    <dbReference type="STRING" id="1450535.A0A317VQW2"/>
    <dbReference type="GeneID" id="37108225"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20268">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045295">
        <property type="entry name" value="Complex1_LYR_SDHAF1_LYRM8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF1">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="5">
        <location>
            <begin position="9"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY76355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="78" mass="9336" checksum="7C5F5ACD40DC6F60" modified="2018-10-10" version="1">MARLSGLQREVLSLYRKCLRETRKKPIEMRENFRGYARAEFRKHASVSKKDFSAVEYLLRKGQRQLEMYSSPGIRNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRT4</accession>
    <name>A0A317VRT4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_473718</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463998.1">
        <property type="nucleotide sequence ID" value="XM_025608486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRT4"/>
    <dbReference type="STRING" id="1450535.A0A317VRT4"/>
    <dbReference type="GeneID" id="37110629"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="10"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY76001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="722" mass="80902" checksum="E3C11192BBCE2140" modified="2018-10-10" version="1">MFRRNGKPVSCEPCRVSKIRCDHQRPICGRCQTRQKESQCFYHPAPLTRAHRNPGPRPSRRTRATVSSSPAGHTPVTTRDDEIPQTPGYLGSTSFVSAFPRPELLFPSDVASVPSLSLPSEFCSAQVSYAHSQLLELISSFTEYQNLVVNYYQRGQFSIVPRNLVLNPLFKTGSYLEKWKHNRSGARQETLIEDLSRMSSTRLPIPSVDATVEDLCASFSGSSLRWEFVGIIFAFAGLAASYPEAGEPYQSGEFATEMFAASKTCIEICEQCSQLNDLSIWLRYLTVALASNLFGDTSNLVYRCLSDLVCQIFAMGLHRQSSLQERVPFFLSETRKRIFAATFTRDKNLATYLGRPPLIDSHFCDLLLPLDLDDDELTEPGNIPGPQGNSLDSDGWKTNEFSLVRSLRSVTGLRLRCGMAILREKVLRLSLGNRGTDQEAHLPGIVEDYQKAWEAVPQQYRYDNDAWNRLDPHSWVVCLIVYLDHCYTGYQLHRMRLRQNEDSRGPFLEAATKLLAAMNDFARRQAQTIALQRRYMWVFLFYGLPGAGSLVSELHRCSTADIPFPVPESRPRIIRDLSVLISWLEGSVFPNRPEYRTCLVISALISKLLDEVLLGPQMTLTVDEQTGSDFSIAAGRRARRTANPAASPFSGVTDSQSSQLVASSFPTMTTGPDPLHGETVDTGFPPDLADIVSSEDCVNWLDGFSWDSHPWGEGWPLFPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUV6</accession>
    <name>A0A317VUV6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_472341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464668.1">
        <property type="nucleotide sequence ID" value="XM_025608424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUV6"/>
    <dbReference type="GeneID" id="37110567"/>
    <dbReference type="OrthoDB" id="5417811at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="328" mass="36972" checksum="C16095DA19B1F3DB" modified="2018-10-10" version="1">MLPPDRSLHVSSSGVIRDDHLRRASNREERFMSWATDHRLDLEQRILGDRAERRESRLPRRSTPSHRSLRDVAASHYAPRGPYVPIELQSAADGEARSHARSEQAPHGAHSTPDPESLRYRRSCGSKLKEKRVRRRLITLVVSTGFLILVVAIYLAFAASSTTLGRELQILLIFMILILGIVFCHSLTRFLMALLRRPDSDVATNRIPSRAGPAGYAQPARPIHVILAGDEDVTAASPSAVREKVTAPPPAYGLWRSSVRLNPDLLYWQRIENNNTQILKGVDRHASNKARIPRPPSYTSDNGVDYVIEAQPRSLTQWRISEESRRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVX0</accession>
    <name>A0A317VVX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_178616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464793.1">
        <property type="nucleotide sequence ID" value="XM_025605967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVX0"/>
    <dbReference type="STRING" id="1450535.A0A317VVX0"/>
    <dbReference type="GeneID" id="37108110"/>
    <dbReference type="OrthoDB" id="3903581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="602"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="672"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="855" mass="96126" checksum="6F2A742DEBF70BC3" modified="2018-10-10" version="1">MSAIPYPPVAPALERSEPVLSLLGKASGDQQDLVESALEQSVLPAQHALSTFELVVTTNAPILESLLLQTPTDSILKLYHTSRYLRSFLRSYPTAWKYLSFRLLYPSGTPPPLRVVLTGSSEILSPRQSRPYALDQLLMNVVVPFSPCLRSLELDNTAVSGQILISTVLHSRRETLEHLSVRGCKNVSLKYHIIPYLTMFGLQYDVNMEQNIGSSPATKHLALKSLYTYRCRHHRRRPYLTSSLSRKDSDSEPTHELVNLCHKLGIWTDTAWCSTPAGRCFRRRGYVSMRVPQGSAEVWVVFDRLWRSKNWIGPVDPASRPVQRDAKLWEHSETGYYGEALGTGEGRDPGEGKMVPAHLRRSHAQFIEKVRCDNCCEVIPERCEQCSILMHCVGCRKTLCASCAYERPYLHCQSRSGSSPDSSFWWAPGATMSPCSMQDPVEHSETTVTNSVAPSYPALTFHWCCTEPIFSGGGGISIGTPNRDVDQVRAVPLPRGQGWEDLEYSAQEWSKTFPKDAYGDPRKPDYTLETGHIAMMRWLLGPPDRQPAACPRNLCQDCYDTPQWKVHCKSCSKPLCIEHDLRGLRLRICGYKDLTVEKNAIQNSSETSSRGAGSRMPYNHSVPEFELPYRTQRILDSTTSSFTEDNHDGFGEASSTLHEHRPTPLIHRRSRSLSISNSNRSRSSSSPSSVYCDSPSAQPKWQGCQSFFCPQYRAAGDQRQRCPSVLRECTGCHVYVCEDCTSAHPPCNCSYCEVNYGCPECLKVREQDGTCRRPAEEKARQERKFKEDLRLLEGIVEKKLANEMAEFAGQFFDAVEGVRGERGEVEHIEEASTYPEDGMDEADLLAEETLTDSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVZ3</accession>
    <name>A0A317VVZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Kinesin-like protein KIP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_559043</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for assembly of the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464339.1">
        <property type="nucleotide sequence ID" value="XM_025614041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVZ3"/>
    <dbReference type="STRING" id="1450535.A0A317VVZ3"/>
    <dbReference type="GeneID" id="37116184"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000073">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000670">
        <property type="entry name" value="Serine/threonine protein kinase (Kin28)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 13" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="64"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="18">
        <location>
            <begin position="356"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="307"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="914"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="986"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1044"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="730"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="882"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="941"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="436"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00074598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY77152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1085" mass="119171" checksum="71F8CA94CBB3C377" modified="2018-10-10" version="1">MAVSPLIPYALSVAAPSSNEASKLEKAPAVDSPNKQRGALSPRPMTIPDREITEQLNEDVRHKYIKDKKLGEGTYAVVFLGHLRTDPSSFVAIKKIKVNAEYKDGLSMDAIREVKYLQELSHPNIIALHDVFSSKDQNLNLVLEYLPRGDLEMLIRDSNIHYGAADVKSWMGMLARGIWFCHENFILHRDIKPNNLLVAADGEVKLADFGLARSFADPYLNMTHQVITRWYRPPELLFGARQYSGAVDVWSMGMVFAELLLRVPFIAGNSDLDQISKICEAFGTPTEDNWPGVTRGAGDAKSVLTMEARDTEASPSQSRSSSAQGSYSTSATTFEDADEGQGVPKSTSKLKETKGNVIVSVRVRPDANGGEITKTTEWMVDGRQGVISYNGRESGDYSYDNVFPPHEHNAKVYDAAAKRLVRRVMEGYHGTVFAYGMTGTGKTFSMQGTATSPGVIPLAITDIFSFIRETPHREFLLRVSYLEIYNEKIHDLLSASVSGGPTSPQQEEIKLREDSKRGVYATPLKEEIVQSPTQLLRVIARGDHARRTGSTQFNSRSSRSHAVVQIVVESRERVPAGASQDRRSGLVPGGVRVSTLSLIDLAGSERAADDKERRTEGAHINKSLLTLGTIISKLSEARDRASNPTDREGKHLPYRDSKLTRLLQPALSGNSLVSILCTVQLGGTAKSHSGETLNTLKFAARAKNSIVSHAKRAEEAFGSGGGDAGSRVLLERYRMEIQTLRNQLESQTKAQAEKELRLEEQQLEQEAQIRHEEQMLEMQLARTALKERIEHLNRLILCSKSTGVNTQGNLSALGRLSRMSTGSRSLRSSLSQSTLGAYGHSSLRPISFLSVNSNEPSGNQHFSSGHLGHEEEDFIGEFADGKASAQRQIAALQADLNDKNRYISTLERRLLQARRSSHSRMSIGMKTGGGTPDAPDGLALLREKDLEINELRLQLDDKDRMLAALRSAARHRDLAHSAADAFVLDTKDKHGRQEHRPGGDDSPAYDSAVCLSSPINDEDPAEKKRSMDDVSRILDEMIQDRVESGQLIQGSHGSVRVAAESRRTSESIAGLPGLSMSATDLEGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWV4</accession>
    <name>A0A317VWV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Translation initiation factor 4E, mRNA-cap binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_522541</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464581.1">
        <property type="nucleotide sequence ID" value="XM_025610187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWV4"/>
    <dbReference type="STRING" id="1450535.A0A317VWV4"/>
    <dbReference type="GeneID" id="37112330"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY78069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="247" mass="27588" checksum="34B232EEA5934797" modified="2018-10-10" version="1">MAAVAENGHAPVADENAAPVAAAVEQKEQTEKTNGDSVTVFHDAENFNVKHPLMHEWTLWFTKPPSGKGDNWNDLLKEVVTFNSVEEFWGIYNNISPTSELGLKADYHLFKKGVRPEWEDPQNKHGGKWSYSFKDKRSVPIDDLWLHAQLAAIGETLENDGDHEVMGVVVNVRKGFYRVGLWTRTVGKSISGDKTNRTPAQGKEILESIGRRFKEVLRLKEADAVEFSGHTDSAHSGSTRAKAKYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXP4</accession>
    <name>A0A317VXP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_537759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464874.1">
        <property type="nucleotide sequence ID" value="XM_025612345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXP4"/>
    <dbReference type="GeneID" id="37114488"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="71" mass="7886" checksum="69406E4E7401B1C7" modified="2018-10-10" version="1">MALVACPFRIASAGTGAAVMWRYEADRHSTNWLAVAARFVPSRLVRILTPEKPGMGSVIGPHWYQQRFLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYD4</accession>
    <name>A0A317VYD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-PSP endoribonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_537807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464534.1">
        <property type="nucleotide sequence ID" value="XM_025612357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYD4"/>
    <dbReference type="STRING" id="1450535.A0A317VYD4"/>
    <dbReference type="GeneID" id="37114500"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06152">
        <property type="entry name" value="YjgF_YER057c_UK114_like_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF39">
        <property type="entry name" value="2-IMINOBUTANOATE_2-IMINOPROPANOATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="135" mass="15511" checksum="E4F79FD93F92D1F6" modified="2018-10-10" version="1">MSHLTYYNYDGVGKKNQQQFKYSQAVRIGDRIECAGQGGWDPATGVFYKEINEQIDQAFKNVELNLKDAGGKGWEQVFRVNSYHVPINNEALEAMVRNFKKYMPNHEPIWTCVGVTRLGEDDMRVEIEVVAHDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYL4</accession>
    <name>A0A317VYL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IFRD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_567705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464935.1">
        <property type="nucleotide sequence ID" value="XM_025614645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYL4"/>
    <dbReference type="STRING" id="1450535.A0A317VYL4"/>
    <dbReference type="GeneID" id="37116788"/>
    <dbReference type="OrthoDB" id="18978at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="3">
        <location>
            <begin position="67"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="451"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="458"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY79363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="479" mass="53770" checksum="64CB70F45CB98494" modified="2018-10-10" version="1">MPDLRRQVLESGKTISRKAASREGSRRTSRGNSTPNSHQSSRNPSRYGSDEEDLDSLSDDTAMSIGSLDDLTDNPDVDNNHDWVEELGDVIQDILDRKRSSNLSREEAYAAFCRLAKSHYIEEQIRGRVNDLVAAFGRSIKFETSVRETTLALRAIELLAISAYDNTIYENVEPLLTRTIRDSTSNAIKAAAIHCLGVSTLHAGAGQDGILDQMTFFLDIAASDGQSIGAGDDAQSVIAALQEWGVLATQVDDLETESEEAVEIFMEQLNSGDSALQIAAGENIALLYEKSYTPQEDDEDDEDEEEESEEESFLSSGRRNGPKLIKRYNAYHNTHELEQQLQSLATIHSKRISKRDKKSLHSNFASILTTVENPRRGPMYNTAIDQDTNRHYGSKLTVKIGRQGVMNIDRWWKWICLNSLRRILQGGFAAHYYQGNRAVLESLPVIMRMDTPSDRGTAKRTAKYRNSRRWAMHEQSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYS9</accession>
    <name>A0A317VYS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_558693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465086.1">
        <property type="nucleotide sequence ID" value="XM_025614020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYS9"/>
    <dbReference type="STRING" id="1450535.A0A317VYS9"/>
    <dbReference type="GeneID" id="37116163"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY79514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="538" mass="59922" checksum="FFDE540E5DFB8986" modified="2018-10-10" version="1">MPPSCYTCRRRRVECDMSQPPCGKCTKAGLECFQKRPLRWVEGAAFRGKPKSISARINLVSSTVDESPLTISEGISIGTSNRAYATWIDNSDGNVDSPKWLSRGASMGMLRECHGAGPLDILSIPPGLDDPSIISLDKTSRYYLYYYSKCLCKLFIMYDTNKNPLRNLIPAALEEPVLLMSIVALSAQHMANTTRRFYSSEGECYGVESVDASHSALLYKYRAIQGLSRAVNDARSYRRDFTIASAFLLIFLDLLESGNDNWNFHLEGIKKLINCISHTDGSQTTAQQGLGATIQGLRDFIVRQIYLIDTLGATCTRPRLLSRSTLSRSITSLQMSVDKAYLGCPDDLLDALRSFSISRDAMTSPEHLEDAEVYSRIQRVVTVLGSTRSFDCNAWAAGLSHPDPSSIPSTMLGKLAQSYKLGTLIYGTRVLDALTGSNTSLSNSLGELIDTIDALKSDEALFKCILWPMFVAGLESREGAQRQYVIECLEKFWFETKCINVVNAANLLRHFWKQEECSTMCSQWIFNIGQMEGDWLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W118</accession>
    <name>A0A317W118_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone transcription regulator 3 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_626134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HIR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465195.1">
        <property type="nucleotide sequence ID" value="XM_025617341.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W118"/>
    <dbReference type="GeneID" id="37119484"/>
    <dbReference type="OrthoDB" id="77564at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033053">
        <property type="entry name" value="Hir3/CABIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15502:SF7">
        <property type="entry name" value="CALCINEURIN-BINDING PROTEIN CABIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1763"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1793"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1825"/>
            <end position="1836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1869"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1881"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1917"/>
            <end position="1997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2005"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="2037"/>
            <end position="2050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY80336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2050" mass="232441" checksum="C3FE9BE58D2EDD41" modified="2018-10-10" version="1">MASWVALNIEPDEAVEEEVDDTKEIQIEEALKLYQNALKLHSQGPQFYAQAAEAYDALLESEIFKYPESVSDYKRVALHDPEPFHYDDAAGAGAAQALAEFDISDSTSSTLMQTIYLSYKNHGQYILDALRASLQDVSNSSDAAEDSQVKVNEKTRAALTSFAEALERDDSDLNLWRQSARLCSALQSYRLTRYCLESVLADDDNRLEIQTEQLGLEETFAEERLRGVLRSLLDRLSLAQVPLKKPKKALLKFLQRQADPYPYLPILPLDLRDTDPSKSPLALRSSRHEVKPVSPTWAAVGRSILQRLVEEEIGALETGPGTSIGISLPALSPEMKAIGSQRRASNAQVGDIKLNQQQDVVMSEETQPNVKIEGPDAVVEQVDDHSSIDQRAEKQLMESLEIQSTQPHNPGSQQETANAEEVDVKPHSSGRKRSSASAVTEDQADRIRAKARRTRLREATEDVSFQAEEVTLDLNKYYEDRLEGFTQADEWLFSTVGSLLSKFGVEDLGVIDDLRKQVCSTNESNDSANLIAVEDTGHLFARDLMDLLKNWDEAKSQVMHQPDNLSTLQDIRGMGKSGLAIFLEHSRKSTRKLGMKQVLSGEDELYMFLRTINDGWFHIHDVALCWLKTLLMPDFARCATDDMVPQDWPVMESAYTLYQWPDVLKETVVQLLLHEDEHVYKQMREHVDELENRILSSATEKSFTYTLKHFADLEMLQTLFELHLDVYASINNPNSEVDGRTRILQRDRLERWCLLARTSLTHFLEYSSPSNARERVVLRHIWASTFHSNMGRDIQREHVLLCLQELKFFLTSLNNPVINLVNNAVMPELSLEAVDQEISKLKSMDFFMRIFNPTSDDPVGLIETIEPILEPSSVLFVQDGLDEKESEQSASQLREMGSFLDRGDASLRLFLWRRLQDAYKKIEYPPKVVSCYLRSIETILRELRSPAHLEEPREHRQITLLRWLKSLDGILNKAVTTILHESDKAYECFDMDHLRSSMSAVAHLTKLLHSFALYEDLVRVGKLSGPDLRGALAKSLESLKDKLREMQVRCWILQYTLIKEAIAQNDEAFETPLEDRIHYLRSVHNALGIRRMCRFSHKQFLKLVRSELFTLDVKQDVELDICQILYDIYGIKLSPVDGLLYDHGCPPEKLDRSTAIVMVDFVMRQAKKMNIKDLSKSELKSTIDKMQQAIGTTKSSPPLSYNKRIITAYLKSPLNPSEIFRAIQGVADLPLIPVPAESAIIAQNGWYFLLGHAALTKFRSQKRLNPVPTTDLDDAITWFRQDLEHGTTRWESWYRLAQTYDSKLEEDITWSADKINNNRMELVTWQRNAIHCYAMAIATAIKHSAPTLETRAMLSDLFTDFGIRLYSSSRAPLSMGAFSLADFTRHFSNEESQRMYEGRPFQEMKLYTVWNLASYLLKRALVDKPKNWMTHYMLSKCLWKMYSCDESVRDTFTRIDVDVVLDSLLDAIDALPQRKDSRSDPIFEPHYKLVSIVHKLVHRGDLTAAEGSKTLLATPWARKVRPPEDQTAWKRYILDVLRNLKSADKSNWHHRMAVRAAHVVYDDDKNSPAAAAAAKNELTQQIFTKTMTIQVWRPEFERPGRHFVYTTRYAYFFVSLLDQLDDRVNLDQLLRRVRKKQGDFINHGKLWEDASLTYAKVIRRAGHISEGHEDGVFKPIGWEEFVTNTARLEELSQLSLESPSLLELLRDAIELKKLNNNLMKVSLLEDLIADLYARLYEVNMPQVIEQANEENKERMKVDHLLMGSDGVADTPTPPTSAPASEAPAPRGRTKGIARRDIQKRAETIVNRKVAPRVPTAKAPAITEAEQANTSEATPTSAPKPIKPDLLEPATEELGAGQQSDIPNSLHDSADDESELSEIDDEKLSKLTTERKLLFPNLDDRGSIDPESELEGTHEITGDLEEEGEREGDTELIEGEGDTMVEEVEDTADGDDDELEGDEENEAGGDEEIEGEGEGEGEDEDEDEGDQEDNGEPNDTVDMEGLHDGEDGDGDGDGGDDDEDVDDDAEQAEQAEIPGTDQESEDESEPEPMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1D5</accession>
    <name>A0A317W1D5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_548431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465313.1">
        <property type="nucleotide sequence ID" value="XM_025613399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1D5"/>
    <dbReference type="STRING" id="1450535.A0A317W1D5"/>
    <dbReference type="GeneID" id="37115542"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="144"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="462" mass="52091" checksum="6C0BD7BFEE567844" modified="2018-10-10" version="1">MSPSNLRSYWDYTFLWTDLHQTKEQLRPRIYTYDRLADECLERLDVLAPETVQDVQNDAAGPKKPRRDMHALMKDHARNDPKLGELWTQVNTVPEWVDWQQIQRGQDVFFRYGLPILNALNFGSLLGGISDYNIPRGSARVVETLARTGGFSADVVRRRLLETLQFVLQVSESLDAIKPGGAGHVSSIRVRLLHASVRSRILSLAKNDPDYYNVDECGVPINDLDCIATINTFSSIVIWVGLPRQGIWLRKQEINDYLALWRLVAYYMGTPDTPFASQPSGRAMMESLTASEFNPTDVSKLLAHNIILGLEKTAPTYASKEFMEAMARYLNGRQLSDRLGIPQTNLYYRSLIYGYRFFVMTLAYGTRLFPTLDQTLIAFRRKLYYTMITDREKGLGGESFYAFQYVPSYGKTTSPGKRRSSKPAAVGIEAVAQLGLLAALLAAVVVFSGGIYALRILTPAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1L2</accession>
    <name>A0A317W1L2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_184836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464572.1">
        <property type="nucleotide sequence ID" value="XM_025606000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1L2"/>
    <dbReference type="STRING" id="1450535.A0A317W1L2"/>
    <dbReference type="GeneID" id="37108143"/>
    <dbReference type="OrthoDB" id="5361617at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="46402" checksum="B8715D156F2CEDBC" modified="2018-10-10" version="1">MSTGRKVFHCAVDETALTTNISEIKKWTTNGAITLIVPLYTLERLHALKRAGSQVAINAREAVRFLDRVTSGKDNISAERVILQGPMEQYENWTEAEKFFLPEFEEEPEATTNGVLPDDQVAQRNREDKAKDMKNGAAPDDLSQMLLNKLNFKKESDAVSITSNGTHSAPASRASTRSSRTSPECSNSHVLANGGAFKDAKKKPESGHRRSASGSTIPTVPLMLRPLLSALLWRLHHGPDASNAAKSCILITNDRPTQVWAQKFGIGVKNIHQLRTSIQYEEREYKNRCKYVEKTQVTEPKSLLAYEDESDEDELVFVPRGRGNGASRGGGSRGGAPRKAATLKTAAPPVEATMEIPTQPIDPNSFSRSLGVAKQQQKPTVDLSTQSGAARGIAGASRNYSNNRRGASRGPSRGSSRGRGKLWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1V5</accession>
    <name>A0A317W1V5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_188564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464672.1">
        <property type="nucleotide sequence ID" value="XM_025606025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1V5"/>
    <dbReference type="GeneID" id="37108168"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="194" mass="20601" checksum="92D9E77E1DC6F434" modified="2018-10-10" version="1">MVPSLPKILYPYHPARPPACCNLRQALAGEGVRTQRTKSTLGTPGPEGALLAGWLGVVSFLMLTPGGVLASLTCRQKCPSVPAFPSLPSAEASVPGVRRSSRTIYLGRVGTEELPLAFRHAALGTAVSIGVSFKEYQGAAIFWPILLGVGKVFSYQVILLRAVEACLSLPCRREGYKGFAKPAVFYSVQASAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2L8</accession>
    <name>A0A317W2L8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_537453</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465000.1">
        <property type="nucleotide sequence ID" value="XM_025612270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2L8"/>
    <dbReference type="STRING" id="1450535.A0A317W2L8"/>
    <dbReference type="GeneID" id="37114413"/>
    <dbReference type="OrthoDB" id="167718at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000376">
        <property type="entry name" value="Putative RNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="197"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY79428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="340" mass="39790" checksum="BBCD0B00E678A46D" modified="2018-10-10" version="1">MGDKKRKLAEEATVPEVKKAKRDDKKEKKEKRKAKEVVEEPVVEKSEKKEKKEKKEKKEKKDKKDKKEKEVKKVEEVKVEEKEDKEEKKKEKKDKKEKKDKKEKKDKKEKSKSTDDFDEKPAPEPEAMDVDETPAEKENQKPEAEVAKEEKKEKKDKKSKKEKKSKKEQKTEAEPTDTPAAEEPVEEEGQYKKNTRFICFVGNLPYSADKDSLTKHFEKIAPVSVRVATQIDKPTKCRGFGFIEFDNYDRMKTCLKLYHHSMFDDKKYPPRRINVELTAGGGGKSEHRTAKIEAKNKKLFEERQRNAKEIQREKAKHEQGEEAGQDDFAGVHPSRRNRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W316</accession>
    <name>A0A317W316_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_626109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465168.1">
        <property type="nucleotide sequence ID" value="XM_025617335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W316"/>
    <dbReference type="STRING" id="1450535.A0A317W316"/>
    <dbReference type="GeneID" id="37119478"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="308"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY80309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="588" mass="65011" checksum="AC24C95AAE60E364" modified="2018-10-10" version="1">MPPTRRQRPKAVGGPLSLIPAYIDSFSSVIAAGIERSAAMIDEGDRPPVDSPEYAQNLSHLVTPVTEPLSNHSMPFAINSVARDDCSTSQASPAIVNQPLAPQQSPRSPQDPATTPLVTSPLVFGLSNHNLQGVVTIESAPAPQRSKYTGKISTQVLAKSAEELFQDEDIRIRVMRFFCPLMSFAEDIPMPAAAYCPIVEKSIADPYVYAYFTSVNCLFPILSRSQFLAEYEAFYLTKQSTDAAFVCCYYMVLALGARGSMMSTAPTDLFRLAWELYNRVVSTPYLQSVQVLLLMALELINCNKDGQAIIAVGTAVRIAQSLGLHRGISAHKQPYERGFVEKEYHLRASIWWVCYCLDKKLSFEVGRPSAINDIECDVDPPGDMPPTPVSDLVSPEDEAFFGQLIRLCQLQSTIITQLFCKSVTEGEDTALVEEIGALDEMLLTWKENLPQALRFDDQLAGVHSQTKSMGCVLLHCMYYNAMLVIHRAALFDMAPLQPLQQSQPRLVAADVVCLNSARALARIVNDLASSPYSWPVIRSTIPYLLNVLFTLYIGVMRNPRQWTSDSDVALLNTLRHCFSKASDNHVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5P1</accession>
    <name>A0A317W5P1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_147692</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465731.1">
        <property type="nucleotide sequence ID" value="XM_025605775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5P1"/>
    <dbReference type="STRING" id="1450535.A0A317W5P1"/>
    <dbReference type="GeneID" id="37107918"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="3">
        <location>
            <begin position="524"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY81663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="683" mass="75484" checksum="3FE477A88E87AB6C" modified="2018-10-10" version="1">MESFKSSSFTTHPNPHVASANRRPWWEVTHGMVIALITLAGLAWWALPFHVGATSEGIVLSKGEFSWDQITPSQSLAYHDCFDGFQCARLEVPMDYNRSDGQGRRFAIAITRLPAKVPVTDPRYGGAILINPGGPGGSGVAQVINGGRTLQITVDAETDPNVEDAEKLSRDKYFDIIGFDPRGVNNTTPGFSCFPNLFSQRNWELQVAAEGMLGSSEVAFWRTWDRAIALNTGCSASLTTPPRDGDEALGEHLNTPPVARDMLEIVERHGEWRERQGLARQHQHDRLHGYDRGQSLVARTRWNRGQEKLLYWGRSYGTILGSTFATLFPDRIHRVILDAVVDADKYYLGDGPNPVEDADAIFDRFTQYCSTVGPDDCPFWVQGGPAAIKEAYLALEDTLYNRSLPVRSSATRGPEVVTWSDLKIILRIAMYQPLQGFPLLAKFASELAKGNGSALADLKHGGRSPSCPSSRCLQAGPWSAECQVTGHNEAYSSAAILCADAEYLQSTGEEEFRSNWETLREDSSMVGDYWAGLLMSCVGWDLKPKWKLTGMIHHQFVFLVAELLGTFAANTSHPLLFVSNTLDPVTPLRSARKMTRKFPGSVLLQQDSEGHSTLAAPSVCVHIEIRKYFQTGELPPPETVCKADLKPLLGASPMIQERSAGEQKLYDALMEEAQRMPIARLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W645</accession>
    <name>A0A317W645_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_576719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465384.1">
        <property type="nucleotide sequence ID" value="XM_025615151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W645"/>
    <dbReference type="STRING" id="1450535.A0A317W645"/>
    <dbReference type="GeneID" id="37117294"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000528">
        <property type="entry name" value="Nucleoside-diphosphate-sugar epimerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY80782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="304" mass="33592" checksum="861E9DBEFAFC38A8" modified="2018-10-10" version="1">MTKTILVVGATGKQGGSVVNALLSQEAGVEILALTRDPSSNSAQRLVKKSDKIKVIGGNLDDADAIFRNAQKATSQPIWGVFSVTTVVPGSSTHDAEEKQGNNLVDAALKNNVKYFVYTSVDRGGDASFDQPTRIPHFITKHNVEHHLVNKAKGTDMEWTILRPTAFFDNFTPDFFGKVFTTCWKISVRDKPLQLITASDIGYFGAQAFLNPEEYSGKCVSLAGDSLTFEEMARIFKQKTGKNVPMTFGIVGRLIMWMMKDMGYMFQWFHDSGYDADIPALKRAHPGLKDFGAWLETESGFMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCC3</accession>
    <name>A0A317WCC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_586924</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466347.1">
        <property type="nucleotide sequence ID" value="XM_025615791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WCC3"/>
    <dbReference type="GeneID" id="37117934"/>
    <dbReference type="OrthoDB" id="10568761at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="249" mass="28560" checksum="38D1EAE494A147A2" modified="2018-10-10" version="1">MSTSNNSVPLPEMASIPQKPTMPGTFPADINLESPKEDATATMTQDMDKVAISVTSPENKLSKKWTTTTLAIDPKPKPEYRGPVGTQTRPFDSYVEHTFLKKPMVSMICVEWCDHYHPESKELCLQKLVQLFQRLRNRNPTWKPIYGYTRPYDGSLQLYSDCEPVQGDELADGMIRVLQYQYHGQKSFKDYETGDSCLVGQWQSVIPSNKLAQEDLDIINYDDGKLQPLTEDDEEKRVEKKNEEEEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD61</accession>
    <name>A0A317WD61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA polymerase</fullName>
            <ecNumber evidence="14">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_536623</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="14"/>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465927.1">
        <property type="nucleotide sequence ID" value="XM_025612057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD61"/>
    <dbReference type="STRING" id="1450535.A0A317WD61"/>
    <dbReference type="GeneID" id="37114200"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000001">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="9 14" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase X" evidence="16">
        <location>
            <begin position="60"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="13">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY83142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="386" mass="43843" checksum="BF5CDE5E2E0B17BA" modified="2018-10-10" version="1">MDSDEENAAEASDSEAYDSSGPRPVKKKRKAVGKEDEVVDAWQQKFACMQKHDSQSAVENPNSRTIAVLQQMLDYYTRTDDHWRILAYRKAISALRRQPKKITIKSQALAITGIGERLADKIEEIVCTNRLRRLENINSTPEDRVLQLFLGVYGAGITQASRWMAQGYRTLEDLKTKASLTKQQRVGVDHHYDFSQRIPRKEVETHGEIVRKAVQRVDSKMQVIIAGSSRRGAADCGDIDLLITKPDTNIEQIRTIMLALVVPRLYKQGFLQASLASTSRDGSKWHGASMLPGGRLWRRIDLLFVPDSEIGAALIYFTGNDIFNRSMRLLASKKGMRLNQRGLYTDVLRGPQRVKLTEGRLLEGRDERRIFSILGVPWRPPEHRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDC5</accession>
    <name>A0A317WDC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-histone chromosomal protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_536071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466441.1">
        <property type="nucleotide sequence ID" value="XM_025611933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDC5"/>
    <dbReference type="STRING" id="1450535.A0A317WDC5"/>
    <dbReference type="GeneID" id="37114076"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="8">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="6">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="68"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY84516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="104" mass="11963" checksum="B9DF04138AF87DA5" modified="2018-10-10" version="1">MPKEKTTTRKTKARTTERRKKDPNAPKRGLSAYMFFANENREKVREENPGISFGQVGKMLGEKWKALSDGDRRPYEEKAAADKKRYEDEKASYNAAAEEDEESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDJ8</accession>
    <name>A0A317WDJ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">EB1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_575881</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466409.1">
        <property type="nucleotide sequence ID" value="XM_025615105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDJ8"/>
    <dbReference type="STRING" id="1450535.A0A317WDJ8"/>
    <dbReference type="GeneID" id="37117248"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035372">
        <property type="term" value="P:protein localization to microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1430:FF:000005">
        <property type="entry name" value="Eb1, isoform E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="11">
        <location>
            <begin position="2"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="12">
        <location>
            <begin position="157"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY84484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27062" checksum="423DA7CFED250AC7" modified="2018-10-10" version="1">MSESRQELLAWINNLLQLNLTKVEQCGTGAALCQIFDSIFMDVPMSRVKFNVNTEYAYLQNFKVLQNIFAKHQVDKPVPVESLTKCRMQDNLEFLQWTKKYWDQHYPGGDYDAVARRKASGGPAAAAGGPRAGATSAGAARRGTTPTIGGAGRPRVAGAASAANVSALQQEIATQKEAIAGLEKERDFYFAKLRDIELLLQSAIEADPDMEKDEDSLAKHIQGILYSTEEGFEIPEAEGAADELETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDR9</accession>
    <name>A0A317WDR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_116248</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466349.1">
        <property type="nucleotide sequence ID" value="XM_025605541.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WDR9"/>
    <dbReference type="GeneID" id="37107684"/>
    <dbReference type="OrthoDB" id="3235083at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1740" mass="185971" checksum="F55671F6576CE2F7" modified="2018-10-10" version="1">MSQDSAKASYLSSSKYGYDFVVSTTQASINSDLLAFLDQEDMPELYLCFLADPTTGDPTEQISLDDLKTQTGIDPFQIPADTPYDDDQITALTKARFIIGIRIQMGLPRNVEPKSLQPVTLGDDARRVGFRMYCRELDVIQNTPANGWGNTGTWNVWSQPSDEAWSLETQVDLVTQDLDKDLDTPYLNNNPDLKAQLESQLKNLSGTAFSLQQLLYDLDSAVLQSVPTFGDIPPGSALDKAQEAFTQIYSKNATETGLPLLSIQAVVQTDDNSSLTLTDLERQINPNSDDTRVSTLDYLCAVDGKTLPTATAFGWNWVAPDEVNSESGVMAINRNTFAGYLKDNLVTLVRPACIAVTDVTVNGAWSGLDADFSFYATLTSYQQPQGIVLTDASNAAAVHLEYSSEKLDSAHIGLWYAKLWIKSNYNCDVSFEGTNTIHIVQHLVIWVEVLVDSSGASGNIADYTLNENYTLSVDQAGNLQLSRQSSDLTNKSDDPSVNGFINAFTGINEVIDDVKDKAGSFAAAELQEVSFDSLRSFVFPGAQVFTFKDIRFSDYHDLLCDLTYVKPTTHTPVRGTAPVNAARELTASCELMQNYLSGELVSPTGKFTALQTDRGLSLVFAVDTAGVLHVLEEQSGRTHTGWQVRDLSTAALQKAFPGRSDVVVHTFDVAQSALDGSIGLMMAAAVDDTDHLFVSLFNSSADPSWTTAPLWTAIPFDATSETAGLVISGMMFAEVFGQKQYLIVDTERASDATVKDITRYVVNPAATEGSRWVKAGIPVDVESTRYQSCVGRIPGGRVDGVYTSGTVGESSQLVYVPLENPYGDGPPETVRLSLPSDVHPTAIAAARDSDLKSDKYGSTDLYAVSDATLYRYDPDDESQATAPSALVTNDHLAGTDTLFAMTHDGVLTLWGKNGSDVVYYLACPTNQLSVPGAWTAPVPVLTGIERLSPYVNRADGGRTVFAAGGGSVQKLTQGPSTAGSLWRPQRITLVAAPTEPALSFNSYTTTLQVIGADKLPVRDVPLSISSAAATPVYMNGLYYVLGSTPVSVKTDAMGTVTVIEATDDLQGTPLTVTMVDDASGTPLVIRPLDTAWKKLAQLNSSEALRDAHVPADTVAGGVLGSTTTAPLVDSSVGDSDVQTIAATMDQLGTAWSSIQSGSTKAWATRNRGVVPATLFQGRPQASGRGISDWIAMEAGDLFRWLETGVEALVEVIKDAATEAWHFIAHIAGEVYAAVLDTVEAIVGAVKWVFNAIKTAIEAIIRFVQFLFEWDDIRRTKNILHNLVRLFFQHKIGQIPKVKASLNASVAAVQKSINEWADITDWSALGSTASQTPAESSANPMQGQTSGSQLLAGHLRNHASDLTLVGGTPSASITEDLVANLLNALSAEAEVLGDVYTRLQTLAFDFQSLSVEKVLQRLVGILVDGALSSAQVVIDALLDLLQTLADDALSLLDAKIHIPVISDILNALGVADISFLDLFSWIAAVAYTVVYKVIEGEAPFPDDDNSAALIAATSWDELAQLFSSPQAAVASRSINLSTTAAQGVFVATHAMGGFTLLMSNFLTVFEAESLTEDNVFATPSAVIQGITTACVGAGDFLVPKDAVENEAMTDLSYVCTALGIAKTALGFTPIYGKLATASSKFPGLKLNDGRAVAAVLDVVLIIPQLVVTGWHFHELAQKDASADRSAAIVGEVASLAGDVSTVSYAVAVNDDEEESRQVFIGIMVASNVVGAGLLTAESIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEL9</accession>
    <name>A0A317WEL9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_494748</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466145.1">
        <property type="nucleotide sequence ID" value="XM_025609240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEL9"/>
    <dbReference type="STRING" id="1450535.A0A317WEL9"/>
    <dbReference type="GeneID" id="37111383"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="364"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY83677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="445" mass="49402" checksum="F74F61AC42391607" modified="2018-10-10" version="1">MAADGLSVRVLPTINPAAGHTFIEPTKRIHEHGDVSEFLCSKAYVDITTFLLQLNRSMFPAKLPDGTIQTWPVNSDAVEYSAPVRQLQQLLSKLEAILEEAPPDQGPRRFGNISFRRWYEIVESRVSSLLEECLSAEILEKKSANPDGPTAAAELKAYFLGSWGSPQRLDYGTGHELSFLAFLAGIWKLNGFPQSSSGVEERAIVLGVIQPYLELVRTIIKTYTLEPAGSHGVWGLDDHSFIPYIFGSAQFAPALSEADRVPEEGSLPDAPDPTGVAKATIVERERRGNLYFSAIGFIYDVKKGPFWEHSPMLYDISGIKTGWAKINKGMIKMYNAEVLSKFPVVQHFPFGSLFSWDRDPNAVPPPSTVHTTSAPQPRASELPSQVPGPGTKAPWARSQAQERQPEAQLYLTLLGYHLVRWRLREPHGPVHRQGRHLVISTPEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFP7</accession>
    <name>A0A317WFP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_586887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466306.1">
        <property type="nucleotide sequence ID" value="XM_025615786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFP7"/>
    <dbReference type="GeneID" id="37117929"/>
    <dbReference type="OrthoDB" id="3434980at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="74" mass="8901" checksum="F3D1BFF3E24D49F7" modified="2018-10-10" version="1">MSERKRIYYTYKTIEAYEKYDDQVRKIITEDTKREVWICNRALPPTCYPPEVSPDTIKKLKDLSDDIVVKELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHI8</accession>
    <name>A0A317WHI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_110550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466622.1">
        <property type="nucleotide sequence ID" value="XM_025605501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHI8"/>
    <dbReference type="STRING" id="1450535.A0A317WHI8"/>
    <dbReference type="GeneID" id="37107644"/>
    <dbReference type="OrthoDB" id="2533647at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="231" mass="26868" checksum="D1C24377BA2346C7" modified="2018-10-10" version="1">MVVNITAEDPQPTIHSHINGTTEEILDRLCVTELLKGWPVYRDASEWAHYRNCFAEQAYIFTTWSGGMPIDEFIEVSKKGRRNGDHIMHRENGTLVELNSKTGRAVGKMKATITQRFSFDGVEFDVECDCRFIMWCQKDPTGWKVHYKRLFYEKDKILPVDGKNVPDFSVEELKPYPYGYRYLGACQARLGHKIKLDLPTMEDNDKFRGMYEAMEQWLRGEDIKETLGIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WIM2</accession>
    <name>A0A317WIM2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_517318</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466915.1">
        <property type="nucleotide sequence ID" value="XM_025609989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WIM2"/>
    <dbReference type="STRING" id="1450535.A0A317WIM2"/>
    <dbReference type="GeneID" id="37112132"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="11">
        <location>
            <begin position="130"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="498"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY86324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="552" mass="61033" checksum="83432E2F3A773302" modified="2018-10-10" version="1">MTTTIVTGTGRRSSIRLPDLQAPVASSISQQMTSPIDKFPPFIDEVYETTAESRETHSNTSVRYAPTDRWEPRKQIQFPRDHKHGPALNSKRRSRKSISEAFSTIRTRNGSVSANAQELAEALRAPVSYKLIVLCLIWYTTSALTNTSSKSILNALPKPITLTIIQFAFVAFWCLVLSYLSTTLPWLKDSIPALKNGIRPPSRDVVMTALPLAVFQLAGHILSSMATSQIPVSLVHTIKGLSPLFTVLAYRVFFRIRYARATYLSLVPLTLGVMLACSTAVSTNFFGILCALVAALVFVSQNIFSKKLFNEASRAESEAETSSRRRLDKLNLLYYCSGLAFILTLPIWLICEGYPLISDFMQDGAISLSGNRGSLDHGALFLEFVFNGVSHFAQNILAFVLLSIISPVSYSVASLVKRVFVIVVAIIWFGSSTTPMQGFGIALTFVGLYLYDRNNHDDLADQRANSDHFRTRETVLPLNARTTGKTWDSSGYASLASKLSHHQPSGGPASHMSDPKKEDDEQGRARPRGSSSSRVWLPPGTKQKTTWQRNHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJA7</accession>
    <name>A0A317WJA7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UPF0057-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_624645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467044.1">
        <property type="nucleotide sequence ID" value="XM_025617235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJA7"/>
    <dbReference type="STRING" id="1450535.A0A317WJA7"/>
    <dbReference type="GeneID" id="37119378"/>
    <dbReference type="OrthoDB" id="2152119at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF42">
        <property type="entry name" value="UPF0057 MEMBRANE PROTEIN ZK632.10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY86453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="95" mass="10497" checksum="E82A9718A917A1DD" modified="2018-10-10" version="1">MAGTCSMLCLILITLFIPPLGVFLISGCSVDLLINILLTILGYLPGHIHAFYLEYVYYGNRNAGEVTAPRRAPGVYSERIQRGGHHHHQTYGTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJN0</accession>
    <name>A0A317WJN0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_466795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467120.1">
        <property type="nucleotide sequence ID" value="XM_025608179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJN0"/>
    <dbReference type="STRING" id="1450535.A0A317WJN0"/>
    <dbReference type="GeneID" id="37110322"/>
    <dbReference type="OrthoDB" id="4444391at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151">
        <property type="entry name" value="BLR2777 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151:SF3">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="1">
        <location>
            <begin position="36"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="295" mass="32827" checksum="5F13EBD191383EDD" modified="2018-10-10" version="1">MNEKAPADQISPVPSEATFTNNHLEALDKLEILPQILQEGILFAGSGAALLLQAAYPNIRNAFDDLTQTTTSSTSTSTSTTNLATTLSNTLQTALSYIACLVFGTPTEKHHLLTLLQKSTPPLPHKLPPDTPTQLWLTATLYATATDFYQRIYGRVDYRTAERAYMEFTTILSCLNIARDVWPPTRQAFWVYWDEQIERLSVSAEAHRFAKDLLDRSDLPGWVMAVKPLLRVITIEMLPPRIREAYGLKSSAKTRGLYRGTMGFSVAVYPALPGSVRGYPLRFYLGELRGRLGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKN3</accession>
    <name>A0A317WKN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase synthesis protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_535173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467264.1">
        <property type="nucleotide sequence ID" value="XM_025611719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKN3"/>
    <dbReference type="STRING" id="1450535.A0A317WKN3"/>
    <dbReference type="GeneID" id="37113862"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="372" mass="41430" checksum="26981FBDE0637D73" modified="2018-10-10" version="1">MNRALSRGLWCHRGVLCAPTYCHVIRPFTSLSCLRTEQPSSEVSTVSLKQPASDSSPHGPWYLQGETAVPKSQQTSPTNALFEHLSQLSDEKVRSELGEGPEDRDSTLFLRLFHNQLSISSAEEKAIAQVNLFCSAVSRQHPGYTKQGLYTAFLECSCLGYSVSDDLGFSVVSALLTPRSGGQVPDSDKDIALRVLEHLSLRGTDVVNMKVFNMIYQAAAISPSPTGALSRVSRLIDTLDLPFDPLQARSLMVSHFQHGDYNGFWKLWRKLPLNGSPRTVADYEMLFRLHADLGDKLRARDCLSTWVPMMSREQPPIPLRGELLVDIKHCLVLADPHIAQKAAEGSTSILVRFWNECQSKTHWSKPAKRPCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKU2</accession>
    <name>A0A317WKU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_596303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467324.1">
        <property type="nucleotide sequence ID" value="XM_025616250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKU2"/>
    <dbReference type="STRING" id="1450535.A0A317WKU2"/>
    <dbReference type="GeneID" id="37118393"/>
    <dbReference type="OrthoDB" id="4840035at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="273" mass="30353" checksum="C7C913605B7EDB38" modified="2018-10-10" version="1">MAEHKINFTSFQYYPEQLCTRYDLQKAIEPLTIYADDGRLYMANTVRGNPSPLPPEVLQEVRVWIERPHSKMIWLEGDWLPEYGSTLSLAAMQLCDSSLNARLPCVSFWGKPIYTFPLGTKKATSNPEAATVALLYSVISQLACLAPMYLPAVPELSQQQFDLLDGSIASASTALDIIEALLALGPRAIVWIIDGLQLAESQSTILALRGFVDILKKQEDVRLSKTCFTTDGNSNVLMRAIGVCNRIDASRTPRWTRLSGGEDVFAAFDRWCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNG8</accession>
    <name>A0A317WNG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="15">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_535437</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Mitochondrion inner membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
            <orientation evidence="15">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="15"/>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467529.1">
        <property type="nucleotide sequence ID" value="XM_025611782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNG8"/>
    <dbReference type="STRING" id="1450535.A0A317WNG8"/>
    <dbReference type="GeneID" id="37113925"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 15" id="KW-0288">FMN</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 15" id="KW-0520">NAD</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="16">
        <location>
            <begin position="379"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY87321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="497" mass="54577" checksum="077937939246BFF5" modified="2018-10-10" version="1">MISRAAAPSSSPLATLSSRSLRAQAPAARTFATVQDNAPPVRHHGGLKDQDRIFTNLYGHHGADLKSAMKYGDWYKTKDIVLKGHDWLISELKASGLRGRGGAGFPSGLKYSFMNFKDWDKDPRPRYLVVNADEGEPGTCKDREIMRKDPQKLIEGCLVVGRAMNANAAYIYIRGEFYHEATVLQRAINEAYEAGLIGKNACGTGYDFDVYIHRGMGAYVCGEETSLIESIEGKAGKPRLKPPFPAAVGLFGCPSTVTNVETVAVTPTIMRRGASWFSSFGRERNAGTKLFCISGHVNNPCTVEEEMSISLRELIDRHCGGVRGGWDNLLAVIPGGSSTPVLPKNICDDQLMDFDALKDSQSGLGTAAVIVMDKSTDIVRAISRLSTFYKHESCGQCTPCREGSKWTMQMMQRMEKGQAREREIDMLQELTKQVEGHTICALGEAFAWPIQGLIRHFRPELEARIREYSKEVGGNGPYAGGWNPEARAEGKLISPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQG9</accession>
    <name>A0A317WQG9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC45-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_50274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468106.1">
        <property type="nucleotide sequence ID" value="XM_025609458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQG9"/>
    <dbReference type="STRING" id="1450535.A0A317WQG9"/>
    <dbReference type="GeneID" id="37111601"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="203"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="739"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="745"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="769"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="849" mass="94336" checksum="6A2FB1DD7BE90F4E" modified="2018-10-10" version="1">MYLPRQLISHLYQQLLRSHHPLSPPVLILVTLEPDALCACRILTALLKRDYIPHKIQPVAGYGDLARAGEELVKPMRTANGGSGGVVVCLGVGGLVDLSEILCLSNAEEEEEEEDMGGVEVWVFDARRPWNLANVFGGERQPAVGEMNANARRKTRGVEKGCITTGYTSRNGGIVVYDDGDIEEELGKERDAYCELLAMPEVDEEEDDADDSESDRDADHPSSSDSKKRKSWSRQDDDDDTDDEDGPPRQRRRSDSGSYLISSPSRPRTMAHDSSNSSRSVTPTSDSPSPVQPKPPSARTLRRRLLRLKRKHEGVLQSYYSSGTSYSEPISSLVYSLASELGREDNDLLWLAIVGVSSLELSGRTMSGVGVSNALEYGGSAGWGGERGERIRQILRDEVLRLNPPDPYERDRDIRGEINGVIPTTARSPTDKSIRLSPEPRFILVRHWSLYDSMLHSPYLASRLHVWTENGKKRLHKLLAKMGISLNQSHQSYTHMDMELKRVLRQRLLKYAPMYGLDGLVPPEASGHAASREGWGFVRCWGWKACLSATDVGVIIGAILEVGPEEAPGAWDAKRASRTAQTANDDGSTESDLASLLPRFWSAYDALSLTSESPTLLQTSLPLAQHLHRAILRTGTSLLAKHQIRHLRAFRIAVVKDGPDVKLFTNPGALTKLALWVAEAIRVQERERGDTVKVGRRRALGTPLVLAGLDEDRDLYVVVGTGGGGGVVDFAALAKRREERRKKKEAKEKKRKEREERRAKRAAERADNSDEEEDTEESSSESESESEDEQDLRTNNHLLRNRFGIAFQEVVQETSARVRIDSFEHCVVEVQKEDLGGFLEALSFRSVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQQ8</accession>
    <name>A0A317WQQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_61657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467814.1">
        <property type="nucleotide sequence ID" value="XM_025616806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQQ8"/>
    <dbReference type="GeneID" id="37118949"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY88031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="189" mass="20471" checksum="03ED7904B570594B" modified="2018-10-10" version="1">MILGRNVYRFTRVNNRNRGVHISLGFSMIATGNHIAHVADHSGLGAVASTRPPLLGTSDETEAADAATLEQLARFLVISANETDGRLAENGSIVNKVAVWLRRRRGTIVVLTGHPLSSTAERSGERFRAGAGADRRGICPEQLGLVAGAPASFLVGRGRIVWRTRSVPDHPREVEYQFGSRRAIKILSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQR9</accession>
    <name>A0A317WQR9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">EFM7</name>
        <name evidence="7" type="ORF">BO94DRAFT_85493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQR9"/>
    <dbReference type="STRING" id="1450535.A0A317WQR9"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY86520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="258" mass="29052" checksum="8CA4DFBD0B4643CB" modified="2018-10-10" version="1">MAEEDTFDTGDMFQDPEGFYEPEPEPTFAEHHMLNGQTVRVRLVGSHPLYGNLLWNAGRTSSHYIEERASTLIEGKDVLEIGAAAGVPSIVTAILGARTAVMTDYPDPDLVENMRYNASLATPQIANPSALHVDGYKWGNPVEPLFACLPAGATGFDVLIMADVVYSHREHPNLIKTMRETLKRSKDSMALVIFTPYEPWLLPKTEKFFPLAEENGFRVTKIFEKLMDAVLFENDPGDERLRRTVFGYEIRWADEELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQV8</accession>
    <name>A0A317WQV8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_515846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468191.1">
        <property type="nucleotide sequence ID" value="XM_025609939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQV8"/>
    <dbReference type="GeneID" id="37112082"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="565" mass="61004" checksum="7EA67B0C490ADCB9" modified="2018-10-10" version="1">MSLVQTFHYEVTAPPPSLSHPAIPSPLHSIPPTPADDTPDPLNTPLRQNLAPTAGQAVFERAPSVQITQSRRLAITVLLLLANLVQMTVSFSGMAGGTRLGESLGAKATSATWVGASYGLTQGTFVLMSGRLGDVFGHRELLLLGGAWLSLCTLISAFCNNFVAFVAMRALAGLGGALIMPNAVAMITSTNPPGRVRNLSLGFFAASAPTGGYFGALFLGAFMEKTEWKWFFVFIAAIGVAIFLPLWILSSREPLLDKHGKIDWIGSALGTSSLILFNFVWNQAPSVGWSTPYEIALLITSIILFGAFLLWEKTGTDHPIMPLEIFQAPSILTLLLVVLLNYMAVGTLIWYQILWLQDIWHWSTLHFAISWTPFVICATGAACLAAWLIPRLAAQWILAIGTTTILVSNALMATVPLHQTYWAQVFPSIILFSFCPDFVYTAAQIIASNSVRRNQQGIAGSLIGSLNLYGVSLGLGFSSTIEDQIAQRSGSRIEGYRAALYFGVGISVVALLLDVCFVRMVKDEREGWREEDRALADADADADALEMTGHAAATGAEWPVPAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WR07</accession>
    <name>A0A317WR07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">gluconokinase</fullName>
            <ecNumber evidence="3">2.7.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Gluconate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_515917</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468241.1">
        <property type="nucleotide sequence ID" value="XM_025609942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WR07"/>
    <dbReference type="STRING" id="1450535.A0A317WR07"/>
    <dbReference type="GeneID" id="37112085"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="13">
        <location>
            <begin position="559"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY88879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1235" mass="136301" checksum="B9E0BFA8659FF969" modified="2018-10-10" version="1">MVLSPTPSLPSTSTPPSVPSPATSVTEPEAEVAEETLHTINDLLQSRAKGHHGNEPLVAYPTSGTDYIYYTPRQLDTFVEAASVHYAKAIPQRRLAEDPVQVVGLLGPSDFEYLITLLAVSRLGHTVLLLSTRIAEDAYISLVESTKATFLITHSSFQTMGDTVAGRTGITQQPLLTREDYDVPPADSVSLSSAHLDGAIEAKHICWIIHSSGSTGHPKPIHQTHSGALKNYANNFGLRGFITLPLFHAHGISCLFRAMHSQKLIYMYSANLPLTAPNLLSTLEEHPEIDILYAVPYALKLLSESDEGLQMMARLELVMFGGSACPKPIGDKLVQNGVRLVSHYGTTETGQLMTSFRERDDLDWDYVRPSPSVLPYLSWEEQMPGIYELCVLKGWPSKVASNRPDNSYATKDLFEKHPTKANAWRYYARLDDTLVLENGEKANPLVIEGVARNDPNVAEAIAFGANKPRLGLFLVPATSSQCETDEQLIETIFPAIELCNAELPAYAYISRDMIHVLPPDAVYRKTDKGTVIRSAFYRDYQEQIDQIYDAEDASGDQVLEGAGLVSFLREQLLAVAPAIDPSTLEETTDVFSLGMDSLQSIRLRTAIIRTLDIGGNKLSQNFVFEHPSLQAMAEALTRLRLGQGPTEQIAVEERMASLIEKYSTDFKTHVPVPREGDGEHIVVTGATGSLGAHVVAQLAQLENVKTIYCLVRADSRESAFRRVHQSLRTRKLSYSLTPATQRKIVALPADLSNPTRLGMDESIYAHLMHSITAVMHCAWSVNFNWSLESFEGSCIAGTRHLLDLCLDIHAPHPARFSFCSSVSTVARTPGQWVPEALPDTLACAQRMGYAQSKLVTEHIVNRAAQHTGMTARVLRVGQIIADTARGIWNATEAIPMIFQTAETIHALPQLDDILSWTPVDMIATSVIDLTLAPVAGAVMNVSNPTLDHWTRDLLPLLRQAGLEFEELPQREWLQRLRDSNADPDTNPPIKLLEFFTSKYDHDLPSRALLYDTKQAVSAAPALREAGGLTPELVTKFIDFFRTQCWTTTSSSQSPQQVIFLTGPCGSGKTTLSQALARQFPLSVIKGDDLHSPASREKMSHGIPLQDKDRWAWLAHIRGAVMDRLQHSDSTTRGVAVTCSTLRTVYRDELRRLADLLDFPVTVTFLLLVVRDREELKGRMVGREGHYMPEGMVDSQVDLLEEPLMSEGDVITLDAGGDMAGVLEEVEGFVGEILRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRH7</accession>
    <name>A0A317WRH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TGF beta receptor associated protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_623709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467977.1">
        <property type="nucleotide sequence ID" value="XM_025617169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRH7"/>
    <dbReference type="STRING" id="1450535.A0A317WRH7"/>
    <dbReference type="GeneID" id="37119312"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="43"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="234"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1208" mass="134307" checksum="6E819A2EA0D2A12A" modified="2018-10-10" version="1">MVSEEEGVSPRKRRKIGPPKAAPYVFRSLFDQVPLNADNDDDDVHITWVEYWNDNLYIGTSAAEILHFVCLPPDPSDKSNEPSFILASRLPIPFSQTSSAKLPGIQQIVLLPTVNKACVLCNGTATFYMLPELSPAFGNTKVSSCRWIGGLDLNAAEEFESPVVMIAASNRIMLVRIGDDARRIRNIEFPGCLVASRRGPIACAADTHAYSLLDVENQQKIQLFPVSFSSEMSEAGQMEARSPSSPFASSPVAENHAHDRSFGPNTFAGMLQPKSQPTPHDRSTSVTPELSPVSGTPRRSISKDRAESASPRISPAHSARDSQPSPDDRKPLPAVPKQPPTQLKPHVLSPTPSEFLLVRGTDATEPGVGMFVNVDGDVVRGTITFHKYPESIVIDKGDENHMIPSPENTHEELLLAVIESETDGQPRKFLEVQLWDVDPAEAEDHKTWVEIPSTHDTQPTPVGLCHTLSPSKLEISELGDLLRMVRLKTPLLSPHVPAHDPRTQASIEQLQKEKELSEAQVTDSDGSKKGEHGWEVERNAEEARFARELGQTQSSMVMWNGNQIWRVVRNPLTTQLNDALQNAQEAGTGDSRAFNRNAIADIIHHVQTTEPKSESEFLGLNYVKQKASLLLFADLVFMDPAVRKTTIIDDTERALIVGNLDPRIALLLVPLLRREVLQGPQGIWVHAGLAEITEAYVQQLEKTTDSSISDSAVLDMLKRFLFSWQQKRGYGSITDETYVFDSVDAAILHLILEQDAQMSAEQRSHSSIRAELNRLVDNWKGNFDRAVALLESYRRLFVLSRLYQSQKMSRNVLKTWRRIIEGEEDRGGEVTIAGTEAQMRRYLVKIKDVQLVEEYGAWLAQRNPTLGIQVFSDGTSRVKLETLDVVRLLKEHAPNAVQAYLEHLVFVRNHTQYADDLLSYYLDTVLSVLESSPEARASLAESYSTYRALQPPKPTYMNFITENTPAEPWWQSRLRLLQLLGGGSGGHFSSLPSRNLTYSIPAVLARIEPFQKELVSESVILDGLQGRHREALHLLTHGLGDYDSAVRYCLFGGPRSTSSTGALAEFADRTLQSELFRYLLDEFLHIQDPSERIERTSDLLGRFAAWFDVGEVLRVVPDDWSVDILSGFLGHVFRVLISEGREVRIERALSAGLNLRIGTEYIAGVEKVGGWVEDEGGLRRLKEGAAKAEEAKDLGSDFGDMVGADAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSP3</accession>
    <name>A0A317WSP3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_565775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467691.1">
        <property type="nucleotide sequence ID" value="XM_025614512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSP3"/>
    <dbReference type="STRING" id="1450535.A0A317WSP3"/>
    <dbReference type="GeneID" id="37116655"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY87908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="307" mass="34494" checksum="C8D99E20CE927CF9" modified="2018-10-10" version="1">MSLRIGQVIYGKRASYQVMEPLKSPTVFKAKILSGSEINQEWAVIKTAIGDLERAALRREYNTYQINAFSSNRYIRTMYEAIGPIETSNLDASSHLVFEYMDTVLRKVPSDKVRGTTLPRNISQSVLSALEVMRSQRRVHTDVNINNVLISDLNGDSPVVKLGDLGMVMQDGFDEQRLQSLPSRAPEVWQGHGCFHSSDVWSVGVMLAQWASWRYIFGARDKIIEEYPEAYCIAKLMALIGPLGDPTDQYAPNFELAEQLLSMDFGPEFGKVIKVGNLRDELRSVANPPVPTELVDFIIYLLTADPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWB5</accession>
    <name>A0A317WWB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_574332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469001.1">
        <property type="nucleotide sequence ID" value="XM_025615013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWB5"/>
    <dbReference type="GeneID" id="37117156"/>
    <dbReference type="OrthoDB" id="10616173at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="186" mass="19334" checksum="053821C31BCE528F" modified="2018-10-10" version="1">MSGHAFQGPGYKIPHDLATPHSLYLTQYPQTNSSRTTSALLFHLPSSHLSTWVSSTTTTNTVTSTALAAMVVPRAVPAVPAVLTVVVPVALVVPVALVALVVLTAVLAVTVVTRKALEDMAALTAVVPVVLAVLAVLTAAALVALVALTEALAVGKSLTDRKSSSADDRTFKLLERVTVALIPRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWY3</accession>
    <name>A0A317WWY3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_584422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468789.1">
        <property type="nucleotide sequence ID" value="XM_025615626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWY3"/>
    <dbReference type="GeneID" id="37117769"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY90411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32263" checksum="A559E882C1DBCF34" modified="2018-10-10" version="1">MTTAYYAYTPSAIPAIIGVGIYCTLAAVHSLRVISTKAWDGSFMIFGSFFQAMGCGARILSSHNKYEKGAWAAQYVLLIWGPALVMFTVNLTSVEFTKAIGAEKKVLIKPRIARPLYFTINTILFLLLSIGVVMKVTAATEKLQMGTTLTKAGLIIQLLFWLFTFIENLVMTIRLGRDPSKESLEVVPQWKRWNQLLGLATSIIAMGHNVVQLTQMGMASDGFMNATEWPAYAFDIYQLAVVLGAWGIWYLPGRCQAVVPKRKGNWGLMASEYQLTESRNVDYPDTRYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYV3</accession>
    <name>A0A317WYV3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA(Phe) 7-[(3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4)]-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_545249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TYW3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468890.1">
        <property type="nucleotide sequence ID" value="XM_025613225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYV3"/>
    <dbReference type="STRING" id="1450535.A0A317WYV3"/>
    <dbReference type="GeneID" id="37115368"/>
    <dbReference type="OrthoDB" id="263283at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48418:SF1">
        <property type="entry name" value="TRNA WYBUTOSINE-SYNTHESIZING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="10">
        <location>
            <begin position="16"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY90512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="328" mass="36704" checksum="8EF29C299C046E37" modified="2018-10-10" version="1">MDTSDKTMIPEVFESRKRKILAELSIPDAEYTDLSPKGSVDEGIRVLINDINTLPGLVTTSSCAGRISVFLEGRKKQHQVLSDEQQRQFVPSGGKGAGKWLYVSHEPLKENGKMQDKERQRLHELFGMIPGDGRPPGLNKNGQAPRLVRFSFEPMILHIMTATLHHAHPVLSAASTSGFRESGLQSLRCLEADDNDGPSPIVAVRSAGLSLESVIGYCEENDDDYQEPVIHSLVTEEFLEMLVAISNERFSVNCERKERFRANLLDLCSIGRSHGTKTKGKAKPPGWEDPEKRKERMRAEGLLRKQLMEDQKKELDIDFDLSVPGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZQ1</accession>
    <name>A0A317WZQ1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 15">Catalase</fullName>
            <ecNumber evidence="12 15">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_489260</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12 15">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="12 15"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469233.1">
        <property type="nucleotide sequence ID" value="XM_025609083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZQ1"/>
    <dbReference type="STRING" id="1450535.A0A317WZQ1"/>
    <dbReference type="GeneID" id="37111226"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000050">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12 15" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 14" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 12 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="18">
        <location>
            <begin position="43"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY91505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="748" mass="84109" checksum="FFBDCE1F75AC1DCA" modified="2018-10-10" version="1">MATVVAEGLEKAHEAVKSAASKNKKSVDLERDMVDVTTNQRQTTDHGVPISNTDQWLRSVDDRRTGPSLLEDQIAREKIHRFDHERIPERVVHARGTGAFGNFKLLESCEDVTYAGVLTDTSRNTPVFVRFSTVQGSKGSADTVRDVRGFATKFYTDEGIWDLVGNNIPVFFIQDAIKFTDFVHAVKPEPHNEVPQAQTAHNNFWDFCYLHPEATHMFMWAMSDRAIPRSYRMMQGFGVNTFSLINKEGKRHFVKFIWTPHLGVHSFVWDEALKLAGQDPDFHRKDLMEAIDNGAFPKWDLSIQTIPEEKQDDFDFDILDATKIWPEDLVPPRTIGVLELNRNVDEFFPQTEQVAFCTSHIVPGLDFSDDPLLQGRNFSYFDTQISRLGVNWEELPINRSVCPVLNHNRDGAMRHRITKGTVNYWPNRFEAAKPDDPAPQGGGFESYPEPVTGRKKRALGPKFREHHSQAQLFFNSMSEHEKLHMIKAFSFELDHCDDPIVYERLAGRRLAEIDLALAQKVAEAVGAPIPEKALMANHGRQTIHLSQTEFPPKSPTIASRRIAIVIGDGYDPVAFKGIQTAVKAAGALPFVIGTKRSPIYADGESKETSKGVIADHQYDGQRSTMFDATFIPGGPHVKTLRQIGQLRYWIAETFGHLKPLAGTGEAAELIKEALGSVLDVHVATASNPQPVDWYGVVTAGGIQKPESFQESVQIIKDAKDFVGMFFYQIAQHRNYKRELDGLSSTVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZY4</accession>
    <name>A0A317WZY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_461507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469682.1">
        <property type="nucleotide sequence ID" value="XM_025607934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZY4"/>
    <dbReference type="GeneID" id="37110077"/>
    <dbReference type="OrthoDB" id="5360255at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004354">
        <property type="entry name" value="Meiotic_Rec114"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03525">
        <property type="entry name" value="Meiotic_rec114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="226" mass="24644" checksum="BE582054A3CBCCEE" modified="2018-10-10" version="1">MNPLSQQPPDSTTLARLSLAKFSHTTTSLNHRGPLHWSHVMGNGNLIGIFEKRAMTSFTPDRVLLKVLGVHETLEEIDLTHFAIESGNITHFSQSAASKPIFAVVVKLPCLAVKYPRGNMVHRFQIKFSFDRDFYTALAILSDMKCPFSEASVGSMRKLTSSQWNSGSIECGSIAREPTYGLGMPGSSASHPVTLFQHPSTTSTSGSSSSVTAGKYPRLPMTDIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X311</accession>
    <name>A0A317X311_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Checkpoint protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_533324</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469615.1">
        <property type="nucleotide sequence ID" value="XM_025611306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X311"/>
    <dbReference type="STRING" id="1450535.A0A317X311"/>
    <dbReference type="GeneID" id="37113449"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13981">
        <property type="entry name" value="STKc_Bub1_BubR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000003">
        <property type="entry name" value="Checkpoint serine/threonine-protein kinase BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012572">
        <property type="entry name" value="Mad3/Bub1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08171">
        <property type="entry name" value="Mad3_BUB1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="7">
        <location>
            <begin position="64"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="821"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="522"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="846"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="244"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY91887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1207" mass="135963" checksum="8CF397ABD3779568" modified="2018-10-10" version="1">MAAPGDLINFDIIEGQKENIQSLPGGRSARELARIFSPRDSTDILATPSPNDTRTVNDAIRQEYEAELQAIGESDDPLDIYDRYVKWTLNAYPSAQATSESGLLPLLERAVKSFLTSPHYKNDPRYLRLWLHYIRLFSDSPRETFAFLARHDVGEGLALFYEEFAGWLESAGRWTQADEVYRLGIDKEARPAERLVRKYSEFQHRYENHTQDNGPSSPALPAVRPALAAKVDPFASASPPATEAQRPAPARGAAPKTKSGKPKMAIFSDADSPSQPAVSGPAQGWDNIGSLHERRKENKVEAKPWAGETLKAGKKPAPAQKMAIFRDESNSSSQAKEALQNKHVPEHRVREAINPRTGRRERVFVNLEAVYPDYKNPNHEVSFEELRAMSRGWMDKNWRAQKEPLKQISGNATSADLPSDNPLEQGLENELPEQFKQKLTVRDADTHDQGQAQVAQESKANKARKLKLREVKGETQTIKMKFDSPTGGKIRRKSTAEPTMTIHTRAATDEIYSIFNQPLKAETENVAESSDFEDDDYTSAGESTGTGRHSAASSDFGDDDTTFHKSFVEGDEDGFGDNTRAESVVDGEWTQFSACDVPAHSPDMPGDSTYHDREDNTGQFLDDADETERQRFVPEMPEDYNPPYGPYRDPAVVAQNRLPFMTPIVEQTEYSLSMTAARNSLYNAKTPSKPQMGNLLLSSPFIPATPRNFPDIPEDVALSPTMEKVRTGFKLSPLKDSSRRDVVIKDAQCNPTDREIRDTILQSLQPPLACYPGYHGHSEMDTHYSSEVQRFLKTSPKRSRSGDEASFDVPILELPGAERSYIIRRELGAGAYAPVYFVESIDNIPSDSDAESMDGNSRDSHNRKMTQYDTPRYGFEAIKLEVGPPNAWEFYMIRTANDRLSRHPEFSRAAESLIRAHELHVYKGENILVEDYRGQGTLLDLVNLIRNEPISAGTNGEGGMDEVLAMFFTVELFRTIEALHTCGVLHGDIKADNCLVRFDDKPASPPSLIDLGDEATADPREVHYSPRGLYGWRSKGLSLIDFGRSIDMEAFQPSVQFIADWKIGKHECNEIREKRPWTHQIDLYGLAGTVHVMLFGKYIESVPSGPSTYRIRESFKRYWERDIWTDVFDLLLNPGEERWAQMEREGNNPAAMASDNPTILPVTNSMRYVRERMEEWLFLNAEKKGLGLQIRKLEAIFAERKKRLEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X368</accession>
    <name>A0A317X368_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Efflux pump antibiotic resistance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469764.1">
        <property type="nucleotide sequence ID" value="XM_025611198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X368"/>
    <dbReference type="STRING" id="1450535.A0A317X368"/>
    <dbReference type="GeneID" id="37113341"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27471" checksum="F7D3FCA3FECB1421" modified="2018-10-10" version="1">MCNALETLGLPCWHSTQFMSSKFGDIEMWQEAVNRKFFNAPGPKYGRAEFDQLLHDYGAVSSDTPAIAFADDLIQAYPDAKVVLVERDIDSWYESWMNSVIKNTYNPFVTVVYTLDRWFTHPLGHVHKSTFDGWLGIKGPEDAKRVSKAKYREHYALVRRLTPPDRLLEFKMSDGWGPLCEFLGKPVPEVPFPHLNEKKWLDEKVQIVMHRGMRRVVKKVVLWILAPLVLAAMVYKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3Z8</accession>
    <name>A0A317X3Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_544311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470047.1">
        <property type="nucleotide sequence ID" value="XM_025613173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3Z8"/>
    <dbReference type="GeneID" id="37115316"/>
    <dbReference type="OrthoDB" id="10509622at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="117"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="335" mass="38482" checksum="8FA7215DBBECD0AE" modified="2018-10-10" version="1">MENRDPRRGIVQRIMEDTQQAMQLSNQAMQLSNQAMQHTQQAMKSSNQAMQHMQQAMHRMLRLILYTEGGPPPSMPGIREMISQAAVPPVATEIAPAGDASFIGTIGKVVQAMDRLASRTARQEPAQISSTIPETQQPQEGYDHGQQSEGVAGQENHPPPRTSTPAPRDPWSQTPTAEWFTPIEDRPKSIAGDMEITTVCTRCFNMWMKRIRTQDDIPDCVFDRAKRKKCEYCSRQRNTCTPINPQLTQRLLRYKQRMEDPERPIDEAGNDWEEFKKQYVRVRTLLAREPIAQEEEFKQRDRARRARRREELKSRRPVEQQSTLSEDVSLSPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X484</accession>
    <name>A0A317X484_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_615691</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469762.1">
        <property type="nucleotide sequence ID" value="XM_025616766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X484"/>
    <dbReference type="GeneID" id="37118909"/>
    <dbReference type="OrthoDB" id="4468602at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="18791" checksum="B951540B33908456" modified="2018-10-10" version="1">MNNEPTTKQEFLMPLLYFVQRIQRYCPHFLSLSASIYEVPSDDEAMEIVTDNYSPEASLEWNSEAIDLAEFRKFVQEWRSRYTFLDFEFHEAVVTPDVDDVEGRGGTLGFGLKGRVLGKDDGKMYEGKVHAIFKVEWINDRRVITRNQQILQGPYVVKDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4D3</accession>
    <name>A0A317X4D3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_563841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470187.1">
        <property type="nucleotide sequence ID" value="XM_025614379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4D3"/>
    <dbReference type="STRING" id="1450535.A0A317X4D3"/>
    <dbReference type="GeneID" id="37116522"/>
    <dbReference type="OrthoDB" id="2922289at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788:SF2">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40788">
        <property type="entry name" value="CLR5 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="699" mass="81390" checksum="6532FBEB091467E5" modified="2018-10-10" version="1">MKRLEGTVRKRWLKRTREQRKNLLLSAWPNMAALHRPDIEAFRREPPGNPEYREAYMWPHVNLEDLLNPKLLLIFLNARGRHPPHAFIQADWASVDFGRATTNIIRALMENHVMIFTGRTTPDTYGEFVQCDNDRAFEPESGREMNPGDGLLSLEIQERLYRFLVDCCMLLLPEYTRESILQADIPIQPEPPVITTSESGLDLLSVVAAEAPYRLPARLDIDRLHSIVAAKKSAAEDHIWALREDPGYFLEALLERKEHRPELVPDARGQLHPSTKPFAIKKLWNNIISGVVSDAYFQLGLWAEINDQLEVIERLMTKHAAVIRPENDLPRALEWRFMKLIWLLERMVRGPIINLKMGFPPSPPIRSFFLRAPPQYGQDNIRTMPKDSWVADKKRSRLSWIMTTLWDEKDRPLAGLTNLTDELQRLIENDKYIRDRHVDQWSQFEKSMDGDFFGEFCDPTDGRFNYPVDKRRTKETTIQMQQAEAALDEFWKQVDLRLVNKKNMSQHATVRGLLSQSHIRTRTPDWVEPAKDADLDVPEESNLPISVLYYELDKRTQRTLDVEKLEPAREKVKTRGTASRGADDIEEPSHGPDIQPTFTVDKRAYKVFTTLFYVPSRTSQPGEIPWTDFLHAMVSTGFRVEKLYGSIWQFSPQRLDVERSIQFHEPHPSGKILFRTARRHGRRLFRAYGWHSGMFKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4D8</accession>
    <name>A0A317X4D8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_544806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469148.1">
        <property type="nucleotide sequence ID" value="XM_025613199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4D8"/>
    <dbReference type="GeneID" id="37115342"/>
    <dbReference type="OrthoDB" id="4511136at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY91420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="224" mass="23474" checksum="04ACFAF400BA4BEF" modified="2018-10-10" version="1">MPFSDLYTAIDPMIPSQFPTSRSPTPTPAPGPSATIKSSVQSSLFYTNPPKQAEPEPEPEPAPTTETPSFPGNDCEESTHGSWPRSTTSSHSSALSHTPNPTALHSFGNKISATVTAHPILATFLFVQVLFSGIPVCMFVVGALVSAVFAVAVFSCFAMLVLGPVVVGTTLVAVGVWGSGWVVYKVGGWAVRRFLIAEVNDEVEGIAEGGRVGMWHGEGVGGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X510</accession>
    <name>A0A317X510_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_486462</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470166.1">
        <property type="nucleotide sequence ID" value="XM_025609005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X510"/>
    <dbReference type="STRING" id="1450535.A0A317X510"/>
    <dbReference type="GeneID" id="37111148"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="245" mass="27156" checksum="A92C60969966601B" modified="2018-10-10" version="1">MEQLYEKYPSLRKFENDDYQESHDGREVALLKHIYSHPSLPQIRDSPSTLLDLMDEYAAKQDFLISIGPDKAEKIAKLVADEKSKVIVELGGYLGYSAILFADAMRQAASGTSTELRVWSFEADPLIASIAMNFIDLVGLSDIVKVVVGPAADSLKRLSAEGKLPKVDLLFLDHVEDLYKTDLEVAEQLGFLHSGALVLADNVVRPGAPAYREYVRGSPKYESWGLKSLIIPGEAEDEIEVSRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7R2</accession>
    <name>A0A317X7R2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VIT-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_457694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471417.1">
        <property type="nucleotide sequence ID" value="XM_025607758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7R2"/>
    <dbReference type="STRING" id="1450535.A0A317X7R2"/>
    <dbReference type="GeneID" id="37109901"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF6">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="2">
        <location>
            <begin position="6"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="1">
        <location>
            <begin position="287"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="72941" checksum="344058BCE8902293" modified="2018-10-10" version="1" fragment="single">MAFHFGCCYLLPESGSWRYLPQVALQVHATLLSITSRTTVTQTFTNPASETIKEVSYRFPLYDGVTIVAFQCQVGDRLLCSEVRTKQQANEDYQTAVSQDRSAAILDQSSQQTDVFQLRLGNVAPYATVTVDITFVRDLKSDAQTDGIRYTLPNAIAPRYGMTAGEAPSLHTKHVERQGLVITVDIAMEKASVIREVRSPSHPINVAFGRISSTPEASNSFDHNHASASLHIVQGSPLLDQDFVLVIKADETDMPRALLELHPTIPDQRALMATLVPKFGLPAALPEVVFVVDRSGSMTFNITTLQLALRVFLKSLPVGIPFNICSFGSDYSFLWKRSRAFDASTLPEALALVDSMAADMGGTELTQAVEAVVRNRLDDQNLDVLVLTDGQISEQQALFDFIRNTAADHTARFFSLGLGHDASHSLVEGIAREGDGFAQSILAAELDRTVVRMLKGALSPHIYDYALDVEYDANSADEFEMVDCEPETKIDQVPVTASQNSHDTSSCTISLFDKSFQEPESDISGIGDSHIPSIRTPATIQAPQRLPTLYPFIRATVYLLLQSPRVPKSLTLHATSKHGQLQLRIPIEDVGLGKTIHQLAAKRAIGELEEEHGWLVGATDCKNTSYRTWSPSMKSTIAIRECQRLGLKFQVPGCHCSFVALEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7R3</accession>
    <name>A0A317X7R3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_554042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471002.1">
        <property type="nucleotide sequence ID" value="XM_025613691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7R3"/>
    <dbReference type="STRING" id="1450535.A0A317X7R3"/>
    <dbReference type="GeneID" id="37115834"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="42"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="368" mass="41873" checksum="CBE1EF6E572579A6" modified="2018-10-10" version="1">MNNHSSPYRHTDLLYTQESFARYQPGGYHPVSLGDTFKDGRYEVHHKLGWGGYSTVWLVRDLERQDQWASLKIMAADRSVESCELNNLRRLEKHSQGSLSSKYIVQFLDTSFHQGPNGPEERLGTETILRISKQLLEGIAFIHDAGMGHGDISGANIAFSGSRLSKASKEEIFEVLGTPEIDRLSRTDGQPLEKGVPRHLVKVANWMEWIDEDDEDIRILDLGEKPIKLAQPGPLRVPETIFTECFDYKVDLWRAGCMLYMFIFKTYPFHYWGKMSACSAQMIGFIEKLPIEWQPVWQHMRSDSKFAMQVDETCNASKLDEIFYTNVSDPALAPLLPVIKGLLRFMPSDRMEASKALDLLQSMTSGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X805</accession>
    <name>A0A317X805_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_553616</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471494.1">
        <property type="nucleotide sequence ID" value="XM_025613671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X805"/>
    <dbReference type="STRING" id="1450535.A0A317X805"/>
    <dbReference type="GeneID" id="37115814"/>
    <dbReference type="OrthoDB" id="497541at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY94733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="886" mass="100574" checksum="34D40D30F547105E" modified="2018-10-10" version="1">MAPARRKGEASAGSQGPAPTPHTKQRPPPSPFYLPLNITLYLCVITNGIAALYAPIQDCDEVFNFWEPTHYLGHGYGLQTWEYSPVYSIRSWLYVSTHAMIGKIGSFALSSKSSEFYVIRLFLAMVCAACETRLYSAICRTLSPRIGLLFLMIVAFSPGMFHASTAFLPSSFTMYMSMLGLTAFLDWRGGQKTAQGIMWFGLGAIVGWPFAGALVIPLLLEEVLIGFFSSNVRGVFLGVLNGAIRCLVILAMEVAVDYAFLRRLVVVPWNIVAYNIFGGEGRGPEIFGTEPWTFYIRNLVLNFNIWFAFAMAAAPLLALQALFRPRATSVQTLLRTVTLITPFYMWFAIFTAQPHKEERFMYPAYPFLALNAAISFHMVLSFIGSSNPQDLVGRVSPKIKLAVVMSVVLVALNAGLLRIAGMISAYNAPLKVFAPLEQPGVAQPGDSVCFGKEWYRFPSSFFLPNDMRAKFVRSEFQGLLPGEFPEAAGFSALFEGTSQIPTGMNDRNEEDPGKYVDISQCSFLVDSEFPSREATELEPAYLHKDAQWEKLACHSFLDAWQTEWIPSDFKRPPASPYPNWDVHTTKPIPYRPFRYGPKYFVTMGLRSMKWDEWIELDNHYLRYHADKARRIQERGDKCCRTAPEAMDAAIELLEELTTYLPERYPSMFLKTPTGITNLITHETFNITQRPLPEDPMTICARLVQDDLAIMLEKPDGEYYLLAGAVLLAGFWRLEDKYQMRLSEIHTSGSVPQYKEKLEKGMMNFFRRLKPEDPVLRNNYFIQVDDNLAWSHSIGSEDSEDVSWSTAEKNKAINHHYFRSERQSLRRLPKTGAVVFTIRTYFEPVTAIADEDYVPGRWGDDEKYEEHEEQVMRGLDVEGEEVRKYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X824</accession>
    <name>A0A317X824_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_352675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470553.1">
        <property type="nucleotide sequence ID" value="XM_025607116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X824"/>
    <dbReference type="GeneID" id="37109259"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="74" mass="8761" checksum="7C7CA36357E42660" modified="2018-10-10" version="1">MGVWLYKERWSVGGVVPLRLTTRLCKFPVKYNQRLCSCLWVVFVPEALRAGLVLLGWGWDVWWRMIVVNGFTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X892</accession>
    <name>A0A317X892_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_285278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471574.1">
        <property type="nucleotide sequence ID" value="XM_025606662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X892"/>
    <dbReference type="STRING" id="1450535.A0A317X892"/>
    <dbReference type="GeneID" id="37108805"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01709">
        <property type="entry name" value="RT_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="102551" checksum="3786298BFCB56E7F" modified="2018-10-10" version="1">MLSGGALPQTLGSITATKIKEFAKQRALFEEQRVEIVKAAEDAPSLRSKAQILLEGVTKLKGFPNDALDQDDLSIDNSADEDSTIMDCTDRATHANIRRFLLQSKYDPSVSDRSLKGWIAQLEEELRYLELRHKHADFYSNLVTEWLADFEGGAASSATLDEDGPQDMEFEKGGSAEMQEQRATWESLVFKEEDVDADAIRAYLDGLFKATTPSEEALKELREKTRTFGNDLASKKTWFKVSDLEWVSDSLLKSDLLTKEKTAVLKEFMRNPAVAQEVADVLNMRLSSLDNWDWPAEGIPVEMRRQLNGKFRVYMDEDLLDSLMLEYLGVKWSVTLQSAFSSFLHTPAWKFLRERISRPEMSRRSRFTAEENPRGGIKCVNDHRKDTYIRDYFMTLLPCSVNEGMRSYDDDDETPDTTKKNPLATKHSLLHLLITESLVYTSLHGQFTALRSDFEWFGPSLAHTTILTVLDYFGVPQTWLDFFDTFLKTPITFRQDGSAAPQQVRKRGVPMSHALSSCFGEAVLFCMDFAVNQGTDGAYLYRLHDDFWFWGHEETCVKAWTTTTEFTKVMGLRLNGQKTGTVRLGKGAKTHEGQPDPLPKGDIRWGFLKLDPVVGQFIIDQDYVDSHISELQRQLASCKSVFSWVQAWNGYFGRFFANYFAKPAMCFGRDHIDMAVSTLTRIERTLFPNSSSGVTDHLRKVIADRFGVDDLPEGFFYFPVEFGGLELLNPYIPFLAMRENIRSTPRSRLQKAFSQHEVEYHAAMQRFEEGGLSEPAGTDDDMAHLSLEEYTRYSETYSRPLLAAYQDLTRVPEEIHVNQTVELRRHQMSLDETVANETAARKAISNEWYSMTAYWQWTAELYQGEMVKTYGNLAAVNRESMPLGVIKTLKEGKFRWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8E1</accession>
    <name>A0A317X8E1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_509704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471637.1">
        <property type="nucleotide sequence ID" value="XM_025609711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8E1"/>
    <dbReference type="GeneID" id="37111854"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24459" checksum="271A84C0B64A2ACA" modified="2018-10-10" version="1">MAPKRSRDETTDEKRTTTTTDAPVKKRKGFSVGPANLPDGTYRRKDLQTIAQKIKSDLIQKAKVRKAYAKVRAAELAAAPSKPRYTAEDGDDADKEDRTPQPEPASLELHPARQAMLDQPAPEPEPTPRPQRADRRDAKGRRERKPKPSAFSKEMEIAEKRRQEAEKRKEAREFRQKDREAMARARRPDQQGKRRLGRESKVLLSRVERMVGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8I9</accession>
    <name>A0A317X8I9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">C2H2 type zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_530809</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471675.1">
        <property type="nucleotide sequence ID" value="XM_025610756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8I9"/>
    <dbReference type="STRING" id="1450535.A0A317X8I9"/>
    <dbReference type="GeneID" id="37112899"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:003641">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF14">
        <property type="entry name" value="C2H2 TYPE ZINC FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY94914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="733" mass="81427" checksum="DBA55E2FDB367D7C" modified="2018-10-10" version="1">MPQTTTPPTTTPTTTSAVKTLICRVCQKGFSKAEHLRRHERCHTGSKPFICKECRRPFARQDALTRHEKLHVRAANAKQAQVQQPSVHVHPQTTSLDALPWDAGRAPAPAVVSTSAPGQAWETSQAEQHPGLQHAASDLDFALIWPDSENLFQSIMSSDTTDQWQMPLGALPFPPVVQDVNGMNFGSPNSFDDRGSSIGTIPSGGSHQAVRDVTEMVTSSSSSVTAAIKATSITSVFLDECLHMFFVRFIPTFPVLHRATFVFRECTHPLLLNAMALGSLYLGPKDSVAKGEALWRLAHTAIATSWQSLITHRGPYDVCKGVQLLITALLGQIYGALSKNRVIRTTSQVFRPLGFLWARHCGMLDCDPYPMENIPFPNAPSTEKEYKWRTWAAREIQQRALLAYHILDGLVAQMSGDSASTRHVANPLHLPSSEAAFDAGNVDEWIAIMRTHKAEQPSFRLVFRSLFPPIGSFRPLDYQFSAFALRVVLEGLQSLVSDSDESDLAAVGVPGRSDVRRALAQVHETITMSIHLSAPERLEVLLRWHTICLDTMINSTVLCRHVCSRYEIAQHVSGGSRMIRSGFDMTKWVNTEDARRALLHAIAIQDIVEQLPRGRAHVIHMPSSLFSATTIYVVFSLAGVANIHLPRTIVWQDALLSRADLNLGCENIRPSNGSETRRFVEEGRTDSPPGMGAVRNLLYEMNSLQKLFRCMFSQWGIAHDMEEIIDQWITLCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8S0</accession>
    <name>A0A317X8S0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_562721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471774.1">
        <property type="nucleotide sequence ID" value="XM_025614312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8S0"/>
    <dbReference type="STRING" id="1450535.A0A317X8S0"/>
    <dbReference type="GeneID" id="37116455"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="325" mass="35929" checksum="1E057410F9FC8D12" modified="2018-10-10" version="1">MFSAVAARLVPRSNNLFDMQGKYVLVAGGSKGLGREICLALVERGAHVTAIARSYDALERIARDMEAAKVHEQQVLGIQSLDLTNSEEVSKFVNGFEKHISALFCTAGGTDEEVGYFADISATSIQSCMEKNYLTSAYITHAVMKVWKTDLELEGGRSHAQEPRHIVFTASTAALVAVPGYAAYSPSKAAIRALADTLRQESLMYSPSGSIRIHCSFPGTIYTDNFYREQTRKPDLCKELEGTMNDEGGLTARDVAQRILAGLDTGCYFIPTDLQTRLLLNNMRGPSPRDSPLLDWCMGLIISLVWPLIGTYWDWKVARHHQRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9G5</accession>
    <name>A0A317X9G5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitination network signaling protein acrB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_508125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471900.1">
        <property type="nucleotide sequence ID" value="XM_025609650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9G5"/>
    <dbReference type="STRING" id="1450535.A0A317X9G5"/>
    <dbReference type="GeneID" id="37111793"/>
    <dbReference type="OrthoDB" id="4158994at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="575"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="959"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="604"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="990"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1015" mass="109436" checksum="C3E36B04282423E5" modified="2018-10-10" version="1">MPRSSATARKSHSNRHENGIVGPGKKVNKQKSNGNLNGNSNGTSAPNTGPSTQVDWPASRSSSDSVLISTQATANKLNGTTETSKVDGNGRGLLNGYAKGNADMSYGQTNGAVPQNGALASQASRRTEKPATGSKRSSSINPLQLASTILKSCPMYDTIAILIFLLQLPPMVLTLVQFLFASLTFMPPSGASSGSLTSNFDIFQGPAGTPSLGTMIAMDGFCLLFWGLFMWTWAQNFALDLAHVQVAITLGGGGSGKNGGVNALCVGIVLVLHLIRSKGIQDFVLGHLLSAKIVSPDLLSQYSHLMPPEFRRTEPQSSPSWMRSLLAVHILAQAGTAMARRSMAKNRSPAPPRNGKRVDTEASAGSQTQIDSAFESGASVSSYIGADGQIVTPATHKDGRDRLISAKKRRRQANQVRSRQPFWAALASTKVTVMREYEHSRALNKTGRGLTMTEEDLQGISLDDGLVWITEVDSSTIKFAAGDFASLDDPAVSGVCETGRLGNEETEPFYVCVNGALWATATITKVQDAPKGSNTVHWRGEVSGLAPNCAYTCSFMRTDTDEEICVMSVKTPAATDAEQVSSVPTPPQPSYRPSSPTTTLKNSIVNAEVKLNEKRARLRKAKNDHKLVISKIKKELDNYNHRLQSGTDENRQKQRSLQLERNIKQTEEATAALESQLDNLENIPEEELEEWTSQKAKFDQELEQLNLAKEELVAARSAVAREVSSLESELNSAIQRKERLQGRRTRVNEQYERIVSANAQGLNERERRAAEQFAREQDQAKLEANFNDQFTSISHSVQDYQLRTNQLWQQAAAIEQAIQQQQQILLDSAPLTPEGNLPGTNSLTETSGMSLGSLTTTAPSTRSLLGLSFPALKSSPLQHASSPAGAISSRPASPIQVPYLQHFPTSPLGNTGTYFDTDFTYRDRSFSNRSARSSLYGADFLDSNRRGPFQLDLSDTVAEKRMDSGSEGVTPNPIMRPISTPFQRTDSRGSGSGSGSSGASGSGSGSPSSAGGKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9P9</accession>
    <name>A0A317X9P9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_532559</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470389.1">
        <property type="nucleotide sequence ID" value="XM_025611140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9P9"/>
    <dbReference type="STRING" id="1450535.A0A317X9P9"/>
    <dbReference type="GeneID" id="37113283"/>
    <dbReference type="OrthoDB" id="1697690at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY93628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="125" mass="13638" checksum="EF9E42EC97B19F85" modified="2018-10-10" version="1">MAAAIKAINAKIRSNKALDYFCSTHFWGPASNFGIPIAAVMDTQKDPEIISGQMTGALVIYSATFMRYALAVSPQNYLLFACHAVNFSAQLTQGYRYMNYWSWGGREAQLAEAAKQGKQATEAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9R1</accession>
    <name>A0A317X9R1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_214630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471702.1">
        <property type="nucleotide sequence ID" value="XM_025606177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9R1"/>
    <dbReference type="STRING" id="1450535.A0A317X9R1"/>
    <dbReference type="GeneID" id="37108320"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="57"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="376" mass="40866" checksum="370F923986709F90" modified="2018-10-10" version="1">MSFFIENPNVGDRCSLEDSRIRGYNPLTPPNLLQHEIALTDKSRQTVLEGRDEAIAIVQGTDTDRHRLLVVIGPCSIHDPEMALEYCDRLMKMKEKYQDELLIVMRSYLEKPRTTVGWKGLINDPDIDNSFKINKGLRTSRQLFVDLTNKGMPIASEMLDTITPQFLADCLSVGAVGARTTESQVHRELASGLSFPVGFKNGTDGSLDVAVDAIGSVKHPHHFLSVTKPGVAAIVGTVGNPDCFVILRGGKKGPNFDAQSIAEAKAKLTAKGMPARLMVDCSHGNSQKDHKNQPKVAAVLAEQIAAGETGIMGVMIESNINEGAQKVPAEGKAGLKYGVSITDACIHWEDTELVLENLAQAVRTRREKLAVNGNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9V4</accession>
    <name>A0A317X9V4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_563012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472154.1">
        <property type="nucleotide sequence ID" value="XM_025614326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9V4"/>
    <dbReference type="STRING" id="1450535.A0A317X9V4"/>
    <dbReference type="GeneID" id="37116469"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="337" mass="37858" checksum="949F1FCE9A50A444" modified="2018-10-10" version="1">MADHANDWLQGNLPWSHLPTVNKIDTHHHFSVEEAGGDPSGWPTPHWSSIRSELLMKRLGIQTAILSATAPGACILRGQPSYNLARQLNEHAAELRDKNPDKFGFFATLPDILDTDAALAEIHYAMDTLHADGVTLFTRYGFDHTYLGHPLIEPIWAELHRRKCVVFVHPTHPVDTTKVNSKMPQPVIDYPHETSRTAMDMILMGTRSKYPDCKVILSHAGGAFPYLISRLATPLRKAPGFASELTMGTTHEKVMENFRSFYYDLALSSSPQVLDMLLKIVPHDHVLYGSDFPYAPPPAYPAFLEDLEGYEMPPELRDKINFGNACKLIPRLARKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9W5</accession>
    <name>A0A317X9W5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_455958</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471772.1">
        <property type="nucleotide sequence ID" value="XM_025607682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9W5"/>
    <dbReference type="STRING" id="1450535.A0A317X9W5"/>
    <dbReference type="GeneID" id="37109825"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF1">
        <property type="entry name" value="ALKALINE PHYTOCERAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="283" mass="31301" checksum="ACCD25BC87E079BF" modified="2018-10-10" version="1">MDSHSSFWGATTSNANFCEEDYLVTRYIAEFINTLTNLVYVFYAIYGISYLRRKSNTDVSRVLPYWGLMGVGIASAAFHMNLKYHTQMMDDVSMLLTTTPVLHRVMTVNASRRTSVLVGVLLSLSLLGLVAVHVITDELILHSVAFVVSVTVIGVRTMQLITTRTPKDSAARRQVWGMVRFGAVIFELGFAVWLADGWICGLLRSTRHAIGLPWAFLLELHGWWHIFTGVGAYIFIAVVDHLLCSEDPEDIQGSFAWPAPWAAQSMFAGKGSSAGVKSGSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA72</accession>
    <name>A0A317XA72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_482054</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472264.1">
        <property type="nucleotide sequence ID" value="XM_025608878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA72"/>
    <dbReference type="STRING" id="1450535.A0A317XA72"/>
    <dbReference type="GeneID" id="37111021"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="818" mass="91876" checksum="893797F69F9835EF" modified="2018-10-10" version="1">MSFPSIESTSPVNAASAPSSLSPRNGSDVVPGPHTSLNAHVVSHSAQDSLRSCITCRRRKVRCNKKTPCSNCVKAGIQCIFPPPGRAPRKVKRPQDAELLSRLRRLEGVIEHLSEKKTSSAPPSSETPSPRLQQHSENPPAPPVQPQAPQHEGDGDGCPLLLDAAKLDPTRPIAQRNVEHEFGRLVIEESRSRYVSNRFWASLGDEIEELQDILDPSSSDEEDYPSPETSSSHSANHDGFLFGFYSASHSLHEFLPSKSQVPKLWNTWLDNVAPLIPIVHKASAQQIFTTAAQDPSSLDKNFEALFLAMCLVSIISLSPEQCSLRLGEERDVAVKRYRFAVEQALAKADLLNTQNITLLQALVVFLIGIRREDDTKFVWSMTALVLRLAQGLGLHRDGTNFGLKPFETEMRRRLWWHICLLDIRSAEDHGSDAQIHERLYDTRLPLNINDEDITPDMQEPPQEHVGWTEMTFCLIRCDITVAVRRVSYACPNGHFAAAARHLDPDNCARLIRSINNRIEDRYIKHCDMNIPIQWVCATIGRLILTKLWLVIHHPMTRPERGLKLSHANRESLFATSVEVVEFQRLLDGDVKTYKWSWLFATNMQWHAIAFVLSELCVRPLSPLTDRAWKAVSTLYTEWIKNSKQRKGMLWRPLSRLMKRATAFRAKQEEMQAQMSSNVCPVQDISPTGRHGLGLVPASILPRALALQPLPTSPINDTGTFPDNGGMDFDIRKGPIGIIEELFPETDWLNPATAASLQQPVNSGASMETLVRPTETETQPGMPNNLNWEEWDQVMTDFQMDLHATNTQNPFGNALDWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAF9</accession>
    <name>A0A317XAF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FabD/lysophospholipase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_572185</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471373.1">
        <property type="nucleotide sequence ID" value="XM_025614906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAF9"/>
    <dbReference type="STRING" id="1450535.A0A317XAF9"/>
    <dbReference type="GeneID" id="37117049"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="9"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="329" mass="36518" checksum="7949D8AA0F62E65F" modified="2018-10-10" version="1">MISRNVSLLSLDGGGVRGLSSLYILKHIMESIDPENTPKPCEYFDLIGGSGSGGLIAIMLGRLEMDIDQCINAYKRLSNHVFSRKRLLPVGGNLRRQSKYDGRRIETAMKAILHELGYEDDILLREPASSCRVYVCVTDDGSKRNLAPLTSYPSKYCSNELYKSAKVWQAGRACFSTAPLFDPVPIGPSGRRFYNSNTDANNPVREVWIEARGIWPSGSLDSQIRCMVSIGTGVPSIKRSGKAMFGLLKTSRADSIDTEMDMNKFLREHTELDDENRLFRFDVPNGLADIGLDGVDEIDTIVDATEEYLAKELVYKQIQKCGNALSEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAI3</accession>
    <name>A0A317XAI3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 88 putative glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_563499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470719.1">
        <property type="nucleotide sequence ID" value="XM_025614363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAI3"/>
    <dbReference type="STRING" id="1450535.A0A317XAI3"/>
    <dbReference type="GeneID" id="37116506"/>
    <dbReference type="OrthoDB" id="2305845at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="366" mass="41773" checksum="E8D0FEC357AFAF8E" modified="2018-10-10" version="1">MPSPTPIHSKINLLITNLINIKDTTGTFLLPLSDGRIIDTKSWDGWEWTHGIGLYGIWKYYEMTGSSHLLQIIEDWFAARFAEGGTTKNINTMAVFLTLAYVYEKTGNVTYLPWLDAWAEWAMYELPRTKYGGMQHVTYVTENYQQLWDDTLMMTVMPLAKIGKLLNRPEYIAEAKRQVLLHIQYLFDTKTGLWFHGWTWARGNSWVTMVIPEFVELLELKEGDPIRVHLLDTLEAQCEALQRVQEDDGFWHTLLDHPDSYVEASATAGFAYGILKAVRKRYLPVRYRGVAEKAIRAVLGAVDETGELQQTSFGTGMGDCLDFYKRIPLTAMPYGQAMAIMALGEWLRGVCRCVVKANVAIETSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBN3</accession>
    <name>A0A317XBN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_542123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472805.1">
        <property type="nucleotide sequence ID" value="XM_025613078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBN3"/>
    <dbReference type="GeneID" id="37115221"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="231"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY96044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="402" mass="44939" checksum="EFEDB01BB866258E" modified="2018-10-10" version="1">MNADSIQEIWTEVQSSLEAFQTTGTESTRIDALEKANKLARALEKPRDAILKLAYTPTALMAVKVAHDMQVFPVLAKATSPVPVSELAALKPADPLLVERMMRLCVAFGFAEEPTPCEYLPTAVTKEMVNRTSIGVVESLFLEFLPSVQKTPEYLQATNYRNPEDPLFAPLQYTNNMKEDGFSWLCENPDALARFNNFMEGQRADRPHWADWFPVQDRVLANADTTNPDRALIVDIGGGRGHDLLGFKKRFPDAPGKLVLEDLPLVIDEVQGAQDLDAANIVPVKYNFFTEQQPVKGARVYYFKNVMHDWSDDKARIILKHIVDAMEPGYSKLIMEEYIVPDRNASAIHGMTDVAVMVFCSGLERTTQQWTKLLDSVGLRVNKFWTRAGDGLGVVEAELATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBS2</accession>
    <name>A0A317XBS2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_531970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470761.1">
        <property type="nucleotide sequence ID" value="XM_025611019.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XBS2"/>
    <dbReference type="GeneID" id="37113162"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18022">
        <property type="entry name" value="DEXHc_ASCC3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000198">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000002">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000231">
        <property type="entry name" value="Activating signal cointegrator 1 complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000009">
        <property type="entry name" value="DEAD/DEAH box helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="290"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="519"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1151"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1356"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1910"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1942"/>
            <end position="1951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2000" mass="224463" checksum="7F1FD766709C926F" modified="2018-10-10" version="1">MAVNGSAESQWLAQLAAMRQAIADLKLPKDPARDQSYGSDLDLDFDEDYSSPGTADDDIWDIISSDDESSEGLDDFDDIPSPPISSSYDQIWLEQKCESLAASKPGIKAGELAQQINASLATDSGDDELQMSLAEIVGFDDLDFVIDLIAHRLDIVASLRTGPEAQTDGLMAGKLQTRAEREQALRQADYEHKHASLLPAQTRQEPHYPHVFKAYESRNVLAFGGKAYGLPMGSKQIDEKKYTEVEVPASKVGTLRPGHKLVEIASLDGLCQGTFKGYKTLNRMQSLLYEVAYKTSENMLICAPTGAGKTDAAMLTILNAIGKNTIPNPIEQPEATEFAVQVDDFKIIYVAPMKALAAEVTEKLGKRLAWLGIKVRELTGDMQLTKREIVETQVIVTTPEKWDVVTRKSTGDTELVQKVRLLIIDEVHMLHDERGAVIESLVARTQRQVESTQSLIRIVGLSATLPNYIDVADFLKVNKMAGLFFFDQSFRPVPLEQHFIGVKGKPGTKQSRENIDVVSFEKVRDMLERGHQVMVFVHSRKDTVLTARMLRQMATEDGCENLFSCQEHEGFSNGLSDVKRSRARELRELYASGLGTHHAGMSRSDRNLMERLFSEGLLKVLCCTATLAWGVNLPAAAVVIKGTQLYNPQEGKFVDLGILDVLQIFGRAGRPQFQDTGIGFICTTHDKLHHYISAVTSQQPIESRFSSRLVDNLNAEISLGTVTSVSEAVQWLGYSYLFVRMKREPRNYGIDFAEIRDDPMLVQRRRQLIVQAALVLQKSQMIIFNEKTEELRAKDVGRIASQYYVLQTSVEIFNNLMRPRASEADVLRMISMSGEFDNIQARESESKELNRLRDEVIQTEVEGGNDSPHAKTNILLQSYISRARIEDFALVSDTGYVAQNAARICRSLFMIALNRRWGYQCQVLLSLCKAIEKQMWPFDHPFHQFDLPQPILRNLDDKLPTSSVESMKDMETAEIGQLVHNARMGKTLSKLLDNFPTLGVEAEIAPLNRDVLRIRLSLYPEFSWNDRHHGASESYWIWVENSETSEIYHHEYFILSRKKLYDEHELNFTIPLSDPLPSQIYVRAISDRWLGAETVTPVSFQHLIRPDTESVYTDLLNLQPLPISALKNPILEELYGQRFQFFNPMQTQIFHLLYHTPANVLLGSPTGSGKTVAAELAMWWAFRERPGSKVVYIAPMKALVRERVQDWKKRLTGPMGLRLVELTGDNTPDTRTIRDADIIITTPEKWDGISRSWQTRDYVRKVSLVIIDEIHLLGGDRGPILEIIVSRMNYIASQSKGSVRLMGMSTACANASDLANWLGVKEGLYNFRHSVRPVPLEIYIDGFPEQRGFCPLMQSMNRPTFLAIKNHSPDKPVIVFVASRRQTRLTAKDLINYCGMEDNPRRFVRMSEEDLQLNLERVKDEALREALSFGIGLHHAGLVESDRQLAEELFANNKIQILVATSTLAWGVNLPAHLVVVKGTQFFDAKIEGYRDMDLTDVLQMLGRAGRPQFDTSGIARIFTQDAKKAFYKHFLHTGFPVESTLHKVLDNHLGAEVSAGTINTKQDALDYLTWTFFFRRLHKNPSYYGLEISAEEHNTMAAQAIAQEFMIELVDKSLGELAESSCIVLDSATGEVDPTPFGKIMSYYYLSHKTIRYLMAHAKPNPTFQDVLSWMCSATEFDELPVRHNEDLINVELARNLPLSVESMGDLPLWDPHVKAFLLLQAYMSRIDLPITDYVGDQTSVLDQGIRIIQASIDVMAELGYLNACHMFMSLLQCIKSARWPEESPLSILPGVNPGDKQSALPTSLTAFLSLPAKSVDSLQRKLNLPAQFTKATSYLPHLSLSLSTVSPTGITVSLTRKNAPKDKEIRIYAPRFPKPQTEGYFMLVYSATPDGKDAELLALKRVSWPSNRNGFGSGAGSSRRINDRSNNQKSGSLVVRSSVKFPQNQAGQSRRVTVKVISDSYPGMEWILSDVVINANADTGAVSETQTLPESSTFPEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCB7</accession>
    <name>A0A317XCB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UbiA prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_551880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472920.1">
        <property type="nucleotide sequence ID" value="XM_025613557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCB7"/>
    <dbReference type="STRING" id="1450535.A0A317XCB7"/>
    <dbReference type="GeneID" id="37115700"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY96159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35385" checksum="0A96905E866EC40F" modified="2018-10-10" version="1">MQQVSYERTWASAAKTIWLFTADDFTTFVVPETAFGICAALSGPLLTENGSPELLPVLKRIPTVILWNWLNLFVFNLANQRFPESVAEDKINRPWRPLPAGRISTTETRRLLLLAIPVVLGLSVYLGAWEETTLLYTLNWSYNDLGGGDDGFILRNVLLAIAFSQYNKGSLRVATQARFEILPQTWWWIIITSAVIGTTMHIQDIKDLEGDRAKNRHTVPIVLGDGPARWSVAVPVAIWSVACPAFWELGVGGYVLPVSVGVAIAWRTLFLRRTAADKATWKVWTAWTGVIWMLPLFKDYSVFVRFFQQLGWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD56</accession>
    <name>A0A317XD56_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Magnesium-dependent phosphatase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_531447</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471231.1">
        <property type="nucleotide sequence ID" value="XM_025610898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD56"/>
    <dbReference type="STRING" id="1450535.A0A317XD56"/>
    <dbReference type="GeneID" id="37113041"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="20540" checksum="44A62516DF20417A" modified="2018-10-10" version="1">MRTKRTNTQPLEDAFISPATFTDGLPLPKLIAFDLDYTLWPFWVDTHSKNIPLALASRTHTPDLARDMLKALHIIPTFSDNPAAKTKSVRALDYFDYVQIFPANKTQHFSRIQQASGVSYEEMLFFDDEARNRNVETELGVTFCLVKDGMTREEVDRGVRAWRKRNGIKSKKEGGEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD57</accession>
    <name>A0A317XD57_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cytosine deaminase</fullName>
            <ecNumber evidence="14">3.5.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cytosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_530376</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolytic deamination of cytosine to uracil or 5-methylcytosine to thymine. Is involved in the pyrimidine salvage pathway, which allows the cell to utilize cytosine for pyrimidine nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>cytosine + H2O + H(+) = uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from cytosine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.1" evidence="14"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472403.1">
        <property type="nucleotide sequence ID" value="XM_025610664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD57"/>
    <dbReference type="STRING" id="1450535.A0A317XD57"/>
    <dbReference type="GeneID" id="37112807"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004131">
        <property type="term" value="F:cytosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046087">
        <property type="term" value="P:cytidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019858">
        <property type="term" value="P:cytosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000016">
        <property type="entry name" value="Cytosine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF190">
        <property type="entry name" value="CYTOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="17">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00074321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00084039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY95642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="148" mass="16020" checksum="36B0C99DCA966A92" modified="2018-10-10" version="1">METDPGFIAAVEEAKLGAAEGGVPIGAALVSKDGKILGRGHNMRVQKGSPVLHAEMSALENSGRLPASAYEGATMYTTLSPCDMCTGACILYKVKRVVIGENKSFMGGEEYLKNRGKEVVVLDNEECKHLMENFMKEKPELWNEDIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDH1</accession>
    <name>A0A317XDH1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_454768</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472533.1">
        <property type="nucleotide sequence ID" value="XM_025607618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDH1"/>
    <dbReference type="STRING" id="1450535.A0A317XDH1"/>
    <dbReference type="GeneID" id="37109761"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0830">Ubiquinone</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY95772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="98" mass="10947" checksum="C4F67860A253C43A" modified="2018-10-10" version="1">MLCAGPSRCYNFWQEVLGCYVVNAGEGETGKKKCMPALEDYYECLHHKKEAIRTMKMQAAYRKAEAATPRENAPKAEQIRSLGLLGKEEEAAAFLSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDP9</accession>
    <name>A0A317XDP9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Kelch repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_505439</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473062.1">
        <property type="nucleotide sequence ID" value="XM_025609540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDP9"/>
    <dbReference type="STRING" id="1450535.A0A317XDP9"/>
    <dbReference type="GeneID" id="37111683"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="335" mass="36070" checksum="D3EA629F207571E8" modified="2018-10-10" version="1">MARAVWTKLLSDASIQRSSQTLAVVAGNAYLYGGELQPREPVDSTVYRIAVDCDGATDSRISPMIAPSTPQPRVGAASTAIKKRVYVFSGRGGTAMTPIEEAGSFWVLDPTTSGWSQVTPADPQSPYPVGRSYHAIANDGKDTIFLHAGCPEKGRLSDLWAFNIVTRQWRELAPAPKPERGGTSIAYAEGKIFRMNGFDGNKEQGGALDVFDPEKNVWNTIMYSADGISGPSARSVSCLLSLKVSGRPSLVTMFGEHDPSSLGHQGAGKMLADAWIFDIESQKWTKIEANSEEAPQGRGWFDADVIPGASQPSILVHGGLAESNDRLGDVWRLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDR3</accession>
    <name>A0A317XDR3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_619772</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473445.1">
        <property type="nucleotide sequence ID" value="XM_025616888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDR3"/>
    <dbReference type="STRING" id="1450535.A0A317XDR3"/>
    <dbReference type="GeneID" id="37119031"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000043">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1370.20:FF:000001">
        <property type="entry name" value="Catalase HPII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF3">
        <property type="entry name" value="CATALASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016277838" description="Catalase" evidence="15">
        <location>
            <begin position="16"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="53"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY96684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="728" mass="80357" checksum="0D2FBBE277E3F68A" modified="2018-10-10" version="1">MRLIGLVGLVGLANAFCPYMTGELSRRDSSDASESTEEFLSQYYLNDNNSYLTSDVGGPIEDQNSLSAGERGPTLLEDFIFRQKIQRFDHERVPERAVHARGAGAHGVFVSYSDFSNITAASFLAKEGKETPMFVRFSTVAGSRGSTDLARDVHGFAARFYTDEGNFDLVGNNIPVFFIQDAIQFPDLIHAVKPSGNNEIPQAATAHDSAWDFFSQQPSSMHTLFWAMAGHGIPRSFRHVDGFGVHTYRLVTDSGASKLVKFHWKSLQGKASMVWEEAQQVSGKNADFMRQDLWEAIEAERYPEWELGVQIMNEEDQLRYGFDLLDPTKIVPEEYVPITKLGKMTLNRNPRNYFAETEQVMFQPGHIVRGVDFTDDPLLQGRLFSYLDTQLNRHGGPNFEQLPINQPRVPVHNNNRDGAGQMYIPLNPNAYSPNTLNSASPKQANQTTGNGFFTTPGRTTAGHLLRSTSSTFQDVWSQPRLFYNSLVPAEQQFLIDAIRFETSNVKSTIVRQNVILQLNRISNDLARRVARAIDIPLPSPDPTYYHNNKTTDVGTFGTKLKKLSGLKIGFLASVQTPTSITAAKTLASDLTDDEVDVLVVAERLTDGVDQTYSASDAIQFDAVIIAPGAEGLFASGSLTAPQCPANSTIVSTLYPAGRPLQILVDAFRFGKTVGAVGTGKVALRNAGIESTREGVVVGQSVDGEFVDDVREGLKTFKFLDRFALDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE11</accession>
    <name>A0A317XE11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein UsgS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_529932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473326.1">
        <property type="nucleotide sequence ID" value="XM_025610560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE11"/>
    <dbReference type="GeneID" id="37112703"/>
    <dbReference type="OrthoDB" id="10041630at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN USGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28171" checksum="C1247C5160019A17" modified="2018-10-10" version="1">MESLKWVDSTYVDKHKAEDPNTLRAMYYPNLSLYSTADGKVKSTEPRKPAKERIFLFLRRSGQRAALLLGVSILSLVPVVGRFATPVASFYAFKGAVGTTPAAIVFGAGLIFPKSYVVSFLHSFYASRTLMREMLDPYFSRVPFTHEQRARWFADREGVLFGFAFAFTVVLKTPFIGVLLYGVAQAATAYLVTKVTDPPPSPAEKEGFAETQVTWKNKHEFLKLSLDNIDQLNKAQEEEKPSAPEVPGRKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE45</accession>
    <name>A0A317XE45_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_531757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471581.1">
        <property type="nucleotide sequence ID" value="XM_025610972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE45"/>
    <dbReference type="STRING" id="1450535.A0A317XE45"/>
    <dbReference type="GeneID" id="37113115"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="94" mass="10385" checksum="9251B04A1F50177E" modified="2018-10-10" version="1">MADSNESQPVAPVPRSTKPVSEALLNEKWDRAISSLIIRSSLGLSFGVVFSVLLFKRRAWPAWVGLGFGAGRAWEEADASFRRGDSPLRDALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF21</accession>
    <name>A0A317XF21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_482280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Also a component of the nuclear pore complex.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
            <location evidence="1 11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472369.1">
        <property type="nucleotide sequence ID" value="XM_025608885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF21"/>
    <dbReference type="STRING" id="1450535.A0A317XF21"/>
    <dbReference type="GeneID" id="37111028"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043935">
        <property type="term" value="P:sexual sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6 11" id="KW-0243">Dynein</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY95608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="94" mass="11031" checksum="97BAEFE34551646E" modified="2018-10-10" version="1">MASEKKDKLEPQIKSVDMTEDMQQEAVEVAIEAMDKYHIEKDIAQYIKREFDSRKGATWHCVVGRNFGSFVTHETKHFIYFYLGHCAILLFKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFQ2</accession>
    <name>A0A317XFQ2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic-L-amino-acid decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_619739</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6 7">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the group II decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473408.1">
        <property type="nucleotide sequence ID" value="XM_025616882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFQ2"/>
    <dbReference type="STRING" id="1450535.A0A317XFQ2"/>
    <dbReference type="GeneID" id="37119025"/>
    <dbReference type="OrthoDB" id="639767at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1340.10">
        <property type="entry name" value="dopa decarboxylase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010977">
        <property type="entry name" value="Aromatic_deC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021115">
        <property type="entry name" value="Pyridoxal-P_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999">
        <property type="entry name" value="GROUP II PYRIDOXAL-5-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11999:SF70">
        <property type="entry name" value="MIP05841P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00800">
        <property type="entry name" value="YHDCRBOXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00392">
        <property type="entry name" value="DDC_GAD_HDC_YDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="511" mass="57173" checksum="3EEB0423E2A83293" modified="2018-10-10" version="1">MDREQFRAAAYSAIDEIITYNDTLPSQRVLPTVEPGYLRPLIPSSPPEDPEPWSAIQSDIETKIKPGITHWQHPNFMAFFPAGVTYPSILGEMYSAAFTAPAFNWLCSPACTELETIVMDWLAQALALPECFLSTSSNRGGGVIQVTASDTVATMMIAARERRVTELVLAEGLKPDTVEYEDRMMDIRPRLVALASNQAHSSTAKAALLAGTRFRSVQARLEDNLEMTGERLREVLEQADRDGLTPYFITLGMGTTNSCALDRFTEIKAVLAEKEHWKRIWVHIDAAYAGAALVADEWQYIAKEFAEGVDSFNVNMHKWLLVNFDASCLFIRNREDLTNALDITPAYLRNHYSDSGKVTDYRNWSMSLGRRFRALKIWFVMRSYGLSGMKAYIRKTIGLGETFANLVRSRTDLFEIITKPAFALTVFRVKSPKSAIAEGGVAQPDEASNELTKEVYELVNSRGEIFITSTVVAGVYAIRVVSANPAAEEKYIRRAFEILVETAEEVIKRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317US78</accession>
    <name>A0A317US78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_480490</name>
        <name evidence="5" type="ORF">BO94DRAFT_480565</name>
        <name evidence="4" type="ORF">BO94DRAFT_480619</name>
        <name evidence="3" type="ORF">BO94DRAFT_480621</name>
        <name evidence="2" type="ORF">BO94DRAFT_596083</name>
        <name evidence="6" type="ORF">BO94DRAFT_616617</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000133">
        <property type="protein sequence ID" value="PWY63307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFK01000105">
        <property type="protein sequence ID" value="PWY63869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFK01000105">
        <property type="protein sequence ID" value="PWY63872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFK01000078">
        <property type="protein sequence ID" value="PWY64485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFK01000078">
        <property type="protein sequence ID" value="PWY64496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MSFK01000078">
        <property type="protein sequence ID" value="PWY64505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461300.1">
        <property type="nucleotide sequence ID" value="XM_025608800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317US78"/>
    <dbReference type="STRING" id="1450535.A0A317US78"/>
    <dbReference type="GeneID" id="37110943"/>
    <dbReference type="OrthoDB" id="4510867at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY63307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY63869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY63872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY64485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY64496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY64505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="126" mass="13394" checksum="585D02FB7A8A1E5D" modified="2018-10-10" version="1" fragment="single">AAYGPRVEGPDPADTLTNSGSRRAAPPGNLYKKAGQRPTIHRLHRCRGPRTAPGLQTPQQQRALPGMIKLAPTWLATRTHTVTISGVTGATIRNAWKLLTSSRRATGKKENLGPGKAPAAQEKTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UTG5</accession>
    <name>A0A317UTG5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_339362</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 15">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 15">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000058">
        <property type="protein sequence ID" value="PWY65363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461429.1">
        <property type="nucleotide sequence ID" value="XM_025607025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UTG5"/>
    <dbReference type="STRING" id="1450535.A0A317UTG5"/>
    <dbReference type="GeneID" id="37109168"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000006">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000011">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="17">
        <location>
            <begin position="51"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="18">
        <location>
            <begin position="250"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="420"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY65363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="453" mass="50454" checksum="0BAFB9079E494D55" modified="2018-10-10" version="1">MRGEICHIHIGQAGIQLGNSAWELYLLEHGLKADGQLNPDASDVINSGGSFETFFSETGNGKHVPRSIFVDLDPSPVDEIRTGKYRQLFHPEMLISGKEDAANNYARGHYTIGKELVEEVADRIRRVADNCSSLQGFLVFHSFGGGTGSGFGALLLERLSAEYGKKSKLEFAVYPSPRVSTAVVEPYNAVLSTHSTIENADCTFLVDNEAVYDICRRNLDIPRPGYEHLNRLIAQVVSSITSSLRFDGSLNVDLTEFQTNLVPFPRIHYPLISYAPVVSSSRSSHESFKVQDLTFQCFEPNNQMVVCDPRKGKYMAVALLYRGDVVPRDCTQAIASLKAKSSFNLVEWCPTGFKLGINYQKPVRVPDTELAPVDRSVSMLSNTTSIAEAWGRLDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVANDNAEAEGEEDEAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UUU1</accession>
    <name>A0A317UUU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_387053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000081">
        <property type="protein sequence ID" value="PWY64282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461270.1">
        <property type="nucleotide sequence ID" value="XM_025607296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UUU1"/>
    <dbReference type="STRING" id="1450535.A0A317UUU1"/>
    <dbReference type="GeneID" id="37109439"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY64282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="121" mass="13865" checksum="33B086883F805FA1" modified="2018-10-10" version="1" fragment="single">AAPSSKLTLFLSSPAGKKWFDCAECHQEQESHSLTKTNEMVFACKKCKKCFRKDATEFDESDEYCPHCDNHFVIEAVTPTPTLQVEGEDARVDSRMLKDDRVRGHQERSIFNFKDLSDRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UX96</accession>
    <name>A0A317UX96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_540651</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461629.1">
        <property type="nucleotide sequence ID" value="XM_025612961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UX96"/>
    <dbReference type="GeneID" id="37115104"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="74"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY66365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="586" mass="63239" checksum="63F61BFD5FF45BA0" modified="2018-10-10" version="1">MVTSVTSTVVTDSCEPMNTILAINHTSAAEPEHNVPSASRESPKGAAVGERTDGHEEIEIPAATPKTSIRFFAIIAALALSGLLTSLEATITSTALPTITADLGGADLYVWVVNGYYLTQTAFQPLFGQIADIYGRRWPMIISAVMFTLGSGLSGGASNINMLIAGRLIQGIGAGGINVLIEIIVCDLLPLRERGRYLGLMFGLIAIGTTLGPLFGGLIVQYSTWRWVFYLNVPIGGAAMVILYLFLRVKSDHTPDYWMRLKRIDWIGNTVFVLAMVSVLIALSWGGSQYPWSSFRIIVPLVMGFVGFGLFLLYEASPYCINPTMPLHLFANRTSGTAFGLTFLHSLSAISVMYFLPVYFQAVLAASPSRSGVDLLPTILFMIPAAITAGGLLSKLGRYRPIQHVGFALMIIGFGLLTLLHADATTGQWVGYQVLSALGTGLALPLLLPAVQASLTESDTALSTSTWSFTRSFGLIWGATIPTAAFNNRVNTLLGRVTDSAIAAQLADGKAYEQATKRFMDSITDPVIRAQVVSVYVDAIRTVWYVSMAFAGLAFLLVFVENEIPLRKELETKFSIEEKDGEKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYV0</accession>
    <name>A0A317UYV0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dockerin type 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_561269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000050">
        <property type="protein sequence ID" value="PWY66796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461732.1">
        <property type="nucleotide sequence ID" value="XM_025614207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYV0"/>
    <dbReference type="GeneID" id="37116350"/>
    <dbReference type="OrthoDB" id="9978204at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15892">
        <property type="entry name" value="BNR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49588" checksum="99367908AFC35E71" modified="2018-10-10" version="1">MALLFTTDLGDDPNTTHRLNACAYQQSAITTFDSIQYVAFYTSYEASEGRRVTIARHDIKDTSSDWQYLTFEDYEQTTDDGHNTISIGICAGDGTVHVSFDHHCDMLKYRISRPGLANDPSRSSWTATSFSSILDHLPGCDSLVDVTYPRFIPAGKQIYFECRIGKAGAGSDILYCYYPDTAQFAYLGAYLVGRQCNPYPNGLSYHPPTSSLHVTWTNRHFIDYEGANDGASTAHKAQAGPNGPENNEGLYHAYSRDNGVSWYGSDHQPVAILSSRPGTGLDSQDGRLRAKDIPRNSGIMNQEAQHVDANGGVHVLNRENVNGNETWMHYYRSSLSDQWASFALPGLYPTPTGPRGKVIHSEKLDTVFFILPSNTEHELIITRRSMGDTSQKLHVVWRDIGYTGEPLVDKEAFAQFGILSIFILKDIEEGRRKVVVLQFDLSELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZP8</accession>
    <name>A0A317UZP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_504507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461547.1">
        <property type="nucleotide sequence ID" value="XM_025609510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZP8"/>
    <dbReference type="STRING" id="1450535.A0A317UZP8"/>
    <dbReference type="GeneID" id="37111653"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF68">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="83"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY66037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="520" mass="57094" checksum="C4ACCF3267E82509" modified="2018-10-10" version="1" fragment="single">MPTEPPEDVDYSAALSQETSLESADTVYVEKEVVHIEEGEITLQDSALESGDSLDKDDSLVHWNGPNDPQNPMNWSSVQKWLTIGLISISSFNVSMVSTVFAPGVPEVLQEFNIHNSSISSLMISIYVMGSAIGPLVLTPLTEISGRLPMTHIANFLFAIAAVVCATSVNTGMLIASRFVMGIASSVPVTVGGGFVADMMPMKKRGTAMTIWTVGPLMGMVTGPIFGGFIVQNVGWRWTIWLEAILGGVIAIASLIFLRETYAPTLLQRKAKKLQKETGRYYRTKYDTDKTLGQIIWVSLSRPIKFLCLSPIVLIVSLYSSVTYSYMYILFTTFTGIFENVYGFTPGEAGLGYLGLGLGFCFGQITVGYYSDRYLKKQEKLHGTMKPEDRLPPLVLGCALVPIGLFWYGWAAEYRVHWIVPITGTFFVGAGIYYVHLVTQVYLIDSYTLYAASAVSAELALRCIFGATIPLAADPLYDALGLGWGNSLLGFIALAFAPSAFFLLKYGERIRTNPKFQPRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V133</accession>
    <name>A0A317V133_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arad-like aldolase/epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_612306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461823.1">
        <property type="nucleotide sequence ID" value="XM_025616664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V133"/>
    <dbReference type="STRING" id="1450535.A0A317V133"/>
    <dbReference type="GeneID" id="37118807"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF39">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="55"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY67101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="291" mass="32243" checksum="C377359FDBBB0E32" modified="2018-10-10" version="1">MTTTTETTTQTNPNNGTPSQFFDEVHFLGDKEGKVVIRSPPTFTTAEESREYQKQHLAAAFRVFAKQGFDEGVAGHISLRDPLNPHHFWINPLSTHFSLIRVSDLVLVNEHGQVLPGGAQSPINGPAFAIHSEIHKARPDLNAACHAHSVYGKAFSCFARPIEMLYQDALRFYNDLAVYPRYGGTVLSTEEGARIAKALGPTCRSVILQNHGMITCGKTVDEAAFLFIALDRCCHAQMMANAAAGPGWEKVFINREEAELTHRKSGNSSKMWLAFQPYFDQVVREDPAVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V533</accession>
    <name>A0A317V533_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_628773</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY67977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462026.1">
        <property type="nucleotide sequence ID" value="XM_025617508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V533"/>
    <dbReference type="STRING" id="1450535.A0A317V533"/>
    <dbReference type="GeneID" id="37119651"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY67977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="559" mass="62503" checksum="9CF2E457AFCF3283" modified="2018-10-10" version="1">MPCSPHPFNDPIPDACPNLLSIPAQVREVYPGRLFTPEALARLTTTNRRFIARILRYLRPKSWIDAIPNDPTLPSRIGILPSGKWNRPCNLSHEAAPAVAYAIETGHLDRVMELVERTRIPANSSDRNSNCLLHIALVSNQIEIAEYLLLRGAYADGYHPSTIPELDHLFLSPSNTGPQCPIVRERILTLLLSHRASISRFPTQNMFYINPRNAPRFLEYLLDNHPEIADLRSASGHTLLHTAAALGDPESCEFLLERAPHLLTIDTDWGVTALHLAILEKNEPTACFLIDRGIRLHFRDKYNRTELFLAAAMGLPTVVEHLLELRTAERSYISGKWRYDAKAAVRLALYLGYEEIVRLIRNKYNLTWLAILKGYLTWANIPQTPKAPRAQAPRHRRRGTPRNLSSGQFVHRHRRRTASVTPTPTPHAHAHARSHNQGRGARGRAFQGRHHGRRRSTSVRSNTPTSVVGGSASGSASEARERITWWCGINTVNPMLKLRDIGTLGTCDISSVRRVLCGVERDISSLGGSGISRCFAVSELLVCVVSARLSGCWVCHQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6V9</accession>
    <name>A0A317V6V9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD-dependent protein deacetylase</fullName>
            <ecNumber evidence="6">2.3.1.286</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_527375</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462404.1">
        <property type="nucleotide sequence ID" value="XM_025610383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6V9"/>
    <dbReference type="STRING" id="1450535.A0A317V6V9"/>
    <dbReference type="GeneID" id="37112526"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017328">
        <property type="entry name" value="Sirtuin_class_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037938">
        <property type="entry name" value="SIR2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="13">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="332"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 10">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="44"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="218"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="242"/>
            <end position="244"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037938-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY69199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="378" mass="42200" checksum="C34E7AC3A7EF4E40" modified="2018-10-10" version="1">MGNEPSTMVDEHTPPTVLEARTIEAVAKYIEQRSVQRVVVMVGAGISTSAGIPDFRSPDTGIYSNLECLDLPEPEAVFDIDFFRENPRPFYALARELAPGKYRPTIAHSFIKLLYDKGLLMKHFSQNIDCLERLAGVPGDMIVEAHGSFATQHCIDCKVEYPDDLMKEAIAKGEVPYCAQCKGLVKPDIVFFGEALPANFFDNRELPEQADLCIIMGTSLTVQPFASLPVFCREGVPRVLINMERVGGLGSRPDDVLVLGDCDTGVRKLARALGWEEELEELWETTKPDKGAQEAENAPLQTREERLQDEVDRLTEEVDRTLGISNAYQQRVRQHLERQSSKNTDAADDTKRDEETDRIGGLAHVFPHLARVKEGKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6X8</accession>
    <name>A0A317V6X8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_560694</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462554.1">
        <property type="nucleotide sequence ID" value="XM_025614175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6X8"/>
    <dbReference type="STRING" id="1450535.A0A317V6X8"/>
    <dbReference type="GeneID" id="37116318"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY69856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="313" mass="33797" checksum="5C1753338855C381" modified="2018-10-10" version="1">MSPISVSHPGDQGNQKESYTQLPDTDLDSIGRHCQLSYCNQLDFLPFHCSSCKGTFCLDHRSETAHKCPRAGEWARAQNPSPSPSSASSASSQKPTVYNSDQCAEISCKTLIRTLKDPGVTCPECRQSFCLKHRLREEHDCRPKKGGNNSGGAVGAAGAETLKSMFAKMRTWGKNAASTSTGGAGGRAGDRGMSRVAQVNAMKRSAKGDANVPVDKRVYLAVVGTSETTTRAATDPPRGEFWYDGRWKVGRVLDDAARRLQVENMNNRGGGEEERLRVFHVEGGVFLEFSDAIGEKVKSGDTVVLLRGAGVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V856</accession>
    <name>A0A317V856_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_477374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462607.1">
        <property type="nucleotide sequence ID" value="XM_025608639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V856"/>
    <dbReference type="STRING" id="1450535.A0A317V856"/>
    <dbReference type="GeneID" id="37110782"/>
    <dbReference type="OrthoDB" id="427960at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10175">
        <property type="entry name" value="MPP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="192" mass="20719" checksum="61151D24C2683C68" modified="2018-10-10" version="1">MRGSPSSGAKPDKSMSSRLLTMKFMQRAAATNAAREASQPSTDDSKVSTPPKRQRLSTGPTDSPTPQSDLDAISAALAEEEEKRKEALARQAQDSGDTEWVLDYAPAAYAPPPFVVADGSLDADDDDAGGRQAYGNFKRKKRTVTGEEAEDEDDASVKKEKPRVKVSQLTSISGGRHGTVGDDKKQKKRKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V858</accession>
    <name>A0A317V858_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_477823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462382.1">
        <property type="nucleotide sequence ID" value="XM_025608665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V858"/>
    <dbReference type="STRING" id="1450535.A0A317V858"/>
    <dbReference type="GeneID" id="37110808"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY69177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="16069" checksum="12A95F8E476220B3" modified="2018-10-10" version="1" fragment="single">FIVCGALVAAVGYNVLATQTTVAARYFGLFLATQVFVSIALILTWVGNTHATDSKRAGAFAILATGGQCGPILGTNIFPYSDKPYYRKGMWISCCACLAVVVMGCCQMFLLWRANQRLDGESQRNGGDLNVNQSEIRDGTDKKVRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8C5</accession>
    <name>A0A317V8C5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_539761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462596.1">
        <property type="nucleotide sequence ID" value="XM_025612770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8C5"/>
    <dbReference type="GeneID" id="37114913"/>
    <dbReference type="OrthoDB" id="4509548at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016347681" evidence="2">
        <location>
            <begin position="21"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY70305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="310" mass="34106" checksum="9F1378C3213E3ECA" modified="2018-10-10" version="1">MKIFNLLLLWCSVLFTNVLADNESIANELIYFYYVYKMEFLSGATKTMAVDCEGSAHGGMCYFDEFVEHLIEDRWLNVYDPLPGDHTITPGDAQIPRLERNLPSSARYKLSSLLSTLNGETAFPIVLQKVLHAANEAFEAAEDNDVTLATSDINAAVDNARAAKEARNRAIFDLQQDALSRRLDAAIVDYVQSTASGFKWPQTFQAIDDAVDDGELDKATAKDYKSQLRTFSKSYEHDIISSVTSEMTHLDVVRSFATSITRYTRVMEDREPGSTGLDASSSSSECSDEFSSDSTSSDESSSSSGGSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8X1</accession>
    <name>A0A317V8X1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium permease family membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_610631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462517.1">
        <property type="nucleotide sequence ID" value="XM_025616612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8X1"/>
    <dbReference type="STRING" id="1450535.A0A317V8X1"/>
    <dbReference type="GeneID" id="37118755"/>
    <dbReference type="OrthoDB" id="16982at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000017">
        <property type="entry name" value="Calcium permease family membrane transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF10">
        <property type="entry name" value="VNX1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="635"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="952"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="989"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1025"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1052"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="domain" description="Inner membrane component" evidence="11">
        <location>
            <begin position="266"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="538"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="920"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="798"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="798"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY69819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1111" mass="122869" checksum="EC48729102A1BD4F" modified="2018-10-10" version="1">MSNNDQMEDQGLSYPIEPEAPSNLDSEDMSSGTLRQSRNATQSRRNYGTLESPARMDLDLQPDESQPESSSRIHTCQSTSSTPLPSDRPRKPSVTRRMSSKRQVPHKGQEFSTEDDVQEVEEDIALQQATNPQSSPRIRPLRKQSSTLRRRLNARISSPLTQPDSDNEGEEGPSLPDPVTEIEPSAEQSESGSHDGDDNNGEDEAESSDAESFTLKDRQQAINETHPFGIRLWKPALYKKSRSVEKTAEGDIHSSPGGRVGNLLFLTNLLWTVFFGWWLALAALTGAVACFVFAYSPSAVEYGRVFSGLSWYLIYPFGSFVRLDTDENYAEEDEGEGRSISEYEQWQNGDLEHGRLFFGPRRNRSLVGRRRSSVDSASEQDSLLGRTQRGSPRENPLSHPKRRLFGRGEWTLGRVVFFVFFYFLVGPLMLLVSLLCWLLVFWIPMGRVTIILFDHLRRHPLALSYHSDTTYTRLSPGSSSSILLCTYRAAGLRYWKYTVGGTNIFLINLLGVVLFVILDYFLLRETLGLQTTITHPGFIFTLALVSIIPLAYFIGQAVASISAQSSMGMGAAVNAFFSTVVEVYLYCVALTEGKGQLVEGSLIGSIFAGILFLPGLSMCFGAIKRKTQRFNVKSAGVTSTMLMFAVIAAFGPTLFYQIYGSHELNCRLCVTTVGTEDSDCRRCYFSQAPAVNDSFFRKAVQPYSWFAALFLFLSYVIGLWFTLRTHAALIWATEIEEKKAIALANEQASYEARHGDLPHLSGGSITKGSVRDSQLYKRILGQSLKQVGLSDNHIDYTTGQSDSASSLRGKSTTPYLVPPRTEGDDGNSRLKNFGGLSHEDNENLVRQVTEVAATAAAVAARDAARTKKPFVQQVTPRQANKGPADQVKVLLEENEDIGLEPGNASGGHDAPNWSKARSSIILLGATILYAIIAEILVNTVDVVLESVDIDEKFLGITLFALVPNTTEFLNAISFAMNGNIALSMEIGSAYALQVCLLQIPALVLFSAIYARVIDPSELLSHTFNLIFPQWDMVSVILCVFLLSYVHGEGKSNYFKGSILVLTYLVVVIGFYLSGYSNLETMGIDRFDTLALASSPAEKFYTIGRSRNGRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V927</accession>
    <name>A0A317V927_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_609189</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462767.1">
        <property type="nucleotide sequence ID" value="XM_025616576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V927"/>
    <dbReference type="STRING" id="1450535.A0A317V927"/>
    <dbReference type="GeneID" id="37118719"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY70873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="353" mass="39952" checksum="15D8F04BD245CF8A" modified="2018-10-10" version="1">MLIFFFRYVLGPPGQSVRSAIAKVGYGVTSTVWFARDLVNSTYVVLKLYVLGQERDHELKIYNHIQFIRKLLNHFFIDGPHGRHICLVHEPLGMNTSDLLHSIPGKTMTLELMKPAIRQLLRALDFMHSVAGVIHTDIQLKNLLLPAPSASALSDFEERTINQPVPRKVLKDRTIYTTSSFPAGDGYPLLGDFGEARIGNEPRNESIMPDYYRAPEVILKSTWDYKVDIWSVGMVAWDIVSPRTLIKGNTIDGISDDGAHIVELVSLLGPPPSSFLKNTPMSRIFWDESGAWNNLVPIPDQNLDNLAADIRGEDVEGFLRWLRLALQWNPEDRLTALELLMDPWLMKGLNLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VA07</accession>
    <name>A0A317VA07_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thymidylate synthase</fullName>
            <ecNumber evidence="4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_292805</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462555.1">
        <property type="nucleotide sequence ID" value="XM_025606696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VA07"/>
    <dbReference type="STRING" id="1450535.A0A317VA07"/>
    <dbReference type="GeneID" id="37108839"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000005">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="12">
        <location>
            <begin position="36"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY69857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="354" mass="39249" checksum="7C34878A6093AA92" modified="2018-10-10" version="1">MSPSAESLPTPPQDATTTTTTTPTPTIPHDPTHEEHQYLNLIRRILSEGEYRPDRTGTGTRSIFGPPQMRFALSKPNPTSTTPSDAYTPILPLLTTKRVFLRAVLAELLWFISGSTSSLPLSSAGIKIWDGNASRTYLDSIGLTHREEGDLGPVYGFQWRHFGAEYVDSSTDYTGQGVDQLADVVKKLLTNPFDRRIIMSAWNPADLGKMALPPCHMFAQFYVSYPDADEDWKAGNKGGDKGRGHLSCLLYQRSADMGLGVPFNIASYALLTHLLAHAVDMVPGTLVHTLGDAHVYLDHVEALREQVEREPVAFPELRIKREDRGSGIVDGWKDEEFEVVGYKPHKAIKMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VAH6</accession>
    <name>A0A317VAH6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_560613</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462650.1">
        <property type="nucleotide sequence ID" value="XM_025614166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VAH6"/>
    <dbReference type="GeneID" id="37116309"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="114"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY70359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="551" mass="62677" checksum="DD108DBF2F622B00" modified="2018-10-10" version="1">MTMLTIGRFLSRSYPHTRDGPTIFSFQQRLIMEEGGAYDARKPESVASSSSPALHPTADYDLSETEEALGSPDTFYSPPASPGRLSRNPSFSYHDDWETFPPLDQLTVFDLLDNLSLSQRLEKLQRALNAQKDKVKRQREKLKSTSINAKERVVGEWKRRVPTADEQLDKYRRRMKDGVERLGKQWNATATVTLREKISFIAGVLNILVSGYLLGGSPEYFYIWFSAQLAYFMPIRFYRYHKRGYHYFLADLCYFVNMLCMLSLWVFPGSKRLFISTFCLVFGNNAVAIAMWRNSMVFHSMDKVVSLFIHIMPPVTLHCLVHMTPTDILKERFPAIYEIKSSEPGSPNHFNLLEMMGWATVPYMIWQLTYHCFITIRRAEKIAAGRPTSFTWLRKSYAKTWIGKVVLGLPESLQAPAFMLIQYAYAILTMIPCPLWFWSRWASGIFLTGLFILSVHNGATYYIDVFGKRFQKELEELKKDVARWQSSPEGVISPTLLTSDNAATSGATAVEESASGGSEKASIDQIPLLDAHSTGVEGSHVADNSVVRERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCT7</accession>
    <name>A0A317VCT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_526331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462816.1">
        <property type="nucleotide sequence ID" value="XM_025610349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCT7"/>
    <dbReference type="STRING" id="1450535.A0A317VCT7"/>
    <dbReference type="GeneID" id="37112492"/>
    <dbReference type="OrthoDB" id="1938992at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="321"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY71061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="612" mass="68110" checksum="E3F22C0F6376472F" modified="2018-10-10" version="1">MTSTTLMPVRVSLRRDPSGHSPDQLDPEPPAKRPRLQHLSSRRRKSSPDLLDTTTTENSSSAASPYKLSPHPLRRRTSTRRPLANNPTASPVTPRPTDRRILRNESHPTIAPASLYLRGGRESPDPLDTISPAATIKSSVSRRLSPAGRPSAAAAAAPSSSARRPRRSAPAPNPDPEPAVTPVQHEAGALSSNPAQSSQDATAQQTSPTTEQPSTSREQRRSLRSHDGGSRARSELAQYFPNYEELISFETPKPEFLAGSTTIKIIDDLSEPLIPFSSDTDTDTPFGNPLLNLHNCETIKLSDPLPPSHSNTAESSSTSPDPLSEETYFRPHRRNERQEKQLRNIERDHNQYEKQKLDRLLDDLQGHDWLRTMGITGHINDQERKHYETKRAHFIQEISAVLQKFKIWKEEEKRRKLEKDNKLIEEENNKDHTPETTTNDEEDDGDSNNNNNGTTAVSDVQSYGGDPPDPNDVDAWAARQLHQEARSATTTSSNATPTTGKKSKPSSTSKKSSNSNTMPPPPAPIPHLLPLPLEPDKPFTSFFSKPHLRELALSATNRKGRTRLAFGHPIPEMDEREFELPAEILTPEAIDSCRRKRRRMKRASGRGETETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGS5</accession>
    <name>A0A317VGS5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_475995</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463161.1">
        <property type="nucleotide sequence ID" value="XM_025608588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGS5"/>
    <dbReference type="STRING" id="1450535.A0A317VGS5"/>
    <dbReference type="GeneID" id="37110731"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15965">
        <property type="entry name" value="zf-TRAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="39"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY72208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="427" mass="47570" checksum="D154622C40A15139" modified="2018-10-10" version="1">MTSITLDELRAMEANCDRDEVVDLRSLETVSSYDDHLMCPICHCPFVRPVRLQCDHVFCQKCLNSAITAFAASRDDFTCPTCRTPTRGVYLNVPRLLLNMCDDIRVRCPCRDEGCQEIIPRGHVQLHVDKYCGYRLMKCPDGSCSKKTRKKNLGPEGRCLHEPHRCLRCHEYIMEQDYETSVLRKALREHIDACPQVVHACTASKYGCPVKVKRADLATHEQTCPLIAMGPYFEAQNARLDSLELTIRHLQQRNEIFEDGIANIRSTLVQSSRALAEPESSPANSDPPRRESSSNQSQIDSSNLYTAATTNYLLSLHESLREEVGQLSHAITDLDARASMALMNECLRLKEDMAHTNAAVGSIRMQVQWLLNPRLQQSQRAGARPGNANTGNGNPASASGPSSAAGPSTAFLRPRRLSDSGREGTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJR3</accession>
    <name>A0A317VJR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF255 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463357.1">
        <property type="nucleotide sequence ID" value="XM_025612599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJR3"/>
    <dbReference type="STRING" id="1450535.A0A317VJR3"/>
    <dbReference type="GeneID" id="37114742"/>
    <dbReference type="OrthoDB" id="1923667at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="Ssp411-like_TRX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899:SF1">
        <property type="entry name" value="SPERMATOGENESIS-ASSOCIATED PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spermatogenesis-associated protein 20-like TRX" evidence="1">
        <location>
            <begin position="21"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="783" mass="87171" checksum="C932EB04DFA817CE" modified="2018-10-10" version="1">MAAPLDMHHDGATVTGPRLVNRLRDSKSPYVRAHMNNPVAWQLWDAEAIDLARRHNRLIFLSIGYSACHWCHVMEKESFMSQEVASVLNESFIPIKVDREERPDVDDVYMNYVQATTGSGGWPLNVFLTPDLEPVFGGTYWPGPNSSTLTGTETIGFVEILEKLGDVWETQQLRCRESAKEITKQLREFAEEGTHSYQGDRQADEDLDIELLEEAYQHFVSRYDPIHGGFSTTPKFPTPSNLSFLLRLGIYPSAVSDIVGRDECEKATAMAINTLINMARGGIRDHIGHGFARYSVTADWGLPHFEKMLYDQAQLLDVYVDAFKITHNPELLGAVYDLATYLTTAPIQSPTGAFHSSEDADSLPAPNDTEKREGAFYVWTLKELTQVLGQRDAGVCARHWGVLPDGNIAPENDPHDEFMNQNVLSVKVTPSKLAKEFGLGEDEVVRIIRTAKQKLRDYRERTRVRPDLDDKIIVAWNGLAIGALAKCSTLFEDIERSKAVQCRGAAAKAISFIKEHLFEKTSGQLWRIYRDGSKGNTPGFADDYAYLIGGLLDMYEATFDDSYLQFAEQLQKYLNRQFLAYVGSTPAGYYTTPSTMTAGTPGPLLRLKTGTESATPSVNGVIARNLLRLASILEEEAYRGLARLTCHSFSVEILQHPFLFVGLLDAIVGLETGTRNVTGVFSTAVIEGSVQASEGVIRKTDEPVCVRDLIVQKIRAEAGLAISTATTTASLVDIRPSHVGDFVGNQSFWLRTRNAMYRELEPSETAKNHLMVCESGRCRMVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJW4</accession>
    <name>A0A317VJW4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear distribution protein nudF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lissencephaly-1 homolog</fullName>
            <shortName evidence="11">LIS-1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nudF</name>
        <name evidence="11" type="synonym">lis1</name>
        <name evidence="14" type="ORF">BO94DRAFT_232217</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Self-associates. Interacts with nudE and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
            <location evidence="11">Cytoskeleton</location>
            <location evidence="11">Spindle pole</location>
        </subcellularLocation>
        <text evidence="11">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJW4"/>
    <dbReference type="STRING" id="1450535.A0A317VJW4"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <keyword evidence="3 12" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="13">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="193"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="340"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY73749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="440" mass="48405" checksum="14B952EFE0337AA9" modified="2018-10-10" version="1">MLLARLSAIRHKSIIAYLSSINASRSCEALREELQVDNSFDDALCRKYEGLLEKKWTGIARLQKKILDLESKLAGLQTELDTISPTARSTGKDPTNWLPASPRHTFESHRDAVTCVAFHPIFTSLASGSEDCTIKIWDWELGELERTLKGHMRPVSDLDFGGQKGHTILASCSSDLQIKLWDPNKDYANVRTLSGHDHSVSAVRFLRQTDNILVSASRDASIRIWDVSTGYCVKVIDSHGSWIKDVSPSFDGKWLVAGGRDQAAVVWEVASAKSVASLIGHENYIECCVFAPPASYKHLAAIAGLKQPPPSSSSSEFIATGARDKTIKLWESRGRLIKTLVGHDNWVRSLIFHPGGKYLISVADDKTIRCWDLSQGGRLVKTVNAHGHFVSCIRWGPVTVSDVSVENTESTKSSKTDVVKPGFRCVIATGSADSSVRIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VL54</accession>
    <name>A0A317VL54_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_475185</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463619.1">
        <property type="nucleotide sequence ID" value="XM_025608551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VL54"/>
    <dbReference type="STRING" id="1450535.A0A317VL54"/>
    <dbReference type="GeneID" id="37110694"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY73867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="167" mass="18909" checksum="DD98CC411DF39E20" modified="2018-10-10" version="1">MAEHLQASVGSLQSSLQILDSSISTLDAGISDFPRLCKVLQTTRHFELLPEPTLREAQQSLLDEITPSIAHLLSLASNHVEKLSRREQGLRAKCELQEGRMYSNESRQPSRLRSAYGDRQGASGNAAKAAELRRLVQKKERLQYAVERLELQSTQRERQLRKSMAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLL6</accession>
    <name>A0A317VLL6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_538803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463514.1">
        <property type="nucleotide sequence ID" value="XM_025612563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLL6"/>
    <dbReference type="GeneID" id="37114706"/>
    <dbReference type="OrthoDB" id="5372935at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="271"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY73762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="320" mass="36831" checksum="B5A887B5DCCD4803" modified="2018-10-10" version="1">MSKMNSLSKALEKVNLNDAAKSTSKAKPQRKKQARKGPVEPFRFFDLPSEIRLRIYGFVLFTPRRRRTPRTTGNVGASSKRNPPLSPTSHRVALFLTSRRMHNEASDYFYATQTFRLFHIQDYSRMPTIRAIAPQYRPSIATIELILGSSWTAPPREWTVTRSLGLEEMVRIRTFKVFIECDPSHPVFEGFRVSKDYYTDFAGDLLSEVLSKLPNLEYVEFDAWPSVRKSGALMKRLMEEVRTAGRKIAWGPERGWTDYDGEEFSDDVYGIKAHEKAQERAQQEKAQLIKAQEEARELARLNGFSPQTLPVPLLSPYLYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQ87</accession>
    <name>A0A317VQ87_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_549416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464102.1">
        <property type="nucleotide sequence ID" value="XM_025613445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQ87"/>
    <dbReference type="GeneID" id="37115588"/>
    <dbReference type="OrthoDB" id="4499271at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY76105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="349" mass="40847" checksum="763BF5D00B202AB8" modified="2018-10-10" version="1">MSEVSNPISKLESYISRLLDEAGIPNCIWGERVLNILGTSVFDCPIYFGGSKCSVDQPFTGHRRFLLWVIPDRYIDQAAQILDKAKLSRDGDNRAGWSMGDYVYLPPSQLNVKQTIHLFRKSRISWTFPDPPVGRLGWEDSYFYCLTSDQKFRHETIQLSDRPSEKDWPVKMPGPEPFFEALVSLCVREYEAPLTQSFWQKAAHRLVRDVLHRQNRPYMRIDNILSPFHFYDAELSRAITQNAKDRWLYDIYRAMKRLNELPRPERGLLSGYRRSECMQETRPRMDTGLDHLQNDCSELQDSRDWCKRRAEDIKHDIARGITELRKQLWNLRPLPHIRLGAITGDGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VR22</accession>
    <name>A0A317VR22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_212738</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463969.1">
        <property type="nucleotide sequence ID" value="XM_025606167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VR22"/>
    <dbReference type="STRING" id="1450535.A0A317VR22"/>
    <dbReference type="GeneID" id="37108310"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY75342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="190" mass="21997" checksum="9E626D5B1D2033C5" modified="2018-10-10" version="1">MGKSQSKLSPSQLEELQKATHFDKKELQQWYKGFLKDCPSGTLTKEEFQKIYRQFFPFGDPSSFANYVFRVFDSDNSGMIDFKEFICALSVTSRGKMEDKLDWAFQLYDIDGDGKITYDEMLAIVEAIYKMVGSMVKLPEDEDTPEKRVRKIFRMMDKDENGSLDMEEFKEGSKRDETIVSALSLYDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VT24</accession>
    <name>A0A317VT24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_523714</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY75988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463985.1">
        <property type="nucleotide sequence ID" value="XM_025610230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VT24"/>
    <dbReference type="STRING" id="1450535.A0A317VT24"/>
    <dbReference type="GeneID" id="37112373"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="11"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="98"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY75988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="601" mass="68549" checksum="1982CE9C8CE57DAB" modified="2018-10-10" version="1">MGSAHTAPIQLPGFNLPLNHKPKGKHNWDMTLYPNALDYANIHDGYVGHINTQRELTMVQIMNAISEKPDWERKVLDDAITSKWEKEIMESGRNVSPRMMEWIIKEMHWKADTLKRQGLVTVFDIGVVRSDTAVSSEVQQALRHAVAPLEDIPNEQKDYHPGSDGKVLDLVHPSLFPLVYGRTRILPDRVITVDDCMGSIGEGVILAVPPEEEAGLGAGHSGRWMPWQMRGMHPYSQKFQWLPCNVQLPEEGGCRITSYINNLSPTKHQPLYQVVEKIIDASIPLWDTSLTEVRGFQNERIPYEKVVYLDHPEPEPEPKDEEERWSDEFCERHDEWRRSTPIQLPEPSTRFSPPRPNWRGQVNLRETFREQGLQVIVKLANIELTPKSPEYAGGSWHIEGQLNERICATAIYYYDSHNITDSQLCFRQRASTDMSDINYDQDQHEFLQAVYGFGPDVPGSGDTQITQDLGSVRCNEGRLLTFPNVVQHCVAPFGLADPSQPGHRKILALFLIDPNRRIISTANVPPQQEEWARERQEAVQEALSPRLPAELQNMVAQDIPEACMTLEDAKEYRLELMDERRSKQDAQNAAFETGDFGLCEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW64</accession>
    <name>A0A317VW64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="11">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="11">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_537768</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464883.1">
        <property type="nucleotide sequence ID" value="XM_025612348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW64"/>
    <dbReference type="STRING" id="1450535.A0A317VW64"/>
    <dbReference type="GeneID" id="37114491"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00056106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY78574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="287" mass="31928" checksum="886FF2EDE0F88046" modified="2018-10-10" version="1">MAYDPRLPSAGTATTPSPPPPPPPPPETMRAPQPQPTASNEATPIPDSESYKLRFCTVCASNQNRSMEAHLRLSTAPSPFPVISFGTGSLVRLPGPSITQPNVYNFNTTSYSQMYDELFSKDERLYRNNGLLNMLERNRNLKWGPERFQDWVPGQPRVDHVSKGDKGALGTEGGVVDVIITCEERCWDAVVDDLMNKGSPLNRPVHVFNVDIKDNHEEALVGGKAILELANRLNDAASTERKSNGSEGWENGMGEARRNFDARVPEILAEWQEKWPHLPALWTLAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWC4</accession>
    <name>A0A317VWC4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_522557</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464587.1">
        <property type="nucleotide sequence ID" value="XM_025610188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWC4"/>
    <dbReference type="STRING" id="1450535.A0A317VWC4"/>
    <dbReference type="GeneID" id="37112331"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="496" mass="56291" checksum="8ECE47272E8CD5B6" modified="2018-10-10" version="1">MYTLILLSVVYLFARTIYRIYFHPLSKIPGPKLAAATHLHEFYHNVIRGGKFIWEIENMHRLYGPIVRINPREVHISDPSMYDEIYAGGGRKREKDTGLVSSYASSYAALATIDHDLHRARRAPLNPFFSKKSVSELSDVLHEKISLLSRHLERAHAERTRITLSTALIALTGDIITHYLYGQDNGYLKDRDLAKRNMVWEIMAEGTSACHLFRFFPCIPTLTKALPGRLMRLIRPALSNVYDMQEQIAHQSEEAISSHGSLKLRTIYHALNDPSVPASERSLARLRDESFIVLIGGTESTAATLTFAIYHLLQSKNMYLKLRQELQQLMPTATSEANWSQLEQLPYLTAVVNEALRLGSAALRPARVAPTETLYYQGHSIPPGTPVSTISYFIHRNPAIFPNPESFNPERWIQAAERGDNLTRYLVPFTRGSRICIGMNLAYAELYMTLASIVRRFDLEICGTCPEDMEFAREMVVQRPEKGVWTLDVRVAGVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VX02</accession>
    <name>A0A317VX02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_537905</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464631.1">
        <property type="nucleotide sequence ID" value="XM_025612376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VX02"/>
    <dbReference type="STRING" id="1450535.A0A317VX02"/>
    <dbReference type="GeneID" id="37114519"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="101"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="200"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="304"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="382"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="756"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY78119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="856" mass="96809" checksum="5FD565067348A9F7" modified="2018-10-10" version="1">MVHRLLQCALGRRDVDDRDHFGKKRLDLAGPLLANLFRVLFTRVTRDLQRYVQRCVETNREIYLNIGIKASTLTGGLKYALATGNWGEQKKAASAKAGVSQVLSRYTYASTLSHLRRTNTPIGRDGKIAKPRQLHNTHWGLVCPAETPEGQACGLVKNLALMCYITVGTPSEPIIDFMIQRNMEVLEEFEPQVTPNATKVFVNGVWVGIHRDPAHLVNTMSSLRRRNMISHEVSLIRDIREREFKIFTDAGRVCRPLYVVDNDPKSENCGSLVLNKEHIRKLEQDKDLPPDLDPEDRRERYFGWDGLVKSGVVEYVDAEEEETIMIVMTPEDLEISKQLQAGYALPEEELHDPNKRVRSILSQKAHTWTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVFLTNFDQRMETMANILYYPQKPLATTRSMEFLRFRELPAGQNAIVAIATYSGYNQEDSVIMNQSSIDRGLFRSLFYRTYTDSEKMVGLTVVERFEKPMRSDTIGMRKGTYDKLDEDGIIAPGVRVSGEDIIIGKTAPLAPEAEELGQRTKAHTKLDVSTPLRSTENGIVDQVLVSTSNDDLKFVKVRMRTTKIPQIGDKFASRHGQKGTIGITYRQEDMPFTREGVCPDLIINPHAIPSRMTIAHLIECQLSKVSSLRGFEGDATPFTDVTVDSISRLLREHGYQSRGFEVMYNGHTGRKLVAQVFLGPTYYQRLRHMVDDKIHARARGPTQILTRQPVEGRARDGGLRFGEMERDCMIAHGASAFLKERLFDVSDPFRVHICDDCGLMTPVAKLKKGLFECRLCNNKHRISQVHIPYAAKLLFQELASMNIAARMFTNRSGVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VX34</accession>
    <name>A0A317VX34_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Riboflavin synthase</fullName>
            <ecNumber evidence="4">2.5.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_523598</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dismutation of two molecules of 6,7-dimethyl-8-ribityllumazine, resulting in the formation of riboflavin and 5-amino-6-(D-ribitylamino)uracil.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.9" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464293.1">
        <property type="nucleotide sequence ID" value="XM_025610224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VX34"/>
    <dbReference type="STRING" id="1450535.A0A317VX34"/>
    <dbReference type="GeneID" id="37112367"/>
    <dbReference type="OrthoDB" id="10258924at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004746">
        <property type="term" value="F:riboflavin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000004">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000006">
        <property type="entry name" value="Riboflavin synthase, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006767">
        <property type="entry name" value="PRK09289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098:SF0">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="RIBOFLAVIN SYNTHASE ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="9">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="10">
        <location>
            <begin position="104"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY76480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="234" mass="25156" checksum="ABF19FF973750CFD" modified="2018-10-10" version="1">MFTGLVEKIGTVSSLEPLDTSSSGGGGTSLTITDCEEILTDIHLGDSIAVNGTCLTVTAFTPTSFKVGVAPETLRRTNLGSLTTNSPVNLERAVLGETRMGGHFVQGHVDTIAQILSVTPDSNALVFRMQPRDLGVMRYIVEKGYVTLDGASLTVTKVVDGAEGFFEVMLIAYTQEKIVTAKKKVGEWVNVEIDIVGKYVEKSVQGYFAGTGAGGDMKMLEKMVERIVEEKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXS4</accession>
    <name>A0A317VXS4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphate 2-phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_471909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464748.1">
        <property type="nucleotide sequence ID" value="XM_025608404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXS4"/>
    <dbReference type="STRING" id="1450535.A0A317VXS4"/>
    <dbReference type="GeneID" id="37110547"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="126"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="249"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY78439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="667" mass="74953" checksum="F504B9BAF26BB04F" modified="2018-10-10" version="1">MSQHTDIARSAIMTCASIPEHQRGASGKTNGAVSHSGPGKEANLMPPPKTLVGRALGNELHSDAHKGSQAPKDGVGFALTDTPVSTAPSSPQFTANTTPSTPGRVRATTLDIPGLTKSKVSPDGRIAQRDVGSKLVIVMVGLPARGKSYVTKKLARYLNWLQHDTEIFNVGERRRVAAGKSPAVAGRRPSHRANAVTSPPELENKLPPPAVPTKILVNGKEEDPSQSTIVPPMNASPAEQDAIREASPEPIDQSASFFDPKNQLAVKLREQVALDTLDELLDYILEQSGSVGILDATNSTMERRKAIVDHIRNRAGPELNILFLESSCVDPELLEANMRLKLSGPDYKDQDPVKALEDFKRRVALYEKSYVPLGEYEEKHNMAYIQMIDVGRKVVSHQTHGFLSSQVVYYLLNFNLSPRQIWITRHGESKDNQAGRIGGDSELSENGHRYAQALNRFIDHQRQQWELVQRQKEMLRHLPPRAGDSTPPNPSYIPRDRPRNFCVWSSMMQRSVQTVDYFNEDEYDVKQMKMLDELYAGKMEGLTYDEIRDKFADEYAARRKNKLYYRYPGPGGEGYLDVINRLRAVIIEVERTTDHVLLVTHRSVARVLLAYFRGLKRDEVASLDVPLGMLYMLEPKPYGVEFKAYRYNPTTDWFDYIPDFKLQQTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYL1</accession>
    <name>A0A317VYL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_186654</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464614.1">
        <property type="nucleotide sequence ID" value="XM_025606013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYL1"/>
    <dbReference type="GeneID" id="37108156"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY78102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="525" mass="56641" checksum="A6ED541F5D0BE2D1" modified="2018-10-10" version="1">MPSSFKPDESEPVLATLESTPTSPDPNAAAASYRHKADLLNRAIQDIGMGKYQWQLFGVIGFGWASDNLWPIVTSLILVPVSYEFHVAQPPLLSLAQNIGLLAGSLFWGFTCDLFGRRWAFNLTIAITAVFGLVAAGSPSFAVVGVFAALWSFGVGGNLPVDSAIFLEFLPGSHQYLLTVLSINWALAQVLANLVAWPLIGEMTCSSAENCSRSTNMGWRYFLITMGGLALFMCLARWVFFTLFESPKFLMGKGRYEESVSVIHEVARRNGTTSSLCIDDLLDECTTSGTGTTATSTPTVPTPRHGLSAADQLRMRLEPLTAPYVRALFSTPRRAWTTSLMIFIWALIGLGFPLYNNFLPYLQQTRGIQFGDGSTYITYRNSLIIAAVGVPGSLVGGVMVEMPRFGRKGTLSLATLLTGAFLLASTSATTSAALLGWNCAYSFTSSLLYAVLYAYTPEIFETQHRGTGNALVGGANRIGGILAPIIAMVANVQTSVPVYISGGMFLLAGLLVLLIPYETRGKMSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYN7</accession>
    <name>A0A317VYN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_537859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464589.1">
        <property type="nucleotide sequence ID" value="XM_025612367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYN7"/>
    <dbReference type="GeneID" id="37114510"/>
    <dbReference type="OrthoDB" id="5366688at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="20878" checksum="9E57840D4F14DCC2" modified="2018-10-10" version="1">MAPFGLLGATFLCARIIQLCSLIAIIGLTANFIAEIVSNSASPPAIFIGTITVTSIAAIYAFITTILFVDNILPFLATAILDTLILIAVIVVSVIIGKPLSYLQCNNIENYATSDGSSAYTFSTHLSNYLDDLSGKVDYTSWIGGTKAVCLEAKSIWGLCIAMCIMFFFSGICGLVLWRQKKAASAGVEKLEGRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W002</accession>
    <name>A0A317W002_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L27a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_521498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464907.1">
        <property type="nucleotide sequence ID" value="XM_025610150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W002"/>
    <dbReference type="STRING" id="1450535.A0A317W002"/>
    <dbReference type="GeneID" id="37112293"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_uL15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="9">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY79335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16717" checksum="4DA173F594CC2471" modified="2018-10-10" version="1">MPTRFSKTRKARGHVSAGYGRVGKHRKHPGGRGMAGGQHHHRTNLDKYHPGYFGKVGMRYFHKTQQQFWKPTINLDKLWSLVPAEKRDAYLSGQKTDTAPVIDLLPLGYSKVLGKGRLPEVPIVVRARYFSRDAEEKIKAAGGVVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W0R8</accession>
    <name>A0A317W0R8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_537521</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465061.1">
        <property type="nucleotide sequence ID" value="XM_025612290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W0R8"/>
    <dbReference type="STRING" id="1450535.A0A317W0R8"/>
    <dbReference type="GeneID" id="37114433"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000030">
        <property type="entry name" value="Sorting nexin-3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY79489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="142" mass="16755" checksum="0ED781E0D00FA5EC" modified="2018-10-10" version="1">MQAVPESRQQTFEEIYGPPENFLEIEVRNPQTHGTSRNMYTSYELVCRTNIPAFKLKHSVVRRRYSDFEYFRDILERESTRVTIPPLPGKVFTNRFSDDVIEHRREGLQRFLQIVAGHPLLQTGSKVLASFIQDPNWDRNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1K0</accession>
    <name>A0A317W1K0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_157383</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465212.1">
        <property type="nucleotide sequence ID" value="XM_025605847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1K0"/>
    <dbReference type="STRING" id="1450535.A0A317W1K0"/>
    <dbReference type="GeneID" id="37107990"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF178">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY80353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="570" mass="63064" checksum="DA3698A9FFFD3294" modified="2018-10-10" version="1">MPIFKDRDLDVPGTELLIDVQHDLDVAHDSSDIILLPPPTACEGDPLNWSKFKKYWHLFLVSAYACVFSFAENNTGDAYSTIVDMTGSTMTIMNGGGALNYLMLGLVNIFWIPAAMKIGRRFCFLATLLLCIGSSIWMGAFHTAGEWYGCNIVNGLGTSAYEAVIQLAVFDLFFDHQRGRMLGFYIFAQQLGSIIGLVSGGYIADGPGWRWAQWVVAIGEAVLIIVFYFSYEETLFPRFLFTSQSLPTEEAKTISPVEATETASVDKKDRIVVDNASVSEGTASGTIPSPSEFPKRTFSQKLRLWVYYPQDKTTYWSYFKRPFFLLAFPNIIIAGIIFAFGCTSGIVTNKTISEILTGAPYNFTDGQTGLAYLSALVGSIIGYLTSVMGDKIVIYLARRNDGVKEPEMRLWALVPCFIYTALGYELYGWGAQEGAHWMTITVGIGAMIAQQVAATSTVCSPSICLARPSHSSKLTMHLQATAYAMECFPGVGGEIVVILAICSSIINFIISETTQPFYDTTGPGWLFLFYGIWVILSLVAGMAVYVWGKKWRRKCAPRYYKFLQERGGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2G3</accession>
    <name>A0A317W2G3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Siroheme synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_537486</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Siroheme synthase involved in methionine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32459"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.107"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465034.1">
        <property type="nucleotide sequence ID" value="XM_025612283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2G3"/>
    <dbReference type="STRING" id="1450535.A0A317W2G3"/>
    <dbReference type="GeneID" id="37114426"/>
    <dbReference type="OrthoDB" id="508204at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000504">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000005">
        <property type="entry name" value="Uroporphyrin-III c-methyltransferase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012066">
        <property type="entry name" value="Met1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036555">
        <property type="entry name" value="SUMT_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="15">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="14">
        <location>
            <begin position="227"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="13">
        <location>
            <begin position="283"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY79462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="555" mass="60460" checksum="8A279B6F96214B08" modified="2018-10-10" version="1">MRDASDSGSLAPLLTAVNVESHVHLIIGSNPLAAARCAKSIEAGAEPVLIAPDTEELQYTLVERIENDSVKWIRREFEGADLTSLGREEVDCVVDMVFVTLGGNNPTSAHISKLCRRLRIPVNVSDAPDLCTFSLLSTYSDGPLHIGITTSGRGCKLASRLRREISSGLPSNLGNAIDRLGAVRKRLWAEDYAAGLCDAPLEGDEDDSTGQRHTFNTLVTEDDISAARTRRMRWLSQICEYWPLRKLAAITDEDINAILEAYSSGKEGPKDIGGRESLSKKGKIVLAGSGPGHPDLLTRATYNAIQTADIILADKLVPAPVLELIPRRTEVHIARKFPGNADQAQEEFLKMGIDSLRRGRHVLRLKQGDPYLYGRGGEEFEFFRAEGYTPVVLPGITSALSAPLFADIPSTHRGVSDQVLICTGTGRKGAAPEPPTYVPTQTVVFLMALHRLSALIESLTTEPAEGFRPRIPWPRDTPCAIIERASCSDQRVIRSTLEHVSAAFEAEGSRPPGLLVVGASCHVLHPAQGQKWVVEEGFRELDELLTEATCRDEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2W2</accession>
    <name>A0A317W2W2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_180223</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464839.1">
        <property type="nucleotide sequence ID" value="XM_025605972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2W2"/>
    <dbReference type="STRING" id="1450535.A0A317W2W2"/>
    <dbReference type="GeneID" id="37108115"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="715"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="786"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="919"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="715"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="800"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="930"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="972" mass="109759" checksum="65BAF50B62B01F25" modified="2018-10-10" version="1">MQNPKLAAGFSPSWRVQDNPLIPQKSAASNGHDLGIRRRNPLACEACYKKKIRCEVEGSNATCIQCLRRNTACKFTSRKEKREDLKRTHYVRTLENRVRQTESILRAAGLFSDDLMSLDDEPSEEDEDKKVDSRSDSEEESISPYFSPREVSSRRSSAVLTSPGSRDSDHPQFRAPTGGDAGNRSDAADARQSIGPSNLSSVPEGGCSTSQVCAHTHAPVFKMDSREDSRYYGRSSFLSILSREALEWIQSKTGEAKPLSVVFSDSSRDNAWDAWRPEVFHDLFASQVFKPLPPRAEVFTLLRDYFRTVNRLFPLYHEPTFMQLVEWQYTQQTCDDAARWASINIILSLAYEYRFSNCQKSEKDRERAWLYYKNAMSVFAELSLRRTDLLSVQALLGMAFFLRGNSGTQSALPIITAAMRICQRMGLHRDIPRPYLTPVEQEQRRRVFWIAYILDQSSCVRSGSAPAQHYEDFDVDFPAENSGDAFVKARDSSFFRQLCQLTLIKSRVFSKLYSAKALENKAPEEIYDNIRELHEELEEWKRVNSFEFRMKQRGAGEDFLIGFASAGLQFVYYNTMIMIHRLPLMIQFASAHYIAKGDPPPMDHDLIMREATASSAVCVQAARDTVRLVNNLPWGDIAWIWSLLYYIFLAVMNIFVSILREPHDEKAKDDLQSLNMAATFFATLIPGDGPCHYARFMTKMCANFERVARAVLERTQKAVKPETKRHSASRTNSTSTKPTRSTSPNPSHTTTHHKSHSNPPSSSPVYSMNIDIPNLEGLPPVNSSGYVIPDNLSPSPTPEPTLSLPATTIPTQPLSQPPPPSQPYNTTTTSTTPYNLQSTFFPITVNSDGFNFSQPELWQIPLTADWEITPQALGNLFGPDLNYIFPEQMGTTGGNGFQPQPQPQHQPQLPTQPMAMAPAPMEFAYGGPMPQTQNPNQTRTRNQQHTGTGQQMQLNGMWMNGTTYSNPYNFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6J0</accession>
    <name>A0A317W6J0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MAK16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_548218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the MAK16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465534.1">
        <property type="nucleotide sequence ID" value="XM_025613387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6J0"/>
    <dbReference type="STRING" id="1450535.A0A317W6J0"/>
    <dbReference type="GeneID" id="37115530"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="6">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY80932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="328" mass="38096" checksum="F176EA3131E0F335" modified="2018-10-10" version="1">MSSDEIVWQVINQQFCAYKLKTTKNQNFCRNEYNVSGLCNRQSCPLANSRYATIRSDPETGAMYLYMKTVERAHMPSKWWERIRLSSNYAKALEQLDERLIYWPKFLVHKCKQRLTRLTQVAIRMKKLAKEDERLGEAVVAKLAPKIRRREEARERKAESAAKIERAIERELIERLRSGAYGDRPLNVEEGIWKKVLRGLERSGEGERDEDLDDGEEIEEEEEDEEGVGQVEYVSDIDEDDEDLEDIEDWIGGESGDSSDDYDESEEDENSEDDSEEDDSHHSEEESKKPKPGFKRKRPAPQIKPRKKGPRVEIEYETEGPGKESVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W961</accession>
    <name>A0A317W961_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nonribosomal peptide synthase Pes1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_547648</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465939.1">
        <property type="nucleotide sequence ID" value="XM_025613342.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W961"/>
    <dbReference type="GeneID" id="37115485"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904091">
        <property type="term" value="F:non-ribosomal peptide synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000024">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000016">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000017">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000031">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000037">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000010">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000003">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000014">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45398:SF1">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="15"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="787"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="3391"/>
            <end position="3467"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="4490"/>
            <end position="4566"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="5565"/>
            <end position="5641"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="6149"/>
            <end position="6228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="5546"/>
            <end position="5569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY83154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="6281" mass="696461" checksum="3789EE1350060DA5" modified="2018-10-10" version="1">[encoded data, 6281 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9T1</accession>
    <name>A0A317W9T1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_536593</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1 9">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465898.1">
        <property type="nucleotide sequence ID" value="XM_025612048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9T1"/>
    <dbReference type="STRING" id="1450535.A0A317W9T1"/>
    <dbReference type="GeneID" id="37114191"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 8 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="141"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="267"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="350"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY83113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="454" mass="49440" checksum="F6880FD171AED040" modified="2018-10-10" version="1">MDDIPSTTPDEAVRLSAKRTTEIFGPDYLMVTPSAGNGSIGLSYRRKAEYADVKELPPALAEKQAKAVAAGRAKRPKIQPQPQTAAADSSGASMALVKKAPGLAAGGVGGENAPKSLIQRPSATKQQRPDWHPPWKLMRVISGHLGWVRSLAVEPNNEWFASGAGDRTIKIWNLATGALRLTLTGHISTVRGLAVSPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYTLDLHPRLDLLVTGGRDGVARVWDMRTRSNVHVLSGHKGTVADVKCQEADPQIITGSLDATVRLWDLAAGKSMGVLTHHKKGVRALATHPREFTFASASTGSIKQWKCPEGDFMQNFDGQNAIINTLSANEDNVLFSGGDNGSMCFWDWKTGYQFQSIESTAQPGSLEAEAGIMASTFDRTGLRLITGEADKTIKIWKPDDEATEESHPVTWAPTLGRQRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WA79</accession>
    <name>A0A317WA79_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_587175</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Golgi apparatus membrane</location>
            <topology evidence="2 9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466068.1">
        <property type="nucleotide sequence ID" value="XM_025615805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WA79"/>
    <dbReference type="STRING" id="1450535.A0A317WA79"/>
    <dbReference type="GeneID" id="37117948"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016190786" description="Protein kish" evidence="9">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY83283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="73" mass="8167" checksum="E18F6D7F52701C8E" modified="2018-10-10" version="1">MQSALFNFQSLLLVFLLIICTSTYAHSMMPGIMDRNQSGFFGIFWKCARIGERLSPYVSICCVVMAVSIFFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WB39</accession>
    <name>A0A317WB39_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_536614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465920.1">
        <property type="nucleotide sequence ID" value="XM_025612053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WB39"/>
    <dbReference type="STRING" id="1450535.A0A317WB39"/>
    <dbReference type="GeneID" id="37114196"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="66"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY83135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="277" mass="31044" checksum="30226D7478A425D9" modified="2018-10-10" version="1">MPRKSTSSTPGDEHPPTTQSPSPHPHQPPNPVQLPESQGQMVEATEQQIKARASIEDYLLPRSLTLRLAKSVLPPNTSIQKDAVLAIQKAATVFVSYLSSHANEATLKRTVAPSDVFSAISELEFDGFRARLEKELEAFTELKAGKRRAKKGEEEPGKEVGEEEEEEEEKDRGAKRVKRGVEKKGEEKQEDGDETQEEQEVVGNETEEEEEEEEEEEDEEEEEEHKDEEENDIDRVEDLDRDARAKRLMNPDVEGDESDSEDEDGPGSQLRGDLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDL2</accession>
    <name>A0A317WDL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465933.1">
        <property type="nucleotide sequence ID" value="XM_025612059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDL2"/>
    <dbReference type="GeneID" id="37114202"/>
    <dbReference type="OrthoDB" id="5397330at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="238" mass="26151" checksum="2CCC6275FDD93668" modified="2018-10-10" version="1">MAPFRNFLSRKSAAPNGGEVSAASNDSTLSHVSLETHGSTSVSFRKSSENEPPEYKLSVVDANGIYHPPSPPEKPGFWRKYPGSPRSSHHRDLVDENEPFSISRESFDSYRRSFDISARSPVCYSDAMPSRTSLDSRVSRMTSPPSTLYTGLGKQPETMEEEQFEEVGLDDEEVKPKRKSIFSRFGDFTSDSQNSGTSKTSSLGFHIPGRKRGPSTVGSELGTFKAPPANAESEMQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE31</accession>
    <name>A0A317WE31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">BAR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_468292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466651.1">
        <property type="nucleotide sequence ID" value="XM_025608239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE31"/>
    <dbReference type="STRING" id="1450535.A0A317WE31"/>
    <dbReference type="GeneID" id="37110382"/>
    <dbReference type="OrthoDB" id="5549748at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07600">
        <property type="entry name" value="BAR_Gvp36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018859">
        <property type="entry name" value="BAR_dom-cont"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10455">
        <property type="entry name" value="BAR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAR" evidence="3">
        <location>
            <begin position="433"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="614"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY84726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="728" mass="84486" checksum="5AEF9964185B3214" modified="2018-10-10" version="1">MSRHGDYRRSTGALNEDHYSRERHRHRHRSRGPPVLDRPRRVEEDDRFEYRLKEEERYGPPARRSDVFYKDGHLVYPSGPLVIHERRHADSPPPRPRLLRRQSSLDTFDRVPSRKIDEYYYSDYPPRAAPSPPPMRRRGSFHRAREPDYYEEIRIAEPEYYGDEEYREFRERERIVERPRRSMSRYRERMVEEVDVEKPYPRRGKTRMPRKLVHTSAIREFGYPYEEEGKMLIIQVALSKEQIDAVIGRSREIKHMTETRYKHTPSPSPVRERRRDRTVERIAMESYTPRTSHETLLIEPSPSRRRSHSRHPRHHHDELSEKKVTRTVSRTRTLSVQGRPRRRSSPVPRIERYDDGVHFSKVQSGPLAIVVRPRDSDDDLREYAQIERRGGGEVIRTTDIIGDGEEEEITEVRRDRRANSSRIMDKFQAFGKNLSASFSPFAARTQQMIKEQLGQAEDRTQLPDEYIELEKRVDALKIVHQKLLQVTSQYSNEAYDYPPNIRESFNDLGRTINEKVTLLSQASSPAEAQAALTAPPSAKPQPKTFNHAIARASLAGSQTLAQNSRNEDPLATALEKYALAEEKVGEARLAQDAQIQSRFLAGWNTTLNTNLMFAAKARKNVENARLMLDSVKASKKAAAKGDWDNLSEEARQEIEQAEDEFVGQTEEAVSVMKNVLDTPEPLRNLADLIAAQLEFHKRAYEILSELAPVVDGLQVEQEASYRKSREGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEP2</accession>
    <name>A0A317WEP2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_468252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466420.1">
        <property type="nucleotide sequence ID" value="XM_025608236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEP2"/>
    <dbReference type="STRING" id="1450535.A0A317WEP2"/>
    <dbReference type="GeneID" id="37110379"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000354">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="75"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY84495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="519" mass="56459" checksum="947CD01D187B1EDF" modified="2018-10-10" version="1">MFDQKFLTSSSTLVVPNAGHQGFRSDHRPPLNSTITLIQATTRESDQTLPQEENNSREVDASQYTRLSPARKIIIVVILSYCAILGPISSTAILAAVPELARTFNTTGDIINASNALYLAFMGIAALLWGPLSQISGRRPIFITSSILFFLFTVATALAPNIEAYFVFRICTAFQGTAFLVLGSATVGDIFEPMSRALPLGWVLSGTLTGPALGPFLGGVVATFRPWRDIFWLLAALNGFAAVLIIVVFPETIAHKSDAQLKGKTFPQKAKQLGSHICPIRIARLVFSYPNIFLASLAAGTLVWNQYALLTPIRYILNPRFHLTTPVEAGLFYLAPGSGYLAGAFVGGRWADLVARKYARIRNGQRIPEDRLRSCVPFICIATPACVLVYGWTVDREVGGVPVPVISMFLQGVATMFCFPSLNTYGLDVMQEKGRSEEVVAANFVFRYVFAAVGTGVVLPAVQALGVGWFSTISALLLTAVGGAVFLIAEYGHRWREAVDAKLQAKEDTKWENKSQAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WF21</accession>
    <name>A0A317WF21_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="11">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_599223</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466295.1">
        <property type="nucleotide sequence ID" value="XM_025616304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WF21"/>
    <dbReference type="STRING" id="1450535.A0A317WF21"/>
    <dbReference type="GeneID" id="37118447"/>
    <dbReference type="OrthoDB" id="157622at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000131">
        <property type="entry name" value="Probable alpha-L-arabinofuranosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015289">
        <property type="entry name" value="A-L-arabinofuranosidase_B_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038964">
        <property type="entry name" value="ABFB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007934">
        <property type="entry name" value="AbfB_ABD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39447:SF2">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05270">
        <property type="entry name" value="AbfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09206">
        <property type="entry name" value="ArabFuran-catal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027154152" description="Alpha-L-arabinofuranosidase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B catalytic" evidence="13">
        <location>
            <begin position="20"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase B arabinose-binding" evidence="12">
        <location>
            <begin position="406"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="10">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="10">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="81"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="401"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR638964-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF09206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY83827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="473" mass="49431" checksum="1015EDA24C77D95E" modified="2018-10-10" version="1">MFSRRSLIALGLVATATAGPCDIYADGDTPCVAAHSTTRALYSSFSGALYQVKRGSDNETTTISPLSAGGVADAAAQDTFCANTTCLITEIYDQSGNENHLTQAPPGGFDGPDVDGYDNLASAIGAPVTLNGQKAYGVFVSPGTGYRIDKGNGVATGDEAEGMYAVLDGTHYNGECCFDYGNAETSNTDTGAGHMEAIYLGNSTAWGYGAGDGPWLMVDMENNLFSGADEGYNSGDPSISYRFLAAAVKGGPDEWSIRGANAASGSLSTYYSGVRPDYTGYNPMSKEGSIILGIGGDNSNGAQGTFYEGVMTSGYPSDATENSVQANIVDAGYAVTSLTSGPTLTAGDTISLRVTTPGYTTRYIAHTDTTVNTQVVSSSSSTTLQEEASWKVVTGLAYSGCFSFESFHEDATFCPQAALNGEGTSLRSWSYPTRYFRHFDDVLYAASNGGVQTFDATASFNNDVSFEIYTGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFX6</accession>
    <name>A0A317WFX6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_118231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465875.1">
        <property type="nucleotide sequence ID" value="XM_025605555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFX6"/>
    <dbReference type="GeneID" id="37107698"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016360518" evidence="1">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="52" mass="5560" checksum="9850C6BEA723C290" modified="2018-10-10" version="1">MDTRGFGQFAVWFSCISGTFSFKLLLPADSLDGLIALVSSTASLPSSNKVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WGT3</accession>
    <name>A0A317WGT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_467759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466691.1">
        <property type="nucleotide sequence ID" value="XM_025608221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WGT3"/>
    <dbReference type="STRING" id="1450535.A0A317WGT3"/>
    <dbReference type="GeneID" id="37110364"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="139"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY85674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="420" mass="46611" checksum="976C717E93047540" modified="2018-10-10" version="1">MHTFSKLSTTSSAAKASQGQGVDKVNENANAKKNGSDPKKSSQKQQKNQRPVVPFGRKDRILLVGEGDFSFARSLVLQHRCKNVLATCYDSKESLYGKYPKAEHNIHDILDASLKRTTYADVLGSKDNSTKGSDEGLNSEDDIEKHDAQDSIENQTQSRGPKVLYAVDARKLGLPAGGGKEIRTGFSRRERKRPAWKEAKNGVSSSASQGGSWDVICFNFPHVGGLSTDVNRQVRANQELLVAFFKACVPLLSHRPEIAGSDDEEDWDNWENPDIETSQDEGDGDGESNQLRSANTTGQATCCTRIEPGQILVSMFEGEPYTLWNIKDLARHAGLRVITSFRFPWACYKEYSHARTLGDIEGKHGGRGGWRGEDRDARMYVFEVKQEDHPVGRRNVPSSKLETSARKKRSRDASDSDDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WGX9</accession>
    <name>A0A317WGX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_536078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466447.1">
        <property type="nucleotide sequence ID" value="XM_025611935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WGX9"/>
    <dbReference type="STRING" id="1450535.A0A317WGX9"/>
    <dbReference type="GeneID" id="37114078"/>
    <dbReference type="OrthoDB" id="5354320at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF25">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="156"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY84522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="491" mass="54186" checksum="27760F0CF7B1B1AE" modified="2018-10-10" version="1">MSKLENPLRLLMAVLMRVPLILKTILLHGIRLSPVTGKQDLRTELTVAIIRSIIVFTSPVGKQQKDSLRDPGIRGPMWVSKVTFPRPENNVQDAVIKAIEDLKVGDETYNIPGVVPVEAEWTGYRSGVGKNAPQPNISEEAKYEELRKESKGDMVILYLHGGAYFLMDPCTHRPVVTQLSKRTGAPVLSVRYRLAPQNPFPAALIDALVAYLSLISPPPGSLHDPVPPNKIIFSGDSAGGNLCFVLLQTLLTLRRVCPTVHFHGRDIPIELPAGVATISPWCDVTRSMPSVTHNSVYDFLDPPSQNPEVAYRPLAVPEDDVWPVKPPRVDLYANANALLHPLVTPIAGRQEIWKGAPPIFIAMGEEGLSDEGLVLARKMHRVGVPVIVEQFEGMPHCFGMIMMGAPASRRLFDSTAQFCRDAVAGNLTAAIPTSGNVTFIGYKLRYTHEIPLEKAVPLTDEEVDEVLEKNAQWRLEGEKELEQEWLGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHZ7</accession>
    <name>A0A317WHZ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_535789</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466682.1">
        <property type="nucleotide sequence ID" value="XM_025611864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHZ7"/>
    <dbReference type="STRING" id="1450535.A0A317WHZ7"/>
    <dbReference type="GeneID" id="37114007"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY85665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="89" mass="9946" checksum="91B4F0E8E6E8AE8A" modified="2018-10-10" version="1">MDAQTQVDVTKLNEADKKELSQILASETQKATIQQTVHSLSDVCWKKCITGKITSGRLDQAEETCAQNCVERWMDANLTVLKHLEALRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMT3</accession>
    <name>A0A317WMT3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BO94DRAFT_80380</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">GPI-anchored chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Required to reshape the cell wall at the sites where cell wall remodeling and/or cell wall maturation actively take place such as sites of conidia formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466958.1">
        <property type="nucleotide sequence ID" value="XM_025617676.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WMT3"/>
    <dbReference type="GeneID" id="37119819"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000150">
        <property type="entry name" value="Class III chitinase ChiA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF47">
        <property type="entry name" value="ENDOCHITINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="16 20" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="10 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 22" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016384750" description="chitinase" evidence="22">
        <location>
            <begin position="22"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="23">
        <location>
            <begin position="28"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="338"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="653"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="740"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="800"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="873"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1174"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="349"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="800"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="816"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="873"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="909"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="951"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="1185"/>
            <end position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PWY86367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1291" mass="126715" checksum="735301E24645BB5E" modified="2018-10-10" version="1">MVSNLFTIATAVAGFAPFVSAFDAQAKSNLAIYYGQGYAQQRLSHFCQETSLDIINIGFIDVFPDQGKGGWPGSNFGNQCDGLTYQVDGVSTQLLSGCHQLVEDIPICQAAGKKVFLSLGGASPDDYKILSEDSATSFADFLWGAFGPKTDSWTLNNGPRPFGDVVVDGFDFDIEHNGGFGYATMVDRFRQLFALVPERTFYISAAPQCQIPDAQLSDAIATSAFDFIWVQFYNTAGCAASDFVDGVSTGFNFDRWVNVIRQGGNPDAKLYVGLPASTSAAGASFYLTPEEVYPLVDTYMGLYPDTFGGIMLWEATASDENRFGNGTFADKMKDILLELDPTPEPTPSPSSSVVASSTPVATSTPTTTSTPTATNTPSASSTSLATSTPSASSSSGLSSTPESSSASASSSPVASSSVVVTSSVVAPTSVVAPTSTVTSGSAVASSSVTSSSVASSSVVTSSSVVTSSPVASSSVTSSSVIASSSAVSSSSVVSSSVVSSSVVASSSVVAPTSVVTSSPVASSSVVAFSSVTSSSAIASSSVVSSPAVAPSFIVTSSTLVASSTLKTSSSPIASSSPVVSSSSVAPISPVVSGTLTLSISPSVSSTPIIPSSAATSSSAVALTSPASSAPVLSGSTVTLSTPVASSSALSSSLSASSTPVKSGSSVVPGSSTPSSSPVRSTPPVATGKSSSAPVISKSSSTVVATLTTSSGSLTSSGIVGVSATSSSTLAQLSSTLSLSSSSVASGEPAPSGSAVGSSTASASSAPGNTTYSISTTQTIVATQSSSSVLSGQPISSISGTTTLPVTSSPSEPTNPTAASSITTGSADASSSSSIASGESTSSELVAPVTSSSTSYVSTSSSPVVTTGLPISSGISSSSVNPSPSSSGTESTGSASGQAGALTTHKPSGGSETSSTPNSSGATSKGSGAQESSSATDHASTLSPSYTALPVGTSSGQTDSPTTSPTSVPGGNGSGAAPITSSITSGHGALPVASSGSVSEPVSTTTVIVTSYIDICPEGFTTITTSYTSTYWPATVSATATVTKPPGIPAQATIPSVPEGWTTTVTVCTHCAPTPTTVTLTLPATISSSGLASSAKAPSTGEGWTTTVSVCTDCGPTPTTVTLTLPATNLPSGLASSTQAPHSGEGWTTTVSVCTDCGPMPTTVTVTIPVGSATGIETPSVKPSGVQLTGESSPGQTAPPALVSTAVTTSTAVVPPSHSSSSRPVILGTGGVRASSTLHIQPSQSGSRVPTAPSGMPEGVSPVFTGAASRGSELRHGAGAMTAFALFLLATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNS4</accession>
    <name>A0A317WNS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_465866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467907.1">
        <property type="nucleotide sequence ID" value="XM_025608137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNS4"/>
    <dbReference type="GeneID" id="37110280"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="533" mass="59721" checksum="4226F2BDDBFED5D7" modified="2018-10-10" version="1">MVFPGRLSTGCYVCRRRKVKCDGARPACRRCITQHRECTGYPDAFAFRAYKLQPQAGKITTRKRGKKSAENDQSTSSPRIPSQTVLEQESTDTRLVLRNSSPPQPSPPAAITPCLEWQSLCYFFHQHVMPTQRSPCEGHLEFLPELYQEKGSDPCLRNAILSVSYLSLFNTARVNELYVNARKHYGMALKSLTAALSNKETSGQDETFAAALFLSMFMDLSGERQGEVNPHVPGICSLMHLRGRPERSSKYARKLFGWAFTQIQIQAIASNQFSYACLPASINMVYNPDYVLRSGIITSMISEFCQSASEFRRTEQYETLGTSARRLHSLLGRAYFIMEQISIWDEAVPKHWKHQLSVPTVDGMNQAEQAASRDPWTPCFLAVVQAAQIFFFLHVLECSDKFASVMFAIDDDHLENLPAETFSGLGNRIKSLIEVICSTVSYTLGHVTPTNEFKLHPNSKLANGYTLLWPMWVVVNCRLATAEQLTLCRRALECVGSTMGYRLASVLCMDSPDVSSTDILDTAPMTGHLAAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNS8</accession>
    <name>A0A317WNS8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_465265</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467869.1">
        <property type="nucleotide sequence ID" value="XM_025608105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNS8"/>
    <dbReference type="STRING" id="1450535.A0A317WNS8"/>
    <dbReference type="GeneID" id="37110248"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="245"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY88086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="596" mass="67087" checksum="E19BBD6C33FA28B7" modified="2018-10-10" version="1">MRQRIDHLEGLVRRLIGEGKNSSSPESVKGGTGGGASEASEVACVGSTVMDGVRSVYRGGDEWEDVLVEINSLKRTWTEAHDSRDEVVRPTLSHTVDGSSLLFGHVKPLERIEIMVTLPPKHQADKLIAQFFDRDNFPISLPPILHQPTFMREYDEHWENPSRTNFIWLGLLFSILGITMLSYHQFGEPPEYEGISESLFQLYRIRTSQCLLSGDIAKCLPYTVETLRFNATAELNRKDDNRRGLWIMTGVIVRAAINMGYHRDPSHSPSISPLQAEFRRRIWLSVISMDDMASFLGGFPRMSSAIYSDTREPHNLYDWELSESILPPSRPLTEPTAATYLIVKSRLFRAIGRIADFNNTPTLVSYDTVREIDQDVYTAYDNFPPHMKPSPHGIRKESLTSAAAISTLNLASMYHRSMCTLHRKFMARGRQDGQFQLSRDRSISSALALLSYQEALEPSWYKASQTRQMLILAAMIILLELELRTRLLDMDVSPDSTSLLQALERSCTLWENAKDSCDEASRIYGILARMVASSQNSSSSSSQSVTPPSGFDIPGFNTPVLVDGESFEKELASMDVDWATWDAFIQDTDFQGGPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WS70</accession>
    <name>A0A317WS70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_44254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467933.1">
        <property type="nucleotide sequence ID" value="XM_025607513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WS70"/>
    <dbReference type="STRING" id="1450535.A0A317WS70"/>
    <dbReference type="GeneID" id="37109656"/>
    <dbReference type="OrthoDB" id="4064873at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="173"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY88571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="572" mass="63169" checksum="13CF9FC5A00ABD62" modified="2018-10-10" version="1">MTRYTVYVGKAASLSFLQLVRDTVSQYIGPSQFSHNVKSEDMLETETPRDIPPAPDDTLDSYELLGYYRAYSSATSGFIYVLSDAEAMDILDGLINPSARRDKTKMALADMIIAIGAQSTKRAPSTEQAERFFFSRAQRSAFEGMLENPSLELVRLFLLMSFYMLGACRRNTAFMYLGVAVRAAVALGLHLTELVDAVPSPEQHQRAQVWMSVYILDLLVSSILGRPAATAALRSDAEHSFVRYTQPEGHMAMGLLASYKVSGILEEVIARMYSKEGASAEVAESLLAKLKQWSNGLPGPLVEPPNLDFEEPAARRQIIGNLHIACTYHFAVIIVTRPFLISVLGVRLARLHGGPVNWLSGDSLHEEPAHSNMATACTDSALYMIQTCSEVHRSGLLLGNMCILKAFVFAAGLVLGFSMFSRREADPPLDQAYKEALEILRVLSEQSAQAAHYSEILSYLGNAIAEQRQQLLHHSQQNKSRYVSKLFSLDDRRPSTEIRGGLETPARADISGIPPDSNISDSWVDLQRPNFMDSLDIGAAFTALDGMQLPVWDSFPFIGEPFQLQGRVNEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT61</accession>
    <name>A0A317WT61_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CST complex subunit Stn1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_534318</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468457.1">
        <property type="nucleotide sequence ID" value="XM_025611516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT61"/>
    <dbReference type="GeneID" id="37113659"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="5">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY89546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="217" mass="25853" checksum="D78B2AE1A5CA4E8E" modified="2018-10-10" version="1">MATADNNDLVFYPAFCFKASPTHFTWVKMAAVDVLRLKRRAEFQDQSTYFYNNHPIRFISLIGLIIARHELPTRSILTLDDSTGATIDIGTISTFRNKTQLQLERYFIIRDINTEMRFVDQRSRFLVEVLSVPWRLGGDEVERLRGEMEDEEELVEEEQERVRRRERRRVEREERDARRIQRGWEREERIRAKEAGCCRDAGVRVMREIEKRRGVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WU15</accession>
    <name>A0A317WU15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_534676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468134.1">
        <property type="nucleotide sequence ID" value="XM_025611605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WU15"/>
    <dbReference type="GeneID" id="37113748"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016357149" description="Secreted protein" evidence="1">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10169" checksum="6F5ED421EE4FE5BE" modified="2018-10-10" version="1">MVRYLLPGTSVPWLVPKSILLLTLRWLRFIHVINADENRSCSPVLLRSDDGTFVPDQVSKIRFRLVLTRSDAKGAMYTSLLIHWRSQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WU65</accession>
    <name>A0A317WU65_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_534613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468079.1">
        <property type="nucleotide sequence ID" value="XM_025611587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WU65"/>
    <dbReference type="STRING" id="1450535.A0A317WU65"/>
    <dbReference type="GeneID" id="37113730"/>
    <dbReference type="OrthoDB" id="4495335at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="614"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="676" mass="74844" checksum="D56804ED0B35A67C" modified="2018-10-10" version="1">MDSPSSAMSSPTKALNPLSPERINQQIGPNSPSRSSDIFNLQRKTPRGFTDVQAKVAFLNNLSRGNSPAHASQSSAGSAAALQRAVLGREEAESALANVSAQLSEAQSRERRISERLESLLEELQTGKQRQAHERTVFEKEIRKARKEAFRAGSVLVKTQEELKHARNEAKGFKDEAQTERAAKEQAKQEAFERAYAIAGLTEEMEILKEQLRVAEAANRSNKLEARARQIQKNNIGRLSLAEGDLNLLLTPTRRLKRSADNLGNSPQANAVESSPAQDTPSKRQRLSDVTSRKEAEEATMSGAHHDRIDELEEVLERERRLRTMAEDMLEFLKVECRFRRCSCRLEEEDQIDHGYEAQSVETGEKEEEKHSECHGNNHNTLVVPKEPSPSHTPKGEPFGSAAKDQIIRKEVVGDSVVVDGAAGESVKHGTIEDEADGDVDEVVEEVEEAQEVDDDDDEPPEEPLITFSPATGTFHTFPSPVRGSPRKHSEAVLNPHQSPVTRHEDGKNAQLMSGSPTPKYASCRHKIPFDSIMESEAYVLNPTSESHPSPAVADVPWDPVMPVGYRAETPDRNDDSVKVPLRTEDTGSNRFSDVPGTPISREEALAQIRARRERANTMKRSVSASESVLRSGGMGVAPIRNVRRMPGPRTTEARSDGSVRRNRRDMSAPIRLSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUK2</accession>
    <name>A0A317WUK2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Spindle-pole body protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_575002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467713.1">
        <property type="nucleotide sequence ID" value="XM_025615053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUK2"/>
    <dbReference type="STRING" id="1450535.A0A317WUK2"/>
    <dbReference type="GeneID" id="37117196"/>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="8">
        <location>
            <begin position="191"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Pericentrin/AKAP-450 centrosomal targeting" evidence="9">
        <location>
            <begin position="1120"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="340"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="675"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="949"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY87930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1224" mass="141802" checksum="1945EE020768F3D6" modified="2018-10-10" version="1">MAYPYIDTPRTEIDGNATYLTGYRSVGRPNLTALDSVENSFATPSKDDDVLKGFGEGRRRTSGSFKINTPRAGSGPKSTRSALNSRHQLPTAPLAKGEFTPLMRSATKNNFLKNMSTTRGPKTPGYIGRSYLSNGNTPGLPGMEMTDIDEEDATDDQTTPVPQVASSSVQSTPLPGLSRNGGVLNEGNNMTLKEQEKMIDQLDKDNFGLKLKIHFLQEQLEKAGPAYNQAALKENTELKVSKLTMQRDISRYKKNLQQAERDLESYRIQFQELREKARGRPTDDTIQREMDLMREEIEARDNQVRELQEELRDARDSQSQEIEKLRDEIEDLEASVRERDRALEERDEEIEELKDRDGKERDALTELESELQRAKEQMDELQESLDQAKSEAREARDAAGQAVMEKDQAQKDLQELHDEMANKSISTSGLTRQLEEKAMKLEEELHELQQENNTLKKNLEARSRDETRLDEQYQEAQRKMEEAERRLLDDVAQARRERDLARQECDKTSAQLQEALDEVQRKADEKELLQTRHHALTDESGGLQHELARAQAKIKDLQQTVEEEKHHALDSANTVRTHYKEELERLQEEIESLHHEIEDKEGQFALEQDRWESTRRTLQLQKDRAEDQAAGFKRTIEKLEQVEHTLSGKEMKLQEVIDSEKSRHFNSEAVLSRQVKELNDDLTSKREIIDEQRNEVLSLKEELRLVRRSEAALREKMQALEDEVVVLQSSLEEEQEYTKGRSQKGSTEHDGQIQKLITEKQRLRDQLANAHVELHDLRTSAAEIEAERDELQAQLDQVQNQVDDTTRFDKEKVELRKSTLRLEGELRRLKEDKSSLLEAKETLEKQLSTEIERATLEENRLSAEIDQLQDKMHMSSGGRDRELALSKSKIQRLERRIQELETLLHQQPHTDNEHSTANADLSMLRHSLEEARKREKTLLQREADQKSSVRTSKARIAELERELHDTMMNRYETRSPSSSPSNKLHDELRSLRKQLSDAHRTLREVKSKNRDLERAAMREEDQRDLHELLKSSTLEAESLALKVSERDARMNELKAQMRRIRDERSFCARKAEAALKELEALQDRYDHLVEKMGARTENSKTRHEKEILGLGKEIIWLRARMKREEKFRRDLAWSKGLMELGERVRVACNEADLRMISDMGVKPRDRNKLRTPQAKLKTAVSMVKAIVRMQRMSQDWKKTKKLGEGLKRAKNEVLKRRDASHSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUS9</accession>
    <name>A0A317WUS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_535021</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467793.1">
        <property type="nucleotide sequence ID" value="XM_025611678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUS9"/>
    <dbReference type="STRING" id="1450535.A0A317WUS9"/>
    <dbReference type="GeneID" id="37113821"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY88010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="119" mass="14118" checksum="8B584AF22856F4D4" modified="2018-10-10" version="1">MPQDMPPQGGYLPVQYKRNIPARGFRPIYYIVGMHLVMAYGFYKLFYGIREQHELAREKIWGRLHILPLLQAEEDRDQARRYFADKAREKELLGTDSKVYNSSRFVRPTFTYTPTNVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVU9</accession>
    <name>A0A317WVU9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_26902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468874.1">
        <property type="nucleotide sequence ID" value="XM_025606543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVU9"/>
    <dbReference type="STRING" id="1450535.A0A317WVU9"/>
    <dbReference type="GeneID" id="37108686"/>
    <dbReference type="OrthoDB" id="5597581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY90496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="287" mass="32368" checksum="CC8CD233F14EB551" modified="2018-10-10" version="1">MPKDKERSLNPAAAQRKLDKQKSLKKGKAEAQARRNEKLARRNPERIQRQINDLKSLEESGQKLRPREKELLEAFERELRAVQKAREALGDKAPKFGSFESRQGGGQRGRGDAAVLGKRRRDGGGRFGQDSESSDETDEEVRRIPMPRDTPPPTPRQPRKGPDSHQAAGARGPHPLPSRPPVVESKTVYEAKPEIRNLRQEAISKFVPAAVRAKQESIRGQGKLLEPEEMDRLEKAGYNAGPAEAEWKESLGTAGDEEAQRLLEEEERRFNHELRSVQIEEVEDEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWN0</accession>
    <name>A0A317WWN0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AMP binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_48977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468072.1">
        <property type="nucleotide sequence ID" value="XM_025609097.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WWN0"/>
    <dbReference type="GeneID" id="37111240"/>
    <dbReference type="OrthoDB" id="69964at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056881">
        <property type="entry name" value="Mug62_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754:SF32">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22754">
        <property type="entry name" value="DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23024">
        <property type="entry name" value="AMP-dom_DIP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24919">
        <property type="entry name" value="Mug62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="245"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Meiotically up-regulated gene 62 protein-like alpha-beta" evidence="4">
        <location>
            <begin position="785"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="1474"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1590"/>
            <end position="1631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1646"/>
            <end position="1696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1719"/>
            <end position="1773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1609"/>
            <end position="1620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1719"/>
            <end position="1734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY88710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1797" mass="197867" checksum="68C1A2A44846726B" modified="2018-10-10" version="1">MALDFGTPTSGHAPSSSLTGSINPPQAILNVRPPTAESTNQGGPSQPFSNGRDSYNNGSLGYERRISGDTQGSYERESMLLPADRAPSAASYDSLFLPKNQPAPPMQESSRTATLLSQNYAFNPGYHRESYEEPVGGYEMPSGGATRQSTMLDSQQGFFSDFAGQQQDDYRDSYGGGFHRYSQSDTFSPTANMAPPLIPASELHHGPALAHLQPLEPRDIPFAVQDPHDKNTSMSNFDNIPAVLRHRARVHSKQPAYWVLDQKGKEIASITWDKLASRAEKVAQVIRDKSNLYRGDRVALIYRDSELIEFAVALMGCFIAGVVAVPINSLEDYQSLNLVLTSTQAHLALTTENNLKSFQRDITAQKLNWPRGVEWWKTNEFGSYHPKKKDDTPPLVVPDLAYIEFSRAPTGDLRGVVMSHRTIMHQMACLSAIVSTVPVSSSMAKPRGETIISYLDPRQGIGMILGVLMAVYGGHTTVWLEDRAVETPGLYAHLITKYRATIMAADYPGLKIAAYNYQQDPMATRHYKKNSEPNFGSVKLCLIDTLTVDPEFHEILADRWLRPMRNPRAREIVAPMLCLPEHGGMVISVRDWLGGEERMGCPLTHEMDPPEREDSKKEEKKSGKADNNSGFGSSLLGGGGAPAPAPQEQGKTELGEVLLDKEALKSNEIVVLAMGEEARKFAGTMPHAVRVGSFGYPIPDATLAVVDPETNLLCTSNVIGEIWVDSPSLSGGFWALPKHTEAIFHARPYKFEDGNPTPILVEPEFLRTGLLGCVIEGKIFVLGLYEDRLRQKVEWVEHGQEIIEHRYFFVQHMIVSILKNIPKIHDCTAFDVFVNEEHLPIVVLESYAASTAPTTSGGPPRQLDSVLLESLAERCMEVLYQEHHLRVYCVLLTAPNTLPRVTKNGRQEIGNMLCRKEFDAGSLPCVHVKFGVERSVLNLPVGVDPVGGIWSPLALMSRQEMLALQEKQYSGVDYRDVVMDDRTSTPLNNFSTIVDLLQWRVSRQAEELAYCSIDGRGKEGKGITWKKFDLKVSAVAMYLKNKVKVRSGDHLVLMYTHSEEYVYAIHACFCLGVVAIPLAPIDQNRLSEDAPAFLHVINDFHVKAILVNSDVDHVLRQKLVSQHIKQSAQVLRIGVPAIYNTTKPAKQSHGCRDLGFTVKDTWLRTNQAALVWTYWTPDQRRISVHIGHDTIMGMCKVQKETCQMTSSRPVLGSVRSTLGLGFLHTCLMGIYVGAPTYLVSPVDFAQNPMTLFVTLSRYKIKDTYATSQMLDYAMSAMAGKGFQMQELKNLMISAESRPRVDIYQKVRLHFASASLDRTAINIVYSHVLNPMVVTRSYMCIEPVELWLDIRALRRGLICPVDPDTDPTALVLQDSGMVPVNTQIAIVNPETCTLSHVGEYGEIWIQSDACAKSFYGSKQDFDMERFNGRVVDGDPNVAYVRTGDLGFLHTVTRPIGPGGQPVEMQVLFVLGGIGETFEVNGLNHFPMDIEYSVERCHRNIVSGGCAVFQAGGLIVVVVEVTRKAYLASLVPVIVDAVLNEHQVIADIVAFVSHGDFPRSRLGEKQRGKVLASWVTRKLRTIAQFSIRDMEGPENPFAEAPQHRVSRGSKPGSTMGNSTRRSTVVPDSDFMPRSPAPVLVEQSEASIGSYPAMPEPSLNSPTGTMPEGGASAVPHIAEPSRPTSASTNGAPPVPRKELPTTISNPDFGFDFGDFANSASAGSLAGPTAAGPGTEALPYRHDAPPGAPSNGGFPVRSDSYNRRSLADPMEGSTGDWPQEALMYQANLGYDDGHGIHRNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWY5</accession>
    <name>A0A317WWY5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial phosphate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_534657</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468112.1">
        <property type="nucleotide sequence ID" value="XM_025611599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWY5"/>
    <dbReference type="STRING" id="1450535.A0A317WWY5"/>
    <dbReference type="GeneID" id="37113742"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="120"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="218"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY88750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="314" mass="32725" checksum="06C43A9B7A07C483" modified="2018-10-10" version="1">MSANAKVEAPAAPAAPQLSGLQLYSRFAFAGAVCCSVTHGALTPVDVVKTRMQLDPVTYNRGMIGGFKQVIANEGAGALLTGFGPTAAGYFLQGAFKFGGYEFFKQQWINQLGLETASNNRTAVYLASSATAEFFADIALCPLEATRIRLVSQPTFASGLLSGFGKILKNEGVGAFYSGFGPILFKQVPYTMAKFVVFEKAAEAIYGFVDKNTASDGTKTAINLGSGLIAGFAAALVSQPADTMLSKINKTPGAPGEGTVTRLIKIGKELGFKGSYAGIGARLFMVGTLTAGQFAIYGDIKRVLGATGGVEISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WXP8</accession>
    <name>A0A317WXP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase II subunit RPB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_545536</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468469.1">
        <property type="nucleotide sequence ID" value="XM_025613243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WXP8"/>
    <dbReference type="STRING" id="1450535.A0A317WXP8"/>
    <dbReference type="GeneID" id="37115386"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="8">
        <location>
            <begin position="23"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00072506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY89558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="337" mass="37082" checksum="87A549D6AB3CF6A9" modified="2018-10-10" version="1">MDYEMDIEPTGPQVTVREAEPNRVDFKLTSVDLAFANSLRRTMLAEIPTMAIDLVEVEKNTSVLPDEFLAHRLGLIPLNSKNCDQDIEYTRDCECEDHCARCSVTLTLHARCTGDDIMRVYARDLVVNGERANEWVGNPVILDPEGNGPLICKLRRGQELKMTCIAKKGIAKEHSKWAPTAAIGFEYDPHNNLRHVDYWYEEDPAKEWPVSANAAWEHPAPPDQPFDYDAQPNNFYLDVESIGTLDPDMIIQQGITVLQRKLASVISSLSGTEGADRNGVMGGDDEDMMGVRSPDAYEPPEGMDGGFTAYANGGASAWGASAATPYGVTPYGGGYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY63</accession>
    <name>A0A317WY63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_533444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469041.1">
        <property type="nucleotide sequence ID" value="XM_025611332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY63"/>
    <dbReference type="STRING" id="1450535.A0A317WY63"/>
    <dbReference type="GeneID" id="37113475"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="136" mass="14909" checksum="44B58DBB7D4993E3" modified="2018-10-10" version="1" fragment="single">KATIHSSTPGDFTTVEQGSFAFSVPYTTSTFPADLNNDTDIDTHETLLQTNTLGLVNPNGTVCRIVDFAPGKSPLMHRTQSLDYGIGDIAVQRATMHAWRNPSEDKWVRMLFVLQECRPLGEDLGGAVELNPSSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZK0</accession>
    <name>A0A317WZK0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sister chromatid separation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_380406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469542.1">
        <property type="nucleotide sequence ID" value="XM_025607260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZK0"/>
    <dbReference type="STRING" id="1450535.A0A317WZK0"/>
    <dbReference type="GeneID" id="37109403"/>
    <dbReference type="OrthoDB" id="2503928at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HeH/LEM" evidence="9">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="8">
        <location>
            <begin position="352"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="65"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY91814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="81598" checksum="4AD482C611DBA486" modified="2018-10-10" version="1">MADGMEYLAPDFDLNTLTVPRLRSILVSHDVPYPASAKKAQLIGILEAEVLPQARKLLRERERVRRTSEGITDMGSRATSVVSDYDEQRDVPTRDSMPPPPTPSSVSTATGGRRGRSRASVRASTADTEERNATATPSVNSRKSVPRSQSRRYRASDPESHENLLATPVATDTTTPRKSTTRKVRRSEMTPSVNPEPPFSAIKLEPKEESVFTDDNPFQSGSPARWDHKSPRPSSHRSERKSSSRFSLDSPAFSNSLRSRKSATPMDMHDQYGATPSKRSSLEFPSSNFGTPQKDFVPIKYEDEESEFSGGEEFTPDEQLALEREHADLMYSAPSRRPQKQGTASRAAPWVILIILFASFGAWWRKEKIEIGFCGIGKPTWSLAETRVPEWANVIEPQCEPCPPHAFCYPNFEARCEHDFLLKAHPLSLGGLVPLPPTCEPDSEKARRVKAVADKALEALRDRRAKWECGELARDGQEAAGAEISEFDLKQEVGRQRRKGMSDTEFDDLWKGALGEVVGREEVVTKVKQPSSVLTLTSTSVSRLPLTCAFRRNIRLSLVAYRLPLSVLVACASALLYARSRVRARRSDRARVPELVATTLDRLATQAALHARGAAREPYIPIGQLRDDVLRSELRGSRREELWKRVRSVVEGNANVRASVREGRGGDVARVWEWIGGIGSVRGEVESGATAGREGSKVHFSPLPVEQSRDPSIGDSALARSPAESRKWDEGRPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZN3</accession>
    <name>A0A317WZN3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_622642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469574.1">
        <property type="nucleotide sequence ID" value="XM_025617094.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WZN3"/>
    <dbReference type="GeneID" id="37119237"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001272">
        <property type="entry name" value="HEAT repeat protein (DRIM), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="5">
        <location>
            <begin position="872"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="6">
        <location>
            <begin position="1692"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="3">
        <location>
            <begin position="2190"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="7">
        <location>
            <begin position="2247"/>
            <end position="2605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2421"/>
            <end position="2445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2572"/>
            <end position="2616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2428"/>
            <end position="2440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="2577"/>
            <end position="2590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="2591"/>
            <end position="2602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY91846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2616" mass="294328" checksum="D7FD62476DC1A595" modified="2018-10-10" version="1">MVAASSSSRAKPVKRVKGGTETTKSHRFEPFSQRVAKLKIDPIHRVRRPSFGEEADETSSYFRSAFEHWTELNLSDNFVQFARRVNPLCESLAQILYHEEKIMNFLVEYIEKRDKLSIEPLLGLLAQFARDLGVRFEKHFATAVTLVASVAASHPDVEVVEWSFSCLAWIFKFLSRLLVPDLRQLLGIMTPYLGKERQKSFVARFAAESMSFLIRKAGLVYYKNTTPLQRAVSFLLEDLRQTAGEDKNVEMYKDGLMAMFADAIKGVKYGIHSNGGDILSCILDNICTGDDLQSSLGLEVASGVVTNILHNTTVDTFEPILDLVRSYIEKNCTKGEKQHATACSRLIFVCVTTRKGTRVKNWRPVHQTLLLLLQNAAGAPGAYAEAIPQLLTTVAYALQISPMDEMLPFMRSIMDAVSNDELSAHFLAFCATFSEWGPERFHSVVLPYFQKFVNTSWKEHEYELCLSLLRLNHAGCITSEVAKPGYITCPASWKSRVKDTFNKPNHSATEVSLLNAYSKLPSALSLSTEPSLIPELTKTLHGHLIRNLKKKSTDPSATTKFFLGQGFKTYVDLATVAGNIDSSLWDRVSKVAAQYSRLPTFLEATLGYISACKKDIDLQHSTIEDFAEDLISNLSGPSHKLRLLSLRILRELVLASGEDADLISTAIEIEESPLTLQSARVLAMHVRKLALSYPQVVSRRWMARLLPHFCFGLLSKKMAPLWDDAASALKSMSELPEGEKIVSDLAFQWLDERGSGEAAADASDEDSTESYVGGHYTCSNTLKIEDISAKYFENPEQPVTTLSEGFEKDHTFSGVIPASPRTQAMRVLNAVPNIAEKKSRQIIPLFLSWALRDEDDGPGADSKDSNVPYIPWGFHDRLAFLGLLGQFLNPRVLYKAPEVHEALLGLLCHGNSEIQKAALKALFTWKSASITPYQENLLNILDESRFRDELSVFVRIGGDDSLIEEGHRPELVPVLLRLLYGRMISKAGASSGQAGQAGRRKAILRTLSQLPDKEFEIFMQVSFGALGELDLVQDGKINQQAFEQELVTPRRQTGLLKMIETVFDTLQSRVAPYAEKSMQVVLYCLVRACREIEKDQPTPAADSQEGRLLTVLRNIRHTCIRCLELIFSTTQDRDWSPYVGVIFQDVINPRIENFATETAQGVSGLLRLFHVWASAPRSTFYFVQHNDVVLKKVVDCLGVNSARDEVKVFVMDEILVPLVNISTGKELQEQEKMSDIPADEVRFQILSPYIEHTLSHLSRLLKRGPSRPVLISGVQALSLIAPCVESSKETYSLISITTYLLRQPPDRVSPKTKSGLLRTLEHFLPLFDPKEDASLSQEVFEAVSSMFDYFKDNANREILARVFTAFATRDEELVQVASLCEDLNSVSMKRLEVDYERRLQAFREVNENLWDKLSAKQWRPLLYNMLYQVKDEEELAIRGSASFGLKRFMERAVLPTGGDAEDFEPLVTEVLFPALQGGIRQKSELIRSEFLSALGYFVKLNPERPAVQDLHVLLVGDDEEASFFNNVLHIQQHRRLRALRRLASEAAKGNLQASNISTIFIPLNEHFVFDEEADEAAHNLIAEAVNTIGALAEWLDWSQFRAIFRRYRGYMQSKSDMEKNILRLLGKMSDSLTNAMNQHIAIKAAAKDGMDGLETSAPTSTLARSIPSVTKVANELTTNFTPQLTDFIHHKNEAQMSLRLPAAVTTIKLLKLLPETDMSIRLPPVLLDVCSILKSRTQETRDTARKTLNDIAILLGPSYFGYILKELRTTLTKGYQLHVLSFTVHSMLVFTTDEFKQGDLDYCLTDLSSIVMDDTFGTVGQEKEAEEYVSKMKEVKSSKSFDSMELLAKNSTVRNLAGLVRPLQSLLREKLNSNIVRKVDELLRRIGVGLLRNPGVESRDILMFCYEVIKETYNAPVKVQTQVAKTAQEENLLINLHGSKRGEKRGATSSYIHKLTRFSLDVLRAILSKHSSLLTPANLTGFVPIIGDALVQAHEEVKISALRLLSTIIKLPIPEIDSNSHVYFTEAVKVIKEAPSTNTEAAQASLKLVSAMLRERKSTKLRDGHLAYLLQRITSDIEEPDRQGVTFNFIRAVMARKFVVPEVYELMDHIATMMVTNQARSARDLARGTYIHFLIEYPQAKNRWTKQLSFLAKNLEYKHQDGRQSVMEAIHMLLAKTGDELAQDIVSTFFLPVVIVMANDDAPECREMAGTLLGELYTRADREQMKTMLTPLRSWVEQTDNLLLTSTGLQAMRIYFEVEGTEKDKEARFVVDMLPAIMQPVLKAEETENWQALYFSLQLFSKLCKSVPNIALAKERAKIWAAIRECLFYPHAWVKTCAANLVGTWLADLAKHNAAVGYGSLPLAGSTGLGLDKDAMLQLIRASLRSLRTPAVSEELAMQSVRNIIFLGRCCAQNGLEFPKAGDKDAESDASDSEDEANGEETERPVDAPKSAIRYIFEQTSSILRRELLTTRAESLIPKTASIGLFASLCRHLEVDQIRESLSVILLPLLHMTDPNIPPPRSSDEVFRESYKGLVSNCHEVLDIIQKKLGPTEYISQMAKVQDAIKERREGRRVKRRIEAVTEPERYEKDKRRRNDRKRDKRKERGAEHRSRRRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2W8</accession>
    <name>A0A317X2W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_583881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469700.1">
        <property type="nucleotide sequence ID" value="XM_025615589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2W8"/>
    <dbReference type="STRING" id="1450535.A0A317X2W8"/>
    <dbReference type="GeneID" id="37117732"/>
    <dbReference type="OrthoDB" id="5396420at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="442" mass="49745" checksum="D0C1CC5FEC8CCB1B" modified="2018-10-10" version="1">MRVFSSKQLSPAGASFSEYRDSINIPVGANGSIALDITHPTYAPIRARDNVIIRLPPGPIFSFSPEGLPTYSPPRHRGPPSKEYVPRSLATITSSTIVTINYRLGNLPTNSDNPTDLAFHDYKYPTPVHDTLAGLDWILETLQPSRLSVIGTHIGGSLALMLSLTEAKSIHAVAALEPICDWTSLDEHCIQSPPTDEKAALTSWRNKKHPRGRVAPWDLPPLLAARKAYFSTPERYFDAFASPILFLRSAGKDTPRSFPEYYTGPEYPVPVLKAGNASEGEDLLDSLDVYRHEEQESTHDSYSKDSETKREPPRRRKAISRWPPFGLDYGTSGPTWHHPGQGIKRLEMELPWVRISTRVDDSLSKSGLLMAAPGARKWKRVHTDSVLYQQAHEMVDVMQRACFWGREKGYGQKRVTLTQFLEHDWTLSHHRAADWLREVMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X324</accession>
    <name>A0A317X324_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PQ loop repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_462653</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469116.1">
        <property type="nucleotide sequence ID" value="XM_025607984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X324"/>
    <dbReference type="GeneID" id="37110127"/>
    <dbReference type="OrthoDB" id="407617at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF37">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY91388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="284" mass="31594" checksum="69DD8FFBDA0BA940" modified="2018-10-10" version="1">MAGDGNVTVASNVLGTIGTVLWCIQLIPQIWYNWRRKKTDGFPPLMMLLWASCAVPMGAYMILQEVNIPLQIQPQIFGFFSLVSWGQIIYYNHDYSCLKTTLLVVCTAVLFGGIETLLILTLRIPYNKGVTWPDLVVGVVAAILLASGLVPPYFELWKRDGRVIGFNWVFLSIDTLGGLFSLFALAAQGSFDILGGIMYILVIVLEGGIYASHIIWRIRYRAVRKEAKSLGKSIDEMLEERNGFPVTHDVEKVIMTPHPQGAGSHERFEGKVNATDLEGEIRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3V7</accession>
    <name>A0A317X3V7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_532969</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470007.1">
        <property type="nucleotide sequence ID" value="XM_025611237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3V7"/>
    <dbReference type="STRING" id="1450535.A0A317X3V7"/>
    <dbReference type="GeneID" id="37113380"/>
    <dbReference type="OrthoDB" id="446635at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="163"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="265"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="383"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY93246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="458" mass="50024" checksum="01F495A7593B5336" modified="2018-10-10" version="1">MPPPLSLGLNLSNKSKPKPGLNPLGGGGQKRKKTIFDDSDSDTEAPSNATNANQASNEIEISTIGGLEESSSFPPSRKNNQDDGEGGQRPPKRKLLAPGAAAGASKPSNFKPLSKKSIFADDDEEDEKKDTDEGKDTTVYGLNTSAAEKKKEYTNLAALHSSRKHAAEAETLDPSIYSYDAVYDSLHAKPDAKKKAAAEEKAAGSEVPKYMTQLLRSAEVRKRDQMRARDRLLAKEREAEGDEFADKEKFVTAAYKAQQEELRRVQAEEEAREKEEEERRRKNGGRGWHEAVVKAAEEAAKRVKDGMEEGAAEEEEKKEKSEAQVAAEMNAKGAQIAVNDEGQVVDKRQLLSAGLNVAPKPKAAPKDTAAAAAAARAAVQARFGAQRQAERGGQRARQTEMIASQLEEQARQEEEAEAARQKEIAERSRSRKTEGEVSSAKERYLARKREREAAAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4G0</accession>
    <name>A0A317X4G0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_363830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469996.1">
        <property type="nucleotide sequence ID" value="XM_025607184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4G0"/>
    <dbReference type="GeneID" id="37109327"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="115" mass="12770" checksum="9F71C6AEAE71CC97" modified="2018-10-10" version="1">MAGLLQRHGRIRSRCPVSPRPSDVTLIPVTPATGVQYGGSSWSWWYCTDTESVCFPFFYYFFFYFCLSSAPSSSHSLSPLSSRNRPLSTITFSCLPLSLSLLPLSLSLSPPPQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4K9</accession>
    <name>A0A317X4K9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_583371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469892.1">
        <property type="nucleotide sequence ID" value="XM_025615554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4K9"/>
    <dbReference type="GeneID" id="37117697"/>
    <dbReference type="OrthoDB" id="5279008at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="55110" checksum="A7DF3E6D8B40684D" modified="2018-10-10" version="1">MVSTNITSLPVEIPNRICQDIDILDLFALRLSSFSLALKTQHHFAFRAFEKILLVLTSDGLQVLKHIASHEVFRKHVKNVTGDQGLWIVTTHFLGNHEWSAEDMDHLQQGYATHATDSEKRNFREETVSLPERSREERHALYQDAVADHLKVRDGQVIQAALEHCLPSFTNLHIAAHLNVGRPPDAPGRFKGIRGLRKQLRFDPLHVVGGESKHSHTTNAKILSILLAAIASTKTKIKYLDTSTGDLVCPVAHNGLHFTSAEKVLLLPIIQTLVGLGLYCSSSHKDLLAQEALEPNSDGKSKDTLEFLAKAAPNLKTLQVRFDNRHKAEDDREPLVDQHFVWMSQKFHFSRLSRLHLFNIRTTTSSLMQLLRSAMPTLRIFVFGSITLRHYGNFPSPMERDDEFFDNGVRVWREVLNLVRDQGSLRQLGVDKLMYQNQRIDIIAHYAERTAHVSIQDWIDELKLFAMDEILHEPRPADIQAPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4N7</accession>
    <name>A0A317X4N7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone h1.3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_582919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470297.1">
        <property type="nucleotide sequence ID" value="XM_025615513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4N7"/>
    <dbReference type="STRING" id="1450535.A0A317X4N7"/>
    <dbReference type="GeneID" id="37117656"/>
    <dbReference type="OrthoDB" id="5403747at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="25340" checksum="56081FBE68320DD7" modified="2018-10-10" version="1">MSTPKSNKPEGLMGLSLAEARMILLGVLSSDDAGKVDFDKMALLGGYKNAPSASTLYRNAKRKLLSENAGNQDGTTSTPSKGPAATPKKTPAKRKKGKADEEDGEVATGASPAPPKPKRQKATGTPKTPRAGNKAVKTEDENSTLEPSTPIQMRAAVQKEAKSEVKAVKKEDSSDTDAYYDDLIKKEDDRSDTEELMDASQLSREFTAMEEGQADSKADSKSVSKDGSKDGPKNDSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4S1</accession>
    <name>A0A317X4S1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_486800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470334.1">
        <property type="nucleotide sequence ID" value="XM_025609019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4S1"/>
    <dbReference type="STRING" id="1450535.A0A317X4S1"/>
    <dbReference type="GeneID" id="37111162"/>
    <dbReference type="OrthoDB" id="407010at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF24">
        <property type="entry name" value="CAROTENOID ISOMEROOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="61299" checksum="C77969A937159B3E" modified="2018-10-10" version="1">MSTIQEIHQGDHFNNWPNVKGFDANYEEKTPVELDVEGQIPAYATGVLYRTGPGKYKVDTVNGDTFRASHWFDGFSEAHRFQLVAPDTTHPSMRVFYNSRFSTDSLIEEVRQTGDLIKISFGQKRDPCKTVYQKVQSDFEPAKPPTPTSANVGVTLSINMPGLDASSTSRASDRWDTSTGIQTLHAKTDYNVFKQLDPETLEPISLATQQDLHPDLDGPETASHARSDPNTGDVFNYNLAAKPSPTYRVFRISASTGETTILATFPAKPAYLHSLFLTEEYVILCVWNAHISLSDLGNMSFLDSIQPFDPSEPAIWYAVDRKTDKGLIATYQSPPFFCFHTINSWQETTPDNKTDIIAELVMFPNLDILHKLYYENALSDSPSAKALCEGRTSASSSTIARFRLPAIPSTPNSSPLPTILESSLCKSLSPELPTMNPNYVTRKHRYTYSVADRGESTLFDSIMKLDSETHKTLIWAHHAQSPGEPIFVANPDGESEDDGVLLSVVLNGMTGKSYLLCLDARNLVELGRASVNGPVAFGFHGQHVPVRGIPTGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5I9</accession>
    <name>A0A317X5I9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_617264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469538.1">
        <property type="nucleotide sequence ID" value="XM_025616827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5I9"/>
    <dbReference type="GeneID" id="37118970"/>
    <dbReference type="OrthoDB" id="4425826at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="93" mass="10966" checksum="8AE772830F6DC7B3" modified="2018-10-10" version="1" fragment="single">IYLNIFKINSQVFVPFILVIISRVCLLFNISKFKSKYTKQETLFSCNKALPIFLDITRKHGLEKTLIFKKLLNAIFYLTPPLTDTDKNKYYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5K7</accession>
    <name>A0A317X5K7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_572452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470655.1">
        <property type="nucleotide sequence ID" value="XM_025614924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5K7"/>
    <dbReference type="STRING" id="1450535.A0A317X5K7"/>
    <dbReference type="GeneID" id="37117067"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048269">
        <property type="entry name" value="RNase_U2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037430">
        <property type="entry name" value="RNase_U2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016346183" description="ribonuclease T1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="128" mass="14309" checksum="7EDCBA2550DABAC9" modified="2018-10-10" version="1">MLYSKLILLTPLLAHLTLASPNTCAYTCGTSCYTVSAISAAQSEGWKLWEEWRTVGKDKYPHTYHDYEGFDFPVEGPYLEFPILRNGEVFTGGEPGADRVIFNRRDEFAGVITHTGAEGDDFVGCDQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5W7</accession>
    <name>A0A317X5W7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470476.1">
        <property type="nucleotide sequence ID" value="XM_025611163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5W7"/>
    <dbReference type="STRING" id="1450535.A0A317X5W7"/>
    <dbReference type="GeneID" id="37113306"/>
    <dbReference type="OrthoDB" id="3993201at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="1">
        <location>
            <begin position="49"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="251" mass="27275" checksum="96F11185B119EDB6" modified="2018-10-10" version="1">MAATRSSSLRALRVLSQQHSTTPTIRRGLHITGAHSAQPANVSDRASLYASRTLTDLKNECSKRSLRSSGTQAELVERLSNHDFLQSRAFSIAMRRINGSSSAGKSHDRQFNTSRSSKAVNDSSTVDFAYMPSMAEIDGAAARADPQIPILSEIYTHYDATQTQSAPMRPQVYTVSGGAADVSASPMTEVVDNHSVDIDPFSLTETVGKSRFGQELNRQQNGSSEPGVVRELWSGFLEDLLGPKQQHAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6M4</accession>
    <name>A0A317X6M4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_325254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470980.1">
        <property type="nucleotide sequence ID" value="XM_025606933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6M4"/>
    <dbReference type="STRING" id="1450535.A0A317X6M4"/>
    <dbReference type="GeneID" id="37109076"/>
    <dbReference type="OrthoDB" id="5131368at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151">
        <property type="entry name" value="BLR2777 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36151:SF3">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="1">
        <location>
            <begin position="54"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="301" mass="34155" checksum="3F943D53C05FC245" modified="2018-10-10" version="1">MVFGHAMLAVLVALVVITFRLLSHGKHLSVSRSSSSEENLGKLAPNDTQHIQKVLREGIILAGGAAAILLQLAMPGIGKAIDIHSNFSYRPLDRLRTTMTFIYCMAFGTPQEKRIVVDMVHRAHAPVKGAGYSADDVRLQLWVAASLYAIDISLYEDTFGWMDEAAAEAVYREYAVFATSLRVPVEMWPVNRKAFWAYWDQQIEQVEVTPEAKGVAHDMLYNKRLPLHMKILMPSVRLITAELLPQRVGEAYGLKRTRLGRVALGVMKATYSLIPTYIRTYPMAYYLKDMRRRIERRSDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7Q5</accession>
    <name>A0A317X7Q5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">LYR motif-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_347015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in efficient integration of the N-module into mitochondrial respiratory chain complex I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470348.1">
        <property type="nucleotide sequence ID" value="XM_025607079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7Q5"/>
    <dbReference type="STRING" id="1450535.A0A317X7Q5"/>
    <dbReference type="GeneID" id="37109222"/>
    <dbReference type="OrthoDB" id="74240at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd20262">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045293">
        <property type="entry name" value="Complex1_LYR_LYRM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13675:SF0">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="7">
        <location>
            <begin position="33"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00026235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="102" mass="12105" checksum="6F5B27613B969873" modified="2018-10-10" version="1">MRSSLNLLASVSRSRPSKLKKPTISLDHFIQRQRVISLWREITRALNKIPSSSTRDELHSYARREFERNRNITDLQHIRYLISTGKSEFEMMKRYVDEQVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8H3</accession>
    <name>A0A317X8H3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_564319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469969.1">
        <property type="nucleotide sequence ID" value="XM_025614410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8H3"/>
    <dbReference type="STRING" id="1450535.A0A317X8H3"/>
    <dbReference type="GeneID" id="37116553"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="35"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="537" mass="57134" checksum="B1E11ACC7A81FB4C" modified="2018-10-10" version="1">MADFLQDSKKSAVESGASFSEEEKRHIVGVKWFIFVVSALTAIFVYALDNTIVANIAPTIVNHFNAVEDLPWLSVGFMIGGMAMMLPFGKIYAMFDAKWVYIVSMVVFMAASALCGAAPTMNAEIVGRVFAGAGGNGMYFGLLALLSTNTTSQERPKYLGLTGLVWGLGTVLGPVVGGGFELYTWRWAFYINLLLGAILLPAYLFVIPSNDPLPGVSVWQKLASFDWVGAVLSVGAFTTLVMGINFGGTLYAWNSGQIIALFVVSATLWVVFGLQQAFNILTSVPNRMFPMHLLRQKEPVLLFISCAAVGAVACVSVYYIPIYFQFTQGDSAIKSAVRLLPFICLLITTIPASGAAMSWIGYYKPWYVGGSIIALIPAILMATIVNTHTSVGVIYGLEVVLGLGAGAYAQASFAVIQAVVPSAEASNGLTLMILAQLSGMTLGLSISGAIFVNEAQTHLYALLPDLPRAYVGQIVSGTSSHVLASLSDTLRVQALDIIVSAWHNTFICVFVGAAVSLVCAVFMSHKRANITATAGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8L9</accession>
    <name>A0A317X8L9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_581934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471302.1">
        <property type="nucleotide sequence ID" value="XM_025615442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8L9"/>
    <dbReference type="STRING" id="1450535.A0A317X8L9"/>
    <dbReference type="GeneID" id="37117585"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF28">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="145" mass="15328" checksum="2ECDDD0403128C8D" modified="2018-10-10" version="1">MPNLPNLTAANSPAYYQERSFSHPPRPTHFQQAHTTQEKQRHPICIVIPSSANDVATAVKSLAELSNSTFAIRSGGHSSAAGAANTDNGVTINVQQLKTIQLTRNDTVISVGGGASCSDLFAALKGGQNSFGVVTRFDMAIFAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8M7</accession>
    <name>A0A317X8M7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_456349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471717.1">
        <property type="nucleotide sequence ID" value="XM_025607696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8M7"/>
    <dbReference type="GeneID" id="37109839"/>
    <dbReference type="OrthoDB" id="3063476at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF1">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="145" mass="15800" checksum="43BB3A2DCC95C697" modified="2018-10-10" version="1">MGGARNISHGRGGAGNIFSGTKESRTTPKDLVTPTIKQDVFTTGRGGSGNMMHNDPEHPELAREMQDVESPPLRMEEAPHFMGRGGAANAYIPTPEEEKRVREQEEEQLRRVRTQSKDRRKDIETGSVSGAAAAEGDGEERNPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8P7</accession>
    <name>A0A317X8P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_316848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470763.1">
        <property type="nucleotide sequence ID" value="XM_025606869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8P7"/>
    <dbReference type="STRING" id="1450535.A0A317X8P7"/>
    <dbReference type="GeneID" id="37109012"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="297" mass="33751" checksum="9D3F010E079039AC" modified="2018-10-10" version="1">MLRKPNILCCGGLQLLNSPCPSSPWSRALPSQSHPAARRYATASDSSVKDLSWPANPIFTPYELFKQDRTAPYSKTRYYEMVKVYHPDRPCTGHPSCRDITPEVRLQRYHLLVAAHEILSDPSRRAAYDRHGTGWNLHPSVDGTPTPSWAKTGSSDYGPIYANATWEDWERWHNRHQGKQETLVDHRTFATFVILLTLMGGAVQASWISKLSTGYEDKLLEINEESSRLLKGRRESTQKQMGSSDARVQHFLMRRDPSGCGLKEEEQPIYKEVLRFQKSSDSSAEVEDTGSETEPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8Q3</accession>
    <name>A0A317X8Q3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_531601</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471426.1">
        <property type="nucleotide sequence ID" value="XM_025610937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8Q3"/>
    <dbReference type="STRING" id="1450535.A0A317X8Q3"/>
    <dbReference type="GeneID" id="37113080"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="56" mass="6402" checksum="33328B511B0E15A3" modified="2018-10-10" version="1">MSQPHRKRRKIALACTPCRARKIRCDGVEPTCGPCKRRETSCSYPGENARKIQDNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9I0</accession>
    <name>A0A317X9I0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD+ kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_486202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471053.1">
        <property type="nucleotide sequence ID" value="XM_025608999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9I0"/>
    <dbReference type="STRING" id="1450535.A0A317X9I0"/>
    <dbReference type="GeneID" id="37111142"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000029">
        <property type="entry name" value="NAD+ kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="500" mass="55823" checksum="83B9C25D1F6035FA" modified="2018-10-10" version="1">MPKLTWPKSRGGTEDSDTHNQLEVVLYPECNHRRKSSLVMADDPVTRPDLSHPDQTTACFVHSLIAGEWGDPKHKIKELEGVLRGSKDEDEEEATGDEESDSHASTIEKAMVQSRHLTKKQLSDMAWNVRKLSKKLDSIKLRLTVKTVFLVTKAGDQSVIGSTREVARWLLSKDRATLYNVYVEKRLETDPEFGAAQILREEPSAKSRLKYWDHELAVERAHLFDFVVTLGGDGTVLFTSWLFQHVVPPVLSFSLGSLGFLTKFDFNDYQKTLTAAFRDGVSVNLRLRFECTIMRSKPLPEGSSCAGGKRDLVEELIGEECIDTLTHRPDKVLQILNDVVLDRGPNPTMSSIELFGDDEHFTTLLADGVCIATPTGSTAYNLAAGGSLSHPDNPVILVTAICAHTLSFRPIILPDTIVLRMGVPYDARTSSWASFDGRERIELHPGDYVTVSASRYPFANVLPRGRRGDDWVHSISKTLNWNSRQRPKSLEPVDEEKGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9U5</accession>
    <name>A0A317X9U5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_532608</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470439.1">
        <property type="nucleotide sequence ID" value="XM_025611155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9U5"/>
    <dbReference type="STRING" id="1450535.A0A317X9U5"/>
    <dbReference type="GeneID" id="37113298"/>
    <dbReference type="OrthoDB" id="1053771at2759"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071265">
        <property type="term" value="P:L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000002">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="18">
        <location>
            <begin position="4"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="17">
        <location>
            <begin position="443"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="712"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="448"/>
            <end position="450"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="448"/>
            <end position="450"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="532"/>
            <end position="533"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="578"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="616"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="659"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="661"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="683"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="744"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY93678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="774" mass="86888" checksum="50F1A5C3EB3FECEC" modified="2018-10-10" version="1">MVQSSVLGFPRMGKLRDLKKATEAYWGDKISRDELLAEGKRLRLEHWKIQKDAGVDVIPSNDFAFYDQVLDHIQMFGVVPERYSKYNLHPVDEYFAMGRGLQKPAKDGQAAIDVPSLEMVKWFDSNYHYVKPTLQDNQTFKLAAEPKPVVQYLEAKEAGVITRPVILGPVSFLTLAKADRGQSVDPITKIDELLPVYVELLTKLKEAGVEDVQIDEPVLVFDLPAKSKAAFKPAYEKLGALGAQAPRLLLATYFGDIVHNIDVLPALQSLYGIHIDLVRNPEQLDAVVAALGRKQVLSAGVVDGRNIWKTNFKAAIEKVELAIQKLGKERVIVATSSSLLHVPHTLESEKNLDAEVRDWFSFAVQKLSEVVVIAKAVTEGPAAVREQLEANAKSVQARASSARTNDPKVKERQAAVTEEQHNRKSPFATRIAEQSKSINLPLFPTTTIGSFPQTKEIRIQRNKFTKGEITAAEYEKFIEKEIEEVVKIQEELDLDVLVHGEPERNDMVQYFGERLTGYVFTTHAWVQSYGSRCVRPPIIVGDISRPAPMTVKESKYAVSISKKPMKGMLTGPITCLRWSFPRDDVHQSVQAQQLALALRDEVVDLETAGVKVIQVDEPALREGLPLRAGKEREEYLKWAVLAFRLATSGVTDGTQIHSHFCYSEFQDFFHAIAALDADVLSIENSKSDAKLLRVFVEEAYPRHIGPGVYDIHSPRVPSEQEIKDRVEEMLPYLKPEQLWINPDCGLKTRQWPETKAALTNMVNAAKFFRQKHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA54</accession>
    <name>A0A317XA54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sulfate transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_581444</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471862.1">
        <property type="nucleotide sequence ID" value="XM_025615408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA54"/>
    <dbReference type="STRING" id="1450535.A0A317XA54"/>
    <dbReference type="GeneID" id="37117551"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034490">
        <property type="term" value="P:basic amino acid transmembrane import into vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000141">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000012">
        <property type="entry name" value="Sulfate transporter family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052706">
        <property type="entry name" value="Membrane-Transporter-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310:SF4">
        <property type="entry name" value="AFR304WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43310">
        <property type="entry name" value="SULFATE TRANSPORTER YBAR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="664"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="11">
        <location>
            <begin position="735"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="952"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY95101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1066" mass="116595" checksum="9726FFC082C57E7C" modified="2018-10-10" version="1">MGVLRSRDSGDFRISGLSPHRSPLEDDVDPEGTEIPVEHANNGSPPRSSGLESMVSGGTSFRTPSRSFFHRSFHSPADPAHYSSHGLREQTAELASFALSHESSALPPSLDIFQPSQSPNRPSSPALSFAAPRRTNLEPGPSSIVTTGSSVLTQLIRSPDGPEIDQDHPDRTASWDELSESEVSEDHPLIAAAGGAPTTEQASLLPKTTHAGPFQGYGAIGDIENQGRAGKGEMDAVPRALHQLKMGVRVLANPKSWDGQTVWREGIVYPLSLLPSVFLGLLLNILDALSYGMILFPLSEPVFSDLGSDGISMFYVSTIISQLVFSCGGSIFKGGIGSEMIEVVPFFHQMAFTILNRVGQDNPQAVLATTILSFSVSSILTGLVFFLMGTCKLGALIGFFPRHILIGCIGGVGFFLLLTGVEVSARLPGSFEFTLKTLEKLMQLDSIFLWTIPLLLAIGLLVLKRFLRSNFLVGGYFIVVAVVFYIVKLSAGVSMSSLRGRGWVFDAPSSSNPWYHFYTLYDFSAVDWSAFLDTIPAMFALTFFGVLHVPINVPALGISTGEDNLNVDRELIAHGVTNALSGFAGSIQNYLVYTNSLLFIDSGGNSRLAGVMLAAATAGILVVGPVIVGFIPVMVVGALIFLLGIELMQEALVDTWGKLHRHEYLTVVIIVATMGAWDFVVGIFVGIILACLSFVVQTSRKSAIRATFSGKITGSTVRRPPIQQRFLKEAGHQTLIIKLGGYLFFGTIVSVENTMRGLIEEEAFNQRPIRFLILDFSRVYGIDFSAAEAFTRINRILRKRNVQMTISGLDVEGDVGRSLQNVGLFESANDVEIFEDLNSALEFCENDYLKVFYSHREALLNGKNKSTAFLEVPAAQGQSHLGDAVVSSPRQRYLQQAARTTLHENEIAVVQPAAWSAMRQPLPLLLQTFQGLTSRNEDFWFKACTYFVRESYAAGTVLFHEGDIPKGFYLLESGMLRAEYELPQGRYFEIIVAGRPCGELPFFSDTRRTATVKAEQDCVSWCLTAEKWQTLREREPEIARELLTVSLKLTTERMDSITSYVLTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB17</accession>
    <name>A0A317XB17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLAC8-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470899.1">
        <property type="nucleotide sequence ID" value="XM_025611054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB17"/>
    <dbReference type="STRING" id="1450535.A0A317XB17"/>
    <dbReference type="GeneID" id="37113197"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="36744" checksum="711FAB80493BBF53" modified="2018-10-10" version="1">MSQQLHLNTSNLGGNPRYSYLETPLEMHAPGNRLRSEAQPPAATSTLQPAEIQPVMEHFQPPLNEKAQQYQQDMAVSGYSCGPNLEQHPANYAPYADEIQQVQHNPKVAEYPYAEPPRSPGPLPVKVNPELSQPLPSTQPMAVVPDANPLHSPQLPQFPPPVASGAPATPAAIDLMAYHQPGQITHPDLEIRGGSWRTHMCGCSDIGVCCLGLTCPCILYGRTQYRLSRKLRSEDPTNMLGYDVCNHSCTAMALCCGCHWIFATLQHRRTRKVYGIEGDIISDCVRATCCTCCTLIQDEAEIKKREEERGIFAGAAMVSPYMPPVQMSYGPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB32</accession>
    <name>A0A317XB32_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall proline rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_284454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471548.1">
        <property type="nucleotide sequence ID" value="XM_025606650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB32"/>
    <dbReference type="GeneID" id="37108793"/>
    <dbReference type="OrthoDB" id="5406427at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="634"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="782"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="96702" checksum="B4BE33156968AC1C" modified="2018-10-10" version="1">MASISLPPQPQATPAFSPYLSATDRSPSGHTRRNLRMSAPLPNPPFVFPARDPGDATPQSSETRTRTALPLPAFSFNPGAQHSAQPSMPTLSPNRPAGHRRRCSELVGGERPIIPPGTIEATRSNDETPAPPPTKLPAPGPGFGAGGRRHAHRRSAAISSVDLTAISNALDLKPSIGSAPCFPADTMREHHASDEPPRPVSQSAAVLTRQSPPVSPRIVIEEDHSEPETPSNVTTPERHSTETLTNDSGFVATSQPDASARNSGYTCFSPSADKAPPMAEKSKPRPRTADASFMLDPSRTSKPDDDSPTKRPLSAAGHSRNRKSLSSGILDHFAGSSRRSSSSSSGSESSSGTSVSEATDSPESPSGKKRSKAKKRQKKVRSWAGAFLTRGKGKRHSKKDRTEAKGAIPPPVLTRTNSDLGSGLDVDFDDDNIVVLRTPTNPGTPESSRLPAEGTPPSLETSWKPRSFYEQSVQNDVLSPVIDLDAALGPFNTPEMRSGRVAESGFSAATKRMYSGGRRGEFIGPEMRYHRRAESAPEMPPFDRSCLGNNRFVTSSTLENPDVLYEEEEDAFLAATGGSHPGPIERPPPQVTTSSTADADSQSEDSKDSSETLTHQSLAREISEDGLLHAGLGIQKDESNDAPDDTTPCLGQEKRNSAEQQTSLAQFHNATNPFSAPMQNPAEVVKQDEWQHRPSSPDYSPGFMPADHGAGTSLEMTSNIPPLSLQGNNSLPNSSFPSPDFTLSSDVPRSITTSSTNDRNFSNPSYNPSVDLPQGSVEDVPSLTSSASTTTNTLGRISGTFFSRPRLSTDRSASFSAAVRRRTSQANSSKRSSLASLSKLMVGPHAERSKLSYEEKPPEDEPERAKKKGLRISRLMHFWRTKDKDKSYHEPGVRDQRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB73</accession>
    <name>A0A317XB73_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_213822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471683.1">
        <property type="nucleotide sequence ID" value="XM_025606174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB73"/>
    <dbReference type="GeneID" id="37108317"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17132" checksum="05B97F76CA33631D" modified="2018-10-10" version="1">MIGRPSSRYGPFRPEQKVPCSRSKHHGSPQRPICREQLNRTYRFPFPYTFGNHQIVRMMGLGLSVALCSASKSNGPSGLGRSPGCRMSPGGKSVNVIGKGLTSFGPVIGRGGQRAIWNPSAEATAIHSRAVRPAVAANGQVSSSHRSKGPVPTVQVIGSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBS9</accession>
    <name>A0A317XBS9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">A/B/D/E cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_456630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin AB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471828.1">
        <property type="nucleotide sequence ID" value="XM_025607709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBS9"/>
    <dbReference type="STRING" id="1450535.A0A317XBS9"/>
    <dbReference type="GeneID" id="37109852"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000005">
        <property type="entry name" value="G2/mitotic-specific cyclin B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="250"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="343"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="347"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="482" mass="54184" checksum="9C9F5A337FBF3DA0" modified="2018-10-10" version="1">MNENDENGPSTRLTRAKAAALSAGDAPAPAAKKPLQTKKAATTTTTTTAGPQRRRAALGDVSNVSKTENGETKESKKPAATKVGLTSKATLQAGGVQKLTRNNSSRSALGPKDSNPKKPATEVKRPGSGSGTKRTSSEKAIQEKALEEERPRKKVDIEKKVTEKKTVTEKVSSSKEDVNVPVDPKVLQKPADDYVDDLDAEDLDDPLMAAEYVVDIFEYLKDLELETLPNAEYIEHQPDLEWKMRGILVDWLIEVHTRFRLLPETLFLAVNIIDRFLSAEVVALDRLQLVGVAAMFIASKYEEVLSPHVANFSHVADETFTDREILDAERHILATLEYNMSYPNPMNFLRRISKADNYDIQTRTLGKYLMEISLLDHRFMGFRQSHVAAAAMYLARLILDRGVWDATLAHYAGYEEEEIIPVFHLMIDYLHRPVCHEAFFKKYASKKFLKASILTRQWAKKYHHLYISSSLSEPYAFIKDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCG7</accession>
    <name>A0A317XCG7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AhpC-TSA-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_619395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472994.1">
        <property type="nucleotide sequence ID" value="XM_025616858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCG7"/>
    <dbReference type="STRING" id="1450535.A0A317XCG7"/>
    <dbReference type="GeneID" id="37119001"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050553">
        <property type="entry name" value="Thioredoxin_ResA/DsbE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42852">
        <property type="entry name" value="THIOL:DISULFIDE INTERCHANGE PROTEIN DSBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42852:SF17">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN HI_1115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="55"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="206" mass="22799" checksum="F7786A33F336343E" modified="2018-10-10" version="1">MLVSTNLRWDSPRQSRAILAEPPTRYGLDDSDKPAIKSETQVAVSLLGTAIDDIGHVGNQLPSFRLKDAVGVEQNSADLLGQDALLITFFRGEWCPFCNIAVAGLQKYHTVLKSKGGNLVAITPELPNNTWTMTQKHELEFPVLTDHDNEFARQLGIERNGDDSVEVPIPATLLVDKDGIVRNLFLEPDYYKRVGSMVVLGWVEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCN8</accession>
    <name>A0A317XCN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_139935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472652.1">
        <property type="nucleotide sequence ID" value="XM_025605719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCN8"/>
    <dbReference type="STRING" id="1450535.A0A317XCN8"/>
    <dbReference type="GeneID" id="37107862"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="137" mass="15216" checksum="7B75E117D017A8CF" modified="2018-10-10" version="1">MPIRPLDEWAATRTQHLPLSALKGAVVGIDASHYISQHLLQPSTREPLLIALGGFPFALKSNIEKELQVYKDLGVGCIFVFNGLDFGKKDQRPHVQQESVRAFEQAWDLYDQQQADQVVDAFSSAGTTLVLVLEARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD48</accession>
    <name>A0A317XD48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_619937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472278.1">
        <property type="nucleotide sequence ID" value="XM_025616901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD48"/>
    <dbReference type="STRING" id="1450535.A0A317XD48"/>
    <dbReference type="GeneID" id="37119044"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051114">
        <property type="entry name" value="Mito_RNA_Proc_CCM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934:SF6">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN PET309, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="PPR" evidence="1">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1126"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1132"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1200"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1213"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1266" mass="143741" checksum="D66E9133AA6AAEBA" modified="2018-10-10" version="1">MLERAAGCLENAGRRFFRDPNGAIRGRSSIYSTIGQYATTGAELLVLLQPPQRSASNNLNASSTTGRAATDPRPPVLEFLYPPRTQEFIASCLLHSPKRLVSRRRKKAVPGLPRNYSSEATSLDRGTETESQFFDDSNEVITDEDRVLARDELQALLDEDEFQDYDKTWGLYSKAGHPLDLNSALLAGFSGSDREVDCRRAKRLLSSIPLEARSPEDFMHLAKSYLTTGNFLDANELCREAISYGRGLSCWAFSFAHVINNKQWDWVLDIWDSRPSCEENDLWRSVASWLIASSIQKPLVALADYIEVQSDDSPVRNVARFLLDNVFSSPEFAEATPTETLLILLQKFNNLDLVSARNYLNLIKILQASEHRFTFVRSIVIYRNFRWQMEEEIPPAKLLGQLLRRLASFEITTGISYFLDELTRFHDKPSVDAYKQALIAFSRAGDVTNVHHVFERLVSDHGNPRSRRLLTPLLYVYARIGDVQETARQFRRISEEFGLQPDTVCWNILLTAYSKAGNLTGTFTTFKRMLDEGIETNPHTFGIMMGLCANRGDVSHVRDLLDLAQQHKVQITAPLIDTVVEAYCNNQEWDMAENVAETCLGLDVRGSRVRMWNILLWNYAFRMDLEGISRVRSRMDAAGLQPDDMTYAALMLSLVLIGQTDSARRILRTLHRGRRVYATEFHYAVILYGYLKDRNRDMVHIVFREIKDRFNQPGLGSRLLVLRSQIQRDLQLVAHGGRAGDNASLRLENSEKFLAEVLADYHTTKLATKYPLLGSGRMSARKAFPAVYYEYIISAYGMKGAYKSARKLFDEYIASQPPRDPENDHDIAPLRLLSALMLAHLKADQYHKVEECWNLVFPRALKIASPSSPDIDEWLSSQLNQVKPPLPSHAELVVNVDTEVEFPEKKKLSILPAYRFMLSRPLSLYMRSLAYGNEVWKISKVIAKYVGAGFAMTTFNWSTFVQMLASSDRLSDQIEAFSVFEERFMPNFPGWNNLRRGYGLRPPEVPATIDAMEDPRRAKPPNVLGKESRRYWSKIQPDFMQPTYVSMVYLAAALQRLRERSIYDGGAELQAIYDAAPTTVAAVADMPYLREKFQGVLLRRRQEQGDQLAGRDHFVWTGGILGVGGLARSDSEVEPAPESTEEDSSATEDESTASKQTDRLSPIAESSDVTDVQYAEAEPSPFKKTIDYPDEYDIEAETLLEERDKEMGTKEELMDDESLVEYDDEDEADDLEDTEFEEGEGEEEEDILDADDQDDVYDPEGEGETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDT1</accession>
    <name>A0A317XDT1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_530081</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473465.1">
        <property type="nucleotide sequence ID" value="XM_025610607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDT1"/>
    <dbReference type="STRING" id="1450535.A0A317XDT1"/>
    <dbReference type="GeneID" id="37112750"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY96704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="407" mass="45337" checksum="958A80EE2983E018" modified="2018-10-10" version="1">MPLTVCVNDQQPCYSGNETIRGRITFETSKPIDIQDVRVTFSGCAKAKVQKVKGSAAPTTSYRSKCMLFEKDAILWHPNGETVVPGTYEWPFEFVFPSQVLGSSKWPETLPFRSDANHPLPPTFAAETADVLRKLTCNIDYQIQAQVFSPQRGFLGKKPPLFSEVVRLNFMPFSARLDMKRNNNSSALYQQQKEQVFNLRSMLLLPENRGRSLKLQEKIQSWLSSSQLPRFSFKASFTCAYRVIQSTPLPCFLEITPLLEDSSVTSPPEILMQSLSITVLSQTAARAAPSLMGALSGQVDERIEILSKTSLGMPVSGTVDLAQVFGPLIFRHTEVSFGTFNISRTYRLCATFVFECAGNMRTFDVTDIPITIFADFGEPDKIQSSVEHSPPSYTSGSILSTETLEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE53</accession>
    <name>A0A317XE53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_455823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472793.1">
        <property type="nucleotide sequence ID" value="XM_025607676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE53"/>
    <dbReference type="GeneID" id="37109819"/>
    <dbReference type="OrthoDB" id="4206979at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="128" mass="14855" checksum="273B1695F8A99998" modified="2018-10-10" version="1">MNPAFSQPLYSISEEITPIDDYIRRHGGTSSNIERLPSRLQQSKRSSIDLKQQLKDLTYEVSYLKAELQWHKESKQALLEFKEQVSEIFHRIEDALVQATIRLTEAEQRYLNLWGLNTGGDMDGLNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF44</accession>
    <name>A0A317XF44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_506763</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472399.1">
        <property type="nucleotide sequence ID" value="XM_025609586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF44"/>
    <dbReference type="STRING" id="1450535.A0A317XF44"/>
    <dbReference type="GeneID" id="37111729"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="472"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY95638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="481" mass="52483" checksum="C104860C603C220D" modified="2018-10-10" version="1">MAANFQHPFQCFQFVPRPNSNLLIGSAGSKLYSYSAESGERLAVWPQEVDSTTANPVDADSVSEQGPPGKKRKVSTLETQTNDKSAWSSIPIVTTTTTGEYVVALTAEDKCVRVFQLQEDGSFTQLSERVMPKRPSAITLTSDDTTILCGDKFGDVYSLPLIPSDKLPVITKALRSAKLSHPAATNLTVHTKGNRRALEQQLRLASEGKKDEKSAGPTFEHTLLLGHVSLLTDMAYVSLSVDANKKRSYILTADRDEHIRVSRALPHAHVIENYCLGHTAFISQLCVPQWAPEYLVSGGGDNYLLVWKWAEGRILQKVSLVDESSQAAEVAVHGIWATSLGDLRVILVALHGSSLLQCFTLEADGTLKAQSPIQLSGNVLALTPIEKDNTILVSVDPIRQPDTTQEWRASPSSPSTLIEGFHVKPGTDSLEWEPAAATVAEKINSAGTDEVSTTTEDKQRKELNDSLYGLGHLRKRKGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFD7</accession>
    <name>A0A317XFD7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sequence orphan</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_561937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473248.1">
        <property type="nucleotide sequence ID" value="XM_025614253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFD7"/>
    <dbReference type="STRING" id="1450535.A0A317XFD7"/>
    <dbReference type="GeneID" id="37116396"/>
    <dbReference type="OrthoDB" id="275936at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038781">
        <property type="entry name" value="C365.16-ike"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37845:SF1">
        <property type="entry name" value="SEQUENCE ORPHAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31278" checksum="94AE9E98BB9EE925" modified="2018-10-10" version="1">MSPDRVKAQPLHTGTWNNNYSRQLAGDFVAGSLSATIIAPVITVIDRSVVERLSSNQSLLSTLRTHAICSILEPRKFYISRPFFIAWSLYAATYVTANATDTSLSHFPKIAEKSTIANIAATFSFLPTYAVNVSMGILKDIRFSQIYGDPKTIHKRPPSIPRAAYMAFLLRDSITISSSFTLAPQVASFIPDWITTDLHAKRTITQLALPALVQYLNTPLHMIALDLIARPQVATMAERSALIRSGWVQSSSVRAARTLPAFGVGCVVNADLRALFHEQWMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFX1</accession>
    <name>A0A317XFX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">L-cystine transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_455402</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cystine(out) + H(+)(out) = L-cystine(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:66172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:35491"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:66173"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cystinosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472461.1">
        <property type="nucleotide sequence ID" value="XM_025607653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFX1"/>
    <dbReference type="STRING" id="1450535.A0A317XFX1"/>
    <dbReference type="GeneID" id="37109796"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000016">
        <property type="entry name" value="Cystinosin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000071">
        <property type="entry name" value="Lysosomal L-cystine transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00951">
        <property type="entry name" value="2A43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0458">Lysosome</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0769">Symport</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY95700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="33268" checksum="AEB72D725015FAB9" modified="2018-10-10" version="1">MATQLEVFVRALSRLLGWIYTFCWSASFYPQPINNFRRRSTTGLAIDFPTINVLGFVCYTIYTSAFLYSPVIRHQYAARHPLAEDPTVRFNDFAFALHAVVLSFITYTQFWPFIWGFKVSRYQRVSKPVAGLFWGSIVAVAVVIFIVLAKSPDQGYDPYSWEWIDVIYSLSYVKLIITIVKYVPQAWVNYKRKSTHGWSIDQILFDLSGGVLSLAQLLLDSGFQNDWSGVTGNPIKFLLSNVTIFFDMIFVVQHYVLYRDAEDRKGKDQNPSDRTPLLSESTDVPRADSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XH16</accession>
    <name>A0A317XH16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_6958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473111.1">
        <property type="nucleotide sequence ID" value="XM_025617603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XH16"/>
    <dbReference type="GeneID" id="37119746"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="69" mass="8219" checksum="A0882D19BEDB0213" modified="2018-10-10" version="1">MFPCDHLHSHIHTHALKLCRRHPLFLLSLCLSYLSVCLFIRYMRLSLGHFSSGIRIKKRYIVLAWHFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317USN9</accession>
    <name>A0A317USN9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_356535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000064">
        <property type="protein sequence ID" value="PWY65014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461365.1">
        <property type="nucleotide sequence ID" value="XM_025607133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317USN9"/>
    <dbReference type="STRING" id="1450535.A0A317USN9"/>
    <dbReference type="GeneID" id="37109276"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY65014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15374" checksum="C7838CD91B18F3A4" modified="2018-10-10" version="1">MLYNALIRTHHITSRKKVSALKRAADIHNCFVLLRSGGCPGIMYVEAKDKDAVESWVTVVRKLRYKDFQLATRPGPLHDENQPEVRDQKQIPLSRKQDTRAGVSEVESVKEFGSLMEQRGVWKWWRKGMGYMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UTX7</accession>
    <name>A0A317UTX7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial genome maintenance protein MGM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_480401</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
            <location evidence="1">Mitochondrion nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000066">
        <property type="protein sequence ID" value="PWY64776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461322.1">
        <property type="nucleotide sequence ID" value="XM_025608793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UTX7"/>
    <dbReference type="STRING" id="1450535.A0A317UTX7"/>
    <dbReference type="GeneID" id="37110936"/>
    <dbReference type="OrthoDB" id="17164at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000262">
        <property type="term" value="C:mitochondrial chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009446">
        <property type="entry name" value="Mgm101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31404:SF0">
        <property type="entry name" value="MITOCHONDRIAL GENOME MAINTENANCE PROTEIN MGM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06420">
        <property type="entry name" value="Mgm101p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1135">Mitochondrion nucleoid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY64776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="177" mass="20254" checksum="2E29CA60993FD902" modified="2018-10-10" version="1" fragment="single">EDKIDWTRSFHGLSATPFPKECADILLAPTDPNEVEIKPDGILYLPEIKYRRILNKAFGPGGWGLVPRGESIVTPKMVTREYALVCVGRLVSVARGEQDYFSPDGIPTATEGCRSNALVRCCKDLGIASELWDPRWIRKYKAQYTREVFVEHVVNKRKTKIWVRKDDQVGYPWKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXD8</accession>
    <name>A0A317UXD8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_591309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000056">
        <property type="protein sequence ID" value="PWY65658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461485.1">
        <property type="nucleotide sequence ID" value="XM_025616103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXD8"/>
    <dbReference type="GeneID" id="37118246"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY65658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="423" mass="44147" checksum="006242DB7A58B0B9" modified="2018-10-10" version="1" fragment="single">MSPSDTGMGGANPTEGAMALESCPVDIIFPKSILGTPSVISPGSYPTSVELAWNTTTTVTSGGSTSVSTGTTRYIMPTYIPLSPVTIGSIYYYDWNITDPHVTSTHGPLIPSINLPPVTIIDDPNPLNESGVTHSPLGTRVINIPPWPWSTGGSVYPTIIFKQGSPPGPTCTANCGHKCYDFCDGPCLNDCGRESSSSFIDPLDTNPPSVTKCTGPGCVNGKCTGQGLCIERGCTGVDCHNRDHGCIGDDSDDSTDDDDSSDSDDDISIGICFGLDCLSWGCLGLDCSSSSHTCTGHSCRVVTCTGPGCKDGICSGHACHSEDTDCESEEADSCTEYISSTLINPTSTYSTTTVTSQCSTITACSASPTTVTSTITGDSLVEGTISAVDSMVSEDPAMWTSILDDLDSFYPMAFATNYTTESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXM4</accession>
    <name>A0A317UXM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_540620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461693.1">
        <property type="nucleotide sequence ID" value="XM_025612951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXM4"/>
    <dbReference type="STRING" id="1450535.A0A317UXM4"/>
    <dbReference type="GeneID" id="37115094"/>
    <dbReference type="OrthoDB" id="5420143at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF2">
        <property type="entry name" value="EXTRACELLULAR PROLINE-SERINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_8G07090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016381083" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="156"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY66495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="252" mass="26702" checksum="39FE80BE91281FCD" modified="2018-10-10" version="1">MHLSTPLVFALASLASAITINQPGLNASYPAGSTVLVNWTTVDTDPTYFSLYLWNFVYWPPTYVPLAIDIPTADRAYPVQIPCDTTPEWGYQISGINGTNVYIIYAQSEKFTVSDPINSTCVDTPAPTTAAASTCGAPSTVYVTVSPTASSSALFHHHHSHHHHSTPRVPTPSPTTTPSSSRYVKPGIVPKTIGWCSDYSHPVTLDKVPTPTDVPSSVSSVAEATATSDVIVQTVTTTLGVAASGDAGCPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UY39</accession>
    <name>A0A317UY39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_613714</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461704.1">
        <property type="nucleotide sequence ID" value="XM_025616709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UY39"/>
    <dbReference type="STRING" id="1450535.A0A317UY39"/>
    <dbReference type="GeneID" id="37118852"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="24"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY66506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="533" mass="59807" checksum="8433A42009B45236" modified="2018-10-10" version="1">MGLSLFSSKEPYFGLTGGWLTVWITVACATDMTLFGYDQGVFSGVVVTENFLETLDLVGSGKTQVLSTVTAIYDVGCFFGAILAFSFGERLGRKKSIIWGTSIMAVGTILQASSYNLAQMFVGRVVSGLGNGINTTTAPIWQTETSSARWRGRLVIFEMLMNLAGYCLVNWINYGLSFHGGSVAWRFPIAFQFFFIFVLFATVPWLPESPRWLMAQGRIPEAIEVIACIEAKSVNDPYISTQRNEIEYSIQYERENAVSWRDLFLGKKTNDTKTLRRLVLGAGTQFMQQFEGVNVISYYLPTVLMESVGLSNKMSRLLTACNAVSYFVFTSGAVLLVERWGRRGLMMISTIGQFFSFLLITIMLRFSGTQPNGEKFASASIVFFFLFYIAFGMGMLGVPWLYPTEISSLPMRTKTAAVSTATNWIMNFVVVEITPIGIQSIGWKFWVIWTVFNAAFLPVIYLFYPETANRTLEDLDAYYRSNPPLIVINDPDAISVKRPLKYIQHEDEELRKTTKQGGANLSKVDEQTVEHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UY55</accession>
    <name>A0A317UY55_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_613772</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461724.1">
        <property type="nucleotide sequence ID" value="XM_025616715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UY55"/>
    <dbReference type="STRING" id="1450535.A0A317UY55"/>
    <dbReference type="GeneID" id="37118858"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF113">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY66526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="385" mass="43120" checksum="C06F4EBC1F39778F" modified="2018-10-10" version="1">MTVNRNVAVKALPPSFFALSLITVLLRCYVRMRVTRAFGWDDGMMIIALIFYGMFCGCMVTGGVYGTGMHFDQLTTSHRVKAMMFWWLCEIGYCVSSIFCKCSICIFLARITVKRPHLVFLYIIMTLTVLMGLVLMFGLLFQCRPVTYFWTRVAFDPTIQGTCVITEVVEALTYAYSAVAAVCDLAVGIVPFFIIWGLNMPFRRKVAAVAICSISCIACSAVIIRFPFVRTFADMDFLYKTYEIAVWSNVEVGLGIFAGSLATLHPLLRHIRSSWTQGRLKRLTSRDTSEQVTPPVDFVSVSDYPSPSVEIFRPGNVMNITTTVQREELGLGIGEGSQLSTRGSCDTDMRANDILVQQTFQINTGRPSRDWDPWTNTSEAGDDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V098</accession>
    <name>A0A317V098_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">dTDP-D-glucose 4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_551339</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461801.1">
        <property type="nucleotide sequence ID" value="XM_025613540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V098"/>
    <dbReference type="STRING" id="1450535.A0A317V098"/>
    <dbReference type="GeneID" id="37115683"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="25"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY67079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="387" mass="43926" checksum="8BE566BC96C2F554" modified="2018-10-10" version="1">MTVQELGLSNGESADNDTGNVKTILVTGGAGFIGGWFVRHLLRVYGERYTILCFDILDYCASKRNIQPVEHLPNFHFIEGDLCNPLSVTSIFEQFRVDAVVHFAANSHVDHSFVDPIPFTQNNVTGTHILLEAARKARTVRRFIHVSTDEVYGENEPGQNYAFTEDDRLNPTNPYSASKAAGEMIVNAYLHSFHMPIIITRCNNVFGPYQYPESKIQASPMTGRSMSNVCAELIPKLAMQMLHSKRMTVHGDGKAMRGFVFASDVMNAFDIIFHRGVVSETYNISSREQIQVRDVAEKILQWFHPGCSEREQYLEMVQDRPFNDRMYWTDDSKLRLLGWTEQVSFDDALAITLEWYRSYGDTFWPKAEPACEMNGGNIAHVELTNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V332</accession>
    <name>A0A317V332_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_300670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462158.1">
        <property type="nucleotide sequence ID" value="XM_025606744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V332"/>
    <dbReference type="GeneID" id="37108887"/>
    <dbReference type="OrthoDB" id="4225515at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="554" mass="60400" checksum="5928591C5E4CE91B" modified="2018-10-10" version="1">MADGYSRLPGEPNAFYSSRNRSQTAVGVPPSTPTKRASSFYPNRPGIVDESNPDPFYLEHTLAGAAPWGTRRPGSRDARCSEEGYPYSMLSSVYSTDIPFAPTARGEATRLRSNINRSTLSVVELEHQLGLQQVAARPWGAPTVNHDHGSFSSVHTEATPDLTPSSSFSSNYSAPIYPENFPPSEPLPVPPPVPSPRNNVYPCSSTPLNQSQTTLCTQSSTPVRKGKPQTVAPNASSDTLVMHRVDSHDAPPHLGKPLPSLPHGAGSNIGHSGRKGPPPPIRPPIAPSMISPPSRINPVTMEPHASHFDQAMFIPANDCPSPVPSPGPSSPALERYPTANSGRDRPSTSASRAAYCEQSVWESDSDSETADPKSLSRKPMDTLKKVRSRVHLRVAKSAPKLQPTQAASQQTHPLEKYPSMPDQPPEELCPSPTRHTVKARSRDGLRNAPTLRLVDPSVTSLPLPQSRRGSGQVRAIDIDRTTAAAMQAKSRRRPRSESKRSLPPEREKVYTFCREDRSDAILSLARPPLYKRLWDSLRVLGCHGEIPPRSRRPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3T9</accession>
    <name>A0A317V3T9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_305701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY68011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462060.1">
        <property type="nucleotide sequence ID" value="XM_025606785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3T9"/>
    <dbReference type="GeneID" id="37108928"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016190004" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY68011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="570" mass="62757" checksum="CBCBF392C4AB41DA" modified="2018-10-10" version="1">MSKFLLWTISAAALARAATLEEVCTSAYAKAAVPVSGLVPGVVTSPSSVTAAPVYNESTAGSNYYPAGTYDYCNITMTYSHAGKDDSVLLQFWMPTPDDFQNRWVSTGGFGFAINVASNVPAGLPYGAVAGRTDGGFGSFDTQFSSVFPLVNGTANYDALYMFGYQAHHEMSSIGKAFTKNFYSMTDKLYAYYQGCSEGGREGWSQVQRFPEEWDGAVIGAPAIRYGQQQVNHLVPQVVEQTLDYYPKNCAFSEIVTLIIDACDALDGRKDGVVSRTDLCQLNFDLTSTIGKPYSCAASTSMGVSTPAQNGTINVETVKVAQTILDGLKDSEGRQAYFWYRIGSEFTDAETAYDSTTNTYGIDISELGGEWVTHGLQLLDLDNLSNLNNVTYDTLRDWMLEGLQRYEDVLQTTWPDLSRFQAAGGKVIHYHGESDNSIPPSSSIRYFESVRDIMFPNATYNASVEAVNEFYRLYLVPGASHCNTNSLQPNGPYPQNSLGDLMDWVEKGVEPVTLNATVLSGDYEGEEQQLCSWPLRPLWKNNGTVMDCVYDQKSIDTFLYDLDAYDIPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4I8</accession>
    <name>A0A317V4I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_300010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462330.1">
        <property type="nucleotide sequence ID" value="XM_025606735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V4I8"/>
    <dbReference type="GeneID" id="37108878"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="80"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY69015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="564" mass="59929" checksum="DC78718D74842D49" modified="2018-10-10" version="1">MTVAASSPGPLGAIVDERTPLNTSTQDAIQSTTAPSYSSVAKGPISDVPSGHGSDEERSLLSPAKTRANDVKTLTSISTVVGVLLLGEFISNADMTLVMATTGKISSEFDRLRDASWLATAYTLGLCATQPMYGKLSDIHGRKPLLLWAYVFFGIGCVISGIGRGMATVILGRAISGIGGAGTMAMGSIIITDIVPRRDVAHWRAYINIAMTLGRSAGGPIGGWLADTVGWRWSFILQGPLSAMAALLVIWKLKLTSPVTEKSIRRVDFLGTFLLAIGIIATTIVLDQAGRSFAWASLSTAILTTTSVSAFVAFVLVELYVAPEPIFELRILRKPNVTPSYLIGALQITAQVGMMFSVPLYFQVTSQASATVAGGHLVPAVIGNTLGGLIAGAFIRRTGHFKVLLILAGLIASVAYLLMFLRWSGHTGFWESLYIIPGGLGTGFASAAAFVSMTAFLLPQEVAMATGGYFLLFSFAMTAGVTVTNSVLGTVFKRQMEQHLTGPGAKKVIERALSDTSYINGLEGHVRQIVVKGYVAGLRYTYLFSLTLSILGSFIAWTVRKHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5E1</accession>
    <name>A0A317V5E1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_540301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462129.1">
        <property type="nucleotide sequence ID" value="XM_025612891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5E1"/>
    <dbReference type="GeneID" id="37115034"/>
    <dbReference type="OrthoDB" id="4497323at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14712" checksum="6F812018724D643F" modified="2018-10-10" version="1">MASAHQDNFTIDPSVLYNEAPLGNHHSEPMRGTNNQEREGQDGKQGERKGDEECCPPSVEPIRMIIRGHIFNLDNGVPEHIQDELWALFGKKKLTSEKIPEHLKAYGYTAEQFEQFAKEDAKYGKMALEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V697</accession>
    <name>A0A317V697_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase F0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_560702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462562.1">
        <property type="nucleotide sequence ID" value="XM_025614177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V697"/>
    <dbReference type="STRING" id="1450535.A0A317V697"/>
    <dbReference type="GeneID" id="37116320"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="293" mass="33045" checksum="604EC5E7C15FCD3E" modified="2018-10-10" version="1">MTNQTPDNNPFAKRESHDRFSLGTYRVLVPLSWALVVIVGIYYSSHAPDVKHGHTIWKQANKHITPFSLSTVIGGIYWVIVLLSQVGYVYHLFSNDAVVATAAANVGSHFILNNLFIFAWILLWTRNHFWGSEIILIAHFLNQKTTYWRHRTLPSISHFAVVAAPYAWTLITLFWNGAVAVNSNSLPARIVANVFIWVLFALGSAHILATQDDILGYSLSFLTLALAVKQFGVKIISLQWIFAIVIFAVFFAESIYITLTRYSGRNVFLRRAEQPAATDREREPLLNEPAQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7D5</accession>
    <name>A0A317V7D5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_540045</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462386.1">
        <property type="nucleotide sequence ID" value="XM_025612829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7D5"/>
    <dbReference type="STRING" id="1450535.A0A317V7D5"/>
    <dbReference type="GeneID" id="37114972"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="12">
        <location>
            <begin position="48"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY69181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="387" mass="43450" checksum="3CBADFD6DCD25417" modified="2018-10-10" version="1">MPKVKQQKRNSASKASPYADAAAKTKAANSIFKMNTDLGQHILKNPGVAQRIVDKAELKQSDVVLEIGPGTGNLTVKILEKAKKVIAVELDPRMAAEVTKRVQGTPAQKRLDVILGDVIKTDLPYFDVCISNTPYQISSPLTFKLLATSPAPRVCILMFQREFALRLFAKPGDKLYSRLSVNAQMWAKIDHIMKVGKNNFKPPPLVESSVVRLVPKNPRPQINYDEWDGLLRIVFVRKNKTIRSSFLGKSTVMDMLEANYRTWCAQNDVPVEDGPADDTEPDAMDIGTAQADEEDEGDDEPDEGMEVDDDDDVPDFFKEQTSARIQEALKSRPSRKKRGKVAELVREKVRQVLEDDTGLADKRARMCDENDFLKLLWAFNQKGFHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBC7</accession>
    <name>A0A317VBC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vacuolar ATPase assembly integral membrane protein VMA21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_539846</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462668.1">
        <property type="nucleotide sequence ID" value="XM_025612789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBC7"/>
    <dbReference type="STRING" id="1450535.A0A317VBC7"/>
    <dbReference type="GeneID" id="37114932"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY70377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="108" mass="11471" checksum="31034BC1A943F41B" modified="2018-10-10" version="1">MATRRIAEKSSPKDVATTSGSEKPSDSDVTPAVPTNVIMKLLGFSVAMVVVPIGMYFVTVDFGASATVGGIVAAIMANVVLFAYIYVAWKDDQAEREADTKQKAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBT5</accession>
    <name>A0A317VBT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_267106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462743.1">
        <property type="nucleotide sequence ID" value="XM_025606532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBT5"/>
    <dbReference type="STRING" id="1450535.A0A317VBT5"/>
    <dbReference type="GeneID" id="37108675"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY70849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="339" mass="36415" checksum="D093512EF0BDA2BB" modified="2018-10-10" version="1">MADETILVTGASGFVASHIIATFLAAGYRVRGTVRSGSTAETVQSRFAPEHVERLSFAVVPDMAASGAFDKAVEGVTGVIHTASPFTLKVTDNETDLLQPAIQGTLNILTAVAAQGPEVRRLVFTSSFAAIVDISQGLRPGYRYTEADWNPCSYDEAKASTDASFVYCASKALAERQLWEWVDAHSPNFDVVAICPPWIFGPSVGAPSPGKNGLNESSEAIWRLVNGSLTSIPDYDYIAFANVHDAAAAHYEAYVRPEAGGERFLVAGGRFLYQDACAILRRRFPQLADKIPGCSGDAAVVETYIADGGKAQKVLGLEYRDLEDTLVETVEDLLERVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCF3</accession>
    <name>A0A317VCF3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCCH zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_569409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462854.1">
        <property type="nucleotide sequence ID" value="XM_025614735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCF3"/>
    <dbReference type="STRING" id="1450535.A0A317VCF3"/>
    <dbReference type="GeneID" id="37116878"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000022">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="373"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="428"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY71099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="492" mass="54122" checksum="25CA2B4635E30A95" modified="2018-10-10" version="1">MTEDQDLMAKISQLAGQINRHKTQRSQSESPYSSEIPSGQHVSRHVPHRGRGWAPYRGRPYARGRHVAPHRHRTLILNNTTTSGTPGSTTPAGTMTDTDGEARSATPNEWVVKHDRHMQLINTSIYDKEAQARTKAIEESRQAKAHKRARVEQARVLNYAQGVGRTYSAGFAAPQVSTTAEPSAEFQVFVNDIPFRVSRGGSKLIRVSGACVQDALVKRTSLQVIDDPNTANATPKKVTVAGVAFVRSKNGNLHRLGAVTSKRKPMAVKKKDALCQRFTTTGTNAFPTIGPGIALIRVLKPLGSCYKGPTCPYTHDPNKVAMCKGFLQTGQCNAGISCDLSHEPSPHRSPACVHFLRGRCSNPECRYAHVRVTPGAPVCRDFAVLGYCEKGAECDERHVHECPDYANDGVCNKKRCRLPHVDRAGQIRKNTASRTDVMIHAEESDASSEEEEYDEIDTDDVDSDDLDEDEQELIAGESDTGEVSQQQDFIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VD33</accession>
    <name>A0A317VD33_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_539302</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463129.1">
        <property type="nucleotide sequence ID" value="XM_025612679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VD33"/>
    <dbReference type="STRING" id="1450535.A0A317VD33"/>
    <dbReference type="GeneID" id="37114822"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY72176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16635" checksum="DA5FC4B064E7DE86" modified="2018-10-10" version="1">MYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDISNAKSFQNTRKWIDDVRGERGNDVIIVLVGNKTDLNDKREVTTAQGEEEAKKNGLMFIETSAKVGHNVKQLFRRIAQALPGMEGEGNRGDNQSLFPPAHPTIITWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDW7</accession>
    <name>A0A317VDW7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_539277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463098.1">
        <property type="nucleotide sequence ID" value="XM_025612670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDW7"/>
    <dbReference type="GeneID" id="37114813"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14493" checksum="01680A255CA26B75" modified="2018-10-10" version="1">MMDSPSNTSTLNPIPPSKLPDPTKPKADFLESSFFAKPNRRLPSPAEVKALSRDFTKSRQQPVVFEHLNLIVKLGRTVTVAEAQCLWMLRRVFGDTVPVPEIYGWRTDEDYVFIYMELIDGRTLHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VEN7</accession>
    <name>A0A317VEN7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Formate dehydrogenase</fullName>
            <shortName evidence="6">FDH</shortName>
            <ecNumber evidence="2 6">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_539487</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 6"/>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462935.1">
        <property type="nucleotide sequence ID" value="XM_025612711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VEN7"/>
    <dbReference type="STRING" id="1450535.A0A317VEN7"/>
    <dbReference type="GeneID" id="37114854"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05302">
        <property type="entry name" value="FDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="7">
        <location>
            <begin position="184"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="229"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="285"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="369"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY71537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="419" mass="45642" checksum="71F64DEC372E8E9A" modified="2018-10-10" version="1">MVFMRSFSRQLRRPATSLLSTKGAFAPAASNPFRAAPLANSIAGARTLTASANLQGKVLMVLYDGGEHAKQQPGLLGTTENELGLRKWLEEQGHTLVTTSDKEGENSTFDKELVDAEVIITTPFHPGYLTAERLAKAKNLKIAVTAGVGSDHVDLNAANKTNGGVTVAEVTGCNVTSVAEHVVMTILTLVRNFVPAHEQIRRGEWDVAAVAKNEFDLEGKVVGTVAVGRIGERVLRRLKPFDCKELLYYDYQPLKPEVEAEIGCRRVDSLEEMLAQCDVVTINCPLHEKTRGLFNKELIAKMKKGSWLVNTARGAIVVKEDVAEAIKSGHLRGYGGDVWFPQPAPADHPLRTVQGPWGGGNAMVPHMSGTSIDAQIRYANGTKAILESYFSGRHDYRPEDLIVHGGDYVTKAYGQRNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFR5</accession>
    <name>A0A317VFR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Kinesin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_255381</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463064.1">
        <property type="nucleotide sequence ID" value="XM_025606460.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VFR5"/>
    <dbReference type="GeneID" id="37108603"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01233">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000357">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049780">
        <property type="entry name" value="PH_KIFIA_KIFIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="14">
        <location>
            <begin position="8"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="13">
        <location>
            <begin position="1521"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="619"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="743"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1424"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1476"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="767"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1424"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1490"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="112"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY71828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1645" mass="183099" checksum="FA5F373705FE7EF4" modified="2018-10-10" version="1">MAPAGGGNIKVVVRVRPFNSRELDRGAKCIVQMKGSQTVLTPPPGADEKARKAGGGKGAVEGPKSFAFDRSYWSFDKNAPNYASQDNLFLDLGVPLLDNAFQGYNNCIFAYGQTGSGKSYSMMGYGKEFGVIPRICQSMFERITSIQQDKNLGCTVEVSYLEIYNERVRDLLNPSNKGNLKVREHPSTGPYVEDLAKLVVRSFDEIENLMDEGNKARTVAATNMNETSSRSHAVFTLTLTQKRHDSETSMDTEKVSRISLVDLAGSERATSTGATGARLKEGAEINRSLSTLGRVIAALADVAAGKKKNASMVPYRDSILTWLLKDSLGGNSMTAMIAAISPADINFDETLSTLRYADSAKRIKNHAVVNEDPNARMIRELKEELAQLRSKLGGGVAAAAGGGAGGVAGAIPAEEYYPPETPLEKQMVSIQQSDGSVTKVSKAEIVEQLNQSEKLYKDLNQTWEEKMAKTEEIHKEREAALEELGISIEKGFIGLSTPKKMPHLVNLSDDPLLAECLVYNIKPGTTIVGNMEQGGHVEIRLNGSKILDDHCRFENVDNIVTIIPTEGAAVMVNGLRIDKPKRLKSGFRIILGDFHIFRFNHPQEARAERVEQSLLRHSVTTSQLGSPAPNKTHDRSLSKTGSEVDGDSSRADSPMPSQRGRESDWFYARREAVSAVLGPDQISHMPDDELDALFEDVQKVRATRRGLMENEEDSDSLSSFPVRDKYMSNGTIDNFSLDTAITMPGTPRPIDEDDGQNGGDATLQSVRQDMQRQLDRQKEEYQDKLRNAEASSTQGVDDLRSEKARMEEALRTAKEEFEEQLKKQKEAFESHMKDLGQPVPKIYENGFAKLDARELEVASTVYRHWSQQNYVRMAEKVLQHASLLKEAQVMSHIMDKNFVFQFAIIDHGHNMASSYDLVLNGISGDEDVVLDDAKKPCVAVRVIDFKQCVIHLWSIEKLQRRVQAMRQLHQYIDRPDYIQHFKLENPFSESCSPQYSLVGDADIPLTAVFETRVQDVSVEVISPYTQNVIGIIRLSLEPSSAQAPSSTLKFNVVMRDMVGFAEWEGSDVHAQLFLPGISDEGGATTTQMISGFDETPVRFESVHSMSLPLSSPRTAALKICVYARVTQMHLDKLLSWDDMRDSAEPAPQKRKTPRIAETEFYSEERHDVFARAQVLELAETGEYLPVEVVQSNSLDAGTYQLHQGLQRRILVNLTYSSAETLPWDDITSIRVGSVRLLDPWGKIPDQDLQTPDVPLKFVQEPNVKENADGTSNITIIGQWDSSLHGSLLLDRVTADKYRVQVTLRWDLISSRLQDPVPFEIDLTLQIQGRTYVRPQSMFKQFFNSTRIVHSTVRMFSLVVRPVSAKRAADLWRMNTQNDYVKGEEFLTTWAPRKVSLVRDYVAARKRRRRVAELNAAKGALSATSLVASPSRSGRSTPLRSQERVDRRTKLLQKYVDLWTRKTDPIEAILVRSNTEPPAGGAAFASRAKPFSSSDDGSSVQDEASLKPRFVATVQALPKNTSSLKSGYLLTPDDTNSQWVRRFVELRRPYLHIYSVPDGDEINAINLRNSRVDHAPDFARLLDGPGAGSDRGTSPRGRPNVFAVYGAQNTFLFAARTEAQKVEWILKIDEGYFSSSGARAMANNNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGL2</accession>
    <name>A0A317VGL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanyl-tRNA synthetase class IIc N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_539242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463333.1">
        <property type="nucleotide sequence ID" value="XM_025612663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGL2"/>
    <dbReference type="STRING" id="1450535.A0A317VGL2"/>
    <dbReference type="GeneID" id="37114806"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanyl-tRNA synthetase class IIc N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="53" mass="5768" checksum="3DB0CE222AACE534" modified="2018-10-10" version="1">MNQFKSIFLGTVDPNSDFANLKSAVNSQKCIRAGGKHNVSAMSIINAKRQTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VI50</accession>
    <name>A0A317VI50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_258855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462918.1">
        <property type="nucleotide sequence ID" value="XM_025606471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VI50"/>
    <dbReference type="STRING" id="1450535.A0A317VI50"/>
    <dbReference type="GeneID" id="37108614"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001332">
        <property type="entry name" value="Similar to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="11"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY71520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="281" mass="31277" checksum="76FFFE6DBD2479E0" modified="2018-10-10" version="1">MAHNNSPSPSIEVKNLSFKFPDGSPGLTDVNLQVPAGSRTLLIGANGAGKTTLLRLLSGKRLAPTDTITVASKDPFKDGLEGVTYLGMEWVLNNIVRSDIDVPTLLASVGGNAYPDRRDELVEILDIDLRWRMHAVSDGERRRVQLAMGLLRPWQVLLLDEITVDLDLLSRANFLAFLKRETESRPCTIVYATHILDNLSLWPTHLVHMHLGTVKRWGSIEKFREEVKESSQNSQLGELVLKWLKEDLKSRGPRNGYQGQAKTYPSLDGLGGYGLEKRPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPJ5</accession>
    <name>A0A317VPJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative isoflavone reductase family protein CipA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_605487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463818.1">
        <property type="nucleotide sequence ID" value="XM_025616492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPJ5"/>
    <dbReference type="STRING" id="1450535.A0A317VPJ5"/>
    <dbReference type="GeneID" id="37118635"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY75191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="303" mass="32835" checksum="67F6779CAEAD5988" modified="2018-10-10" version="1">MSRTIKNVAIAGASGNVGARVLSALIDLKFNVTVLTRSSKSFPSTVQVKVVNFDSLESLSAAIAGQDAVIDTTFSLEIETPLRLIHAAAENGVYRFITSDFGLDPDLPGVHDMPVFARKKASYEAVKRHAAENRLTYTLVACGAFLDWGISSGFAGLDMKGKKAFIFGDGNNVVPWTTIDEVGVATAHVLLHPQETLNRPVYVHSVFMSQNQLLATSKAILGADGWETTYNDMDQLFKNALADLEAGNISTSTFEVQIQYCLATKALAHPWARDDNLLLGLKGWEMEKVEGLVQTIVQEAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPT4</accession>
    <name>A0A317VPT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prenylated rab acceptor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_198752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464186.1">
        <property type="nucleotide sequence ID" value="XM_025606088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPT4"/>
    <dbReference type="STRING" id="1450535.A0A317VPT4"/>
    <dbReference type="GeneID" id="37108231"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="375" mass="40670" checksum="095EEC1226A4121C" modified="2018-10-10" version="1">MPRWGRPPGARVGRQTRRADPWVDGAVRIEEIDSGGEDAYIRRDVSSLYARQSAGLDEDGGSRLRRRRMGYDYADEVASVDGVDYDLYEDMDSTVAYAVQLAMKDKEERLVDQALERIRHAQKQGQKNVRLSGRELEALERKRVQANRTPDSEYRASIPRGSPGSNRPLRPPESPSSKIGAQRSGSSASLPNKHGMPSSLSANNAAYAFWARTLGASAGAQTSARSPSARGASKQTPSRTPLQPAYSPDRLASVPLARTSGSVNPPAFTRSLPDDPHWVPPYPVSYPREPPPPLYPTDPRHSGPMPYTSGYSSVFDESLRSSGRGPAASLGELGFAAGGTRGGEGEEVSSSDDSAKVVERRVPIGRGSRQRSNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPY8</accession>
    <name>A0A317VPY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_207308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY75995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463992.1">
        <property type="nucleotide sequence ID" value="XM_025606127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPY8"/>
    <dbReference type="STRING" id="1450535.A0A317VPY8"/>
    <dbReference type="GeneID" id="37108270"/>
    <dbReference type="OrthoDB" id="10018600at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012332">
        <property type="entry name" value="Autotransporter_pectin_lyase_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016310985" evidence="1">
        <location>
            <begin position="17"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY75995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="458" mass="48198" checksum="BE1FB7CDE9AFD19E" modified="2018-10-10" version="1">MARLPLLFACISLALASLTVVDPSDYADLAADAFDNALEVDYTTNNGGPSYLLYNVTGPHYYADEDGEVAHQTLSVDANDTSVLVATDGAVVNVSYTDIIKQGYSTWLNQASFFGVNAAINVANASTAYIDHSNITVHNGAANVYSYGTGSTVYVSDTDLYSSGPVSHGLYASGKGTIYGSNLRHYSGGERCSSFSGDNPAGYIYVTDAVAHTAGIGSAIFYTLGESYGRDVVGKADQAPSLFSDGAQTSVFKNVDFTAGLLAGTVMFSSSTRSSGASLTFSNSRLTTLGDDMPALWFGNLIASATLHATELNTTSGILVIANASQITQSFDHFVGWEENASIQPAQVTVSVTESSLKGDIVAYNSSSISWNLAEYSSWTGAASFGRGTAYLGVALDATSTWTLTRNVYLQNFTNADTTNGNIQSQGYNIYYNASSSSNAWLKATNTSLPGGGRLQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQQ2</accession>
    <name>A0A317VQQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_538550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463849.1">
        <property type="nucleotide sequence ID" value="XM_025612515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQQ2"/>
    <dbReference type="STRING" id="1450535.A0A317VQQ2"/>
    <dbReference type="GeneID" id="37114658"/>
    <dbReference type="OrthoDB" id="435022at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42871:SF1">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY75222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="458" mass="51200" checksum="6B9D24018F270B53" modified="2018-10-10" version="1">MPDIASNGARNGTSAHAEEKPESPVLHVVDSRTGKYHSIPIVRNAINASEFKKLKTAEDPEHPEDQNEQGIRVFDPGYSNTAVSESKVTYIDGLKGQIQYRGYRIEDIVGKKKFIDTAHLLIWGEWPTPEQAQTLHEKLSSVPVINESVFKVIQAFPPNSSIIGMMIAALSAVQSSQMDRIPAHAAKNLYLGLPKAVDDEIIRLMGTLSMITAAVYCHHTGRDFTPPRPELSYIENFLLMMGHVDSTTGLPNPQYVDRIERLWVLIADHEMTCSTAAFLQTASSLPDVFSCMISALSALYGPLHGGAIEVAYKNFEEIGTVENVAAKIERVKAGKERLYGYGHRIYRVTDPRFTFISQILDELKDEIARNPILKVAFEVDRVASEDEYFVSRRLRPNADLFAALTYSAMGFPTEFILPLSLLSRTQGFMAHWKEAMSGSARIWRPGQIYTGHLNREME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRZ6</accession>
    <name>A0A317VRZ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrion biogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_498863</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MDM31/MDM32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464162.1">
        <property type="nucleotide sequence ID" value="XM_025609358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRZ6"/>
    <dbReference type="STRING" id="1450535.A0A317VRZ6"/>
    <dbReference type="GeneID" id="37111501"/>
    <dbReference type="OrthoDB" id="17678at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000001">
        <property type="term" value="P:mitochondrion inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012571">
        <property type="entry name" value="Mdm31/Mdm32"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31068:SF0">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08118">
        <property type="entry name" value="MDM31_MDM32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY76349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="719" mass="81026" checksum="9AA14CAD2972D3AD" modified="2018-10-10" version="1">MSGNLGRRLYTTFWGTTESLLGHRLQARRVSSLPGTPNTKIPALRFLNIRTVKGFNSFSQETSRVTRRSTSGGFLVLGAFSIHNTRIACAIPLENTIPHKVSTIDRNSVGKVSWRVLKRGFHTGQDDRGKTELRKDTLDLHDRRHAPDHLTKNTGTAVHNNKDQGPDQQLHEVYPKSQSNRHLIGRLPHMPQLHRPTKEELLAAATGFWSRLKVRFKWFSIRSARPFNLDEITALFSWVLLGHVVWVVLGTTTFFSLLIIAINTVFAQETLAGWIGNYLTKSSGVKVVFESAIVPKWGDGVITFKNVFVSRRPGQGTGHVSKGSSKTAAAVAAAAARGDQSTPEMPDQRYLSDEEDTNYTQFDVSIETVNVTLSFTKWINGKGLLRDVEVRGIRGVVDRRYVHWSDDDLDPKSYRHEHNPGDFEIDSFKMSDVLVTVYQPDNFRPFPVSIFSCDLPQLRKQWLFYDFMSANMMSGSFDNSLFTIHPRQTHSFTGAQLDNGAEDDGKPSPWKKHNRIRVDGLNIDHLNRGVQGPFSWIHEGTVDIVADIMFPAENDESLAKVMADFYDRLEATVSSTRDLDSTPSKVSMSDEAASEDDRRFLVTDLRLHLNNARAIVPLFTRDLSYINNALIRPIVAYINSRRTFIPVNCRLVKRVGDFDGSWTTFDSGLMDDLSAAVYDAFARDVVDEQARKRRFKKVGFWSLQLAAQAIFMGMAGNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTU5</accession>
    <name>A0A317VTU5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_559288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464260.1">
        <property type="nucleotide sequence ID" value="XM_025614056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTU5"/>
    <dbReference type="STRING" id="1450535.A0A317VTU5"/>
    <dbReference type="GeneID" id="37116199"/>
    <dbReference type="OrthoDB" id="4227542at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37014:SF1">
        <property type="entry name" value="EXPRESSION LETHALITY PROTEIN HEL10, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="202" mass="20772" checksum="D17CFF0BBC520658" modified="2018-10-10" version="1">MSGYDGYNNQGYYGQGGHQQGGYSQGGYGQGGYGQGQGGYPQQGYGQQGGYDQYNQHGGQGGGSANDYYGGSGQQSQYGEGQYGQQQHQGGQQQYGQDQRGEYNQGAPGGAQEGERGLGGAIAGGLAGGFAGHKADHGFLGTIGGAIMGSIAEDAIKKHRHKDEQQQDYQSSYGGYPPQGGAPPSHGGSGGMMDQLGGFFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTZ0</accession>
    <name>A0A317VTZ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_538299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464235.1">
        <property type="nucleotide sequence ID" value="XM_025612462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTZ0"/>
    <dbReference type="STRING" id="1450535.A0A317VTZ0"/>
    <dbReference type="GeneID" id="37114605"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="193"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY76422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="595" mass="65190" checksum="7B331EFB4F2644A4" modified="2018-10-10" version="1">MRRAAFQALRTARRVPAWKVIGRKPCAVSFSSSRSLGLRPSSSGKHPSYLPASLHSSMHLRNFSLAVISTVVASGAWYAYQGNAGQALNATSSQLRSYATVHAEAPAESTRRALLVDNDQFFTAPLTGDQPLSKHTDDSDRRVLEMLTPEQATQKLRKNEESYLVNRGKGVVRYDIVQVPSNSPIEDDHAEKIIEVPSSLAAANEGEAKCDWMFWAVFDGHSGWTTSAKLRNVLISYVARELNSTYKAAAADPSLLTPSSGAVDAAIKQGFTRLDDEIVHSSVEKVLKSNSRRVAAEMLAPALSGSCALLAFYDSQSKDLKVAVAGDSRAVLGRRSANGKWSATPLSEDQTGGTPSEMKRLREEHPGEPNVVRNGRILGQLEPSRSFGDAFYKWSKETQDKIKRQFFGRTPHPLLKTPPYVTAEPIITTTKMDPGSGDFLVLATDGLWEMLSNEEVVGLVGQWVEQQRVGTGASNKTWLKSLFGFGEKELPVEARKATDSEGQRRPIRQQQYDIAGVASRFTVEDNNAATHLVRNAMGGKDKEMVSALLTLPSPYSRRYRDDVTVEVIFFGEGPDTRTVTVNEEASASENVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUE3</accession>
    <name>A0A317VUE3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear localization protein Npl6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_204745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464281.1">
        <property type="nucleotide sequence ID" value="XM_025606111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUE3"/>
    <dbReference type="STRING" id="1450535.A0A317VUE3"/>
    <dbReference type="GeneID" id="37108254"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY76468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="63113" checksum="C25EB9FE52D63B4B" modified="2018-10-10" version="1">MARKLRAAAQAAAQSMRNAAPPLPEASDEEMIEAPPSRGSSPPMEDPGDVSDKDLEVDPQPEPSLDDDTAATPAQDSNTPSHGDSPTRTGGRMSAIPRKRRIGRPPKNRPPDWDAPDEGGAQTPIHVTTPVKRRRGRPAASGGRWARNRGPSHVTQVPIDKEGNMMDVIDDEVALPDDPEGETKVDKNGNLQGDREYRVRVFTILNRGDRKYMLSTEPARCIGFRDSYLFFQKHKLLYKIIIDDEAKRDLIEREIIPHSYKGRAIGVVTARSVFREFGAKIIVGGKKVVDDYNVQAARERGDVEGETAVPEDKLPPPGEPYNKNQYVAWHGASSVYHTSAPSVPLPTGKAVDSKKRKVTVTGDNWMLEHAREASNFNSLISLARRENLEGQYDIHTNVVQYPKIMQPTHARWERLPPPDPRVASKLAKGLSTLSLTNGTDEEESAAVSSEANEAGDGQTESETTDASIFSTVPVALSRRFAIHDIHYESSPYSNLGVPGPDGDVHDLGSNGLVSVANSMNPEFTSPEVLEELPLECKEALIEAAAREWEWKSKWSREASDGARATSLKSYAWFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUU6</accession>
    <name>A0A317VUU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative ribosomal small subunit assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_498300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464658.1">
        <property type="nucleotide sequence ID" value="XM_025609345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUU6"/>
    <dbReference type="STRING" id="1450535.A0A317VUU6"/>
    <dbReference type="GeneID" id="37111488"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12293">
        <property type="entry name" value="dRRM_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="186"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY78146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="303" mass="34745" checksum="CB96598C20CD839F" modified="2018-10-10" version="1">MKKDFEIAGFLILPLRFPSTPAYAKPATHYLYLRAHEPRIPDADTPRSMFVVNIPADTTEAHLRHLFGMQLSAGRVERVEFEALQSTKKSAAPQANIAMSKKRKRVTADELQAQLDDVELPSTWDRRLQKSGARAVVVFADKPSMEASLKAARKAAKKETKIVWGEGVEDRLPSLGLQRYLNHEQLRYPDRAELLRTVNDYMTVFSQVAEARRREEARKAQEPDEDGFITVTSGPKLAAAAHEDEARELIEKQKQKSQGLEDFYRFQSREKRKEKQNQLLKKFDDDRRKLADMKKRKGKIAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW35</accession>
    <name>A0A317VW35_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cellulase</fullName>
            <ecNumber evidence="4">3.2.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Carboxymethylcellulase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cellulase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_603491</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464832.1">
        <property type="nucleotide sequence ID" value="XM_025616440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW35"/>
    <dbReference type="STRING" id="1450535.A0A317VW35"/>
    <dbReference type="GeneID" id="37118583"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000078">
        <property type="entry name" value="Endo-beta-1,4-glucanase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF6">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016264125" description="cellulase" evidence="17">
        <location>
            <begin position="18"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="35"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY78523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="328" mass="36334" checksum="4756A5CFE2A61C67" modified="2018-10-10" version="1">MKLHTLLLAAAAGSALAAPQHKKRASVFEWFGSNESGAEFGTNIPGVWGTDYIFPDPSTIATLIDDGMTIFRIQFMMERLVPDSMTGSYDEEYLTNLTTVVNAVTDAGVHAIVDPHNYGRYNGEIITSTSDFQTFWENLAGQYKDNDLVIFDTNNEYNTMEQDLVLELNQAAIDGIRAAGATSQYIFVEGNSWTGAWTWVDVNDNMKNLTDPEDKIVYEMHQYLDSDGSGTSETCVSETIGVERVTDATQWLKDNNKIGILGEYAGGSNDVCRTAVSGMLEYMANNTDVWKGAVWWAAGPWWGDYIFSMEPPDGTAYTGMLDILEPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW47</accession>
    <name>A0A317VW47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_627212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464147.1">
        <property type="nucleotide sequence ID" value="XM_025617399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW47"/>
    <dbReference type="GeneID" id="37119542"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="227" mass="24919" checksum="0B6F387E36BD97D0" modified="2018-10-10" version="1">MPSEKRKRTLNPSSYSPLYTSCHETHAPATITHYEQSQTSITTNIQIFSSSSSSFSTSHPSRTITSGFNTQFSYNMTVSSQSFDVNTSSGFVPAAMDFERAGLDFISAAERFERAGLDFVSAAMDFERAGPVVASATEDWRQGAVEFAYQAEAFRVDAEAFASESVSASASAWVSSSDVGGGGGCLGVGKWERVRRGGRRDAKREREEEEVVVTEEREEKRRKIQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWP4</accession>
    <name>A0A317VWP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_577647</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464515.1">
        <property type="nucleotide sequence ID" value="XM_025615183.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VWP4"/>
    <dbReference type="GeneID" id="37117326"/>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF26">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="45"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="279"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="671"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="783"/>
            <end position="1318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY77328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1354" mass="146785" checksum="C8E413BECDCC8D5D" modified="2018-10-10" version="1">MDAMVSGGPADLVHKKLPPAAPDKIARRIRSTTFTTMEPSTGKIKIAIDRGGTFTDVWACLPGHPEIVLKLLSVDPSNYSDAPIEGIRRVLSIYYGKEIPRGIPLPKGDIEFIRMGTTVATNALLERKGTRHAFLVTKGFRDLLDIGYQCRPRLFDLDIVKPAVLYDEVREIDARVTIEGFDEDVDGIFKCDKEIPGVLVRGTSGDMVRILKPLDEEQVRDTLRDLRRSGVDTLAVCFAHSHVFPDHESRVYQMAMKEGFIHISLSSTVAANMIKMVPRGSSASAEAYLTPEIKKYLTGFMQGFEDSNLDGVRCDFMRSDGGLVSHDHFSGLKGILSGPAGGVVGYARTTYNGITRKPLVGFDMGGTSTDVSRYGGHLEHIFESTTAGVTIQSPQLDINTVAAGGGSILTWKNGLFTVGPESASSHPGPACYRKGGPLTVTDANLFLGRLLPEHFPKIFGKAENEPLDSDIVRGKFDELTATINSDTGNSMSPREVACGFLDVANEAMCRPIRALTEGKGYDIASHNLSVFGGAGGQHACDVARKLGISTIIIHKYSSILSAYGMALADVVQEAQGPVNEIFGDESRSRLDERLLLLQGKVCDQLIDQGISEDDMIYQRYLNMRYQGTETAIMVLEPPDRDFKEEFKQMHLREFAFLFPDDRPILVDDVRVRGIGSSGDAEKSDGRIVEEELETSSFTAATWRAAEHMTRVYFRRTGTCRAPVFLLHKLAPRTVIAGPAIIIDQTQTLVVAPGAEAKVLSNHVVLHIRPTSPGGFFGDSKSVDNIQLSVFGQRFMSIAEQMGRALQKTAVSLNIKERLDFSCALFGPDGGLVANAPHVPVHLGSMSYAVRYQHELHKGKLVPGDVLVANHPEAGGTHLPDITVVTPVFNQTGTEIAFYVASRGHHTDIGGLGGTSMPPNSTDLWQEGAAIRSFKLIHAEKFDEEGITQILLRPGGYPGCTGSRHVSDNISDLKAQVAANHKGTALVQALIEEYSLPVVQLYMKAIQSNAEWAVREYLRSVLRQVGPRLLSEDQMDNGSLIKLAITISPDGSAKFDFTGTGCELLSNINAPPAITHSAIIYTIRLLIGTDIPLNQGCLAPIEVILPKGTFLNPSSGPAVCAGNTQTSQRIVDVILKAFRAAAASHGCMNCLGFFGEGGTDAEGKKLTGYAYAFGETICGGSGGTPARAGASGVHTHMTNTRITDPESLEKRYPVILREFAIRHGTGGKGMHRGGDGVVRDIECRAPLSFSVITERRSVAPYGMNGGEPGERGANYWVRRVKSEKGEQWRWINMGAKNMVRMEAGDRCVIHTPGGGGWGKVDDMDERMNGFTGYSMQYPRASGSVATHIMAQESSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VX19</accession>
    <name>A0A317VX19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein FYV10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein fyv10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_472427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464651.1">
        <property type="nucleotide sequence ID" value="XM_025608431.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VX19"/>
    <dbReference type="GeneID" id="37110574"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="6">
        <location>
            <begin position="223"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="7">
        <location>
            <begin position="501"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="22"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1018"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1348"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1399"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="789"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="986"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1037"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1103"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1138"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1161"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1348"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY78139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1471" mass="161447" checksum="0DFFBEB7CBCA276F" modified="2018-10-10" version="1">MTDASFPPSGGAAAAARAALLTNTSTTSTTSTSSSSSSTYYYSNPPSFSTIPRRSSYASVLSGTAALSPSPSTSIHHNVYNSPFSHLTPASFYSTASYPPPPFAPDARLLRPSAAVDAEMQMNSPWRPSPGDSLPPYSRKFANLARFDPFSHTPGHLADSATPYFTPSYLRNSRYVSRLDAARRAKIAAHRDGAIPSTTSNPISTTSSQASLPRIAPSHRGMTYDIIEREPPGDDDHLLPLPSRWNDDDKYSGLELTNGGLEVRYNGPVNKHDHEAAAVRADNPMPPQCGIYYFEITIISKPKEGMIGIGFSSKKASVERLPGWEQESWAYHGDDGKSFFGESQGQGRQYGPTFGANDTVGCGVNFSTGCAFFTKNGGFLGNAFRELRNLKVYPSVGMKKQSPVHLAVNFGQQPFMFDIDDMVKREKSLIHTEIGLTSTANLQPPLDESALLQELVAQFLAHDGYVETARAFAEEVAAESSALENGRQAPLKKYEVEEDVEAINRQKIRAAILEGDIDKALKYTNAYYANVLQTYPQIHFKLRCRKFLEMMRRCNEPTATKRGKSVNGLSDNSAVFDQEMELDEQVQEGDVYEADGMDMEEPETTARSNELLTEAVQYGQQLFLDYPPEERGGDRKMLDDIFSLVAYPDARRSVHGHYLDPAGRIAVAEELNSAILGMAVSLGKSSSAALERLYQQTEVLVNEISEEGGAGAFINVPHHRPPAASCLPCIPSHSASSDTDSPLALRCCCGRDDCAFLHHNHVALEGLEKDLATAARLGQALLHRHESYMAEAEEDRHRLLVSIENLEREKREVQAENARIIEENRGLLEQLEGLNKAVTDSDSHSKSLAARLESTEAELRKLTLSAARAADLEAQLAQMEVEQSKLQESLQSAQEDSKSAVQRWKQAECTLRDLHDQVDRIEKEAREERDRHAELVQRMERRRTVERELDGAAGRLKGAAAAHELGRNRGGATVVSRFVRDILQDNANLQMGIMELREMLESSNQEVENLRDQILSHQPLASEGQEARPATTLSQELESKESRRVSQELHIHHHYHSPTASAAPKKERGSLFRRSKKRRSLGSAAVLHSASGTPLARKANHRSQSSASSASTILSQTSVSIPPTAPHRWSIQSPVSDSMASSPQSAYQPSSIFDRVDRGFDSSQPTSPDSTVFTSPLRSGRFRKAQVDAAYRALDGDGLAAGSDDDMVHDYFQRRSSAEYVGRAAMQSVIPEEREDARSMHYAESQRAVSPTVPDGVFSSPYRAPRRSASHESLFSVAGMDIHTPSRRPSRLSDLHSGAIPVRIPRRIMSSSADLFPTPPVISTSIVTADREPAMLSDQCPQTLLASVAGSRSQTPIENDPESSTASRKLSLGRRVGGWVRGHWGTAPISSNEHIAETPTMASDTPAPRPSSAGSRKSRHRPELAPLRFRYPGVNQKGPIMGFRPTSRVPVSIHAEQVDEGLLRESLADAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2M7</accession>
    <name>A0A317W2M7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_548597</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465069.1">
        <property type="nucleotide sequence ID" value="XM_025613409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2M7"/>
    <dbReference type="STRING" id="1450535.A0A317W2M7"/>
    <dbReference type="GeneID" id="37115552"/>
    <dbReference type="OrthoDB" id="10056816at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006363">
        <property type="term" value="P:termination of RNA polymerase I transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF14">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="12">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY79497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="121" mass="13097" checksum="1130C488582E32D3" modified="2018-10-10" version="1">MSAIGTLVFCTDCGSLLDGSIGDPTKILVCDVCGARNKDTVPQTIVSESKPSAFPSTLRAKRSAVQTLTAQDRNTEALAQYTCVKCGRKEMYFTTVQLRSADEGSTVFYRCVCGHKESMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2Q0</accession>
    <name>A0A317W2Q0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HTH araC/xylS-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_537033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465476.1">
        <property type="nucleotide sequence ID" value="XM_025612178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2Q0"/>
    <dbReference type="STRING" id="1450535.A0A317W2Q0"/>
    <dbReference type="GeneID" id="37114321"/>
    <dbReference type="OrthoDB" id="2447880at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="entry name" value="DNA Methylphosphotriester Repair Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00165">
        <property type="entry name" value="HTH_AraC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="Ada DNA repair protein, N-terminal domain (N-Ada 10)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="6">
        <location>
            <begin position="97"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY80874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="236" mass="26414" checksum="AD973CE8BF313F99" modified="2018-10-10" version="1">MQTQTPSTSTCSSMYQTPHSRWTALSHRAPATHSSFIYGVKSTKIYCRPTCPARLARRANIIFYDTADQAQRDGFRPCKRCKPDTAGFAGEREEVVTKVIALLRIQKNDRMMRRGVKELAKEVGVSTSYLCRVFKKTMGITIGSYMTEFEKEASGNETETEISIQPLERFMPGVVVAGTDLYTPPILANGPAVPIDESEGGLREGVGNLQDALDFNLDEWFWFDEFWNQGSTTTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2Z4</accession>
    <name>A0A317W2Z4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_496407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465475.1">
        <property type="nucleotide sequence ID" value="XM_025609290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2Z4"/>
    <dbReference type="STRING" id="1450535.A0A317W2Z4"/>
    <dbReference type="GeneID" id="37111433"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="171"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY80873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="327" mass="37228" checksum="379BD392C51355A4" modified="2018-10-10" version="1" fragment="single">MALSMLDYSHFTSGSWDKREKFAHDLLGSFERTGFAKIRAHPFSAQELEELFTWSHKFFDQPLNEKNEIPNEPGPRPMRGYTPWRVEEVGKLHHDPKIRKIIDSKEHFDQGPQYDTEFPNKWPTAPQLSGFQPFMEAFYRKCDNICLTLIEALEVAWGIEDGSLVARCVPSSTDLRLTHYPAIPVEEMHSERTSRIAPHTDFGPITLLFQDSTGGLEIEDRTNPVPNSFVPLPPTDISEMIVNVGDTLTRWTNGKITGGVHRVTTPETMKNENGLIIPSRMSMAYLFKAGRNVSVGPLPKFVSSAMPAQYPDMTALEFQRWRNSIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W378</accession>
    <name>A0A317W378_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_496606</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465565.1">
        <property type="nucleotide sequence ID" value="XM_025609299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W378"/>
    <dbReference type="STRING" id="1450535.A0A317W378"/>
    <dbReference type="GeneID" id="37111442"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000038">
        <property type="entry name" value="DEAH-box RNA helicase (Dhr1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="373"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="573"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY80963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1205" mass="134151" checksum="93DE17962B9DA6AB" modified="2018-10-10" version="1">MPKFVPRQRKQKHRQREATNVPVDTNVAELAPVSKSEKDAKRQQLKEELRAQHAQVSSKKQKRLDKYIENKLKKEENLELLKKLAQSKVDTSALQSSRELGKRKRQDERVPVSTAEDHDSRLDSDLSDDDSDDSLPPSKAIASGSRQDAPAQKPAEDPATGSGLKRPLQLGPDGFPVLKKRKQAPKKPEITITMPEVPWEGFGSGDEDQSGEDDEDSEKTSEDGSSDAESGSDEEDEEDEEDEDCSEDEEDEDEDEEEEEEEEEEEEEEEEENHKVGKPRQSAFKTWARQQINDAVGFKPATVPVVSEPMPFILEPKKPVRNTVYEEEPLPLELQVTKGDPNRKAFSVQVNRSEEIQNSRLGLPVVGEEQKIMEAIYNNSAIVIWGATGSGKTTQLPQFLFEAGYGNPDSPSPGIIGVTQPRRVAAVSMAKRVGDELGEFSEQVSYQIRFESTASSKTAIKFMTDGILIREIAEDFSLSKYSVIVIDEAHERSVNTDILIGMVSRIVDLRKAMREEDPSVKPLKLVVMSATLRISDFTQNPNLFRQGPPPLVQAEGRQYPVTVHFSRRTNRDYVEEAFRKVSRGHRKLPPGAMLVFLTGQNEIRQLSKRLKQAFKPTQRGEATQAKVQITANDAPLEAEDLEIGGADLSIAGNQEDDGSDYEITGLDEAEEDEDEFDLDEEAMSSSTRVHVLPLYSQLPTKEQLRVFEPPPEGSRLIVLATNVAETSLTIPGIKYVFDCGRAKEKQYDLATGVQKFQIEWISKASANQRAGRAGRTGPGHCYRLYSSAIYENEFAEYTDPEILRTPIEGVVLQMKSMGLHNVINFPFPTPPSRQGLAKAEKLLKNLGALTAEGKITPIGNRLSTYPLSPRFGKMLYVGHQHGCMPYIIALVSALAVGDLFVPQNQIDPVPAKDGDEAKGVYTNADRLEDTAREQRHKDYARAHRLFSKHDDTSDALKYLSAICAYGYASDGDSFCEQMFLRAKAFKEATQLRRQLTDIVRSNNPGLVQAYQARLPEPSEKQVKAIKQIVTAGFIDNVALRADLAPVPPEMHRTPKRAIDVPYFTLMQSREGPGMELDDKAVYVHPSSIIAQLSAKEMPQYIVYSHLQQSSPSVVSADQTPKIRMFPLAAPSGLQLSALAHGTPLIEYGKPIGKTDLIEGIPQRRSCWVIPSLVGEAGGSRWPLPAKKVIQRKDAKEGWVIEKFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4A7</accession>
    <name>A0A317W4A7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ser/Thr protein phosphatase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_602254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465457.1">
        <property type="nucleotide sequence ID" value="XM_025616417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4A7"/>
    <dbReference type="STRING" id="1450535.A0A317W4A7"/>
    <dbReference type="GeneID" id="37118560"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF22">
        <property type="entry name" value="ADL392WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016415099" description="Ser/Thr protein phosphatase family protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="3">
        <location>
            <begin position="417"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY80855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="74171" checksum="DCC2873C72A301AD" modified="2018-10-10" version="1">MGISLLLCAAATAIPALAQGAGRELERSPMRALQQPDGHNATNWPWRPLPWGEINFIHTTDSHGFLEGHLNEVDYGADWGDFVSFVERMRDKADQYNVDLLVVDTGDLVNGNGLSDITDPGGQVSNKLFRNVEYDLLTIGNNDLYINETTKQVQKDIASIYGDRYITTNVDVVLDGKNISVGHRYRYFTTKHGLRVLAFGMTVQDFHRPDFITVQNASTVWNKPWFKEAISKEADLYVLLGHADVDEPCQFAKPTKYNATENPMICMKDWLRQNKPDIPVQILGGHTHARKFKCYDGASSGLESGRYADTVGWLALGDVASDTWNGSKTISGVDMPTRTCSPPSATSREADSTKIVHLDRRYLDFNRKTFAYHSIGGNDWTVLDQLDTPLGRKTTDDITNVRNYLNLTTVLGCAPQSYYIWAENFDCPSNIYTMVKAALNATVISDRENIPEDSPRLILMGTGGIRYDLFKGPFSVGDAYTVSPYPDSFRFIPNVKYSIASQLLTKLNEKDPCPPKDSCIYKRPSSFPDPYSEPFNQQPLMDPEPSKLNPGHVTVDDFGNCTKAVDSPDCGDDTQHSSQIEYQCLPNTIQAEFNIGKTPPDTVNLVFVSDRETTILGLDIIKDAGYDKSDVDDYMDPSFTTRDFLQKYAQIAWNDNSTECGIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4Z3</accession>
    <name>A0A317W4Z3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_537252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465241.1">
        <property type="nucleotide sequence ID" value="XM_025612228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4Z3"/>
    <dbReference type="GeneID" id="37114371"/>
    <dbReference type="OrthoDB" id="3016366at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="161" mass="18325" checksum="4912D358741E50F1" modified="2018-10-10" version="1">MDSSALYIALFIRDDPPKPNDYHWALYHHRSDSGTKYHIRNEGNGWMAAHGPESGIGILKSFCLVGLFQIAKISSTMSAQETLDRVFRSHDEKLNGDGVFTCRTWVLRVLRDLQEKLGVLNGIELGLLEKEAMEWGNQYRFEASRNVQPRPVGESVYLARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W517</accession>
    <name>A0A317W517_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_547790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465571.1">
        <property type="nucleotide sequence ID" value="XM_025613352.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W517"/>
    <dbReference type="GeneID" id="37115495"/>
    <dbReference type="OrthoDB" id="2546325at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF11">
        <property type="entry name" value="NACHT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01490)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="562"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2267"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2268"/>
            <end position="2277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY81503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2291" mass="260593" checksum="90D460D3B702E3A3" modified="2018-10-10" version="1">MSMASNDVPRDDHPRDVSTTPAGVEHPDAGSSAHLLVYQAGHDAMHDSHSAPNDHHLHSDSYLPDSSPGNGRSMSPYHERTTSEDESSSAIIDEPSTPEVIRSISPIQYKDEREQLAASGSSLVTYSSQYEFHETVLDSRKAEVLSRVGYFESNPRHGHGSIGRKTVSPPFSPARDRSKGINSPIDNLNFSDAPGYEPERVKESDTAPPRRSPSWKPRPDAFPAGRLSSGGDRAFYNLESPSTGQARPFRPRRGARPATPPARIIPRHGGHGSHGSPGGLASPPEWTGTPPHGGGGRFNLARYVLGMKPRFATALPTGLPTKVTTLREVQRRMDDLRLKLMPHRASRTDWILHRADGLAEDIDAFMSALRPADPAVADCSNLVMASFLHLIQLISVSKRSKWANSVVLEQAFTVLDQMAVILYHFTQHLGVPTAETSHIAILALVEVINFNWDILQAVQNEPVSSASIAFRLRFRTHLKQLVELEERFSVQVWRVAIERSSMDSLRDTDGAKDRTAAHKTGIETIRKWLSNGATTDRPIKFHAFSATTDADTELPLKWLSDLTTRFWQSHKSMLFIIGEAGTGKSACVRSILDRSKSRYSRRAKVLYFSVDPSLEGCRTSTDLVKSLLLQLFEQTIGDAAFLQSFRDVYGNEGDEDERRLWSILQQQAASLSAKYSGEELLLVIDGLDKIKGDKTQVCVWLHEVVKQSLRHRCIFLSRPLFDGNYGADSLHFEIDSRVLEEDTRFLVRTRVQQIGFLKRNERAARFVGERALQRPVDSLLRAHLLVALIELQESYRESTLVLQSIPTALPDFIDFMILQVKFDDPQVKHLLSWLLVAERAMTLREIEIMIDPHFAVGSLGSNATQFFRKSCASLIDIRQGFVQFVHPLIKERLVRLGHESTISLSPGAAHRVVLWRCLEYIQHRLPDAGPSRLTLEESGSLGNQILARVAKDPLLEYSILHYIKHYEESQPDSISEFRKVYLDSPLLAQLEHHYWKLHTSDALEHKHLQALDFRKAVHGGRSVSVVQTLITLSMLSNASGRRAKAVTYLGEAWCLASRLPDQDKPLCRELAMEYSNLCISETTSGLQVGVDMLCEELYEFLWDLEQEMGTQLSERALSQVEILLQIYQHRNKREQMAGLQRQLYERATVTFGRSDIRTLDYANRFAEVLFTLNCHHEVGNLCEELLIEMRDEIEVWDHRHLRILFHLVESYDSQGQQLQAETELRSAWQTLYRATVDRTSPDARLAFIQVTLRLGKLLITSFNYLEASEIAIKLWAALEEDTFPMDETTRRELLALSDYYIQAGIYEPVIPVLVELRSIYPDGLSINTYVEAVRISILLSKCYRHHPHRGDGTEFLVELVEALLLMDIVNEHCIDVVAELVDHYKERRDWHGAAPICYKVLERVWPELCQWEDYDPTIPEVLTESGLRMGLVYARLVVSQSSKDEAAGVLRFVFTSFRDSDRVGDMYVFEAADLYSEVLRDAGHMSEAIDVLQSLHTQFPEPYGAHHDQYSQIAEKLVDLYQMTDIQNVSEDILLNIVESFGHGEGLCQSTCFNAVLVLIQLYEAKDRPSEMRTWYERLWGAMMLHRGAGDITDDQMFGVLQKYSSLLLLHNQHAEAIQITRELRTLVSRDSIWLTQVDYELALLLEGDQQYREAVDLYEGICQSDMEMSEDQHQIPPFVTEATERLSRLYAQHASLAGRAEEMLRRAWQTALRSRGCSDDHTVACFHRLMDFYGQESSRTGRAWAQMEEFIVQIMIEELNEERLYDWAWTFSKLYQQFGDVNTGLQLLHDLRAERAFLMYRTEVPVPRIGEARLLLVDRRSFILVNTLEALLMGRPQAPVLAEIIQEVLTESALYEVWANIKRVKSSLQTGLTVSSRLIFLLQERGRKYEAGALLQEAWAMFQLHTQQDLSQSGVVWAFFNDCLHELHKRQPTISLVTSLVNACIELKRTQYFAGCFTLAKWAHEYLTRDVWGSQTKEITRLGFRLVQAIRSDESASPITIPGDLQELTEELIIGLVYHGRRDWIDVTGLSLGEVNIVIQFLSDKNDIDCLEQIFQSLWNARILLDNWHLNTTVSIGLRLCEVKFARGQCSEAHDLIDDMLYNLHDVYDEWDELHPLIIRCENLRARFHNRQGQHSLALTVHHDLLAQAVDRHLSHGPEDSHEEQALTTSEAWNDIMLDQVRSLKATYELNEGWDLHGAEHYLNTLEEAFNLAAGSAAWEHWQTLEEPSTWQPVCPIPKASRGESDTTGLKAGDVHGLWVVPQDWTIPEDEAEESAPDPTVDYGDRSWQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5N3</accession>
    <name>A0A317W5N3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mso1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_152970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465533.1">
        <property type="nucleotide sequence ID" value="XM_025605815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5N3"/>
    <dbReference type="GeneID" id="37107958"/>
    <dbReference type="OrthoDB" id="2683368at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="238" mass="24101" checksum="DA4908F1A67801DE" modified="2018-10-10" version="1">MFSSFTSSSAISNLGTRLRRAIHLGDEADDPDHEDCSHISNVLRAYYTEKARPFPGWLPPDPKAPTPAPGRVIATTQIQAGGGGGAPATSAYGRGGGLGDLWGDSGSAMPPTSQTASLRRGRLAPGNSMGAPLSATASAPSGSIASPPSQSPVPSAHPTGARPLPSQRAGSYQTISGPVTGAGSPGLERATSAQERLRARLHGGRSPSPGQNPSSRPGSPYVGADPSARKPVGMPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6R0</accession>
    <name>A0A317W6R0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_625790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465713.1">
        <property type="nucleotide sequence ID" value="XM_025617308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6R0"/>
    <dbReference type="GeneID" id="37119451"/>
    <dbReference type="OrthoDB" id="4477787at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016297593" evidence="1">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="196" mass="21234" checksum="09FFC377707CC1D4" modified="2018-10-10" version="1">MHHHLPTLTLLLLTLHTTTSTSTSTSTTSITNPLIGPTCQTLPTVIGPNLDTAYDNYYKTICSHGCKPVVGGQYTTLISETILKPSVQTIATNLGIDASRIATFLSITDESMKAVEQHCSATADYCEDTEAFAEYAACAKGQIFTVITSHALDVAVLVSEEVCKKEVEYLGNAEGGFWESVLPGYVDDFWAVCEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W7F0</accession>
    <name>A0A317W7F0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_520322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465669.1">
        <property type="nucleotide sequence ID" value="XM_025610103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W7F0"/>
    <dbReference type="STRING" id="1450535.A0A317W7F0"/>
    <dbReference type="GeneID" id="37112246"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF11">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10770)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY81601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="309" mass="34385" checksum="13CBC76B6D8673FB" modified="2018-10-10" version="1">MSSNDNDLYVGCKAYNPGFSTSYGYIPFQAAGIAFCVLFGLSMVVHIIQFCWKRTWWCSVFSIGCMVEVLGWAGRLWAAECPYNSTAFMIQISTLIIAPTFFTAGIYVLLGRFIQLFGRQSSILSPKRYLWIFCTCDIVSLVIQAAGGGLASSESNEVNGDTSLGTNIMVAGIVFQLVSLTIFVICAVDFFRRSLRLGYLGSLIQGSLSYLLFAMVFSVVCIYIRSIYRTIELAQGWTGYLITHQIYFIVLDGIMMVMAVGIFNIFHPGWLLPSDMTFVLPKDRAIIDLGDPEAQQLHSSTEYTGYGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W8U1</accession>
    <name>A0A317W8U1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Class II aldolase/adducin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_147587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465730.1">
        <property type="nucleotide sequence ID" value="XM_025605774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W8U1"/>
    <dbReference type="STRING" id="1450535.A0A317W8U1"/>
    <dbReference type="GeneID" id="37107917"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY81662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="295" mass="32060" checksum="EB72D6DC92221C6B" modified="2018-10-10" version="1">MAPPIETETTISSPLTLQTRQSTQETAAETAKVKNAPGKFPRPPVFEDKYKEREYLKGRLAAAFRIFGKNGYDEGVAGHITLRDPVDPTTFWVNPFGVAFSQIKASDLIQVSHSGEIIDGGPVRLLNAAAFMIHSAIHAARPDVLCAAHSHSIHGRTFCTLGRPLDITTQDACMFYNDHVVYKQFNGIVLAEEEGKNIAQALGSKKAALLQNHGLLTVGKTIEETVFWFVSLEKCCYTQLMADAAAAGRGGQTVKVDEADAAFTYKSIGGSMAGYFSAKPMFDVIHEETGGKYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEL1</accession>
    <name>A0A317WEL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Taurine catabolism dioxygenase TauD, TfdA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_536355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466130.1">
        <property type="nucleotide sequence ID" value="XM_025612000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEL1"/>
    <dbReference type="STRING" id="1450535.A0A317WEL1"/>
    <dbReference type="GeneID" id="37114143"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000009">
        <property type="entry name" value="Putative Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="82"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY83662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="384" mass="43749" checksum="C39A83395E8722F2" modified="2018-10-10" version="1">MALTQTIPIEIFPDGLKTTGQHPPLAEHIHPFEKFPTEITGPTVWKPEDYRDNPEKWTHRFTEAEIDELSFAADEFLRKKIPMTGISKNNFPLPTLSIRLHSLRSDLLDGKGFILFKGFPVEKWGNHKSAIAYMGLGTYLGYFVSQNSRGHVLGHVKDLGEDPTQIDSVRIYRTNARQFFHADDSDIVGLLCIHRAREGGESDLVSSHHVYNVLAKERPDVLKTLTEPIWYFDRKGETSKGQEEYIKTSVVYLERGENARVYTKWDPYYVRSLTRFSDAGIIPPLSAAQVEALEVLEETCNRVKLHMILEVGDIQFLANSHVLHARTAYVDHAPPTPRRHLMRLWLATPENEGGWKLPFWDSNEKKRGGIQVDDQAPVAPLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHC3</accession>
    <name>A0A317WHC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Putative lipase ATG15</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Autophagy-related protein 15</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Putative lipase atg15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO94DRAFT_547245</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466587.1">
        <property type="nucleotide sequence ID" value="XM_025613322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHC3"/>
    <dbReference type="STRING" id="1450535.A0A317WHC3"/>
    <dbReference type="GeneID" id="37115465"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 23" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016344649" description="Putative lipase ATG15" evidence="21">
        <location>
            <begin position="32"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="22">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PWY84662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="568" mass="61955" checksum="6D84F059E6D43B5F" modified="2018-10-10" version="1">MESRARKRSRGNTRLSHLLWPVTLFPGLVAAYQPEPVYFGSRQSSPFLPPQIPLVDHPSLSGTHEFTLRHIFHRGTYQDPDLHRRLDITPDTHLRAASDDEVTFDTPLVASSHPLMIERLADRRLSVIEQHLMAARSGSVAALSPSDWVLDTLAGPNVTEKETVVALAMMTANDYIEEPGTGDWQDIRDRFNHSGSFGWKDDGLRGHVYADQTNNTVVISLKGTSPALFDGEGTTTNDKINDNLLFSCCCGQGGSYLWRQVCDCQTTLYNANLTCIIEAVQEENRYYRASIDLYSNITALYPDANVWLTGHSLGGAVASLLGLTFGVPVVTFEAVPEALPAARLGLLSPQSRKHTGAYHFGHTADPVYMGTCNGVSSVCTWGGYAMESACHTGQMCVYDTVEDKGWRVGLEKHRINYVIAKVLAGYDDVPACAPEEECYDCELWKFFRSNGSEITTTTEATSTSTTSTTSRTSTCKTPGWWGCLDKTTTTEATSTSTSISTTSTSTCKTPGWFGCKDPTTTSGITSARPTITTTEPPQTTSSCKHPGWFGCRDATTTAAPTAPPVVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHH2</accession>
    <name>A0A317WHH2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Vacuolar protein sorting-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_98233</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the retromer complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the VPS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466840.1">
        <property type="nucleotide sequence ID" value="XM_025617774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHH2"/>
    <dbReference type="STRING" id="1450535.A0A317WHH2"/>
    <dbReference type="GeneID" id="37119917"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07625">
        <property type="entry name" value="BAR_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000046">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000034">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014461">
        <property type="entry name" value="Retromer_complex_Vps17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011791">
        <property type="entry name" value="Vps17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="8">
        <location>
            <begin position="161"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Sorting nexin/Vps5-like C-terminal" evidence="9">
        <location>
            <begin position="295"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="494"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR011791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY85823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="595" mass="65496" checksum="C0DA9200030A21CD" modified="2018-10-10" version="1">MDYSALSHDPDHPAGTSPWASPRPTQTTFPASVTGDIPPAPLPPQDHSPYNSAAESQPTEGPESQENENDSRDLSERLQSAQLGEAGYAGEQPPYTTQQQPQYGQQPRSQLPARYQTGPRQNARQPAPVYKIQAKVTGLERTGKKDPILRFDVHTNIPKFRTTQYRDVRRTHGEFVKLADHLISANPETFVPAVPSPLTPAGAGTEEDEIRVKSSLQRWLNVVLSNDVLTHDDEVVLFVESDFGYSPVVRMKQPATGVRRKVLKQFAPPPDDTPELQNARPTVKMFYLGTMDTSHKVDRVVKARRGLGLAESDFGVKLGQMHVQETHPGLSNAYRKLGKIIQTVGDFHAVQATAEATTLGDPLSYHSSDAFIVKETLTNRHILLRELIQAQQATRSKRAAADRLKVSSSVRPDKVDEAINALDEAQSHEDYLAKRTQRVTSNLLSEKQRWFARTSSDMLASLREYTMRQIEAERRTLATLESVRPDIRAIDASGGLSRLGRESHPAARRPNLGSSQGPKGDAWSGIPRRSDSLGRSLSGSFVAPSPTEDDDEVNGQGNGKGRLRSASGVSSIVEEDDDDRLDARNAASRLATSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ72</accession>
    <name>A0A317WJ72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_535825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466708.1">
        <property type="nucleotide sequence ID" value="XM_025611874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ72"/>
    <dbReference type="STRING" id="1450535.A0A317WJ72"/>
    <dbReference type="GeneID" id="37114017"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="217"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY85691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="446" mass="50956" checksum="606A47882608D523" modified="2018-10-10" version="1">MVSRKSMSRPPPDAGLDVKPRNKIQRKMLHIKRKRAKDAARHAERHAFKKEEAKNPKLKADRLKRNIPLTIDRKRVWDDAGSDVEDGLGLSVDVERIKRRKQEEEDELNRPLDEDEKSSEGEEESDDDEDDDDVDSMLASSDEEDEGVDGDDDDDDDDDNNTKKSSGDTRGRRKSSLPSATERATSPSQSTKSTNLTAVPDTLAAKFPSLFNTEKPPSPKILITTSLNSTLHHEAELLTDLFPNSVYVRRSRHRFAHQFSIREISKFASNRNFTAVVILREDQKKPTGLDIVHLPTGPMFHFSMTNWVEGKRIPGHGNSTEHWPELILNNFRTPLGLLTAHLFRTLFPPQPDIEGRQVVTVLNSRDYLFFRRHRYVFREKRETEKAVVGADGKEMKGAEGIRAGMQELGPRFTLKLRRVDKGIQRASGQEWEWKGGMEKTRTKFQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKU7</accession>
    <name>A0A317WKU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Benzoate 4-monooxygenase cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_596299</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467322.1">
        <property type="nucleotide sequence ID" value="XM_025616248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKU7"/>
    <dbReference type="STRING" id="1450535.A0A317WKU7"/>
    <dbReference type="GeneID" id="37118391"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF160">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY87114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="502" mass="55761" checksum="3718FF29055DF6B2" modified="2018-10-10" version="1">MVFAMALPSGQMPEINPSNLSLPVMAVVLVPWILILLIKFVPKGPTIKGVPGSFLDLFCCGIGTKINFVAGRSAHYFNSLHVAYGNVVRFAPGQATTNTIKGLRNIYGAGSGKGSAFLKTGFYKGISRRNIFTASDPSYHASVRKLFSPSLSPGSMQAHANVILGCISRLHDVINGKLESTNTVSLNQMLYCHSVDTVSEVLLGKSLGCLKRGKPYFWTEQLSRIFFWATIRDQFAGSGVPTMIKLMLRYLIRKGVRSRAEQARMRLINEQLTASHNRRDIMVEVMERASNSDLPVAEIAENFSAIMLAGFHTTQNALCATIYFVLTHPEAHAKLIGELQSAFASPEDVSGDIAQNLPYLNAVITESLRLYPPVPLGGPRVSPGAYVDGTYIPAGTEICTSLFALHHNPEYFNEPYEFIPERWTEAESTDKKEAVQPFLVGSRSCIAKYFAKQMMQLTLASFFMEYEAEYVGPVKDWQRESRCYAFWEVPDLKLKLRKRQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL06</accession>
    <name>A0A317WL06_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">20S-pre-rRNA D-site endonuclease NOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_467002</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466982.1">
        <property type="nucleotide sequence ID" value="XM_025608189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL06"/>
    <dbReference type="STRING" id="1450535.A0A317WL06"/>
    <dbReference type="GeneID" id="37110332"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000026">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="11">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="10">
        <location>
            <begin position="262"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="366"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY86391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="411" mass="45491" checksum="78DF82576390A2CB" modified="2018-10-10" version="1">MADSAAPTKPVHTIVLDAGPILKNTPPLSTLLTQCEELLITPSVVSEIRDPAARQRVETLYLPFLKQRTPSPKSVAILSEFARKTGDRAVLSRTDLEVLALAYEVECERNGGDWRLRSVPGQKQVNGKPPVKEEKVEEKVEGAEVDAVVEDLKSASLEDKEQETGAQETEVQETPAEAETEEPTSQDADAAEEEDDADDSDGGWITPSNLKKRQARDEAGSTTAAPEPKVMQVATMTTDFACQNVLLQMNLNLLSTSTLQRIRHLKSFIKRCHACFLTTKDMNKQFCPRCGKDTLTRVSCTTHANGQFTMHLKKNMQWNNRGNVFSVPKPIHGSSNGKWKGGGGKGGWGTELILAEDQKEYVRATAEQNRRQRKEHDLMDEDYLPGILTGERSKNGRVRVGAGRNVNSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLD4</accession>
    <name>A0A317WLD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_624947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466845.1">
        <property type="nucleotide sequence ID" value="XM_025617252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLD4"/>
    <dbReference type="STRING" id="1450535.A0A317WLD4"/>
    <dbReference type="GeneID" id="37119395"/>
    <dbReference type="OrthoDB" id="4347796at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="187"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY85828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="616" mass="68725" checksum="0C987C5D0B3D3450" modified="2018-10-10" version="1">MATQSETESLISFELGAHQYLARPIESYGVLEALSDSSGLVTYLHVSKDKTLDANALEDWRASLLAKDDVFHVDFLQHIIIGGACSSEVHLTEDVQDLFQGWNTTKITYEPQLDIASGPYYIQKGILYSVWKVYEDCQLAFLQATWPSSQGDGTLFKTISAGSDYRGHGIAVPARSYSIKWPSISTQIEDDSDSVLRGMRVSVKDNVHINGTRTTLGNRAYLETYPAQEHNAEVVSRLIKAGAHIVGKNHLSCLAMMEHPTQSADFQAPFNPRGDGYLLTGGSSTGSAAAVAAYDWLDTSICSDTTGSVRTPALQTGVFGFRPSTGAVSGEGLVNAWPDMDTVAWVGRDLKMFPDVFRVLANSWATAKGGNFSSEDSIEILYPSDFLPGNSEQSRVTEDFLAQITSATGGSFRPISIHDDWRNTAPVEEKDLRQYLYNLTQHGWFYSAYKSFEQFRNDYIEKHGYSPFVTEVVRWYWALGKDVTGEDYPELRNRLAIFRNWFLEQYLQDRPRNTLIAMHIDTVRPKYRDEYPGANNPDVPGLRATYLSAILQAPELAIPIGQIDYYSRIIERLEKIPVAVCLMGAPGTDLELIEWTLQAMEKADRPTKVKTGKLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN19</accession>
    <name>A0A317WN19_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_534792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467582.1">
        <property type="nucleotide sequence ID" value="XM_025611625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN19"/>
    <dbReference type="STRING" id="1450535.A0A317WN19"/>
    <dbReference type="GeneID" id="37113768"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="475"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="539"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="680"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="457"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="737"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="789"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY87799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="817" mass="89564" checksum="C465FB8BFEDD496A" modified="2018-10-10" version="1">MSDESKPKGFPDISAKLSAIPKKSLFERQKAEAEAKRAREQAETAAVYEDFVKSFEDDSHGPDRHSGDGRLSRFPPKNPGFGGGPGKRHFTSSNPRMSGPGTLGPPPQSISRKRTHEGLQPLHRNRDTAQGILGFDNTAPSSAAAVSAFRASDDDDEGAGDAKEAERAAAKPTLYLASLPPGTSPSVLKSLIPSVLTVDNVKILRPLGQPITDRKSVAAIVTLANESAASDIDSTVSALQNRYLGWGYYLTISRHLSSAAIGSTIPVTVGLSSTCSLPFGAKSIAPDIPGRLNRAPPPGLHRGGFAPPSSYGPAHGRGPSTQVEVKAPSDLKQLKLIHKTMENLLNYGPEFEALLMSRPEVQREEKWAWLWNARSAGGVYYRWKIWEILTNNRPVANRRGRPQPSSTIFEGGASWAPPEAHIKFEYTTRMDEFVTDDDYDSSDEEMSDYEEERRNLGGAPPAEGSGASNEGLGYMNPLQKAKLTHLLARLPTTHAKLRKGDVARVTAFAIEHAGAGADEVVEMIVSNIINPFAYTGANPDREAEKGLTRREQAGDLANDNPADEGRLSTKETLDLSSAKLVGLYLVSDILSSSATSGVRHAWRYRQLFESSLKTHQVFEHLGRLEKDLQWGRLRAEKWKRSVGSLLHLWEGWCVFPQSSQEHFFQIFDKPPLTEAELREEREKAEAERAASAFSKNKSRWKTVDEDTSGKFDPGRAPDIDPQRMDVDQENVAPAGTEDFDGESMSDIDGEPMEDSDLEGPDEDPLEEEILEDDSGLKEQPEKPAEPSAQPEPQPEPQPPARKPRPRAEDMFADSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNH5</accession>
    <name>A0A317WNH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_84130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467079.1">
        <property type="nucleotide sequence ID" value="XM_025617702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNH5"/>
    <dbReference type="STRING" id="1450535.A0A317WNH5"/>
    <dbReference type="GeneID" id="37119845"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015101">
        <property type="term" value="F:organic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000046">
        <property type="entry name" value="Amino-acid permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF7">
        <property type="entry name" value="CHOLINE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY86488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="518" mass="56303" checksum="EEAA85AB5B5DAF6B" modified="2018-10-10" version="1">MSALDIEKKASVNHASSSENASGSDDADGLRLAEMGYTQDLQRNFSLLSLVGIAFCMSNSWFGISASLITGISSGGTVLIIYGLFWITFISCCVAASLSELASSMPNSGGQYFWANELAPKKYARFSSYVTGWFGYAGAIFASASVVLSLGSGVVGMWQLGHPSFVPQAWHTVVAYQLINFFCYLFNCWGKFLPAVAKATLYISLLSFLVILIVVPACANPHASGSFVFGHFANATGWKSDGIAFIVGLINPNWIFACLDSATHLAEEVPQPEKNIPIAIMTTVGLGFVTAWFYCVAMFFSITDLDALLNSATGVPILELYYQALRNRAGAIVLETLLVVTGMGCLIACHTWQSRLAWAFARDRGMPGHQWLSQVNKKLDVPIAAHTASCFIVAVLGLLYLGSSTAFNSMVTACISLLYISYSIPVICLLYRGRDNIKHGPFWLGKWGLFANIVTLAWTLFCLVMYSFPASMPVTTGNMNYVSAVYGVVVFIILCDWFVRGRRSFRGSLSCVEGENTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNM7</accession>
    <name>A0A317WNM7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell differentiation and development protein Fsr1/Pro11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_465550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467857.1">
        <property type="nucleotide sequence ID" value="XM_025608123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNM7"/>
    <dbReference type="STRING" id="1450535.A0A317WNM7"/>
    <dbReference type="GeneID" id="37110266"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="6">
        <location>
            <begin position="35"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="750"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="364"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="582"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="829" mass="90068" checksum="73F821FDEA921F31" modified="2018-10-10" version="1">MAWQSPSAMAGGGGYVGPGGDGSSNGGHPQGTEYTLQGVMRFLQTEWHRHERDRNAWEIERAEMKSRIGKLEGDVRTSKRLHESLGKHVRLLEAALKKEREKVKKLSNNEKVEDTRDPKDIARESINALKVQRPKSHTPNEADVNLENEHEFRQENEREKSRLYLSKCSQEVAYHVIPSSHPAPDLNDQDIQNHIYGNQQLSQQSLEEAYLQQQRQKQQHHHQQQQANDMMAREAALQNHQPVITHYSDNAALSRAQSQFGFPPATREAMERRALEPQQTPLTVIDNRKQALNNSLMDERAAHGEQAYDGYGAQSAGKDSKQQVEENAEDTDGWNFDEPADQAPQAEQMPPHRPDVDAFPNANFVGSKSPQRSGSLSHRRKSSGARRKSDGAIDLATAAKSEPTFKVRFALRGHLDVVRSVIFTGGGSPSEPEICTCSDDGTIKRWIIPATYGTFGASSSSDLDITSYFTHRGHVGAVTALAACSPSQNFSNGGRALGDGWVFSGGQDASVRVWERGRVDPKATLDGHTDAVWGLCVLPGTAGSVFGESSNHYGGPDRILLASGGADGRIIIWAVSAPPQLSSPQAGSRRAGGSRRANSISSGSNFPSSPQPSTATTTPFHYTMVRQIVRTESPSPTCISPLSLAGINFVVSYTDASILVYDTRTGEEIVGMASLETYDGTPSTGVNSVVATTVGFDGSAGLDPSRTMGEEEVVHGATGSSGVEGVIISGYEDRYIRFFDANSGQCTYTMLAHPSAIASLSLSPDGRELVSAGHDASLRFWNLEKRSCTQEITSHRLMRGEGVCSAVWSRDGRWIVSGGGDGVVKVFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WR17</accession>
    <name>A0A317WR17_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_54209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468251.1">
        <property type="nucleotide sequence ID" value="XM_025613073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WR17"/>
    <dbReference type="STRING" id="1450535.A0A317WR17"/>
    <dbReference type="GeneID" id="37115216"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY88889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="396" mass="42950" checksum="229F7E0C1FA7D78F" modified="2018-10-10" version="1">MSGKDMLSHDDFAVGWICTLPLEMTAAKAVLDHEYPRLPQPEHDHNTYVLGRVSGHNLVITCLPSGIYGTTAATAVVNQMLSTFRSLRFGLMVGIGEGVPSPTADVRLGDVVVSKPTAGLPGVIQYDYGKTVASGRFQQTGALNKPPLVLLSVLSSLEADRLAGGCGNDSHDKIMTDARIAVKDLTVFRYPGAEHDWLFHASYDHDPCFEFCAECDPDRQVRRQPRASPTPVVHYGNIASGNQIMKHGLTRDRIAQTAHGILCFEMEAAGIMDLLPCLVIRGICDYSDSHKNKEWQGFAALTAAAYAKELLAKIPVLRVEASTVIKAPGPGTSNLFEVRFDTIDIPRSVICVGREAELAMVSQSLRSGKSRGIVSLSGMGGIGKTQVSIEYTMRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVF9</accession>
    <name>A0A317WVF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Negative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468724.1">
        <property type="nucleotide sequence ID" value="XM_025611407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVF9"/>
    <dbReference type="GeneID" id="37113550"/>
    <dbReference type="OrthoDB" id="2101473at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007396">
        <property type="entry name" value="TR_PAI2-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35802:SF1">
        <property type="entry name" value="PROTEASE SYNTHASE AND SPORULATION PROTEIN PAI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04299">
        <property type="entry name" value="FMN_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010372">
        <property type="entry name" value="PaiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="248" mass="27473" checksum="CBDCAD62D979A0C0" modified="2018-10-10" version="1">MHIPARHAETDPTVLRQFIRDNPLGILTTATPDTPHPLLQVSHIPWVLGFEDEQEENANSSTTANSTKSPRLGRLRGHMTRQDPQAEALLFNLPCSSPAYLEQEVLIMFNGPAHHYITPKFYTQTKPATGKVVPTWNYSAVQVYGRARIYHDTQSENVARFLSTQLDDLGRLEGMGILDYGATLGSLAPWQGSDAPEEYIELFTKSLIGIEVEITSLSGRFKWSQDKPPGDRDGMIAGLQNLGSESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYV7</accession>
    <name>A0A317WYV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_564876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469271.1">
        <property type="nucleotide sequence ID" value="XM_025614456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYV7"/>
    <dbReference type="STRING" id="1450535.A0A317WYV7"/>
    <dbReference type="GeneID" id="37116599"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="326" mass="36362" checksum="5FBD174755871C3C" modified="2018-10-10" version="1">MGRSLVKTALSRDDLVAAVGRTFENSPEAMRKLEADHENCLGLLCDVRARDTVKRVIDRTIDRFGRIDIIANCSGYGVIGACEDQDEYDIRDQFETNFTGTLNMIQLSLPHFRERRSGRYLIFSSTSGALGVPGLGPYCASKYAVEGLMESMLYEVDNFNIKTTLVEPGHMRRDDIGDLLGSDSPPFLNTTTTANNNNNNDHQEHNLASPLPLYGHFLVKPPSDPYNTPTSPAAHAKRMLMWLGDKQPASAVKAAHLVWQLGHCSYPPLRLILGTYAVESIRDRLKCIIEEIEDWKYLSFPTGEQQGPSPARDKVSVREGDDMDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ13</accession>
    <name>A0A317WZ13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_584202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469321.1">
        <property type="nucleotide sequence ID" value="XM_025615609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ13"/>
    <dbReference type="GeneID" id="37117752"/>
    <dbReference type="OrthoDB" id="4385933at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="434" mass="50215" checksum="A08955298B59C9E3" modified="2018-10-10" version="1">MPEVGKDYLSRVLPNELLFWCTRYLDHLSYFKLKKTCTGLNKKLQGEYNTRLKKYALQTREYHLNCHQEPHLGSLPCLEGDCQIDPRNQRLGAMSHLRATILKNDMITFEKYLDAGLDPNMFIDGNWEPFAIHMRIKMFKLLLKRGADVTLIPYENSDTKRRMIDWVGDFSDKKLAEEWISLFMKYGASFTSGKVLEKLCEMESAAKQLWLAAKNGVDFSTPLEKILSLDAQRIIWDTFDEPAALHFATCWLKPIVIDIILRHQPEQRRHLDSAFNMAVRRNCSKTAVHLLRKGARLNVDLLEGALKVYPLHDPHRPDLLRCMAARVDLGNPEPIPQVQRYLELAQSGSPNYGVILPLLKKMSPKARLLCADSLDIETYRRDLEEAREYLSESTDIEELGSTETEESDLTLSWWTRNEKEITEILELMEEAIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ70</accession>
    <name>A0A317WZ70_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_533761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469371.1">
        <property type="nucleotide sequence ID" value="XM_025611392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ70"/>
    <dbReference type="STRING" id="1450535.A0A317WZ70"/>
    <dbReference type="GeneID" id="37113535"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016260804" evidence="2">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="90"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="356" mass="38791" checksum="A1FC8EF532E14AFD" modified="2018-10-10" version="1">MKLPTTLLLSTILHTMSTTAQNLSYGADNFYRSDTVTLQPITFKNQYQMTIAGNLFTPKNLTSTSAPSPAIVIGHPMGAVKEQSANLYATKLAEQGFITISLDLPFWGSSSGTPRNAVSPDLYAEAFSAAVDYLGTQSLVNRDRIGAIGICGSGSFVISAAKIDPRIKAIATASMYNMGAVNRNGLNYSQTLSERQSIIADAAQHRWIEIQNASLTEYTSGTPNQLTPNTSAVGREFYDFYRTSRGEFTPAGSTPELTTHPTLTSNLKFMNFYPFNDIESIAPRPLLFISGDRAHSREFSEDAFRRAAEPKELVWIPGAGHVDLYDRVELIPFERLTSFFRVNLGGVEGGNGTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZB5</accession>
    <name>A0A317WZB5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP cyclohydrolase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_623353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468985.1">
        <property type="nucleotide sequence ID" value="XM_025617147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZB5"/>
    <dbReference type="STRING" id="1450535.A0A317WZB5"/>
    <dbReference type="GeneID" id="37119290"/>
    <dbReference type="OrthoDB" id="57939at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022163">
        <property type="entry name" value="GTP_CH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005536">
        <property type="entry name" value="PRK07198.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47259:SF2">
        <property type="entry name" value="URACIL-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12471">
        <property type="entry name" value="GTP_CH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GTP cyclohydrolase N-terminal" evidence="6">
        <location>
            <begin position="17"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="5">
        <location>
            <begin position="249"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY90607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="437" mass="48658" checksum="40D47BDD7BD3E556" modified="2018-10-10" version="1">MTTTQQTSSPSEHYSNRIVLTTYPSQSVANPIPLTWGASSPATRGPVIVSRTKNTLSKRNAIGAHGGSYSIYTALAIASGDLEPDFKPNFLNTQPTFNFPAQPAWSDPKKIVSMDPYGHDIIKHYSSYLSSGIDVRPTIAVTRATMRVSEITEAITHSRIPIDGSIVLNKSGDVKVTKVAVEPVWYLPGVAERFGVEEKDLRRALFEHTGGSYPELITRPDMKVFLPPIGGLTVYIFGPPERVSDPEIKLALRIHDECNGSDVFQSDICTCRPYLTFGIEEAIKQAQGGGSGVVIYFRKEGRALGEVVKYLVYNSRKRGGDTADKYFQRTENIAGTKDMRFQALMPDILHWLGITKIDRMLSMSNMKHDAIVEQGIPIYERIPIPDDMIPEDSRVEIDAKIHSGYFTTGRQITEDDLKEVKGRGWESWEDVTVAEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZT0</accession>
    <name>A0A317WZT0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_461646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469622.1">
        <property type="nucleotide sequence ID" value="XM_025607943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZT0"/>
    <dbReference type="STRING" id="1450535.A0A317WZT0"/>
    <dbReference type="GeneID" id="37110086"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="289" mass="33298" checksum="6CCE5007571078BB" modified="2018-10-10" version="1">MTEQKSDVCIACGWTSADQKRCCYSSHVKLFYGAGNRGVWSIGSDMILKERPDEGPKAEVDTLRKLAAHKDIPVPKLVRDWVDRDGRYFVLMERMDGETLEKAWPSLSESQKLSIADQVVHVRNQLKKITSTSIQAVDQGPCYLSLLYLDFELRGPFHSDAELWDSLILSLRNKSFPEKVLENLKKRLPPCGPYVLTHCDLNLGNIMVKDGELVGILDWEYAAYYPIWYEYVAASVGFAEMDVEWKKLLRQRLDVYEDARNLWRDLYHLRDYPNLDKKGQEILANLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZY6</accession>
    <name>A0A317WZY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_584301</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468666.1">
        <property type="nucleotide sequence ID" value="XM_025615614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZY6"/>
    <dbReference type="STRING" id="1450535.A0A317WZY6"/>
    <dbReference type="GeneID" id="37117757"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="245"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY90288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="598" mass="67504" checksum="02CD2167EF4E0217" modified="2018-10-10" version="1">MSYRLTHIRRKLDPDYASGLEDQIMMLREEVRRLENLNAFVPILDEDNPLGQQQSHARSDDAAAIPPNMATAIEDVSALMWRLSIGSSGEESFIGPSGNFCFPIAYCDDPDVRVEKTTATSSPGLAPGMELLWSDQANMSSVIHHLLDRFSQLINPIHQFLDGETLDQIHGNNLSPGLRLVKTAVVAAGALFSDDANGKAFGDEAAAVVDAVALQLCRQSPSISTIQTLSIMCWRELGLEQHNMAWMYNSMCASLALHLGLPVSASEDIGLSSPEHDTLFRESRVRDVRLRSLWSSVFMDRIATSLLGRTCMLPWKRIKAHSFISSIGPSPSLDELAFDHQCRLWFIHDQYMDRIYSFDFSELSNTDKSRILLDARDQLYSFRRQLHPQVQLDRNSINPSMIYLHMSYHMSHILIHRPYLKGAAQSDMYKLCVWSMSSAASSIVRLLREYRKVAPLDQISPFAVHSVLTAAVTHLCNATSTHQTLRSQSIAWFRVCFDALRAMQQRWIKAKRGIRLLQELARRWQVMVALPLQHGFPPLSDPAWETLEEMPELELPPNAGYDGNETGIPVIFPDIFNQASMDPFDMAFYQENLFSEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X098</accession>
    <name>A0A317X098_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_397592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469319.1">
        <property type="nucleotide sequence ID" value="XM_025607375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X098"/>
    <dbReference type="STRING" id="1450535.A0A317X098"/>
    <dbReference type="GeneID" id="37109518"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="118" mass="13721" checksum="D2423DB6C9D2F64F" modified="2018-10-10" version="1">MQRTQHPACIMTSQSHFEIFNLAHSARDSQPTFPDFLCLPIELRPNLIRVHLSTRTEGSSIQEARTIKERYCATVNGHQVLSKLWQVNREARKVALRFYRIHLPCMLRWGVPHDNATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1B6</accession>
    <name>A0A317X1B6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_555515</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468708.1">
        <property type="nucleotide sequence ID" value="XM_025613804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1B6"/>
    <dbReference type="STRING" id="1450535.A0A317X1B6"/>
    <dbReference type="GeneID" id="37115947"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="564"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="600"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY90330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="621" mass="68041" checksum="EC9F0BBDF22B3D3C" modified="2018-10-10" version="1">MCRSPNPVPPGRGLIRLLILAASADETRIADAIIPGEVSNEVIHVHSKSDPEKNAYEVDARALENEEYPIPTEEEVSTLRKVPANLPLVAYSLCLVEFAERASYYGAQTVFSNFIEFPLPKGGNGAGAPPRGSQETAGALGMGLQASDGLVLLFQFLAYVIPIFGGWWADVHIGRYKAICVGVAICGIAHIIQIIGAIPSVLQAGTGHAAPPFIIGLLMLAFGAGVFKPNIAPTVLDQHRHHKPYTKVLKTGEKVIVDPELTATRTMLIFYGIINVGAFYMLATTYAEKYVGYWLAFLLAGIIYFILPVVLAAVYKKTYKTPPKGNSDLAKAIKITVTALRENKWQVWRKNFFDAAKPSVLAAKGIQVEWTDKLVDDVRRTLVATEIFFYFPIYNLNDGGIGSVSTNQGASMVTNGAPNDLLSNFNALTIIVAVPIVDFVIYPLLNRYNIPFKRISRITFGFILAALSGMCGALIQWRVYKSSPCGYFASTCAEVSPISIWWQLPNTILGALSEIFCNVTAYELAYARSPESMRGLVMAIFLFMTALSSALGEILLPVTEDPDLIWIWGAPAVALGLQTILFWFRFKHLNNDEFMTDDADYDDTNSEAPIQASEDVKTSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1G6</accession>
    <name>A0A317X1G6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_618237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469170.1">
        <property type="nucleotide sequence ID" value="XM_025616843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1G6"/>
    <dbReference type="STRING" id="1450535.A0A317X1G6"/>
    <dbReference type="GeneID" id="37118986"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39469:SF1">
        <property type="entry name" value="DUF4203 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016351494" description="TM7S3/TM198-like domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="TM7S3/TM198-like" evidence="8">
        <location>
            <begin position="110"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="326"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="484"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="830"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="943"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="989"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="500"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="749"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="874"/>
            <end position="897"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1099" mass="118635" checksum="1D692ACD1A52A020" modified="2018-10-10" version="1">MRLFPLFALVACLVPGWSVSAEILAPERHGLGGLVVREATPSTATATETFSDTTAASVTNHAAAKVNSTTTSNATAPASTTTAALNGKNSTDPDALPIQPTVTPALGIGGFLLLVTGAVLALIGIRNLRVQVFLSTAFLTGLGVTVLIVYVMSPPVRVAIQGAYLVAIFFTGITFGALAIVFKELTEGLGCLLGGFCSSMWLLSLKPGGLFTGTNAKSGFIGAISVAFYAMSFSHHTRPYGLIVSTGISGGTAVALGIDCFSRAGLKEFWLYIWGLNDNIFPLGTDTYPITRNIRVELAATVIIAILGAVSQLRLWKVVRERRRREKEKRDDEQRKKEESEAELGRRLEEDNIQERKDWEAKYGDAKPTSSKSEFADDTKCHADEVDAMEKGDAYDSKSMANSSDCSYRCSDCREREANEDGVSDATGATEGAHDWEQAGTAKETSDKIHEESGSLPIKVFDGAAAAQIKDDKSSDMTAVIGSDTATIRSKRASGASCMPQGSRSNDLPLSQSQEALVSVDDGTSSVHSTIDEGVDPDSDGLIAQGESRGCTKDIPESDEHPPVGDAERQQAEPEQGSHDKQTHMLNNVNEAIIQKGKETQPTAVSTTEPKKVEDKEGFDPDSHSIASEVALTVVNHGTPGQNSDVIAGQEKSDGLSSPPDEPPIEPVGEEGKPSACVPKTGDTGEQDSEDHNCDQPQTGEPEKPNTAPDGQNQRSHGESISPLASSQKENENKREASRGKCKSPEPQPRIEPEPTKEEPPKLNEETVKDLPKRTSRVVQSYRTNEWAKHLADAEAPELEPIKPIEEEQPESSPEVEEAAVPVNVLELLQTPLNAQPPPAVEPRVRDPPSRRGSHRISSGSQLHLCSHTDQLKKASQSPLPTAQPRFSNAYSMSTLFGNPAAIEQPQEDAEAAKPQWKGPAPLIAVREDMMRNRLSSYSLSIDPFSRNNPGQPPTEGLRRSSTCRIRDEADDMPLSQRRAMLYQQTVPSPLPAHAPYSTSRRSQGHGPSPTNTPAAMAAWRESVQEDLKDKRNPLAKQNNSMVPPGQDRNPPPYSQSQRHSIHIGNAIAEGMQRGDMSELHREAMRRMQAKANKNAREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1Y9</accession>
    <name>A0A317X1Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_30290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468938.1">
        <property type="nucleotide sequence ID" value="XM_025606762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1Y9"/>
    <dbReference type="GeneID" id="37108905"/>
    <dbReference type="OrthoDB" id="4510378at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY90560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="279" mass="32201" checksum="8C3AEC5C87303819" modified="2018-10-10" version="1">MRPNRRLRLSSCLRDVKRRKNELGGILQHLDRTEKTFLAGEQLRKQGIELSDLDFHSGKLYSPSAVPYFMPILDDSREFLKSTRDLVQDGDIQSRCFSKAAGDQEGGWPEDPATIMRRHLFYIQGKSDWHVIQRGKSKRGRGCDRYFEMRIAIESHSKLQSHQMLMTVMNPCASQRTMSAHEDEFTADCRPSVSELTMLVSWMLGGMIHQEEEILAMANKPRLPTLRIHVIFPTLVFSFVRPARVRILYGYFEGTLKVQATKLQDINVSNYTEMMESLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X352</accession>
    <name>A0A317X352_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_554579</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469747.1">
        <property type="nucleotide sequence ID" value="XM_025613728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X352"/>
    <dbReference type="GeneID" id="37115871"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY92986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="527" mass="56124" checksum="01A620C807712E29" modified="2018-10-10" version="1">MSSQPTQPSPGKDNTVQTECLADPVHIPSSQWRLAIITVSLCCGTFLVALDTTILSVAVPSISTSFQAFGDVGWYGSAYLLTLFNAKTTYLVAAVLLEVGSVICAAGPSSAAFICGRAITGVGAAGLYQGALSIFGLTVSLEQRPMYLAIVLSVFGITACLGPPLGGILTQHATWRWCFWINLPIGAVAFVLIVCFLKLQPPRARMTQPILMRIRTLDIPGIVLIIGSVCCLILAMQVIGLFIGAALLLGAFFLSQWYQGERSTIPLRVARQRSVLMGVCFSFFLEISVYVTLYYIPFYFQSAQLVSPTVSGVRGIPLGVSQIVAVVLTGAVVSMTGHYVPFMVLGQIVSIVGTVCLTRLEVGTPTAQWATFLVIAGVGHGMGLQMPFTATQVVLSEDDLSIGNAITLFFSQLGAAVAIAPGENIFHTSIAHHVQASHLSVSAATVIAAGPTKLQSLTTDATTLHKLQDAYAYGTRMIMYFSLAASCAAVPFALGMEWRNVKKEAEKRSAKKAAEEAIIDKEEPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X379</accession>
    <name>A0A317X379_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_584055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469166.1">
        <property type="nucleotide sequence ID" value="XM_025615601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X379"/>
    <dbReference type="GeneID" id="37117744"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="150" mass="16282" checksum="01ECB54659C5430F" modified="2018-10-10" version="1">MLRIILMDSIQEWPAHEGPIMRVGVGNLVGMTQVTGCTVGVADHGYHTWPLASQLYGARNGLYTTTTTYICTEYESAIICCFGFVPIGAATSNPTALAPIMSWQSKAAGMFDLRHSGQVWNKPLPHHLIPNQSPLLTNAPRLGDVDIEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3G9</accession>
    <name>A0A317X3G9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_615957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469874.1">
        <property type="nucleotide sequence ID" value="XM_025616783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3G9"/>
    <dbReference type="STRING" id="1450535.A0A317X3G9"/>
    <dbReference type="GeneID" id="37118926"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.40:FF:000001">
        <property type="entry name" value="L-PSP family endoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00004">
        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="129" mass="13602" checksum="D6B4B69C2489C8ED" modified="2018-10-10" version="1">MSSRTAVTTNEAPKGGPLLSQAIISGGLVFTSGSLGIDHETGQFVTGGTYDRAVKAFRNLEAVLKAAGSGLEKAVKVTIFLSSMEYYSELNRAYADVFADVEPKPSRTCVSVAKLPLDAELEVEMVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X512</accession>
    <name>A0A317X512_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF953 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_533759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469368.1">
        <property type="nucleotide sequence ID" value="XM_025611391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X512"/>
    <dbReference type="STRING" id="1450535.A0A317X512"/>
    <dbReference type="GeneID" id="37113534"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="15"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY91640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="127" mass="14468" checksum="BC86AB0F5DFCDB70" modified="2018-10-10" version="1">MPFLTNFTLPSSAQHLEVSDAALFLVFVSSEDPATRQAWCPDVRAAWPTITATFSGEDSPKLAVIEVGQKPEWRDPQNVYRNHWNVKCIPALVRYQRVQGEVVETGRLVEREIIDQEKLQEFIGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6J8</accession>
    <name>A0A317X6J8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DENN-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_352465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470542.1">
        <property type="nucleotide sequence ID" value="XM_025607115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6J8"/>
    <dbReference type="GeneID" id="37109258"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004146">
        <property type="entry name" value="DC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03107">
        <property type="entry name" value="C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="UDENN" evidence="6">
        <location>
            <begin position="237"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="875"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="731"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1121" mass="124164" checksum="89B611BBAC44180E" modified="2018-10-10" version="1">MPFSSSSSSSSSSPPETSTTPLADYFWIAGVDGTEVLDTYRKLGDEYRANNATSPGPAVTDTIEEDADAEEAHDLLLDSLSRPISMAGTRSSFQRFSMRSGDSDTNENGSHSNRSSMTIKGAPSPRGSSFLEDFDFDKALFKFASERESFLSDLSSSAGAITPSSRPRSRLRTQKIVSEESPQPAGLLRSSIGSVRRHMAFRDMNSMKRQPSIARQASIRTSRRLSNYNSVIPVPQPLEISPTMHPLKRRFEPVLLDRYPTKGMSDELKLRGNFPDYVPMFAFPNDINIVSSDQRPRSTWHGFVMTTDNGSRLHAICVIIWIPLNQKAAEELEKRCEEWRKDNMTDEERELAASLGERLASERAKLSRLLAQLPTVPSGSESREQLEDEISAVEEKIGLMTDLLRPVRHGAASKIEGLTDGDTGFWIPRAYGILGREENMTSFWKEWLKAIVVPMTDGSIQRIPPNSPRMGIWQPLERYVMNLCTEAFSPNTSKTQVELAVRELRLFARKEAANELPGSRNTDLYALFRALSLQNIMILFEYALTESRIILLSSHTSMLYLATRALVDLLFPVQWTGVLIPILPARLIQALEAPCPYIVGIERRYEKVELPSDDFVLVDLDADLIESTVQPTPLPRHQRRKLLSLLQLAAPHHSRCGVPTGPPAYAVETYPFDSFMSENSSIFSSKAQSTQLAKYVSLNSSAFGQTSVPPNSYPPLIFNAYLHARYEQAASRGYSSRGPDRPGTGSTFKTGSPPSPRDISPTSGHFPSGPGSRNDSGTTLQASLREKRSGHFDAASRRSSSFGMDPRGGVPRRPSAPFLGHAPNLSVTTLNTDYNSGSTYAPSVYAQSTVAASTIVPQASAQPIHNSEGTCWVEGHCLQVQPWDDKATCAICDDQAEENMYKCTACKTVVHNRCALQICLVCPAAFHPEQVRAAFVRCFASLFYTYKKFLQPATGDKKKAGLTYNFNMEAFMKSLPGEHAEYIAVLQQTQGFNEFISERERANPKSRDPRMALFDEIILSKRNRGRSSIFSSRSMTDFLSDTSNHLWRTASATSFAGGSRSQNSLSGDYSRVVSRAPAKLDNSLMKEPRMIHGAPRVSKTANTARRKPLPKLMNGLAISPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X833</accession>
    <name>A0A317X833_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxyribonuclease Tat-D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_459722</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470478.1">
        <property type="nucleotide sequence ID" value="XM_025607852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X833"/>
    <dbReference type="STRING" id="1450535.A0A317X833"/>
    <dbReference type="GeneID" id="37109995"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000072">
        <property type="entry name" value="Hydrolase, TatD family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="314" mass="34781" checksum="7CB8431A8C7B76C7" modified="2018-10-10" version="1">MSDSSRPIRYVDIGINLSDPVFSGSYHGKQVHDSDLDDIVQRAKDIGCQKFMVTGSDLEESRRALQLAHHYPGFCYATIGVHPCQAKLFDEFPGGPSKMLDELKTLALQSKENGQAVAFGEIGLDYDRLFLSAKEPQLKYFEAQLDLAVEIQLPLFLHSRAASDDFEKLLAPRLAKLPKRGLVHSFTGTLEEMNRMVALGLDIGVNGCSLKTEENLDVVKAIPLDRLQIETDGPWCEIRPSHASSKYLKGAPELPKAVKKERWQKGLMVKGRNEPAAIAHVAYVISQIKGISVEEVCEAAWNNSIRMFGLGEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X888</accession>
    <name>A0A317X888_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_572354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471577.1">
        <property type="nucleotide sequence ID" value="XM_025614917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X888"/>
    <dbReference type="STRING" id="1450535.A0A317X888"/>
    <dbReference type="GeneID" id="37117060"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05362">
        <property type="entry name" value="THN_reductase-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009385">
        <property type="entry name" value="PRK12744.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="250" mass="26918" checksum="A32CC6A769440DFA" modified="2018-10-10" version="1">MALTNKVALITGGVKNLGAETARELASLGASLALHYHSTSSKPDASALISELQQNYPSIKVASYQGDLTSAAAVTQLFQSVKQDFGHIDIVVNTVGKVLKKPISEITEEEYDTMFAINSKTAFFILKEAAIHVTDGGKIITVVTALLGAFTGFYTSYAGSKAPVEHFTRGVCKELQSRRVSVNNVAPGPMDTPFFYPQESPEAVEFHKSNGMDGRLTMVQDIAPLIRFLCTEGGWITGQTIFANGGYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8M5</accession>
    <name>A0A317X8M5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1793-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_215115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471714.1">
        <property type="nucleotide sequence ID" value="XM_025606181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8M5"/>
    <dbReference type="STRING" id="1450535.A0A317X8M5"/>
    <dbReference type="GeneID" id="37108324"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF14">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G09910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="2">
        <location>
            <begin position="100"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="1">
        <location>
            <begin position="326"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="678" mass="73756" checksum="1E31272A2EBF750F" modified="2018-10-10" version="1">MPLSLWGKPGARQIVVTASFTPLLPPSYPLAVRSPYLSSWLPGNQASSLPSSSPQFWYGNNLTWSVIVRVDGQAYSLFGVPDALEGIQVATVTGGNFTSTHSTFMLTAGSKNFTLDFLSPVSPTNLLRQSLPFAYLTVSVSGISSSNSVQIYSDIDSSWTGQPESAAWEFSKSSTTSVFQLNPVGDAKFSENIQNQALWGETVYATRASRGNTLSSASGPLSAIRSQFVANGSLTNSHAKWTSDGVVAFTHDLGAITGDASVTFAIGHVREQAINYLGNAQTGYYRATYPDTTSAVSHFLDDYADAADEATKMDTLIQKGGESSYGTNYSDILALSLRQIYGGIELTIPDDTLDIKEARAFIKEISSDGNINTVDVIYASFPIFYILSPDYIRLLLRPIFEYMDSSNYTQDYAVHDIGTNYPNATGHNPKGEMMPVEESGNILIMTYAYELATNKTDISSTYSPLLRKYAQYLEAHGKYPEAQLSLNDALGKIANQTNLAMKAASGLASYGHMTSQLNYTNAGKSIADALYNGRLGTDPDGTYFTIQYGSDTWFLVYNHYADVLFSLDLFPEEAYNATAAFYPTVRKPAGVALDADLNWGQTNWQGFVAATVTGEARDMFIADMHAYIANGLNGVPFSDRYWVKDSTTGSAGEFFSFRARPALGSHYALMALQGANQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8U9</accession>
    <name>A0A317X8U9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha 1,6 mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_530871</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471740.1">
        <property type="nucleotide sequence ID" value="XM_025610771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8U9"/>
    <dbReference type="STRING" id="1450535.A0A317X8U9"/>
    <dbReference type="GeneID" id="37112914"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="40279" checksum="6F9AE44377A32A4E" modified="2018-10-10" version="1">MLLSNLKSSRYGRFAALTIPVFVLLCLLAFTWDPLPGPLPRQPTPQATPESAPAPKVVDSPKEASHNTIPTTRPVISAPAGDVVVGGAISGITDKIWQSAKNPHLSDDQHDWIDTWFAKNPSFRYELLTDASAVTFVRTHYAMRPDIIEVFETLPIPILRADLLRYLLVLAEGGIWSDLDVTCDKPVAEWVPAEYKDDKIEMIVGLEFDFEWRGEGTPIASQFCNWVFAAPPSSRVLQVVVDAVVAKIKEIAALNRVQIKDLTLEMLPIDVVDVTGPKIMTIAVLESLRQLLGRTVDDRDFHAIKKPKLIGDVLIMPGVSFAAAQSGYPQDQGDALVTHHYAGSWKEADAEAKEKKKQKQNGGQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X950</accession>
    <name>A0A317X950_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="10" type="ORF">BO94DRAFT_620622</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X950"/>
    <dbReference type="STRING" id="1450535.A0A317X950"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="240" mass="27017" checksum="395B42D56F6053DB" modified="2018-10-10" version="1">MAEEIQQKNNDHLVQSADPEHPANKIPDLCRRFYNWGWVTGTGGGTSIRHGDHIFIAPSGVQKEMMQPDNIFVLEFPTPKYPPSDRKYIRKPLNLNPSACTPLFLTAFEQGAGCCIHTHSQWAVLVTLLVEREKGPDACFEISNIEQIKGIPRGKGKGMLGFFDTLSIPIIENTAFEEDLTGSLEKAMEKYPDTYAVLVRRHGIYVWGDNVAKAKTQCESLDYIFQLAVEMHKLGLPWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9L4</accession>
    <name>A0A317X9L4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_562751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471816.1">
        <property type="nucleotide sequence ID" value="XM_025614314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9L4"/>
    <dbReference type="STRING" id="1450535.A0A317X9L4"/>
    <dbReference type="GeneID" id="37116457"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000041">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="122"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="465" mass="51069" checksum="309B1EF149414B95" modified="2018-10-10" version="1">MNILRSSGSFSWALRSCQRPRAFRCQTLPLPRRQFHAALPLWGIKSQVLKDVGEGITEVQIIQWYVEEGAYIEEWKPLCQYQSDKAVDDITSRYEGVVKKLHFQADDTVPTGKALCDIEVEAGKYPDDSPPPAPKIEPVPATPAPTESRPLQPVQATSTPAKESTNNTYKSPYATLATPAVRGLLKIHSVNIEDVRGTGKDGRVLKEDVQRFIAQRDLAPAALSTVSEVQDETVAKLTPIQSQMFKTMTRTLETPQFLYTDELNIDTVTVIRKKLANDPKDPRKISLLSFVIKAMSLALNEYPLLNAKIDTSDSAKPRLIMRSKHNIGVAMDTPQGLLVPNIKDVGSRSILDIASEIVRLNARAKEGKLTPADLSGGTITVSNIGNIGGTYVSPVVIPNEMAILGIGKARTVPVFDDAGHITKGELVNFSWSADHRVVDGATMARMANVVRQLIESPEQMLLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAJ7</accession>
    <name>A0A317XAJ7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutamine repeat protein-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_542881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471358.1">
        <property type="nucleotide sequence ID" value="XM_025613113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAJ7"/>
    <dbReference type="STRING" id="1450535.A0A317XAJ7"/>
    <dbReference type="GeneID" id="37115256"/>
    <dbReference type="OrthoDB" id="2530523at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="33733" checksum="F8A40666885ED41A" modified="2018-10-10" version="1">MDPNVPGFPSAMQQTAGFSVTSQSPQQFPYYPNAIPSYPQPKPASHPPPQQQQHSTFGAVPMQAGPSGAMMPSGFPQQSSGLAANQRDGLAGPHANFSAPFAQPPVPTSMGQFLPPQATATSSLPATTAQSFPPNMASLPATNMIPAQQQRPVPQQTPLQSTSQPAAQSPATTAREKARVSTLLDINSMLLQEVMNLQAAGKAGGPSQGSQESNPSPGSDQTPDKTTQRPSPEYVECMRRLQANLGYLATIADRAKKSGGVPPAAPAIMSPPPNMPSMNEIYNKLNELFPRTAQGGVGTPQPSPQALQGNGRPSPSPAMENVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAK6</accession>
    <name>A0A317XAK6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_541748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472387.1">
        <property type="nucleotide sequence ID" value="XM_025613055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAK6"/>
    <dbReference type="GeneID" id="37115198"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="190" mass="20372" checksum="BC331C64D7432E43" modified="2018-10-10" version="1">MDDDPPEAGWQSDDMIVTRKVAKHGLLRSLAPTTDVRCVTQMKLALLHAAQGRVAQKGNWSRKTLRATKDPGYGPPPLVRESTQADDRVGPDCWDRGKTGLSAFEGTLRAKQKKKNTPERRRLAAAMWAAASPGAAMALSGGIPESQEACPSTQGSRGVWLSPPQRPWMAGGAGGELARSVVSACDRYHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAZ5</accession>
    <name>A0A317XAZ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_552600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472524.1">
        <property type="nucleotide sequence ID" value="XM_025613609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAZ5"/>
    <dbReference type="GeneID" id="37115752"/>
    <dbReference type="OrthoDB" id="4487982at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016436672" evidence="1">
        <location>
            <begin position="30"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="421" mass="47909" checksum="FEFC6A79D45DD7D1" modified="2018-10-10" version="1">MLIPKSLILSIQLILRGLSPGSLVKFTWCYPWLPNGIMDLNGYIPRSQPQIVSLELYTQAGDETGTGQSSIAEEISIDGLVRLRYLTCLVWHGICPCRHALVLDTCIWQNSGTLERLDLRFLRRVVDRMLLVTHAYNHNFIEFSNLQMLILENMFISESKVITSLLSHPSITPLYLSCIFIGRIILSPKPEAADFHRYYNKNCLYWACYGLFQKLQKVLRTSIDKLLDLIQGLLNLYCSQACLPFKNTVELLYQFYLEPASDLSKCEGLLGPCASRPFALMGELLDYLRLFTSQPVPTSADVMQLVRRLAHPVPSLDTVERFLSRHCLQQFPSLRAVVQLLDLFYLQPGLSLAQAEEHLSRYSTQPSPPLGLLIEYLSELKSQQPCVSTADIAVRMLQHMRALGNREREAEDAWNNLLRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB27</accession>
    <name>A0A317XB27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_511561</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470481.1">
        <property type="nucleotide sequence ID" value="XM_025609777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB27"/>
    <dbReference type="STRING" id="1450535.A0A317XB27"/>
    <dbReference type="GeneID" id="37111920"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF458">
        <property type="entry name" value="SODIUM-COUPLED NEUTRAL AMINO ACID TRANSPORTER 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="149"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="553" mass="60273" checksum="A47797E9554252AD" modified="2018-10-10" version="1">MPSDERHLSLLADKNGPGGPESQSLLSESPSQDHELVTHAAPASSTPRGQPHQSSISQPAPDGQRRTPRTLNRVRFDLDDDTEDERHSNGHSRDSEDSWLEEEDYGRVDRNRSARQMIPLLTDIEAPSVTLATSDEFFPEEHLENARPRSGMRMAFMNMANSIIGAGIIGQPYALRQAGMMMGIVLLVVLTIAVDWTIRLIVVNSKLSGADSFQATMQHCFGKSGLIAISVAQWAFAFGGMIAFCIIVGDTIPHVLSALFPSLREMSFLWLLTDRRAIIVLLVLGISYPLSLYRDIAKLAKASTLALISMIVIVVAVITQGFRVPPDSRGEVKSLLLFNNGFFQAVGVISFAFVCHHNSLLIYGSLKKPTMDRFARVTHYSTAVSLLMCLTMGISGFLFFGSQTQGNVLNNFPSDNILVNIARLCFGLNMLTTLPLEAFVCRSVMTTYYFPDEPFNMNRHLIFTTALVVTALAMALITCDLGAVFELIGATSAAALAYIFPPLCYIKLSNASHKAKIPAYACIVFGVTVMGVSLLQAVMKMISSEGGASTCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB88</accession>
    <name>A0A317XB88_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_136249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472540.1">
        <property type="nucleotide sequence ID" value="XM_025605696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB88"/>
    <dbReference type="STRING" id="1450535.A0A317XB88"/>
    <dbReference type="GeneID" id="37107839"/>
    <dbReference type="OrthoDB" id="5342292at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF108">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="30"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="419"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="468" mass="50905" checksum="B108049D8431F3BD" modified="2018-10-10" version="1">MPEQDYGYLRTISLVTQILCLAMVSAFVALRLLVAVSYKHHINVEDAFCFLSWIFFTAYCILALLFATLGGSKPLPTLTPSQTILIYKIFYVLTVLYVPMVLSAKITLLAILARIFVLRPSQIISVRVVLATTVVYYIIIFFVKVFICTPVSVFWLSPTLETKCLSKSAILLADAIMSVITDLAILLLPLLLMWPLRLSMLKKCKVALMLGAGGLAVGFSLYRLVLVIKEEQELDSTIIYMKILLSGNAEGGFGLICSCIPAIHILLTRLRGKPTSTLESSFASGSGGSSSRRKSSQGRKISGSGSGGSGSGTTATNPINNPGAFFGSMSTTTSPMSPAGRRRSDRLGSGPRMTFGNGDGDVFTSIHDHNHNNHNINTNDGGEEGEGVVEEGEEDDYIDDYHDYTMMFVPRTRSSRFSLELRGEGENSNEGGNEKGDADEDEEGGGWTKMFRKVSWGGKSRRDSGNCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBI9</accession>
    <name>A0A317XBI9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_507316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472674.1">
        <property type="nucleotide sequence ID" value="XM_025609606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBI9"/>
    <dbReference type="GeneID" id="37111749"/>
    <dbReference type="OrthoDB" id="4453902at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="254" mass="29315" checksum="A1D0689F9B725C76" modified="2018-10-10" version="1">MTAIDRRPEREARRERLGAIRKAVEDLEYAYLSAADLDSAGIHLSPMSLTDDDLLPNFFHLYKGQVQMTSDGYISDSWPLFDCGAWENARDLEDFLDKLVCHSELPQSDKYPIGPRYRDFGDFINFGQLLECRPQRWQVQAAWDMPDHHPHLKAMVINEAVGDERLLRGEVLTIIDIMRGRLTHKVTRAYVNAPILLFSFMDTCARALEAYLDGENLVIRVTRLYDFKTEEDADFSLSICFAKWWMGQVTELST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBS1</accession>
    <name>A0A317XBS1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_531034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471893.1">
        <property type="nucleotide sequence ID" value="XM_025610805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBS1"/>
    <dbReference type="GeneID" id="37112948"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="80" mass="8600" checksum="5F38BDD5C16C5340" modified="2018-10-10" version="1">MGNSAWVHSGRLSFVPLEDECDYPLIESSRSPRGLCFTPSIPSSRSDIFKPSTSISVFILTGSSLILPNCACLICSSLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBU2</accession>
    <name>A0A317XBU2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">BO94DRAFT_219949</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBU2"/>
    <dbReference type="STRING" id="1450535.A0A317XBU2"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="222"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY95152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="514" mass="55327" checksum="A374DB429E3A2F54" modified="2018-10-10" version="1">MRPLSRTALRPYVCPSCQLGRLPARRRYASHSSSNGPAPEIYDVVCVGGGPAGLGLLAALRAFPATSKLKVALIETQDLHKARSWSLDAQHFSNRVSSLTPSSVSFLKKIGAWDHLDTSRAQPYQEMQVWDGETGSRISFDWSMETSAFEDLRTVATMTENSNLVRALLSRIAASGDENLSLFSNSTVSSIANGSDNPDGPDLSAWPVLSITPTGSAPSQPPTRIAARLLVGADGINSPVRRFADIATDGWDYNRHGIVASLSLADLDPAPFPVGMRTAYQRFLPSLGGPIALLPLPNNHATLVWSTTVENAAYLKSLSPKAFLAMVNAAFRLSVTDLQYMLRMERPATAVSDLEDPHENELSWRLEHTPQPSHIPPMVTGVQEGSVASFPLRFRHAATYVSPRVALVGDAAHVIHPLAGQGLNLGLGDVASLAQTIEYAVHHGMDVGDLLTLERYAGDRYATNAKIGGACDVLHKLYNVPGNGPVAWARSLGLDLVDRVSFVKGLLMKGAEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCT5</accession>
    <name>A0A317XCT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fungal-specific transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_563013</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472158.1">
        <property type="nucleotide sequence ID" value="XM_025614327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCT5"/>
    <dbReference type="STRING" id="1450535.A0A317XCT5"/>
    <dbReference type="GeneID" id="37116470"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF74">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="333"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="79796" checksum="8A621CD0429D3DBF" modified="2018-10-10" version="1">MSSGNRLEAASMSFTADHVPVPPRPPLSRRRDKPQLSCNTCRRRKPVSQSMLTHYARSRCDRQHPCSGCASRGDPCVYADSQHRSARPHAPRQAVVPEMQDRLAQLERLVHSLMPGSALSSNAANESPLQDSQLDCGSMRVSASELRYVGGDHWAAILDNIAELKDHFDREEELSITTSPDDEPDSTHALLLYGCRRATSREELLEALPPRNIVDRYLSRYFNRMDLVSTSAVHGPTFLREYETFWAEPSKVPIMWLGLLFSMICLGVQASNASTLKELDAEQQALQIDLYREKVVQCLVMGEYTKCGPYVLETVIQYVYIEFCLHSDADQDIWFLLALEVNLAMRMGYHRDPSHFPGLAPVQGEMRRRLWATVLLGDILISSQMGLPRMVPHEKCDTAEPRNLNDDDLETPGAELPPSRPETEATTATGVIARRRMLVALGSISDLAATVQSSPYSEVLRVDRVLHDAASSLPPPLRIESPLGISFTDSPQVTMSRLFLRHLFYKGQLMLHRRFLFTARPAGEVDTFAYSREACISASLGALELQHILDEETSPGGQLQSLQWRVTSIINHQFLTATMILCSLLHRGSPLPQAEEIQRALRRARVSWMRRSATSREANMAVKTIRIVLSRTAEKRPAPASDGDADIGGNALDSEILDPPDLSWLADYATDDPDLPSTFLGVRGDRPDVFPFDINIQRGGNEWMGMNWPGTEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDJ0</accession>
    <name>A0A317XDJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_529635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473002.1">
        <property type="nucleotide sequence ID" value="XM_025610486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDJ0"/>
    <dbReference type="STRING" id="1450535.A0A317XDJ0"/>
    <dbReference type="GeneID" id="37112629"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF57">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016311106" evidence="3">
        <location>
            <begin position="24"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="64"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="433" mass="44519" checksum="768E0E60CAF9C3D1" modified="2018-10-10" version="1" fragment="single">MTPTHQLLLLGALGILPWASASAASLPQHVSSHINLVHRSEPGAKLTRRGKHGIAAVSESNGFWFGSFDVGNSKNLHMLIDTGSSDVIVNPGLYTPGSSSASLNLTFENAYGTTESDGSGTGTVAGTLYNDTVQFGSLSAAQTVGSATGTVLIPGDGIVGFAGVEVAQFPNGAPPFFHSLCNQGQVSSCRFGLALGKNDTGVQVLGELDSSLFQGNLTSTSVIQEWAFFADLALENTIIASDILVELDSGTATVTGPVDEVLSIFEATSIQAVVQNTTDGVTVTGYFPCDQPPTLGFSIPSQSNASTAEKTDSSLISHQSTIFNIAADQWIAADNGNNNCTAILSGMTVASYPTLWVVGQPFFRGLYIDHNLANATVGLATAKTQGTTVSSGTPTPSSVASSSPSVIATSAASSGMSVHAPLLLLSFLASMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDJ5</accession>
    <name>A0A317XDJ5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_530534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472563.1">
        <property type="nucleotide sequence ID" value="XM_025610693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDJ5"/>
    <dbReference type="GeneID" id="37112836"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="85" mass="8963" checksum="7E7D0C69EC1BFD9D" modified="2018-10-10" version="1">MHGNAAGCISLAVPWGYPRPPGNGFNPGVMDRFFKATTLPCPSWESRVESRILHGILDDQGIGCIHACGGVWEVIQVGAGCSAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDX8</accession>
    <name>A0A317XDX8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_619831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473515.1">
        <property type="nucleotide sequence ID" value="XM_025616893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDX8"/>
    <dbReference type="STRING" id="1450535.A0A317XDX8"/>
    <dbReference type="GeneID" id="37119036"/>
    <dbReference type="OrthoDB" id="5415522at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="98" mass="10440" checksum="B3FB3F67B19E8EC7" modified="2018-10-10" version="1">MQENGTNLVEILSCIGVKAMPYFNGHAKKEGVYGVMKIADGNHWCSRDYGSGAANPNSYHYSNSDGSYYYSNPNGSTYHNNGNGGSTHTPPSASGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE65</accession>
    <name>A0A317XE65_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="16">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_571823</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="16">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="16"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471979.1">
        <property type="nucleotide sequence ID" value="XM_025614888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE65"/>
    <dbReference type="STRING" id="1450535.A0A317XE65"/>
    <dbReference type="GeneID" id="37117031"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000460">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 16" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="158"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="348"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="577"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY95218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="608" mass="68258" checksum="F106AF5E829E3115" modified="2018-10-10" version="1">MPIPVDSAKSINKKRKRKHGARAATETEDASPKPAVENAATEVTEPSTEKKKKTKKVESTKEAEKEEKPKKRKVDDSGDEDENDSEEEVRQADPEDEEEGEGEETGNGADLPSLDAVRLPQTDSEPKKFTELNLSEKTMKGIQDMGFETMTEIQQRTIPPLLAGRDVLGAAKTGSGKTLSFLIPAVEMLSALRFKPRNGTGVLVVSPTRELALQIFGVARELMAHHSQTYGIVIGGANRRAEAEKLTKGVNLLIATPGRLLDHLQNTPGFVFKNLKTLVIDEADRILEVGFEDEMRQIVKILPSEERQTMLFSATQTTKVEDLARISLRPGPLYINVDHRKEHSTVEGLEQGYVICEADKRFLLLFSFLKRNIKKKIIVFFSSCNCVKYHAELLNYIDLPVLELHGKQKQQKRTNTFFEFCNAKQGTLICTDVAARGLDIPAVDWIIQFDPPDDTRDYVHRVGRTARGVNGKGRSLMFLQPSEVGFLKHLKEARVPVVEFDFPANKIVNVQSQLEKLIGQNYYLNKSAKEGYRAYLQAYASHSLRSVFDVHKLDLVKIAKGFGFSTPPRIDIQLGSSLSRDKKQQQQGRRTYGSQPKGLKFKRKHDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE96</accession>
    <name>A0A317XE96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_541451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473416.1">
        <property type="nucleotide sequence ID" value="XM_025613047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE96"/>
    <dbReference type="GeneID" id="37115190"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="288" mass="31940" checksum="6C0D3BB879C099FC" modified="2018-10-10" version="1">MDDGSELFPYARLIQAPRASQSGSPSYEMDSAESGTRVRGEEVIQIENDISSTDSQVEMPHAHLEPETRTAETQTQTQPPQTNQERDPSETDSVEACSGCFICDVSTTETDLPETHLVTGTIGDGDSTAVDGLSISPVTTPSPHGTVIDDHDHHNDDNDGDSSDSSTLASLDIFSHTATASSSQSEYSDMDDDDSLPETASISDDNDSEYFDIDDSEYDYYGDDEDDDDDVGPPRECVCRDVEEDLRFHEWDYLMYWRNTSPELWVDWIDRELVGLGYRRAVLGWGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEH5</accession>
    <name>A0A317XEH5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">TrkH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_606679</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472109.1">
        <property type="nucleotide sequence ID" value="XM_025616522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEH5"/>
    <dbReference type="STRING" id="1450535.A0A317XEH5"/>
    <dbReference type="GeneID" id="37118665"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF37">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="584"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY95348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="681" mass="75773" checksum="6E91F1AF71E0ADE6" modified="2018-10-10" version="1">MAVLPPFNFLTLHYAYFIATPLICSVIFWGSATPLRSVSYVDSLFMCVSAMTGAGLNTVDLSSLNSFQQSVLFALLFLGHAILISITVLFVRRSAFQAKFKGISLERARKRLAQHMMRHDPSLDPIQESNVSVEPHQVAKSDDASYGVKNTVTAEAAPAESSSEALDGDPIQWVDDDQVTLGQMKARQNHHHHRVFPMVGVGARLDLNNHPRDATPRLTQSEEDNLPALKGFIKGTQKYFKSKGSIARNSQFYGLTPEERERLGGVEYRAITFLLVIVALYWVLTVLGGIIGMGGWLAVNHPDISRSNGLSPFWTGAFFAVSAFVNSGMSLLDANMTAFQTNAYPLLTMAFLILAGNTLYPCILRFIIWVLRCLIPKTPSWATWRVTLDFILDHPRRVYTNLFPKRHTWYLLGTIIILNAIDWAGFEVLSIGNKEIESLPKGYRVLDGLFQASAVRAGGFYVVTISDLRQGLLVLYVLMMYVSAYPVLLTMRNTNVYEERSLGIYAHDNTDDNNEGKPSPNMAIQLIRHHLLGRQDASTPEASRSYFVHQQLRSQLSHDLWWIALAVFLIAIAESSNYSHMPVAYSTFNIIFEVVSAYGCVGISVGFPGSNASFCGSWHAISKLILAAVTLRGRHRGLPVAIDRAVMLPNESLEWAEEEDAAMRREKSRAWGSDKMPVGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEI8</accession>
    <name>A0A317XEI8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ras small monomeric GTPase rasa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_16333</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473372.1">
        <property type="nucleotide sequence ID" value="XM_025605883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEI8"/>
    <dbReference type="STRING" id="1450535.A0A317XEI8"/>
    <dbReference type="GeneID" id="37108026"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04138">
        <property type="entry name" value="H_N_K_Ras_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY96611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="212" mass="23831" checksum="EA5ABCDCD0D301B4" modified="2018-10-10" version="1">MASKFLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCVIDEEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSITSRQSFEEIMTFQQQILRVKDKDYFPIIVVGNKCDLEKERAVSEEEGEALARQFGCKFIETSAKSRINVENAFYDLVREIRRYNKEMSSYPSGAGAGSRAPEGKMDVSEPGDDAGCCGKCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEN4</accession>
    <name>A0A317XEN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alkaline phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_553308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472179.1">
        <property type="nucleotide sequence ID" value="XM_025613649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEN4"/>
    <dbReference type="STRING" id="1450535.A0A317XEN4"/>
    <dbReference type="GeneID" id="37115792"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032506">
        <property type="entry name" value="SGSH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF6">
        <property type="entry name" value="N-SULPHOGLUCOSAMINE SULPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16347">
        <property type="entry name" value="SGSH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="3"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="N-sulphoglucosamine sulphohydrolase C-terminal" evidence="6">
        <location>
            <begin position="289"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="449" mass="51454" checksum="1C63F9E1BB125785" modified="2018-10-10" version="1">MKFTHCYVTNSICTPSRATILTGTHNHVNGVFTLADKLNNRLPNVAKHMQSGGYSTAMIGKWHLGEGREYSPSGFDYWSVLPGQGGYFDPEFITSDGNGGGGEGVRGVEKGYVTDIITDKALTWLKGREEGKPFFLMCHHKAPHRSWECRPDHRGLYTEDVAVPDTFNDEYKHRAKAAGAAKMRIQSDITYFDLGLVQPEGGEEEVGELFLNGDRKVPVYGDEGIENVRLVDKDTGEVFRFKSGEEVKRFKYQRYLKRYLRTVHSVDLNVGRLLDYLDEEGIAEDTVVESFQMPFLIRYPRMIRPGSVCEDIISNVDFATTWLELAGLRVPSYMQGVSFVPLLRGCTPWDWEQVAYHRYWMHRDSIHNAYAHYGVRNQRYKLIYWYAEGFGLPGTGEGGQPREWELFDCVEDPLELFNVYYEERYQGVVGELRRELEEKMLEIGDSPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFU0</accession>
    <name>A0A317XFU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_552524</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472421.1">
        <property type="nucleotide sequence ID" value="XM_025613605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFU0"/>
    <dbReference type="STRING" id="1450535.A0A317XFU0"/>
    <dbReference type="GeneID" id="37115748"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY95660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="82" mass="9366" checksum="5927BE37E04D352A" modified="2018-10-10" version="1">MPAYELRSGSVADLKYRRLTELNARLKEDLDRPRVKVSEAALSLINYCNNTRDFMVPSVWGQVDKREDPYAPQQQGGCCTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XG16</accession>
    <name>A0A317XG16_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Peptide hydrolase</fullName>
            <ecNumber evidence="18">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BO94DRAFT_482576</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">May be involved in vacuolar sorting and osmoregulation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="18"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472531.1">
        <property type="nucleotide sequence ID" value="XM_025608896.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XG16"/>
    <dbReference type="GeneID" id="37111039"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000251">
        <property type="entry name" value="Ubiquitin ligase complex F-box protein GRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000057">
        <property type="entry name" value="Vacuolar membrane protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053975">
        <property type="entry name" value="PFF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053976">
        <property type="entry name" value="PFF1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF58">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22250">
        <property type="entry name" value="PFF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22251">
        <property type="entry name" value="PFF1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7 18" id="KW-0645">Protease</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="13 18" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1022"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1077"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1108"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1140"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1172"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1298"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1331"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="1359"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="24">
        <location>
            <begin position="170"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="21">
        <location>
            <begin position="797"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease transmembrane" evidence="23">
        <location>
            <begin position="1075"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar membrane protease C-terminal" evidence="22">
        <location>
            <begin position="1386"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1207"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="1225"/>
            <end position="1241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF22250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF22251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="PWY95770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1610" mass="178069" checksum="26B9D165DE187CAC" modified="2018-10-10" version="1">MPRQRQPARFSSEAPSDTSTSTSPDRTADDDTDFFTAQANDSQSSVGVATRDTHIQNPTPMYLPPIGRLPPEILIAIFAKLSSPSDMLSCMQSITASVGQPNSFFPYSQLIRRLNLSALTDGVSDGTVVPFAQCNRIERLTLTNCSKLTDKGVSDLVEGNRHLQALDVSELRHLTDHTLQTVARNCSRLQGLNITGCVNVTDDSLITVSRNCRQIKRLKLNGVTQVTDKAILSFAQNCPAILEIDLHDCKLVTNPSVTSLMTTLQNLRELRLAHCSEIDDSAFLELPRHLSMDSLRILDLTSCESVRDDAVERIVASAPRLRNLVLAKCRFITDRAVWAICKLGKNLHYVHLGHCSNITDTAVIQMVKSCNRIRYIDLACCTRLTDASVQQLATLPKLRRIGLVKCQSITDNSILALAGSKAAHHSGGVSSLERVHLSYCVRLTIEGIHSLLNSCPRLTHLSLTGVQAFLREELTVFCREAPPEFTHQQRDVFCVFSGEGVNRLRDFLNRIIPPPPPTRDMTEATMYDDDEELDEEENQVTGLMHATAATAIHDDDYIDIGHTHAMGWRSDHQHGRRKVVVIQRHRPHYCEIPPPTAFSTGAIPLRIARCYLPLRSSAQLSSAQRNAPRHPMAPLRLSRANPLAFTRWPVTLITTVVYLAFVIPLLIVHHVVPSPPNSNPNGLDIAQAWADLQVLTDGFHPYNSHRNDDVHDWLLRRIHEILDAAPSADEYRSVDEEKPDAFVFDDTRSNLTFVGNSLSSSNTAVYFEGTNILVYVRGWEDDEERWWEEPNGAPTGKGGVLVNAHYDSVSTGYGATDDGVGVVTCLQLIKYFMTPGHAPRKGLVVLFNNGEEDYLNGARAYGQHPIAKFPHTFVNLEGAGAGGRAILFRSSDTEVTRPYMRSKYPLGSVLAADGFATGVIGSQTDYVVFEGDLGLRGLDVAFMEPRARYHTDQDDSRHTSKNSLWHMLSAAVATTEGLVSDSSDQFDGAPKDDAKVPSGSGSRAVWFDLFGTTFVVFQLHTLFALSVTLLVVAPLTLLGTGIALTRADKMYLFRTSAKVEDSIETVPLQGLRGFFRFPFLFAIPTAVTVGLAYLVTKVNPLIIHSSEYAVWSMMLSAWTFLAWFVSRVADFARPSALHRVYTLTWMFVLAWVLLVISTVYENKWGLAGGYSVFFFFSGTFVATWISYLELFALPRKSEYASQFQPTSRRASSYGGSRLGTASGEDHDEEDHDAEEEEEEPTESTSLLGGGQRTTFANYVRVSGDNRDSDTDEHHHPDVYRHEQRWSASLPKWTWTLQFLLIAPLVLIMVGPLALLLTSALHQTGQDGGSSLFIYVAIAALTTLLLTPLLPFVHRHTYHIPVFLLLIFLGTLIYNLVAFPVSPTHRLKLYFIQELNLETGVTTVSLSGAAPYVRDAASTLPSAANQNITCIDHVVRGTRCSWPALAPRVVPDTPISDWLDFTISNPSKNADDTEKPNHARITLSGRNTRACKILFDSPVSTFSVLGSATDPRFPISSPLGTKEIRLWSRTWENEWVVDVSWTGNSTSTSTPITNEEEKALTGRVVCLWSDANTAGLIPALDEVKQYAPAWVAVTKGADGLVEGSKGFSIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XH46</accession>
    <name>A0A317XH46_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DUF1479-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_481176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473161.1">
        <property type="nucleotide sequence ID" value="XM_025608849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XH46"/>
    <dbReference type="STRING" id="1450535.A0A317XH46"/>
    <dbReference type="GeneID" id="37110992"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="477" mass="53357" checksum="58D3AFD1A9E4A569" modified="2018-10-10" version="1">MSKFLSKTAIRAASTSSSASQMTKAAGDISSVFPSLRPDYKPEPLPSRFKDLKLRYFEQNEEALKQSWKRLLPSMEEEVHKIKSKGSDIISSVKYSDVINGTVPDHVLAEIRHRGSVVIRNVVSREKALELKERIKDYAAANKERVKAFPPDSPAVYELYWTPSQAEARAHPNLLDTQRFLQRLWHSSDPKTPISTRNPLTYADRLRIRQPGDSKFTLGPHMDGGSLERWEDPEYSKVYTKILEGNWENYDPWDAKHRVSAKMDLYNGAGACSMLRFFQGWLSMSNTAPGEGSLHVCPMLIHSTAYAILRPFFNTETLQPALDNTFPGSVPGACQEYNPITHPHMELETTMVSVPEVEPGDFVAWHCDSLHSVDKEHRGTGDSSVLYIPATPMCDMNVEYLLKQRQAALAYSPPWDFPGAGGPGEMGFQGALDWNSVNVEGLRAMGMGNQPWEITDDMSEGEKVVIEAANKACFGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XHP4</accession>
    <name>A0A317XHP4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_506251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473521.1">
        <property type="nucleotide sequence ID" value="XM_025609568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XHP4"/>
    <dbReference type="STRING" id="1450535.A0A317XHP4"/>
    <dbReference type="GeneID" id="37111711"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY96760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="268" mass="29629" checksum="5D61DBBDD4CE4ABC" modified="2018-10-10" version="1">MPFNYSQVLIIGATSGIGHALATILVQNNIPVVIAGRRDANLNEFAAQYGPDKVKTKVFDVTNLEKIPQFASEVLAENPQIDFVFVNSGIQRPFDFSQPATVDLSIFDQELVTNYTAPVYLSKAFLPHLQAQNKPTGLMFTTSQMALVPMMRCPNYGASKSALHHFILALRTQVSEGPGNVKVFEIFPPAVQTELHDAKHQPDLKDGHLIGMPLNEFVGEVWGQLQQGEEQIAVGSAKEIFDAFEPKRQEMYAGMTAQLNVLIKQFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317USY8</accession>
    <name>A0A317USY8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_579956</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000068">
        <property type="protein sequence ID" value="PWY64725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461310.1">
        <property type="nucleotide sequence ID" value="XM_025615295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317USY8"/>
    <dbReference type="GeneID" id="37117438"/>
    <dbReference type="OrthoDB" id="5421765at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY64725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="384" mass="41193" checksum="9FD4283110805F68" modified="2018-10-10" version="1">MAALFHARQEPTRASTSSFTPAYSPLTSSRTTTSHTPTISSFSVTSSTTSANVVNTTIPSSTASSLPESRHGVSNGALAGAVVGSIVGTALVALIAAVLFFRFRRRPTPNPQTPSPPDQGLEFSKLPTSQTRPIAASRPVRGEQFPPLDLVSFIPPPADDQSVSARIHTFFDHVSLHVDNYYAPGSHEPTPLTAEATIQIETYRSPLIPGPLATILANRRARRAVLTHVLARTLLQAIQPGGPLYPPFCESQQIDVAAPVTGQDNATFAWRMLTARLHAKSLDTTSGVVQGHIIALAGGFTQAFAPFHNPQLSEADRQRHLSSVVRECAELSVWLFTQPCSFNFVWTSSPGSIVIFPAVVKTSDEQGNPLPVSQKMVEETTAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZ96</accession>
    <name>A0A317UZ96_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_551362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461827.1">
        <property type="nucleotide sequence ID" value="XM_025613541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZ96"/>
    <dbReference type="STRING" id="1450535.A0A317UZ96"/>
    <dbReference type="GeneID" id="37115684"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052358">
        <property type="entry name" value="Aro_Compnd_Degr_Hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35563:SF2">
        <property type="entry name" value="BARREL METAL-DEPENDENT HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="10"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="299" mass="33302" checksum="55E231AD392DAC1C" modified="2018-10-10" version="1">MAELVPANAWDTHIHVFDPDTFPYAVPRSYSPKAAQMAEYPTAVTGCRNIVIVHASMQGVSPAPLVDTLSKQQQMPGYTLRGLATIDPYTITDQELDALHAAGVRGARLHEMAWGHGKQSGGSDIIKKVTALADRLARLEWAIGIFCPISAWAAMADTIRNLDPRIQMVADHFGGTFPGEEDSPEFATFLGLIREKRVWVKVSGFERLYHGHASGMQAIEPIAKAVIAAGPDRIVFGTDWPHTQLGVTRKGKTDQQRLEEVEGFREVNDTEHIRTLREWIPDEETWQNLWVNNPARLFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V145</accession>
    <name>A0A317V145_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Deoxyribonuclease TatD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_504030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461833.1">
        <property type="nucleotide sequence ID" value="XM_025609497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V145"/>
    <dbReference type="STRING" id="1450535.A0A317V145"/>
    <dbReference type="GeneID" id="37111640"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY67111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="317" mass="35580" checksum="B1E5FE0AFC036717" modified="2018-10-10" version="1">MSPLRFADVAVTYTAPQFHGIYRGKQYHAPDFSEVITRAKTHNCEKMMLTSMNLEGFHTNLSLVREFPEICSLTLGVHPYHVKEIYSPDGEGDGKEYLAQLREVGQRVLQEGDGGSPLVAFGEIGLDYEYLERADKEIQIRAFREQLEIAVEMQLPLFLHVRESCADFVEIVSEYLPRLPKKGLVHSFTGSREEMIQLVGMGLDISVNGVSFRTDAGLDMVRAIPLERLQLETDAPWCEVLGGDERISGYLRGARELPGVRKHNKFILGQMIKGRNESCYMERVALVVAGVKGVEVEVVARAAWENSVKMFGLGVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V180</accession>
    <name>A0A317V180_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS drug transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_591091</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000050">
        <property type="protein sequence ID" value="PWY66838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461774.1">
        <property type="nucleotide sequence ID" value="XM_025616087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V180"/>
    <dbReference type="STRING" id="1450535.A0A317V180"/>
    <dbReference type="GeneID" id="37118230"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF189">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="4"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY66838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="517" mass="56212" checksum="B0BA51572CE95329" modified="2018-10-10" version="1">MERIFLACAAVDLVAVMDQTTLAGSLSIIGKSLNASNQTSWISGGYFLTSTCFQLLYGRLSDIWSRKYVLFVGFGITFIGLLASSLAQTATQLIIFRAFTGIGGGGLMSVAQMIVSDVVPLRERGKYQGILGAVVAIGNGIGPVIGGALASVSHDSWRWIFRLMLPLTVIATLAVMFFMPLRKVTGEWKAKLKAIDFFGALLALGGTALLMLGLTWGGSEYPWKSAHVIATIIVGFAVCVTFMMWQWKGAPYPLVPIHMFKSRIVNGACLTMFINGWNLMVQLYYIPTFYELVFNYSTTKSAAMLLPITLVQTFSSTVSGLIVHWVGRYREPILFGWMVWAVGLGLISTLDKTAGLGKQVGYGILTGIGTGSTLQPALIAVQAGVERRDMAIVTSFRNFIRNLGGTLGLAIAGTIINNLISTAISTLNLTPTEQQSFLSSPSKYLSQLPTEEAEQVRALLIPTYRKGFRIVFTANATLAALAFLLAVGLIPQVTLERADDERLREQARRRVEGEIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3P7</accession>
    <name>A0A317V3P7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_305200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000046">
        <property type="protein sequence ID" value="PWY67971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462020.1">
        <property type="nucleotide sequence ID" value="XM_025606777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3P7"/>
    <dbReference type="STRING" id="1450535.A0A317V3P7"/>
    <dbReference type="GeneID" id="37108920"/>
    <dbReference type="OrthoDB" id="4159781at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF10">
        <property type="entry name" value="SIGMA-70 REGION 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="52660" checksum="602B793272C120FC" modified="2018-10-10" version="1">MSRDHDLGSGTTEYQFVFGKDQPGTRSHAMRQFWRRRHQALQSSVRISRPQLRALLPKEYGSEGGGFQADVAQSQGKSPDPPANNALEPGSRPPNPQPTGIDAAQESKFSILQGPSTKFPIDLSPKNQAIFYSWLDLHTSSTPDTSPNTRFHPIQDVWLPMDLSNSAAFCALMAHASAHVAHLQRQTKSLESEKFRTLAVGIIAKWLADERRSTQDATLAAIARLLMFEKYWAVDDQWRAHRNGLFSVFHARGGLQAFKSDWRLHMVLFLAFSMSEPSRLSSPAHAWEISEYFVPSAVHPAIQLRMVHNKPKSFHGIHIYPEVYDAVLFLRNYTDHPDSPDQNGHLDVQGHKLICLFILVLIMQESLYSSEPELNHSFAYKLPELNNSLYQKRLSWVGSPQKLRELLMGDHTMLGPPTREFIVKLEQNVVYLNEDARGAIEKCLLNTLLWRHESLDAISNLNVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5B6</accession>
    <name>A0A317V5B6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing histone demethylation protein 1</fullName>
            <ecNumber evidence="5">1.14.11.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">[Histone-H3]-lysine-36 demethylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO94DRAFT_298153</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 25">
            <text>N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:42032"/>
            <dbReference type="Rhea" id="RHEA-COMP:9785"/>
            <dbReference type="Rhea" id="RHEA-COMP:9787"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
            <dbReference type="EC" id="1.14.11.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the JHDM1 histone demethylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.27" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462411.1">
        <property type="nucleotide sequence ID" value="XM_025606723.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317V5B6"/>
    <dbReference type="GeneID" id="37108866"/>
    <dbReference type="OrthoDB" id="5876800at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140680">
        <property type="term" value="F:histone H3K36me/H3K36me2 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041070">
        <property type="entry name" value="JHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050690">
        <property type="entry name" value="JHDM1_Histone_Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23123">
        <property type="entry name" value="PHD/F-BOX CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17811">
        <property type="entry name" value="JHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="21">
        <location>
            <begin position="326"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="22">
        <location>
            <begin position="583"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="11"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="103"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="886"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1081"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1125"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="902"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="946"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1160"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1230"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1255"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1273"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1302"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1340"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PWY69206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1424" mass="157594" checksum="70CCE96D9048AC38" modified="2018-10-10" version="1">MITATSFLNHLGSRPPRYRTPSPPRRAVEPISPCSTSDLRASWVDCNVFRVAASDRDHFLPNNAGYHHDDGTAAHRSSHGRSGSTIDALATIALATSPTFAPLSYRPPSQNSTPAMSLFPPEPIDSAERPTKRPRSEKDQSPFLQHRTVAVSDANSASLFDSMKTDAELLLNLARPTNFHPPASAAKRVSIDESFYHYGDEQKRNSMADSGGSSWRVNDEKYTYTTSGNPNLPPSRLRSQSDGSAAISRPVIQGVRPNTSSSTLPPILWQEEGDAGDDHWVLTTKSAVNGMPSGARSSIHATDITQMPTDQPSKVEDDTEFEDSSQASCAACNLVRIPIDTGEQGDVTWISCDGCKRWFHIVCAGFKNDREIRTVDKFICRGCRLVHGHTTFVRKSSRARTAIDYAGLNQGLVKAATDSLEHHYIEPIRQGKIQFLPERFPRMRPELVTAEYFERGNGMTEPIVIPAEWNTRESVWLNDSKLDALAQEAPTQEMFDEFLEHLVEEEKDHESVVDCGQDQLDMVIPQGLTVRRVAELYGPEERVEVIDVKSQQGEDKRWTMQKWADYYESTGDKVVRNVISLEVSQSPLGRLIRRPKVVRDLDLQDSVWPDELKAVGDYPKVQFYCLMSVADCYTDFHIDFGGSSVYYHILKGKKTFFFIPPKDKHLKKYEEWCNSPAQDSTFLGDQTKECYRVDLSEGDTMLIPSGWIHAVWTPENSLVIGGNFLTRLNYGMQIKIAQIEKDTKVARKFRYPFFQKIQWYTALRYLEDDPLPESVLEAFAQDENHRFHRGYPIYYEFGDRANHAPAGSPYHNSRFYSQAELEGLPDLAKYLLRTALIAGSYLVEGVTMDVRNAVRRSIPKVLGDPVDTVRKFGIWVAWKRGNERAPHWTRPGVIESNAKLSLTEKKPAGRPSRRSERNADSQRTYAERQAVQRLPEQPRDSPTELNNHSNSSVPSSSGAAMPDSSGSGAKEEAAPKPRSAPRGSGLGPKRVACDACRKRRIRCHHKDEHSDGLSGKQTAVAAFATGNHSLAHDAASALNSLAAIASEAGFQDNGSGRNPDRFEVSGKFNSAILSTPRAPVNGLGLNDASPEGANTGKKGRSKACDDCRKSKRRCIHDEYGRIDPVKAQERAKPRAAASAKRPRTNEEGVGSMHSKRMKQESTSPTSRPAHLSNSREGGVPETQDARLSDHAHSAVDFQAPFADAPQVDQVFPRQSDMTVEEKEAALGPTSYASPPSFQTDAVDAKEIDSAPVSKPTATLVSPPTSLADETDVPQDHVDGEGDHAMVLHTPTSSSRHSSRQPRQVDRYVPEVHVPKLVRAPTHTPTARRSSFGGSSGGARKSTPGPFSGSKKSSSRPSSSSHAKKSFWSTDERKGERQATSSTSPGQPGKNPKRVADEEPDAESLRLIRELQEAEFGLRKRSTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5P3</accession>
    <name>A0A317V5P3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sterigmatocystin 8-O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_539961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462441.1">
        <property type="nucleotide sequence ID" value="XM_025612807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5P3"/>
    <dbReference type="GeneID" id="37114950"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF11">
        <property type="entry name" value="O-METHYLTRANSFERASE (AFU_ORTHOLOGUE AFUA_2G17820)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="6">
        <location>
            <begin position="57"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="235"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY69613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="369" mass="40985" checksum="2F5E19A44D5EE325" modified="2018-10-10" version="1" fragment="single">MSATDFINLINSVTTSGQLDNLDDQQRAEISKACNKLQEQCESPQEKTLKILLSGHQAMVLRVAIDLKLFDAVIHRSTEKESRTVTVAQIAADTKADPALISRIMRFLSTMTIVTQHTSTTFTPTPSTKCYISTSHLSAAVIHFTHFHAILTHLPTYFSQNNYTNPTSPTNTPFQFALGTKSNYFDYLSTQPYYQTAFNTVMSSPFRRPSTPWFSLLPNTHPIFTPSPSPTKPVLLVDIGGGSQALDLQSFHNSHPHLPGRLILQDLPHVISSPTSPNPLPGYIEPQGYDFFTPQPIRGAKAYMLRTVLHDWPDIQAEIILRRVKDAMDKDSVLFIVEKVIPETGVGLHTAVGDWSMMVSFAGGERTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6Z8</accession>
    <name>A0A317V6Z8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_293786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462574.1">
        <property type="nucleotide sequence ID" value="XM_025606700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6Z8"/>
    <dbReference type="GeneID" id="37108843"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="234" mass="25514" checksum="D62450F7968F1569" modified="2018-10-10" version="1">MPAIDAAAAPPVSPRTGAIPTAIQEPPALNDAVSLGLVVVRTLTGLCPLQKRLAFEAGIAMGAVPLLIGSCPWPHSPATLRCATHPPCHPLVLGPVTCLDFEVSLKIKHRSPGCNHDVHMSCLEGLNLLQRHATSRNNWALCQHLHQSFFLVPEVVPTLSGRPNSRYCIQHSTLNPSLRQLPGRPLTLQSTPRPGLLYTAQVHFVDRNTRCYLVEMPRPLSDNHMGCISCNFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V935</accession>
    <name>A0A317V935_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_590194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462777.1">
        <property type="nucleotide sequence ID" value="XM_025616003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V935"/>
    <dbReference type="STRING" id="1450535.A0A317V935"/>
    <dbReference type="GeneID" id="37118146"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="406"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="949"/>
            <end position="990"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY70883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1086" mass="122513" checksum="C032005E55C80E73" modified="2018-10-10" version="1">MSDPDQYTVGWICALETEYVAARAFLEKKHPRPETLSPNDNNHYTLGEIAGHQVVIAVLPDGEYGISSAAGVARDMVHSFPNIRFGLMVGIGGGVPTKHDIRLGDVIVSSSRNGRGGLLQYDLGKELQGQEFYQTGFLNQPPPILRTAVAGLQAQYEKEGHQLKESVQAVLEGNNRLKRRYMQPPFEADRLFESQFAHLNPHANCGEICDSSKLIYRPKRTDEEDDPAIHYGLIASGNRVIEDTIFRDKLAADKDVLCFEMEAAGLMNHFPCLVIRGVCNYADSHKSKEWQGWAVMMAAAYARDLLYQIVPQRVKVERKAREVLDGIKSQLANVSKDIHNLRSITSGSAQEIHALSESIDLKELPVATGAEFGTYMDQHEEECLPGTRKELLLDIRDWAVSDQGKCIFWLNGLAGTGKSTISRTVAKDLREQGLLGASFSFKRGEGDRGNAARFFPTVIQQLFTRILELRAAILQAIRDNPRISTKPLKEQFEELIHKPLRSLIQSKLQSSRLVIVIDALDECDDDKDIEVILQLLPRVQEVNSLCLRFFITSRPELPLRLGFNAIDHRDLILHEVPKPIIERDISMFLKEKLVSIRHKRSLSSDWPGYVNVQILVNMSVPLFIFAATICRLFEDYNLDPAQCLTEILKYQNHESKLDGTYLPVLDRLVSKYNGTTQKQLIQGVREVVGTIILLESPLSFTSLSKLMGISTQSIHARLNSLHSVLYIPNNDILPVRLFHQSFRDFLLDPSTRGKSPFWVDEKGMNQTIFISCLSVMREDLKKNICSLGSYGTKRSDINLKSIDHYLLPELQYSCRYWIHHLARSKDPMSQVNDILTFLKEHFLHWLESMSILGITSEAIIAVNSLLQLTKWEIQDTSSNEMYDFLLDARRFILKFAQIVDTAPLQLYSSGLIFAPHRSLIRETFERELPAWLSKGPKVEEYWDPEMQTLEGHSRTVTSVAFSGDGQLLASGSDDITIKLWDAATGALKHNIITINIATDVQFLEHLPLLITNIGSLDIRNYYESFSISSEKVMEISLVAGRWVAVQGQRELWLSPNYQPRSSTVKNSTIALGSMSGRVAMIAFSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9V4</accession>
    <name>A0A317V9V4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_539985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462480.1">
        <property type="nucleotide sequence ID" value="XM_025612814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9V4"/>
    <dbReference type="STRING" id="1450535.A0A317V9V4"/>
    <dbReference type="GeneID" id="37114957"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY69652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="611" mass="65429" checksum="879B5585DD5E0058" modified="2018-10-10" version="1">MSVSEADIIIIGGGTAGLALAARLTENPNLQVLVLEAGQDQTDDPRVQTPALWPGLVATDSDWKFMTAPQVALGGKQIPLPQGRILGGSSAMNGMAFIANSKANIDAWGALGNTGWDWDTLSPYYRKTFTLTLPSEDKRQELGLEYVDKSVNGTDGPIQASFPDAVLDPIANAWVESLRGLGYPMSTDPFSGVAYGGYTNAATIDPVKKTRSFSANVYYLPAKDRTNLHVVTGALVQKVLLEVVPDGDAKATGVKYAKDNSVFTVTALREVILCAGAFNSPKLLELSGIGSRTILESFNLPVIIDNPSVGENLQDHVLAGLSFEVEDFINTKDDLMRRVPEVLGAAMESYHARQFGPFTIGGNYSSALLPLPDFSDPTTGSDELATVLATTVPDSSDPFAADLASFVRSLLENPREATGGYFTYPAQSDFKGSGAAMRTIQSKLPENYITICVSLMHPLSRGTCHISSADPADHPIIDPRYLTHPADLEMLARHTRFIDAIAASQPLASKLKPGGKRLGSPDDLRKISLDDVKEYVKCAGKSTFHPTSTCAMMPREKGGVVDSRLRVWGTNGLRIVDASVIPIVPRGNTQSAVYAIAERAADLIKEDLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VA04</accession>
    <name>A0A317VA04_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10 13">Catalase</fullName>
            <ecNumber evidence="3 10 13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_550766</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="3 10 13"/>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462566.1">
        <property type="nucleotide sequence ID" value="XM_025613507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VA04"/>
    <dbReference type="STRING" id="1450535.A0A317VA04"/>
    <dbReference type="GeneID" id="37115650"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03132">
        <property type="entry name" value="GATase1_catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000003">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024712">
        <property type="entry name" value="Catalase_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043156">
        <property type="entry name" value="Catalase_clade2_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041399">
        <property type="entry name" value="Catalase_large_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42821:SF1">
        <property type="entry name" value="CATALASE-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18011">
        <property type="entry name" value="Catalase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038927">
        <property type="entry name" value="Catalase_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 10 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 10 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="16">
        <location>
            <begin position="22"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038927-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY69868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="716" mass="80605" checksum="13E23E3E713E43EB" modified="2018-10-10" version="1">MDAKQADLARDTVQVSGAQPMTTDYGIKISDPDHWLRVVDGQHNGPSLLEDPIAREKIMRFDHERIPERVVHARGAGAFGTFKLHKAIPELSSAGVLTDTARETPVFVRFSTVQGSRGSADTVRDVRGFAIKMYTSEGNWDIVGNNIPVFFIQDAIKFPDVIHSVKPEPHNEIPQGQSAHNNFWDFQYMHSETTHMQQWIMSDRAIPRSYRMMQGFGVNTYCLVNAQGQRHFVKFIFTPELGVHSLVWDEALKIAGQDPDFHRKDLMDAIEAGQFPRWKFGIQVIPEEKKNDFEFDIQDATKIWPEELVPIQYIGQLELNRNVDEYFPQTEQVAFCTSHIVPGIDFSDDPLLVGRNFSYFDTQISRLGPNWQELPINRPVCPYMSLANRDGAMKHRITKGKVNYWPNRFDANPPTSPEQGGFATYPEKQQGVKARALSDKFKEHFNQAQLFYNSLSPIEKLHVSKAFSFELDHCDEEIVYKRLSERLAIVDLELAKTVAKNVGGDTPTKAPKDNNGKTSKGLSQLEYLSNSAQIATRRVAILIADGFDLDSYKGMKSALQKQNAFVFTIGSQRQGVTSESGEKVVPDHHFPGMRSTLFDATFIPGGKHIAVLAKNGIAKFWITESFAHLKPIAGVNEAVDFIRKQINLEAIKYASSGQVTESYGVVTAHGTPSDLLHASSKIGPESKGFLDQFIWQISRHRNWPRELEGLVDEIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VA54</accession>
    <name>A0A317VA54_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_569416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462861.1">
        <property type="nucleotide sequence ID" value="XM_025614736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VA54"/>
    <dbReference type="STRING" id="1450535.A0A317VA54"/>
    <dbReference type="GeneID" id="37116879"/>
    <dbReference type="OrthoDB" id="5337545at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY71106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="351" mass="37335" checksum="73647CF62844460B" modified="2018-10-10" version="1">MSNNEKRGSDDKPAKTHRNDANSSPGTNERPNSPSLASRIQNSASGLARNVFSTPGSSADTAQLLANSGKAGNSSSHSALAAAQQYRESSTSASPSTRESSISTPAETFRSSSTVRTGGFDLPPLTEDEFQRTYGMESFSSNNDSFISGLNADESKGKGKGRATDSDSTNPVTSDQRALPDQPSLLSSDGDAVVSLLSDHTFDPEFPPTADEPAEIVETELSPVQLTPTEIQMIESFRRLTPPAASATPQDTSARNLTSLSLVPDIGDFLATVPSGGNSDAATLRDNVLTGLPGAADWLTVEERYHDEVWGYLRPTLEAAAKEMESNNNTGRAEEGPAVRRLKMILKHMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VB14</accession>
    <name>A0A317VB14_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 45</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_539493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462941.1">
        <property type="nucleotide sequence ID" value="XM_025612712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VB14"/>
    <dbReference type="STRING" id="1450535.A0A317VB14"/>
    <dbReference type="GeneID" id="37114855"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.830.10:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY71543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="586" mass="66086" checksum="E2BD748B83548654" modified="2018-10-10" version="1">MVTAGDPSTTTGSSASSSSSAKMKILLLDSETVPIVSTAITQSALLNHEVYLIDRLDNAARERMRHLRCLCFVRPSPTSIQFLIDELREPKYGEYYIYLTNIIRKSSLERLAEADSHEVVRVVQEHFADFLVINPDLCSMNLGFPQQRLWSQSPDLWNADALQRATEGVIAMLLALKKNPLIRYEKNSLLAKKLATEVRYQLTQEEQLFNFRKTDTPPILLILDRRDDPITPLLTQWTYQAMVHELMGIHNGRVDLRDVPEIRPELREIVLSQDQDPFFKKNMYQNFGDLGQNIKEYVEQYQVKTQNTMNIESISDMKRFVEDYPEFRKLSGNVSKHVTLVGELSRRVGEEDLLDVSELEQSLACNDNHANDLKNLQRIVQLSNVPAENKLRLVALYAIRYEKQPNNALPILLDLMVTAGNVPSYKVNIIPKLLAYHHSLQAPPVAGGFSDLFESTSLFSGARDRFKGLKGVENVYTQHSPRLEATVQNLIKGRLRELQYPFLEGGGHTRDKPQDIIIFMVGGATYEEAKMVAQVNASSPGVRVVLGGTSIHNSTSFLEEVDDAVSGWPEPNPSSAAGRLQRAIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBR2</accession>
    <name>A0A317VBR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">glutathione-specific gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_526941</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.7" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462683.1">
        <property type="nucleotide sequence ID" value="XM_025610369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBR2"/>
    <dbReference type="STRING" id="1450535.A0A317VBR2"/>
    <dbReference type="GeneID" id="37112512"/>
    <dbReference type="OrthoDB" id="1933483at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061928">
        <property type="term" value="F:glutathione specific gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006840">
        <property type="entry name" value="ChaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192">
        <property type="entry name" value="CATION TRANSPORT PROTEIN CHAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12192:SF2">
        <property type="entry name" value="GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04752">
        <property type="entry name" value="ChaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY70392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="262" mass="29862" checksum="D570C13B4C603CFA" modified="2018-10-10" version="1">MVSSEGTPAVSSEKNWRENFPDGDLWVFGYGSLIWKPPPHFDQRVPGYINGYVRRFWQASNDHRGTPEKPGRVVTVIEREFWETLDDPLAHHETSPSATIWGAAYHIPASHANEVRHYLDIREINGYTDHYTPFHPVLKSQGSDATEFPTTPITCMVYIGQPTNSQFLREPAQREQQAVAEVISRSEGKSGKNAEYLFMLEKALEGLGLGNAEMHITDLVRRVKALQNEDEVRREEEKAERVLEESLHPSEQEAHWGFPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCT8</accession>
    <name>A0A317VCT8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_550593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462781.1">
        <property type="nucleotide sequence ID" value="XM_025613500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCT8"/>
    <dbReference type="STRING" id="1450535.A0A317VCT8"/>
    <dbReference type="GeneID" id="37115643"/>
    <dbReference type="OrthoDB" id="4509994at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY70887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16918" checksum="4856BD8AF32408C1" modified="2018-10-10" version="1">MEVGDKFDTFISNFHYLAIEAGIGEEDWKEDLYDRLLPELQECTIYCFSNREATFDDCVKACASTAELSEDRVEQHSTILTTTQTSRDTTRGTYTLIGSPSKPSTRASGMEPEVRERLMREGRCFYCKEAGHLSKVCPKKISLQLKALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCU6</accession>
    <name>A0A317VCU6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Senescence-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_476945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCU6"/>
    <dbReference type="OrthoDB" id="4378137at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052997">
        <property type="entry name" value="RRT15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047">
        <property type="entry name" value="PROTEIN TAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33047:SF8">
        <property type="entry name" value="REGULATOR OF RDNA TRANSCRIPTION PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY70897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17381" checksum="28A641A398D866D8" modified="2018-10-10" version="1">MIGRADIEGSKSNVAMNAWLPQASYPCGNFSGTSSLKFRGTKGSIGHTFMVCIHTENQNQGDFYPFVLLEISVLHESPLGHLRCGLTDVPPQPNSPPDNVFNPDRPAKDLNARRWAVKPMVFHWRRSSHLFYTPYVFSQCQTRVKLNRVFFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDP0</accession>
    <name>A0A317VDP0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_539671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462883.1">
        <property type="nucleotide sequence ID" value="XM_025612750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDP0"/>
    <dbReference type="GeneID" id="37114893"/>
    <dbReference type="OrthoDB" id="440424at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06140">
        <property type="entry name" value="Ifi-6-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016433523" evidence="6">
        <location>
            <begin position="23"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY71128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="189" mass="20279" checksum="EA5323E82D7C49B5" modified="2018-10-10" version="1">MRLAALLYVLVHLLALTSAAMAGFMGSAYIQAAERLQQLTAHLAPDSVRLNLSQLTNRTARLVDAHKPQIVRLASQAGNATKDYVGKHPVQCAFSVVTFFYPVGILRVVGYGPLGPHARSIAAWTQTYGGNPAAGSLRAYLQSAAMNGYGVSTVYNTIRGLVLSAGGYQAWREASGEGEKIDREKNDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VF60</accession>
    <name>A0A317VF60_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_539535</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462980.1">
        <property type="nucleotide sequence ID" value="XM_025612719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VF60"/>
    <dbReference type="STRING" id="1450535.A0A317VF60"/>
    <dbReference type="GeneID" id="37114862"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY71582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="45380" checksum="5B4119A110C37ED4" modified="2018-10-10" version="1">MDPAVEESVKRFAKDIYEYWKSRRTSGGSDPLLPTPKIEAGRDTDDTDPYVCFRRREVRQTRKTRGRDAQSADKLRRLRKELEDARQMVALVRQRELARKEMLAIERQVFMQRSEVKEMKRKLNIKDDDEDLINQKPKKKPAEAPAVQRPAAPQLRMPPKAGTQAAEDLQLLEDVQAEKENEILRDIKQNITKHIKWNEGYVDFTRAPLSPSPDRMFDSAFRPAITTQLPTPPSSDSSENLLESALDTTSAIALRDKLAPHAMELSEDTSQMPSFRRRIGRGGRLWIDRRKLASRCRVEMDPWKADRFKYDQEDSDDDLDFDRDQYDIQIMQHRAIMAAKARDQQAAAAAQAHAQAQAAQAQAQARRLQAEQTSATNPPSGGQTMGSNPGPGAIASTSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFC0</accession>
    <name>A0A317VFC0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_539283</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463112.1">
        <property type="nucleotide sequence ID" value="XM_025612672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFC0"/>
    <dbReference type="GeneID" id="37114815"/>
    <dbReference type="OrthoDB" id="3880401at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY72159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="227" mass="25173" checksum="8C13147EF4766120" modified="2018-10-10" version="1">MTSKIPENLYHVLLTTTHINKNPNNIIETLRIPGTYTSLLAAKAAAHSCLYDAGYERDFFPTYETSHAIFEKENLPDRLGLAIYAVAPDGTTFRVRIDTTPNKLQLTTDLDDGRVSIPLYYVVQANVEYDAIEGQSTVREVIVQSTFTEYLQGREYARSVLLSEQDGILKGSYAAYVEAGEEERDCGYGENVVVHASSDYGVNHLVSVIRNQELGSVILAEAAMRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VH15</accession>
    <name>A0A317VH15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_539132</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463231.1">
        <property type="nucleotide sequence ID" value="XM_025612636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VH15"/>
    <dbReference type="STRING" id="1450535.A0A317VH15"/>
    <dbReference type="GeneID" id="37114779"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000550">
        <property type="entry name" value="Serine/threonine kinase 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000374">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000728">
        <property type="entry name" value="Serine/threonine protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="32"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY72457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="424" mass="46863" checksum="95CA9FAC32AEC66E" modified="2018-10-10" version="1">MAQYFFDLLYNFTDCMCCFPSTPQLKINNRSFKLLRLLGEGGFSYVYLVQDKSTSELFALKKIRCPFGQESVSQALKEVEAYNLFTSQSNIIHSIDHCVSTESGSKFRADGGDAGSKTVYILLPYYQRGNLQDAINANLVNHARFPEKRLMVLMLGVANALRAMHLYRVRSGTGPTRKAKAIRREGAEADAEVAMRMGKPKRHGGQDMDEEEENEPLMDDEVTISQEGIQDGDLRPYAHRDIKPGNIMIADDGRTPILMDLGSLAPSPIAITSRSLALAVQDTAAEHSTMPYRAPELFDVKTGSIIDTKVDIWSLGCTLYACLVGKSPFEARSEETGGSLSMCVLGGDWRFPDEKSSGTKGKGKASDDNRKDNTMQISAPVKEVVRRCLQVEPADRPDIDELIQILKDVIKDLPEEDEIASGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHN2</accession>
    <name>A0A317VHN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_559868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463628.1">
        <property type="nucleotide sequence ID" value="XM_025614102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHN2"/>
    <dbReference type="STRING" id="1450535.A0A317VHN2"/>
    <dbReference type="GeneID" id="37116245"/>
    <dbReference type="OrthoDB" id="3533623at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="445" mass="49482" checksum="AB3BA3251EF57897" modified="2018-10-10" version="1">MARVEEPLDAPDGSALTWIFDHCLRYPGTYEIPLRTMYSLNCNPTRPPATGTRAPETAFHRPSNSSTSQDSLDPAADFRAQLTHQISRLPSQPCSLPPSFVTSFLRRCFTLQLEEVDFPQALTALDYLKDFENRRRKEVADALQRLGMEPNDVKEKSELARKYPGVLAWLESIGVQGRRLEALYTQIYVGLRRWTLINEMLMEPFNKANCIAMLNTLFPPVTDATVPPTSHLTPQILKSQRDGFFRYIAAVEANGPDVLTKVIAQGAPKGADNGWPLVREALDKYLRSANEIIDECTMVNGPNSVDEGIESQPRGHKGRKVDSGISFGSSDKLLSSPVDGSKGVEDVLEKPLPPPPSPKGATHKSGSTLERLAREIRKLGDAGKSRNLKKMRSTSALGARSENVVGRSMEENSLFEVDEQKRRRLLWEASTRKKAHAKQLSKDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHV8</accession>
    <name>A0A317VHV8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_538947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463655.1">
        <property type="nucleotide sequence ID" value="XM_025612594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHV8"/>
    <dbReference type="STRING" id="1450535.A0A317VHV8"/>
    <dbReference type="GeneID" id="37114737"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF24">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="123"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY73903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="405" mass="45358" checksum="283EA56CCC8A2E80" modified="2018-10-10" version="1">MVPKIVASPTGLILSALASSPCCQPVRLSPPVIRRSPLWSAHSGAPRTWVRRYRAVWPSYGITTPIPHPNPQFPISRSPFCFQTGYALCAKRPSRPFPPPFLSPPSSSFSDPLTTHYLSQDKRLSVRGDLVRGLNNGDDAVLVAENYLAVNDGVGAWATRPRGHAALWSRLLLHFWALEIERDPNGHSELDPIGYLQRAYEETIRATTSPGEWFGTTTSVTALLHWKHDDTGHVRPLLYITNLGDCKVFVIRPREKKILFRTQEQWHWFDCPMQLGTNSVDTPRKDAVLSLIDVQEDDLVVAVSDGILDNLWEHEILTVILESLEKWDQGRHDDKDMDWAPPAVLADEQMVFVARELLKSALAIAQDPFAESPYMEKAVDEGLAMQGGKMDDISVVVGCCKKKDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJG1</accession>
    <name>A0A317VJG1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_627338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463666.1">
        <property type="nucleotide sequence ID" value="XM_025617413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJG1"/>
    <dbReference type="STRING" id="1450535.A0A317VJG1"/>
    <dbReference type="GeneID" id="37119556"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42815:SF2">
        <property type="entry name" value="FAD-BINDING, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY74473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43074" checksum="ED0D5CDB51EC34A7" modified="2018-10-10" version="1">MSTSLQGWHPGELAIQRQLGYSTAVTNSWTFIKNFLPEQHRIFHTSNLPFLPITTIDEHGRPWASIVAGSTGEPGFINSPDPQTLSIHARLWTGDPLLNTITTWLNPKQQSTPPERYLTAGLGIEFSTRRRNKFAGRIEHVTTTTNTKLDYRIDVHVTEALGNCPKYINTRTLTPHPATNPTITHYHPHLPPSSLLPSEIISFIQSADTIFLATIYNPTSTPITTPHAGLNARSGLPGFTRIHPTTNQIIIPDYSGNRFVSTLGNIHASGLAGVTILSFTTGDVLYMTGTAEHYTGDAARKIMRGQGSLTAVRVTGYVFVRDAVPVREVVGTEVGRSMYSPKVKVLVQEDGLVMGGGGGVGYKALLERGELLGDGIGVFKFRIHSQGTGKGDGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNU3</accession>
    <name>A0A317VNU3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_229074</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463731.1">
        <property type="nucleotide sequence ID" value="XM_025606290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNU3"/>
    <dbReference type="STRING" id="1450535.A0A317VNU3"/>
    <dbReference type="GeneID" id="37108433"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="113"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="407"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY74538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="472" mass="53121" checksum="DB5D2EFB3C285BCC" modified="2018-10-10" version="1">MSSKSRWATDDDPETEAILAQRKRGKEEKRRAKAEKQRQLDEQQAQAQAQAQASASNSHPQDPDATAPPKKRRRLSNDHNQDQPTPTTTTNNESNILSFPTQEWGPCRNITNFERLNHIEEGSYGFVSRAKDITTGEVVALKKLKMDNSPDGFPVTGLREIQTLLEAQHQNIVYLREVVMGTKMDEVYLVMDFLEHDLKTLLDDMSEPFLPSEIKTILLQVLSGLDFLHDQWIMHRDLKTSNLLLNNRGEVKIADFGMARYYGDPPPKLTQLVVTLWYRSPELLLGAEKYSTEIDMWSIGCIFGELLTKEPLLQGKNEVEQVSKIFALTGPPTQQTWPEFRSLPNAKSLRLPPASSAPAGNPPLLPRAKFPFLTNAGLHLLSSLLALNPNARLSTKECLAHRYFREDPRPKPKEMFPTFPSKAGMEKRRRRETPEAPKRGQEAPKLDFASVFGGQSNADAGEQGAGFTLRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQY1</accession>
    <name>A0A317VQY1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_538599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463929.1">
        <property type="nucleotide sequence ID" value="XM_025612527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQY1"/>
    <dbReference type="STRING" id="1450535.A0A317VQY1"/>
    <dbReference type="GeneID" id="37114670"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004741">
        <property type="term" value="F:[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY75302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="422" mass="45758" checksum="607FB034491B46D7" modified="2018-10-10" version="1">MAYNTGSQNPGLDWKFQCMSVLDVKQATAKIKRNEASYKFQSGEIGTVSRIDTNQVPSNNPIEDHMATGKIDLGKGGIWHCWAIYDGHGGEQTAIVLSHALIPYVERALRAHFESSPETTIEDSIITAFNTLAEDISADGLAALESAHSHAEVQARLAPNYAGSCALLALYNPSESMLYVANTGDSRAVLGTPAESGSVHGTVVMSNDHAAANEAEVERLKALHPDQDDIITKRDGDCARYVGIAVTRAFGDARWNWPKEAMTKWEKEYSGKPAPGSVTNPPYLEATPEVKSYKLKGGEFLILASDGLWNHLTSEDAVEAVSKWVKVTKEGTLAEVGSGTPLAFGGEETSPDHAEGISYWDPWQVKPEWFVYEDDNAATHLVKNGLGGAQRQLFTGVLTVDTPVSRTMRDDVTVQVVFFDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VS77</accession>
    <name>A0A317VS77_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CBS and PB1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_499061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464242.1">
        <property type="nucleotide sequence ID" value="XM_025609360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VS77"/>
    <dbReference type="STRING" id="1450535.A0A317VS77"/>
    <dbReference type="GeneID" id="37111503"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06409">
        <property type="entry name" value="PB1_MUG70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="637"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="104"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="171"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="274"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="340"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="6">
        <location>
            <begin position="475"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="572"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="455"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY76429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="662" mass="71859" checksum="FC85661B438B73D1" modified="2018-10-10" version="1">MSSTPTFKGTISHKTVGRGRLPDFDSHIPRPRPETSSTTHTPQTASSDIGSSTMSAASSRQRQNQSKRDEAIRRKLEADLNKKRHVPARANRSRKAPPGTVLALKPSQALQIKPITSIAEAAQLMAAKREDCVLVTDDDDRIAGIFTAKDLAFRVVGAGLKAREITVAEIMTKNPLCARTDTSATDALDLMVRKGFRHLPVMDENQDISGVLDITKCFYDAMEKLERAYSSSRKLYDALEGVQTELGSSQPQQIIQYVEALRSKMSGPTLESVLDGMPPTTVSVRTTVRDAAALMKEHHTTALLVQDQGSITGIFTSKDIVLRVIAPGLDPATCSVVRVMTPHPDFAPSNMSIQAALRKMHDGHYLNLPVMNDAGEIVGMVDVLKLTYATLEQINTMQSHDDEGPAWNKFWLSMDHESDSMVSGSQQPAQRSVLSPESPKASYDARDSVLPNESASHHGGDEHSEYHVDSHHAEHIQFPFKFKAPSGRVHRVNVVPSAGIAELVAQVSAKLGPEVEAIGGSPNCDEGKLSNTGYALSYMDNEGDTVSITTDQDLADAVSLARKSNRDKVDLFVHDPTQPPIPATVEPQPAPSRPVEERSPVSEDQSEEEPLVTKPRAQSFPAHQPEEPFIAGVPNELLLPGAIVTLAAVIAGVFILSRATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUX1</accession>
    <name>A0A317VUX1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab GTPase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_588477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464688.1">
        <property type="nucleotide sequence ID" value="XM_025615886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUX1"/>
    <dbReference type="STRING" id="1450535.A0A317VUX1"/>
    <dbReference type="GeneID" id="37118029"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="189"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="372" mass="40366" checksum="2CD87909EE4546BA" modified="2018-10-10" version="1">MVRQRSLSNASSASSLPERNQELESMYDYLAKVILLGPSGAGKSCVLHRFVKSECMVVSDPLFTCPHIHTLLTSPGWMAGSLIRRSFVGRVLSSQTIGVEFSSKIVKLGTGPRRTRIKLQLWDTAGTERFRSVSRSYYRGAAGAILVYDITSHASFASLPTFLMDARALASPNLSVLLAGNKSDLASDALPGDIPDDSIRPPPTPSSTSSKRSFPFGSSGGSVRSITNFDTTTRMTATHALHGREVGTEETSRWAAKSNIPVAVEVSALTGEGVEELFNRLARIILTKIELGEIDPDDPQSGIQYGDGGLYGHGTSDGSSIRSRMSLDDGAVQMHRRHPKTNTSNNWKAGMREWEDVFRLSDSHQRRGSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW44</accession>
    <name>A0A317VW44_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-1,3-glucanase/mutanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_471802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464863.1">
        <property type="nucleotide sequence ID" value="XM_025608397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW44"/>
    <dbReference type="STRING" id="1450535.A0A317VW44"/>
    <dbReference type="GeneID" id="37110540"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016313055" evidence="1">
        <location>
            <begin position="20"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="502" mass="54602" checksum="F8E987FE16E033B4" modified="2018-10-10" version="1">MKLFQLVLALTGLLTLASCAPTSQNITAINSTTEATNRLVFCHFMIGITSNRQSAADYDNDMKQAKALGIDAFALNIGVDPYTDTQLNFAYESAARNDMKVFISFDFNWYNTGQAYAVGQKIRQYGSLPAQLKVDGKIFASSFAGDGLDINQMQSAAGAEVYFAPNFHPGTGNFNVIQGALNWMAWDNNGDNKAPSGGRNVSVSEGDKAYVNALGGKAYVAPASGWFFTHFGQEVSYSKNWVFPSDLLWYNRWFEILNLGPRFVEIVTWNDYGESHYIAPLASPHTDDGSSKWVMDMPHDGWLQMSKPFIAAYKNGDKSVDKYITEEKLIYWYRPTPKDVSCDNTDTTMDGNPNNSSGNFFRGRPNGWETMKDEVFVVSLLKSPGTIQVASGSNSQKFDAPAGATAFTVPMGVGQQKFALVRDGRTVLSDTSLKNIVNTCICGLYNFNAYVGTVPPPATVDKLGPAGLAALQQGLRAACPTNTLGVNMASVESTPVPTPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW96</accession>
    <name>A0A317VW96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_421453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464892.1">
        <property type="nucleotide sequence ID" value="XM_025607406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW96"/>
    <dbReference type="STRING" id="1450535.A0A317VW96"/>
    <dbReference type="GeneID" id="37109549"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY78583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="222" mass="24232" checksum="84AAE220A193E31B" modified="2018-10-10" version="1" fragment="single">INMAMSATTIAMSADSTSTSMAEASSNCQISMLWNWDTVGTCFITSSWHNTSPGMFAGSCIGTFCLVLILEFLRRATYEYDAFIVNRARLRVRFLAVGYGSSTTAIATPAPAPAPMTTEAPSPTTPSSCCYSRTNNIDCKGMTLPPPRTPPTPPSQSQPQNLTPMPFAHRPTFPEQIIRAILHTVQFAVAYLIMLLAMYFNGYIIFCIFIGTFSGFLVFGWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYU1</accession>
    <name>A0A317VYU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_497510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465096.1">
        <property type="nucleotide sequence ID" value="XM_025609319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYU1"/>
    <dbReference type="STRING" id="1450535.A0A317VYU1"/>
    <dbReference type="GeneID" id="37111462"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="584"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY79524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="839" mass="94711" checksum="F7320787C8308387" modified="2018-10-10" version="1" fragment="single">MATEDYIRALEQRLAQVESRLLGLENGNKTAGSDVPDSSADTASIASTEQAVKNDPQEKPASETEDSNNNPRPPLPPIELKVQNLSYIPFTYHALPADSQPLIEALYFPNGRKKAREERNTFYNTLESVKPDKAVQMIRDAYVPAGDFDMAHVAALRITSQPLGNILQSLWNAEPSMEHVLMYPPFNDPIYFFDGAKKKLAEMEAHAEQDPGPAPGDGPGTSSQTPSEPSLLEQLRFYVHLMEQEVIPFCEHFKTLSASDNATVQFDNLYHLFQPGDIIVYPGASTNHETGLGSNRGDQLLWRVYSRWGLSTSDQLVVNAYCIDYDGHSYVCSTQSFTIKRFDGAVSVTSLKVYPIRCASNMQSLLDDAKRRGEAFQRFTKTKLVTHNGWASEPNPSDPTLRYITGDVVIDFTETFKAHADCKPTTQLPDFDKSDTDKSSYTDQLLLFWTDGKALGESQEKWVWYSGEHPQTVEEKDYCYDEDNFLSYLFEGDQNEYTLSEEDLCLLPRRLFAYSLQDRRFVAVDVDNLKLIEYAQSKFDSLVINQKHERMLRALIQSHFSRKEIYDLTGNRITTQDIVHNKGRGLIILLHGVPGVGKTSTAETFANEFRKPLLPITCGDLGLDPATVEQSLKEMFRLAQLWDCVLLLDEADVFLTERIPSDLNRNALVSVFLRVLDYYAGVLFLTTNRVGTIDEAFKSRLHVSLYYPHLKPNQTEKIWQINLKRLGEIEAEQSRITGQPPMTVDYNGILEFARDHYRKGRDSGKGVWNGRQIRNAFLIASALARFEMGQGPDIPRSYDLSASHFKTVVEVGFGFEVYLQEVKGKSDGEAAFLQGTRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1M9</accession>
    <name>A0A317W1M9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/calcium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_548609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465083.1">
        <property type="nucleotide sequence ID" value="XM_025613411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1M9"/>
    <dbReference type="STRING" id="1450535.A0A317W1M9"/>
    <dbReference type="GeneID" id="37115554"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="288"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="192"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="412"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="50"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY79511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="565" mass="61690" checksum="0953236AED5FF00F" modified="2018-10-10" version="1">MHIYKRHARKLAWYDQEGEPSSHNPFKKFRRQPRRTNSIQLENRLTPIMSEGDMRLSEERRRRRDMTDGLVGPEHADSFPPQSAGTDMVARSENGDRVGTNPSMHSQVPINVPLQDEPGDMQGPRKRRTFMSNTLNPEDDRMTSDMDKPVAEKRKFTVMGQLKATIFNSWINILLVAAPVGIALNYVNVSPVAVFVVNFIAIIPLAAMLSYATEEIAMRTGETIGGLLNATFGNAVELIVAIIALVADEVTIVQTSLIGSMLSNLLLVMGMCFFFGGVDRLEQHFNPVVAQTAASLLALAVGSLIIPTAFHAWSDVPAGDAGVAPLSRGTSVILLVVYGCYLFFQLKSHTEIYNAPSPKVEKRRQKVNEGDASRGIAQIGKMSASMAGEYAQKVELQEPEDAEEPQLSVMVAVLTLVISTVFVALCAEFMVDSIDALTTQGHISETFVGLILLPIVGNAAEHATAVTVACKDKMDLAIGVAVGSSMQIALLVLPLIIVIGWGMGKDDMTLYFDAFQVILLFVAVLLVNYLIADGKSHWLEGVLLMMMYLIIAVAAWFYPSKTGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W272</accession>
    <name>A0A317W272_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Aldose 1-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_164360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464919.1">
        <property type="nucleotide sequence ID" value="XM_025605889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W272"/>
    <dbReference type="STRING" id="1450535.A0A317W272"/>
    <dbReference type="GeneID" id="37108032"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000015">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018052">
        <property type="entry name" value="Ald1_epimerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00545">
        <property type="entry name" value="ALDOSE_1_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY79347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="332" mass="37026" checksum="EB1BB60D9139D673" modified="2018-10-10" version="1">MGDKTSAKFSSLGAIIQEFNVDGQNIVQGFSTKELYEKHNSPWFGANIGRVANRIKDGVIRNLNGREYQLEKNDPPNALHGGSRGWGRCDFEGPTVLSRNGKNTLLYTYLSPHDEAGYPGTVELRVFYTTSEEVENGSTKSVLHIEYEAELVGDECEETVINLTNHSYFNIGGGATTEGTIAKLATQDYLPLESGIPLGPIEPYPSEVTKDFTFGPHNQFDDVFVMEREIARVPLDTRGEPLRLQAEFQHPDSRLHLQVHSTEPAFQFYTGQGIDVPETDRNPSRGPFAGFCIEPSRFVNAINEPAWRHTVVLKKGAKYGSTIVYKAWRGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W420</accession>
    <name>A0A317W420_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zf-PARP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_537221</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465210.1">
        <property type="nucleotide sequence ID" value="XM_025612221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W420"/>
    <dbReference type="STRING" id="1450535.A0A317W420"/>
    <dbReference type="GeneID" id="37114364"/>
    <dbReference type="OrthoDB" id="429950at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00645">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="98"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY80351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="358" mass="38624" checksum="79F572EA7EF78A6E" modified="2018-10-10" version="1">MGAYRLEQALTGRAGCKNKECKDQGLKIAKGELRHGSWIDNDKFQSYSWRHWGCVTPKIIANMIEAVDDASKSDEKDYTVLDGYEELSQEAQAKIRKALEQGHVDDEDWKGDVEMNRPGKSGFRKRASKKATDETPKKPTEEKTAPPSKKRARAEPKEEAASEADGAEAKETPKPKKPASEKPTPQSKKRARTVPKGEAELEADGDEAKETPKTKKPRKSSTPKPAPADNGETKEGESEGKSEGKSEEKSEEKSEEKSETKGKAEAEAEAEAEGEGSDAPLVKTTKKGTTTKGKRGKAASSPPAEPTRARSTRVREAAAKKEAAAASATSAASGSVDGEAEPAEKPKRTYKKKKAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W443</accession>
    <name>A0A317W443_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_537250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465240.1">
        <property type="nucleotide sequence ID" value="XM_025612227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W443"/>
    <dbReference type="STRING" id="1450535.A0A317W443"/>
    <dbReference type="GeneID" id="37114370"/>
    <dbReference type="OrthoDB" id="413885at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.10">
        <property type="entry name" value="Cholesterol Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053208">
        <property type="entry name" value="GMC_Oxidoreductase_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47190:SF4">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016456584" evidence="3">
        <location>
            <begin position="21"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY80381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="547" mass="58438" checksum="8663F93F982C3E8A" modified="2018-10-10" version="1">MRSFLLAGLVATSSAIGAAASRHAHASAQSDAYDYIVVGGGPSGIITAERLVEANKKVLLLERGYGPTVATGANDTLSWNSTLTPIDLPGLSADIGALPQWEEYICTDTAGYAACVLGGGVTVNYMVFVHPPDHDFDDKWPTGWKWDDVKSAADRLYERNPGTILPSADGKRYDQGLYTVLSNFFNKLGWKSVDMITQPNEKYEVYSYPAWNIKDQVRAGPVRTYLPLAEKSNNFDLRLGTKVLRLLRSGSQVTGVEVENSSGSRENITIADDGRVVLSAGALSTPRILFNSGIGPSSQIEIAEESGVTVPPKKDWINLPVGIGAKDHPIFSIIVKTNGTYGLPDYDAIVNGSDTTDISLYGKGSGLLTEGKHRMIFFTSNDIDDQTRYYQGSCAPTGTDLVTITAYMTHGLTSSGVLGLSSDGSTVWDKEPYLTTAGDVAAATAFIEQMVGDLTDSTGFTLETYTNVTQILGSVSPGMHYTTTAKMGTDDGRYGNGTSVVDTNTKVYGTDNLFIVDGSIHPDLPTGNIQATIMVVAEAAVARILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4J2</accession>
    <name>A0A317W4J2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">F-box domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_548209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465521.1">
        <property type="nucleotide sequence ID" value="XM_025613385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4J2"/>
    <dbReference type="STRING" id="1450535.A0A317W4J2"/>
    <dbReference type="GeneID" id="37115528"/>
    <dbReference type="OrthoDB" id="5376710at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14270">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1042" mass="115918" checksum="99976F809C1F1663" modified="2018-10-10" version="1">MASKAHHSEDEISDSAYVVDENIEEEEEEDDDDVSISPISERAPPWSGTRWARFFPELSSHFSLVSPTNSTTHLLSQSHMKGVPHVDSQLQPLEGVKGRSSLSSEEVADNRSSSYTSRSSLTSQGSEVTSPVHKPVDSFHMASSAGTSVFDESKSEQRIPRPLQKRPSIAQSKDKPLPQEPPIELTPLSIRHKTSQTLDRDLDHYARLNPPPRSILQPSYHHSTLSQATNDLERTLAGLTEQRQVPEPLSPRAPLQVFNGPLQISRGNMDMVATRPAPRPPANVHESQQIRKAKSREDTKQTKKPHKAKPPFSFTVPSFGRKLSRAHQRSTSNSSSKSEPESSRASVLHPPVVFELGNSEVAELQGSSIVASEGRPASAGGEKGRRMKLPRLQTKEMGTLRRESIMRPFNSTEGRVPNTRNHPEQQGRPCERARSASLNEKYFVSCSKSGETPAKITRQDKQVSGTSAMVYELEASLPLSPVELQGDATTPTCKSVGAMPTTLPVRVVLSILEQVNSLDELFNVAVLRRDFYRVFKQHELRLMRRAVFEMSAPAWELREMSPPWDTEWQTLLDPDAPVPEYTPACYLKRYAQDIYTLAHLKSLILARCGSFLRPETIRGLSGMDDDRATQIDDAFWRVWTFCRIFGSGKHREGDIVGQLDWLRGGTVAMSRCASVATSITDPYDANSVLFEPPVGFGYGNKGPLSKDQLHDMTEIWTCLGVLLQPMHGKCSEARAAGIFDGHDVAVNDPAKEAAILEEWTYYILTLGLSAVLILGSIHAYDNTAVVFQRAQSMGLTRWEPSDTGASRSTFLREAVSKAYQPQRSITSQTSSYSPCLNSQLSGSLVSREGSPTTNSPGERMPSPDFHRRRQAAYSAQIKHQRQQQQLSPPIVMPAEERPISQYATIMSRLEALPLAPQPPMSMSRMATSPTTHSYVSNVHYMQAPRLVMPVMPVYQPQVRDPVDRALDTMVRELGFEEEKAKWALKVTDNGEGINVNAAISLLVREQKSHGQSHRGFSLKKRRSFLSSVINSPESRYSGWKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4S6</accession>
    <name>A0A317W4S6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_537164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465146.1">
        <property type="nucleotide sequence ID" value="XM_025612204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4S6"/>
    <dbReference type="GeneID" id="37114347"/>
    <dbReference type="OrthoDB" id="4503624at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="117" mass="13351" checksum="8378802199C86329" modified="2018-10-10" version="1">MSRMQKGRILPPPLNRPSEDTTHSEGPNHHNPPDIEKYQSYAGHAHLDDDVDVDENDNDDWETLSGNSSSRDRRSVIVLCAACYVAFAILSFFSAAYYFWCLMPYEPSNSNPFPKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5D4</accession>
    <name>A0A317W5D4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_161522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465296.1">
        <property type="nucleotide sequence ID" value="XM_025605870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5D4"/>
    <dbReference type="STRING" id="1450535.A0A317W5D4"/>
    <dbReference type="GeneID" id="37108013"/>
    <dbReference type="OrthoDB" id="3548481at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09276">
        <property type="entry name" value="Rnase_HI_RT_non_LTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="222"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY80437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="395" mass="43750" checksum="52733B5C06A0744E" modified="2018-10-10" version="1">MEAQMPAEVASINWNNVKPQIVKGKVADFTLEDAGVQRVEDGARGSPMIDRDYILDRVQSKSSNDKIRDSHTDKVKGAAAFVLGKREHRSASTSSASSNSNSNSNSNESSRDSHTDLIRVQGDAPSPVSDDAAPIEAKASKKRRGKKHAQKQNKRQQQPQQQPQQQPQQQPQQQPQQQQGKQHQEQFQPSIQTYQDSRFDRVQAVRPHAGAITYAVENEKSSNNRHVFWVDGSTAADQIAPSGAAIVWDKLQGGDLAELMYVVDDARLSQQGELFAIGAGLKAAVHRLERLEASGHTVRVFTDCMSAMTMLRPDSKKPNPLADRLVDLIDALSYRLSTMGVKIEIHWVPGHENIEGHKRADLSSRTITKFLTLGLGHQLHKLPAHRVDCAFLELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W5E8</accession>
    <name>A0A317W5E8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_150245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465423.1">
        <property type="nucleotide sequence ID" value="XM_025605795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W5E8"/>
    <dbReference type="STRING" id="1450535.A0A317W5E8"/>
    <dbReference type="GeneID" id="37107938"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF1">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="67"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY80821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="611" mass="66075" checksum="8F721B875A2508E0" modified="2018-10-10" version="1">MTFPKNGLVIGAITVAVAFLATYLVPFTDIFLEKAVELGVTLPKGFVPPPIVHDTGRDIKYIGSLSNEVEHFQNIFYAEEPTGSRRFAPPVPVQPPAGTVIDATSPGAWCPQGTGDILPFTSRVSNISENCLSLRIARPTGLKDERLPVVVWLHGGGHALGSASEVLYNPEGLVKEAVVAGKPLIYVAINYRLGLFGFATSEAMVENKQTNAGLRDQRAALEWVRDNIEAFGGDPDRVTAIGQSVGASDIGLHLTSWSGTKGVPFQQAIMMSGAPGLNFNSDPALVADNTASVAKEVGCVTKDAQSLETLDCIRRIPFETLTNISVTASRAARPPFGEGFFYPTIDGDILPGRPTELLRAGKFVKDVPIIASWVTNDGAWYAPPPTSTDEEVLGSFGLWLSKLSPLTKEKLLDLYPVAAFEHMAGEGPISPQYYRAAQLNRDIWFSCPVLDFTWQYVQKGGVDASKVWLYEHNATRYAPVFEMMGVPMWRVAHLSDIPYVMNNGNVGGGADNSPEQMELSQLVSRRVIGFAHDGRPGEEWPAAFLGGSEELPKESPGRVSIQVFGGPVPGPVTVRKDASDATAAEQAVLWEKLFDRCEFINSVQMRAEAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W603</accession>
    <name>A0A317W603_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_144526</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465587.1">
        <property type="nucleotide sequence ID" value="XM_025605747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W603"/>
    <dbReference type="STRING" id="1450535.A0A317W603"/>
    <dbReference type="GeneID" id="37107890"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="58"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="11">
        <location>
            <begin position="240"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY81519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="392" mass="42152" checksum="0B53EE4C23EAABB3" modified="2018-10-10" version="1">MNFKMAFVESAREMGRPSPLANLWHIIEVTLFSSYTNVLLVFVFLGILSGSQEWNPSAVFILNFLAIFPLASLLSFATEELAKSVGQTVGGLINASFGNAIEMIVGITAVTQGEIHIVQSSMVGSILSGTLLVLGCCFFASGYNKETVLFNVDVTGIMSSLMIVSSAALIIPSTLYSTALYASPNGSEYILRLSHITAVFLLIFYFVYLYFQLSSHAHLFSGTEDDDQEERQLGPIAASLVLVLATLGVTVCSDYLVDGVDGFVEAYGVSRAFLGLIVVPIVGNAGEFATTVKAAKEGKVDLAIGVIVGSTLQIALFVTPFLVLYGWALGEPMSLRFNTFETACFSLAVVVMNCLIREGRSNYFAGVLLCGTYLIIAIAFYVHPDIVAPSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9N5</accession>
    <name>A0A317W9N5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_469249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466099.1">
        <property type="nucleotide sequence ID" value="XM_025608286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9N5"/>
    <dbReference type="STRING" id="1450535.A0A317W9N5"/>
    <dbReference type="GeneID" id="37110429"/>
    <dbReference type="OrthoDB" id="435520at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="539"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="903" mass="98514" checksum="466CFF96BEE438FB" modified="2018-10-10" version="1">MDRVEDPLASKVDAPFQPSPLVPRHHKSIPSRSHPTDPSTTVDPASPEVISSLISSLSTISVPLQSHFDNVPRIGSETAPSAPVYILSGQHFSPDQHQLSEHGFGVSNRARQASEEALQTPFLHPDDAAAPPVIRMARAPPSPKSKATLDPPLSPGRPTSRGSYTSSKAAYEDSAFGTITTEPGPRVSTANSVASSGSRKSLRNQFNLLKRPSREFCGDKDRPTDRLRKTSSFNDGLRHNIPRSRASIRSLCSMADVAEETRPVRSATEPTREATFSRPSSKERHSLQNARDSAPNTPGGIGSGRIIPARESSLRHSFYSSPKHRRSARHSRYSSTSSREMKMDSAVSAMGNEAEQVTKRIQELKDQQQKIKSELEIDDTPDKPSKFAPVAPVRQPQQIRDSGESIGHGQVARQGDCAFDESAPAPAVMTGKSRFITRNDPPLASKFTNTLPQSLDKLDPLARYRGPLEQSAPALSHRRSPSDSAAPVSTGEDRPSSADSIDLAVYDYILSPKLTQRVSHPTSGRAIAFSEVGDPKGYVVLCCLGMGLTRYLMAFYDELARSLRLRLITLDRPGVGESGPYVDEPGTPLNWPDDVAIVCNHLKVTKFSIMAHSAGAIYALATALRIPQHIRGRIHLLAPWIPPSQLSSIGSQKAPVPTNAVPYSQRILRALPTSILKVANSSFMSATSASLTSSLPKSPRRAKRKAMLKDTSGSTGPEAKGTQRLTSKVYQQGADFKALEGLKAPDISVGESYHRAAEPTKSEVLLASSQERERQTDYDNRLTHKIWELATTNANPAVDLLVCLERRQPIGFRYVDITRNVVIHHGSRDTRVPVDNVRWLGQTMRRCEVRVLEGEGHGLMASAAVMGNVLMEIAKEWDDWMIVVQGKRRATVGTRTGIAVQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WB01</accession>
    <name>A0A317WB01_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PEX11 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_449279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466142.1">
        <property type="nucleotide sequence ID" value="XM_025607533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WB01"/>
    <dbReference type="GeneID" id="37109676"/>
    <dbReference type="OrthoDB" id="3636394at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF23">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11B (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY83674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25840" checksum="0D8566D8532B033D" modified="2018-10-10" version="1" fragment="single">MLTHLSRFTRTTPGLEKTLRLVQSLCVLALQVPDLNYVAVTRFGIAKQQLALTRRFLRFFNFIECFNRVFALLAAPTASTARQGGSGSGSGMVIQVLEITKWSCFGCYFLLEDLTLLHATSIHPLPTPLNKFILTEANKFWFYALSFSLLGAGVSFLSSFTFSSSSTVFESVKTEKKTKTAAGSITWYGIFKMAVVDSCDLLIPGTFLGWIQMEQVGVGVGMVVSTLVSGWEIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDM6</accession>
    <name>A0A317WDM6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_519435</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466299.1">
        <property type="nucleotide sequence ID" value="XM_025610071.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WDM6"/>
    <dbReference type="GeneID" id="37112214"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="17"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="960"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2512"/>
            <end position="2589"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="960"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1129"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="992"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY83831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2594" mass="283084" checksum="A6EBD0EA9A81589C" modified="2018-10-10" version="1">MLKTSTLEKLRLPTTTMDDIAIVGLSIKFPGDAETAESFWSMLLEKQCAMEEWPKDRFNLEAFANPKSKGFVSGAHFMKEDCGLFDASFFGVSGTEACAMDPQARLLLEAAYRALENGITSIGQSSGMPIEKLSGSKTAVFNGCMADDYRHIITHDPDFMPKYTAVGSTACMLANRLSWFFNFRGPSVNLDSACSSSLMALDLACQSLRNGDSDMALVTGCNIIIGIEPIVSLIKMGFTSPDGRCFSFDARANGYGRGEGVGVVVIKRVGDAIRDGDTIRAVIRSTGSNQDGHTPGLTQPSKDAQAHLILDTYEKAGLDLSLTRYFEAHGTGTAIGDPIEAEAVGSVFRTLRSPEDPLYIGAVKSNIGHLEGGSGIAGIVKAVMVLENGLIPPNANFEHLNPNIDAEFYNLRIPTEIIPWPSQGLRRASVASFGFGGSNSHAILEDAYHYLQQRGISRAHCLPPAPSNPAAVIFLLSADDEGGIQRLVAAYTAFFKSLTLEKRDEQPFLKQLARTLTTRRSQLKWKAFAVADSLATLQNIQAVISQPVRAGSSLGLGYIFTGQGAQYYRMGVELLCFPAFRETMEHCQRAFHSFGCSWSILERLNGVESEFDISDPEYAQPMTTALQISLVELLTSMGMKPRIVIGHSSGEIAAAYATGGLSLESACKVSYYRGALASRLRRADGSGAMLAVNLSETAVEPYLDRVTSAMPGQAISISCINSPSNVTISGHSEAIDRLKSILEAEQILSHRLRTGVAYHSPQMEQVAAEYEQALTDLTMQEKGLAQTTSMISSVTGQTVDGLGVLSTGTYWVDNMTQPVRFSAAMANALSGSAKKEQRHKRLGASKKHIISDWLEIGPHCALKRPFCQLVESSEREREVRYCSILDRHLPAIASVQRTVGSLFVHGHSVLLEEVNQCQTDGTGFENLLTKLPEYPFNHTKRYWYEREATRNVRVRSHPKLDLIGVPTPESTPSQSKWRKVFDASDSPWLLDHAVNGKAIYPATGMIVMAIEGARQLADQGRPVAGYFLHDALFLNPISIRTIEPTETHLHMTPTRSRMDHSSHAYEFQIYSAAGDRWQLNCRGQISVQYQTTTDAVASTEGGSASLHLHSRREADYYEERWAAAQRECLISVSKDKIYTAFEGNGLQYGPSFQVLDDLHWDGCSTSIGYVTPFQWSMEESHSPSDPHVVHPATLDGLGQLGWVALTHGGQSSVTTGLVSTRVREAWISNAGASSSDTAALRAVAQSRFKGLRGTDTSVFALDSMGQLRLWISGMETTSMSGNNVQVLDSERRDLCYSLSWKPDPTFLTPQQLQSCCKAPREARHADLGRHLDRLLSSYVQKAVRAVSERRGTELPSHLREYVAWLDRMLEKSAPLSADTIPQDETEISALEGQVMKLSPLGNLYVTVSKQLDAILDGSTEPQSLLGSDDRLLTEYRRVLFSQLWEQNELTNYIDVLTHKSPQMRILEVGTGSGAMTQQILNSLSRRGEDGSETYRFAHYDCTGISNTHVEQAQARLGALGPRVTFKTLDVERDPAAQGFHVGSYDLVITAWLSHGTRHIGPSLHHIRRLLKPGGKLLLVESPGAYTLRDGFILGALVESWLADGSTPERNLDYPESNWSEALSAQGFNGLDALFRDDLGSCLMVATAGGAAEKNHSARPIVFVVHPDSRMQSHLVYLLMELGRERETGFDTCSIWDINTIDLCKSPLVVFLPELEQPLLVDLDGAMFSKLQHFLCKALDIVWITAASHGSPLSPETYVVDGLARTLCTENNRLSMVTVHLEDHRAQPQIWARHIDCILGDRLRANGKASELQYREQQGMLHIARVDAAEPLNEALFEQTQAPPRMRPLHPDTPWTCAITTPGSVDSTSMIFLEDLEVQDQPIGRDEIEIDVHSVGVNFRDVFVLLGKLNDGHSLGCECAGIVTRVGSACPDFQPGDRVCAVILGCLRTRARCNYRLAAKVPETISLAVACAIPLGGVTIHHSLVVVARLRPGESVLIHSGAGGTGQMAIQLAQSIGARVFVTVGSDEKRDLVKDLYGIPDEQVLFSRDTSFQRHIMRLTNNQGVDVVLNSLAGDGLVASWECIAPYGRFVELGKSDIQSNSSLSMIKFGRNVSFSAVAIDQMPEDRPALIQESLVPVMEMVRSGTLTHARPLQEFSIGAAVDAFRLMQSGRNTGKLVINLNSTDLVRTSLRHLPSYSFPAEATYVIAGGLGGLGRSAARWMASMGAKNLILLSRSGPQSVAAQALVRELTERGVEVRAPKCDATIPAALASALEHCNDLPPIRGCIQATMVLQDTIFESLTFDQWNTTLQSKVQSTQNLHTLLPTDLDFFILLSSLAGIIGTVSQANYAAGNTFQDAFAAYRRSLGQRAISLNLGWMREVGIVAEQEKYMSRVDKVSAMAQINENEFLGLLERCCDPAVNQGGPLDPRLSSTTSTLISTYPQILVGLITPAQLRAHGLEPPDWLLERSMFQSLPQDLPLDANLTLSADSSAASDTSTSAWHRALRQASSATAATTVVVEGLIQKLARALSLSPGEIDLQRSLALQGVDSLLAVELRQWVSRAFVAEVSALDVTSAASLEDLAALVVAASEIKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WER4</accession>
    <name>A0A317WER4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_586771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466185.1">
        <property type="nucleotide sequence ID" value="XM_025615777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WER4"/>
    <dbReference type="STRING" id="1450535.A0A317WER4"/>
    <dbReference type="GeneID" id="37117920"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31998" checksum="DA32BDF19386BC4C" modified="2018-10-10" version="1">MGLGKYMGVSKPENGRDSEDDSDLEGLLHDPQSGAVSRSPKARRWGLSSIFHWIAHAITIILILGLYVRSDPQRSTKLSIYSPLIEAIGDTSRIETFKGTLWQSSPYHGPPTDEVMAAWKHIAHIPLLNVTAEEMSRMGHSLDSVQYPPERGGGYVAQFEAIHQLHCLHSLWQDHHYQKHPEMFPELTEERNAFPDVAEEHYEHCVNMLRQRLMCTPDPNFVAWRWVEGVTGPYADFNTPHVCQDYEALLEWGRSRAVDADVVEDFYSWIPPADAVVLSQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WGR2</accession>
    <name>A0A317WGR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO94DRAFT_535780</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466671.1">
        <property type="nucleotide sequence ID" value="XM_025611862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WGR2"/>
    <dbReference type="STRING" id="1450535.A0A317WGR2"/>
    <dbReference type="GeneID" id="37114005"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07866">
        <property type="entry name" value="STKc_BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="25"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="355"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="518"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="536"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PWY85654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="550" mass="61861" checksum="8205A5EB70257F77" modified="2018-10-10" version="1">MVIVSLERDSNGNTRFRGCTSIRDFEFLGKLGEGTFGEVYKARSKKDNTVVALKKILMHNERDGFPITALREVKLLKMLSHTNILHLREMAVERSKGEGRKKPSMYMVTPYMEHDLSGLLENPAVHFTEAQIKCYMLQLLEGLRYLHENRILHRDMKAANLLISNRGILQIADFGLARPYEEPPPRPGKGGGEARRDYTTLVVTRWYRPPELLLQLRRYTTAIDMWGVGCVFGEMFKGRPILAGNSDLNQAQLIFNLVGSPTEESMPGWSSLPGCEGVKNFGNRPGNLGEIFKDQSPAAISLLSELLKLDWRKRINAMDALKHPYFFSPPLPARPGELPSFEDSHELDRRRFRGQRAPMPPAPAGGSIGTGGPNGSWAACSGNRTGIDGRNSRLPNAARGNWNHGAQGVPPQRSIDNRNCETHTARSRSGGEESGQGPWHKGGLPPRPPMSNHQAWASGNIGRVGRDRNHQGRGRSEGNLDSYIPNYTGGGDRHWERDHSSSNMDRRELTSDQAHQSMRRDYSRENFSRRRSRSPNFREGRDVARAFHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH25</accession>
    <name>A0A317WH25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RINT-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466487.1">
        <property type="nucleotide sequence ID" value="XM_025611943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH25"/>
    <dbReference type="STRING" id="1450535.A0A317WH25"/>
    <dbReference type="GeneID" id="37114086"/>
    <dbReference type="OrthoDB" id="2189254at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070939">
        <property type="term" value="C:Dsl1/NZR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060628">
        <property type="term" value="P:regulation of ER to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1420:FF:000001">
        <property type="entry name" value="RINT-1 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1420">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007528">
        <property type="entry name" value="RINT1_Tip20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042042">
        <property type="entry name" value="Tip20p_domB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520:SF0">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13520">
        <property type="entry name" value="RAD50-INTERACTING PROTEIN 1 RINT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04437">
        <property type="entry name" value="RINT1_TIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51386">
        <property type="entry name" value="RINT1_TIP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="759"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="816" mass="91137" checksum="D167E8060933909A" modified="2018-10-10" version="1">MATPASALSSHERTRVEDYLNDKLQVSADLDSLDSLLSSLRAQHELQRKQLAEAQEALSNATKASNDHAEATRKRAEAFGEQQADIDQRLKALTGSNSSDEAAKRFEASIEKLRRLEISRGYMTLLKEAEGLSKEALKNIKDQPQIAIQSYTRLRKIARSLTEAQPAAEGAAPHLVDYVGKLASALREHMKADFTRRLQGTMEQMKWPSKDLHFPDDLQNQWRENVELLLDLQKPELQGHAAGFTHHGNEPLVLLPLEVMVHPLELRFKYHFSGDKPTNRLDKPEYFLAHVMDLINNFGGFFASSLQPIFDQEAQNVGADLGWNFHNASHAVITALLPVLKHKITTFLPQISTHPQLLSHFMHELMNFDNEVRESWNYLPDPYSNEDWKGMTWDVLTKQGWFDRWLQVEKDFALARYREIVDAPDSGHIDYDGVDLSSTKPTKAAIRVNDLLETITERYQPLSSFSQRLRFLIDIQITIFDQFHERLHSALEAYLAMTSAIGRTVQGADAASIEGVAGLERLSRVFGSAEYLEKKMEDWSNEVFFVELWTELQERVRQNKDGGKNVAGTMSVADVASRTSQAVNNNNSQGTASEGALFDETASAYRRLRLRSESIITSTLTSNVRSALKPFSRVSTWATISATTPVAPLPPTSDLSPAMRTLSAEISFLSHALGIAPLRRIIRQVLLAIQTYLWGNILTRNTFSAAGASQFISDVEHLCSVVDTALGAAGQTGGSMRVMRKLAEGLVLLGLDTTTTTEPEDKTGGEGESRPGLWEVEKRLFKDNESARVVLAELGIETLTEAEARSVLERRAEIGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHM8</accession>
    <name>A0A317WHM8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_518462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466900.1">
        <property type="nucleotide sequence ID" value="XM_025610035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHM8"/>
    <dbReference type="STRING" id="1450535.A0A317WHM8"/>
    <dbReference type="GeneID" id="37112178"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF1">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY85883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="289" mass="31950" checksum="53D8C2AAE96EACE6" modified="2018-10-10" version="1">MASSYELYRYTPSLAAAVLFIILFILITAYHAYQMARSRAWYFTCFILGGIFQIMGYVARALAHSNTQSVSIYAIQAVLILLAPPLYAATIYMTLGRLIAYLEAEKLSIISIRWLTKIFVMGDVLSFLLQGAGGGLMSSGTASGMTTGENVIMGGLAVQLIFFSIFVIVATLFHYRIHQNPTQISISTSIVRSGWRNANWETTMVGLYIASILILIRSVFRMIEYAGGNDGHIMSHEAFSYIFDAMLMFFAMVVMSVFHPSKVLGSAGKEQNVGSSESVQLRRIYSNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WIR0</accession>
    <name>A0A317WIR0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_492965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466947.1">
        <property type="nucleotide sequence ID" value="XM_025609191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WIR0"/>
    <dbReference type="STRING" id="1450535.A0A317WIR0"/>
    <dbReference type="GeneID" id="37111334"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF76">
        <property type="entry name" value="TERPENE CYCLASE_MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="10">
        <location>
            <begin position="91"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="9">
        <location>
            <begin position="396"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY86356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="735" mass="84934" checksum="2706C0ECEDC64103" modified="2018-10-10" version="1">MAGEHIGPWRTEAQGHLSRDANGDLQTDYSRWRLRDDEGRQTWHYLESDEENEKWPQSVADKYFLGLPTGLPELPTPKTPLQCAENGLEFFSKLQLEPGNWACEYGGPMFLLPVLIITYYVTNTPIPPEYATEIKRYLFARQHPEDGGWGLHIEAHSSVFGTSMNYVTLRLVGVSEDDPRMMKARGLLHKFGGAIYGPHWAKFSLAVLGVMDWECVNPVPPEIWLLPDWVPFAPWRWWIHIRQVFLPMGYLWSKKFSHPLDPLTKQLRQELYTQPYDSIDFAAHRNSIHKADNYYPKTWLLNSLNSLLVNFWNPYLRVPAVVRRAEEWSWELIRMEDENTDYAGLGPVSNPFNMIACYEHDGPDSYSVRRHRERLHDYMWIKDEGMLMNGTNGVQVWDTAFITQCIVVAGFADDPKWRPMLTKALRFLEDHQLRENVPDQEKCYRQHRKGAWPFSNKTQGYTVSDCTAEGLRSTIQLQEMHNFPKLISEERLKDSVDCLLLMQNPSGGFTEYETTRASTKVEWLNAAEVFGGIMIGYDYPECTTASVTALSLFSKYYPDYRAAEIKAAKEKAVRYIKRVQRPDGSWYGSWGICFTYAAMFALESLASIGETYETSADSRRGCDFLISKQKEDGGWGESYLSSERHVYVQHEQSQVVQTAWAALALMEAKYPHKEPLRKAMQLLMSRQQANGEWLQEAIEGVFNQSCMISYPNYKLYWPIRALGLYARQFGNEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKX5</accession>
    <name>A0A317WKX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_80286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466952.1">
        <property type="nucleotide sequence ID" value="XM_025617672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKX5"/>
    <dbReference type="GeneID" id="37119815"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY86361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="110" mass="11736" checksum="1A4F09FF01132846" modified="2018-10-10" version="1">MPRGFSSCTLLGTGAGAGTSLLLPGQVSSIVDTVRLISTYPVSSIQYPVSSIQYPVLQPPPGWGIYNNKLRPDSLSHMIDRPTLHTIHLTMGSKLNDTVRSGNTSSSPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLB6</accession>
    <name>A0A317WLB6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_517688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467092.1">
        <property type="nucleotide sequence ID" value="XM_025610004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLB6"/>
    <dbReference type="STRING" id="1450535.A0A317WLB6"/>
    <dbReference type="GeneID" id="37112147"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF8">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="36458" checksum="EA7BC8A343D69CB2" modified="2018-10-10" version="1">MPDNQSPFDVPFDELPNPKQVWVGEPGSHEEGLGKLAILTPEVVAKAAATEIKTGRRVTMGWELTKLDYPNLNRQPCHHQIVPLLGGVAFDDIFTMNPQQSSQWDGLRHFSQTVDGQPERVFYGGTKAEEITDRKNDRIGLQHWAREGIAGRGVLVDYATWAEKKGIRYSTFSTHQIRLSDIEEIAKECGIVFQKGDILFVRIGVTKEWDTVMTDDQKRQYAGNPNPEHAGVEATTDMLRWLWNTGFAAIASDAISWEVYPPQSPDVFLHEYVLAGWGMPIGELFDLEALSRTCQDLQRWSFFIASVPLNMPGGVSSPPNIMAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLC8</accession>
    <name>A0A317WLC8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="6">2.7.11.22</ecNumber>
            <ecNumber evidence="5">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BO94DRAFT_556974</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the SRB8-11 complex, a regulatory module of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="6"/>
    <dbReference type="EC" id="2.7.11.23" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467102.1">
        <property type="nucleotide sequence ID" value="XM_025613906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLC8"/>
    <dbReference type="STRING" id="1450535.A0A317WLC8"/>
    <dbReference type="GeneID" id="37116049"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000426">
        <property type="entry name" value="Serine/threonine-protein kinase ssn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0010">Activator</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="15" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="31"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="PWY86511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="379" mass="42758" checksum="43AB55731B03F823" modified="2018-10-10" version="1">MLTHLLYQESLDTRKPPGTGYTSKVRVSDRYHIVGFISSGTYGRVYKALGKNGQKGEFAIKKFKPDKEGEIVQYTGLSQSAIREMALCSELDHPNVVGLAEIILEDKCIFMVFEYTEHDLLQIIHHHTQPQRHAIPALMVRSILFQLLNGLLYLHTNWVLHRDLKPANILVTSSGAIRIGDLGLARLFYKPLNSLFSGDKVVVTIWYRAPELLMGSRHYTPAVDLWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMMKIIEIMGLPSKEIWPGLVSMPEYSQLQSLAMSRAPGHFNRSSNLEVCAGTPGADGFDLLSRLLEYDPTKRITAQEALEHPYFKNGGPISANCFEGFEGKYPHRRTYHHLATSQNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN31</accession>
    <name>A0A317WN31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_596337</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467339.1">
        <property type="nucleotide sequence ID" value="XM_025616251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN31"/>
    <dbReference type="STRING" id="1450535.A0A317WN31"/>
    <dbReference type="GeneID" id="37118394"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="4">
        <location>
            <begin position="438"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="3">
        <location>
            <begin position="560"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="5">
        <location>
            <begin position="701"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY87131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="749" mass="82927" checksum="58740515E3411246" modified="2018-10-10" version="1">MSDPRSPSRHSPIFEDSRRYSADATVLLVGFVGAGKKILGIIASVALRRRFIDFDAAFRQEVQLSPQEYIARHGSARYRESELEVTRSLLERNSTGCVIVGLGWSGNHQQQQLLKDFARNHPVVYIRRGPADLRQFIATSLDTFSRIYAAGNQFFQSCSNFDFFNRRQESTDSVGRPLPAYMKLKETERVFLGFLGRILGRACRVLYSSEPFSPSHTYALQAPLSWLETEPDLEVLESGVDAINLIIDSAAVTAEHAFTDKLVKHMATVRKHTRVPVFVETRSPMQPELLESLLRLAPDVLACPLDSGPFRELNSIKGHTKIIATYQQSTPLSGSQCAELASLLERARSSGFDALRVTAEANVPADSLSCIALQQHMSESNFPVIIYHTGLQGRSSICLNPTLSPVVPPSMQDTGLTLESVQRALVSCYLLPKRKFTVFGQNVANSLSPAMHNAAYTACGLPHVYNIVCSDDFSDIHRLLHSADHGGVAITLPYKSDVLPFLDEISPDVKDIQAVNTVTIEQARPDGAITLKGHNTDYIGIRDCIHKHLSPANAIRPGITALIIGAGGMARAAIYACYQLGVRQICIYNRTIANAQTLADYYSHWADSNTGTRLHIQVLRSSDPWPEHLRQPTIIAACLPAFDMSQSPVSLHIPDAWLQSPTGGVLIDRLSLTKQVAYGHPQTPIRKKINTRSSKWVIVDGLVLLLEQGIIQYELFTKRPAPVHVMRRALEQAINTHPDPCLSTQQHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WND0</accession>
    <name>A0A317WND0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DAO-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_624104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467747.1">
        <property type="nucleotide sequence ID" value="XM_025617197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WND0"/>
    <dbReference type="STRING" id="1450535.A0A317WND0"/>
    <dbReference type="GeneID" id="37119340"/>
    <dbReference type="OrthoDB" id="512662at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016363827" evidence="1">
        <location>
            <begin position="28"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="73"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="533" mass="58235" checksum="19606EE01D7EAF4C" modified="2018-10-10" version="1">MGAILSSLRTIYLGICVLLADFADSNADYNALLGRISAPIHPIKNPSTSFWQQRPPFPELVDIQSPSLPDHADIVIIGSGISGASIAYTLLTQSSAESDGLKVVLLEARELCSGATGRNGGHVKCASYSDYALFKRRFGRERAKKLLEFERRALPLLVSFAQENGFEVAEARKVETLDVITDAGMWEKTKNMVQELKEDVPEAGKEVEVFEPDEGCEIFELNREQCCGVIRYPAGAIWPYRFVTSLYARLLSEFGSRFSIETNTPVVGIETRDDVMPFMVSTSRGKIPAYHVIHATDAFVANLVPGATGKLFPMRGHMTAQTPGAGLSRLDGSRSWSIIGKRGFDYITQRPRQGEDGGELMVGGGVVQSPSKGIDEFGIWRDDQMSGPISAYLEGIMPVTFGRDRWGEDKNGTRIKGAWVGCMGFTCDLLPLVGKLEPGLTVRTVTSRNDKQVGQFKVPPAEWISAGFNGEGMVLAWLCGVAVGLMALGLDEMDHEGGPGIPPGKVKDWLPDIFICSKRRVERFCVAELGLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNF9</accession>
    <name>A0A317WNF9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_535429</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467519.1">
        <property type="nucleotide sequence ID" value="XM_025611779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNF9"/>
    <dbReference type="STRING" id="1450535.A0A317WNF9"/>
    <dbReference type="GeneID" id="37113922"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2140.20:FF:000003">
        <property type="entry name" value="Arylamine N-acetyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01543">
        <property type="entry name" value="ANATRNSFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="315" mass="35784" checksum="F99CC65C7C18A2BA" modified="2018-10-10" version="1">MASYTPQQLELYLERIRYPGSATTSRLQCLQQAVTDNPLAALAELQRRQLSSIPWGNSALHYSTHRTISIRPACVFEKLVARALDGYCMENNTLLYAVLRSLGYQVYPTGGRVCLAASGQTYEGVEKLWTGLSHMVLIVVIEGQKYMVDVGFGNNGPTSPLLLKPDFVSVCMAPTETRLVYDALPEFVDQTQRVWIYQIRYTPDSQWIPMYSFLGTEFLPQDFEVMNFATSQRQTSWFTQTLVCSRMFLDEKETAVQGLYVLTGKEVKKRQFGQSDVVETLHCEADRVTALAKWFDMNLRDHEVEGIRGLVSEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPV4</accession>
    <name>A0A317WPV4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_556647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467355.1">
        <property type="nucleotide sequence ID" value="XM_025613879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPV4"/>
    <dbReference type="STRING" id="1450535.A0A317WPV4"/>
    <dbReference type="GeneID" id="37116022"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="215"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY87147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="437" mass="47422" checksum="9EECFB828BFE449B" modified="2018-10-10" version="1">MNSYLLNRALGSISPSTFHVAQTSRLIQHLEPAPGIRFSSRKDIPAGDRARNGSPAAITQLGLDGEIFAHKAGVNVLAIDQYDGRFMVSGGADPSVHLWDLETRGSDLNHVHHSVASVNKASHEDAHTRAITSISIYPFDPTPSTILTTSYDGTLKLSVLAPGAITPVHTFNLDCTPYTHSLSSNPNSPLLIAVGTSEKPVRLLDLRSGLSTHGLPGHDSAVLSVSWAPHQPHILASASADSRVILFDIRRGGHNSAIAALDMDDAVGLDARIRVWKSDTGANTFVHFGPRVRNSATAHLAERAPLIVPRGMVMPGQETLLWPNFNDRDDRGEIFMFDLHEGTFVKLLRVPGLMIGRQQFQGRTSALSAARINSLAWRGNGASGEGLEMFSAHGDGTIRTWVSREPEGEPDEADEAERADRKRKRDVLDEIYRGFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQ55</accession>
    <name>A0A317WQ55_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Creatinase/aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_624268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467256.1">
        <property type="nucleotide sequence ID" value="XM_025617202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQ55"/>
    <dbReference type="STRING" id="1450535.A0A317WQ55"/>
    <dbReference type="GeneID" id="37119345"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000016">
        <property type="entry name" value="Putative curved dna-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="3">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY87048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="405" mass="43904" checksum="E1D0A29CF4E7589C" modified="2018-10-10" version="1">MAETQAPEVDYSLNNPDTLTKYKTAAQISHKVLEAVAGWCVEGSKIVELCQKGDQLLDEEIAKVYKGKKIQKGISHPTTVSPSSYVTPYTPLVSDAAEAETTLKAGEIIKIQLGAQIDGFGAIVCDMVVVADSSSSSDVVTGREADLIHATHYANELLLRLMVPPGLLASGTEEEKQKAAAQKPPTQAQISQLIEKVAKIYDCNVVENTTSWQFERNEIEAEKKIILSPGTGVKGEGVPDVGEVWGVELGLSLGSGKVKTLPHRATLHRRTTTTYGLKRPSSRQTLSEVVKKFGQFPFSLRQLEDEKAAKVGVVECVRGGVLRQYEPAGDADNAPVSRVLTTIAITKNGITRLAAPTTPDLSKFQTDKKIEDEEILKILERPLAKSTGSKKNKNNKKKTAKKADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQN9</accession>
    <name>A0A317WQN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_50353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468105.1">
        <property type="nucleotide sequence ID" value="XM_025609478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQN9"/>
    <dbReference type="GeneID" id="37111621"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY88743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17778" checksum="84B2BD7E1E6EFE77" modified="2018-10-10" version="1">MLPSTIDPETPVRVNPPGQALSIQYVLLRSTTTYILKKGGLQHADEQTKSCRAIMGRVLAATSARARRVVGLEMRAPSDYYSAQFPRHTILLHHKSTTNNNNNNNNGVDSSLVSSTRLPFSYPSFSPSVKGRSLLPFPHGPPSRRPLHTYLPAFYPLNSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRJ2</accession>
    <name>A0A317WRJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_516220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467705.1">
        <property type="nucleotide sequence ID" value="XM_025609953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRJ2"/>
    <dbReference type="STRING" id="1450535.A0A317WRJ2"/>
    <dbReference type="GeneID" id="37112096"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY87922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="540" mass="58785" checksum="673075EB9FBD8A1A" modified="2018-10-10" version="1">MSATQLLNPKAESRRRAEALKVNISAGEGLQDVLKSNLGPSGTLKMLVDGAGGIKLTKDGNVLLREMQIQNPTAVMIARAATAQDDITGDGTTSVVLLVGELLKQANRHISEGLHPRVITDGYEIAKNEALKFLDQFKLERPIDRELLLSVARTSLSTKLNSALAEKLTPDIVDAVLAIHRAPEKPDLHMIEIMTMQHRTSSDTRLIRGLALDHGARHPDMPKRVENAFILTLNVSLEYEKSEINSGFYYSSAEQRDKLVESERKFVDAKLKKIVELKQQVCGTDPNKSFVVINQKGIDPLSLDVLVKNGILALRRAKRRNMERLQLICGGIAQNSVEDLTPDVLGWAGLVYEHQLGEEKFTFVEEVKDPKSVTILIKGPNQHTIAQVKDAVRDGLRSVYNTIVDGCVIPGAGAFQVACAAHLSSEAFRKSVKGKAKWGVQAFADALLVIPKTLAANSGHDVQDSLAALQDEQSNGNTVGLDLTTGEPMDPIQEGVFDSFRVLRNCIASSTGIASNLLLCDELLKARQMGRQGGPGGMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRZ6</accession>
    <name>A0A317WRZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Laccase TilA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_545864</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468147.1">
        <property type="nucleotide sequence ID" value="XM_025613264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRZ6"/>
    <dbReference type="STRING" id="1450535.A0A317WRZ6"/>
    <dbReference type="GeneID" id="37115407"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042440">
        <property type="term" value="P:pigment metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13850">
        <property type="entry name" value="CuRO_1_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13876">
        <property type="entry name" value="CuRO_2_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13898">
        <property type="entry name" value="CuRO_3_Abr2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000036">
        <property type="entry name" value="L-ascorbate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000061">
        <property type="entry name" value="Laccase TilA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF488">
        <property type="entry name" value="LACCASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016396439" evidence="7">
        <location>
            <begin position="24"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="10">
        <location>
            <begin position="41"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="8">
        <location>
            <begin position="183"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="9">
        <location>
            <begin position="470"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY88785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="600" mass="66037" checksum="D02A71650CD77B12" modified="2018-10-10" version="1">MHPFRYGLALLASILCLVSWANGSGLHVRTTGNTVRFNLTLTWEDWAPAGVPRKMILMNGQFPGPALQLQQGDDVEFLVISHLPFNTTVHFHGIEQLGTPWSDGVPGLSQRPIAPGDRFLYKWRATEYGSYFYHAHNRGQIDDGLYGAIYVHPDDSLEKPFHLITNNATELQAMQAAEHNTKPVILSDWRFLTSEQLWRAEEETGLDAYCVNAILVNGKGAVDCPGQQAQNKLASAAQKQILGNLSMTDTGCISPMLVSTEGTFPHNYSAMPPTMFYGCIPGNGGTARLLVDPTVNYVSYDLISTAGVSMITFSIDEHPMYVYAIDGRYIEPTLVDAVTVANGNRYSVFVKLDKPAGDYTIRAANSGINQVLNATAVLSYSNAIKTQQSSSVASIDIHGSPVSSNYTLLDESTIMPFPVEVPSQEVAQTYILRIGHYNASYRWTMGNSTFPLSLEAASPLLFYPSTAKPDLTIKTLNGTWVDLIFHVDGPIQPPHPVHKHSNKFFVIGQGSGVWNYSSVAEAMHYIPESFNLKTPQIRDTFITPAAATGNTWLALRYQVVNPGAWLIHCHIQVHLSGGMALAMLDGVDEWPEIPEEYQPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSK0</accession>
    <name>A0A317WSK0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_585080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468063.1">
        <property type="nucleotide sequence ID" value="XM_025615673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSK0"/>
    <dbReference type="GeneID" id="37117816"/>
    <dbReference type="OrthoDB" id="4147798at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="116" mass="13158" checksum="67F5800A1D82AADB" modified="2018-10-10" version="1">MGQRHNRRRTRPRSRNRSVNSIPFAPFPRPVDLCTSAVPSALDCPEIPALTWHYGHLIWQKRDRALRMEASTLEAEQCRLFGGVPGDDVGLCYRMLEYFGGLDYIDCPQSLNALPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT02</accession>
    <name>A0A317WT02_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_534263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468397.1">
        <property type="nucleotide sequence ID" value="XM_025611500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT02"/>
    <dbReference type="STRING" id="1450535.A0A317WT02"/>
    <dbReference type="GeneID" id="37113643"/>
    <dbReference type="OrthoDB" id="9997422at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00138">
        <property type="entry name" value="PLDc_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="669" mass="74996" checksum="16255FA0A6709732" modified="2018-10-10" version="1">MAAPLRPWSPASESTWMPLFKLSGAVCSLCLASIVFWFVRQPKSANRVRVTMLSDTVYELCHDDKTVSSELLNDPSQSGPKVFERLYHDRKSKLHSHDSKESADDAKNELKKVLECGNWGNSEPSELFLKIYHDALCSLDKNPMAGVVSPPLMGSHGVVPLTIIAPLPDLCRHMANCIVRAEQEVFLATNFWIHSDASTLVTNAFRELSRRAGERGTKVIVKMVYDRGDPHQLFENHLPVPEKKYTSEKVQLPPAEEIPNIDLQVVNYHRPIFGTFHAKFMVIDRRIGLLQSSNVQDNDNLEMMIQVEGPIVDGLYDTALISWGRPLEPPLPMLASPATGAPIPCHSTQQPDYDAPDPGPLPELTVDDHHYDPDIRREAQRMNGLLLPRDGETMTQAVTRRLNTTIQTDMTADAPESDQDPIMEPYLVLQPHNPFPMAVINREPWGAPNHSSVHTPQNSSFLSAIKNAQESIFIQTPNMNAEPVIEALIEAIKTRDVTVTCYLCLGYNDAGELLPFQNGTNEMIAHRMYKALDTDDQRFRLRIFNYVAKDQTRPIHNKFKRRSCHIKLMIVDERVAIQGNGNLDTQSFYHSQEVNLLLDSPLICRAWRHAIDRNQNTAFYGGVSPEDGCWHDPNTNEIPVGSIGMNPGHFSWAKGAVGAVQRVRGAGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTQ7</accession>
    <name>A0A317WTQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_44079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468620.1">
        <property type="nucleotide sequence ID" value="XM_025607506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTQ7"/>
    <dbReference type="GeneID" id="37109649"/>
    <dbReference type="OrthoDB" id="4955540at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY89709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16766" checksum="413811EF90D2D4E5" modified="2018-10-10" version="1">MSTVNVVKDYFYRGFTPKTEERARQLIALAYQTARDQKLYPRAILIRSEIHKTTSMSGMHQVDPLGYHITLCFKDEQQLLRGTHVSSHGYVRDQDNLEFIQATHTEEKSDNTKRQRGKRMCGHQKICLFRHQTLATATCHQTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUR5</accession>
    <name>A0A317WUR5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_44766</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467950.1">
        <property type="nucleotide sequence ID" value="XM_025607525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUR5"/>
    <dbReference type="GeneID" id="37109668"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="141"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY88588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="336" mass="35971" checksum="C7584530E3410E66" modified="2018-10-10" version="1">MSHPKKVLVTCATGNQGRGVVQHCLAAGHQVCAYVRDPTMPTATQLAQWGATLVPGNLDDLEALRTAMHGVDAVFLTEVQTGDCEGDLQRSSNVILAAQEAAATVTHVIVSTAIKTGQHASFPGWGKPDSHGGGEDEDDAAARAHPMRQYWLNKHTLETRVRAAAAASSSSDGFIRHWTIVRPGHYLQNLLPPVNALTFPGFEQDRILRVAWWPQTQLPWVDAGDVGIVVAVAITDPERYSHRAIDLAVEALTVEQLAGKLDRALSKGGVPVSVEYRSEEEVDEMIRLGNPVAAAQQWANQVPGGDAVGNCRDDLGTLVQACTSVDAFLAANASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WV95</accession>
    <name>A0A317WV95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_623146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468722.1">
        <property type="nucleotide sequence ID" value="XM_025617131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WV95"/>
    <dbReference type="GeneID" id="37119274"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF4">
        <property type="entry name" value="ESTERASE ALNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY90344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="256" mass="28621" checksum="F447B37CB76E4FD2" modified="2018-10-10" version="1">MRFLCLHGNGSSARIFDTQLSALQRALGSRYEFVFIQGEFPSDPGLGVDGMYPGPYYSPFDLPTKDQLSDAHALIDEAWESDGPFDGLVGFSQGGSTMASYLLQPETARKPFKCAVFFCSNLPFDPMSSPWKFVDKDHFVDATTGEEISADDLMRSIPEVKLFDTSRYPTLRDELLLRRYTVGQGDTIQIDLPTVHVYASNDSWYYEQCIATEKLCQEVNRETVLHKGGHSVPWDAGTTTEIVDCIQNMQQAVDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW96</accession>
    <name>A0A317WW96_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_534371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468503.1">
        <property type="nucleotide sequence ID" value="XM_025611531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW96"/>
    <dbReference type="STRING" id="1450535.A0A317WW96"/>
    <dbReference type="GeneID" id="37113674"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY89592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="198" mass="22113" checksum="D0571ACC20FA40A8" modified="2018-10-10" version="1">MEHVSRVVQQPRAVVSRLQRYYFSRHYHLRVSSSPVVPPTHLRQVPLLRIRAATAATNLPSSLIAPSLRIASRHASTMADPQFSEGTDPEQARQGLQALQEQGWALDEDGQGVKRTYYFRSYFKAVSFVNVVASQSSTKKHHPTMTVRIGSVDIHWTTHNPRGLSEKDLEMAQHCDEAAELMGAVEQGQGKKCAPGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYD9</accession>
    <name>A0A317WYD9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transport protein SEC61 subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_533559</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469142.1">
        <property type="nucleotide sequence ID" value="XM_025611355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYD9"/>
    <dbReference type="STRING" id="1450535.A0A317WYD9"/>
    <dbReference type="GeneID" id="37113498"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY91414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="478" mass="52154" checksum="955225D997DA0537" modified="2018-10-10" version="1">MSGLRFLDLIKPFTPLLPEVAAPETKVPFNQKLMWTGLTLLIFLVMSQMPLYGIVSSDTSDPLYWLRMMLASNRGTLMELGITPIISSGMVFQLLAGTHLIDVNLDLKTDRELYQTAQKLFAIILSFGQACVYVLTGLYGQPSDLGAGICVLLIVQLVVAGLVVILLDELLQKGYGLGSGISLFIATNICESIVWKAFSPTTINTGRGPEFEGAIIALFHLLLTWSDKQRALREAFYRQNLPNIMNLLATLLVFAAVIYLQGFRVEIPVKSSRQRGMRGSYPVRLFYTSNMPIMLQSALCSNIFLISQMLYSRFSDNILVKLLGVWEPREGSAQLHAASGIAYYMSPPLNFKEALVDPIHTAVYITFMLVACALFSKTWIEVSGSAPRDVAKQLKDQGLVMAGHREQSMYKELKRVIPTAAAFGGACIGALSVASDLLGALGSGTGILLAVTIIYGYFEIAAREGDIGSGLKGLVPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYM8</accession>
    <name>A0A317WYM8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_533928</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CBP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468820.1">
        <property type="nucleotide sequence ID" value="XM_025611427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYM8"/>
    <dbReference type="GeneID" id="37113570"/>
    <dbReference type="OrthoDB" id="5576752at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY90442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="116" mass="13695" checksum="F059D1C504B5608D" modified="2018-10-10" version="1">MSRAGTWMKMLGCGIVICVGGPAFVQYIRPTDEELFKRYNPDLQKRSLEEGDRRARDFDEYVGKLKQWSKSDKHIWFAAQEQQEQKRLEVEATRNQAKEDAKVQREEMRKELLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYY2</accession>
    <name>A0A317WYY2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_462918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468920.1">
        <property type="nucleotide sequence ID" value="XM_025607994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYY2"/>
    <dbReference type="STRING" id="1450535.A0A317WYY2"/>
    <dbReference type="GeneID" id="37110137"/>
    <dbReference type="OrthoDB" id="5350396at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="681" mass="75703" checksum="A920472BE8870053" modified="2018-10-10" version="1">MRSITSFFKRPDFSIAHRDPQPKDRGDDPASASPTSPPAEAPSSLHSNDPSLDDPGSQLNLSLSQSIKDDDDKVDLLHSFLSTGSAAKDPSPGTTFNSSQRVVKKGKEVIISSDGEDTDSISSIESPDDILMNIAKPVDSFRGNESSKPGMSLRDRSVKDPKSDKRFGFPASAPKYKNTLDSLVVQAVDDNETEAGIAKLRAAFEKEDMRKNEKQNAMVHGSTLPSTRLNEGVLASALGDQDDELGLRRLLDAVRRTEALDLEKSWQFFIYESELPPALEFPRDCIGENTFMRGLRERHSRERAFHSGIVDFALSRSFLPDALISWIFQAVPSETQDSIRQAYCRAFKHANAERIKTLIRPDDLDRVFQQLGATPSALAVFETIFPDAHVTTYNVKTNSPREGALLSVFDLLCGAAELFADDTRERALNLLFRLTLDVSLTSNFLICSELERTIVTMLESAPEDTADDLALHVSTSAFDTIKDATLQSRLLRHILPTSDWLAMLRCRLAVSFLTGSPLPLSEPPEKVLNVERITSILNQRRFDLKRYKSKGQNDYDYGGLGAVTVLLNIAIDAGRCEAGFPDKEAERKFNAAVDALADRLKFIFTSIEDSGASHLKRTLAKEAIEALHYRVIYSVRSKPRPKKSIFGVPEPRRENKDVFASFTAVKKDDDELPIRAHEDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0B8</accession>
    <name>A0A317X0B8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_564927</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469339.1">
        <property type="nucleotide sequence ID" value="XM_025614460.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X0B8"/>
    <dbReference type="GeneID" id="37116603"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="881"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="913"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="978"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1091"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="273"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="606"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="916"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1186"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY91611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1406" mass="153880" checksum="BAB54B4C1C708318" modified="2018-10-10" version="1">MAASCSPAADNTFGPVLACPATFDFTLLFEQSILSIGPSALFLLLVAWRIWSLHPENIKTVANNAYWQKLAVAICLIGIQVASVVLWARHNILRTAIPAVSLSLVDALSITFLSAIEHNRSVRPSSLLSIYLFLSIGFDAVQVRTLFIRHYPASLAALSAASVALKLLLLALEARTKRRYLKAPHRDTPPESTSGIFARTIFWWLNRLFLAGFRKLLTLEDLFPTDVDLKSGPLRQKIRVAWERYKSSNTRSLILATAVSLRWAILRTVFPRLCLIGFSYAQTFFIQRAIEHLHKPDTQMTRNEGYGLIGAAALIYGGIAISTVHYKHQLFRMITMFRGAAVALIYDHTLVIGDGACTESAAVTLMSTDIDMIARSLEQASEMWARLVEIAIGIWLLERQLAAVCVAPILVILLCTSVQMYMATFMPARQKVWVGAIQRRVGMISTALRSMKSVKMLGLSETLATTLQGQRERELNLSKDFRWLIVWLNVVASLPQMCASLVTFAAFVIRAKIDHSQPLSTVQAFTSLAIIGLITSPALQLLSSIPAVTAALGAFDRIHKFLTSHAISTQPTERSPEPDVGNGGDSHDSEVQLKILAPKVHSELVVALANAYIRPGESDFCLEDIDLKVKPNTVMIVTGPVGSGKSTLLKALLGEVSCERGTLARTSDAAYCNQTPWLQNTTIQNNICGKDLDLDWYREVIRACALEPDISRMPHGDQSVVGSGALKLSGGQKQRLALARAMYSRKLLLVLDDPLSAVDSKTARFVIDSLFGTNGLCRRIGAAVIMATHTDQHLYVADEAVVLGSNGRIEKQGPVRSLCLASFPDITETKSESVQPDSDEKSTATKKVETLTVDDIADISRQTGDAAVYSYYLKAIGWRHTLGACIIIIIHTFSSIFPQVWLELFTDDDGKKAAQFIGIYVLLAVAAQIMIKIVLKSGLELHRILVQTVTNAPMHFFAEVDSGVILNRFSQDMTLVDAVLPTMAFGTVLSVAQCFAQVALISLGSSYMGITIIPCLLVLYGAQKVYLRTSRQLRFLDLEAKSPLYTWFVETLEGLSTIRGLGWQRSFVAECLSRLDDSQRPYYLLYCIQRWLNVVLDLLVAALAVILIALATSLRGSTDPGKLGVSLTAIMAFSQTLQDVVSSWTSLETSLGAIARTRSFEMKTPSEHHAEETFIPPRAWPLHGDIDITSLSVSYDDVTRALDNINLSIKAGEKVVISGRTGSGKSTLFSALLRLVDTETGTITIDGFDISIIPRNILRSSIIAIPQDLFILPGPIRFNLDPSGRSTDEVLISALAKSNLLAVTTSRGGLDAELSSSTLSQGEQRLFALAVALVRKWNKDNDVCTGGGILILDEATSGTDAETDGLIQMIIEQEFTGYTVLHISHRPGMVRGVDRVVELENGRVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X0D5</accession>
    <name>A0A317X0D5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_533191</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469463.1">
        <property type="nucleotide sequence ID" value="XM_025611286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X0D5"/>
    <dbReference type="STRING" id="1450535.A0A317X0D5"/>
    <dbReference type="GeneID" id="37113429"/>
    <dbReference type="OrthoDB" id="4500730at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="83"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY91735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="366" mass="42108" checksum="8B66262CE2AF030C" modified="2018-10-10" version="1">MAAELDASGYVSSNVITPTEKSLEFFREQQRFMDNQDYQREDHRDARRILNIANPRVPRMRSMNRSAVLKFWQPVAIARILEIHQSPYLRGAILGDSVGLGKTCETIAVILKIWEDYNQSVIDSKQQGRPIPAGRPFLVIVPPALISQWYSEINRVTDKFTAFIYYGEERPVQGMRTVGSRLRKTDTIFDGSPINARTVVITSYQTFAYRHGLTAVKAWYSETKEFCPKVLLRCPVEFLFSLDSCFTDVILDEAHILRNPETSQSIAVHWLEANFHLLITATPIYNSRKDFEGYVPLLFQPSSLWDKLDRAQLQHFRDQIFYLPLGHPARRLCCTVQAVEDYVLADRMPPSVVGNRLQLIFSQLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2P4</accession>
    <name>A0A317X2P4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_379252</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469495.1">
        <property type="nucleotide sequence ID" value="XM_025607249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2P4"/>
    <dbReference type="STRING" id="1450535.A0A317X2P4"/>
    <dbReference type="GeneID" id="37109392"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000030">
        <property type="entry name" value="Putative histidine kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000136">
        <property type="entry name" value="Sensor histidine kinase/response regulator Fos-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="13">
        <location>
            <begin position="235"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="14">
        <location>
            <begin position="310"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="376"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="631"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY91767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="750" mass="83952" checksum="1786A930D8470415" modified="2018-10-10" version="1">MPYSRSTVPDAARTLLPPPQDRVKPPLVPYVVTMDLNKRLFHLDIENKTQPQPLNFSMVTTPPDDDDDDEGNHMKLDREPTQSPPSPDNRRVDSHGMSEVSLRESDAALSRIYRFTPIPTVILDSSLNVVEVSESHVAFVQLSRDALLGSFICDVCPRKLPALDVATLYGALRAAITTQDVQLIDKICIDDISSYYSLRITPIFEKSNLLYLVLEALNVTKDLTKSAVDTRRSYVNDTYKVLLDTVKDYAIFMLDTRGYITTWNSGAALLKGYSAKEIIGQHFSTFYSEEDRVADKPGKELTVCLREGKVEDEGWRYRKDGSRFWANVLITPMYELGRHIGFTKVTRDLTERNAAETRMIAAFEESSKLKTDFLANMSHEIRTPMNGMLLALTSLMGTELNDRQREYASIIEDSTSVLLQVINDVLDYSKLSSGSFTLHPETFSIDGVTGAVVRNCKGALKPGVELTSYIPPNFPSKVEGDPLRYRQVLQNLVGNAVKFTEKGYVQVHNSFSNDAEDPNVYHIMTEVVDTGVGVPEDALGSLFTPFTRFAESGSKRYQGTGLGLSICKSLAELMDGSVGYRPNPEGRGSIFWLTTKMHRVNVAVPNRMAGTPVEEAGDIERKVHDIAPHKHVLLVEDNLVNQMVMLKLLQNMGFARVDTAWDGAEAVRLVKQQPLSYNTILMDISMPVMDGVEATRQIRHMGLDMPIIALTGNVMEGDADEYLNKGMNDYIGKPIHQKQLMRLLWKWMGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X381</accession>
    <name>A0A317X381_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="6">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_622224</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469777.1">
        <property type="nucleotide sequence ID" value="XM_025617055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X381"/>
    <dbReference type="STRING" id="1450535.A0A317X381"/>
    <dbReference type="GeneID" id="37119198"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF83">
        <property type="entry name" value="DEHYDROGENASE (CYTOCHROME), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="128"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY93016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="559" mass="60720" checksum="B445B87C61189B93" modified="2018-10-10" version="1">MRAWQTTSLRACARRSSLNARRVQRPPFSSRGRHSNFSTQAGNAPRKSATLPILGSIVATAAVTLLASEAWRAKTDTQQVSAGAKYADGPTMLRAVEEIKQVIGDENVSVDSDDIEAHGYSEWSTSNTTARPVAVFSPASTEEVSQIAKICTKYKVPMVPFGAGSSVEGNFAAPHSGVCIDLSRMNQVIELYEQDMNVTVQAGVRWTDLNEQIKSTGLFLPMDPSPTAYVGGMVATNCSGTNAMRYGTMKDWVVNLTVVLADGTILKTKRRPRKSSAGYNLNALFTGSEGTLGIITEATLKLAIIPEESSVGIATFPTVGDATAAASKLIRDGVPLAALEFMDDVQMKIINQNGGAGGRFWSEAPTLFLKFTGTRTGITDSIHRTRTILSKNKSNELVFANSREEGDNLWAARKQSLWAILAVRPEGTEIWSTDVAVPISRLAEIVELSKTESSNLGLFSTVLGHVGDGNFHQAVMYNPQKPEEYQAVKACVSRMMKRALEMEGTVSGEHGIGIGKKAYLEEELGTSTMEFMRGVKRSVDPYWLMNPGKVFDEYYQGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3Z4</accession>
    <name>A0A317X3Z4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_372773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470115.1">
        <property type="nucleotide sequence ID" value="XM_025607221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3Z4"/>
    <dbReference type="GeneID" id="37109364"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="204" mass="23418" checksum="BF0771493A3BB891" modified="2018-10-10" version="1">MGDLNWMSKGKNFFSPLILRVRIVFLFVHYLCIIGVVFLAHLRTKSPSYQSDFCGRKTWVPCLSWSSLNFCYIHVPKLRAPHLVIYSSPTASVNHSKGEVGRYGVFPTRFSFSQAYPPSLYNLRRDFCIQDTLRVEMATSAMESWLQCSGTPSILRRYCLIREGTTEYSLLVIGMLYCNDMAPYDCTSYPQANLSQQRSASFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5C2</accession>
    <name>A0A317X5C2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_564498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469478.1">
        <property type="nucleotide sequence ID" value="XM_025614423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5C2"/>
    <dbReference type="STRING" id="1450535.A0A317X5C2"/>
    <dbReference type="GeneID" id="37116566"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000041">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY91750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="213" mass="22451" checksum="D25124A3B59820DF" modified="2018-10-10" version="1">MSVTLHTTQGDLKVELFCEAVPKTAENFIALCASGAYNNTPFHRLIPGFMIQGGDISLGPAASSTNNTKPILPFEDIPKGGTSIHHPGALNQEIHLPALKHNTRGILSMASRPVKDRTAPGAQGATGATINGSQFFVTFAAAPHLDGASTVFGKVLNLTAQDEGGDVLTRLEKANAKVDKKGRVVQPKEGEEGGEFEALMIKSVTIHANPFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5I0</accession>
    <name>A0A317X5I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_532371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470212.1">
        <property type="nucleotide sequence ID" value="XM_025611110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5I0"/>
    <dbReference type="STRING" id="1450535.A0A317X5I0"/>
    <dbReference type="GeneID" id="37113253"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="529" mass="58393" checksum="C55F84A9F002B308" modified="2018-10-10" version="1">MGKPSEGCGTCRARKVKCDEARPVCGRCRKAKRTCSGYRDPLSLWFRDESESVARRVKGSANKATGPPPAEPPVLTVARKKITPEAYLGHHSRQSPIPIVNFVLDHTFQGTCFFLNTYTWFDASSVVRSSLQRGSGPAESLGEKAMMAGVASVGLANLASLHRSPSLRLSARHEYATALQLTNAALCDPVLVRADTTLTAIVCLSLFEIVACERDESLESWIEHSQGVATLLELRGSEQLLRESGFWMFQALRNQVLIGCLQKKTRLPPVLVDMPDRIAASLQTHPFPVDGDRLVKVVAKFSELQADIREGIISDSTEIISIAMMIDSELAHYASTVSAEFSYATGTWPDDVISREKDEHNFTHFQGSYHIYQSTWACNVWNNYRYIRILVNNVILKHLGSMARKSQWGVEHGSFKDQYVRIRGLTRQLATDICCSVPYKFGVAGRAEKNVVDSVTSHAGTGFTLLLPLFVAALVDGALSPIHDWAMRCFNIIGREMGIDTALTLIKLLESRTDAIATGEAAWPWDASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6F0</accession>
    <name>A0A317X6F0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_622366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469973.1">
        <property type="nucleotide sequence ID" value="XM_025617076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6F0"/>
    <dbReference type="STRING" id="1450535.A0A317X6F0"/>
    <dbReference type="GeneID" id="37119219"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF265">
        <property type="entry name" value="MYB-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="56"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="107"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="44467" checksum="F9783198A9A36666" modified="2018-10-10" version="1">MPRPPHRWTLEEDRILSKAVHAQLAHGTVKDWTAVASEIPGRTNKDCRKRWHNALAAGRNKGYWTPEEDCLLERGVRLHGETWTEVAAIVSTRTADQCAKRWKQCLDPQLDHSEWTEAESCRLLEAVCAKGRRWKQIQVEYFPARSRNSIKNQFTIVTRRRMKSQNKNDEIAPKDGALGPDSGAIQLKHQAEDEMEIDDDDGGDDDEDEVQEQDNQGGYEKSEEDVSYWEAQGPHSSSAEVVASPSFDLAQITPNIGSPDLMYEPPWDIFTEISQDALYAALRAGPDFDLRGIALGDSDFEICTSMPMIEGLPDPQQDEMMGETNNLPSLHPSGRAEVPISTNQSYQRVESAHYTARSASDASKVVLTIEEPDTMTVNSLLQVAVASNSRFHFERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X797</accession>
    <name>A0A317X797_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_510164</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470822.1">
        <property type="nucleotide sequence ID" value="XM_025609723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X797"/>
    <dbReference type="STRING" id="1450535.A0A317X797"/>
    <dbReference type="GeneID" id="37111866"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY94061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="403" mass="45341" checksum="1A51393B9D448532" modified="2018-10-10" version="1">MPIPILTQGITEGFSSIPYLWTILKVVPWAILLAALKYYFGGARNTSERVMHSKVVMVTGGTSGIGASVVHSLASRGAQIILLTQHSPSDIFLVEYIDDLRQKTNNQMIYAEQVDLSSLHSIRTFATKWIDNVPPRRLDMIILCGNTNPPVSRKQQLTVDGLDEEWMVNYLGNFHLLSILSPALRVQPAHRDVRVIFATCSSYIGARFDLRLLQREKPKKVKKGVSLYGLSKLSLMVFAQSFQKHLNAFKRPDGQPPSARVIMVDPGFSRTPGNRRWMTGGSLWGLLVYLITWPLWWLVLKSPEQGAQSILYAAMEARFGQGEGGWLIKECKEVDVARREVKDEEAGKLLWQFSEKLIEVKEKESAVRRALEAKEKEQAEKQGQPKASAKEPTPGSRRSRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7J4</accession>
    <name>A0A317X7J4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_532469</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470288.1">
        <property type="nucleotide sequence ID" value="XM_025611125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7J4"/>
    <dbReference type="STRING" id="1450535.A0A317X7J4"/>
    <dbReference type="GeneID" id="37113268"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="305" mass="31891" checksum="BE11742574F1CA3B" modified="2018-10-10" version="1">MDAIQKTIIDPLQPLLRPVVSAMPEPVHDAIVSLIGSSCHNTLVVDLDVSKDPACTSLAISKALGIAIVGASAIVKVPQILKLIGSRSSAGVSFVSYALETASLLITLSYSVRNQFPFSTFGETALIAVQDVVVGVLVLTFADRPTAAAAFIAVVAASVYALLFDQTLVDAQTMALLQAGAGALGVASKAPQIYTIWREGGTGQLSAFAVFNYLAGSLSRIFTTLQEVDDKLILYGFIAGFSLNLILAAQMLYYWNSPAKSQKKKKPVAVAIPAKAPTATSSGVSPRPTGSPKPTGKAPTTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X832</accession>
    <name>A0A317X832_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small nuclear ribonucleoprotein Prp3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_621782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471132.1">
        <property type="nucleotide sequence ID" value="XM_025617020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X832"/>
    <dbReference type="GeneID" id="37119163"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF10">
        <property type="entry name" value="DUF1115 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G14750)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038021">
        <property type="entry name" value="UCP038021_RWDD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="165"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="290" mass="31771" checksum="24BC4AF991BA6D7B" modified="2018-10-10" version="1">MAHEQSSLLPADMLESQLSTIDLLMAMFPNPGELEIPASTSQCVEKLRDWCQAPAGVPSGIPSSILLAVCLPLADGEKTIQVNISIPLHSSDPVPEQPPPPSYTLRQPDWMSKAEVATLAAAMPQDDVFEAFEYVREEATRFLEAQQASAPDATAGGSGSIVRVWFYFPSLSTRKKRDDLVNHAAGYALTGFVLAGKPGVLCLEGGSTDIDDYMSFIKTYSWGDIPSHQKKVSERFRETEGVQRVFSGMEEITDSLGERSGQRANRGDMQALEAWLRARGLQEAFEQVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X868</accession>
    <name>A0A317X868_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_485320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470613.1">
        <property type="nucleotide sequence ID" value="XM_025608978.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X868"/>
    <dbReference type="GeneID" id="37111121"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="818"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1250"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1233"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1757"/>
            <end position="1858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1233"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1243"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1764"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1807"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1817"/>
            <end position="1832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1887" mass="212515" checksum="0F043804587ED8FD" modified="2018-10-10" version="1">MADSNKLLTWYNDVYSRTVDLVGDYAGSELFIIEGDSLLLHCLTDDQLHFSSGFQLLHATYIVERFLANLRQRNCNFQIVFFSEHSVISIPPHVDKASRPKYSLAREAILQHLLQNAPDAVPSVRVKCFNRYDSQEFREYLAAEGVYFLMCHDGALMEHNQHGKESVTVGDNENLRVSGDSDFGSEGTVDGALPTIGPTSAILRSMICWFIAHGYNISLLNSVECRDTKVFTTVLEGSAENAQNIYHARLKPTGDPESSEPDTQKLAEFDTKTVHGHIKAHPIAQRSLAKSSSTEFMLRKFMDIIGTTCHHVTQREWVSVLTASTVLNFDSFEANDMVAICALLLHTVILSECKLSDRTYSPTDCTGELFLVQYAEMARDIITSPLWHEAVRTQSICCDLADLMDGRLFLQLLELCRTTPRGFTLSQSVLTRFSVLTSLVKYLCGSEVSGIKIINEADKKTASGNRRTTVSSKHLPNDQKEPANAVLPFNNPVFDPHLRPISLVVDESATEMSDFVVSRTFEEMSHWHNHKRPLDKRNEGPMPEKLLRRNQFFMAEITKYAASLTNAAGGILEPETVFLKPEKHLGREPIVKRTIRVTETPRNKQLKVNGPKQGSHQKMVGSLVKNQATIQVQEKQHSAGARQLKAWGNKCQGFEKETSLTRRYLKAREYLVSLEKEKRYLVEVEVLTYQVSTLVQLWKKKCASNEQEKSLSIVALIWYAILQISKAKQGITDEVGRRIQDTINVFNLPAIDISPNSAGRLSFEFTSLASPKVKLETGLSPVEFQLIHAGPYFDRNMDSAPDARVHDFEPDRWQREILDQIDAKASLFVVAPTSAGKTFISFYAMKQILEDSNDGVLVYVAPTKALVNQIAAEVQARFSKSFKHVGKSVWAIHTRDYRINDPAGCQVLITVPHILQIMLLAPSNARSWSSRVKRIIFDEVHCIGQAEDGVVWEQLLLLAPCPIIALSATVGNPEEFKNWLSLTQKANGCDLKMIEHKARWSDLRKFKYNPPQAFVFKGLPNVTDMAALGLDGCPNMSFIHPVTSLINRSRGIPDDLTLEPRDCWSLWKAMDKYKTNKYPLDRDLDPSVALPTVISKTNVLEWEAKLKTVLKSWLNNLDSPFNAVLEELSPKYQPDNKFGVQISTGVLSESETPRKVRDTSILDTTLPLICSLHDQGALPALFFNYDRSWCEKICQEILSELQESEAHWKASSSAWTQKIAEWETWKKVEAKRAKQKLPTRKTGKGESMSKEEQMRDMTAEESSWHESFDPEEPDPRFSLADMKKLAPSEFEDYAEELRRREVPQWLIDALKRGIGVHHAGMNRKYRQACEILFRKGYLRVVIATGTLALGINMPCKTVVFSGDSVFLTALGFRQAAGRAGRRGFDFLGNVVFQCISHSKVCRLLSSKLPSLNGHFPITTSLVLRLFILLQKSEQAPFAVKAINSILSCPRIYLGGPDSKHTVLHHLRFSIEYLRRNYLLDTNGLPLNFAGTVAHLYYTENSSFAFHALLNDGYFHRLCKNISSNPNCVVLTLMLVMSHLFGRQYLRPSILERLRMSEKKPTSVVVLPSLPKHAAEILRSHNKKTLEIYSSYVTTFVEQHVKDPDCFLPLTQIKCGGDKSPDEISCLLPITPPTRVTSSFVALSGHKDEWRSISDLSQKVRSGVWLEWAVVPYVGLFPEEGKFALNAYLYDFFKHGNVEALEKENIIRRGDIWFVLNDFSLVLATIVTSFENYLKLSNNTDMDLLDVAGSGDNRELSLEDDAVDTGQSSPGKTTKTAGRISATMQSKPKTPISPGPSARPKKSKVADSWEDELSDEDPSQKDDEISKGSEKPIRTTNQLKGKGKNNVASAQRNSDSRTEFNEMEFLQVLQAFKMLQAEFNAKFKAMWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9E2</accession>
    <name>A0A317X9E2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_458467</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470998.1">
        <property type="nucleotide sequence ID" value="XM_025607793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9E2"/>
    <dbReference type="GeneID" id="37109936"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="26"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="216" mass="23701" checksum="84D46E6A0057736C" modified="2018-10-10" version="1">MTADKGPQITAVSWTFGGVATIVVIVRLYTRLLLTHKGGWDDVFIVLSLLSAIVCSGLAQVGVHYGLGQHMADIVDAEWRIEAYKYTVIAPNFSMVSTTTGKLSVVVFLLRLMGQTATPAKRWFLYIFSAISVAWNVLAIIAIMGFCRPPQKIWRPEVEGSCFSLEFQLVAGISQASFNAFADLTLAIFPILIFWNIQLPWKMKVGVLAVTSAGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9W6</accession>
    <name>A0A317X9W6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_225380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472105.1">
        <property type="nucleotide sequence ID" value="XM_025606253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9W6"/>
    <dbReference type="STRING" id="1450535.A0A317X9W6"/>
    <dbReference type="GeneID" id="37108396"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000031">
        <property type="entry name" value="BZIP transcription factor (MeaB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 60-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="309"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="608" mass="66618" checksum="1F844175B49121AD" modified="2018-10-10" version="1">MATLAEHPVVAPTSFEQDIESFLNLDQLAYTSAEPARAKTALVSQPTLPSTEFNAGDVRSAGFASTTAQQTPVAFQGPSHQYDEHKQQTGLPPGALAHAMTFNNHMNGMGYGAPSPGFAMNGDMYAGNQLKREDVPMDFNSPPMRNPSEMDLESDNMGPVPAYFISPNPSNKSQFVDPNALGGHEVVPASTQVGRMYPGMHQQQAAMAKAAQQQKHHEYLRQQHLQQQRRVEEHMHHNGTPHSQTPRPSNPAVDERISRLLQQMRQSASSPDDSPSPPSILPQMAKAKKDEQDMDEDERLLASEEGKKLSSKERRQLRNKVSARAFRSRRKEYIGQLESEVAAKTNEAHELRLQNRALFEENARLTDLARMLLSSPQFSQFVDEMGPNGLPLSSQMQAQAHPQHHQQHQQPQQQQQPQQQAPAMSQPPMQQAPQVSMVMVPNQGLDVSAMGLNNGGWNSGIDMNFGNASVFAVLEVPEPVIDTEALSGKSDSIMDSYLPSLPSSKDEAPVLESLPFVSEAEQKSDIGVENPDVEIDESDPAFALFAGLPAIPTSQWSGASIDGVLAEKSATVFELVVDSKDAAQRVAQLCHSMEAAFERVSMMTAHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9Y7</accession>
    <name>A0A317X9Y7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_272474</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471148.1">
        <property type="nucleotide sequence ID" value="XM_025606572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9Y7"/>
    <dbReference type="GeneID" id="37108715"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="87" mass="9466" checksum="E78105D5663DDA53" modified="2018-10-10" version="1">MDGPAWDSGDTLGHGEMGILMPIALPLSSLYYLRPSGSARSSSEKVRFRVLISKRGMEHMVSPPAPRTVDTSTSQSSGHNEIPLKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA70</accession>
    <name>A0A317XA70_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_621821</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470181.1">
        <property type="nucleotide sequence ID" value="XM_025617022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA70"/>
    <dbReference type="STRING" id="1450535.A0A317XA70"/>
    <dbReference type="GeneID" id="37119165"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="62"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="696" mass="77864" checksum="5F8FA3AE714AC348" modified="2018-10-10" version="1">MSVRPNAIPGIANISQPSPGMTPPRERVPRACEHCRARKIKCNGQRPCHACARHPERCLYRPGSIRQRKSRRAPDPARPPALLPLPATQSPTTPSDWSNASLSDDPIQYKRHHELRAGIGVQNPETGAFQFYGPSSGFCFIHRVYQRIKQGSSCEPLLARRSGAIPDAIQRFGMERFMFARTGDSDPRRTQWPSEMFLPRELGDQFIEAYFRVMHPQIPVLIQSEIVDAWTQMWESPVRDRGVKNQDILFMVLAIGARVANLKGKQSASSVEAWAEYFSSRVSEGPIFLQEPSIRGVHMMLLKSMYALQMMRQNDAYLYLGHATRTCLVLGLHRSQVTDGRDPNMHRLRLTFWTTFFCERISSLYMGRPSSLADRQIDTAYPEDLTYPSDGSHAPMQECAFIRAMAEISKLADRVSIEIYSPASIKCMADLAKLNQTSLECDAALQAINPTLPSYLHFFDDGVPIGEPWQEIQRLSIGFCYYVVRMLLYRPALVLTTFFSSVSEAQTATGCAELQACINASTSAACNLIHLAHDVYFRRFPDIRYDGALASFLISACLTLLYNVLNLGTDPERARKTFTVIEKAIKCLDEIEHTGYTSGKALSLDLMKVAKQAVYAADPVVDTNQVLMDEFPWLEDWASAVAREGNLDPSLYALPQAEMPVIGALEGNGAGWIESEGNYLWAGNGFAPNSMPGCFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAH2</accession>
    <name>A0A317XAH2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_315290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470709.1">
        <property type="nucleotide sequence ID" value="XM_025606851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAH2"/>
    <dbReference type="STRING" id="1450535.A0A317XAH2"/>
    <dbReference type="GeneID" id="37108994"/>
    <dbReference type="OrthoDB" id="5427664at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053018">
        <property type="entry name" value="Elsinochrome_Biosynth-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37577:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="316" mass="36373" checksum="435AE5B920A04298" modified="2018-10-10" version="1">MSDLQIATGIAILISGYAQLRCGISCYHWQFMGRLAWFSCLTHLSCLTLLRNYLHNHPSERHWRLVLMFALVVMLIVAIFPSGNYEWIWGYPVFHPSPSDHAICYFLQRPSIKTTAGISMSIYILTTGFGFLFRIVKLHKILSVYMVRRPRKSLSKWGRKGLWKIFMWRTAPNLSKRLLGNLLYLPLLSVFLVARVALDHWSSMYFEIYWLVMCFLFAIVQLIPTLELSDPTLHYYLDIYITHIGDKLGDLSIRVNSTAHNITIPEPDLDNIAGNRWGFGQIMPVVLLALPLLPIVEIFYPGRTARSIENIPLTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAL6</accession>
    <name>A0A317XAL6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_454982</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472206.1">
        <property type="nucleotide sequence ID" value="XM_025607627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAL6"/>
    <dbReference type="STRING" id="1450535.A0A317XAL6"/>
    <dbReference type="GeneID" id="37109770"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="273"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="360"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="432"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="557"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="631"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="669"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="680"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY95445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="751" mass="85133" checksum="070558A8D4497D2D" modified="2018-10-10" version="1">MVLQEGAVYCTLLLSDHYLPGATVLAHSLRDNGTKAKLVALFTPGSLQPATIQELQAVYDELIPVHPLTNVTPANLWLMDRPDLIATFTKIELWRQTQYKRIVYIDCDVVALRAPDELLELEVDFAAAPDVGWPDCFNSGVMVLRPNLQDYHALRALAERGISFDGADQGLLNMHFRDWHRLSFAYNCTPSANYQYIPAYKHFQSTISMIHFIGAQKPWNMARQVDPVHSPYNQLLGRWWAVYDRHYRPTVTLPIQPTQPSNIVPTIQVETPTPQEVPWDSQEDKQAQPHRDYQEHAFHDQATETRFEPPSQPHWQPQPPQEPQLGAPTPSYHGHGAQEAPQVHQIQEFYQELPQQSVPIPDQQHTTLTGLPQPTEDVQRQEQHASESVQAPIISAVPRYVRGEEHVTAYIHPHSGETSFVAHIEPPLHAHEASVPSTVSTISSESSYPQPHYPQHPAESIHSTEQPPAPPSPKPEVRTSFEPPKAEWDASKEPPPLNTKPEGIALAKKTYTMSQDEQLFQPPESYPEAPKNMYYEVPSTKPEPEKLTQLFPWETHAPTPTRVFPEDDQSSATFTLPRSFIESTEDEASPSPESRMKSWTSEEPTESWDTYSRSNAWDEVPEIQRYIQSLQQARKGRVQVLTGGPSSAGQSLPGQERFNYSWTNVRVTDFPSEEERPSLPVTPAPIRRQPPGPGEENSDLDLLPPAHGVPNQEDWNPTVGLEELRRYQSEVLENPDLLHERILTIRLRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAU7</accession>
    <name>A0A317XAU7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Replication protein A, subunit RPA32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_553576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471448.1">
        <property type="nucleotide sequence ID" value="XM_025613665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAU7"/>
    <dbReference type="STRING" id="1450535.A0A317XAU7"/>
    <dbReference type="GeneID" id="37115808"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000308">
        <property type="entry name" value="Possible replication factor-a protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000168">
        <property type="entry name" value="Replication protein A 32 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014646">
        <property type="entry name" value="Rfa2/RPA32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014892">
        <property type="entry name" value="RPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08784">
        <property type="entry name" value="RPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036949">
        <property type="entry name" value="RPA32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Replication protein A C-terminal" evidence="6">
        <location>
            <begin position="152"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="261" mass="27814" checksum="CB36DC3C162066EE" modified="2018-10-10" version="1">MNGEMNSPSGGKADYTNATLRPITIKQALDANQPYPEAPYQIDSAEVASVTFIGQVRNISSQSTNITYKLDDGTGEIEAKQWIDSMTADSMDTDDPTSNSTNKNQIELNGYARVFGKLKSFGNKRFVGAHCVRPIKDINELHCHLLEASAVHLFFTRGPSNPNSGEGAGGVKGGGDSAMGGVNGADDFAAAKGLPAMSPVAKRVYHLLKTEPQSNEGLHAQLIAAKLSLPMPDVARAGDELLTAGVIFSTVDEQTWAILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBL0</accession>
    <name>A0A317XBL0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NPP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_531926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Necrosis inducing protein (NPP1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470701.1">
        <property type="nucleotide sequence ID" value="XM_025611009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBL0"/>
    <dbReference type="STRING" id="1450535.A0A317XBL0"/>
    <dbReference type="GeneID" id="37113152"/>
    <dbReference type="OrthoDB" id="89086at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016392796" evidence="3">
        <location>
            <begin position="19"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="244" mass="26085" checksum="B94557FADD97EC50" modified="2018-10-10" version="1">MSLRTLLLAASTVCLAQADTRLHARDWIASSAIVGLDQTVPDDATGDLYLGYQPYLKVVNGCVPFPGVDAEGNTDAGLSPTGSTNGHCSSSTGQIYVRSNITSTSSTSDYPTALLYSWYMPKDEPSTGIGHRHDWEGVIIYLKDSTTISADNIIAVCPSAHGGWDCTTDSYSLSGTKPLIKYESVWPLDHSCGLTDEVGGTQPLVAWESMPSAAQDALQTADFDKAIVPFKDSTFEENLGKATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC00</accession>
    <name>A0A317XC00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_541012</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472925.1">
        <property type="nucleotide sequence ID" value="XM_025613026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC00"/>
    <dbReference type="STRING" id="1450535.A0A317XC00"/>
    <dbReference type="GeneID" id="37115169"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY96164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="251" mass="28476" checksum="85A7D4E287C1CA91" modified="2018-10-10" version="1">MKIRLPVLVKEEPKLVYHNEIRYVLKVLNRPLYQARDTDVFLKELENIKYFAGVSNIVQAAGVAVSTNHYMTSSRSDGPLVVTGILLEAYSGGSLRQILLENRVTQYPWKQWPVQIGTALNRFHKAKKTHMDIKSLNVVIDSEGNAVIIDISGIGGTTRSWCSPEIKNESSPFDLPFEQRRLNDVWAYGKLLSKIGLHTGDDPFATTLKQVADCLMNDYCQTRMSLTRAISRLEYIEVQDRLILPATYPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC09</accession>
    <name>A0A317XC09_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Uroporphyrinogen decarboxylase</fullName>
            <ecNumber evidence="4 14">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_530373</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the sequential decarboxylation of four acetate groups of uroporphyrinogen-III (octacarboxyporphyrin) to yield coproporphyrinogen-III (tetracarboxyporphyrin) with the formation of intermediate hepta-, hexa- and penta-carboxylate porphyrinogens in the heme biosynthesis pathway. Acts on a number of porphyrinogens, but only coproporphyrinogen III can ultimately be converted to heme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uroporphyrinogen I + 4 H(+) = coproporphyrinogen I + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:31239"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62626"/>
            <dbReference type="ChEBI" id="CHEBI:62631"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>uroporphyrinogen III + 4 H(+) = coproporphyrinogen III + 4 CO2</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="4 14"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472402.1">
        <property type="nucleotide sequence ID" value="XM_025610663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC09"/>
    <dbReference type="STRING" id="1450535.A0A317XC09"/>
    <dbReference type="GeneID" id="37112806"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000004">
        <property type="entry name" value="Uroporphyrinogen decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091">
        <property type="entry name" value="METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21091:SF169">
        <property type="entry name" value="UROPORPHYRINOGEN DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="16">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Uroporphyrinogen decarboxylase (URO-D)" evidence="17">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY95641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="363" mass="40743" checksum="3DE800A6DA206716" modified="2018-10-10" version="1">MQHQFEPLKNDLLLRAARGEKVQRPPIWVMRQAGRYLPEYHEAKAGRDFFECCRDPEVASTLTLQPIDRYAGLIDAAIIFSDILVIPQAMGMQVEMVDKKGPHFPEPLQSPDDGQYEKVMQKQVDVKSELDYVYKAITLTRHKLKGRVPLIGFCGAPWTLLCYMVEGGGTKLFVQSKKWIYKYPKETQALLQKIAEICVEYLALQVAAGAQLVQVFDSWAGELSPAAFKSFSLPYLRHISAHLPKKLKEMGLEPVPMTVFAKGAWFGLEDLCESGYNVVGLDWLHDPAEARCIANGRVTIQGNADPGVLYGGREAITEAVETMARGFEKGKQGWIANLGHGVTPFVNPDDLKFFFEEIHRLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC71</accession>
    <name>A0A317XC71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Carnitine O-acetyltransferase, mitochondrial</fullName>
            <ecNumber evidence="16">2.3.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_542020</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Carnitine acetylase is specific for short chain fatty acids. Carnitine acetylase seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(R)-carnitine + acetyl-CoA = O-acetyl-(R)-carnitine + CoA</text>
            <dbReference type="Rhea" id="RHEA:21136"/>
            <dbReference type="ChEBI" id="CHEBI:16347"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57589"/>
            <dbReference type="EC" id="2.3.1.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.7" evidence="16"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472696.1">
        <property type="nucleotide sequence ID" value="XM_025613069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC71"/>
    <dbReference type="STRING" id="1450535.A0A317XC71"/>
    <dbReference type="GeneID" id="37115212"/>
    <dbReference type="OrthoDB" id="240216at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000007">
        <property type="entry name" value="Carnitine O-acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF103">
        <property type="entry name" value="CARNITINE O-ACETYL-TRANSFERASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="20">
        <location>
            <begin position="33"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00073438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY95935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="610" mass="69421" checksum="5B450CB668FEFED0" modified="2018-10-10" version="1">MAPRRKASSVPEGYKEDLSKGKMLRFEDSLPRLPVPSLEETGRRYLKSVHAVVSEAEYERTKKAVDAFIRPGGEGESLQERLLARAADPNTKNWILEWWNHAAYLGYRDPVIPYVSYFYSYRDDRARRNPAKRAASVTTAALEFKRQVDDGSLEPEYMRGQPIAMSSYEYMFNCCRMPGDSVDYPQKFPAQENEHIVVVRKNQFFKVPLVVNGRRLNNTELERQFERIYEVAQPSPAVGVLTVANRDLWADARKKLLAAHPANKQALRDIESSGFVVCLDNATPVTLEERAHQYWHGDGTNRWFDKPLQFIINDNGTAGFMGEHSMMDGSPTHRLNDHLNNLIFNHKIDLSEQPVRSDLPDPRPITLHLDGPVLEAIDAANKEHRQQISSHELKVQAYQGYGKGLIKKFKCSPDAYVQMIIQLAYFKMYGKNRPTYESASTRKFQQGRTETIRTVSDDSVAFCKAISDPAVPREEAVRLLRTALAAHTKYTTEASDGRGVDRHLFGLKKLLREGEKLPALYEDPAFAYSSSWYLSTSQLSSEFFNGYGWSQVIDDGFGIAYMINENSLNFNIVCKRLGAERMSYYLNEAASDMRDMLMPDLAAQAEKAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCI4</accession>
    <name>A0A317XCI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_581754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472183.1">
        <property type="nucleotide sequence ID" value="XM_025615428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCI4"/>
    <dbReference type="STRING" id="1450535.A0A317XCI4"/>
    <dbReference type="GeneID" id="37117571"/>
    <dbReference type="OrthoDB" id="4802432at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="118" mass="13653" checksum="1ACEDAB8F947B94C" modified="2018-10-10" version="1">MPAINFLSSETDTLSNNLRGLTFRLRELKLKQTVLSLDWLFPLDEFCQPAPHTTGYYCPHLENISLYGVPEYLPSGDYLFHYPPAREAEYAAIEDWEEAICEMVDEQARLTEPIRQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCN5</accession>
    <name>A0A317XCN5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Component of the RSC chromatin remodeling complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_529674</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473040.1">
        <property type="nucleotide sequence ID" value="XM_025610501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCN5"/>
    <dbReference type="STRING" id="1450535.A0A317XCN5"/>
    <dbReference type="GeneID" id="37112644"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="8">
        <location>
            <begin position="107"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="380"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="381"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="575"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="286"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY96279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="680" mass="74096" checksum="8F35514A2DB7B961" modified="2018-10-10" version="1">MEDNSIMPGGAAEDAHALNLTQDAPGDVISTSDAPGSPKPHNDGEPEDEEMGGTETETKKETDGGDDLADVAAQSGAEGAAEEQPAQAKASVEASARSHLVSQTHAIILPSYSTWFDMHLIHPIEKKALAEFFNGRNRSKTPAVYKDYRDFMINTYRLNPIEYLTVTACRRNLAGDVCAIMRVHSFLEQWGLINYQVDPQTRPSNIGPPFTGHFRVVADTPRGLQPFQPGPNHFVKPGKPLPATDRAASATPATKADLNLEIRRNVYDDKGKEITPAADDKEKQTNGEGTANGTAGDATKAMESASKEPRKKFHCFSCGIDCTRLRFHYAKATPATANPAAPDTKYDLCPNCFLQGRMPSSHSASDFVKLEESPYTIAPDKEAPWSDSELVLLLEGLENFDDNWEQISTHVGSRTKEECVMKFLQLEIEDKYLDDMPEMRAANGREPISQTENPVLSVVAFLAQMAEPAVAAAAAGRSVEEIRKELRKQLEKGSGAQDKGKEKEGTAVKAEDSMDVDIARDDATEQSLEVAGSDKSKASLPTVALAASAARAGALASHEEREMTRLVSAAVNVTLQKFEIKLQQFNEMEEIIEAERRELELARQQLFLDRMSFKKRVKEVQDTLQAVSLRGPGEETNALLADAATAGIGNRYNFQPAGGDVRGVQPLSADTGADYKMLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCP8</accession>
    <name>A0A317XCP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_619529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473155.1">
        <property type="nucleotide sequence ID" value="XM_025616868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCP8"/>
    <dbReference type="STRING" id="1450535.A0A317XCP8"/>
    <dbReference type="GeneID" id="37119011"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="92"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="34"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY96394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="330" mass="35261" checksum="85343760CD2F35D5" modified="2018-10-10" version="1">MWVSLYFVTNHTLRDTILLSSILTPFTITPTNDHNNNNPSITSPPHHNHTTTSNHHQNALPNPNPPTLTSFPPPNPNHHPSLPQTPSPNTTSNPSPNVLLLLHPTGDTSTNLTPLAVALNLPETTTITLQAPTPLPFDLGGFHWGDDITFSPDGGLDMDAGFSRSVKVIHEVIRDVLVRKCGYKVRDVVIWGLGQGGMVGLEVARVLALKGVDGGDKDKDDGERCLGGVVSIGAPVGLDGGRSGSSSGGGVGKSKTPVLIAAGKEGDGTAVTAAGVRRTQEWFEFVEVVRYKRKGDGMPRNREEMTPIMAFLARRLRSYKGVPEGSVEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCV9</accession>
    <name>A0A317XCV9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_454209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472926.1">
        <property type="nucleotide sequence ID" value="XM_025607600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCV9"/>
    <dbReference type="GeneID" id="37109743"/>
    <dbReference type="OrthoDB" id="4471330at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="294" mass="33157" checksum="BAB12C9A63E24C42" modified="2018-10-10" version="1" fragment="single">VQLRDKLTQESNASSSERKPRILRMRCRNIILDGCLTCLQEQGLDIDVDMAKLAILVYSKRNLCHARVGDPAQPAKLRKATEQDKNQLPEVLPEEQFRNYNTWERILAIYGDSQGLISLRPGSRSDTVLPEPDLRLLPEDARRDAFKNKVSDDRIDATFQSINERIPVTFSPATGHTRTKHSVSDLIADVVSCRTKSTMIESTGHSRQSMNGSWPFFNLWSIVVFGNVEDVCTFREIYEDLAHMFAKDQAKGRKALRETQRMAHRARADLDRETGCRKEGVGGDGGEGEEGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDT8</accession>
    <name>A0A317XDT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_581068</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472673.1">
        <property type="nucleotide sequence ID" value="XM_025615367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDT8"/>
    <dbReference type="STRING" id="1450535.A0A317XDT8"/>
    <dbReference type="GeneID" id="37117510"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051400">
        <property type="entry name" value="HAD-like_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470:SF2">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46470">
        <property type="entry name" value="N-ACYLNEURAMINATE-9-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="399" mass="45151" checksum="E0A0A5835E875D65" modified="2018-10-10" version="1">MTRPVFIVRDPVRVFDSWKKLGWGDLYSFFICYRSLFKMLQASPVPQVVIYEQLVSDARGTVAALADYWDILFDDWCLEFKRPFGDYILNGDRDQSINQGTVPDGLFDRVKTHTHVEDFSGHGLLSALEIEHIEAEVGTLYLEAYGPRLGPVLTLLASKPWFGFDLDDTLHEFRKTSAHASFSVFEAIQAAHPDAKETIDDLEATYRDVLRSKTANAFTDGRTSEDYRRERFSHLLEAHGHEPSTETLEHLLVVYKNRLRAALTLKAGALHLLEKLKARGKGVIIVTEGPQDAQEWTIAELGLKPFIDILVTTNEVRKSKVDGLFTAVLEKYNIAPGDLVYIGDNKQRDIIPARAAGIDTVLYDEKSNCQFDDPHNLRLNSLPKLEYLVCVVHHGSWGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEP2</accession>
    <name>A0A317XEP2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_226932</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472189.1">
        <property type="nucleotide sequence ID" value="XM_025606268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEP2"/>
    <dbReference type="STRING" id="1450535.A0A317XEP2"/>
    <dbReference type="GeneID" id="37108411"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY95428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="596" mass="69037" checksum="6B5473F464BBF3B0" modified="2018-10-10" version="1">MSGRNAPRSKNGCSTCRRRKVKCGEERPVCKRCANLRLACEWGIPVKRGKAHAPVRHLQPAQPRWASDVITTTTCIPSDTPSPSYTDVSNGILHPHYATTLATLWHRQSPAAPDLTPVSPDVIFPTGWPFPPYPQPSPLYRPLSEPGLVCNNSLVLTEHDQKYFRYFPSSSVVYYYMKNWQWSSFRYLYEGPATTSKVIMRMILALSASDMHRNGLAVRSPGRPTAEDHGRYHYGMAVKEFRQLLETPKPQISFAELEMIFATMFLMVAYEWQFGHCMRHLHLHLQGVRSLLETHPELFHVRDVNEVLLAMEAEQPSDTVTRASFISDQFLLWILYIDVTRRSIGTTESLYDYVLNSDNESLHPDHLYRCARLWSRCFWGKQYPDQEVSDDMENYRALEFVHVGYTLWHKLWKCLDKSSTYTGDGLFTEMMTVRDVRIPLLYNSLLTVQKYSDLLLTAKFASPGSTRRTLNTIYLAVNNFYGQILFHRRLFDPVHPPTALHRQALTNIIDNAHKQYTADPRLLRRLHWPLLMAIVETDDPIQREWLRERLSEMRAFHSEHMWAFEIAEDVLAHQDPSIGEYANLAEVLRNHQISVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFQ3</accession>
    <name>A0A317XFQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_571180</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472371.1">
        <property type="nucleotide sequence ID" value="XM_025614859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFQ3"/>
    <dbReference type="STRING" id="1450535.A0A317XFQ3"/>
    <dbReference type="GeneID" id="37117002"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="695" mass="74814" checksum="3ADCEDDC35F47F84" modified="2018-10-10" version="1">MSSDTVTFTAPLSQGFGYGIIIGLGFAFALLMIFITWALKRYQHEVQTSEMFSTAGRSVKSGLVAAAVVSSWTWAATLLQSTTVAYEYGVSGPFFYASGATVQIILFATLAIELKRRAPNAHTFLEALRARYGTVVHVVFIVFCLMTNTLVTAMLLTGGSAVLTSLTGVNTVAACYLLPIGVVLYTLFGGIKATFLTDYMHTVVIIVVIFIFSFSAYATSDKLGSPGAVYDALVAASKLHPIDGNAEGSYLTMRSKEGGIFWVINLVGNFGFVTPTSPTISLLTIYSNSTVFLDNGYYNKAIAASPVHAFPGYVIGGLCWFAIPWLCASTMGLTALSLEGAQRLSSDDVTAGLVLPFAAVKLLGYSGAVCTTIMIFMAVTSAFSAQLIAVSSIFTYDIYQAYINPSAKGKTLVWVSHMSCVFWAVVMASFATGLYYAGIGMGYLYLLMGVIISSAVFPGAMSLIWKHQNWIAAAASPPLGLAVSLIAWLVTAKKEYGVLTVTTTGANYPMLAGNVAALLSPVVFSPVLTLIFGSQNYDYESMRAIRRVDDADVAAAAHVDIELIPGEINTQTAAQEEEEMRKLNRAALYSRTLTIAMVFCFLILWPIPMYGTSYVFSKKFFTGWVVVGLIWLFGTTFGVVIFPLYEGRASIVRTVKMMAMDLMGKGRGKAIMGEMTSENVSGVQTPVAEKEMMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFR8</accession>
    <name>A0A317XFR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4246 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_542061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472739.1">
        <property type="nucleotide sequence ID" value="XM_025613071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFR8"/>
    <dbReference type="GeneID" id="37115214"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="1">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="133" mass="15580" checksum="3AA5357EC33CD808" modified="2018-10-10" version="1">MDGPPMNNSGTGKLQVPGFGDLRVYHEVDPRRPLRSCCRSERDVTQSSEDTEDNHRFDIALAQFCYGYRLTICEVYMLRLMELVTEKPNWEHNVFDEHLVAQWYTEFCDLKMQSQSKPDSEVDMDLVSPRAWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XG74</accession>
    <name>A0A317XG74_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein kinase C</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BO94DRAFT_552682</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472621.1">
        <property type="nucleotide sequence ID" value="XM_025613615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XG74"/>
    <dbReference type="STRING" id="1450535.A0A317XG74"/>
    <dbReference type="GeneID" id="37115758"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11621">
        <property type="entry name" value="HR1_PKC-like_1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.160:FF:000004">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000191">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15 17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="23">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="REM-1" evidence="23">
        <location>
            <begin position="145"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="19">
        <location>
            <begin position="228"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="427"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="21">
        <location>
            <begin position="495"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="738"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="22">
        <location>
            <begin position="998"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="61"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="566"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="767"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="PWY95860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1063" mass="118841" checksum="07CF90713DE00F9D" modified="2018-10-10" version="1">MDGDDLIASVYRKIEREKALITAASNMRQSTDNPMVQQRVDANIRDGRKNIAYLEEKMRELQLRRDGGGSPTDKRLPPNPEAGPMTPQKDYPQGYGGNDEYGDGSGPYPHGGSGSMPSGAPYADPRPFAPVPKARPNYTKLDLIKYDTSYLGPKIQLMLSQLEFKLSVEKQYKAGIEKMVRLYQDEGDRKSRTDAEGRRIESNQKIQLLKQALKRYEDLHVDIESTDTPDDESLSTPNLRKPLTGLLTFRIHAVKDVDHATSSRFSRGPETFIVLKVEDTIKARTKATRIDRWQDETFTIDIDKANEIELTVYDKAGDRPTPIGMLWVRISDIAEEMRRKKIESEFNASGPGGPAGGSGQAYGDATGGASAGGQVMIDSWFALEPVGRIYLSMSFAKQLKDRRPFDIGLNRQGAVRQKKEEVHEKQGHKFITQQFYNIMRCALCGDFLKYAAGMQCADCKYTCHKKCYPKVVTKCISKANYETDPDEEKINHRIPHRFEGFSNISANWCCHCGYLLPFGRKNAKRCSECGLTCHAHCTHLVPDFCGMSMEAANQILETLIRTKHHKTASVSSGLSGPTLRPSGASRGSQDNPAMSYPQRPGESPYGAPPRQPSAEAVSAANNSYPPPQSPTAAARQPMPPRTSSSNAAVAAAAAATGMTPPQQTPVEQSRPMPPPLATYDPKAYEPYANAPQGIPPQIQHAPPPTYGVPTQDPMQMVPQKPAEVPQQQAKVRIGLDHFNFLAVLGKGNFGKVMLAETKSAKKLYAIKVLKKEFIIENDEVESTKSEKRVFMIANKERHPFLLNLHACFQTETRVYFVMEYISGGDLMLHIQRGQFGLKRAQFYAAEVLLALKYFHENGVIYRDLKLDNIMLTLDGHIKVADYGLCKENMWYGATTSTFCGTPEFMAPEILLDKRYGRAVDWWAFGVLIYQMLLQQSPFRGEDEDEIYDAILADEPLYPIHMPRDSVSILQKLLTREPELRLGSGPTDAQEVMSHAFFRNINWDDIYHKRVPPPFMPSISSPTDTSNFDQEFTSVTPVLTPVQSVLSQAMQEEFRGFSYTADFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGL5</accession>
    <name>A0A317XGL5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_552094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473229.1">
        <property type="nucleotide sequence ID" value="XM_025613575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGL5"/>
    <dbReference type="STRING" id="1450535.A0A317XGL5"/>
    <dbReference type="GeneID" id="37115718"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="2"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="308" mass="33952" checksum="D95F2E70931CA73B" modified="2018-10-10" version="1">MLPLPDLGPTDVLVIYHARSMNYPKVSTIIVANETFPWKCPDRVVVPGSDGASEMIGTGCRGSRFTVGDRVMLQHYPGFHDGPAPPADQKVPGTHMDGTFREHGVWEESALHPMPEYLSYEEAATLPCSALTAGSVLTQGTGGVPLFAIQLALKMGATVIATTSSEEGAARLRALGAHHKVFEIGGPGTSEQSFKCVSCGGKIDIVGFVTGRCYKEGLNLLSPLLYVYTVRGIEVGTQLEFKDMVRYMEAWKIRPVLDERRFALQDMKQAYRYFWEGKHFGKMVITYNQELDSVYRSQAATSRDHQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UT99</accession>
    <name>A0A317UT99_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_570406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000059">
        <property type="protein sequence ID" value="PWY65283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461408.1">
        <property type="nucleotide sequence ID" value="XM_025614808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UT99"/>
    <dbReference type="GeneID" id="37116951"/>
    <dbReference type="OrthoDB" id="5377226at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY65283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="267" mass="30094" checksum="88E72AA5DBC7161E" modified="2018-10-10" version="1">MNLPGYYSTNTVEDLMPHLPIDQRGSFVTSPSIRKRKREQVQADIVSTSSDRLVPSSIQYTNPQFRLDYPELSGQSRGVFTRQRCLHRKRRVQQPHTHRRSPFTENLSHTLQSNSSQTKISSQNIYVSAALEVNSPPVSPRTTSPNPYQQPQTLCASAFCLRSCHICHRKPTTREFIDAYADCDLCGQRSCHICLRYCDAIDCSGLVKMPTFNFQESANSDGMQTQRARKVCSACAVEGVTEAGMEVARCLECVRGFQPQFQAVHPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UW08</accession>
    <name>A0A317UW08_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_629231</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000057">
        <property type="protein sequence ID" value="PWY65636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461472.1">
        <property type="nucleotide sequence ID" value="XM_025617542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UW08"/>
    <dbReference type="STRING" id="1450535.A0A317UW08"/>
    <dbReference type="GeneID" id="37119685"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08588">
        <property type="entry name" value="PI-PLCc_At5g67130_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016255998" evidence="2">
        <location>
            <begin position="22"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY65636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="463" mass="50401" checksum="C348603C9602FAEF" modified="2018-10-10" version="1">MVAVTSLGLLLLLRGILHVGAKSTSEVTSISDLSSDLSSTSSSTDSSKHSSTDSSDSIIVVTTETAAAVPTGSYISYTTTITVADSITPTTFATTTAFNTTTSTNGTTTAATTTDTKVVVTGTRVDSSTSTATATTPANSQPCNGYTEFCSRQYSNITMVTAHNSPFVKKNNIAANQMYKVKTQLEDGVRMLSFEAHYYEDDIYLCHTSCDLLNMGTLETYLTTVTDWIKENPYDVVTILIVNSDYVSPWNFTSPIEDSGLIDYVYEPSIIPMSLDDWPTLSEMILDGKRAVVFMDYQANQTAIPYILDEFTQMWETPFSPLNTSFPCTVQRPPGITAAQAVDRMYMINHNLNIEIEFEGIDILVPDSAQINETNAVSGYGSLGLMANDCRAKWDRPPNFLLVDYYNDGNFQGSVFEVAAEMNNVTYNGKCCGGSKSAGTKMVDTSYMWLPVLTVVGLVTFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UWI8</accession>
    <name>A0A317UWI8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_332575</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461657.1">
        <property type="nucleotide sequence ID" value="XM_025606989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UWI8"/>
    <dbReference type="STRING" id="1450535.A0A317UWI8"/>
    <dbReference type="GeneID" id="37109132"/>
    <dbReference type="OrthoDB" id="5429740at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF163">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_8G05510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="40"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY66393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="363" mass="40847" checksum="1D84F2ACAEDCC93E" modified="2018-10-10" version="1">MSSPFGEPPKGLNLKESSTARNDAVVISMYMLAAVTICFRLFSRKMIQQAKIGLDDWLILSALLSGTANMACAIAGGHYGLGKHIWVVSIEDIVHMVHILYANVLLYILTVPLIKISIILSYRRLFGMQWTMWACIILSIGYWIGCTVAFLCSSRPISYYWTQYENPLGGHTVYKIYPFYIAHAVVNMAGDILILLVPIPLVWRLQLRTAQKVQILSIFLLGGFVCVASAIRIYYFTFVNDVDATWNLGNVFIWSSVEPSIGIVCACLPVLQPLFRTIINRHANAPKRAAKKGVRFAPDIMSKINGDDRKQRRDDEAVLTTTSIHVEMDSVGKGRISDEEDSIGYDLMSIKVQKDFQMEEEHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UXQ8</accession>
    <name>A0A317UXQ8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_504351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461640.1">
        <property type="nucleotide sequence ID" value="XM_025609505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UXQ8"/>
    <dbReference type="GeneID" id="37111648"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY66376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34973" checksum="60C293666924899C" modified="2018-10-10" version="1">MSKTTAEPSGDLSGTDGSHSSHSQETAKQERRRWQNRQNQRAYRERQRIRKQAERLAEEHALQQPNQVAAYVATQYPVPDLSILASLSREAGQNIGPIATTSCALAHPRIYRLLSVFEAAAYRSYHGNPQADHLLTLAKLNMFRAFVRNIAMLGYTREWMTDDALSRFSIHGPHPKLPVTTLPPSLQPTDLQRRQIHHPWLDFFPFARLRDNLIENEDCMDEAQFCRDLMGFWTVPGEHSCMLVWGDPWDPMNWEITEAFLQKWGRLVKGCPEILWSTNHWRRLRGEKRLVWKASFDTIAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6W3</accession>
    <name>A0A317V6W3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_590345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000040">
        <property type="protein sequence ID" value="PWY69836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462534.1">
        <property type="nucleotide sequence ID" value="XM_025616014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6W3"/>
    <dbReference type="STRING" id="1450535.A0A317V6W3"/>
    <dbReference type="GeneID" id="37118157"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY69836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="480" mass="53075" checksum="F96A0557EC935C4F" modified="2018-10-10" version="1">MSQDPDSQLSQGFLAPPAEITGPATPMLRASLSASPDLSVGAESQASHSDQSRSVSSPSLPSSDMTPPPSSQIPGAPRRRSRSCSSSLLASPPDIEKTLCVAYGASENLPTADDIDTADESKLRTIAKDLLGVAQEARMSALHFKLQNSLLSFTSNEAIKRAEVEHKLARREVEIIQSSEYRSRHCQPEIRKVQQISNVELELALKRNQELERVNTTLDRRLRRAKKLIEQERERSELLKEENNLLKGRIRDNRKHFSQMIEHCPMSPSPQAEVQVSHRRTLPQFADHNGHQMNGNDSHNPFAALLAADRVLNHESPSVTSTPHRPRTYKQHNDSHMRGSHSLSTLPLTPSRARMAHEGNQYNTPGRESHDGHRDRDSTISASDIEEAENEEDIPASEAGALASSMLRSHTFSNRRESRGPASAPKSSTLLQTKLFGQVKKAGVERPLNGLKRKASFDGATPKKAKAEERVGLGIDTWNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8F1</accession>
    <name>A0A317V8F1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_610974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462487.1">
        <property type="nucleotide sequence ID" value="XM_025616618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8F1"/>
    <dbReference type="GeneID" id="37118761"/>
    <dbReference type="OrthoDB" id="4509212at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="370" mass="40341" checksum="ADF6AD9FC44A1795" modified="2018-10-10" version="1">MSFLYLVDDTFERLPFTPSLPTTAEDKGSDKGKGPEEALSMEEAVANLTATLDASTMTATGDNLDVFNYGLSSTTEAPDASVQNKDRTEDDISHAETTSVDYMTPHDGDIDPTPRNVALNTNAPVTAEPNTTPGADATSREMNEDQDEPDTAPLLEDQGITPSTLFKATKPCKQGQDSTENDQAPSTSTPDNGLNKVDTRPDEGHHAILDRIDRRLTDAIPTAPLIPMSAACFSQYLRASKTMADETSPEVAPYASTVENKVSPTLDDPGASGVETPSAPSYLYDETKHQRLRLTYPRGTRSRVRVKAATPVLDAESVEKPIHDVNEEGGGSFLRDSESTRRIEIHYPKDDQAWVEFEGYGSQVEIIWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V946</accession>
    <name>A0A317V946_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_477092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462788.1">
        <property type="nucleotide sequence ID" value="XM_025608628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V946"/>
    <dbReference type="GeneID" id="37110771"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="97" mass="9992" checksum="F0579165155BDC19" modified="2018-10-10" version="1">MAPPAASLRVAGPHPCPFSPAAPLMIQFHPANWQIPFASTHPCAGPGRQPQRSPATAGAGHLPGPAVSAGRPAALALQVLRTHVACHRACKRSGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9F4</accession>
    <name>A0A317V9F4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_539968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462455.1">
        <property type="nucleotide sequence ID" value="XM_025612808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9F4"/>
    <dbReference type="STRING" id="1450535.A0A317V9F4"/>
    <dbReference type="GeneID" id="37114951"/>
    <dbReference type="OrthoDB" id="406733at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045582">
        <property type="entry name" value="Trehalase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF0">
        <property type="entry name" value="GLUCAN 1,4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19291">
        <property type="entry name" value="TREH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trehalase-like N-terminal" evidence="2">
        <location>
            <begin position="9"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="GH15-like" evidence="1">
        <location>
            <begin position="277"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY69627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="680" mass="76949" checksum="AD31ADD6D6FC9D2A" modified="2018-10-10" version="1">MDPINEYCGLEDYGLVGDMHTCALVSKNGSVDSMCWPVFDSPSIFCRILDKQKGGHFSITPHRSLKNPLSKQRYRPYSNMLETRWIHEEGVVNILDYFPIAKSKPHISEKGLPQWCRCHQPKVPGQYHACHSGLVRKAECVRGQMEIEIELFPAFNYARDSHTAYPSFTAGDGLQVYHFQAAAQNLQVSILEDKGDLHTDSSDFNIQLELSERAGHLGPGLVGKVTLKEGQSITLLLHDQESITSDVQVLAPYLQQIERITGDFWSDWTSKCTFRGHYREQVERSLLVLKLLTYKPTGAIVAAPTFSLPEHIGGSRNWDYRYSWVRDAAFTVYVFLKNGYPEEAESYINFIFERIFPPLNKKPKAGEPFLPIMVTIHGERDIPEMELDHLEGYRGSRPVRIGNGAATHIQLDIYGELMDSIYLYNKHAVEISYDQWLAIRRMVDFVIQIRHQPDQSIWEVRGPPQNFVYSKIMLWVALDRGVRLAEKRSNLPCPERARWVQERDALYDEIMTKGYNAEKGFFCMSYENQDAMDASVLVAPLVFFIAPNDPRLLSTIKKITDVPARGGLSVANMVSRYDTGKVDDGVGGNEGAFLMVTFWLVEAMMRAARSKAYLPHDPFFQQLRKTATSQFDSILSFANHLGMFSEEVATSGEQIGNMPQAFSHLACVSAAMNLGGGGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V9W7</accession>
    <name>A0A317V9W7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_539665</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462879.1">
        <property type="nucleotide sequence ID" value="XM_025612748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V9W7"/>
    <dbReference type="STRING" id="1450535.A0A317V9W7"/>
    <dbReference type="GeneID" id="37114891"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="456"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="543"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY71124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="644" mass="72787" checksum="24182E50EB2A76F1" modified="2018-10-10" version="1">MPLRESTVDNPKSPLRRCHHYIYIIAWALLSSIILYCAGRLSLVDALLLASGAATQTGLNTIDLNRLHVVQQATLLVVSMVTNVIFVHSLLVVVRLYWFRKRFQRAIHEAKMMCRAQRNTLNQRLADVENGTPRGFSRERPTEEVPLLSTVDEESSNESASVSPGGRKYGATGSTSPHITFCETEAEHEVKQRRRSYSGTWSRLSQPEIESPLRRSFSDLQNDMPPLPSLMWQSSIASYSDWNETQKEELGGIEYRALKTLVVILVCYFVVIHLLGVLFFVSWILPNQHYGQMLADNGISRSWWAIFTAGSSFNDLGFTLTTNSMASFNTAAFPLLVMTILIVLGNTGFPCMLRLIIWTLSQFTTYGSPLDDELQYLLDHPRRCFTLLFPSAETWRLAAVLLLINAIDLIIFYTLQEIPHPSPISASLRLVNGLFQIASTRTAGFTITSLGTLHPAVQVSFVGMMYISAFPIAIAMRKTNVYEERSLGIYNEDYDDHDKPHQSDSLGAHIQRQLGFDLWFVMLGFFFVAVAEGKRLQDNRTDLAFSLFPILFEIVSAYGTVGLSMGYPGTETSLCREFSGVSKVIVIAMQVRGRHRGLPHALDHAILLPCDLVEPDEEGRRPEWWWKRWIRKKSSDLGNFFTHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBE8</accession>
    <name>A0A317VBE8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_589958</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462944.1">
        <property type="nucleotide sequence ID" value="XM_025615985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBE8"/>
    <dbReference type="STRING" id="1450535.A0A317VBE8"/>
    <dbReference type="GeneID" id="37118128"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.580:FF:000003">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016612">
        <property type="entry name" value="Mediator_Med6_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013286">
        <property type="entry name" value="MED6_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0010">Activator</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="174"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="277"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR013286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY71546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="325" mass="35019" checksum="330736DB1662C613" modified="2018-10-10" version="1">MAGTPDASMEEILWRSPPHVQMMGGYLHSNNILFYFAESPFFDPTSNNASLAIQANYNEAFRHFVETREAFEGRLKTMQGLEFVVSYDPIQAAAQPDGRFAHDPSNIWVIRKQTRCKRAGQEDEVVVLSTYFIVGDCIYMAPSVASVVGNRILSAVTSLTSLLKTASTLPSFTPSHGHTYLPPAPKHADTSQPGTQSQQSKENTPLPEDAAGKASLVGSQVVSAGSSLQDTRTLAESFSLLSRYGDEFMDEHPLVGEPGSFILSRVNDTDRTSTAKQAANVGTAAGKVGTPQVKADTPGRASEKGATLSGTDESKMRKKKARLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBR6</accession>
    <name>A0A317VBR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_266872</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462723.1">
        <property type="nucleotide sequence ID" value="XM_025606529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBR6"/>
    <dbReference type="STRING" id="1450535.A0A317VBR6"/>
    <dbReference type="GeneID" id="37108672"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="199"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="403"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY70829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="573" mass="63559" checksum="8E4881F5CC93BB45" modified="2018-10-10" version="1">MPSLKIAEYLFRRLRQLGVDSVHGVPGDFNLTLLDYVEPAGLRWVGNANELNAAYAADGYARIKGIGAVVTTFGVGELSAVNAIAGAYTERAPVVHIVGTPSRELQAGRKLIHHTFNDGEYGRFAQIHAQLTVAQASLRDPRTSPEQIDEVLRQCLLHSRPVYIEVPVDMVDQYVADDRLGVAISQPEVVPSQTQDDVVARIVERINSAKQPIIVVDGEIRPLGIVDEVQKLVNATNWPTWTTVFGKGLLDETAPNVHGIYRGTYEPAEVQEFFNSADLVLCFGPHFSSTNSYFYTTIPNPENAILFTDTEVKFGTDIVRDIPAKLITHLLLQNIDLSRIHHYNPYPSLPRDQLLSFSDVDGSKPITQDKLWRLFANFLRPGDIVLGETGTAGYGVREMALPPHTRIFAPVTWLSIGYMLPGAQGAALAQEELMASSKYHGIKDARTILLIGDGSFQMTAQELATIINHKLNVVVFLINNDGYTIERCIHGRKQRYNDVPRWRYLQAPSFFGASEDTFTGTARTWRELEDALSSEAVSNGKELRMVEVFMDREDAPTGPLSMLIEKQQASDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCX2</accession>
    <name>A0A317VCX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Importin beta-5 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_525785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463166.1">
        <property type="nucleotide sequence ID" value="XM_025610324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCX2"/>
    <dbReference type="STRING" id="1450535.A0A317VCX2"/>
    <dbReference type="GeneID" id="37112467"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000373">
        <property type="entry name" value="Importin beta-5 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="23"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY72213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1037" mass="114369" checksum="FFC0E89C4D0EC358" modified="2018-10-10" version="1">MEQELLTLLADTQSPVADTRKAAELRLKSFYPDESFPLTLAAIASHNSVPTNLRQSALSVLRAFIADAWSPVLDEHKGQFLVNDENKAQLRRVLLDLATVADTPERKVKSAASVIVSKIASADYPEQWPDLLQSLLQTINDVNCTTSALHGALKVLLDLVDTGFSEDQFFDVARDLVSTLFNVATNQSRKPMLRALAVAVFRACFDTLEMVLEQHKVDVKQFMDEVHGNWSPFFLSTLKAPLPQAPSEQESKDAEIPSQWRGVIGLKLQVVKILMKIRMVFPGLLTAQSPQYFSTIWTELSNIQSTYHEFYIDDERQGRLEDVDGLPYTLDFLVLEELDFIQMLLKAPPVKAELQQQLQNAGPSAATASWLPEIMRLAGSYAQITSEEEGLWGVDVNLFLSEETSVTANYTPRTCSGDLVVKIGEWLKNTTVEGLHAYLNALFSDPSSTWRSKESGLYILNQLLRDFSEVSQQIPSELVTGFSNIIQYSIQQEDEYLRARGYLVAGILCQVADTSFQQTAVSYLEATLKTISEDASEVVKVSCIRSLQDLMPSLPPSATVHLQAAVISALSEFVATQDFSELSDSDDLKVTIAETLRDTIMVNPNVVLSSAAIDVLFAVASNGATNFQLTMIVTEAFEDIVESIAGGGQENFVRLCEKVLPSLTGAIDVGNLTQENALTILAADLLRALAEGALEPLPAGFVETVMPKLSRLLLDSTEADLIRPATEAVRNMLSHDFNQFITWRDPQSGKEAIEITLIIIDRLLSPSIDDNAATEVGQLAAELVEKARSEFLGPYLPQLLQAVARRLATAEQAQFIQSLILVFARLTLISAAEVVDFLAQVDIRGQPGLPIVLSKWLENSVNFAGYDEIKQNIFALAALYSLGDPRLFQVQVKGDLIIQDTGRIKTRSQTRNNPDRYTMVTAPLKIIKVLVEELAAAFGSKELDAATAAALEEEGSDDDEWEDMPGNTLDLNLGITKQELMAFGEGGSESVFGVRKRDDETQEFLLGFFRKAGSTPEFQQLYDGLTQAEKEKLQSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDT5</accession>
    <name>A0A317VDT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_261007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462997.1">
        <property type="nucleotide sequence ID" value="XM_025606492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDT5"/>
    <dbReference type="GeneID" id="37108635"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY71599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="182" mass="20719" checksum="0AE9E5F945FE8C1B" modified="2018-10-10" version="1">MPWPTLKFRVESTGIVGNFVRIQGAPFLELILDSRQNLRGRSPVDPKPWGLLLGLGNLSYLIPTEVPTDASMSRSLDFPGQDRLFPGSYGAIISSVLFFLISSIGRSDGKGLNRWRIPTRWVSSKRYSVLRTKRSFRWVLVETQFDPGLWSLGRRPLGYFYNRLYHTGEMCYFFGYQAGSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VE38</accession>
    <name>A0A317VE38_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_589944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462929.1">
        <property type="nucleotide sequence ID" value="XM_025615984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VE38"/>
    <dbReference type="STRING" id="1450535.A0A317VE38"/>
    <dbReference type="GeneID" id="37118127"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="571"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY71531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="607" mass="65302" checksum="B6D4277454D96B87" modified="2018-10-10" version="1">MSHITFSNSESRSGNYHAPRDSLELASLASSPDSAPRSSRFSSPSGISSSRKLSLEDEDPLTGSHSQTQMTSGRPRSARSYSISSAFDFGATLFPLSQTTGGYAPLGVSSADREAGVADGSLERNKTLTYLNGLSLVIGLVIGSGIFSSPSQVNANAGSPGASLIAWVVAGLLAWTGAASYAELGGAIPLNGGSQVYLSKIFGELAGFLFTWCAVLVLKPGSAAIIAIIFGEYVVRAVVGADVETINPWINKAVAFGGIFVVTLLNCISTRVAARIGDLFMFFKFVALLGVAIIGIIVAVTGHSSNGSANKEWKAGWFEGTNLDVSAWAVALYAGLWAFDGWDNTNYVTGEFKNPNRDLPRVIHTAMPVVILCYLLANVSYILVLPHSTIEASNTIAVQFGDKVFGSVGALVFALVVSASCFGALNATTFTSGRLVYAAGKEGYLPSIFGNLWTRNTLANRLQRRSWVSKSLSRLCGDGTRIGFTPINAMALNSGLTIVYVIVGEFKTLVTFYGVAGYIFYFVTVLGLIILRVREPYLHRPYKTWISTPIIFCCVSLFLLSRAIIAEPLQTLIVVAFIVAGVPVYYWRIYKRDGQKAFPNWKFWQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VF64</accession>
    <name>A0A317VF64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_569086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463299.1">
        <property type="nucleotide sequence ID" value="XM_025614720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VF64"/>
    <dbReference type="GeneID" id="37116863"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="20"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY72525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="544" mass="59339" checksum="A8432D99B9907EDC" modified="2018-10-10" version="1">MLLTLQRRPTTSDNKFPTVQLFLLAICRVAEPIALTSIFPYSWVMIRDFDVADTNSASFYAGILVSAFSLAEALTGMFWGSLSDRVGRKPVLITGCFGTMLSLLIVGFASNFWVALSGRVLGGILNGNIGVIQTMVGELVKRPEHEPRAYAVMPFVWSIGTIIGPAIGGLLAKPAEGFPFLFSPNGLFARFPYLLPNLVCSVLLLCSIISSWFLLNETHPDMQPWSVPDDLDDPVVERPLLTTAGVKANAGADLRAESYGTFNQVHLRDGENGTVCADDSKPESTPPKQNVFTWRVTMLIIALAIFTYHSMTYDHLLPIFLQDKSARSISTLSNLTLRFQGGVGLSTRTVGLIMSTDGVIALIIQSLIFPVLARRFGVWKLFVVVTILHPLAYFMVPFLIFVPGNYMIFGIYTCLVVRNILSIIDYPVLLILIKQASPSDSVLGKINGLAASAGALSRTMAPPISGFLYSTGAMIDLTALAWWGSTFVAIIGAVQLCIIEPKKHTSVTVHPAAHCLYTLHVTPYEEETVRIIVTNADSEEVDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VF94</accession>
    <name>A0A317VF94_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_539261</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463082.1">
        <property type="nucleotide sequence ID" value="XM_025612666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VF94"/>
    <dbReference type="STRING" id="1450535.A0A317VF94"/>
    <dbReference type="GeneID" id="37114809"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000130">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="175"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY72129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="252" mass="27329" checksum="380B70A971EE55C9" modified="2018-10-10" version="1">MSPPAIIAPSILSADFGTLGSECSTKITQGADWLHVDIMDGHFVPNMTFGAPVVTQIRTHVARPTEPNGKGTFDCHMMIQEPHKWVKEFKSAGCDLYCFHYEAAISSVAATSPADTTTTTKTSPKDLIRYIHEEGMQAGIAIKPDTPVDVLWDILANENEKERPDMVLVMTVHPGFGGQKFMASELPKVKALREKYPDLNIEVDGGLGLYTIDQAAEAGANVIVAGSAVFGAQDPADVIAKLREAVNNYRKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VH44</accession>
    <name>A0A317VH44_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspergillopepsin-1</fullName>
            <ecNumber evidence="4">3.4.23.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aspergillopepsin I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Aspergillopeptidase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_501404</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity. Generally favors hydrophobic residues in P1 and P1', but also accepts Lys in P1, which leads to activation of trypsinogen. Does not clot milk.</text>
            <dbReference type="EC" id="3.4.23.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.18" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463175.1">
        <property type="nucleotide sequence ID" value="XM_025609431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VH44"/>
    <dbReference type="STRING" id="1450535.A0A317VH44"/>
    <dbReference type="GeneID" id="37111574"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF23">
        <property type="entry name" value="ASPARTIC ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 18" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016310982" description="Aspergillopepsin-1" evidence="16">
        <location>
            <begin position="20"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="17">
        <location>
            <begin position="107"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="15">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY72222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="424" mass="44934" checksum="0EB5DDE4E57DEFFB" modified="2018-10-10" version="1">MQLLQSLFFALFFSYGVLSLPHGPGAQHKARSFKVERVRRGTGALHGPSALRKAYRKYGIVPSNLGIDLVDFEPITTTHTAVAADDVSEPDQTGAVSATSVEDDAEFVSPVIIGGQKVVMTFDTGSSDFWVLDTRLNKTLPGHTEYNPSNSSTFQEMDGYSFNVSYGDSSYAAGPVGKDTVNIGGAVVKDQAFGIPTEVSESFIEDTNSNGLVGMGFSSINTIQPEAQNTFFANVAPSLDVPVMTASLKSDGVGEYEFGVIDSSKYQGSIANVSVDSSNGYWQFSTPQYRVADGDLKSIDKVNTSIADTGTSLMLLNEDIVTAYYAEVPNSTYVDSVGGYIYPCNTTLPSFSIAIGSSSLATVPGNLINFSKVGTNTTTGQALCYGGIQSNGGTSLQILGDIFLKAFFVVFDMRGPSLGVAAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VH49</accession>
    <name>A0A317VH49_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_539165</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463265.1">
        <property type="nucleotide sequence ID" value="XM_025612644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VH49"/>
    <dbReference type="STRING" id="1450535.A0A317VH49"/>
    <dbReference type="GeneID" id="37114787"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY72491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="72" mass="8040" checksum="5559416F072CC6F4" modified="2018-10-10" version="1">MPAGIFNSTYYGKDYRAGAALLRARRPYLFRNALTGLALFGFTVSVYTYTIRAVGQDEFSDVKVPDNPAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHH4</accession>
    <name>A0A317VHH4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative proteasome regulatory particle subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_538804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463515.1">
        <property type="nucleotide sequence ID" value="XM_025612564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHH4"/>
    <dbReference type="STRING" id="1450535.A0A317VHH4"/>
    <dbReference type="GeneID" id="37114707"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="8">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY73763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="291" mass="32871" checksum="03B977AA46FDC61F" modified="2018-10-10" version="1">MLRHGRAGVPMEVMGLMLGEFVDEYTVRVVDVFAMPQSGTGVSVEAVDPVFQTKMMDMLRQTGRPETVVGWYHSHPGFGCWLSSVDINTQQSFEQLTPRAVAVVVDPIQSVKGKVVIDAFRLIQPQTVVMGQEPRQTTSNLGHLNKPSIQALIHGLNRHYYSIAINYRKTGLEENMLMNLHKHVWTEALQMKDFHEEGEHNVERMRQLVSLAEGYEKRVKEETTLSKDQLKTRYVGKVDPKKHIEDVSQQLIEDNIVAVSRQMIDKEASVARLSNGTEAENGTGMEVDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJT6</accession>
    <name>A0A317VJT6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_474805</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463807.1">
        <property type="nucleotide sequence ID" value="XM_025608529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJT6"/>
    <dbReference type="STRING" id="1450535.A0A317VJT6"/>
    <dbReference type="GeneID" id="37110672"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000044">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="26"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY74614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="717" mass="79802" checksum="1C911ABF7F45F6C6" modified="2018-10-10" version="1">MFLSVVPYTAQYGSPFSRTKQGKVAELRQELNSGGKKDKNHSAKKIALKKIVANMTMSNNDMVALFPDVIGCMNLPSLEIKKMCFLFLVNYSRLKPEIALKALPILIDDMDDTNPLVRALALRTISYIHVREFVEATVQPVKRLMGDMDPYVRKTAAFCVAKLYEHDKKMVEASDLIDRLNSMLKDENPTVVSSVLASLVDIWGRSESISLTIDYTSASKLVSILPDCSEWGQSYILEALMSYVPQDSAEALLLAERIAPRLSHSNSAVVLTAIRVILYLMNYIADERHVTSLAKKLSPPLVTLLSKPPEVQYLALRNAILILQKRPEVLRNDIRCFFCNYNDPIYVKVTKLELIFMLTTKENISVVLAELREYATEIDVHFVRKAVRAIGKLAIKIESAAKQCIDTLLDLVNAKIPYIVQEATVVIRNIFRKYPNQYENIIGNVIQNIDELDEPEAKAAIIWIIGQYADRIENSDGLLQDYLATFHDETVEVQLALLTATVKFFIQRPTKGQQLVPQVLKWCTEETDDPDLRDRGYMYWRLLSTDPATAKQVVMGEKPPISAESEKLDSRTLEELCLNVGTLATVYLKPVQQVFRSARTRRLQYSPALQKPQEDPGNAVWQFPAPSQSNSPTAAMAASAFPPTAAPGDMNAAVNAADSYFNSVGSQQMAALDLGGREDGSGGGGALQTQYVVNQNQQQVYQPQLAGGAATGELLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJY9</accession>
    <name>A0A317VJY9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_589800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463173.1">
        <property type="nucleotide sequence ID" value="XM_025615967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJY9"/>
    <dbReference type="STRING" id="1450535.A0A317VJY9"/>
    <dbReference type="GeneID" id="37118110"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000721">
        <property type="term" value="F:(R,R)-butanediol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034079">
        <property type="term" value="P:butanediol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08233">
        <property type="entry name" value="butanediol_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF23">
        <property type="entry name" value="(R,R)-BUTANEDIOL DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="8"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY72220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="369" mass="39541" checksum="71AC3075BBB71866" modified="2018-10-10" version="1">MRAVRYHGPRDIRVEEVEEPVCEVEEVKIRPAFVGICGSDIHEYLHGPATVPCTPHPITRQQMPVTLGHEFSGTIVEIGKGVTRAKVGDQVAVKPDLFDGGCAACLRGWVNCCRNLGFVGFSGSAGGLSDYVVVKEEQAIQLPEGFPLDLGALVEPLTVAWHVVNRCSTQDARTALVVGAGPIGLAVLLVLKARGMESVVVVETSPERRELASILGATHVLDPQTEDIVAAVRAMTGDAGADVAFECSAAQAGLDTAVKGIRARGTVTIVSLYGEKPVIDALDVVLREKHVVGAVIYEDGDFEAVIEAIWSGQLNPRPLITNKIRMEDIVDKGIKALIGGRDKQVKILVDISLKSEAEGRTVRHDQLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKR3</accession>
    <name>A0A317VKR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_500367</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463573.1">
        <property type="nucleotide sequence ID" value="XM_025609412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKR3"/>
    <dbReference type="STRING" id="1450535.A0A317VKR3"/>
    <dbReference type="GeneID" id="37111555"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001167">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="482"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="838"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY73821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="968" mass="108084" checksum="C1D21FD9BBDA1D2A" modified="2018-10-10" version="1">MEKAIRWSPTSTTAEQRFLSVDVVGKAFRLCKVTSFDGGRRLEQEVLSTHTKVPAFRAFDWSPVDESLVAVGQSSGDATILRMNSETQDSFSFPIRHQRYCNAVAFSTHGLLAAGLDRVRNDFCLNIWDVNQRLTSKAVKGFVEPLRKLASSEPITSVKFFTDQPDTLVTGVKGQFVRIYDLREGPGNPSLQFPTRCVHNVAIDWLDQNYIASCQATNDPTICIWDRRIGSRFITPAVGPTNAMETGQLGPSLEFGSVIAPKSTIWSLRFSRTKRGCLGVLSNTGHFKTYDIVKEYLDEEMRSSMDETLGQGSAKNYPEQIYTKYVRDVVTPYNHPSRGYDEKDRVVAFDFLNMSPGNEPSAITISGNDELSILTAKPPAPPVRLSSQGTLIWGSPDEDSDFRMITPPSSQGSSISKVVEDLRERVSDQNGAASQKGRRAAHRPATPLSSREAREHALSLGALGSRLPMEDALTLLSVNRLRCKEGYLFDEARNKRVIADDPWLQSFWDWVERARSDSSDESMVINGLDLNYLGIYNVWNNDLGESLEGRRVGHNPAVNIHETILELVQEQLNLPETKGCETEYAEHRRLCLRLCGAAQSHRELEELVKTLSADKQHTKAAALAIFQDEPKLAYLALRSHEPTQAHKLLAMAIAGAAKGDTDSDWEDTCAEIAKELTDPYARAILALVSKGDWRSVIQETTLPLRYRIEVALRWLPDDDLTSYLQTTTTSAIQQGDIEGILLTGLNHSAMDLFQSYINKFHDIQTAVLAMSHTVPRFINTSPDRARFESWRETYRQQINAWKLQLERARFDVGSRKFAVTWDGRKLFDPPRQQVSLTCNYCTRPLTQHDASSQLAPSVTGEVVHPTPGNPLGSAAMSGTVCPRCGRHMPRCGVCTLWLGAPDPMSKACVAADAAASAERRRPSEADLMRRFIVFCINCNHGFHAHHAREWFGRHKVCPVAECSCICDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNS7</accession>
    <name>A0A317VNS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_524111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463876.1">
        <property type="nucleotide sequence ID" value="XM_025610245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNS7"/>
    <dbReference type="GeneID" id="37112388"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY75249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="231" mass="26867" checksum="6653B880EF0CABC7" modified="2018-10-10" version="1">MAAPQFWLYAQSRLNDPTVKDETFRKWYQEYHLPDVLRTGSVSRGEFYQAIHPDKQYRWLAAYRCDDLDFMQPESLAKIPKTHTSLGTTKSCMEIAEFDTRLFQQSFVLKNGEGNENGITGPDRYLLTCSFHCGSDDYKELERQCVDGDILHAIPGSRWLKISRPLEDEDTYLGSMIVQGLDEVDEEDLGHLEEDWRSHLAQTLGLQRQFLQPHLWELLKSHDTDDSWSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPT8</accession>
    <name>A0A317VPT8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_538592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463908.1">
        <property type="nucleotide sequence ID" value="XM_025612526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPT8"/>
    <dbReference type="GeneID" id="37114669"/>
    <dbReference type="OrthoDB" id="4390692at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY75281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="139" mass="15705" checksum="96AB388390A3DDFC" modified="2018-10-10" version="1">MESYELPPEAEAIRKDIRQMVSEADTVSNKQDKSNSITIMEDEMGNKTYLGASLTEEITRLIEIMRIGRGWGYRLVNFRHHSVLPIKQGQGYLIPLSEQIMTAPGGILQEGFYKIIVNELTISAGAIAIFILPYELCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQE8</accession>
    <name>A0A317VQE8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_605660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463904.1">
        <property type="nucleotide sequence ID" value="XM_025616499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQE8"/>
    <dbReference type="STRING" id="1450535.A0A317VQE8"/>
    <dbReference type="GeneID" id="37118642"/>
    <dbReference type="OrthoDB" id="4494329at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY75277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="144" mass="16436" checksum="B7CDD9B55829B090" modified="2018-10-10" version="1" fragment="single">VSLLYCHASHHNPFQTRERVSVYDFVEYLEQAGTEKLDVYDYTIDDPNQRTKAMAIHDVIAYFKKPADQRTALNFLDIENRRGDYCPTPIILHSLLSSLSQLSSATHNDRGMAKTNSTWTKQLREFFLLSSKNAISQIHADTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQW4</accession>
    <name>A0A317VQW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_524180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463925.1">
        <property type="nucleotide sequence ID" value="XM_025610250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQW4"/>
    <dbReference type="STRING" id="1450535.A0A317VQW4"/>
    <dbReference type="GeneID" id="37112393"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015:SF22">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21015">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--N-ACETYLMURAMYL-(PENTAPEPTIDE) PYROPHOSPHORYL-UNDECAPRENOL N-ACETYLGLUCOSAMINE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="2">
        <location>
            <begin position="305"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY75298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="446" mass="48378" checksum="F1B1223C540B5F73" modified="2018-10-10" version="1">MAPKPLPLVIIACPPEHGHTLPLLPHATHLSQQGYEVHFIAGSALQDAITQTGANFHPVQTVITDEKLEQIRAIPEGPDRLIHAMKVTFLDLIPESSKSLKAVLEKLREEQPGREIVIVQEWVSMGTMPFVLGAPLPKGFDKLPPVISFTTVPLTVSSIDTAPFGPGLPPDSSEEGRARNIAMYKGAADTLDLEINNYINAVVANLGATEQITEPFFNNCLVGADLLAVPYNQTLEYPRSDLSPKVRFIGATPRKPLNPSIPVPEWWGEVLEAKQGANPKKVIFVSQGTFILDYRMLLIPSIEALAARDDCLVVGVLGQKGAKLDGVTVPANTRIIDYLPYELILPHADVFVCNAGFGGFLTSLMHGVPMVLAGEGQDKAEVAMRGEYAGVGVNLRSATPSQEAIQKGIDDVLTNKAYKTRCLEHQAENEKLNGLVQLEKLIQGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRD9</accession>
    <name>A0A317VRD9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_227112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. Involved in cell wall morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463663.1">
        <property type="nucleotide sequence ID" value="XM_025606271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRD9"/>
    <dbReference type="STRING" id="1450535.A0A317VRD9"/>
    <dbReference type="GeneID" id="37108414"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF9">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9 12" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016194219" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="11">
        <location>
            <begin position="367"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY74470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="525" mass="55724" checksum="34E6E14648FFE36D" modified="2018-10-10" version="1">MRLLPVAAGAAFFASSALAVDPIVIKGSKFFYSSNDTQFFLRGVAYQQSDTADPLSDKTTCERDIPYLKELRTNVIRTYAIDPTANHDDCMELLADAGIYVVSDLSNSTVAIDRSDPAWQLTLYDRYTSVIDALAGYNNTLGFFAGNEIANSVGTTDGMPYVKAAVRDMKSYISSQGYRSMGVGYATADVASIRGDLADFLNCQSEAVGIDFFGYNIYSWCGNSTYSESGYKDRTEEFANYSVPVFFSEYGCNSVTPREFTEVKALYGDEMSQVWSGGIVYEYFQDTNDYGLVSVIDSTSVSKMTDFTYYSNEIATASPSSTNKASYTPTNTALRSCPTEDSSWEAEATPLPPTPNDNLCECMVSAATCTVDDSVSSDDYGTLLGDVCGDITCSGVDGNGTTGDYGAYSMCNTKQQLVFALNYYYEVQSASGYAASACSWGGSATTKSATSATGTCKTLMSQAGTAGTGTVTSEVTATGSSSSATATSGSSSSTSSASQSVNVGSLQLVFYTAIAVVSGLGMIML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSS9</accession>
    <name>A0A317VSS9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_538411</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY75982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463979.1">
        <property type="nucleotide sequence ID" value="XM_025612483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSS9"/>
    <dbReference type="STRING" id="1450535.A0A317VSS9"/>
    <dbReference type="GeneID" id="37114626"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY75982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="162" mass="17672" checksum="3AB1FA248CCEE2D9" modified="2018-10-10" version="1">MSSTSVSECANCGAEATLQCAGCREAPEYQPGDAGGVYYCGRDCQKKHWPSHKPRYTAMRGRKKLLRAALVLKAAFLSYRQMVFDIQLTTIEVRAGTLHLHQILRAPTTLHKPGPFPDHLTTNAEHREAALTVNQRTLAMALLGPLTRKLLAGCRSAGGIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUF1</accession>
    <name>A0A317VUF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_588317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464526.1">
        <property type="nucleotide sequence ID" value="XM_025615877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUF1"/>
    <dbReference type="GeneID" id="37118020"/>
    <dbReference type="OrthoDB" id="5416097at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25829" checksum="E9E9840586354CAD" modified="2018-10-10" version="1">MRASESTSKNTNGGIVIAKSLCRKRDQDTCLITYLREPIEVAHIYPFSLGKKKTSGGPYVTFGPRRGSTDGKRKSQDRNLWEKARFALRPMCISDDQKVMTAEFFWLPGHKRSGYKAIDEPPVAFSSDLTACTVEEIERAKLFDMRTKSEINSGDALTFSTREPVKYSLPSIELLEMQWTLHRVLALSGAADVTDEDLDPYIRMGLGLNIVGEGEEEEDIKDVEMRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUH9</accession>
    <name>A0A317VUH9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450 2D18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_473290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464321.1">
        <property type="nucleotide sequence ID" value="XM_025608471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUH9"/>
    <dbReference type="STRING" id="1450535.A0A317VUH9"/>
    <dbReference type="GeneID" id="37110614"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF2">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALNH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY76508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="514" mass="58554" checksum="42B0F764017C45C5" modified="2018-10-10" version="1">MRGTFPGSRGRGLPPGPPCIPLIGNVLQLPTTGIHLKFTEWAKAYGPIFSLKIGSSTTVVINSPPLVKHILDKQSAIYSHRPNIYIARELILRGDHMMFLNLGDAWRRGRRLYHQQFNETRCEKQHVILQNAEAIQMLRDFCLSPEALMSHPKRYSNSIMMSIVLGIRTMTPDTAHMRGLYHFLEGLSEILEIGATPPVDIFPIFKYLPESWFHNWKSRSRAVGALLTRLYEPLIDHVIRRRNRVGSKECFLDNVLDQQEKLGLSDRDILLMVGNLLEGGSDTTASMLLIFIQAMLKYPDIQTQVQAQIDSVVGEDRSPTWDDYARLPMVAMVVKECLRWRPVAPTAFPHAAKEDGEIDGMRIPKGSTVVLNVWGLHHDPDRHADPDIFNPWRYADRTLPAPCYASSPDYENRDHYAYGAGRRICPGIQLAERGLFIGIAKMLWAFEISEPVDPQTGRPIPVDVDPVTGYLEGFLNCPKDFQATVRVRSQRRRKTIFREFDAAEQEVFRHYECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUV3</accession>
    <name>A0A317VUV3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bola domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_537855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464585.1">
        <property type="nucleotide sequence ID" value="XM_025612366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUV3"/>
    <dbReference type="STRING" id="1450535.A0A317VUV3"/>
    <dbReference type="GeneID" id="37114509"/>
    <dbReference type="OrthoDB" id="411584at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044572">
        <property type="term" value="P:[4Fe-4S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.90">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46230:SF7">
        <property type="entry name" value="BOLA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="109" mass="12346" checksum="3844AE370B097DB0" modified="2018-10-10" version="1">MASTSTTPIEDLIREKMTTAFSPSTLIIRNDSHLHAHHAAMRGATSKETHFHVTITSPSFQSKPQPARHRMVYALLKEEMSQEGGIHALQLRTKTPEEEEREKERQAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VV98</accession>
    <name>A0A317VV98_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_498721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464468.1">
        <property type="nucleotide sequence ID" value="XM_025609355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VV98"/>
    <dbReference type="STRING" id="1450535.A0A317VV98"/>
    <dbReference type="GeneID" id="37111498"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY77281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="360" mass="41332" checksum="A72EE8895C997EAA" modified="2018-10-10" version="1">MRKLIVQFKSTRRMTMSDAYWATNKVAAMKLARDIIYNTPFEGAVPEVYSWYEGTDRPGDKAWVIQSAPPSDSVPLKSRFNREHEQKDILDHIAKLQRYFQAYKMPRSYGSCSFTSTGQVCAGPLQQPNLGGPFTTSRDMMKAELRRDFSRAKRHHELQGWTCEPELRQQLAEFIAHSMNTMLSTIQDCDPIFTLNKLELSNFLCDKYGGRINYIIDFSWASITHPIMEFFNSYVTMFGVLPFFPNENWAILHRAVLNGFEKKHVDVDLRGLDFLAYIQEIRDPAESYRIGRELYEAFEKAKVKTPREIKGAEAMSAFMGLCAAVGARSWSPPGASPEDVYQAKVKNLTDSLREVRKWAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVR2</accession>
    <name>A0A317VVR2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_499303</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY75990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463987.1">
        <property type="nucleotide sequence ID" value="XM_025609368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVR2"/>
    <dbReference type="STRING" id="1450535.A0A317VVR2"/>
    <dbReference type="GeneID" id="37111511"/>
    <dbReference type="OrthoDB" id="3031538at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY75990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="404" mass="45567" checksum="DA215199172F1443" modified="2018-10-10" version="1">MDHHDRPRRPAHRRSRRGCGNCKLRSVKCDETKPVCRRCLAYGVSCTYASTGPLQASVERVVTMAQPFGLSYWVDTNDFLLSRFQVRTALTVSHGRSRQVLQNEVMQLARSTPYLRHAILTLVLMHDRHALDGSRPSMNLAESDHWDRALTGFNRKMSLGFPPKETGAVLTTAAILWFLVFCHVEARTPEDAWPLRCTAAVGPAWLQINGGKEEIWRVMPSSSSDPVADALAPYQLSKLFPGEPEALDLSKVPMAFTRLFGLSTASPGVDCSPYREVAVDVAQALYMDRPVFTNILSFVNCLRTMTPRFKRLLLERDPRALLLLGCWYWKARQLGVWWMNRRAWLEGDAICLYLERHFSDIDDIHTILSFLRQGFDRGQSGLSVEGVGSPPAHQPVGRLVDAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW02</accession>
    <name>A0A317VW02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_472955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464349.1">
        <property type="nucleotide sequence ID" value="XM_025608456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW02"/>
    <dbReference type="STRING" id="1450535.A0A317VW02"/>
    <dbReference type="GeneID" id="37110599"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="45"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY77162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="595" mass="67764" checksum="B691C01804F3F917" modified="2018-10-10" version="1">MEETQPRTRRRHPVDKYGPKFFDKSEHMQDRTAAMKAALNGDEPSRSEPAGGFDSTPYPYAPPGYTLKFTFHRGVNLPCADFGTFSSDPYIIAQLIVGLPQRHKQDPLLSFRTPTVRKNRDPIWDSEWVVANVPASGFQLKCHVYDEDAADHDDKLGNVYVEVDSVGEQWPGIKEQSFRVKKRMGSKRVYLFGNIAALASRRLDVGSHIVISVQCLGRTQSDEGAHVYTVGPNYWFKHFSPLIGRIAGTKDEIQSQNGKKKIITRYNFQAIQIQLKGPVPAELYHRYVEFKPFVAGMFTSHSLRGRILNRALHHQHERIYNFDKTTLNGQFPSPCIALTQKFLEFVHYAQGGRIFTYVITLDGQFRFTETGKEFGIDLLSKHTMHSDVSIYIAYSGEFFLRRLKHRHHRHSETTRNSGTSYSGDEQLEEPEISTDPTDYELFIDNDSGTYRPNAQYLPLLKRFISSNLPGLNVTTLDCRGDVVQMEALKNEQREFKKNEGNHMIFLQRSNSSSLSLSSSDEDELNERSGSQPKPRDSFTQKVHDMRDVKGQMMRWAQADNNDSPKNQESSSERQMTAAAKKAGSCKPAEENSVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZK7</accession>
    <name>A0A317VZK7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16">1.3.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_472174</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16"/>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464761.1">
        <property type="nucleotide sequence ID" value="XM_025608417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZK7"/>
    <dbReference type="STRING" id="1450535.A0A317VZK7"/>
    <dbReference type="GeneID" id="37110560"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="400"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Dienelactone hydrolase" evidence="20">
        <location>
            <begin position="592"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY78452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="829" mass="94345" checksum="9DF0005D9DE6B616" modified="2018-10-10" version="1">MTVTRSQTGKTPKKMERPGFIETPGRRVTRSSSRALSEEPSNSTADTQAQSNSTSRRRPSVKVKTEPLDEEPKPFATNGHADDSAGKPRIVDGWEEGKDPRIDYSGHFEFGGSLGVASMMIGFPLLMYYMWIGATYYDGKFPRPAEGQSMSEFFAHLGHLAYEGAFPSLKAWTIYWVFFIFEGICYLCLPGITVMGRPLPHLGGKQLPYYCSGVWSFYTTIVLAFLLHVTGVFKLYTIIDEFGPLMSVAILSGFLVAFAAYFSALARGAQHRMTGHHVYDFFMGAELNPRMFGILDFKMFFEVRLPWYILLFVTLGAAARQYEVYGYVSGEVGFLLLAHFLYANACSKGEECIVSTWDMYYEKWGFMLIFWNLAGVPLSYCHCTIYLANHDPATYHWNRYFLSFLYVAYLFVYWVWDTTNSQKNRYRQQERGTMVFRSTFPQLPWQTLKNPKTITADDGSKILVDGWYGKARKIHYTCDLYFALNWGLITGFSSPFPWFYPLFFACMITHRAMRDIERCRNKYGEAWREYERQVPYLFIPESYHDVPTQADGSGTMRMYFLSTLYLRFLCPSRADVSPGIYVFHPTIPGYPKARFPGVVVFSEIYQVTGPVERFARQIAGQGYICAAPSSYHEFTGPEALKYNAEDTDKGNEWKISKKIAAYDEDASLCVDYLLSLPTCNGRVGATGMCLGGHLAYRCALDSRVKAAMCYFATDIHSKTLGLGKNDDSLARAADIKGELLMIFGKNDTHVPPEGRDLIRKTLHDKGVLFSFYEVAWAQHAFIRDELSKGRYDPAITKACFEMLLELFGRTLKLDLGEHDGKELKIEDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1R3</accession>
    <name>A0A317W1R3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Membrane bound C2 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_472525</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464622.1">
        <property type="nucleotide sequence ID" value="XM_025608438.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317W1R3"/>
    <dbReference type="GeneID" id="37110581"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="236"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="437"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="584"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="720"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1094"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="49"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="869"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1471"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="871"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="890"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="908"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1471"/>
            <end position="1490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY78110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1517" mass="167123" checksum="68634ED30CB754EC" modified="2018-10-10" version="1">MASQDVEAKKGELRQQGAIEVAQQAAQDPQSNLNPEAVEKTLVEETRKAGVPAYQFDPNASPEEKAAAAKSRLPPGLNDSKPKGVAVVTDKDDGTPDQYDLPPPRSATDVLQEKTEGVPQVEEDLRWARDRTGWAPQFEHQPTQEEKDEGTLLDHQTFLEGRLDDKFYGDWYHNAGVIVFACLASWVIAILGGGLAWVFVVMAACSTYYRTSIRRVRRNFRDDVNREMAKQRLETDTESLEWINSFLVKFWPIYAPVLCDTIINSVDQVLSTSTPAMIDSLRLKTFVLGSKPPRLEHVKTYPKTEVDTVIMDWKFSFTPNDTMDLTARQLKNKINPKVVLEVRLGKGLVSKGLDVIVEDMACSGLMRVKVKLQIAFPHIERVDVCFMERPKLDYVCKPLGGDTLGFDINFIPGLQTFIEEQIHNNLSPMMYDPNVFPIEIAKMLAGNAMDQAIGVVAVTLHGARQLKNPDPFAGTPDPYAVVSLNNRVELGRTKTIHDTDSPRWNETIYVIITSFAESLTIIPYDWNEFRKDKELGAATFPLDRLEQEPEHDGIFLEVMASGRSRGAIHADIRFFPVLEGTQLENGQTQPPPEMNTGIARLVVEQAKDLDGSKSMVGQLNPYGVLLLNGKEIHITKKLKRTNNPIFQNASKEFLVTDRKSARLGLVIKDDRDLGRDLILGTYQMKLNDMLKMMEKGQQWFQLNGAKTGRAKLILEWKPVAVGGIAGGSGYVDPIGVMRFHFKSGTDLRNLETIGSSDPYARVLLSGYQKARTVTFRNNLNPEWDEVVYVPVHSPQEKITLEVMDEESINSDRTMGSTDLRVSDYVRENEHGEYVVDDERQLVSSGLRIGKSQKGTLNYTVAFYPTVPVVNPEDEEEEAEENLNDDAEGAELTRKSTDSKHKSVAGHSKTASIDSKATTALNGTSTNGTTPEAQSSRPSLDTNGTRPQTAKDSETMSVKSVKEAPKTYISAEDLTKYESGFLVFNVHEVQLSRPNVQVEVLMDDYMFPAYSSPKIRTKSAKIDDVGDAFVRELEFSKITLRIIDKNNTKDESDDHTVAKLTGDTLTTLQRILYTPTELILRSPQGEVSKVTVSARYIPVTMKLDPSESINNMGTLVVHFLDAADLPSADRNGFSDPYCKFRLNDKEIFKSKVQKKTLHPAWNEMVETDIKSRIASTCRVDVYDWDFGDKADYLGGTHVDIQSLEPFANTEISLPLDGKSGAIRLRLLFKPSYVVRSRQGSSTFAGTFATPGKIVGAPVKGVGFVGGNVIKGASFLKHEGSSFLKNGLMSRFRGDDGSSVHEAQEEEDVPAPLAPAAILVEGETPPAASPNNLQHARSRSVASHYGDRLGVAGKGETGTATITVVSASGFPPTANVRVFIKAQGPKGSKDVLKTKAIKSGGGPVYFDPSHETCRVHNTTADASYQVRVVDHSTFGSDSQLGEAPLFVDDQGSTAGQDKQVKVGTGTVTLRSSFAVSDSNLRPGTAHSNTNDGASDVMDSPDSKKTGRRSFLSKRSVSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2I7</accession>
    <name>A0A317W2I7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_497350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465029.1">
        <property type="nucleotide sequence ID" value="XM_025609313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2I7"/>
    <dbReference type="STRING" id="1450535.A0A317W2I7"/>
    <dbReference type="GeneID" id="37111456"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000982">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="457"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY79457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="573" mass="62221" checksum="9E4709585FB176B7" modified="2018-10-10" version="1">MLSECFIASTLASSKAPASASLRDVGVCVHEFQPTLNLRSTFKKSSTAANCLAVSPSHVFAAQSEKAIVHVYSREKGNQEATVPFPERIRSIAVAGGKNGDVLVLGTEGGRLILWETCTGRQVATTASHLRPVTALVVDPNSNFILSGSSDASVHVWSLVDLLSFTKPPSGRDRQPPNSPIRTFSNHRAAITSIAVGHSAARYNIAVSAAQDNTAIAWDYHTGRLLRTFLLPSNAISLALDPADRAFYVGYEDGSIQSIDFYKNQSIQHPLHDPSLQSTPSQPPAEDRWAPPSTDCGAAHALTLSYDGMTLLSGHQNGKVLSWAVGRKKYSSTAADYTHPVTNLFMLPPNGIPHPSLDLKRVAHTIIKPRYDHTLSETSQAAGTVPADYTFSTHFLPSISSKSDSPKPDEFAAAFSHAYFPESMLEEGLAELAAFGQSGSNGAPVSSIAQGISDDELAAKDSQISQLEEQLAVLKKKSTINETARQSTTEEVTQLRSDLANLHDYINELHEKQAQAQREKVLRQARKEERETRRREAWFAAEKKGKKGDAVLRKMDAEDTVMTSDTDDQSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2T4</accession>
    <name>A0A317W2T4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_471978</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464809.1">
        <property type="nucleotide sequence ID" value="XM_025608408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2T4"/>
    <dbReference type="STRING" id="1450535.A0A317W2T4"/>
    <dbReference type="GeneID" id="37110551"/>
    <dbReference type="OrthoDB" id="5431381at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000103">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF86">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="683"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1084" mass="121467" checksum="D782EFCDBBFBCABC" modified="2018-10-10" version="1">MSLSFTTRGSTRSFLRQHSQPNLSTRSFSTRSFSTRSFSTRHPLRTPTSTSASTIATSFLSRFQSLGPQTRTQTLDANQLQLLSLTLNRPSLFPNSPSLSNTPTSLPLGTPLPAGYHLVYFTPAFLENELGADGTDTSYNPASPFTRRMWAGGEVHWPRGKDGKPNPLRVGQEVQEMTTVLSAEPKIVRKTGEEMIVVGVEKEFRNEHGVAVLDRRNWVFRKALTTPAPSTSSSASPPATEAFNGPASSSTVTSGSTHTRTLRQTAVTLFRFSALTFNPHKIHYSTPWARDVEGHKDIVVHGPLNLISILDLWRDTRKTDGKGEGLVFPEKISYRATSPLYAEDEYKIVLDEGAGDGVGRVQIVAPGEVVAMKAEIQLKCDRIHPCTNCKKRNEGSTCTFIGRGPRGKVSNGRTSPTHVQDRLQHLENLILSFTQQQQHQQQQQRVGGEQVVGAGASAPQQQRTPSSTEEEGSSPSASDPAGRLVVGEEGTRYIDGAHWSAILEEISGVREYLRDNEDMGPSDEEQGDEETVGSSPAPTLLLGLQRQVSRDELLDGLPPRPVADRLVALFVNSKEPTTAVVHMPTFQKEQYTRFWSRPRDVSIAYMAFLYACLTMAVSIHQRTGEPLPVDLGDPMEVANNFRLLTAQSLVRSNYTVPGRYKVEALFIYTMAEFYRSEDAQVGVSFLLGNTIRLAMRTGYHRDPRQFPDVSPYEGEMRRRVWAIIRQLDILISFQVGLPRSVQDWQQDVELPRNISDQDFDESTTELPPSRPETELTPMAYIRGKSRLMAVFGKISDLAYSREPVTYDETLALDQQLNEAHELIPPVFKMRPLDQCVVDPPYQILRRYTLELLYLKSRCVLHRRYLTEVHTNPRYAFSRWVCMSASHEILQHQARVYQETQPGGLLYRDRQFPNSLQNADYLLAAMILCLELLQNPTGVQTEGADKDVAHCREDLLSTIETSHRIFDQLRQKSADAQKAYAALTIMLRRVKGATGSEKLAGESEEMLRYTLLTGPAQPPPYGNWSESPYPLGEIPMGITPEYHSLDVIGEMLDAPTNLDWHLWDQQIRDANMGLWDDTNVEDMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W504</accession>
    <name>A0A317W504_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_625789</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465712.1">
        <property type="nucleotide sequence ID" value="XM_025617307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W504"/>
    <dbReference type="STRING" id="1450535.A0A317W504"/>
    <dbReference type="GeneID" id="37119450"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000043">
        <property type="entry name" value="Acid phosphatase PHOa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016414697" description="Acid phosphatase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00072210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY81644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="473" mass="51947" checksum="8EA866009D2EB2D2" modified="2018-10-10" version="1">MASVATLFALAGLAGLAAGATITTTEPPLAAIQRAQATTLPQTWSSNVTGKAFDRFYQVWLENVDYVNAANDSNQQWLASKGITLVNYYGVGHTSQPNYCASVSGDNYGMDNDNFHDIPSNVSTVADLLNTKGISWAHYQEHLPYPGFQGFNYSNQETYANDYMRKHDPLVMFDQISSNDTALRLIKNFTSFYDDIENRELPQWAFITPNMTNDAHDTNITFGSKWLRSFVEPLMNDSYLWDNTLLLLTFDETETYGVPESEIYNDRNRVFSILLGGAVPEHLIGTKDETVYTHYSTLATVEANWGLPSLGRWDCGANLFSFVADKVGYTNWEVDPTHLYINQSLPGPLEQWGYSKYRANWPIPTTNDTCSAGNGILQSVIDAYKGQNPTYNYTAPFPYDAPYGLDVNIPYTRNGTTYVSGVNTTGTVGYDTNTTTTSSSSSSSSVAVSAGAASAMPVAGSMVAAFAALVAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9J5</accession>
    <name>A0A317W9J5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_520068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466069.1">
        <property type="nucleotide sequence ID" value="XM_025610091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9J5"/>
    <dbReference type="STRING" id="1450535.A0A317W9J5"/>
    <dbReference type="GeneID" id="37112234"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY83284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="269" mass="29749" checksum="6A103518D6219B3F" modified="2018-10-10" version="1">MSSGIPIHRLPTVTSGRHPAAAPSARKPSVAYPLPLQHTSRAPSGPPRQPSTGHVSSQLAPPWPFNPQETALIRAGYRPAFTPEPVAADQENASSQKPKRMAEPRARAARHKGQMNFASELRLLLLAYGDPSPHPSFSPEPLPETVRVLDEIVTDFVLEMCHGAAQYASYSRRQKIKVDDFRFALRRDPNKLGRVQELLRMERELKEARKAFDQNDDQVGNLKDAGKKGLEELGESVDGKKSKGKGKKNARRDSDVTEDAMPKKRKVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBR6</accession>
    <name>A0A317WBR6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_547313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466117.1">
        <property type="nucleotide sequence ID" value="XM_025613326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBR6"/>
    <dbReference type="GeneID" id="37115469"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY83649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="563" mass="64761" checksum="0FF6FBE02062CC8F" modified="2018-10-10" version="1">MDPDVSALTHKYLRIMPPTIYNTHQSFDFQNQCLRYPVPLHPDYNPEDLFAYSSQRWLWNEAQQLRNRYVAFDLHALIQVAEEAVGNTTPCINISKLPEGNFNKAFLVTLQDGREVIVKIPNPNAGPSHYTTASEVATMQYARENLQLPVPKVLPYCSRAEQSKLGTDKLEPSRRHSRARFPSYGSLYLRQDVSESESIKIDDTFAIGPTTGRTWFDDRRSEVQVHRGPCKLINHSTGYTSNLTTASNPGPSLQNTMTALVQREIACVNKLSSSHPDTQQGIFNGPDGYHPTKAAKRSVLQEYLKIQQYIVPNDNALNAGILWHNDLHTDNIFIDKANPTQITSIIDWQAIPIIPMFLIAHHPSLIEYDGPKPERFIQPRLPDNIDNLSPQERKAAKELHLSQTFWLYYETQVFKESRDLIHAFKYEDTLQSELMSLIGSIFDDGETHVQKLLSEVSTEDIWKQIVGKDEHGSPRVSCPLKYMKSELEMQRETYAKWMRDVERKARVLEEIGVYTGWNGAVSPGEYEEAVRRLCLAKERFLDREARTPEERVEWERVWPFEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDQ9</accession>
    <name>A0A317WDQ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HMG box protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_536669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465983.1">
        <property type="nucleotide sequence ID" value="XM_025612069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDQ9"/>
    <dbReference type="STRING" id="1450535.A0A317WDQ9"/>
    <dbReference type="GeneID" id="37114212"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="152"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="255"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="152"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="255"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="119"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY83198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="37682" checksum="C9B00A9C0A114495" modified="2018-10-10" version="1">MPLNLARCGGGVLQHLQLSSAFSRPIRQAISQSHVRCMSLATLGRFSTPNVRYAPVSVALSGRLTNGYATAATPKKRTTKKADPESPEAPKAKKVASKAKKAKTTKSKKATKKPRAKKVLTEEQKEAKKEAKIASDQRKLVKELKAAVLSPPKRLTNYFTLAMFAKLEEVKKEGKELAATDAFKEAAERAKAMSDAERKKFTDAAAANKEAHQEEYEKWLNSHTPLEIKQANMARRRLAQIQNKKFFPIHDPRLVKRAKVGYLFYAEERHQAGDLKHMTVPERGVRIAEEWRGMTDAEKQKYVRLQEADTERYFREYKEVYGEDAPNVGKNLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WGX5</accession>
    <name>A0A317WGX5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466743.1">
        <property type="nucleotide sequence ID" value="XM_025611885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WGX5"/>
    <dbReference type="GeneID" id="37114028"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY85726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="52" mass="6269" checksum="04688C9882C1DC8B" modified="2018-10-10" version="1">METKRKEVKEEEGEEEKNKRPVAMKRGPRRRREGKRKKDEVEDEVGLAFLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WH28</accession>
    <name>A0A317WH28_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_535917</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466791.1">
        <property type="nucleotide sequence ID" value="XM_025611897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WH28"/>
    <dbReference type="STRING" id="1450535.A0A317WH28"/>
    <dbReference type="GeneID" id="37114040"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.60:FF:000002">
        <property type="entry name" value="Protein-glutamate O-methyltransferase C1393.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="9">
        <location>
            <begin position="23"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY85774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="473" mass="53500" checksum="E9EBDF353B447E15" modified="2018-10-10" version="1">MEYDPSTPQYLTSDKSSFASVSARERWPVILTGAIDDLHRTVAAVTDEEKAQEGKAIIEKLAAFKYELQHNRQLTPLPEDGQPDIAEYNKELEQRGNPSWHHVPWLYSECYLYRRLSTLFSLSKHWKGYDVFARQKMSTFKSSRPAVLELAARYKELAEEAEKSTDGRDPEQVEQANRILFSEMCEICLWGNATDLSLLTSLTYEDIQKLQGSEARKASEKNILVNDLDAAFDVLQKARRERKNEERRVDIVLDNSGFELFVDLILAGYLLSAGLATTVVLHPKVIPWFVSDVTPPDFAALIDALSDAQGFYTAPDESGKKFDPLSEKEVSEVKFLFDHWSHLHQEGKLIIRPHTFWTTPGGYWRMPHTAPELFNDLKESELVLFKGDLNYRKLTNDAIWDPTTPFTTAIGPLGPKSGVRVMAFRTCKADVVVGLPAGVDEQLRQLPDGGGHESRKWAWSGKWAVVSFCDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHL8</accession>
    <name>A0A317WHL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_467427</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466890.1">
        <property type="nucleotide sequence ID" value="XM_025608204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHL8"/>
    <dbReference type="STRING" id="1450535.A0A317WHL8"/>
    <dbReference type="GeneID" id="37110347"/>
    <dbReference type="OrthoDB" id="10016252at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008688">
        <property type="term" value="F:3-(3-hydroxyphenyl)propionate hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019622">
        <property type="term" value="P:3-(3-hydroxy)phenylpropionate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050631">
        <property type="entry name" value="PheA/TfdB_FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476">
        <property type="entry name" value="3-(3-HYDROXY-PHENYL)PROPIONATE/3-HYDROXYCINNAMIC ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43476:SF3">
        <property type="entry name" value="FAD-BINDING MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="10"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="323"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY85873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="634" mass="72624" checksum="1E7AE6B1DB7D6A7C" modified="2018-10-10" version="1">MSADELWETIDVVICGCGPTGALLSAYLGRMGVHNIVLEREPVITTDPRGIALDDDGIRFLQGLGLYDFVYTKIGASMGRFKFVGGTTCDLHTKPIVEMDYNTTTGATGHVGMIGHKQPVLESQIRNAMSSTFCSLRCESTVVQIDEDEQWTYCTYRDSDGEHRVRARFFVGADGKTGYTRKQYLEARGVKLEKFHEQASQFLRAFYEETWVALNWRITIPTPRSHPSLPLWKAGYSPDQVYDLFFPPEFRFLCNPGRPAVCGRFGLPTDRLWRFEYLIRKDEDGYAMAAPEAMRSIVYPYLTHKGSQYKLAQDVQFPEDCIEVLRCRPFTFSSRTCNMWAKDRVILCGDAAHVFPPFGGQGIASGFRDAISLSWRLAMLCRYQPTGTNHHQVLKAWYEERKQQLALSLATTVANGRLVCETDPLKIFLRDWYIWFIQLIPSWRRQVQRGHRKDALLRYKHSDGMPFIPDLNGGLYLPQVYCRTTIGEILFTDDVIYSPNNTSLFRLFVYLQDNSDLPSIKDTLQNIQSWSRGEFNATTIPIIVESTSIDPSNEHNIFQIATAEEFSNSPLCNNRPKPLDYDPLLLRNKLQGKYVIVRMDRFIFASCTDVKELQKAIQSMLDHLYGEKRESCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJG2</accession>
    <name>A0A317WJG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldo-keto reductase ausK</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_517830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467185.1">
        <property type="nucleotide sequence ID" value="XM_025610010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJG2"/>
    <dbReference type="STRING" id="1450535.A0A317WJG2"/>
    <dbReference type="GeneID" id="37112153"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000024">
        <property type="entry name" value="Aryl-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF2">
        <property type="entry name" value="ARYL-ALCOHOL DEHYDROGENASE AAD10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="26"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00073126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY86594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="379" mass="42210" checksum="1E0BC176423C4CB3" modified="2018-10-10" version="1">MTEPTPPTELGRLRILSSTAGIRVSPLQLGAMSIGDAWAGLMGSMNKPSAFKLLDTFYESGGNIIDAASNYQNEQSEKWIGEWIQARQNRDSLVLATKFSMDYRSHEVGRGPQAANFAGNSRRSIHVGIRDSLRKLQTDYVDIYYIHYWDYTTSIKEIMDALHILVEQGKVLYLGASDTPAWVVAAANTYAIAHGKTPFSIYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGKFQTKAELERRESTGETLRNFGGRPPYQLEDEVKMSEALAKVASEHNIESVTAIALAYVMSKAGNVFPVVGGRRIEHLRDNIQALSIKLTDEQIGYLESVKPFNIGFPHNFVPPDPNVSGQSFLIARTNAIKFPNARKLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WK75</accession>
    <name>A0A317WK75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_90621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466699.1">
        <property type="nucleotide sequence ID" value="XM_025617737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WK75"/>
    <dbReference type="STRING" id="1450535.A0A317WK75"/>
    <dbReference type="GeneID" id="37119880"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35361">
        <property type="entry name" value="OS08G0443700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35361:SF1">
        <property type="entry name" value="OS08G0443700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY85682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="50681" checksum="39B6F98B404E03D9" modified="2018-10-10" version="1">MSTPSPTPPTPKGPRNNRRNPKKNMTPAAQKVAILATPPSSPPRNLSPGGTATDSSINVNASKKKHGRSGKKTREAPKASPASKGHRHTSSQPNNIIATPQVKDSPHYAGPTFHASPAPSALPIPSFFSKSLPESDLAPALESDGDNLDIGPDLDNTPSKPKPRPQVQEEERQSTPLDFLFKAAVEARNSQQQQSPEASIRIRSPQTDSKTLQHRKPNGTASGLFRLEMESPEFQNSQIGPSFATSYKDRMNALRSASSSSSSVCELDEQQKREKTEALKSLLLNPRPQRPSSASLVVPGQGDGAMGRPTPDPNVPHFATPVRTTSGPPAPLSHGMSYDQKQTFVGNGRHFSSSYTHSNAHQQFYSQNSPLRKEVFTSKAENFPAVYGETFYPPTAYEQPKSPPKYAQYPMYYPPPHHQSPVSRSVSMSTNAPAYDTKKMEDDLRRILKLDVSPAMPSSGMQSSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLG8</accession>
    <name>A0A317WLG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_566041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467387.1">
        <property type="nucleotide sequence ID" value="XM_025614536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLG8"/>
    <dbReference type="STRING" id="1450535.A0A317WLG8"/>
    <dbReference type="GeneID" id="37116679"/>
    <dbReference type="OrthoDB" id="2125469at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10951">
        <property type="entry name" value="CE4_ClCDA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471">
        <property type="entry name" value="CHITIN DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46471:SF2">
        <property type="entry name" value="CHITIN DEACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016351484" evidence="7">
        <location>
            <begin position="23"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="8">
        <location>
            <begin position="47"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY87179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="241" mass="26797" checksum="C784C66EEF1AB126" modified="2018-10-10" version="1">MLLITLNFLLLTIITLLQPSHSHPHNQTDPYPPTPYATVITHCAVPGTIALTFDDGPYTYTPALLDLLSEYGARSTFFLNGYRLTEYTDVLQRIFNEGHQIASHTYGHTHLPSLDYASIVNEMGALESLFRNIIGVVPTYMRPPFLAVDGRVLAVMAELGYNVVGASVDTKDFENNDPWLIYESVRRFLAGVDAGGSIVLAHDTHAQTVFTLTRAMLEEVARRGLYVTTVADCLGDTVWYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNU1</accession>
    <name>A0A317WNU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Enoyl-CoA hydratase/isomerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_517833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467189.1">
        <property type="nucleotide sequence ID" value="XM_025610011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNU1"/>
    <dbReference type="STRING" id="1450535.A0A317WNU1"/>
    <dbReference type="GeneID" id="37112154"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY86598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="282" mass="30733" checksum="3F1960990ADA282B" modified="2018-10-10" version="1">MSNYTYQHFNVTFPPEQQYVAHVEIHRPDKLNAFIEAMWLELSAIFTRLSSDPSVRSIVLTGAGDRAFSAGLDVKAASEGLLSDSPESDLDSARRAAHLRRHIVSFQDCISSIEKCEKPVIVALHGIALGLAIDISVAADVRLCSSDVRFAVKEVDIGLAADIGTLSRLPKVVGNFGWVKEVALTARTFGAEEALRVGFVNRVFGHKEEAVQGALELAGLIATKSPVAVQGTKELLNYSRDHTVQEGLRYTTVWNSAMVQTKDVSAALLSGIQKRKPTFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNX6</accession>
    <name>A0A317WNX6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_546230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467876.1">
        <property type="nucleotide sequence ID" value="XM_025613283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNX6"/>
    <dbReference type="STRING" id="1450535.A0A317WNX6"/>
    <dbReference type="GeneID" id="37115426"/>
    <dbReference type="OrthoDB" id="2142598at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="715" mass="81197" checksum="E36C33615D18D249" modified="2018-10-10" version="1">MLPTTDDIAKFISVAPDASEGKALIFLQAGDAALIRISTDCLFYEDPDRYSHPPANKSNQEPNATDTQALPPSYESHANPVNRLQRGPHTNAVIQAAQVRARDEQEMQNLLQNIQRVYQIFNSDIEPEHENGDYVTCNCEAHQYRRRKARRIGVQDMWSKAVMYPGEKAYHDSYQATMFSNNPYRWISSPYGLATYVMRKPDPARYTESVRQTISLNATLNMKAQTAVNAMEPRCNIWELDDSGVAGEAVTSSASRVDEKTPGSPEAPKRSKFSTFKKALSMGSSDRSASKANQMVSRARELRNAILEEESGRWPDPESRQIVAVYQEKVGMTQKIAELRAEYPLEYLHLLRAGYFESIPVDWATHISNPLKFRIDAPCGWRGITPTWRGYENTAEERLYWVLNHRTGSRGAWMKPDFISAMDMARERMATAVEPPPAYYSPDDTFRLQELSDGYSRQVMPAPFRPFDLPESATDNTMILLDVSGSMDFDPMRPVYKQYLVTGFTGSTQPKNKDVAKAIIRRFTDAMSNHDHNAYGYQLVTFANKASNIGLINHANLDDMWNNVKFGGGTRVMTGWQKIKDLHFQRYSESATYHPVYGWQAGPRTPMLRLLLLLDGEATDMDEFELDLLGLSWVHVTIFLIGVDGCPHHHRHANELQRISQANPHVSFVEAQGNAPERYVTHELLKRHLGYDVSISEFERLEQFPESAEPPVYTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQ25</accession>
    <name>A0A317WQ25_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_65091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467226.1">
        <property type="nucleotide sequence ID" value="XM_025617575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQ25"/>
    <dbReference type="GeneID" id="37119718"/>
    <dbReference type="OrthoDB" id="1044435at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="145" mass="16416" checksum="8044770AA44D1F12" modified="2018-10-10" version="1">MTPATLQGHKLYEIGPGSTPVMLPSSNPLDRVEGMLIFGLDADQRNAIYEKEGGLMELVNVQVDITQIDGLLLEHVILSRRVVDAGAFVWVGCRDYLIPMDKSAWPVDGFLDSQFYENICLSRRTVMMEWELKEMFMADFLENSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQ42</accession>
    <name>A0A317WQ42_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_72778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467455.1">
        <property type="nucleotide sequence ID" value="XM_025617626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQ42"/>
    <dbReference type="GeneID" id="37119769"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="177" mass="19871" checksum="ABC36F18D26C408A" modified="2018-10-10" version="1">MAQGTPSSERFSLDVPHPMIDSRHTRYCPVTKRNAEPPVQLDGRSPADQPRPFSYFRRMVGRGRGTGRVNPHRQERKYGCKMASLHGQDTLLSCSRNLIQRYAQHKSGGDGRISDSQKQHEFPSRGWTGWLGHGGENPSDPPLPSQIRRNSNTGTKVAGLGGAEWERSRRPIQDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQJ0</accession>
    <name>A0A317WQJ0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_585078</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468061.1">
        <property type="nucleotide sequence ID" value="XM_025615672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQJ0"/>
    <dbReference type="STRING" id="1450535.A0A317WQJ0"/>
    <dbReference type="GeneID" id="37117815"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="141"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="426"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY88699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="496" mass="53639" checksum="2150ECCB31FD4951" modified="2018-10-10" version="1">MRGFEASGPGALFDAPSTLATSIQVNPTAALASPPTDPKLVASNIEHVLQAMSYDNGGLVSVSGNSSGSTGKGILIGVLSAFGSAAVAVLVLAIFFFFKYTQRGRIILDRIGRPGEFDDEQAFAREEAEALEVMDDLTRSEYLRAKAFIEANPPESMQTDISLSQFLAIQEKGVSAWEFQPELEIANCFVEGRTEIEFYDSECSVQTNLPVPKQNDVYYWEAKIYDKPDNTLISIGMTTKPYPLFKLPGFHKTSVAYQSTGHRRHNQPFTPMPYGPQLLQGDVIGVGYRPRSGTIFFTRNGKKLEDVVHGQKTQNFFPTVGANGPCAVHVNFGQMGFVFIEANVKKWGLAPMTGSLAPPPPYGSEQGSILLESGRESAAQISQRVYQDANNARTSSTVRVAPSASPGPVRSPTDISLAQLAHIPSNEDVGEGSSRANGEGEQVPLLHTDDLDQIPPPEYSSPNGSLRGSEDLHPIPSYDAAVGNRDGHDLPTDETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WT28</accession>
    <name>A0A317WT28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_64160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467861.1">
        <property type="nucleotide sequence ID" value="XM_025617565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WT28"/>
    <dbReference type="GeneID" id="37119708"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="126" mass="13894" checksum="6E52D692495926ED" modified="2018-10-10" version="1">MKRRGENDEVSTGPGPSSQATCQPAVRVRDLAVGCIAASSSIHPSMLAVSFCGLEIFPFVSFSFLIARSFLAFDRPWLAPWLTSFSSFVSTILLSTPLLFPFLLTPSVCRSVSLWLTPLSYTYPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUW4</accession>
    <name>A0A317WUW4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_535062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467833.1">
        <property type="nucleotide sequence ID" value="XM_025611689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUW4"/>
    <dbReference type="STRING" id="1450535.A0A317WUW4"/>
    <dbReference type="GeneID" id="37113832"/>
    <dbReference type="OrthoDB" id="5357513at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000045">
        <property type="entry name" value="Aldo-keto reductase (AKR), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="316" mass="35362" checksum="5AF5AD148B9BA995" modified="2018-10-10" version="1">MARAAMSKLSWESHVLRPVQNAPPAIIPTLIYGTAWKKDQSADLVHQALGAGFRAVDTAAQPKHYREDLVGGGIRRALQDGYVRREDLHVQTKFTSVNGQSPDDMPYDPKASVTEQVHASIRSSLHNLRPSDTPDSTNDAYIDMLILHSPLPTMSQTLEAWSTFETYVPHQIRNLGISNTSLSILEELFSHATVKPAVVQNRFYADTEYDVPLRAFCRENQIIYQSFWTLSANPELVRSNVVQLLAHEADISPAAALYCLVLGLGYTTVLDGTTKRPHMEADLAALQKIEQFTEDQPELWQRILGRFQQLTGDHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WV39</accession>
    <name>A0A317WV39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_594537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468592.1">
        <property type="nucleotide sequence ID" value="XM_025616204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WV39"/>
    <dbReference type="GeneID" id="37118347"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="425" mass="47319" checksum="50EE722AA2FFE8C5" modified="2018-10-10" version="1">MSRPVHCQNVTAAAPAEERVGWVSPPTTRGTSDILFSCLSVFIICSWKCVHLNIPSIEESEAGCHTAWGWLPFWPTAPLRRLWGRKLRWMALIAIAPEIGIAVAFKDFMKAREIFKEYQHLGFTMTHAFYACMGGYRIAIPQALRHRDGAAHNNELPTSGAAPVEALEGGPAPGHSLPLVKEEDIRNASASDAITKGLAILQCGWLVIQSIARAAAGLPLTELELMTLAFIPCALVMYGLWWDKPFGVQRATLIYPLDPKNARALHDRLGLSNRLARSARNEDGAQSFQVLLEFYFSVWSMRDHVYWDSVICNITSIVFSVFHLIAWNWEFPSKTVKILWRVFSVTATGAPVVLVTTPSLLSCTSLWSSGVWRALGTFIVVSFGLGWVYIIARVSLIVLVFYCFSSMPADVYKAVQWTAIFPHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW75</accession>
    <name>A0A317WW75_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_534351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468483.1">
        <property type="nucleotide sequence ID" value="XM_025611526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW75"/>
    <dbReference type="GeneID" id="37113669"/>
    <dbReference type="OrthoDB" id="4093673at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057394">
        <property type="entry name" value="PIGBOS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23670">
        <property type="entry name" value="PIGBOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="65" mass="6938" checksum="B6426B9E58462B22" modified="2018-10-10" version="1">MSRNWVPALMAIGMGVWTGYYSFQPALRDLQSEKGNGPQTQQSPDQKIAQPSAPSSNGDSSKPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWX9</accession>
    <name>A0A317WWX9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Composite domain of metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_43856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468608.1">
        <property type="nucleotide sequence ID" value="XM_025607498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWX9"/>
    <dbReference type="STRING" id="1450535.A0A317WWX9"/>
    <dbReference type="GeneID" id="37109641"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="80"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="437" mass="46966" checksum="9456FD1EF47899B2" modified="2018-10-10" version="1">MGSIASPNRPTPADITINNYKPGDPDRILFQNVRILDSTGCLPYLGDVLIQEERIVAVGQVDPAAATGTFIIDGGGKKTLMSGLVDAHTHLSFNNAKSTEGLVNMPLEEHVLATAQSAKTYLDCGYTMCFGAAAARPRLDIAVKASIKSGLIPGPRTLANTPEITTTGGAIIPEIARSADGPHEMRKTVREFIELGTDNIKLSLTGDNIVDNMPSDETYFTLEETVAAVEEAHNRGKRVCAHARSEASVKLCLMAGVDVIYHASFADEESMDMLEQKKDSVFVAPAINLPLATCAGEGVPYGFTVEMAEKKGVKEEVEAACKTMTEMHRRGIRVLPGGDYGFAWAPHGTYARDLQHFVEHFGYTPMESILAATALGGEIMGHPEELGKVQPGYYADVILVDGDPLEDIAIFQDTSRLHAIVINGHIHKLVDPSGTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWZ3</accession>
    <name>A0A317WWZ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_574177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468799.1">
        <property type="nucleotide sequence ID" value="XM_025615009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWZ3"/>
    <dbReference type="GeneID" id="37117152"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="28"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="282" mass="32686" checksum="55ED7072A97CBDEA" modified="2018-10-10" version="1">MSEAGDFTQPLVTFPNFVQSIYPHYFGPQVTIHIGENYSIPVHKEVLCSRSRYFENMFKKHFQEGQADEAHLVEIKDVLSIRGFEMFLQWLYTYQIIFMPQSPTEEISTAIEFARLLDFYNISHKATERFLAKHIKHTIMSNCAQDLTRSRMFAVETCYHQYFTSEQILSAVVLPIGHPVRAIIAQAMVPGYLRDHDFKFLDEAETVPGFALDVLRETRTALKADGMLTSNIEFRDPMTGELVRCSRWPVDSELHRLWGFPARPAWTFQPYTPSLVKAESEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2R6</accession>
    <name>A0A317X2R6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">sterol 14alpha-demethylase</fullName>
            <ecNumber evidence="12">1.14.14.154</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BO94DRAFT_555079</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>32-hydroxyeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxoeburicol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75431"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="23">
            <dbReference type="Rhea" id="RHEA:75432"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>32-hydroxylanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-oxolanosterol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75107"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:75108"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>32-oxoeburicol + reduced [NADPH--hemoprotein reductase] + O2 = 14-demethyleburicol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75435"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:194329"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:75436"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>32-oxolanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75111"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166681"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75112"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:68068"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:68069"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68064"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
            <dbReference type="ChEBI" id="CHEBI:176902"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:68065"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54028"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:138031"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:54029"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:68060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:138029"/>
            <dbReference type="ChEBI" id="CHEBI:176901"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:68061"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>eburicol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 14-demethyleburicol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:75439"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194330"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="24">
            <dbReference type="Rhea" id="RHEA:75440"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>eburicol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxyeburicol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75427"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:70315"/>
            <dbReference type="ChEBI" id="CHEBI:194328"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:75428"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>lanosterol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:25286"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:17813"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.154"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:25287"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>lanosterol + reduced [NADPH--hemoprotein reductase] + O2 = 32-hydroxylanosterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75103"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16521"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:166806"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:75104"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 26">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.154" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469640.1">
        <property type="nucleotide sequence ID" value="XM_025613769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2R6"/>
    <dbReference type="STRING" id="1450535.A0A317X2R6"/>
    <dbReference type="GeneID" id="37115912"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008398">
        <property type="term" value="F:sterol 14-demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 25 26" id="KW-0349">Heme</keyword>
    <keyword evidence="9 25 26" id="KW-0408">Iron</keyword>
    <keyword evidence="11 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 25 26" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 26" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 26" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="25">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00051540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00051806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00052067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00052625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="PWY91912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="510" mass="57605" checksum="46B2EDB2E3F9DDD3" modified="2018-10-10" version="1">MASIAVVSAYAFAAALIAIVLNVARQLLFRNEKEPPVVFHWVPFLGSTISYGIDPYAFFFSCRQKYGDIFTFVLLGKKTTVYLGVQGNEFILNAKLKDVNAEEVYSPLTTPVFGSDVVYDCPNSKLMEQKKFIKFGLTQAALGSHVQLIEKETLDYLKESPRFRGASGVIDVPAAMAEITIYTASLALQGEEVRRKLTAEFAELYHDLDKGFSPINFMLPWAPLPHNRKRDAAHARMREIYTDIIKERRRNPDEEKSDMIWNLMHCTYKTGQPVPDKEIAHMMITLLMAGQHSSSSISSWTMLRLASEPQMLEELYQEQLANLSHKNGNFEPLQYEDLDKLPLLQNVIKETLRLHSSIHSIMRKVKNPLPVPGTSFIIPESHVLLASPGVTALSDEYFPNASRWDPHRWENQQPDKEDDSEMVDYGYGSVSKGTASPYLPFGAGRHRCIGEKFAYVNLGVIIATIVRHMKLFNVNGRKGVPGTDYSTLFSGPMKPAVVGWERRFPESFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2Z2</accession>
    <name>A0A317X2Z2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_389295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469086.1">
        <property type="nucleotide sequence ID" value="XM_025607310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2Z2"/>
    <dbReference type="GeneID" id="37109453"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="149" mass="16635" checksum="425A0792ED14076B" modified="2018-10-10" version="1">MRRVVHRRREEEPEERRRLDGLANPGHVTSPASWHYCIVGLLLFSAPFSLVSLWYHPELVPATPCKDFKWLISRGAIALDKGCPEKSSTGSQNSDPFPRHIEANSHLGDDLDSVLDVQRPRASPSSYTRTGISPPLIGGEVQDRSTTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3F0</accession>
    <name>A0A317X3F0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469925.1">
        <property type="nucleotide sequence ID" value="XM_025611217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3F0"/>
    <dbReference type="STRING" id="1450535.A0A317X3F0"/>
    <dbReference type="GeneID" id="37113360"/>
    <dbReference type="OrthoDB" id="3903267at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="404" mass="44330" checksum="149CAD784C8A19C2" modified="2018-10-10" version="1">MGSSRKSSNRPKKRTLVRWDGTFPAPIQSLSLWHLYKPRLTDVENLNELLLLTVQSVCNTNSIKIPWADVARTMGHNVTEGAIVQHLAKLRSRRVAAEKAVPPPLRRGGIGALCKSTAESPTGSVQGERPKRKSAQTKLGSGESRSKAQHQDTSSDEDWVEGRASRIRRKFPNKKKSISQAAESTPEQLKYESDEDDIDSSVNSSNDLLAPGAKFLEYPNDTGQPETSPSASGSEPKRSKLVVLKYRRHASNDGDTVSHSVGLAVDPGNLHDAASFPQYYQQSSGDNAYSVDSNANFMDLLSQDSPMGFAPVGSSSMEVLSHEPGVAAHGDLWQSGLGQPFSSAMYPAYHNTVDVDTANDPLDFSQEMFNRLASFEPETYQHMSGNYMQMDEAIHPYQVSNDMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X424</accession>
    <name>A0A317X424_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_622451</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470077.1">
        <property type="nucleotide sequence ID" value="XM_025617082.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317X424"/>
    <dbReference type="GeneID" id="37119225"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904688">
        <property type="term" value="P:regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:002031">
        <property type="entry name" value="Translational activator, putative (AFU_orthologue AFUA_2G07960)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="8">
        <location>
            <begin position="1344"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="1521"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="6">
        <location>
            <begin position="1981"/>
            <end position="2018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2633"/>
            <end position="2652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2675" mass="291033" checksum="4B6FB295225F0573" modified="2018-10-10" version="1">MDDFPWDQVESGDLGSLQVVLFDSSTARRIRALQDLRDRIGSSLPSQTHQPLIGLLFKTCPRYVDRPSRQAVQQCLRSLLKAPVPTDDLKYLSQKLQAEAAKPALAPGPALVLLEWCSIVLQILAEDSETPLSAVLDTIAVDAKALDICLAANPKPAVKASALRVTRRALRATFSAAAWGEDAVRESVRRLTGDSTTGQKNAPFLGVISGVCARLPTKKSVLEGEKKLILSYYVKELAGSKSAPPAHIADALGDFFVSFISYEDLASELVPPFEKAMLRSPEVVFSGLLPSLCASLPDGIDISELLHSRLLKHLLSSMKSNNSAIRQGALRSFEALLLKSKDQNLLIKVTSEVVGPLKTQKITNPEQRAVYAQAVTAITPSVDVSKDVVQGFVPLFARESNEAALEQEIKSFCKHLAFLVQSQVKVSDDVANAIVKGSSDKRVPFKKLWQLNVSDVIWEVEPSTLASSNVEPLVNKFLNKMRELYNEVASNPLPSAQAGSLSTAHVYLALLKRSSTLQSFDKSAWEETVAQSMVLNPKPSFLLNPKAYSKLSSRAEIQWAVRALSAVTAGSKFEQADDAAKTAWAQAVIYNVVAPGLHTSFRDEAARALSEVHLKNVGSVSRMVISALWSWVHSFRTGEKESAPVSAGPESERFLHLVVKALCPPASSLRGVDNVATDLRNQLVELLVLCRPELIPNVSWISSCLRTGTDPGDLVREFPEKCVEQLTRLHEDPVQSKVPQIDAAIWSAAGELAFVAPDAMVPRLVSQIQDDLNTSRSSKFTATDVAIARTPEGTMFVDVLSTKSKQSNFDKNTKDYDILKWEEELRAQLGDKKGQKQKKLTAEEQSKVKAQLVKESKIREEVLQEIKRIERGCGIIQGLADGPAIDADGWINPAVSSLLSLTEAGAGLFAGDVVSKAYIKCAEKLSSRLGPLRPFVGIATLRAIGKSYLPQEMEVEPLGQLVTRILYRVRFASEQRPLDSTSLAYVLPLLFLVLSRNGIDEQRGEEEGEQVLLALEILSFHSGSFTDERLPRVEVLNNLLASMQKYTQHYKLIKDTLFDFSRCISANINKDELDILLKGTIVADVSVRTSVLQVIEAEIDLTDLDFSEHIWLERHDHVEENAEIAENIWEENALEVDDSSYGKIIPYLSSKDSQLRGAGARALAHAVATNPSVFNDIFAELQSKYTVEIQPKAPEKDSYGMPKKMDMADHWELRSGIALAFGAMTDLFEGEQTVSFLRFLIERGPLIDKSSTVRAQMAESGRSVIAVRGQQKVEELMVLLETTLETSDKGSETSDLLNEAVVVLYGSLAQHLKADDPRLQTVIKRLLDTLPTPSETVQSAVSGCLPPLIRLSRPQSGQYVQEMLDQLLQSKKYATQRGAAYGLGGIVSGRGIITLREFQVMSHLHDATENKKEPHQRQGALLAYELFATILGRTFEPYVIQIVPQLLAGFGDVNPDVRAACLDAAKACFSNLSSYGVKNILPTLLDGLDDTQWRSQKGACDLLGAMAYLDPQQLAASLPDIIPPLTVVLNDTHKEVRSAANRSLQRFGEVISNPEVKSLVSVLLKALSDPTKYTDEALDSLIKVSFVHYLDAPSLALVVRILERGLSDRSNTKRKSAQIIGSLAHLTERKDLISHLPIIVSGLQLAIVDPVPTTRATASKALGSLIEKLGEDALPDLIPNLMSTLKSDTGAGDRLGSAQALSEVLAGLGTTRLEETLPTILQNVSSSKPAVREGFMTLFIFLPACFGNSFAAYLSKIIPPILAGLADDVESIRETSLKAGRLLVKNFSSKAIDLLLPELERGLADDSYRIRLSSVELVGDLLFSLTGITAKADAEEEEEEAAQAGQSLLEVLGEERRNKVLSALFICRCDTSGLVKSAAMGVWKALVASPKTLKDMVPTLSQLIIRRLGSSNMEHKVIASNALGDLIKKAGESVLATLLPSLEEGLQTSPDVDVKQGICIALRELINSASAEALEDYEKILISTVRVALVDNDEDVREAAAEAFDALQQILGKKAVDQVLPHLLLLLRNNEDAEQALSALLTLLTEQTRANIILPNLIPTLLTSPISTFNARALASLAEVAGSAMTRRLPTILNSLMDEIVSTTDEVHREELSSAFDTILVSVDEFDGLNAMVNVMITMMKHDDHHRRTNAAIHLNKFFANAEIDYSRYHQDLIRVLLISFDDRDKNVVKAAWTALSGLTSHLRKEAMEVLTIPVRQVLRSVGVPGANLPGFSLPKGITAILPIFLQGLLNGSVEQRTQAALALGDIIDRTGADSLKLFVTQITGPLIRVVSERSVDIKCAIFFTLNKLLEKIPLAVKPFLPQLQRTFARGLADASSETLRNRAAKGLGILITLTPRVDPLIAELITGTKTTDIGVRNAMMKALQEVVGKAGANMSEASKNALLALIDDDASDQTDAVAITNAKLLGALVKVLPAATAGPLIKNRVLTATASHASILGLNALLVESPSSVTEHFSAETQAVICQGVTNKDPFIADNSVLAAGKYLLVEDEHRNFEVNKAIFEALAPCIQPGTPSDTRRLTLVVMRTVSRLHPELTRPHLALLAPPIFASVRDVVIPVKLAAEAAFLAIFSVEDTEGAVFEKYMAGPGATLPPGPKRSMSDYFKRVALRLAAQARERKEAEGGQGGLGLSNDEVEDEKELWSIGKVDLGDGAFADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X443</accession>
    <name>A0A317X443_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_615962</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = 2-dehydropantoate + (6S)-5,6,7,8-tetrahydrofolate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PanB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469876.1">
        <property type="nucleotide sequence ID" value="XM_025616784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X443"/>
    <dbReference type="STRING" id="1450535.A0A317X443"/>
    <dbReference type="GeneID" id="37118927"/>
    <dbReference type="OrthoDB" id="425211at2759"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881:SF0">
        <property type="entry name" value="3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="291" mass="31381" checksum="C7E2237374FC4361" modified="2018-10-10" version="1">MPLVLPRSLPSPPRYRPQTFIRWSSHSAPQQPTTHTNTRKKVTIHTPQNLYRRNEPITILTAHDFLSGLVADAAGIEVVLIGDSLSMVALGMKDTTMVTMDEMSLRYRSESRAVKRASLIADLLMGSYEVSPSEAVESTIQMVKQGRVNTIKLEGGAELAPTIKRIVDAGIPGKTAAGAVKVLRDAMAVQEAGAFMILVEAMPAEVAAIVSKRFRVPTIGIGSGNGCSGQVLVQRFVKRFADVWGEFKREVKGGVFPGAEFGYGIGEEERVRFEEVVGGGSSALEDGEPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4D0</accession>
    <name>A0A317X4D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Autophagy-related protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO94DRAFT_343305</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 25">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Forms a ternary complex with ATG13 and ATG17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470220.1">
        <property type="nucleotide sequence ID" value="XM_025607050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4D0"/>
    <dbReference type="STRING" id="1450535.A0A317X4D0"/>
    <dbReference type="GeneID" id="37109193"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000817">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000399">
        <property type="entry name" value="Serine/threonine-protein kinase atg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="23"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="333"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="524"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="791"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="873"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="929"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="354"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="537"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="800"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="935"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PWY93459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="954" mass="104401" checksum="82B7C8CC1BAF947E" modified="2018-10-10" version="1">MASAHHSRRSREDARPEMPIGHYTRLDEIGRGSFATVYQGVHTKTRTYVAIKSVNMSKLNKKLKDNLSSEIHILKGLYHPHIVALIDCHETTSHIHLVMEYCALGDLSLFIKRRDSLADHRYTRDMISKYPNPRGGALSEVVVRHFLKQLSSALKFLRDRNLIHRDIKPQNLLLCPSPSSYRSGMAQVVPFRGSEDSFSPTTGLESLPMLKIADFGFARSLPSTALAETLCGSPLYMAPEILRYEKYDAKVDLWSVGTVLYEMVVGKPPFRASNHVELLRKIEKGEDRIKFPEENPASDEIKALIRALLKRNPVERLSFSDFFENGIITGPIPGLLADDSPSRRRSSVDPMAAQPTSRPASRTGRSTPTATIRERDVPYVGGRGEPLPHPVAQRALTQSPRPETPPTPMRRTGSGDRPLSTSKVPTPPASYPTRPSPVSLATAPARQELVDRAPTTTTTTDRLRSRTASSGVPQTDKPVDKAKDARENAAQEVAFERDYVLVEKRAVEVNAFADEMAYNPRMQGAQAGAVSRRPGTPTANASSPQASPSKAMQIISGRSRADSAHVRQHSYERRYGQSPTSATSAISKALNMASGRLFGMSFSPPMTITKGGRSPPLAYNPFPAYPSAQASLIVLTDGSRPSATLDEDSKTVHELEECATRSDVVYGFAEVKYKQLIPLAPSVQTDPSGKPMPDVVDSTDGGLTVDAIVTLSEEALVLYVKALALLAKSMDIAGAWWTRRNRGEAFGESAVSRADVASNRINNVVQWVRNRFNEVLEKAEFVRLKLVEGQKRLPPDHPSHPSNLSIGSSVGSGASTDVVVSPGVTAEKLMYDRALEMSRAAAINELTGEDLAGCEIAYVTAIRMLEAVLEDEELPRPGQSSGADRGDSRRDNDKIMLDGVQAEDRQVMVKLVSSMRNRLAVLRQKLARLSKRYTPPSSGPGKMPPSNLGATPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6B7</accession>
    <name>A0A317X6B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GABA permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_531857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470626.1">
        <property type="nucleotide sequence ID" value="XM_025610991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6B7"/>
    <dbReference type="STRING" id="1450535.A0A317X6B7"/>
    <dbReference type="GeneID" id="37113134"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY93865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="537" mass="57954" checksum="4A3C4E7C7E88CB31" modified="2018-10-10" version="1">MVAKASPTALSANSGAEEAGLAGPGDSQLLAKLGYKQELRRQYSTVQIFAVAFSIMGLVPSIASTIAFSLPAGPAGMVWGWLTASILIFFVGLAMADMASAMPTAGGLYWWTHYFAGKKYKNALSFLVGYSNTMGLIGGMCSVDYTLSLMILACVSIARDGNWSASNGTIYGVYVGLILVHALCGIFSGPIMPRIQTFCIYINIAIIIATVIALPVGKVSRGDFLNPGSYVFGHVDNDTSWPTGWTFILAFLAPIWSIGFFDSCVHMSEEALHAAKAVPLGIIWSSGCACVLGFLVLSILAAVMNQDVDATINTVFGQPMAQIYYDALGKKGALGFMGVLIVIQFLIGLSLIVAASRQAWAFSRDGALPFSNYFRHVSRRIRYQPVRAIIGLVVVCIVFGLLCLINSVAANALFSLFVASNYVAWGTPILCRLIWGKERFRPGEFYTGWLSRPIAIVAVVWLVFGLILSMFPSTGPNPSPSEMNYTIVINGFVWIACMTYYFLFARKWYTGPKMTVDGVEGDSDTESGSKSDEATVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6F2</accession>
    <name>A0A317X6F2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic ring-opening dioxygenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_510312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470900.1">
        <property type="nucleotide sequence ID" value="XM_025609730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6F2"/>
    <dbReference type="STRING" id="1450535.A0A317X6F2"/>
    <dbReference type="GeneID" id="37111873"/>
    <dbReference type="OrthoDB" id="7396853at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF1">
        <property type="entry name" value="AROMATIC RING-OPENING DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G00640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006157">
        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="6"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY94139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="294" mass="32694" checksum="CEC9E6092066AD71" modified="2018-10-10" version="1">MGLTPVHFFSHGSTMMLGEESTSADYWRKCGDEALAHGIRGVVIMSPCTNIVSQGAHWDCYGDQIQVSTNPNPGKSPVAYVHPSKYVDYKLNADLQTARHCVDLLAKEGFNVSGNDTFDWIHDVYLILIRMFPNGCPPTSIISLNARYDPHYHMKVGAALRQLRADNFLLIGTGGAVHNLYRNRWAPMLRFRDNFAMDTPPEGWALGFRQAVEDVILKSSGPRLRRAMTRLMKHPEYRDAHATDDHFMAAMFVAGAAGDWEDDGSPAVLGAETWELTNMCNSQFTIGAWGSKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6N3</accession>
    <name>A0A317X6N3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_554746</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469968.1">
        <property type="nucleotide sequence ID" value="XM_025613737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6N3"/>
    <dbReference type="STRING" id="1450535.A0A317X6N3"/>
    <dbReference type="GeneID" id="37115880"/>
    <dbReference type="OrthoDB" id="5350192at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="40"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="318" mass="35953" checksum="E7DF66B2A3086C56" modified="2018-10-10" version="1">MGVMRLPRPAGVYVPNSPTRGLTSEMISSPLSPEFNFDSETLTPSIIPALEYVSSKLEQRMMHVTLLVGRGKPYPTGQPSDLIVIPITPLDETAWRIVYRTVAKGASKFSLGPSWTDALNRSQHERQAHDYLIQQSIMQNEVIFSREGLTLLNVDRIYTLKRRLCILSHRSTPPEDTYITSCAQLLQRTIKDFHGRPFSRGFFHRVYEQLDVPDELLTQVATSFRKQYKQEGIIMPPRPKAELARKSPLRAIRAARRQNPPPTRYNLPTKRGPKTPLSASDVTPITRNEWNMLVVTDFPCGKATVTKWTPSPTVMAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6U8</accession>
    <name>A0A317X6U8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_543517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit TRAPP (transport protein particle) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471054.1">
        <property type="nucleotide sequence ID" value="XM_025613142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6U8"/>
    <dbReference type="STRING" id="1450535.A0A317X6U8"/>
    <dbReference type="GeneID" id="37115285"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000007">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="246" mass="27423" checksum="E1ADE7304E14EAE8" modified="2018-10-10" version="1">MTQPARHAAMLSISNSGPNAPVAVDKQQSAQHLHTQSQSSQGLRVPSNRKTIYDRHLNRSRSAELSRASFAFLFAEMVTYAQRRVTGIQDLERRLNEQGYPLGLRLLDLLFYRTMSSSTSSSLSSSSTSASPPNRPLRILPLLHLIHGPLWRLLFNRPADALEHSVSPETPNEYMITDNDPLVNTYISVPKEMSMLNCAAFVAGIIEGRFFTVWSAIVLMQRFSFSILDANGFTLWASRGVMGQAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7B2</accession>
    <name>A0A317X7B2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_582487</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470842.1">
        <property type="nucleotide sequence ID" value="XM_025615480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7B2"/>
    <dbReference type="GeneID" id="37117623"/>
    <dbReference type="OrthoDB" id="10555062at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="139" mass="14399" checksum="81EC4F0CC5B9533E" modified="2018-10-10" version="1">MGASLSTEATVSPTEINLGPRRRDIRPGSSLGAQADDTEGRPSGHPAAVGVKPPNSGQKKKSRNGGRQGTQKCRLLGFPVLPYGPSLSPAPIGSACDPGPPRDHLITPSGKSYQTFASGNDTSRRLTLFLATVPVDALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7J6</accession>
    <name>A0A317X7J6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_448337</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470932.1">
        <property type="nucleotide sequence ID" value="XM_025607528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7J6"/>
    <dbReference type="STRING" id="1450535.A0A317X7J6"/>
    <dbReference type="GeneID" id="37109671"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="80" mass="8921" checksum="EC7BD3D7316449F8" modified="2018-10-10" version="1" fragment="single">MYLVSRAAYHGHENIIRILLDFGVTDLDSKDKYGRTPLSHAVLTRHDNVVKLLLSTGIPDPNCRDDDGQTPLAQAAYYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X866</accession>
    <name>A0A317X866_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_460734</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469859.1">
        <property type="nucleotide sequence ID" value="XM_025607894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X866"/>
    <dbReference type="STRING" id="1450535.A0A317X866"/>
    <dbReference type="GeneID" id="37110037"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY93098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="581" mass="64839" checksum="010AC39B90DB5999" modified="2018-10-10" version="1">MEPANGVLAQRRPRVERGRSRNGCQSCVAKRVKCDEKHPCCSRCTRLGSACEWVRPRPSLATRRRGFGPIKYRQANHWTPKPILPKFMENVRDGVTHTGEDEGSPGLSSLSSSCTTSPLRSGFKWDLSATGCLPPSALDRSIASPQNLASLDFIAPIWLTAVTPLFLVDATDEGPSLGSNDGQAVSFHQSVLAPLKSTRSPPLSAHALFLRHAWDKRIALHFLLAVSHSEIAIYQGQGARPTAESRFHLQKGVELLVQVWNPVTLSDHFEVMLSFLYIYMFWMRRDRLAPSRLSALSSTVLAYVRLYGLDGLCTDEEIVSAPQNVNAVPDKVLLSRVFIYLYDRDGFCSFFNCGGSFASYVHENPEASRKIWRLSRTAFLCFPRDSICFDLNATPEVEEAAVLQVYFELIRIHHRINSYSQKSSIENEAMPIQRQLDQLRKERSSLFQQVATLGDDGHSPSLIELVTVSLFYAVCIYLCRSRSPALGEQPVPPEVQTALTGLITTAHRTISRGSVQLLERFQWSLLILGLETNDPIHWDWVGKNITDAAIREVFNVCLRVKKQSGGSISIATLRQLVGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8B3</accession>
    <name>A0A317X8B3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_543185</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470663.1">
        <property type="nucleotide sequence ID" value="XM_025613126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8B3"/>
    <dbReference type="STRING" id="1450535.A0A317X8B3"/>
    <dbReference type="GeneID" id="37115269"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="115"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="14"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="292"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="576" mass="64158" checksum="B2207EEDFF28637E" modified="2018-10-10" version="1">MDGVEITKAVLNKGKQMASVAASAANGNGGKKRRKGTDLKPIVTNDAATPGVDPATTTTTEGGRVPAYGVPPSRSSSSSSGEELETTAEEEDSEDYCKGGYHPVSVGETYNNGRYVVVRKLGWGHFSTVWLSRDTTTGKHVALKVVRSAAHYTETAIDEIKLLNRIVQAKPSHPGRKHVVSLLDSFEHKGPNGVHVCMVFEVLGENLLGLIKRWNHRGIPMPLVRQITKQVLLGLDYLHRECGIIHTDLKPENVLIEIGDVEQIVKTYVKEEAKKEQKEDNRNGRRRRRTLITGSQPLPSPLNTSFDFKHSSHNSHSSLSQMVSESSVPSNTESSMKEQLGIKEDDEKQKQREKTADFLEREVSGISLDKSKSSEDPECDIISVKIADLGNACWVGHHFTNDIQTRQYRSPEVILGSKWGASTDIWSMACMVFELITGDYLFDPQSGTKYGKDDDHIAQIIELLGPFPKSLCLSGKWSQEIFNRKGELRNIHRLRHWALPDVLREKYHFTVEESMRISEFLLPMLEVSPERRANAGGMAAHEWMRDTPGMDAVDLGVQPGSRGEGIDGWAMEVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8B7</accession>
    <name>A0A317X8B7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_458008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="2">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471607.1">
        <property type="nucleotide sequence ID" value="XM_025607772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8B7"/>
    <dbReference type="STRING" id="1450535.A0A317X8B7"/>
    <dbReference type="GeneID" id="37109915"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF96">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="57"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="2">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="492" mass="54270" checksum="250FEACD88F3BD74" modified="2018-10-10" version="1">MFDTPFDCIVLDGTVVTAADIGRYDIGIRDGKIALLAPARALEKARAARVIDAEGAYVMPGGIDAHVHLSEPQLFGKGKAADDFTTGSRSAIAGGTTTIIAFSPQDQSEPSLISALDDTQKKAANAAYCDYALHLLLTNPTKQAINEFAQLRERGVSSVKIYMTYKDLQLRDNQVLDVLLQGRIDGVTTMIHAENGDMLTWMTEQLESRNLLAPKYHATSRPQILESEATNRAISLSQLIETPILIVHVSSPLAANTIRNAQTGGLPVYAETCPQYLFLTRKDLDRPGFEGAKCVCSPPPRDGETDLESIWTGLQNGTFTILSSDHCPFFYNDDVNGKKTAITKDEPLGRFRYIPNGCPGVETRLPLVWNANRLSPQKFVEVASTNPAKLYGLYPQKGALIPGLSDADLTIWYPSAQEPFPITNSALHHNVDYTPYEGHMITQWPRYTLLRGEVVWDRDNGGIVGQKGFGKFVKRDRSTFCSDQPEWDVEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8I1</accession>
    <name>A0A317X8I1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_507637</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471664.1">
        <property type="nucleotide sequence ID" value="XM_025609625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8I1"/>
    <dbReference type="STRING" id="1450535.A0A317X8I1"/>
    <dbReference type="GeneID" id="37111768"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="276"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="13"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="498" mass="53691" checksum="76D07776004686FC" modified="2018-10-10" version="1">MLRLHKPPRYVLASILCSCGGLLFGMDTGIIGPVTVMDSFVSRFGSESSAIHGLIVSSILIPAAVSSFFAGYLADKLGRPKGISIGVLIFGIGAALEAAAVHIAMFVVGRCIEGIGEGLYLGTLVVYICEISPPRVRGALTTGPQLLITLGLTVGFFTCYGTSRINSSFSWRTPFIILACLAFTFSVASFMWLTPSPRWLTLHGRKSEATAAWDYLGVSQAEREKVEIEQDQDNNTQVIATIPSRERAPSISPRQDRPMKHKLFDLFSKDVRTRTALAVFLMGMQQLSGIDGVLYYAPLLFEQAGLASSDASFFASGISAIVIFVVTIPALVWADKWGRRHSIIYGGIGLSVTMFLIGGLYAGNAVHSSTGAGRWVVIVCIYIFAVIYSLSWGVGIKIYAAEIQPQRTRASATSLAHGSNWATNFLVALTTPILLSKSSFGAYFLFGGCALITVCICTFFMPETKGRSLDEIEEAFKSKSLGSKTFLKALRPVTKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9C2</accession>
    <name>A0A317X9C2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_606328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471927.1">
        <property type="nucleotide sequence ID" value="XM_025616515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9C2"/>
    <dbReference type="GeneID" id="37118658"/>
    <dbReference type="OrthoDB" id="5139510at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="490" mass="55606" checksum="CB6DF1CACC929CEA" modified="2018-10-10" version="1">MSSSTCPPHEPLLLKRQIIPDHSPQDSKKARVKSAFHSNPVPCLQQGSLFRLPQEVLELIITFAAPYFIETCGGREYYFSYRTVADLALVCRRLYWIATPILYRSISLQLIDTWRLHHTLQANPTLRQYCRILFLEASVILTTPGDNVNIVQDIVSWLTSVKKLHIYCSYHYAEDDHVDYVGSLCDTLANATQNMHELDSLECIGVGFNWVMGAVQSSSLNALTIRSGRRIKKTLKLHPKKSQDSSVTNLSLDGCLEAPDVMAQLLQWPKALSSFHLTCFNVNDDSVKYSFSMFETWLRKHETTLQTLTLCGLPSDNASECAFNASAFPQLGSLRLSRWNMGTKLWLSDTDADKLLGPSLKTFTWDFRKLTDQKGAWKDFREEEENWLRKFARAAVEKRAALKSIRIAFSPYDSGQGTVGYPWGRMARVRDEFEPYGVIVTWDAPVLEGDDWPGASPQYVYAVDELWELVSDDCPSPGEMETLLQDDCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9S0</accession>
    <name>A0A317X9S0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IgE-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_507746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471712.1">
        <property type="nucleotide sequence ID" value="XM_025609629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9S0"/>
    <dbReference type="STRING" id="1450535.A0A317X9S0"/>
    <dbReference type="GeneID" id="37111772"/>
    <dbReference type="OrthoDB" id="5430620at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052820">
        <property type="entry name" value="PhiA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42047:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016253053" description="IgE-binding protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="19116" checksum="8D5660FD66F65E9A" modified="2018-10-10" version="1">MKFTLAAASVLPFLAAAAPSQPKAARDTTTFSVMSARSGSPIHLLPLNAAGGAFYLGGETSSYCPIASGCPAGTETVFAGDGSSLDVEVPGGQQVYVNPSGALSFTVPHSAYIPTGSSTGPFTYAPSKPFGTWSFGKGFMACPTKDSKWQVFAASQNATVPQGNVNDCLGFDALAVAGNGSVAAWEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9V1</accession>
    <name>A0A317X9V1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_562961</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472085.1">
        <property type="nucleotide sequence ID" value="XM_025614323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9V1"/>
    <dbReference type="GeneID" id="37116466"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF41">
        <property type="entry name" value="MFS TRANSPORTER OF UNKOWN SPECIFICITY (AFU_ORTHOLOGUE AFUA_5G09940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="44"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="495" mass="53076" checksum="DAB7992899514CCB" modified="2018-10-10" version="1">MRDGHTDDTLSVVSRVVTAEAQQQRLGIPEPAPPDLSQAKQYTITCLILICNFIQFLSMFSTVAGGFAFNAKLGHEAKPGQANWMAAAYSLPQSAFVLITGRLGAIYGHQRLLLLGSFTITIFSLCNAFCNTYVSFVAARALTGIGGGIIMPNAVATLTIMVPPGKARNITLAIFTATPPVGALVGALLVGAFLQYAEWKWHFILIACLGVPVLAGLFFVLPHEEPVDKGGKADLIGAFLGLSGLLLFNIAWNQAPSGGWQTPYIIVILILSSRFADEPIMPLAVFIAPSFNALIFVVLFIYMSVGISLWYMVAWQQLIRGWTVLHVAIGWIPYGIGASIAVTLAAWLITVLEAQYILSLGCLTSIVACVLLATMPEQQIYWAQVFPATVIGSLCPDFVYVAAQIIASNSVGKREQGIASSLIGTLNLYGNSLGLGFDGTIEVQIANSTNSEATGIRAGLWFGAALGITAPLIDLEFVRMNKNDRCNSNEQCHCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9X8</accession>
    <name>A0A317X9X8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_459932</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470479.1">
        <property type="nucleotide sequence ID" value="XM_025607865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9X8"/>
    <dbReference type="STRING" id="1450535.A0A317X9X8"/>
    <dbReference type="GeneID" id="37110008"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052840">
        <property type="term" value="F:inositol diphosphate tetrakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18538">
        <property type="entry name" value="PFA-DSP_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000035">
        <property type="entry name" value="Tyrosine phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="11">
        <location>
            <begin position="39"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="222" mass="24941" checksum="9338CFD5BF19F466" modified="2018-10-10" version="1">MANPLTEKDSNSSLKSVHVARHKASSIESEPAQSELPDNFGEVVKGVYRSAFPHPWNLHALKKLGLKNIITLVDEAYTSSHVVFLKENGIAHHRILVQANKDPDVKIPDTVMCRILELLLDKSNHPILIHCNKGKHRTGCVVGCFRKLQGWESRDIIDEYFHHSYPKSRLLDEKFINEFDASQLSQSAQASGVKAWKPSGHFKLPSEENDKASPTRLLPPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA47</accession>
    <name>A0A317XA47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein PSF3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_341611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470151.1">
        <property type="nucleotide sequence ID" value="XM_025607041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA47"/>
    <dbReference type="STRING" id="1450535.A0A317XA47"/>
    <dbReference type="GeneID" id="37109184"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21693">
        <property type="entry name" value="GINS_B_Psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055221">
        <property type="entry name" value="PSF3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22466">
        <property type="entry name" value="PSF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF3 N-terminal" evidence="8">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="74"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="178" mass="19807" checksum="08971ADEC8D3CAEA" modified="2018-10-10" version="1">MSYYDIDAILTDSQKLPCTFELEVPGLGILEGNPGENIKAGTRIDLPLWLGEMLSIGARLGTSRLVTLDLPSALSERVMNALKADPRTVELRSLAPHFYSLSERILELFEEEEMVEVLSNTFKKRSAEIADHAHNPQGALGQGADFLRGLDETERQLFRVAHDSAKETRIWAGEAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAR6</accession>
    <name>A0A317XAR6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Permease of the major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_454805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472256.1">
        <property type="nucleotide sequence ID" value="XM_025607620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAR6"/>
    <dbReference type="GeneID" id="37109763"/>
    <dbReference type="OrthoDB" id="10262656at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="12"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="512" mass="55610" checksum="6F3E2DE9CC32013D" modified="2018-10-10" version="1">MLEKTPRLPVRQLVILSICRFAEPVVITSVLPYLPEMIEYVGVPKSDVAKWVGITSAVASICQAAMAVSWGTASDSVGRKPIILIGLTCTMFFSLMFGFSQTLGMLVVSRAFLGLMNGNVGIIRTMVAEMVPEKELQPRAFSIMPLVWTIGSIFGPAFGGALARPAEKHPDLFGDSVFLRRYPFALPNIASACFFVVGITTGFLFLQETLAAKKNHRDYGLVLGEALTSSCASRRKSHVQDGERAALLGPRKKKPVKRPSWAEVFSPQSRRVLLAYALMSMHTMAFDSLLPVFLHNPVQEFEGNPDVRLPFKFVGGFGVDSQTIGIFYTLIGIIGMVVQFLVFPWAAKRYGVLNCVKVVATVFPILYLLTPFTALVPEPLRNITVFFLMLGKLSASIFGFPCTTILLTNSATSLSVLGTLNGVGTSVSAIGRAVGPAVTGQAFTYGVKQGYILIPWWMLAVFGALSAIPVFYTEESDGFHAEEEEVDANEGEAEVEEREEGQGYGATAVSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB39</accession>
    <name>A0A317XB39_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_580991</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472595.1">
        <property type="nucleotide sequence ID" value="XM_025615361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB39"/>
    <dbReference type="STRING" id="1450535.A0A317XB39"/>
    <dbReference type="GeneID" id="37117504"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14516">
        <property type="entry name" value="DSP_fungal_PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000110">
        <property type="entry name" value="PPS1p Protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047949">
        <property type="entry name" value="PPS1_DSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="502"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="570"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY95834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="680" mass="75921" checksum="65AE689A5D5DFA82" modified="2018-10-10" version="1">MATVVVQQHTLRHSTPPPTGLTPALSLNRTSSPIPNKHIPVCPTGPSPVSSRTPPSATKDNNKDQSTFSLLYPPDGFLRLTQSPALYSIDLKTLAASLEYLASQPLPDPSLVFPWLHGLHPENHLQVGFFTNRRRSLRRTPKCWRGITIVKVGGDLSTARIKGAVSPDEILVPSSVEFLPVDPREGFSVRNFQIQTAKLAPLSDIVIYGEDGVPKQQILEIAGRVATAQHNWRVKHDPDHSFPAYNTFVLACPFSEIERRAPQLVAISSKGQLTGQVVDFFQWERLEMCEMSKASEISTNVWLGPTPDYLLRPGSCGPAPTENFDLLIEASELASIPGPRFLAKLNKQLDEGPQKLEFPSSGSILLPAGEHREVDDLVNTVRWIYYLANPDEPDHKADADGDIQMIPLTKTARKILIHCPDGYTESSLLAIAYLMFAEGISAPNAWLKLHCEKKRNFFAYPSDISFMSSVQGRLMQESPATPSHKLKSLPDPSWFRYCDGSLPSRILPYMYLGNLSHANNPEMLCALGIKRILSIGETVSWSSSDAAKIDPKNLLHITQVQDNGIDPLTQEFDRCLEFIRQGKSDGMATLVHCRVGVSRSATICIAEVMASLGLSFPRAYCFVRARRLNVIIQPHLRFVYELLKWEELQLRKRNKPARRELEWATVAREIALMNKPYSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBR8</accession>
    <name>A0A317XBR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_530509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472536.1">
        <property type="nucleotide sequence ID" value="XM_025610686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBR8"/>
    <dbReference type="GeneID" id="37112829"/>
    <dbReference type="OrthoDB" id="3565477at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016287345" description="GPI anchored serine-rich protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="23329" checksum="676C16E3AEB84492" modified="2018-10-10" version="1">MRFSVATVALFASLVAAIPQDVETVYSTEDVTIVSCAPTVTNCPGTLHATSTPEAVAASTTGGPEGVSPVATTSSASEVTSVATTPAAGSSPAGGSPAGAAPSAPSSGTGAAPSGAAPSGAAPGGAAPSGPASGAGSVPSGAAAVGTGAETTAAPSVTVIPVTTCIPTVIMSTSTIGAGSGSGSGSGVGAYGSGYPGGKPAKSSSPVIPSGAAAWGSGYPSGSATPSASAALYTGAASSVNGNGFAFAGAAAAAAFFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC22</accession>
    <name>A0A317XC22_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_2233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472955.1">
        <property type="nucleotide sequence ID" value="XM_025606232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC22"/>
    <dbReference type="STRING" id="1450535.A0A317XC22"/>
    <dbReference type="GeneID" id="37108375"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY96194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="57096" checksum="F17D81F4E214F647" modified="2018-10-10" version="1">MDVLLLSPRQGIPPHMRPPEPTSPVSNAEKARLICAYMHETGIWCETTDSERHFTVKSIHEMMGSAAFVAAAMALASRQLDHLERQQRPVTLELHQYSIRLLLRQHPAKSDASMLAACTLLCVYEMMASEVHEWRRHLKGCAGHLQAKRWNGSSEGIVKSCFWAFARIDVWAAFISGNSTLIPTDFWIDNMSFESVAAKGNVDDYCNMANVIFAKIVNLLAAGYHEKRYYTALATVSNLWSELQAWCRLRPKDVCPLLRDHSPGQVSPTVLYSRSSSICGNTFYHAGCILLLQTGILPVVTGGVSLLQETKSAVWHARELAGISMSNPSHANWVNHLQPLFIAGTVFASSETGPGMKNARESQKGSIPPSAHGSRETLNTTGYAPQREDSYAEERTLLLNHLARIERETGWKTSDRTATLRALWVCSRAMPCNLCFALIGIESNYTACSIVGIRSKASIGRLLCLDANKVRRSEENPKVHSFLWPVTKAYVPVTGDSINQWQSTPERSKTPFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC97</accession>
    <name>A0A317XC97_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_532121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470921.1">
        <property type="nucleotide sequence ID" value="XM_025611059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC97"/>
    <dbReference type="STRING" id="1450535.A0A317XC97"/>
    <dbReference type="GeneID" id="37113202"/>
    <dbReference type="OrthoDB" id="2398441at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038886">
        <property type="entry name" value="E3_SLX5/Rfp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY94160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38983" checksum="6EE02D4CA2189FE6" modified="2018-10-10" version="1">MSDDSGVLFVGSRPRKRTHREMSETSSERAFAGPSSSSRTPGSSLPPLRRYPGDGLDFRRPVTSASPQIDEVIDLTNEPDTPEQTARHQPPFPAEISRRPRPRPRPRPPRFPRDILTEVVDLEEEPDNGNHQDHPDSPEVQFVGATVLRPQLPPLERQPPLLPYNRMPTPMWRDVVLPPTPPRQPGRFDYRPFTLMRIRDDFPRLSEMESFWIGNGRAGAVDLTINLDVDGPLGLDYQLTGVSPERAPGNSYKPPSPPPEGFTRNIEEDDVVICPNCEMELGMGDEVKQQIWVVKQCGHVYCGECASNRSLSKAKKTTSKTKAFSKCQVIGCHKPVSSPRSMFQIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCD3</accession>
    <name>A0A317XCD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD dependent epimerase/dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_553527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471379.1">
        <property type="nucleotide sequence ID" value="XM_025613662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCD3"/>
    <dbReference type="STRING" id="1450535.A0A317XCD3"/>
    <dbReference type="GeneID" id="37115805"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF8">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34866" checksum="9E13B4DC888544CC" modified="2018-10-10" version="1">MDLIKNTLYGYPKPPPRVRTKPLRVICTGLPRSATESLRNALAQLGYEPYHGWDLIFDEADYIQEWSALVRRKYDGAPDGDFHVTAAEFDALLGNHDAILDSVPAMFAAELIEAYPDAKVIINTRKDLDAWHKSIMKTVVAETEGSWKVWLVSTFNAEMFWLWETYFTYAYIGLFRTPKGKSASHAIERNGKWVYRDQCNMVRGMVEKERLLEWSVEDGWGPLCEFLGEKVPDEPFPNGNDATAFKKRSGEKLMPRVQRAMRNIALTATSVGVMGVVIGLAVRERGMPWKAIGSVSSAIGSGWAAVKGLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCF2</accession>
    <name>A0A317XCF2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_551903</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472950.1">
        <property type="nucleotide sequence ID" value="XM_025613562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCF2"/>
    <dbReference type="GeneID" id="37115705"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016337604" description="Glycosyltransferase 61 catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="2">
        <location>
            <begin position="189"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="444" mass="50242" checksum="C8F07ADBB4849517" modified="2018-10-10" version="1">MRRLLLSLALSASLLILLLKALHVQASHQPTPSVLPNSPPLPSHTPNPFHPLHLTECTSTTPPYYAPCLAQTLPHAASGKELLYPAFTTSPPLFAASRPHDAETWWNTTWLLRDRAYKLDTRLRYPEKHGQIYVFENVTLSTSTPFDKWSMDSCMSSFAPTSYVLPSSNTPTHESVLLANIPDSWSLQHFLDRAMRVVAQSRDYQPGYVAIGRGGDKSVKELWQSLGYPEQHVLHRDTSFVASQMIWSCRAPLVHPWLTHQSLSLLAPDSLHHVPLSDRKVILYMTRSNGLTRNGGRQVLNEDTLLVGIQSVLDRRGQKEKLEIFNHGDFSDMGTFIRYLQQNVKAVIGPHGSALHNHFWTASDTLVVEFQPTSRPDLTFYESAKMRDHPYVVLMEEPVDEMHNMLVDVGAVVEILEERLGRELEMGDRVRLAYDWEADELGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCH1</accession>
    <name>A0A317XCH1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">67 kDa myosin-cross-reactive antigen family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_510532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471001.1">
        <property type="nucleotide sequence ID" value="XM_025609736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCH1"/>
    <dbReference type="STRING" id="1450535.A0A317XCH1"/>
    <dbReference type="GeneID" id="37111879"/>
    <dbReference type="OrthoDB" id="545169at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050151">
        <property type="term" value="F:oleate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010354">
        <property type="entry name" value="Oleate_hydratase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417">
        <property type="entry name" value="67 KDA MYOSIN-CROSS-REACTIVE ANTIGEN FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G09970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37417:SF2">
        <property type="entry name" value="67 KDA MYOSIN-CROSS-REACTIVE ANTIGEN FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G09970)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06100">
        <property type="entry name" value="MCRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="2">
        <location>
            <begin position="120"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="912" mass="103428" checksum="90F7E3B3044AB2BC" modified="2018-10-10" version="1">MSAFKSLLATSTIPSTFDQLPSPHLTIALTLILAYLLLVSALRFQRVRQLRHQYPHYATRASMAQMTDHDAWAIQKNILQLEFPTTAIKALQFALFRTYGTPTISSLLLQTSQLSNPATSFKRYADTGALIGQFMTYAPTSPRARTAIARTRFLHAGYRASGKILESDMLYTLSLFATEPIRFVQRFEWRDMTDLEQCAIGTYWKSLGDALGISYGLLPSGENGFRDGLHFLEEIREWSAKYEMENMRPDETNRLVADKTMDVVVYGFPDWVRGIGVRLATCVMDDRLRKAMMYDAPPVLHRKIFAGIVGLRRFVLRYLAPPRPDFLRLEVFSRTPNEKGRYYVRVWKGMPYYVQPTFWNRWGPGAWVTWAVGLPLPGDEGDTYYPHGFDLADLGPRYFEGKGRQSVREIEDANLPPSRIHILETLSQAGGGTVSSGDHVNGYDYRGGGMPPFNDVCMEELLDLVPSKDDPDQTVLEEINQYWDTEAVKDTPHTRFLTRHKHSIERITAKEASVGLRDRVDLFMMGSKAEKSLGRTRICDHFSKSFFRSGYWLILSTTFGIKPTHSAAEFRRYLQHFMHDIHNLNRRQRLDGGRFNRHESIISPIAQFLRSEGVDFRFHTTVTDIITSPSSSDPHRVSAIKAIHENEPEHTISLSPRDIVLVSLGSVMSGSTTGTNTTPPSLELMEIEKDLDENWLLWLELSTKNPIFGNAYNFCTRMSESRLESFTITLSTPDFFTRFTTLTRDKPGSSTLTTLKDTPWLISLSLPQQPLFPNQPPNIQVLWGYAMYPDREGEFIKKPMLECSGQEIFEEILHQLKFPVREILNHAITIPCVVPRMAATLLPRTDGDRPRVIPPGIVNLGLIGQFVEIPSEVAVTMDYGVRGAQMAVRQLMGLGVRKPSSKRSSTISLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCW1</accession>
    <name>A0A317XCW1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_619585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473217.1">
        <property type="nucleotide sequence ID" value="XM_025616870.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XCW1"/>
    <dbReference type="GeneID" id="37119013"/>
    <dbReference type="OrthoDB" id="5423926at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="612"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="964"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1171"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1356" mass="143890" checksum="4CD7B8E0FCC3B376" modified="2018-10-10" version="1">MFRRKRSSSQHQHPLSASSSQSAQSAASHAFLKSQPSSSSLSSAAAAAALRSLTPTPTSVENVQTKRMMQRRASVSSQASGVPSLRPTSRNGLRRASSSASMSNRTFRDQSPRRPASSSGPVDTAPPLPSIPREYTARNNKVQRSTSVGPSQRPSPRAKPSAGRGMSVDRGSATRPATRAPGSTPSPDLRRPGSRNSVNFSYPMNSRPNSPDGPADALDRRDASTAVSLAGQLSSPDSPKSINASPRSARMPKSMGVSPGSPGRGAQSVGTAVAAAQAAIVPRMQDITQVHPPSAPPRISVPREQTIPDQAPSQPAAPPEQKQPPRPHLVKRPSTVPEDAKGEERAESDVPGQRTVPPRVGSVTPDAPVTVKFPPTPDGGKAQLLSPPVSPPEPTPPADVGRDNKPSDVRQTGSPGRSAHFSRHLLVAAFAGEQLHQPPPRSLSPAKSAMKNTRKSSLSPEGRTESVLRPGPPLSELSDGTSVASDEGSKQGIRKKPIKVSFDDEAEVVGVAASPPTSPDEAIPESLPEKPKSKSNWFSGKRKPTPLNTEFDEVLKPRRALPSFGSIRAGRDGDAQEKTVPELSDNESTTSSDSPAEAFRWSFSNDHAVGGLIADNQSKDAEKRLPPMMLANAAESESEAEKSPQQSHCTGQPDLQETSVGPAAISDVPSHPSQGRTPEATLAVPNIMVQPASPDPSKARSSLEWCEVPGRFPRSSLEFDPKANGKGKAKDKPTRHVAGDGASGIVDDEESGDDSGDSVYSDAEEGLEGNGYGSINAIVDDETAAAPAALTSAVPTLPAETDAIEGKISPPPTDWPNIPDTCQIARTGSTLPDKGMAPIPESPGSSHEPLAFSSPYPPFPTQSQSRRSSSQGDLSRSSSVTVRPARHSMLVGANNDSSLGDQTLRGVNGSVSSQREASHLRQRFPQDNIPKRPVSWSPALAKGASPDLDRASYVNGQSSPASPRPLSSGSDSSSSFKRASRHARVDSTYTMRRTMRGNTPGRPVPNRATSPPVETRPVSSEAGLGTMRTTLRGNSSKREKPSFFSNSKAPKSKLTKASGGVFASRFPDSDSDDEGYEAWRSRHRYEDSSDEDTRSPNAMRPVRGIPRRQGARDGDSTELEDSSDDEHRAPPRAIPQSPGKSNPSRDPALAAVAKSRGMTEDELDEFLRQPNRGRKPGLFHRFSLRKSRSPVNRVQVKPSVDSFARSGPLSERTRLDQEPARGDPPLPGPQSNIVTTITATNPPPPPSKLLRRPSQRSARGDSWPLRSDRKESRTESPAPASGPSERLATVDEASLNGSTVVPPTPGPVAKENENPSTGVSGVKFEGRSANMADVTISSSGRKKRFPRLRKALGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD37</accession>
    <name>A0A317XD37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_571514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472812.1">
        <property type="nucleotide sequence ID" value="XM_025614872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD37"/>
    <dbReference type="STRING" id="1450535.A0A317XD37"/>
    <dbReference type="GeneID" id="37117015"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY96051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="244" mass="27110" checksum="C0D58D9C95AB1405" modified="2018-10-10" version="1">MTTQQPFSGSADSRKRVYKACDRCRVKKAKCNGFRPCVRCTSDNAICFYGAGHKAYKKSYPTGYAEALEQQHDWLVDGLQQLYRRMCDGEGWRGGPVSLDHHGHPCSHELLTRLGALDESKGEHFEEDTGAMQQRLWSANTAQATVRSDNGLNPLNHPFCLPSLAPRQPPLPLACVAPSSVWPPIQAFSFPVDGDEIPTPMPNPMLGMTEIRNSPNADMGHKYSWGVDPVRHTDVSPAFLFEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDQ3</accession>
    <name>A0A317XDQ3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 alkane hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_19123</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473517.1">
        <property type="nucleotide sequence ID" value="XM_025606037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDQ3"/>
    <dbReference type="STRING" id="1450535.A0A317XDQ3"/>
    <dbReference type="GeneID" id="37108180"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY96756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="514" mass="58592" checksum="D5EA9AC377CCC14A" modified="2018-10-10" version="1">MDPGKSHYPVVALASAVLLLWYTATYLQRKWTQRRIAKANNCQPPPTYPRKDPFFALDNIHEQLTYARKHKLLERIVERFKENGNTYQGRRLTTPIIITCEPENVKTILSLRFKDYGLAGRINAAGPLLGHGIFTTDGEHWAQSRAMVRPNFVKDQVAHLDIFEELMDDLLPLIPTDGGTVDLQELFFEFTIDSATEFLFGHSVHSLKKRRAGIRDSTEQDFAGAFNYAQEAIATNLRLGKLRHFRRDRKAEECNRICHNLVEQFVDSALRVRGRYDEEKALTAGDSHGAKEKRKYLFLHGLAQQTGDRRRIRDELMNVLLAGRDTTASLLSNLFFMLAKNPRIWNKLREEVASLEGRAPSYEQLRNLKYLKFCLNESLRLHPVVPANARFANTDTILPVGGGPDGKSPVFVPKGCTVAYHVYAMHRREEFFGPDANEFRPERWADIRPGWEYLPFNGGPRICVGQQYALTEAGYVTVRLAQKYSVLESRDPGPWEEGLTLTLCSRNGTKVGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDQ8</accession>
    <name>A0A317XDQ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_529700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473072.1">
        <property type="nucleotide sequence ID" value="XM_025610505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDQ8"/>
    <dbReference type="STRING" id="1450535.A0A317XDQ8"/>
    <dbReference type="GeneID" id="37112648"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="352" mass="38698" checksum="FAFF42B4767FDB04" modified="2018-10-10" version="1">MSNGLSYLQKMRKPQLAEWAEITDLQNYGDYTKPDLAAALDQHLQANQSIFNSDARLADYYKKLLQSPRIYSPTKRIPKVEASPSPSEAPRSVRRRATKAKLEERTPSEESELPQTPGQALVSIQPPTIASPAIASLVQELPPSPAVVTDAIDRQTAAWGKKLSDAWTGTGVQERTDSLRSNLSSVKAFGALLLALEAIGLFQTTVPWNYVATLKLPQSLQIADYQVWIPDLFVLLEGHFWAAVTLWLLTSLVLPLTTAYFFNISLQAAQPGSPTFSARSPFAHTSFDPLSFYISKAVIAYIVYVEQFSFWSLYQGLTIERLEASLPGGVYGAVAGCAIGVIGTLYEAILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE59</accession>
    <name>A0A317XE59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribosomal protein L24E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_454115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473222.1">
        <property type="nucleotide sequence ID" value="XM_025607598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE59"/>
    <dbReference type="STRING" id="1450535.A0A317XE59"/>
    <dbReference type="GeneID" id="37109741"/>
    <dbReference type="OrthoDB" id="5599902at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058345">
        <property type="entry name" value="DUF8032"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949:SF0">
        <property type="entry name" value="RE27538P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22949">
        <property type="entry name" value="WHITE COLLAR 2 PROTEIN WC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26087">
        <property type="entry name" value="DUF8032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="DUF8032" evidence="2">
        <location>
            <begin position="289"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="739"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="772" mass="84524" checksum="4EA49889E937E2B9" modified="2018-10-10" version="1">MTGMVQTDLAHPSAPKYKDEPVDDPHRHPGPQPPHLQHPRPTALVQPQKQPGSPHQPPTTLPPGSYAPHTLGNGVLHHQHPYGPPSEPPYYPPHPSYTTATAPSQYSSSGPPEMMATATQMQRPYPPIYHTPQSSSPASVASQTHEQHNRSLYTQSPQMTSQMYTYQPYSPINPVQPPPYGPNTSPQNHSLTSQSLMMPHSTSSAQLPHHPPQASSGNISSSPNTSTAQQPTPPQRTMLNPPHPTTTGAPISASTVHHQSSNVGASSSAAPGPIPATTPLVVRQDSNGVQWIAFEYSRDRVKMEYTIRCDVESVNVDNLSQEFKTENCVYPRACCSKDQYRGNRLVYETECNAVGWALAELNPALRGKRGLIQRAVDSWRNSNQDPRLRSRRVRRMAKMNKRQGIPVQPPHMAPSTPVAPGVPSASSMPAPAPRPSLGPLPMGPPQLHHHHAQPEGSAGHEEVSGTTDFTNGTSRPPAPDGLPQPGPSPTDIRTAQVFHGYSSYPTPATASGGPRGPSIPPLLRDSGIGSIGRHPTIATSSSRIEEVDDDDDEHNPSNDALFGTLPEGKRRKFILVDDNQRGCRVRVKVMLDQVDMDEIPDSYRLSNSVYPRTYFPVQMRDPPGRVLPGNRYIKDHVGIDDGDDDDESSTVGRIMVPAPQIDGDGEIAVPRLSRGRRRREVLLNDLGYRMSWSQSRVFAGRMLFLQRSLDAYRNKMRSTMLAAGQEPVSIPRHFETRAGKRRFLERKRRTAGAPVRGAGLSASQRSAEEVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEM4</accession>
    <name>A0A317XEM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_530164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473566.1">
        <property type="nucleotide sequence ID" value="XM_025610626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEM4"/>
    <dbReference type="STRING" id="1450535.A0A317XEM4"/>
    <dbReference type="GeneID" id="37112769"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="105"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="473" mass="52119" checksum="6F8ED1398343F014" modified="2018-10-10" version="1">MDSPAVYTTDDGCIDCNSCCDSLRFRSDQPQKEIIVDVHSVICIVPKDNCGETVYSLLYLRNDAEATNLKSEPLLLDNILLATVPRPLSNLLCAQLPPHLCSSRLESGGLDIIVSTTSGTGTGVTFCNNILRPLLSHLGISQYEIHETQSTQTITELCHARFIPRAMERLPQTILLLSGDGGLTDIIDAFHSTIESLAVPPTIALIPTGTGNAMANSLGLFAYPTTGLVALLRGTPASIPTFSADFSPGAQYIVDEGRQKVPIFRNLKSDYEHPRVYGGVVASWGLHAALVADSDTAEYRKFGADRFKLAAKEILYPSDGTEPHRFRGAVTLFKRDSHTESKRQDLLGRNEHMYVLASLVSSLEKDFMISPLSRPLDGRLWMVHFGPMSPSSVMEVMTSAYQKGQHVGDENVSYNDIEGFRIELGELNERWRRICIDGKIIIVETGGWVEVHKDPKRLLNILLLQNIPKLGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEP1</accession>
    <name>A0A317XEP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_619318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472898.1">
        <property type="nucleotide sequence ID" value="XM_025616853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEP1"/>
    <dbReference type="STRING" id="1450535.A0A317XEP1"/>
    <dbReference type="GeneID" id="37118996"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="19"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="718"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="743" mass="82214" checksum="B52A274B5403AF61" modified="2018-10-10" version="1">MPPKRVARLSTGTQKLTKSCSRCRASKLKCDRKEPCIECLKRDIGHLCTKDERQPRAKRAKVTPSVDGSDSQVQIADPGVNRSTSQPKDSEAEETVQILENYVDDASLERTSCVVAPDLPNPYWSNPRQVDQVSLLREIIDSVPEIDIIFLLHDVFLTRCQAPLGNVVHTPTFAKQVERFCDCLRLPLEERVMALLDKMSMEMISCHLMALVLGLAFHPAPTILGWSATPLTLRVEELRGSDVHAKAWRSLALRCLQGHVSLFCGSVAGLQAAVMLLLDGHGDPSTLDVILATAIAGARRLGLHLLGDAKLAAASIIGPESTEPHIRTEIGIRIWWALVMRDWCRGQSLGYYSIHPAQFNTRMPLHINDDDLRLPTEKVDAYGHITERPRSEFTMLSYTLYALELAVLVRESIDIRGPVRQSNPDQMHKHLNKRYEELVVGLPSHFRLGSSIGLNATGPLAAIPVHRWILHQQLWSLFLRLHRGSLSTLGGRMSCQLLAQNIISTHAQIKSRCTLCRSLTTGETQLFNAAAVLVMGLLFSPSDGDCSGSQLARMMSRDKVREAIELLQTSEVDSESPSLTPMAWKTAQRSIHALEALMKLEEEVSGDEDPNADESMFRNGASVSLKSKVMNVLKSLHNPATEPENTNIEPFSFDMTTPFPMDNTGFHETDVLPGLSNDPSCSFWQFLDFDFFPGLTGKDIPPLVTDQQGFGGWMPFSPSSGLAQSSTTGTPGFLDTEQSDLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEX2</accession>
    <name>A0A317XEX2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_529638</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473008.1">
        <property type="nucleotide sequence ID" value="XM_025610487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEX2"/>
    <dbReference type="STRING" id="1450535.A0A317XEX2"/>
    <dbReference type="GeneID" id="37112630"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF76">
        <property type="entry name" value="CHAIN OXIDOREDUCTASE_DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY96247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="222" mass="23853" checksum="67994222E1A3CB38" modified="2018-10-10" version="1">MTYLSTSSKPAINDLRTKINQLPHTPTTWTCQTDLSSLTGASEIISTLKTHLHPTPLQIDILINNAGIEIINTLQDTTLEDYDKVFNLNVRGTMLMTQAVIPYLPPKGRIINLSSVGARYGFKNISLYIASKAAIEGFTRAWAAELGGDGTTVNAVAPGPVPSDLLDRIPKDIVDLQKATTPIEQRLGTTGEVANVVAWLAGSDASWVTGQVVCVSGGWGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XG06</accession>
    <name>A0A317XG06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_453612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473558.1">
        <property type="nucleotide sequence ID" value="XM_025607574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XG06"/>
    <dbReference type="STRING" id="1450535.A0A317XG06"/>
    <dbReference type="GeneID" id="37109717"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="82" mass="9472" checksum="EDAE68CDA8EA8AEA" modified="2018-10-10" version="1" fragment="single">IIQLIQIYIKNDKAVRINNLDYWYNCPAAIKFLSVMISASLLGVLKKTEVCCSRSDLIEIIWFTLISARTFYSYAPQSYTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XG50</accession>
    <name>A0A317XG50_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_480821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472939.1">
        <property type="nucleotide sequence ID" value="XM_025608839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XG50"/>
    <dbReference type="STRING" id="1450535.A0A317XG50"/>
    <dbReference type="GeneID" id="37110982"/>
    <dbReference type="OrthoDB" id="3233595at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF5">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="39"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY96178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="402" mass="42719" checksum="54D3D2F167A17203" modified="2018-10-10" version="1" fragment="single">MPSPAPCSPYTNPISTSTTILTLLPSIPPNMKEIINLPGPSTKLIDSPIPTINDDQVLIKVVVSGSNPKDWKVAELANDPESAFYERYAHVRQGLNQGDDITGVVVKVGKNVVEFKEGDRVAAFHEMLTPGGSYAEYAVAWAHTTFHLPGEVSFEEGATIPLAALTAVISLYHHHAFPTPWSPPSATTTSTPFLIYGASTAVGSFAIKLASASNIHPIIAIAGAGSPYVETLIDPSKGDIIIDHRKGIDSVVREVKSALALPPSQGELILNDTLDTIISPTSISTIKQVLNPLGGKVNTVLPLPDPNPYPSGIEASNTWVSAAHEVVGAVDCRDLCFVFCRWFTRALALDAQAQGRKKMFSGHPFQVREGGLGGVEGAMRDLQAGKASAVKFVFRVGDTPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XH36</accession>
    <name>A0A317XH36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Regulator of volume decrease after cellular swelling-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_619525</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473151.1">
        <property type="nucleotide sequence ID" value="XM_025616867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XH36"/>
    <dbReference type="STRING" id="1450535.A0A317XH36"/>
    <dbReference type="GeneID" id="37119010"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY96390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="30551" checksum="41AB1CAFCDDB95CE" modified="2018-10-10" version="1">MEPLTTPPDTTTFIPLAEHQSRTPSSFHSGPAVLYSHHQNCKLVILERDLLAVPALGALRDSPATANGTSTTTSDEETEVVIQGVNVWVTSEKFLLHNPTTNTGLSIPYPTIHLHAIQRLQLPSSPGEEVQGLYMQLAHPSPQNYTSGDDEEEILTITIVPGPATQSQEEEDEKDETPTQTLYAAVSACSNLHPDPVEPGDEDEDDEEEGGLLQTGLVSMGSTEAGGLPPPVEGSSGWITAENMHEFFDEEGNWIAGGEEPNLSLGPGAGTVRHREDGEEGGEGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XH47</accession>
    <name>A0A317XH47_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_571017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473539.1">
        <property type="nucleotide sequence ID" value="XM_025614851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XH47"/>
    <dbReference type="STRING" id="1450535.A0A317XH47"/>
    <dbReference type="GeneID" id="37116994"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000090">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF87">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="559" mass="62979" checksum="CC9C303D56582463" modified="2018-10-10" version="1">MPAKLFYLLGEPVATAREIEVDLALDCDALKHLIAAHFAIVDPNGIGFQSEYTIFTNVAEIAASAEPISITIDGNPVKEVPGPKGLPILGNFFEIYPDHLGNHQRLFEQYGPIFKTTNYGRTVYHTNDPELSAIIFSESDFFTKKINESHPLHAIKNKEAGVFLGDTDTPEWRTAHKFLPPAFGPKAVRHYAPVMQQTVEDAFKVFDAFDEQGEAWNVYQYMLKLGSQAVGKLVLGIDFQHFSTMNAPPHKLILLIAESLELNKKITARGDWYAKLPFGDPKRLKDIRGQVWAIVDESIQNASRGGIEDLPLQDAALKAHNMIDYAIRATDNKGEKLPKTSLIQALVVATGAGFTTTSSLLSWLIYSLVSYPGVQDRLLQELVDNDIDADTQITADLTDRLTFMDKFIKETQRRHNPSYQPGRTAKVDMILPGGYKLPEDSVVIGALHHLHNNPNVWDNPTRFNPDRWDTEEVKNRHKSAYIPFAAGPRMCIGFNFALQEVKVFLPKLVYRYKFIKETEGPIEYDPMFQLIRPNNLYVRAERRVKWPPKTEGPMSTASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVA4</accession>
    <name>A0A317UVA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_540759</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000055">
        <property type="protein sequence ID" value="PWY65944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461523.1">
        <property type="nucleotide sequence ID" value="XM_025612985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVA4"/>
    <dbReference type="STRING" id="1450535.A0A317UVA4"/>
    <dbReference type="GeneID" id="37115128"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="83"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY65944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="460" mass="49995" checksum="E202DCB11961A5A8" modified="2018-10-10" version="1">MASRLPFHRLSEQHLRTLPRHASASRSLHSGRCRNFTSVALQNPAKASLRPTSGLQQIAVLGPNVSRFNIVPFWRSQIRTYADTVVKVPQMAESITEGTLKQFSKQVGDYVERDEEIATIETDKIDVSVNAPESGTIKELLVSEEDTVTVGQDLVKLELGGAPETRKEEATEKPAAPAAADKPTASEPTQHKAPEAPKAPSEKLTTPEPSPSKKAEPTPTKSQAPEDAKPSVGGREERRVKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSSLMEFRKLYKDAVLKKTGVKLGFMSAFSRACVLAMKDVPAVNASIEGPNGGDTIVYRDYVDISVAVATEKGLVTPVVRNAETMDLVGIEKAIADLGKKARDNKLTIEDMAGGSFTISNGGVFGSLMGTPIINLPQTAVLGLHAIKDKPVAVNGKVEIRPMMYLALTYDHRLLDGREAVTFLVKVIHPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V051</accession>
    <name>A0A317V051_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_579498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461982.1">
        <property type="nucleotide sequence ID" value="XM_025615271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V051"/>
    <dbReference type="GeneID" id="37117414"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="68"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="212" mass="24116" checksum="B999FE5D628961B8" modified="2018-10-10" version="1">MTSSTLSNSPLRLELATLDDLPEITELWYNAFTTPGLRAIWPDTPGVRQWWHTANEHDMLHKPREKYVKVVDTTQNGRIAAYAKWSLQTAEERGARWPAWHPDMDPVRNDAFLHQLESCRATLVGGGRKNFYLDMLATHTDYRRMGAARLLLEWGCQVADEEGVPIYIDASQAGKPVYERLGFLDRSHLLGDTGELAAMVRDPRKPDAREDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0A4</accession>
    <name>A0A317V0A4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome associated DnaJ chaperone Zuotin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_540556</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000050">
        <property type="protein sequence ID" value="PWY66801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461737.1">
        <property type="nucleotide sequence ID" value="XM_025612940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0A4"/>
    <dbReference type="STRING" id="1450535.A0A317V0A4"/>
    <dbReference type="GeneID" id="37115083"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23953">
        <property type="entry name" value="zuotin_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.840">
        <property type="entry name" value="Ribosome-associated complex head domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032003">
        <property type="entry name" value="RAC_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042569">
        <property type="entry name" value="RAC_head_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058871">
        <property type="entry name" value="Zuotin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16717">
        <property type="entry name" value="RAC_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26185">
        <property type="entry name" value="Zuotin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="325"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY66801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="447" mass="50981" checksum="A9F358679C6E82ED" modified="2018-10-10" version="1">MATVQTINVTLPSLPAGWSAEKDFKAVGSVSAATQRNLEPVGPHFLAHARRKRHQRTFSEDERIQAQQNVKSTEDDEDDDISEDEDPMLLAREAKDWKGQDHYQVLGLSKHRWRATPEQIKRAHRKKVLRHHPDKKAALGDRDENDNFFKCIQKATEVLSDPVKRRQFDSVDEAAEVEPPTKKEAAKGNFFKLWRPVFKAEGRFSKIQPVPQLGDENSTQEEVENFYNFWYDFDSWRTFEYLDEDVPDDNENRDQKRHMEKKNANARRKRKTEDTARLRHLVDDCAAGDERIKKFRKAARADKDKKRLEKEAEIKRLAEEKEKARLAEEQAKKDAEEAAKAEREKNKKAKEAAKNATKKNKRVLKGSVKDVNYFGEGGEPSAAQVDSVLGDVDLVISKIDAEELAGLAERLTAAGKDSAAVKTVYVEEVKRLVGAGKVKEGEAKFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0D0</accession>
    <name>A0A317V0D0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitin-binding type-4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_612331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461841.1">
        <property type="nucleotide sequence ID" value="XM_025616666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0D0"/>
    <dbReference type="GeneID" id="37118809"/>
    <dbReference type="OrthoDB" id="5332384at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016244926" description="Chitin-binding type-4 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="22718" checksum="19C49024D54B8BE0" modified="2018-10-10" version="1">MSTKILKGLALAGLVSAAAACSTKSDVEITFYGYPDNDPPSADIAYDCGRGYTAGGTGTHSDPLTFASAPGEFTKCEIIYLPYLRKYLRFEDTCAQCTSDYENGKRHIDIWTGSTTSNGGDAQIDCEDDLTPDDSQTIIIDPSSSLTVNTGKLFSDGSCHTSNTYTDADASSYCSSGSSSSGSGSSSSCEWEGHCAGASCSNENDCSGDLTCKSGKCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2I0</accession>
    <name>A0A317V2I0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_540463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461892.1">
        <property type="nucleotide sequence ID" value="XM_025612919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2I0"/>
    <dbReference type="STRING" id="1450535.A0A317V2I0"/>
    <dbReference type="GeneID" id="37115062"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016275787" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY67248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="30337" checksum="394A685D3BC0BB04" modified="2018-10-10" version="1">MGIRGIAASFILLVASCTTVSAANTCYFPNGNIATENVPCSSDGHSACCGTGDICLSNNLCMDTAEQPYVLSRGACTDPDWESENCPSVCRACCLPRRCSLSVRDKLTYYGLQLIEDVNKSGGSSIINLLYVDGVSTYCCGTPISNGSDVICPYGNSFEVATGKMIVGYAGLANLTTKRNDTASSTNCSSSSTSLPSASSSASSSSSGSSGSSSKDTAIGVGVGVPLGVIASAAIVWGAWERKQRRRLQQIASAGGNSMFEQQQYSVHFMKTPADPAELEVDRMRHELQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2K3</accession>
    <name>A0A317V2K3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_310032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461922.1">
        <property type="nucleotide sequence ID" value="XM_025606814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2K3"/>
    <dbReference type="GeneID" id="37108957"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY67278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="128" mass="13816" checksum="11A50E718F1522D0" modified="2018-10-10" version="1">MDSCNCNCNSETGLTGRGHRLTWLTAGLSSVQLILQILQSHDGRSCGESGISRVESSRVESHPASSGGVVINNQGPKYRTWKSFFYPNKASILQTQPPELVSLPCSVSLCFFLLACWIACLLLASLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5Y6</accession>
    <name>A0A317V5Y6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MAPKKK cascade protein kinase regulator Ste50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_478772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461929.1">
        <property type="nucleotide sequence ID" value="XM_025608710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5Y6"/>
    <dbReference type="STRING" id="1450535.A0A317V5Y6"/>
    <dbReference type="GeneID" id="37110853"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09533">
        <property type="entry name" value="SAM_Ste50-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="67"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="384"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY67580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54060" checksum="4C4F185A00D245D2" modified="2018-10-10" version="1">MSLHTSYHADSDADDEYERSVITSPHLATDSEASPSESEFPSAEHTPTTLANIEDNPRSPRTIITEWTAEECANFVAALGLRQYCGAFIENEIVGEALIALKHDELKEMGIASVGHRLTILKSVYETKVKQDIPIDADHYIPLSADQSMNEGATQEDIARLIQSIRIRDERIVTMESEMRRIAEEYRRLREELLPVFKMAKDKSQPLPPPTSVPVSSSEGYHDGQTLTSPSGITLLDRSGSILSRTFSKRGHTGGTTPKTNSPTHIPPSIHEGRMYSDGGGLDPSTANSSHMTILNGKSQLSPGIPSPTSPGNHYAPQTLASRAYTQSSSNSINHMSHNHHEDTLPPQSRSDRLNPTPTQATRPDIPTRSESRATQEPPSVEIFKSFRVSMDDPCHKVLPAALKKYNINADWKQYALYIVYGDQERCLGLEERPLILFKQLEKEGRKPMFMLRKQVHPIESGMYSGGGSAPNSAGFEGRQAQINLPGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5Y9</accession>
    <name>A0A317V5Y9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YjgF-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_527455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462264.1">
        <property type="nucleotide sequence ID" value="XM_025610387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5Y9"/>
    <dbReference type="STRING" id="1450535.A0A317V5Y9"/>
    <dbReference type="GeneID" id="37112530"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF58">
        <property type="entry name" value="PROTEIN HMF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="127" mass="13638" checksum="DAE4BAEB4CE3A6F5" modified="2018-10-10" version="1">MLLSHITYISPDDHKKLLIQQSQAIKANGTVWLSGQIPADAEGKLINGSVTEKTQANIHNTEAILKEAGSGLDMVAKVVVYVNNASIMPEFASVYNPAFPHKPARSMVEVSKLPAGVDIQLNFIAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6J5</accession>
    <name>A0A317V6J5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_477683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6J5"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="149" mass="17302" checksum="74540465198D3598" modified="2018-10-10" version="1" fragment="single">LCLVHTTTGCGEQGFPSAQPYLSHTPGANPFCCMFLSFPFYYPFPSTFLPFTSRSIFLIFLIFFFFLVSVVWMGCVYLISYCICLVDTGRCGWVCWFMDAALHLECCLVFKQQITIFVCYRTVQPRFYLFKYLMNTDKTSHYEGESYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7H7</accession>
    <name>A0A317V7H7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Acylphosphatase</fullName>
            <ecNumber evidence="1 2">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_540276</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1 2"/>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462102.1">
        <property type="nucleotide sequence ID" value="XM_025612884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7H7"/>
    <dbReference type="GeneID" id="37115027"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268:SF4">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="4">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY68080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="102" mass="11357" checksum="95A2AB8F4FB328C7" modified="2018-10-10" version="1">MASQRIAFKVSGTVQGVGFRDFTQRRAADYDLKGWVKNTHCGRVEGEAQGTEESIQKLLKDINNGPRHAHVVKLEKKEIAPKDGEVEFGFMKTSESGYEGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7N5</accession>
    <name>A0A317V7N5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_579021</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462664.1">
        <property type="nucleotide sequence ID" value="XM_025615242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7N5"/>
    <dbReference type="STRING" id="1450535.A0A317V7N5"/>
    <dbReference type="GeneID" id="37117385"/>
    <dbReference type="OrthoDB" id="4136894at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019716">
        <property type="entry name" value="Ribosomal_mL53"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10780">
        <property type="entry name" value="MRP_L53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY70373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="106" mass="11803" checksum="C68AB2A00F6AA49C" modified="2018-10-10" version="1">MTIPLSTIATFRTTFNPFVRSARPCRLILSLLRNPTTTPASSPGFIDIKVTQLPRHSTQEPELTIGFKNGKELKIEVGKRQMKIGDVIEEIARVGRAIAREEALKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8G0</accession>
    <name>A0A317V8G0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_539809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462636.1">
        <property type="nucleotide sequence ID" value="XM_025612782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8G0"/>
    <dbReference type="GeneID" id="37114925"/>
    <dbReference type="OrthoDB" id="5394455at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY70345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="104" mass="11451" checksum="F10E1D0077A2C0BB" modified="2018-10-10" version="1">MQVAEILSDLTSLRVCDHHDALALVTVNERIPLAADSTQPSTIAAIQASAGTNQDGYENEDLRRAKELVDLHYEIKARHALGTVDEELSSAREEVARVLRELSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V920</accession>
    <name>A0A317V920_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_477044</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462758.1">
        <property type="nucleotide sequence ID" value="XM_025608624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V920"/>
    <dbReference type="GeneID" id="37110767"/>
    <dbReference type="OrthoDB" id="4507588at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36254" checksum="229BF4BF28ED3125" modified="2018-10-10" version="1">MERRRLHYYPGYGSAASTCSANNAFSSKESRIVLAFSALYFLVYCCLSAIAATRFFSSKRRASTFRRWFLFGVSIYSMIISQIIYIVIITLWECEVIDSPTYNLTTISIDWFDYLGYYALYAVILLPICRRLHQQAQNDRLIVVTHSVCLALLGILFIAALALETDIANGIYNSQNYTFYNLVKPERDLRTACYAFEVVAMLMAAASMIKAMMRAPHLRKGTLGSSLAVLIISCLGLPLTRLAGYVESSYWVVKTQSEVAYANRSLEARIFIMYFFYSCAFLSALLVAGFRRLANDSYKWTRTAAMGPVYAPEEHPIRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VB66</accession>
    <name>A0A317VB66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_269195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462608.1">
        <property type="nucleotide sequence ID" value="XM_025606545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VB66"/>
    <dbReference type="GeneID" id="37108688"/>
    <dbReference type="OrthoDB" id="4399046at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="210" mass="24482" checksum="AFDC2D11DAAD6DDE" modified="2018-10-10" version="1">MFSCCDGMEYWVEVNEQGPRLCRKRKTSTRCTLPANVRPLARSETVRPETVRSTALRSTAVHSTAVRYTAARYTAARSTAGRSEANRRPFEEYITWDTPHYRAFLVPESEIVELGKEAWLDRRRKYRELRESCKELMEKRNKDCVPSHYERSAGYRTDVKQTPVRPKDNTPGRPKDTYVRSSYRSNGNQAATASTRRQTWTNDRVTNSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VC31</accession>
    <name>A0A317VC31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_590113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462695.1">
        <property type="nucleotide sequence ID" value="XM_025615993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VC31"/>
    <dbReference type="GeneID" id="37118136"/>
    <dbReference type="OrthoDB" id="5230873at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016432967" evidence="1">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY70801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="185" mass="20154" checksum="3F60BE1E52FDD82B" modified="2018-10-10" version="1">MRTSFAVSVFSALAAVTGVTASPLRSLRDVVKRSPDGNFTLYDYGVASSPIKLFYADGLAYFGTASDWTYGSVVTDITLTFSDGEISTEALTDGVTLADDTLLYIRPNDDAITEVGFTGDDTPSDAVTDKWIWYGAWLMYEDDSGELFDTFYVKETNVTGVWQLYWAPVGVSTTGYTSANVRDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCJ9</accession>
    <name>A0A317VCJ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_610845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462438.1">
        <property type="nucleotide sequence ID" value="XM_025616615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCJ9"/>
    <dbReference type="STRING" id="1450535.A0A317VCJ9"/>
    <dbReference type="GeneID" id="37118758"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY69610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="270" mass="28959" checksum="741D134C48B39B9B" modified="2018-10-10" version="1">MAIFSTNIVGVALIVGKHSGHIAETIKCQEIGREAGFQIADAGAAAVVFADPSGALAEECSKYLKDTVPAKEGQEYQTTSYTIDDKSKESIQAVVTAVIEAYGRLDYVVNTIGISQDPNGGVQNEGMINCCDVEAAAMSRQTDSQYWGKPAKRNIGRGVIVNVTPPNPGALFHDYKLVGMDVTTRTALREGVRCNLVSVDWFENKWCNQDLSSNEQNSIEENLPFKRPADLVEVGGTIAFLVSPAASYLNANCLVLDGGPQKTRNGGPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDI6</accession>
    <name>A0A317VDI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_539614</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462832.1">
        <property type="nucleotide sequence ID" value="XM_025612734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDI6"/>
    <dbReference type="STRING" id="1450535.A0A317VDI6"/>
    <dbReference type="GeneID" id="37114877"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="120"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="210"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY71077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="306" mass="34854" checksum="AFECCD3F8F24726A" modified="2018-10-10" version="1">MHSFRAACRLLSLTAPAPLRSTQAIPSFTSRVTVPLRISQPLLQSRWNSNEVKPQSEPTSTDAPAETPVETPVESESREPTAIRFVKTEEAHSRLTEEERVAKRREQRNRLLSTPPSPKETVFIGNLFYDVTAEDLRRTMEKYGTVEKAIIVFDSRGLSRGYGYVQFDTIETAQRAISAMHLRLYEGRRVTVQFAQNNMNHRRVLQEPSKTLYIGNLPFEMTDRDINELFKDVQNVIDVRVAVDRRTGQPRGFAHAQFISVASAQQGFAVLENKKPYGRTLRLNYSKSTNKSVTEPLVKEIENNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VDQ2</accession>
    <name>A0A317VDQ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_475767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463278.1">
        <property type="nucleotide sequence ID" value="XM_025608576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VDQ2"/>
    <dbReference type="GeneID" id="37110719"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039136">
        <property type="entry name" value="NUFIP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019496">
        <property type="entry name" value="NUFIP1_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309:SF0">
        <property type="entry name" value="FMR1-INTERACTING PROTEIN NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13309">
        <property type="entry name" value="NUCLEAR FRAGILE X MENTAL RETARDATION PROTEIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10453">
        <property type="entry name" value="NUFIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="507"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="507"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="580"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="288"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY72504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="630" mass="68286" checksum="4FFB4D9FE8323370" modified="2018-10-10" version="1">MTPDANRAYPAATPSVGYAHMNYAAYPTQPLSTTPHAIPTTQVAPPTSPNFQHPPNASSFTASQPFTQQAARLPPYQGQPNYGGTYTPSPAQPGPAYPSVMPSHQHVNQPVQTPMMGPPMRWGFEHTGLAGSFAGAQRSPQRGGRPYNGYNAQPPTGDRPTNYTNKRDHSSAFGKPQSVAPRIPAPPPVPSFGNPLPSKPPPPADATRKPKKKKRKHNQLGLTPKTEEHESSEEEDDADEEARLAAGGGGASASLQITYRGKTATLQSQEDIAAWIKERRKRYPTQARVEEKKKAMEEAKKARQEAQRQRDLRKQELKRAQKDGRNRKEHDKQTKEQPADPMDAAAKAKQKADKLRRKLMKEEKRVAKAEADAERARIRAEELQKGSTDANVDKSLATPEAQAQPNGPDPESKSGKPASTAAEGSEINHCDTTPATDIKSDTGKSEETREGDGLSVPSSEISDSSDWTSSSGSDSSSDDSDSDDDSAPEEASSRREGPERLPPPARDSKKKVCRHFARNGRCARGQNCRFLHEAPERASKAKPTEPQGRKGLLQALLERQKGEEDRKVMEAIAWLGENGFLDAPTDLGDASDKTSVTEGAEITRHAEKEQQAAPEATISGQEADAAAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VF16</accession>
    <name>A0A317VF16_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MBOAT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_628057</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462940.1">
        <property type="nucleotide sequence ID" value="XM_025617454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VF16"/>
    <dbReference type="STRING" id="1450535.A0A317VF16"/>
    <dbReference type="GeneID" id="37119597"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY71542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="555" mass="63155" checksum="502478805D93E47E" modified="2018-10-10" version="1">MLPYINLLFEYPAKATGASIDELKLIASFLLSYPLAGLLKRIPDAQPWKKNAFIIAVSLFYVVGVFDLWDGLRTLFYSAAGTYLIAYYIDGSLMPWIGFIFLMGHMSISHIYRQIVNDPQTIDITGAQMVLVMKLSSFCWNVHDGRLPQGQLSDPQKYAAITQFPSILDYTGYVLFFPALFGGPSFEYVDYRRWLDTTLFEIPPGTDPSKVPPTRKKRKIPRSGTPATKKALIGLGWIFAFLQLGSYYNQEAILSGRYMEYSFPRRVWIMHMVGLTARLKYYGVWSLTEGACILSGMGYNGFDPKSGKVFWNRLENIDPWKLETAQNSHGYLGSWNKNTNHWLRNYVYLRVTPRGKKPGFRASMATFATSAFWHGFYPGYYLTFILGSFIQTGAKNFRRYVRPFFLTPDGSKPTPYKRYYDIMSWFTTQVTMSFTVMPFIFLSFSTSIGVWRSVYFYGIVGNILSLAFFASPAKGILIQKLKSRNRPHVTRSTSSDALQQPTLGLPSDAVQAFDEAVQEIRGEIESRRRRGSAVTMPTGEELKAVVENKIGRKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFA7</accession>
    <name>A0A317VFA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_539382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463013.1">
        <property type="nucleotide sequence ID" value="XM_025612697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFA7"/>
    <dbReference type="STRING" id="1450535.A0A317VFA7"/>
    <dbReference type="GeneID" id="37114840"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016432964" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY71777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="29749" checksum="52390A5C6643A84A" modified="2018-10-10" version="1">MGVIDAWLGCFLLMALGGRLVAGTTCYFPDGTEATNYTPCSDDGVSFCCNENSICLSNGLCTSMHQPYVLGRGACTSQSWNETSVCDDVCHGITTAWGTACSLILYSDVNGKALYCPNSIISNGTSSIGCADGVSPIQVATGQPIAGKAYLSKYTLTSSITTTNTTSNSSSSSNDNCANTSSGNTNNSTTGSNSTNDGDKVSRETLAAVGAGVGVPLGLLAMASLGYGYNERRKRVQLQNSPAFMSQMHHTTVYRSNLGPKELSGQIPLHELGEMNRHELAGTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFR7</accession>
    <name>A0A317VFR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_475447</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463451.1">
        <property type="nucleotide sequence ID" value="XM_025608568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFR7"/>
    <dbReference type="STRING" id="1450535.A0A317VFR7"/>
    <dbReference type="GeneID" id="37110711"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="6"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY73186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="421" mass="46499" checksum="4DAE0E1EEF025F4A" modified="2018-10-10" version="1">MAPRKIIIDTDPGIDDILAILLALSAKPEEVEILLISLTFGNIEVKSCLRNVVSMFHILEREMKWRRDQGRPEGYGTLRASPPVVAVGAADPLEDQKMLADYFHGMDGLGGIHASHPHLTPEETWEHLFDPSADPNVVEPVPTGDPAHRSFIPSKRPAHEEILRILRENDPDTVTLVAVGPLTNLALASSAEPETFLRVKEVVVMGGAINQPGNVTPAAEFNAYADAVAAARVYALTSPSPKSTLPPGTSLAQYPPRLSKQLTLRIFPLDITLRHNVTQGQFRKTIKPLLEAGSPLAEWVSAFMAHSFRTLERLHPGHTGDVAELSMHDPVCVWYAMTAEHDGWKPSATSPEDIRIETTGQWTRGLCVVDRRNRHRIEAEEESPTDQGLWLSQSAGNRVWRMDNSPVEDTFGDVLLQKLFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGM4</accession>
    <name>A0A317VGM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_250786</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463111.1">
        <property type="nucleotide sequence ID" value="XM_025606433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGM4"/>
    <dbReference type="STRING" id="1450535.A0A317VGM4"/>
    <dbReference type="GeneID" id="37108576"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052788">
        <property type="entry name" value="RING-type_E3_ligase_ATL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798:SF97">
        <property type="entry name" value="ALCOHOL-SENSITIVE RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="113"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY72158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17951" checksum="23AC0176EC502B26" modified="2018-10-10" version="1">MEESTPQPTPDPGSPKVPDKTLQLQVLLILCLGIYIITAICLLLKSYCIAYGTLDFTSTPAATPDQPSPWDSSQRLKSLNRVAPLKRYETWYSSSLRNERSPLLGDEGESSICAICLDPVHSEDIIHALACKHVFHGRCLESWFLEYHDACPVCWRVFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGR8</accession>
    <name>A0A317VGR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_550424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000037">
        <property type="protein sequence ID" value="PWY71040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462795.1">
        <property type="nucleotide sequence ID" value="XM_025613493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGR8"/>
    <dbReference type="STRING" id="1450535.A0A317VGR8"/>
    <dbReference type="GeneID" id="37115636"/>
    <dbReference type="OrthoDB" id="4510977at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016401805" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY71040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="23202" checksum="ABC6C95EA279CD7A" modified="2018-10-10" version="1">MRLQFATSLALLATASSVVADDVVSMLWPSSADGYDAKLIGTTGGALTTLVINCPATASSTGPITSASAATTSAAVAKRATTASSSDDDDDDDCDIPAEGRTVVAGSSTWSYTYSGTDLAEYAACTYSGTTWLSCALTVSMDGQVSSDNGASSTEIPKVPITVTATVSGTGSSASATGTASGSTASATGKSSSSTQSASGSSSSSASASASTSDSGAMAFATGASQLVAGGAAMMIALAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHF3</accession>
    <name>A0A317VHF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tim17-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_475142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463538.1">
        <property type="nucleotide sequence ID" value="XM_025608548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHF3"/>
    <dbReference type="STRING" id="1450535.A0A317VHF3"/>
    <dbReference type="GeneID" id="37110691"/>
    <dbReference type="OrthoDB" id="5584028at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852:SF1">
        <property type="entry name" value="HIG1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37852">
        <property type="entry name" value="YALI0B21208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY73786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22887" checksum="5344948CC3C9428A" modified="2018-10-10" version="1">MDDQDPSNKYNEHSLSYKIIYWDKFFESDAPPRLGMGIRKRVNYVTLSAFSAGLGVGYAHGSKMLAYRFRAENAHRFPETPQAWFQYHKTKNYTSLIGGIKEGFRMGAKLGTGALLFCLFEETVDYARHDQRDFLSTVTAGLSFSGIYSLLGRHDVYTAARTAKLGLKLSLAYGLMQDALAYAKGNRPAYVDFIMGSRRSKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHG8</accession>
    <name>A0A317VHG8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein DOM34 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_568820</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the Dom34-Hbs1 complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway (PubMed:20890290). In the Dom34-Hbs1 complex, dom34 recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Dom34-Hbs1 complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463566.1">
        <property type="nucleotide sequence ID" value="XM_025614703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHG8"/>
    <dbReference type="STRING" id="1450535.A0A317VHG8"/>
    <dbReference type="GeneID" id="37116846"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000004">
        <property type="entry name" value="Protein DOM34 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000001">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY73814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="403" mass="44394" checksum="16570827F0DF02E0" modified="2018-10-10" version="1">MRLIKNKIEHNGSGTVTLCPEEPEDMWHAYNLIRPNDLLRASAIRRVTTTQETGSTSSARVHLMLEIRVKNLDFDPQSSQLHVSGTIVNETAHTKIGQHHTLDLELNRNFTLEKEVGADGEGVGWDSIAVQMLKDAVDEGGNRRAEAVAVVMQEGLAHICFIGQFQTILKQKVEMSVPRKRHGGGDHDKGMSKFFQVTLDTLLRQLEFNTSSVALTSNEAVRPVLLASPGFVAAGFQKYIQSVASTTTPALKRLLPSIVVVHSASGYLHSLAEVLQSPAVKTILADTKYARETRLMDDFLEQLRKETNKATYGPREVESAVDQGAVGRGGGVLIISNRLFRSQDVAERKRWVSLVDRVRDVEGGEVRVLSSDHESGRRLDGLGGVAALLTFPIVDEDIEEDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHT9</accession>
    <name>A0A317VHT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_578263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463635.1">
        <property type="nucleotide sequence ID" value="XM_025615206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHT9"/>
    <dbReference type="STRING" id="1450535.A0A317VHT9"/>
    <dbReference type="GeneID" id="37117349"/>
    <dbReference type="OrthoDB" id="3594103at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37538:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="50006" checksum="7B966BB4F1C16E88" modified="2018-10-10" version="1">MVVNGSNMSARYAPKPEFDDEVEEYEQPELSPYETRLVIVLMGPSERKYSIPEYYLKQSPVFADILSTYPNFITRTTPCIALPDIDDDITHTIVHYLHTGTYQTLRQGGDWTKTEYRRSVLAYSAASKYELRGLLVLAKKYMQKLDKDLSIFDVLSVARKAFGKIPDYDQWFFSTYVKSRLAAAFDEDEDLFESPRFQYLLGAEPGFVTCLVQAMVAIYEAKLSELKQFPRINGVHDGEGEGMNEDDSGYPASPGRGYNKAVIFIEETVSDRPPSEGPVSEAYPESVPDDTGPMEAFPELTDDVYVPETHAEERYAPAEEPIAEEPFPETQAQDQTHSEEPDNTPAIERWTTWRNWGSKDRDWYREVHESPIPEKPAPETQVEEAVPEYSEIQRTMTEETGTESVPADTGKKLGKKSRKKKMRALFSSAEEPKAEPQAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VIC3</accession>
    <name>A0A317VIC3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_260644</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462978.1">
        <property type="nucleotide sequence ID" value="XM_025606487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VIC3"/>
    <dbReference type="GeneID" id="37108630"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY71580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="71" mass="8311" checksum="A4D114A128132136" modified="2018-10-10" version="1">MRLRSRSRSRSMLKGCEGEGEARLYFPCFIFPISYIFLMIMMIAMTTVVYFPYLSCSGSDFTSYFVRIFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJC1</accession>
    <name>A0A317VJC1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoside hydrolase 131 catalytic N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_578329</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463383.1">
        <property type="nucleotide sequence ID" value="XM_025615210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJC1"/>
    <dbReference type="STRING" id="1450535.A0A317VJC1"/>
    <dbReference type="GeneID" id="37117353"/>
    <dbReference type="OrthoDB" id="120072at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016377522" description="Glycoside hydrolase 131 catalytic N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="16"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 131 catalytic N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY73118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="389" mass="40558" checksum="ABF238EEE614C206" modified="2018-10-10" version="1">MKPLSLLAFPASTLAGSVLWSGIFNSSATVTDFDDWSWSNQIEPWQWYIHGSDNTSEYLGLSSSYKNPAASDAQGLRTTIDGTSFWEGQTMERTELIPQTTSDLGSGHLYYHFSLSTSSTNAPNATYEHQIAFFESHFTELQYGTVSGSSGSDNTLRWNAGGTTHWSVTLVPGNWYNFAYDIDFTNQKVGLWASNGSEALTEVVSPVSASASSNSADWHVGVLRLAGSGTNDDNAEDWFWSGVYVEEDSLTKEIGDGSSSTSSASSIAEATTPSTSTSSSASAVETTSAAETTTSAEVTPTEVVAVQTSSTSTSTAAPTSSTSTAAPIIATPTATSTPSSSTAASAAGSASVSSLPVPTTAVQILDDVKALLAALLTRGGGVHARDFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJP8</accession>
    <name>A0A317VJP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Carboxyvinyl-carboxyphosphonate phosphorylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_248496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463073.1">
        <property type="nucleotide sequence ID" value="XM_025606423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJP8"/>
    <dbReference type="STRING" id="1450535.A0A317VJP8"/>
    <dbReference type="GeneID" id="37108566"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF13">
        <property type="entry name" value="CARBOXYVINYL-CARBOXYPHOSPHONATE PHOSPHORYLMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY72120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="346" mass="37890" checksum="1D48167A13B4BE2B" modified="2018-10-10" version="1">MASQNPTPYPFQFDTSEHIETHHNGSSEDTTIILTNVCGRIPSAQASRLRTMWLEAHRDPTKIIAHPCGYDALSSRLIEEAGFPMIFVSGFAVAASHGLPDTGYIAMGEMSSRIQEIVRVTSVPIMVDGDTGYGSPMNVRRTVECFAAAGAAGVMIEDQTWPKRCGHTKGKSVVSRGEAYARVQAAVDARNQGQDIFILARTDSLIHGWDEAMTRAKEFKRIGADGVFVEALPDREAMRNCIKELDVPMLANIIEGGKSENLSAKELAELGFAAVAYPWTLVAARLQSIREALDGLKRSFMTGAPPMVLGYSEVCEGVGFNKYWDMEPRYEYDDEGLVSPPSENMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRN2</accession>
    <name>A0A317VRN2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Purine-cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_538723</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463753.1">
        <property type="nucleotide sequence ID" value="XM_025612550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRN2"/>
    <dbReference type="STRING" id="1450535.A0A317VRN2"/>
    <dbReference type="GeneID" id="37114693"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11484">
        <property type="entry name" value="SLC-NCS1sbd_CobB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF1">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY74560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="511" mass="55273" checksum="BACCE5129EB5020F" modified="2018-10-10" version="1">MFGGADTDLEKAPQVGKAPMDDTSDGAVPGESFMYGNSLYAKLQRLAGKLNIEQRGVERVPDNERNDTSYFNISSMWLAANMVVSSFAIGVLGYGTFGLGFVDAILVCLFFNLLGVLTVCWFSCFGPAFGLRQMVLTRFWFGWYPTKFIAVLNVLSCLGWSAANSIVGAQLLNAVNSDVPGFAGILIIAICTLFVTFAGYKVVHLYEFYSWIPTFIVFMIVLGMFAHSGDFQNIPMGVGKAEVGSVLAYGATVYGFATGWTSYAADYTVYQPSDRSRLKIFFAAWSGLIVPLLFTQFLGIAVMTATSINGGDNKYAIGYNQSGNGGLLGAVLDPLGGFGKFCLVILSLSIIANNCPNIYSVSLTLQVLSRYSQRVPRFVWVFLASCVSVAVAIPGYSHFEEVLENLMDFIAYWLAIYSGVALADHIVIRRGFSGYRPETYDKPDKLPYGIAACVAFAFGVAGMVVGMSETWYTGPIAKSAGGGDVGFELGLAFSAVVYAVLRPIELKMLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRW8</accession>
    <name>A0A317VRW8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_605245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464038.1">
        <property type="nucleotide sequence ID" value="XM_025616475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRW8"/>
    <dbReference type="GeneID" id="37118618"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="50"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY76041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="550" mass="59245" checksum="6F5B82007CEF9E1A" modified="2018-10-10" version="1">MADTQRSIRVDDGFEDPDAIELVVEAESSPTTVVEETVSSSDGSDQEPSTARFVIILLGLWVSNSTMLATIIEDICDDFDAFASYSWIATTYPIGLSISQPFSGQLTNLVGRRYGLVICLSVLVIGQLLCGLAPRLSVFLLGRIIQGLGAGCIGTITAFVETDLVSMRKRALIEGIGNITYGITLALGGVYGGGVANAIGWKWAFRIQVPFIVLDIAMVAFFLNIPQGKSRPVKRPVDYIGMASLLVIIILFQFGMNSAGSVFAWNSSAVLATLIIAGIGFITFIYWELYHATNPHIPVRALLQRTVAASQLSSFFSNFANTSIMYYVPVYLEVLGHSPGQSGLRFIPLALCFALGSFAAGFFVKATSKYYFINYPVQACSVLGAAMLCTMTESTPSWAPFIYLGIYGAGSGGAYVTRLMGLLTSTDKQHLLVVQSCSFTVRNTGTTIGQTIAATIFQNLSVESLQSLFRGQPGLADRISRNYNSLDLLSGVEKQAAIHIYLRAARGVFFLSMAASVAAAVLTFGMQNNELVDDPEEKKEKGEGKSGELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VS89</accession>
    <name>A0A317VS89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_473141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464380.1">
        <property type="nucleotide sequence ID" value="XM_025608465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VS89"/>
    <dbReference type="GeneID" id="37110608"/>
    <dbReference type="OrthoDB" id="4508393at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY77193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="52" mass="5588" checksum="C3BC39C7E097523E" modified="2018-10-10" version="1" fragment="single">HGCSCGASCQCPAGQCQCPVRLRPSPGLLLAQLTLRLYDTEINDLSKEQELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VU02</accession>
    <name>A0A317VU02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_549216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464245.1">
        <property type="nucleotide sequence ID" value="XM_025613434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VU02"/>
    <dbReference type="GeneID" id="37115577"/>
    <dbReference type="OrthoDB" id="4221933at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="263" mass="31026" checksum="73BE4E19A2702EC1" modified="2018-10-10" version="1">MEAWQRNIRRIHQVGESLDLDPTKYDTIVDFIALIQAVREGLAYIDEDSYIPDSQINLLFLTKLKECPEWCDWASAMLRDRRMNTPNPADQITFQELTDLAVEHERIRKRRGRPVWSDNGTSRLDVTPSSRSPGDSHAVTQDEINAFVVRQMNRDERLRNRSGSVRGHTKRPSQEEINDYVIEQMRREQEQSTRDRSYSQPVQRPVRMHCTFCGDRHHQLSNCWRRWRVAVEAPHGDYLPKRVEYRTEIPGQPPMYRSGFTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VW20</accession>
    <name>A0A317VW20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="16">HMG-CoA reductase</shortName>
            <ecNumber evidence="16">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_183222</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">HMG-CoA reductase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA). In this module, the cytosolic acetyl-CoA acetyltransferase catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthase then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="16">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="16"/>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464895.1">
        <property type="nucleotide sequence ID" value="XM_025605989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VW20"/>
    <dbReference type="STRING" id="1450535.A0A317VW20"/>
    <dbReference type="GeneID" id="37108132"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.420:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.770.10:FF:000001">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025583">
        <property type="entry name" value="HMG-CoA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF24">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13323">
        <property type="entry name" value="HPIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0521">NADP</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="18">
        <location>
            <begin position="242"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY78586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1131" mass="121948" checksum="CDB75FA3611CF42F" modified="2018-10-10" version="1">MAATLIPRKFRPADVDDDAEPGWFRRQVTSGLQFVSRRACLHPIHTIVVFALLASTTYVGLLEGSLFDSFRNPRNVAGQVDVDTLLQGSRHLRLGESTSWKWQVEDVLTAEDYDAAQHMALATFIFPDSMSKSASTAPLADGVPIPANTSAQRVPHTPNLFSPFSHDSSLVFTLPFEQVSQFLKAVQEIPEPSVDEDEGEQKKWIMRAARGPAYGSSGALKLWLADAWGSFVDLVKHAETIDIVIMTLGYLSMHLSFVSLFFSMRRLGSNFWLATTVLFSGCFAFLFGLLVTTKLGVPINMLLLSEGLPFLVVTIGFEKPIILTRAVLSASVDRRQGSRAGKTGAQTTPSTPLSIQDSIQTAIKKQGFEIVRDYCIEIAILVAGAASGVQGGLRQFCFLAAWILFFDCLLLFTFYTTILCIKLEITRIKRHVALRKALEEDGITHRVAENVASNNDWPLAGSENDGTSETSIFGKKIKSSNVRRFKILMVGGFILINVVNLSAIPFRKSTGIPLLSRVSNVLAPTPIDPFRVAENGLDSIYVSAKSQMMETIVTVIPPIKYKLEYPSVHYAAFGESQSFDIEYSDQFLDAVGGRVIESLLKSIEDPIISKWIIAALTLSIVLNGYLFNAARWSIKEPEAAAPKVEPPTPKVYPKIDLNNQEGPKRTSEECELYLKEKRASYLSDEELVELSLRGKIPGYALEKTMENDELMSRVDAFTRAVKIRRAVVARTAATSEFTNSLENSKLPYKDYNYTLVHGACCENVIGYLPLPLGVAGPITIDGQSYFIPMATTEGVLVASTSRGAKAINAGGGAVTVLTGDGMTRGPCVGFPTLARAAAAKVWLDSEEGQSVMMAAFNSTSRFARLQHMKTALAGTYLYIRFKTTTGDAMGMNMISKGVEKALHVMATECGFDDMATISVSGNFCTDKKSAAVNWIDGRGKSVVAEAIIPGEVVRSVLKSDVDALVELNTSKNLIGSAMAGSLGGFNAHASNIVTAVFLATGQDPAQNVESSSCITTMRNLNGNLQIAVSMPSIEVGTIGGGTILEGQSAMLELLGVRGSHPTTPGNNARQLARIVGAAVLAGELSLCSALAAGHLVRAHMAHNRSAAPTRSATPVSAAVGAARGLAMTSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWE4</accession>
    <name>A0A317VWE4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_498610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464415.1">
        <property type="nucleotide sequence ID" value="XM_025609352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWE4"/>
    <dbReference type="STRING" id="1450535.A0A317VWE4"/>
    <dbReference type="GeneID" id="37111495"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000009">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="19"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY77228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="36356" checksum="8FCE83A74DFEF98B" modified="2018-10-10" version="1">MSLVSGPSRAVGTPSSLNLSVERHVEYIKNLDSRRDELEYWLTEHLRLNGVYWGLTALHLLGRPDALPREDTINFVLSCQRADGGFGAAPGHDAHMLYTVSAVQILVTLDAVDELDKRGLGGKEKIGSFIAGLQDKDTGAFMGDEWGERDTRFLYGAFNALSLLGLLDTVDVPKAVAYVQQCENLDGGYGIQPGAESHAGQIFTCVGALAIAGRLDLVDRDRLGGWLSERQVDNGGLNGRPEKLPDACYSWWVGASLAMIDRLHWIDSGKLAAFILRCQDSEAGGIGDRPGSMVDVFHTHFAIAGLSLLRFDGVQEVDPVYCLPKAIILNCRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4C7</accession>
    <name>A0A317W4C7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_558275</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465477.1">
        <property type="nucleotide sequence ID" value="XM_025613998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4C7"/>
    <dbReference type="GeneID" id="37116141"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="256"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="56"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY80875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="471" mass="50927" checksum="9E8107DD77B4887A" modified="2018-10-10" version="1">MDITDTGDSTETVVDTKDTLSFSDLEKLSEHHTPPANSAPADTVITYPEGGRDAWLVVLGAWCGLTASLGIYNTVGVFEAVVSNIVLPNDSPSTLGWIFSVYAFVNWVCGVQIGPTFDAMGPRALIIAGTICTLGGIFALSVCTEYYQIFLSFSILTGIGSSLLLTPSMGCVAHWFMERRGLASGIAFIGGGFGGVLFPLMIHSLLPQVGWGWSIRILAFILLVLCIISVAFCRSRVPPRKGTETTWRDTLPDYKIFLDGTGAMALTTAGVLLTDLAYFIPITYVPSYYIDRQHLAQNEALSGSSAFAYQLLAILNAASCVGRYVAGDLADRFGRYNTMIVSLFFCTVSVLCFWLPDILIPGLDGAALLVVFVILFGFFSGSNVSLTPICLGQLCETQEYGRYYASCFTVVAFGVLASLPIGGGLLDAATATGKERYWGTALFAGLSYVGAFLSFLWVRIKIKGWNWKMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4J6</accession>
    <name>A0A317W4J6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_558353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465567.1">
        <property type="nucleotide sequence ID" value="XM_025614004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4J6"/>
    <dbReference type="STRING" id="1450535.A0A317W4J6"/>
    <dbReference type="GeneID" id="37116147"/>
    <dbReference type="OrthoDB" id="4479239at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35251" checksum="36B5E51274D50FEF" modified="2018-10-10" version="1">MNGVASPGGPLHGPGSADSILQDHNRRHPSNRGPVVHFVKPAYDRETHSRCGSEEPSKQPEFHDLVVGEVCKVINKSHLDREPASTCYLDRLPVNVRLRIFGFLFPHDRSVLEVENFPPTEATNLAILRTSHQIYHEASIALFHSLAYRRVFLKNYGASTAYLLRRFPRELESCHWKWLGSVCYNNKLDIRRAFGSIVLSLGDRSHELAVHRRWNFSIFITTLRMDVPLRVHDLTIIATDNWKMPGFDETHLTQDLFSGAFEILGRMMFKGFTRMERKRLVTLILAKRDPRAQVMRRSDEVEVQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W6V4</accession>
    <name>A0A317W6V4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_536966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465340.1">
        <property type="nucleotide sequence ID" value="XM_025612160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W6V4"/>
    <dbReference type="GeneID" id="37114303"/>
    <dbReference type="OrthoDB" id="10467917at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016240726" evidence="1">
        <location>
            <begin position="25"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="99" mass="11497" checksum="96079CFA4A286099" modified="2018-10-10" version="1">MACIIVDCLLLLLLLSVYLGYLAGFAACNPRCGCNFDFDFDFGWVDLSERERLIERRFVSIPCTSNDDLLNEALNRDEVRLTGWFELRAICRGTWWLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W9F2</accession>
    <name>A0A317W9F2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_576437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466029.1">
        <property type="nucleotide sequence ID" value="XM_025615137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W9F2"/>
    <dbReference type="STRING" id="1450535.A0A317W9F2"/>
    <dbReference type="GeneID" id="37117280"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="71"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY83244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="512" mass="57038" checksum="C980DBA84C21E718" modified="2018-10-10" version="1">MTADQKKPGLESHVPHDDILKQGELDVLGRPSGQGEDVAVRFLAQLDPAIMAAPIADTEARRVLWKIDLIMIPLIMVTVVLAAVDKVIISNAAIYGMETDTHLTGNQYSWVGSIFYFGYLAFEYPAALLIQRLPVAKLYAGMVFAWAVLMLCTAATHNFAGLATVRFLMGMLEASVFPISSILTVMWWKTSEQPIRVAFWFNQLSSVFSGVVSYGIGHTHTALHPWRLLFLVLGAFSILWSIILYVFLPDSPVQCWYFSDREKFVCLERVKDNNTGMEDKTIKWYQVRECLLDPKTWLLALFSLAQNIPNGGLVTFSALIVTGLGYSSLITTVLGIPTGVLATIWQLLLSFLASRIPNSRCVIIAVSNLVPMACAILMWKLPRSNKHGLLASYYVFYTYWAPYVLSTSLPMANTSGHSKKLTLNAIFFLAYCVGNIIGPQVFRSTDAPTYSHGYEGLLACLVVAIVAISAYGFLCRWENRRRDATDHVVPVSEDAAFSDLTDKEKPSFRYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WA15</accession>
    <name>A0A317WA15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein, Mpv17/PMP22 family</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_152547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465522.1">
        <property type="nucleotide sequence ID" value="XM_025605810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WA15"/>
    <dbReference type="STRING" id="1450535.A0A317WA15"/>
    <dbReference type="GeneID" id="37107953"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY80920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20428" checksum="0CD5465307662F4B" modified="2018-10-10" version="1">MVFPPIARATLQAALINAGSNILAQAIGAYRDERPFELDSQALFQFTTCAFILSPLTFLWLEGLESKFPGHDDTSAPSPKSEKVKHKPQLNFTNTVAKIVIDQIVGGAWNTAAFIMTMGFLRGQDWDTILQQTQKDFWPIMVAGFKLWPFVSVLNFTVVPTDKRLLVGSLFGVLWAVYLSLMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WA59</accession>
    <name>A0A317WA59_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioesterase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_519656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465884.1">
        <property type="nucleotide sequence ID" value="XM_025610081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WA59"/>
    <dbReference type="STRING" id="1450535.A0A317WA59"/>
    <dbReference type="GeneID" id="37112224"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF7">
        <property type="entry name" value="THIOESTERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G10800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="205"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY83099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="310" mass="33312" checksum="F51FF57213D5445D" modified="2018-10-10" version="1">MPSVPTMLGSTTITRRLVLAGPLSSLPITAPTRFSTLSRGISLAPRLSRKTYSTASADAASPPSQTPQPRSRFRRFVGFTTIAVVAFTAGLVYQTSKTVSRMMSVNLTTDEETLSAFVPHDDFSKEVDEYIRTHPVAVSLRENPAFTESRPHMKIPEHLRARTLTGGTLSGPDKIVAPPLVFCEDGGKSLVSLFYLGPSLCGHPGIVHGGLLATLLDEAMGRCCFPALPNKVGVTANLSLDYRKPAMAGNYAVLRAETVKVEGRKAWVEGRIETLPEEGKEPVVLVEAKALFIEPKQAAVGSADPLTKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WCW3</accession>
    <name>A0A317WCW3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Ubiquitin-like protein ATG12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_547410</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Forms a conjugate with ATG5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Preautophagosomal structure membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATG12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466223.1">
        <property type="nucleotide sequence ID" value="XM_025613331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WCW3"/>
    <dbReference type="STRING" id="1450535.A0A317WCW3"/>
    <dbReference type="GeneID" id="37115474"/>
    <dbReference type="OrthoDB" id="10003551at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034274">
        <property type="term" value="C:Atg12-Atg5-Atg16 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01612">
        <property type="entry name" value="Ubl_ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000148">
        <property type="entry name" value="Ubiquitin-like protein ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007242">
        <property type="entry name" value="Atg12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385">
        <property type="entry name" value="AUTOPHAGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13385:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN ATG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04110">
        <property type="entry name" value="APG12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 12" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <keyword evidence="7 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY83755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="219" mass="23635" checksum="8C41929C92C684D7" modified="2018-10-10" version="1">MEPSSSQGPSAQNSPKPDQTSLTHRPANRKQSSDSASNTQNAPIPDDKQGADLPMTMSASVVLTSLPRDAHQALADAEAVDTGKGKCNSGVIMLPSSSYVALELSRFYLVLGQSSRLLTSCDLSRRANTNVVAVTVRFQPLPSAPILKNRVFKISASQKFETVVKFLRKKLDCKESDSVFCYVNSVFAPGLDEGVGGLWRCFKTDEQLIVAYSMTPAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE27</accession>
    <name>A0A317WE27_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_625187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466589.1">
        <property type="nucleotide sequence ID" value="XM_025617262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE27"/>
    <dbReference type="STRING" id="1450535.A0A317WE27"/>
    <dbReference type="GeneID" id="37119405"/>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="100" mass="9585" checksum="2F02771E8CE636BB" modified="2018-10-10" version="1">MSSGNDNNNNLERDKVLAPLANLIGGLGDTLGKTVGGLGDTLGNTVGGLGQTVGGATQGLGTTVGGATEGLGNTTRGVGQSTGDILSSINGDRSGGDSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE66</accession>
    <name>A0A317WE66_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pex19 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_105037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466504.1">
        <property type="nucleotide sequence ID" value="XM_025605478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE66"/>
    <dbReference type="STRING" id="1450535.A0A317WE66"/>
    <dbReference type="GeneID" id="37107621"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY84579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="325" mass="34562" checksum="3AC98A0274EF2203" modified="2018-10-10" version="1">MMTMTTNPTLMNWTVLDDFKPKPTPAPAQPDAAQAPSADDFDEEAFLRQLEQDMANMMGGASNDPTGSSAAQADPEFLDQDAETFAKYLEESGVTPSDFLKQLVGDVMMKGEDGDDSTTAATAGSSSSAAPPPAAAAAAAATPAGGNNAAPETFNDTIQRTIERMKESGDKATAAASEDDVSDDLVAQLIKAIEAGAGDGDEGDLTKMFMGMMEQLSNKEILYEPMKELDTKFGPWIAENKGKGKVSDEDMARYEKQAGVVALIVTKFEEKGYSDEDPKCREYVWEKMQEMQAAGNPPDELISAPWMEDLKGPGGAGGAPECPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFJ7</accession>
    <name>A0A317WFJ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional fatty acid transporter and acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_110834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466640.1">
        <property type="nucleotide sequence ID" value="XM_025605507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFJ7"/>
    <dbReference type="STRING" id="1450535.A0A317WFJ7"/>
    <dbReference type="GeneID" id="37107650"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000055">
        <property type="entry name" value="Bifunctional fatty acid transporter/acyl-CoA synthetase (FAT1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF20">
        <property type="entry name" value="FATTY ACID TRANSPORTER_ACYL-COA SYNTHETASE (FAT1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G11360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="73"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY84715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="636" mass="70395" checksum="287F69F0650EC85F" modified="2018-10-10" version="1">MEYLSEISGPSIAIASALSAAAGAYINAKFSVSSDLASLYNERSWTNRLGQRIAQLGDTTTIYKMLERVVEIEGHGSAEALWFEHRTWTYTQLKDLVDRFAALLHTKDIHPGDYVGVFTTNSPEMVVAIYALSKLGAIAALINTNLRDDTFIHCLRVSGSKYIISTPDISQFVCSDLPHSALNLSAFDGVSAGTTAIITLTNLQQQSLSGLTAAKRSIGDLSALIYTSGTTGKPKACAIRNMMALITSNPHTIDVNNRSKYYPLRTYSPLPLFHGTAYFTGICYSVGNAGTLCLRRKFSASQFWKDVHDSRATRILYIGELCRYLLSTPPSPYDRDHACIVASGNGLRGEIWERFRERFGVPEIREFYRSTEGVAKFDNWGVGAWGAGKVGFSGPIKRLLEDDTYIVRYDTETEAPYRDPKTGFCIQAKLGEEGEAIGRVKSRGLLTEYLHNKDATETKLLRNVFKDGDLFQRTGDLVVRDHDGWVRFQDRVGDTFRWKGENVSAGEIRDHICRLPSIHDAVVYGVKLNGYDGQAGAAGITLEDASPATEESVMVSLYSELKKKGVPSYAFPRLVRLTDKVETGVTFKQAKGALTKKGWDPRTDWGGDKLYWLNGTAYQKLDGQSWMSIESGQAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WFU6</accession>
    <name>A0A317WFU6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_547541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466366.1">
        <property type="nucleotide sequence ID" value="XM_025613338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WFU6"/>
    <dbReference type="GeneID" id="37115481"/>
    <dbReference type="OrthoDB" id="5368615at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="160" mass="17702" checksum="F66CD761327D0877" modified="2018-10-10" version="1">MNKVGFISFSDDQTKKVIGTRNLNSCTAVMLASTKGAILAHISPLPGPTNDPDAGEKHVREKMTEFVDLYLFKKDIRLGPEMKQSGIVCGIYLGQIAVPDQQRLIESILQENLEDKPRPKVIPYQINVGGHNQAAGGTVFIDGRHPLPKVYVEDKDQGWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WG63</accession>
    <name>A0A317WG63_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_120351</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465955.1">
        <property type="nucleotide sequence ID" value="XM_025605572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WG63"/>
    <dbReference type="GeneID" id="37107715"/>
    <dbReference type="OrthoDB" id="4504024at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016264867" evidence="2">
        <location>
            <begin position="27"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY83170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="186" mass="20459" checksum="3327B71F420B92F2" modified="2018-10-10" version="1">MLSLTKASSVACVLLACLTFSSIVQAYPVSTSDKETLSRSLDSRSPDPRMIPDSENRDLVNSLFNSLGFSALANLNHWKSDNEPDVIDDSNVPTRTETTKDNTVDDNGDIHTDNSREDKTDSDDDKDSDDSKDKEDDKDSSDKDSKNDTQLPNPATDPAGFVTALMQQIQHTFNEALDSSDEHTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKT5</accession>
    <name>A0A317WKT5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytokinesis regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_76929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466912.1">
        <property type="nucleotide sequence ID" value="XM_025617660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKT5"/>
    <dbReference type="STRING" id="1450535.A0A317WKT5"/>
    <dbReference type="GeneID" id="37119803"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="519"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY86321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="989" mass="107941" checksum="920D05CB1B187BB7" modified="2018-10-10" version="1">MAPLTLEVRHSEEETIECWDDDDDLQCYEDIQLRAASTATSVTTSSIRRSGHRDSISSRRSARSDLDSNAGGDEDWQVQLLDNDELITEEAIASAKNAGIPLPTNVPRSALIGGTIKRLGHRKQKDIVDDWSDDVEFPGPGSSLELKRSLDTSFPEALRQVSSAAVSPIKPSAASFWNSEVSTRLQSALAITSASQPGGGMSDTQDVPTIRVAGSRSPKRASLINSFTPSSDLDSTDNFEEDFELPADDDILLRLSPRKANVGNTSPSPEDFDIDWSEGSIGVRFGGTARDHPSNPSSSVSVVSPSSSSCLTIESEDEGLEGLVIPEGPLDLEASLKKRKVPSSKDVVQLELTSVDRVPLGADDFFSGLEIESGEVFDPRRLSINPNVKCKMEIPRSPARHSTTTITFMNTAVSPKTRIPRLSGHDRPHSTHLETVSESGAPLSRFRTSQRRAGGHSSQSSVSSLPSGSSSSSQIQLTPSRRLVGPGISNDAFFGERVASGRQLLRTKRSMPSLRNMNQAVSNSQSPPIHQDGSCLPNYHARPKTPVDRIGNDAKTFVRKHQAPFIPAGASEKQSHHASVKSHRHNRRSNSEGPGELLSTEGSGTRLSRSTRNDSMGRSPNESSPENLVAASKKTLTRPTRRRNFGDGSELALFDDLPTSSSAEKRFVKHPSGRGVPRTLRSKLSHGQSNTTKTDVTIEQATPGFTIRSNNVTPSFARDTNASRNAREQRIASMTSALKSRDHHPLAPLGLNWKTTNVSRVPSSSATIRSKKGKAAPMPGCKPQLIKPMGTGVQEAKYLNGMRYNPTSFCWEGNENLVQDFNSVSPKSPKPTPALITNIGAMQNVQVVGGMVFDPQRMCWLKLAPLQPGKDGLVAIQDEDDVFAGLGDLKETANVLSGRMSGAYDELGLAASSDDRSYEDSSDEWPITEEFDVGPEFIRRQRAEEEKWRRKVDKWTTHDRGKFGDGWRWAIRDLVRFNSTLRTQNLDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL64</accession>
    <name>A0A317WL64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_535611</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467042.1">
        <property type="nucleotide sequence ID" value="XM_025611829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL64"/>
    <dbReference type="STRING" id="1450535.A0A317WL64"/>
    <dbReference type="GeneID" id="37113972"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000231">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000215">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="11">
        <location>
            <begin position="63"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="218"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY86451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1122" mass="129772" checksum="343E3CB9ADC6E793" modified="2018-10-10" version="1">MDNVPDSEMLVDEYEQYHNDRTDEVVVSRSGSEDLEPEPLADDHAAMMARILPKDPDLETEDETYHTWHIQDWRKLKKKEHGPVFQCAGFPWRVLFFPYGNHVEHASFYLEHAWENEPPANWYACVQFALVLWNVNDPSMYISHVATHRFNSDEGDWGFTRFCELRRLFSMPWEGRGVPLVQNEEARVTAYVRVVKDPTGVLWHSFQNYDSKKETGMVGLKNQGATCYLNSLLQSLYFTNSFRKAVYEIPTEAEASRDNSAWTLQRLFYNLQTNENSVSTTELTASFGWESRQIFEQQDVQELSRKLMERMEEKMKGTPAEKALPELFVGKTKTYISCINVDYESSRVEDFWDIQLNVRGNKTLDDSFKDYIQVETLEGENKYDAGQPYGLQDAKKGVIFESFPPVLHLHLKRFEYDIHRDAMMKINDRHAFPMEFDATPYLSNDADKSEPWIYQLHGVLVHSGDLNAGHYYAFLKPTKDGFWYRFDDDRVTRATDKEVLEENYGGEYELANGAAGVRQPYTRGLSTKRSMNAYMLVYIRKTRLDDVLLPITKDEVPSHIEQRLVEERVELARRKKEREEAHLYINVGVLSEESFRSHHGFDLTSTELPASDPAVPKQYRILRAQTVREFAHQLAEEEGVDHERVRFWVMVNRQNKTTRPDQVIKDQDMTVEEAYNRYGTKGNPFKVWMEVGQPSADGTVSWPDSNSVLVFLKHFDAPSQIISGVGAVYVRKTQKVADLAPAILEKMGWPAGTEFMLYEEIKHNMIDVMKPKQTFQQSEIQDGDIITFQRTIKDSELPASALYTDARQYYDYLLNRINVTFAPIKADEGDEFTLTLSRKMTYDQFSKKVGEHLNVESTHLRFAPVLASTGKPKSFIKRNPNQANQTLYHITGGQPSAYAYSMHRQDALYYEVLETSLSDFESKSCLKVTWLPEGITKEQVVEVLVPRDGTIADLIAGLQKKASLDDETVREIRVYESHGGKIYRDFQEGSKITGINEFVSLYAERVPEDEVNMQGGERTINAFNFDREVNRPHGVPFKFVMKPGEIFKQTKERLSKRTGIKGKQFEKIKFAVVSRNMYSNPRYVEDDDILSDIIGDSDDLLGLEHVNKNRNFWSRSESFFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN89</accession>
    <name>A0A317WN89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_574909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467586.1">
        <property type="nucleotide sequence ID" value="XM_025615051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN89"/>
    <dbReference type="STRING" id="1450535.A0A317WN89"/>
    <dbReference type="GeneID" id="37117194"/>
    <dbReference type="OrthoDB" id="3508621at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="308" mass="35085" checksum="7BAC157B24D566DF" modified="2018-10-10" version="1">MSEQLPVNPSKWDVAARLEKVENKTIHNIDLTSASTIQLEQYLMLRVARIPHDTEFRPNVAISPIAHRTRGQLKRVEEGVRKLTFETPTKPPSTPVLKPELEHDEVTPETPPEKRSYGPQELLDLNFPRTKDEQIVNTALIDFLNAFTIHMNVQSHWTLYRKPFVANFRSASFEARTDGCLEDGGPKTFAIVEVKPMVRFKQSNRISMQEAAEIVAWIKCEPDPDDFTSGCGLRILISQDRHEIYLTFAEYDANYIRYLNNTLGKDEKPGFLTLHVFGPWDTTRAGDVKQLGSILLAIALRAQEDART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNA4</accession>
    <name>A0A317WNA4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MED9</name>
        <name evidence="10" type="ORF">BO94DRAFT_58983</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNA4"/>
    <dbReference type="STRING" id="1450535.A0A317WNA4"/>
    <dbReference type="OrthoDB" id="5414694at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011425">
        <property type="entry name" value="Med9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07544">
        <property type="entry name" value="Med9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="56"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY87934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="208" mass="21405" checksum="DF98AA2025F8C1A9" modified="2018-10-10" version="1">MASRSATPLPKPSAAPETPMVKDAPAAPQVVPFPSPQTFDIVPPLHGLLLRLLSPPTNAAGVSNGVRSADDPNGAVAPTSASGQSQSQPHSSAIAGAENNNNTVVLATVPSAGPGPVPAAAEIAALGSNAPPPLEIKDLPTEASSIKIRIQKAYAVVDSLPDVDRSVADQEEEIKELENRIAKLNSVISDFGKRARPESARKPKFQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPL2</accession>
    <name>A0A317WPL2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GNAT family acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_516321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467748.1">
        <property type="nucleotide sequence ID" value="XM_025609958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPL2"/>
    <dbReference type="STRING" id="1450535.A0A317WPL2"/>
    <dbReference type="GeneID" id="37112101"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF5">
        <property type="entry name" value="HYPOTHETICAL ACETYLTRANSFERASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="142"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="265" mass="30632" checksum="04993111946D1DAA" modified="2018-10-10" version="1">MTMTESDFEVKEIHTKEEYRRLVDVLWTANSHPYIAVFTAVHPVSGHTAEDRVKDKDYDCEIRWAAHQKNPASHFIYVIDKKSGRVAGGCEWLIFRKNPFPNGPQPIPCTWYPEGSERAEYASQMLSQAFFPRQCWLQRPHAGVNAMGVHPDFRRKGVGRLLMDWGHERIDPLGYESFIEGSPTGRFLYEECGYKRVVCLHIDFAKKNPSDEWNRLVHECVPPPILLLWRPPRGVWDERVPAGPWAVTESTWGENKSVEEVVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPT9</accession>
    <name>A0A317WPT9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_546496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467490.1">
        <property type="nucleotide sequence ID" value="XM_025613299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WPT9"/>
    <dbReference type="STRING" id="1450535.A0A317WPT9"/>
    <dbReference type="GeneID" id="37115442"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="672"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="706" mass="81039" checksum="0D19D759416BC228" modified="2018-10-10" version="1">MERSPTKEELLALLQEATSRAEQERSRAEEERSRAKQERNCAEQERNRAEQAETHIQNLTFAEYLRGTHDLISKPLAIQTNLALTTKGPITSPTGRICPEYLEPFDFREMYQDLFDEIYQIFQSPTPKRLFPPLIVLKDRGQRACDRVLASEDDLMKHQQDEVETPVKEIIDRLREIAPDRFPLGEGIMIENHSNTIIEDPETMKSARPTTDRHCVYHRTNDVRSLLYMIQYKAGHKLTDAFLRAGLRPMNMLEEVVQQIKISTDPDEKLRYQATYLSCAALTQHFQDMIKAGCEWGCVSNGHMKVILRIPEDRPETLQYSLLEPSRDAEPNPDDGLGFRYPYTAVGCMLGLTIIASRSMQRGQAWRNAATKTLSRWEVDFEHVLRSIPESERKASPPGSAYRGPKYPINPRSPYLTRQRRLILDGAPSLESNRSPSPDSSDNDTRRKHILSSPIEDRGKRQRKAPGQTFNYMFCTQSCLHGLSSQSEFDDNCPNVHLHQKHSSDHRHPLSRSTLVECIRHQLDRDIDSCYPLGQEGLHGSIFLISLQSYGYTLIGKGTEYLSTLEGSIYQKLESVQGRAVPVYLGDINLQNVYYLDSGREIIHMSLMAWGGEILQQADYISRGREIEYTQNEIQSLGVLHLDLHMPNMLWNAEVERVMFIDFSRAKIIEKNRKRKRSTSPSADESKRVDAHRHPLPIPRKVEPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSF1</accession>
    <name>A0A317WSF1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">MATH and UCH domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_64088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467860.1">
        <property type="nucleotide sequence ID" value="XM_025617563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSF1"/>
    <dbReference type="STRING" id="1450535.A0A317WSF1"/>
    <dbReference type="GeneID" id="37119706"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000334">
        <property type="entry name" value="MATH and UCH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MATH" evidence="7">
        <location>
            <begin position="154"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1214"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="851"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="938"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="851"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY88077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1261" mass="141543" checksum="62672AAA2818A665" modified="2018-10-10" version="1">MDPTPDTGVNVEERLPPVTLITQDSSTEPIRETTVTVNAADEDLSTPPTDTSLSSAPSEPQSLELQPDSREDSHREEAQAPVQADPVSAVRPPQPELEHAYWADIEEDLSVPDDAEMKEIESAADGDYSAYEYDYWEKNFHPDLDDPEYRPVEKARMTWKIKGVRGTPDSPNRAKIMRSPPAYMGGYWWTIKFFPRGNNVGSLSIYIECSPTMPTPDKNLPECDFKVIHGPADAPLDVNTPDVDTTFTPTDDTATWLENFKAHYPPAANQAGSSNKSWRVSAQIGVILYNPDEPRTGWMQSSCHQFNPHNLDWGWTNFHGPWDQIHRRQRGQRQALLRNDTLAFDAYIRIVDDPTRSLWWHASDTEPTWDSLSLTGYRPLGDSVINHSAEVAGLATWVHLAPFCKIIQNANVLEHLNSCDVKPKPLCDALQKFLWQLRSRGQSLQYVDTDMITSTLRNLHEYSGDVCEFWERLRRTLEIELAGTDAVNELAKLFDSPSLDSLPAEAQGQDVINTVPKDYNSRICVPADQAKTTSEAFSWYLGAKPGRWVLPPVLHLELGRQKLDKAARQWRLLYNRVELDEELDLTPWLLDGQCGKYVLYGYIVHRGRRTSGKFFSILRPGGPGTRWLAFDDGSDNRVECLTRKTALGPHLGLDASQKVDHKTGHDVAIAAMYIRTDLVQEFLPGPQGPWDAPESLKEYYETGIYPVHSEPRPVEDEIQVEVYSLPKYDQLGSLFDTYDLMTQSKAENSVMYLTVPRSSNYVDLRKKIAMWASAKSGESSCAEHVRLWQIGHTRDQFGPTLAFARISDLTSTLNFPLKTARFWMQIVSDENAKFFAIADPPQAIEIQSKPEEAVVERAGSESSEDRLSLPEGDAARASSSGTVPENTLEPAFVSHIEVVSQDPVPARLSSSDEHAPGNSENDAVIAAIIAEDIQQMDTDRNPDAVPPAIEEPSETLSPEAEPEVNPIADAPAPSVESEITQPVDHVYYFIQKFDIDAQALRTVGSFFSKKEENIKTAVRRHLKLPPMKDFQIWQRVDGTTVTTMSSGETFEVYVPDGTCFIVGDKLTKDRRSQLNVAGLFGNPDQMVRYLWAESRNHPTRAFSGFKTVDATFTNEYYSGEFKKGYFHGKGKHISDLAATYVGDFVLGKRHGNGFMEYPTGDTYDGDWFEGICHGQGTYVERKTGNKYVGGYKDGKRHGKGISYWEVADEEMDLCQICYGEEQDALFYDCGHVCACVTCARQVDLCPICRKSIVSVVKIYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSX0</accession>
    <name>A0A317WSX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Early growth response protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_556251</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468233.1">
        <property type="nucleotide sequence ID" value="XM_025613852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSX0"/>
    <dbReference type="STRING" id="1450535.A0A317WSX0"/>
    <dbReference type="GeneID" id="37115995"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="583"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY88871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="769" mass="86679" checksum="5B82BC3000B36F34" modified="2018-10-10" version="1">MPRGRPKSHVPPCRFCGKDFRRLEHLQRHERTHTQEKPFACHCGRSFSRQDLFSRHVRLSRCDPRVETPSRDTSSQLYPGSSALQTTRLVNQGIPAPVLPSPASHLSDFVTPGTFDGPPDPLPMEQYPANLSGVLGPDLLCDNFAFSFPDFIPSQFLDTDISLSHLLDQFPSQRQPEPALWQPPVPAGQRAPPDDENQTQRRIPSMDDQLHKTGLEAQLDTAGCAWAVSAQAYKRIMEKIAEKKSALVDFSLPSRCALVRYLEGYFRGFHDHLPFIHVPTFRPEAIELELLLSLAAVGAFQRFEHYKGHQIYMAARSLMDHNARDRRQTLVSQLTRRSPPSVKSTSNSHEPDTPTTPAADPGDTVQLQRTQALIVLMAMSAWGEEILVQDSLAMSSQLASLVRSLGLQQPDHCDRANLTWLEWVAHQQRRRTLLVAYILFNLHCIYFNVPPQILTSEVALCLPSCEAEWKASSATAWNRHCSVSNLQERPFTTTLTQLLNGQDITTDGLIAPFSNYLLIHGLIQRIYFDRQSGSLSHPTILETIETALKCWQCSWEATWESTLDPYSPKGPLGLHSPKLPLGTLPRTPLQQPHPNRLPHPCPHPTSTPQQQHHQLTRSPSLDRAILQCIHALSIPVRVGIPYVARTQTLHWSVQHSICHIECAFLLMRWMQTLSTAVSQSHQGMNCLRPDEQKLLTMARYLVQETHLQEELEEGIRINEGESIIRLMKTTARLWAEISSGIHVFDIVRRIGETLGVIADVLEDIPTTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTU7</accession>
    <name>A0A317WTU7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biogenesis of lysosome-related organelles complex 1 subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_490515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BLOC1S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468426.1">
        <property type="nucleotide sequence ID" value="XM_025609124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTU7"/>
    <dbReference type="STRING" id="1450535.A0A317WTU7"/>
    <dbReference type="GeneID" id="37111267"/>
    <dbReference type="OrthoDB" id="20018at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009395">
        <property type="entry name" value="BLOC1S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073:SF0">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13073">
        <property type="entry name" value="BLOC-1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06320">
        <property type="entry name" value="GCN5L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY89515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="158" mass="17013" checksum="2C5FE049CD17496B" modified="2018-10-10" version="1" fragment="single">TPQPNTNDPDPTPQTIEAISAFTATLHNTATSYTTPLVDRAHTLTTNATNLERQQLDVEKSTAALAKQNDALARVAEEARLGLKEIGDVQNWAEVIERELLVLEDVVGGWRGWFWGEGEVGKGKGKDDGVRNGGEGQGESESQGGAEGGKGSGWLKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVB3</accession>
    <name>A0A317WVB3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_623106</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468677.1">
        <property type="nucleotide sequence ID" value="XM_025617127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVB3"/>
    <dbReference type="STRING" id="1450535.A0A317WVB3"/>
    <dbReference type="GeneID" id="37119270"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24666">
        <property type="entry name" value="zf-C2H2_fungi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY90299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="390" mass="43063" checksum="AFD676362A67D3C3" modified="2018-10-10" version="1">MSAASSSTRVQCTYKDCKRHFISHPAMNQHKLIDHDYCSRCDEDFIDEECLLLHKIKSDKHIVCAFCGREFRSEGGRDAHIRQYHRPKQNLVCTGCGKKFKQAGALVRHVEDDECDEIPMTRFLHEQSKRLLIREALKTGEGDGLPFPDPDGADDVDGGVKLDGSTSILDMENENAEISSPALKRKPDRISSLSSVFDIDDKKGAAGQSTTAKDPLSMMKNLSLKSGVSDNSKEKAKSAARPSKEDNSDPFGVAQIDIGHTLRALDKTWDPMNFFDPFRAKFVCPCDDEFSTSKTFETHVIEKTSGKRSVQCPGCLRIFKTAAALVAHCESASTHCSVNTGLRFSQIIKDVSGGLVKAVGLRDGTVEYAAGDLESKKTGITEKSQDMMEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVT5</accession>
    <name>A0A317WVT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_593304</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468831.1">
        <property type="nucleotide sequence ID" value="XM_025616176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVT5"/>
    <dbReference type="GeneID" id="37118319"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="57"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY90453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="552" mass="59017" checksum="F0C8BA09D1DDCCB7" modified="2018-10-10" version="1">MSPCPTITDAPIPPTTATSQSESDNGWNESKEALQADTDLSPTSTEDYMDGVLLHVIMLCLSVAMFLVSLDTTIISTAIPQITDEFSSTADVGWYGSAFLLGSAVTQAPWGKLYGFFNLKWTYLICLLTFELGSLLCALSHTSAAFIVGRAIAGVGASGIGSGIYTIIGVCAPPRRRPVLVGITGLAFLLASIAGPMVGGVFTTKVSWRWCFWVNLPIGGATFAIVLCFFRTPSVTAHMKASWKEIIFQLDLVGIATLTGALLCLLLGLEWGVSNSWHNRDVIGCLVGFPLLMGLFIANEFFWDSRAMIPRRLLLKQSVAVNIAFTFLVGGAFFLLLYYMPIYFQAVKGDSAADSGIRTLPLVLSAGVTAVIGAIGFGVTGYPAPFLLVGGILISVGGGLLYTLDLATQPRFWIPYQILAGIGIGASLQVPIIMNQAMVEASDMSTMTSMTLFFKCLGASVFMQAGQTIFLDKVKRELLTMSSLADVSANQILAGGLLTSKNIDMESSRGFLTAYFFGLKDVFVLVVALSGLATLLALLVGRDKMDMARLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVZ7</accession>
    <name>A0A317WVZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zf-C2HC5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_534028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468907.1">
        <property type="nucleotide sequence ID" value="XM_025611446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVZ7"/>
    <dbReference type="STRING" id="1450535.A0A317WVZ7"/>
    <dbReference type="GeneID" id="37113589"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180022">
        <property type="term" value="C:RQC-trigger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009349">
        <property type="entry name" value="TRIP4/RQT4_C2HC5_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06221">
        <property type="entry name" value="zf-C2HC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRIP4/RQT4 C2HC5-type zinc finger" evidence="2">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY90529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="518" mass="55604" checksum="AE25FD84472B8AD0" modified="2018-10-10" version="1">MSNSGLISWGVPRLAQLLPLDEESLTQIITYAASLPKEEGADHLKNLLGDSPAALEFIAAFSSRREPPRSEAPSPAPDRASSTAKNNYSGTGSKRGKKSKPPLHSAGPVRRPDNFGNVTGGYRKEDQDEDYMPVSSRSRQDAGTRKGAQDTGPSPLMSSREASAPSSRNQSPAPRPTPAKNPPSAAGPVISDLLPNVKSKAAKSASRTGGSTATGSSSKGSLTTNNINDLTAAIAALEVSTNPTLSSGARKCTCYASIHPLFDPAPNCLNCGKIICSLEGLQPCSFCGTPLLSNDEIQSMIRELRAERGQEKMRAHNDSVHREGGFGPGLGAPSKLDAAKAHRDKLLAFQAQNAKRTRVVDEAADFETPNVASTLWMTPAQRALALKKQQRIMREMEEKARPEWEKKKTIMSLDIKGGKVRRVYQSAEPAEAGPSAEEEAEAKAEEELGDGHRDSSGKAFSHNPLLAAGGLLRPVWKPAEGEQADSGRKERKQTWRRVQDDNDDNEQWILDGGLHGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWA5</accession>
    <name>A0A317WWA5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_534385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468513.1">
        <property type="nucleotide sequence ID" value="XM_025611536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWA5"/>
    <dbReference type="STRING" id="1450535.A0A317WWA5"/>
    <dbReference type="GeneID" id="37113679"/>
    <dbReference type="OrthoDB" id="4509603at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="275" mass="29438" checksum="A49F50867671EAA2" modified="2018-10-10" version="1">MVYFLRIWWRYKLRTSAHNGRFERRRTRQPEVAVQKIELADRGGKRHWLECREAERKKGGEKKAGKAGPSAPGSGRGGIPPGGGAGPGAGSTGDSGGKPASQHPSKPASHNGWSPQMSASHPPRNRNGMPAPPTPAKLPSKASSRNDWDNQQYAPQSPIKPPSNRNGMQPAHAPAVNFPNRITLQDQGDIPLRDAEPNSKAASVGEWEQIALNPPAIPAASKQGSKRSYRPRSAARGPSQAGSRRGQPQYGVDANALMAALQPMTGEAQAPEDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWB2</accession>
    <name>A0A317WWB2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_565010</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468723.1">
        <property type="nucleotide sequence ID" value="XM_025614468.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WWB2"/>
    <dbReference type="GeneID" id="37116611"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="9"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="970"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2364"/>
            <end position="2438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="970"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1137"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1002"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY90345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2449" mass="267770" checksum="07A2E235FDD5DF14" modified="2018-10-10" version="1">MSATHQDPVMPIAVTGIGGRFPGNASNPDKLWEVLLNGESTLTETPKNRFNIDAFYHPHAERSGGQNFRGGHFMDRPVDAFDAPFFSITPNEAKAIDPQQRMCLEVAYEAMENAGLTLDAVSGTNTCCYFGAFNYDYQKILERDPHDMPFYAGTGTGIAAIANRVSWFYNLIGPSVSIDTACSSSLVGLHLACQTLRTGESDMALVGGVNLILTPESNLTLSTLHFVSPDSKSKSFDEKADGYGRGEGTCCLVLKPLDKAIRDGDVIRTVLRNTGCNQDGNTPGLTQPSRSSQKNLIRRVYEDAGLNLEDTGYFEAHGTGTTAGDLTETRVLGETIGKARPSGQPLWVGSVKANLGHLEGASGLAGIVKAIYILESGKIPPQIWFEKLNPRIQLQEWNLAVPTELMEWPYDGARRISVNSFGFAGANAHAILEDACSYLRTHGLEGHHHTNINGLPIMSPKGVSDSRRRESPDSGYNSSTSVEESVTWSGASPKLIVLSAYEESGLTRILDSWNNYLKTKASQLPIARWPRLVEGLAHTAAAGRTRFPWKSFIVVSPREVTSKATMASPIRSSRRPKLAFIFTGQGAQYHGMGHSLMAYEEYCNSINAADAYLKSLGCSWSLKEELARDEQSSRVNDPEYSQPLCIAVQVALVDLLRSIGISPVAVGGHSGGETAAAYAKGAITAEAAWAVAYHRGKLAGILSTIRPEVHGAMLAVNISEADILPYIDKVTKGDIVVACVNSPGSVTISGDAFAIAEMGNILKEAGIVAKELKVNIAYHSPHMEIVASRYRDLLGSIEPLPGASQEPMMFSSVTGGPINNCDLGSEYWVRNLVSQVRFSDAIQAMASYSPRTSAKKTPDYCYVDAIVEIGAHGALQTPMKQTLTAAGAKCEVLGVLHRKKDPRVAFLNAVGLLFQRGSEADIAKANRNTTLDRPLQILVDLPPFPWNHSNRYWHESAIATNFRFKEHPRKDLLGVRDDEGNPSQQRWRHFLRLSENPWIADHMVEDRILYPAAGMLVMALEAARETGDLSQSVDGYELRDVVIRSPLLIPRTGDQPETMIHLQHRGLVAQTLQQPSWQEFNIYSRMKHRAWTHHCSGLVHIQFTAKGGDSMSGMAYEKTQWDEKHRTAYHRASHQCQSTVLPQQFYGRLAEHGLQLGEAFQNHIEIHKNQTQVVCAIKIPDVSGWMPMKFTHNHLIHPCTLDSFLQMIMVTLSENMQEKGLALPASIGKLWISEAMPTKPGTILHAYSDVKPHGLRNAQMDVHISTDDWEGPLVAMEEITVTRVAGDSNALDDQAANDSARRIVSWMNWQEDISYLNGQGLKEFCTGSEINGTLQNPLVTFMGFLGHKYPDLNILEINAEDDKITEQILGALQPVDGEKTPWFKGYTVATIGEATVAMFNAKSQAWGSYFKTIDLSPAQESQHHAMSGHDYDCIIMHRADPEDDDAIARARGLLKDRGTLVILCRNISSRTESDWKNVLRRNRFREIEISIFDNTAQQSSFIPFMLTTAMGEPDSPMPESILIVDPPGEGFRAHNLSASVSNILHNQNVSTSHVSLYETKDLNLTSQCCIVFADLARPILFDIESKMFLILKRLLLEAAGVFWVTSGTTLECERPQAALITGLSRTIRQEQPDLSLITIDLDWKNYNKTSDSCAIVNVVSGWSRGDIDREFAVRDGRLMIPRLRLDRSLNGLVSAVGGVPSKELGLLKQPNRCLTVALASPGMLSSIYFEDDPSYQTLLEDDAVEIEVKASGLNFMDAMVALDQVPERTIGMECSGVVCRTGSAVSKFKLGDRVLTLKLGSFSTFVRSPECMVHPIPAEMTFEMAASIPLNYITAYQALVEAARLKCGESILIHGAAGGVGQAAIMMAKALNAEIFATVGSQEKRDHLQQAYSIPDDHIFNSRDLTFASGIDRLTNGRGVDVVLNSLAGEGLRQSWLRVAPFGRFVELGKRDICRFYLNCHHNASILIEGLVENTGLDMRPFNRSVSFHSINVTGMYQKSVSRAAQALDNALQFYYDHGCQPASPMQVMGYPEISRALQLLASGQVVGKVVLNATDSDMVMTVPPSVPPIQFAEDATYIIVGGLGGIGQYIALWMADHGARNFLFLSRQGSHHPQASVVFEDLSAKGAQATAYQCDISDGEQVERAFRQCSVELPPVKGIMQAAMLLSDATFTQMTPHQWHSGINAKALGTWNLHCAAPEGLDFFVMLSSESGVIGWRGQGNYAASNTFLDALAYHRRALGRPGVSIDVGPVLDVGYMAEKPELRRSVQQQGLIGIKGEELLCILQAALRETADHQGTTCPQLILGVATGGWAAGQGISPPYYHAAAKMGHLREIGAAGRGDDGTKHELQESLAGASSLESATSIISDTLRSRLAQQLGVAVADIDASKPVSAYGVDSLTAVEIRAWSIRDLQAEISILDIASTDSVWLLSTILARSSGLTPRHLLEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WXB6</accession>
    <name>A0A317WXB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">L-asparaginase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_54258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468252.1">
        <property type="nucleotide sequence ID" value="XM_025613098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WXB6"/>
    <dbReference type="GeneID" id="37115241"/>
    <dbReference type="OrthoDB" id="2588474at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010349">
        <property type="entry name" value="Asparaginase_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110">
        <property type="entry name" value="L-ASPARAGINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42110:SF1">
        <property type="entry name" value="L-ASPARAGINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06089">
        <property type="entry name" value="Asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY88890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="354" mass="37574" checksum="DAD99430091C474B" modified="2018-10-10" version="1">MTVSTTNNYVVTNRGSVIENRHQVHAVVTDATGRILYGVGNPKRITLARSAAKPAQVLAILQTGAVEQFGFDEEDLALMCASHSSEDHHIARARGMLAKALLDEGDLRCGGHPAISEAVNRTWIKHDFIPTGICNNCSGKHAGMLAGAKAIGAPTADYHQADHPFQRQVKDVVEELAGLEQDGAQWAIDGCNLPAPAFALHHLARIYARIAHAADCAASVSASTQTQALGRIFHAMAQYPALVGGTGRFCTELMETFAGALIGKVGADGCYAVGLRASDQTRRLGADGAIGIAVKIEDGNLDILYAAVVEILGQFQIAAPDQLQRLAAFHRPQIRNTAGVVTGQTSHQFQMLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY58</accession>
    <name>A0A317WY58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_622751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469017.1">
        <property type="nucleotide sequence ID" value="XM_025617100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY58"/>
    <dbReference type="STRING" id="1450535.A0A317WY58"/>
    <dbReference type="GeneID" id="37119243"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF7">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016467564" evidence="8">
        <location>
            <begin position="18"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY91289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="259" mass="28577" checksum="2F7E1F2F3F524C09" modified="2018-10-10" version="1">MKATILLVTASLSQALAQVSSHPFPWSAPGPDDVRGPCPMLNTLANHGFLPHDGKDITEDRIVAVLNNSLNIAEDLSQFLFKEALTTNPDPNATTFSLSDLSRHNILEHDASLSRQDFYFGDNHDFNQTVFDETRSYWIAPLIDFNAAAHARLARVNTSMATNPTYTESETGHAFSYGESAAYMIVFAEGSETANRSWVEYFFEHERLPQQLGWTKPQESISTSVLIDTVTGIVNASDASVLEVAELIDFVDLHVGPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X213</accession>
    <name>A0A317X213_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_398043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469370.1">
        <property type="nucleotide sequence ID" value="XM_025607379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X213"/>
    <dbReference type="STRING" id="1450535.A0A317X213"/>
    <dbReference type="GeneID" id="37109522"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF18">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY91642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="612" mass="69546" checksum="1BBE8C06AB66A64A" modified="2018-10-10" version="1">MERPKPAYGQACTQCYKAKCRCVRTTNGGNCERCLRLRKRCQPSESLRRRNAQAAEESDARIARLEDKMDGLLSAMQSFVGSGAVPPIHGHGVSQPFPFNTSSSNATGVGFGEGPTTADSSATVSPTSNPVLQYPNYPSPALSSQEDEQIEYFRSRMLPCFPFIYFTPNMTSRYLREHRPCLLQAIHTITTFSTQERLVQIDHLKRLLFTSSLIKVESNIDLLLGVLTYLAWSTDPFLGRADLVSRLMMLAISLVYDLRLFKPSSPDVQIMMTITQGRDENSHEPNDETSNALLERQRAVLACFVLSSNISSHLGRQDALRWTPQMEEGLRVLTLTESCPTDALFVSQVRLQLLKQRADHVRQQDETDITGINHGASAPRLLYVKSLRRQLHELRASFPSDLQIDILNTHAQYVELYINQLAYSISRDYFALKSPGRRGDSDTMLGFQRIECLWQSVENIKAWLDLFYNMPCSKLIGQPFHFWSQMILSITLLKYLSTLQDPEWDCQAVRNTVDLISTMDCMLEKLNLPSKEPELQCNDHLLTYLSKLLTKCREWAEARWNTITQIQDVESVTGTTSQAHQIPDLDQIVWMQSMDLGDDEWFDSVLSIPTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2V0</accession>
    <name>A0A317X2V0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_430497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469725.1">
        <property type="nucleotide sequence ID" value="XM_025607474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2V0"/>
    <dbReference type="GeneID" id="37109617"/>
    <dbReference type="OrthoDB" id="4500700at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY92964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="170" mass="19493" checksum="D9AA9DC2F97D0FAF" modified="2018-10-10" version="1" fragment="single">PLDEPVGNLSKFQGLRSGFQHTEERERLTDALHSIFRTRGNLLHPDAQQDVAQCDFIYDVCMYKSDHTPLLRRMVVDFETEVCIIHDELYRALNIPIERYEGPPISVVGREGKATPLGKVRATWNMPKDENFYCAEFLVMHGVEFDVLLGTSTVRELGLYRRDPALASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X359</accession>
    <name>A0A317X359_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_511988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469825.1">
        <property type="nucleotide sequence ID" value="XM_025609789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X359"/>
    <dbReference type="GeneID" id="37111932"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY93064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="262" mass="29618" checksum="5EC4576AB43E0D1B" modified="2018-10-10" version="1">MISLTGRLPIRHLRTRDPGAMENASLEAELHTIMPKLAIDSHYPAFYLQAKAAIWLDRVLEIVQSPVVASEEGLSHFQAVDRGLVQFLRILVQLGMGTCCEAIAIALNAFFCLHHWRLDPRTPSAFTEQQKDESSQAIRTVLTILADIASDQVYSSESMKELNDGMVEAFPYTITMIYQLLLELRDHFPPSDYRSSAESSPQSLYALQDKINMMKYILVKQTVRWEISRAYIPRVLILAALCSGTHQLSVTPLTYFVLRSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3I2</accession>
    <name>A0A317X3I2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_532917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469940.1">
        <property type="nucleotide sequence ID" value="XM_025611222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3I2"/>
    <dbReference type="STRING" id="1450535.A0A317X3I2"/>
    <dbReference type="GeneID" id="37113365"/>
    <dbReference type="OrthoDB" id="15981at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="188" mass="20815" checksum="0CB0BB1598743E86" modified="2018-10-10" version="1">MSALACCIPRMRTSQSFRNCHSYRLFRTLSLSRSPRSLGLSLPTSSTRLTSTSISNTTPQSINISSLHIHQTRTMSSAAIPDRYKLVYFVPHSHHEACKEAIFATGAGTFPGGKYKRVCFQVPGLGQFLPSEGANPAIGEVGKVETVEEMKVEVMCLGREIMLQAVEALVKAHPYEEVVYEVYKMENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3U7</accession>
    <name>A0A317X3U7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_532960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469997.1">
        <property type="nucleotide sequence ID" value="XM_025611235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3U7"/>
    <dbReference type="STRING" id="1450535.A0A317X3U7"/>
    <dbReference type="GeneID" id="37113378"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF9">
        <property type="entry name" value="DICARBOXYLIC AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="45"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="562" mass="62218" checksum="67CF8F574DF78303" modified="2018-10-10" version="1">MGHKGDGSPDTPVEKQYATDLFTAEENVEPIPGDNELHRALKARHITMIAIGGAIGTGLIIGTGSALAKAGPASILISYSVVGFIVYLVMCGLGEMAAWLPLSSGFTGYAVRFCDPALGFALGWTYWFKYIIVTPNQLTAGALVISYWIHPDRVNAGVWITVFLVLIVSINYFGVRFFGEFEFWLSSFKVIVILGIILLSFILMLGGGPDHDRKGFRYWKDPGAFNTYIDDGAAGRFYAFWATMVSATFAYLGTELVGVTVGEAENPRKTIPRAIKLTFFRIVVFYVVSVLLVGTLVPYNSKELIFATNQSSSAAASPFVVAVKLAGIPVLPHILNACILLFVFSAANSDLYIATRTIYGLSKEGKAPSFLSKTDSRGVPVYALILCSSIACIAYMNVSSDSKTVFRYFVDLVTIFGLLTWISLLVTHIYFVRARQAQNVPLSDLAYRAPLGSPGSYVALAFCILICLTKSYDCFTHNKKWGNFDYKTFITAYLGIPLYLILIFGYKLATKCKGVNPYEADLWTGKDVVDREEEAYARRRAMMEEKHERAGWFYRKFVSWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4Q3</accession>
    <name>A0A317X4Q3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_461704</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469656.1">
        <property type="nucleotide sequence ID" value="XM_025607945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4Q3"/>
    <dbReference type="STRING" id="1450535.A0A317X4Q3"/>
    <dbReference type="GeneID" id="37110088"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF16">
        <property type="entry name" value="BACILYSIN BIOSYNTHESIS OXIDOREDUCTASE BACC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="359" mass="38895" checksum="867EC985CA451107" modified="2018-10-10" version="1">MSPLNYNPTNLKNKTILITGGASGFGAAFSTRWASAGAQIIIGDINPSGAEIVAQIRTETSNPNIHFIHLDVTSWTSQVNFFRQAVQLSPHGGIDAVVANAGINNAAESRFFESPTIDYLSDPNPPPPSLKTVDVNLTGVLYTTHLAQWFLPRNPGSSNLSNESTETDESGRDRHLLLMGSIASLHALASQVPYTITKHAVLGLFRCLRIMAPETTGIRVNIVCPYYTDIGLMSGPARAILAGVPIGKPEDVVEAATYLMANQKCSGRSLATGPKLKLDLPEGGYLKRGEVGKYTVEEGGDKEEQGVWELELHDAETTDVFTDRMLKMVKTVVAAKGWIGWGKGMVEALLWPVTKYWTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4X7</accession>
    <name>A0A317X4X7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">G-patch domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_341523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFP11/STIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470146.1">
        <property type="nucleotide sequence ID" value="XM_025607038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4X7"/>
    <dbReference type="STRING" id="1450535.A0A317X4X7"/>
    <dbReference type="GeneID" id="37109181"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="4">
        <location>
            <begin position="85"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="651"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY93385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="773" mass="87456" checksum="41735F846F7F41CC" modified="2018-10-10" version="1">MDSPPSSPYAGQKRKIADMSPDEEEEEAYRPTMGFRGFARASSRSESPPSHSGLGGARRNPWNNSAQSAMKGGNNNAGKGASSGGNSFAARMMAKMGYIEGQGLGSSGQGIVNPIEAQARPQGAGLGAVREKTKQARTEEKRAAALRGESVDDSSDEERKRRQKKKEECKREGRSGTGTPVARAKPQFRTAREMEKDMEGLEVPNVLKSLIDATGKDQKVLTSTAGLMTPQTFVTQGEGEAWKIAQRARNDLEAFADEWKGLTERKKYIEFEEAQVVEQLDTNQLKADQLTELVAAIGQLEIFQKEDTRAKFDELTDKLESMEMKYRNELDEYRLPETAVAAIHPLFRQAMEEWEPLRDPTYPVSNLRRLQPLLLRKTKDEHTQRQSTSPYETMLYTLWLPRVRSALLNDWDVFESAPVTSLIVAWKELLPSFIYANVLDQLVVPKLTSGLKEWKPRSSSRRHHTSSSNSTRFPWWVFTWLQYLDERHTNPKQPTGLLSDAKRKFRVVLDTWDLSKGLINGIELWRDALGSEFDACLRNHLLPRLGRHLREDFEVNPQDQDLAPLENVLKWKDFFKPNVTGLLLVAEFFPKWHNILYIWLTNDPNYEEVAEWFTWWRSQIPSDINDLTIVDDEWNKGLQTMDLASQLGDRAAAELPPPSSTTTATTAPTTEPPLTSKPLPTEPPRKQKILEEVAFKDILESWCLEQGLIMLPLREAHPQNGQPLFRITASATGKGGVVAFVQGDVVWVQNKKAKETWEPMGLEDRLVERAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X540</accession>
    <name>A0A317X540_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_349590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470467.1">
        <property type="nucleotide sequence ID" value="XM_025607095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X540"/>
    <dbReference type="GeneID" id="37109238"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="81" mass="9550" checksum="22C842BCDCBA02ED" modified="2018-10-10" version="1">MTEASFHSILLSFLYLFIWRYKTRSPGRMVFGGVVDRVFGFALMVCLVVFFDLHLLFPVEPRTSIRVLLSWNMSMLEYHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X552</accession>
    <name>A0A317X552_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_583104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470495.1">
        <property type="nucleotide sequence ID" value="XM_025615533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X552"/>
    <dbReference type="STRING" id="1450535.A0A317X552"/>
    <dbReference type="GeneID" id="37117676"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="55"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="208" mass="23042" checksum="B3B186BDC61DE8A0" modified="2018-10-10" version="1">MPAYTNHIPLKLTITHLIPSKTKYQLIEEVERLDYYVPGGYHPINLGDQLHANRYTIVDKLGFGRSATTWLAEDSTQGRLVALKISTAESALRTAQHEGRILSQLESAKPQSTLFGKTTIPTLLNSFSFSGPNGTHTCLVTDVARVTLHDAKEASYHRLLHLSAARAITAQLILGVQFIHSHGLVHGDLHLANILLRLPHDMQDMTPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5N2</accession>
    <name>A0A317X5N2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_313241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470675.1">
        <property type="nucleotide sequence ID" value="XM_025606842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5N2"/>
    <dbReference type="STRING" id="1450535.A0A317X5N2"/>
    <dbReference type="GeneID" id="37108985"/>
    <dbReference type="OrthoDB" id="4481893at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="432" mass="47317" checksum="FCCC5E53049CBC5D" modified="2018-10-10" version="1">MSAQRPQTKPVSPDLDLRPICVNCRMDFADNSDICIHCDGTQVKSEDYDSDDELVEIKTEPLPSDDEAAIAVAIMESIEVPESIAILESVVMPGSIAISEPMMLPEPVMMIPESIVIPESIATPDTIEIPESIEMHESEYNATAKQAVPAKKDLRLENEPQAASKTAPRASAKVSKARGKAKSPAGSSRKRQPKKSACDDCRRSKKRCVHRDVEEQRTLPPPSTSTRKQTAGPKKKPGPSSKRTKTDNDNSIGDDDDNDDASKTGIKIRIKNVQGDSTETSPTRPAEPEPAPQKRKRGRPRKVSPIKAGAPAAPATEEQEEQEEEEEEEEEEEEEEAVPRKRARRGTPTGDDDQASLQDASVSVALALPSLLEDPLQGASKLAPHVVFSRNLHAKLEDCEGKWQAAMDALRDAKQMLDSWVCQWERGRAGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X689</accession>
    <name>A0A317X689_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_321857</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470907.1">
        <property type="nucleotide sequence ID" value="XM_025606905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X689"/>
    <dbReference type="STRING" id="1450535.A0A317X689"/>
    <dbReference type="GeneID" id="37109048"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000078">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="138"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="538"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="572" mass="61728" checksum="25150C194D0E2492" modified="2018-10-10" version="1">MFSGSSSPPKDRNDSIPRSGAIDTPSLSIHTEEPNANQKKSSPPGGFFTRRTSEDQSSGGEKKRRSSTVTKAASFFTSAKNSFSLSSSPREHSFNNYAIQEQQSLHKFGSMDPALNVPQGSLNNSAGESLPTPRSSFKVGVTEDRNRKCRRTMEDTHAYLYNFLGNPAPLAPVENYSKSLPSPGAPSPTSEEPTSVETDNGYFAIFDGHAGTFAAEWCGKKLHLILEDVMRKNPNTPVPELLDQTFTSVDQQLERLPLKNSGCTAVIALLRWEDRVPSVHSSVGSSTLASTATAVSKGESDSDAGDTPTQAAMSGAASILPTLHEKSTRQRVLYTANVGDARIILCRNGKALRLSYDHKGSDENEGKRIANAGGLILNNRVNGVLAVTRALGDAYLKDLVTGHPYTTETVIQPDSDEFIILACDGLWDVCSDQEAVDLVRNVHDAQDASKILVDHALARFSTDNLSCMVIRFDSDRVKDVINRTVEPIGVDGDSATNVDRGMSEADKIIEGARKSMASAGIADDPATAEKVQSEILQKMSNAEAGPELSVNEHSHERVVNNLKKPEPRNPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6Q1</accession>
    <name>A0A317X6Q1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cora family metal ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_532249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471065.1">
        <property type="nucleotide sequence ID" value="XM_025611083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6Q1"/>
    <dbReference type="STRING" id="1450535.A0A317X6Q1"/>
    <dbReference type="GeneID" id="37113226"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="633" mass="70968" checksum="B98134FDFE4B65C2" modified="2018-10-10" version="1">MSIHSQDHAQLAMGLQSSQDIADVEANPRAPNPPVSPTTKEPPSPPPETFSTAARFNSRETVRNRMRRSTTARSYYREDGAHDPNWQPGTEPGIDPNQPLPAYSTEWMASTPTDLHGKSEITVVDFSQHDMRQYVLDNDTLEPFLAREKEPWVQCRWINVNGLSWDAIRILGNQKGLHRLAIEDLINATNRTKVDWYSDHAYIVLKLQKLIKLKEDDSDSDDDSDDGQSPWLNERRASAASSVSLRRPTKRMLVLEALKDLFRPKSREDDDPDGPSGANVSGLRQTQSKTSVLGDASNVRLMPRSIQRYRGGPNEDRIAFMERHAILAAKGLCVTLEQVSIFLHADNTVTSFFETSADDVEGPIVRRLSSPETMLRQSCDASMVVQAILDAIIDLAIPVTTAYQDVIGDLELEVLTDPDVDQSKSLYVLTSEIAILRNCMQPIVTVINALRDHRSEPVHTPGLGVLRNAGTATPTNDWGPHIGTATPNLKSLGGSSVSISTMCHTYLGDALDHCITIVEGYDQMRRAADNMIDLIFNTIGAYQNESMKQLTLVTCFYLPLTFLTGYFGMNFEQFSAIKHSDSYFWMIAVPFVFATTAFLMRDKLQRYLVLLAQKRLITSSRRNRQRRRATRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X715</accession>
    <name>A0A317X715_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_273114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471165.1">
        <property type="nucleotide sequence ID" value="XM_025606576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X715"/>
    <dbReference type="GeneID" id="37108719"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="166" mass="18264" checksum="B154F40D0FC364FC" modified="2018-10-10" version="1">MRCPTQDFPVKPTDMIEIGATLYLVQGDYGSWMRHLPNIMVLVEGAGTINMIKASAQLLSRLLLSLFTPLTPVKPFMALISNQPRFYMGKSRQSPDPSPVQSHLNAANEPLQSEIDNAGLSVGGKTKAVRASDRDWSMGSPESMSARELSPHVRRLASGRCSRKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7V2</accession>
    <name>A0A317X7V2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">INSIG domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_348061</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470398.1">
        <property type="nucleotide sequence ID" value="XM_025607087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7V2"/>
    <dbReference type="STRING" id="1450535.A0A317X7V2"/>
    <dbReference type="GeneID" id="37109230"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="70"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY93637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="37485" checksum="D805818C48DB3D5D" modified="2018-10-10" version="1">MSDEPTILRPRPRRVFDLTPEEPSTPAEPANPDLLTPRDGGSTSVSRNASIMNLTSSTLYGIYSPTAFESPRDDSSPWGTEAHTPQPGSPRIQPEAPAPGKLQRTRSRLSHGLFRGVILPQALKSAFLFGFGIVYGVITIHLHENHWITPVKLENTHYYGSWQYLAFWGVAGVALGNVLPWFDQFSGEIIDNPKTSRSSDQEAADRTVSWVAVVRSVGAFVGIAFAMRRLPWESTTQASVTLALVNPVLWYLIDRTRTGFFLSTVVGLAGMGVILGLKPDLIPSAETSAPSAPISNITGWDYGLAVEMSQESIAVRTWVASVLFCACVCFGNIGRQLAPESLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8R4</accession>
    <name>A0A317X8R4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_281245</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471436.1">
        <property type="nucleotide sequence ID" value="XM_025606627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8R4"/>
    <dbReference type="STRING" id="1450535.A0A317X8R4"/>
    <dbReference type="GeneID" id="37108770"/>
    <dbReference type="OrthoDB" id="270728at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000187">
        <property type="entry name" value="Probable FAD synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="101"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY94675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="300" mass="33165" checksum="627486D92C05643A" modified="2018-10-10" version="1">MTDSILSSPNGATVAATITTSPTSNHHPTITSSATPNSSDQFPSSTTASLSTIIADCHHKVHNFLAESHPPDSLLSAVQAQTRISLDVVSAALHRYPLSELALSYNGGKDCLVLLVLFLAGLHPHPAPEHGDLTSIPAIYALPPDPFLDVEEFVQWSSRAYHLNVLKYTTDPPRTTIKSTFEDYLFVNPGVKAIFVGTRRTDPHGTKLTHFDRTDSGWPDFVRVHPVIDWHYAEIWAFIRHLGLRYCSLYDRGYTSLGGTADTHPNPKLRVESTGQEAPVQQYKPAYELTEDLEERLGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X928</accession>
    <name>A0A317X928_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_508080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471875.1">
        <property type="nucleotide sequence ID" value="XM_025609648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X928"/>
    <dbReference type="STRING" id="1450535.A0A317X928"/>
    <dbReference type="GeneID" id="37111791"/>
    <dbReference type="OrthoDB" id="5416384at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000023">
        <property type="entry name" value="Fungal specific transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="604"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="604"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="664"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY95114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="828" mass="92235" checksum="0E0BF522C1C12D27" modified="2018-10-10" version="1">MASQFNSSSSRPQFTNPWTDSPSKIIEQSDHSPDSRIAHTLTACTRCRQRKSRCDPGIPRCSPCERSNAKCVYYDSARKSTISRNYIVLLRERARMLEKELAEVEKEFQHAADAELMVRGAGRIRFKENDESRYLGPSSGIAITRLVMEMAKQNTDSKSIKDVVPELTAQEIKDAFAQESSKPTSKVYPMISSTPQPNLPPKHMTYKLIDVFVVKAQAMLPTLHEPTFRQEAEEVLNGSDDPCHNFQLRMVIAISMQKMSTVYAGLADSYYLAALPFLEASLKRMDLRSLQCLALIAQYSMLTPTRTAAYWVVGMAVKLCQDLGLTDESTITRSPSGQLLDPLEIDMRRRLFWIVISMEYGLSHSLGRPNCYSVCHDHINVEFFNPVEDRFITRDGILPGAKIILPKCIAIHFLRMRLLQAEIRRTLYLNKRDVPVDDQDPWFSQMLEKMDKWVASCPKNDGGSGLSEKWFHGRRNTMIVFMFRPSPQVPEPSVDAARKCYDASVFNVAMQREQIATGSVDLTWIFTQSLFMALNTILWSLSYPDIRKEHPIDEVKRHLGVALDAIVLAAQRWPGVESALVLYRSLVAACLRAYATEESFVVHSPSNHATPSSSQDVTTPLSVASPASTSASFHSQSARAANSSIPDSSTSAGTFSRGPSADPSFSFSQGSTSSAVATESLKAAQHPSWDAQLTPQSMSTTTQPSFSSPTYDLPAPSYTDLPFDPTTPYNQFPSIVPGLPGWDPNFSPASTMASQLAYVGAAVDPMGWIDTIGDQYSQYTNGAYPMPPWRGRTLSHQEQMELMETLEDNIPDVSAQLLVQESATFYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9C3</accession>
    <name>A0A317X9C3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Acetate regulatory DNA binding protein facB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_457484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471542.1">
        <property type="nucleotide sequence ID" value="XM_025607748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9C3"/>
    <dbReference type="STRING" id="1450535.A0A317X9C3"/>
    <dbReference type="GeneID" id="37109891"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15485">
        <property type="entry name" value="ZIP_Cat8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000007">
        <property type="entry name" value="C6 transcription factor FacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF12">
        <property type="entry name" value="REGULATORY PROTEIN CAT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="23"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="597"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="766"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="785"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY94781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="862" mass="94741" checksum="090C294634E4AE06" modified="2018-10-10" version="1">MPGILPMKVIKVGNGSQSRIAQACDRCRSKKIRCDGIRPCCTQCANVGFECKTSDKLSRRAFPRGYTESLEERVRALESEVRDLKNLLDEKDEKIDVLSRIHSFSPSRQRSSAAATSPSAPARPSAPDADEGMIQVQHLVQPNESGSTESAALSNTRGFVDAFTNKLVEQNRLSSSVSIKTLTTPPTISHSRVDQTIRTAPRLVSDQLINIFFQEWAPLYPVVHRPTILKAYEQYLSGMESSQGSKHDLAQLNLIFGIAALTSMSRTNQDPAFFEDNWSSILESISSDISLPTMQCYVLAQMYCMIKGDYTSLLRYRGLAVSLSQQLRLHQSQKRFSSNALVAETRKKVFWCQYALDRFTAALTGLPVLLREEDVKTEYPEDIDDENVTETGFLPTLPGESTRISSAIALFAASRVLNKVLEDIYPSDGGYDIPLSKLRSVAERLDEWVKGLPAHLRLEFSQDKPSTNVTSSRSPLLSLVYYYIRSLIHRPAVCFGEEHVRSPSILVVSDSAKHIIQILELLDERRLCLSVSINRKELVFAAGLGLLWQNIGLKRDSKLVKESQKLLTAVIDQLESEESSSAAEFSALAGVLVSLSNSKHGSSGRPQDMSPPLQKPLKSPRRQLQSWKSRLSGTSGPTHQEAPDSPSRRATICGPSAHAAQRHARSSSWTSLPPDNFHAPNMPTNKTAYHSASGTYDGSHMLSSSAPSDPPGGPITVSDWEFVLSDMDRGYSNIFTGIYGGRECGEDSGPFASLTAEFVQKGDPLAAPLSAPQTELQGLSPEAWSASSNSDVPPNQELPAQSVLSYSDEGSADDGVQFNDMRLSPEEQASFLGSFRSVMIPAVEDEADEFALINGWDRRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9H1</accession>
    <name>A0A317X9H1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Solute carrier family 40 member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_532221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in iron transport and iron homeostasis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471043.1">
        <property type="nucleotide sequence ID" value="XM_025611078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9H1"/>
    <dbReference type="STRING" id="1450535.A0A317X9H1"/>
    <dbReference type="GeneID" id="37113221"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17480">
        <property type="entry name" value="MFS_SLC40A1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009716">
        <property type="entry name" value="Ferroportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11660:SF57">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 40 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06963">
        <property type="entry name" value="FPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="510" mass="55368" checksum="3CFB698E49BD8AEF" modified="2018-10-10" version="1">MTTPPLIQTHPESRPSGDSDDPTEPFLPRPSSSGSSAQRNPTPVLIRLYISHFLSTWNSRMFEFGAVLFLATIFPGTLLYASVYALVRSLSAVVLSSWLGSVVDRSNRLRVIRHSIIWQRLPVAASCACFVALLMPSTSTGASLIFVAAVLLACVEKLAATANTVAVERDWAIVVSDALDIPRQDLNASMRRIDLCCKLLAPVVISVIDGFSTRIAIWTVLGVNVSCVVVEYIAIAQVYASIPQLERCHDRSPGIRNESESGQQNSDAIQTATCRISLYIAKVAVPGQEYVASSVFLASLALSLLYLTVLSFGTTMVTYLLHTGFTPLQVSGMRIGAVIAELSGTWAAPFIMGKIGPIRSGLWFLNWQFGCLAAAVAAFAFLDNQSQVVAASLIVGVALSRIGLWGFDLSVQFLVQEGVDEHARARFSSTEMALQNIFELLSFATTIAFPLPEQFKYPVYISYGGIAMAAICFATYVRKERGHLLHTSKCFGGDKKKMALDPRDVIIHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9P6</accession>
    <name>A0A317X9P6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DUF907 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_221649</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471980.1">
        <property type="nucleotide sequence ID" value="XM_025606224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9P6"/>
    <dbReference type="STRING" id="1450535.A0A317X9P6"/>
    <dbReference type="GeneID" id="37108367"/>
    <dbReference type="OrthoDB" id="5212126at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016435110" evidence="9">
        <location>
            <begin position="23"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="24"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="629"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY95219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="746" mass="81232" checksum="232F10494278A408" modified="2018-10-10" version="1">MRLISLVISFLVVLLNSPQAAAVKLIESNALSICQDSSNFTATYFSVTFTPGNRSLSFSFDGVSAISGKVTAELVLEAYGIQVLTKTLDPCEMDISGLCPMNAGAIDVPKAVITVPESVVKSIPNIAYTVPDLDANVRIYINSTDTGESITCVEASLSNGKTVYQKGVGWTTAIISGLGLAASAITSGLGHSNTAAHVAANALSLFSFMQSQAMIGMTSVHMPPIVESWTQNFQWSMGIIHVGFLEDICTWYQRSTGGTASTLLSDLSTTSVQLYKRRKRSDDEEGIVRKATGYFKYYQKRSSASTQTATDSSVIVRGIERVGFKAGIETTNIFLTGLIFFVVFVALVMLLVAIFKVICELLVKNGKMKSDKFQEFRNGWKVVARGILFRLTLIGFPQMSVLCLWEFTKVDSAAEVVLAVIMFISVVAALGWAAVKVMHLAKRSVIMHKNPAYILYSDPTCLNKWGFLYVQYRATAYYFIVPFLGYILIKGMFIGLSQPAPVVQTIALVIIEAGMLIGVSVLRPWMDKKTNIYNISIAAINFLNVIFLLFFSNVFNQPGIVTGVMGVVFFVYNAVFALVLLILVLIASIYAIVSKNPDTRYQPMRDDRGSFIKSGGQLTTELDALGATARGDMKPSPYKSSPFEDDNASFSSGNGASVSRQNLEAPEAPANQTARHSPVSPVDPSLPLFPSDNNSIRNGPPSYDANFGRAPSPVPRGYNSSPFQNPHAYRQQNNPSPWQRGAGYDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9V2</accession>
    <name>A0A317X9V2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plectin/eS10 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_609654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471183.1">
        <property type="nucleotide sequence ID" value="XM_025616585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9V2"/>
    <dbReference type="STRING" id="1450535.A0A317X9V2"/>
    <dbReference type="GeneID" id="37118728"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="63"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY94422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="212" mass="24206" checksum="68D800D18DBEB2F1" modified="2018-10-10" version="1">MQLIRLAERLGPQPLECFPIGNQRTFSLEPAAPLTSSTFKPNHPLHRVVRAIPRRALGTRDNEDRKKIHEYLFREGVLVAKKDFNLPKHGDIDTKNLYVIKALQSLTSRGYVKTQFSWQYYYYTLTPEGLDYLREWLHLPAEVVPATHIKQQRSHAPPRGMMGGEDRERRPRAPREGGYRRREQEGKEGGAPGEFAPSFRGGFGRGRGAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA24</accession>
    <name>A0A317XA24_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription factor SipA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_530182</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472224.1">
        <property type="nucleotide sequence ID" value="XM_025610629.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XA24"/>
    <dbReference type="GeneID" id="37112772"/>
    <dbReference type="OrthoDB" id="10070851at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd07609">
        <property type="entry name" value="BAR_SIP3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13280">
        <property type="entry name" value="PH_SIP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000079">
        <property type="entry name" value="Transcription factor SipA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000349">
        <property type="entry name" value="Transcription factor SipA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039463">
        <property type="entry name" value="Sip3/Lam1_BAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042067">
        <property type="entry name" value="Sip3_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14248">
        <property type="entry name" value="CYCLIN Y, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="305"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="927"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="635"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1393" mass="156412" checksum="1D35B0E525FCA8FA" modified="2018-10-10" version="1">MSTQPQIPLPQVGKLVSVVPVGLKEAALDSPTFRATTLHFSDQIEFLERWLDGYARAASKLSTELAAMESAVNIFLSYSTNPLLVSEAVLDHDYTLQSMKRSGDSSRDMWNGLITTVKKMESLISEPIRTFIQDDLRNFKESRRTLDQTQKQYDYLLARYSSQSKSKEPSSLREDAFQLHEARKAYLKASMDYSIQAPQLRNALDRLLVRVSYDQWRELKIFHNSNGTAFTKWGQEMDRIKGWVHEMEGSERSSKRELLSSRKQIEEAAETAARPSRELEDYSVSTVPYLGSRPLSTASMTKETRPEKQGWVFLRTLSGKPTRTIWVRRWAFLKHGIFGCLVQGSRTGGVEESERIGVLLCSVRAAFQEERRFCFEVKTKSNTIMLQAETQKELMDWIAAFEAAKRKALENPASTDLSVSGKVTVQDPAFAISQPPAPEFAADPSDSLTPRASDDQGSSDRSGMLALPERDPSALRNSSDLSSYRRLTTVDSDSPAREHASRIMQKLDLHRKSNNAVAPSTSLPGIGGGIASLISASHSALGPGSPPLTFDADGNRTRSSTLMTLSNDPPSSLAPVTLANPPAPTSMSKAAVVVSNERGIGLGQADKTGGMPSGMMANLWGSSNWGFMNRIERERMGMPGDQGSGPSDKLSSAANDPSKQFLTAEADTSSGSPATRPKSGSRHRQTVSLDDPSKVQRALQGDTHDYPSFYPPQLKIQDAQFRLLFPDIKREEPLVMVFRATWNPNDQQDFPGRAYVTTQNIYFYSHHFGLVLTTSISLESIKEVTAAPGRDCDFLFLHMIPPPGDDTPGRGTVKTFLEPLRLLQRRLNFLIHNCTAAEPLGLESTFKTLNRMETEALTRTPSLDSWEDVAAGDDKFDGGESVAEAPKKDIGVYIDNDLDMHKKNGNGKDTPKFRLPTQPVQYVPQGDLHLAAEKVLDISAKAVFHILFGDKSAVWQLLLHQRRAKGIKQGPWVRQESNHLRRDLYYQIETADMLGRTHNKEISDYQMIDVLNDHLCYVITDKRTPWHLPFKRSFRLVSKVVITFVAKGKSKLSIYTKVEWLWSPYGLQHIIDKSASHDLEQDALDLVDLVGDQVRRLGAHSRTKKAITIFGHIGRQGFASQFSPQGDLQLEPRNPRVQRTLVQLLFETLVSVLETIVSDLMMWTFAFLRWVWKTTNANKVILILLLSSMLINGFYSSRDAYEWWHDRTVGNFMARIGVSPDNVMTKAIYMRDIDDAIANTTVGHGSENVSDCFATFHQQTVRNPGNTISLGTSGFRDSMTRSAARRIQQTRERLASYRHDLLVALRVVNSIEREVVQSEWERWLRQELRRCRQVQVLLGKREGDEEVDLEVDRTGQSVFAELTDDVQQWYETYCTSCQAEHAQIEDESSFGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAC9</accession>
    <name>A0A317XAC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphotransferase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_552368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472220.1">
        <property type="nucleotide sequence ID" value="XM_025613596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAC9"/>
    <dbReference type="STRING" id="1450535.A0A317XAC9"/>
    <dbReference type="GeneID" id="37115739"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="56"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="556" mass="63513" checksum="B0EE3CF4F077BCD0" modified="2018-10-10" version="1">MSSWSNSRDLFEYTSGRFLFNEELRLAERRIQFDVDALLHAVCRSTNRPVSDLCSVSKLAEGGLNRVLQTTYKDGYTVIARIPYRITVLKRLAVASEVATLDVLRRNGVPVPRVLGYSVDHANPVGAEYILLEKLEGQPLGQVWFSMDNKARVKIMKQIVAAENKFMHIAIPASGSLYYRRDLEQTQLCISLPDQADVSAADQIVVGPTAQHAWWYQERDSLEVDRGPWDSYLACFEAPAKREMEYCKRFGRPRLHVERYLRELYHFQEVSPTLHAELLSDYLKLAPYLEIPSDHPFARPTLRHPDFSPNNVLVDSSNNITGIIDWQHAVVLPLCLCAGIPDYFQNWGDPVSEVLAKPDTKLPEIFHGLGQDEQATIQETMRKRLVHFYYAALTMNQIPHHFDALRDESSMLRAKLFNRAGAPWEGDSQSLRYVMMQVCSKWPMPIDNGKSLGPIKCPVEYSEQAVLQCTKSHDQEQEKLQELTEMREVIGIDSLGWVPDDEHLEQSRSMAQNIKAGLLEQSESDTERTALLEHFPFDDHDEGLSTIDKMSTRSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAK1</accession>
    <name>A0A317XAK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_508705</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472186.1">
        <property type="nucleotide sequence ID" value="XM_025609674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAK1"/>
    <dbReference type="GeneID" id="37111817"/>
    <dbReference type="OrthoDB" id="5427059at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="438" mass="51429" checksum="64105F7661D6FE71" modified="2018-10-10" version="1">MAQPTLEGLPVELHISILFTLPDLNSLWSLILASPTYYGAYQLVQKELLQTLLHKHYAGLVNIADAIAAIRSKGLYAGDMSNKEKIIALLDARRRSEEIRRLGLISGPLPDEPADLQETMQLLRLHNQAIVFLDDYCTSAKRPAWIDETEWNNDIVPLVLSETEKRRILRAFYRLQIHCNIFGALEHSPDEDSGYISDDNEWYAKNKTFSGEEMWHLFFSPMAPWEIEEFGCLWEHCCYRYEAILAEISDSYIKIGFTFLRELPKDQQPPRACVYGDCDDFRFSVNKRESLASKGPALLPDVLREDDFLARRNLVVVNVRWTRDYFYDFDYWPRPDFGPGEVHLLYPADQFDFGTDMDGLRKLLETLLPWERPNLAWERRWSRDDNDFPQLFWDMFEYGADNKHWRWGYAFWENERVIEWKMPMLADDYPFADSSGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBF5</accession>
    <name>A0A317XBF5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UROD/MetE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_581360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471773.1">
        <property type="nucleotide sequence ID" value="XM_025615398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBF5"/>
    <dbReference type="STRING" id="1450535.A0A317XBF5"/>
    <dbReference type="GeneID" id="37117541"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="187"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="408" mass="46476" checksum="1E2FCD80B2C40DC2" modified="2018-10-10" version="1">MANQLLSAPPFRAEHMGSLLRPDNLLAVREKIRDTGISEEAAGLHAVEEETVRDVVKLQQELGYKAVTSGEYNRTRFWGQMWDEFEGTIRLQDAEASMFRLYHPDVVSLIEKDRKVMPGDSVIAGSKLSWNPEKSLSNMHELKLVQQALPESEWGNIKLTMITPAWFHMRYKQGKAYTPEAYANDTEYFQDVTKVYQAELDALYKAGLRNVQFDDPGMAYFCSKEFRQGWEDDKDNTGTVEDLLDAYIQLYNDCLSKIPADMHTGIHLCRGNFIGGRHFAEGSYDIIAKELFENLNMNTFYLEYDTERAGGFEPLKFLPKNKNVVVGVISTKLRELEDKEAMKERIYKAADFVSAGSGETREEALNRICISPQCGFSTHESGYPLSVEDEKNKLALTRQIADEIWGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBL1</accession>
    <name>A0A317XBL1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_483566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471833.1">
        <property type="nucleotide sequence ID" value="XM_025608926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBL1"/>
    <dbReference type="STRING" id="1450535.A0A317XBL1"/>
    <dbReference type="GeneID" id="37111069"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY95072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="541" mass="59674" checksum="BAE2DF2B38EC77E1" modified="2018-10-10" version="1">MDRGTDSYKLSSQSRSKLNAFRYGKRDGLSPNKTPQKTGSEPGHANKENQTSWLNGVVGNERPETGNQKHPTETKESKTLKECPHTPGNRIPLADLISNAEDAFNQAPMQELTPEDYVIWQHVPVSSNQDGMSQTPATRSKKRRHSSSPTSSPLAGTSKSRRRGSLDLQNYQGLIKTPQNDLATDLWNSYVSKTLANGNGELLQPRLTNLLSSSPQTPASMRTGRDSSGLRRSNSCMAEWPSSRAKRRRVDREKFGTGRSIFSRTRSNVIDSGNHQGPDISSLVKKIEETLQKVPRPPPDISDSSPIPARNHVRRNRSASPTEDRKGPAPPSRKTSQVQEPRVIHAVPQDRKPLEESSSDYGDDDFDQDFFDLAEASIDPFVDADSPHHGNVAPSENRENNSAPTEIRLPAQEPKKTDVMNTRNDVDRSTNNEDTFDADEFDDDFDGISDSMEDLLAECDKTPSMKLANPMSVEPLVPKQTMPVAGYGKLPAGKSGSLNQTNMSTESLSGDEFDDDGLDLEAIEQSMVHSEAVGSNNVRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC48</accession>
    <name>A0A317XC48_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_571789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471948.1">
        <property type="nucleotide sequence ID" value="XM_025614887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC48"/>
    <dbReference type="GeneID" id="37117030"/>
    <dbReference type="OrthoDB" id="4508198at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="249"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="349" mass="39777" checksum="BBD10A564F282FD6" modified="2018-10-10" version="1">MPIVPRRSRRRAVKTSGRWTEDERQHLWFLRSQHSTLPWGRFHEQFFPNRSLNALQKAYSIMSLEKKKSDMTDTPKIHGRVVKRPLSDTQDDQPWKQTKRTTDIPFEKSLVEETDDSASSDDESSSSGSESDSDEETPQEPTTSHREKSTPAIETAPGEEAANNDVHQEEETTDPKSPKVAPTKVVPAASPTIENPKPLGVVRTEQKINPSDNHSTSSKVSSHALPPPPVWVQIMNSATRDYRIMDFKIRDAERVASALQEEVDTLKQLNEGKEDKIAALQEDVRKHLQTIRRLQQDENRHTDEMTQQRSANQILSDQIDVLEKKLIIARSQNKCETCARVRELTSRMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCF8</accession>
    <name>A0A317XCF8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_531301</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472143.1">
        <property type="nucleotide sequence ID" value="XM_025610871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCF8"/>
    <dbReference type="STRING" id="1450535.A0A317XCF8"/>
    <dbReference type="GeneID" id="37113014"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="79"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY95382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="518" mass="56327" checksum="427996F28E5A296B" modified="2018-10-10" version="1">MSGSPVVAAIVQDAKVDTVRTVEAETLLSEYAALSEGDKRSQRASFVTRIFPLFFGQNAILATSSEYEDQRQVPWSINCWLQPLVLVTPTSAQQVATALALCRFFSIPFSVRGGGHLQNPGFNSNNGGVVISLSKFNHVKLSDDKSTADVGLGLRWLDVYKALDPHGLAVAGGRIPTVGVPGLLLGGGISFQNSQYGVGAMGVSNYEVVLADSSIVNANAQENTDLFWALKGGGPNFGIVTKMDLVTVPTVSWAEARIYPPTAYPELVKGLMKYHEAIETDNKASLVWHGTSQAILLVFFYCAPVEKPAAFQSFYDIPFAMSFVPPGTRSIYELVQAVASVITSETLHHEFRTMSSLPCLELYEATEKVRREQEEALSDVEGLVLTNVFQPMSSSAMKQSQKNGGTPLGLEPVGQQWFLSMADWKNAKDEDRVREATRKIVDVAEATAKQAGAYLPYRYSNYSSRDQDPLSSYGVDNVAKLNQIAAKYDPEGVFQKLQNGGWLLSKAGTGRRKGLGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCI5</accession>
    <name>A0A317XCI5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_455286</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472592.1">
        <property type="nucleotide sequence ID" value="XM_025607647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCI5"/>
    <dbReference type="GeneID" id="37109790"/>
    <dbReference type="OrthoDB" id="4658148at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="38914" checksum="37B7B464E56DFE58" modified="2018-10-10" version="1" fragment="single">CKNYFKDGIIPESAPFRSNLHICDLTSAPTNNQNHEYGVEISRQLMPIFSTLGDTSLPPCSCHDIKAVRQHIDDYIHTAPNTHPDDYSFFTEKHDTSLDSVCRYVLRDVIQWWACWVGSLDNDKHRWKVLYVALATITDDLMIPPLHLVNGTFRFLGHTLANVLAGLRSENVHPDDIKFLEMCLWRQYIVQYLEKRDPELRAMLVGKATLMTQFRVVTANVAGTAVAVLAGVEIQSQGVVDTAVEMMGIGCCLSMDMAKEALSVLKGEKTETVAGDREQSKSELRWVYARCIEYLNGHACAPVTKRFATSGLVYVFLMDRYRERLNGVRVPISTALQAVLDDLVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCP1</accession>
    <name>A0A317XCP1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable alpha/beta-glucosidase agdC</fullName>
            <ecNumber evidence="5">3.2.1.20</ecNumber>
            <ecNumber evidence="6">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO94DRAFT_484171</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="5"/>
    <dbReference type="EC" id="3.2.1.21" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472118.1">
        <property type="nucleotide sequence ID" value="XM_025608948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCP1"/>
    <dbReference type="SMR" id="A0A317XCP1"/>
    <dbReference type="STRING" id="1450535.A0A317XCP1"/>
    <dbReference type="GeneID" id="37111091"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 19" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016372136" description="Probable alpha/beta-glucosidase agdC" evidence="19">
        <location>
            <begin position="17"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="21">
        <location>
            <begin position="113"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="20">
        <location>
            <begin position="264"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="22">
        <location>
            <begin position="679"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="451"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PWY95357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="869" mass="97020" checksum="68E12F7B886495E7" modified="2018-10-10" version="1">MLGSLLFLLPLAGASSIGSRTSSQECPGYKASNVQTDATSLTADLTLAGAPCNSYGTDLKDLKLLVEYQSDERLHVIIYDADEQIYQVPESVLPRVCSGDSSQDDSVFQFDFVEEPFSFTVSKDDEVLFDTSASTLVFQSQYLKLRTWLPDNPYVYGLGEHSDPLRLPTNNYTRTLWNRDAYGTPNHTNLYGSHPVYYDHRGQAGTYGVFLLNSNGMDIKINKTTDGEQYLEYNALGGVLDFYFFYGENPKQASIEYSKIVGSPAMQSYWTLGFHNCRYGYRDVYELAEVVYNYSQANIPLETMWTDIDYMDKRRVFTLDPQRFPLQKMRELVTYLHDHDQHYIVMVDPAVSVSNNSAYKTGVEQGIFLHTQNGSLYEGAVWPGVTVFPDWFHSDTQDYWDGQFDQFFDADLGVDIDGLWIDMNEASNFCPYPCKDPAAFAISDNLPPAAPPVRPSSPRLLPGFPADFQPSSKRSLKRAQGEKGSKAGLPNRNLTDPPYTIQNAAGVLSMSTIQTDVIHAGEGYAEYDTHNIYGTMMSTASRLAMQSRRPDVRPLVITRSTYAGAGAHVGHWLGDNLSDWVHYRISIAQIVAFASMFQIPMVGADVCGFGSNTTEELCARWASLGAFYTFYRDHNELGNIPQEFYRWPTVAESARKAIDIRYRLLDYIYTALHRQSQTGEPFLQPLFYLYPEDSNTFANDLQFFYGDAILVSPVTNANSTSVDAYFPDDIFYDWYTGAVVRGRGASITLSNVNLTHIPIHVRGGNIVPVRSSSAMTTTELRENGFELIIAPGLDGTASGSLYLDDGDSLEPSAVAEIEIEYSHGVLNIQGEFGQDTPAVVEKCTLLGETGRVEITQSFELSGSKEVKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD95</accession>
    <name>A0A317XD95_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">glucose oxidase</fullName>
            <ecNumber evidence="12">1.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BO94DRAFT_619312</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>beta-D-glucose + O2 = D-glucono-1,5-lactone + H2O2</text>
            <dbReference type="Rhea" id="RHEA:11428"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16217"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.1.3.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:11429"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
            <location evidence="3">Extracellular matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.4" evidence="12"/>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472892.1">
        <property type="nucleotide sequence ID" value="XM_025616852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD95"/>
    <dbReference type="STRING" id="1450535.A0A317XD95"/>
    <dbReference type="GeneID" id="37118995"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046562">
        <property type="term" value="F:beta-D-glucose oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0272">Extracellular matrix</keyword>
    <keyword evidence="9 14" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016393425" description="glucose oxidase" evidence="15">
        <location>
            <begin position="17"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="16">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="519"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="29"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="PWY96131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="585" mass="63219" checksum="11C5EB809ACF6199" modified="2018-10-10" version="1">MVRSLTFLGALSTALAAPTYDYIVVGGGTSGLVIANRLSENPDVSVLIIEAGGSVLNNYNVTDVDGYGLAFGTDIDWQYETVNQPYAGDLTQTLRAGKALSGTSAINGMAYTRAEDVQIDAWQTIGNEGWTWDSLLPYYLKSENLTAPTASQRAEGATYDADVNGEDGPLSVGWPDIPVNNLTTLLNETFEGLGVPWTEDVNGGKMRGLNVFPSTINYTAYVREDAARAYYWPIESRPNLHLLLDTFVNRLVWSDETSEGDITAAGVEITSANGTVSVIDVSQEVIVSAGALKSPAILELSGIGNPAILDKYNITVKVDLPTVGENLQDQTNAGMYASTPSGLTGGKVVIYPNVTDVYGNETSTVAASVRSQLQQWANETAKVSSGTMSAEVLEAMFKVQYDLIFNSQIPIAEILYYPGGTDSLSAQYWALLPFARGNVHIGSADPTVYPTINPNYYKFDWDLDSQIEVSKYIRKTFESAPLSDIVVEETTPGFSDVAADASEEVWTEWLFTQYRSNFHPVGTAIMLPKEKGGVVDTKNVVYGTSNVRVVDASVLPFQVCGHLVSTLYAVAERIADQIKADSSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDZ9</accession>
    <name>A0A317XDZ9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_530094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473484.1">
        <property type="nucleotide sequence ID" value="XM_025610609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDZ9"/>
    <dbReference type="STRING" id="1450535.A0A317XDZ9"/>
    <dbReference type="GeneID" id="37112752"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="147" mass="17152" checksum="F1ADB2501A72B16A" modified="2018-10-10" version="1">MMASLLRPRKSLRDFDDKILTNLASAMQNKATPSETFVARERLAALWTQELLKDFIRLKKPGFRDDDIDVIQRDFLQIISILCYIGWPEWTQFGRIFFGHYGIDGERDRTDASIGKFRLEDLENNAFLGSPWAHKFLSDQYIFPQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE32</accession>
    <name>A0A317XE32_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_15102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473346.1">
        <property type="nucleotide sequence ID" value="XM_025605799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE32"/>
    <dbReference type="GeneID" id="37107942"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="93" mass="10951" checksum="B9886BEBDB2F0DAD" modified="2018-10-10" version="1">MSCFLLQPPPFFLSRWPVGWKWLELLCSQKRLYISHLLESAFLLSFSLISVNPDMGISWMTYEMLIYVLSHRRVGLRVLDVRICLARESCVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XE36</accession>
    <name>A0A317XE36_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_285082</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471571.1">
        <property type="nucleotide sequence ID" value="XM_025606658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XE36"/>
    <dbReference type="STRING" id="1450535.A0A317XE36"/>
    <dbReference type="GeneID" id="37108801"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16207">
        <property type="entry name" value="EFh_ScPlc1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000396">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000201">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000049">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="780"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="896"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="745"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="111"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="745"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1107"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1132"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1152" mass="128066" checksum="B4642DEF686437CB" modified="2018-10-10" version="1">MAYAAASSPSTVNGDTQASLKLTGSLSKTPKLHNVITSVPPAPTPSSAPPYAYPYTNTPNSLRPTYNFSNASSPSGTPLQTATDALRGRIQSFPLIPPAYFELGESAMAVSGSASASGSGDAAIQIPSKGPGLMRRISRGAASKLTRRRQSASQNDKRDRSSGPVIMRRRSDSKTGQNSWESALESSNEEDSNDALDSLGVWCGSEASSLQNENVMTTSRNAGAVAPKVDSAIQHGTILTKVTKKRRKQVRFFLDLDAGKVYWDVSNPTKRFYIDDIKEVRVGADARNYREEHQIPQDVESRWFTIVIADAERSKGRSVKTLHLIAPNDYYLDLWTTTLEHISRYRIGLMAGLAGSGQSEAVLKAHWQREMSRLFPKGLKQGELESLDFGAVESVCRSLHINCSKNMLRAQFFKADNNNKGKLYFSEFSDFVARLKERKDVKAIFKESAVDPEGFTADEFLAFLRDVQNEDVDSDRSYWISIFDRFVRRSRPRAPSLPEHADGGVSRMGLDAFTSFLSSSWNGVYASRSPQSRFDRPLNEYFISSSHNTYLLGRQVAGASSTEAYISALSQGCRCVEIDCWDGADGRPIVSHGRTMTTSVLFADCITVINRYAFISTDFPLILSLEVHCNPEQQLAMVKIMKETFKDQLVLEPLLTNTFVLPSPEELKRRILVKVKTCDEAQGDMRQESANSFISAGRKRSSSSPFMRPMMPEYPAVSTLPPLSGSSTAGPDGVDTFMSQDRRSFTTTSISSATEDSDGALSSLKMERKRRQKSKITKPLSDLGVYTRGYKWHSFSSPESQRYNHVYSFAERSFESICRDADSKAMFERHNRRYLARVYPSGFRLRSSNFDPLKFWRRGVQMAALNWQTYDVGMQMNQAMFAAGTDRTGYVLKPESLRTVNPLDEEKRKGTERKLVRFSVDVISAQQLPRPRSIGPDDSINPYVEIEMFSADDRGQSLVVGEGGMNASARNGMSGIGYPHRRRTKIEQSNGYSPIFNDRFKLSLETKYPDLVFVRWTVWSSLDGRSAGNNSSVQLATFTAKLSSLSQGYRYLPLYDAGGDQYLFSTLFCKIAKEDPVSVQRLDAEELRAERLGLLRQIGQTVFKRSSSTERDKDACSEKGSEIPIGSEDSHSPTSPILTPTVSAASTSSLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEC7</accession>
    <name>A0A317XEC7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_530826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471691.1">
        <property type="nucleotide sequence ID" value="XM_025610761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEC7"/>
    <dbReference type="GeneID" id="37112904"/>
    <dbReference type="OrthoDB" id="4503397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="267" mass="31187" checksum="C5575465CAEAC19E" modified="2018-10-10" version="1">MARSRPARETKTPRRTSQEPQAKLKRPCFKWNKLQDCIMLHGIIKILHPKGFPQNTFKKLEKELGDQYHSDDTLRKRWYIVNDKCDTVKEDRKHRSPENVVWVTESESEEEDGNMRDIDRGGRESGEHYFLSPKSTPGFREDYSPESQTSRTLSPSPHSRPRSRLPEEEPITPTQPSRRSQTRYAQRQRTAPNYSSWERPGRSNPPPPPVKTPGPIRRYRGAPQGQLTPGDDQTPKGPKSDYRRRRRVERVEESVSPLNRSEAPRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEK3</accession>
    <name>A0A317XEK3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_619386</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472983.1">
        <property type="nucleotide sequence ID" value="XM_025616857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEK3"/>
    <dbReference type="STRING" id="1450535.A0A317XEK3"/>
    <dbReference type="GeneID" id="37119000"/>
    <dbReference type="OrthoDB" id="5319341at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="539" mass="61201" checksum="4FEF4754F1510021" modified="2018-10-10" version="1">MTKFLRVETGCLTCRARRVKCDEERPIWRNCAKGPRTCRYKFNPLDGSPSTGARNHDPVPVTPREFYPDVVTSDEHLALSPRLPEHTALQPPPQPSPHPVANLTTILRNAKSRELSHSPLRETHDIYSSPTSTRLSASLGPAGDSESIPTPFRVSDPLRLSDVELLLFRNYVDKISKWVDSFSHDQPFYCQVPVMALHCPMLLHSCLAASAKQLSRVPPHGNTSLQEKYSFYYQQALREMGSFLVEPHYSSSDELLASSIILSTYEIIDVASESFGSHLKGIASLIQSHGIHGDETGIRGATYWTWYRHEVWAAFQSRRRMFLDENYWQPRPLASFAHISMREIANRILFIFGQCITHSVLRSETNHSHNRLHAQTTTTTISPSELDQALEDWKEKLPPSMMPFCSREPKTPATDTRERDLSFMFPFVWFAYPESAISHQLYHASKILLSLHGPCASATDPLKARRELDNSRKEVLIIANSGINEAWGLISTQCLYIAGLVTEGILERQRTIELIEAYQTKTGRHTTCISDQLRKFWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF53</accession>
    <name>A0A317XF53_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_224953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472081.1">
        <property type="nucleotide sequence ID" value="XM_025606249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF53"/>
    <dbReference type="GeneID" id="37108392"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY95320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="115" mass="13597" checksum="6C8F9CC74A6EEFEF" modified="2018-10-10" version="1">MTSYRLWRRDLMSITIQDCWAYPIARCCLRTRYRIMCLGLCLGLYLDLLSIRVPYTYLSGHIRCSIHTRDIDVDRQSELYSQRATTTYASKQFTTFHRARFPSPTPLQQHPSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFZ8</accession>
    <name>A0A317XFZ8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nucleoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_144010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472859.1">
        <property type="nucleotide sequence ID" value="XM_025605742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFZ8"/>
    <dbReference type="STRING" id="1450535.A0A317XFZ8"/>
    <dbReference type="GeneID" id="37107885"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF7">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G04690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY96098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="517" mass="56088" checksum="1A65FD4B185F85BC" modified="2018-10-10" version="1">MGSQAVTNQRLWHEGPSCDTGPLPSPDPADMRIQDLQQGNRLLRSLRQAETWMDRKFGVEAMGIERVPDDQRHPPELLNMLFFWFSALLAPGLIPIGMLGPIFGLSVHTSILLTVLGTLIGSVMPAFAATLSPPSGLRQIAVARYAFGLWGARLCGLLNIIVNGGYGVIAAVVGGQLLAAVSDESIPLAAGIILLVGVAFAISFAGFTMIHHYERHAWVVALVLLCVTYAQAGRYFPAEPSRSSVQGIDFCGCCLSYFAIVFGVCCSWCTIAGDYYVHYPARTSRWLVFGLTYWGQVLPTIFVAILGNYFGGIVMSNEQMAAVYHSGGAGALILATLRPSEWAKVAGILFALTFLASVIIDIYSSALCLQLLATPFRAVPRMVWCGLVSLVVLALAWGGRHQLEAILNDFLSLLGYWTLAFGLILAVEHFWFRPRLGGYDLGAWQDPKRLPVGVAATTTLLLGIGFSFVGMDQTWYIAPAAKRIGAYGGDVGDYLVLASVLVFYPLLRTMEIRILGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UV28</accession>
    <name>A0A317UV28_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_570399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000059">
        <property type="protein sequence ID" value="PWY65276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461401.1">
        <property type="nucleotide sequence ID" value="XM_025614807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UV28"/>
    <dbReference type="GeneID" id="37116950"/>
    <dbReference type="OrthoDB" id="4716584at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY65276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="607" mass="68802" checksum="BC1BAF8BE78CEA57" modified="2018-10-10" version="1">MSHRSTTSDKRVRRFLPEPIETSSRSSRVHQVKLSSRELNPLKQRCLRAPKTKSNLSQQSNDFEAVRRNQPSENGTTQTSFQRSRDRHLQARLGESHLQEQRSSVLSHPRKFQPQLVETEKRSFRRQQTQHTLSFEESIPGVPRVSNNINIVRDPPADDASDVSRESPFSYMSLQQRQETRRHSFRVPDLPAIPSSCSEASDASGCSVAHGSHPTLLLQRAPKSENNPQSHHGNEYSEYVLALATRSAEKQLEEQALAAFPNEQVYQPVDHFAIDKEDEDSVNEDELQVRTRLFPSGKHRRASSADLPWELEYLRRHKEEAEMCDRAMAGTKRLHFPSIDRRSFDGATQSCGNWTTGFGLPQTKQGPSPPMLGDDLVFPQSFSPETTICESNSTEHKYPQDKSYHPPGLWYANSHLFDNCDGGGLWMGTCRSSKFPDSEDSRSVCMRVSGDAGEPTPKCSTGTLTEHEKPPPVYSREVQASMHTNQHISKDEDLDRELNDSVVTQIYNYLSLGYPCVARYYDYELSIVSGIPVADLRRDDLKTDAKGYVSIMSGNSMDKRVAKGGCMRWIALRLYIQEWARKRPRMTEGDGDHGTWGVCERKGSWAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZL2</accession>
    <name>A0A317UZL2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homologous-pairing protein 2 winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_614135</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000055">
        <property type="protein sequence ID" value="PWY65962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461541.1">
        <property type="nucleotide sequence ID" value="XM_025616721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZL2"/>
    <dbReference type="STRING" id="1450535.A0A317UZL2"/>
    <dbReference type="GeneID" id="37118864"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="6">
        <location>
            <begin position="21"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY65962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="203" mass="23071" checksum="F2B4C61F6477B0B3" modified="2018-10-10" version="1">MVQKKGKNDKSSSDDADLAQATEVSANLHNRITKAHTAKALRELHQNKQIEGRAAGKQVVYHAIQETCNEATPEIIATMDWKTERLQEQVTSLQAIENKTRAELAAICGRPLVSELRRDIGQIEQAQEVIRARLDRVRGIDSDSVPIQLEVDAEKDWKHWQNQANIRGRICRDLWRKCSEVVPENMTREELWESLGLEGPCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2V4</accession>
    <name>A0A317V2V4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Caleosin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_540535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000049">
        <property type="protein sequence ID" value="PWY67122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461844.1">
        <property type="nucleotide sequence ID" value="XM_025612937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2V4"/>
    <dbReference type="STRING" id="1450535.A0A317V2V4"/>
    <dbReference type="GeneID" id="37115080"/>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="170"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY67122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="282" mass="32208" checksum="7AED287E7D6D8928" modified="2018-10-10" version="1">MPRKVSFSEAQNPNHEKPIRPPSISMGFPTSVPKCPATESRPPANYTNDYIEKPGVPRGNAAASIDRPEGDEDYSKRYGEYTPLQQHILFWDRDSDGQIYPWDTYNGFRELGFNILFSILATLIINLNFSYPTRLAHSYLPDPWFRVYVDGIHKAKHGSDSNTYDPEGRFVPQSFENMFAKYDHDGDGALSLRELFQMMHGNRCAADPFGWGAAIFEWGTTWLLIHKEGQVWKEDVRGIYDGSLFWKVRAARISIRGWSQGLSIGGSIRGILKMLVDRYTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V4S6</accession>
    <name>A0A317V4S6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">KAR9-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_560981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462100.1">
        <property type="nucleotide sequence ID" value="XM_025614192.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317V4S6"/>
    <dbReference type="GeneID" id="37116335"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="672"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="760"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="823"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1366"/>
            <end position="1613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="872"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1372"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1401"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1456"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1505"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1541"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1593"/>
            <end position="1607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY68078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1613" mass="178097" checksum="9B296F9D946D2476" modified="2018-10-10" version="1">MAPVRASSPSPSIPATPAISSCPSPDRTFSTVSSLSTSSATSADARSSVSISSKRRGYIRPQGAEFAESAKNRESVMSLGSIAHLQYYFARTGLLDGKGAQARDWKKKKPEDMPRLLLTPNARFIDDLTASPTSASPTEEESMDPLDEVYDDEVEVMLPPTVSTYSIKTHHIPPPPKLKALRKDLRDAMEKAERSIESIDSQKEPPAEMVPPRISLSSDDGPDSADDPSRQVPAEATPQTWQEIQGMRVLDTVTFAIRAAKIYYTAHERPDRLASIKNERDIRQELFNVLEVLKRWASRNFADGLRDDERSAIVGWMANVRDMLAREAQLESFEAKERAAWLWTEGEWLGKERERETLFLRSLIGADAQLPTWTAPEENSPPPALLEKLRDGRDLVRAHNFAVKNSKRPFFDIKTYHEDVAKPYRRAENLRFWVKAAELRWETKLELDVMGIVHGNSDEAWKQFDTALLAWCKVVREELVRDWRERRALAERLVARMPFPLILQASAVASWIAPMRAMSAASTATTATADPPDSGPNLSTSQLFSPPPPPPPAVSISAADKATPRRIKSKSSLRSLRSFGSTSHHEDDADESHDPGSDKSLIRPSILRRLSPGLAARVKLLDGSNKTNSPSRIAGAVGRIPEEHIKELESLHQKASSIKIEKKGRAWNALPRLHKDKKQQQSDPGYLEVPDPELPEEILEELEEAATPHSDRLLDLLLGQESAQLEEPSFSEDAIEPEPKVPTLAEEAIEEPVISTLAEEAVEEPEVSTLAEEAVEEPEVSRLTEEVIEEEPEEEPEEQVEEPTLTEVVGEQPEKIVEEVVEEDPVMSIVQPTQSDISEKTDYEKYLQSTSDSESHPPPPPPKETSRPTSTISSNSQSYFNPQGLQRTESIYSFSRASFSNQLSQLTSIALPQPSVLEASIATIATAPAAVRALTGAAEQIQIWVKKASDVLGGLDAEDEVEWAAAAGREGLEGVDKAIIRFEGLINVYVRAIEDVQLRDDIGIVSTDSLQTIVVQMDTIIQSWAQIKNRLRGVKEQVELAMEWEELWANVLGDVGAEVESLSELIFEMEEKRHWTLAGEQDSSASGLDISELETIVEETPSSRRMLSGKRLSIDPILTGPPALDMPVIQTPQDDTNHSNLIALFARIQPLRASLDFLPMRLSMFQSRAEKIFPSACQDLEERRTQLEKRYQTLEADADALQKELNEDRWILVFRNAGGQAQKMFDSVERSIAKLQEAIETGVHIHDPPLFTKRVESYEAKKQHYVAAIERVVGIIRKGVNDRLTVNGETLRLLSDMTSRVDALRASIRAMDDWLEDINFVRSQHLRDSISSIVTMDSPLTGSVADTPGSSPASSVVMTPANPLKGCATPMGTSSRRGSSVSSAARTTMSKMRRYSGIPQAATTLTSKKSALPKATTTLTARSPSRAGAVTPTPAARKSGSRPPAQTPSALANRPRWTTSTNTNDLYTSKPNPSPVRKPSSRPASTVPMGPFRRDMSMSPGPMTARSLSRVSSRLASRSPVRQGSPTPGGKLRRPEGMSNAPRSRQSYAGLSFSRSVSHDYDRGLASPTKAPRPGTALGHSANRRISLIPLPKSKETSRSKLGERPPWRFSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8A5</accession>
    <name>A0A317V8A5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_539751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462576.1">
        <property type="nucleotide sequence ID" value="XM_025612768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8A5"/>
    <dbReference type="GeneID" id="37114911"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016300853" evidence="2">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY70285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="125" mass="13996" checksum="B9668343503C48AE" modified="2018-10-10" version="1" fragment="single">MWWTRCRGWWGGTLYCCAVIHPSANYIHNSRSTFLRSDLTQPFPSNYPKTSSSPTIPPGKHGGIKTPKPTITPHQTRHPILPDHCQGQPLGGLLGRWPPANCTIQQKTGILSHYAQLRIPYKLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8B2</accession>
    <name>A0A317V8B2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNF2 family helicase/ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_590288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462667.1">
        <property type="nucleotide sequence ID" value="XM_025616010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8B2"/>
    <dbReference type="STRING" id="1450535.A0A317V8B2"/>
    <dbReference type="GeneID" id="37118153"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17998">
        <property type="entry name" value="DEXHc_SMARCAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000046">
        <property type="entry name" value="Putative SNF2 family helicase/ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="587"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="941"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="175"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="525"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="445"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY70376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1120" mass="124438" checksum="C536844C23892787" modified="2018-10-10" version="1">MEESVPDTPVGDKKVVHSTPTKDDAEYETVATVPVSHFQPLATQSLTPATQRYTQPTQLVEVPYSAKSNSVVQVAASSPPGPNSSPSRPTPNGGRLSSVMAPAGTSFRPPVTAGPAKRAPVIDLEDGPTYRGGSSDDDGQTTRSTDIKPAMFAKSSDKVADSPLDRFKEITTSAVYNPSSAKRPAAQMDPTPRGMAVKKVRQEGPSRAQPVDFSLSSLQDIDDYQSRVKVERMMKVMPHKSVHACIQALVLKRGNYEDALEHLAKSEKAESSEDELTMDKRASPVAPAKQQIKARGTIQDKWSAMNLQRTLSAQKPPSQPSQISQDDAKPRRRLMRGPKSRASSPSPVRSQPRAETPPKKTGRLVQGRKPVSPQRSESPEAMIISDDSDSGIEEVQGDGQLETKVLNFFNKCSVLELADIAAITEDVAKHVISFRPFRSLDKVRAVPAPTKEETKPKGSRGRKTPKPIGDKIVDKCLDMWVGYEAVDSLVARCEALGRPVAAEMKKWGVDVFGKKEGELELVSINPRDAQSQSHDSGIGTPASQRSEDDSDGPAPGPRKARFISQPGIMREDLKMKDYQIVGINWLSLLFEKDLSCILADDMGLGKTCQVIAFLAHLFEKGIKGPHLVVVPSSTIENWLREFQKFCPTLSVMPYYAGQAERAVIRETIEDNRDSINVIITTYTIAKGKVDAHFLRHMDFCACVYDEGHMLKSSTSVLYEKLIRIPARFRLLLTGTPLQNNLQELASLLGFILPKVFQERKDELQYIFANKAKTVDESHSALLSAQRIERAKSMLKPFVLRRKKHQVIDLPAKISHVEYCEMNVAQREIYDHEQEEVRKLLADRAAGKKTGNKSANILMKLRQAAIHPLLYRRHYDNATLSRMAKACLKEEQWSQSNPDIIYEELQAYNDFECHTMCVTHPHSLGKFGLKNHEWMDSGKVDKLCELLKRFEENGDRALVFSQFTLVMDILENVLEHQHIGFVRLDGRTNVEDRQSILDAFHERTEIPVFLLSTKAGGAGINLACANKVIIFDSSFNPQEDVQAENRAHRVGQTREVEVIRLVTKDTIEEQIYALGQTKLALDQAVAGEDAAESKKAEDAGMKVVEDMVLADMKDHDNPNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V8W6</accession>
    <name>A0A317V8W6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_590130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462708.1">
        <property type="nucleotide sequence ID" value="XM_025615994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V8W6"/>
    <dbReference type="STRING" id="1450535.A0A317V8W6"/>
    <dbReference type="GeneID" id="37118137"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY70814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12493" checksum="B26B7FDE47E64606" modified="2018-10-10" version="1">MGWFDRDSEQGDAYGQLSEFTAGSEVTEEHKAKFSHEFIGGAAAYEAMKAYEEHQAKNGKPESHAQAKEILAGLAGAFIDREVETKGLDFVDRERAKRHARQQLEEASAQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VAZ7</accession>
    <name>A0A317VAZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF410 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_539466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462921.1">
        <property type="nucleotide sequence ID" value="XM_025612707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VAZ7"/>
    <dbReference type="STRING" id="1450535.A0A317VAZ7"/>
    <dbReference type="GeneID" id="37114850"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000272">
        <property type="entry name" value="DUF410 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY71523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="347" mass="37915" checksum="1181EDEBA8BEA530" modified="2018-10-10" version="1">MTSRIDKTIARQQEKIASGAYYEAHQQLRVIAARYIKQANYNAAAEILAGGATALLRAGSQQGASASGGDLAIMLVVEVYTKAGWEITGGDDDTEGRARKKRLIELLHEFPSEEPTRRRFIQEIIGWSGRFGPLERGDPDLHHAAGSVYAEDHEPYDAEKHLIFGTSESAETLAKLEFEWYTHDEPHTAAIYASRAVFPYLLIGNLRSANKAFLIFTSKLSSSNPSLGVQEVSSASSDARVFPALALVNFISMLLLTIQRGSSDLFKQLTAHYASQIRDVGLWDDALSQLGEQYFAIKVPRQSNPLLDMMSGMLFGGGQDNAGARRAPQGRGGSKRVEAPPASLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VB58</accession>
    <name>A0A317VB58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligosaccharyl transferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_569702</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462365.1">
        <property type="nucleotide sequence ID" value="XM_025614750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VB58"/>
    <dbReference type="STRING" id="1450535.A0A317VB58"/>
    <dbReference type="GeneID" id="37116893"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000302">
        <property type="entry name" value="Oligosaccharyl transferase subunit (Gamma), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016466628" evidence="10">
        <location>
            <begin position="20"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY69160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="327" mass="36525" checksum="B513E01E8C63F3C9" modified="2018-10-10" version="1">MKLFNLVVSLLCIFPNAFCIATDSNKFERYRSISRSAPIELTDSSYEDITSKPRDYHVAILLTAADSRYGCTLCREFQPEWELIARSWNKGSKPDDGLQILFATLDFSDGKGTFQKLMLQTAPVLLVFPPTVGPFAKVDDTPLRFDFSGPISADQLYTWINRHLPEGPKPPLVRPINYMRLVSAVTILMGVITLFTVLSPYFLPIMRNRNLWAAFSLIAILLFTSGHMFNHIRKVPYVAGDGRGGISYFAGGFSNQFGMETQIVAAIYAVLSFATIALAMKVPRVADNKAQQVAVIIWGSVLLGMYSFLLNVFKTKNGGYPFFLPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBI2</accession>
    <name>A0A317VBI2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MRS7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_526855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462649.1">
        <property type="nucleotide sequence ID" value="XM_025610367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBI2"/>
    <dbReference type="STRING" id="1450535.A0A317VBI2"/>
    <dbReference type="GeneID" id="37112510"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="251"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="63"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY70358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="543" mass="60017" checksum="6BFA8AA2A9BC23EA" modified="2018-10-10" version="1">MSVTMRSASLVHGNAVLRPNLIARPRLSGALAATTAANLRFNGRGLPSRLSAIAILVPQQRGYATEPPTSTSSSSNSFPPPGFNAEQAKKPLPPDTVQPTGTKGVQKVASNPEQTISSQIDAQNKGKSAELTTIKATDVDGKKEKEAKKLTIGQKIKKEVQHYWDGTKLLATEVKISSRLALKMAAGYELSRREHRQLQRTVKDLGRLVPFSMFVIIPFAELLLPIALKLFPNMLPSTYEGQKAREKKALSLSSTRKEVSGFLKDTLKESGLPVTAATVKNEEFAEFFKKIRTTGESPTPDDVIKVCKIFKDDLTLDNLSRPQLVGICKYMNLNTFGTDAMLRYNIRHRMRQIKRDDRAIFHEGVESLSVPELQMASASRGIRTHGVSPARLREDLSMWLDLRLKQGVPSTLLVLSNAYVYAQGGKEAEMSSQIEALQSVLSSIPEELFHEIELEVHNAEGAATNKQRLEVIKEQQELIEEENEQNSENEEKGVAAPKDIEDIDDKEDVKFEAKFKSQSGEATEAAKEGEKAEVATPAKEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBV7</accession>
    <name>A0A317VBV7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_477085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000038">
        <property type="protein sequence ID" value="PWY70879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462773.1">
        <property type="nucleotide sequence ID" value="XM_025608627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBV7"/>
    <dbReference type="STRING" id="1450535.A0A317VBV7"/>
    <dbReference type="GeneID" id="37110770"/>
    <dbReference type="OrthoDB" id="4498418at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY70879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="140" mass="15199" checksum="DE02D21638855387" modified="2018-10-10" version="1">MPGQDVEFRRGRITAHQLESRRPSYINACLIQSRGSRPPVPCSSCHAQPGTKTFASCRHLPGAWGGACANCKWSDQASRCSVRDEVWTGLTDGTDSAAQDRGLPGGTVRDPILIEDVEGQNINQPILIEEDGDENDPIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VD00</accession>
    <name>A0A317VD00_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Aprataxin-like protein</fullName>
            <ecNumber evidence="4">3.6.1.71</ecNumber>
            <ecNumber evidence="3">3.6.1.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Hit family protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BO94DRAFT_560217</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 3'-end 2'-deoxyribonucleotide-3'-diphospho-5'-guanosine-DNA + H2O = a 3'-end 2'-deoxyribonucleotide 3'-phosphate-DNA + GMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52140"/>
            <dbReference type="Rhea" id="RHEA-COMP:13186"/>
            <dbReference type="Rhea" id="RHEA-COMP:13187"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:136419"/>
            <dbReference type="ChEBI" id="CHEBI:136420"/>
            <dbReference type="EC" id="3.6.1.72"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end adenosine-5'-diphospho-5'-2'-deoxyribonucleoside-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52128"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136413"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5'-end adenosine-5'-diphospho-5'-ribonucleoside-2'-deoxyribonucleotide-DNA + H2O = a 5'-end 5'-phospho-ribonucleoside-2'-deoxyribonucleotide-DNA + AMP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:52132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13182"/>
            <dbReference type="Rhea" id="RHEA-COMP:13183"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136414"/>
            <dbReference type="ChEBI" id="CHEBI:136415"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.71"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.71" evidence="4"/>
    <dbReference type="EC" id="3.6.1.72" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463197.1">
        <property type="nucleotide sequence ID" value="XM_025614131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VD00"/>
    <dbReference type="STRING" id="1450535.A0A317VD00"/>
    <dbReference type="GeneID" id="37116274"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120108">
        <property type="term" value="F:DNA-3'-diphospho-5'-guanosine diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000017">
        <property type="entry name" value="Aprataxin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aprataxin C2HE/C2H2/C2HC zinc finger" evidence="20">
        <location>
            <begin position="202"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00076243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="PWY72244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="263" mass="30367" checksum="A27A9BA31B78F3BE" modified="2018-10-10" version="1">MAESPTLELDSSTEQLLLSPKSKHPKHSNPSSSKQATSKKRAIGGPRDALGAYIAKPESFPSNVVVYYDDDFVVIHDMFPKATLHLLLLPRDPQKTRLHPVEAFQDAEFLEKVRKETKKLRTLAAGELRRIHGKHSAQDKARQEALNVEPPLDELPPGRDWEQEIMCGIHAHPSMNHLHVHVISVDRYSDRVKHRKHYNSFSTPFFINIDDFPLAHDDVRRQPDQEGYLRRDFVCWRCGKGFGNKFAELKLHLEAEFNEWRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFC5</accession>
    <name>A0A317VFC5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_475390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463349.1">
        <property type="nucleotide sequence ID" value="XM_025608564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFC5"/>
    <dbReference type="STRING" id="1450535.A0A317VFC5"/>
    <dbReference type="GeneID" id="37110707"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="3">
        <location>
            <begin position="128"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY73084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="468" mass="52424" checksum="7570789DEAD03120" modified="2018-10-10" version="1">MSSTALPKRVALHRNATDSSVPSSVTPSPLDSPRQSPSSTSLSSLASEAEAESKGKMLDTYGNEFQIPDYTIKQIRDAIPAHCYERKALTSLWYVFRDVFWLATIFYVFHNYVTPETVPSKPARVVLWGLYTVLQGLFGTGVWVLAHECGHQAFSPSKVLNDTVGWICHSALLVPYFSWKISHGKHHKATGNIARDMVFVPKTRDQYATRVGKAVHELNELMEETPIATALNLILQQLFGWPMYLFTNVTGHNNHERQPEGRGKGKQNGYFGGVNHFNPSSPLYEAKDAKLIALSDLGLAITGSVLYLVGSKYGWMNLLIWYGIPYLWVNHWLVAITYLQHTDPTLPHYQPEVWNFARGAAATIDRDFGFVGRHILHGIIETHVLHHYVSTIPFYHADEASEAIKKVMGSHYRTEAHTGWTGFFKALWTSARVCHWVEPTEGSQGESSGVLFYRNTNGIGVPPAKLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFF6</accession>
    <name>A0A317VFF6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_261034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463000.1">
        <property type="nucleotide sequence ID" value="XM_025606493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFF6"/>
    <dbReference type="GeneID" id="37108636"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY71602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="94" mass="10640" checksum="DD3C8DE7CAA02210" modified="2018-10-10" version="1">MGRFGWHGLGRLSENFIVYCCSFIACLPLSYPLVLHMGETTGYWCTWKLTCANGPWVGVMRWGGGFHKLPLLSFSLDFSFLLIISFILVGTWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGT3</accession>
    <name>A0A317VGT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sister chromatid cohesion protein Dcc1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_560197</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463171.1">
        <property type="nucleotide sequence ID" value="XM_025614129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGT3"/>
    <dbReference type="STRING" id="1450535.A0A317VGT3"/>
    <dbReference type="GeneID" id="37116272"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY72218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="422" mass="47163" checksum="76DEF6602DA0CA2A" modified="2018-10-10" version="1">MSTQSAQSILFTHTAPQQAFRLLELPADLAELLSSDNPPTYEHPEPMSYLLSYIILINPNHSLEIKSPTPSSQESNPTDPPTDTTREYINLCTPTQTYRIRQVQSSNSLHILRPSDDGIQRGNLAVVGGPTTTEDPVLADMNLSETMTTIAKCGSTLELHTPQEGFNIIPVLEGLLGRYDSLSDGNTEQGRLSESTDRRKIIEGVFADVPVSRMQCGRAWREVCAFVLPDTGRGWVPTAKVKIGVWKRAVEGSVLQGIDLGKQFLVRDVWRSVLDENGEGEWPRELFEAVVRRVCEAGDSDGGLLMEGEMKWASIDKEGCVRWVGETYLEAVAPTANAALGRSEFLNAWKDHLPEGWREEVALSKLTEDKHRFPDPTTICFVNDDDRQKLKKNLSTDASASTTAKKTRNWHELFKNQKRQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGY4</accession>
    <name>A0A317VGY4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_569008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463480.1">
        <property type="nucleotide sequence ID" value="XM_025614711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGY4"/>
    <dbReference type="STRING" id="1450535.A0A317VGY4"/>
    <dbReference type="GeneID" id="37116854"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY73215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="326" mass="35431" checksum="52E1A1F0670C52F8" modified="2018-10-10" version="1">MALTRKSYTVGIVCPKIVEMIPIVAFLDKQHPPLPSHCSTYQDAYTFGCIGNHNVIVAVLPETGNIKAASAVARLKKEFNSIEIGIVVGVAGGIPDTDQFDIRLGDVVVGKATGTNYAAILFDQGKQHPDKFEQTGLLSNPPEFLMTHIEALRLKHERQGDLVENVQQARTQLQLSGTRDCVHQGHPDCKTCPPDKLVNRAYPRQNPPNPPNSPKVHFGPIGSPSALIRDATTREELRRKLGVIAVEMEAAGSAGQLPCLVVRGICDYADSHKNKRWQPYAAATAAAYASERRHGVKRGGGQVPDIQWGVSYEVGLVLSGRDLKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VH21</accession>
    <name>A0A317VH21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_589619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463241.1">
        <property type="nucleotide sequence ID" value="XM_025615958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VH21"/>
    <dbReference type="STRING" id="1450535.A0A317VH21"/>
    <dbReference type="GeneID" id="37118101"/>
    <dbReference type="OrthoDB" id="4505037at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY72467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="397" mass="45247" checksum="30C5A03C782AB065" modified="2018-10-10" version="1">MPTLLEILSRPIPPIVCKAAEGSLTFHRDWKPVERLAVWKEFSYDNVMKLFEEVLQFDFRADIHEPSRELTSNEKDVWGEDSLKHTLSRSLVPVIPQCLAKRWDRMHPALQQAPAELVPSGFAKVSSKWTSGGVRKRNYRYPFAQVQFYCMQNHTRYGWIITDRELVVIRCSVQESSSSSGFGGAVSTPRRPRPLSYSAQILTSPSSHSDPSFASIAGYVDDGSDYEPGLLEWQSIPFDAQGPGILTVRLALWALAMLGAAEVSTTLQSQYHPLHSYTSLDEGFIHLSTGHMTFDDYDDASHVFTRNDRSVSYDNNFSSFHAEDVHHILWDESTRKWKVILLDPIAPNYTVPVQNEFWSRLRAASYSWEQMGQGEYGWVRLGRQRPLFPPLIWQSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VHN8</accession>
    <name>A0A317VHN8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_474879</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463585.1">
        <property type="nucleotide sequence ID" value="XM_025608534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VHN8"/>
    <dbReference type="STRING" id="1450535.A0A317VHN8"/>
    <dbReference type="GeneID" id="37110677"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="318"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="432"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="526"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="597"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY73833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="715" mass="77310" checksum="C8C397D8DAC2D3A3" modified="2018-10-10" version="1">MPVQTSSPTLPDSFPSFMSVFGRSPEFSDKEERTAIIKPLRVPTNVTVNTSRRPLPFKHRESISSMTSASTDSSPTTTISTFDPPSAVDTSPSSSPESPSSMPLSYPTFMPLAHKPECPPHSAAPAAIPNPSTDTPNVARPDSPGRRARNLKNLSLRMPLPSQGSRPPIATASVVESTSQHHLSAPPSPIHVPPKGMRRKPANLTIRTPGFDRSFSSNMDEMIPPTPHALRHTESSPSLTSVFSPSFGPKGGMQLPRPMTHHGARRPSATSESNLSPLQTVPDEESASGGVLHELAEEDDHLDSRESTRRNERGYPNGPIQIYDSGVFLYLEPTAPEASRFDVVVNVAKEVANPFTNTSGGTGTVVSTLRNGLARSNRLSTGEPWTAMSDVSFKSAFEYPPSDESSPATPQNDSSGPEYVHVGWDHNSEILDDLFPLCELIESRISEGKKVLVHCQLGASRSASLVIAYGLYKNRELDFNSVYEMVKERSRWVSPNMSLIYQLTDFRSRLLRGSLSKAAPEEWFVGGARRSSEPQPPHTGRTDASEASTPGYTSGCSDAEQCSSNGLSQASLSSLSAPSTNQTTPISIENLGFSQTLSHKRSLSPRPLPFRQASYQMGSNGRTLPPEPAAPSWRPEGGPYSLAKTDIFVQDAAEGANSLFSPRTTGFMAAPLSRSIADCLDDGPHGLRFGSRVADPRSPPPGTERLIMRNIDEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJP9</accession>
    <name>A0A317VJP9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">BO94DRAFT_589239</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJP9"/>
    <dbReference type="STRING" id="1450535.A0A317VJP9"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000328">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="209"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY74563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="289" mass="31768" checksum="722BF0FF9E0F10CC" modified="2018-10-10" version="1">MSKLGNRADWADDEEFDDPSALPAQQITTNKDGTKTIVSYRFNDEGKKVKVTRKIKTTVVREHVNPQVAERRTWAKFGLEKGNAPGPSFDTTSVGENIVFRPSVNWKIQAAEAEKNGGEKGSMKDQLKDKKVKCRICSGEHFTARCPFKDTMAPVEEPTGGIEGGAGGEEPAAGGLGSGTSSYVPPHLRKGAAGGGERMAGKYEKDDLATLRVTNVSELAEEAELRDLFERFGRVTRVFLARDRETQRAKGFAFISFADRSDAARACEKMDGFGYRHLILRVEFAKRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLK2</accession>
    <name>A0A317VLK2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_538863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000031">
        <property type="protein sequence ID" value="PWY73818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463570.1">
        <property type="nucleotide sequence ID" value="XM_025612575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLK2"/>
    <dbReference type="STRING" id="1450535.A0A317VLK2"/>
    <dbReference type="GeneID" id="37114718"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03461">
        <property type="entry name" value="1_2-HQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039390">
        <property type="entry name" value="1_2-HQD/HQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="7">
        <location>
            <begin position="105"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY73818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="292" mass="32930" checksum="2F672E965A08E7FA" modified="2018-10-10" version="1">MSRFDPHFTDNVISSMGPNTTPRFRQLMTGLIRHVHDFARENELTVDEWMAGVKLLNWAGQMSDDKRNEGQLVCDVIGLESLVDEITYTLATEAPDAPTATAILGPFFRADTPYRPNGANIVLTPPKPIPGEMAYMHGRVVDFETKQPLVGATVEVWQASTNGLYEQQDPEQEEFNLRGKFRTDEDGRYGFYCLRPTPYPVPDDGPAGKLLKLMDRHPFRPAHIHIIATYDNYKPLTTQIFDSKDQYLTNDSVFAVKDSLIVDFVPRKDDPQAGLELQYDVKLVKAPAQVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQ93</accession>
    <name>A0A317VQ93_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_209027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464112.1">
        <property type="nucleotide sequence ID" value="XM_025606141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQ93"/>
    <dbReference type="GeneID" id="37108284"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY76115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="105" mass="11528" checksum="2957AF1EC66D276C" modified="2018-10-10" version="1">MWRWWLKSDSRNAYLQHTCPYRPNSLPWETCSCPADCAAERKTRAASSSPWVYPGLVPIPWYGQNLPIPVSTSSLTLALSGAVAGGSTPLGFIARWDNDEAACQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQX4</accession>
    <name>A0A317VQX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_499792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463935.1">
        <property type="nucleotide sequence ID" value="XM_025609393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQX4"/>
    <dbReference type="STRING" id="1450535.A0A317VQX4"/>
    <dbReference type="GeneID" id="37111536"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="604"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="615"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY75308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="674" mass="76252" checksum="CABA36FF14D17FB6" modified="2018-10-10" version="1">MAQRKARTGLQHRAAEDQSNSRRSMVACNRCRNRKTRCAGNPPYACAACAEVGHECVYSEAEKRVSIPESYFRQLRSQAQANRRADEGRSVSFPNPPAPIQSSPSNVEVPLERDDWWYNGTEHLFLNRSGEHHYVGASSTTHLAKRLNPTSTNLAWDVRPLYDDPSSLRRSAPRALPQLPPFEYAKRLYWVQYVYIGTIFSLIQPHDFEERLHIVYSQPPDLLNRESCLVYCQVLLVIAFGLMYSVNQWSGDDGPPGFKYFKHALRFLPDIHEEGSIFFVEILCYVAYYMQNLNRRDAAFLYIGLALRMAISLGLHQEVLDPGISEEDRNRRRRAWWSVYSLDRLLSVKSGNPITIHDEDIGTTWPQPVSATDMVPWPSVVLTYYTQLSRILGRIGEEIYRKKPRSGSNLLASVQSITDELSDWLRRVPDRLRIDFSRLGTHINRESVSIFLHFYSCVNMTARPLVFYVIQRRLDAEAGGSATDDWREGLSQNTVAVIDSCVAAARATTLIMDAAAKHNLVATYGYLDGEYVFSAALLLVMVNAAFPHNTANARAMEISISLLRSMADRGNTNLAARHSLLLELRSSIGHNRARTEGDAVEVPITPSSTQQTTPLNNVAGPSTNSTWTPQQDLPSMQEISFNFDINDDPGLWEEVLGQIDIDMDTDWIENTLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VRU4</accession>
    <name>A0A317VRU4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_588869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464008.1">
        <property type="nucleotide sequence ID" value="XM_025615912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VRU4"/>
    <dbReference type="GeneID" id="37118055"/>
    <dbReference type="OrthoDB" id="5176563at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY76011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="143" mass="15786" checksum="E177C9425DABF634" modified="2018-10-10" version="1">MLSLGSYMYLIVSSTAAIKTSVRQFLFTVAIRVNETFDILADNLAGGDYDSTQIAPASYSPMQGDTITFLLMGITCHYEYLNAEQIHLNAVNSNDTVIVFGQGAQHGIYTCTDCESYPGEFGDTVRTCFDYVTEWLGKSGRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSU2</accession>
    <name>A0A317VSU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_627172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464094.1">
        <property type="nucleotide sequence ID" value="XM_025617396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSU2"/>
    <dbReference type="STRING" id="1450535.A0A317VSU2"/>
    <dbReference type="GeneID" id="37119539"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="146"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="679" mass="75942" checksum="47497D65252CCA28" modified="2018-10-10" version="1">MRIPLGNPEEIRGKQSTCDLCKLVIDCAAAHYVPGFRSFNHSEPIVLLIDGGKIEIHYPEHGDVQIAVYLRSEHNSSFEERPGAPQEQHRTPTDVPEYIDWSKVLEWLESTPYMALRGELGNWPDGMKVIDVKQNRVIGAPKDCRYFALSYVWGNVKALDLPDWPAFSREDLPATIRDAFVVCERLGVPYLWVDQLCIRQGDPKDVKVQIDQMGRIYNHAACALVALAGSDLYYGLPGVTKPRRWTHVELGQAKLTILSLPPDNCIRRNIWNSRGWTFQEALLARQLLLFAEYEVYHASSCDGRRWYNCEIYRSVHRGHKMNPLPLPSDYLFALEEYTTRRLTMETDRVRACTTVLQAAHGGELYHGIPVERIDEAVLWTTVSPGLKAGSTDFPSWSWASPRGPIQYEFKAMVGLAVWAIPKDHPHASVVLCRPRRGTSLSLTTPPPRGNLGSPEIPPGGCLGHIIKAWLQGCIEERFPVQSVNHEALANCWTTYADFWESAFGGGDYGTLFPVTAIQTALSVPSSILVYGAAAQFSVKQQTTECTSSTPSFALFTAGPEGRLAGTVYLDAQEMDGSVQADLEFLALSVAYGNHIMAEQCQQCCDDTVWDTARKMMTGMNVTANDRAWNTALEETTVLNVMAIRREQCRPSLARRLGVGQIALQRWVEARPQFGTIVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VSZ4</accession>
    <name>A0A317VSZ4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine rich repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_604925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464244.1">
        <property type="nucleotide sequence ID" value="XM_025616466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VSZ4"/>
    <dbReference type="STRING" id="1450535.A0A317VSZ4"/>
    <dbReference type="GeneID" id="37118609"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="801"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="877" mass="96590" checksum="D7E7B4120E558463" modified="2018-10-10" version="1">MDIVPPSYQTATTRDAWSIIAQYIPSSDLCAAVLVCRKWHGLFMPFLWGDPASHFGTDNDAVYVALTRFRRTLKYARLEVRMLTHTLHLPPALSEIYGGPRPEWLREILESLPCLQSLMVSKLPFFDHNAMTALKGCGTPGETDAASQTYNPNATSQGIAETLLRFPGLTYLDLSYTTPARDRILEHLQVLKLRGIGLKDNDAEFLANAIERRVRFLDLRNNFLTDMSIRSLLQASFLPPGAEDGPRRGPPLISNRKFLRNPPLDEQVLKALTQPLTGRSWVEDLPQAGITHLYIADNPISVEGAASLLASSRLYALDSISRMEYSLNSPQDDPHELPGAEKLIPILGTTARENLTYLRAHHAICTVDGPSRETATLDMLLPELSGGIESEVPREAELGTNHEIYELPSNEAAVFELPGTPVPQPSNWYSRSSESGRKPTIYEDNPLPERRRGSVFAPEVVETDRANDEARLGDTHATISSSRLPHGISISSISSIPSITLDSVGSIPQCSSPLSAEDPRALKIQELLAKRPKSLPRRDSKGNYFPYLHPSHVPHLETLVLTDVPSHVLANSPILTSLIRFITACSNEALLATLQAGSDYSLPPGRARARAEQERVRSLFALRRLVLEITPTVQTNKLSRWTPSSYRTGASKSSTGDRDSENLWSAAIGDFSFFGEEECGVPDAYSGKYFPMAALNEKVTLIPDDDDSGRTGVSETDMASSPSMLHTSHLSSQPNSFDPATTPRGMRSHSPFQGQGGDSGASREEIPDVDLVAELASFRRTKKAEYENMLRGNRRRRDTISTVSSRFSPSVSSSQTFSPSPSLNTLTASPAPFISIAHYLEGHWKGEVKIVRNAAPKGRSGVVDMYGNYFEKGYLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VT78</accession>
    <name>A0A317VT78_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Aquaporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_473722</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464139.1">
        <property type="nucleotide sequence ID" value="XM_025608487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VT78"/>
    <dbReference type="STRING" id="1450535.A0A317VT78"/>
    <dbReference type="GeneID" id="37110630"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000022">
        <property type="entry name" value="MIP aquaporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF24">
        <property type="entry name" value="MIP AQUAPORIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="157"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY76142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="517" mass="56747" checksum="EA7C33322B942B7B" modified="2018-10-10" version="1">MVHPMRSLNKELDQVDTESRGYRSSDTTEGAPSNPEHDEEPSELEPGHGVSRNKSYGTQRTDFSRKKSHGTQRTTPSQNRSYRSQQPDINRNLSYDTQAQFSVAGPNAYHAPIAQRGAYMHPEYEALNPQYGNQGDGPIWSLAQPLPHVVRDGMRYGALPEDRMEEREGRGEEEGGEGREEGREEGRDRPPPAADEPPTDMPQNETPPNEVGFFNTWAKIRWHLKEPLGEWLGTTIAITLGLCGGLATYTSQEQAGSFVSLSACWGFSFMIGVYIVGGISGGHLNPAITISMSLWRGFPARKCAIYILAQLIGAITAGGLAYAIYHDAIMNLAAESKVPQSQSTASQAMLTLPKQFVSPATAFFNEFLGTAILVGTIMALGDDSNAPPGAGMQAFIIGILITVLILALGYNTGGAFNGPRDFGPRLVAVMAGWGGHLFTEYHAWWIWGPWVADIFGGLFGAFVYDLVVFTGGESPINYPPRRRKRALLIKEKNLRSKLRMGRRKIGDLERAVEENQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VTQ6</accession>
    <name>A0A317VTQ6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarate reductase</fullName>
            <ecNumber evidence="4">1.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_538616</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Irreversibly catalyzes the reduction of fumarate to succinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + NAD(+) = fumarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18281"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463947.1">
        <property type="nucleotide sequence ID" value="XM_025612529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VTQ6"/>
    <dbReference type="STRING" id="1450535.A0A317VTQ6"/>
    <dbReference type="GeneID" id="37114672"/>
    <dbReference type="OrthoDB" id="10252157at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016156">
        <property type="term" value="F:fumarate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050315">
        <property type="entry name" value="FAD-oxidoreductase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010960">
        <property type="entry name" value="Flavocytochrome_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01813">
        <property type="entry name" value="flavo_cyto_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43400:SF12">
        <property type="entry name" value="FUMARATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0274">FAD</keyword>
    <keyword evidence="1 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="5">
        <location>
            <begin position="6"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY75320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="482" mass="51252" checksum="B5A71DBC4298003C" modified="2018-10-10" version="1">MTPSTIIIIGTGLAGLTTTTQLLTHRIPVLLLERFPKPGGNSIKASSGISGAPTRFQPLPNLDSIASFQADTVSSAGGPYVSATGAEKARREKLVQTLVERSAEGIYWLTDEMGVDLSRVTRLGGHSVARTHRGAGKKTPGFDIVSTLLGKVGGDELVKMETGRRVTRILRDEGGGKVTGVEYTVAKEGNETVLERAYGPVVVASGGFAGDARGLLAQYRPDLAGIPSTNEEREGTQPLLQEIGAAVVDMEQVQVHPTGFLEGGDGEAMVKILAAEALRGEGGVLVLGDGRRFVNELETREKVTGEVMEQAERLPTKARQWDVKLVLDEGAAAALESHLGFYMWKGLIRKTTVGELGEEMPALEGTLREYVDVVSGKKKDEFGRESFGNWTLTEVKPESVVYVGKVTPVVHFTMGGVVINERSQVLDGQGQPIPGLWAAGEITGGLHGQNRLGGSSLLECVVFGRIAGDEAATFYQGLEACS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUJ4</accession>
    <name>A0A317VUJ4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_558913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464548.1">
        <property type="nucleotide sequence ID" value="XM_025614035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUJ4"/>
    <dbReference type="GeneID" id="37116178"/>
    <dbReference type="OrthoDB" id="5230585at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF3">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="181"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="368" mass="41317" checksum="C580A493CFE3ABAA" modified="2018-10-10" version="1">MASIEYPSSPASVSRQHQADGEAPRQGPMIDLGVEDLESPIEDMEIVAKLKDRLEHVVRLYNSGKLLFPRALLEGLNQQIEAGKEEVCIHDLDDVPSTHSLKVPALCSHLATTYCIGYTSIQLLTYIHPSFPTMILSDQAPVSILYTHYPSHPDGTLEEVCAAFNKTRMEWLESGTCQELQSHLSSMRFSSRIHKIVAFGLGTLAKVQNDHISMRSYAQHAAIATMATILRRRGISGGKEIQCYAQDPWYDETDVEFLKSIGITVVNDPKGFLEIDEFTLVFSVCPNIPVKQIVADVQWPGAMIWNTVSEGEETKQWQKRLRSGEEFWMGPLITDPDSKRVCDMVSHYIKSPLLDPEDFFGDLTVYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXL8</accession>
    <name>A0A317VXL8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_181241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464844.1">
        <property type="nucleotide sequence ID" value="XM_025605976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXL8"/>
    <dbReference type="GeneID" id="37108119"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="115" mass="13147" checksum="6676FF151B618A3A" modified="2018-10-10" version="1">MGGITHASDLQFPSRNFKLLLHPDTGCCNIRDLDLPSCLSVPLCWTPLWGRMVLVVTVTNNTSGGRARSCRIGLKHWRSNRWRWLVAYLCLQLLVPVSLVAKQHDHWLRVQTTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYU0</accession>
    <name>A0A317VYU0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7624 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_189478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464694.1">
        <property type="nucleotide sequence ID" value="XM_025606034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYU0"/>
    <dbReference type="STRING" id="1450535.A0A317VYU0"/>
    <dbReference type="GeneID" id="37108177"/>
    <dbReference type="OrthoDB" id="5230484at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056041">
        <property type="entry name" value="DUF7624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24616">
        <property type="entry name" value="DUF7624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7624" evidence="2">
        <location>
            <begin position="524"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="648" mass="71995" checksum="0EB29751669F3B06" modified="2018-10-10" version="1">MKQTGESLMVLSYVKLGLQRQQLIHRTLQTTLGLNSQYIVYKIQTTNAGCNDIQVRSDDDEPPQSVIHAPAGFGNFLSGSPTKVNGQQCSNLPSSSRSDDVPSLASNVVAYSYPVTESEKIRKRIPNGPTSPPPLTTSIQPANDWCERPTPRAQTRQDFLDIRQNTHSVNQKEVNIAHDHHREKPLVTGPSVDGGSGMLGITDAKDTRQRIDRTSEALESKAVHLSDDEAEIAALRAALAECWALCNTLATLSCIHRERHSYTVDTSEDTWKSCWRLCQVLYDSQSDNYALQVNPTLDLCKHFCQTLFETRVQNDEGSDSVLRVSFELNNHLYNTHDRKLPDAFRERTLDFYITLCHRLMKQRTLMSETDTLLSACWSLAEMLFSIRQSIKERKNLGEELLGSAVQACWELCDIFREGWTSRTLRSSDRGTPRPSQATFMQAFQQTKQPESDLNDEFIGQRGNPETPTTIFDDTATVSPDDAPVQNIFVLGESSGPASHATWSSNSSNISGKSQASEQTSSTRTVKTSSKDPNLTIVLDLVTQAAINSGFQDVGQQSFSSFVKSLSSDAFGSMPWQVALLKNYKRLVAFNPAFRSVGPSARASAADVASAVTVMVQGGQYPWLRDLYRLVFGFHIEEAASRKSMTLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W163</accession>
    <name>A0A317W163_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_471228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465243.1">
        <property type="nucleotide sequence ID" value="XM_025608372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W163"/>
    <dbReference type="GeneID" id="37110515"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="607" mass="69415" checksum="8F7CC3554662A587" modified="2018-10-10" version="1">MSIQGILDGPWADQYHSVQSSMTKLWQQQFHPRRLRARPIRTLMLLVATCFFALMLLSHSSEPSVSYWLKFPSYPPSRERPEDTRMLFPGGHTLNRNDSLPHNLQKSNPSFHLLIPASHKSSSLCRTLTSSMILNYPPPTLISYGKAVPEGYTEYAAMVDRIAGIYNYLAYSSQMKDNDLVLIVDSQDSVFQLPPEVLIQRFQNLLRENNAKLLQKYGTVTVDRPYRTGSQETVQKYSQRIMFAASKECFPGLNLDAGCVTVPQSSLPPDAYGWKTDIHPQGHLNRPRWLKPGAVIGQAADLKMLYAEVLRFVHQHRNARGDYLAMTQMFGRQEYVRELERQSTANGFKEWLYTLIGISDASNITGATQPHLELGTRYEYGIGVDYESRLFFNMRNAKMDVEWLHYNNVSKTSAVQMQHGVPREKRLLIPSDITPESIGNPFIQPKFGKDDWPNPPLNDTLDKLPNPRNHTWHNLPLLTNIHSASVPALLHLDGDHTVLDKWWSEMWYQPWARALLRKYMRTPNGFDAAQSSLLGGQEWWDMRGGKGGLWTDKGEWLAYTEVCGSYDKELFNDELGPFGKENGEDADEPVYNRFGNVIKGKEKAEVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1X5</accession>
    <name>A0A317W1X5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_537988</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464692.1">
        <property type="nucleotide sequence ID" value="XM_025612391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1X5"/>
    <dbReference type="STRING" id="1450535.A0A317W1X5"/>
    <dbReference type="GeneID" id="37114534"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="343"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY78180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="931" mass="103077" checksum="442474E29EE202B3" modified="2018-10-10" version="1">MVGSQDSRRQSKRSRAGDAAMGKTMQTDDVRIKRRRTSQINNDMIKSHKSLECKENKNRGDNLNTSTATSVTTVQKTQMLLNPWSSTSVVAGQYSNLDPIFTPDDEYLLLGLETAVHVYSLATSRLIRTLQAKDGDSIVGYKLSPEDSKILYIFTLNGSISKWEWLSGEQSSYWDTCHKTISVEVCLTDAGSDCLFFLRERKDGKRGIAIEHSSDEKSRENIILETNVQINNLKIASQGQFIMAYGDQNVFFGRTRLGKPSEPAQYTWREVNLPVNIMCIDVRHNATSNRSAARSPRDRKQYDKIDLVLGELGGSILIYHDILRFLDDEEGRQNGKTLTPRRLHWHRSSVNSVRWSKDGNYIISGGNESVMVLWQLDTGRKQFLPHLSSPIGNIAVSTSGNSYAVKLADNSIIVLSARELQPSSIITGLQLCPKMTNADGENASGVQPSYGAVAAALHPQNPDQLLITVPASRQTTREGHPLVNASTLQTYDIRTNSHISRQALARTNATTLKISPEGSHIVTPDVSHLSVSKDGKWMATIDNWSPNVRDMQALYYRDSGFNRLSEDSQEIFLKFWRWSSSSNLWELVTRIDSPHFSDKGPARVLHIAARAHSTEFATIGSDAVLRFWCPSIRQRSGLKSDGLDQPTETWKCRSAVDLKTFFDVGMAGALSAASMDFSQDGSVLAVCLGTTTCLNRGLAILIDAQKCTVRYSRVGLYMDLPSAAAFVGCNLVIASRQSVSIWDTVDDLVRTIELPGPGDISSNQPRLLAVNPETQTFAVSAESLQSPPVSRKNRLLQSHIQVYDMSVLSLLSETVLRRHPVALLSAVHSSDYVVVDSAANVQRIGRLDKSLQSNSHSLDLTTHLIKGSGLANLFGQQDEGKPQDSQYSSMDFDWDTQNPQKELASVFDDAPPFVMPPANMIFRNVVDVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W515</accession>
    <name>A0A317W515_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_147517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465722.1">
        <property type="nucleotide sequence ID" value="XM_025605772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W515"/>
    <dbReference type="GeneID" id="37107915"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY81654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="100" mass="11145" checksum="A9937F1FFB008A6F" modified="2018-10-10" version="1">MEVMEQILSSSGGHAFTNQGSSTLATAISQWRKTALSFRIVLRSATGQEMSSQRRRGETLKRRPTSRARGAAATNRRRLLHAVLLLTSHFSLSSHQHDQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W552</accession>
    <name>A0A317W552_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_471198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465311.1">
        <property type="nucleotide sequence ID" value="XM_025608371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W552"/>
    <dbReference type="STRING" id="1450535.A0A317W552"/>
    <dbReference type="GeneID" id="37110514"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="105"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="291"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY80452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="622" mass="68970" checksum="0BE3D41A0A83C868" modified="2018-10-10" version="1">MRPDGISSTNGSSHALNGSAASPSQKAAFSHTLNGQGAFATSHRGVRTNGSQKASVGPPSYFGHDREEVTRILIQSLFELGYDGAATLLSKESGYQLESPAVATFRNAVLEGRWTEAEHILVQSFYPDGGGRGGSGVDQGTNKEKLVLVEHAQKNEMLFYLRQQKFLELLEARDLAAALIVLRHELTPLNYDIGRLHALSSLLMCPLEHLHDQAGWDGPISSSRERLLSELSRSISPSVMIPDNRLAILLDHVKHNQINQCLYHNTASPPSLYSDHMCDRKDFPLRASIELSQHSDEVWWCQFSNDGTKLVTASKDQTVIIYDTSTFAVLQRLLGHEDGVAQCSWSPDDSKIITCSQDKTARVWSVETGRCLLTINQHRHPVTAAAWAPDGESFVTGALDVNAQLCHWGMRGQTLYVWPDGFRVQDCAITPDGRRLIAADLDQKVHVYNFATREEEYCLALKSKPTSVAVSRDSRHMLINSADGQIQLVDINTTDVVRRFSGQKQGHFVIRSVFGGAAENFIVSGSEDSRVYIFHKEAGTLVEALEGHIRGCVNSMSWNPRDPGMFASAGDDCLVKIRQAQGRVDRWLYSYQRTTVNIQLQLNPVPRKEHAVIHHLPNLEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHI6</accession>
    <name>A0A317WHI6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_467633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466746.1">
        <property type="nucleotide sequence ID" value="XM_025608213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHI6"/>
    <dbReference type="STRING" id="1450535.A0A317WHI6"/>
    <dbReference type="GeneID" id="37110356"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF21">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY85729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="545" mass="58663" checksum="B4AA33AC83386ACF" modified="2018-10-10" version="1">MDLDLGSKTAQAASDDPPVEQGDLQLLATLGYKQELRRHYSTVQVFAIAFSIMGLLPSIASTLSYSIPAGPVGMVWVCLATYAGSALVLTVSAGWFAASVFIFIVALAMADLASAMPTAGGLYFWTHYFSGEKWKNPLSFVVGYSNSLGLIGGVCSIDYGFATMLLSVVSIARDGNWTASRPVLYGTYVACVVVHGLIAIFCAPIMPKIQSACIFSNVGLVLATVLALPIGKAVRGGQINSGAYVFGHSENLITWPQGWTFMLSWMSPIWTIGAFDSCVHMSEEASHAARAVPLGIIWSAGLCGLLGFVSLAIIAAVINPDLNAVLNSNFGQPMAQIYYDALGKSGALGFMVVVAVVQFFMGLSLVVAASRQSWAFSRDGALPFSSFFRHVSKRVRFQPVRMVCFVVLISVILGLLSLIDDAAASALFSLAVAGNDLAWMVPILSRLVWGKDRFRPGEFYTGWLSKPIAITAVVYLTFVIILSMFPTEGPNPSPQDMNYTIVINGTLWLGAMLYYVIYARKVYKGPQMTVSESPTFSEMGVQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WI89</accession>
    <name>A0A317WI89_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low-temperature viability protein ltv1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_535899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466772.1">
        <property type="nucleotide sequence ID" value="XM_025611890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WI89"/>
    <dbReference type="STRING" id="1450535.A0A317WI89"/>
    <dbReference type="GeneID" id="37114033"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY85755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="491" mass="54027" checksum="0F229D4731855811" modified="2018-10-10" version="1">MPPRKQWIDKKHATTYQLFHRAQNDPLIHDPSADDRVLAPVYGPAPTSSNASASASQHRGLNLADLNQSFGAAAVRKNEGEAANYGIYYDDSKYDYMQHLRELGMGAGDAHFVEAKTKGKDKGKGLKLEDALRQVSLDDGRSEFGGAESVYSHDMRSTASSYVRQPTYQDQQNVPDAIAGFQPDMDPRLREVLEALEDEEYVDENDNEDVFGQLTTRAEEMDQGDWEDTLFDDVEEEDDGWESDATEKAPVQMNTTDARARYQDTEQPDGELPVHDEPAPDMHPEDQGWMREFAKFKKDAKGKPIAPAAPASVVPSEQQSTLASTVFTVGGTPIRRKKRKGALTNPSAYSMTSSSLARTEGHRLLDDRFERVEALYSLDEEDEFDDSMSVVSGMTGMTNMTGMTGISTVSSQAPSLVDANGEAVRPSHNFNNVMDDFLAGWDDKTSAQAKRKGAKAKRGKNGNEAIGIRMLDEVRQGLGPARVTGKVSGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ93</accession>
    <name>A0A317WJ93_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_80856</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466990.1">
        <property type="nucleotide sequence ID" value="XM_025617684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ93"/>
    <dbReference type="STRING" id="1450535.A0A317WJ93"/>
    <dbReference type="GeneID" id="37119827"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY86399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51804" checksum="01A022450C5B0BAF" modified="2018-10-10" version="1">MEVQSTNDKAACPFCGFQFNHRSSLIRHLKNNCNKKQPQRRKSCNQCVADKAKCNLKRPSCSRCSMRHIACMYAGPEPESPGIASAAPSVPPTPNPSGLDPSPTFQPQALASSFDPSLFEPFFSDLGCWTSLQSSELALRSPEQMESLELLSFPENIGCASPAVTPPVLSQQHQPNSNPNEVALANHSMELIFRVLRTWPQMLADEFQMPPIFHSTHFDPQAKLPRPLATCITLAKMWHGQREGAEGIVRETILKELDLIVHQKSEDLDEMTLLAVMQAAVIYTIILLSPSTASQTAPDNEEMVFRKVEALVTHVVRGGLFLTEERAQTRPCWDAWVHVTSKRRAVLALYLLHWAYSVLHKVPCFDCRDLGFMPAPAPKVLWEARSEQEWNTRYIHWLARWSGQIYLQAEFGHIPPGPTLNTRAEKWLGEADEFGFLMVSILNATDYEPPGLKMLQPHNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJ98</accession>
    <name>A0A317WJ98_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_586111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467117.1">
        <property type="nucleotide sequence ID" value="XM_025615737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJ98"/>
    <dbReference type="STRING" id="1450535.A0A317WJ98"/>
    <dbReference type="GeneID" id="37117880"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY86526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="33521" checksum="7DC3ADC04329C019" modified="2018-10-10" version="1">MENEYMTIRLVQEKSKVPAPTIYVYEDYPENSVGVPFMFMECFNGNAGIKMCQDIPPEHKLSIYTALAEAQVEIYNIELPQFGSIVGKNEDGTYQIGPAPGVGGPFDTTAEYYKACSIHEKFGSTRDQLRAASLNLADEIEASVDAFKPLLGEKAEYISVNNTGPFRMCHGRFGHAKTVFDDKFHLLGVLDWKAAFAAPCELAALFALCLTVVPPAMDVPWNYDESGCPVDAVLKERFADREHYIAIVKQIEEEKGFTSGHRLSTALEDTQRQHIANAMRLYEEGKAGFYSKVLEGFAEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WNH7</accession>
    <name>A0A317WNH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_491803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 60S ribosomal subunit synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467706.1">
        <property type="nucleotide sequence ID" value="XM_025609164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WNH7"/>
    <dbReference type="STRING" id="1450535.A0A317WNH7"/>
    <dbReference type="GeneID" id="37111307"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="299"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="477"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY87923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="526" mass="58558" checksum="48C09733B190E619" modified="2018-10-10" version="1">MADFLLFESPMGYSLFKVAHQGDSVGNRLKEVQEGVNDLATFGKMVELASFLPFENNKQALGEINDVSEGVASDTLISFLELNLPKPNKKKKVILGLSDKALAGSIKSAFSFVDCETGDTSEVVQDMLRGVRLHASKLLKQLREGDMDTAQLGLGHAYSRAKVKFSVQRDDNHIIQAIAILDQLDKAINTFSMRVREWYSWHFPELYKIVSENQRYAQVALFVQDKKDLTDDKLHDLAALVEDDEGVAQSIIDAAKHSMGQEISETDMENVISFAQRVVSLSKYRKSLHAYLISKMSVVAPNLAALIGEIVGARLISHAGSLTNLSKYPASTVQILGAEKALFRALKTKGNTPKYGLLYHSSFIGRAGPKNKGRISRFLANKCSIASRIDNFSEEPSTKFGEALKQQVEERLEFYATGAAPTKNEVAMKNAMDAVLADIDVDGGESDDEMKDADAEEAEKKDKEKKKEKKDKKEKKEKKEKSEKKEKGEKEEKKKKRKSDVGEGESDKKKRKHDSDAEPSKKKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WPX3</accession>
    <name>A0A317WPX3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_566144</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467530.1">
        <property type="nucleotide sequence ID" value="XM_025614542.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WPX3"/>
    <dbReference type="GeneID" id="37116685"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.690:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="709"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="103"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="495"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="533"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="611"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="786"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="857"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="944"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1102"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="237"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="278"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="405"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1102"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY87322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1786" mass="191157" checksum="1463AD7B215A762C" modified="2018-10-10" version="1">MQPYSKYSFEELRLGDYNQGRRFGNGSGQAGAFGTSAFGGSGFGQQQSTGFGSTSSPFGGGTSAAPSGFGQTQTAGGFGANANTNSNPLFGAAKPATGGLFGSGTGTSGASQPGLFGGTTSTTGGFGSGTGTGTGGFGTGGSLFGNNTNTANTAQQQQKPLFGGSGTTGTGFGGGFGTQNTSTASPFSGSAPTSSPFGGQQQTQTGTGLFGGGLGQQNQAQNQQQTQNKGLFGGFGTNTQQPQTGTTSLFGNTGAATGTGAAGSSLFGQNNQQPQQQATGGSLFGNNQQTGTSSLFGGAQQQGQKSLFGGSTTGTGTGTGTGTGAFGGFGNTQNAQTGAGGLFGGAQNQQQQKPSLFGSTAGAGGSLFGGQSTTPQNAGSSLFGSTNQPQQTGGLGTSSLFGNTQQAQPQQAQQPQQPAPGSLQASLLDGNPYGNQSIFSGLPAPTASSPGPLATPLSSSTKQKQRTPLPVYKITPNAANRLLTPPKRQGYGFSYSTYGSPSSSTSTPGGLGGSVLGGSLRGSVNGNLGRSSFSKSFSTSNLRKSFDPESDSVLSPGALSSGTSRLSSGSLKRLTIDRSLRNDLFARPASTPAAPITNGEEVVQPVDKMKKKVSFDSSSEPPATGGEIVPVQSQSSEPTSEELGFLRSIRKSGTINGISSVKTTESPARPEIESVRGNELAAVPENAEPSATAGSPSRLPFVPGGDPQPGDYWMKPTRAEINKLPREQQKKYVGFTVGRQRCGKVTFDEPVDLTTVDLDRIFGHLVDIGVRKITVYPDETIKPPMGKGLNVPSTLSIENSWPRGRDKKSPSPLTSGPLFDKHVDRLVKVHNTEFVAYEKETGTWVFRVPHYTTYGLDYDSDEDEEGESLNQSTLSAAPDTPTPKAQTPANADTTMGSEMMSAFSTDDSFVGSMAGVDDDTFDFKKRKIVPGAFGNQIMETVEDQHSVSGDDDEESFLGESSTGSTIEQDGDDITESQHSGESVVGLDEGEEMDMAGTFPDLHQTVERDDTQSTDTYMELTQPSLRPWNTPSKPRLDLSGDWAEHLQRTISPRKQDRDALREIQAIAFTDRPLHEDTPKQTAADSRQKGFATSIDLMNSLFQQPRKQQAPSPLKTQSVRPKGLEWPYNKQPKTFAGESNELSADDLAFHHSFKPRWGPVNSLLCMKNDVADIYSGDSRWQHKLSVTGEGRDISLLEFSKTVEPSNMLDAQRMQSIVSRVDGVPFARLAKADFRQFAQASSLVQSDHERLLWQLANILFNDEIEDDISAGVPHQLRSKYLHRIKKDRLSRLWEGIVREKHAQAVGKIGSAEERAFYLLCSHRVEEACKLLVASQNFHLATLVAQIGRDPTTRADMAQQIEMWRQNNVYSEMSEPVRALYELLAGNALRSEGKSTGALEDRVSTFTFSERFELDWFQAFGLRLWYSITDDEPIEAAVCQFVDDLYEGNEPAFPSPLDQDSTLDRESPLWVLLKVYSTTRGAVRSVHLHAQEFPAALLPESVSGDKLTNRLSFQLCQLLATSIGRHDSFQLNTTQLDQLVWDYAWELSCGGKLGRTLFVLLHLSRASDRERAIKETLARFAPQLPESVTLEGQTNVMWNYLTQDLQLPESWVWVSKALYARDTGDTAREVDYLVRGKNWNDAHATFCRIVGPTAVIEGDYATLEMLVSGFGEEPERKVRGWATGGGIYEDFLRLATAKGGKRDATRLARLVSALVKMADKVSQGSGVEGLEERVAFREMSRAVASWTGREDTKAIELSSVLSLPLTGDARLAQTAEMSRRYYSLVMAGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQA7</accession>
    <name>A0A317WQA7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_74573</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467515.1">
        <property type="nucleotide sequence ID" value="XM_025617642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQA7"/>
    <dbReference type="GeneID" id="37119785"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY87307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="25291" checksum="5E9EE2117752CF13" modified="2018-10-10" version="1">MDGVVRMQAARASRARFQTNLNQQNRPKWIAKVRCFPVHSFAALLALIAAACVLLLLLLPNLMAVLRRFLFPFFFVFLIFLNSCPILFCSRRMLFSSFLFMVFFPFPLNLFVLIFFRTGLEGERKLLHTRMKRSLLFLFFFFSSPEENSGNQIGLLRPWCLVHSIDHRSRRHRSRGRNRKIWENARPSPDRTINSRPPLPKICQSQNSNNRSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQD3</accession>
    <name>A0A317WQD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobic surface binding protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_585885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467545.1">
        <property type="nucleotide sequence ID" value="XM_025615720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQD3"/>
    <dbReference type="STRING" id="1450535.A0A317WQD3"/>
    <dbReference type="GeneID" id="37117863"/>
    <dbReference type="OrthoDB" id="3485059at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF1">
        <property type="entry name" value="HYDROPHOBIC SURFACE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016371346" description="Hydrophobic surface binding protein A" evidence="1">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="17615" checksum="03406EDC5C310C6D" modified="2018-10-10" version="1">MLAKSLLAALLAVSATASPIIKRDAATVLSDLETILSDVETLDSVVSSWDGSLLTALTILTDYNNLKSALDTAITDTEATSTLSDSDSSSITSEVQTLGTSIVATLDTIIDKESVAASAGVSSTLLSSVETLQTSTNTLGADLEAIATSSDAETIASVVTEVDAAFSSAIAAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQD4</accession>
    <name>A0A317WQD4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_545744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468005.1">
        <property type="nucleotide sequence ID" value="XM_025613255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQD4"/>
    <dbReference type="GeneID" id="37115398"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY88643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="162" mass="17213" checksum="BDF62A227E2EF82B" modified="2018-10-10" version="1">MTMPLSSSISLCSLSAPPHPSPTPISFHPTGTPTCSLRLHDIACAYSVPMLPLGIAAYITIGNPGANYSPARLDRADSPPPSADEHYASDQISFMCLSGKPGRINTMTAHVDLPALYQGICDEVRQGQWKGEYPEESSLTYLTFLGTLSQTSGSGLSILAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRM3</accession>
    <name>A0A317WRM3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_516297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467735.1">
        <property type="nucleotide sequence ID" value="XM_025609957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRM3"/>
    <dbReference type="GeneID" id="37112100"/>
    <dbReference type="OrthoDB" id="3204049at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="444" mass="51999" checksum="258BE19CAF665FF4" modified="2018-10-10" version="1">MAHQAHNICWNILANNLIHRSPTYPEAELVSNLYFRFKPTQGKEIGYFAESFARNIAEHTQCERQKYPANFDPIQPDEVVLNNKTAERIRPIAYKWCKSYSGWSPAKKVLEDTPGVCPHRSDDFFACGCPLPFTERKGSAFSRPCIYTHCYEFFHENTAAFYNLQVVNALLVLGEMETVLRICNSKNELAKWMMVRDCNCMVPDRGWDHVFRAALHFYLALNILTCFPELWDPISRQAGNKKKSEEYRGTLMYQKTLRTWTQEESNNEVPCYPHRQFFGLESHFYRSGKIKRYQKQPAFLALLAERKTLADIARVEEYLRIKRLPQELVLQITALAGYDSRRARRLPVPHDPLHKDNRRELRQYLTFCWKIMVRCNMMAQELGTEINWVSEVIHALGDMVTVPPGKKLFTTEWYEPDDIWPNGFNRSTMRGGNQEFPYSFRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRP7</accession>
    <name>A0A317WRP7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane fusion mating protein FIG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_60421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467765.1">
        <property type="nucleotide sequence ID" value="XM_025616454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRP7"/>
    <dbReference type="STRING" id="1450535.A0A317WRP7"/>
    <dbReference type="GeneID" id="37118597"/>
    <dbReference type="OrthoDB" id="3550957at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016509">
        <property type="entry name" value="Fig1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28092:SF1">
        <property type="entry name" value="FACTOR-INDUCED GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007138">
        <property type="entry name" value="FIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="267" mass="28447" checksum="CC5C2F72EE750845" modified="2018-10-10" version="1">MVGIGAKITRLLPLIGYHHVLMIIIAVAIILLSLLLAGCSSSSPQIPDIFLISLYYERYKPTFNLAQVDPGVVTATANIVGGAQMEVRVGYFGICVQPDDGSYICNSNATALAEIVTVDQDPLNLIWVASTFKDAVVFPYLLIIAVILAFFCFILLATFPGWHDELDPSGSEVESKPFPSRPVSQAALALIFVASVFVLVSVLWQHTASVAASTIAQDMGNGSVKSGVGTSAMVLGWFGFGLLVVVTIGLLVMILSINLIKQLTDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WRS7</accession>
    <name>A0A317WRS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_492004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY88012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467795.1">
        <property type="nucleotide sequence ID" value="XM_025609172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WRS7"/>
    <dbReference type="STRING" id="1450535.A0A317WRS7"/>
    <dbReference type="GeneID" id="37111315"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000106">
        <property type="entry name" value="Glycosyl hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="65"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="640"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY88012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="762" mass="86422" checksum="53CE744FCF279076" modified="2018-10-10" version="1">MGSLRLRIDGRTFKDPQNREITLRGINVAGESKYPKNPDTPSYVSDAFFDADNVSFVGRPFTLDDAHTHFARLRKWGYNTLRYIFTWEAIEHEGPGKYDDEWISFTIEVLRVAKQYQFYVFLDPHQDVWSRLSGGSGAPAWTLYAAGLNPRAFKKTEAALVQNTYDNPAEFPKMIWSTNYTRLVCQTIFTLFWGGRDFAPKAIINGVNIQDYLQGHFIAACKYFAQKIHEAGDIENDVVIGWESMNEPHRGLIGVQDISVIPPEQQLQLGTSPTAFQAMLTGSGRACEQTTWAFGSFGPHQTGRELVDPEGESAWLPADYDDQKYGWKRDPNWKLGECLWAQHGVWDPSSDQLLRKDYFAKRPQTGEPLDYDKFTNSYFLEHYRAYRDALRSVWPGAIMLCQPPVMEIPPDLKGTIDDDPNMVHAVHYYDGLTLLTKHWNRLYNVDVIGVLRGKYLTPAFAVKIGESAIRNCLRDQLKFLRDESLRYMGNHPLVFTEIGIPYDMDDKYAYKTGNYSSQVSAMDANHFALEGSTGNGFTLWLYTTTNNHEWGDNWNGEDLSIYSLDDLELPSGKLLALEGESRSDPNPHSPAYSESQGDAEIQRVGPENLKNALPPPSITSEYTQSNADKLGFRAGEAFIRPSPIYTHGLISKYLFDLRNCTFTLSLVGKERTVGDETATEIYLPEFHFPDSQTVVSVSSGEWSIDYTEINSIKVQRLRWWHMEGDQDIKIQGVKRKPGDMSAVSGDDLSYLEQCQTGGCEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTJ2</accession>
    <name>A0A317WTJ2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_574597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468577.1">
        <property type="nucleotide sequence ID" value="XM_025615027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTJ2"/>
    <dbReference type="STRING" id="1450535.A0A317WTJ2"/>
    <dbReference type="GeneID" id="37117170"/>
    <dbReference type="OrthoDB" id="4218955at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00306">
        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="4">
        <location>
            <begin position="59"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY89666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="182" mass="20048" checksum="E8D14E9B179F2DC1" modified="2018-10-10" version="1">MTDAMAEQSSIDQEIERLVSIGNDRSVYRLAQSTPADSYALAKKLPVMSEGAPEPMKAALLDSGIELSTADKNANSREPTIVFKDWVKPDNTAWRDDNGHGTHLAAIFRKVAPHAALYVARVYDQPINIDTSEDRIAEAIMHATDEWNVNMIIMPWGYTSSPSGRSRIAEALRHAKSKGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTR7</accession>
    <name>A0A317WTR7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_37821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468396.1">
        <property type="nucleotide sequence ID" value="XM_025607239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTR7"/>
    <dbReference type="GeneID" id="37109382"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY89485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="165" mass="18569" checksum="92074A0E732E83A9" modified="2018-10-10" version="1">MQMPIIPAATVILECGLLHRAYIVRRIQTPTPLMLLTSVAEGLNLHPKHQSAVYLTSVLSPSPALLLTRLGLDPDVCTLSTWPLSICDPFFPTLFSFLSIQSSLHYHCEPDCDDVSCSTHQSAWCMFNSPCLTDNIQSRVYTASFAFFEALWEVRWKRMILLAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUC6</accession>
    <name>A0A317WUC6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">NADH-cytochrome b5 reductase</fullName>
            <ecNumber evidence="20">1.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BO94DRAFT_545426</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71231"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:71232"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 20">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19 20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="20"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468342.1">
        <property type="nucleotide sequence ID" value="XM_025613236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUC6"/>
    <dbReference type="STRING" id="1450535.A0A317WUC6"/>
    <dbReference type="GeneID" id="37115379"/>
    <dbReference type="OrthoDB" id="432685at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000019">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF184">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19 20" id="KW-0274">FAD</keyword>
    <keyword evidence="5 19 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12 20" id="KW-0520">NAD</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="21">
        <location>
            <begin position="58"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="PWY89431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="307" mass="33664" checksum="333929CA6686B992" modified="2018-10-10" version="1">MSTFSPENITGAFIPSALFIAGTFLFKQELTPFAVALAAVLVGYKLFSNKPRKVLNPGEFQHFTLKEKNEISHNVTIYRFALPRPTDILGLPIGQHISLAATIEGQPKEVVRSYTPISSDNEAGYFDLLVKAYPQGNISKYLTTLQVGQTMKVRGPKGAMVYTPNMCRHIGMIAGGTGITPMLQVVKAIIRNRPRNGGNDTTQVDLIFANVNPDDILLKEELEALAKDDDGFRIYYVLNNPPEGWTGGVGFVTPDMIKERLPAPASDIKILLCGPPPMVSAMKKATESLGYTKARPVSKLEDQVFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WV74</accession>
    <name>A0A317WV74_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA thioesterase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_545822</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468100.1">
        <property type="nucleotide sequence ID" value="XM_025613260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WV74"/>
    <dbReference type="STRING" id="1450535.A0A317WV74"/>
    <dbReference type="GeneID" id="37115403"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000074">
        <property type="entry name" value="Acyl-CoA thioesterase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="4">
        <location>
            <begin position="42"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="5">
        <location>
            <begin position="175"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY88738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="376" mass="41437" checksum="9C347FC66BAF1296" modified="2018-10-10" version="1">MANSATLFKPPPLDSAKAPIENVLDLTPVVDVGNDVFTNTRPLWHPPGARGIYGGAAIAQSLAAAMRTVPADFAVHSMHCYFLLAGDSEIPILYHVERVRDGRSFITRTVQAKQRGRPIFTTTLSFSKANSGGKKKLEHASSMPPVTLPQEPGSGSNQRIVKSGGGPFESQKAGVVDPYSPGFTLTVTDNLPPQEKKTRRFMRSRGRISDAGGHHAHLSALAYMTDSYFIGTVVRVHDVPRFSSPAELKKALNALKNPSDLDDEDIARALKELKEEEATDLRRRLEGALHRVTNQPPQERKEVGMLVSLDHSIHFHNPWAFRADEWMITEMESPWAGEGRGLVLQKIWSKDGTLIATCTQEGVVRLKQDEPPRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVA6</accession>
    <name>A0A317WVA6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phenol monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_514066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468674.1">
        <property type="nucleotide sequence ID" value="XM_025609873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVA6"/>
    <dbReference type="STRING" id="1450535.A0A317WVA6"/>
    <dbReference type="GeneID" id="37112016"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02979">
        <property type="entry name" value="PHOX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF15">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="42"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="365"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="6">
        <location>
            <begin position="476"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY90296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="655" mass="72647" checksum="2529EB9E496EB337" modified="2018-10-10" version="1">MPVFTEFSSKSRDLRVLPSFALPLPRLTPPFQPTGNDGVERYEVVVVGAGPAGLMTQLLLARYGLSDDSLLCIDSKANTLKSGQADGVQPRTLEVFKTLGISDEIENEACQMWQFAFWNTSTDTSKTIERKSVVSNVIPPARFCYEATMHQGRIERIMETDLLRYSKRGVQRDTKLLHVQIDENDPEFPVLAAIETRDVRRVIRTKHLVGADGAHSTVRKCMGLRLEGQSLDHIWGVVDMVVDTNFPDIRRRCAIHSPAGSVMVIPRERIVTGEHLTRLYVQVPGLAKPESDVTPGGAPPELNVEDARIRRGQVTLEGILKQASDAFEPYHLRPKNGLIDWWAAYQIGQRVSPDFIAKDSAGVPRVFIVGDACHTHSPKAGQGMNVSMMDSYNLAWKLAYHIHGLSAASVEQGTPDPLLDTYHLERHANAQQLIDFDRQFSTIFSGQLDTGESGMSHAQFVETFNTGNGFTSGCGVEYPENMIVVREPSASPVHGDDYLSGILRPGRRLLNVKLRRHADGRHRDIQDDLASNGRFRVLTLTSDDLLNAQGVSARALHNVAALLGEFPAEVIEQIVVHPRLPSDFEWNNIPACVKEQAEMRFYNGHDLEDTYAIYGVDPGQGALVVVRPDGYVGMVAQLCNVGHVKEYLSRCIKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW52</accession>
    <name>A0A317WW52_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2OG-Fe(II) oxygenase family oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_534081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468967.1">
        <property type="nucleotide sequence ID" value="XM_025611455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW52"/>
    <dbReference type="STRING" id="1450535.A0A317WW52"/>
    <dbReference type="GeneID" id="37113598"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND FE-DEPENDENT OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="225" mass="26433" checksum="05E4FB4937FE6E7B" modified="2018-10-10" version="1">MQELPISPRGILWQEDFITPEHEQQLISIFRHELDWPDRTGRQSLHYGYTFDYKTFGIDPDIPYKEFPDWLKPLIPTTENRPPEQVCLQYYPPGSGIPPHVDAHMAYDQLYALSMGAPVMMQFRKGKTEERVDVDLTPRTMMQMRGDARLHWTHGIKKRKTDTLADGSVRVREDRWSITYRWLREGECECGNLELCDVAQRRNGVEKEKRSLKELAEKKLLEEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWS0</accession>
    <name>A0A317WWS0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_534409</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468548.1">
        <property type="nucleotide sequence ID" value="XM_025611544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWS0"/>
    <dbReference type="STRING" id="1450535.A0A317WWS0"/>
    <dbReference type="GeneID" id="37113687"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000082">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5 13" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="9"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="170"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY89637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="424" mass="46148" checksum="108ADB25854AD325" modified="2018-10-10" version="1">MKREDITYLGAGPASLPTDVLATAAQALQNYQDTGLGVAEHSHRSEIAANILNSAKADLANFLDIPSTYEILFLQGGGSGQFDATVYNLVAVWVEKQRQLIVKQRGEISEQEVLSELRKKVESDLRLDYLVTGSWSLKASQEAIRLLGPEYVNIASDARTVNDGKFGKIADESTWKLSRKAAMVYKCENETVDGVEYPSFPKVLEPKGTDEDPIVIGDYSSTILSRRIPVENYSIIFFGAQKNLGVAGITGVIIKKDLLPPVSPSASPAILRKLGLPIAPTILDYSVAAKNNSLYNTLPIFDVYIAGQVLKKLLATFPDKVDGQQAVADRKAKLLYETLDAYPEVYKVVPDKAVRSRMNACFRVVKGGNVDDTEKAFLKGAVERGLTGLKGHRSVGGIRASNYNAVPESGIEKLAAYLKEFATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WXX9</accession>
    <name>A0A317WXX9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_594450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468559.1">
        <property type="nucleotide sequence ID" value="XM_025616199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WXX9"/>
    <dbReference type="STRING" id="1450535.A0A317WXX9"/>
    <dbReference type="GeneID" id="37118342"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="46"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="298"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY89648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="369" mass="40494" checksum="8AAC03726D78C44B" modified="2018-10-10" version="1">MNDTIIPAMAPPSGLVSNFVDPPDCGTKFIVVNCVFLPVAVVALGVRMWTRLFVVRSVAWDDYLMVLAVVYSVGGAFGVTLDMLKYGLGKHMWDVPLHQVTPPFLKYNVVAAIVYCAGTGFTKVSVLIFYLRIFPSRGFHLAVWTIVFIAVGYNVASVLANVFSCTPVAGAWDLSIKSTCMNRPVFYFANAGLGIFTDFATVLVPIPWLRRLQMPLRQKIAIGFMLAMGCFVGIVSCIRLASLYVLLKSTDLTWATTNALLWCTVELNLGITGGCITAMRPFVRRYFPRLLGLSSNGYGQSSSRKYGHPLNSIPRDQPDFGNRSQYSTRLKGGTGGSAEHILPARKDDDGIIRTVEFNVDTRGGRESMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WY57</accession>
    <name>A0A317WY57_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Agmatinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_573805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the arginase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469084.1">
        <property type="nucleotide sequence ID" value="XM_025614987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WY57"/>
    <dbReference type="STRING" id="1450535.A0A317WY57"/>
    <dbReference type="GeneID" id="37117130"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF28">
        <property type="entry name" value="HYPOTHETICAL ARGINASE FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036979">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016295986" evidence="6">
        <location>
            <begin position="22"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR036979-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY91356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="405" mass="43609" checksum="6660C4F8DE4B9F6B" modified="2018-10-10" version="1">MSAIMYPLILSLALLVLPARTRDIVFPPVAAIHNPSYQYPLAHEDTIDIVTGSQFSGLTTFANLPYVNCFIDDDSTFNNYDIAFLGAPFDTGVTARPGARFGPKGIRLGSRRLGGWSIYTGENVFASWAKLVDCGDAPLTWLDNTVALKQLDLAHKVVSSRRANATHLSQSPRIITLGGDHTTTLSALRSTYENWGPVSVIHFDSHIDTWDPEVLGGGVSHYAGINHGTFLHLAHEEGLIRNTSIHVGIRAPVIRPKGDLRNDLRCGFEIITARALDRLGVSALVEQIKSRVGETKVYISVDIDVLDPAYAPGATSPLYSGLYMPHQRLMTLTVGMIATGTAEPGGFTTRELLTILDALRGLPVIGADVVEVAPIYDTAGETTTLAAAEVAQSLLALMVARPVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYB5</accession>
    <name>A0A317WYB5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">D-mandelate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_513323</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469077.1">
        <property type="nucleotide sequence ID" value="XM_025609840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYB5"/>
    <dbReference type="STRING" id="1450535.A0A317WYB5"/>
    <dbReference type="GeneID" id="37111983"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000526">
        <property type="entry name" value="D-mandelate dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="4">
        <location>
            <begin position="70"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="5">
        <location>
            <begin position="125"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY91349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42623" checksum="68BEB4F65932EAC8" modified="2018-10-10" version="1">MKPKILHIGDPIKYNHDIYARFTTEFDLIRPPTADRQRNAFKQALKDRRWGDFDAIFRPFWNTGGEMGRWDEELISLLPASVKIIASAGAGYDWVDVDVLARYGILYCNGAAASSESVADMTLFLILSVFRNLRWSHSAAHSLNAGQFLDAHTNSPLTARNPSTQTLGIIGLGQIGYTIARKVHAAFNMRILYHDLIRKDSKLEDAVNATFVDSLEGLLGQVDCVVVSTPFAGRTLMSREMFGKMKRGARFINVARGGLVDEEALVEAVENGQVSAVGMDVHANEPDVHPRLAASGKVMMMSHNAGGTVDTHVGFERLAMENIEGFLLRGVAVTPVNGHLITTTTTTTTTTTTTRSKNGGKEGGVSCDEVRVRIYMSFSKYSTYTREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYP4</accession>
    <name>A0A317WYP4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mcm2 3 5 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468765.1">
        <property type="nucleotide sequence ID" value="XM_025611412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYP4"/>
    <dbReference type="STRING" id="1450535.A0A317WYP4"/>
    <dbReference type="GeneID" id="37113555"/>
    <dbReference type="OrthoDB" id="4721035at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="644"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="80278" checksum="821217FB4E07951F" modified="2018-10-10" version="1">MAESSDNLRLLPAGKPPETCSIEISSGDDKSDFCLQDLGTNRDSFRSSLASTLPKAVDHDDQPDDVPVPTTKPKRRCSLVFTTLIVLAVYTTIFSGIFFVIACVKPFYGRLIGSNASLNASTASLLSALIAKTIELSYVTVCVAFLGQLLSRRALAHGSEGVSIADMTLRTWITQPGSLLMQWETLRYVGWTTLGALTLIVALVAMLYTTAAEALVSPNLVMGPVQHRLLQGNVSTQYSNPYYLEDECQTPITSAIDPTNWNSTCLAMEMAGRAYHDFYQYLQGWAELLEDGNSTSSVLAYRPQPNALLYDNTTVKGRWIETDNMTQVSQQYGRMVNNITAAYPHGGLFAAARDPANRIQQPSDLSGEGKYILSASVPSPAVNILCAGITHDELTPLIYTEWPTHDPFNASTWYTSAPTYSTTNTTAIDSLFGFSSSLPAPVFPIYPQPYNTIINPKVPNTTSIYVLGTAPTSHNPPYVLCGIRGKLSGRCSARYAVDSSGGELTSHCEDPADTLQYSRLHPDTSESEYNMNWKSVAWEWADSVTLGSGIMGDDASIERLLMEMIPPFDSSTNTSTLDPTMPSLSEALVVLTGTTLLLGSQDSPYVPYWNYTTSSLSTPAVQVFNATLQSAGYASGRTSDWQQVFYVILAVVFVTSIVCLGFILLQVRGHLVTDFTEPPNLFALAVNSPGGGQWTGTPTGREAVPKLRERWHVGVREESGHYFIRTRARMERDVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WYW6</accession>
    <name>A0A317WYW6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_462603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469304.1">
        <property type="nucleotide sequence ID" value="XM_025607982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WYW6"/>
    <dbReference type="STRING" id="1450535.A0A317WYW6"/>
    <dbReference type="GeneID" id="37110125"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY91576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="683" mass="76498" checksum="464F3B21C50F9035" modified="2018-10-10" version="1">MPREKVKRGRRAADKASKRKRDDAPEDDVPKRLKPSTDETNDIVEGADYIPMDGDVGQEDQEGAPVGDMPFYGLLDPEEQEYFSRANEVLETNQFGDAEERRVFVDSVYKEAEGKELKIACSQSCSRLMEKLISMSDMRQIRRLFSKFIGHFLHLVQHRFASHCCETLFIHAAPGVTQKVSKSKRNHEEDEEGDEPEPDLSLAEMFMKVIEELEGNWGYLLTERFASHTIRVLLLVLAGEPVDLSLSDSIVASRKKERHGVLSTDAQEENPVAQKRSVPESFEGTLKKVMQDMVSVLDDTYLRALATHPVGNPVLQVLVYLELSHFGKSSAKDAKSIIRRLIPDDEFAEGTESTVFVRGLLYDPVGSRLLETIVRCMPGKLFKGLYKNFMRDQLRSLARNITAGYVVLRVLERLGKDDLQNAVELLVPQIPNLVERSRVIVPKTLIERCIVRGVDTAPIARVLETAYDSDPAKRLNQMLGLDGAQEDAEGQEHKPSELGPDANQKGAKLHNSLFLQTMLTAPGPLSGLVYSSLLAQSPESLVTLAKDSTTSHVIQKAIALPTSTSQFRRQFAVRFTGHLEELALDSSGSRVVDALWPATKDLFFVKERMAQELTQHEMALRDSFVGRAVWRNWALDLYKRRRGEWAAKAKGLDTGEKPKSRLELAREKFAAKAAESAKNADNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ02</accession>
    <name>A0A317WZ02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Homoserine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_533722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469311.1">
        <property type="nucleotide sequence ID" value="XM_025611384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ02"/>
    <dbReference type="STRING" id="1450535.A0A317WZ02"/>
    <dbReference type="GeneID" id="37113527"/>
    <dbReference type="OrthoDB" id="444135at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000099">
        <property type="entry name" value="Homoserine O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001209">
        <property type="entry name" value="PRK00175.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF16">
        <property type="entry name" value="SERINE O-SUCCINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="140"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY91583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="528" mass="57635" checksum="EA41CFC844516E8C" modified="2018-10-10" version="1">MGPSGIARSAPRALKAATRLNQRESLSTLGGGRRIQIPSSTSYPAQAHSRALHHVPSRRSQSATASNPAMSFPCLDAQDAKSAQLSARSLQSGPEPSYTTGHHEQFHCEQPLLLDWGGVLPEFDVAYETWGQLNPDKGNAILLHTGLSASSHAHSTEANPKPGWWEKFIGPGKPLDTDKYYIICTNVIGGCYGSTGPSSIDPSDGKRYATRFPILTIDDMVRAQFRLLDSLDIDKLYASVGSSMGGMQSLAAGVLFPERIGKIVSISGCARSHPYSIAMRHTQRQVLMMDPKWARGFYYDSIPPHSGMKLAREIATVTYRSGPEWENRFGRKRADPSKQPALCPDFLIETYLDHAGEKFCLEYDPNSLLYVSKAMDLFDLGYDHQSETQKRRAGYEAKIAEGGKTLQKSDIACSLTLPEKPYEEQPSVTAGTPSMDQAVGGEAGPDAPPRDLVAGLAPLKNHPVLVMGVASDILFPAWQQREIAQTLRAAGNENVEHIELGEDVSLFGHDTFLLDLKNIGGAVEKFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ37</accession>
    <name>A0A317WZ37_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inhibitor I9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_623492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468401.1">
        <property type="nucleotide sequence ID" value="XM_025617156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ37"/>
    <dbReference type="GeneID" id="37119299"/>
    <dbReference type="OrthoDB" id="5518345at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7766" checksum="CA5AEDCB36F27CFF" modified="2018-10-10" version="1">MPRYTITARDNTPASELETAKQHAIDKGKLVAELFTLKGGFIVDYPDQIKAAEVHSNLHVEQDHTFKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZC3</accession>
    <name>A0A317WZC3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_594299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468491.1">
        <property type="nucleotide sequence ID" value="XM_025616196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZC3"/>
    <dbReference type="STRING" id="1450535.A0A317WZC3"/>
    <dbReference type="GeneID" id="37118339"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016190361" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY89580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="503" mass="54331" checksum="202A6DC04E064D96" modified="2018-10-10" version="1">MVVFARTLLALSAIQVEISSASRCSSAAIEKPDLVGASILDIQAQEAHNFSAVSLGPGNNEGGRYTISFCNITVTHTHPGWNDTVHTQVRLPLEGWNGRFQGLGGGGYSTGFGATYMTYAVAQGFASASTDGGLTTADGSSTIPTDLSWALISKGNVDWPLLHNYATKATNDMAVIGQQITKSYYQKPANYSYFAGCSGGGRQALMMAQQYPDVFDGILAVAPAINLQTFIPAGYWPSRIMHETDVYPSPCEINAFTEAAVKICDRLDGVEDGIISDPDRCYINATHFVIEAAWSGSRSVSEQYGWFGVNKDADISSYYISTTCSANSTCSSARSDLFGNWFKYLVAKDSTFATNNMTEKQFFDAMHSSLLEYTSLVGNTDPDLSSFKASGGKLITWHGLADEVIPPKGTVSYYEEVLKADPDARDYHRFFEALGVAHCYGGPGPVPNGAMSQLVEWVENDQAPAVLHATRGSNNTARDLCPYPLRQTYIGGDFRNATSFTCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZD7</accession>
    <name>A0A317WZD7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_378674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469474.1">
        <property type="nucleotide sequence ID" value="XM_025607243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZD7"/>
    <dbReference type="STRING" id="1450535.A0A317WZD7"/>
    <dbReference type="GeneID" id="37109386"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="2">
        <location>
            <begin position="79"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="320"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY91746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="511" mass="56764" checksum="15DF1615D68642C3" modified="2018-10-10" version="1">MHDEPTAVLQQLEKEISGALLTGAQGIRFLWVTLQLESISDTERVKDIDSIRKALTSLPPKLSQSYEVIYKRIQSMGEGPRTVAVQSLQWLSCAKRKLSVSGFFAVFSRSSVNSTTVSARCVLDYCCNLVAIDTLADTFRFAHATVREFLETLADYSVHEASTTVSKRCLSTYLWGEYCEDGLLDYATSYWPAHVEQLSVSCQKSGVQKLVTKFFTEEEHLEDWLEHLDERLIEDGFRWSNSLERKLEACFASPPSVLFTVSCFGLFEVLDSPEVIAMIDVNQNNRHDTSGLYLAARWGHVEVVRKLLHLEADVNAPAYQYGSPLQAASFSGHEEIVKTLLDHGATFSPSEKGEYSSPLYAALANGHESIADILLDGGLKFFTQRQFTDALDTASFKGSTKVVERLLNGTAGGFTPNIRPDPLQVTLFGGKTRQAKRLLQECIDVTEERDTLAMPSLPPSLFINLPLRSYLLMPVQNSTLVDVLGSLCGLPQLPINLRSRGTFLGKVLILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X1A9</accession>
    <name>A0A317X1A9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_22553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468698.1">
        <property type="nucleotide sequence ID" value="XM_025606255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X1A9"/>
    <dbReference type="GeneID" id="37108398"/>
    <dbReference type="OrthoDB" id="449382at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="1">
        <location>
            <begin position="144"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="278" mass="30532" checksum="82CF9D9D859C72DE" modified="2018-10-10" version="1">MSCYEVFPSNDLPYPIHSKLPVISDIDGLSNFRDVGGYPVAGGGSIRKGMLFRSSNLDDITQSGAQKLQTRHGVQAIFDLRSGGEIVESSRYLSAIPVTHVPALADFDDDQIVAYLKGLATDDTSAVTAELYLWICAMSTVAFRAVFTYLRDHPGCPVLIHCELGKDRTGICMAIILLVLEASDQDITRDYQLSEQGIKGMIPGRRLKLSELPLLVDSAVPPVALDRHFLVSSDTMRRFLMRFRQTYGSGEGYLQAIGFSCVDCDVIRSNLVAHPVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2V1</accession>
    <name>A0A317X2V1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 zinc finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_564644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469680.1">
        <property type="nucleotide sequence ID" value="XM_025614440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2V1"/>
    <dbReference type="STRING" id="1450535.A0A317X2V1"/>
    <dbReference type="GeneID" id="37116583"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY91952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="709" mass="79374" checksum="CF5D9DF16DF7FA1F" modified="2018-10-10" version="1">MNPLSEPTDQAGTAPSSPSVNKPKVRLSCETCRQRKVKCDKLNPCTNCQRLGARCVPVERARLPRGRSGRLATERPGDQDANLKDRVSKLESIIRDLARGGSQASVRAILAAAVEESSQDGENSLGEDDSQAGGVRRPDTYLGSSFWANLLNEVPDVHPNERRSSKSDDRNAETNNLINYRRLLTMASGSGGTTNSEPPGTSSTHQQLCCLFMQRVDPICKILHRPSLKAFLVDGSPYLDYEPGHLAPTALAYSVYYAASCSLSDEESIRSFGVPKSTMVSRYQKEAEAALARADFITTNDLTVLQAYVLFLIALRSQDQSRRMWTMLSMALRIGQALSLHLPDPPFHVRPFERELRRRLWLAIGFLDIQASMDRASEPMMQASWLESHPPANVNDIDLSPNMEANPPDSPGFTDMTFTMMVHKTQYVARSLNFSGFMEPSITTLAIRQQLVLEFQQSVTKLLQHAEPDKHPFHWITRAIAECIHACMQLITLRPLQRSPNFTPPLVRGDRLLEFAVNVLIVSRRLRSDPRFTTYQWFEFAFPPWHCLAVALAELCVCDDKAVMERFWDPIEESFHLLGRLIADSQRGMLWKPMEKLMARARDRRVQLLASPSPDAYSPSLSTAVQQQPISMQMDTQGFVPGIDGRVGLQHAVAAMNTPESVVDGTWPNVWDAVDFSYAAPGTAQVAWMSYENFVADFYVNVDDPLVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X332</accession>
    <name>A0A317X332_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_554560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469724.1">
        <property type="nucleotide sequence ID" value="XM_025613726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X332"/>
    <dbReference type="GeneID" id="37115869"/>
    <dbReference type="OrthoDB" id="4493271at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY92963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="476" mass="53132" checksum="7D70A4551E729311" modified="2018-10-10" version="1">MEASLHQALPRSESSSDTEKPPRTRTWLRPLKRLFSLFIPRKTIKRRQIFRRRKKPNERNNPPELVVPRRQVGDPTNGRLPTADGHRKPDEPKEEDNEPASHPAMETSNDPEGTLTHEHFERNGVDISSLATGGRFYRSVSSGTSTVSPGVYSPASPPPDVISTESTTPLDKIEEIGLPSDDQESRNPSLENRSQEALSSVSTNSDQYYIELVLVVANDNRHKVPALMALDTQASANVMSVALWRKLGMRLESCSQELIPLQSGSGNVVRIETYGRVREVAWHVAGGERTHVCDFLVADLRDHDVILGKRYIHRKKILTWGPDEITVSLKAVVAEDMDVSILTQSGFRALPGIQVQPQETERTFYDSNGVSYAVRDVVQLPIWKKGEAKLTTQDFYVSTDDSSGLRPPCHAILGSQCLVGKVSDEKGVPIAVTQLPSQSASDKAIQEQKKREKEAALAKKEQERRDREKQQAAQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X425</accession>
    <name>A0A317X425_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycerol kinase</fullName>
            <ecNumber evidence="4">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_459635</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470145.1">
        <property type="nucleotide sequence ID" value="XM_025607849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X425"/>
    <dbReference type="STRING" id="1450535.A0A317X425"/>
    <dbReference type="GeneID" id="37109992"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="7 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="12">
        <location>
            <begin position="53"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="13">
        <location>
            <begin position="317"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY93384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="570" mass="62999" checksum="8F207A67B6245884" modified="2018-10-10" version="1">MRNPFDMTDLDAVVEQEEAKSYMDIHAYQSHDGNRSLLQNENRHGGSLKDRFIGAIDTGTTSSRFIIFDCTGVPVAKYQMEFRQIHEHSGWHEQDPFELVDSVYTCIEEAMKTFLALGHSRDDIEAIGITSQRETTLCWDWETGEPLHNAIAWPDTRTTGLVRELKAKKGADELSNICGLPLSTYPSSVTLVWMLRNLPEVKRAYDEGRLAFGTVDTWLLYNLNGGPEGGRLVTDVTNASRTMFMNLETLDYDDRLLNFFEIDRNKIKLPEIIPSSDPEGYGWVRDGPLEGIPITSCLGDQSAALVGHCAFTPGSAKNTYGTGCFLLYNVGDKPVISKHGLLGTVAFQLGKHRKPVYALEGSVAVAGSGISFLMNNMGFFRDSRKVSDLAASVPDSGGCYFVTAFSGLFAPYWIDDAKGTIFGITQHTQRGHIARATMEAACFQTKAILDAMEMDSGHKLSELAVDGGMSNSDICMQTQADVIQIPVDRPAMHETTALGAAIAAGFAANIWQEFEELKDMNRANRTTFLPHASPVQSKKMYRQWTKAVEMSRGWIDTNEMDGEENGENGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X444</accession>
    <name>A0A317X444_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nuclear migration protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_583562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470097.1">
        <property type="nucleotide sequence ID" value="XM_025615570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X444"/>
    <dbReference type="STRING" id="1450535.A0A317X444"/>
    <dbReference type="GeneID" id="37117713"/>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF2">
        <property type="entry name" value="MIGRATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="3">
        <location>
            <begin position="914"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="587"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="712"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="761"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="855"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1263" mass="138392" checksum="C312252026BFB732" modified="2018-10-10" version="1">MATNTLYSSPPAARAFPTPSTTPQRPPSIHVRADSSPGLSSSSNSLPILNFSPDGRSEYDDTAEEDNLSPLDPRRFTPTLHASLVSEILSLRRDVESKSKAIDILERSLDESRTENEDLSERLSKSTKETRSFKHQLQLLEGGASSALTELARERDEALENIADVRKKLEQAQKKARSREEDVERTVQLWDRDKDAWEGERRSLERKVHVVEGRLKVVLKEVVAAQAVGSFQPLQDVDGMEIELTRKSAAGKDSDSASVDSSSQGHRRTSVTSVNADSGDEADYHNVRYSMASVANVPGLKSEGLSLAQELAFDEEDEFESFDTDFVPESPEALPEERPASVHSQLSRTMSMGAKARKILGLSLGSADGYGFKTEGNSEPGSPLKISSTTFVYRDTGIQYSPPPSPLSPSKSEPPSCDQAAECPSSEEETSFYQRKDSSTSTLTPTLTIDMVSASCQTIEDLPTPPWTPKIDEIPQPAPEETAMVSVSVQTIQAPVAETDDKRVNASPTDMESSELEIPMIAIHPPCSEPPSPRGSVVLPPQTKSVSCQVNFSPSIDSRTVGIQTDEIRIDQRPVKLPASLLPSAIPDLPLRESTQDDPIQPYRIPPPRSRKRENRASSHTKPPEPVQAYPGNNDNGPLSEESKSELRRPLRSSSLFAGFDQASDEETSGQTKDIFTDDELLNRPFASYTLKRGKLVSTHDATLPEIDEHLRESEVHSSETPTDQGPKEVVGTSSWTQRLGFGAPGARQQDMCKSAMISNGAAAHQNMRTRSPSEPSMESGGGASGIAPPIPVPMRFSSRKFPSGNDGRQSPTPSNPRNFSDRARPPIIRRPTLRRVRSAAAMSHIEQHDRPDSRSSPTMSSSSCGPDSPQHPPLPFDKITAPSGKRAVERRTSAHPFAHGRHDSTATTVQPTSVVDAIAQTMVGEWMYKYIRRRRSFGGVGESKDSWEGRNADEVSANIANSGARHKRWVWLAPYERAVMWSSKQPTSGPALLGKSGRKLIIQSVLDVKDDNPLPKGFNPQNQFNRSILILTPQRALKFTASSIERHYVWLTALSFLSHSSMGLHDLDTLPPVPQEEYTNPAPTATLRRNPIRDSIRIAKGRPRPRPKGKRSLLGQPEPVPELPSGPPTVPRFSNHARKRSNTAPRVPIIRSFSSQGTMPSVASTRGSSDTYGPALYGQGLTSSVGSVSRRTSEASVGTSNFFDAIGTVRMEAFIDQTNGYKGTRSERHSRKASSAWSSNQELDSPYEEGGYFHRDDPFGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4P4</accession>
    <name>A0A317X4P4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_554814</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470066.1">
        <property type="nucleotide sequence ID" value="XM_025613744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4P4"/>
    <dbReference type="STRING" id="1450535.A0A317X4P4"/>
    <dbReference type="GeneID" id="37115887"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY93305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="483" mass="53002" checksum="83EB0CDC035D99CD" modified="2018-10-10" version="1">MAVWYAFGVAIFSAIGTFLFGFDTGIATTTIAHQSWINYMKNPSNGLTGAVVSVYIAGEAVGALTQTALGDKLGRLRFMELLCVMVTIGTIIQTAAVNIGMFLAGRALAGYAVGGLVATVPIYLSEISDPRYRGLIGGISGCGIAFGTMASNWVGYACSFAPYGPVQWRLPLGLQIPWGIVMFFGLITFMPDSPRHLIRKGNVEQARAESKKIRRDLRADEFQEEFAAMVAQIQYEKEREISSYKDIFRLFRRRALVSIAVQTMTSLTGVNVIQSTLYKSLGIDSHTILALAAVYGTVAFIFNCLTTKYLTDQWGRRKMLLSGLAGIIIIEIYAAVMQREFQNTNNRVGKGFAILGIYLFVVAYYGMLNSTTWLYGAEVLPIAIRSKVMGLAAASHFIVNVAITEAGPSAFANIGENYYYVFVACTIFFLVVAYLYFPETKQRTLEEIAASFGDKVIVTGERGDSEDPDAKCDSQRIEVVHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4R5</accession>
    <name>A0A317X4R5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BO94DRAFT_533697</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469278.1">
        <property type="nucleotide sequence ID" value="XM_025611377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4R5"/>
    <dbReference type="STRING" id="1450535.A0A317X4R5"/>
    <dbReference type="GeneID" id="37113520"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="7"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="180"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="PWY91550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="417" mass="47009" checksum="A3D2C363C68381D8" modified="2018-10-10" version="1">MASEKPRVCLAYSGGLDTSCILRWLIEEGYDVVCFLANVGQEEDWAAVEAKALQIGAKKMIIEDLRREFITELCFPAIQCNAIYEGRYLLGTSLARPVIARAQMRAAQRENCQFVSHGATGKGNDQVRFELAFYAIQPSIKVIAPWRDPKFFKRFAGRNDLLDYAAQTGIPVTSTKAKPWSMDSNSAHCSYEAGVLEDPNHTPPSDMWTMTADPMTAPDEPTDLTIHFEQGVPTKLITPGKEYTDPVELFYTLNKIGFTHGVGRIDIVENRFIGLKSRGCYDSPAMTILRDAHLDLEGLVLDGQVRALRDQFVTHNWSIQLYNGYYFSPEREFIENSLKFSQRRVNGEVRLRCYKGHVYVLGRSSSTEKLYSEQEASMDSLEDFEPTDTTGFVAIQTIRLKKYGLQKAEEGESLSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4U4</accession>
    <name>A0A317X4U4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_533097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470116.1">
        <property type="nucleotide sequence ID" value="XM_025611264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4U4"/>
    <dbReference type="GeneID" id="37113407"/>
    <dbReference type="OrthoDB" id="3926209at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF3">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33220" checksum="6A749CED845DEFB4" modified="2018-10-10" version="1">MDAPQVQVGAPEGPSNGSNAEKENVQTSQNTTSFDLNASAASSAVNEGQADSSHDIVLPDASAADPEPKPAAPKRNPGLQFLDYLRSPIVELVVGTGETKTTLTAHQSLLLASPVLAEKVTTFEGSDPRRIDLPEENVEAFGHFLQFQYTRDYSASQSDSHTEQEAVVGEIDDSGEQLLKHARVYTLAERLGIPSLKTLAHSKIHRINSTSHGEIAYARYVYMNTPVDDVTIRKPVATFWALRSHVLRHEAEEEFRKLCIEVPQFSFDVLSLVLDQKEKRAQDKAESESAVKGSGRKRLRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4W1</accession>
    <name>A0A317X4W1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_347308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470367.1">
        <property type="nucleotide sequence ID" value="XM_025607082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4W1"/>
    <dbReference type="GeneID" id="37109225"/>
    <dbReference type="OrthoDB" id="5421971at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="472" mass="52540" checksum="7AB7603EE71B7F9D" modified="2018-10-10" version="1">MMRSRDPRVRQTINQIHHNLESANETAQEGLYAFSHNYLVPCFAAIGSCVYSCTAPCLPTREDHLRRRRRGRAEANFDFYDDWDNEESNDGLLGWGTDELDRLLAGSGLTRGSSEQPRRQRKMSYGARRIRRKSSVIVSDDRNDPTVIPSSSFLGFLERFPWRFGARGLKYRPSAADLQEHPAGLRRFEHEDEPLIEEPEENEGPAASVRNGRYRSSTQSSRDTTNSLSSRGDLIPSDEEEDAVPLDDEFALALASRRGTGLDSIDLIGDKPASMRSVSGTFSLRTTASSKETKMKNKKRSSRLRSPHGSYVEVTHEVGTPTLADLKKEEERAALEEESEIARRRLAAQQLASNRGLDQAKDEALPSQPHTVSSDVAHHETVDTPLDPTVEDSPTKIQGVQSQPSLNSRSPGDESQTEPFPPFPSTPDCHEDSPASQPGYFHDQPNGMNLLGQDNTADAHRDPSSDLMNGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5F7</accession>
    <name>A0A317X5F7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">S-adenosyl-L-methionine dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_342240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470192.1">
        <property type="nucleotide sequence ID" value="XM_025607045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5F7"/>
    <dbReference type="STRING" id="1450535.A0A317X5F7"/>
    <dbReference type="GeneID" id="37109188"/>
    <dbReference type="OrthoDB" id="10061782at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016584">
        <property type="entry name" value="MeTrfase_VrtF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011491">
        <property type="entry name" value="Mtase_YbcY_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY93431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="25774" checksum="FF7893856F104D99" modified="2018-10-10" version="1">MAKGYEAYSSLLLQAYDILVHWFNDNYVWRCPLPVLNAFFSANVGPRHMDIGAGTGLFPLNHRDKMRQSSQDWPLHLTLVDMNTLCLQKAASRIGCPSKTTCVQADVFEPFAVPVAQSALAAPPKFDSISLMYLLHCLPPPSDHKATVFAHLKDHLTTEGTLFGATVLGTGAHHNLLGRLTIRFYNWKGIFGNKDDSPEVFVKALENEFEEVETHIVGVVLLFRARKPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5V8</accession>
    <name>A0A317X5V8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS alpha-glucoside transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_553835</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY93963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470724.1">
        <property type="nucleotide sequence ID" value="XM_025613679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5V8"/>
    <dbReference type="STRING" id="1450535.A0A317X5V8"/>
    <dbReference type="GeneID" id="37115822"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF71">
        <property type="entry name" value="ALPHA-GLUCOSIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G02650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="431"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="47"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY93963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="523" mass="57271" checksum="469583A72BDA3223" modified="2018-10-10" version="1">MGNISEQTVVLALPAGVGEPESLQFVQDEHALGFWQAMRRHWPAVAWASFMNLATILKGIDGGIVKGLVGLDVFKETYGYNYHGSYILAAQWISAFNYANLLGAIVGALCSGVAYDRFGPRVMIAVCSCLSIGFIFVQFFSHTPAQLFVGELINGCVIAFYPICASAYVGEVTPLALRGFAATMTNLAFSIGSLIASGVLKGTSSMDNTLSYQIPIATQWALPCIMLALIFFCPDPPYWLCRKGRHEAAMASLRRLATPAVDVSRQLAHIQETLHLEASFQDNRPPYLECLRGPNRRRLVICVMAYSMQAFTGNVFFINYAVHFMELAGLDSSHAFSMNIGLTGLGLLGTCLSWLLLPYVGRRSMYLSGCSALAVVLCLIGVLDVVPQTSTTVWGQCGLMLVCTLVYDLSLGPICYVLLAEVSSARLRGLTIALATMSCYVWSVVFAVAIPYAMNEDEGNWRGKLGFLFAGTSALCTGYCFWWLPETRGRTFEELDVLFERGIPSRQFRNCVVELEYFCGISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5W8</accession>
    <name>A0A317X5W8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_458121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470767.1">
        <property type="nucleotide sequence ID" value="XM_025607774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5W8"/>
    <dbReference type="STRING" id="1450535.A0A317X5W8"/>
    <dbReference type="GeneID" id="37109917"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000014">
        <property type="entry name" value="Probable acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000027">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="47"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="164"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="278"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY94006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="441" mass="48411" checksum="EB136F7313396FB3" modified="2018-10-10" version="1">MSRMYRLCRTLRPARGAPLRPLALQTLTRCGFSTSASHSLMELTGFSEEQLTVRDAVSAVCANFPNTYWQDCDQNERDPKEFHAALARDGWLGIALPEELGGAGLGISEATMMMQTITQSGAGMAGAQAIHANVYATQPLARFGTREQLEETIPNIINGTWRTCFGVTEPNTGLETLKLKTLATKIPSRDAYSVSGQKIWITCAQVASKMILLARTTPLEEVTKSTQGLSMFCIDLDRSQPGLEMRKIKKMGGRAVDANEVFFDQYEVPAQTLIGRENDGFRIILHGMNAERCLLAGEALGLGYAALERAAQYAKHRVVFGRPIGQNQGIAHPLADAYMKLEAAKLATYHAARLYDASKQDESIPLHSVGVACNSAKYVAAEAAFTACERAVLSHGGMGYAMEYDVERFLRECLVPRIAPVSREMILNYVSEKVLQLPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X702</accession>
    <name>A0A317X702_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mog1p/PsbP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_508780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471155.1">
        <property type="nucleotide sequence ID" value="XM_025609677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X702"/>
    <dbReference type="STRING" id="1450535.A0A317X702"/>
    <dbReference type="GeneID" id="37111820"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="212" mass="23801" checksum="2EA934AA2825BB45" modified="2018-10-10" version="1">MTTTYTPQPLYGGAIKALIPNNWIDASTLRQIPDHQELYLSPTTLSTLIYEINEYVPTSTSLTTLTNYTHLLPPSQAQSQSHNQEKQRGQESLDRAAVIYHLHDLLDEGDELDMIIPPTRVTVGKGFEEKGKGRRYTGCAVFKSTSKWKETTTKCWFLVVRLEEQETDLVVWGNVPGGELSGEELRMEEEGMGALVGALGRELKVVEWDLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7F1</accession>
    <name>A0A317X7F1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Leucine rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_446026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471230.1">
        <property type="nucleotide sequence ID" value="XM_025607521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7F1"/>
    <dbReference type="GeneID" id="37109664"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59152" checksum="CB8D7465B65089D3" modified="2018-10-10" version="1" fragment="single">PFVEINVNEKELTDKGFDEFIGVLIKCIKFKDDEHPLGRTRVTELHLQGNQLTLESLSQLAEVVALSAGDLRELDLSQNKIQIETAEDIEQWVSFLKAFENCFVLKKLDLGGNPLGRLGLEHFARVYLKSGLDFLEDDADALLGSELADECSPVETVAKSGKENEPKHLKKKSPHKGKGARQSSHTHVDPTGIKKHACTRGLRSIPYLVLSDIGLSSTGALHLMSMLNVQRTREQLLKYLPSGKPKGLPGSEALCKSIIWRPNDTLDAHTQRLLEVSEALRDMKSDSDSEEEDVNDEDDAEKTAQNKLQNDLKGEYSRKSKRVRLQALKEDGVHGSTIWGTALKMMLVSRVILLDGQEHPKEVSEAQDDKGKNERDDEGDNDSEGANEDSSETPTFSHIENRATGPFHPSAQAFNFDFPTLQEAHEPFVSEGAASQDEAKNPPSGEQTPHQSSLALRAARKLPRDLPFDLLRRVIAEAVGADGILDHDQQERIIEYGASWQALANELKFQGAEEHQQIWKLLDTLKCFEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X895</accession>
    <name>A0A317X895_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_531404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471192.1">
        <property type="nucleotide sequence ID" value="XM_025610893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X895"/>
    <dbReference type="STRING" id="1450535.A0A317X895"/>
    <dbReference type="GeneID" id="37113036"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="245" mass="27080" checksum="A2A200CA19A787EF" modified="2018-10-10" version="1">MASNPPGACCAQGFKHEGTPVGEVKKINNIDTYIVYPKDNKTPEKAVLFLSDIFGLFTNAKLVTDEFANNGYLCVLPDLFNGDAIEPAAMESGKFDIGAWFPNHQPTHVDPIVESTIKYIKGDLGVKRIAAVGYCFGAKYVCRFMKDGQIDVGFNAHPSFVTHEELGAIQGPLSIAAAQIDSIFTTQLRHESEETLIKTGQPWQINLYSGVSHGFAIRADLSNPHFKWSKEQAFCQAVAWFRQYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X898</accession>
    <name>A0A317X898_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division control protein 14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_457173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471587.1">
        <property type="nucleotide sequence ID" value="XM_025607734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X898"/>
    <dbReference type="STRING" id="1450535.A0A317X898"/>
    <dbReference type="GeneID" id="37109877"/>
    <dbReference type="OrthoDB" id="5357220at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="297" mass="32878" checksum="7DD18F83B93F7785" modified="2018-10-10" version="1">MEALLAHSFDYLSSYEPSKVRKGLRQVEGLLAQICLSKSKRPASDKRRSLLSFGAPQPPVPKTLSELRDDPAFREFFKLQEGFQWNVAMRLVTCLEHLLGRGSNGTNDLLIVSTLDLIQGVLLLHPPSRTLFAREIYMNLLLDLLDPINCPAIQSATLLTLVTALLDHPANTRTFEELDGLLTVTSLFKQRATSREVKLKLVEFLYFYLMPETPMIPTSAVSAPNTAVLGHQRSPSKLAAAQASRSVNVPGAHGGGKAYRDTRTTDEKQALLGRYLNNVEDLVEDLKETAPFGATVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X8P3</accession>
    <name>A0A317X8P3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_542250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471725.1">
        <property type="nucleotide sequence ID" value="XM_025613083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X8P3"/>
    <dbReference type="STRING" id="1450535.A0A317X8P3"/>
    <dbReference type="GeneID" id="37115226"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016237555" evidence="2">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="269" mass="28878" checksum="B3F75FBCAA6821FA" modified="2018-10-10" version="1">MKLSAVLSTLMVAGLVAAAPPAPRPTGLQIHSHPDSPPNAPAPKPHDDGPHRRDDGPKLPKDDSKPHDSPKPKPKKKDPAPKDLKGPKDPKPHDHGPHKRDGPKPPKDGPKPNDSPKPQPHKDAPAPKDPKPHDNGPHKRDDGPKPPKEGPKPDDSPKPHKQAPAPKDPQGPKDPEPHDNGPHKRDGPKPPKKGPNPGDSPKPKPQPHKDAPAPKDDKPHDNGPHKRDDGPKPPKNGPKPDNSPKPKLQPHQKAPAPKDDKPQDPPRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X977</accession>
    <name>A0A317X977_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_213048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471656.1">
        <property type="nucleotide sequence ID" value="XM_025606169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X977"/>
    <dbReference type="GeneID" id="37108312"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY94895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="161" mass="17615" checksum="874451ECE15A5374" modified="2018-10-10" version="1">MDGVAGTEVTCREAQESQAGRESVETNGGNRETEDRLTMVIENKENPAGSSSSAQSWTTSSLQQCFSLSLPAPVQIMPHWTLLEECREKGFFASSAAMTSPPMDGTAPLFPSLVSVPLHPRSRCFARRFLHVLACPRFVSPWSAPQTLIALNSSVRSLFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9G9</accession>
    <name>A0A317X9G9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Synaptobrevin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_582217</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the USE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471592.1">
        <property type="nucleotide sequence ID" value="XM_025615465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9G9"/>
    <dbReference type="STRING" id="1450535.A0A317X9G9"/>
    <dbReference type="GeneID" id="37117608"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019150">
        <property type="entry name" value="Vesicle_transport_protein_Use1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050">
        <property type="entry name" value="USE1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13050:SF7">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN USE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09753">
        <property type="entry name" value="Use1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="103"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY94831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="37318" checksum="F46273C990EBD794" modified="2018-10-10" version="1">MTLTTYASSPDSPDLAILNLSRLFARLEHNLLSSAADLKPLRRSEYQRMRVGANIEYARTNLQSLEQTVPQIKTTDRRNDLQTDIARKRQILKRLQNVLDELSSEAEARPAHHIDEEDEESSLDSEDLLGTPEEGSTTDEISNEERDDRDNAPEGREPTAATLPPTTTTAETSPPPPEATPAPPPPPSSSSTLRNRSNAPTTTSPTATATGSSLHETPSSPQPSSPSSTARLQATEDTLSSHRAEQEDLTSSLLALASQLKSSSQAFHSSLEAEKSVLSRAVDGLDRTTGSMQAAERRMGMLRRMTEGKGWWGRMMLYAWIFGLWVVAILIVFLGPKLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9Q0</accession>
    <name>A0A317X9Q0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_531188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472025.1">
        <property type="nucleotide sequence ID" value="XM_025610843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9Q0"/>
    <dbReference type="STRING" id="1450535.A0A317X9Q0"/>
    <dbReference type="GeneID" id="37112986"/>
    <dbReference type="OrthoDB" id="329272at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="229" mass="25665" checksum="3FAEFA7EB3815D11" modified="2018-10-10" version="1">MSPPAPTFTTTLIPPPGKSTPLNLPIFPTPTTPTSSGVPLTDALIIRSLVFINEQNCTPEGEIDNDDARSWQWVIYHEPQPSATTPVSPTESKIPVAVIRLVPPPHEPHEALTHPESAGSLPKWDTEHEPYVKLTRVAVLKEWRGYGLGRTLVEEALEWARGHAEEIERAYAEVAGEKEKEWKGLVLVHAQTQVERMYARMGFETDEGLGRWDEEGIEHVGMWRRVQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA06</accession>
    <name>A0A317XA06_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ABC1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_532683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470509.1">
        <property type="nucleotide sequence ID" value="XM_025611171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA06"/>
    <dbReference type="STRING" id="1450535.A0A317XA06"/>
    <dbReference type="GeneID" id="37113314"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="3">
        <location>
            <begin position="214"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY93748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="622" mass="70155" checksum="832C56AE7DDA35AE" modified="2018-10-10" version="1">MRAALRIPLRASNFDPAAVIRSSSKPSLAIPSANAAPTVFLPRRLISSSTASSPALCSQRFTGRLAPSVPRATYATRTSPLFESPKAEQHDRKQSGSGQSRRKVIKYAVIGGTIVVGAVVFSDQVQHLYRAAARTGRVVGTLAVCINDYRVTLKQETSTPEERSDAIRACHKRCAERTLRVLEKNGSIFIKLGQHLSSMGYLLPIEWTTTFIPLQDKCPVSSIESIEKMFVADTGRPIDELFSSFDPEPIGAASLAQVHIGTLKETGQKVAVKVQHPALAEWVPLDLALTRFTFSMLKRFFPEYDLEWLSREMDLSLPQELDFRMEAENATRASEYFKKHSDAPLVIPEVMWSQKRILVMEFISGRRPDDLEFLDSNHIDRDEVSAALAHIFNEMIFGDNAPLHCDPHGGNIAIRLNPNRRRHNFDIVLYDHGLYRDIPQDLRRNYAKLWLAVIESDLPRMREYARKVAGITDEQFPLFASAITGRDYMVLKNKDITSARTSAERDSMSGSLADGLLQQLVELLGQVPRIILLILKTNDLTRSLDENLHTRQGPVRTFLILARYATRTVFEEQIDSVHESGGLLRPRNFWRFLCAWTGYLRVELKLSVYETLLALKSRFGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAY4</accession>
    <name>A0A317XAY4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="4 9">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_282768</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="4 9"/>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471488.1">
        <property type="nucleotide sequence ID" value="XM_025606640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAY4"/>
    <dbReference type="STRING" id="1450535.A0A317XAY4"/>
    <dbReference type="GeneID" id="37108783"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000369">
        <property type="entry name" value="Leucine carboxyl methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 9 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="192"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY94727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="364" mass="40316" checksum="B41046AF4610401A" modified="2018-10-10" version="1">MSASHIPNLNSLRRGGGRGRFRSRGGSQTGDASHGSHGAKDRVVQGTDNDASVSRLSAVSLGYLQDAFAPALTAPGMETRRLPIINRGTYVRTTAIDHLVTRFLNSHPPQTQKQIISLGAGTDTRVFRLLSSSPRSNILYHEIDFPVNTAAKIKFIRAAPLLQRVLGSHDDVVISPANDALHSSSYHLHPLDLRSLSTSPRLPGLDPTLPTLLISECCLIYLTPEEAGSVVRYFTEELLPSTTPVGLIIYEPIRPDDAFGRTMVANLATRGIQLQTLQEFASLEAQRRRLRELGFVRGQAAADVDFLWERWVPETEKERVAGLEMLDEMEEWRLLARHYCVAWGWRDGESGVFEGWRGVEGQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB02</accession>
    <name>A0A317XB02_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mitochondrial outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_285455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471583.1">
        <property type="nucleotide sequence ID" value="XM_025606663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB02"/>
    <dbReference type="STRING" id="1450535.A0A317XB02"/>
    <dbReference type="GeneID" id="37108806"/>
    <dbReference type="OrthoDB" id="198787at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03193">
        <property type="entry name" value="GST_C_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03078">
        <property type="entry name" value="GST_N_Metaxin1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021211">
        <property type="entry name" value="SAM35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF44">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN (SAM35), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13180)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17172">
        <property type="entry name" value="GST_N_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10806">
        <property type="entry name" value="SAM35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="3">
        <location>
            <begin position="80"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="2">
        <location>
            <begin position="227"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="297" mass="33573" checksum="C383F4968932E21E" modified="2018-10-10" version="1">MTPERRDIPGQAPDNASTASRARDFFSVPTPVKRIFDRFPLVTYPSNDLPHSAWSDKRGNRLYVFTDAAGASRGRPSFNPQCLKWQAYLRFVGIDFAVIPSNNHASPSGALPFLIPAHPVSNNTPIPSSKLQKWAIEQVHCEEEQQLDLRFEVYASLLDHRIRNAWLYTLYLDPEEFAAVGKPLYVDPSSTHSAVRTALAVQLQQAAQTEILKTSSYIDVGALEAEASDAFEALSTLLGDNIHFFDRPNPGLFDASVFAYTHLILDEELGWQRNRLGQLLRKHENLVQHRERLLKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB23</accession>
    <name>A0A317XB23_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of phospholipase D SRF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_286254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471613.1">
        <property type="nucleotide sequence ID" value="XM_025606674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB23"/>
    <dbReference type="GeneID" id="37108817"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="42452" checksum="FAA2D655AD9A118B" modified="2018-10-10" version="1">MAQDVRDTRLQPPDAGPLSDEQLSEQPSAPEWMSAQSNYSTGALHSDNDLGHHDAVELSAGNSRSPESTVVGEIENSPAMGRKPRTLPAWIRSVEYTDDDAEAAVTDRLLPMQPGDAVVAQHNHSPYATSRPTLSSGQGEGSDRNIGRERESRWKNFSRDIVYPREQGVEEKIVTPDWLEENVGDYSQPWRGQLSPDEDTEDPLRKRRRREIWIKRFHNTLLKSPMVPLIFRLTVWCFSLTALALGGSIQHLSGKYKHPQGPSALMAIIVDAVALVYLIYITFDEYTSKPLGLRSPSAKARLILLDIFFIVFDSANLSLAFESLSTVRGACTMAEVNQEVAPKNDAICDRQIALACVLLIALIAWLTTFSISVLRLVERVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB29</accession>
    <name>A0A317XB29_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_134120</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472460.1">
        <property type="nucleotide sequence ID" value="XM_025605675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB29"/>
    <dbReference type="STRING" id="1450535.A0A317XB29"/>
    <dbReference type="GeneID" id="37107818"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF2">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="18">
        <location>
            <begin position="33"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="331"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="454"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="331"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="454"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="616"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="764"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY95699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="779" mass="86303" checksum="D8BB37FA000AD697" modified="2018-10-10" version="1">MTADSGLSAAGSSTYASNTLHVGDGTWDSQRDTFLLPNLMGINFDTMRYNGMGNRFKDMPEYHTLIIVHGVIATIVFLFLVPISVLIIRYYSRWNPYWAFKLHVWCQVLTLLLSTVVFVFGWFAVGPKRSLTNPHHGIGLAIYVMVVFQVLWGWLVHKLERNKKRYHVPLKLVIHRWIGRALAILGLVQIPLGLTLYGSPKVLFILYSIAAFALLVAFFVLSYLYDTEGYPMEGGYESRLSYVSGPSAADDHRRSSFGRMATAGAAGAGLASLFRRRSRVKDHDYDESHTSYSDEKHSDEGPRRGGTGNLLLKLGALGGGAWLAKKFFDRRRERDDDTESGRYSRAHTRSDSMTEESLSRLEDERRAEPTQRTPLNRPSSRPPSRPPSRPPSRPPSRPPTRPLSRPQSPGSSYLYDSTYLSERPERKPSHGLRDAVLGAGAFAAFKNFFSRRKSNAEQRRVEEMRRREEEDERLARAESKRRYPGEAYYPRHGRPHSFTATDLSTELTRPPRGPPHGDSIVSAIPAASGAIGGARSDIPPPPGPPVPPTPASEYPGPAPSAHGPTDLASGVAAGAAGAALAESSTRHRRRSSSRHRSSSRHRDPIASPPVSVKVKMHNDGRHVTLRRLTDEEAAASREARRRERRNSRRRAGSASSLSGNEGGSYDRWRRVEELERQQQEQMQREQAAAAAASAAPSSSMPPAAYYAPPPPQNGSHIPMPPPPPPPVPSSHPYGTGSIASPGTFTGTEASGDYASNRRRRRAERARARQDRQQHGVEFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XB64</accession>
    <name>A0A317XB64_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_562641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY94912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471673.1">
        <property type="nucleotide sequence ID" value="XM_025614303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XB64"/>
    <dbReference type="STRING" id="1450535.A0A317XB64"/>
    <dbReference type="GeneID" id="37116446"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000002">
        <property type="entry name" value="2-hydroxyhepta-2,4-diene-1,7-dioate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="82"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY94912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="295" mass="31343" checksum="033D834D1271A62D" modified="2018-10-10" version="1">MSKVASTFSRLVRFIPKSNPSKVLIGEPVDASVDVGLAVYQGKDVAVRPFSGSSVLSPGEKTDATETIERILSPLAQSEVGTIRCIGLNYVSHAAEMKLDIPEVPTLFMKPSSALSGPWPAPTVLPKLTQVDNTGDYESEMVIVIGRDAKDVSEADALDYVLGYTAANDVSSRTYQMNQSQWCFSKGFDTSCPIGPALVSAALVPDASKLHIRGSKNGKVLQDCPLTDLIFSVPKLVSFLSQGTTLPAGTIILTGTPPGVGAAKNPKEFLKHGDEFAVELQPHVGTLITKVENQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBN4</accession>
    <name>A0A317XBN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-methylsalicylate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_600991</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>6-methylsalicylate + H(+) = 3-methylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:23112"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17231"/>
            <dbReference type="ChEBI" id="CHEBI:36658"/>
            <dbReference type="EC" id="4.1.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:23113"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.52" evidence="7"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472747.1">
        <property type="nucleotide sequence ID" value="XM_025616362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBN4"/>
    <dbReference type="STRING" id="1450535.A0A317XBN4"/>
    <dbReference type="GeneID" id="37118505"/>
    <dbReference type="OrthoDB" id="2832284at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047596">
        <property type="term" value="F:6-methylsalicylate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF29">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="9">
        <location>
            <begin position="56"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="319" mass="35271" checksum="601A31AF26D58F7D" modified="2018-10-10" version="1">MPTGWLDVHGHFAVPSTAAEREAAAKELTDDLRFITTADRLKWSVEESLTNTDKMGVTMQMLSNVPSTLDGLRQANDFGASIINNHPNRFGLFAALPTDIPHACLEEIDRTLKYSTPPDGFAVHPCHNKVYLSDRSLDPVWSKLNTLKAVLYIHPDAYVPQFRDRPGSLIEVTFETARTLTDMLYTGWFKRYPDIKVIFSHCAGAFPGLYGRILRLGTESWVSNPENITVEEMETQLGRLFIDTGGTALTGLPAAERMVGVKHCLYGSDCGAPCSTIDTMMRNKQDVVDFERNTGVQVGTIGGNAWELFPGAKKRAESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XC15</accession>
    <name>A0A317XC15_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_455896</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471993.1">
        <property type="nucleotide sequence ID" value="XM_025607679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XC15"/>
    <dbReference type="STRING" id="1450535.A0A317XC15"/>
    <dbReference type="GeneID" id="37109822"/>
    <dbReference type="OrthoDB" id="5022096at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY95232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="396" mass="43556" checksum="318402335C8AF78B" modified="2018-10-10" version="1">MAASSHLGGAGLPDVSQGPQILAATSITTIVALFVVLARVYVRVFVIRNAGLDDYIMVLTMALSLSGWAVVIPEVLYGAGRHTVYVKNTVTIAMHLNFATQAIYMWVIGLVKISIGLFLLRFAPRRSYKIFIWVVMVVMALYTIIFFLTLVFECKDMRSIWDENVKSKCFTTTQLLKLSYTNTGLNILTDLIFAVLPAIMLRHLQVNRRVKASLICILGLGIFACAAAIVKLSVLPNYGRTGDLLWDYSTLTIWVVVESNMGIIAGSLPTLKPLFKQVLGSYGSQTKTRPYTYGSKQYRLHSLSRSHQGQQKSLRNGTLSGLDPGGDREGSRMSPGHLATTKSTTKSPYGDSSNSSEEHILSRQESRGIILTTEVVVSHTSAAAVERNPGRRDDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XD26</accession>
    <name>A0A317XD26_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinesin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_274887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471201.1">
        <property type="nucleotide sequence ID" value="XM_025606584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XD26"/>
    <dbReference type="STRING" id="1450535.A0A317XD26"/>
    <dbReference type="GeneID" id="37108727"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000072">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="2"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="571"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="617"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="495"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="109"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY94440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="748" mass="83740" checksum="C05A4BD6FF25FC39" modified="2018-10-10" version="1">MSVRVVARVRPLLKSERELDVILRTGSSTQAVPGKSDKTSEEKGALAALRDRDTLVRIPNPKNEGEEYSFQFNAVYDAEASQQELFDAEVAPTVKHLFNGFDVTLFAYGVTGTGKTHTMRGGKSLADRGAIPRLLSSIYRRSRKMEKDSGGETSVNVSLSYYEIYNDKVFDLFEPPEKRTLAGLPLRDNGGKTVVVGLTERPCHSLKEFESLYDQANTNRSTSATKLNAHSSRSHAILCVRVAVSTGDKTRISTASAIDLAGSEDNRRTDNDKERMVESASINKSLFVLAQCVEAISKKHSRIPYRESKMTRILSLGQNNGLTVMILNLAPVRSYHLDTISSLNFANRTKKIEVREVENEPMFKGPPRPAPRPSMTTQRQPLRPLTASVNVNLTTVVKDKDTTKTLEKPAKAFHVYSDKSHPRIMAQFKKPDAPKRTSLSSDISRLSSKPTRLTQPAHQPQNHYDDISAAKIEEMVEKKVEEILAVRAVSEQSRQTQVRELNKQVQRRLELLEQRIEGTEDARAEGLSYLLMAKQHQARGEDSFALRMYQLALPYFPNNEKLSKKISTLKERMQGKSREDTDTTGTIAIPGAKRELGSMLSIKKQPAKTNLKRFAEDSDADYEEQQEEALEQFSDEDLEEIAHSRRKKRTRTKTPMDDDADINEQPPSPRTIHLLSIINSRDISQIKLLKGVGVKKAEAIVDCLCEMDQHTACPDDEARVHINSLAELSKLKGVGLKSVQSMRNGVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDA9</accession>
    <name>A0A317XDA9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein artemis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">DNA cross-link repair 1C protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_620001</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472348.1">
        <property type="nucleotide sequence ID" value="XM_025616905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDA9"/>
    <dbReference type="STRING" id="1450535.A0A317XDA9"/>
    <dbReference type="GeneID" id="37119048"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF8">
        <property type="entry name" value="PROTEIN ARTEMIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23023">
        <property type="entry name" value="Anti-Pycsar_Apyc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="14">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="507"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="595"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="626"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="641"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="664"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="718"/>
            <end position="736"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00039759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY95587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="772" mass="86879" checksum="D176ECF91FB0EB05" modified="2018-10-10" version="1">MSTFDGAVREFPSIQIDYFRKNPDRPPPLACFLSHVHSDHLQGLESFRTTFIYCSPATREMLLRIEKYPHRMNFSKGILESRRLHYKHLSKLLRPIPLNTPTELELTPRLSIRVTLFDANHCTGAVMFLVEGNGKAILYTGDIRAEPWWVNSITRHPVLIPYTLGNKRLDNIYIDNTFAHPSHLFHAFPSKAEGLKELLAKVQSYPDNTTFYFRAWTFGYEEVWMALSAALNSKVHVDRYQIDLYRSLASQGVSDAPFLCGYELGNRFVSGCLSEDESSRIHSCEPGVHCRVAASRNTVYIAPIVNRTMDGSEMPEIGAGGGGGDLYQVHELELQDQSALEKLEKLCLERIHDIQALSQTRQALVDAFRSKTNVLSLDTYGMKDAHEMSLESFISILSRGRPDGEDWSGNVNHHTHLQDKQGNPLPRIINFPYSRHSSYDELCDLVSAFKPKDVHPCTVDPMNWDEGVSIQTLFGQLCSGTEFAHDQYMRDMTANDPDLRARKRARYEGSFRTQSSQQTSSGIDSSVPEHPQPTTPEPLSSSSDQIPLPSSLDPINEPTPIPINEPLTIPASTPGAAKARRDEIRRAWHILNNADPPERSLYDLGPLPSSWTTTDEEEISPTPHSLPERPLKIKDKHIPVTPTSPSITNPEPQNTSIDDHPEDPNSSSQPQPNSQLSQSLSLSSSAFKSQECGQNSDHHHYQDSDEEDITAIPSYDGTDDRPRRQRQDTRRSISTQIRRDAYLAARADSFDAWASVSLMSTGNNHTEEEIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDR0</accession>
    <name>A0A317XDR0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell morphogenesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_621131</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471431.1">
        <property type="nucleotide sequence ID" value="XM_025616978.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317XDR0"/>
    <dbReference type="GeneID" id="37119121"/>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="374"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="990"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1473"/>
            <end position="1738"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1771"/>
            <end position="1951"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1989"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2432"/>
            <end position="2472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2528"/>
            <end position="2584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2432"/>
            <end position="2445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2453"/>
            <end position="2472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2537"/>
            <end position="2547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2574"/>
            <end position="2584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY94670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="2584" mass="289172" checksum="301E00161953C702" modified="2018-10-10" version="1">MASHPSIKAGPIQPTPMPLIPDDSSPVSHHSFSTPPDRLVTRSTPSSTVHSRETSTVRGGADPSALAPSSSQPQHNRRGNSHSKSPEPNTGRPGFGYDVGLERRPSNSYGHHRNTSIVHGIQHSRNPSFAASTTSTSPLSPELIASLGRGGATEQESMGSVRMDQHELHSTFQAQGPNGASHSLQGTLSTIEDRDMDDVAEGTPANTAHRRINSNGKPWQERSHSRSHSRHHYGAESKTVGEYALHHLFNSFVGQADNKINQAIMKLGESDAPVEEVCGPGVDSNFDQLISALGHIARQKPKPLIDTIMLWRKAKGDAATVAKQAAGQKSSENGPLIRRNTEPPQIIAESTTQTDSPPSSTTLYSRHDDVILTERRATVSVYLVCRVLIEIFNQSSLASITLDMADRLEDIVFGQLKTVDPEQISASPLRMANWRIYSQVLGIMSENNFTSVSARFLSELEKAQKDETLRGPSKDGDAKAELLILGMRHIRIRTHPDTWPRSCDFMRSLARLFGNAHGQRVKQAYCYIFEKLLLPVAASPNCDLTLPKWKDFLELVQSRLSQMLTKPRHWTVAFPLHVLLLCVSTKENFSSQWLSVIQSLPPRLKDRPTRGPALQAMCRLLWTYFFRYSESPTATLRKVEEVSRIALPAGKRTYLSTDSAVAEPLIQLVRMIGFKHPDVCFRNIIFSLINSDLFLSGKELKIEQMEPEKMVIGIRSFLAIMTDLENCDQLCPPFPTGSIPNPFTDISSSTYLHRPQYLADPRLPNAQRSREDAASPPVNTSRLSDNVKEYYIRFCDILGKITLLCDNTFGGQAALDEKFGGTTPKTPISEAFSFGRRDDHPNALDQRQGFYDLLHVAVQALPRCLSDRIPFNSLINLLCTGTAHVQTNIAFSSAESLKAIARQSHAQQVTIGFARFIFNFDARYSTMSDEGMLGPGHIESTLRLYVELLRIWIEEIKQKTKDAAADSGEKTGSGSRALQLDLSSVLAQVEEVESHGLFFLCSQSRRVRAFAITVLRLITEFDSALGKENTRIIRILEADSQQILDVNDEQLTVAERSRIQKGKRRSAFQNTLIELCSSEVSYDSTLWSKVFPNIIRISFETCPFAVTLGREIVCARLVLMHKTITSLAESPQHPQYGPIDAIQARSYGRSNTTAEILVEQWKLYLVMACTTLNSVGAQSQSQLANAQHARKGSKGSQQTQDKISSARSLFAFVIPLLSAERASIRNAIVVALGSINKNLYRTLLESLQYAVTTCNEEAKIRIGTHYRTPSSPRRNRRTDRLRTEVTHVYKLTSHFLKEPEVYNDDWIVNNLVTYAKDLRIFLSDAEVQNDWEFQRLRFHYCGLMEELFEGINRTKDPSRWIPFESRKSAFSLMEDWCGYSPNQSQISQREETMRRNAISQNHESGELRNTAAAMEIEKKNLRAAALSAMASLCAGPISITTESGSVLQFDVGRMLSWVDIIFNTISDKWHAIGRRALKNLIIHNKEHSYLLERSIEMCYVTERPKALESYFEVVTEVLIEHTDYPLGFWRILGAVLVTLGSPKREIRMKSAKLLRILEERQQKSSRLQDFDISISDKTTAVYKLAQFETSKRLAKQHSDLAFTLFSEFSLHFRNLRPDSQRNMVAAILPWVQTMELQVDPNGGPTAKSYMLLANLFEITIRCSTILPNEVQALWQALATGPHGGNVQLVLDFIISLCLERKEQNFVDYAKQVVVFLAGTPAGSKVIEFFLLQVVPKHMVQERKEITPAPPDTRGLPYVADLGTVLPVGNKQAGLSLGQVALIFLVDLMVAPVTLTMEDLVKLLHVVLILWDHYTLTVQEQAREMLVHLIHELIAAKIEDDAPIETRQSIEDFVESIRRSDPKVVWEYEDTTDKEDEEDGSRVPSSMASVTRKVVDFFSLGYEGLNDLWAKEALNWATSCPVRHLACRSFQVFRCISMSLDSRMLADMLARLSNTIADEESDYRTFSMEILTTLKIIISSLAPTDLLRYPQLFWTTCACLNTIHETEFIESIGMLEKFLDRIDMSDPMVVTELIKGQPPKWEGGFDGLQDLIYKGLKSSESLNQTLDILHRLSGLPNNELIGDGNRLLFTILANVPHFLHHFDSEVDDPKTLARATLLARVAESERCPRLAASLLGFANGQYKAENDFLSHIITEVRSYYFPRHDVQSLIFLMGLLTNTTNWFRVKVMKILCVLLPDMDMRRGEVTCHGPDLISPLLRLLQTDLCPQALQVMDHIMTVSANPMERHHIRMSMASASSSRAIRKEYERVQSLYGIPEPTGWSIPMPATQSSITRHNVHAVFYTCAEVDSMEAQETAPTDVEFHADEYNDTFFPMRADTMKSIDTQTDGNMGDIVQKLDSLDDFFEETDPVHPTLDPDATLRGFTGTYADTNASLYDQQTAPILRKSLARTASTSSFHNGLAESRPSNLRLDSMGTPSPGTFTPQAPSKNVRPVSHTRSVTSPVNHLFSTPGSTVQHTTPLIGFESAFLSDDDVEDGLADHKLTIPHPIMQTRSATDGSSSLESMIRSGMRRLTGGAATNREKERQRDLVRAQQRALAQTASSPRVPKVPAEYLTGPVSNPSSPAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDX0</accession>
    <name>A0A317XDX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zincin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_505558</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473132.1">
        <property type="nucleotide sequence ID" value="XM_025609548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDX0"/>
    <dbReference type="GeneID" id="37111691"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="215"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY96371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="630" mass="73117" checksum="89C57B4937A39FFC" modified="2018-10-10" version="1">MATVQPLLLVPIAEEIVPTMQRIVSRYNAVRNEILRTVTPETATYDSVVRPCAELDNVISADVHMLYMLQYGAPDRATQDAFVQARRILVDAETGWTARADFFVLLEAVKEKSELVDSESRLWLEREFQDYRLAGHGSLTTPAQREEYRTEKAAISDLERLCHRNLAHEKGGVWFTVDELDGLSDKELAKWVEGTEPANRGKRLVTFANGGYTAVMTYADSAETRERMYRAYNMRVLENGRLLEEIVRRRDAQARRLGYPDHVAVQMERRMIKQIKWVDEFLAQLQEKLVPRGREELEGLKRIRERYLLKQGRSTDDVDDGFPPWDQSYYQRLIEQDFDIDQGKIAEYFPLDRTAAGMLETFASMLDLRFDPIEGLAFPFVWHESVRVFSAWDGRDANAPFLGYLYFDLQWRENKYRGNQCVILQCGSSKPDGSRQHPSVVLMCAFSTNSGTHLLRHREMISLFHEMGHAIHNLLSQTQYARFHGPQGLRDFGEIPSMMLENWCWRKDVLKQLSCHYTQLNEEELLQWRTQHPGEADPPAQIPDQLVGDLIRGQYVGKGLWYCRLLVISLYDLKIHRRGPNQELDLQKLWYDELEKVMGMDYATCRDGYEFATIGHLTAGYDAGYYSYLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XEH7</accession>
    <name>A0A317XEH7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_529584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472953.1">
        <property type="nucleotide sequence ID" value="XM_025610475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XEH7"/>
    <dbReference type="STRING" id="1450535.A0A317XEH7"/>
    <dbReference type="GeneID" id="37112618"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="113" mass="13132" checksum="E06B576360DC7A9B" modified="2018-10-10" version="1">MFILDDAVLRIRQWLRKCMEEHQECSMNLKTPLPRRVVDIGLSDADKVLLYEPGQSDAWSPYVAVSYCWGTQGNLMTTKENISIHKRQIEWKLIPSTLQETISLTRKLGIRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XES7</accession>
    <name>A0A317XES7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_18192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473482.1">
        <property type="nucleotide sequence ID" value="XM_025605977.1"/>
    </dbReference>
    <dbReference type="GeneID" id="37108120"/>
    <dbReference type="OrthoDB" id="2913095at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="2">
        <location>
            <begin position="58"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="262"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY96721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1414" mass="160294" checksum="7B10928EB78F5F21" modified="2018-10-10" version="1">MEAETAIKSLRAFLGNTDMNPEAEEELANLWTDIDCQISKLSSHLSDIEGNRGATLGRLKTHCEEQTKNHPRSQKVVMRFVKVLETLNSIAGDSASGAFPGASACFKGLAILVAGIQNYANLPEELGKLADACMRGLENIQGMYVNAGLAIKIHRRFALIVQICCECANATQSRKYRLKRAVEKTFGDDKIKALMDELSELREDQVESVVNDLHRVTFSTDAERKWRRSLVKALDFHPGELGPNEEPMKSSLGMLYRPPFENTGKWIDSNESFQAWLDGSQTTICLLVAPAGYGKSYLMANLTNRLPPSKARGLVAFYFHEKMDLTPSMVDSAGLVRQAVRSIIWQCAVDYSPLLKSMAPLIQEYGSPEQRDPIELWTRLLVDNDERKRMDHVIFVLIDCSSIGIAAFLPLIRTLNRSRDHKIRLMLTASPDDLLTLSQGDNPSVAKVDLGHHSKPDIAVYATSRMNQMASLGRETNPTVQLYRKKILKELQEKSGGDWLKVTTTLDYIARMETNPGKIDEILNGLTNSRETTTVNLIAELNRQLDSDQIRELNAAIVCITHGFRLWTPEEMDEILRLGYQKDWFCSFRERMRWYPLLDLNPAGYVTWQSPDIPEGIPKRSELELERDVRSAEIDIVHHFLRQVCPEALFRKLEFDTFLEGKRIGTMNPDHLMICKDESNAHIRMALICLQILTTQQAADSLIQYAGKNLLRHLKCTGLSQVAPDLKRQAGRLLAELFTSSKGIKTMFWINPEEKMVGLLGWIMGEGRGQQQWLRAICDDWLNSDRGGNLLASWFKDPVVTADIVEQKQMNLVSAFCNSSDTRYELLFKAISENIMLELCIAQSHEAILTGMEYLTAFIRRISKPQLPLNTKPSNQESEARLPTLTEWLMVDEYYQPYIRTIDSTNPPSVELMNFKAVYHARIAASIDLLIEFKNIGEMEMTEAIRIRDERLSEALNIMPECILALRIQFRHERNSTKALELIDRLISSVKKEVDGGLEAGNAIIASLVLEKGNRYWELGPEYHNRAIAAYNDMWKYGFPLEPDPETMMNNIYKLNEPSGVFWDLIRQMNSSFEKWKRHVAQAWLGIFGTEAFKNLARKAVLQKGSLGLLVDLLRQAWESAAAQGDVLIRCEFTLCCASIYLTALRRFPSDAEATANIIDNLERSLQLNAAQPQYTLKPREANEADDILAELYLRQAIANNSNQDWGQRFEQFMQRSNHTKSRVVSCCFARYVYMTRGVPQAKAAVQELLKMALEMLSDKDPCNDGLAFSFLSRIMVTFGDLENTKVIGRIFHLIRLSWWTASEKEAADMKVDASAVIAPYTCTWCGEDANNTSVLDLRSCYLCVDCAGTVSLHGKCYEEWRKLGPHAQPCHGHQFLFIPEMYVTPLVNTLVPTEPTVISLSEWKDGLRKKYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XET9</accession>
    <name>A0A317XET9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zn(II)2Cys6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_530211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472249.1">
        <property type="nucleotide sequence ID" value="XM_025610635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XET9"/>
    <dbReference type="STRING" id="1450535.A0A317XET9"/>
    <dbReference type="GeneID" id="37112778"/>
    <dbReference type="OrthoDB" id="5425448at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="461"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="108"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY95488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="814" mass="90544" checksum="F1002354F3839C44" modified="2018-10-10" version="1">MDCGSTGTAAGIDPKILDNWQSDPFSISSWEHHTDYDQSLEWDASPDSSQGDADIVDLNSLNGPLSRDPSAVPVVGQPGDYRGSESSKHAATSPGKFSINDGPIEGTVSGTISPRTLPSSADDNFHLDESWPPFQLFNAMTAGLPMEAPLLYPYAKEPTSTNTVIVEDAGDLSQGQGLSDVPSDQFLSFQNLPQAFPFSPAEPWTAPAASATAEHMSNSTPVSLSMGPQSTGKRISHIRDYQGSIRSLDSRWLDGLESQLPSNMTSPGSLSLPPDAAFFKEERHNQEGSQYKSESSSVSGDFPSVYDPYSTTNDEIPAFAERQLEDDGLWKSAQKDSSPPETSQPLQNATAFMVSEDPSESYFVPVSSRPRASSSAQRAPARPQALALQSVATVRKRKQRNSSVHLDQNLPKPLQIVQEDGQGGSIASADFISPPRGARRKGPLSMVGRANAGLRRKNKDTCVQCRLNKRKCDGNAPCDACRPTLHEQPCARACFANIVEYGTCNYVSQRAINHPTVDGTRRVRMDIPFEFDLNDLISFLGERQGRFNIRAKQSWGSLYVLDLGETYKFLRGLSEYNGNSKSNFLEFIDRRIVESKDKSKNWLTCVKDCDPMNNAYSLLSRWNNMPSRASYSFVPLQSGGQEKPMDINNPEDRREILLAAQLSRIICRMLEVEGFRKLERDFYNIKWKQISQDTHMRFLSELGHILLTLRWRVSWWRRLGDGGREPDPSKQHYVDRVDLLCRILYVYYTCVLAKLPSWCAADVPKGIWSTYADAENPVWDDFPVDPTDDGFRQWIDRGQELVEQSGAPTCVAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XF61</accession>
    <name>A0A317XF61_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_541212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473148.1">
        <property type="nucleotide sequence ID" value="XM_025613037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XF61"/>
    <dbReference type="GeneID" id="37115180"/>
    <dbReference type="OrthoDB" id="4504150at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="128" mass="14768" checksum="D0FC574ADBF07D2B" modified="2018-10-10" version="1">MIMLPLIPIISLLISLLFLLIRHRKSILSVLFSRPKPAAAAENYTRLPSNEPEYSNTHRESNIPETPLTKYFDPDTSIIYKGILEPPSPVVSPVIRDSLEEENKGWMDRIVVSLVDWMVEYVRDERSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFB3</accession>
    <name>A0A317XFB3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_619586</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473218.1">
        <property type="nucleotide sequence ID" value="XM_025616871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFB3"/>
    <dbReference type="STRING" id="1450535.A0A317XFB3"/>
    <dbReference type="GeneID" id="37119014"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="14"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY96457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="369" mass="40851" checksum="F6A635E6621BC278" modified="2018-10-10" version="1">MYVCTLDSTSPRKPLILLLHGFPELAFSWRKVLPALASAGYHVVAPDARGFGRTTGWDTRPFDTVDLTTFTGTSLVRDVVLLVHALGYTSVECVVGHDAGAVTAALCAVTRPDLFKSVVLLSHPFNGTPVVPLNTAPFPASSPAAENEDGGSGPSVHDDLLALGRKHYKWYYSTEHASREMENPAGGMHAFLRGYFHVKSGAWEGNRPEMLSGWTAGELARMPYYYVMPAEASMPEAVEVLMREAKEEGVKRCREWLSEEELGVYVREYERTGFQGSLNWYRVRTAQGGKYIWDWEVYAGRKIDIPCSFVSGKQDWGIYQEPGALEKMRDGTVCSDFRELKLVDGVGHWAPQESPEVVVEVVLGLVKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XFE2</accession>
    <name>A0A317XFE2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_592404</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473303.1">
        <property type="nucleotide sequence ID" value="XM_025616143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XFE2"/>
    <dbReference type="STRING" id="1450535.A0A317XFE2"/>
    <dbReference type="GeneID" id="37118286"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="28"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY96542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="525" mass="57586" checksum="C7192CE11BED000E" modified="2018-10-10" version="1">MEASLGLDEDNGEFEEVKAVRQGLHQRHIQMIALAGTIGTGLFLSSGQAIARSGPLGAFLGYLIMGCVAGFVTLVVGEMGVLIPLNGGIVRYAEFFVDPALAFANGYNLVYSYLVSIPAELVAAAVLVQFWSDLNSAIWITIFGLVMFCTALVFVRVYGELEFFFSTLKILLVIGVNIMVLVITCGGGPTHESIGFQYWRNPGPFVQYLDIGGSLGRFLGVWTALNNALYSYSGIETITVAAGETRSPRQAIPQATKRIFIRILLFYVISIFMIGLVVPSNDPDLDKSGGTASASPFVIAATRAGIKVVPSIINAVVITSAWSSGNSNMLGGSRILVGLAKNGRAAKFFTRLNRFSVPWVAISLYGLFMAMGYMSLSSSANTVFNWLQDLVSITTLTNWLTILVTYLRFYYGCKKQGISRKTLPWVAPLQPYISWVSLFLLSLLLITGGYSTFIRGYWDNETFVSSYINIPLFLILYFGYKVVYKTSIVPLEDIPIQPFIDIANRNPEPLPKPKKGLRKLNILWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UW83</accession>
    <name>A0A317UW83_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_338246</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000056">
        <property type="protein sequence ID" value="PWY65679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461506.1">
        <property type="nucleotide sequence ID" value="XM_025607016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UW83"/>
    <dbReference type="STRING" id="1450535.A0A317UW83"/>
    <dbReference type="GeneID" id="37109159"/>
    <dbReference type="OrthoDB" id="4116913at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF37">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY65679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="613" mass="68759" checksum="19FF823E8EE3D0A7" modified="2018-10-10" version="1">MPKAPRRVVGNPVDSRFGRPRKSCDTCYSRKIKCIEITGSDQCEWCMDQELPCTVPPKGSRRRKSKTKAGSSTTPESVDTNPARASEDIQEEKSATVTVQEERRLPLSQLLNPPEPTSPDESPRQERLKNLFRYYGIPLFSTTAQDWIRSHCQPSNTLSNLSSLSLPWINRQDRPAFASQKSIPSDIEATTVYLPDRFITEACVALYKCGRTGLFYPLVDADASTNIIKTAYSSADKQQPDVITARAFVFSFVAFCSSAGHSEEMTYPVDGGTCALAARRLLHAVDNEPPSLEALQTTVFLVLYHCFEGCLWAVRGVLRIASHLVKDLAPGMGFFQPPSSDRSTIFRNLFWICFLIDKELFLRLGETPLLPAESCVPSDHGESPFRHLSRLLPCVPGVYTSTFHLSILMSKIYSELYAPEAVGKSDIAILRTIRALDDELEEWRLNIPKDIRPTIHASNQPANLQSDVDVLIMHLKFHNCLGCIHQAVSRCQSWSGEAGPVKEALRSSLNVSTQASAASLELMRANPLTLNRECFWLLCFYPLSALLNLFCKIVADTFDCESRLYLSIIKRIPEYFREVDTRHVTAIEKEHLHLMILFSTELLALAEQQVSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYN4</accession>
    <name>A0A317UYN4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_479466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461667.1">
        <property type="nucleotide sequence ID" value="XM_025608745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYN4"/>
    <dbReference type="STRING" id="1450535.A0A317UYN4"/>
    <dbReference type="GeneID" id="37110888"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="5">
        <location>
            <begin position="70"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="187"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY66469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="417" mass="46492" checksum="FFF5A4F9B547C29B" modified="2018-10-10" version="1">MSAIPSHFYRIHPIGNYTSSTKIMDIDIVISEINGFANNLKSGGQMPPRQQERLLEACDRLSMQLKNPEQGFTATAAVKIAIDMGIFDLTINRDPEEITAEEIANSTGADQVLVVERIMRSQVINGLLNTTPQNKYAANEATKALSSQGSMQHMVSFIHNVTACVSQKLPEFLAKTGYRNPNSSTDGPFQYTFNTSNRFYTWLQKHPELHVSFNGMMKATERQDVRWSDIFPAEDRFAVFRGPQSQVLHLVDVAGGTGYNIQHLVEKIPDLHARFTLQDLPEVIAAGCVPVAAQVEVMPHDIFQTQPVTGAHVYILKRILHNWPDQECRQILGHLRDAMGPDSVVLIHDRVFPDEVAGMSKADVSIDLAMMMLCGSMERTEAQFRTLFASVGLRMVRVWRGPAQSQDAVVEAVLAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYS6</accession>
    <name>A0A317UYS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Radical SAM enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_338205</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000056">
        <property type="protein sequence ID" value="PWY65677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461504.1">
        <property type="nucleotide sequence ID" value="XM_025607015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYS6"/>
    <dbReference type="STRING" id="1450535.A0A317UYS6"/>
    <dbReference type="GeneID" id="37109158"/>
    <dbReference type="OrthoDB" id="549750at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051196">
        <property type="entry name" value="RSAD2/Viperin_antiviral"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038283">
        <property type="entry name" value="viperin_w_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339">
        <property type="entry name" value="RADICAL S-ADENOSYL METHIONINE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21339:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT NUCLEOTIDE DEHYDRATASE RSAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01088">
        <property type="entry name" value="antiviral_proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00318">
        <property type="entry name" value="Viperin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="39"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY65677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="332" mass="37959" checksum="37E22A3D99BED28C" modified="2018-10-10" version="1">MKVNDKVLLILSLFVILGLAVFVLFLSWFTKASKLFNPPKCPVSVNYHFTRQCNKSCGFCFHTASTSHVESIENAKRGLALLQAAGMKKINFAGGEPFLDKQRLGKMIDYCKEDLHLESVSIVTNGSLVTRNFLARHGHNIDILAVSCDSFNEHTNTKIGRGSGDQVSKLYKIRDLCREYGIKFKINTVVCRLNFQENMNSFIEDLQPFRWKCFQVLLVDGENESDKRLRDARKFLITDEEFESFCNTHSHQKAFVPESNALMAKSYLILDEYMRFLDRDGRDPSPSILEVGVDEALECVYWDEDSFKARGGEYDWSTHRGICSDAKKGLEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZ03</accession>
    <name>A0A317UZ03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Carboxypeptidase</fullName>
            <ecNumber evidence="15">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_333019</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="15"/>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461583.1">
        <property type="nucleotide sequence ID" value="XM_025606996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZ03"/>
    <dbReference type="STRING" id="1450535.A0A317UZ03"/>
    <dbReference type="GeneID" id="37109139"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4 15 18" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016193633" description="Carboxypeptidase" evidence="15">
        <location>
            <begin position="35"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="475"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="590"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="487"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY66128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="627" mass="70322" checksum="47A8A29AE1B0B3ED" modified="2018-10-10" version="1">MVSLSFRGETTPIPSMASWLISALFLLSPSLVSARSAADYYVHSLPGAPEGPLLKMHAGHIEVDQQNNGNLFFWHYQNRHIANRQRTVIWLNGGPGCSSMDGALMEVGPYRLKDNETLVYNEGSWDEFANLLFVDQPVGTGFSYVNTDSYLHELNEMSAQFVVFLEEWFRLFPEYERDDIYIAGESYAGQHIPYIAKAIQERNKNVQGETIARWNLQGLLIGNGWISPTEQYLSYLPYAYEEGIIKEGSRTAKELEVLQSVCQSRLETGKNKVHLNDCEDVMKGLLDSTISNNQCYNMYDIRLRDSTDACGMNWPVDLEDVKPYLQRQDVVQALNINPEKKSGWVECSGAVSSAFNPQKSVPSVQLLPGLLESGIQILLFSGDKDLICNHVGTEQLINNMKWNGGTGFETSPGVWAPRHDWSFEGEPAGIYQYARNLTYVLIYNASHMVPYDLPRQSRDMLDRFMNVDIASIGGSPTDSRIDGEKLPQTSVGGHPNSTAAEEQAKEKIKETEWKAYAKSGEAVLVVVIIGVSVWGFFIWRSHRRHQGYRGVWHKDMSGSSVLERFHSKRTGGADVEAGDFDEAELDDLHSPGLEREHYAVGDDSDEDDISRQHSRQASRPGGNPNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZ34</accession>
    <name>A0A317UZ34_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_334645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461613.1">
        <property type="nucleotide sequence ID" value="XM_025607003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZ34"/>
    <dbReference type="STRING" id="1450535.A0A317UZ34"/>
    <dbReference type="GeneID" id="37109146"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF76">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16628">
        <property type="entry name" value="Mac_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="269"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY66158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="694" mass="76179" checksum="F449CB2DD7AA7C3B" modified="2018-10-10" version="1">MATVASTSVMNDHDPEKEPRSDHSPSRFTAVNGKETLISAGSAPTPAANGSSGNEEHLESSDTLIRNGFDTHSRLDEQIQGNRISGSSKTSNEQDNRHSQRSSGSESPVLTSKRKRSESREQEETHNAPRKAPKSPAIRLDDSIDSLPQAATSSDASMSHVESDVNKSSENGGGTSSTPWHEYDSHLVHQAQRAQQFDASDAQLAEALQREANDNDPTQKDWDSNCPAEGPAQSEQPSSLTAIPQERPQAAVQVAPKRKRVFSNRTKTGCMTCRRRKKKCDEQHPACNNCIRGGFLCEGYSSRSTWQKPSNSKTPVPLQSKDGYLDVNTPPYVHDISQQHDRQQTSSEQLDPGKIRPIVVNESDRTTTQFNTSPTGTGSGRGPWTKRTWGSTSHPAYMSDHVAKSDYREVPPIHELSRETHQKSDFPIVPSIRELPHGSHSKSGGVPLFQGGLDQRSAHSGNMDTNSPRAQARMALNIEHQLSTRTVSAEDTEKDKMIRGDLYRPYDVHLVEERDRCKTALWRFNNACNPISGLSTKEQSRLLKEVLVPPGSVTSPPPSVASSRSTGSLGQGAIVEAPFYCHYGYNVHIGEDVMISENCLFVDDSPITIGAHTWIGPRVTILTSMAHANMQERKGSQSRYQGRPVTIEEDCYVGAGCTIYPGVRLRRGAYVAPGEVVKSDIVAYGFQGLKPSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZZ7</accession>
    <name>A0A317UZZ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Negative regulator of differentiation 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_478990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461920.1">
        <property type="nucleotide sequence ID" value="XM_025608724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZZ7"/>
    <dbReference type="STRING" id="1450535.A0A317UZZ7"/>
    <dbReference type="GeneID" id="37110867"/>
    <dbReference type="OrthoDB" id="6407164at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12520">
        <property type="entry name" value="RRM1_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12521">
        <property type="entry name" value="RRM3_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12522">
        <property type="entry name" value="RRM4_MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000047">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000064">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000130">
        <property type="entry name" value="Differentiation 1 negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000120">
        <property type="entry name" value="Negative regulator of differentiation 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034195">
        <property type="entry name" value="Mrn1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018835">
        <property type="entry name" value="RNA-binding_domain_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF8">
        <property type="entry name" value="RNA-BINDING PROTEIN MRN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10378">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="190"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="281"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="415"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="506"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="574"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="724"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="587"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="611"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="730"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="770"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY67276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="833" mass="88286" checksum="DE67915C89BADD6E" modified="2018-10-10" version="1">MQTSDASIPSRLIPSKYSHLNADSTGFSHGAYASNNIPLQGLTDRNARRANIPAINTSAPVSDTMAASGTAFDMNFTPLLPSQLLLGSPFQPGTPSAFASPQFANFGGFSQTNASTHAQNHQSHHQLGSPTQPSQNAGLYSGMMSTDGMGNSQMLGAPQSPVGGLGGLGNAAFGSPAASVTPGLLSGTSRTVYLGNIPAETSAEEILNHVRSGQIESVRLLPDKNCAFISFLDSNSATHFHSDAILKKLAIKGNDIKVGWGKPSQVPTSVALAVQQSGASRNVYLGNLPEEMTEEELREELGKFGPIDTVKIVKEKAIGFVHFLSISNAMKAVSQLPQETKWQAPRRVFYGKDRCAYVSKTQQQNAAQFLGIAPGYAHILNSADRDLITNALAQQSVAAAAVATTAGGVNNLGNRTIYLGNIHPETTIEEICNVVRGGLLHHIRYIPDKHICFVTFIDPTSAASFYALSNLQGLMIHNRRLKIGWGKHSGPLPPAIALAVSGGASRNVYVGNLDETWSEERLRQDFSEYGEIELVNTLREKSCAFVNFTNIANAIKAIEGMRNRDEYKRFKINFGKDRCGNPPRQAGNGGPQGRNGPGFEGPQSPSPALNGFQQNLSQSGSGSSPTHPALSPAPGSTGSQNGQHHRHPLQTVSSPSGILNVGANNPLTMYLNQMSAQQAQEQENRLNDPMTLAALHSQPQPPHQQSLYNGSSTAELTNGSIEAPLHQHKPSTNGFLNVTNGSTGPGHHATASTSSLSVPRAQHSRAVSLPSFSQEPFGSVSSQPTRSGVAHQPQSSFSSFTSALGGLSHAGFGLAIQNESSLPGWAEEEIGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V026</accession>
    <name>A0A317V026_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 11">D-xylulose reductase</fullName>
            <ecNumber evidence="9 11">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Xylitol dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_579677</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 11">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>xylitol + NAD(+) = D-xylulose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:17151"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 or 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8 11">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9 11"/>
    <dbReference type="EMBL" id="MSFK01000051">
        <property type="protein sequence ID" value="PWY66498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461696.1">
        <property type="nucleotide sequence ID" value="XM_025615284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V026"/>
    <dbReference type="STRING" id="1450535.A0A317V026"/>
    <dbReference type="GeneID" id="37117427"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="UniPathway" id="UPA00146">
        <property type="reaction ID" value="UER00577"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019569">
        <property type="term" value="P:L-arabinose catabolic process to D-xylulose 5-phosphate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0859">Xylose metabolism</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="9"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY66498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="360" mass="38872" checksum="637CDEF1E0978A7E" modified="2018-10-10" version="1">MENPSFVLRDIKDVVIEDRPKPVLTDPHDVIVHVAQTGICGSDVHYWQRGRIGDYILTRPMVLGHESSGVVVSVGDKVQHLKPGDRVAMEPGVPCRRCDYCRSGNYHLCGEMIFAATPPWDGTLAKYYVNAADFCYKVPDHMSLEEAAMVEPVSVAVAIAKTANLQAHQTVLVLGCGPIGVLCQAVAKAAGAKTVIGVDVVQSRLDVAKSYGTDYTYMPVRAEQGVDPMVHAEKVATQMKEELGLGEGADVVLECSGAEACVQMGIYAAQRGATFVQAGMGKENILFPITAVCTRGLVIKGSIRYLTGCYPAAIDLIAKGKIDVKRLVTNRFPFEKAEEAFELVKAGRQDVFKVMIAGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V0V5</accession>
    <name>A0A317V0V5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylalanine ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_528078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAL/histidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461945.1">
        <property type="nucleotide sequence ID" value="XM_025610409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V0V5"/>
    <dbReference type="STRING" id="1450535.A0A317V0V5"/>
    <dbReference type="GeneID" id="37112552"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016841">
        <property type="term" value="F:ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY67596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="696" mass="74228" checksum="11EA982C5596C2BC" modified="2018-10-10" version="1">MPHLPSSTSHLAATYRTWAQLQDFKANPSLALDGNSLDIAAVVAVAFHGCVPHLSSDPEVIDNINASVRVLMEHLDQGYSIYGVNTGFGGSADSRTHQTTSLQAALLQHTQAGILIASDKDPDHTPGIPGSHSMPSAWVRAAIAVRANTNARGHSAVTIPVLDGLLRLLAHRITPIVPLRGSVSASGDLMPLSYIAGAIEGSPDIYVRVGDGPSARIMTARDALLAANLPRCTMGPKEGLGLLNGTAVSTAVASLALHEAHLLAVTSQALTAMGVEALTGTVESFHPFIHAARPHPGQIESAANILSLLQGSYLAAGTHPTDPKPRTRAGLIQDRYAWRSAPQWLGPQLEDLTLADKQLQTELNSSSDNPLICTASAQIYTGANFQAASVTSGMEKTRLALQMIGRLIFAQATELIDPSYNNGLPTNLVFDDVSLSFTMKGVDTSLAAYMAELAWTAHPISAHVQAAEMHNQAVNSLALISARCTMQAIELVSLMSAAYLYVACQAVDLRALHMAVLKGITTRVAKVTREVFESSLNDHLVDRVVDAVTTAWPTTTRLPIAERCRQAVQAAVPMFVDATTTTTTPTAELRLVDVSGWQQRAISAVIDVYHTTAARFVEHPHTADLLGAGAKVLYTTVRQDLKVPFHRGFVEHPTAQCGELDGRPKKTIGSWISVIYEALRRGDVQGPVLATLRELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2F6</accession>
    <name>A0A317V2F6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UV-endonuclease UvdE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_540667</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000052">
        <property type="protein sequence ID" value="PWY66390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461654.1">
        <property type="nucleotide sequence ID" value="XM_025612964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2F6"/>
    <dbReference type="STRING" id="1450535.A0A317V2F6"/>
    <dbReference type="GeneID" id="37115107"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000012">
        <property type="entry name" value="Related to UV-endonuclease UVE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="460"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="522"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY66390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="695" mass="77689" checksum="882AD73F95817971" modified="2018-10-10" version="1">MSLWISPRQRFHRALLPVQHVAHYHVPQNSGSQFCQVRHLSSVRIIQVANPSPIHTRCGSLPLHASSVTTHPCRSSRPVTASVAFTPSRIPAGSRAVSNVTQAAMAIDEILQDGVDGNVLHEVQDVDVKEEPKIGAAMDPESDEDVPVAAEELQDALSRPPPVHSSYLPLPWKGRLGYACLNTYLRYSNPPVFCSRTCRIASILENRHPLLDPSQPPHPTKNRPDRNQPPDVARGQSYVEALGLTNARDLVKMLRWNDRYGIKFMRLSSEMFPFASHKEYGYKLAPFASEVLAEAGRVIAELGHRVSVHPGQFTQLGSPKDEVVESSIRDLEYHSEMLQLLQLPPQQDRDAVMILHMGGVFGDKEATLDRFRENYRGLSQDVKNRLVLENDDVSWSVHDLLPICEELSIPLVLDFHHHNIIFDSSQVREGTQDIMPLFDRIKATWTRKSITQKMHYSEPTPSAITNRQRRKHSPRVSTLPPCDPTMDLMIEAKDKEQAVFELMRTFKLPGHDLFNDIIPHVRNDENKPFKPPRKSKKNGGFVDLEGQIPPAQTVSEEDAGMGGPDGRVYWPPGMEEWLRPKKIVRTPAARSPRRTPAKKATSENGDTVKQDGEPDGDVLATPVSKTTRGVKRASSVKKPASRKRKASPAISTPSASETEEPEIPEMPALKPSQSNGVRRSRRAKKVDYAEDADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2K8</accession>
    <name>A0A317V2K8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavin-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_478811</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461950.1">
        <property type="nucleotide sequence ID" value="XM_025608712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2K8"/>
    <dbReference type="STRING" id="1450535.A0A317V2K8"/>
    <dbReference type="GeneID" id="37110855"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF4">
        <property type="entry name" value="FAD_NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY67601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="563" mass="63762" checksum="A6556D8723547F42" modified="2018-10-10" version="1">MSSKASQHVGNNRFTRSTVVIVGAGISGICMAIDLLRRTPTRNIIILEKGSRVGGTWADNRYPGAACDVRSSLYSFSFEQCPTWTEEFPRQKELLEYLTDIAQKYGLYRYIRFNSMVQEARWDDSQLQWKVQVALTGAKDSQFQEAYEITTDFLISAVGQLNIPSYPRIPGLDDFTGKMMHSARWDWGYDFADKRVAVIGSGATAAQIVPEMAKTVSHLTVYQRTPNWIFLRGNKPVSAMERFLLTYVPLVRWCKRAMIMRIREWSYSPVTNPESGTAHQVKEWALARMRSNLPDKPDLWEALTPKYSFGCKRVLFCDDYYPTLNSSHVDLETRSIQRITATGIQTEGDGNQDYDLIVLASGFRASEFLQPIKIYGSHGRPLEDIWKGGATAYRGVVAEDLPNFGMLYGPNTNLGHNSIILMIEAQSKYLSTLVGAVVESKEKGQSLALQPRPDVVREYNERIQDRLSKTSFADPSCRSWYKTKDGRITNNWPGTVVEYQEQMSQLQWTDYLIQGTGAEFMKKKKAACIARVKEEMPVSTTTLVLGLVMVAGGCYLRTTRGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3A6</accession>
    <name>A0A317V3A6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha-amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_579306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462179.1">
        <property type="nucleotide sequence ID" value="XM_025615260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3A6"/>
    <dbReference type="STRING" id="1450535.A0A317V3A6"/>
    <dbReference type="GeneID" id="37117403"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033934">
        <property type="term" value="F:glucan 1,4-alpha-maltotriohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004574">
        <property type="term" value="F:oligo-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000025">
        <property type="term" value="P:maltose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11333">
        <property type="entry name" value="AmyAc_SI_OligoGlu_DGase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000087">
        <property type="entry name" value="Oligo-1,6-glucosidase IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.400.10:FF:000003">
        <property type="entry name" value="Probable alpha-glucosidase (Maltase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1180:FF:000007">
        <property type="entry name" value="Sucrose isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF232">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 13 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="20"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="417"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY68516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="587" mass="68889" checksum="7C7ED1B52D58A6F1" modified="2018-10-10" version="1">MSKVASQIHRAWWKECSVYQIWPASYKDSNDDGIGDIPGIISKLDYIKNLGADIVWLCPSYKSPQVDMGYDIADYYSIADEYGTVADVEKLIQGCHDRGMKLLMDLVVNHTSDQHEWFQKSRSSKDNEYRNWYVWKPARYDEQGNRQPPNNWVSHFQGSAWQWDEHTQEYYLHLYATEQPDLNWEHPPVRKAVHDIMRFWLDKGADGFRMDVINFVSKDQRFPDAPVKDPRTPWQWGDKYYANGPRLHEYFQDLGKILKEYDAFSVGEMPFVKDTEEVLRAVRYDRNELNMIFNFEHVDIDHGTYDKFEPGSWKLTDLKAFFDTWQKFMYANDGWNALYWENHDQPRSIDRYAQAKEEFRTEAGKMLATVLALQSGTPFVYQGQELGMRNVPPEWDISEYKDIDCLNHWHRLLKHRPTDTEAQKSARAEYQKKSRDNGRTPVQWSNAPNGGFTGPNAKPWMTVNPDYVRVNAEAQVNDPNSTYNYWASVLALRKKYLDIFVYGDYELVDKDSQDIFAYTRQYEDQKALVLTNWTEGTLEWDSTANGVKGVKAVLLNSYEGADEVKERFSRQKWSLRPYESVVLLVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3N3</accession>
    <name>A0A317V3N3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_540553</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000050">
        <property type="protein sequence ID" value="PWY66800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461736.1">
        <property type="nucleotide sequence ID" value="XM_025612939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3N3"/>
    <dbReference type="STRING" id="1450535.A0A317V3N3"/>
    <dbReference type="GeneID" id="37115082"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY66800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="115" mass="13055" checksum="22A9979E631B1FD3" modified="2018-10-10" version="1">MASQTALSARGAYRQLLRATRVAFQDDVRVMIAARQEARRNFDSHRRHGIDTPMQINHAIEVANILKHNIVQGVREEGKEDAKWELRIHDDIERGDNDSIKIAGKKVKVDKPCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3Z0</accession>
    <name>A0A317V3Z0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_299865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462309.1">
        <property type="nucleotide sequence ID" value="XM_025606730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3Z0"/>
    <dbReference type="GeneID" id="37108873"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY68994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="66" mass="7709" checksum="2259125E80332C02" modified="2018-10-10" version="1">MPIMNIGHVSMAHREVLQRFYITDANVTYDYYVSKRIMTLTFSYVTFPRHRTCANIHAPDKTLANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V443</accession>
    <name>A0A317V443_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_527598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY69043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462358.1">
        <property type="nucleotide sequence ID" value="XM_025610392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V443"/>
    <dbReference type="STRING" id="1450535.A0A317V443"/>
    <dbReference type="GeneID" id="37112535"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016459715" description="Mid2 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY69043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="29154" checksum="0B8D6E6F0C871B79" modified="2018-10-10" version="1">MAIMLLTILPLTLLISLTTARTCYHPDKSIATSNVPCTSDSTTFCCDSGAICMTNGYCIGVGSQPYLLFRGACTDQDWGDNCPSHCANKNPTGGAPIIGIGSDSSGNSKYCCGFQVKNNGSSECVDGDTAFTLDDGEMILGKAALENVTSSSSSSATSTSTGTMSTATVVETMCSASDNGSHCGTSNATAVGAGVGVPLGVLAVSAAIWALWERGRRRTAVAAAVAAGVSGSGGYVMEHQVGAGGMQQNGHGWFSGRMEKTPLAELGHGNRGEVQEMMGSGGYRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V861</accession>
    <name>A0A317V861_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_477977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="MSFK01000042">
        <property type="protein sequence ID" value="PWY69208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462413.1">
        <property type="nucleotide sequence ID" value="XM_025608671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V861"/>
    <dbReference type="STRING" id="1450535.A0A317V861"/>
    <dbReference type="GeneID" id="37110814"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000266">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016193313" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="19"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="22"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY69208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="591" mass="64008" checksum="6ABEAA08EDDA5128" modified="2018-10-10" version="1">MKFGQGLLLAASATLSLANHQPTVDLGYATYQGSYSSSYGLNVWKSIRYAAPPVGKRRWQPPAAPLQNNSQITLAVDQPPVCPQSGAAGTPYVYGFNSGPGDEDCLYLNVYAPPNATDLPVLLWIHGGGYALFGAEYDPSPMMNTNNNGFITVEIQYRLGAFGFLSSSEVKEHGVTNAGLLDQRFALQWVQKHITKFGGDPKRVTIGGESSGAGAVMLHALAYGGQEFNLFNNVIAASAYSPPSYNYNDSVPEHYYKNFAELAGCGPNSTALSRYPTTFDCLVAAPSALLQNASGTVSTSGLFGTFAFLPVVDGDLIQERPSLQLSRGKVSGKRILVGNNANDGVPLTNPNVVTRSKFNDYVSSTFPRFTKSDISLLNTIYHTKDSQPVDNGPRYDTLGTSGPTALNQSEMATGLQQTVLNIFAETTFDCPAQWLAQAFSHGPRQAWKYQYSVTPAYHGADLAAYFSAGATWPDAGFRNAFQKFWGQFIIADSPVISLRDATANMSNASVPIGANGTIDWPQYSPRHPFQMDLNTTGGYLIHDVVTSNLSYWLREGDGIVNNFRLVNASSWEGGRGARCDFWRAVSERVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VBG4</accession>
    <name>A0A317VBG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_269697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462629.1">
        <property type="nucleotide sequence ID" value="XM_025606552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VBG4"/>
    <dbReference type="STRING" id="1450535.A0A317VBG4"/>
    <dbReference type="GeneID" id="37108695"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016404841" evidence="4">
        <location>
            <begin position="17"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="603"/>
            <end position="604"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY70338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="622" mass="67665" checksum="FC1A385DB45A38F0" modified="2018-10-10" version="1">MRAFWPLLSLAAVATAHDGPDLNLFDYGQRGPLLGTWLGIPGQNATFDYIVIGGGTAGLTVASRLVKSGYLSVAVVEAGGFYEIDNGDLSVIPEYMNFFIGPDPSDYQPLIDWGFLTQPQQSLGDRVLHLPRGKTLGGGSARHHMYYQRPTIGSLHKWAEEVDDESYEFDNMLPYYKKSVHFTPPDEELFTNSTNIQNPEAFSSSGGPLEVSSGNFVDGFGTWLRKALIALGLKQTEFNSGNLSGSGYSTLTINPSNAHRSSSETSFLQSTLNSGIGPVVYHKTLAQRINFDTHRVTTGVQVQTAGTFGTPSVNFTLSARKEVILSAGAIQSPQLLMVSGIGPHDQLSRFNITCISHTPGVGQNLQDHPMAGTTHRVDVPTVATLADDEALVESNVKQYIENATGPLSLPGPGYFGWEKLPKPYRWRLSNETIAALSTLPDDWPETMYTASGFAQTANADDKQIYATIVFADAAPFSRGQITLAGPNMTTPPIIDPQWLSNSTDMEVMVNAVKRSRQIWAELAELGVADPEEYLPGNNVTTNEQIRDFLRKNTITFSHASSTCKMGRKDDPMAVLDSSARVYGVRGLRVVDASSFPFLPPGLPQSTVYAFAEKIADDILHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VC37</accession>
    <name>A0A317VC37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_560356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462973.1">
        <property type="nucleotide sequence ID" value="XM_025614145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VC37"/>
    <dbReference type="GeneID" id="37116288"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY71575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="413" mass="45916" checksum="A28874DA4EC96086" modified="2018-10-10" version="1">MIPGHFASHPLESYVSPPLSPLAHWSLGLDPVRRGMDGEIRRMKQHDPQARFATRAGMSRRTADRFRQTGVPSARGDPSQATGRPRMPTYLDYGYTDSPFQGGPLQGEELQPYPPTLRDQQRQHHSVHQPLAPYDSEMVYNLSQQGPAQAPYEVVPPYAARQSAAMEALSSQFGVPQYFPPNEPTGTGVPPMGSPYLSLSPYNQPGSIGRSSATHVFPPAMENLTSVAAQQPLSPSQQQQQQQLPPPSRAGSESNGWKQLYAQFQHALRETFDSTRAGRLVEASRSLLQISEWLVANARDLGILRDDQMPHGDRLQIWNDFNICWLAVCQKQKDLAQEMLQTGRQPPQTSLLSGDAMDNLGKELIQICDRMEPHGLVDYQMGIWEEEILSIMGQCLDIVEGRPDVFGPPTASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCT2</accession>
    <name>A0A317VCT2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Molybdenum cofactor biosynthesis protein Gephyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_569157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenylyl-molybdopterin + molybdate = Mo-molybdopterin + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>molybdopterin + ATP + H(+) = adenylyl-molybdopterin + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:31331"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the MoeA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the MoaB/Mog family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463127.1">
        <property type="nucleotide sequence ID" value="XM_025614725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCT2"/>
    <dbReference type="STRING" id="1450535.A0A317VCT2"/>
    <dbReference type="GeneID" id="37116868"/>
    <dbReference type="OrthoDB" id="4349954at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061598">
        <property type="term" value="F:molybdopterin adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.190.11:FF:000002">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000011">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.980.10:FF:000013">
        <property type="entry name" value="Molybdopterin molybdenumtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="entry name" value="MoaB/Mog-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.10">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.190.11">
        <property type="entry name" value="Molybdopterin biosynthesis moea protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192:SF5">
        <property type="entry name" value="GEPHYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="MOLYBDOPTERIN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="MoeA C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="MoeA N-terminal region -like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="Molybdenum cofactor biosynthesis proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="9"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="MoaB/Mog" evidence="7">
        <location>
            <begin position="440"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY72174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="712" mass="74633" checksum="FD66D28898343E18" modified="2018-10-10" version="1">MADNILKAAILVVSDTASQDPSTDKVGDTLTTVFSTEGANNWGQPVINIVPDNVLEIQRAICDWTDGPNWVNLVIVSGGTGFATKDITPEAVSPLIHRHASGLVHGMLAASLKVTPFAMMSRPVAGVRDKTLIVTVPGSPKGAKENLEAILKLLPHACSQAAGANSRMIHAGGVKKLEAEAGVSAASPSGSKADHHHHHHHGHHGHSHAHDHGHGHAVPRAHTSPSERPQSNDPNAGPNRRYRESPYPMLSVDEALKIISQQTPEPAVIEVPVSIDLVGSVIAEDVYAGEAVPAYRASIVDGYAVIAPESQDAGPSTKGIFPVASITHANEGGTLTSLEPGTIARITTGAPLPPNANAVVMVEDTDLTSSTPDGQEEATVEILTGDIKPQENVREPGSDVALGSRILQKGDLITSVGGEIGLLAATGTKTVKVYKRPCIGVLSTGDELVEHNDPRKLQGGQIRDSNRPSLLSCLTSWGFPTVDLGIARDTPVGELEQSLRDALRGVGKAQKSIDVIITTGGVSMGELDLLKPTIERSLGGTIHFGRVSMKPGKPTTFATIPFKPSSSSSAQQQERETKLIFSLPGNPASALVTLNLFVLPSLHKLMGMEQRQITPAGISPPLGLPLVSVSLAHSFPVDAKRTEYHRAIVTASRKDGRLYAMSTGMGGVGQRSSRVGSLASANALLVLRPGAGKVEKGALVEALMMGPVVPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFG5</accession>
    <name>A0A317VFG5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Delta-9 desaturase isoenzyme B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_627644</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463391.1">
        <property type="nucleotide sequence ID" value="XM_025617439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFG5"/>
    <dbReference type="STRING" id="1450535.A0A317VFG5"/>
    <dbReference type="GeneID" id="37119582"/>
    <dbReference type="OrthoDB" id="4496439at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="15">
        <location>
            <begin position="58"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY73126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="275" mass="31460" checksum="A4028F6712291C62" modified="2018-10-10" version="1">MADAMADAMADPASHRSKNPPPLLHRIKWFNFTMLITIPLIAFLCTPYIPLLRPTLIWSLIYYLITMISITAGYHRLWSHRTYTAATPLRLLLALFGAGAIQGSIKFWARNHRLHHRYTDTPLDPYNITQGFFHAHILWTILHQPPHPKPKPTINITDLTTDPIIQTQHKHYLPLCITMGWLFPSLIAGFLWNDWVGGFLYAGILRAFFVNQATFCVNSLAHWIGGRPFDERKSARESVVVAMVTLGEGYHNYHHVFPGDYRCGRSGGMWMLRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFY6</accession>
    <name>A0A317VFY6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotide pyrophosphatase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_608541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463068.1">
        <property type="nucleotide sequence ID" value="XM_025616563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFY6"/>
    <dbReference type="STRING" id="1450535.A0A317VFY6"/>
    <dbReference type="GeneID" id="37118706"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY71832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="702" mass="79093" checksum="AB085F057D56D586" modified="2018-10-10" version="1">MPLRRNIPSSSLLSPGDYDEDAESLRSPSEQDSDSEDDEFLRRSRTTLELAEHDRTVLDDEEETEKLLTRSGPTHGLRRIFSPSSSSIRIGKQERRRQRKQARREARNVRRGRKRESAEIMFEMEEGHRDDERSLLSASSSDLDTRAKEYAYVQQPRRVSWRRLALIFSAIFVLLLIFWLGAYKASAKYRTPHSSRAMLYNGTALFAPTTILISLDGFRADFLTRGLTPTLSSFVSNGVSPQYMLPSFPSVTFPNHFTLVTGLYPESHGIVGNTFWDPVLEEEFYYTHPSVSMQPKWWNAEPLWMTAESQGVRTAVHMWPGSEAHIGGMDPTYLDQFNGSEVLSSKVDRILGLLDMPGIEVESDVAPQRPQFIAAYVPNVDADGHNYGPNSTETRGTISKVDDMLGSLFSGLEARNLTDVVNIVIVSDHGMATTATERLVQLEDLVDLDLVQRIDGWPLRGLRPKRPEDLKVLQEQLENVASNYSHAVEIYTRESMPERYHFQNNDRIAPLWVIPKTGWAVVERVDFDARKALANGEVYHPRGIHGYDHEHPLMRAIFIARGPAFPHEPNSRLEAFQNVNVYNIICDSLGVTPHPNNGTLRLPFQTVGLHSDEDTPTLDSPADPVPSTITGMTPTKMPSAEYSASASPSETAPEAQPEPDSESDDEEGPTWWGVLWDKFEEAKDWATDVFDTVKDNFTAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGU9</accession>
    <name>A0A317VGU9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_241775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463430.1">
        <property type="nucleotide sequence ID" value="XM_025606373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGU9"/>
    <dbReference type="GeneID" id="37108516"/>
    <dbReference type="OrthoDB" id="10536787at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="265" mass="29041" checksum="5905AA80D2B203E2" modified="2018-10-10" version="1">MSFRPCMPAMQSRALLPDSVSHRDCLSRASGDWSRPGDGQLTQPVPVGTHGPSRAPPRLLPHLERLENPALTSSPPLSFKPEARGESGAVKLHSSSIARFTPLSSIDEPVYSRGCVRSCTLACCRCWDDVIRPNHHAPAALSLPTYPRNIVQSRAYFDVEFRYRILSSLARSRLLYLSALSMKTRGRWTHCMLLSAIGNDFGSDASNTFASCLINVVMGGTKLSLSFGMNTLESLLCCDDQLLVGSRTPRHQLSPASKPCEDDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJ30</accession>
    <name>A0A317VJ30_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_539087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463462.1">
        <property type="nucleotide sequence ID" value="XM_025612624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJ30"/>
    <dbReference type="STRING" id="1450535.A0A317VJ30"/>
    <dbReference type="GeneID" id="37114767"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF84">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY73197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="642" mass="70989" checksum="8405E1BF03B3065C" modified="2018-10-10" version="1">MDNGAGKTVRLATSCTECQRRKQKCSREWPCNHCQSRRIAHLCKFTPKKVLKAKPASNERTLNTPTKNADSVPDSQASGSVASGEDFRMLGYLPDNLLKEGPEQYQSTVVSPSSQGFISSELEKAIRTIPPKPYTDMLVQHFLGEMNEQYSCLYPSTFLHDYAAWWSGKAGGQALAPEFTALLLQVCACATLYLDAEGKQRLETELGENSQNLAEQYHRTAKQLSNTIGPGKGGLTQVQQLFVNAVWYKTEALFVESWHALGAAIHEAQELGMHRSSTKAKVSEFEREMRRRIWCLLYTWDWQVSLLLSRPFIINSNYCSFELPNVRLEAEAGIDMPSPVIHIALQCQLGQAISKIPGVMSGILAPNQAIAIQQEIERWSDMFPPAYRRTNPDTRWDHSHSYVPMQRHQLHAVGYMVMFMPLKQCLTIDADPSKPSLEKSLQPMAVDCATKVMESARLLLAHLLPANGKFHFAPFLIFDTAAFLCSAVIHDRGRNLAHRDKAVETIGMGLDALEQISQGTKTGATCHSVLARLAGRMPLSPEEKVLLSSKTPGGSLEGPNTPPTVHTESVTFVNDDAFDAYPSNGLGVGFDMTLPAGLDPSGTIDGLAGLDDILNTDMGEISQLWDWDSLDLNIPGFHDYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VK18</accession>
    <name>A0A317VK18_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CoA-dependent acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_525261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463487.1">
        <property type="nucleotide sequence ID" value="XM_025610304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VK18"/>
    <dbReference type="GeneID" id="37112447"/>
    <dbReference type="OrthoDB" id="2548233at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42034:SF1">
        <property type="entry name" value="CONDENSATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY73222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="50838" checksum="66368992231948EE" modified="2018-10-10" version="1">MSWSQVSPTRWERPLTGFEEFLVLYANLSLTLSPTNQQYVFFTKITLDIHLPNIESALKHAWKQMRFEEPDLVTTIDKETKIYETPTTPTALQEWLDTTFIIITDITDADDLQRNGPLLDHDQAKLYYLPKTSDLVLRAHHSAIDGIGALIWWDKFFHALLHPHPHPEIPFGDEHHHLAIPIQSALNNNDPPTQEETNLATAMALHYVSHLPGLGMVSKAGTVAPGKCQHIEHRFSPDLTHAIVRGCKRRNISVTSAVHAAYIMVLMKHAADPSSNTSHYYASVNTFNLRGDLPERYRGKAAANYLVNLPFWVELPVGFSEVAGELNRSYRNDSRGMLGLVGAYNAGLARMLKTPEAQGMKVPTDAFVSSLGVVEKYISREYGGGAGVVTVKDFTFTVDAVLGMNMLHVSSFRDQLRLVYCFNDGYEEVDMIRGYLDDMERVLRVEVLGEMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKW3</accession>
    <name>A0A317VKW3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative snare protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_538692</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463728.1">
        <property type="nucleotide sequence ID" value="XM_025612540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKW3"/>
    <dbReference type="STRING" id="1450535.A0A317VKW3"/>
    <dbReference type="GeneID" id="37114683"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019529">
        <property type="entry name" value="Syntaxin-18_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15959:SF0">
        <property type="entry name" value="SYNTAXIN-18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10496">
        <property type="entry name" value="Syntaxin-18_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SNARE-complex protein Syntaxin-18 N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY74535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="362" mass="40385" checksum="B69267730026036B" modified="2018-10-10" version="1">MTDLTPTLTELLQQRQNTSKLSTGYMTTEIADEFLKEAYRINTHITSLLTYLQTIRPSYLSLTKPKSTTTTTTTSPSSPTPKSETLTDSDRDSITASTSTLLSNLSTSLRTLSSAESLRQETVSRTLDKKFKRSLLAKWADGKSLTTTDSNTEGKSEEEVLARETERILKCVRESILWYLSRKLGDVVNVQRDLVERRVERVRERERSVLYNLNSGSKAGKMGVGMGLGVDGMDGIGVGMAAKMDQDEVRAIEAELTPQQLQLFEEENENMVRYFEDVVGKVQNAEKSLLEISSLQQTLVSHLATQEEYIGQLVTDASNTRGNIGEGNKELKRATERRSAAQAVFWGTVGLCTWLVVWDLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VL90</accession>
    <name>A0A317VL90_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transmembrane protein 135 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_231439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463798.1">
        <property type="nucleotide sequence ID" value="XM_025606300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VL90"/>
    <dbReference type="GeneID" id="37108443"/>
    <dbReference type="OrthoDB" id="291792at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF19">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY74605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="58485" checksum="EBEAB7C4206D4FDF" modified="2018-10-10" version="1">MAPDSTPNPDCHAVVRNALRISLSAKEYKLLHESAIQQSPSAIRNKLPSPSRFEAIVRSKNKHNEAAVRASLRIFVLSSSLLKLVDVVTDRVRGDLSKKTTSRTSLVRSPNFRLSISLSLLLLFHRFLYRFFVKLRANLRTDDARPFRDRNPRISKALTSRYAPAVGASIAGFALGICPQNQLRLTAAIYTATRSLEFLFNALEEKGWFKNRPQWFGSWLLMPVACAQLFHAFVFDRETTPKWFGNVVLRLSPSYVRGRPDSLPLEIPWPEKEAVVDSLANIANLRWPAFASPILHPGSPNTLPSSLASISPITGPAHPAISSLSCALLHPTSPSCSTAFLHHILLSVPPLARSLTTVTLALSLRNIKSLMTEPITSINKLSTKIITLTAILSASSGSAWGSICLWNSLLPRSILPAKRFFLSGALAGVPFAFLGNSRSIFMYFFRAAVDSAWKTGVKHGLWKGWKGGELCIIVLAWALMGAILETRPSAVQGKGVRKALAWLKGDGFADPVEVAARKKARKAAAQKKAENEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPP8</accession>
    <name>A0A317VPP8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_524095</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463868.1">
        <property type="nucleotide sequence ID" value="XM_025610244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPP8"/>
    <dbReference type="STRING" id="1450535.A0A317VPP8"/>
    <dbReference type="GeneID" id="37112387"/>
    <dbReference type="OrthoDB" id="2017497at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032126">
        <property type="term" value="C:eisosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070941">
        <property type="term" value="P:eisosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052649">
        <property type="entry name" value="NCE102-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28165">
        <property type="entry name" value="NON-CLASSICAL EXPORT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="6"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY75241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="170" mass="17613" checksum="53F3B102F8491CE2" modified="2018-10-10" version="1">MNPLIIAILRGFQFIFSIIVLGISISLAKGQRIGSVPASTGYAAFTGGLGTLASLIGIAGVFIESLQTLITWAVDGLAGVAFVAGGITYAILLRGTSCSNILTIWDNTIISGGCRKVDKEKVCWSTPGEAKSRCTSAQADAAFMFLGFVVCVGVCGMGVLRRRKGGVGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPZ6</accession>
    <name>A0A317VPZ6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_577721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464239.1">
        <property type="nucleotide sequence ID" value="XM_025615186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPZ6"/>
    <dbReference type="STRING" id="1450535.A0A317VPZ6"/>
    <dbReference type="GeneID" id="37117329"/>
    <dbReference type="OrthoDB" id="2011986at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018810">
        <property type="entry name" value="UPF0662"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086:SF1">
        <property type="entry name" value="CU(2+) SUPPRESSING AND BLEOMYCIN SENSITIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28086">
        <property type="entry name" value="UPF0662 PROTEIN YPL260W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10303">
        <property type="entry name" value="DUF2408"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY76426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="459" mass="52444" checksum="965EDB2F1A50327F" modified="2018-10-10" version="1">MDSPAVPAPLDPREQPILERLLRTRDALLLLKQDKSSYIKSRDVLPLYEEVVAEVEKLNAARKEQDRRRAHNRLDYVLDDCFQLISLLFLTVGRNNEAPAVYSLATTVQRLLDHLEEAGFYSSKDLISITKTLANMNETLERCRQAYSPALITLLESRLEKCQLLLEKLQSGLAKLGPELAATHETLVSILRSTSAVNTRSKFSSFEVNGLRTQLKKLEDGMKDGKFVNAEGAPLPGAQEDVLLLKERCWIWTELVLERYAGMPAQWRYRANCRRQGKIDERFKEQYDRLIEIRNQLDRLAVTQAWSLRETDLFGYQRKLDRIDEARVNGNFVDAEDNAADIHAQRTLLYLIRRSYGYIYALLISSEPVSEALLPVYNQLQTLRKCLLEVQESGGVSNSRELYPYSMKLNSIDNMRVDGKFYVGSDIPEGQGSVNALLAECYDIVWELRAAVDEEDRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQX0</accession>
    <name>A0A317VQX0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proteasome component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_198479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464178.1">
        <property type="nucleotide sequence ID" value="XM_025606086.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VQX0"/>
    <dbReference type="GeneID" id="37108229"/>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="5">
        <location>
            <begin position="18"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="6">
        <location>
            <begin position="1316"/>
            <end position="1477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY76365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1863" mass="205900" checksum="3D79F03B134CD2B4" modified="2018-10-10" version="1">MATEATPASSEARELSLISKVELRIALADTDAKLEPLLNTYLAPLLLKLGSENLAVRNKVIAVCQHVNTRVQAPSIKLPVAALLKQFKEQKSQLIRHFDLIYIQQSIDRLGSDARVEVLLPLLQGISEIGTFGNQAAVVFNLVLRLLPLLKLPPKDSDDDVHLKSRLGLSDRDTRFLSAWFEKLLLLFPADKSSPTCPGLSPADYIFLNKGAPVNETWNPSSQGGLNLTETKVKALRFLASGAFSHTERFLPALIASADANSRLSDIGEELLKRFVPDLEAPDVVQQLYGLYFGAATPDGAPPARPALQTRILTFLGKSIRAIGDRWRVIRVIEEGLLSDAARSFKGLQAPKLRTQIFNFTTWVVRMGSPSDLEEMAPKLITGLRDFIQSQGWPSPGASGQKLPSTDLSLRGLAYESIGIMVPKANFAVYDGQESLSGFELIQWLFTSLNSDDSSSQIFVSIEQALGSILNSSIDSWDNDFHDQLRPFLVRQMNNYPGGEDLMTGFNVVRGPQYAAVRFANRFLPYNDVVARWIDLMAIASGSENRQEVTEEGRKGLHPFWHRLLRPSYDRQPATLASRDSTWHDFPKFSELSRFLLGSATSNGVSGLSASEIISGSYRNAFASTVSFIRSVLLWESLSASDTGIEIDQDWDTKLDVMLTSDEQARSSLKRYIRIADKEAIVLFLNSALAGLARESREGLQQCGVHFVNICSLASNEIVESVVPQTLVLRTSLKSNDQDIQTMAARAIGILASHPSLPENDLMTLIAECLDRIASWNSAIGEVALQVRGAVLALSYMLSRLAFRNMTIKVANAHVDQFVHTICEMLESARDSLLRRSAQVAIGQLSLSGILSYSMLSDVKWKPIREALVRDAKAESETAIISLGHLSLTFPEYGSDDSHFSALTGALYALHEIRSPEIHFTVGEALSNAAAGWNSKSLGPEFDVDEESPVSKVPESVVADVADTIIANCGAPKPSLKRASAIWLLSLIKNCGHLHPMQARLRKCQSSFSNLLVDRDEVVQETGAQGLSIVYSMGDQGLKDDLVRDLVNSFTENSSTLAGGKVSQNTELFEPGALPTGGGSSVNTYKDIMNLASEAGDPTLVYRFMSLASNNAIWTSRAAFSKMGISSIFSDSSVDGYLAKNPKIYPKLFRYRFDPNPNVQRSMNTIWRSLVKNPMEVIEVHFDEIMNDLLKSMLAGREWRVRQASCTAIADLLQGRQPEKYATYMDEIFTKAFKLLDDIKETVRVSALKLCQTITNAIIRTLETSDTDTKRADTMLRSAIPFLLSDKGMESGVEEVQGFAIGALIQMIRKSPGSPLRQFIPRIMEQFLNSLSSLEPQAVNYVHLNADKYGLTGQEIDKMRLSSIRTSPMMEVIERYLVDMLDEQSMKEFAAQLEGVLRSAVGLPSKVGCSRVLVLLSMRSMLFRPYADRFIQLLGKYVVDRNDTVSASYCTSIGYLLRLASDGRVLKTIEHAKELYLTAEDTNQRAISAEILQAASKLSNDRFMAFATTVLPFIFVSKSDLDEHVREVFEKTWQDNVGGNRTVSLYIREITDLVSNNLDSARWAIKHTAALGLAKAIMSLDSEIDLPTSEYIWPVLEKALAGKTWDGKEVVLEAFTKFSSQAKRLWQEKPTFSETMKTIAIREAKRNNPTYRPHALIALGGVSQARKDLELLPDAMSIVTRVLDEAEDQGEPMDVDSGKGQKPKQTLDDTLAACVTCLLQCLSPTSHTSAKTIHGHLETSRPVLHRAVGHGGRNVQVTLYRQLRALFDQIGTWASERSGESDLRGPQEPLAALAGEMFSQEIDLSVEAIRNERAQAVVAYVELCGQAGLPIDEALQLSLKSWREDERSGPVRQILDRALVKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VT03</accession>
    <name>A0A317VT03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_202962</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464254.1">
        <property type="nucleotide sequence ID" value="XM_025606108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VT03"/>
    <dbReference type="STRING" id="1450535.A0A317VT03"/>
    <dbReference type="GeneID" id="37108251"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY76441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="353" mass="39422" checksum="2A9B20CEC427A42E" modified="2018-10-10" version="1">MASAGGLTRRRGGGRVAGADENDDSRVSSPVSRNGSSLDNRIPETSFTSSENGHKIAFDPRDISETEERSKQPKLTLMEEVLLLGLKDKQGYLSFWNENISYALRGCIVIELALRGRISMQKDSSRRRFPLADRVIEVVDDTLTGEVLLDEALKIMKSSEKMSVNSWIDLLSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVADGGAKDDLHRRVRNVCSSRTVILPANAWLPEDVEFRYLRTITMVCAAYAANVLENALVTMSHEARERAFAQVDELLAEYSQWPFGRRAGGSQAIGANLAQAINDEVNKAKDRELQMEIVAACLSVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VT36</accession>
    <name>A0A317VT36_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RCC1/BLIP-II protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_549413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464099.1">
        <property type="nucleotide sequence ID" value="XM_025613444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VT36"/>
    <dbReference type="STRING" id="1450535.A0A317VT36"/>
    <dbReference type="GeneID" id="37115587"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="RCC1" evidence="1">
        <location>
            <begin position="294"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY76102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="426" mass="47761" checksum="97EE248034765C77" modified="2018-10-10" version="1">MELFGCGDNSAGDLGEPACCVRRYVNEPHRCQHNNDGKDSPYCPLWVLKPRQVFRAVRKIRVIYCENDADFFDIDGELKHRGDDPLKHHSLAEATQSWNINALVSAARLADGFIFLTEDGTLSTVRDTVGVQSFSRIPIQHIATRRVDYHNPNLISGAVAIVLKQDPQTVLSFDSWKPFCSFLESSEPNQAPTYTATFSSPIVKLTSRFAALTESGEVFMWGDDLPEQPPTPSDYDEDEWMDALFEHDFRHKPIEKWPSWEPKLLDYEPRRQPLPPIRTLSTGGVNDVAVSRSGQLFVWGYRTNKWPEIEDANDRDSAEFKEAFIPTADTALKIKSAAAGRNHIIVLAVNGSLWSVGEGLQGQLGIGLRQFGLCTEGNVIDMLANETDEEFAVSWERMDTEALVGRKCEEVFADGEHSLILTSSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VU31</accession>
    <name>A0A317VU31_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_523550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464275.1">
        <property type="nucleotide sequence ID" value="XM_025610222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VU31"/>
    <dbReference type="STRING" id="1450535.A0A317VU31"/>
    <dbReference type="GeneID" id="37112365"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF119">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="571"/>
            <end position="572"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY76462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="667" mass="74561" checksum="374FB3E2023BB82D" modified="2018-10-10" version="1">MTIPDEVDIIVCGGGSTGCVIAGRLANLGRNLQVLLIEAGEDNLNNPWVYRPGIYPRNMKLDSKTASFYYSRPSEWLDGRRAIVPCAHVLGGGSSVNFMMYTRASASDYDDFQAKGWTTDELLPLMKKHETYQRACNNRDVHGFEGPIKVSFGNYTYPITQDFLRAAESQDIPVTDDLQDLKTGHGAEHWLKWINRDTGRRSDSAHAYVHSTRAKYSNLHLKCNTKVDKVIIENGRAVGVTTVPTKPLAGRDPQRTVFRARKQIIISGGTLSSPLILQRSGVGDPEKLRRAGVQPLVNLPGVGRNFQDHYLTFSVYRAKPDVESFDDFVRGDPEVQKKVFEEWNIKGTGPLATNGIDAGVKIRPDAKELEEMKTWPTNDFYKGWESYFKNKPDKPVMHYSVIAGWFGDHMLMPPGKFFTMFHFLEYPFSRGFTHIQSADPYESPDFDAGFMNDKRDMAPMVWGYIKSRETARRMNAYAGEVTGMHPHFSFDSPARAFDLDLATTKAYAGPNHISAGIQHGSWSQPLEPGTSPASPTMLNSNKQETRESLQYSKKDIEHIEKWVQRHVETTWHSLGTCSMAPRQGNALTPHGGVVDERLNVHGVEGLKVADLSICPDNVGCNTYSTALLIGEKCAVLTAEDLGYSGKDLDMKVPEYHAPGEVTWLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUG2</accession>
    <name>A0A317VUG2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromosome segregation ATPase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_206258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464301.1">
        <property type="nucleotide sequence ID" value="XM_025606117.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VUG2"/>
    <dbReference type="GeneID" id="37108260"/>
    <dbReference type="OrthoDB" id="5423371at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF60">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2018"/>
            <end position="2043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2058"/>
            <end position="2155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2175"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1226"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1909"/>
            <end position="2002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2063"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2137"/>
            <end position="2148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="2208"/>
            <end position="2218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY76488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2243" mass="248494" checksum="5D71AACB99D43F9D" modified="2018-10-10" version="1">MPAHTRDGSRDRELVIRHQSVPMWDSSDPERAPPPLPMNPVATSPVTRGNVSPGIQAVAANFQEKMRENSPSPYTTNPMPPKSPEKSLIKGQFHRRMQSLQNTDARNEFLNYLESRSPERPLRASTMDQSPKQHELTPTNPPSSSDSRENEHEPPNLLISNRYLSRPILGESTPPSATMLALQNMQLPTESEPQPKSNDADPFIGPRRPDNHSFESLSTQIHSLTDMTSNLQREMAQLSRRSKDNATDLVSLKAATNARDEDIRKSLRELSSSLAAKFLDPDAATRWDFSTILGSENGINNRESDSSPSSKKSYSAPRMSSPNPFAAAMERELCGSPTPVSDGSASIALLEKVLREMATKEGQEKLQELVEEIKAMPASEAPRNDEIITKMLEEILDHVKDDPGSKALIRSPGAAGVPLQGNTDASDEHMYTPDMELMDAGNARGPERSLVLADGQMADEMLAIMKRVKTSVIEGGGMTNEVKALVRELRGEVLGMGRNLARQIEDVEASRAIEDRPDRPTHEELAGMVENSLHDLRGQLASIIDESRRHSSSISEFRAAMDGAEIYSIVKRALDELDLSYLRPEPQGVNMEKEEILETVREAWETYKPEIELQNFGLEREEILECLTEGLKEYKPQHEEAVTYDQVLAAVQAGMHSFEQPPSITKDEIVHTIHECLANFEPPAPRPLEREHFDGLRDEILQAVSESVTSQSALTRETLESGLGRDEILSALSEGLEAHFATAKETEHPHITIDDVANVINEAFIAQQSAVSTHVQPSFSRDDILNAIAEGMESQNSVTREIELNRDDLMEAISAGLQEANEANQSVGEQMLERVQEQLDGIKEEMGQHFSANERDSEQLLNAVKDGIAVVRQEVEGYAATASEASGKHEIMDTVKEGFRLLQADMEKTITETAMSNGPRGNPDTPELLDAMEKEFEHLRQTMSSLLIRNNAPNEKDEILDAIRDIAEQQKAAKNDEVLAAIREISEKETSTPSDEILASIREMLEQHKTMDNEEILAAIRETSEQQNNASSDEILAAIRELSEKQSNTQSDEILAAIREISEQQNNAYSDEILAAIREMSEQHKATNNDEVLAVVRDMSEQHKSTESDAILGAIREISEQYKPTNIDDITNIIKQEFEDLRHSMNTTLVRAEPTEPKTDKDEIIAALHESLEAFKDENNQPKEGGDNGASTGELMEALNDGVGTIREDLAKLLERPVEIDYSELLDELKEGLSSLKTDLEMLRQAQKENEEYETTRGGELVLARDSNAGNDIEGLKALISQLQVKVEAIESTPRGAEAPEDMLKKEHLDEVLLGLHELQSSVTGIVAREQPVDETTAKKEDTDAIETLLQNTKAQLDEMTFPAPDEIARAEQLESVEGIVKETKEAISELCTRFESECPTKSEIGTLETLMKDMWIALDEIKGKGAEEENDAEKLVKADLQTVEAMIFEVKTQVEELKLPDVETLPTKTEIQDLTALVTEFREKVDADNEMTGQAFDARKVEHAGLAEKIGEARAVVEGLGDELKSKLDGSNEGLTELKQLLEGLAASAESFTTVENVNELTELINREFERARGEQDATKLEKEERDAAAMVKHDETRAAIIVELGSKIDEKLGEIVAKYEEAQSAIETSLETKFSESADRDNAHLEAVTNTKALAEDIKLVIGTMGNSVNEACERMCADAQTFFEKVDVSYNKMEEMHNEVKTQQEQARSDLERAAAATDRVESQLHEFHPQVLESIHEILSIVGQHYDHAQQSAQDIRMELSTIPSAITPLLPALPPPEPEKYDDTQVQEKLNDILDRAKNSQVQETLNTLVERVTNNQVHEKLDELLSQTTSTNGQVYEKLSELLEHATNSNGPVHDKLDILIDHATNNDQSVTQMMKLDEMHKDIMDTSRRMNEMFAAQTAMVAEDNERRRKEAEEAAIALERRNTQREQVEAEIMTLKEEKDSLLKILQSLKSEKDDLAKQNAKLNKEVAGLEMALELRHEEMQVMEERADSLEKRILEGVLDHARSVLLSRPNSVKKGRGSRARGPSATSTASTAKEARNLLSSSVGLALRKRAPTGSQAGSVAPSTPSKERRIFSLSNVTGNRGAGDRQVSATSGFASLKRSHSVRSNASQRKASWGGRSSIANKENEVFAEEDGEESDASTERRTSYTGTYADSMIYGTNSMVSADRRVSAASSTGLRSVADEREGSDEEDAQTTKADEADEDELDLDEEGSKMVLYGQHSDSGLGPEVTSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWB6</accession>
    <name>A0A317VWB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_548863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464577.1">
        <property type="nucleotide sequence ID" value="XM_025613422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWB6"/>
    <dbReference type="GeneID" id="37115565"/>
    <dbReference type="OrthoDB" id="5368934at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016403504" evidence="2">
        <location>
            <begin position="17"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="523" mass="59238" checksum="80F42462D371D78D" modified="2018-10-10" version="1">MAFFFLLVFPPPLGLSQATLGAATIRSSENISLPALSSACTSRNSRWKNIQIIGKLPCLVRSSGKTLKHITSLSMTALKPVSEPLLCFFLTIIPIFVHIQNLIILLEEEEDEENKPLHERFPFNLEHEQNTHVPAADSDDPVTERPQRRRFSMSDIFTGAPLATARVVELSRRPRSQSRDRSQPLASGASVSSSRSSSLIRSALSKMACIISLDSEIETESEPIQLIPADEATPEKPLMEFRGSETWPRLADDRRLLGIDVFWPQDLDETDKNTNSEESSGKKTKPKPVILDVEQMSPISHFRNLRSLKITGMMQSYQKYIWQAAWLNPNLDELELGMALPPCIRKDRTGDWPYMKGGWKLNPAHYAEPVYYGDGSGALDRKLGQAEYHDKMVIEKAKVCAMAMGRTRQKLAIRTLVLFGFVVDADPFLHWFDAKRLKCINFKDYCVDAGFWLCQPMKKVKVVFPHQVPEKAVVARQVDLLSELKVIELKGGKKDSLIPRVRYSIDPHFNNLMRNDLRCDMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VWP5</accession>
    <name>A0A317VWP5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_558890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464521.1">
        <property type="nucleotide sequence ID" value="XM_025614034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VWP5"/>
    <dbReference type="STRING" id="1450535.A0A317VWP5"/>
    <dbReference type="GeneID" id="37116177"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF647">
        <property type="entry name" value="ENOYL REDUCTASE (ER) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="328" mass="35540" checksum="E70AB5204A22E594" modified="2018-10-10" version="1">MASRTARTLIQPTAESNTEDLTLTSHVIPTPNLTKNEHLIQVHACSPCAGELHWPRNFPPPQPRDLIPCPDVSGTVVSAPPDSPFQPGAEVYARTNYIRPGNARDYTIATTDELALKPRGLSWVEAAAVPVSAETAWQILFIHAGVVSPDAEMDRILVTAASGGFGMWVVQVAARVLGVEVVGTCGSDNVELVRSMGAKEVVDYRATDLKVWVEQETGKRVDVVIDCVGGRALQDAWWAVKQGGTVLSIVQPPEGVCPRSEKGGVKDIFFVMQPSGKQLGMITELIEEGKCRGLVDSVWPLERFRPAFERLDTGHTCGKIVLDLALNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VXX4</accession>
    <name>A0A317VXX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_626523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464798.1">
        <property type="nucleotide sequence ID" value="XM_025617362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VXX4"/>
    <dbReference type="STRING" id="1450535.A0A317VXX4"/>
    <dbReference type="GeneID" id="37119505"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF5">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE ABHD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="103"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="408" mass="44496" checksum="901709BC9152E72D" modified="2018-10-10" version="1">MAWYSQTIETLSDSLGNTRTQLPLLAVTGASFTLGLLFRSLLSDPQLETTVLDSPRKNILSVSDAVSREHPLPTDVLPGARDVSTPYGSMRVYEWGPEDGPKILLVHGITTPCIALGGLAHALADRGCRVMLFDLFGRGYSDCPSDIPQDDRLFTTQILLALSSSALSWTGAGSDRFCLVGYSLGGGIAASFASYFPQLLSSLVLLAPAGLIRDSQISFQSRLLYSRGLVPERVLGFLVGRRLRAGPLTSPKPKSKTISAEDALAEELPTQGAAEVQRLSRTYPHVNVPNAVKWQVGEHAGFVHAFMSSMRHGPILQQRQRDTWERLGRYLSGQKDLSLDEQRTNGLPSDKVLIMCGNNDAVIIKDEVVPDATAALQGHASFRFFDAGHEFPSTKYEEVAQYVMEFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYR2</accession>
    <name>A0A317VYR2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_472703</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464664.1">
        <property type="nucleotide sequence ID" value="XM_025608449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYR2"/>
    <dbReference type="STRING" id="1450535.A0A317VYR2"/>
    <dbReference type="GeneID" id="37110592"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="77"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="647"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY78152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="784" mass="84550" checksum="82C80AB9E8AE11A9" modified="2018-10-10" version="1">MNQMNVAGMNPGAGGPVGGVPMINNGSAAPRNDPNINNIPENMINNLNTYIYDYFLKRGYHECARALVKDDSIKLNTEPSIKTSPGHRRDADVNGVDGDTMMTDGKDGDKLKIPDDLPRPNLPSEGQQSSFLLDWFSLFWDFFWAQRKKGNSADVRQYLQHTQNIMRLREQQHNQLLRQQPLIPGQMAQMNMRRSNMVAPNLQKTVLQNNTSGLSQQQLAQMHKNQQVQMMQQMQREHSDMDMNGHRPQSPSSAENAPSPSKRPRLEGGPMNGQQLVPNGRGQPQGIPNQQTPQAILMQNGLNRAMNPNSFQAFPQSGQTAQSKQMQVYAQNLAIHHTRSALTNQGMPNGMMNPGVMPTQTDMVPMPDGQVYPINGDYYGNGQMAQVRTGMQTPGGQHGNHALQDYQMQLMLLEQQNKRRLMMARQEQDSMARPDGQPPMPGQQQGLPPGTSPQGSRAGTSPNPNDQMKRGTPKMPQTGLPGSPSAADAMAQGRGSPLNFPGAQMPPEMGGPQFFVKNMAEGMAGPNGMRPPSSNPAFTGPQMGQPITAGAANRMPNGGWQPQQGVQGQPMAPQPSPVAQPQSTGTPQERNAMPPPQAPPAPGANVGRTQPPSPQTAAPPTPQQANKPAPKKKDQKDSRKRPKKGSAAANAAAQANTAATPSSEAEHPPTPTPSTPITPQHPNSFNKAGTNATTSAPPQPTSAPAPQPLVQQPPDQTQQPFNDLSIPDASAFNLDFSALENPDILENFDFDTFLNTDADTAGFGFDPNISYPTDGVETGAGDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYR9</accession>
    <name>A0A317VYR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_558972</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464619.1">
        <property type="nucleotide sequence ID" value="XM_025614038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYR9"/>
    <dbReference type="STRING" id="1450535.A0A317VYR9"/>
    <dbReference type="GeneID" id="37116181"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053230">
        <property type="entry name" value="Trans_reg_galc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47654">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="104"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="146"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="835" mass="93708" checksum="403B7BBBCA141126" modified="2018-10-10" version="1">MESTPGSYPFGVRTADENTLALESENPTLRGISEWPWESVSPSGVPPVAFRPYSLPRYMDRPGPYPYQSSSSSSREVSGPAAKVAIPRTTSASSQSQRRRSARACEPCRQRKIKCDGNKPVCRQCIDHNVSCFFVDVKRVRDQKQLGFLGKKVEYYEQLLQDLEREVDENAARRIRRALKASDPSSPTDDDGDSDSSTSSIGSLNALDLVEEDLNRSEKSVATGFFGKNSEVAWMQRLEDEAEYRSRRMDGSLEGEGEDEGEGEGKAGASSPPHHGSARQETAIAAMSYYLDDLSIPLMDSVDPYALPPKELANRFFTGYMESVHPSFNVVRKTAFVSQYRQFFSQPTKPPQRWLAILNMIFAIGCRYCQAVTGPGDGDYNDLVYLNRARLLTLGESVIFEHADLQQIQVEFLVALYFVSMCQINRAFKFSSMAFRSAVSLGINLRFVDDRTQYPAKEARSRLWWSIFLLEHLLTAITGRVSCVGESLSATPLPIPFEEEAFGRPEVLPLLQDSSLRMNRLKLTLLQTDEEARASASWLATCEPSPSLFFHCTVDLATITQAIINKVYSIQGLRDRASQVEQRIRKYCSILDIWVSKVPEAYRFTSGNSDHLDMPDNNHTPWMRERLSLAISYYSARITLCRPCLGHTSLQPGSLSPDPIPPSSLRRLARRNSRNRTHFSSDMALVCVISARSLLSTLPETPDIVWLTAVTPWWCILHYIMQATTAILLHLSSWPPGTASSEDPSRPAASDMLSMVRAVKKALRWLHHMARSYAASRRAFRQCHSVVRRIAPSLRLDISDLPDGRDLPVDGDESGLQDDDIDSYTGDLMEFDQVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZ03</accession>
    <name>A0A317VZ03_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_188541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464670.1">
        <property type="nucleotide sequence ID" value="XM_025606024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZ03"/>
    <dbReference type="STRING" id="1450535.A0A317VZ03"/>
    <dbReference type="GeneID" id="37108167"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY78158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="252" mass="27899" checksum="F82D6DD85A97FD9E" modified="2018-10-10" version="1">MHLHTDIDPSTIINISAASTTTITKPTTSTTRTTTTTTLTAPTSIPKQQNPFYFAYGSNLSPTQMAARCTVHPDTSIPLAIARLPKWRWLIHQRGYANVLPPHELRIGGQLHPDAEQVPVAGEGDAVYGVLYDMGKEDERILDGYEGVDWDAPVAEGKGGLGLDVRPREQGRGCYNKWVVEAEVVSWIGAGDGREKRETVPVLVYVDERRVRMGPPKAEYIPRMNRAIRESVDLGLPARWAEEVMRPSIPSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZH7</accession>
    <name>A0A317VZH7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_426427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464487.1">
        <property type="nucleotide sequence ID" value="XM_025607444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZH7"/>
    <dbReference type="GeneID" id="37109587"/>
    <dbReference type="OrthoDB" id="4259138at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY77300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="334" mass="36553" checksum="18F243671F659B24" modified="2018-10-10" version="1" fragment="single">AKSSRASLKKLFRYSVVSEAPGGCSEYGLDALNAMADDAYTLAKEGLQAVKDSQDTSAATYAEADRLMAAMFLNPSSKRINGVKGYLENGGNTDNGQLTNRPFLLCGDLWRVRQDMSSQMRDSTGTLMEEDGKAIKISDIPAMVERQASVAKKEGVDPSLIYPYWSDATVSYTWDLKYGDGDPTIGPCQGTTDAIAFTITEPPVGIVVLCPKTFSGGRLHSVAAEPVVDTSFYSSKPPDDVTVQRIKAIIGPGSVLYHELFHLYWGQSRTTPSGNEEYSFRRMTGKSSSRSFTTADALKNPQTYAYMSLAYDYTLNVKSGSYPVEFYNGWATYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VZX4</accession>
    <name>A0A317VZX4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_558852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464861.1">
        <property type="nucleotide sequence ID" value="XM_025614031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VZX4"/>
    <dbReference type="GeneID" id="37116174"/>
    <dbReference type="OrthoDB" id="550558at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844">
        <property type="entry name" value="SER/THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37844:SF2">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_1G14840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY78552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27539" checksum="FE5C77ECF784A2EA" modified="2018-10-10" version="1">MLQKVWSFFQSSISFQVLSDLHPEVNRQYPSYETPGWTRLDKARQLEREPSLNGPLIVFHQKRFDIPGSCVTILGCTLWSKVPYELTDVISKKIEGWSVDDHNASQDSDLAWLLEEIHLIHKENEKAENRSKKRSILVVTHHAPLLQRTSSPQHAQNPWSVAFETDILSQTPDGVVWVFGHTHHTTDFKEGGVRVVSNQRGYVLPWNNSKTQDSFDLRTVIRVCRFTCTFQSLAYNHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1I6</accession>
    <name>A0A317W1I6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dUTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_184194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464542.1">
        <property type="nucleotide sequence ID" value="XM_025605996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1I6"/>
    <dbReference type="GeneID" id="37108139"/>
    <dbReference type="OrthoDB" id="2874071at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42680">
        <property type="entry name" value="DCTP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42680:SF3">
        <property type="entry name" value="DCTP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22769">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY78030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="170" mass="18282" checksum="1656B7DD256500D1" modified="2018-10-10" version="1">MILSGREVLARQLVLNLRHITQQQPCGIDLTLRHVSAWTSAATIDFDNTKRQASKTSILAFNRTNNAITLNPGAYLVDFNETVQIPLNCMGSVFPRSSLWRSGAGISAGVVDAGYEGAMGALLEVKNPHGVVLYRDAKLAQIVFELGVTVEGHKGIYQASRSSVGRDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2P6</accession>
    <name>A0A317W2P6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenases/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_537556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465089.1">
        <property type="nucleotide sequence ID" value="XM_025612299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2P6"/>
    <dbReference type="STRING" id="1450535.A0A317W2P6"/>
    <dbReference type="GeneID" id="37114442"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY79517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="288" mass="31630" checksum="4976AF1CB8763E73" modified="2018-10-10" version="1">MTKTIVATGTSSGLGFEAIKQLLQQSEPYNFILGARDTAKVQAKYDSLNYDTSKHTITIYPLDLLSLKSVQSFAEKVLSKLGSKQLAYLFLCAGTLDNASGPGPNGSQWCEGYVVNHLAQHYLLHLLRDALSASQSRVVVVSSGAIRSVRDQDPATLDVDLKANSKAGYRAVYSASKFVQLLGAIYWRRELPSCTVIAVSPGLIPSTKLATNMGLTMDMPDAKSISEGAQNLLRAFFVNDFPSDPEQIFLTSWGEWWSMDVYAMALDTDLQQKWCLSREEIEKAEGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2Q6</accession>
    <name>A0A317W2Q6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_588109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465099.1">
        <property type="nucleotide sequence ID" value="XM_025615868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2Q6"/>
    <dbReference type="STRING" id="1450535.A0A317W2Q6"/>
    <dbReference type="GeneID" id="37118011"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF32">
        <property type="entry name" value="MISCELLANEOUS ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY79527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="642" mass="70931" checksum="7B9A650F225288F0" modified="2018-10-10" version="1">MASTTNSTTAESSDAREHESPQDDTYAAPYGSSCVNCSQAKCRCIYSKAGGRCQRCQRLDKECRPSATRRVTSRKSNVSKNTPKTTRLEDKLEDLVSLLRAGVQPGNISTTMLKHLAQPSDNQKPTSNAASPLGPSDTSISSSRPGSVYAPHGNGAASTPEASLLDGGSISSGTSAENEMEPTGVQAEGYLTFYITQMLPFFPCMYIPPGTTSQKLRRDRPFSWLCIMAVACKSSAQRRVLFDRIKQIAAQKLVHEYSCRDLDVLQGILIYLGWSNQQVYNKANIYVFAQLAMGIVYEMGLFNPEAKGKHMLLCVHTEPHENRSEAPRNLMDERRAVLGCFLLTSIFATFLQQSDSLRWTPHMDECLRLLEEQQECANDGILAQQVRLQLVMDKLSLGRWYGGSSKSLESMRPSPTIYLRPMQTQLQSQLQAIMNRLSSNSKGYKIVLLHHYNTSLSLHESALTKGAIASMSNVTFEHLDYLYGCLDATKSWFDVFLSIPPMEYIGFPFAVFSQMVQNLATLYQLSTLESPLWDTANVRRTADVLQLLDTIVANMDQVASLNGLVGDPGGDIFSTIAQMYRAVRVGWETRLEPDPGSSATNIIPSLPIATLPGPDPLSAAFPPMDNNDWLTDMLNTMDQANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W2U4</accession>
    <name>A0A317W2U4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_537198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465184.1">
        <property type="nucleotide sequence ID" value="XM_025612214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W2U4"/>
    <dbReference type="GeneID" id="37114357"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY80325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="79" mass="8871" checksum="2E8A73F2EEF07F3E" modified="2018-10-10" version="1">MTLTSMLSTQNASSCRAINSCFSCLVFAPRNLGIIKARGVSCWGSMLQVRILGREKPPDKVRPLGRRWSKHKNSLFQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W311</accession>
    <name>A0A317W311_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_521344</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465254.1">
        <property type="nucleotide sequence ID" value="XM_025610144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W311"/>
    <dbReference type="STRING" id="1450535.A0A317W311"/>
    <dbReference type="GeneID" id="37112287"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY80395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="507" mass="55446" checksum="B8CE62A8ECF79777" modified="2018-10-10" version="1">MAGPNKGPRAMSIEDPPIPSSHQYRGKPRLERYLGFLPMLAFAATLQASWESLGSSLYAGLLNGGPVAIIYGMILSFTGSLSLTLSMAEMASINPVAGAQYHWTYELAPFAPRFLSFIQGWITVIAWWANVAVGPYLVGTEIQGLLVQNYPSYVPQGWHGTLLVFAVLALPLLVNIFARRLLAPVEVLSGVIHILSYPAIMVVMIVLGQRHTNEFVWTEFVTDQSGWHNSGVIYSIGLLTAAFALSSFDGVIHMSEEVNDAPRAVPRAMVWGLVLNAILAFGFAIALLYTMGDFQKALNSATGYPIIEIFYAQTGSKAAASAMMLPILLSGCYSSFNVLASVSRLTWAFARDEGFPFSSFFAYVSPRYKIPLRSLFLVTTITILIALINIGSSAAFNAVLSLDTLALYISYLVPVLFMLIKRIHAPGDINWGPFTLGRFGIPINVFAVLYGTYITIFLPWPETQPVTASSMNYGAPVFGIALLFAVIDWFVRGHKKWNGPTVMPEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W337</accession>
    <name>A0A317W337_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_153744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465566.1">
        <property type="nucleotide sequence ID" value="XM_025605824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W337"/>
    <dbReference type="STRING" id="1450535.A0A317W337"/>
    <dbReference type="GeneID" id="37107967"/>
    <dbReference type="OrthoDB" id="5593278at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018788">
        <property type="entry name" value="Proteasome_assmbl_chp_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053720">
        <property type="entry name" value="Psm_Assembly_Chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31051:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10178">
        <property type="entry name" value="PAC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="151" mass="16459" checksum="D2AD1C5A42D2F23C" modified="2018-10-10" version="1">MSEPFDLNLNLPFPAVTKQVAGVIQDIQTNVTLVKFSDRILITISQKGRLGHWLHVPLENKNPGTEGFHTISDFADDSLLPIGNLTATSLLGGRAPGHEIVGQLYARQIASAIVTKTPNEKRMLVLGLGLETADTDRDVFFAIIDLVLQCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W4Q9</accession>
    <name>A0A317W4Q9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_536866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465674.1">
        <property type="nucleotide sequence ID" value="XM_025612134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W4Q9"/>
    <dbReference type="GeneID" id="37114277"/>
    <dbReference type="OrthoDB" id="3204049at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY81606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="335" mass="38248" checksum="2A5A1BC5D02A5440" modified="2018-10-10" version="1">MHLDHKIPWNTAATHVTYIKNNPQFTPRRTDLFTRSKPSESTDLNHFRRTLIRTIREFSTTEESKPLKCIPLDNLLSDDLLSYPEQHFNLGSHTTNSALNNPLSSQHRNIQYWIDRAGTPPTSYVSGDGDLADAVKMLIIIAGSAKKGDEKSKEMSREAISVLLTLSRHPQVPLHTLASIHWGHAFGVELVADTALTVYILINLMDRVVSNKRDDNEASVLETRTFQYWAGNALANYDYPAQNIPHRRFWTGLGVTEEWVYQQRGREGLPTVGGTDPLKGETEDIRSGLQQYLKTCFAILYVYDMLLREWYGSEAADEKWEYRIGCLFESWGCRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W745</accession>
    <name>A0A317W745_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_625963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000021">
        <property type="protein sequence ID" value="PWY80838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465440.1">
        <property type="nucleotide sequence ID" value="XM_025617321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W745"/>
    <dbReference type="GeneID" id="37119464"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY80838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="161" mass="18960" checksum="06690D122FB6A24F" modified="2018-10-10" version="1">MSGTLDLYITIYEEENRPSHWALFFDDGSLNDKTLLSVKYDHRSHLKFHTETRNPRILYNQDELILVGTFNATDISKVNAIARGIRPEDLHIDRLNCIRYVRDVLDTLEVNRIVGNEVVYWIQKSFIRARMEKGEVDYEVECLVRKRRRDTPVVITYGDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W774</accession>
    <name>A0A317W774_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_547814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000020">
        <property type="protein sequence ID" value="PWY81531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465599.1">
        <property type="nucleotide sequence ID" value="XM_025613356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W774"/>
    <dbReference type="GeneID" id="37115499"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY81531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="189" mass="21745" checksum="D2E0ACAFDB5A7B3B" modified="2018-10-10" version="1">MASHFETRPPSSNLVPLMEEEDRRVRDLLHACILVPLIYQLNSTWAFENLQTFMRIMMTLGQSPICDRNVTHEPYLSYQRLILDHMIALRHILQRLLILVQDHQNGIRSSPVSAGDITSLTPTYTQVMVSFDTSLRTLAHFQKPVSLFYPWLGPDEIDRADAYARDLLNTVPESVYELPQPGITELPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WAW9</accession>
    <name>A0A317WAW9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_536532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465840.1">
        <property type="nucleotide sequence ID" value="XM_025612036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WAW9"/>
    <dbReference type="STRING" id="1450535.A0A317WAW9"/>
    <dbReference type="GeneID" id="37114179"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016340565" description="Magnesium transporter" evidence="7">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY83055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="13515" checksum="F98B95B21818718E" modified="2018-10-10" version="1">MGFLSRLVAFFGLILLAHAGYSAHEHTLLYSNSSTTNPTALPLDIIIEALASLVLVSAGLVLGAEKLKPISWSEWAGEIEREGGGRNPFLRLEERYGFWDVRTKRKEFADWMRGEVPVPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WD07</accession>
    <name>A0A317WD07_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_468625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466109.1">
        <property type="nucleotide sequence ID" value="XM_025608262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WD07"/>
    <dbReference type="STRING" id="1450535.A0A317WD07"/>
    <dbReference type="GeneID" id="37110405"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="173" mass="19593" checksum="34B80D9B658A4112" modified="2018-10-10" version="1" fragment="single">KIQIKIITKLGVGLFLCLSIFIFVCAIVQDSGTFYQSTLDYPWKDFWLHIKAYIRVTMGSLTAYQSTLVSDNKASDKMKAGLYKLTRLIHNLRVSLRYPSQPGGNEIRAATGKPMLFPSIPRPTLGTLRAWLGNRTERDFNSLQSYSYPLLDQTNEHHDFIRPPRVAKGKGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDS6</accession>
    <name>A0A317WDS6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_495081</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466359.1">
        <property type="nucleotide sequence ID" value="XM_025609250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDS6"/>
    <dbReference type="GeneID" id="37111393"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="76"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY83891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="588" mass="63743" checksum="14662FC3478D1E03" modified="2018-10-10" version="1">MGETSTLTRRKSLPTNSPDEPEKQDIIPAPTEDPDERQKGECNPVKSAREAQQPNLQPPQNDLSLPPPKTWRFWAVFPALCMTTFLAALDTSILSTALPTIALDLHAGNLYMWITNSYILSSTVVLPLFGQMANIFGRRWMMISSVVIFAVGSAMAGGANNVGAIIAGRTVQGIGGGGINTLVDVVICDLVPLRQRGKYVALMASVWAVGTTIGPVLGGVLAQYVSWRWVFLINLPLCAVSLLLLVLFLRVTHPRSPGTIWQQLQRVDVVGNTILTMAVVAILLALTWAGTAYPWSSGRVLVPLFLGLAGLVLFYGHQNSRFCPEPSLPLPLFSSATALCALWISFLQNLLLYWVGYFLPIYFQAIRSLTATESGVHVLPITGAIAPFGVITGILIAVTGKYRVFHFVGYTCLTAGSGLLALLNRHSPARDWAGFQVLFGVGSGMIFSSTLPPIQATLPESDVATATATWAFVRSFGCIWGIAIPTTIFNTRVQALLYRVSSQALREKLANGGAYALASDGLMRTLSDTPGLEAEVLGVYEESLRWVWWMAIPFGVVGLILSIPIKQLVLSEELHTEFGLQEVSRAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WE72</accession>
    <name>A0A317WE72_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_536307</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="6"/>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466639.1">
        <property type="nucleotide sequence ID" value="XM_025611986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WE72"/>
    <dbReference type="STRING" id="1450535.A0A317WE72"/>
    <dbReference type="GeneID" id="37114129"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF12">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="35"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="299"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="8">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY84714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="421" mass="44083" checksum="811571F9A979B266" modified="2018-10-10" version="1">MSSAQQRLTSIANQLSGPGAASAKQRLLSKTPDDIVITLAIRTPLTKARKGGLKDTSLDDLLISLLTSIREKSNLDPSLVEDVCVGNVLCPGGAYVARSAVLAAGFPATAAASVANRFCSSGLLAIQNIANQITAGSIDVGIAVGAESMSNNADGGAPEMSSQILTHPIASQNTQPMGQTSENVAGQFNITREMQDRFAANSYQKAERAQKAGWFNDEIVPVKTTIKDPKTGEVKEIVVDRDDGIRYGTTAESLGKIRAAFPQWKPSATTGGNASQITDGAAGLILMKRSRAQELGQPIVAKFCGATVAGLEPRIMGIGPSIAIPKILSKFGLNKEEVDIFEINEAFASMGTYCVQKLGLDEAKVNPRGGAIAFGHPLGCTGARQVVTALSELRRQNKRVAVTSMCVGTGMGMAGIIVSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WEK1</accession>
    <name>A0A317WEK1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylate 1-monooxygenase sala</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_468571</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466125.1">
        <property type="nucleotide sequence ID" value="XM_025608255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WEK1"/>
    <dbReference type="STRING" id="1450535.A0A317WEK1"/>
    <dbReference type="GeneID" id="37110398"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="167"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY83657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="440" mass="48561" checksum="60933B7E052BEAF8" modified="2018-10-10" version="1">MAAPKKNFHVAIVGGGIAGVTLAIALYHRNISVTIYEQAHEFAEVGAGVSFSPNAVQAMNFCHEGIYNAFEKVCTRNLWPTKQKVWFDYLDGYKKVPNPASGGRQDIEFTISNSLGQNGVHRAHFLDELIKLVPKGISRFNKRLEDIHERISDGKLILKFADGSEDEADVVIGCDGIKSQVRQIIVGADHPSAKPSYTHKYAYRGLVPMDKAVEAIGEELASNACMHMGPGGHMLTFPVNAGKTLNIVAFHTTTDEWAEYPRLTRQGTRDEVLRDFAGYGPNVMNLLKLTDPELSVWAIFDLGDNPVPTFYKGRVAISGDAAHATSPHHGAGAGFCIEDTAVLAALLEDKRVQTHKDLQAVLAAFDENRRERTQWLVQSSRFIGDCYEWRADGVGSDFKKIEEAINYRNGVIANVDVGQMCEDARKQMEKRLNAVEKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WF64</accession>
    <name>A0A317WF64_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_468616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466106.1">
        <property type="nucleotide sequence ID" value="XM_025608261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WF64"/>
    <dbReference type="GeneID" id="37110404"/>
    <dbReference type="OrthoDB" id="4325529at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY83638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="80" mass="9364" checksum="157A6265BD58C108" modified="2018-10-10" version="1" fragment="single">FLKEEILNREIRSCRYKKPRIIEGSKPIIRTLGKNAVQSYISAIIDLWSYQRSSRINPNPNPRGETVTILLADYIHCEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHK9</accession>
    <name>A0A317WHK9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_103424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466483.1">
        <property type="nucleotide sequence ID" value="XM_025605470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHK9"/>
    <dbReference type="GeneID" id="37107613"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01419">
        <property type="entry name" value="Jacalin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="639"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY84558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="786" mass="86644" checksum="E44FD9FC4C0584AD" modified="2018-10-10" version="1">MPLFKQLRRRSKANFHTKSTETKSNESQSNGELNSGKSSTTPDTASYSSLTPPSSIKPNLSSPNLPSLSESNGASTNAVSPLSVPPQRPGLLTAPSQRNSAYFGSNMSVNGAVRSPTPSSPYAPRIISISDNSWVHQKVLLVYGQIGDPRQHPLDGTVTVYHHQDSFPSVAWPVTSSHFKTLVHLVPGPNRLRFEFVSAKHSSGSAHPTTHTSYICINYLPLVNTPPLHLVILLGKDSDGTFDAVPERQQREGNGLETAIQKYRMAAYLWQAFTGEQMFRNNFGRRCFRFEEEWQAGTLSRRDAVNGQMRNEAKVHVVRTDKTVAELRDLNLAQQNDSATHKDELFRIAREAVKDHFRLQPGQKQYVSVLLLDSHWDVGTQTITGHAALGSSTGDLKLAIFGSHSLQSYPSSLEDVVDAFSDCTRTDTGFVANDSGEGGSSWEAANIGIGAHLHEVGHLFGCPHQESGIMLRDYVRLSRSFLTREPFATRTKTQGLKLCLPQDECSWHRLDALRFRFHPCFRLPGDAPLASDDSIQVWPVENGKIVFTALTGIAFIELYAEGDNVCRNFIEYLNSESSSNGLPKQVTVTESELRQRVYGTEKEKKKSIRLVIFSGGLGSYNVDSINNLKSKQALVKLPKSHTGYKGNKMGFSQLEGSQPEQLLLDCAFASTKLLTSVRIYHENALHGLEFFYEDATSQLFGNRGGKPDDFVLDTRRGEILLGFYVRAGLWIDGIEILTSQGRKSGMFGNAQGGTGYTLIPPLGYKIAGISGSSGPWIDGFSLVIMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WJS7</accession>
    <name>A0A317WJS7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Purine and uridine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_575656</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467204.1">
        <property type="nucleotide sequence ID" value="XM_025615089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WJS7"/>
    <dbReference type="STRING" id="1450535.A0A317WJS7"/>
    <dbReference type="GeneID" id="37117232"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="336"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="942"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY86613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="961" mass="107845" checksum="A15CC32F776CBE1B" modified="2018-10-10" version="1">MPFTRNDYTVAWICALPLELAAAKAMLDKLHPPLPQPETDHNVYTLGRVNSYNVVVACLPGGVYGTISATAVVSHIISTFRNIRFGLMVGIGGGVPSQKADIRLGDVVISKPTATSTGVIQYDYGKTLRDGRFQHTGSLNKPPSVLLKAMSQMESDYMTGKRLVNEILTEVLHNREEMREQFSRPQDDWLFQPTYTHEESQHNCSACDPTKLVNRPERRTDAPYFHYGLIASGDQVMKDAKSRDAIAQDLDILCFEMEAAGLMDELRSLAIRGICDYCDSHKHKQWQGYAALAAASYAKALLSVVPIYWSQKASPEPREPVWMVPFRKNLGFVGREEEIARAEGLIMQQDGPGRVAICGLGGVGKTQVALELAYRMRTVDPECSIFWVSCTSYESVGQAYMSIAPKLGMTAIKPAEAKENVKAYLSQGNAGKWLLLSDNADDAEMWSKNNTNAPGHIIFTTCSRKIAVNLASPHVITISEPDTETAVKILQNSLVDRISPSDRDTATTLLEQLAFLPLAIIQAAAYINTNYIGLSDYLMLLQEQEPDVIDLLSEDFGDETRYKDAQNPVALTWFISFQQIQRSNQLAVNYLSFMACINPRGIPRSLLPQPMSNKEKFEAIGTLKAFSFVSEESGDRSLNLHRLVHLATRDWMRKNRHFSLQILKTADRLSEAFPSRDHINRKNQEKHIHLIENIWGCLYSDGRWKEAERMGMQMVELRKQALGPEHPSIITSMNNLASTYLEQGRWKEAEELEVQILQLSKQVSGPEHPTTLTSMSNLASTYRNQGRWNEAEELEKQEMALCKQVLGPEHPSTLISMSNLASTYWNQEHWDKAEEPGERVTKLYKRVLGPEHPPTLTSMSNLASIYQDQGRWNEAETLKIQVLDLRKQVLGPEHPDTLVSMNNLAVLWELQGKAEDALSLMENCVELCYKFLGPDHPDTISSADSLSDWRTARNSPPAQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WK99</accession>
    <name>A0A317WK99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="5">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF6</name>
        <name evidence="6" type="ORF">BO94DRAFT_518039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000016">
        <property type="protein sequence ID" value="PWY85702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WK99"/>
    <dbReference type="STRING" id="1450535.A0A317WK99"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by CK1" evidence="5">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY85702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="247" mass="26536" checksum="78B6E5567EDF2DFA" modified="2018-10-10" version="1">MAVRAQFENSNEVGVFARLTNSYAVVAIGASENFYSVFEAELQDVIPICHATIAGTRIVGRLTAGNRKGLLVPTTTTDQELQHLRNTLPDSVKIQRIEERLSALGNVICCNDHVALIHPDLERETEEIIADVLGVEVFRQTVADNVLTGSYMALSNQGGIVHPKTSIRDQDELSSLLQVPLVAGSVNRGSPVVGAGMVVNDWLAVTGLDTTATELSVMESVFRLGEMGPRGVGVGSANKESIVESFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLK8</accession>
    <name>A0A317WLK8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CaaX farnesyltransferase beta subunit Ram1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_556705</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467427.1">
        <property type="nucleotide sequence ID" value="XM_025613884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WLK8"/>
    <dbReference type="STRING" id="1450535.A0A317WLK8"/>
    <dbReference type="GeneID" id="37116027"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="114"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="340"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY87219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="488" mass="53051" checksum="B9F9D74A9F4FBBD0" modified="2018-10-10" version="1">MPIVIAAAGKPRRKVRFSSNQPPKAIAQSKTSRSSVSTSSRQPSAPTAKKDSMYEPQAHPGVPALYQELPRLLDALCTETSELQSETVEKCLPFLKGIHTSQAGPFNRYGVPSLKQDDHIGYLYDSLEEYPAGFAGMDASRPWMVYWALAGLCLVGEDVTRFRERVISTFSRMQNPTGGLGGGHGQLSHCASGYAAVLSLAMVGGEEAFNLIDRDAMWRWLGKLKQPDGGFRVCEGGEEDVRGAYCSMVIIAMLDLPLALPPDAEARQYGLETFASGLPEYLSRCQTFEGGISGSPGSEAHGAYAFCALACLCLLGQPDVTVFRSMDVPLLLSWLSARHHWVGSCWPLLQSALDGVQSAADPQGSAGNLYSREGLTRYVLGCCQSKHGGLRDKPGKHPDSYHTCYTLTGLSTAQHRHYHTTSSASSNEVFASAFSWKWTPITASEDTSSDQNVFDEKDRLKASHPIFVIPHAAAESMHGWCQRHPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WMV5</accession>
    <name>A0A317WMV5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_624591</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LCL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466988.1">
        <property type="nucleotide sequence ID" value="XM_025617230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WMV5"/>
    <dbReference type="STRING" id="1450535.A0A317WMV5"/>
    <dbReference type="GeneID" id="37119373"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016427479" description="Long chronological lifespan protein 2" evidence="6">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY86397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="133" mass="14005" checksum="81E5C475F3568E88" modified="2018-10-10" version="1">MFYPRLLGAFLLLLSASLAHAQFQFFEHMFGGAGGGGSGGGGGQRHGHGHQGGQNVPSDSSRYQGQWDSAICDKYLCPGTLACVHFPHHCPCPHPGVEEKVELGEGSAVCVSRGGFKEGEAARKIELARKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WN20</accession>
    <name>A0A317WN20_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Camp independent regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_58483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467699.1">
        <property type="nucleotide sequence ID" value="XM_025615657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WN20"/>
    <dbReference type="STRING" id="1450535.A0A317WN20"/>
    <dbReference type="GeneID" id="37117800"/>
    <dbReference type="OrthoDB" id="5572844at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="48908" checksum="699209240C211FCB" modified="2018-10-10" version="1">METYHGHVRTPADAIILFEACRIGLLPRVQRRLSEKERQLIRSGSVFVWDEREAGMRRWTDGKSWSASRVSGSFLTYREMEGKRGGTGVAQSTMSRAGKTPESTRGSDDDRADGADEGPDGYRYKPDGLMKQSFSITTSTGQHLHLISYYSRSHPSAANLQQPSTDPNLRHVRPQKGLYPESTVNDQQNLPVVTRGPMAGAAYVPPHPMAPYGRSPAAHPASYTPSYTWPPTPLATPPVPVHYPSYLPPVSQPNGQVPYGHGHGHGHQAAVPPGTPLPPPQPPGLPAPHERPVHAAEVTMAPSLQPSNVPVLASRSPRVHPGAHELLHRPSPPELGPPGEIIRTSPRTQPHVVSHSNGIASMARSPRLLSQPPSTSIHIPPPSAVVPKPLEASTGTTVPSIGALMNGAPSGSLPSITAPPVPAAGRAEGPRDIPSEKIGFGGEDMRALRQLDRVFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQF3</accession>
    <name>A0A317WQF3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BO94DRAFT_464515</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468025.1">
        <property type="nucleotide sequence ID" value="XM_025608069.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WQF3"/>
    <dbReference type="GeneID" id="37110212"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 15 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="12 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="243"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1520"/>
            <end position="1742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1574"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1602"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1686"/>
            <end position="1742"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="PWY88663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1742" mass="192717" checksum="9C1F9613F60C66AE" modified="2018-10-10" version="1">MANVYFPYSKAPLRTIKEIQFGLFSPEEIKRMSVVHVEYPETMDDQRQRPRTKGLNDPRLGTIDRQWNCETCEEGQKECPGHFGHIELATPVFHIGFLTKIKKLLETVCHNCGKIKANTSDPKFLEALRMRDPKRRFDHIWRLSKDVLICEADPPPDDDEPFSKESSKPLRMHGGCGNAQPQIRKEGITLVGTWKPNKMMDEMDMQQPEKKVITPQVALNVFRTISYDDVRIMGLSNDYARPEWMVLTVLPVPPPPVRPSVLVGGSTSGQRGEDDLTYKLAEIVRANQNVQRCEQEGAPEHVVREFESLLQYHVATYMDNDIAGQPKAMQKSNRPVKAIRSRLKGKEGRLRQNLMGKRVDFSARTVITGDPNLSLEEVGVPKSIARTLTYPEVVTPYNIEKLQQLVMNGPNEHPGARYIVRDNGERIDLRHAKRAGGQQLLYGWKVERHIMDGDVILFNRQPSLHKESMMGHRVRVMPYSTFRLNLSVTTPYNADFDGDEMNLHVPQSEESRAELSQLALVPMNIVSPQRNGPLMGIVQDTLCGIYKICRRDIFLTKDQVMNTMMWVPEWDGVIPPPAILKPRPRWTGKQMISMALPPGLNLLRVDKDSSPLSEKFSPLADGGLLIHGGQLMYGMFSKKTVGASGGGVIHTIFNEYGHETAVAFFNGAQRIVNYWLLHNGFSIGIGDTIPDELTIQRIENCVRNRKKEVESITASATDNTLEPLPGMNVRETFESKVSRALNNARDEAGSETEKSLKDLNNAIQMARSGSKGSTINISQMTAVVGQQSVEGKRIPFGFKYRTLPHFTKDDYSPESRGFVENSYLRGLTPTEFFFHAMAGREGLIDTAVKTAETGYIQRKLVKALEEVMVKYDGTVRNSLGDIIQFIYGEDGLDGAHIENQRVDIIKCSDDKFRDRFRVDLMDPERTLGPEVLEQANEIAGDVEVQRHLDDEWEDLLRDRAFLRSVCKEDEEMMQLPINVQRILETARTTFRIREGTISDLHPAEVIPQVRALLDRLLVVRGDDIISREAQDNATLLFKAQLRSRLAFRRLVTEYSMNKLAFQHVIGAIEMRFAKAGANPGEMVGVLAAQSIGEPATQMTLNTFHFAGVSSKNVTLGVPRLKEILNVATNIKTPSMTVYQEAARSHDKEGAKQLRSAVEHTSLRSVTEATEIYYDPDIQTTVIENDRDMVESYFIIPEDVTDDSSRQSKWLLRIILSRPKLLDKGLTVQDVAARIKAAYPKDIAVIFSDNNADEQVIRIRQIQDYKEDEEDEDVEYDVTLKKLEQHLLDTLTLRGVPGVERAFINEKSKVRVLEDGSLFASKTDPLCKEWVLETSGSSLGEVLAIPGVDATRTYSNQFIEVFEVFGIEAARTAVLRELTQVLAFDGSYVNHRHLALLVDVMTVRGYLTPVTRHGINRADNGALMRCSFEETVEILLEAAAFGELDDCRGVSENLILGQMAPAGTGEFDIYLDQNLMNTVVSNNARFGVMGALGAKDAIISDGAATQYDTGSPMQESAYIGSPDPESNFSPIRQAGAETPGGFTEYQPTGGFGGGFSPAATSPAGYSPSSPFSANPTSPGYSPTSSYSPTSPGMGITSPRFMTSPGFSPASPSFAPTSPAYSPTSPAYGQASPTSPSYSPTSPGFSPTSPNYSPTSPSFSPASPAFSPTSPSYSPTSPAVGGVGRHLSPTSPTSPKYTPTSPGWSPTSPQTYSPTSPNFAGSPTSPGGPTSPGYSPTSPAFSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQN4</accession>
    <name>A0A317WQN4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_545832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468111.1">
        <property type="nucleotide sequence ID" value="XM_025613261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQN4"/>
    <dbReference type="GeneID" id="37115404"/>
    <dbReference type="OrthoDB" id="3254104at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY88749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="28366" checksum="3DE7B717FA1BD865" modified="2018-10-10" version="1">MATAYTVASTASSTTYGWESNSTLSPQYNGFYSPSPEQQQERQTDQETVSAFWKFLAACSSYMVLAGFLVMPLAFGNEEKQSHVDKTSTIIAASVLIAIGYVTSLMLVCFQGHERAYLLHSLFLPCIASNLLALLNVLLNVLYRNLHPLGTLEIVSLSLPSAFAFLSTMGTLWSYVGDNYVVTRTGKHQSPLTEEEMQRQQLQRLLDHSSKGPSPRVIQKTFRVSAPEHINPGKGWDTFTPARRDEGYSNRWTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQX4</accession>
    <name>A0A317WQX4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative SNF7 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_535434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467526.1">
        <property type="nucleotide sequence ID" value="XM_025611781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQX4"/>
    <dbReference type="STRING" id="1450535.A0A317WQX4"/>
    <dbReference type="GeneID" id="37113924"/>
    <dbReference type="OrthoDB" id="3973241at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF12">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="173"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY87318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="215" mass="24049" checksum="604CA1DBB7BAB666" modified="2018-10-10" version="1">MNRLFGTKNTAPKPTLDGAISNVETRISSIDVKLASLNSELSTYQTKISKMRDGPGKNALRQKALKVLQRRKQYEAQRDQLSQQSWNMEQAGMMQDNLKNVMTTVDAMKTTTKTLKKQYGQIDIDKIERLQDEMADLMDVGNEIQESISRAYDVPEDVDEAELDAELEALSEETMMESSMGDSVPSFLQDEVAPPQFIDEPPEQTKVKEPAGGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSA5</accession>
    <name>A0A317WSA5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Found in mitochondrial proteome protein 29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_596146</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AIM9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467278.1">
        <property type="nucleotide sequence ID" value="XM_025616244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSA5"/>
    <dbReference type="STRING" id="1450535.A0A317WSA5"/>
    <dbReference type="GeneID" id="37118387"/>
    <dbReference type="OrthoDB" id="2831558at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY87070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="563" mass="63491" checksum="237A3D9629965E14" modified="2018-10-10" version="1">MVIDPHNYTSGRWLRGDSAERKARYIEFDFGALCRKVLEVSPEASTIVNYQKVEGGFNRVFIFELDNTKRVVARLPFKLAGPAQLTTGSEIATIKYLQANTTIPIPRILDWSYDAASTENTIGSEYIIMEHAPGIQLHKRWETMPGDQRVTCIDAIYRKMKEVVDLQFPAFGSLYFRNSRLCPDNNHALDEEFCIGSHCGTRYWNCEAGGNRSPGTMSLNRGPWHNLDEYSEGLVDAGLSQLPPVNSDIESKPSYYGSVETHNVLLRNTRSLLKRMSGDPRIKACATPLLFHPDLHKRNIFVSEDDPSIITGIIDWQAASIEPAFWYADDVPDFAMGNEICNKAFEVCTEFLTPTFSTPRLKDQNLFRPYRYSYRTWKDGAIALQHELIETSRHWEKLGFADQCPFPLPPATALATHQKEYRLFEAAQNLRCGLSDLLNTASDGWVPVQEWETTQAAHKELLDGMLQVVLNNEDADPDEPVKDEATLSLSKPLEARHHCHNFTADHKSLDTAYIPKNQPFGLCHGMPSYMADEVIGGNSLQHLMSDDRCDIVTGSDSSLYLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSE0</accession>
    <name>A0A317WSE0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_33401</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468285.1">
        <property type="nucleotide sequence ID" value="XM_025607001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSE0"/>
    <dbReference type="STRING" id="1450535.A0A317WSE0"/>
    <dbReference type="GeneID" id="37109144"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY89374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="401" mass="42798" checksum="2F013E32BD023342" modified="2018-10-10" version="1">MEGLFTLLALSVVMAITSFVVGSLPLAFSLSPSQLRLISSLGMGVLVGTSLIVIIPEGVETLYSANSLSRRKELSSRSTTAINWQHREIPVTDILGSREAPEYSDADEASHSILSTLSSTPVTIPTVYSTPDEQPRLQGRKEEASDDQADESHDEDNSPHAWIGIALISGFILMYLIDKLPVFASPAKQERTPYHISLDNLGSGLRRNSSPSREGGLLDAGNIPRRSHSLATTTGLVIHAAADGIALGASSSDTGLSFIIFLAIMVHKAPASFGLTSVLLKQGLSSRTARAHLLIFSLAAPVGALMTFLFVQIMGSGSGSDDIGNRWRTGVLLLFSAGTFLYVAMHTMQENSPNSSSRESQANGYGDHRETPSASDKSMRDLIASVIGMVLPLFLQIGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSR9</accession>
    <name>A0A317WSR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF155-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_534139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468290.1">
        <property type="nucleotide sequence ID" value="XM_025611473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSR9"/>
    <dbReference type="STRING" id="1450535.A0A317WSR9"/>
    <dbReference type="GeneID" id="37113616"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="306"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY89379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="531" mass="59296" checksum="433B231D88CCF702" modified="2018-10-10" version="1">MVSTTESSPLLPQHNPTASNTSPRGNRPPRTVTFNPLATVSTYHDTTSADPTFRPLQSASSSAPHSQESQYRPTGLSALNSKLRRRNSHGSPFSTAHPPIAAAPKVGPQRTTKKAQKLKLLPDPVTAEEEELAGDDFPSDVYSQIARIKEPTARSHAARLGKADRERLPRVTAYCTANSYRLEGIIKFLKSRSKTRGANPKLYDECVYSPYDYDYEEKQKGTWGISSNGLSLGDSRPPERPSNERRYSDSVVEVQDNTNARREDLIDLRDPQSHATDIESASTTAVAENQGEVHPDLDTTIHTPEVFLFDYGTVVIWGMSPAHESRFLSDISKFAASILSPEDTQVENFNFYYAREYQARIYNDFISLRDPRNHMIKLAISHALAQSVKTSLFEDLVSETISNTAPLPAQIAKTGSVNLTRRQINMQIGELFILRINIHLQGSVLDSPELMWAEPQLEPVYQAVRSYLEMDQRVSLLTERLDVIADLLAVLKDQLTHRHGEYLEWIVIVLIAAEILVAAINILVDLYAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WSY2</accession>
    <name>A0A317WSY2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_37342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468377.1">
        <property type="nucleotide sequence ID" value="XM_025607226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WSY2"/>
    <dbReference type="GeneID" id="37109369"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016408262" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="22"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="26218" checksum="3AF3ABF86B5F3972" modified="2018-10-10" version="1">MYLNHFHFPFPLPLLLPLVLATANNILTTTSVFTTTISTLQDLDLTSCCLNHTILNLEYNQTALPSPSPNLTLQHVALGRGVQNYTCPSSPANDTAKPTSTGALATLFDASCIVSSDQRLLHRIPAFLQNVPLETLDFFASLASLAGPDSAILGEHYFSASAMPFFDLRLGGNDEWAAAKKVASVVSPVASMDVPWLKLVAVDGVGIKEVYRVYTAGGMSPATCEGMKSEFSVDYAAEYWFYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTB6</accession>
    <name>A0A317WTB6_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_515189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468555.1">
        <property type="nucleotide sequence ID" value="XM_025609908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTB6"/>
    <dbReference type="STRING" id="1450535.A0A317WTB6"/>
    <dbReference type="GeneID" id="37112051"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="560"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY89644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1053" mass="116625" checksum="99DE1A20E6457AB5" modified="2018-10-10" version="1">MGIPQYYDGVPDEAPKPTALSTADVVARFGRLHLLDDLIRLRAADAVQHPILAYPKPTEDDSVSYEYFTGHDLDCMVDHAVYTLMDYGFKPPREDGATVALFTLSDLNMVVTFFALSRLGYTVMMLSPRLSATACVSLLDTVGCDTILYGQSPNIRATLGDILRLKLIACRPIIQRASVEASQDADVFMIRRNRRPELLVNRTALILHSSGSTGTPKPLYLSHKALMTHPMRGPGFTSFNSLPWYHLHGLSTALQAMYMRRTAFMWDASLPLTASTAVAVLEAARPESVQGVPYLLQLLIDNPRGLKALRACKFVTYGGAPCPDELGDKLVEEGVRFGGSFGLTEAGLVAESISRPAGDPFWNYMRFFDNIKPFIWMKPISDALYEVVYLQGHPALTASNSNDPPGSFHSRDVFTPHPTIADRWKYVSRLDDRVTLVNGEKVLPLPIEGCIKQNPLIQEAVVVGVEKAVPGLLVFRTENSQMFSDEEFLDLIWPTVEDANSRAEQFSQIARDMIVVLSADSVCPRTDKGSMIRAQVYTKYADVIEDMYTNEQTVDGTLQLDLPATEKHLIKLCHEELGFPISSPSSDFFAEGLDSLKAIHLRRLILKDFKVQDPKSISHNIVFETGNITRLAGHILAIQSGHEEETEDEVSMMPGLIEKYSVFQSHTPSPSLVTSNKSVVLTGATGSIGAHTLYKLLNDDTVSVVYCLTRRSQPEEAITNTLTQKSLSVLPHRLQKIVALTSSLEKPDLGLGPSMLAQMRQSVSLIIHSAWPVNFNLPLTSFEPHIKGLHNLINFSLSVNLPDPAVLLFCSSISTALDSSSPVDETPITDLTSALEMGYGRSKLIGEKLISNARKSGARTYSLRIGQVSGHSKKGLWNDSEAIPLMIRSALTLHALPALDMTCSWLPVDKLACSILELAKACSINSLDSHWDDTTPTDDDSIYNLCNSRVFTWSSLLSTLKQSGFAFKTVPFHTWLQLLRESEARGEEEINPAVKLTSHYEAMYSGDAPEQVKFLTEKAERDSMTLRNGRLRIIQDGILARYAQDWLRRWKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTV2</accession>
    <name>A0A317WTV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_545790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468064.1">
        <property type="nucleotide sequence ID" value="XM_025613258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTV2"/>
    <dbReference type="STRING" id="1450535.A0A317WTV2"/>
    <dbReference type="GeneID" id="37115401"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000019">
        <property type="entry name" value="Protein translocation complex componenet (Npl1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000169">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="105"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="635"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="653"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="691"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY88702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="717" mass="79905" checksum="1AF4B85BCC72FA47" modified="2018-10-10" version="1">MSTDYNYDDKGQFFPFFVLTLTSLVTLPLTYNLLRPSKGLENTAPRIKSEFKPEHAELIEAQKRKRLRKERRIKRIVTVIVGYAVMAWMVYLIIVTARITPKVWDPYDILGVSRSADERAISKHYKRLSLVYHPDKIRPDPAKNETLEMLNDRFVELTKAYKALTDEEVRNNYIQYGHPDGKQSMSIGIALPTFVVSEGNSKYTLLVYGALLGVLLPYIVGKWWYGSQRYTKERVLVASAGDIFREYREDITDGGIVNALSTGAEFKEMLQGPKTDAGLAKLEKKVLAEDSSFLSPEDRNVIKSLDDSSRRKALALLWAYLGRIDLDDTTLNGEKYEAAPIALSLNEAFTAIALAFGNVRPILGSFRTSQHLIQAVAPGSSPLLQLPHFTEEVVKSVQGADAKEHYTVQKFMSIPEEKRRSLTVGAGLLSEKQYTAATTVAKQLPVIEVSRAFFKVMGEKVITPSSLVQLVVKARFVPPGFSNVPQVDPVELEDIDPDEDDLDAIMGRKPAKNRTTKLVNGVKVEEKVEAIQPPLAHAPYLARDHSPRWHIFLADAKQGKMAVPPFTFTTFDKPLFDADGKPTFNVQTLKMQFQAPPQVGDFTFVLNLLCDSYLGLDTKMEVTLHIDDPAKAAALDEEDDISEPDEGKLTHFNPASHSMLTKSPTDSIAGQMQALKTGQPPKKKTRKPSEESTDDESDTDGDAGDTSDTNTETDIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUD5</accession>
    <name>A0A317WUD5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_623865</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468159.1">
        <property type="nucleotide sequence ID" value="XM_025617179.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUD5"/>
    <dbReference type="STRING" id="1450535.A0A317WUD5"/>
    <dbReference type="GeneID" id="37119322"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="5"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY88797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="364" mass="38775" checksum="B9D9EC3C03279972" modified="2018-10-10" version="1">MPAFNVVVFAGDHCGPEVTAEAIKVLRVIEKKRDDITINLQDHLLGGASIDATGSPLTDEALTAAKNADAVLLGAIGGPKWGTGAVRPEQGLLKLRKEMGTFGNLRPCNFAAPSLVEHSPLKASVCEGVDFNIIRELTGGIYFGDRKEDDGSGYAMDTEPYSRAEIERITRLAAHLALQHNPPLPVWSLDKANVLATSRLWRKTVTEIMAKEFPQLKIEHQLIDSAAMIMVKEPRKLNGIIVTSNLFGDIISDEASVIPGSLGLLPSASLSGIPDGKSRVNGIYEPIHGSAPDIAGRGIVNPVAAILSVAMMMQYSFGHFDDARAIEAAVRNVIESGVRTGDIGGKATTKEVGDAVAAELEKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUU8</accession>
    <name>A0A317WUU8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_46070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467980.1">
        <property type="nucleotide sequence ID" value="XM_025607892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUU8"/>
    <dbReference type="GeneID" id="37110035"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="156" mass="18099" checksum="343F8BA878B8BF08" modified="2018-10-10" version="1">MGRGRVEMWERERGRERRREKNGGMGEERSRGQDGEEKEEEEEEMGGRQEGKLGGRTRHRQTERHRVDERRGADKRNCQLLVKTSSPEDLKTESRKIECRDGTVEGVANERAKWLLVTLRMAERARGWMDGDSRQLAAPLLIGSWMADAEWTELSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW37</accession>
    <name>A0A317WW37_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GYF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_534302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468443.1">
        <property type="nucleotide sequence ID" value="XM_025611513.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WW37"/>
    <dbReference type="GeneID" id="37113656"/>
    <dbReference type="OrthoDB" id="48509at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00072">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051640">
        <property type="entry name" value="GRB10-interact_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445:SF36">
        <property type="entry name" value="FI03272P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14445">
        <property type="entry name" value="GRB10 INTERACTING GYF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00444">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="733"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1234"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1158"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1204"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1298"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1325"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1361"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY89532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1522" mass="161279" checksum="CD379273DA7268BB" modified="2018-10-10" version="1">MPTPLPSSFASAAAGNAHDSSTRRGDGPAGGEWSRTRMNGATQTFRRPSVATNPSHNRDVSQPTSATTPTVGTYTPPHMSSNYPSSAPRNGAANDTRYSKDQLLSLYKTQRESGILGKNVADYFVADWNPHETSPDNPSGPEVCWDHGGQSEPLGLVDLTDDEKELFTLSVNSPLKPPPTNASKENVAPGTGGRKLSISQGHMNNYNTASPSAARPGPRRRETGDSTGNPMSPTTSGSRFFRDETNTSTPPPSLLRRKTDFRDASSAARWEEKEKENVGRDVGAEVSSPFGSLKRSSTNPLNVAPGASNSPWGSASQNASFSPMGAFGAFSLGTATTPTTEKKAGFGSLRGESRLKGLFSKDSSEDISAAIKEKPSLSSLERLGEAEGEKRAQSPWGEPVKTRTGRSETNPFSEEPRSGSAALGGSQEINTPAQTADQLGFGAFGMTSSIPGFRELMQSHENSRNPTPSLLQGHEPTSPTNTNPYQSPHGDRSGAAAGGDDDVDTDGSDIQNTTHPGISGLRDSSSAFGSIRRVGSGMDLPSIDRSQTSSAAGNRSFSSLGGLGGLSSLGGAAGWPSSAAVGTPTRERSAFAGGFGDPIFGTMGDLQSPSLSTLGGSGLFSPHAGISGTGSLGRSSKLGSLFPAAMQEQMQGDQGRPDLGALDDGSRQPDMQGEKPGQMSQPPTTSASPDPMAAVGSMSTSIAPEAPPPSQTPGQVGAGVPPAQQRTMVMPDRMRWIYRDPQGNIQGPWTGLEMHDWFKAGFFSPDLQIKKLEDPEFEPLAQLVRRIGNSREPFLVPQIGIPHGPDPSPGPWTGNTSGTAQPPFPGSFPSFGTTLTAEQQNALERRKQEEQYLMARQKEHLAQQQALMKQMQFQGVPHTMHPHQLQHHSSAHSLHSQPSFGSIASPIGFQPSPIQAPMQQPQSVAGFFDAAAPVRNPLQSVGPQVLGTDLVNSQDQLPALLDRLNVSRPDPFAFGTPSSFAARQPDSLFHQQQVASMLQDRARLQQEQEQFDSAQGDSLFDQQAREERLRQFHALRAQEGELGLRTAEGLPTHPATALQPEESEDVEDLVEEEEEEEVVVVEEEPTLTLSQQVQKAASAQRKQQEQQEQQEQLQREQQEQQSLDTTDAPWSVKGDSAMPQPFPPPPSASPLPAPAAQRNRQNVAESLAANSRSQTQTPVEAPTTSIAPWAKEANEVPKGPSLKEIQEAEARSAAQKEELAAAARRAQLLAEQERLSQVQAQAPGLPSTANWASAGSPATPTSSGSVWNNKGQAAPSGTAKKTLAQIQKEEEARKQRLAAAAAAQNAAASPPAAPSSTGKRYADLASKAPAASPVSASANVSGAWTTVGAGGKPKPPPVVPSGPRSTSSATPVAVSPVKPKPATIATPRAVVVATPPANPNRAVEEFTKWAKLALGKGLNSNINVDDFVQQLLFLPAEAEIISDSVYANSQTLDGRRFAEEFIRRRKLADKGIVDPVSASAFAEKSTGGWSEVAKKGSSNTHREEDNSNTAFKVVAPRKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWL4</accession>
    <name>A0A317WWL4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyanovirin-N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_584445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468813.1">
        <property type="nucleotide sequence ID" value="XM_025615627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWL4"/>
    <dbReference type="GeneID" id="37117770"/>
    <dbReference type="OrthoDB" id="2441380at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076:SF1">
        <property type="entry name" value="CYANOVIRIN-N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42076">
        <property type="entry name" value="CYANOVIRIN-N HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="110" mass="12495" checksum="3FCFDA0C262DF4B0" modified="2018-10-10" version="1">MSFHNSCQNIHLIHENGSTLLHVEARRRNGEVVARTIRLDRHIGNTDGWFIWGGSNFTESSHDIQLEHTERGPKLTAHLRKNDGGYRELQGIYLADKIANEDGHLVFLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WWR3</accession>
    <name>A0A317WWR3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_515153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468538.1">
        <property type="nucleotide sequence ID" value="XM_025609907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WWR3"/>
    <dbReference type="STRING" id="1450535.A0A317WWR3"/>
    <dbReference type="GeneID" id="37112050"/>
    <dbReference type="OrthoDB" id="3852249at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY89627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="374" mass="41146" checksum="204BD864645A722C" modified="2018-10-10" version="1">MMESILEMFGSGPIPTLLTILITVIPSASSIWTDRTARQAAAAKKKAAEASRIASEKTAQAQDAIYEEAIRNMAGNEYREICIPSNGFNAGPAFTISLAACILVGIKLTERVGKDLQIIGLRLSEIRNELGQQTTAMIQGWQTHGFGAFIYWFLDNEIRDAGGEASVGCHAFYVYNPTTSANVVFKNLLRENPLPASFAGICSDIEAVFLLMWQNRQTLFQTDPQKAKNMQFHLLVPAKRSFAIFERMVIDKGVGKLIIKGHTDEGTCYAWFNFVRVPRHVVLQDVGNLDTDHADRERSDRRFIWSWSTGVGFWFAGFISTFVFPPAGPYCAAGFMGSWASAAKYGPVDDVLQSFRSAPRVLGPPANVTNPSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZE7</accession>
    <name>A0A317WZE7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cullin binding protein CanA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_378989</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469484.1">
        <property type="nucleotide sequence ID" value="XM_025607245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZE7"/>
    <dbReference type="STRING" id="1450535.A0A317WZE7"/>
    <dbReference type="GeneID" id="37109388"/>
    <dbReference type="OrthoDB" id="438080at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="200" mass="21589" checksum="F9F594CE07BACB84" modified="2018-10-10" version="1">MPLSDHAPRLEFLRSSASSLNALGPSTAAYLMTLHNGIIYDEFKPLNQRHREASCGACGSIRSEEWTKTINIPKRKGKPSKPGSAARPASEGATILKCLRCRRRTVKPARKEASRPTMPAKSIPTTASTPEIQSSAATAPRSGPTCELADQNKVNKAADNANSKKRAKARKQGGLQALMASKQQSLTNSSSLDLFDFLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X2W3</accession>
    <name>A0A317X2W3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_357784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469735.1">
        <property type="nucleotide sequence ID" value="XM_025607147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X2W3"/>
    <dbReference type="STRING" id="1450535.A0A317X2W3"/>
    <dbReference type="GeneID" id="37109290"/>
    <dbReference type="OrthoDB" id="3477330at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY92974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="706" mass="79588" checksum="929239424EE6E367" modified="2018-10-10" version="1">MTSVSVLTTTTAPRTVKPVDAPARSRSLGGCETCRRRHAKCDETRPSCLVCERAGLVCERYEIRLLFDASDSQGSRCRRPLFTEDMRQRMSEQLAASLDPDDVHTILTRMEDHCEKQEEETSTNFTTHLGPFGAFRIVQPEIDLAEIPTDPVDEPPQVQDSSPNIGLDMALDDAFSNDPLMECLFGHVNVDASGDFEAQDFFATTLPFPERDEISPQSLTGGFLMGSSSVPLQASLLSSPEIRYAPSVTNLAPPDAPLLLAAYKNNVTQLFSPIQLEKSPWGMLYVPPAMETLALLAMGELANNTRMSIFYAILATSAFNQRLSTATRSSNEYWQRQAETFAVEAQSYLKRALHDASSSVKKTKYKDVLIALLCMNTVSAYQGSPERVRRCLLDCENWIQFRGLPKTRKSRKVRLLHHCYVYLRIFQESTSVLPVPHVEAEIDPASPETVRSVASTRSFRLRQWEGRLDQRMSELKEQHQGENDLHLEIPGRWDSTMYPQIFGMPESLLFLLSQVTRLGNERDLSDSGTYTGALDFKQFAARARSLERCISTWRPPPISDEDADSIVGQANATLIRLMLSALHKALLIFFYRRVYDVDPMILQDKAWQVRDALAQVDRDDVPGTRVAAPFAWAAFIAACEALEPTLQDWFATWFETSARRSGLGTFKLALRTARQVWERQRHPLNSSASTSWPQIMRESNLSLFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X331</accession>
    <name>A0A317X331_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_532800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY92966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469727.1">
        <property type="nucleotide sequence ID" value="XM_025611196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X331"/>
    <dbReference type="STRING" id="1450535.A0A317X331"/>
    <dbReference type="GeneID" id="37113339"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000022">
        <property type="entry name" value="NADP-dependent alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="14"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY92966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="331" mass="35712" checksum="39A77ABA904F62C3" modified="2018-10-10" version="1">MGYDFTVFKGSKDGSITEGTTHRDDLQRDEVLVRLTHSGVCFTDVHYQHADMALGHEGAGIIDEVGPEVQDLQKGDRVGWGYQTGCCGRCAECLTGWETMCPERKMYGSANLDQGSFATHAVWREPFLFKIPDGISNEDSAPLMCGGSTVFNALHVSGVTPTSRVGIVGIGGLGHLAIQFAAKMGCDVVVFSGSDNKKEEAMKLGAREFYATKGAKELKIGKPLDNLIVSTSSQPDWKLYVDVLAPGAVISPLSVDNEDFKFPYMALLGKGLRVQGSVVAARQVHRDMLDFAALHGIKPVAMKYPLSVDGVSDAMKTLEAGKMRYRGVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X3A4</accession>
    <name>A0A317X3A4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Succinyl-CoA synthetase beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_583284</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469804.1">
        <property type="nucleotide sequence ID" value="XM_025615548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X3A4"/>
    <dbReference type="STRING" id="1450535.A0A317X3A4"/>
    <dbReference type="GeneID" id="37117691"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp fold succinyl-CoA synthetase-type" evidence="11">
        <location>
            <begin position="66"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="10">
        <location>
            <begin position="263"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY93043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="42735" checksum="11CCA1896D7FAD2A" modified="2018-10-10" version="1">MSFVQTFGPRASQQILSLLRFSRPTQRRWLSIQGYQAQNILQQAGIPVATGEIARSTGVAGDCRRSAESPGEARTIASRKLSHRPNARQNKASELPVDKPQTTEGTTLKTEFYLAITVDREHYCPVIIVSRKDDVRIGELGRHNARRVHIDYSKGITDDTVRSIIKTLALEQGLTKNLHSLLEGLYDTFISKDATLLEINHVVKTDQNTFVCSDPNFTIDDASAPRQPDIFSIKADEQEHPTETEAKKHGLVYVHLDGNIGTIVNGAGLAMATNDVISYYGGKSANFLDAGGQATTETMVKAFQIVLADHWVKVIFVNIYGGIIRCDMVATSIIQAADRLGLLRCPIVVRLQGTNSEEGQRMISESGLNLIAESDFGRAAKVAVETANSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X4M5</accession>
    <name>A0A317X4M5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_532510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470335.1">
        <property type="nucleotide sequence ID" value="XM_025611131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X4M5"/>
    <dbReference type="STRING" id="1450535.A0A317X4M5"/>
    <dbReference type="GeneID" id="37113274"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000222">
        <property type="entry name" value="Raffinose synthase Sip1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY93574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="930" mass="103408" checksum="EC9F6EECA96F3727" modified="2018-10-10" version="1">MQADPRHRSTLPICGPDRNNIKKSQIKFIRPAQMSLLARVTCYPPLGQVTCCPRVGKPSGSQEPDTITFTVVLESSTSFPVQPWDVQVWHNIASSEWTASSLAHSKPSVAPLMTGSAETYKCFRHVFSGEITLPADPGYAQFTVRYRINPDAEWQWVNQHQSVSDGVLVFGSHNPGFNSLESTSAEFKKYFDSMSSNIEIQPRKSEAPGSNLWHLSGEADPAREGESGCKELTLGVPVSVLRYFSLVRIWTPWLGPRHGQGKFALTEDAIMCSFLRTDGVHVVLLGLSGTDNVLTFFGSGQNGEVVVKSLSDNTKPSKFQILASASEDFEVAMSAIIYEARKLARPYAEQEKPEPIRAPVSPPPDDIVVVEKDVKAQWLAEWYDGLTYCTWNGLGQNLTEDKILRGLDSLKSHGIKIANLIIDDNWQTLDEADSQFKRGWRQFEGNPNAFPKGFKQTIEAIRRSHPNIEHIAVWHAMLGYWGGISSGGDLAKKYKTKRVELKVPAVGGTISHAFENGSILAIDPDDVQRFYDDFYRYLASIGVDSVKADAQFFLDLIKDPEDRRRFITAYQDAWSISTLRHFSARAISCMSMFPQAIFHSQLPTNKPTIPLRNSDDFFPDIEASHPWHIFCNAHNALLTRYLNVVPDWDMFQTSHPYAGFHAAARCVSGGPVYITDEPGKHDVSLIDQMTASTVHGGTVILRPSLIGRSMDMYHDYNEGHIVRVGTYTGWARTGSGILGLFNISTTEKSTMVHLLDFPGIHHDSQGEYIIRAHTSGMITENLQVSDTGSLVSVALPQKGWEILTTYPTHTFNMKTTSPTKVAVLGLIGKMTGAAALIYSDIYLENNGRIRFDISLKALGTVGIYFSDLWNWSIEENFMVTILGKPVPRKTVWKEGGDDSNVLAVDIQAAWNEMSLKAGWSNDVLVEIFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5F3</accession>
    <name>A0A317X5F3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_533237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469508.1">
        <property type="nucleotide sequence ID" value="XM_025611294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5F3"/>
    <dbReference type="STRING" id="1450535.A0A317X5F3"/>
    <dbReference type="GeneID" id="37113437"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY91780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="320" mass="36652" checksum="1B77256EB04AAA99" modified="2018-10-10" version="1">MSKRRLFRWPARRTAGLGCLALLVTSVVSWYLYGGQPEEPQPVPQIQPDTDHEIVTSQLAEITATYSNATNEIGLVLAATVREDLTWLLNYCKDHGTIPFIYTTDEPPAPHLLVPRTIRGREAAAYLSFVVDFYSQLPKYTIFIHSNLDQWHNDLFGTHTSPALKNLRLEAVDAQGYVNLRCEHNPGCPTSVHPWNPTQIDIEKDDIRAYFPQVYQTLLNVPLDQVPEHIGNVCCGQFAVSRERILQRPREDYERMLRWAEETDLTDSFGVGWVYEKIWHIIFGMDMIYCPRYEQCRCDTYGWCGPLASGETLQAVRAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X5K9</accession>
    <name>A0A317X5K9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_555005</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469558.1">
        <property type="nucleotide sequence ID" value="XM_025613761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X5K9"/>
    <dbReference type="STRING" id="1450535.A0A317X5K9"/>
    <dbReference type="GeneID" id="37115904"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000059">
        <property type="entry name" value="Inositol phosphosphingolipids phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="422"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="29"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY91830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="471" mass="52690" checksum="86F66E6E416E4693" modified="2018-10-10" version="1">MTTSESLASPPPSSNPSSISTPTHIRIFTLNCWGLKYIAKHRNARLAEIGRRLAIADPAPEIVGLQECWTQQDYDSIRQQTRHILPYGKFYYGGIWGAGLAILSKWPIEESSMYGYPLNGRPTAFFRGDWYVGKGVACARIRFGPGVQDVAEVFCTHLHAPYEREPNDSYICHRTAQAWEIAKLMRGAAERGHLVIGLGDFNMLPSSFAHQLVQAHSPVRDVWQVLHPDSSVGAAIDPVEQKRGKPVPSAEFNILENGATCDGKFNTWRWEKEDQKRLEKGEEVVVDKDAPCPKGKRLDYIFVGDGGYAPLYPAPRWSVESTRLSMTERHPTLRCSLSDHFAVEAVITRVGVQVEGDTKEKSVAPNTSLTSDTYDMILEMIHKYVQREQSQLRWRLAHFVASVIVSIGCFIGVWWTGDHLPYVAFILVLVSTLNFGAGILDGLIGGLFMSSELRALKEFEWEVQNAKQIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6E0</accession>
    <name>A0A317X6E0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_615992</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469888.1">
        <property type="nucleotide sequence ID" value="XM_025616789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6E0"/>
    <dbReference type="STRING" id="1450535.A0A317X6E0"/>
    <dbReference type="GeneID" id="37118932"/>
    <dbReference type="OrthoDB" id="2873061at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587:SF6">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35587">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="131" mass="14463" checksum="FCA79E35B1D51583" modified="2018-10-10" version="1">MAQSSTHHQPQSAPVVTQAQQQHQPQPFPSARRPSRRNKQYPLGGYAPPDTSTALQPVRRGLSPLPSDEEEEVLDRGGRTRGKLASQPAAQDMDQMPEQEETGLKLKLELNLDVEVELKAKIHGDITLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X6K1</accession>
    <name>A0A317X6K1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_543488</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471015.1">
        <property type="nucleotide sequence ID" value="XM_025613140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X6K1"/>
    <dbReference type="STRING" id="1450535.A0A317X6K1"/>
    <dbReference type="GeneID" id="37115283"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22881">
        <property type="entry name" value="Mdv1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000404">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000881">
        <property type="entry name" value="Mitochondrial division protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="357"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="432"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="514"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="537"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="238"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY94254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="655" mass="72083" checksum="564D905A834EEDFF" modified="2018-10-10" version="1">MDRHRRRDESPSGLSDIVEPDGLLGTGITSRHLEAFGRKVTSTAGHLMGPAPDSSSGGHYHSAMVDIQRELRHPTTQRKVFSLTQTTPTDLVRSKLSTTEIQSRAISSLPDDLLANIPDDSSSYSLFQGFQASQDDIEYRRAHRRRSSKSKKLLKDGETGGALPSAPSDLKKERDLLSRRMELMGVRKNMCSSEIHDIDNKIANLHNMRKIVLDRLAGLEMEEAELEHELTQVENKLEDLQEEEPEVAPPATPKSSEANDDSVASEDPAMGTSFMSESIYQKIPSPKSVKQRSIRKRSMPVLHEHFAPGSEIKEMHAHSDIVTAIDFDYPFGTMISAALDDTVRVWDLNVGRCMGFLEGHNASVRCLQIEDNIVATGSMDASVKLWDLSRARTTARDNRITRRDDDDDSAHADDASMASHSTTLEDCFTYSLDAHVDEVTALHFKGDTLISGSADKTLRQWDLVKGRCVQTLDVLWAAAQASTLGGDTAWRPSGRLPDASADFVGAIQCFDAALACGTADGMVRLWDLRSGQVHRSLVGHTGPITCLQFDDVHLVTGSQDRSIRIWDLRTGSIFDAYAYDKPITSMMFDTKRIVAAAGESVVKVYDKADGNHWDCGAGVGVDETGPMPATVERVRLKDGFLVEGRKDGIVAAWTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X708</accession>
    <name>A0A317X708_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_572873</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000006">
        <property type="protein sequence ID" value="PWY93422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025470183.1">
        <property type="nucleotide sequence ID" value="XM_025614945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X708"/>
    <dbReference type="STRING" id="1450535.A0A317X708"/>
    <dbReference type="GeneID" id="37117088"/>
    <dbReference type="OrthoDB" id="2257100at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000175">
        <property type="entry name" value="Basic-leucine zipper transcription factor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF38">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="230"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="196"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY93422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="294" mass="32632" checksum="C531F715024D3028" modified="2018-10-10" version="1">MASIKGTGLKLRRSTRLTKPQTRFSLPSPRSGSSGSKDPATSIQGWLSLQSPCTTPARPPRSSTRSEKPPTFDYQHHYQHLQQPPHYSDPFYLPPEFHPIPQLAFSDFDLSSSAAFPPVDTSLFYESPDTSLPGSALSSLSDSSYQDQIIGFDPSCAPLPPLIPVTAADPDPIDALLSSPDSLNLFQSPSVQSAPANWTEFSEPSPPQMPAVSNTASPLNLSRADTPKETPNRVKKRELNTMAARRYRQRRLDRMNQLEEELEAIKRERDELKMRVSKLEGETEALRSMVKGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7E2</accession>
    <name>A0A317X7E2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1214-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_531432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471220.1">
        <property type="nucleotide sequence ID" value="XM_025610897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7E2"/>
    <dbReference type="GeneID" id="37113040"/>
    <dbReference type="OrthoDB" id="2018906at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.600">
        <property type="entry name" value="Domain of unknown function DUF1214, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1610">
        <property type="entry name" value="Domain of unknown function DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010621">
        <property type="entry name" value="DUF1214"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037049">
        <property type="entry name" value="DUF1214_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010679">
        <property type="entry name" value="DUF1254"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037050">
        <property type="entry name" value="DUF1254_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36509">
        <property type="entry name" value="BLL3101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36509:SF2">
        <property type="entry name" value="BLL3101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06742">
        <property type="entry name" value="DUF1214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06863">
        <property type="entry name" value="DUF1254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160935">
        <property type="entry name" value="VPA0735-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1254" evidence="2">
        <location>
            <begin position="69"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1214" evidence="1">
        <location>
            <begin position="338"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY94459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="463" mass="51739" checksum="2A5C7305B3CD3EA7" modified="2018-10-10" version="1">MAQYHAESVAVTPPATGIIMTPSYARTIAQMAYIWGWPMVNMLNREASVTQAPRPGLLDGILPVAPRGQVGMLHDYIEPAETFVTCPNQDVVYGLGFFSLDEQPVIAQVPDFGDRFWVYALYDARTDQFGQLGKPYNTKPGFYLLVGPRWNGLKPDGVREVIRCSTPLANAIPRIFQNDTPEDKEAIQKVINSVVFYPLEDFTGKMKTIEWANLEDIPGPGGDGGDGETKWVIPEQFFDQLPDVLNTVEPLQGEEALYGQFRLLLDAAAKDPELKKVVVATAVEAEDRVIPPFFEWKHNGRPAGNSWNRSTNNAQFGVDYFNRTGTSKSNMFDNRPTETQYFYTDFDSVGGELEGSSSYEIIFAAGEEPPVDGFWSLTLYNDKHLFHANDLKRYSLGTKSKTLQRNADGSLTLYTGAKSPGGEKESNWLPAPDGRFSLYIRAYWGQEGILDDSWTPPIIRKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X7Y8</accession>
    <name>A0A317X7Y8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_615719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000007">
        <property type="protein sequence ID" value="PWY93018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469779.1">
        <property type="nucleotide sequence ID" value="XM_025616767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X7Y8"/>
    <dbReference type="STRING" id="1450535.A0A317X7Y8"/>
    <dbReference type="GeneID" id="37118910"/>
    <dbReference type="OrthoDB" id="5207033at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY93018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="405" mass="46462" checksum="5B6FA5D9703A0CE0" modified="2018-10-10" version="1">MDELRELALQAFQQRTFSPVKGIVGYHFLQLSADGHDYILYESLISEDDLPNILKHANNIHPSITFFQIRTDRAQSIQITRAGFLHLATLMGLDPQVLYLIAHDYDGYHHLGEADNTATDFLGTSRFSLIWNRRPQSQSTVALVLVRRDSPFPELLHLANTYRNHLANPHILPFLAIVYIVRVFDRSVAQDLEKIHYVEARTGYGPNNPVSPSTRFNIHDISNWLKEIGALQAYFANKHRQLDIVRQIIPSIAQGNIQNHQDPLCMALPTIEDIARTLNGYITYLEERSKTLVSILFALLTHEDAAASADLAEASKRDSSAMKAITILTMAFLPATFFATLFALPTLQWNQDRIIQRRFWVYWAFTIPATAMVFGLWGGMLKTRRVWRWLGQRWAQHQTRDEKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X802</accession>
    <name>A0A317X802_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_572219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000004">
        <property type="protein sequence ID" value="PWY94659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471420.1">
        <property type="nucleotide sequence ID" value="XM_025614910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X802"/>
    <dbReference type="GeneID" id="37117053"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY94659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26387" checksum="6A2E69E324951548" modified="2018-10-10" version="1">MVPEAQTLYANPQTYRNFGPRTGNIQQEPVVDEEYMFEDIIANPWATAITECMLGPNPHLRFYSANTAFKAEDRQPVHVDVHFDFPKIPFGFCININLVATSPENGATELWPGSHRDADHRDSDSTGVISDLVEARRKISPPVQPSLPKGAVIIRDFRLWHAGMPNRTDDPRVMLVTIHFPAWYRTDQKFVLPKGMQGKVDWGNLVPCVEWVDEDYDYLQGKHDHDFTLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9C0</accession>
    <name>A0A317X9C0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10 12">Alpha-glucuronidase</fullName>
            <ecNumber evidence="2 10 12">3.2.1.139</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">aguA</name>
        <name evidence="16" type="ORF">BO94DRAFT_510520</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 12">
            <text>an alpha-D-glucuronoside + H2O = D-glucuronate + an alcohol</text>
            <dbReference type="Rhea" id="RHEA:20005"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:58899"/>
            <dbReference type="EC" id="3.2.1.139"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 12">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10 12">Belongs to the glycosyl hydrolase 67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.139" evidence="2 10 12"/>
    <dbReference type="EMBL" id="MSFK01000005">
        <property type="protein sequence ID" value="PWY94232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9C0"/>
    <dbReference type="STRING" id="1450535.A0A317X9C0"/>
    <dbReference type="OrthoDB" id="6501611at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046559">
        <property type="term" value="F:alpha-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02795">
        <property type="entry name" value="CBM6-CBM35-CBM36_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1330.10">
        <property type="entry name" value="Alpha-glucuronidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037054">
        <property type="entry name" value="A-glucoronidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011395">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005154">
        <property type="entry name" value="Glyco_hydro_67_aGlcAse_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011099">
        <property type="entry name" value="Glyco_hydro_67_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011100">
        <property type="entry name" value="Glyco_hydro_67_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39207:SF1">
        <property type="entry name" value="ALPHA-GLUCURONIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07477">
        <property type="entry name" value="Glyco_hydro_67C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07488">
        <property type="entry name" value="Glyco_hydro_67M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03648">
        <property type="entry name" value="Glyco_hydro_67N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029900">
        <property type="entry name" value="Alpha-glucuronds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10 12" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10 12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016189678" description="Alpha-glucuronidase" evidence="10 12">
        <location>
            <begin position="21"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha glucuronidase N-terminal" evidence="13">
        <location>
            <begin position="26"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 catalytic" evidence="15">
        <location>
            <begin position="148"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 67 C-terminal" evidence="14">
        <location>
            <begin position="471"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR029900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR029900-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY94232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="842" mass="93362" checksum="F9090A18F8B6F5E7" modified="2018-10-10" version="1">MRGFAYTSLALASIWSLTAAEDGYNGWLRYAPIPCDLSCLQALPSHVVLLNSTRGNPIETAGRELKAGFQSILSKNLSSLPLQCDSPASILVATVDEYRQRCNGNITVPALDDDGFWLQSRGDTVRILGQNDRGALYGAYEYLSMVAQRNFSHVAYASSPHAPIRWVNQWDNMDGSIERGYGGASIFFENGTVVDDLAPVEQYARLLASIRVNAIVVNNVNANATLLLPENMKGLARIADTCRPYGVQIGISLNFASPEDVGSLDTYDPLDSGVIAWWQNITDSLYTYVPDMAGYLVKADSEGQPGPDTYNRTLAQGANLFARALQPHGGVLMFRAFVYDDNLNESDWKADRAKAAVEYFKDLDGQFEENVVVQIKYGPIDFQVREPTSPLFANLYHTNTAIELEVSQEYLGQQCHLVYLPPLWKTVLDFDLRVDHQPSVVRDIISGERFNRSLGGWAAVVNVGTNRTWLGSHLAMSNLYAYGRLAWSPTDDSEQILQDWTRLTFGQSHQVVDTITDMSMASWPAYENYTGNLGIQTLTDILYTHYGPNPATQDNNGWGQWTRADHLSVGMDRTVGNGTGYTGQYPEEVARVYESLEATPDDLVLWFHHVPWNHRLHSGETVIQHFYNAHYAGAETAQGFISQWESLKGLIDQERYEAMGTRLVYQAGHSIVWRDAIVNFYYNMTGIPDVYGRVGHHPWRIEAESMALDGYELYTVSPFEAASNTTAIVTTSNSTTGVARTTLQAPSGTYDIGVNYYDLYGGQSHWTLSVNGNVVGQWLGDMDHHSLGHTPSIYLDGHSATRVTFKGIEIQQGDELKIVGQANGVEPAPVDYVVLLPPGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317X9J2</accession>
    <name>A0A317X9J2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain alcohol dehydrogenase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_531081</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025471930.1">
        <property type="nucleotide sequence ID" value="XM_025610822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317X9J2"/>
    <dbReference type="STRING" id="1450535.A0A317X9J2"/>
    <dbReference type="GeneID" id="37112965"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="273" mass="28285" checksum="8186A2479A37C0D7" modified="2018-10-10" version="1">MSTRSIAILGCGGMGLAIARRLGVGRRLYIADFSKEILSTAQETLTNDGYTVETFQVDVSDYVSVSRFAQAAASHGPIEAVIHTAGLSPSGSSAQKILAVNLLGTANALEAFLEVSQSGTSMVCTASMAGHMGSGLPVELERHLATAPRNQLLEHVALKIDKADPHGPARAYGLSKRGNLLRVQASAKAWGRVGGRVNSVSPGVISTGAGRQEIDGPAGKFIAMSPVGRVGTPQDIVNAVAFLASAESSFITGNDILVDGGVVSSLRWDTLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XA99</accession>
    <name>A0A317XA99_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_553237</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000003">
        <property type="protein sequence ID" value="PWY95325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472086.1">
        <property type="nucleotide sequence ID" value="XM_025613643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XA99"/>
    <dbReference type="STRING" id="1450535.A0A317XA99"/>
    <dbReference type="GeneID" id="37115786"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF14">
        <property type="entry name" value="GABA PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY95325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="47571" checksum="D5B8DD8FEC6FC769" modified="2018-10-10" version="1">MSSEACPSSCLSGFRQGVFRLFFTDWGAYHYACFLVPDQYRRQVAYPLGWMKYLGCCAIVATLVLGLVNLCRPEFDVTSRWKLFLVYLAVNGLCWLCNLWGVKGIPTLELIGCYATALGFVAFTTTLLVKALKADPSFVFVDINNDTGYSSNSFAVLLGMFTSFSTLMGLDGPAHLAELHQPKKPLPRIMLIVIFSQFVVGVVWIIVLGFSITDLAAITKTATGVPILELIRRATGSNAAAIVFCLIVIINNTASALGSAVTMSRQGYAFARDGGLLWNSKLIEMSPGSHMPFWSINLPLFLVAAVGLIFGFPSLVLLVTRGRLLPENDRWNFGTWSIPIYGIAVGYSVLVVIVSFIPQSHPVTAVNVNYTVLVMGCFAIAMGLGWVFEGRKLFSPPVNDEVVVATSSTLDGLDVAEEEVIIDGITNGQDKYHSSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XAP5</accession>
    <name>A0A317XAP5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PSP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_454497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472340.1">
        <property type="nucleotide sequence ID" value="XM_025607611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XAP5"/>
    <dbReference type="STRING" id="1450535.A0A317XAP5"/>
    <dbReference type="GeneID" id="37109754"/>
    <dbReference type="OrthoDB" id="243127at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047767">
        <property type="entry name" value="PSP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43830:SF3">
        <property type="entry name" value="PROTEIN PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="3">
        <location>
            <begin position="665"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="433"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="285"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY95579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="888" mass="96420" checksum="959676C068EC6B16" modified="2018-10-10" version="1">MAAPSSKPSSQVTKSVTSSTPTSNVSARLEKTHPGVRRSTPDSEALASSDDDGDHSQQIAASASMPAPKPARRTSWLNEIPATITRKASLTTNGPLSSGASIPSSPATDQSGWPNTSPGIGSSIAWNHAGNSSFPWGTGIWNTESRKEPPPRLAEIVPSPTMSSASNYFTEDLMSPTTRTTAGDSAIPFSIPLHPTPKTYRSQSYSVGQLDPEFLNFMANKSSTPYSGGRPRNGGQYSALQHRSSRPSLLGELGHDPATLGRVREDDDDDAGSPDGSDGSFSNYAANQARTIEQLSRENALLRQAAGQMDNTMRDRAMSSASAASGYVVGNGLHNLHRIRGSVPEETDLAVEDLDEVGDIPGYNNIHSSARRRLSEHSANLEKQFAPMTPLENRALENVRKGHWQTTLGFGSMVDIPQSRRHSFADIPIRHASVSGESQAAASSRAGMGDREEDYGNIADGPLSTVQGQNREYPRFHVAPRPEEHEMETEYLRARRFAEAYFARDPALRAADGPSPVATSLHQAYTMPNAYGRHQPGLAHPHQNQLLYIVTFKCHRADVFYIQEDTGLQVKPGDLVIVEADRGTDLGTIQHANVSMQRARELKQQYAEEHYKWLMMFSRQGQNGAANVVNASGGVPGLNNRSAIGGMGPHGPHGLQDSAADIKPKLIKRLAQNHEILTLRDKEGNEAKAKRVCQQKVSEHRLNMEILDAEFQMDWKKLTFYYFADSYINFNSLVTDLFKIYKTRIWMSAINPASFVTPPSAGLSAPNPLAYSHDAPVDRSLDNRIYGHAREGMDTGRDAGANQMGMLRNAYTESYQTFGQASRQPEPGLGGLASADPFSSPYSPNGYGPLDSGYVDYGAGTGTSAGPSRLHTAPTEWVGRFQGLSLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBI7</accession>
    <name>A0A317XBI7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_507372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472697.1">
        <property type="nucleotide sequence ID" value="XM_025609607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBI7"/>
    <dbReference type="STRING" id="1450535.A0A317XBI7"/>
    <dbReference type="GeneID" id="37111750"/>
    <dbReference type="OrthoDB" id="3437405at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY95936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="701" mass="79682" checksum="D00FA4C565FF5A77" modified="2018-10-10" version="1">MASRLISRSILRTGRSLHAPLPAFRHASHPLTRTRTRIPSDATVHHISPSRMYQSTRWDDDSDPTGYSATTPKGRIGRYPSNVDAMALEGKGITRVHWGNQYLSIVDRLIPPQTIIQFIECLMHGTLPNGKETERERLEQEEFGLLSVPVAQWAGTSSPGGEESILHRIMVVVGSHEDPRRLCTVGKNIHSVKTRLWEGMVPMSAARWQDKGLSEREYFDTACEYLTAVITAFEYLNNHQVRANLRDGFNLISDHLGMFEEALNVKRRERGQKLLDLRGLWEEFIRAKYEVMTSRAHGWVVDRVKELQEKVIGEICALPVMNEEEISQEMEKWTTKLFHVMEITSLADMTIWMPMEGYAGYQPSEDVVAGLRNPNLGDYRKNYSDKLQAIVWPRMEQLIQEQLSKQPDDSNGQSPESRAKRFAVNTIAQDDLRQEIRGPAPVLVPEAWIQRILHFHELSQSVEEEVRMSEGLAIYRLAYQVSDAEWEACKGKLEAHLASWGAGVDKAEEVKPLLKIHWFDGKELGFGDHDIDAAKKHYLEIRDSDAYVQKLQHDVFLVADGWSIASYKESGFHSPTKAMLPGDFQGHILAVDASFDPAAPNEHAEESPGFDGQMRILGNLVWSDLYAMLALRCGGLEDMWPLAMDHPQKAYTGLTVPLQRKEWAEENAITAAVMKPFLEHLKEKHPEMAPTVEKLMMPHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBM4</accession>
    <name>A0A317XBM4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_530713</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472737.1">
        <property type="nucleotide sequence ID" value="XM_025610729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBM4"/>
    <dbReference type="STRING" id="1450535.A0A317XBM4"/>
    <dbReference type="GeneID" id="37112872"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="331"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY95976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="460" mass="52046" checksum="25C79D337B54E8F0" modified="2018-10-10" version="1">MAASTSPVAGPGATRKSKPHITETPITWANWYQHVNWLNVYFIIMVPLMGFVAASFYPLQRATAAFAVLYYFNTGLGITAGYHRLWAHTSYRASTPLKIYLAAVGVGAVQGSIRWWSRGHRAHHRYTDTEKDPYSVRKGFWYSHIGWMVMKQNPKNIGRSDITDLNEDPIVIWQHRHYVKLVLFMGLIFPTLVCGLCWGDWAGGFIYAGILRATFVQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDYRNAIEWWQYDPTKWAIWTWKQLGLAHDLKEFKANEIEKGRLQQQQKKLDIRSSQLDWGTPISQLPVMTWDDFKIEAAKADGRALVAIAGVVHDVANFIKQHPGGKAFISSAIGKDATATFNGGVYRHSNAAHNLLSTMRVGVIYGGGEVEIWKRDYTEKQNNFIMQDSKDQPIVRAGEQVTKIAPPQNSPMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBQ1</accession>
    <name>A0A317XBQ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PA and RING finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_454719</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY95755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472516.1">
        <property type="nucleotide sequence ID" value="XM_025607617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBQ1"/>
    <dbReference type="STRING" id="1450535.A0A317XBQ1"/>
    <dbReference type="GeneID" id="37109760"/>
    <dbReference type="OrthoDB" id="5357315at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04813">
        <property type="entry name" value="PA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000364">
        <property type="entry name" value="Protease-associated PA domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051826">
        <property type="entry name" value="E3_ubiquitin-ligase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765:SF406">
        <property type="entry name" value="PA AND RING FINGER DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22765">
        <property type="entry name" value="RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016355178" evidence="8">
        <location>
            <begin position="29"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="734"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="295"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="401"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="784"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="315"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="655"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY95755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="880" mass="94296" checksum="62EEC54BC1FA632D" modified="2018-10-10" version="1">MRPPRLLLVVFCLIFLPILLTFFSAVTSSPRVSTPSSLAGRATGLHALFSFNIPSSLFPPSAIISLTDDNSTFFLARPAAFGPLLPDKGLSGQLWIGSGFGERTAAGAEGELGCSDIPGWGEGDSPKPGAGADNALGKSGSTPGNEPTVSQGHRHANPQPDADLQHDSKTKTTSPLTNDGTDDHLHHPLPESKVSDPGSIERHGEHYPNRQAAHADIQSLQESAEIDGKVVLLSRGGCGFLEKVKWVQRRGGIALIVGDDTRGGSLVTMYARGDTSNVTIPALFTSHTTAHLLSSLVPPQGEDSGADDGSGPHTKISSHGSTGKQRIDATATTSVIPSPTSSHKAVTHDSAVPARPKSGFFHALLSLFGLGNHGGPAWYPPEDSRRPPSSGNINWILLDHWDDQEPSQDDVERKSSRTKADGAAENHKKSGAQSSSTDGDGFVIGVQDWRDPDLVVPKGSALPSPTSTTETDGSKVQTSVKGSHPTSATLKGGSITPGSGEYRTVEKSSIEKESKMKDFGRKPPLEDVKKGSSSQRTSWFSRHFLWATDDEPDLNPSPRVHGQMAEDQELHEATSQSRQGVNAAEHDGLWVTLTPTSMSTSPFFDTLLVLVVSPLLTLTVVYVLLLLRSRIRRRRWRAPKSLVDRLPVRTYHTITTSSSGTSSPRSVSPGPVSPTSPLLGAKSRSGRARLASRSQQESHANEATSASKMSSSRKEKSGTSTLWRRKYTGRQVECVVCLEEYVDGQSRVMSLPCGHEFHAECITPWLTTRRRTCPICKGDVVRSMSQNKAAETHESTEPSIEDEYRHDLDSQHSASSAPVPIAGVSEDETSDLERHAGSEAGLVEGQASSAPPSWRNFAALSYSALSGDTIWHQAQTEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XBU1</accession>
    <name>A0A317XBU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_507489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000002">
        <property type="protein sequence ID" value="PWY96013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025472774.1">
        <property type="nucleotide sequence ID" value="XM_025609617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XBU1"/>
    <dbReference type="GeneID" id="37111760"/>
    <dbReference type="OrthoDB" id="4499469at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="190" mass="20964" checksum="D8A1336392AC0E0A" modified="2018-10-10" version="1">MGLTADNAVAKLVEVSSLAHHRGRLRVAEKKRADDALQLLANGRPPADAKGAKQRIIYMETLLGIRKEFGDVGVILCAAGLGIGAIANMRDSERVFLRSKLREKWDKLSLDIFQTYADLLDQDTPLSSVAGDVYELSMEDVQKIVAMPGQITGIIRLTEPYNGYQSPFVTIPLSKELAESLIVNRERILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XCV4</accession>
    <name>A0A317XCV4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_580224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473134.1">
        <property type="nucleotide sequence ID" value="XM_025615311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XCV4"/>
    <dbReference type="STRING" id="1450535.A0A317XCV4"/>
    <dbReference type="GeneID" id="37117454"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="136"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY96373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="268" mass="30296" checksum="6F5A9F1927EF78D7" modified="2018-10-10" version="1">MSLRKTSINVLIALTMGYIALFSHDHLFHRSGPNAPENTSTSAAGLVGDEPSYDVQIFSRDPLILHIRDFVSRAEINHLLKISEGTYEPSKVYPEGNHHINRLSRVSESAVLPQDPIVRRIKKRAQRLQGWRGNDTVLERLKVQRYAVNGFYSWHYDWHGNLPEGDRVTTLLVYLVGNNCTGGGTNFPRLKRPEDPRWCQIIECENDEYAGVTFKPIEGTAVFWENMHPNGSVHYDVLHAALPVKSGQKVGLNIWGFDLGWKAPSVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XDU1</accession>
    <name>A0A317XDU1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_506148</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473460.1">
        <property type="nucleotide sequence ID" value="XM_025609562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XDU1"/>
    <dbReference type="STRING" id="1450535.A0A317XDU1"/>
    <dbReference type="GeneID" id="37111705"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12538">
        <property type="entry name" value="RRM_U2AF35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000066">
        <property type="entry name" value="Splicing factor u2af 23 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY96699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="209" mass="24331" checksum="B192A7F6718CD1C5" modified="2018-10-10" version="1">MANYLASIFGTEQDKVNCSFYYKIGACRHGDRCSRKHVKPSYSQTILMPNMYQNPAYDPKNKMNPSQLQNHFDAFYEDVWCEMCKYGELEELVVCDNNNDHLIGNVYARFKYEEDAQAACDALNSRWYAARPIYCELSPVTDFREACCRLNSGEGCVRGGFCNFIHRKDPSNELDRDLRLSTKKWLKERGRDARSVSRSPSPEPTRRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGG4</accession>
    <name>A0A317XGG4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NPCC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_7676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473139.1">
        <property type="nucleotide sequence ID" value="XM_025617659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGG4"/>
    <dbReference type="STRING" id="1450535.A0A317XGG4"/>
    <dbReference type="GeneID" id="37119802"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY96378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="314" mass="33741" checksum="9C82EE742BC8B57A" modified="2018-10-10" version="1">MASPAPPSTPNKAASAPAPTPDGSQTPGKWRHPHLDEVVRRQNAGTFGDRNVNRLMWNTAALFATWVFGETFKSYSVWLQKFSQLPTYPDLSLLALRLIFALNILVALYPLFRPKDNFADIPLTPTQRSLLGLDPSSTQSLTPGSTYVTPPRYRLSASRNASPASRSGSPFSASAGASGRRLSSGASYSPSLSPLMQKLVATGGKEGGRRPSFGASSTLGRSSSFSPFKESTSTFKDSTSSFRESTSSFRESTSSFRESAFRESTMSTISTLSTMSSIAPATPSPVGGKRVNLGLSNKWLYERSRRLSASNGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317XGM1</accession>
    <name>A0A317XGM1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_529864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000001">
        <property type="protein sequence ID" value="PWY96478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025473239.1">
        <property type="nucleotide sequence ID" value="XM_025610541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317XGM1"/>
    <dbReference type="GeneID" id="37112684"/>
    <dbReference type="OrthoDB" id="5126078at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY96478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="65" mass="7165" checksum="B378A97ABA8731CB" modified="2018-10-10" version="1">MNHGAIARGLITYANLPLYNRARVNFPPPADYSPPKESVAVQVLENVLNKVVFTGDKYSTVFVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UUR8</accession>
    <name>A0A317UUR8_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BO94DRAFT_540952</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="MSFK01000081">
        <property type="protein sequence ID" value="PWY64287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461275.1">
        <property type="nucleotide sequence ID" value="XM_025613024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UUR8"/>
    <dbReference type="STRING" id="1450535.A0A317UUR8"/>
    <dbReference type="GeneID" id="37115167"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="37"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="PWY64287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="370" mass="39881" checksum="E6A6B8EE13E4259E" modified="2018-10-10" version="1">MFRQSIRRFGTTALRAAEGTSYNVRVSKAQGFVNGLTEAIGNTPLIRLKKLSDETGCNILGKAEFQNPGGSVKDRAALFVVEDAERKGLLRPGGTVVEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPQNYNHQARRHAESLDNAVWTNQFDNTANRQAHIETTGPEIWAQTNGQVDAFTCATGTGGTLAGITRYLKTVSDGKVKSFLADPPGSVLHSYIQSGGNLIDRTGSSITEGIGQGRVTDNLQPDVGLLDGSLNIPDEKSIEMVYRCLDEEGLYLGASSALNVVAAQEVAKKLGKGHTVVTILCDGAYRYADRLFSKSWLEMKGLRGAIPKHLERYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVI4</accession>
    <name>A0A317UVI4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_591526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000078">
        <property type="protein sequence ID" value="PWY64507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461302.1">
        <property type="nucleotide sequence ID" value="XM_025616115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVI4"/>
    <dbReference type="GeneID" id="37118258"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY64507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="152" mass="15902" checksum="63511294B40EDA02" modified="2018-10-10" version="1">MTVGDGAVAVDDRLEAVRRPARPADVPPSLPGTASRAPPSHPGAPASTLPPPTREWHPGRLPPRRRAPPLPVFSRGASHDSISPSQLANPLCQHAPLRGPWTPAPTLTRNRGAPGTCLAPAVSAGRPAALALQVLRTHVACHRACKRSGVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UVN3</accession>
    <name>A0A317UVN3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Deoxyribonuclease NucA/NucB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_614214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000056">
        <property type="protein sequence ID" value="PWY65685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461512.1">
        <property type="nucleotide sequence ID" value="XM_025616727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UVN3"/>
    <dbReference type="STRING" id="1450535.A0A317UVN3"/>
    <dbReference type="GeneID" id="37118870"/>
    <dbReference type="OrthoDB" id="2748312at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029476">
        <property type="entry name" value="DNase_NucA_NucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14040">
        <property type="entry name" value="DNase_NucA_NucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016355163" description="Deoxyribonuclease NucA/NucB domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Deoxyribonuclease NucA/NucB" evidence="2">
        <location>
            <begin position="92"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY65685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="246" mass="26852" checksum="92237A01DA7B7D8A" modified="2018-10-10" version="1">MRTAIVLLTALLWAPGFYQVLAFPTGTAKPLEARSTVGNTKSNPIQAEIEIRGEDALTYDVDCWAMLCKGKPAIMQKTDTKAADKHRQVKNGSAAKKQPFVHRAKYGIKSSPPTSTWANNQGWVSAEEFPFASTVDGGAGAILVGVTLNSQEEQKNSLHSFYSKNKIQSYNATAKGSDRSWFEITGFKVTPGKTAIIGPYCKAFNAKDKGNLCSASTKVVGDWGFDVAEYAYVYNHQTKTFDYVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UX62</accession>
    <name>A0A317UX62_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_540694</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000053">
        <property type="protein sequence ID" value="PWY66136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461591.1">
        <property type="nucleotide sequence ID" value="XM_025612970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UX62"/>
    <dbReference type="STRING" id="1450535.A0A317UX62"/>
    <dbReference type="GeneID" id="37115113"/>
    <dbReference type="OrthoDB" id="4056921at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.457.50:FF:000001">
        <property type="entry name" value="Probable kinetochore protein spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="4 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="6 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="14">
        <location>
            <begin position="183"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY66136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="258" mass="30098" checksum="B36CB4CD73F3EFB1" modified="2018-10-10" version="1">MNPSFDPSLSTSGMRPPLTSADAPSMADSLPSINFGFEDLRNRMAQFTARFDAFIERGRKQVLEERNQFKIGLAELQEDERMKQRDIEILDLKSQTHQQTLQKEAAEAAEMHAAISSVALERDSRLAKRDRLKQQIDETQKAISQKQEAQKTHARYLDAQARLNVPELEFWQDYLCLRIEGAGREDRLKFVYTHLLEKDWEAEAWFELGTASRDYAVFHTRPKVNREALERELDIVNEDRDFGAFLKRMRRLFVDTMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UYT5</accession>
    <name>A0A317UYT5_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fumble-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_528234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000048">
        <property type="protein sequence ID" value="PWY67233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461877.1">
        <property type="nucleotide sequence ID" value="XM_025610415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UYT5"/>
    <dbReference type="STRING" id="1450535.A0A317UYT5"/>
    <dbReference type="GeneID" id="37112558"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24123">
        <property type="entry name" value="ASKHA_NBD_PanK-II_Pank4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000115">
        <property type="entry name" value="Pantothenate kinase PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.510:FF:000005">
        <property type="entry name" value="Probable pantothenate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00555">
        <property type="entry name" value="panK_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY67233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="438" mass="48517" checksum="F84D10A7177D159C" modified="2018-10-10" version="1">MSSSTPNSVRGGRLEQAITNPGAVKINVKGAFIVDDDPRSKSPVRTDGVHYEGHDIRLPHHTGLVSHVAVDIGGSLAKLVYFTRELDSVDNGGRLNFINFETSRIDLCIEFIKQLKEEHEKLGGPSGDALCVMATGGGAYKYYDKLKAALNVNIIREDEMECLITGLDFFITEIPNEVFTYSELEPMQFAEARPDVYPYLLVNIGSGVSMIKVSGPKQFQRVGGTHLGGGTFWGLMSLLTGARTFDDMLAMADRGDNSGVDMLVGDIYGMDYTKIGLKHTAIASTFGKVFRMKSEAESNQVDGEDTFQGEPSERNGEPTFQFEDMSRSLLYAISNNIGQIAYLQSEKHQVKHIYFGGSFIRGHRQTMNTLSYAIKFWSKGEKQAYFLRHEGYIGAVGVFLRRQPANWGRRNSVDETTMPQVAKAVAELQQKADSQEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317UZV2</accession>
    <name>A0A317UZV2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_335122</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000054">
        <property type="protein sequence ID" value="PWY66052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461562.1">
        <property type="nucleotide sequence ID" value="XM_025607007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317UZV2"/>
    <dbReference type="STRING" id="1450535.A0A317UZV2"/>
    <dbReference type="GeneID" id="37109150"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024145">
        <property type="entry name" value="His_deAcase_SAP30/SAP30L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286:SF23">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP30 SIN3 BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13286">
        <property type="entry name" value="SAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="8">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY66052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="236" mass="25598" checksum="843466D19485396E" modified="2018-10-10" version="1">MAPPRQRTTAVQDDSRSEGSSTAREHKTTAVKARKGAGGSLAVAAMSSREAKVSGNLANVTSAPAGGEQDNSPKIPWSEMPLDLLHSYRHAYKLSTPSAFSSEYAHLLLGRGIGLRSPTAIAAQRAHQSRQDQMTNGSQSSASTSRKALHNHSSAPNGVSTNHKDRRPHKGPDTIDGKSALHHIIGQDRVCKNQLAVTVRKHFNSAGLAEQEAIARFLYKVREEGRGRHFRLRFQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V2J4</accession>
    <name>A0A317V2J4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Na+/H+ antiporter Nha1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BO94DRAFT_590848</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000047">
        <property type="protein sequence ID" value="PWY67581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025461930.1">
        <property type="nucleotide sequence ID" value="XM_025616066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V2J4"/>
    <dbReference type="STRING" id="1450535.A0A317V2J4"/>
    <dbReference type="GeneID" id="37118209"/>
    <dbReference type="OrthoDB" id="5327978at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="25"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="460"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="473"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="605"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="803"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="522"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="556"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="661"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="685"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="829"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="875"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1025"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="PWY67581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="118853" checksum="F38321DB51EB270C" modified="2018-10-10" version="1">MAWDHLDIDKPHVAYMILGGFTSLFMLCSLFVKEKLYIGEATVATLCGIIFGPHAANLFNPLSWGNVDKITLECSRIVLVVQCFAVGVELPKAYMERHWKSVFLLLVPVMTWGWLVTSLFIWWMVPPLSWLESLVCAACVTATDPVLASSVVGKGKFARRVPKHLRDLLSAESGCNDGMAFPFIYLAFYIWRYRPDAGKVSLNWFCVTILYECVFGAVYGFIIGYLARHSIKLAERKGLIDRESFLVFYFVLAVFCAGSGSLLGMDDLLIGFSAGVGFSNDGWFTEKTEESHVSNVIDLLLNLAYFVYFGSIIPWEDYNNPSIGLVPWRLVVIALLVIFFRRIPIMLMLKPIIPDVKTWREALFAGHFGPIGVGAVFASILARAELESDSTEPWSESELPGPGSSNYYIVQLIWPVTTFMVISSILVHGSSIAVFTLGKRINTLTITLSYTTANDEGPSWMNRLPRVQSLAKGSMSFRKPDDVEESSNEPEYPPGTLPPIGVPGNFLRRVRDEDTESTGGRSARRRRRRRRRDDGAGGPISQSAIAPQRTLDTESDEQREKSDESEERDKIEREASPPSKEGEKFGREPALEVYLEGHNMIMEDEEGNVLKVEDVSHMSTEEQQRHMEQQRQKLQEQSDQYAQSRTKPHRRTEGEEIEEAVGEKTGHPLDRARMRFGQWFGFGKSRAEDQDDREAQKIADKKKTEEASRKPKRKGRSAHAYQFGNTIIVEDEDGEVIKKYSIPSTDAPEADAPVRRGLTRMGTWFGMEEEGESSQAARKAAQDDWLADDGLRFTLADDNEVGKRGVEHKGRRMTKHEFAQQIRNLGPKARRDLVEETDAPERVKNVARQEARKADSQERRKSDPGVATQTPVPVADDETGSGSEFSEDESDEDEVAGDIAASLARFTRGTAAEERRSTHLSSPPAPSPKSRPRSRRDSEDDGTERIPPAQLREAAGLSRPPQQADLDDTGETPAERRRRLAALGEINDSDDSDDPDAALESDEESNDIDAGAKVSFADGTKPAGSRQQSGDTSSEGQENSSPYARQSRSHSRRSISWGGEKGREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V3Z2</accession>
    <name>A0A317V3Z2_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_590574</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000043">
        <property type="protein sequence ID" value="PWY68993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462308.1">
        <property type="nucleotide sequence ID" value="XM_025616041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V3Z2"/>
    <dbReference type="STRING" id="1450535.A0A317V3Z2"/>
    <dbReference type="GeneID" id="37118184"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY68993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="623" mass="70352" checksum="8F2BA5847C7AB8B5" modified="2018-10-10" version="1">MDNGPASRPAKRAKKGSACLHCRHMKLKCDLATTASRSCTRCTRTGKNCSDGQVYRRTTNKQRLDTLENEFKRMQQRMEAANTLTPLPQYSHEASEINEWDDWTEETALQNMTSQTLESVTLQGHEILALIKEFYATLHPLFPILPSLPDFIKTYNANRLLLWTVIAVACKESAQYTHLYVTLVDPVRRLAGDLYNTQSRHFETIQALLLLCIWPFPFQQTAHDPSPMYCGLATQLSYQLGLHRPNQHMHWEYGATGSNYRVDLQRRKAWIGCFVVNHIISTRLGTPSAVQPGHAILLEIAKISTSELPAPLLHYAHIAYVGMKALEALGDDASSATGEAKYPIPLVTTFDQKLTTMRESLSSKWSSLAEAFFLETKLQILSFALDEDNYPDSMLAVDLSALTIYDRASTASQRVLELAAMETSETRYWPIFAKHSSMYATIMAFRLACIAQPGSSQQARLQQTILDGVTLVKSWSMFQKDNFGRFCSHMEYLSRKLGKNQKESLPTLWSMGSWQEKQSGFGSPFYKPAVKSRMAANITYDTIWASKHAILEEEQKSRVVYIQDPDQSLRAGLADVHHVSPMRSADVPGLPVDFLLDDNAFLFNESSDIMNIFEDWENLVGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5F1</accession>
    <name>A0A317V5F1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BO94DRAFT_478464</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Microsome membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000045">
        <property type="protein sequence ID" value="PWY68117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462139.1">
        <property type="nucleotide sequence ID" value="XM_025608689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5F1"/>
    <dbReference type="STRING" id="1450535.A0A317V5F1"/>
    <dbReference type="GeneID" id="37110832"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF150">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="PWY68117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="137" mass="14490" checksum="6B26ABB79CAF0C7C" modified="2018-10-10" version="1">MSDAKELTLQEVSAHNTKKDLYMVIHDKVYDVSSFVDEHPGGEEVLLDVAGQDGTEAFEDVGHSDEAREILDGLLVGNVKRMPGDPAPREKAQSSSGPSSSSDGGLGVGLYAFLLVGGLIAYGAYQYLQTASAAETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V5T7</accession>
    <name>A0A317V5T7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_294851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000041">
        <property type="protein sequence ID" value="PWY69653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462481.1">
        <property type="nucleotide sequence ID" value="XM_025606709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V5T7"/>
    <dbReference type="STRING" id="1450535.A0A317V5T7"/>
    <dbReference type="GeneID" id="37108852"/>
    <dbReference type="OrthoDB" id="2748312at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY69653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="76" mass="8265" checksum="5B4C8B2CCB75D434" modified="2018-10-10" version="1">MKKVDKSTVKKHWQVKNGNAANKQPFKHQAKYGIKASPLTSAWANHEGWTSAEEFPFALTASGGVGTILVGVTRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V6S5</accession>
    <name>A0A317V6S5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_503282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000044">
        <property type="protein sequence ID" value="PWY68532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462195.1">
        <property type="nucleotide sequence ID" value="XM_025609468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V6S5"/>
    <dbReference type="STRING" id="1450535.A0A317V6S5"/>
    <dbReference type="GeneID" id="37111611"/>
    <dbReference type="OrthoDB" id="5130616at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056867">
        <property type="entry name" value="LRR_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24969">
        <property type="entry name" value="LRR_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY68532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="521" mass="60865" checksum="8B8AB624C24F7165" modified="2018-10-10" version="1">MTLDNLPGELVLRIIPLLTAHDHTQLVLVCKSWYSLFIPHLYHHVMIPLNYYCGFGFGHISKSLDLPVRRITLALIENPSLALLIRSLELYPSTCKGKWRDGPPLKPLPEEAYRLSMLPYGEAKRKHRRQFHAWRRDLKQRSERQDWYRPYRYEDAWLALLLMQVKNLERFAMELPEERDHLNEEVQLKNSVHFERVIQWASNPNLGVLTRLTHISLTNGPAFWEPGTAVNAVPLNRLVPYLRIPSVRKLYVKNPCDRIRFNMPKNRDLVLPLTHLDIEAPGERLPNLPRLLERYPNLQSFTLEQGELQREHVHNYPDYSLLYQPLQQSQSSLRHLNLTYQSDRTWLDAEIPTPAFFGSLTEFRNLQTVHMRWSNLVPFLGKAAYDPSTPLCELLPHSLQHLYIEDCLIQCSSALCRELENLVTHISETVPMLKTLYLRYAAEEQAPGQGCRECVQGKWPTLRMMEQDPISDGRLLELQGKFRALDVEFRIIERKARVPFPEDGSIRKKWPRGKNGKIVSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317V7I8</accession>
    <name>A0A317V7I8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrogen regulatory protein OTam</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_269572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000039">
        <property type="protein sequence ID" value="PWY70334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462625.1">
        <property type="nucleotide sequence ID" value="XM_025606551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317V7I8"/>
    <dbReference type="STRING" id="1450535.A0A317V7I8"/>
    <dbReference type="GeneID" id="37108694"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="119"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY70334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="723" mass="79645" checksum="D5A5FEB0B3F6D567" modified="2018-10-10" version="1">MAAVITLQSSTTTGPTVPSAAAFQPSPASDHQLLRPRVQQQSQPQPSSHAPQPGSTSTPHSPASSIGTLPRVTAPGRDGPSCDACVRRKSRCAINEMVNKCYSCDFHRQDCTFTLSVTSRPGTAEVQSKKRKFDDTDSDEVESPKRQSTLPPVNKPDSSRPTLHNHHLLTPAFWFQSTQHIGLTTELEPALLEFLPLDQNNEGCVASSRVRKFGDDGTFMRVVNTRSHADSPQTATLDAIESLVAPYGSTLVEKFFENVHPTFPVLMEDSFRQSYRARTGLTPLLLSAVYVLALKFVDVGPVSQSIRRPDAGRLESTALKLLTESLPYASMSTVQAGLLLMQRSNLATAALNAQLVTAGFELGLHQDCSNWRMEAWEKGLRKRLAWALYMQDKWSALVHGRPSHIVSSNWMVQDLVEQDFTDAFSGSSQHEDAPVGHGPLSFCHMVALTTILSDILDRFYTLQAIEEFRAAGNNRTRMILERAKPAQIRLKEWFGRLPTQLKMDSGGDLFETVSEDNSRNGALHLAYFATEITLHRCIVRSLSPDTADAYLSHICRSAAKTRLISAMDFVNRLRPTHLRSFWPAAARTNFALIGSFGVLLRVTAPTKEESEFYRLRLCEYRWTLSVSKKDAEFLEFALDSLDSATNLDHYVPEKPGIDELMTSAAKPTINPPRMGAQLEDSILEIEQTGDSGLGGTSSVISGLASPATSISDESLQDTSIPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VB43</accession>
    <name>A0A317VB43_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_260387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000036">
        <property type="protein sequence ID" value="PWY71573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025462971.1">
        <property type="nucleotide sequence ID" value="XM_025606485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VB43"/>
    <dbReference type="GeneID" id="37108628"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016351460" evidence="2">
        <location>
            <begin position="32"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY71573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="117" mass="13140" checksum="5DB933EB7EB097AF" modified="2018-10-10" version="1">MQWSSHHLGTRFPACRTFFRFLCSLLGTSHPQDRTSSYPKSRNPPGPHKQLDRWLKYMITPCLAKPPGRTPSGLLESSCTFGDQLRPRWSGQTGGSAALQLECAKLARSRRRPGCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VC21</accession>
    <name>A0A317VC21_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_560231</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000035">
        <property type="protein sequence ID" value="PWY71776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463012.1">
        <property type="nucleotide sequence ID" value="XM_025614133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VC21"/>
    <dbReference type="GeneID" id="37116276"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF1">
        <property type="entry name" value="HYPOTHETICAL O-METHYLTRANSFERASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="109"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY71776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="294" mass="32775" checksum="5F7B0EAFBC8EF3E4" modified="2018-10-10" version="1">MIAVEGGMLHALASRPGQVCSADQLAHWTHRPRNDIVRALRLLTAVGVCDEAGPQSYRANDKTSVLATKGQIGGLRVSSVPVSGIIPKIEEYFTNRATSTQSAAALASPYAYTYGKPMYDVLREDKEKKTAFDDYMEGRKQERKRRWHHTYPTMSELAAAGALTDSTPITIVDVGDLPETVDPIRGETHSFEPMPYDFFTPQPVQGATIYLLLAVLHNWDDDACRAILKNLAAAMKPGYSRLLISGVLLPEVGAERRLADLDMQMWVLQLAQQRTRNFWDQYNTDQSSIHDVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VCZ9</accession>
    <name>A0A317VCZ9_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_501202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000034">
        <property type="protein sequence ID" value="PWY72136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463089.1">
        <property type="nucleotide sequence ID" value="XM_025609425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VCZ9"/>
    <dbReference type="STRING" id="1450535.A0A317VCZ9"/>
    <dbReference type="GeneID" id="37111568"/>
    <dbReference type="OrthoDB" id="2799468at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007011">
        <property type="entry name" value="LEA_SMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04927">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP" evidence="2">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="SMP" evidence="2">
        <location>
            <begin position="121"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY72136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="169" mass="17817" checksum="DC33427695D1DEFB" modified="2018-10-10" version="1" fragment="single">MSSELPDIVGLKRAVERGQRVGPEDVSALAQTESELTGAGPIRGGTAATAQSLAMKQMNFDEILDELSRKPQSHITQDDARELYAAEGRAFNKPPGPGSIAAQVRSIADRNEALGVPAVPGEAPVYITKEDASEAQHAESTIYGGQNPRGGIAAQMQSAADKINNAHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VFI0</accession>
    <name>A0A317VFI0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BOD1/SHG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_539022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463409.1">
        <property type="nucleotide sequence ID" value="XM_025612615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VFI0"/>
    <dbReference type="STRING" id="1450535.A0A317VFI0"/>
    <dbReference type="GeneID" id="37114758"/>
    <dbReference type="OrthoDB" id="5579731at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055264">
        <property type="entry name" value="BOD1/SHG1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034:SF1">
        <property type="entry name" value="NUCLEOMORPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28034">
        <property type="entry name" value="SET1 COMPLEX COMPONENT SHG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05205">
        <property type="entry name" value="COMPASS-Shg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BOD1/SHG1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY73144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="795" mass="96248" checksum="F62A0B78DB178051" modified="2018-10-10" version="1">MAGPEEMSDTLVAVGTKRSSSLDLDLDSLQRKKFKTDELPLSAAQHTAIENLLHAFKKRGGFDHIRKKIWAEFHDGEGKVEFTKLLVELAESEIDREPGLLARERGKAATLIEGAVDRSDVYKSVENSLDALAEKFLLDILGSVREIRRDEIGEELAVQEERAGNKTDEDYAIQVKAKRDEREKVWQEELRKQKEIEEEEARKKAEEDRKRREIERQKEEEERARRREREEQRREEQRKLDEQREKERQERYERRRREERERYRDWRDRSRTRDRDSDRDRDRDRYRYRDRSQGYRSDRAHSPRYRESRKDKSPTPKEPTPAPVPPPPPVDEKSLEETALQLLLKEGEELAAKARQKPEFDFEEAEAIENGLKPPPKGPKAESRYSNTPTRAGSPPGDADANRTRGSTADDRNRTRKREDSRSRSRRRFSSRFDDPDKSRDVSSQPRNRDSDDRLVLRDFRDNRYGDRSYRPNRRSRSRSTVRTDRDRDRDRDRDRDRRDRDRDGDRDRDRDRDRHRDDYRRRRSYYSRSRSRPRYRSHSRSRSVHRDRNQDRDRDRDRERTRDQDRDRPRDPERDRPRDPERDRPRDQDRDRPRDQDRERERDRDRPRERDQDHTREQTRERERERDTDDTRPREGEKSPRVPGSSRRRSRSRRRSRSRCRSPSLLDIDRYVPPTSRRSRSPRRRVRSPERPEKEREREQREREREREREERPPPRGFVEIDRYIPGGGAGGGGGNASEQKTEGNNNNNNNNNNNGNRDREREHRDRDREREREREREPDERRPPRRSASRRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VGP1</accession>
    <name>A0A317VGP1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_549897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463360.1">
        <property type="nucleotide sequence ID" value="XM_025613466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VGP1"/>
    <dbReference type="GeneID" id="37115609"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016373696" evidence="1">
        <location>
            <begin position="28"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="135" mass="14360" checksum="1DEAE87AFE77B310" modified="2018-10-10" version="1">MLGLALAPLPSCFLLLLASHCPRTSLSCLCIAGELAPSLLNILCCLVLHPPANLLPQLRLKAQPGGGACVACWSSANASHTPADTDTPADTDLIIHLLILLTPTVPPGPYLYLFRRFLLRMIPIPSNSFLGARII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VH83</accession>
    <name>A0A317VH83_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_550103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000033">
        <property type="protein sequence ID" value="PWY72527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463301.1">
        <property type="nucleotide sequence ID" value="XM_025613478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VH83"/>
    <dbReference type="GeneID" id="37115621"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY72527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="130" mass="14925" checksum="C7B3B21743E66888" modified="2018-10-10" version="1">MTQTHSKRLRQEEDIGKLVPSRMPSSGQWVESAARMFDQLEHSPTQESDKGRMKANPISVRPLVAFCVWQTTINEIPNGRDIARVVYACVIHFLMSYFSTLHPCKGRNRQQAHQAHEQASTDPRFKPVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJJ1</accession>
    <name>A0A317VJJ1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_578395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000032">
        <property type="protein sequence ID" value="PWY73198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463463.1">
        <property type="nucleotide sequence ID" value="XM_025615212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJJ1"/>
    <dbReference type="STRING" id="1450535.A0A317VJJ1"/>
    <dbReference type="GeneID" id="37117355"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY73198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="469" mass="52792" checksum="694851ABF9D96F79" modified="2018-10-10" version="1">MRRCFPPTTWSLFVFISGTAFLFVGMLVCASAIDKASQDVLWKPTRPDSLIIWPQERSDPDATDSYVITKRIRTEVVSSHRPRGMAPRVQFPPLIIFCIAAGYLMQAISLPLQHWPPQALQFLTTVFMFLCRSFLRRQDLPDRAKRIDTGCCTDWIAKRCLLDPQRLYEPALPGDDPDISWSLSSIKVSDDDAKIRGCRCAQDLLEIREFLARTTQDKGSHTQLASTLALAINEVTLSLADNMNVITSKGIDHWARELEIQVDGQATESLELMIEKHKEGWKADENQLGALISLLLSGINPRKVKVLKMSALTIGPSHENLEFVLRRKNLYDEIGLYQIPPQDSSTGFRVTVEKPSLLGNRDMTGEEDDDEVTFSVSRIGENAHLDKSSGAKLARISKVPVGQLYAQHMFVCFMWTIGKALSTKKDSVKRSDLANDTLFRRIDFTGLSDLNFARVAVMAPLSWYELLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJT3</accession>
    <name>A0A317VJT3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_627427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463786.1">
        <property type="nucleotide sequence ID" value="XM_025617424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VJT3"/>
    <dbReference type="GeneID" id="37119567"/>
    <dbReference type="OrthoDB" id="4453902at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="262" mass="29723" checksum="47A64FE7C0DDF7E6" modified="2018-10-10" version="1">MNCSTENRARLDAVTAIERSLASGFLTQYTPGDLGAHHVEVSTMRLDGDRQPPSQSSFFEPYMGTLPQPDPEEEYPPFDENGGVFCTPIAWAQDIYQYLRAYLMDIAGQENPNDHIQLMQPGNFDYNLWEHDYHFNWRATSASKVPDGPWLKCMILNDIQGSDKITRGELLCICQIMIKGLGTYENHVMAPVLLLSFMGPRHGRVLLAHHDGNKLVIYRTELFDFQSRNVSAFKILARWWCSGGVGNTVTRKPNIVQKALKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VJW0</accession>
    <name>A0A317VJW0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Antiviral helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_500086</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463769.1">
        <property type="nucleotide sequence ID" value="XM_025609406.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317VJW0"/>
    <dbReference type="GeneID" id="37111549"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1500.20:FF:000001">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="329"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="644"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="536"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="575"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY74576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1291" mass="144323" checksum="D013D198B87A5302" modified="2018-10-10" version="1">MTGSLTSALAELSLNSQSLSGPAFDARLAEEEAGVYRNCKPRQRAQQNAADLKEELERDFLTPSSKFSPEWLNRLQRKWDVSTDYTDLFEVAGTQTRTIVRFDRDGLEGRVTGYHEVTVPAISANAKNSTSLLRRPAGRADFVRGAAGFFPFAPGGLDGVEAIAEMESEAQTTEHSRTGKQSGLDRIINFGAEGGLLEIAPGFSRGLKFEEAKTKEVADGDKEVEDALQQEETELHVEQDETASDAGGVKIEDEAELSDEEDIDSLLPVEFPALEPHAPLLAGVQQRKTGREWAHVVDVNKEITNFRDLVPDMAREWPFELDTFQKEAVYHLECGDSVFVAAHTSAGKTVVAEYAISLAAKHMTKAIYTSPIKALSNQKFRDFRTEFDDVGILTGDVQINPEASCLIMTTEILRSMLYRGADLIRDVEFVIFDEVHYVNDLERGVVWEEVIIMLPEHVTLILLSATVPNTYEFASWVGRTKKKDIYVISTAKRPVPLEHYLWAGKGKYKVVDSNKRFLENGWKEADEIISGRDKVKAQKAAEAQAQSQASRGAPQGRGRGQAGGRGAPRGGNSQRGGAPRGRGQPANRGTGNIARTGRGGGRTTAAQDKTVWVQLVQHLRKENLLPGCIFVFSKKRCEQNADSLSNQDFSTASEKSLIHMFIEKSLTRLKPEDRTLPQILRLRELLSRGIAVHHGGLLPIMKEIVEILFAKSLVKVLFATETFAMGLNLPTRTVVFSGFRKHDGKGFRDLLPGEYTQMAGRAGRRGLDTVGYVIIVNPGRDEAPPAGALRRMILGDPTKLRSQFRLTYNMILNLLRVEALKIEEMIKRSFSENATQALLPEHEKQVQLSEASLAKIKREPCDICDIDLAACHAAAIKYEKLTSELHVGLLSSPVGKRLFVPKRLIVYRKEGFRTAGVIFREGIGGGQAPSIQVLEIGRIGNRRHPSDILPFLPRFKQLLQSLPTRAADMALKTYKVPLLDLECVTNTVVKLGGPIWYLNIKKEAIKFADKELSKYCTSWTSPVWDEMDWARIKELQVRDILEKRQAQASIAQSCKCLQCPSFLKHFEMQHDEWQVKENISQLKQLMSDQNLALLPDYEQRIQVLKDLGFVDEQSRVQLKGKVACEIHSADELVLTELILENVLAEYEPEEIVALLSAFVFQEKTENVPTLTPRLEKGKEAIVRISDRVNDFQIQHQVIQTSEDSNDFASQPRFGLAEVVYEWAKGMSFNRITDLTDVMEGTIVRTITRLDETCREVKNAAKLVGDPTLYTKMQQAQELIKRDVIFAASLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VKT4</accession>
    <name>A0A317VKT4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_559662</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463698.1">
        <property type="nucleotide sequence ID" value="XM_025614086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VKT4"/>
    <dbReference type="STRING" id="1450535.A0A317VKT4"/>
    <dbReference type="GeneID" id="37116229"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF190">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016399401" evidence="10">
        <location>
            <begin position="28"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY74505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="496" mass="56558" checksum="4CA2DB0B4A6E5585" modified="2018-10-10" version="1">MTVLTIPTLSAVALCLFLAVFVRRALPGRDIPGPVMARYTRLWYIWQMIKGDFQYTNMKLHRDHGKIVRIAPGWYSLNDIDALKSIYAHGSRFIKSEWYEAWNFSPDPQDHNLFSVRNTAHHSDARRKVASMYSMSAVVSYEPYVNDCIRRFCAQLDSFAKAGSMVDLGHWLQCFAFDTISGITYGERIGFLDQGQDINNLMANLEKNFLFSSLTGLMLWLRPVVLFLGKFFASSDTLFVRRFTDQKFTELSQKGDQKPSTETLPMIQRFLHAQRDEEKGLTDRYIKVSAASNIGAGSDTTAIGLSAAVFYLYRSPDKLAKLRQELDDAFIEGDPSFPETQKLPYLQAVIKESMRLHPGVGFPLFRLVPRGGAVICNKFFPEGTNVGINSWVMHRDEKIWGGDADNFVPERWLSNNTETLRMMEQCLMPFGLGSRVCVGKNISLFEINKLIPPLVLNYDIEIQQRDGKDMKARNMWFVKPVQFQGTIRSRPGRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VLR9</accession>
    <name>A0A317VLR9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_524214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463940.1">
        <property type="nucleotide sequence ID" value="XM_025610253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VLR9"/>
    <dbReference type="GeneID" id="37112396"/>
    <dbReference type="OrthoDB" id="4177740at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY75313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="263" mass="30745" checksum="7F0176E5C83BDEA6" modified="2018-10-10" version="1">MNHIIEPKERYNLRKALTLMEREIKVLKETETHTLDQSILKQYKIRTLPLSLRVDGPLSPKFFTPLVSDNIPEPTAEYVDHEYYTEPTLWSSEWGRSIYMYLDAYTRKLALQFPEIWRVWSCKNIGDYNFGDLYRTFEPVFGTLFIWHVAKASKPHIKCIMHNDLDVDDDHLLRGKVLTVIRIMLGQLKQKVFVTQMIAPVLLFSLNRRHPRVIEAYFDGHELVVCRTKAYDFTSMNAAGFKTLAQWWVGDAVGDTSTRGIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VMQ7</accession>
    <name>A0A317VMQ7_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RraA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_474537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463704.1">
        <property type="nucleotide sequence ID" value="XM_025608519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VMQ7"/>
    <dbReference type="STRING" id="1450535.A0A317VMQ7"/>
    <dbReference type="GeneID" id="37110662"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF28">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="226" mass="24367" checksum="F0C1C03D1153B4A9" modified="2018-10-10" version="1">MAVKPNVLRALQRFTSCDVGDALVKLGVPQGGYLSGLTMYSPGLMSSTAKIFGPAYTVKMVHAADKAPPTPKVHFADAIPQNSVVFVSQPKGLISACWGGLMSTRAQKRGAAGVIIDGKFRDINEHRELGIGLFARGISILGSNTFTRSSELDVPVTYENIENGGEVVINPGDYILGDADGVVVVPPDSAEECVRLCQERYDIDEETRRCLKRGDEIGSTIKRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VNU2</accession>
    <name>A0A317VNU2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_549652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000030">
        <property type="protein sequence ID" value="PWY74522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463715.1">
        <property type="nucleotide sequence ID" value="XM_025613459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VNU2"/>
    <dbReference type="GeneID" id="37115602"/>
    <dbReference type="OrthoDB" id="4451356at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016395842" evidence="1">
        <location>
            <begin position="21"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY74522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="150" mass="15704" checksum="891D92C1F4E81F00" modified="2018-10-10" version="1">MPSWIIQLGALMALAQTISGAEIYIKSTQPPANLYVTHCSVIIEDELFGCKGSSEPFKRSCGRNKGIETKSICKSATVTVDWTTAQLSFKNSDGNTANCTLNSTSSFGHCNTDNPDEYPIETVHKSAASGGLAASAALLGLGTMAAGLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VPT7</accession>
    <name>A0A317VPT7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BO94DRAFT_538249</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="MSFK01000027">
        <property type="protein sequence ID" value="PWY76384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464197.1">
        <property type="nucleotide sequence ID" value="XM_025612450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VPT7"/>
    <dbReference type="STRING" id="1450535.A0A317VPT7"/>
    <dbReference type="GeneID" id="37114593"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000021">
        <property type="entry name" value="calcium-transporting ATPase, endoplasmic reticulum-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="288"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="754"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="787"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="827"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="890"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="PWY76384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1008" mass="109249" checksum="2400EBD351D14E9E" modified="2018-10-10" version="1">MEHSYLSSPAEVLDHFGVKESSGLSQGQVSQSRQKHGPNALAEEPPTPLWQLVLEQFKDQLVLILLGSAAVSFVLALFEEGDDWSAFVDPVVILTILILNAVVGVTQESNAEKAIAALQEYSANEATVVRDGTTQRVKAEDLVPGDIVNVAVGDRVPADCRLLAIHSNSFRVDQAILTGESESVSKDVRTVHDKQAVKQDQTNMLFSGTTVVNGHATAIVVLTGGSTAIGDIHESITSQISEPTPLKQKLDDFGDMLAKVITVICILVWVINIEHFNDPSHGGWTKGAIYYLKIAVSLGVAAIPEGLAVVITTCLALGTRKMAQKNAVVRSLPSVETLGSCSVICSDKTGTLTTNQMSAEKIVYLNQSGDGVEEINIEGTTFAPQGKLSRGGKELQDIAVFSATVRQMAEVMARCNSATLAHDAKNSSFSCIGEPTEGALRVLVEKIGTDDAATNAKLFRQPASQRLHAASAYFEARLPLKATYEFSRDRKSMSVLIGTEKEQRLLVKGAPESILERCSHVLLGADGRRVSLTKNHLDRLSAEVVECGSHGLRVMALASVDSVGNNPLLHNAQTSKDYAQLEQNMTLIGLVAMLDPPRVEVAASIKKCREAGIRVIVITGDNQNTAESVCRQIGVFHEGEDLKGKSLTGREFDGLSNEEKLEAAKIVSLISRTEPSHKSKLVDILQSQGHVVAMTGDGVNDAPALKKSDIGVAMGTGTDVAKLAADMVLADDNFATITLAVEEGRSIYSNTQQFIRYLISSNIGEVVSIFLTAALGMPEALIPVQLLWVNLVTDGLPATALSFNPPDHDVMRRAPRKRDEPLVGGWLLFRYMVIGTYVGVATVFGYVWWFVYNPEGPQISFWQLSHFHKCSSQFPEIGCEMFSNDMSRSASTVSLSILVVIEMLNAMNALSSSESLLTFALWNNPMLVFAIILSMALHFAILYVPFLQGLFSILPLDWMEWKAVVAISAPVVLIDEVLKWAERRLYNNIPARSTVEYQNGVVGKPKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VQG3</accession>
    <name>A0A317VQG3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_605679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000029">
        <property type="protein sequence ID" value="PWY75287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025463914.1">
        <property type="nucleotide sequence ID" value="XM_025616502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VQG3"/>
    <dbReference type="STRING" id="1450535.A0A317VQG3"/>
    <dbReference type="GeneID" id="37118645"/>
    <dbReference type="OrthoDB" id="3799035at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY75287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="109" mass="12280" checksum="F3FD396BCDDCBD26" modified="2018-10-10" version="1">MAVAARDNPANTWIYDTSSSHHLTPDLDSLTEYHKLVSYKYYIYSTSEGTNTTAKSASYITVYLESPTGKPTALKIKAYYQPSLEYGLLSADRLYTDFNLYGTIKDLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VR75</accession>
    <name>A0A317VR75_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_208180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464056.1">
        <property type="nucleotide sequence ID" value="XM_025606134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VR75"/>
    <dbReference type="STRING" id="1450535.A0A317VR75"/>
    <dbReference type="GeneID" id="37108277"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY76059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="563" mass="60998" checksum="DF46728D44047043" modified="2018-10-10" version="1">MNPDARRSACDRCRGQKLRCVRPFQARGLSPCERCLKAGAECTNSLSYAQRKLQEARQSASFLDQRSSRIYESVSVPRAPPDFAESIDSIPAKRKLTQPFLESAHYVSPVTIHPSVIGGRSGETVSRAAPKQPPTSLSATDQNPDLSRSKTLGYGVEPLDFDVRLSPEATGHGSDQFMDMLFDDPKVTTARTRPEHLDEEPPPQETSGTASPPLGTKEDCLHCLSELSSQILRDSSKMRAMPLPDILSFSAWPDNSKGQPEKGLQNSIGRLLELTQAYLNILHCLKLATASAMSHPSSSSPSFHHRSPRSPSNDSDCSYSEYWNDPEHLAVHNQENPPRTGPENLISFPDAMPDPASKQSVGSSGVDMPTTLTILTCYIWLLHAYGTIFHRIHAALSADSSVPFPSLPVPSLSTLASSTTADLSTRPSSFSSSGRFATQLMPSVLPGLHIGGFDLNSHRDLQLEIIVQLSSRMLGRIEELLGISLVSSQSPGRPDVTWNGSDNGANLSGRKDGGGILDNASASALLEVMLKHHNLGYFKDVDGGAGSVKQTLNDIRAILRRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VS11</accession>
    <name>A0A317VS11_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfite efflux pump SSU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BO94DRAFT_559445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Sulphite efflux pump required for the secretion of sulphite as a reducing agent. In the presence of sulphite, cystine in keratin is directly cleaved to cysteine and S-sulphocysteine, and thereby, reduced proteins become accessible to hydrolysis by a variety of secreted endo- and exoproteases. Excretion of sulphite mediated by an efflux pump also represents a detoxification pathway for dermatophytes during infection of the epidermal stratum corneum, hair and nails, which are rich in cysteine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464088.1">
        <property type="nucleotide sequence ID" value="XM_025614069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VS11"/>
    <dbReference type="GeneID" id="37116212"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09299">
        <property type="entry name" value="TDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.150:FF:000004">
        <property type="entry name" value="Malic acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF3">
        <property type="entry name" value="ACID TRANSPORT PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="PWY76091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="403" mass="44421" checksum="44E551A26C3D81FA" modified="2018-10-10" version="1">MPDNEGQETRQPTKPLSIAICSFSSQWFLIPQGTGIIAVILHRLDYQFDGLQVLSRIVWVYTIVLLALCLSIYLARIVMYPRCVARALRTSMVETSCLASISITFTTIIQMIALTVAQDWGAGWPMASYVLWWINTAMAVIAVMGIPYIFINLQSPGIKAIVPSILLPLISSLTSASGGGVVCEYSGVSARLQVPIIIVAYLEIGISIPLAMAFDDVFVARLFEREFLPMNQVYQDMILCGPFGQASFALLALGRVVRSGAFAQYDRGTFLSAEAAIPIGYTSQFAGLLSWGYGTFWWGYAILSILHTVFKQPGGWRKTRYSLSAWSLVFPWGVYTNAAVELGKAMESPAFKVWSTVLLLLLLIICIVNHVLTIKGLITGKICSLQYGWRVGHYQAGEVDKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VS47</accession>
    <name>A0A317VS47_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BO94DRAFT_498574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000026">
        <property type="protein sequence ID" value="PWY77214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464401.1">
        <property type="nucleotide sequence ID" value="XM_025609350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VS47"/>
    <dbReference type="STRING" id="1450535.A0A317VS47"/>
    <dbReference type="GeneID" id="37111493"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="432"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="PWY77214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="513" mass="57216" checksum="3D835F00CC5D16CF" modified="2018-10-10" version="1">MDGDVVAQFAEITGSKPELAAQYLQLADFNIEQAVQLFFENGGAPLTDEPLPSVSTPQQPSNAGGGVVQVDSDDDVTIDETRSAPRNHPSHGATLEDDAAMARRLQEEMYGGGDTEENVRAPMARTTETLVGPEADFDDGDMHASILGQLRARQQRNNRPGIFNQRDTSIWTGDEESSQRERLAAATGGASEASNKSNMLAEMYRPPFDIMSRLPWDLARQEGRDNERWLMVNIQDPSVFDCQVLNRDLWKDPAVKETVKEHFIFMQYSKDDPRAGPYLQYYFQASNVSDNYPHIAIVDPRTGEQMKVWSGPPVIKVSDFLMQLHEFLDRYSLKHNVRNPVAKRKPEKKEKGIDAMTEEEMLEMAMRNSLGDEASQPPKVEDPDDLTRSTEDVKGKGRAVDEDVGMEEAEGPEQSAFSSIPDDRFHTEPPADPATTTRIQFRHPSGRVIRRFALSDPVQRIYEWLKAEPPLADKAGVGFELNAMGRNLIDSLGQTVADAGLKNGTVMIGYLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VUY6</accession>
    <name>A0A317VUY6_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_187013</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464625.1">
        <property type="nucleotide sequence ID" value="XM_025606015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VUY6"/>
    <dbReference type="STRING" id="1450535.A0A317VUY6"/>
    <dbReference type="GeneID" id="37108158"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000431">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY78113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="355" mass="39157" checksum="A97E2ED04DF964C5" modified="2018-10-10" version="1">MASAGPSGGSVTELAARLYDACVNQFPSDHLFYQQDLLGLNLVPKNDLALLLQCTQSLVDQKLFRLLQGKNDRLAWKIISREDAEKLQNLSPDESLVYNVIHSTGRSGIWVRAIGNRTNLHKSILDRCLKSLEGKSYIKSVHNVKYPSRKMYMLANLAPSEDVTGGAWFTDGVLDENFINSVAGFIEYTVSRKSWYEVPSSDGPRNKRIKTADGGMAVKQEGAPKEYLPFPAGYQGYPTVPMLTGAVNESGITPVRLGEESITQLLEMLCYDNKLVALNNGEVYRSVKNPEEVKSQQARKPRGDDAGIDDRLVKNGMTEAPCGHCPVFKLCAPGGAVSPESCEYFDPWLEKALGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVS4</accession>
    <name>A0A317VVS4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Lysophospholipase</fullName>
            <ecNumber evidence="3 11">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_568466</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the release of fatty acids from lysophospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="3 11"/>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464007.1">
        <property type="nucleotide sequence ID" value="XM_025614677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVS4"/>
    <dbReference type="STRING" id="1450535.A0A317VVS4"/>
    <dbReference type="GeneID" id="37116820"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10 11" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7 10 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016192942" description="Lysophospholipase" evidence="11">
        <location>
            <begin position="19"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="12">
        <location>
            <begin position="28"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY76010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="595" mass="65518" checksum="0D1C423AC9854D84" modified="2018-10-10" version="1">MISHIVLPVILAAATALAADSYAPHYVDCPEDIQLVRQPRATSLAESEWVHGRKGQIVDSLGRYLSNLDLEGFNTTEYMARVRANVDYNVPVIGWANSGGGWRASMTGVGGLQAIDERTPGAAEAKVGGLFQMLTYIAGLSGGSWPVSSPVFHNYAPISQMIADWQVDVNRFTDADVESYFEIIAEKAEAGFNVTVADFLGQGFAAQVIPGVNRTWSSIPELPGFKNFSGPMPILIASSINKSSPVEDGIYVPSWEAPWYEWNPFEFGSWATGFVPTKYVGTIPNENNTAEQCVENLDQTSFVLGSVASAWNYWYLSDVTNGTLGTFSKRDSAIEKRDTETDELVEFIDGLVSEYFNSTVSQISNPSIPNAFNPDENITLADGSEAGQSIPFIPLIQPERKLDFIMAWDDDSDSEPYTWNNGTNIWDSYVHAKSHGLPFPEVPPVREMLARNYTLKPVLFGCDTNLTTTRDATSPIIAYFANSPYSWYSNFSWSTDTMSNAEAHGVLQNSFNLVTQGNSTLDSTWVECLGCAAIDRSLARVGMQRSQACEQCFQEHCWDGTLSAGVGEDFMLNPYPALEPGLSYKVWSEEHPDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VVU5</accession>
    <name>A0A317VVU5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="2">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_473758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000028">
        <property type="protein sequence ID" value="PWY76040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464037.1">
        <property type="nucleotide sequence ID" value="XM_025608488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VVU5"/>
    <dbReference type="STRING" id="1450535.A0A317VVU5"/>
    <dbReference type="GeneID" id="37110631"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF76">
        <property type="entry name" value="TERPENE CYCLASE_MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="5">
        <location>
            <begin position="104"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="4">
        <location>
            <begin position="402"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY76040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="744" mass="84762" checksum="19B7175E53CD5D8C" modified="2018-10-10" version="1">MASKYTLKVKNHLGGDQSDVTRPFYTKTTDTEGWHLVVTEDLGRLRWIYVHDKEERKSRSQDATTKFFLDRPRGILDSGAAKTASEAIYKGIQFQTNIQVRGLGCWAADLSCIFFVTPMLIIAWYITGAEIDEAYMIELVRFMFKLQNPEDGGWPTYLHEESSLMGTTLVYIALRLMGVPADDEHLRRGRSYYVRQGGAVYLPGWAKFWLALLGLYDWEGTDPYPVEVWLLPKWLPLSPWKWFVISRQVGLPMSYLSSRRFTLPTNDLLDEIRTELFPEDFSSVNFAAFEGVVNPFKRHQAKGWVMRTLNWTLANVWYPWICPSKLKEKGEQEAWEILQHSERASTSTGIISLEAWLNMIAFYCAEGSGSPGLKRIQEVSLEYLWMSSSGMQSMSIHGGHGWDTSLALQTLVYTGLANHPGFEDNAIQAYEFLIQQQLVEDWNDSPPCHRPSRLGAWSFTTHYHGFPCSDCTGESLKAILMLESETNLRRMSEKNYRLAVDNLLLIQNPSGGYSSFEPIGAGPWLEHLNGTEMFGPVMTEHDYVECTSSCITALALFRARNSQYRSEEIDTAIERGVKFVETSQQADGSWMASWGITFTYGAFFAMEALHCGGRTYENSSVVRAGCRFLLDMQECDGGWGETLESCMSGLYVRAPRSHTVQTAWSCLALMYAGYPDLKPIQRGLDLIRSRQQPTGEWEQEYPVGSGILTCHIQYHNYIYSFPIRALAMYEKRYGEGLFFNDRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYE4</accession>
    <name>A0A317VYE4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C6 transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_568024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464544.1">
        <property type="nucleotide sequence ID" value="XM_025614659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYE4"/>
    <dbReference type="STRING" id="1450535.A0A317VYE4"/>
    <dbReference type="GeneID" id="37116802"/>
    <dbReference type="OrthoDB" id="3037908at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF3">
        <property type="entry name" value="C6 FINGER DOMAIN TRANSCRIPTION FACTOR DBAA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="104"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY78032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="533" mass="61064" checksum="D5ABCE0239CF6C34" modified="2018-10-10" version="1">MVSTPTISRQRPGSACEECRRRKVRCDRRRPQCQVCFETGIECKINTTRLPRGPRKGQLRTLRTRIAALERCLADQHPEINHQMASLFDGSIIDCDSEEDPLRDLPSLPDSLPVMPDTSDDQRSSRSPRSPGSPNRPTGLVSDLMRADLDQLYFDRVHPFAPILQRWRYHVWAKQPKKTEAQTCLQYAMWTVAASLSAQFQSLRDRLYSETRRMLDALDLQGPKTEAPGIEQAQAWVLVCIYEYMQLSPLQAWMSTGRCCRLVLGMRLYELDDPNSPVTMAREQEAVLVDWIGLEEQRRTFWMAYSLDRFISFHNGLPFTLNEQLITTRLPSPEEDFQSGQPILTSYLSELMTLPTNTTTTPSPFPLGRALTHRQTLAVEQLHPQSLDIFWTRHTYLHDLLTHRIQILNTYPHVDPMLMFARIVAQSMVLFLHSVLESIAWKTGDHLLGIIEFERVCVLAAHDVVALVKMQGSLGYFKVHPLTPIPLMMCSEFFSAHGYLDPSFDVMLQDLVECLQDLERVKNPVQSPTLSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYN5</accession>
    <name>A0A317VYN5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BO94DRAFT_166263</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464955.1">
        <property type="nucleotide sequence ID" value="XM_025605906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYN5"/>
    <dbReference type="STRING" id="1450535.A0A317VYN5"/>
    <dbReference type="GeneID" id="37108049"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="PWY79383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="147" mass="16523" checksum="8962974F4FA6D6BA" modified="2018-10-10" version="1">MALKRINKELTDLGRDPPSSCSAGPSGDDLFHWQATIMGPGDSPYSGGVFFLNIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRPRYEATAREWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317VYN9</accession>
    <name>A0A317VYN9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-containing monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_522475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000025">
        <property type="protein sequence ID" value="PWY78038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464550.1">
        <property type="nucleotide sequence ID" value="XM_025610183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317VYN9"/>
    <dbReference type="STRING" id="1450535.A0A317VYN9"/>
    <dbReference type="GeneID" id="37112326"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY78038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="601" mass="66532" checksum="F7BB34098DBDE03E" modified="2018-10-10" version="1">MANLPQGILPTLPCSLPQCHLREDIDAAAIAKEFTTPLSRLSLDHVTPDAIWRDSVALTGTFRTFYSAATITKAWNDRCLARQAQGFQLTPEAARAVRPAPCLGWIEVPFTFEIEAVPAATCSGFLSLVPDGTGGWKIWLLRTILEEFRDQPSVDELEPGSLTAHQSFSDGASYECVVVGCGQSGLSVAGRLQALGVSYLVVDKAPRVGDSWLQRYESMKLHSPKDAAQLPFGPTFTDEYPELMSRHDLARGYQNWAERYSINIAFSTELTSGSWDEDYRKWTLQLRQQQGEQVTTRSITCSHVVMAVGAGGHEPVRPTYPGEDIYQGDILHTAQYKSPRQWEGKHAVIIGSANSAHDAAADMVGTGMASITMVQRSPTCIIPVEYMPKLSKGTMLADRHQLSNPLAVSRLVSLLSIRAQIAQNPERFDALERAGFKVDRDGEVVAHVNERYGGHYMDVGNCANIAKGLVKVKSNSHPTRFTPTGLLFADDTHFPADVVIFATGYKWNVRDTIGELFGKKVYDQVEDYWGLDKEGEIRGAFKPSPHGHIWFISGTTTHSRYYSRFIALHIKADVLGTPVPVYRDTPRDEIPRVVENGEYTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W045</accession>
    <name>A0A317W045_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxysterol-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_537774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000024">
        <property type="protein sequence ID" value="PWY78577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464886.1">
        <property type="nucleotide sequence ID" value="XM_025612349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W045"/>
    <dbReference type="STRING" id="1450535.A0A317W045"/>
    <dbReference type="GeneID" id="37114492"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000020">
        <property type="entry name" value="Oxysterol binding protein (Osh7), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY78577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="416" mass="47325" checksum="72AE153D919E4136" modified="2018-10-10" version="1">MPISVPHIRHRSSLSSNRSHDEPKAEPVSGDDEIVEPDQGNVLSHIISQLRPGADLSRVVLPTFILEPRSMLERITNFMAHPETLLPMPTIDDPLERFVSVVKFYLSGWHIKPPGVKKPLNPILGETFTCYWDYPDGTRGYYISEQTSHHPPKSSYFFMAPEHNIRIDGTLKPRSKFLGNSAASMMEGIAILRFMNRGQDKEKGERYIVTQPNMYARGILFGKMKYELGDHSYVRCPENNLVADIEFKTKGYFSGTYNAIGGTIKNEKTGEVYYELSGLWNGEMHIKDVHTHKKDLLFNATSAKHTPPSSRPIEQQGERESQRLWHNTVKAIIARNHEAATDEKTKIEDRQREEAAKRVEEGVEWHPRLFRRVQGGPNGPDEGEEDLDWIINAQVDPHNAEVAIKQILSIAPILED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1E4</accession>
    <name>A0A317W1E4_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tim44-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_626330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000023">
        <property type="protein sequence ID" value="PWY79421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025464993.1">
        <property type="nucleotide sequence ID" value="XM_025617350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1E4"/>
    <dbReference type="STRING" id="1450535.A0A317W1E4"/>
    <dbReference type="GeneID" id="37119493"/>
    <dbReference type="OrthoDB" id="19619at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051975">
        <property type="entry name" value="mtLSU_mL45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L45, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28554:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY79421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="35866" checksum="49ED0A4A7788C3DC" modified="2018-10-10" version="1">MASSLSKGPVFSAIRSNNTPFATLYSKTLSGPAAAAPCQRRPFSQSSQRNGMRGLPENISIPQPAQPSMRTRGRDMARADLPQDIGLLPGTFIRPLWRDMPSIFHQPSERLHMEWLWVKSAFQNFVALLAYSKWINKGLPLRLKERRQVALDLHKTMYSAFAAGDSATLRKVCCSGLANQLSGRISSRPRGEKVTWNLEKYIKSPATFFTGVRVLADRATQIPELPDSGVRQVVLRITSRQSKGKVSPGDSTEVANNAKQQDCTEYLVIQKLRWVGEEGEWRVWGHATPTTVEDLESPFFARGLSMADRMEAMKESMGAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317W1M0</accession>
    <name>A0A317W1M0_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BO94DRAFT_521286</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000022">
        <property type="protein sequence ID" value="PWY80373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465232.1">
        <property type="nucleotide sequence ID" value="XM_025610141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317W1M0"/>
    <dbReference type="STRING" id="1450535.A0A317W1M0"/>
    <dbReference type="GeneID" id="37112284"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_uS15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="PWY80373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="33961" checksum="0CAC5514EF0BA7C3" modified="2018-10-10" version="1">MPPRISLQPSLRAITGPSSVQLPFAALSLNPTKTSVRAGSTESRERRRHSPFLMAQSRQRKAANISRQKELTKEREGSVGSPLETEPTPFIQELRKTQSTLQDRDINYFVTPDGLKDAMEYSKNLTSPVRRADRDTADPQLEKEAAERHLQEHRNAQEAIRRIISIANGNTQDRMRLHIQKCIETLGRHNTDKVLPPKPSSVSHESATVHPEKTPRVGPDTGSPEVQVAILTAKIINLSRHLQTTKKDKHNKRNLRVLVHKRQKLLRYLRRKERGGPRWQNLMETLGLSDAAWNGEISM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WB71</accession>
    <name>A0A317WB71_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_469696</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465836.1">
        <property type="nucleotide sequence ID" value="XM_025608299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WB71"/>
    <dbReference type="STRING" id="1450535.A0A317WB71"/>
    <dbReference type="GeneID" id="37110442"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.510:FF:000004">
        <property type="entry name" value="Putative RNA export mediator Gle1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="80"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY83051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="486" mass="55329" checksum="7F9F23E3351F035D" modified="2018-10-10" version="1">MGRLSYPSQLDSPSRQLVLDLARDLEQLRVHNTELKKVKAYERRSFYENLDRIDSEREAQHNAALDKAAALHDQVLEEAEETLRAHQRAVEEENRRKEEEARKEAERIEREKAERLRREQEEAARQEKRKRQAEAQKAEQEASQRQAEAAQKAQTERQRQVGGSRLNEAEIKTQARYVELHQHLKQFRQYLKNEAKTNDIVKQNMGDLRRTIKKCVGQLREGTGANQVQLRQIQATLAKAAAIPEPSVDIRQFIAFPPENIAGSDDNKAPALLIYALNIFSKCLISSLITEASINLGHAEPVGIVAAQIFSIDAFIYKGCHLVDILWAKYRVVCPALWGFYGSEKTEGGRRALGWWRDGGSDGPYVSEQTHADRMTALGAGYAALTLRNFGRTKRQNPFPNTMFWYSMHKILSIPAAEIQDTHVTLLSAMLKSSAERIVGFFGHVGLALMRKAIVELPNSLPRQSMSVNQLKLLRDLYKREKNIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBA4</accession>
    <name>A0A317WBA4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_586826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000018">
        <property type="protein sequence ID" value="PWY83776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466244.1">
        <property type="nucleotide sequence ID" value="XM_025615781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBA4"/>
    <dbReference type="GeneID" id="37117924"/>
    <dbReference type="OrthoDB" id="4508069at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="229" mass="25505" checksum="C31E84D0C9AB3EE7" modified="2018-10-10" version="1">MPLHHPSLNAHHFSWRSIFNSKKDRRFSSASTTLYEKVPNTYPPSEQRSTPQASIPEPSPSPTPSPTQTTFIWQDINPPTEADDLLSDNDDDDTLPSYITTTSTTTSTTPTEKDKDLSPELKTMIDTTKQALHSQLTNPSTPPTSLPGYNDVSGAVVVDWDGLPHFLSPQEEEDRKMKLQRAVQERMLGLPRRTEFQWQGDGRSASLPKYPSTDAGAIAEAKARRSSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WBJ0</accession>
    <name>A0A317WBJ0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_469584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466090.1">
        <property type="nucleotide sequence ID" value="XM_025608293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WBJ0"/>
    <dbReference type="STRING" id="1450535.A0A317WBJ0"/>
    <dbReference type="GeneID" id="37110436"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY83305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="156" mass="16903" checksum="1B642541F1ABB1D0" modified="2018-10-10" version="1">MSSESLPIAPAAFTEAIKELPLPVLYAKVSEIRNSIAHLHRSNQELRTFIAESCESETDKRELEGYIVENEGVAVSMTKRIDLLKAEVESRGQQWIELDEKERGEQNGNSAPSPSQAANGTAEDSEATAQRGSPNPASTENSGDAQAGQDEEGVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WDM9</accession>
    <name>A0A317WDM9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">C2H2 finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BO94DRAFT_495384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000019">
        <property type="protein sequence ID" value="PWY83168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025465953.1">
        <property type="nucleotide sequence ID" value="XM_025609261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WDM9"/>
    <dbReference type="STRING" id="1450535.A0A317WDM9"/>
    <dbReference type="GeneID" id="37111404"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056436">
        <property type="entry name" value="Znf-C2H2_ZIC1-5/GLI1-3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23561">
        <property type="entry name" value="zf-C2H2_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="346"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="PWY83168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="385" mass="42108" checksum="CB74B42086E4D15E" modified="2018-10-10" version="1">MTESPGSPLSSIASDDMSDREDLKQGFSPSGSNMPPSKRRRTGVASWDRNTPVSTTFQDDIPPPSPSTSVSSDTSGDIPNSPNTLALIGGSQDDDYSGQGNDQVTICRWDGCDAGDLGNMDGLVKHIHEEHVGSRQKKYSCEWSDCSRKGQTHASGYALRAHMRSHTREKPFYCALPECDRSFTRSDALAKHMRTVHETEALRPSDPVPKHHNIAASAAGTPTATPAGKVRIKLKLSYPSKDDAGDHSESANDDPAGTEEDLLVAPGGLEKEFDTYEMLLEGPQLYRLLLRQIHWAQQEGVELRDAWDKVCIKRKESWMEKEAIFDDLVEAELRLFRAIVGPDGGYGVPNPVPANGKATSHQPEQRQSEAEMDLGQDPESGSVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WHB7</accession>
    <name>A0A317WHB7_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentatricopeptide repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_468017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000017">
        <property type="protein sequence ID" value="PWY84652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025466577.1">
        <property type="nucleotide sequence ID" value="XM_025608231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WHB7"/>
    <dbReference type="STRING" id="1450535.A0A317WHB7"/>
    <dbReference type="GeneID" id="37110374"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936:SF1">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN GUN1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47936">
        <property type="entry name" value="PPR_LONG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY84652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="81062" checksum="615DE4CE748D6D4D" modified="2018-10-10" version="1">MRQKVDSLDIRNDLSIPPTKPSGRGPRDSLKVATKPIGRNAPKKAEAEDTREGLLYKLAHSEVSSRRGADYYIPHRVLEREMNWLKDPRALADRVVEILKSQDPMLAVALIRRAHYMDISTVVAYNRLLEYCLRMKAPKAAFRFWNDMKKRGVSPNSRSYTTMLDGLAQDFPKERVKPVEIALKIYRSLSESSSRVEPNIIHTNAMLKVCWHHRDMDILWQVAGELPENGPLAPDTYTYATILRAISDVTLSNTAAMGEQNLEAILERRAQGIKEGKRIWSDVVYQWKKGRLALDNHLVDAMAHLLVYNSSCDHDIWEVFALYNQTTGLPIFAEEPPKERKRLYSRTRQESSAIKRRHTEEDIPFVDEGERLWENKSEILEQEEAEEENFDGLFDAVVESGDSSTAENSSEKGKSAPSYLPVKNVELSMLLQACMTMTQGAGAGKSYWRYLTQEEHSHSVKPDGPSYYQYLRLLRYSRSSRDAVQLIRDMMEPNGLAEGKAFHIAMSCCSRDRRNPNVFKYANELLDIMRKALVMPDARALKGYFDLVRSLEKNPQFLMTLNGLDSGDNTKQTDLSALGNRLKASLLTTAAENLRWHVSKLESAVDNSVQPNQRMQKRLSQAAEFSPHVVTLGEHALIAMTEMRRLLDSIKKDFARYVSSDDLAEFEKQAVELRKYSKQTVTKTMRKSLIGASPGMRMDFNTETPMLPETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WKD3</accession>
    <name>A0A317WKD3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BO94DRAFT_493317</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467116.1">
        <property type="nucleotide sequence ID" value="XM_025609197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WKD3"/>
    <dbReference type="STRING" id="1450535.A0A317WKD3"/>
    <dbReference type="GeneID" id="37111340"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF14">
        <property type="entry name" value="BETA-GLUCOSIDASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="11">
        <location>
            <begin position="584"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="PWY86525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="664" mass="72512" checksum="38DDCBFB5FC13B0E" modified="2018-10-10" version="1">MAQTWDPDLIQAGFYAVGQEFYAKGYNMINGPTTGPQGRTPWSGRLVETLGQDVYLAGIAFGRATQGLREAGMIPCGKHFLLNEQETNRSEVYWGNNAVTYPRNNTAYSSNADDKTLHEAYLWPFYDGVKAGLGAVMCGMNRVNGSWSCESSDLLNKLLKTELAFPGFVTPDTSGQHTALGSATGGLDSGATSFWHDASLLPALANGSLTQARLDDMAVRNLMPYFHEGLDQKPRVPLSAATDPVDVRSNHRELVRQVGGAAISLLKNTQQTLPLQRPRSIAVFGANARPSPLGPGTTMDDVHNHKTWNGHLVFSGGSGMGSPSYLITPYDALLTRALTDGTQMMWAMEDALASEDYIAVTGTTGTSAAPTFAGYAAAVETCLVFINAWSGEGNDRVELRNAAQDRMILEVADNCNRTVVAVTTVGARLLDTWIDHPNVTAVLYSSLLGEQSGQALVDVLYGAVNPSARLTHTIARHETDYPVPICLTADCDFHEGVYLDYKYFDRYNITPRYEFGYGLSYTSFAYLPNDNSTNIPAITYVNTTALAHRTAQGPLAPGGPTDLWDEVLHVTLQIANGGPQAGAEIAQLYVTFPDEARQPIRQLRGFQKIFLEVGASGSVQFALRRRDLSYWDVRTQMWTVARGEYTFWVGASSRDLRGWVKYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL13</accession>
    <name>A0A317WL13_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_535274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467382.1">
        <property type="nucleotide sequence ID" value="XM_025611745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL13"/>
    <dbReference type="STRING" id="1450535.A0A317WL13"/>
    <dbReference type="GeneID" id="37113888"/>
    <dbReference type="OrthoDB" id="5366531at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY87174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="842" mass="96533" checksum="68C1937BC8B3D825" modified="2018-10-10" version="1">MRPALLRLLKRPSALSVLDSLISMPIGVEQLDVGRAAKCLRCLSKTAKQAKSVPVTELQHTSANEPSLASTKRPFSFRVYEIHSPHKQAAAESGGPANPHGSGTASDSRCLGLQPERLEYESDIGHTDDIGSRLIDDPVHRNDFALWEELLRYRQRHYGDKGTLDIWEGMTARVGGVQLPVHGEVADFFWQSFVDAGLRRDVVLNEVANYALALWNTTGRRWDKLYERVIGGFIDRGMAQQAVKWHRRLQHPHLTHPDDILHIFRPEITIRQQSRVAALMKSGRRATSPTLWAFRSICRMTQGHQIYIPIMSRLMRSGHVDDMLSMHRFLTQQDDHPHSFVDLEPLLESTKEYGPWEFYQELYSYASQRFPGKLNEHEKTNLQSRTETPKKISHDERPIKDGFGARIFATEALDFDTILSGLEMFNVPALGPQSLREMALRARGSQDLLSKLRQLERAGISLGNSVFARLLRKLASENRDIVLSDLLRCDEHPDVFEDAHIQESILISAYRSQDWRTYHMTLAVLNEVSEEAPDLFNIHFRKHLAAGELALALKLVDEMALRKKGLSKESIDLMITYVLIPRRPGVAPTKGQGRSEAVEVTFLFRVLRRVVPLGASVTPDVWVEMIKRLGMMHCWDEVRTCCLWLARHFSPNSGSINEPLEIISPSTTLNSAHDTLVHRHGNSVLETIFNKQMQAALVHWGFRMRVSSKRDDYNPFGVDGERLVPWVRGLILLRELEENGVQLWMRWISQACRHRLAVLFGRPRRSSRHMSRMLRQENPYSAERVLKDINRAWGQPPLFQGRKSRDFYRLVNPPSSRMSQRRTRRTVWREENLRGAAFVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WL94</accession>
    <name>A0A317WL94_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BO94DRAFT_535641</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 115572</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000015">
        <property type="protein sequence ID" value="PWY86481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467072.1">
        <property type="nucleotide sequence ID" value="XM_025611839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WL94"/>
    <dbReference type="STRING" id="1450535.A0A317WL94"/>
    <dbReference type="GeneID" id="37113982"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000127">
        <property type="entry name" value="Aromatic amino acid aminotransferase C56E4.03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="110"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="PWY86481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="591" mass="66272" checksum="2D58B641DAECEDCE" modified="2018-10-10" version="1">MVHSMLSPPLDLSHHFSSVTKRREASETKSLYKYFFIPGIANLAGGLPNASFFPYDTLEATVVHPERFSTTPDNDQTKNPGYSHSTERRIVPKESPTTNLLKKIDLTTALQYGTAEGLPVMADFIRQFTRDHLHPNVPYAGGPSTLLTCGSTDGFAKAIETFSSPWDPRRDWISQREGILCEEFVYMNAIQTVNPRGLNVVAVAIDAQGMLAYGKGGLADVLENWDFKKGRLPHLMYTITIGQNPTGGTLSVERRKEIYALCRQYDIIIIEDDPYWNLQYPSAAAMQAQYRGSTAVDVTPRNYNAHGRSSGYDFLDSLVPSYLSVDTDGRVVRLDTFSKTIAPGCRLGWITAQPAIIERLTRLTETSTQQPSGFVQAMVAELIVGQQVEDGQKNKNKKSEQAWQMTGWVRWLEGLRAGYEQRMQAMCSILEEGKYAINTGSAFDDTHSVADEGAWEVLDKIQMYEFSWPTGGMFVWVRVCIETHPLLQKYGQNKLIQALWVHLMQKPYLCLLGPGTMFAPTSETLERAQGYYRLCFAAMPAEDVPEISQRLVDGFRAFWQRKDLDGLDDDDEVALKKLRAESSANLLGVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WLX1</accession>
    <name>A0A317WLX1_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">xanthine dehydrogenase</fullName>
            <ecNumber evidence="4">1.17.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BO94DRAFT_517257</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 115572</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>hypoxanthine + NAD(+) + H2O = xanthine + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24670"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>xanthine + NAD(+) + H2O = urate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
        <text evidence="20">Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="20">Binds 2 [2Fe-2S] clusters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the xanthine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.4" evidence="4"/>
    <dbReference type="EMBL" id="MSFK01000014">
        <property type="protein sequence ID" value="PWY87339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467547.1">
        <property type="nucleotide sequence ID" value="XM_025609985.1"/>
    </dbReference>
    <dbReference type="STRING" id="1450535.A0A317WLX1"/>
    <dbReference type="GeneID" id="37112128"/>
    <dbReference type="OrthoDB" id="8300278at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004854">
        <property type="term" value="F:xanthine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.120:FF:000016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000015">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000003">
        <property type="entry name" value="Aldehyde oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000002">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.365.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000001">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000004">
        <property type="entry name" value="Xanthine dehydrogenase/oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.120">
        <property type="entry name" value="[2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.50">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.365.10">
        <property type="entry name" value="Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046867">
        <property type="entry name" value="AldOxase/xan_DH_MoCoBD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45444:SF3">
        <property type="entry name" value="XANTHINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="MoCoBD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20256">
        <property type="entry name" value="MoCoBD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000127">
        <property type="entry name" value="Xanthine_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="CO dehydrogenase flavoprotein C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="CO dehydrogenase ISP C-domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="CO dehydrogenase molybdoprotein N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="Molybdenum cofactor-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 20" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 20" id="KW-0408">Iron</keyword>
    <keyword evidence="12 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 20" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="21">
        <location>
            <begin position="30"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="22">
        <location>
            <begin position="261"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="1290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="379"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="793"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="828"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="906"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="938"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="940"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="1036"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="1105"/>
        </location>
        <ligand>
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </ligand>
        <ligandPart>
            <name>Mo</name>
            <dbReference type="ChEBI" id="CHEBI:28685"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR000127-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="PWY87339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="1358" mass="148456" checksum="4D72B2A2A1AD9339" modified="2018-10-10" version="1">MAPGILESPKPTVAASKVVTLAQLTEDWDDTIRFYLNGTKVVLDSINPEVTLLEYLRGIGLTGTKLGCAEGGCGACTVVVSHLNPTTKKIYHASVNACLAPLISVDGKHVITVEGIGDVKNPHAIQQRLAIGNGSQCGFCTPGIVMSLYALIRNNPQPSEHDVEEAFDGNLCRCTGYRPILDAAQSFMAPKGCGKALANGGTGCCMDKQDGSGGCCKQPSADTADGDGPKFTPPDFISYNPGTELIFPPHLHKHEYRPLVLGNKKKKWYRPVTIEQLLEIKAVHPDAKIIGGSTETQIEVKFKAMKYSASVYVGDIPELRQYSLKDNHLEIGANVSLTDLVSICDEALDRYGSLRGQPFSAIKKQLRYFAGRQIRNVASPAGNLATASPISDLNPVFVATNTVLVAMSLGEVIEIPMNQFFKGYRSTALPANAIISGLRIPVASEKGEYLRAYKQSKRKDDDIAIVNAALRVSLSPSHDVLSVNLVFGGLAPITVSARNAEAFLVGKKFTNPATLEGTMSALGQDFDLKFSVPGGMATYRKSLALGFFYRFYHDVLSGIQVREADVDEDVIAEIERAISSGEKDHEASAAYQQKILGKASPHVSALKQATGEAQYTDDMPVQKNELYGCLVLSTKAHARLLNVDPTAALDIPGVFDYVDHTDLPNPQANWWGAPKCDEVFFAVDEITTAGQPIGMILATSAKIAEEGARAVKVEYEELPAILSIEEAIEAGSFFEHSRYIKCGDPESAFKEADYVFTGESKMGGQEHFYLETQACVAIPKLEDGEMEIWSGTQNPTETQTYVAQVVGVAANKIVSRVKRLGGGFGGKESRSVQLAGICATAATKAKRAVRCMLNRDEDIATSGQRHPFFCRWKVGVTKEGKLLALDADVYSNGGHTQDLSGAVVERALSHIDGVYRIPNVHVRGRICKTNTVSNTAFRGFGGPQGLFFAECIVSEVADHLNIPVEQFRWQNMYQPDEKTHYNQALKDWHVPLMYKQVMEESSYEERRKSVEEYNKKHKWSKRGMAIIPTKFGISFTALFLNQAGALVHIYHDGSILVAHGGVEMGQGLHTKMTMIAAEALGVPQSSVFISETATNTVANTSATAASASSDLNGYAIFNACEQLNERLRPYKEKMPGATMKELAHAAYFDRVNLSAQGFYRTPDIGYVWGENKGQMFFYFTQGVTAAEVQIDTLTGDWTPLRADIKMDVGRTINPAIDYGQIEGAFIQGQGLFTTEESLWHRASGQIFTKGPGNYKIPGFRDIPQIFNVSLLKDVEWENLRTIQRSRGVGEPPLFMGSAVFFAIRDALKAARRQWNVEEVLRLESPATPERIRVSCADPIIERARVVPREGEKSFFVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WND3</accession>
    <name>A0A317WND3_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_465439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467646.1">
        <property type="nucleotide sequence ID" value="XM_025608115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WND3"/>
    <dbReference type="GeneID" id="37110258"/>
    <dbReference type="OrthoDB" id="4412445at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34673">
        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34673:SF1">
        <property type="entry name" value="COLD-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="79" mass="8345" checksum="2EDE720ABAD5EEA2" modified="2018-10-10" version="1">MCDIPFLPIFPICFQCGTDQNPCRCKVVGPTLGFVCTVVAAVICYPASIFCGCCLTQTGKDVLGYPVKVNGIVSNAIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WQY0</accession>
    <name>A0A317WQY0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_545919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000012">
        <property type="protein sequence ID" value="PWY88843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468205.1">
        <property type="nucleotide sequence ID" value="XM_025613269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WQY0"/>
    <dbReference type="GeneID" id="37115412"/>
    <dbReference type="OrthoDB" id="4343031at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY88843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="119" mass="13790" checksum="E435BE9592B86FD9" modified="2018-10-10" version="1">MSAAMILRRSSTLSRPPLLRPAYAARVCYYHPPEVHSNKDEEFFITASFPDDFEAPSLVKKRDPQGQSLGHWDEFHATSSEVSVKADRGDIHIHQQQQQWSRDLDRRLQEAEEPKIDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WS72</accession>
    <name>A0A317WS72_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sucrase/ferredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BO94DRAFT_534984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467760.1">
        <property type="nucleotide sequence ID" value="XM_025611667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WS72"/>
    <dbReference type="STRING" id="1450535.A0A317WS72"/>
    <dbReference type="GeneID" id="37113810"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF8">
        <property type="entry name" value="SUCRASE_FERREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="PWY87977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="289" mass="32688" checksum="7C80E2BDD5A7FE9C" modified="2018-10-10" version="1">MFRSLLSRGGLIRNDSYIFPTVDPNEDGPDCKMDCADCTVQFPSKVKVETSRPLYGHIKEFHTHVLVATGKSDWTERVENEKGSLMEAFDESNKSKHGRIMVSASNLESPETDEKTDGTTILLLPSFTFIDSVQRSDANEVITRFIDAPLSQNGIPPNPESKLFPRPCQYDYVVLLCSHRRRDARCGITAPLIKKELERHLRPLGLYRDANDERPGGVGIFFVSHVGGHKFSANVLIYRKEQEQMIWLARIKPEHCEGVVKYTLLQGKVVHPESQLRGGFDRSRGVTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTG8</accession>
    <name>A0A317WTG8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nagb/rpia/CoA transferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BO94DRAFT_534404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468540.1">
        <property type="nucleotide sequence ID" value="XM_025611541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTG8"/>
    <dbReference type="STRING" id="1450535.A0A317WTG8"/>
    <dbReference type="GeneID" id="37113684"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G14290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="PWY89629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="531" mass="60093" checksum="3AC1653A3255AC4D" modified="2018-10-10" version="1">MSTQEQPHQSHLEKRSVVSSFIFNFPKGPCEKPVVALFKRSEKVRTYSHHLAPISGSVSRSDSSELEAAWRELSEETSLDNSSLTLWRTGKPFTFEDPSVNREWTVHPFAFKLKDPSEGGSGESAIKIDWEHEGWGWYDPYSVLKDEKLETVPRLQDSLRRVWFEGDLSERAGKALSLGLERIRNDHESGAQELTAIALMAFRDFIIFTENGINSKEWWNTARMAAWHIIKNGRESMGAATMNALLSVLDEMEDILKDEETSSEHKWERVLSMLDHHLTSRKSRAMQVKDAFANYLRFRFLHHGETLDKLTILTVSASSTIRDSILDAYASLDIRKLELRILESRPLFEGTSIGSSLLSNYKSRFIDTPGKDLKVKIYTDASAALAAADVDLLLLGADRISPTKGVSNKTGSLPAVLCTKHVSPNAQIAVLSDLEKINCASSMIDDDRYEDNDPMEVISAWRNDGVNAARVLEDSMKEDTSTVEVKNTYFEWVPLYFVDAFVSEEGVMDESRIREKSKELGETMKRFFDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WTP8</accession>
    <name>A0A317WTP8_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_623660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468610.1">
        <property type="nucleotide sequence ID" value="XM_025617165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WTP8"/>
    <dbReference type="STRING" id="1450535.A0A317WTP8"/>
    <dbReference type="GeneID" id="37119308"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="97"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY89699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="356" mass="40037" checksum="1F28CFB9289D85AC" modified="2018-10-10" version="1">MAPIRFRHDPSWSYQQGMSGSMLKAFLRTFTALHMKWPLSLKPHHESERFVLINPTHPEYYTGVMEDPVIQPETIGATWYPEPYSPDLPLPEGQHVILHLHGGSYILGDGRTSSCNFLARTLLEHTPSSFMLCPQYRLACNQNGRFPAQLQDALAAYVYLIHTLKIPPSRIVLSGDSSGGHLVLALLRYIVEYNRPERLPAPKCSWAWSPWCDVPAAVDPSAWTHSTNYKTEYIPGSFPAWGARQFLGDAAITDQVKPYVAPIWHPFVVPSPVLIMTGGREVLCQDHEKLAQEFQKLEGNQSKVELFMEEKVPHDVLMIGWIMGFKDEARHCAIGAGEFLQRMDATPRASGMDATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUC9</accession>
    <name>A0A317WUC9_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative TATA-box-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_56084</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467633.1">
        <property type="nucleotide sequence ID" value="XM_025614182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUC9"/>
    <dbReference type="STRING" id="1450535.A0A317WUC9"/>
    <dbReference type="GeneID" id="37116325"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY87850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="262" mass="28259" checksum="33BF251C7076524A" modified="2018-10-10" version="1">MDSLTTHPSTAQQARAFTSPASLSFPGGAGDLTPPSDKDGNMAMAQGMNGMVNGQQQGANAANGNGVAPATPAATPSANTPGSGIVPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIREPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASRHHNFSSYEPELFPGLIYRMMKPKIVLLIFVSGKIVLTGAKVREEIYQAFELIYPVLSDFRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUH5</accession>
    <name>A0A317WUH5_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BO94DRAFT_516187</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 115572</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467683.1">
        <property type="nucleotide sequence ID" value="XM_025609951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUH5"/>
    <dbReference type="STRING" id="1450535.A0A317WUH5"/>
    <dbReference type="GeneID" id="37112094"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="PWY87900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="393" mass="44865" checksum="9224E478A3125814" modified="2018-10-10" version="1">MSAATDKARFFLEKSVPELREFERKKIFTKEEITSIIKKRSDFEHKLNARGALPIDFVRYAQYEMNLDILRRKRVKRLGIRSAGYTGQRRIFFVLDRATRKFHGDIGLWIQYLEYAKQQKAYKKVSSILTDALRLHPANVDLWLYAAQYSVDEHADMTQSRGYMQRGLRFCKSSKKLWLHYAKLELIYIAKLVARQRILGLDKPIEAPKPAQEDDLDADMVALPKITGEDINPDAGEDGGVDEVALENLASTPALTGAIPLAIFDTAMKNFENDDSFGHEFYDMVVDFDDLPCLRQILQHVVDTMRNSKPNSPHTQICYIKFPTAGIQVTSSDFPRAFGASFARLKEHRNNPKVAKEIVNWLQPLEKTEGPDASLQKAIVATLRNAERVVQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WUJ3</accession>
    <name>A0A317WUJ3_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BO94DRAFT_465518</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="MSFK01000013">
        <property type="protein sequence ID" value="PWY87920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025467703.1">
        <property type="nucleotide sequence ID" value="XM_025608120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WUJ3"/>
    <dbReference type="STRING" id="1450535.A0A317WUJ3"/>
    <dbReference type="GeneID" id="37110263"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="171"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="PWY87920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="532" mass="59567" checksum="52EF6DDF68F0BFF5" modified="2018-10-10" version="1">MQTWRRTFATSVARLNHRPAARPAGSTLLRCAQLLESQKGSSWEDQEIKLNGFIRSVRKQKRFAFAEISDGSTVKPLQAILNPSQAADLSTGTAVEISGLWKACPPGKEQTHELQTTAVNIVGKTDPETYPIQKKYHSPEFLRQIPHLRVRTPFNSLLSRFRSECLYQLGNVFRHAPNGGFIQVHPPLITSSDCEGAGETFTVMPREAVGTTPADGEHFFRAPKYLTVSSQLHLEAYAAELGNVWTMSPMFRAEKSDTPRHLSEFYMLEAEANFMDNLDSLTDLVEYLLRDLTRRLYDTPVGQEILDAKRPGESSPEESAAPADLRQRWQDMIDGPKWRRMTYTEAIELLQDAVTKDSASFEYPPTWTGGLQLEHEKYIVDVLNNGHPVFVTDYPKPIKPFYMIPSHASGATTQGETVACFDLLLPEVSEVAGGSLREHRLPEIIQNMREHGLIKRASGDEGTATDEGSLYPHLLPGEDLGHLQWYADLRRWGTAPHGGFGLGFDRFLGYLAGVSSVRDVVAFPRYFGRADC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WVA2</accession>
    <name>A0A317WVA2_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF1760-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_489633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468667.1">
        <property type="nucleotide sequence ID" value="XM_025609094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WVA2"/>
    <dbReference type="STRING" id="1450535.A0A317WVA2"/>
    <dbReference type="GeneID" id="37111237"/>
    <dbReference type="OrthoDB" id="5396786at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013877">
        <property type="entry name" value="YAP-bd/ALF4/Glomulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040347">
        <property type="entry name" value="YBP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28020:SF1">
        <property type="entry name" value="YAP1-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08568">
        <property type="entry name" value="Kinetochor_Ybp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="681" mass="75025" checksum="C8E9D761DFCDF98D" modified="2018-10-10" version="1">MAQEEDPLIQALPPATDYLTYLTLLEYQLTPARLPTLHKLLQDEVLTTNIGWDLVQLLLPMLPQSIDCLHDIARLGNPREVILRVSDALMQLQPVDEDEDEDSEDDSAEPAGPGSSGQSGEASQNATGSGDSPSALPRHVVQFNTLVAMLSVLHSRIQTKSPSRFLATSLQAVLEAYTLMPTSETTIALLEFFRTVSPSKRPAPPPRVPSESSVLRLAEAAAPDPEAEVQSPSPASDQEPVLVQKFLQFGLIEVLKSYLLSFSGPSDPGMSWAIRLQEKLQPGMRLIKQETQSDLFATHKELKERDMIIAKITALSRDFGLNDKKLLEIVLQSPGDQPLPLDFEEPPRKADEIPLERHGSLLLLAARAATAELFSSGQVTPIAIYPNLTRIFQNFVGGYNSPDDVAFGQPQVLLDSLLTLTVFSMQQTNDPIPSEKEFIKFVLTLTACTARQNYSSVRRIPGTIIQKHPSQVSQFKLIRTVLEDDRFQSVKDSAIGWLKTGILEAANSSERGTPSEPSIFLNPHYLSVLFPSLFNSSELLMNVSSDLVASWIKFSQTLSPSIHAALSLYYTLVSSSNLRKQLQLEKTYVYFRNRFLEPLKSLCHAFEADLVRNGGDGKIEGAVGESLSQVGMARSVGLVSYMLEQVEDAVGEAFVLQDSELPEPSADDIARVDMIRMETSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WW78</accession>
    <name>A0A317WW78_9EURO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobic surface binding protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_31250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000010">
        <property type="protein sequence ID" value="PWY90593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468971.1">
        <property type="nucleotide sequence ID" value="XM_025606838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WW78"/>
    <dbReference type="STRING" id="1450535.A0A317WW78"/>
    <dbReference type="GeneID" id="37108981"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF6">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016256864" description="Hydrophobic surface binding protein A" evidence="1">
        <location>
            <begin position="21"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY90593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="20735" checksum="CED733284811E106" modified="2018-10-10" version="1">MRPNLPSFLLTLGTITTALATPTPTTHSVKITIRDSSIFTEGLAAVSAKVDILDANILTYPGGDISNITAGAAGLITTLLAETKEIQSYFLNTTEATAVIPPLEELTVQFATAVNNYISIHDLIKVADEGWYIYSQLQEEHTAALTYTGSVVARIPAGNLKDAANALATNITDTLQTGVVAYKDIAVRPTPYPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZ58</accession>
    <name>A0A317WZ58_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_38554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000011">
        <property type="protein sequence ID" value="PWY89510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025468421.1">
        <property type="nucleotide sequence ID" value="XM_025607289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZ58"/>
    <dbReference type="GeneID" id="37109432"/>
    <dbReference type="OrthoDB" id="5333304at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY89510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="829" mass="93384" checksum="FECF72BF59C3DEFD" modified="2018-10-10" version="1">MATAQIPPAPGSSITTRLPASEEVQEYEKILRISDDIFSGTHPRLKVPQQFVRKPASRFPPAPTPAQVKPGDQLKSPPETQPPPSAPSATRPASSQAPSAGGAPSGTTGPSRILPKPASEIDPIFLTKSDDLVRAELQLQRQRVERVLREQLEQKRQESRQKAALQDAKPDFDVSDVLVKAFEMVNPSPSIDAPGAGEPNDSFDENSFYSSRAPDSPQHGEQQRQSPAPQSNSEELATEAPAENYSDELQRLEALNRTGSDQDVQDTYPVADHLVPYDQRHPHHGEVDVAARKYPEPTQPTDAFEEPEYSPPAPGVAPMERDDNHGAQRGYPGGTKRRAPERPRHARRSLSPGSDVRIVRNHITSPAAPQPSRVSPLAIAKVPSVSRPDYGPDRHASPEAPVQPMTSRKRRRLDERVRTRPSYTRAQAPHNVEESFIKEEPVSPPPFTDTLQAYRSRQPQERPVYIDIASPRYTPVLERREAPVRDPAYEYEVYDPHGEPGIPRTVSRLSARRPIRDDQDLRRVASLHQARQPEFAREYVDQASPQSIRAGSYAIVERQPERIRYYDELTAPPARRYIPAGGSPTSPRLHETYYEEEPATRVMAPPPRRIVVDEHGNQYYETLPAPRLQAMPPPSSRLPRSDVHDDRAPLRHASVRAASVLEDPYGGRRYVQDMPPPQAAYRRVTDYARPAPSERRPYGAALDEREPFPRSASVQVTEYGTRRPPYLEEAELPRERIVRMPSVRPPTSRYEDPQVIQRVESVRPGGRDVSVYMDDGTRQPREYIERPVYVATRPLREERYYDGSNPERVILEEGRDVVHRVPQRYGGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZD1</accession>
    <name>A0A317WZD1_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative SAM-dependent O-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BO94DRAFT_488879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 115572</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469069.1">
        <property type="nucleotide sequence ID" value="XM_025609077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZD1"/>
    <dbReference type="STRING" id="1450535.A0A317WZD1"/>
    <dbReference type="GeneID" id="37111220"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="PWY91341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="235" mass="26480" checksum="6273BD7172A34B42" modified="2018-10-10" version="1">MLSSILPFSPDLADRASQYCESHSDIPPDTLLAHWVQTTQKFGDADKMSSKLQGQWMIWLAEDRKPKRVLEIGTYSGFSALAWYLGTQKTKAEIVTLEINSEMIKAAKAAFERFKATDRIRLVEGPAGESIENLTGEFDLIFVDANKDGYEDYVKQILDKRLLSKDGVILADNVFARGLTLGQEFAPHLSNAVRPYWTANGVALDHFTKFLLEDERVSTVLLPLFDGVSFVKWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZK4</accession>
    <name>A0A317WZK4_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_617134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000008">
        <property type="protein sequence ID" value="PWY91773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469501.1">
        <property type="nucleotide sequence ID" value="XM_025616820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZK4"/>
    <dbReference type="STRING" id="1450535.A0A317WZK4"/>
    <dbReference type="GeneID" id="37118963"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000246702"/>
        </source>
    </evidence>
    <sequence length="104" mass="12054" checksum="4FAA14127E823006" modified="2018-10-10" version="1">MTLILPAVAMGVDPFSTPAACLFLVEFTWTIMYETIYAYQDVQHDMTSRLKSSPWLCGTDLPLRPLPRCWACLWSGSWSPWGCWLTCLGFTTLWVVVGLRFRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-10-10" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A317WZM0</accession>
    <name>A0A317WZM0_9EURO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNase I-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BO94DRAFT_555304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Aspergillus sclerotioniger CBS 115572</name>
        <dbReference type="NCBI Taxonomy" id="1450535"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Eurotiomycetes</taxon>
            <taxon>Eurotiomycetidae</taxon>
            <taxon>Eurotiales</taxon>
            <taxon>Aspergillaceae</taxon>
            <taxon>Aspergillus</taxon>
            <taxon>Aspergillus subgen. Circumdati</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2016-12" db="EMBL/GenBank/DDBJ databases">
            <title>The genomes of Aspergillus section Nigri reveals drivers in fungal speciation.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Vesth T.C."/>
                <person name="Nybo J."/>
                <person name="Theobald S."/>
                <person name="Brandl J."/>
                <person name="Frisvad J.C."/>
                <person name="Nielsen K.F."/>
                <person name="Lyhne E.K."/>
                <person name="Kogle M.E."/>
                <person name="Kuo A."/>
                <person name="Riley R."/>
                <person name="Clum A."/>
                <person name="Nolan M."/>
                <person name="Lipzen A."/>
                <person name="Salamov A."/>
                <person name="Henrissat B."/>
                <person name="Wiebenga A."/>
                <person name="De Vries R.P."/>
                <person name="Grigoriev I.V."/>
                <person name="Mortensen U.H."/>
                <person name="Andersen M.R."/>
                <person name="Baker S.E."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 115572</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="MSFK01000009">
        <property type="protein sequence ID" value="PWY91475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_025469203.1">
        <property type="nucleotide sequence ID" value="XM_025613783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A317WZM0"/>
    <dbReference type="STRING" id="1450535.A0A317WZM0"/>
    <dbReference type="GeneID" id="37115926"/>
    <dbReference type="OrthoDB" id="62798at2759"/>
    <dbReference type="Proteomes" id="UP000246702">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF286">
        <property type="entry name" value="5-PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="PWY91475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <db
[file cut: first 33554432 bytes kept]
[document cut: first 30763775 of 33522876 characters kept]
